US Pat. No. 10,987,678

CENTRIFUGE AND CENTRIFUGE ROTOR FOR SUPPRESSING BUOYANCY

Eppendorf Himac Technolog...

1. A rotor for being accommodated in a rotor chamber of a centrifuge, the rotor comprising:a rotor body configured to hold a sample; and
a rotor cover that covers an opening portion of the rotor body,
wherein an inclined surface extending toward a radial outer side of an outer edge of an upper surface of the rotor cover and extending upward from the outer edge of the upper surface of the rotor cover is formed on the rotor body.

US Pat. No. 10,987,675

DEHYDRATION AND DISINTEGRATION APPARATUS AND SYSTEM

1. An apparatus for dehydrating and reducing a solid material into smaller particles comprising:an implosion chamber configured to receive the solid material from an inlet;
wherein the implosion chamber comprises a conical member and a flail propeller disposed below the conical member, wherein the flail propeller is configured to generate ultrasonic soundwaves that bounce off the implosion chamber walls;
wherein the flail propeller interacts with the solid matter to form a coarse smaller particle and a fine smaller particle;
a separating section comprising a cyclone exhaust head and a cyclone settling cone, wherein the cyclone exhaust head is operably connected to the implosion chamber via a separation column;
wherein the cyclone settling cone comprises an outlet configured to discharge the fine smaller particles exterior to the apparatus and the cyclone exhaust head is configured to reintroduce the coarse smaller particles received through the separation column back to the implosion chamber;
a mass circulator extending from a sidewall of the implosion chamber and comprising a curved cross section and a peripheral open surface to allow air and the smaller particles that have escaped from a bottom area of the implosion chamber to be repeatedly channeled towards the conical member while bouncing ultrasound at different angle;
wherein the mass circulator is disposed above the conical member and the flail propeller.

US Pat. No. 10,987,672

DUAL PISTON CENTRIFUGE TUBE

Emcyte Corp., Fort Myers...

14. A method for separating fluid biological product into constituent components using a centrifuge tube assembly, which assembly includes an elongate tubular receptacle having a lower end and a capped upper end; a first, common inlet and outlet port formed in the capped upper end of the receptacle for communicating with an interior chamber of the tubular receptacle; a second common inlet and outlet port formed through the lower end of the tubular receptacle and communicating with the chamber; a flexible, fluid-conducting pipe communicably connected to the first common inlet and outlet port for extending through the chamber of the tubular receptacle; a first liquid impermeable piston mounted within the tubular receptacle and sealably engaging an interior surface of a longitudinal sidewall of the tubular receptacle for moving longitudinally through the chamber of said receptacle, a fluid-conducting pipe being disposed through the first piston such that a distal end of said pipe communicates with said receptacle chamber below the first piston; and a second liquid impermeable piston mounted within the tubular receptacle and sealably engaging the interior surface of the longitudinal sidewall of the tubular receptacle for longitudinally sliding through the chamber of the tubular receptacle between the first piston and the lower end of the receptacle, said method comprising:introducing fluid biological product into the receptacle through the first common inlet and outlet port and fluid-conducting pipe below the first piston and above the second piston, such that the first piston is driven upwardly within said chamber as the fluid is introduced;
centrifuging the tubular receptacle a first time to separate the fluid into at least two constituent components;
aspirating a first constituent component from the receptacle chamber through the first common inlet and outlet port such that a suction is generated in the receptacle chamber, the first piston is drawn downwardly through the chamber of the tubular receptacle and a second constituent component is constrained in said chamber between the first and second pistons;
reintroducing the aspirated first constituent component into the chamber of the tubular receptacle through the second common inlet and outlet port such that the first and second pistons and the constrained second constituent component are driven upwardly through the tubular receptacle and the reintroduced first constituent component fills the tubular receptacle between the second piston and the lower end of the tubular receptacle;
centrifuging the tubular receptacle a second time to separate the first constituent components into third and forth constituent components constrained between said second piston and said lower end of the tubular receptacle; and
sequentially aspirating the third and forth constituent components through the second common inlet and outlet port.

US Pat. No. 10,987,671

RESERVOIR-BASED MANAGEMENT OF VOLUMETRIC FLOW RATE IN FLUIDIC SYSTEMS

Zaiput Flow Technologies ...

1. A fluidic system, comprising:a first fluidic separator;
a second fluidic separator;
a first fluidic pathway fluidically connected to an outlet of the first fluidic separator and an inlet of the second fluidic separator; and
a second fluidic pathway fluidically connected to an inlet of the first fluidic separator and an outlet of the second fluidic separator, the second fluidic pathway comprising a first segment, a second segment, a pump, and a reservoir;
wherein the reservoir is between the first segment and the second segment;
wherein the pump is between the second segment and the inlet of the first fluidic separator, and the pump is between the reservoir and the inlet of the first fluidic separator; and
wherein at least a portion of a wall of the reservoir is flexible.

