US Pat. No. 10,188,584

MEDICINAL XIDING VIAL AND DISPENSING APPARATUS AND INJECTION APPARATUS THEREOF

1. An assembly of a reversely pressed medicinal vial and a reversely pressed injection apparatus, comprising the reversely pressed medicinal vial and the reversely pressed injection apparatus,wherein the reversely pressed medicinal vial includes a vial body whose inner wall is a straight cylinder, a first piston is disposed on a position close to a vial opening of the vial body, a blind hole is disposed at a center of an outer bottom surface of the first piston, and the vial opening is provided with an outer edge protruding radially outwardly from the vial opening and a seal cap is fixed on the outer edge to prevent the first piston from falling off;
wherein the reversely pressed injection apparatus includes an injection tube, a fixed push rod and an inner needle which longitudinally penetrates the fixed push rod are provided at a bottom center of the injection tube inside the injection tube, a needle head of the inner needle sticks out of the fixed push rod, an outer needle is provided at an outlet port of the injection tube, a tail part of the outer needle is communicated with a tail part of the inner needle, an inner wall of the injection tube is clearance-fitting with the outer edge of the vial opening, and a free end of the fixed push rod is fitted and connected with the blind hole at the center of the outer bottom surface of the first piston,
wherein an annular sealing gasket that is integrated therewith is disposed at the outer bottom surface of the first piston and positioned between the vial opening and the seal cap; and
wherein the free end of the fixed push rod is sleeved with an annular blade, and when the reversely pressed medicinal vial is assembled with the reversely pressed injection apparatus, the annular blade cuts and separates the first piston from the annular sealing gasket, the inner needle impales into the first piston, the first piston is pushed into the vial body in a direction away from the vial opening by the fixed push rod, and the annular sealing gasket is disposed at the vial opening.

US Pat. No. 10,188,582

OUT OF PHASE CHEST COMPRESSION AND VENTILATION

ZOLL Medical Corporation,...

1. A system for providing emergency care to a patient, the system comprising:a backboard arranged to support the patient;
a chest compressor attached to the backboard and positioned to engage the patient at the chest, the chest compressor configured to provide multiple chest compression cycles to the patient, wherein the multiple chest compression cycles are configured to provide a compression of the sternum to a compressed sternal position followed by a hold of the sternum in the compressed sternal position followed by a release of the sternum from the compressed sternal position;
a cuirass attached to the backboard and positioned to engage the patient at the abdomen, the cuirass configured to generate negative pressure to pull outward on the abdomen and to provide multiple abdominal compression cycles to the patient wherein the multiple abdominal compression cycles are configured to provide a compression of the abdomen to a compressed abdominal position followed by a hold of the abdomen in the compressed abdominal position followed by a release of the abdomen from the compressed abdominal position; and
a defibrillator comprising one or more processors configured to:
control the chest compressor to perform the multiple chest compression cycles and the cuirass to perform the multiple abdominal compression cycles according to a programmed sequence such that the compression of the sternum to the compressed sternal position occurs during the hold of the abdomen in the compressed abdominal position and after the compression of the abdomen to the compressed abdominal position and such that the release of the sternum from the compressed sternal position occurs over a pre-determined time interval, and
control the cuirass to generate the negative pressure to pull outward on the abdomen prior to the compression of the abdomen to the compressed abdominal position.

US Pat. No. 10,188,581

METHOD AND SYSTEM TO EVACUATE ONE OR MORE DRESSINGS USING TWO OR MORE VACUUM PUMPS

KCI Licensing, Inc., San...

12. A negative-pressure source, comprising:a first pump;
a second pump;
a first valve having an inlet fluidly coupled to an outlet of the first pump;
a second valve having an inlet fluidly coupled to an outlet of the second pump;
a cross-over valve having a first port fluidly coupled the outlet of the first pump and the inlet of the first valve, and a second port fluidly coupled to the outlet of the second pump and the inlet of the second valve; and
a controller communicatively coupled to the first pump, the second pump, the first valve, the second valve, and the cross-over valve for operation of the first pump, the second pump, the first valve, the second valve, and the cross-over valve.

US Pat. No. 10,188,579

METHOD FOR CONTROLLING A WALKING ASSISTANT APPARATUS

National Chiao Tung Unive...

1. A method for controlling a walking assistant apparatus, the walking assistant apparatus including a processor, a motion unit, a support unit that is disposed on the motion unit and that includes a handle component operable by a user, a first scanning device disposed on the support unit, and a torque sensor disposed on the handle component, the method comprising the steps of:a) scanning, by the first scanning device, the user so as to generate scanning information associated with gait of the user;
b) detecting, by the torque sensor, a detected torque applied thereto about a vertical axis;
c) estimating, by the processor, a moving speed of the user based on the scanning information;
d) calculating, by the processor, a compliant motion speed based at least on the moving speed of the user, and a compliant rotational speed based on the detected torque detected in step b); and
e) controlling, by the processor, the motion unit to move at the compliant motion speed and to turn at the compliant rotational speed so as to bring the walking assistant apparatus to move at the compliant motion speed and to turn at the compliant rotational speed;
wherein step a) includes scanning the user so as to generate the scanning information that includes a first entry of distance information scanned at a first time instance and a second entry of distance information scanned at a second time instance after the first time instance;
wherein step c) includes the sub-steps of
calculating a first distance between the first scanning device and the user at the first time instance based on the first entry of distance information,
calculating a second distance between the first scanning device and the user at the second time instance based on the second entry of distance information, and
calculating the moving speed of the user based on the first distance, the second distance and a difference between the first time instance and the second time instance; and
step d) includes calculating the compliant motion speed based on the detected torque and the second distance.

US Pat. No. 10,188,565

TRANSPORT CHAIRS

The UAB Research Foundati...

1. A wheelchair comprising:a seat assembly comprising a seat having a front edge and a rear edge;
a footrest assembly comprising an upright member having an upper end and a lower end, and a foot plate extending from said upright member near the lower end thereof;
said seat assembly and said footrest assembly pivotally coupled to one another near said front edge and said upper end, defining a single pivot axis therebetween,
said seat assembly and footrest configured to maintain a uniform spatial relationship while pivoting rotationally about said single pivot axis from a first seated position in which said footplate is elevated above a floor to a second seated position at which said foot plate contacts the floor, whereupon said seat assembly is configured to decouple from said footrest assembly and continue pivoting to an inclined position.

US Pat. No. 10,188,560

ABSORBENT ARTICLE HAVING FINGER TABS AND METHODS OF MANUFACTURING SAME

KIMBERLY-CLARK WORLDWIDE,...

1. A method of manufacturing an absorbent article, the method comprising:feeding a first web of material in a machine direction;
feeding a second web of material in the machine direction, the second web being spaced from the first web by a gap;
attaching an absorbent assembly to the first web and the second web such that the absorbent assembly spans the gap between the first and second webs;
forming a partial cut line through the second web, wherein the second web includes opposing side edges extending in the machine direction, the partial cut line spaced from the side edges of the second web;
folding the first web into face-to-face relationship with the second web after forming the partial cut line; and
cutting the first and second webs after folding the first web into face-to-face relationship with the second web to separate the absorbent article from the first and second webs, the partial cut line defining at least one finger tab on the absorbent article.

US Pat. No. 10,188,559

DISPOSABLE DIAPER WITH BUTTOCKS PART STRETCHING UNIT

UNICHARM CORPORATION, Eh...

1. A disposable diaper, comprising:a front waistline region;
a back waistline region; and
a crotch region positioned between the front waistline region and the back waistline region;
a product longitudinal direction oriented from the front waistline region to the back waistline region;
a product widthwise direction orthogonal to the product longitudinal direction:
an absorber running across the crotch region and extending to at least one of the front waistline region and the back waistline region;
a pair of side flaps extending across the front waistline region, the crotch region, and the back waistline region, said pair of side flaps being disposed on opposite sides of the absorber in the product widthwise direction; and
a pair of fastening tapes each extending, in the product widthwise direction, in the back waistline region outward of the pair of side flaps, respectively, said pair of fastening tapes being releasably attachable to the front waistline region;
wherein
each side flap of the pair of side flaps has:
a lateral edge including an leg opening unit concave toward a center of the absorber in the product widthwise direction, said leg opening unit having a center in the product longitudinal direction;
a leg stretching unit disposed inward of the leg opening unit in the product widthwise direction and stretchable in the product longitudinal direction; and
a buttocks part stretching unit running across the crotch region and the back waistline region, and stretchable in the product longitudinal direction;
the leg opening unit in said each side flap has:
a backside leg opening unit positioned backward of the center of the leg opening unit in the product longitudinal direction; and
a foreside leg opening unit positioned forward of the center of the leg opening unit in the product longitudinal direction,
wherein an area between the backside leg opening unit and a straight line, which passes through the center of the absorber in the product widthwise direction and which is parallel to the product longitudinal direction, is larger than an area between the foreside leg opening unit and the straight line, and
in said each side flap,
said buttocks part stretching unit is disposed outward of the leg stretching unit in the product widthwise direction,
a front end of the buttocks part stretching unit is positioned backward of the center of the leg opening unit in the product longitudinal direction and reaches the lateral edge of the side flap, and
a plurality of convex units convex away from the absorber in the product widthwise direction is formed only in the backside leg opening unit and outward of the front end of the buttocks part stretching unit in the product widthwise direction.

US Pat. No. 10,188,558

MALE URINARY INCONTINENCE DEVICE

1. A method of treating urinary incontinence in a human male having a penis having a penis head, the method comprising the steps of:a) providing a wrap configured to absorb urine and having:
i) a distal region configured to absorb urine and comprised of a plurality of layers, the distal region further comprising a front surface, a rear surface opposite the front surface, a distal region left side, a distal region right side, a distal region length extending from the distal region left side to the distal region right side, a distal region proximal end, a distal region distal end, a distal region width extending from the distal region proximal end to the distal region distal end and generally perpendicular to the distal region length;
ii) a lengthwise foldline located at the proximal end of the distal region and extending generally parallel to the distal region length;
iii) a proximal region configured to absorb urine and comprised of a plurality of layers, the proximal region further comprising a proximal region distal end extending from the distal region at the lengthwise foldline, the proximal region further comprising a proximal region proximal end, a proximal region width extending from the proximal region proximal end to the proximal region distal end, a proximal region left side, a proximal region right side, a length extending from the proximal region left side to the proximal region right side;
iv) a left widthwise foldline extending through the proximal and distal regions generally along the proximal and distal region widths; and
v) a right widthwise foldline located to the right of the left widthwise foldline and extending through the proximal and distal regions generally along the proximal and distal region widths,
wherein the front surface of the proximal region left side comprises a left side fastener configured to removably attach to the distal region rear surface, and wherein the front surface of the proximal region right side comprises a right side fastener configured to removably attach to the proximal region rear surface;
b) placing the head of the penis of the male on the proximal region front surface;
c) before or after step b), folding the distal region along the lengthwise foldline so that the distal region front surface faces the proximal region front surface; and
d) folding the left side of the proximal region and the left side of the distal region together along the left widthwise foldline toward the head of the user's penis, attaching the left side fastener to the distal region rear surface, and then folding the right side of the proximal region and the right side of the distal region together along the right widthwise foldline toward the head of the penis, and attaching the right side fastener to the proximal region rear surface,wherein after step d), the right sides of the proximal region and distal region are located in front of the left sides of the proximal region and the distal region and further wherein after steps b) and c), the head of the penis is located between the front surface of the proximal region and the front surface of the distal region.

US Pat. No. 10,188,557

APPARATUS AND PROCESS FOR TRANSFERRING SUBSTRATE MATERIAL AND PARTICULATE MATERIAL

1. An apparatus for making a structure that comprises a combination of a particulate material and a substrate material, including:a) a first moving endless surface with a direction of movement (MD) and with one or more of reservoirs, said first moving endless surface and reservoirs thereof being for transferring particulate material to:
b) a second moving endless surface with a direction of movement (MD) carrying a substrate material for receiving said particulate material from said first moving endless surface in a receiving zone and for transferring said combination of said particulate material and said substrate material in a transferring zone, said second moving endless surface being in said receiving zone adjacent a first vacuum chamber and being in gas communication therewith, and said second moving endless surface being in said transferring zone adjacent a second vacuum chamber, and being in gas communication therewith, said receiving zone and said transferring zone being adjacent (in MD) one another,
c) an adhesive application unit for applying adhesive to said combination of said substrate and said particulate material, said adhesive application unit positioned downstream of said first moving endless surface opposite said second moving endless surface and said second vacuum chamber in said transferring zone;
wherein the ratio of the said negative vacuum pressure in said first vacuum chamber to the negative vacuum pressure in said second vacuum chamber is at least 4:3; and
d) an anvil roll downstream of said transferring zone for receiving said combination of said particulate material and said substrate material and combining said combination with a further substrate material.

US Pat. No. 10,188,541

IMMOBILIZING SPLINTS

1. An immobilizing splint for an antecubital intravenous injection site, the splint comprising:a sleeve of a flexible foam material configured to be selectively and removably closed around an elbow of an arm of a patient;
a preformed opening in the sleeve configured to allow visual access to an antecubital fossa of the elbow, wherein the preformed opening has a presized perimeter that is closed and continuous;
at least two straps configured to close the sleeve around the elbow, wherein each strap of the at least two straps includes a hook-and-loop fastener; and
two stiffening members configured to maintain the elbow in an at least substantially extended position when the sleeve is closed around the elbow to prevent a kink in a portion of an intravenous supply tube that underlies the splint when the sleeve is closed around the elbow, wherein the stiffening members are positioned in the sleeve on opposite sides of the preformed opening such that, when the sleeve is closed around the elbow in a position that allows visual access to the antecubital fossa through the preformed opening, the stiffening members are positioned on an anterior side of the arm.

US Pat. No. 10,188,530

PROVISIONAL TIBIAL PROSTHESIS SYSTEM

Zimmer, Inc., Warsaw, IN...

1. A tibial prosthesis system for implantation on a resected surface of a proximal tibia, the tibial prosthesis system comprising:a bearing component having a superior surface and an inferior surface;
a base component having a superior surface and an inferior surface, wherein the base component having a protrusion extending from the superior surface and configured to mate with a recess in the bearing component, the protrusion having a first feature configured to couple with a second feature of the bearing component when the protrusion is inserted into the recess to prevent significant relative movement between the bearing component and the base component in a medial/lateral direction and an anterior/posterior direction, and wherein the first feature and the second feature are configured to allow the bearing component to be movable relative to the base component in a proximal/distal direction; and
a shim component insertable between the inferior surface of the bearing component and the superior surface of the base component, wherein upon insertion the shim component is configured to engage both the bearing component and the base component to restrain the bearing component from significant relative movement in the proximal/distal direction relative to the base component, and wherein the shim component is configured to be disposed between the inferior surface of the bearing component and the superior surface of the base component.

US Pat. No. 10,188,529

DEVICES AND METHODS FOR INTER-VERTEBRAL ORTHOPEDIC DEVICE PLACEMENT

1. An instrument assembly for delivery of an orthopedic implant to a target location within a spinal segment of a subject, comprising:an orthopedic implant;
an implant insertion member comprising a first elongated curvilinear body and an internal bore, at least a portion of said internal bore is extended from a proximal opening to a distal opening along a curvilinear trajectory, said internal bore configured for advancement of said orthopedic implant from said proximal opening to said distal opening; and
a fixation member comprising a first segment configured to attach onto a proximal segment of said implant insertion member, and a second segment configured to attach onto a first surface of said spinal segment, said fixation member configured to limit movement of said implant insertion member relative to said target location in at least one plane;
wherein said orthopedic implant is sized to be advanced from said proximal opening to said distal opening of said internal bore and onto said target location.

US Pat. No. 10,188,525

SPINAL IMPLANT SYSTEM AND METHOD

Warsaw Orthopedic, Inc., ...

1. A spinal implant comprising:a substantially cylindrical member; and
an implant body extending between an anterior surface and a posterior surface, and including a first vertebral engaging surface and a second vertebral engaging surface,
the implant body further including an inner surface that defines a portion of a first cavity and a portion of a second cavity spaced from the first cavity,
the first cavity being oriented to implant a fastener oblique relative to a bilateral axis of a subject body and the second cavity being oriented to implant a fastener in substantial alignment with the bilateral axis,
wherein the inner surface further defines a transverse bore, the member being disposed entirely within the transverse bore, and
wherein the member includes a threaded surface defining a portion of the first cavity and a threaded surface defining a portion of the second cavity.

US Pat. No. 10,188,518

ANNULOPLASTY RING WITH VARIABLE CROSS-SECTION

Edwards Lifesciences Corp...

15. An elongated annuloplasty ring, comprising:an elongated ring body comprising an inner single piece metallic structural support surrounded by a suture permeable interface, the ring body surrounding a central open area through which passes a flow axis and being discontinuous so as to define two free ends at a break in continuity around a periphery of the ring body, wherein the ring body has a relaxed configuration shaped to mimic a three-dimensional path along a non-planar native valve annulus,
wherein the structural support has a radial cross-section that gradually changes around a length of the structural support and has a C-shaped part in a mid-portion, and wherein the two free ends of the structural support are rectangular in radial cross-section and are more flexible in bending about the flow axis than the C-shaped part of the cross-section, and wherein the two free ends of the ring body are axially offset from each other.

US Pat. No. 10,188,512

REVERSIBLE CAVITARY TENSION MEMBRANE

1. An apparatus for supporting and uniformly covering at least in one plane a cavity structure without obstructing the flow of fluid through the cavity structure, the apparatus comprising:an expandable membrane configured to transition between an expanded state and a shrunken state, wherein the membrane is comprised of a first layer and a second layer, the edges of which are joined together to create a closed chamber between the first layer and the second layer, the membrane comprising:
an internal face and an external face opposite the internal face;
a tension mechanism disposed between the internal face and the external face and configured to exert force on the first layer and the second layer to place the expandable membrane in the expanded state;
and at least one orifice disposed between the internal face and the external face, wherein the external face is in fluid communication through the orifice with an empty space defined by the internal face of the membrane when the membrane is in the expanded state.

US Pat. No. 10,188,511

BIOPROSTHETIC TISSUE WITH REDUCED CALCIFICATION

Edwards Lifesciences Corp...

1. A packaged bioprosthetic device comprising:an at least partially cross-linked pericardial tissue comprising functional groups that have been blocked, removed or altered by reacting the functional groups with capping agents, wherein the functional groups are one or both of aldehyde groups and carboxylic acid groups; and
a packaging storing the at least partially cross-linked biological tissue without a liquid preservative solution.

US Pat. No. 10,188,487

DENTAL IMPLANT SUPERSTRUCTURE SUPPORT

1. A superstructure support (20) for disposition as part of a prosthetic tooth replacement (1) between an implantation body (10) and a superstructure consisting of an artificial crown (120) or a composite of a cement body (100) and the crown (120), the superstructure support (20) comprising:a screw insertion opening (61) including three zones extending through from a top surface to a bottom surface of the superstructure support (20);
an upper zone (67) having a cylindrical bore with a centerline (69) proximate to the top surface;
a lower zone (62) having a cylindrical bore with a centerline (63) proximate to the bottom surface;
an intermediate transition zone (64) positioned between the lower and upper zones having an internal conical area (65) coaxial with the centerline (63);
an outer area (51) adjacent the implantation body (10) having an implantation neck (52) including outer cone (53) above which an implant plate (31) is arranged;
a crown-supporting area (21) provided with an engagement structure (41) and an implantation post (23) which includes a screw seating bore (62);
a smooth microstructure surface (71) with an average arithmetic roughness value of 1.5 to 3.0 ?m provided with webs or grooves (74) at least partially extending around the superstructure support (20); and
spaced edges acting as bacteria barriers formed between a plurality of adjacent conical areas arranged on top of one another provided at the bottom side (32) of the implantation plate (31) on top of the implantation neck (52),
wherein an angle in the range of 155 to 178 angular degrees is formed between the centerline (69) of the upper zone and the centerline (63) of the lower zone.

US Pat. No. 10,188,484

SYSTEM OF COMPONENTS OR IMPLEMENTS FOR EASILY AND PRECISELY INSTALLING A DENTAL IMPLANT, AND A METHOD OF INSTALLING THE DENTAL IMPLANT

1. A system for implementing the installation of a winged dental implant within a blind bore implantation site defined within a patient's jaw, comprising:a rotary cutter assembly comprising a rotary cutting disk mounted upon a support post; and
a rotary cutter guide to be disposed within the blind bore implantation site defined within the patient's jaw, wherein said rotary cutter guide comprises a base portion and an upstanding body portion, a first vertically extending through-slot defined within said upstanding body portion of said rotary cutter guide such that said first vertically extending through-slot extends through said rotary cutter guide along a first plane from a first wall portion of said upstanding body portion to a second oppositely disposed wall portion of said upstanding body portion, and a second vertically extending through-slot defined within said rotary cutter guide such that said second vertically extending through-slot extends through said rotary cutter guide along a second plane which is disposed orthogonally with respect to said first plane such that said second slot extends from a third wall portion of said upstanding body portion to a fourth oppositely disposed wall portion of said upstanding body portion,
wherein said support post of said rotary cutter assembly extends through said first vertically extending through-slot defined within said upstanding body portion of said rotary cutter guider while oppositely disposed stub portions of said support post extend outwardly from said oppositely disposed first and second wall portions of said first vertically extending through-slot defined within said upstanding body portion of said rotary cutter guide so as to stably support said rotary cutter assembly within said rotary cutter guide, and opposite sides of said rotary cutting disk project outwardly from said oppositely disposed third and fourth wall portions of said second vertically extending through-slot defined within said upstanding body portion of said rotary cutter guide so as to be capable of cutting oppositely disposed slots within the patient's jaw for accommodating oppositely disposed wing members of the winged dental implant.

US Pat. No. 10,188,476

MEDICAL GOWN HAVING AN INTEGRAL PROTECTIVE SLEEVE FOR MEDICAL EQUIPMENT

1. A protective medical gown comprising:a gown body adapted to be worn by a medical professional, the gown body having a front panel section, the gown body oriented by an exterior surface and an interior surface when worn;
an orifice centrally located in a central region of a front portion of the gown body; and
a tubular protective sleeve joined to the gown body at an attachment end circumscribing the centrally located orifice, the tubular protective sleeve extending freely and outward from the gown body, the tubular protective sleeve having a shape and size to receive a distal portion of a medical device;
an interior pocket separate segment from the tubular protective sleeve assembled to the interior surface of the gown body, the interior pocket comprising a sheet of material joined to the interior surface of the gown body along each of a first edge of the interior pocket and a second edge of the interior pocket, the interior pocket located to support a proximal portion of the medical device, having a first end proximate the centrally located orifice and a second end proximate a neckline of the gown body,
wherein the gown body and tubular protective sleeve are fabricated of a material and assembled to one another creating an impervious barrier to biomedical hazardous materials.

US Pat. No. 10,188,471

TELE-OPERATIVE SURGICAL SYSTEMS AND METHODS OF CONTROL AT JOINT LIMITS USING INVERSE KINEMATICS

INTUITIVE SURGICAL OPERAT...

1. A tele-operation control method comprising:receiving a first manipulation command to move a distal end effector of a manipulator arm to a desired first position within a workspace, the manipulator arm extending between a proximal base and the distal end effector;
calculating a joint movement of one or more joints of a master control corresponding to calculated movement of a plurality of joints of the manipulator arm using inverse kinematics of the manipulator arm; and
when a first joint of the plurality of joints is at a joint range-of-motion (ROM) limit of the first joint, modifying an input variable within the inverse kinematics of the manipulator arm to lock the first joint, wherein the input variable corresponds to movement of the first joint within the workspace so that the calculated joint movement of the one or more joints of the master control provides improved force feedback.

US Pat. No. 10,188,469

INSTRUMENT, MANIPULATOR SYSTEM, AND CONTROL METHOD OF INSTRUMENT

OLYMPUS CORPORATION, Tok...

1. A manipulator system comprising:a medical instrument configured to be inserted into a body;
a manipulator configured to hold a portion of the instrument positioned in the body;
a switch configured to detect whether or not the manipulator holds the portion of the instrument positioned in the body;
an instruction-receiving part configured to detect an instruction for operating the instrument; and
a controller comprising hardware, the controller being configured to operate the instrument based on the instruction from the instruction-receiving part only when the switch detects that the manipulator holds the portion of the instrument positioned in the body,
wherein the switch detects whether or not the manipulator holds the portion of the instrument positioned in the body according to a conduction state and a cutoff state between a pair of contacts,
the switch switches the conduction state and the cutoff state between the pair of contacts by being pressed in a reference direction,
the manipulator has a gripper that grips the switch in the reference direction,
the instrument comprises a first instrument and a second instrument, and the controller is configured to:
operate only the first instrument where the instruction-receiving part detects the instruction when the switch detects whether or not the manipulator holds a portion of the first instrument positioned in the body, and
operate only the second instrument where the instruction-receiving part detects the instruction when the switch detects whether or not the manipulator holds a portion of the second instrument positioned in the body.

US Pat. No. 10,188,465

AUTOMATIC ENT SURGERY PREPLANNING USING A BACKTRACKING MAZE PROBLEM SOLUTION

Biosense Webster (Israel)...

1. A method, comprising:(a) receiving a computerized tomography (CT) scan of at least a part of a body of a patient;
(b) identifying voxels of the scan that correspond to regions in the body;
(c) displaying the scan on a screen and marking thereon selected start and termination points for a probe inserted in the body;
(d) finding a path from the start point to the termination point comprising a connected set of the identified voxels that are traversable by the probe, wherein finding the path comprises determining a set of density data associated with each of the identified voxels, determining a traversable density range, and determining the connected set of the identified voxels based at least upon the set of density data associated with those voxels being within the traversable density range;
(e) using the scan to generate a representation of an external surface of the body and displaying the representation on the screen;
(f) selecting a first region of the representation of the external surface to be transparent, wherein the first region is associated with the path such that the path is viewable through the first region;
(g) selecting a second region of the representation of the external surface to be non-transparent;
(h) rendering the first region transparent in the displayed representation, so as to make visible on the screen an internal structure of the body in a vicinity of the path; and
(i) rendering the second region non-transparent while rendering the first region transparent;
wherein the traversable density range comprises at least one density other than the density of air.

US Pat. No. 10,188,463

BONE LENGTH DETERMINATION

Stryker European Holdings...

1. A method for measuring an actual length of a fractured bone, wherein an implant is already introduced into the fractured bone, wherein a first reference body and a second reference body are already arranged in a predetermined relation to the implant, the method comprising the steps of:receiving a first 2D fluoroscopic image including the first reference body and a first bone feature;
determining a first spatial relation between the first reference body and a first end point at the first bone feature;
receiving a second 2D fluoroscopic image including the second reference body and a second bone feature;
determining a second spatial relation between the second reference body and a second point (P) at the second bone feature;
receiving data of a bone model having corresponding first and second bone features, determining a third spatial relation between the second point (P) of the second bone feature and a second end point (EP1) at the bone model; and
determining the actual length of the fractured bone based on the first, second, and third spatial relation, and on the predetermined relation of the reference bodies to each other.

US Pat. No. 10,188,439

BONE FIXATION SYSTEM

DePuy Synthes Products, I...

1. A bone fixation linkage comprising:first and second links configured to interconnect with one another in an unlocked position such that the first and second links angulate with respect to one another, each link defining a first surface configured to face a bone to which the bone fixation linkage is configured to be attached, a second surface opposite the first surface along a first direction, a first attachment member, a second attachment member spaced from the first attachment member along a second direction, perpendicular to the first direction, a first fixation hole that extends through the first attachment member, and a second fixation hole that extends through the second attachment member, the second fixation hole having a diameter greater than that of the first fixation hole,
wherein the first attachment member of each respective link defines a first geometry at the first surface of the respective link, the second attachment member of each respective link defines a second geometry at the second surface of the respective link, and the first geometry of the first link is configured to interlock with the second geometry of the second link when the first and second links are in a locked position so as to prevent relative angulation between the first and second links, and
wherein the first link has a first interior surface that defines the first fixation hole of the first link, and the first attachment member of the first link has a tapered surface that extends from the first interior surface to the second surface of the first link and surrounds the first fixation hole of the first link.

US Pat. No. 10,188,437

SPINE STABILIZATION

Globus Medical, Inc., Au...

1. A surgical system comprising:an intervertebral device; and
a compression device, wherein the compression device comprises:
a receiver member, the receiver member including a limiter; and
an insert member configured to be received in the receiver member, the insert member including a catch configured to engage the limiter,
wherein the insert member comprises an opening configured to receive a pin,
wherein the receiver comprises a channel configured to engage the pin, and
wherein the pin is configured to travel within the channel to constrain movement of the receiver member relative to the insert member prior to the catch engaging the limiter so that receiver and insert remain in an interconnected state, and
wherein the compression member is configured to allow a dynamic range of compression such that the length of the compression member can increase or decrease following an initial amount of static compression.

US Pat. No. 10,188,433

ANTERIOR CERVICAL PLATES FOR SPINAL SURGERY EMPLOYING ANCHOR BACKOUT PREVENTION DEVICES, AND RELATED SYSTEMS AND METHODS

1. An anterior cervical plate, comprising:a main body including
a front surface,
a rear surface opposite the front surface, wherein the rear surface is configured to face first and second vertebrae, and
inner surfaces connected to the front and the rear surfaces, wherein the inner surfaces form a first anchor passageway and a second anchor passageway through the main body, wherein the first and the second anchor passageways are configured to respectively receive first and second anchors; and
a positioning guide projecting from the rear surface and configured such that, when the rear surface abuts against an anterior surface of the first vertebra and the positioning guide abuts against an endplate of the first vertebra, the positioning guide positively aligns the first anchor passageway relative to a corner edge of the first vertebra and the positioning guide is configured to be free from abutment against the second vertebra,
wherein the positioning guide includes a magnet configured to create a magnetic field.

US Pat. No. 10,188,431

DOUBLE-HEADED PEDICLE SCREW

1. A double-headed pedicle screw comprising:a threaded shaft portion having an upper end, the upper end having a first side and an opposing second side, the first side having a first side protrusion and the opposing second side having a second side protrusion; and
a first yoke assembly extending from the first side of the upper end of the threaded shaft portion;
a second yoke assembly extending from the opposing second side of the upper end of the threaded shaft portion, each of the first and second yoke assemblies including a recess configured to receive a portion of a rod therein, the recess of the first yoke assembly and the recess of the second yoke assembly each having an opening facing in a direction away from the other yoke assembly;
wherein the first side protrusion is configured to receive the first yoke assembly and the second side protrusion is configured to receive the second yoke assembly, the first side protrusion and the second side protrusion aligned along a common axis, each of the first and second yoke assemblies configured for pivoting movement relative to the threaded shaft portion independent of the pivoting movement of the other yoke assembly and wherein the first and second yoke assemblies are configured for pivoting movement in a direction perpendicular to the common axis of the first and second side protrusions.

US Pat. No. 10,188,387

ARTICULATING APPARATUS FOR ENDOSCOPIC PROCEDURES

Covidien LP, Mansfield, ...

1. A surgical device, comprising:an elongate body portion including an inner actuation shaft movably positioned therewithin and repositionable between a first position and a second position, the inner actuation shaft including an engagement member;
an end effector releasably supported adjacent a distal end of the elongate body portion, the end effector including:
an engagement member corresponding to the engagement member of the inner actuation shaft to facilitate releasable connection of the end effector to the elongate body portion, the end effector being releasable from the elongate body portion when the inner actuation shaft is positioned in the second position and secured to the elongate body portion when the inner actuation shaft is positioned in the first position;
a plurality of surgical anchors; and
a pair of opposed longitudinally extending tines defining a pair of opposed longitudinally extending channels; and
an outer tube, wherein the inner actuation shaft is movably positioned within the outer tube, wherein the engagement of the inner actuation shaft is concealed within the outer tube in the first position and exposed from the outer tube in the second position.

US Pat. No. 10,188,374

PNEUMOPERITONEUM DEVICE

Atropos Limited, Bray, C...

1. A method of performing a medical procedure, comprising:excising tissue within a body cavity, wherein the tissue is excised with the body cavity in an insufflated state;
inserting a bag into the body cavity;
delivering the excised tissue into an interior of the bag, wherein the excised tissue is delivered into the interior of the bag through a first access channel of the bag; and
performing a procedure on the tissue in the interior of the bag, wherein the procedure is performed with the bag in an insufflated state and the body cavity in an uninsufflated state, and wherein performing the procedure includes accessing the interior of the bag through the first access channel, accessing the interior of the bag through a second access channel of the bag, and manipulating the tissue in the interior of the bag through at least one of the first and second access channels.

US Pat. No. 10,188,361

SYSTEM FOR SYNTHETIC DISPLAY OF MULTI-MODALITY DATA

Siemens Healthcare GmbH, ...

1. A computer-implemented method for providing a multi-modality visualization of a patient, the method comprising:receiving one or more image datasets, each image dataset corresponding to a distinct image modality;
segmenting the one or more image datasets into a plurality of anatomical objects;
receiving a list of clinical tasks associated with displaying the one or more image datasets;
for each anatomical object, using a machine learning model to determine visualization parameters for the anatomical object based on the list of clinical tasks; and
creating a synthetic display of the one or more image datasets by presenting each anatomical object according to its corresponding visualization parameters.

US Pat. No. 10,188,349

FLOORMAT PHYSIOLOGICAL SENSOR

TOSENSE, INC., San Diego...

1. A system for measuring a cardiac output value from a patient, comprising:a base comprising a bottom surface configured to rest on or near a substantially horizontal surface, and a top surface configured to receive at least one of the patient's feet;
an electrical impedance system connected to the top surface, the electrical impedance system comprising at least four electrodes, at least one of which is configured to inject an electrical current into the patient's feet, and at least one of which is configured to measure a first set of signals induced by the electrical current and representative of an impedance plethysmogram;
a heart rate monitoring system connected to the top surface and comprising at least two electrodes connected to a differential amplifier, the differential amplifier configured to measure a second set of signals representative of a cardiac rhythm from the patient; and
a processing system in electrical contact with the electrical impedance system and the heart rate monitoring system, and configured to: 1) receive the first signals from the electrical impedance system and convert them into a set of impedance values; 2) analyze the set of impedance values to determine a stroke volume value; 3) receive the second set of signals from the heart rate monitoring system and convert them into a set of ECG values; 4) analyze the set of ECG values to determine a heart rate value; and 5) collectively process the stroke volume value and the heart rate value to determine the cardiac output value.

US Pat. No. 10,188,334

SENSITIVITY CALIBRATION OF IN VIVO SENSORS USED TO MEASURE ANALYTE CONCENTRATION

Abbott Diabetes Care Inc....

1. A method, comprising:determining a sample lot sensitivity associated with a plurality of analyte sensors in a manufacturing lot;
determining one or more sensor-specific correction factors for an analyte sensor in the manufacturing lot;
determining a sensor-specific sensitivity for the analyte sensor based on the one or more sensor-specific correction factors; and
calibrating analyte level data obtained by the analyte sensor based on the sensor-specific sensitivity.

US Pat. No. 10,188,325

WEARABLE, NONINVASIVE GLUCOSE SENSING METHODS AND SYSTEMS

1. A wearable apparatus for glucose sensing comprising:(a) a noninvasive glucose sensor, adapted to be in contact with or attached to a target tissue, comprising:
(i) an ultrasound generator configured to direct ultrasound pulses or waves into the target tissue, and
(ii) an ultrasound detector configured to:
(1) detect ultrasound pulses or waves reflected from the target tissue using reflection, focused reflection, refraction, scattering, polarization, transmission, confocal, interferometric, low-coherence, and/or a low-coherence interferometry technique, and
(2) generate a signal corresponding to the detected ultrasound pulses or waves,
(b) a processor configured to:
(i) receive the signal from the ultrasound detector,
(ii) measure:
(1) at least one time of flight of the ultrasound pulses or waves reflected from or transmitted through the target tissue evidencing boundaries or interfaces within the target tissue, and/or
(2) at least one dimension of the target tissue evidencing a specific tissue layer within the target tissue, wherein the dimension includes thickness, length, width, diameter, curvature, or roughness; and
(iii) determine a glucose concentration value from:
(1) the at least one measured time of flight, and/or
(2) the at least one measured dimension, and
(c) a feedback unit including a display and configured to display a current glucose value or a plot of glucose values versus time,
wherein the target tissue is associated with an arm, a forearm, a wrist, a shoulder, a hand, a palm, a finger, an abdomen, a chest, a neck, a head, an ear, an eye, a back, a leg, a foot, or mixtures and combinations thereof, and
wherein target tissue comprises a skin tissue, an eye tissue, a mucosal tissue, a nail bed, a lunula, a connective tissue, a muscle tissue, a blood vessel, a cartilage tissue, a tendon tissue, or mixtures and combinations thereof.

US Pat. No. 10,188,272

IMAGING CAPSULE

1. A capsule, comprising:a cyclically everting sleeve shaped to define a sleeve interior;
a fluid, configured to facilitate the everting of the sleeve, contained within the sleeve interior; and
a plurality of electrically-conductive coils coupled to the sleeve and configured to, when at least two of the coils are magnetized, advance the capsule within a lumen by applying an everting force to the sleeve,
wherein the coils are arranged in a plurality of rings running longitudinally along the sleeve.

US Pat. No. 10,188,266

ENDOSCOPIC IMAGING DEVICE FOR REDUCING DATA AMOUNT OF IMAGE SIGNAL

OLYMPUS CORPORATION, Tok...

1. An imaging device comprising:an image sensor; and
a processor comprising hardware, wherein the processor is configured to:
receive information from an image processing device external to the imaging device, wherein the information indicates that the image processing device is configured to:
receive, in a transmission period defined by the image processing device, an image signal representing a single reading of a subject, illuminated by illumination light, performed by the image sensor; and
generate an observation image of a first type based on the image signal representing the single reading received;
in response to the information received:
control the image sensor to perform a plurality of readings of the subject, illuminated by the illumination light;
generate an image signal representing the plurality of readings, for generating an observation image of a second type,
wherein the processor is configured to control the image sensor, generate the image signal representing the plurality of readings, or both to reduce a data amount of the image signal representing the plurality of readings such that transmission of the image signal representing the plurality of readings to the image processing device is completed within the transmission period; and
control a communication interface to transmit the image signal having the data amount that is reduced to the image processing device within the transmission period.

US Pat. No. 10,188,257

CEILING TEXTURE SCRAPING ASSEMBLY

1. A ceiling texture scraping assembly being configured to scrape and collect texture from a ceiling, said assembly comprising:a pan being configured to be manipulated having said pan being positioned beneath a ceiling, said pan having an outer wall and a pair of peripheral walls, said outer wall having a top side, a bottom side and a back side, said back side tapering to a point extending away from each of said bottom side and said top side, each of said top side and said bottom side having a distal edge with respect to said back side, said distal edge corresponding to each of said top side and said bottom side defining an opening into said pan wherein said opening is configured to receive texture from the ceiling, said bottom side having a length being greater than a length of said top side;
a sleeve being coupled to and extending away from said point parallel to said top side and said bottom side wherein said sleeve is configured to be gripped; and
a blade being coupled to said pan wherein said blade is configured to frictionally engage texture on the ceiling thereby facilitating said blade to remove the texture from the ceiling.

US Pat. No. 10,188,249

VACUUM CLEANER

LG Electronics Inc., Seo...

1. A vacuum cleaner system comprising:a cleaner body that defines a battery chamber;
a motor that is located in the cleaner body and configured to provide a suction force;
a battery that is detachably provided in the battery chamber and configured to provide electric power to the motor;
a battery cover that is rotatably coupled to the cleaner body and configured to open and close the battery chamber; and
a charging stand that is configured to couple to the cleaner body, wherein the charging stand includes an opening prevention rib that is located along an opening path of the battery cover to thereby prevent the battery cover from opening based on the cleaner body being coupled to the charging stand.