US Pat. No. 10,987,670

ELECTRODE ARRAY FOR VORTEX-ASSISTED ELECTROPORATION

President and Fellows of ...

1. A device comprising:An array of microfluidic traps disposed along a set of microfluidic channels, the traps and channels having dimensions to create a fluid vortex within the traps to trap particles of interest; and
an electrode having sets of interdigitated electrically isolated fingers positioned in the traps to create an electric field across the traps such that the electric field causes electroporation of a molecules into the particle of interest wherein the electrodes include:
a positive conductive pad and a negative conductive pad disposed on opposite sides of the microfluidic channels;
a positive connective conductor and a negative connective conductor coupled the respective conductive pads;
sets of positive and negative finger connective conductors coupled to the interdigitated fingers, and;
sets of cross conductors disposed on opposite sides of the microfluidic channels to couple the positive connective conductor and positive finger connective conductors together and the negative connective conductor and negative finger connective conductors together, wherein the connective conductors are wider than the finger connective conductors and operate with the sets of cross conductors to minimize voltage variation across the traps.

US Pat. No. 10,987,668

TEST CARD WITH WELL SHELF

bioMerieux, Inc., Durham...

1. A test card comprising:a body comprising a first surface and a second surface opposite the first surface, the body defining at least one liquid supply conduit and at least one intake port, wherein the at least one intake port fluidically connects the at least one supply conduit with an exterior of the test card;
at least one well defining an opening extending from the first surface to the second surface and configured to receive a sample therein; wherein the at least one well comprises:
a wall bounding the opening and extending between the first surface and the second surface of the card;
a shelf defined by the wall, wherein a first portion of the wall extends from the shelf surface to the first surface and a second portion of the wall extends from the shelf surface to the second surface, and wherein the shelf protrudes from the first portion of the wall and connects the first portion of the wall to the second portion of the wall, and wherein the opening is narrower between the shelf and the second surface than between the shelf and the first surface, the shelf further defining a shelf surface substantially parallel to the first surface or the second surface; and
a supply conduit opening defined in the wall at a position above at least a portion of the shelf such that the supply conduit opening and the at least the portion of the shelf are aligned circumferentially relative to the at least one well, the supply conduit opening connecting the at least one liquid supply conduit with the at least one well such that the at least one well is fluidically connected to the at least one intake port.

US Pat. No. 10,987,666

METERING APPARATUS

Chemspeed Technologies AG...

1. An apparatus for metering a substance,having a metering head,
having a metering tool releasably attached to the metering head for taking up and dispensing a substance,
wherein the metering tool is configured as a cylindrical tubule having a punch slidably disposed therein, and forming a seal therewith, wherein the cylindrical tubule has a free edge at a lower end thereof adapted to be inserted within the substance, wherein the punch is longer than the tubule and projects out of the tubule at an upper end thereof and wherein the punch is slidable to project out of the tubule at both of the tubule ends simultaneously,
wherein the metering head is provided with a first gripping tool adapted to open and close for releasable clamping of the tubule and with a second gripping tool adapted to open and close for releasable clamping of the punch,
wherein the metering head is provided with a first raising and lowering device for raising and lowering the second gripping tool relative to the first gripping tool, thereby raising and lowering the punch in the tubule, and
wherein the apparatus comprises a rotation mechanism for rotating the metering tool about its longitudinal axis.

US Pat. No. 10,987,663

METHOD FOR PREPARING LAMINAR ZINC HYDROXIDE ORGANIC-INORGANIC NANOCOMPOSITES FOR USE IN THE REMOVAL AND DEGRADATION OF DYES FROM TEXTILE EFFLUENTS

UNIVERSIDAD DE CHILE, Sa...

1. A method for preparing laminar zinc hydroxide organic-inorganic nanocomposites for use in the removal and degradation of dyes from textile effluents and organic substances, comprising:a) dissolving in a vessel at least a zinc salt, oxide or hydroxide in distilled water until reaching a molar concentration of 0.1 to 5.0 M;
b) dissolving in a vessel at least a carbonate of alkali metals, alkaline-earth metals, other metals and metalloids in distilled water until reaching a molar concentration of 0.1 to 5.0 M;
c) forming a suspension by dropwise adding to a volume of the aqueous solution prepared in step (a), a volume of the aqueous carbonate solution prepared in step (b);
d) heating the suspension obtained in step (c), between 15-120° C. under constant stirring ranging from 5 to 10,000 rpm for a homogenization time between 0.1 min and 24 hours;
e) adjusting the reaction mixture of step (d) to a pH between 5 and 9.9 with an alkali solution with a molar concentration of 0.1 to 12.0 M;
f) homogenizing the suspension obtained in step (e) between 0.1 min and 24 hours at a temperature of 15-120° C. under constant stirring ranging between 5 to 10,000 rpm;
g) adding a volume of a molecular surfactant solution with a molar concentration of 0.1 to 12.0 M, where the surfactant comprises compounds having linear, branched or aromatic hydrocarbon chains with 2 or more carbon atoms, with hydrophilic groups;
h) homogenizing the resulting suspension in step (g) between 0.1 min and 24 hours at a temperature of 15-120° C. and under constant stirring ranging from 5 to 10,000 rpm;
i) maintaining the suspension resulting from step (h) at a temperature of 15-120° C. for a time between 0.1 min and 72 hours;
j) separating and washing solids obtained in step (i); and
k) drying the products obtained from step (j).

US Pat. No. 10,987,651

ENDOTOXIN ADSORBENT

National University Corpo...

1. An endotoxin adsorbent, comprising:a cellulose nanofiber having an amino group.

US Pat. No. 10,987,647

MULTISTAGE CATALYST INJECTION SYSTEM FOR AN OLEFIN POLYMERIZATION REACTOR

NOVA Chemicals (Internati...

1. An apparatus for the delivery of a multi-component olefin polymerization catalyst to a polymerization reactor, the apparatus comprising:a first catalyst component delivery conduit;
a second catalyst component delivery conduit which is disposed within the first catalyst component delivery conduit;
a first catalyst component mixing conduit;
a third catalyst component delivery conduit which is disposed within the first catalyst component mixing conduit;
a second catalyst component mixing conduit comprising an upstream section and a downstream section; and
a diluent delivery conduit;
the first and second catalyst component delivery conduits each being open ended and co-terminating at the first catalyst component mixing conduit, the first catalyst component mixing conduit and the third catalyst component delivery conduit each being open ended and co-terminating at the upstream section of the second catalyst component mixing conduit, the diluent delivery conduit being open ended and terminating at the downstream section of the second catalyst component mixing conduit, the downstream section of the second catalyst component mixing conduit being open ended and terminating within the polymerization reactor;
wherein, at least one first catalyst component soluble in a first solvent is delivered under pressure along with the first solvent to the first catalyst component mixing conduit via the first catalyst component delivery conduit, at least one second catalyst component soluble in a second solvent is delivered under pressure along with the second solvent to the first catalyst component mixing conduit via the second catalyst component delivery conduit, at least one third catalyst component soluble in a third solvent is delivered under pressure along with the third solvent to the upstream section of the second catalyst component mixing conduit via the third catalyst component delivery conduit, and at least one diluent is delivered under pressure to the downstream section of the second catalyst component mixing conduit via the diluent delivery conduit;
whereby, the at least one first catalyst component soluble in the first solvent comes into contact with the at least one second catalyst component soluble in the second solvent within the first catalyst component mixing conduit to form a catalyst support, the at least one third catalyst component soluble in the third solvent comes into contact with the catalyst support within the upstream section of the second catalyst component mixing conduit to form a pre-polymerization catalyst, and the at least one diluent comes into contact with the pre-polymerization catalyst within the downstream section of the second catalyst component mixing conduit before being expelled into the polymerization reactor.

US Pat. No. 10,987,646

DEHYDROGENATION OF ALKANES

1. A method for dehydrogenating of alkanes in a given temperature range T in a reactor system, said reactor system comprising a reactor unit arranged to accommodate a catalytic mixture, said catalytic mixture comprising catalyst particles in intimate contact with a ferromagnetic material, wherein said catalyst particles are arranged to catalyze the dehydrogenation of alkanes, and said ferromagnetic material is ferromagnetic at least at temperatures up to an upper limit of the given temperature range T, and an induction coil arranged to be powered by a power source supplying alternating current and positioned so as to generate an alternating magnetic field within the reactor unit upon energization by the power source, whereby the catalytic mixture is heated to a temperature within the given temperature range T by means of said alternating magnetic field, said method comprising the steps of:(i) generating an alternating magnetic field within the reactor unit upon energization by a power source supplying alternating current, said alternating magnetic field passing through the reactor unit, thereby heating catalytic mixture by induction of a magnetic flux in the material;
(ii) bringing a reactant stream comprising alkanes into contact with said catalyst particles;
(iii) heating said reactant stream within said reactor by the generated alternating magnetic field; and
(iv) letting the reactant stream react in order to provide a product stream to be outlet from the reactor,
wherein the catalytic mixture is selected from one of the following:
wherein the catalytic mixture comprises catalyst particles and ferromagnetic particles that are mixed and treated to provide bodies of catalytic mixture, said bodies having a predetermined ratio between catalyst and ferromagnetic particles,
wherein said catalytic mixture comprises bodies of catalyst particles mixed with bodies of ferromagnetic material, wherein the smallest outside dimension of the bodies is in the order of about 1-2 mm or larger, or
wherein said ferromagnetic material comprises one or more ferromagnetic macroscopic supports susceptible for induction heating, wherein said one or more ferromagnetic macroscopic supports are ferromagnetic at temperatures up to an upper limit of the given temperature range T, wherein said one or more ferromagnetic macroscopic supports is/are coated with an oxide and wherein the oxide is impregnated with catalyst particles.