US Pat. No. 10,188,226

MODULAR COUNTER SERVICES DISPENSING SYSTEM

San Jamar, Inc., Elkhorn...

1. A food services accessory dispensing system comprising:a first base portion;
a plurality of dispensing containers that are each configured to dispense a different food service accessory, each of the plurality of dispensing containers being constructed to removably cooperate with the first base portion;
a second base portion constructed to removably cooperate with the first base portion and constructed to cooperate with at least one of the plurality of dispensing containers and wherein each alternate lateral end of each of the first base portion and the second base portion have the same shape;
a first opening and a second opening formed in the first base portion;
a first opening and a second opening formed in the second base portion; and
at least one connector having a first end and a second end, wherein the first end is releasably insertable into each of the first and second openings formed in the first base portion or the second base portion and the second end is releasably insertable into each of the first and second openings formed in the first base portion and the second base portion for selectively connecting the first base portion and the second base portion to one another when the connector is engaged with a respective one of the first and second openings in the first base portion and a respective one of the first and second openings in the second base portion when the respective lateral ends of the first base portion and the second base portion are directly adjacent one another.

US Pat. No. 10,188,216

CONVERTIBLE CASE AND STOOL

1. A case convertible into a stool and a working surface, the case comprising:a worktable;
a front panel removably secured to a front side of the worktable;
a rear panel removably secured to a rear side of the worktable; and
a stool seat configured to secure the front and rear panels to the worktable in a carrying mode wherein the case is fully assembled,wherein in a working mode the case is fully disassembled and the front and rear panels are removed from the worktable and interconnected to form a supporting substructure of the stool and the stool seat is removably extended from the first panel of the supporting substructure to the second panel of the supporting substructure to define a sitting surface.

US Pat. No. 10,188,212

BLOW MOLDED RESIN FURNITURE HAVING A STABILIZING BOX STRUCTURE

Suncast Technologies, LLC...

1. A resin furniture assembly comprising:a box structure, formed by a first end structure including a first side panel, having an inner wall, an outer wall, and a plurality of edge walls integrally connected to each other, a second end structure including a first side panel, having an inner wall, an outer wall, and a plurality of edge walls, a front panel, a rear panel, a base panel and a seat panel to include a hollow interior portion, said box structure including a plurality of legs for supporting a bottom surface of said base panel in a spaced apart relationship above a ground surface so that an air gap is maintained between said bottom surface of said base panel and a ground surface, a back panel, said back panel secured to said box structure to form a seat back, said seat panel secured to said box structure for enclosing the top portion of said box structure, at least one of said first end structure, said second end structure, said front panel, said rear panel, or said seat panel being pivotally secured to said box structure for movement between a closed position enclosing said box structure and an open position providing access to an inner portion of said box structure, said inner portion of said box structure providing an enclosed storage area, a rain gutter integrally formed on said inner wall of each said end structure, each said rain gutter providing support to side portions of said seat panel to channel water away from hollow interior portion of said box structure to keep contents stored therein dry;
wherein said seat panel includes a rain gutter bead integrally formed thereto said rain gutter bead cooperating with said rain gutter to channel water away from hollow interior portion of said box structure to keep contents stored therein dry.

US Pat. No. 10,188,198

FINGER RETENTION CLIP

1. A finger retention clip for retaining an object about a user's finger, comprising:a base member adapted for attachment to the object; and
a resilient retaining member attached to the base member, the retaining member forming an open finger loop and being sized and shaped to conform to the user's finger;
wherein the retaining member has a first width, and a second width narrower than the first width;
wherein the retaining member includes a structural feature that selectively provides a stress concentration, such that the retaining member releases from the user's finger in response to a selected force by breaking of the retaining member.

US Pat. No. 10,188,187

PURSE PROTECTING APPARATUS AND ASSOCIATED USE THEREOF

7. A method of utilizing a combined purse and security fastener for securing said purse around a user neck and a user shoulder, thus preventing theft of said purse, while also affording comfort when carrying said purse over the user shoulder, said method comprising the chronological steps of:providing a purse including a storage section and a flexible shoulder strap affixed thereto;
carrying said flexible shoulder strap over a first shoulder of the user such that a weight of said purse is supported on the first shoulder of the user;
providing a security fastener including a flexible chain and a shoulder pad adjustably engaged with said flexible chain;
lifting each of said flexible chain and said shoulder pad up and over a user neck opposite to said first shoulder of the user;
resting said shoulder pad on a second shoulder of the user opposite to said first shoulder of the user such that a weight of said security fastener is supported on the second shoulder of the user;
slidably coupling said security fastener to said flexible shoulder strap by looping a proximal end of said flexible chain through said flexible shoulder strap while holding a distal end of said flexible chain adjacent to said storage section; and
fastening said proximal end of said flexible chain to said distal end of said flexible chain such that said flexible chain rests along a first axis during use and said flexible shoulder strap rests along a second axis during use, wherein said first axis intersects said second axis, wherein said flexible chain overlaps said flexible shoulder strap.

US Pat. No. 10,188,186

DIAPHRAGM GAME CALL CASE

1. A container for housing a diaphragm game call, the container comprising:a case having a first member defining a first interior, and a second member defining a second interior;
a connector that adjoins a portion of said first member to a portion of said second member, so that said first interior and said second interior together define an interior space sized to enclose the diaphragm game call;
a fastener for closing said first member and said second member to enclose said interior space of the container;
a mount directly attached to said first member and being constructed of a water impervious material to prevent fluid from leaking through the mount;
a first compressible moisture-retaining material attached to said mount; and
a second compressible moisture-retaining material attached to said second member, the second compressible moisture-retaining material being comprised of a substantially similar material as the first compressible moisture-retaining material, forming a compression space within the interior space and between said first compressible moisture-retaining material and said second compressible moisture-retaining material, said compression space for storage of the diaphragm game call in contact with and compressed between said first compressible moisture-retaining material and said second compressible moisture-retaining material.

US Pat. No. 10,188,185

SUITCASE

1. A suitcase, comprising:a main body, comprising a containing groove;
a removable compartment, movably located in the containing groove, wherein the removable compartment comprises:
a base layer;
a covering layer, covering the base layer;
at least one hole, located in the base layer;
an inner opening unit, movably connected to the covering layer, wherein the inner opening unit is used for allowing the covering layer to be opened or closed, and the base layer is exposed to the outside when the covering layer is opened;
at least one first main fastening unit, located in the containing groove, wherein the at least one first main fastening unit comprises:
a fastening bar; and
an operating unit, connected to the fastening bar and passing through the at least one hole;
at least one second main fastening unit, located in the containing groove; and
a plurality of fastening rings, connected to the base layer, and a plurality of positions of the plurality of fastening rings respectively correspond to the at least one first main fastening unit and the at least one second main fastening unit.

US Pat. No. 10,188,181

FASTENER STRINGER AND SLIDE FASTENER PROVIDED WITH SAME

YKK Corporation, (JP)

1. A fastener stringer comprising a row of elements and a fastener tape, at least one side edge of the fastener tape having insulation properties, the row of the elements being attached to the one side edge of the fastener tape, wherein each element comprises a pair of leg portions for holding the fastener tape from front and back sides; and a head portion connecting each leg portion while straddling the one side edge of the fastener tape, the head portion having an engaging region for engaging with an opposing element when constructing a fastener chain; and wherein cured coating film is formed in 50% or more of a total number of the elements at least at a center portion in a front and back direction of the fastener tape on an end surface of the head portion.

US Pat. No. 10,188,178

BUCKLE FOR SEATBELT DEVICE

AUTOLIV DEVELOPMENT AB, ...

1. A buckle for a seatbelt apparatus comprising:a buckle stay that has a fixation portion provided at a base end of the buckle stay and adapted to be fixed to a vehicle body, and a coupling plate portion provided at a leading end of the buckle stay and having a first through-hole;
a buckle base having a bottom plate portion and a pair of side plate portions standing up from opposite side edges of the bottom plate portion, the buckle base also having a second through-hole formed at one end of the bottom plate portion, the side plate portions extending in a longitudinal direction along the bottom plate to overlie a longitudinal position of the second through hole;
a support shaft inserted through the first and the second through-holes, the support shaft being loosely inserted through the first through-hole in the coupling plate portion, to allow the buckle base to be coupled to the buckle stay so as to be able to tilt with respect to the buckle stay through a predetermined angle in a first direction perpendicular to a plate surface of the bottom plate portion and further so as to be able to pivot with respect to the buckle stay, through a predetermined angle in a second direction parallel to the plate surface of the bottom plate portion;
an elastic member that when the buckle base tilts in the first direction and pivots in the second direction, urges the buckle stay to return the buckle base from a deflected position to an original position,
the support shaft integrally forming a generally cylindrical shaft main body and a pair of arm portions provided at an upper portion of the support shaft and extending from a longitudinal axis of the main body in opposing lateral directions, a lower end of the support shaft main body is collapsed against a lower surface of the bottom plate portion of the buckle base to fix the support shaft to the buckle base, the arm portions trapping the buckle stay between the arm portions and the buckle base, and
tip portions of the pair of arm portions are coupled into respective engagement grooves formed in the pair of side plate portions of the buckle base, the engagement grooves cooperating with the pair of arm portions to fix a rotational position of the support shaft relative to the buckle base, the support shaft fixed to the buckle base adjacent to the second through-hole to fixedly mount the support shaft to the buckle base bottom plate portion.

US Pat. No. 10,188,165

HEADGEAR CONFIGURED FOR POSITIONING OF SPECTACLES

1. Headgear configured for positioning of spectacles comprising:a first extending portion configured to extend under a chin;
a second extending portion configured for extending about a forward portion of a head;
a third extending portion configured for extending about a reward portion of the head;
a first opening in the second extending portion or third extending portion;
a second opening in the second extending portion or third extending portion;
a third opening in the second extending portion or third extending portion and spaced apart from the first opening;
a fourth opening in the second extending portion or third extending portion and spaced apart from the second opening;
the first opening and the third opening being configured and disposed to receive a first eyeglass temple on a first side of the head; and
the second opening and the fourth opening being configured and disposed to receive a second eyeglass temple on a second side of the head.

US Pat. No. 10,188,162

GARDENING UTILITY TOOL

1. An improved gardening utility tool comprising:a glove having a set of glove fingers and a glove thumb;
a set of finger extensions attached to a trank of the glove configured to have an open arrangement wherein the finger extensions are configured to move independently of each other;
a first portion included in each finger extension having a first resiliency;
a second portion included in each finger extension attached to the first portion having a second resiliency wherein a proof resilience of the second portion is higher relative to the first portion;
a set of pivots connecting each first portion to a corresponding second portion allowing the second portions to rotated about a long axis of the first portions;
a plurality of releasable connections disposed on adjacent side surfaces of the finger extensions wherein each of said finger extensions releasably interlocks with an adjacent said finger extension along said adjacent side surfaces to form a composite tool in which all of said finger extensions are locked together to move and operate together in a fixed arrangement;
a forward edge included in each finger extension having a shape taken from the group consisting of: flat, curved, concave, angled, concave angled, pointed, and any combination thereof; and,
a thumb extension attached to the trank.

US Pat. No. 10,188,154

BRASSIERE UNDERWIRE REPAIR DEVICE

1. A system for repairing a brassiere having a fabric casing encompassing an underwire whose end tip section has poked a hole through the fabric casing, said system comprising:a hollow, elliptic, cylindrically shaped repair sleeve having an open bottom end and an enclosed rounded top end, and an outer layer of thermal adhesive; and
an installation apparatus, separate and independent from the repair sleeve, whereby the repair sleeve is configured to fit over the end tip section of the underwire and the installation apparatus is configured to be installed into the hole between the repair sleeve and an inner surface of the fabric casing to facilitate the installation of the repair sleeve entirely within the fabric casing.

US Pat. No. 10,188,151

INFANT SWADDLING

1. Infant swaddling comprising:a sheet made of a resilient, moisture-wicking material that maintains pressure on an infant and reduces excess moisture within the sheet when in use, the sheet configured to open to lay flat and defined by an outward-facing surface that, when the infant is placed on the sheet, faces away from the infant and an inner-facing surface that, when the infant is placed on the sheet, faces toward the infant, and the sheet comprising
an upper portion adjacent to an upper edge that, when in use, the infant's head extends beyond the upper portion at the upper edge;
a lower portion adjacent to a lower edge, the lower portion spaced apart from the upper portion;
a first laterally extending region adjacent to a first side edge, the outward-facing surface of the first laterally extending region comprising a first attachment having a first length;
a second laterally extending region adjacent to a second side edge, the inner-facing surface of the second laterally extending region comprising a second attachment that is recloseable with and complementary with the first attachment and having a second length, the first length being longer than the second length, wherein the first attachment and the second attachment are configured to allow adjustment to accommodate the infant's growth; and
wherein the lower portion comprises a loop, spaced apart from the lower edge, wherein the loop is fixed closer to the second side edge than the first side edge, wherein to close access through the lower portion, the lower portion is configured to be gathered and passed through the loop, wherein the loop is configured to reduce the possibility of the lower portion creeping during use, and wherein, when first attachment is closed with the second attachment, the lower portion is configured to be opened, allowing access to the infant near the infant's feet or bottom.

US Pat. No. 10,188,149

PLACKET TRUSS AND GARMENT INCORPORATING THE SAME

1. A placket truss for use on a placket having a plurality of buttons sewn thereto with thread, said placket truss comprising:an elongate member including opposed end portions;
a medial clip integral with the elongate member and disposed between said opposed end portions, said medial clip including a bend whereby the medial clip doubles back onto the elongate member and extends in a direction transverse to a length of the elongate member; and
wherein each said end portion includes at least one slot sized and adapted to engage the thread of a corresponding button.

US Pat. No. 10,188,147

ATOMIZATION ASSEMBLY AND ELECTRONIC CIGARETTE

HUIZHOU KIMREE TECHNOLOGY...

1. An atomization assembly configured for forming an electronic cigarette with a battery assembly (4), comprising a suction nozzle assembly (1), an atomization core (2) and an e-liquid cup assembly (3), the atomization core (2) and the suction nozzle assembly (1) are respectively arranged at two ends of the e-liquid cup assembly (3); wherein the e-liquid cup assembly (3) comprises an e-liquid storage sleeve (31) and a vent pipe (32), the vent pipe (32) is arranged in the e-liquid storage sleeve (31) for discharging smoke obtained by an atomization of the atomization core (2) to the suction nozzle assembly (1), an e-liquid storage cavity (33) is formed between the e-liquid storage sleeve (31) and the vent pipe (32), one end of the e-liquid storage sleeve (31) is provided with an open end communicating with the e-liquid storage cavity (33), the atomization core (2) is detachably connected to the e-liquid cup assembly (3) and at least one end of the atomization core (2) is inserted into the e-liquid storage cavity (33) from the open end;wherein the atomization core (2) comprises an atomization sleeve (21) and a heating wire assembly (22), the atomization sleeve (21) is provided with an atomization cavity (211) for receiving the heating wire assembly (22) to atomize e-liquid, and a first e-liquid guide hole (212) allowing the e-liquid in the e-liquid storage cavity (33) to flow into the atomization cavity (211) is defined on a side wall of the atomization sleeve (21); and
wherein the atomization core (2) further comprises an e-liquid inlet control structure (23), the e-liquid inlet control structure (23) is sleeved in the atomization sleeve (21) rotatably or movably in an axial direction of the atomization sleeve (21), openings (233) for mounting the heating wire assembly (22) are arranged on the e-liquid inlet control structure (23), and when the e-liquid inlet control structure (23) is rotated or axially moved, the openings (233) and the first e-liquid guide hole (212) are communicated or completely staggered, so as to open or close the first e-liquid guide hole (212).

US Pat. No. 10,188,127

METHOD FOR PRODUCING FROZEN ICE CREAM PRODUCTS

1. A method for producing frozen ice cream products, using a freezing system comprising a freezing apparatus, said method comprising:placing pre-products to be frozen onto a number of product plates,
conveying pre-products to be frozen into the freezing apparatus,
cooling the pre-products to form frozen products while conveying the pre-products inside the freezing apparatus by exposing them to circulating cold air,
conveying the frozen products out of the freezing apparatus,
measuring one or more surface temperatures of frozen products leaving the freezing apparatus,
using the one or more measured surface temperatures as input for a control device for controlling one or more operational parameters of the freezing apparatus,
lifting the frozen products off the product plates, after conveying them out of the freezing apparatus, by means of a product handling system driven by a driving arrangement, and
measuring one or more torque values exerted by the driving arrangement during the lifting of the frozen products off the product plates, and inputting the one or more measured torque values into a control device for controlling one or more operational parameters of the freezing system.

US Pat. No. 10,188,121

BACTERIOPHAGE TREATMENT FOR REDUCING AND PREVENTING BACTERIAL CONTAMINATION

Ecolab USA Inc., St. Pau...

1. A method of treating and preventing bacterial contamination in a meat food product, the method comprising:applying a bacteriophage treatment to a packaging material as a foam, the bacteriophage treatment comprising:
at least one bacteriophage in a concentration sufficient to reduce or eliminate bacteria selected from the group consisting of pathogenic bacteria, spoilage bacteria, and combinations thereof;
a buffering agent to maintain the bacteriophage treatment at a pH between approximately 4 and 9;
from about 25 ppm to about 2.0 weight percent of a foaming surfactant selected from the group consisting of alcohol ethoxylates, alcohol ethoxylate carboxylate, amine oxides, alkyl sulfates, alkyl ether sulfate, sulfonates, quaternary ammonium compounds, alkyl sarcosines, betaines, alkyl amides and mixtures thereof; and
an adjuvant comprising one or more of calcium, magnesium, a competitive exclusion bacteria, a fatty acid, a terpene, a terpenoid, glycerol, and propylene glycol, and
packaging the food product in the packaging material.

US Pat. No. 10,188,104

COMBINATIONS OF LIPO-CHITOOLIGOSACCHARIDES AND METHODS FOR USE IN ENHANCING PLANT GROWTH

1. A method of enhancing plant growth, comprising treating a plant seed with at least two distinct lipo-chitooligosaccharides (LCOs) to synergistically enhance growth of a plant that germinates from said seed, said at least two distinct LCOs comprising:

US Pat. No. 10,188,097

MEDICAL DEVICE INTENDED FOR THE LONG-TERM STORAGE OF A CORNEA, OR FOR EX VIVO EXPERIMENTATION ON A HUMAN OR ANIMAL CORNEA

UNIVERSITE JEAN MONNET, ...

1. A device for storage of a corneal specimen including a cornea and a sclera ciliary zone, comprising:an intermediate component including a first hole having a diameter matching that of the cornea, the first hole surrounded by a circumferential groove and a first edge, the first hole, groove, and first edge forming a cavity to receive the corneal specimen, the cavity configured to ensure that the corneal specimen is centered when inserted into the device and configured to stabilize the corneal specimen when the device is opened at an operating theater;
an endothelial lid including a second hole having a diameter matching that of the cornea, the second hole surrounded by a second edge configured to trap the corneal specimen by flattening the sclera ciliary zone on the circumferential groove of the intermediate component; and
an epithelial lid;
wherein the intermediate component and the endothelial lid are configured to entrap the sclera ciliary zone in an airtight manner to delimit an endothelial chamber and an epithelial chamber separate from the endothelial chamber;
wherein the endothelial chamber is composed of a space formed between the endothelial lid and the intermediate component after a tight connection of the endothelial lid to the intermediate component;
wherein the epithelial chamber is composed of a space formed between the intermediate component and the epithelial lid after a tight connection of the epithelial lid to the intermediate component;
wherein the intermediate component and the endothelial lid each comprise a respective inlet orifice and a respective outlet orifice, the orifices allowing a preservation medium to circulate through the endothelial chamber and through the epithelial chamber;
the inlet orifice of the endothelial lid being connected to a preservation medium reservoir containing the preservation medium, such that during use the preservation medium contained in the preservation medium reservoir flows into the endothelial chamber from the preservation medium reservoir;
the outlet orifice of the endothelial lid being connected to the inlet orifice of the intermediate component, such that during use the preservation medium contained in the endothelial chamber flows into the epithelial chamber from the endothelial chamber,
the outlet orifice of the intermediate component being connected to a waste reservoir, such that during use the preservation medium contained in the epithelial chamber flows into the waste reservoir from the epithelial chamber,
the connections of the orifices allowing the preservation medium to circulate on both sides of the cornea, firstly in the endothelial chamber and secondly in the epithelial chamber, and allowing the creation of a pressure gradient between the endothelial chamber and the epithelial chamber with overpressure in the endothelial chamber.