US Pat. No. 10,987,641

MANUFACTURING METHOD AND MANUFACTURING APPARATUS THAT INCLUDES BLADES HAVING INCLINED SURFACES FOR MANUFACTURING A GRANULATED BODY

TOYOTA JIDOSHA KABUSHIKI ...

7. A manufacturing apparatus for a granulated body, the apparatus comprising:a dry agitator configured to agitate powder in a dry state; and
a wet agitator that is positioned below the dry agitator and configured to agitate the powder supplied from the dry agitator with a liquid component in the wet agitator by rotation of blades so as to form a granulated body, wherein:
the wet agitator includes an agitation chamber and the blades rotate inside the agitation chamber around a center axis that is parallel to a horizontal direction;
the blades include a first blade in a region on a first end portion side of the agitation chamber, and a second blade in a region on a second end portion side of the agitation chamber, the second end portion side being positioned across the agitation chamber from the first end portion side in a direction along the center axis, wherein the blades project in a radially outward direction from a rotating shaft disposed along the center axis;
a first surface of the first blade is a front side of the first blade when the first blade rotates around the center axis, the first surface includes a first inclined surface directed towards the first end portion side from the second end portion side, so that the first inclined surface is formed at a distal end of the first blade, and wherein an angle of the first inclined surface with respect to the radially outward direction is less than 90°; and
a second surface of the second blade is a front side of the second blade when the second blade rotates around the center axis, the second surface includes a second inclined surface directed towards the second end portion side from the first end portion side, so that the second inclined surface is formed at a distal end of the second blade, and wherein an angle of the second inclined surface with respect to the radially outward direction is less than 90°.

US Pat. No. 10,987,638

ASYMMETRIC POLYTETRAFLUOROETHYLENE COMPOSITE HAVING A MACRO-TEXTURED SURFACE AND METHOD FOR MAKING THE SAME

1. A composite article comprising:a first polytetrafluoroethylene (PTFE) membrane having a first surface and a second surface; and
a second PTFE membrane positioned on said second surface of said first membrane,
wherein said first PTFE membrane comprises a plurality of nodes interconnected by fibrils, each said node being formed of a solid mass of PTFE that is raised from the first surface, and
wherein each said solid mass of PTFE has a length greater than or equal to 1.5 mm when measured at any two points taken along the node when viewed with the naked eye.

US Pat. No. 10,987,636

FILTRATION SYSTEMS AND METHODS FOR MANUFACTURING BIOLOGICALLY-PRODUCED PRODUCTS

Massachusetts Institute o...

1. A filter probe, comprising:a fiber bundle comprising a plurality of hollow fibers,
wherein a center-to-center distance between any two hollow fibers within the fiber bundle at one or more points along a length of the fiber bundle is greater than or equal to 1.1 times a minimum diameter of the two hollow fibers,
wherein the filter probe has a diameter of about 25 mm or less and comprises 2500 or fewer fibers, and
wherein the filter probe is configured to be at least partially submerged in a liquid medium that is being filtered by the filter probe during operation.

US Pat. No. 10,987,633

ROTARY FILTER ARRANGEMENT HAVING A PLURALITY OF HOLLOW SHAFTS

GEA MECHANICAL EQUIPMENT ...

1. A filtration arrangement for a filtration device having a container, the filtration arrangement comprising:a plurality of hollow shafts rotatably mounted in a machine frame; and
a plurality of membrane filter disks disposed on the plurality of hollow shafts, wherein the plurality membrane filter disks are disposed axially spaced apart on each of the plurality of hollow shafts; and
deformable spacer sleeves, which axially mutually space apart the plurality of membrane filter disks on the plurality of hollow shafts, are disposed between part of or all of a neighboring membrane filter disks,
wherein the plurality of hollow shafts are coupled to at least one drive device;
wherein the plurality of hollow shafts are configured to discharge permeate from the container,
wherein an end of each of the plurality of hollow shafts on which the plurality of membrane filter disks are disposed is introducible into the container such that opposite ends of the hollow shafts project externally from the container,
wherein the plurality of hollow shafts are non-circular,
wherein an external cross-section of each of the plurality of hollow shafts defines a regular polygon, and
wherein the deformable spacer sleeves are pretensioned such that the deformable spacer sleeves deform such that an internal circumference of the deformable spacer sleeves, in a region of corners or of a largest external diameter of a respective one of the plurality of hollow shafts, are pushed onto an external circumference of the plurality of hollow shafts such that the axially spaced apart plurality of membrane filter disks are tightly clamped in a rotationally secured manner on the plurality of hollow shafts.

US Pat. No. 10,987,632

SPIRAL MEMBRANE ELEMENT

Nitto Denko Corporation

1. A spiral membrane element, comprising a plurality of membrane leaves in each of which a permeation-side flow-channel member is interposed between opposed separation membranes; a supply-side flow-channel member interposed between any two of the membrane leaves; a perforated central pipe on which the membrane leaves and the supply-side flow-channel member are wound; and sealing parts that prevent a supply-side flow-channel from being mixed with a permeation-side flow-channel;wherein the sealing parts comprise both-end sealing parts in which an adhesive is used to seal two-side end parts of each of the membrane leaves on both sides of the leaf in an axial direction of the leaf, and
the both-end sealing parts have a thickness of 390 to 540 m;
wherein the permeation-side flow-channel member is a tricot knit having a density of 0.4 to 0.8 g/cm3;
wherein the tricot knit comprises a plurality of ribs each made to comprise loops repeated linearly in a longitudinal direction, and a plurality of grooves present between these ribs, and
the permeation-side flow-channel member has a membrane support index of 60 or more, the index being calculated in accordance with the following expression:
number(wale) of the grooves per 25-mm×{rib width(mm)/groove width(mm)}.

US Pat. No. 10,987,631

FILTER CASSETTE ARTICLE, AND FILTER COMPRISING SAME

SMARTFLOW TECHNOLOGIES, I...

1. A filtration cassette comprising at least one assembly, wherein the at least one assembly comprises:a multilaminate array of sheet members of generally rectangular and generally planar shape, each sheet of the array having a first end, a second end longitudinally opposite the first end, and a thickness, wherein the sheet members comprise in sequence in said array, a first retentate sheet, (a permeate pack and a second retentate sheet)n, wherein n=1, 2, 3, 4, 5, 6, 7, 8, 9, 10, or more, wherein the permeate pack comprises a first filter sheet, a permeate sheet, and a second filter sheet, wherein each sheet in each permeate pack has at least one fluid opening at the first end thereof and at least one fluid opening at the second end thereof, wherein corresponding fluid openings at the first end of each sheet in each permeate pack are in register with one another and corresponding fluid openings at the second end of each sheet in each permeate pack are in register with one another, wherein the first and second retentate sheets have at least one channel opening therein, each channel opening extending longitudinally between a first channel entrance positioned proximate to fluid openings at the first end of the permeate pack and a second channel entrance positioned proximate to fluid openings at the second end of the permeate pack in the array, and wherein the at least one channel opening is open through the entire thickness of the first and second retentate sheets to permit a fluid to contact adjacent filter sheets, and wherein the first and second retentate sheets are bonded to adjacent filter sheets about peripheral end and side portions thereof; and
two assembly end plates sandwiching the multilaminate array of sheets, each end plate having a first end and a second end corresponding to that of the multilaminate array of sheets, wherein the two assembly end plates comprise at least one fluid opening at the first end thereof and at least one fluid opening at the second end thereof, wherein fluid openings of the end plates are in register with corresponding fluid openings of the permeate pack,
wherein the at least one assembly further comprises at least one permeate passage opening at longitudinal side margin portions of the sheet members of the assembly, wherein the filtration cassette further comprises
a cap positioned on at least a portion of at least one fluid opening of the permeate pack, wherein the cap is positioned proximate to channel openings entrances of the first and second retentate sheets, and wherein the cap has a general U-shape and transverses the permeate pack through the fluid opening and at least partially overlaps a first side of the first filter sheet and at least partially overlaps a second side of the second filter sheet, with the permeate sheet positioned therebetween.

US Pat. No. 10,987,629

METHOD FOR REMOVING BIOPOLYMER AGGREGATES AND VIRUSES FROM A FLUID

Sartorius Stedim Biotech ...

1. A method for removing biopolymer aggregates and parvoviruses from a fluid, comprising the steps of:(a) filtering the fluid containing the biopolymer aggregates and parvoviruses through a porous, polyamide shaped body consisting of nylon-6, the porous, polyamide shaped body having internal and external surface regions and being configured so that all of the internal and external surfaces regions have the same chemical properties, the filtering of the fluid containing the biopolymer aggregates and parvoviruses through the porous, polyamide shaped body causing the biopolymer aggregates to be selectively depleted from the fluid by adsorption, whereas the parvoviruses permeate through the shaped body in a biopolymer aggregate-depleted fluid; and
(b) filtering the biopolymer aggregate-depleted fluid from step (a) through at least one parvovirus-retentive membrane having a molecular weight cut-off of from 100 to 1000 kD, wherein the content of parvoviruses in the fluid that has passed through the at least one parvovirus-retentive membrane is reduced by at least 99.9% with respect to the content of parvoviruses prior to carrying out step (a); wherein:
the biopolymer aggregates are selected from the group of the dimers, trimers or multimers of peptides, proteins, nucleic acids or mixtures thereof;
the fluid comprises a human blood plasma product, a protein solution obtained from a cell culture, a protein solution obtained from extraction of plant products, or a protein solution obtained from microorganisms;
the pH of the fluid during steps (a) and (b) is 9;
the porous, polyamide shaped body comprises a microporous membrane; and
the membrane used in step (b) comprises a material selected from the group consisting of polyethersulfone and polysulfone.