US Pat. No. 10,188,096

DEVICE FOR GRIPPING AND REMOVING A BAIT STATION

1. A gripping device for removing a bait station from a ground soil, the bait station having an opening with a dimension, the opening leading to an internal surface with at least two opposing portals on the internal surface, the gripping device comprising:a) a frame comprising a back end piece and a front end piece spaced from each other by connecting sides, wherein the connecting sides define a bottom portion with a handgrip to conform to fingers of a user;
b) a plunger slidably mounted in an opening in the front end piece;
c) a spring connected between the back end piece and plunger for biasing the plunger toward a second extended gripping position from a first retracted position;
d) a first hook fixedly attached to the frame; and
e) a second hook attached to the plunger for movement between the first retracted position and the second extended gripping position,
wherein the first hook and the second hook fit within the dimension of the opening of the bait station when the plunger is in the first retracted position and wherein the first hook and the second hook engage the two opposing portals when the plunger is in the second extended gripping position; and
wherein the plunger has a thumb piece opposite the engagement of the spring with the plunger and wherein the front end piece includes a thumb cover that has a bottom, two sides, and an open top to allow a user's thumb to engage the thumb piece.

US Pat. No. 10,188,095

TREE STAND

1. A tree stand comprising a seating member having:first and second side members, the side members extending substantially parallel with each other with a bend in each of the first and second side members, the first and second side members each having a first end and a second end opposite the first end;
a removable tree attachment member, the removable tree attachment member being a linear member running substantially orthogonal to the first and second side members, spanning from the first side member to the second side member proximate to the first end of the first and second side members;
a fixed tree attachment member, the fixed tree attachment member running substantially orthogonal to the first and second side members, spanning from the first side member to the second side member at a location between the bend and the first end of each of the first and second side members;
first and second angled tree attachment members, the first and second angled tree attachment members interconnecting the fixed tree attachment member with each of the first and second side members, the first and second angled tree attachment members forming an angle with the fixed tree attachment member from about 30 degrees to about 60 degrees;
a fixed seat defining member, the fixed seat defining member running substantially orthogonal to the first and second side members, spanning from the first side member to the second side member proximate to the second end of the first and second side members; and
a seat attached to the side members via a plurality of seat straps, each of the seat straps disposed as loops about the side members, the loops disposed between the fixed tree attachment member and the fixed seat defining member.

US Pat. No. 10,188,092

BREAKAWAY ADAPTER SYSTEM FACILITATING BOTH FRONT-MOUNTED AND REAR-MOUNTED CONFIGURATIONS OF A SPRAYER BOOM

CNH Industrial America LL...

1. A breakaway adapter system facilitating both front-mounted and rear-mounted configurations of a sprayer boom of an agricultural sprayer, wherein the sprayer boom includes a main boom body connected to the agricultural sprayer with the main boom body having outer ends, a sprayer facing side facing toward the sprayer, and an outwardly facing side facing away from the sprayer, wherein the breakaway adapter system comprises:a pair of breakaway boom segments arranged outwardly beyond outer ends of the main boom body;
a pair of breakaway joints arranged between the outer ends of the main boom body and the pair of breakaway boom segments, wherein the breakaway joints are configured to allow the breakaway boom segments to deflect in rearward deflection directions; and
a pair of adapter arrangements between the outer ends of the main boom body and the pair of breakaway joints, each adapter arrangement configured to engage and support either breakaway joint of the pair of breakaway joints;
wherein when the sprayer boom is in the front-mounted configuration, the breakaway joints mount to the adapter arrangements in a first mounting position in which the breakaway joints are arranged to allow the breakaway boom segments to deflect in a deflection direction that is common with a direction faced by the sprayer facing side of the main boom body; and
wherein when the sprayer boom is in the rear-mounted configuration, the breakaway joints mount to the adapter arrangements in a second mounting position in which the breakaway joints are arranged to allow the breakaway boom segments to deflect in a deflection direction that is common with a direction faced by the outwardly facing side of the main boom body.

US Pat. No. 10,188,090

FISH RECEPTACLE

1. A fish receptacle, comprising:a container having a base, one or more upstanding sidewalls, an open upper end, defining an interior volume, the container configured to store water and fish therein;
a lid pivotally connected to the upper end of the container, the lid providing access to the interior volume of the container;
a door assembly disposed on the lid, the door assembly comprising a frame disposed around a perimeter of an aperture disposed through the lid;
wherein the frame is affixed to an upper surface of the lid about the aperture, wherein a front wall, a rear wall, a left wall, and a right wall each extend perpendicularly away from the frame;
a track disposed within the frame, wherein the track comprises two opposing rails disposed within each of the left and right walls of the frame and a slot through the rear wall of the frame;
wherein the door assembly further comprises a sliding member configured for sliding engagement with the track;
wherein the sliding member is movable between an open position to expose the aperture of the door assembly and a closed position to at least partially cover the aperture.

US Pat. No. 10,188,089

DEVICE FOR REMOVING A FISH FROM A LINE

1. A fish removing device, comprising:a first end bending back into a U shaped end configured to engage a fishing line;
the U shaped end extending into a straight section; and
a gripping section connected to the straight section.

US Pat. No. 10,188,079

STRAP FOR ATTACHING A DECORATIVE ORNAMENT TO THE HEAD OF A PET

1. A strap assembly for securing a decorative ornament to a head of an animal, comprising:a chin strap comprising a continuous loop;
a first ear strap for placement around a back of a first ear of the animal;
a second ear strap for placement around a back of a second ear of the animal; and
an ornament attachment device permitting an ornament to be removably attached thereto;
wherein the first ear strap and the second ear strap can be joined together permitting the joined-together ear straps to wrap under the neck of the animal;
wherein the first ear strap and the second ear strap are portions of a single, continuous elongated strip when joined together;
wherein the chin strap is attached to the continuous elongated strip;
wherein the ornament attachment device is attached to the chin strap and the continuous elongated strip at the point where the chin strap and the continuous elongated strip are attached together.

US Pat. No. 10,188,050

VOLUMETRIC BUDGET BASED IRRIGATION CONTROL

Rain Bird Corporation, A...

1. A method of controlling irrigation, the method comprising:receiving water usage information corresponding to a first volumetric water usage at a site location having an irrigation controller configured to implement and control irrigation at the site and comprising valve drivers each configured to activate one or more valves distributed through the site location and an irrigation controller processor configured to implement an irrigation schedule stored in local memory of the irrigation controller, wherein the first volumetric water usage corresponds to volumetric water usage from a beginning of a budget period of time to a first time within the budget period of time;
determining automatically whether a volumetric water budget at the site location will be met for the budget period of time based on at least the first volumetric water usage, the volumetric water budget corresponding to a specified volume of water for use during the budget period of time;
determining automatically, in the event the volumetric water budget will not be met, an adjustment to the irrigation by the irrigation controller, wherein the adjustment comprises a reduction of runtimes of remaining irrigation events scheduled to occur during the budget period of time such that the adjustment substantially spreads a compensation for an amount of water usage that will exceed the volumetric water budget over the remaining irrigation events; and
outputting signaling causing the irrigation controller to control the valve drivers of the irrigation controller to control opening and closing of one or more of the valves at the site location coupled with the irrigation controller in controlling water released through water delivery devices fluidly coupled with a corresponding one of the valves in controlling irrigation at the irrigation site to effect the adjustment.

US Pat. No. 10,188,044

TREE-TRIMMING DEVICE

1. A horticultural tool comprising:a reciprocating shaft, an extension guard and an extensible structure;
wherein the horticultural tool is configured to use with a reciprocating saw;
wherein the reciprocating saw further comprises a reciprocating structure;
wherein the horticultural tool is a bladed device that is adapted for use in cutting a plant;
wherein the horticultural tool is configured to extend the reach of the reciprocating saw;
wherein the reciprocating shaft is configured to connect the extensible structure to the reciprocating saw;
wherein the extensible structure is inserted through the extension guard;
wherein the reciprocating shaft is attached to the reciprocating structure of the reciprocating saw;
wherein the reciprocating shaft includes a spring-loaded button that is used to secure a linking shaft to the reciprocating saw;
wherein the spring-loaded button is biased outwardly via a spring;
wherein the spring-loaded button of the reciprocating shaft interfaces with a button-hole provided on the linking shaft;
wherein the extension guard comprises a guard, a support, and a foot;
wherein the guard is formed in the shape of a frustum of a pyramid wherein the base of the pyramid is attached to the reciprocating saw;
wherein the support is a square structure that forms a frustum surface that is proximal to the apex of the pyramid;
wherein the foot is a structure that attaches to the support such that the foot projects away from the support in a direction away from the reciprocating saw;
wherein the guard comprises a frame;
wherein the frame is the structural framework that forms the pyramidal shape of the guard;
wherein the frame is formed from a plurality of metal shafts;
wherein the support comprises a plurality of rollers, and a plurality of corners;
wherein the support is a square shaped structure;
wherein each of the plurality of corners is a piece of metal;
wherein each of the plurality of corners is used to form a corner of the square shaped structure;
wherein any first corner selected from the plurality of corners is attached to a second corner selected from the plurality of corners by a roller selected from the plurality of rollers.

US Pat. No. 10,188,032

MOWER WITH MOTOR COOLING

KUBOTA CORPORATION, Osak...

1. A ride-on mower comprising:an operator seat;
drive wheels;
steerable wheels;
at least one rotationally driven grass cutting blade;
at least one motor configured to cause rotation of the grass cutting blade;
said at least one motor comprising a motor housing having an axial length that is shorter than half a cross-sectional diameter or width;
a mower deck compromising a blade rotation space defined by an upper surface and a downward extending sidewall, said mower deck housing the grass cutting blade in an interior thereof;
at least one guide member defining an air flow passage along the motor housing, the air flow passage connecting the interior and exterior of the mower deck; and
said at least one guide member being a separately formed member that is mounted to the mower deck and said at least one guide member having an axial length that is shorter than a diameter or cross-sectional width of said at least one guide member,
wherein the guide member guides a cooling air flow that flows outside of the motor housing, said cooling air flow entering from above the guide member, passing downwards axially between the guide member and the motor housing, and then, inside the mower deck, passing radially inwards towards a motor shaft, and
wherein the cooling flow passing radially inwards towards the motor shaft occurs below the upper surface and inside the blade rotation space.

US Pat. No. 10,188,022

ROTATING LIFT SYSTEM AND METHOD

Bestway, Inc., Hiawatha,...

1. A system for placing a load on a vehicle including a vehicle frame, which load-placing system comprises:a load lift assembly having a first, lowered position for connecting to a load, a second, raised position with said load lifted above a level of said vehicle frame, and a third, transport position with said load positioned over and connected to said vehicle frame;
a lift actuator connected to said load lift assembly and configured for moving said load lift assembly between its lowered and raised positions;
a transfer actuator connected to said load lift assembly and configured for moving said load lift assembly between its raised and transport positions axially along said vehicle frame;
said load lift assembly including a lower linkage assembly including a pair of lift arms configured for connecting to two points of said three-point hitch;
said load lift assembly including a top link configured for connecting to a third point of said three-point hitch;
said top link being pivotally pinned to a pair of mounting brackets affixed to said load lift assembly;
a hydraulic reservoir assembly configured to operate said lift actuator and said transfer actuator;
a motor assembly configured to provide power to said hydraulic reservoir assembly;
a control assembly configured to send control signals to said hydraulic reservoir assembly;
a first hydraulic arm connected to a front end of said vehicle frame, said hydraulic arm configured for moving said load lift assembly between said second, raised position in proximity to a rear end of said vehicle frame and said third, transport position in proximity to said front end of said vehicle frame; and
a second hydraulic arm configured to pivot said lower linkage assembly about said lift arm weldment.
US Pat. No. 10,188,131

HYDROCOLLOIDS COPROCESSED WITH CELLULOSIC FIBERS WHEN BEING SHEARED INTO HIGHLY REFINED CELLULOSE

1. A method for refining cellulosic material from parenchymal fiber mass comprising:soaking raw non-refined material from organic fiber plant mass comprising at least 50% by weight of all fiber mass as the parenchymal fiber mass in an aqueous solution with less than 1% NaOH;
draining the raw non-refined material and allowing the raw material to sit for sufficient time to enable cells in the raw non-refined material to form open cells and expand the raw material into an expanded fiber product, the soaking producing soaked raw materials with open cells;
refining the soaked raw material to produce refined material by shearing the soaked raw materials in the presence of at least 10% by weight of hydrocolloid with respect to the weight of the organic fiber plant mass; and
then drying the sheared mixture of highly refined cellulosic fiber and hydrocolloid.
US Pat. No. 10,190,186

METHOD FOR MANUFACTURING A HIGH-STRENGTH GALVANIZED STEEL SHEET HAVING EXCELLENT FORMABILITY AND CRASHWORTHINESS

JFE Steel Corporation, T...

1. A method for manufacturing a high-strength galvanized steel sheet having excellent formability and crashworthiness, the method comprising:hot-rolling a steel slab having a composition containing, by mass %, C: 0.05% or more and 0.5% or less, Si: 0.01% or more and 2.5% or less, Mn: 0.5% or more and 3.5% or less, P: 0.003% or more and 0.100% or less, S: 0.02% or less, Al: 0.010% or more and 0.5% or less, B: 0.0002% or more and 0.005% or less, Ti: 0.05% or less, a relationship of Ti>4N being satisfied, and the balance comprising Fe and inevitable impurities at a finish rolling temperature of an A3 transformation point or higher;
after the completion of finish rolling, subsequently cooling the resulting steel sheet to a coiling temperature at an average cooling rate of 30° C./s or more;
coiling the steel sheet at the coiling temperature of 300° C. or higher and 550° C. or lower to form a hot-rolled steel sheet;
then performing heat treatment on the hot-rolled steel sheet, the heat treatment including heating the hot-rolled steel sheet to an annealing temperature of (A3 transformation point ?20° C.) or higher and (A3 transformation point +80° C.) or lower at an average heating rate of 5° C./s or more in a temperature range of 500° C. or higher and an A1 transformation point or lower, holding the steel sheet at the annealing temperature for 10 seconds or more, then cooling the steel sheet from 750° C. to a temperature range of 100° C. or higher and 350° C. or lower at an average cooling rate of 30° C./s or more, subsequently reheating the steel sheet to a temperature of 300° C. or higher and 600° C. or lower, and holding the steel sheet at the temperature for 10 seconds or more and 600 seconds or less;
then galvanizing the steel sheet, and optionally performing an alloying treatment, such that the high-strength galvanized steel sheet is formed having a microstructure containing 64% or more and 95% or less of tempered martensite in terms of area ratio and 5% or more and 20% or less of retained austenite in terms of area ratio, the tempered martensite having an average grain diameter of 5 ?m or less.
US Pat. No. 10,188,908

POLYAMIDE COMPOSITIONS CONTAINING PLASTICIZERS FOR USE IN MAKING GOLF BALLS

Acushnet Company, Fairha...

1. A golf ball, comprising:a) a core comprising an inner core and outer core layer, the inner core having an outer surface and geometric center and the outer core layer having an outer surface and inner surface; the inner core comprising a polyamide composition and the outer core layer comprising a rubber composition the polyamide composition comprising:
i) about 40 to about 90% by weight polyamide; and
ii) about 10 to about 60% by weight of a plasticizer selected from the group consisting of ethyl oleate and propylene carbonate and blends thereof, the polyamide comprising a blend of transparent and non-transparent polyamides, wherein at least one of the transparent polyamides is a polyether-amide block copolymer, and wherein the center of the inner core and surface of the outer core layer each has a hardness, and the surface hardness of the outer core layer is greater than the center hardness of the inner core; and
b) a cover having at least one layer disposed about the core.
US Pat. No. 10,188,654

USES OF PYRIMIDO-PYRIDAZINONES TO TREAT CANCER

Asana BioSciences, LLC, ...

1. A method of treating a cancer subject, comprising administering to a cancer subject in need thereof, a therapeutically effective amount of a compound 2-(1-(4-((4-(4-hydroxypiperidin-1-yl)phenyl)amino)-5-oxo-5,6-dihydropyrimido[4,5-d]pyridazin-2-yl)piperidin-4-yl)acetonitrile, or a pharmaceutically acceptable salt or ester thereof, wherein:the cancer subject has a recurrent or refractory cancer;
the cancer is a hematopoietic cancer; and
the cancer is refractory to Ibrutinib.
US Pat. No. 10,189,937

FINE POWDER-COATED AMINE AND COMPOSITION CONTAINING SAME

SUNSTAR ENGINEERING INC.,...

1. A fine powder-coated amine comprising a solid amine having a melting point equal to or higher than 50° C. and a mean particle size equal to or smaller than 20 ?m, wherein the fine powder-coated amine has an amount of heat in the second absorption peak measured by a differential scanning calorimeter equal to or less than 220 J/g, and the surface of the solid amine is coated with fine particles having a mean particle size equal to or smaller than 2 ?m.
US Pat. No. 10,190,194

COPPER ALLOY FOR ELECTRONIC AND ELECTRICAL EQUIPMENT, COPPER ALLOY THIN SHEET FOR ELECTRONIC AND ELECTRICAL EQUIPMENT, AND CONDUCTIVE COMPONENT FOR ELECTRONIC AND ELECTRICAL EQUIPMENT, TERMINAL

MITSUBISHI MATERIALS CORP...

1. A copper alloy for electronic and electrical equipment, comprising:more than 2.0 mass % to 36.5 mass % of Zn;
0.10 mass % to 0.90 mass % of Sn;
0.15 mass % to less than 1.00 mass % of Ni;
0.005 mass % to 0.100 mass % of P; and
a balance containing Cu and inevitable impurities,
wherein an atomic ratio Ni/P of an amount of Ni to an amount of P satisfies a relationship of 3.00 an atomic ratio Sn/Ni of an amount of Sn to an amount of Ni satisfies a relationship of 0.10 a strength ratio TSTD/TSLD is 1.10 or more, where strength TSTD is obtained when a tensile test is performed in a direction perpendicular to a rolling direction and strength TSLD is obtained when another tensile test is performed in a direction parallel to the rolling direction.
US Pat. No. 10,188,657

COMPOSITIONS AND METHODS FOR PROPHYLAXIS AND THERAPY FOR MENIERE'S DISEASE

1. A method comprising administering to an individual diagnosed with Meniere's Disease a pharmaceutical composition comprising an effective amount of lamotrigine or a pharmaceutically acceptable salt thereof such that the effective amount of the lamotrigine or the pharmaceutically acceptable salt thereof is sufficient to reduce dizziness that is caused by the Meniere's Disease in the individual, and wherein the lamotrigine or the pharmaceutically acceptable salt thereof is the only bioactive compound in the pharmaceutical composition that is effective to treat the dizziness caused by the Meniere's Disease.
US Pat. No. 10,189,941

POLYCARBONATE COMPOSITIONS CONTAINING POLYETHYLENE WAX

Covestro Deutschland AG, ...

1. A polycarbonate composition comprisingA) polycarbonate
B) oxidized acid-modified polyethylene wax and
D) an inorganic filler,
wherein the oxidized acid-modified polyethylene wax has an acid number of <10 mg KOH/g determined according to JIS K0070, a crystallinity of greater than 60% and less than 90%, a melting point between 90° C. and 130° C. and a viscosity average molar mass determined by viscometry between 1500 g/mol and 5000 g/mol.
US Pat. No. 10,188,660

ANTI-HULRRC15 ANTIBODY DRUG CONJUGATES AND METHODS FOR THEIR USE

AbbVie Inc., North Chica...

1. An anti-huLRRC15 antibody drug conjugate (ADC) comprising an antimitotic agent linked to an anti-huLRRC15 antibody by way of a linker, wherein the ADC has a structure of formula (I):[D-L-XY]n-Ab  (I)
or a salt thereof, wherein:
D is the antimitotic agent;
L is the linker;
Ab is the anti-huLRRC15 antibody;
XY represents a covalent linkage linking linker L to antibody Ab; and
n is an integer ranging from 2 to 8;
wherein
Ab comprises
a VH chain comprising the sequence of SEQ ID NO:16 and a VL chain comprising the sequence of SEQ ID NO:17,
a VH chain comprising the sequence of SEQ ID NO:26 and a VL chain comprising the sequence of SEQ ID NO:27,
a VH chain comprising the sequence of SEQ ID NO:36 and a VL chain comprising the sequence of SEQ ID NO:37,
a VH chain comprising the sequence of SEQ ID NO:46 and a VL chain comprising the sequence of SEQ ID NO:47,
a VH chain comprising the sequence of SEQ ID NO:56 and a VL chain comprising the sequence of SEQ ID NO:57,
a VH chain comprising the sequence of SEQ ID NO:66 and a VL chain comprising the sequence of SEQ ID NO:67, or
a VH chain comprising the sequence of SEQ ID NO:76 and a VL chain comprising the sequence of SEQ ID NO:77.
US Pat. No. 10,190,198

THICK FILM PASTE AND USE THEREOF

E I DU PONT DE NEMOURS AN...

1. A thick film paste composition comprising:(a) inorganic constituents that consist of:
a platinum source that is at least one of a particulate platinum (alloy) or a particulate platinum (alloy)/metal oxide composite, and
at least one metal compound selected from the group consisting of particulate metal oxides and precursor compounds capable of forming a metal oxide on firing, the metal oxide in each case being selected from the group consisting of NiO, SiO2, RuO2, Rh2O3, IrO2, Cu2O, CuO, TiO2, ZrO2, PbO, SnO2, CeO2, Al2O3, MgO, and MnO2; and
(b) an organic vehicle,
and wherein:
the proportion of the at least one metal compound is 0.001 to 1 wt. %, based on the total thick film paste composition; and
the thick film paste composition is capable of being fired to form an electrically conductive metallization that is electrically connected with an electrode on a ceramic sensor substrate.
US Pat. No. 10,189,943

COPOLYMERS SUITABLE FOR MAKING MEMBRANES

BASF SE, Ludwigshafen (D...

1. A copolymer, comprising polyarylene ether blocks and hydrophilic-hydrophobic blocks,wherein:
said hydrophilic-hydrophobic blocks comprise polyisobutene blocks; and
said hydrophilic-hydrophobic blocks comprise polyisobutene blocks with terminal phenolic ether groups, and said phenolic ether groups are etherified with polyalkyleneoxides.
US Pat. No. 10,189,945

METHOD FOR PRODUCING LIGHT-COLOURED TDI-POLYISOCYANATES

Covestro Deutschland AG, ...

1. A method for producing polyisocyanates comprising urethane groups and having APHA colour indices <50 Hazen comprising reacting di- to tetra-valent organic polyhydroxy compounds with excess amounts of toluylene diisocyanate and then removing unreacted excess toluylene diisocyanate to residual contents <0.5 wt. % by distillation, wherein the toluylene diisocyanate has a content of 2-chloro-6-isocyanato-methylcyclohexadienes <5 wt·ppm.
US Pat. No. 10,188,667

PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE OF 4-PREGENEN-11?-17-21-TRIOL-3,20-DIONE DERIVATIVES

ALLERGAN, INC., Irvine, ...

1. A method of treating an ocular condition associated with glucocorticoid and or mineralocorticoid receptor modulation which comprises topically administering to a patient in need thereof, a pharmaceutical composition comprising a therapeutically effective amount of at least one compound selected from:(8S,9S,10R,11S,13S,14S,17R)-17-glycoloyl-11-hydroxy-10,13 -dimethyl-3 -oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl phenylacetate;
(8S,9S,10R,11S,13S,14S,17R)-17-glycoloyl-11-hydroxy-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl butyrate;
(8S,9S,10R,11S,13S,14S,17R)-17-glycoloyl-11-hydroxy-10,13 -dimethyl-3 -oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl propionate;
(8S,9S,10R,11S,13S,14S,17R)-17-glycoloyl-11-hydroxy-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl octanoate;
(8S,9S,10R,11S,13S,14S,17R)-17-Glycoloyl-11-hydroxy-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl hexanoate;
(8S,9S,10R,11S,13S,14S,17R)-17-glycoloyl-11-hydroxy-10,13 -dimethyl-3 -oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl benzoate;
(8S,9S,10R,11S,13S,14S,17R)-17-glycoloyl-11-hydroxy-10,13 -dimethyl-3 -oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl heptanoate;
(8S,9S,10R,11S,13S,14S,17R)-17-glycoloyl-11-hydroxy-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl 2-methylpropanoate; and
(8S,9S,10R,11S,13S,14S,17R)-17-glycoloyl-11-hydroxy-10,13 -dimethyl-3 -oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl cyclopentanecarboxylate,
and further comprising carboxymethylcellulose, sodium phosphate, citrate buffer, and sodium chloride,
and having a pH from about 4.5 to 7.5.
US Pat. No. 10,189,952

DEGRADABLE THIOL-ENE POLYMERS

REGENTS OF THE UNIVERSITY...

21. A method for producing a biocompatible thiol-ene hydrogel, the method comprisingsubjecting a polymerization reaction mixture comprising at least one thiol compound and at least one olefin compound to a radical polymerization reaction under conditions sufficient to produce the biocompatible thiol-ene hydrogel, wherein:
(a) the at least one thiol compound comprises m number of reactive thiol groups;
(b) the at least one olefin compound comprises n number of reactive ene groups; and
(c) each of n and m is an integer of at least 2, provided the sum of n+m is at least 5.
US Pat. No. 10,190,219

ELECTRICAL STEEL SHEET

1. An electrical steel sheet, comprising:a base material of electrical steel; and
an insulating film formed on a surface of the base material,
wherein the insulating film contains a phosphate of one or more selected from the group consisting of Al, Zn, Mg and Ca,
wherein a proportion of an amount by mole (mol) of Fe atoms relative to an amount by mole (mol) of P atoms in the insulating film is not less than 0.30 and not more than 0.65, and
a limit sodium chloride concentration is 0.1 mass % or more,
wherein the limit sodium chloride concentration represents a maximum concentration of the sodium chloride solution with which the electrical steel sheet does not rust when 0.5 ?L liquid droplets of sodium chloride solutions different in concentration are deposited on the surface of the electrical steel sheet having the insulating film and dried, and the electrical steel sheet is held in an atmosphere with constant temperature and humidity of a temperature of 50° C. and a relative humidity of 90% for 48 hours.
US Pat. No. 10,190,226

REACTION PRODUCTS OF HETEROCYCLIC NITROGEN COMPOUNDS POLYEPOXIDES AND POLYHALOGENS

Rohm and Haas Electronic ...

1. A compound comprising a reaction product of one or more heterocyclic nitrogen compounds comprising at least two reactive nitrogen atoms with the proviso that at least one of the reactive nitrogen atoms is in the ring of the one or more heterocyclic nitrogen compounds; one or more polyepoxide compounds and one or more polyhalogen compounds, wherein the one or more polyhalogen compounds have a formula:X1—R13—X2  (VII)wherein X1 and X2 may be the same or different and are halogens chosen from chlorine, bromine, fluorine and iodine, R13 is linear or branched, substituted or unsubstituted (C1-C20)alkyl, or is a moiety having formula:—C(HR14)—R15—C(HR14)—  (VIII)wherein each R14 is independently selected from hydrogen, halogens chosen from chlorine, bromine, fluorine and iodine, linear or branched, substituted or unsubstituted (C1-C18)alkyl, substituted or unsubstituted (C6-C12)cycloalkyl, substituted or unsubstituted (C6-C15)aryl; R15 is linear or branched, substituted or unsubstituted (C1-C18)alkyl, substituted or unsubstituted (C6-C12)cycloalkyl, substituted or unsubstituted (C6-C15)aryl, —CH2—O—(R16—O)d—CH2— where R16 is a substituted or unsubstituted, linear or branched (C2-C10)alkyl and d is an integer of 1-10.
US Pat. No. 10,189,716

ZEOLITE MONOLITH AND METHOD OF MAKING THE SAME, COMPOSITE WITH ZEOLITE MONOLITH AND METHOD OF MAKING THE SAME, AND METHOD FOR INCORPORATING TWO OR MORE ZEOLITE MONOLITHS

1. A method of manufacturing a porous monolithic zeolite structure including the steps of:(a) taking a porous monolithic substrate;
(b) forming one or more zeolites on the substrate; and
(c) substantially or completely removing said substrate.
US Pat. No. 10,189,976

CURABLE COMPOSITION COMPRISING AN ETHYLENE POLYMER, A MONOPEROXYCARBONATE AND A T-ALKYL HYDROPEROXIDE

ARKEMA FRANCE, Colombes ...

1. A curable composition comprising:(a) at least one ethylene polymer,
(b) at least one monoperoxycarbonate, and
(c) from 0.05 to less than 0.4 part by weight of at least one t-alkyl hydroperoxide for 100 parts by weight of constituent (b).
US Pat. No. 10,189,979

NUCLEATED PHTHALATE-FREE PP HOMOPOLYMERS FOR MELT-BLOWN FIBERS

BOREALIS AG, Vienna (AT)...

1. A polypropylene composition suitable for the production of meltblown PP fibers comprising:(A) a propylene homopolymer, produced with a Ziegler-Natta catalyst (ZN-C), and
(B) a polymeric nucleating agent,
wherein the polypropylene composition has
i) a melt flow rate MFR2 (230° C./2.16 kg) measured according to ISO 1133 of 90 to 5000 g/10 min, and
ii) a difference between melting temperature (Tm) and crystallization temperature (Tc), (Tm?Tc) of <45° C., and
wherein the propylene homopolymer has been visbroken and has an MFR2 of 400 to 3000 g/10 min.
US Pat. No. 10,188,698

SAPOSIN C-DOPS: A NOVEL ANTI-TUMOR AGENT

1. A method for decreasing tumor volume in a subject comprising the step of administering to the subject a composition comprisinga phospholipid, wherein the phospholipid is phosphatidylserine;
an isolated saposin C-related polypeptide, wherein the polypeptide has an amino acid sequence at least 85 percent identical to SEQ ID NO: 2 and wherein the polypeptide includes amino acids 24-40 of SEQ ID NO:2; and
wherein the phospholipid forms a nanovesicle incorporating the polypeptide.
US Pat. No. 10,188,702

METHODS AND COMPOSITIONS FOR TREATING HYPOGLYCEMIC DISORDERS

THE TRUSTEES OF THE UNIVE...

1. A method of treating congenital hyperinsulinism in a subject having congenital hyperinsulinism comprising administering to the subject an effective amount of a peptide wherein the amino acid sequence of the peptide consists of the amino acid sequence set forth in SEQ ID NO: 1.
US Pat. No. 10,188,707

ENOLASE 1 (ENO1) COMPOSITIONS AND USES THEREOF

Berg, LLC, Framingham, M...

1. A pharmaceutical composition comprising enolase 1 (Eno1) or a fragment thereof and a muscle targeting peptide, wherein the Eno1 or a fragment thereof and the muscle targeting peptide are in a complex;wherein the Eno1 or a fragment thereof has glycolytic activity and is present in a therapeutically effective amount; and
wherein the muscle targeting peptide is a smooth muscle targeting peptide, a skeletal muscle targeting peptide, or a smooth muscle and skeletal muscle targeting peptide.
US Pat. No. 10,189,993

SILOXANE COMPOSITION AND METHOD FOR PRODUCING SAME

SHIN-ETSU CHEMICAL CO., L...

1. A method of preparing a siloxane composition, comprising:a step of producing a crosslinked organopolysiloxane having a weight-average molecular weight of 5,000 to 300,000,000 and containing 0.1 to 50 moles of silethylene linkages per 1,000 moles of siloxane units by hydrosilylation of an organopolysiloxane having a structure of formula (1) below with an organohydrogenpolysiloxane having a structure of formula (2) below
M?MVi?D?DVi?T?TVi?Q?  (1)
M?MH?D?DH?T?TH?  (2)(wherein M is R3SiO1/2, MVi is R2PSiO1/2, D is R2SiO2/2, DVi is RPSiO2/2, T is RSiO3/2, TVi is PSiO3/2, MH is R2HSiO1/2, DH is RHSiO2/2, TH is HSiO3/2 and Q is SiO4/2, each R being independently an unsubstituted or substituted monovalent hydrocarbon group of 1 to 12 carbon atoms that has no aliphatic unsaturated bonds and P being an alkenyl group represented by —(CH2)a—CH?CH2 (where “a” is 0 or an integer from 1 to 6); and ?, ?, ?, ?, ?, ?, ?, ?, ?, ?, ?, ? and ? are each independently 0 or a positive number, with the provisos that ?, ? and ? are not all 0, ?+?+??2, ?, ? and ? are not all 0, and ?+?+??2) in an amount of solvent that is at least 8 times the combined weight of the polysiloxanes of formulas (1) and (2) and using a platinum group metal compound, andafter obtaining the crosslinked organopolysiloxane using an organic solvent selected from among toluene, hexane, xylene and methyl ethyl ketone as the solvent: adding a low-viscosity organopolysiloxane as a solvent, and distilling off the organic solvent by heating under reduced pressure so as to give a composition that contains no organic solvent.
US Pat. No. 10,190,002

AQUEOUS MULTI-STAGE EMULSION COPOLYMER COMPOSITIONS FOR USE IN JOINERY APPLICATIONS

Rohm and Haas Company, P...

1. An aqueous composition comprising aqueous multistage emulsion copolymer compositions comprising (a) one or more dihydrazide compounds in a total amount of from 0.5 to 4 wt. %, based on the total weight of composition solids, and (b) of one or more aqueous multistage emulsion copolymers containing, as (i) a first stage, an emulsion copolymer having a glass transition temperature (Tg) via differential scanning calorimetry (DSC) of from ?50 to 30° C., and containing, in copolymerized form, from 0.5 to 3.0 wt. % of one or more monoethylenically unsaturated phosphorous acid monomers and, from 0.75 to 5 wt. % of one or more keto group containing amide monomers, and, as (ii) a second stage, an emulsion copolymer having a DSC Tg of from 50° C. to 125° C., wherein the Tg difference between the first stage and the second stage is from 45° C. to 150° C. having a weight ratio of (i) the first stage to (ii) the second stage, based on copolymer solids, ranging from 50:50 to 90:10 or, all monomer wt. % s based on the total weight of monomers used to make the aqueous multistage emulsion copolymer, and, further wherein, the (ii) second stage of the aqueous multistage emulsion copolymer comprises, in copolymerized form, no more than 25 wt. % of the total monoethylenically unsaturated phosphorous acid monomers used to make the aqueous multistage emulsion copolymer, and no more than 50 wt. % of the total keto group containing amide monomers used to make the aqueous multistage emulsion copolymer, and wherein (b) at least one of the one or more aqueous multistage emulsion copolymer comprises, in copolymerized form, at least 90 wt. % of the one or more monoethylenically unsaturated phosphorous acid monomers in the (i) first stage.
US Pat. No. 10,188,723

FUNCTIONAL INFLUENZA VIRUS LIKE PARTICLES (VLPS)

NOVAVAX, INC., Gaithersb...

1. A vaccine comprising an influenza VLP, wherein said VLP comprises influenza proteins, wherein the influenza proteins consist of M1, HA and NA proteins; wherein the M1 protein is derived from a different influenza virus strain than the HA and NA proteins; wherein the influenza proteins are insect-cell expressed, and wherein the M1 protein is from an avian influenza strain.
US Pat. No. 10,188,984

PROCESS FOR REMOVING OXIDISABLE GASEOUS COMPOUNDS FROM A GAS MIXTURE BY MEANS OF A PLATINUM-CONTAINING OXIDATION CATALYST

1. A process for catalytic oxidative removal of at least one oxidisable gaseous compound from a gas mixture, the gas mixture comprising the at least one oxidisable gaseous compound as well as oxygen, the process comprising:reacting H2Pt(OH)6 with oxalic acid in an aqueous solution to form platinum oxalate complexes of the formula (H3O)1.6[Pt(C2O4)2]. 2H2O;
forming an oxidation catalyst by adding the platinum oxalate complexes to a porous catalyst support and exothermically decomposing the platinum oxalate complexes to generate catalytically active platinum species; and
oxidizing the gas mixture with the oxidation catalyst, wherein
the gas mixture is not a combustion flue gas.
US Pat. No. 10,188,729

MODULATION OF TUMOR IMMUNITY

1. A method of treating a tumor in a patient comprising administering to the patient a bispecific antibody comprising(i) a first arm having a light chain (LC) variable region that comprises the amino acid sequences of CDR-L1, CDR-L2 and CDR-L3 of an LC variable region having the amino acid sequence of the LC variable region of MK-3475 and a heavy chain (HC) variable region that comprises the amino acid sequences of CDR-H1, CDR-H2 and CDR-H3 of an HC variable region having the amino acid sequence of the HC variable region of MK-3475; and
(ii) a second arm having an LC variable region that comprises the amino acid sequences of CDR-L1, CDR-L2 and CDR-L3 of an LC variable region having the amino acid sequence set forth in SEQ ID NO: 82 wherein residue 31 is Q and residue 57 is Q; and an HC variable region that comprises the amino acid sequences of CDR-H1, CDR-H2 and CDR-H3 of an HC variable region having the amino acid sequence set forth in SEQ ID NO: 81.
US Pat. No. 10,193,094

ORGANIC LIGHT-EMITTING DEVICE HAVING DELAYED FLUORESCENCE

Merck Patent GmbH, (DE)

1. An organic electroluminescent device comprisinganode,
cathode,
at least one emitting layer which comprises a luminescent organic compound E which has a difference between the energies of its S1 and T1 states of not greater than 0.15 eV, and
2, 3, 4 or 5 layers H each having a thickness of greater than 2 nm which are arranged between one emitting layer of said at least one emitting layer, which is closest to said anode, and said anode,
where the following conditions apply to each layer H:
a difference D between the HOMO energy level of a layer H and the HOMO energy level of the closest layer having a thickness of greater than 2 nm on a cathode side of this layer H must be less than or equal to 0.4 eV, and
each of the layers H comprises at least one triarylamino compound which is a small organic molecule,
with the proviso that, for layers whose HOMO energy level has a value of less than ?6.7 eV, the LUMO energy level for the said condition occurs instead of the HOMO energy level and wherein the emitting layer which comprises compound E additionally comprises one or more matrix materials, and in that compound E is an emitting compound and the energy of the T1 state of the matrix material of the emitting layer is at most 0.1 eV lower than the energy of the T1 state of compound E.
US Pat. No. 10,190,020

SILOXANE-BASED COATINGS CONTAINING POLYMERS WITH UREA LINKAGES AND TERMINAL ALKOXYSILANES

The United States of Amer...