US Pat. No. 10,987,628

WATER CONTROL IN DIELECTRIC FLUID LAYERS

Palo Alto Research Center...

1. A system for regulating water concentration, the system comprising:a dielectric fluid;
at least a pair of electrodes configured to apply an electric field across the dielectric fluid, thereby causing charge carriers and water included in the charge carriers to move toward a respective electrode; and
a pair of water-traps separated from each other by the dielectric fluid, wherein each water-trap is positioned adjacent to a corresponding electrode and comprises a water absorbing material capable of trapping water, thereby reducing the concentration of water in the dielectric fluid.

US Pat. No. 10,987,625

STERILIZATION EXHAUST GAS TREATING SYSTEM AND METHOD FOR TREATING ETHYLENE OXIDE-CONTAINING STERILIZATION EXHAUST GAS BY USING THE SAME

Chio Kang Medical, Inc., ...

1. A sterilization exhaust gas treatment system, comprising:a gas liquefaction recovery system;
a pressure swing adsorption recovery system;
a reaction system;
a temperature swing adsorption recovery system;
a hydration system;
a recovery and storage system; and
a wastewater treatment system;
wherein the gas liquefaction recovery system, the pressure swing adsorption recovery system, the reaction system, the temperature swing adsorption recovery system, and the hydration system are fluidly connected in sequence through one or more first connecting pipes;
wherein the gas liquefaction recovery system, the pressure swing adsorption recovery system, and the temperature swing adsorption recovery system are each fluidly connected to the recovery and storage system through one or more second connecting pipes; and
wherein the hydration system is fluidly connected to the wastewater treatment system through one or more wastewater pipes.

US Pat. No. 10,987,623

SORBENTS FOR THE OXIDATION AND REMOVAL OF MERCURY

Midwest Energy Emission C...

25. A method of separating mercury from a mercury-containing gas, the method comprising:combusting in a combustion chamber
coal fed to the combustion chamber, and
a halogen or halide promoter, a promoter precursor that transforms into the promoter, or combination thereof, added to the coal, added to the combustion chamber, or a combination thereof;
to provide the mercury-containing gas, wherein
the mercury-containing gas comprises the halogen or halide promoter,
the halogen or halide promoter and promoter precursor comprises chlorine (Cl2), chloride (Cl?), bromine (Br2), bromide (Br?), iodine (I2), iodide (I?), or a combination thereof, and
the Cl2, Cl?, Br2, Br?, I2, I31 , or the combination thereof added to the combustion chamber, added to the coal, or a combination thereof is about 1 to about 3000 ppmw per weight of the coal fed to the combustion chamber, or
the Cl2, Cl?, Br2, Br?, I2, I?, or the combination thereof added to the combustion chamber, added to the coal, or a combination thereof is about 0.001 wt % to about 30 wt % of a sorbent material added to the mercury-containing gas, or
a combination thereof
adding the sorbent material into the mercury-containing gas downstream of the combustion chamber such that the sorbent material contacts the halogen or halide promoter in the mercury-containing gas;
contacting mercury in the mercury-containing gas with the sorbent, to form a mercury/sorbent composition; and
separating the mercury/sorbent composition from the mercury-containing gas.

US Pat. No. 10,987,621

SYSTEM AND METHOD FOR REMOVING HARMFUL GAS IN DISCHARGED CLEANING SOLUTION OF EXHAUST GAS TREATMENT APPARATUS

Panasia Co., Ltd., Busan...

1. A system for removing noxious gas from cleaning liquid discharged from an exhaust gas treatment apparatus, comprising:an exhaust gas treatment apparatus configured to receive exhaust gas generated by the combustion and flowing thereinto, remove noxious gas from the exhaust gas by spraying cleaning liquid to the exhaust gas, and discharge the sprayed cleaning liquid;
a noxious gas removal unit connected to the exhaust gas treatment apparatus and configured to remove the noxious gas remaining in a gaseous state in the cleaning liquid discharged from the exhaust gas treatment apparatus and discharge the cleaning liquid from which the noxious gas in the gaseous state has been removed;
a level measuring unit configured to measure a level of the cleaning liquid in the noxious gas removal unit; and
a flow rate regulator configured to adjust a discharge rate of the cleaning liquid in the noxious gas removal unit on the basis of a result of measurement by the level measuring unit.