8. A composition comprising:an amine-functional compound or an epoxy- or acrylate-functional compound; and
a urea-containing composition made by a method comprising:
reacting an amino-functional alkoxysilane with a first polyisocyanate to form one or more adducts having an unreacted isocyanate group; and
reacting the adducts with one or more polyfunctional amino- and/or hydroxyl compounds and a second polyisocyanate to form the urea-containing composition;
wherein the urea-containing composition comprises at least two residues of the polyfunctional amino- and/or hydroxyl compounds;
wherein isocyanate groups do not react with other isocyanate groups; and
wherein the urea-containing composition contains no unreacted isocyanate groups;
wherein the urea-containing composition is characterized by any of:
a) at least one of the polyfunctional amino- and/or hydroxyl compounds comprises an amino group and at least one of the polyfunctional amino- and/or hydroxyl compounds comprises a hydroxyl group;
b) at least one of the polyfunctional amino- and/or hydroxyl compounds is a polyfunctional amino compound; and
c) the urea-containing composition comprises one of more compounds having the formula:
{[(R1O)aR13-aSi—(CH2)3—NR2—CO—NH]n—R3—NH—CO—X—R5—X—CO—NH}m—R3
wherein each a is independently selected from 1, 2, or 3;
wherein m is 2 or 3;
wherein each n is independently selected from 1 or 2;
wherein each X is independently selected from —NR4— and —O—;
wherein each R1 group is an independently selected alkyl group;
wherein each R2 and R4 is independently selected from hydrogen, aryl, alkyl, cycloalkyl, ester-containing aliphatic, ester-containing fluorinated aliphatic, amide-containing aliphatic, and polysiloxane;
wherein each R3 is an independently selected residue of an aliphatic, cycloaliphatic, or aromatic polyisocyanate having 2 or 3 isocyanate groups; and
wherein each R5 independently comprises a group selected from aliphatic, cycloaliphatic, aromatic, polyester, polyether, polysulfide, polyurethane, polycarbonate, polysiloxane, and any combination thereof moisture-curing the composition.
US Pat. No. 10,193,097

LIGHT-EMITTING ELEMENT, LIGHT-EMITTING DEVICE, AND ELECTRONIC DEVICE

Semiconductor Energy Labo...

10. A light-emitting element comprising:a first electrode;
a hole-injecting layer over the first electrode
a hole-transporting layer over the hole-injecting layer;
a light-emitting layer over the hole-transporting layer;
an electron-transporting layer over the light-emitting layer;
an electron-injecting layer over the electron-transporting layer;
a second electrode over the electron-injecting layer;
a first layer between the hole-transporting layer and the light-emitting layer; and
a second layer between the light-emitting layer and the electron-transporting layer,
wherein:
the light-emitting layer includes a first phosphorescent compound,
the first layer includes a first hole-transporting material and a first electron-transporting material,
the second layer includes a second hole-transporting material and a second electron-transporting material,
the second hole-transporting material includes a second phosphorescent compound,
in the first layer, a concentration of the first hole-transporting material is higher than that of the first electron-transporting material,
in the second layer, a concentration of the second electron-transporting material is higher than that of the second hole-transporting material, and
a difference between a wavelength of a highest peak of an emission spectrum of the second phosphorescent compound and a wavelength of a highest peak of an emission spectrum of the first phosphorescent compound is within 30 nm.
US Pat. No. 10,188,740

MODIFIED FC MOLECULES

AMGEN INC., Thousand Oak...

1. A composition of matter comprising:(i) a monomeric or multimeric Fc domain having a cysteine or non-canonical amino acid substitution at one or more specifically selected conjugation site(s) selected from D46, S48, H49, E50, E53, K55, D61, G62, Q76, Y81, K107, K121, G122, Q123, E126, R136, D137, T140, K141, N142, E169, N170, N171, K173, L179, S181, G183, D194, K195, R197, Q199, Q200, G201, N202, or S223, relative to reference sequence SEQ ID NO:599; and
(ii) at least one additional functional moiety, wherein the functional moiety is conjugated to the Fc domain through the side chain of the cysteine residue or non-canonical amino acid residue substituted at said one or more conjugation site(s).
US Pat. No. 10,189,766

PROCESS FOR PRODUCING 2-ETHYLHEXANAL HELPING TO IMPROVE YIELD

NAN YA PLASTICS CORPORATI...

1. A process for producing 2-ethylhexanal helping to increase yield of 2-ethylhexanal, comprises the following steps:1) placing a reaction liquid containing 60-100 wt % of 2-ethyl-2-hexenal into a single reaction tank having internally equipped with a gas-introducing mixer which comprising a hollow rotatory shaft thereof and vanes at a terminal of the hollow rotatory shaft for use in introducing and exhausting hydrogen gas to the reaction liquid and simultaneously stirring the reaction liquid if started;
2) based on the weight of 2-ethyl-2-hexenal, adding a palladium on carbon catalyst ranged from 0.02 wt % to 15 wt % for hydrogenation, whose palladium component is supported on a carbon carrier having a total content of impurities less than 8% by weight of the carbon carrier, and whose specific surface area of the impurities of the carbon carrier is ranged between 800 m2/g and 3,000 m2/g;
3) introducing hydrogen gas to 80-600 lb/in2 and holding this pressure;
4) activating the gas-introducing mixer to stir the reaction liquid at room temperature and held the pressure for 10 minutes, heating to 70-150° C., and allowing hydrogenation for 1-10 hours at this temperature; and
5) upon completion of the reaction, cooling the reaction liquid to room temperature and filtering out the catalyst to obtain a yield of the 2-ethylhexanal at least up to 98.0%.
US Pat. No. 10,191,303

MULTIFOCAL BIMODULUS CONTACT LENSES

NexisVision, Inc., Menlo...

1. An ophthalmic lens for correcting presbyopia of an eye, the eye having a cornea characterized by a refractive shape extending across an optical region of the cornea, the ophthalmic lens comprising:an inner optic portion and a peripheral portion disposed radially outward of the inner optic portion, wherein,
the inner optic portion is configured to be disposed over the optical region of the cornea;
the inner optic portion is characterized by an inner rigidity and the peripheral portion is characterized by a peripheral rigidity;
the inner rigidity is greater than the peripheral rigidity; and
the inner rigidity is from about 1E8 MPa-?m3 to about 1E11 MPa-?m3; and
an anterior surface and a posterior surface opposite the anterior surface, wherein,
a portion of the anterior surface is configured to correct presbyopia; and
the posterior surface is configured to provide one or more lenticular volumes between the posterior surface and the optical region of the cornea.
US Pat. No. 10,189,767

PROCESS FOR MANUFACTURING SUCCINIC ACID FROM A FERMENTATION BROTH USING NANO FILTRATION TO PURIFY RECYCLED MOTHER LIQUOR

DSM IP ASSETS B.V., Heer...

1. A process for manufacturing succinic acid comprising:a) providing an aqueous solution of succinic acid;
b) crystallizing the succinic acid from the aqueous solution to form intermediate crystals and a mother liquor;
c) separating the intermediate crystals from the mother liquor;
d) treating the mother liquor by nanofiltration;
e) recycling the treated mother liquor to b);
f) purifying the intermediate crystals; and
g) recovering succinic acid.
US Pat. No. 10,191,048

FLUOROMETRIC IMMUNOASSAY FOR DETECTION OF ANTI-DSDNA ANTIBODIES

1. A fluorometric immunoassay method for detecting antibodies against double-stranded DNA (anti-dsDNA), comprisingproviding decomplemented sera from a patient, providing isolated dsDNA as antigens from a source,
Precipitating immune complexes with a saturated solution of ammonium sulfate or solution of polyethylene glycol (PEG), wherein the immune complexes are a consequence of incubation of decomplemented patient's sera with the dsDNA,
separating the immune complexes into two samples,
labeling the samples by adding fluorescent dyes specific to the dsDNA to the samples, and
detecting of fluorescence in the samples, namely sample with supernatant and sample with precipitate, comprising immune complexes comprising dsDNA and anti-dsDNA,
wherein the detected fluorescence is a consequence of binding of fluorescent dyes into the dsDNA.
US Pat. No. 10,188,744

AMPHIPATHIC PEPTIDE

1. An amphipathic cell penetrating peptide of less than 50 amino acid residues comprising at least 6 arginine residues (R), at least 12 alanine residues (A), at least 6 leucine residues (L), optionally at least one cysteine residue (C) and at least two but no greater than three glutamic acids (E) whereinthe arginine (R) residues are evenly distributed along the length of the peptide;
the ratio of arginine (R) to negatively charged glutamic acid (E) residues is from at least 6:2 to 9:2; and
the ratio of hydrophilic amino acid residues to hydrophobic amino acid residues at pH 7 is at least 30:67 to 40:60; or
wherein the peptide comprises or consists of WEARLARALARALARELARALARALRACEA (SEQ ID No. 4).
US Pat. No. 10,190,026

WOOD ADHESIVE

INDUSTRIAL TECHNOLOGY RES...

1. A wood adhesive, consisting of:a first agent, consisting of:
a sodium carboxymethyl cellulose having a molecular weight between 15,000 and 500,000 and a degree of substitution of from 0.4 and 2.00 of the sodium salt; and
a styrene-butadiene rubber polymer; and
a second agent, consisting of:
a polymeric quaternary amine and NaOH, wherein a ratio of the weight of the styrene-butadiene rubber polymer to the sum of weights of the sodium carboxymethyl cellulose and the polymeric quaternary amine is in the range from 0.05:1 to 1:0.1.
US Pat. No. 10,190,027

HOT MELT ADHESIVE

1. A hot melt adhesive comprising:(A) 1-15 wt % of a polar functional group-modified conjugated diene-based polymer;
(B) 10-50 wt % of a butyral resin;
(C) 5-40 wt % of an olefin-based polymer;
(D) 5-70 wt % of a tackifier resin; and
(E) 10-40 wt % of a wax.
US Pat. No. 10,188,747

METHODS AND COMPOSITIONS FOR THE TREATMENT OF CANCER

The General Hospital Corp...

1. A method of treating squamous cell carcinoma in a subject in need of treatment thereof, the method comprising administering to the subject an agonist of a gene selected from the group consisting of:Esr2; Dlx5; and Egr3.
US Pat. No. 10,189,772

MIXTURES OF CHELATING AGENTS INCLUDING AN L-ENANTIOMER-RICH MGDA, AND PROCESS FOR MAKING SUCH MIXTURES

BASF SE, Ludwigshafen (D...

1. A mixture, comprising:(A) 90 to 99.9% by weight of a mixture of L- and D-enantiomers of methyl glycine diacetic acid (MGDA) or its respective mono-, di- or trialkali metal or mono-, di- or triammonium salts, said mixture containing predominantly the respective L-enantiomer with an enantiomeric excess (ee) in the range of from 10 to 99%, and
(B) in total 0.1 to 10% by weight of a diacetic acid derivative of at least one amino acid selected from the group consisting of valine, leucine, isoleucine, and tyrosine, as free acids or respective mono-, di- or trialkali metal or mono-, di- or triammonium salts,
wherein the percentages refer to the sum from (A) and (B).
US Pat. No. 10,190,029

REMOVABLE POLYURETHANE HOT MELT ADHESIVE AND THE USE THEREOF

1. A removable reactive hot melt adhesive comprising a (meth)acrylate polymer and an isocyanate-functional polyurethane prepolymer, wherein the (meth)acrylate polymer has a number average molecular weight from about 25000 g/mol to about 60000 g/mol and is selected from a copolymerization product of butyl acrylate and methyl methacrylate as monomers having a melting point of from about 100° C. to about 120° C., a copolymerization product of butyl methacrylate and methyl methacrylate as monomers having a melting point about 110° C., and combinations thereof; andwherein the cured adhesive has a bond strength of about 5.0 MPa or greater at room temperature and a bond strength of about 0.8 MPa or less at a temperature of about 70° C. to about 90° C.
US Pat. No. 10,188,748

PHARMACEUTICAL COMPOSITION CONTAINING A STABILISED MRNA OPTIMISED FOR TRANSLATION IN ITS CODING REGIONS

1. A cell-free mRNA pharmaceutical composition comprising at least one modified mRNA and a pharmaceutically compatible carrier, wherein the modified mRNA encodes at least one human tumour-specific antigenic polypeptide capable of stimulating an immune response in a patient against the human tumour-specific antigenic polypeptide wherein said modified mRNA encoding the human tumour-specific antigenic polypeptide has been stabilized by increasing its Guanosine/Cytosine (G/C) content by at least 7 percentage points relative to that of the wild type mRNA encoding the tumour-specific antigenic polypeptide.
US Pat. No. 10,188,750

SELF-REPLICATING CELL SELECTIVE GENE DELIVERY COMPOSITIONS, METHODS, AND USES THEREOF

University of South Flori...

1. A polyribonucleotide comprising:a RNA molecule of interest (ROI), wherein the ROI is an RNA capable of being translated into p27;
a microRNA (miRNA) target sequence, wherein the miRNA target sequence is a target for miR-126, and wherein the miRNA target sequence is operatively linked to the ROI; and
a RNA molecule capable of being translated into a viral RNA replicase, wherein the RNA molecule capable of being translated into a viral RNA replicase is operatively linked to the ROI, the miRNA target sequence, or both the ROI and miRNA target sequence.
US Pat. No. 10,191,056

DIAGNOSTIC EVALUATION OF ANTIBODY RESPONSES TO COMMONLY RECOGNIZED PROSTATE CANCER-ASSOCIATED ANTIGENS

Wisconsin Alumni Research...

1. An antigen panel for identifying immunoreactivity associated with a premalignant or malignant prostate, the panel comprising antigens encoded by SEQ ID NO:5, SEQ ID NO:10, SEQ ID NO:12, SEQ ID NO:17, SEQ ID NO:18, SEQ ID NO:19, SEQ ID NO:20, SEQ ID NO:24, SEQ ID NO:25, SEQ ID NO:32, SEQ ID NO:34, SEQ ID NO:35, SEQ ID NO:40, SEQ ID NO:44, SEQ ID NO:64, SEQ ID NO:68, SEQ ID NO:72, SEQ ID NO:76, SEQ ID NO:78, SEQ ID NO:80, SEQ ID NO:86, and SEQ ID NO:91, the encoded antigens being immobilized on one of a membrane, a plate, and a filter, and having a positive likelihood ratio of at least 4.
US Pat. No. 10,189,008

ODOR AND COLOR STABLE WATER-ABSORBING COMPOSITION

Evonik Degussa GmbH, Ess...

1. A water-absorbing composition comprising at least: i) from 91.2 to 98.9 wt % of at least one water-absorbing polymer; ii) from 1 to 8 wt % of at least one oxidizing agent; and iii) from 0.1 to 0.75 wt % of at least one inhibitor to inhibit free-radical polymerizations; wherein the inhibitor is a hydroquinone or a hydroquinone derivative selected from the group consisting of hydroquinone, hydroquinone monomethyl ether (HQME), 1,4-dimethoxybenzene, 4,4?-oxydiphenol and a mixture of two or more thereof; and wherein the weight quantities are each based on the overall weight of the water-absorbing composition.
US Pat. No. 10,188,752

DUAL-MODALITY IMAGING PROBE FOR COMBINED LOCALIZATION AND APOPTOSIS DETECTION OF STEM CELLS

The Board of Trustees of ...

1. A dual-modality imaging probe for simultaneous, one-stop, cell apoptosis detection and stem cell tracking, comprising: ferumoxytol with a fluorescent signature peptide immobilized on the surface of the ferumoxytol, wherein the fluorescent signature peptide is a KKKKDEVD-AFC peptide (SEQ ID NO:1).
US Pat. No. 10,189,778

PROCESS FOR THE PREPARATION OF METHIONINE ALPHA-HYDROXY ANALOGUES FROM SUGARS AND DERIVATIVES THEREOF

1. A process for the preparation of a methionine ?-hydroxy analogue and derivatives thereof of the formula:R?—S—CH2—CH2—CHOH—COO—R  (I)wherein R is selected from the group consisting of H, C1-C8 alkyl, alkaline or alkaline-earth metals; and R? is selected from the group consisting of H and methyl; andwherein the process comprises a step of contacting one or more sugars or derivatives thereof selected from the group consisting of glucose, fructose, galactose, mannose, sucrose, xylose, erythrose, erythrulose, threose, glycolaldehyde, methyl vinyl glycolate,vinyl glycolic acid and 2-hydroxyl-?-butyrolactone with a metallo-silicate zeotype material, in the presence of a compound comprising sulphur and a solvent, wherein the metallo-silicate zeotype material has a framework structure selected from the group consisting of BEA, MFI, FAU, MOR, and FER, with a metal and/or metal oxide component.
US Pat. No. 10,189,779

METHODS FOR PRODUCING THIOL COMPOUNDS AND SULFIDE COMPOUNDS USING DIPHENYLAMINE OR A PHENOL COMPOUND

Chevron Phillips Chemical...

1. A process for producing a thiol compound, the process comprising:i) contacting:
a) an olefin compound;
b) H2S;
c) diphenylamine and/or a phenol compound comprising BHT, carvacrol, 2,2?-ethylidene-bis(4,6-di-tert-butylphenol), pentaerythritol tetrakis(3,5-di-tert-butyl-4-hydroxyhydrocinnamate), or any combination thereof; and
d) a photoinitiator and/or a free radical initiator; and
ii) forming the thiol compound.
US Pat. No. 10,188,757

CROMOLYN DERIVATIVES AND RELATED METHODS OF IMAGING AND TREATMENT

The General Hospital Corp...

1. A method for treating Alzheimer's disease in a subject in need thereof comprising the steps of:a) administering to the subject by oral inhalation a dry powder formulation consisting essentially of 17.1 mg of micronized cromolyn sodium, 12.8 mg lactose monohydrate, and 0.6 mg micronized magnesium stearate; and
b) administering orally to the subject 1 mg, 2 mg, 5 mg, 10 mg, or 25 mg of a non-steroidal anti-inflammatory drug,
wherein Alzheimer's Disease is treated in the subject.
US Pat. No. 10,189,271

NON-FOAMING AQUEOUS PARTICLE-FREE INKJET INK COMPOSITIONS

EASTMAN KODAK COMPANY, R...

1. An aqueous colorless particle-free inkjet ink composition that has a viscosity of less than 5 centipoises (0.005 N-sec) at 25° C., and comprises:an anionic polyether polyurethane having an acid number of at least 50 and an anionic acrylic polymer or anionic styrene-acrylic polymer having an acid number of at least 50; wherein the weight ratio of the anionic polyether polyurethane to the anionic acrylic polymer or anionic styrene-acrylic polymer is from 1:9 to and including 9:1, and the total amount of the anionic polyether polyurethane and the anionic acrylic polymer or anionic styrene-acrylic polymer is less than or equal to 20 weight % based on the total aqueous colorless particle-free inkjet ink composition weight, and
a defoamer that has a hydrophilic-lipophilic balance value of at least 3 and up to and including 5, which defoamer is present in an amount of at least 0.15 weight % and up to and including 1 weight %, based on the total aqueous colorless particle-free inkjet ink composition weight.
US Pat. No. 10,188,760

MODULATION OF IMMUNITY AND CEACAM1 ACTIVITY

1. A method for diagnosing a cancer in a human patient, said method comprising the step of contacting a biological sample derived from said patient with a CEACAM1 binding agent conjugated to a detectable moiety, wherein the CEACAM1 binding agent comprises a multimer agent consisting of at least two peptides selected from the group consisting of GYSWYK (SEQ ID NO:33), NRQII (SEQ ID NO:34), and QNDTG (SEQ ID NO: 35).
US Pat. No. 10,190,045

NANO-COMPOSITE STRUCTURE AND PROCESSES MAKING OF

1. A nano-composite structure comprising a nano-composite material having an amorphous matrix with embedded nano-crystallites, wherein the amorphous matrix and the nano-crystallites are made of the same chemical elements, wherein the nano-composite structure exhibits no distinguishable crystalline grain boundaries between the amorphous matrix and the nano-crystallites, wherein the nano-composite structure comprises multiple layers of nano-composite material, the multiple layers of nano-composite material disposed one directly on top of another in direct contact, and wherein each of the nano-composite layers consists of the nano-composite material.
US Pat. No. 10,189,792

METHOD AND APPARATUS FOR SYNTHESIZING A WATER-SOLUBLE HEXAARYL BIIMIDAZOLE

1. A method for forming a water-soluble hexaaryl biimidazole, comprising the steps of:a) reacting benzil with a carboxy benzaldehyde and ammonium acetate to yield a carboxy triaryl imidazole; and
b) dimerizing said carboxy triaryl imidazole in an alkaline aqueous solution of potassium ferricyanide to yield a water-soluble salt of a bicarboxy hexaaryl biimidazole,
wherein said water-soluble salt of a bicarboxy hexaaryl biimidazole is the disodium salt of 2,2?-bicarboxy hexaaryl biimidazole.
US Pat. No. 10,193,132

SYNTHESIS OF SUBMICROMETER TO MICROMETER-SIZED CATHODE MATERIALS

Washington University, S...

1. A method of producing submicrometer- to micrometer-sized, spherical-shaped cathode materials for lithium ion batteries, the method comprising:dissolving a lithium salt and a metal salt in water, alcohol, oil or a mixture of any two or more thereof, forming a lithium metal precursor solution,
spraying the precursor solution to form fine aerosolized droplets,
flowing the aerosolized droplets in a carrier medium into a pyrolysis hydrogen flame producing submicrometer- to micrometer-sized spherical lithium-metal-oxide particles in a range of from about 0.1 ?m to about 100 ?m, wherein no external heat source is required, and wherein the droplets are flowing in an environment having a temperature of less than 1200° C., wherein the submicrometer- to micrometer-sized spherical-shaped lithium-metal-oxide particles produced have a formula of Li?M??O? wherein ? is 0???1; ? is 0???2; and ? is 0???4; and wherein M? is selected from the group consisting of Ni, Co, Mn, Al, Mg, Fe, Cu, Zn, V, Mo, Nb, Cr, Si, Ti, Zr, and a mixture of any two or more thereof.
US Pat. No. 10,188,774

METHOD FOR PRODUCING ANTITHROMBOTIC COATING MATERIAL

TERUMO KABUSHIKI KAISHA, ...

1. A method for producing an antithrombotic coating material, the method comprising:preparing a methanol solution containing a monomer consisting of methoxymethyl acrylate, methoxyethyl acrylate (MEA), ethoxymethyl acrylate, ethoxyethyl acrylate, methoxymethyl methacrylate, methoxyethyl methacrylate, ethoxymethyl methacrylate, ethoxyethyl methacrylate, or a combination thereof;
adding a radical polymerization initiator having a 10-hour half-life temperature of 60° C. or less to the methanol solution to prepare a polymerization reaction liquid, wherein the radical polymerization initiator having a 10-hour half-life temperature of 60° C. or less is 2,2?-azobis(4-methoxy-2,4-dimethylvaleronitrile); and
polymerizing the monomer to form a polymer, wherein the monomer used to form the polymer consists of methoxymethyl acrylate, methoxyethyl acrylate (MEA), ethoxymethyl acrylate, ethoxyethyl acrylate, methoxymethyl methacrylate, methoxyethyl methacrylate, ethoxymethyl methacrylate, ethoxyethyl methacrylate, or a combination thereof.
US Pat. No. 10,193,138

GLASS-FIBER CONTAINING COMPOSITE MATERIALS FOR ALKALI METAL-BASED BATTERIES AND METHODS OF MAKING

Johns Manville, Denver, ...

1. A method of making a glass-fiber composite, the method comprising the steps of:forming a wet laid non-woven glass fiber substrate, wherein the glass fiber substrate comprises a sodium-based compound selected from the group consisting of NaMnO2; NaNiO2; Na(Ni0.5Mn0.5)O2, NaFePO4, Na2Fe2(SO4)3, and Na2Mn11[Mn11(CN)6]; and contacting alkali-metal containing particles on the substrate.
US Pat. No. 10,189,808

SOLID FORMS OF 2-(4-CHLOROPHENYL)-N-((2-(2,6-DIOXOPIPERIDIN-3-YL)-1-OXOISOINDOLIN-5-YL)METHYL)-2,2-DIFLUOROACETAMIDE, AND THEIR PHARMACEUTICAL COMPOSITIONS AND USES

Celgene Corporation, Sum...

1. A solid form of 2-(4-chlorophenyl)-N-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)-2,2-difluoroacetamide or a tautomer thereof, which is Form C having an X-ray powder diffraction pattern comprising peaks at about 16.7, 16.9, 17.7 or 24.7 degrees 2?.
US Pat. No. 10,189,811

METHOD FOR PREPARING THE ANHYDROUS CRYSTALLINE FORM OF ISONIAZID-DERIVED HYDRAZONE, THUS PRODUCED CRISTALLINE POLYMORPH OF THE ANHYDROUS FORM, USE THEREOF FOR THE TREATMENT OF ALZHEIMER'S DISEASE, PARKINSONISM AND OTHER NEURODEGENERATIVE DISORDERS, AND PH


US Pat. No. 10,190,071

STABILIZED BLENDS CONTAINING FRICTION MODIFIERS

The Lubrizol Corporation,...

1. A composition comprising:(a) a medium comprising a solvent, a functional fluid, an additive concentrate or combinations thereof; and
(b) a friction modifier component comprising a condensation product of tartaric and/or citric acid and a linear or branched fatty alcohol of 10 to 18 carbon atoms wherein said condensation product is not fully soluble in the medium; and
(c) a stabilizing component comprising a dispersant that is soluble in (a) and that interacts with (b) such that the solubility of (b) in (a) is improved, wherein said stabilizing component is present at about 4% to about 8% by weight of said composition;
wherein component (b) is present in component (a) in the form of dispersed particles wherein no more than 10 percent by weight of the particles have a diameter of more than 0.5 microns;
wherein component (b) is present in the overall composition at a level of 2 to 4 percent by weight;
wherein component (c), the stabilizing component, comprises: (i) a nitrogen-containing dispersant comprising a reaction product of a hydrocarbyl-substituted succinic acylating agent and a polyamine; (ii) a borated nitrogen-containing dispersant comprising a reaction product of a hydrocarbyl-substituted succinic acylating agent and a polyamine which is borated; (iii) an alkyl imidazoline derived from a polyalkylene amine and a fatty mono-carboxylic acid; or combinations thereof;
wherein a N:CO ratio of (i) or (ii) ranges from greater than 1.3:1 to about 2:1; and
wherein a TBN, as defined by ASTM D4739, of (iii) is greater than 9.
US Pat. No. 10,190,072

METHOD FOR IMPROVING ENGINE FUEL EFFICIENCY

EXXONMOBIL RESEARCH AND E...

1. A method for improving fuel efficiency and reducing frictional properties, while maintaining or improving deposit control, in an engine lubricated with a lubricating oil by using as the lubricating engine oil a formulated oil, said formulated oil having a composition comprising:from 75 to 95 wt % of lubricating oil base stock selected from the group consisting of a Group I base stock, a Group II base stock, a Group III base stock, a Group IV base stock, a Group V base stock and combinations thereof;
a friction modifier mixture comprising a polymeric ethoxylated fatty acid ester having a molecular weight of greater than or equal to 2000 at from 0.1 to 1.0 wt. % of the weight of the lubricating engine oil and an organic molybdenum containing friction modifier contributing from 80 ppm to 500 ppm of elemental molybdenum based on the weight of the lubricating engine oil, and
an overbased calcium salicylate detergent contributing from 200 ppm to 2000 ppm of elemental calcium based on the weight of the lubricating engine oil;
wherein the remainder of the lubricating engine oil includes one or more other lubricating oil additives;
wherein fuel efficiency and friction reduction properties are improved (mini-traction machine (MTM) in Stribeck mode friction coefficient at 140° C. less than or equal to 0.20) and deposit control is maintained or improved (TEOST 33C total deposits less than or equal to 30 mg) as compared to friction reduction properties and deposit control achieved using the same lubricating engine oil not containing the friction modifier mixture and the overbased calcium salicylate detergent.
US Pat. No. 10,192,641

METHOD OF GENERATING A DYNAMIC PATHWAY MAP

The Regents of the Univer...

1. A processor-based method of generating a dynamic pathway map (DPM), comprising:accessing a model database that stores a probabilistic pathway model that comprises a plurality of pathway elements;
assigning an influence level for at least one pathway of a first number of the plurality of pathway elements on the basis of known attributes;
cross correlating the first number of the plurality of pathway elements;
assigning an influence level for at least one pathway on the basis of assumed attributes;
measuring a patient sample to identify measured attributes of the patient sample, based on a genome-scale assay;
modifying the probabilistic pathway model by using a plurality of the measured attributes for a plurality of elements of the patient sample, via an analysis engine, the modifying comprising:
obtaining a factor graph representing states of entities in a cell and interactions between the entities, wherein the factor graph encodes a state of the cell using a random variable for each entity and wherein the factor graph has reference pathway activity information for a particular pathway, the reference pathway indicating deviations from the probabilistic pathway model; and
formulating a treatment option for the patient based on the reference pathway activity of the factor graph, wherein at least one of the above method operations is performed through a processor.
US Pat. No. 10,190,086

METHODS OF PITCHING YEAST FOR FERMENTATION, AND RELATED METHODS OF FERMENTATION AND SYSTEMS

POET Research, Inc., Sio...

1. A method of pitching yeast for fermentation, the method comprising:providing a first aqueous composition in a first fermentation reactor, wherein the first aqueous composition comprises:
yeast;
a slurry comprising water and a processed plant material comprising an amount of at least one monosaccharide; wherein the processed plant material comprises corn flour and the slurry further comprises one or more enzymes that can break down starch in the corn flour into glucose;
fermenting the first aqueous composition in the first fermentation reactor to form a first beer composition comprising alcohol;
providing a fraction of the first beer composition to a second fermentation reactor, wherein the first beer composition in the first fermentation reactor comprises an alcohol at a concentration of at least 15 percent by volume when the fraction of the first beer composition is removed from the first fermentation reactor, and wherein the fraction of the first beer composition comprises a fraction of the yeast and the alcohol;
combining a slurry with the fraction of the first beer composition in the second fermentation reactor to form a second aqueous composition in the second fermentation reactor, wherein the slurry comprises water and a processed plant material comprising an amount of at least one monosaccharide; wherein the processed plant material comprises corn flour and the slurry further comprises one or more enzymes that can break down starch in the corn flour into glucose; and
distilling the first beer composition from the first fermentation reactor to recover alcohol.
US Pat. No. 10,191,366

ETCH VARIATION TOLERANT OPTIMIZATION

ASML Netherlands B.V., V...

1. A method to improve a lithographic process for imaging a portion of a design layout onto a substrate using a lithographic projection apparatus and for transferring the imaged portion of the design layout to the substrate by an etching process, the method comprising:determining a value of an evaluation point of the lithographic process for each of a plurality of variations of the etching process;
computing, by a hardware computer system, a multi-variable cost function of a plurality of design variables that are characteristics of the lithographic process, wherein the multi-variable cost function is a function of a deviation from the determined values of the evaluation point; and
reconfiguring one or more of the characteristics of the lithographic process by adjusting one or more of the design variables and re-evaluating the cost function, until a termination condition for the cost function is satisfied.
US Pat. No. 10,191,371

UNDERLAYER COMPOSITION AND METHOD OF IMAGING UNDERLAYER

ROHM AND HAAS ELECTRONIC ...

1. An underlayer comprising:an acid sensitive copolymer comprising:
an acid decomposable group;
an attachment group; and
a functional group; and
a photoacid generator,
where the functional group is operative to adjust neutrality of the acid-sensitive copolymer relative to a self-assembling block copolymer that is to be disposed on the underlayer, where the neutrality means that a surface energy of the underlayer is substantially the same as that of at least one block of the block copolymer;
wherein the attachment group is covalently bonded to a hydrophilic surface of a substrate by alkoxide linkages where the attachment group comprises a thiol, a primary or secondary amine substituted, a straight chain or branched C1-30 alkyl, a C3-30 cycloalkyl, a C6-30 aryl, a C7-30 alkaryl, a C7-30 aralkyl, a C1-30 heteroalkyl, a C3-30 heterocycloalkyl, a C6-30 heteroaryl, a C7-30 heteroalkaryl, a C7-30 heteroaralkyl, or a combination comprising at least one of these groups; and wherein the acid decomposable groups are ester groups, acetal groups, ketal groups, or pyrocarbonate groups.
US Pat. No. 10,190,092

PROCUREMENT OF PLACENTAL STEM CELLS

1. A method for collecting stem cells from a placenta obtained after childbirth, the method comprising:draining cord blood from the placenta obtained after childbirth;
collecting the drained cord blood in a first collection;
infusing the drained placenta with a first solution, the first solution consisting of a placental preservative base solution and prostaglandin, wherein the placental preservative base solution consists of NaCl, KCl, glucose, citric acid, adenine, histidine, glutamate, glutathione, and N-acetyl-L-cysteine;
infusing the placenta with a second solution before the first solution is collected, the second solution consisting of said placental preservative base solution, a stem cell releasing agent, an antibiotic, and an anticoagulant, wherein the stem cell releasing agent is 1, 1?-[1,4-phenylenebis (methylene)]-bis-1,4,8,11-tetraazacyclotetradecane or a pharmaceutically acceptable salt thereof;
waiting for a predetermined amount of time as the first and second solutions perfuse the placenta, wherein said predetermined amount of time is 5 minutes or fewer; and
collecting, in a second collection, said first and second solutions from the placenta, wherein the collected first and second solutions comprise stem cells from the placenta.
US Pat. No. 10,191,373

METHOD FOR PRODUCING POLYMER

SHIN-ETSU CHEMICAL CO., L...

1. A method for producing a polymer comprising recurring units having an acid generator bound to the backbone, comprisingpolymerizing monomers corresponding to the recurring units in a solution of a non-polymerizable compound containing at least one nitrogen atom to which at least one acid labile group is bound.
US Pat. No. 10,193,171

FUEL CELL WITH INTEGRATED WATER MANAGEMENT LAYER AND FABRICATION METHOD THEREOF

1. Fabrication method of a fuel cell comprising the following successive steps:providing a substrate comprising:
at least one membrane-electrode assembly, formed by an electrolytic membrane arranged between a first electrode and a second electrode,
a first current collector arranged on the first electrode,
depositing a fluoropolymer solution on the first current collector,
making a solvent of the fluoropolymer solution evaporate so as to form a porous thin layer of fluoropolymer.
US Pat. No. 10,190,096

METHODS FOR GENERATING STEM CELL-DERIVED ? CELLS AND USES THEREOF

President and Fellows of ...

1. A method for generating stem cell-derived ? (SC-?) cells, the method comprising contacting a cell population comprising endocrine progenitor cells under conditions suitable to direct differentiation of said endocrine progenitor cells into said SC-? cells with an effective amount of an agent that decreases the level and/or activity of c-Jun N-terminal kinase (JNK), thereby generating said SC-? cells, wherein the endocrine progenitor cells comprise PDX1+/NKX6.1+/NEUROD1+/insulin+/glucagon?/somatostatin? cells.
US Pat. No. 10,190,097

METHOD AND COMPOSITION FOR INDUCING HUMAN PLURIPOTENT STEM CELLS

The Regents of the Univer...

1. A method of pluripotency reprogramming, comprising:treating a human cell with a cell culture medium comprising fibromodulin (FMOD) for a period ranging from a day to a month, and
changing the cell culture medium regularly until a FMOD reprogrammed (FreP) cell forms;
wherein the FreP cell expresses NANOG and does not form teratoma, and
wherein the human cell is a fibroblastic cell.
US Pat. No. 10,192,661

R—T—B BASED SINTERED MAGNET

TDK CORPORATION, Tokyo (...

1. A R-T-B based sintered magnet, wherein:R contains Y and R1,
Y is yttrium,
R1 is at least one rare earth element except Y but contains Nd, and
T represents at least one transition metal element containing Fe or a combination of Fe and Co,
a ratio of R1 to Y (R1:Y) in a grain boundary phase is 73:27 to 55:45 in terms of a calculated molar ratio of the grain boundary phase.
US Pat. No. 10,188,052

MAIZE PLANTS WITH IMPROVED PATHOGEN RESISTANCE

Monsanto Technology LLC, ...

1. A method of obtaining a corn plant with improved tar spot complex (TARSC) resistance, said method comprising:a) providing a population of corn plants;
b) obtaining at least one DNA sample from at least one plant within said population;
c) detecting in the DNA sample the presence of a TARSC resistance allele comprising a “T” at nucleotide position 61 of SEQ ID NO: 6 in, or genetically linked to, a chromosomal segment between about 3.99 cM and about 17.7 cM on chromosome 10;
d) selecting one or more plants from said population based on the presence of said allele;
e) crossing at least one selected plant comprising said allele with a second corn plant that comprises one or zero TARSC resistance alleles to produce one or more progeny plants that produce seeds;
f) collecting the seeds produced by the one or more progeny plants; and
g) growing from said seeds at least one plant having said allele and having improved TARSC resistance.
US Pat. No. 10,190,103

POLYPEPTIDES HAVING GLUCURONYL ESTERASE ACTIVITY AND POLYNUCLEOTIDES ENCODING SAME

1. A method for degrading or hydrolyzing a cellulosic material, comprising: contacting the cellulosic material with an enzyme composition and an isolated polypeptide having glucuronyl esterase activity to thereby degrade or hydrolyze the cellulosic material, wherein the isolated polypeptide having glucuronyl esterase activity is selected from the group consisting of:(a) a polypeptide comprising an amino acid sequence having at least 90% sequence identity to the amino acid sequence of amino acids 101 to 474 of SEQ ID NO: 2;
(b) a polypeptide encoded by a polynucleotide that hybridizes under high stringency conditions with the full-length complement of the nucleotide sequence of nucleotides 33 to 1457 of SEQ ID NO: 1, wherein the high stringency conditions are defined as prehybridization and hybridization at 42° C. in 5×SSPE, 0.3% SDS, 200 micrograms/ml sheared and denatured salmon sperm DNA, and 50% formamide, and washing three times each for 15 minutes using 2×SSC, 0.2% SDS at 65° C.;
(c) a polypeptide encoded by a polynucleotide comprising a nucleotide sequence having at least 90% sequence identity to the nucleotide sequence of nucleotides 33 to 1457 of SEQ ID NO: 1; and
(d) a fragment of the amino acid sequence of amino acids 101 to 474 of SEQ ID NO: 2, wherein the fragment has glucuronyl esterase activity.
US Pat. No. 10,188,053

HYBRID TOMATO VARIETY 72-195 RZ

RIJK ZWAAN ZAADTEELT EN Z...

1. A Solanum lycopersicum plant designated 72-195 RZ, representative seed of which having been deposited under NCIMB Accession No. 42734.
US Pat. No. 10,190,105

HBV POLYMERASE MUTANTS

Transgene S.A., Illkirch...

1. A mutant polypeptide which comprises a mutated HBV polymerase domain with an internal deletion that functionally disrupts the polymerase activity, wherein said internal deletion is of at least 4 amino acid residues and at most 30 amino acid residues, wherein said mutated polymerase domain comprises the amino acid sequence shown in SEQ ID NO:1 but lacks at least the Tyr residue in position 203, the Met residue in position 204, the Asp residue in position 205 and the Asp residue in position 206, the Val residue in position 207, the Val residue in position 208, and the Leu residue in position 209.
US Pat. No. 10,188,058

SWEET CORN HYBRID SVSK6143 AND PARENTS THEREOF

Seminis Vegetable Seeds, ...

1. A corn plant comprising at least a first set of the chromosomes of corn line SHY-6S15-9078LP or corn line SHY-6RHBE322, a sample of seed of said lines having been deposited under ATCC Accession Number PTA-124211 and ATCC Accession Number PTA-124212, respectively.
US Pat. No. 10,188,059

SOYBEAN VARIETY 5PUWT62

MONSANTO TECHNOLOGY LLC, ...

1. A plant of soybean variety 5PUWT62, wherein a sample of seed of said variety has been deposited under ATCC Accession No. PTA-125158.
US Pat. No. 10,190,110

ENGINEERED BOTULINUM NEUROTOXIN

PRESIDENT AND FELLOWS OF ...

1. A nucleic acid comprising a nucleotide sequence that encodes a polypeptide comprising a modified receptor binding domain of Clostridial botulinum serotype B, wherein the modified receptor binding domain comprises an amino acid substitution of M, Q, T or I at the amino acid position E1191 of the polypeptide of SEQ ID NO: 4, wherein the substitution produces enhanced binding of the modified receptor binding domain to human Syt II as compared to an identical molecule lacking the substitution.
US Pat. No. 10,188,061

SOYBEAN VARIETY 01064486

Monsanto Technology LLC, ...