US Pat. No. 10,987,620

ABSORPTION ROTOR, ROTOR ELEMENT, METHOD OF MANUFACTURING ABSORPTION ROTOR, AND METHOD OF MANUFACTURING ROTOR ELEMENT

NICHIAS Corporation, Tok...

1. An absorption rotor provided in a flow passage of a gas containing a substance to be absorbed, the absorption rotor through which the gas passes while the absorption rotor is rotated about a rotation axis, comprising:plural plate members extending in a radial manner from a circumference of the rotation axis;
a tubular outer edge member coupling end portions of the plural plate members;
an absorption member accommodated in a space which is surrounded by the plural plate members and the tubular outer edge member, the absorption member that absorbs the substance to be absorbed when the gas passes through; and
a drop-off prevention member respectively fixed to one plate member of the plural plate members and the absorption member, the drop-off prevention member that prevents the absorption member from dropping off the plate member,
wherein
the drop-off prevention member is arranged between the absorption member and the plate member, and between a surface from which the gas flows into the absorption member and a surface from which the gas flows out of the absorption member,
the drop-off prevention member has an embedded portion embedded in the absorption member, and an exposed portion exposed from the absorption member,
the embedded portion is fixed to the absorption member, and the exposed portion is fixed to the plate member,
the plate member has a holding portion that holds an inner end portion of the exposed portion, the inner end portion being an end portion of the exposed portion of the drop-off prevention member on the side close to the rotation axis, and
the holding portion is provided on a surface of the plate member that is adjacent to the rotation axis, and protrudes from the surface of the plate member.

US Pat. No. 10,987,616

TUMBLER SYSTEMS AND METHODS

Gala Industies, Inc., Ea...

1. A conditioning unit for conditioning materials, the conditioning unit comprising:a drum comprising:
an inlet end;
an outlet end opposite the inlet end;
a plurality of frame members extending from the inlet end to the outlet end and defining a plurality of sides, each of the sides housing one or more screens, and one or more of the sides having an opening proximate the outlet end of the drum; and
one or more annular rings each bordering a side of the opening of the one or more sides proximate the outlet end of the drum;
an inlet chute in fluid communication with the inlet end of the drum, the inlet chute being configured to direct a flow of materials into the drum; and
an outlet chute in fluid communication with the opening of the one or more sides proximate the outlet end of the drum, the outlet chute having one or more ridges configured to at least partially overlap with the one or more annular rings of the drum to contain a flow of conditioned materials exiting the drum within the outlet chute.

US Pat. No. 10,987,615

MANIFOLD ASSEMBLY AND METHOD OF USE

PALL CORPORATION, Port W...

1. A manifold assembly for use with a filter capsule having a first fitting and a second fitting, the manifold assembly comprising:(a) an upper adjustable frame arrangement comprising a block comprising a through hole for receiving the first fitting, a first side wall, a second side wall, a front wall, and a rear wall, the rear wall including a locking pin opening and a cavity for receiving a linear guide comprising a grooved plate, wherein the linear guide is mounted to the block and is arranged to guide the upper adjustable frame arrangement vertically between a first position and a second position; a slidable handle arranged on the first side wall; a slot in the first side wall; a slidable locking pin arranged in the block, the slidable locking pin having an end, wherein the slidable locking pin can be extended from the block through the locking pin opening upon slidably moving the handle horizontally, wherein the slidable handle is connected to the slidable locking pin by at least one retainer passing through the slot in the first side wall, wherein the slidable handle can move the slidable locking pin to slide the locking pin end into a first opening to lock the upper adjustable frame arrangement in the first position, and to slide the locking pin end into a second opening to lock the upper adjustable frame arrangement in the second position, wherein the upper adjustable frame arrangement is movable along the linear guide between the first and the second positions when the locking pin end is not in the first opening or the second opening;
(b) a lower frame arrangement comprising a through hole for receiving the second fitting; and,
(c) a manifold frame connected to the upper adjustable frame arrangement and connected the lower frame arrangement, the manifold frame including the first opening and the second opening.

US Pat. No. 10,987,614

RETROFITTABLE NO FILTER NO RUN FILTRATION SYSTEM

CUMMINS FILTRATION IP, IN...

18. A method of operating a fluid filtration assembly, comprising:coupling a no filter no run attachment to a pump inlet, the no filter no run attachment comprising:
a shell defining a fluid passage from an upstream fluid aperture at a first end for fluid receiving communication with a filtration cartridge to a downstream fluid aperture at a corresponding second end, the shell sized and shaped for coupling to the pump inlet such that the pump inlet is annularly disposed about an outer circumference of the shell,
the shell comprising an annular flange disposed about the outer circumference of the shell and surrounding the downstream fluid aperture of the shell, the annular flange structured for engagement to the pump inlet,
the shell further defining a pin aperture through which a pin of the filtration cartridge may be disposed;
a divider segmenting the fluid passage into an upstream portion that comprises the upstream fluid aperture and the pin aperture and a downstream portion that comprises the downstream fluid aperture, and defining an internal aperture on the divider that allows fluid communication between the upstream portion and the downstream portion; and
a ball disposed in the upstream portion in fluid flow receiving communication with the upstream fluid aperture, and sized to have a greater diameter than the internal aperture such that an engagement of the ball to the divider within the internal aperture blocks fluid communication between the upstream portion and the downstream portion.