1. A plant of soybean variety 01064486, wherein representative seed of said soybean variety have been deposited under ATCC Accession No. PTA-124958.
US Pat. No. 10,190,112

METHOD FOR THE BIOCATALYTIC CYCLIZATION OF TERPENES AND CYCLASE MUTANTS EMPLOYABLE THEREIN

BASF SE, Ludwigshafen am...

1. An enzyme mutant with cyclase activity which is a mutant of a wild-type enzyme comprising the amino acid sequence of SEQ ID NO: 209 with a mutation at a position corresponding to position F445 of the amino acid sequence of SEQ ID NO: 209, wherein up to 10% of the amino acid residues in said enzyme mutant are altered relative to the amino acid sequence of SEQ ID NO: 209 by deletion, insertion, substitution, addition, inversion, or a combination thereof, and wherein said enzyme mutant catalyzes at least the cyclization of a citronellal isomer to at least one isopulegol isomer.
US Pat. No. 10,188,064

PLANTS AND SEEDS OF HYBRID CORN VARIETY CH246236

Monsanto Technology LLC, ...

1. A seed of hybrid corn variety CH246236, produced by crossing a first plant of variety CV462675 with a second plant of variety CV507905, wherein representative seeds of said varieties CV462675 and CV507905 are deposited under ATCC Accession Nos. PTA-124501 and PTA-123822, respectively.
US Pat. No. 10,190,115

METHODS AND COMPOSITIONS FOR NUCLEIC ACID ANALYSIS

Bio-Rad Laboratories, Inc...

1. A composition comprising a plurality of second partitions containing first partitions, wherein:a. said first partitions are degradable upon the application of a stimulus to said first partitions such that contents of a first partition is mixed with contents of a second partition; and
b. said first partitions are contained within the second partitions;
c. said first partitions contain an oligonucleotide barcode; and
d. the first partitions have on average a first average volume and the second partitions have on average a second average volume, wherein the second average volume is at least twice as large as the first average volume.
US Pat. No. 10,188,066

MAIZE HYBRID X03M280

PIONEER HI-BRED INTERNATI...

1. A seed of hybrid maize variety X03M280, representative seed produced by crossing a first plant of variety PH42YG with a second plant of variety PH2DPY, wherein representative seed of the varieties PH42YG and PH2DPY have been deposited under ATCC Accession Numbers PTA-124780 and PTA-124001, respectively.
US Pat. No. 10,188,067

MAIZE HYBRID X08M611

PIONEER HI-BRED INTERNATI...

1. A seed of hybrid maize variety X08M611, representative seed produced by crossing a first plant of variety PH41R5 with a second plant of variety PH4257, wherein representative seed of the varieties PH41R5 and PH4257 have been deposited under ATCC Accession Numbers PTA-124793 and PTA-124803, respectively.
US Pat. No. 10,191,398

ELECTROPHOTOGRAPHIC PHOTOCONDUCTOR, IMAGE FORMING APPARATUS, AND PROCESS CARTRIDGE

Ricoh Company, Ltd., Tok...

8. An electrophotographic photoconductor, comprising:a conductive support having a volume resistivity of 1×1010?·cm or less;
an undercoat layer; and
a photoconductive layer,
wherein the undercoat layer and the photoconductive layer being disposed on the conductive support in an order mentioned,
wherein the undercoat layer comprises:
zinc oxide particles;
a urethane bond-containing resin; and
methylethyl ketone oxime,
wherein an amount of the methylethyl ketone oxime included in the undercoat layer is from 2,888 ppm to 5,000 ppm, and
wherein the undercoat layer satisfies a formula below:
10 where M is a ratio (ppm) of the methylethyl ketone oxime comprised in the undercoat layer, and L is an average thickness (?m) of the undercoat layer.
US Pat. No. 10,188,068

MAIZE HYBRID X08M612

PIONEER HI-BRED INTERNATI...

1. A seed of hybrid maize variety X08M612, representative seed produced by crossing a first plant of variety PH41V8 with a second plant of variety PH2SRH, wherein representative seed of the varieties PH41V8 and PH2SRH have been deposited under ATCC Accession Numbers PTA-124794 and PTA-124300, respectively.
US Pat. No. 10,190,119

MITOCHONDRIAL PHOSPHATE CARRIER TARGETS FOR TREATING SOFT-TISSUE CALCIFICATION

1. A method of treating soft-tissue calcification in a coronary artery or heart valve in a subject, the method comprising administering a therapeutically-effective amount of an inhibitor of solute carrier family 25 member 24 (SLC25A24) to the subject, wherein the SLC25A24 inhibitor comprises at least one small interfering RNA (siRNA) comprising a targeting sequence selected from the group consisting of: CAGAUGAAUUCACGGAAGA (SEQ ID NO: 1), GCAUAUGAACAGUACAAGA (SEQ ID NO: 2), GGAAAUGGUACAAACGUCA (SEQ ID NO: 3), and GGUGCUGUCUCUCGAACAA (SEQ ID NO: 4) wherein the SLC25A24 inhibitor decreases the expression level of SCL25A24.
US Pat. No. 10,188,072

SOYBEAN VARIETY 01064694

Monsanto Technology LLc, ...

1. A plant of soybean variety 01064694, wherein representative seed of said soybean variety have been deposited under ATCC Accession No. PTA-124971.
US Pat. No. 10,188,074

SOYBEAN VARIETY 5PKCF87

PIONEER HI-BRED INTERNATI...

1. A plant or a seed of soybean variety 5PKCF87, representative seed of the variety having been deposited under ATCC Accession Number PTA-125527.
US Pat. No. 10,188,075

SOYBEAN VARIETY 5PKDS07

PIONEER HI-BRED INTERNATI...

1. A plant or a seed of soybean variety 5PKDS07, representative seed of the variety having been deposited under ATCC Accession Number PTA-125528.
US Pat. No. 10,188,589

DEPOSITION OF HYDROPHOBIC ACTIVES IN THE PRESENCE OF SURFACTANTS

Dow Global Technologies L...

1. A personal care composition, comprising:an anionic surfactant; and
a polyurea shell encapsulating a hydrophobic personal care active selected from the group consisting of a fragrance, a vitamin, an extract, or a therapeutic active, wherein the polyurea shell has at least one covalently attached cationic polymer, selected from the group consisting of quaternary amines and cationic biopolymers, wherein the polyurea shell has at least one covalently attached quaternary amine that is the reaction product of (2-Aminoethyl) trimethylammonium chloride and polyisocyanate.
US Pat. No. 10,189,871

TRANSITION METAL COMPLEXES FOR ENANTIOSELECTIVE CATALYSIS OF CARBON-CARBON, CARBON-HETEROATOM, AND CARBON-HYDROGEN BOND FORMING REACTIONS

1. A compound, comprising a transition metal complex having the formula ?-[M ((x,y)-L1)3?b?c((w,v)-L2)b((t,u)-L3)c]p+An?m,Z?p?m, wherein ? is ? or ?, wherein M is a transition metal, wherein p is an integer corresponding to the oxidation state of M, wherein each of x, y, w, v, t, and u independently comprises one of R and S, wherein each of L1 and L2 independently is a ligand comprising ethylene diamine, wherein L3 is EN(CH2)nNR1R2, wherein EN represents ethylene diamine, wherein n is from 2 to 4, and wherein R1 and R2 are independently H or alkyl groups, wherein c is from 1 to 3, wherein b is from 0 to 2, wherein An? comprises a lipophilic anion, wherein m is from 1 to 3, and wherein Z? comprises a second anion.
US Pat. No. 10,190,128

KITS COMPRISING PLUS-SENSE SINGLE STRANDED RNA VIRAL VECTORS AND METHODS FOR PRODUCING POLYPEPTIDES USING THE KITS

1. A kit comprisinga) a first plus-sense single stranded ribonucleic acid (RNA) viral vector, and
b) a second plus-sense single stranded RNA viral vector,
wherein
(i) the first plus-sense single-stranded viral vector and the second plus-sense single-stranded viral vector are derived from different plant viruses, and
(ii) the coat protein open reading frame (ORF) of the virus from which the first vector is derived is completely deleted in the first plus-sense single stranded RNA viral vector, and
(iii) the coat protein ORF of the virus from which the second vector is derived is completely deleted in the second plus-sense single stranded RNA viral vector, and
(iv) the first plus-sense single stranded RNA viral vector comprises a functional coat protein ORF of the virus from which the second plus-sense single-stranded viral vector is derived, and
(v) the second plus-sense single stranded RNA viral vector comprises a functional coat protein ORF of the virus from which the first plus- sense single-stranded viral vector is derived, and
(vi) the first plus-sense single-stranded viral vector and the second plus-sense single-stranded viral vector comprise an RNA replicon which is able to replicate in plant cells,
and wherein
the virus from which the first plus-sense single-stranded viral vector is derived is a Potexvirus, and
the virus from which the second plus-sense single-stranded viral vector is derived is a Tobamovirus.
US Pat. No. 10,188,591

METHOD OF ENHANCING HAIR GROWTH

ALLERGAN, INC., Irvine, ...

1. A method of growing eyebrow hair, comprising applying on at least one eyebrow an effective amount of a topical composition containing bimatoprost or a pharmaceutically-acceptable salt thereof.
US Pat. No. 10,190,129

INCREASING LEVELS OF NICOTINIC ALKALOIDS IN PLANTS

22nd Century Limited, LLC...

1. A method for increasing nicotine and yield in a Nicotiana plant, comprising:(a) crossing an increased nicotine Nicotiana plant that expresses heterologous NBB1 having the amino acid sequence set forth in SEQ ID NO: 2 and A622 having the amino acid sequence set forth in SEQ ID NO: 4 with a high yielding Nicotiana plant; and
(b) selecting progeny plant with increased nicotine and high yield, wherein the plant has an increased nicotine content and yield relative to a non-transformed control plant.
US Pat. No. 10,190,130

POLYSACCHARIDE SYNTHASES

The University of Melbour...

1. A method for decreasing the level of (1,3;1,4)-?-D-glucan produced by a plant or fungal cell, the method comprising decreasing the level and/or activity of a CslF-encoded (1,3;1,4)-?-D-glucan synthase in the cell, wherein the level and/or activity of the CslF-encoded (1,3;1,4)-?-D-glucan synthase is decreased by decreasing the expression of a CslF nucleic acid in the cell, and wherein decreasing the expression of a CslF nucleic acid in the cell results in a decrease of the level of (1,3;1,4)-?-D-glucan produced by the cell compared to a wild-type cell of the same taxon, and wherein the CslF nucleic acid comprises:(i) a nucleotide sequence set forth in SEQ ID NO: 1;
(ii) a nucleotide sequence encoding the amino acid sequence set forth in SEQ ID NO: 2; or
(iii) a nucleotide sequence encoding an amino acid sequence which is at least 90% identical to the amino acid sequence set forth in SEQ ID NO: 2.
US Pat. No. 10,189,874

DNA GRIDIRON COMPOSITIONS AND METHODS

Arizona Board of Regents ...

1. A composition, comprising:a plurality of immobile Holliday junction analogs wherein each junction comprises a 60° torsion angle linked together in a square frame having at least two layers in which the helices on opposite sides lie in the same plane, and wherein said plurality of immobile Holliday junction analogs are linked together with a central strand of single-stranded DNA within said square frame.
US Pat. No. 10,190,133

COMPOSITIONS AND METHODS FOR IMPROVING ABIOTIC STRESS TOLERANCE

China Agricultural Univer...

1. A recombinant nucleic acid, comprising:(a) the nucleotide sequence SEQ ID NO:1; or
(b) a nucleotide sequence that encodes a polypeptide comprising the amino acid sequence SEQ ID NO:28,
wherein each of the nucleotide sequences of (a) and (b) is operably linked to a heterologous promoter.
US Pat. No. 10,190,134

COMPOSITIONS AND METHODS FOR INSECTICIDAL CONTROL OF STINKBUGS

E I DU PONT DE NEMOURS AN...

1. An expression cassette, comprising a heterologous promoter operably linked to a polynucleotide encoding a double stranded RNA, wherein the double stranded RNA comprises the sense and antisense sequence of a nucleotide sequence selected from the group consisting of:(a) a nucleotide sequence comprising any one of SEQ ID NOS: 9, or 30-34;
(b) a nucleotide sequence comprising at least 95% sequence identity to any one of SEQ ID NOS: 9, or 30-34; and
(c) a nucleotide sequence comprising at least 23 consecutive nucleotides of any one of SEQ ID NOS: 9, or 30-34;
wherein said double stranded RNA has insecticidal activity against a Pentatomidae plant pest.
US Pat. No. 10,190,136

MOUSE MODEL OF ALPHA-ONE ANTITRYPSIN (AAT) DEFICIENCY

University of Massachuset...

1. A transgenic mouse whose genome comprises inactivating mutations in exon 2 of each of Serpina1a, Serpina1b, Serpina1c, Serpina1d, and Serpina1e genes, and which expresses no hepatic or circulatory Alpha-One Antitrypsin (AAT) protein.
US Pat. No. 10,189,881

MPS PEPTIDES AND USE THEREOF

The Regents of the Univer...

1. A method for one or more of: reducing, delaying, inhibiting or suppressing solid tumor cell growth or metastasis; promoting apoptosis; inhibiting cancer stem cell growth; inhibiting the PIP3 level in a tumor cell; or suppressing tumor cell mobility, the method comprising contacting the cell or tissue to be treated in vivo with an effective amount of an isolated polypeptide comprising no more than 51 amino acids, wherein the amino acid sequence comprises:XXXRYSYXXSYX (SEQ ID NO: 1) and optionally, wherein one or more serines has been substituted with a neutral or positively charged amino acid, wherein each X is a lysine and wherein each Y is a phenylalanine; or
XXXXXRYSYXXSYXLSGYSYXXNXX (SEQ ID NO: 5), and optionally a polypeptide comprising any contiguous 12 amino acid fragment thereof, and/or optionally, wherein one or more serines has been substituted with a neutral or positively charged amino acid and wherein each X is a lysine and wherein each Y is a phenylalanine.
US Pat. No. 10,190,139

METHOD FOR LACTIC ACID PRODUCTION USING MONASCUS STRAINS MODIFIED FOR LACTIC ACID PRODUCTION

1. A method of producing a composition comprising lactic acid, the method comprising:(i) providing a Monascus micro-organism that is tolerant to organic acid at a concentration of at least 50 g/L and a pH of less than 5.0 and has been genetically modified for increased production of a lactic acid by the introduction of an exogenous lactate dehydrogenase (LDH) gene; and
(ii) culturing the micro-organism in a medium having a pH less than 1.5 units above the pKa value of lactic acid in the presence of hexose, pentose, or a combination thereof, as the sole carbon source.
US Pat. No. 10,189,883

THERAPEUTIC USES OF MODIFIED FGF-21 POLYPEPTIDES

BRISTOL-MYERS SQUIBB COMP...

1. A method of decreasing or inhibiting fibrosis in a patient in need thereof, comprising administering to the patient an effective amount of a modified FGF-21 polypeptide comprising a polypeptide having at least 96% amino acid sequence identity to the amino acid sequence of SEQ ID NO: 202.
US Pat. No. 10,189,884

THIOAMIDE-MODIFIED PEPTIDES AND USES THEREOF

The Trustees of the Unive...

1. A peptide comprising the thioamide-modified amino acid sequence of SEQ ID NO:2, or a salt or solvate thereof,wherein residue 1 of SEQ ID NO:2 is the N-terminus residue of the peptide.
US Pat. No. 10,188,604

MEDICAL DEVICES INCLUDING MEDICAMENTS AND METHODS OF MAKING AND USING SAME

1. A method of treating or preventing a disease, disorder, or condition of the eye of a subject, comprising;a. providing a subject in need of treatment or prevention of said disease, disorder, or condition of the eye of said subject; and
b. providing at least one drug delivery contact lens, comprising:
i. a contact lens comprising a first surface and a second surface; and
ii. said contact lens further comprising at least one coating provided on at least a portion of said first surface, said second surface, or a combination thereof as opposed to within said contact lens;
a) said coating comprising at least one three dimensional structure;
b) said three dimensional structure comprising:
i) one or more drug reservoir layers; wherein said one or more drug reservoir layers comprise one or more drugs; and
ii) one or more barrier layers; wherein said one or more barrier layers modulafe the release of said one or more drugs from said drug delivery contact lens;
c) wherein said one or more drug reservoir layers, said one or more barrier layers, or a combination thereof, are oriented vertically, horizontally, or a combination thereof, relative to each other;
c. operably engaging said drug delivery contact lens with the eye of said subject;
wherein said one or more drugs are released from said drug delivery contact lens in an effective amount to treat or prevent a disease, disorder, or condition of the eye of said subject; and
d. wherein said subject is treated for or prevented from having or developing said disease, disorder, or condition of the eye of said subject; and
wherein said disease, disorder, or condition of the eye of said subject that is treated or prevented is an inflammation, an allergy, an infection, glaucoma, macular degeneration, a parasite, diabetes, dry eye, eye discomfort, or a combination thereof.
US Pat. No. 10,189,885

NON-HEMOLYTIC LLO FUSION PROTEINS AND METHODS OF UTILIZING SAME

The Trustees of the Unive...

1. An immunogenic composition comprising a recombinant protein comprising a listeriolysin O (LLO) protein comprising a mutation of amino acid residues on positions 2, 9 and 10 in the cholesterol-binding domain (CBD) of said LLO protein, said CBD is set forth in SEQ ID NO: 18.
US Pat. No. 10,188,605

NANOPARTICLES AND NANOPARTICLE COMPOSITIONS

Iowa State University Res...

1. An organic particle comprising a plurality of non-polymeric crosslinked amphiphiles;wherein the non-polymeric crosslinked amphiphile comprises one or more nonpolar (C6-C60)alkyl or (C6-C50)fluoroalkyl chains and one or more polar head groups;
the nonpolar chains are located on the exterior of the particle and the polar head groups are oriented toward the interior of the particle; and
the amphiphiles are covalently crosslinked to each other near the head groups through thioether groups comprising an ammonium group bonded thereto.
US Pat. No. 10,190,144

PRODUCTION OF DIRHAMNOSE-LIPID IN RECOMBINANT NONPATHOGENIC BACTERIUM PSEUDOMONAS CHLORORAPHIS

The United States of Amer...

1. A recombinant Pseudomonas chlororaphis that is derived from P. chlororaphis NRRL B-30761, said recombinant P. chlororaphis further comprises an expression vector, wherein said expression vector comprises a promoter operably linked to a heterologous polynucleotide encoding a heterologous Pseudomonas rhamnosyltransferase C, wherein rhlA and rhlB genes in said recombinant P. chlororaphis are operably linked to endogenous promoters.
US Pat. No. 10,190,402

CONTROLLING A BOTTOM-HOLE ASSEMBLY IN A WELLBORE

Halliburton Energy Servic...

1. A computer-implemented method of controlling a bottom hole assembly (BHA), the method comprising:determining, by a wellbore controller, a first candidate BHA control signal;
generating, by the wellbore controller, an input to a BHA control, the input comprising a perturbation signal superimposed on the first candidate BHA control signal;
controlling, by the wellbore controller, the BHA using the input to the BHA control;
determining, by the wellbore controller, a change in an objective value as a function of the perturbation signal, based on a received downhole sensor measurement; and
generating, by the wellbore controller and based on the change in the objective value, a second candidate BHA control signal.
US Pat. No. 10,189,890

VARIANTS OF TISSUE INHIBITOR OF METALLOPROTEINASE TYPE THREE (TIMP-3), COMPOSITIONS AND METHODS

Amgen Inc., Thousand Oak...

1. An isolated TIMP-3 mutein having a mature region that comprises the amino acid sequence of the mature region of TIMP-3 set forth in SEQ ID NO:2, wherein the mutein has(a) a mutation K45S, and
(b) a mutation F57N.