US Pat. No. 10,987,613

FILTER SYSTEM WITH CENTRAL ELEMENT AND STRAINER FILTER

1. A filter housing for a filter system, the filter housing having a housing axis, the filter housing comprising: a housing top part having: an annular receptacle formed as an annular projection on an inner surface of the housing top part and projecting in a direction of the housing axis into an interior of the filter housing, the annular receptacle comprising at least one electrical connecting element arranged in an interior of the annular receptacle; an outlet socket arranged on the housing top part and fluidically connected to the interior of the annular receptacle through the top housing part, the outlet socket fluidically connected to discharge the fluid from the interior of the annular receptacle; an inlet socket arranged on the housing top part and configured to supply fluid to be filtered into the interior of the filter housing; andan axially elongated central element fixedly mounted onto the top housing part and extending along the housing axis in the interior of the filter housing, the axially elongated central element of the housing top part having an annular strainer filter fixed onto the axially elongated central element, the annular strainer filter spaced apart radially outwardly away from and surrounding a radial outer side of the axially elongated central element of the housing top part, the spacing forming an annular fluid outflow channel arranged between and bounded by the radial outer side of the axially elongated central element and a radially inner side of the annular strainer filter;
a housing bottom part arranged along the housing axis of the filter housing and connected to the housing top part, wherein an axial direction, as used herein, is a direction of the housing axis;
wherein the annular strainer filter is sealably connected onto the annular receptacle, fluidically connecting the annular fluid outflow channel of the axially elongated central element to the interior of the annular receptacle and to the outlet socket to discharge the fluid from the annular fluid outflow channel;
wherein a filter element is detachably connected to the axially elongated central element;
wherein a heater is integrated into the axially elongated central element of the housing top part, the heater received into the interior of the filter element.

US Pat. No. 10,987,611

MULTI-PURPOSE GAS SEPARATOR UNIT AND ASSOCIATED METHODS

William Jacob Management,...

1. A multi-purpose gas separator apparatus, comprising:a vessel defining an interior, the vessel having a barrier separating the interior into first and second chambers;
a first weir plate dividing the first chamber into a first waterside and a first condensate-side;
a first inlet of the vessel communicating with the first chamber;
a plurality of first outlets of the vessel communicating with the first chamber, the first outlets including a first gas outlet, a first water outlet in communication with the first waterside, and a first condensate outlet in communication with the first condensate-side;
a second weir plate dividing the second chamber into a second waterside and a second condensate-side;
a second inlet of the vessel communicating with the second chamber; and
a plurality of second outlets of the vessel communicating with the second chamber, the second outlets including a second gas outlet, a second water outlet in communication with the second waterside, and a second condensate outlet in communication with the second condensate-side.

US Pat. No. 10,987,610

ATMOSPHERIC WATER GENERATION HAVING MULTI-STAGE PATHOGENS NEUTRALIZING ELEMENTS

1. A system for atmospheric water generation, the system comprising:a first subsystem configured to be located in an outdoor location, the first subsystem including,
a first housing,
a cooling element configured to receive outdoor air at ambient pressure,
a water collector disposed near the cooling element that is configured to collect a condensed water; and
a second subsystem configured to be located in an indoor location, the second subsystem coupled to the first subsystem, the second subsystem including,
a second housing,
a pathogen neutralizing module including a membrane filter having a pore size of 0.1 microns to 10 microns, wherein the pathogen neutralizing module configured to receive the condensed water at 12 to 14 pounds per square inch (psi) of pressure above ambient pressure and remove pathogens from the condensed water;
a water storage bladder coupled to the pathogen neutralizing module, the water storage bladder being void of air, configured to receive the condensed water, and configured to be pressurized to 12 to 14 psi above ambient pressure by a stored energy device, and
a tap coupled to the water storage bladder.

US Pat. No. 10,987,607

SHORT DISTILLATION HEAD WITH INTEGRATED COOLING SPIRAL

1. A distillation apparatus comprising:a lower end entry portal;
a vertically extending passageway from said lower end entry portal to, or into, a portion of an interior space of a fraction collector which is vertically above a side exit portal of said fraction collector; and
a cooling spiral surrounded by at least a part of a vertical extent of said fraction collector.

US Pat. No. 10,987,605

CHILD DEVELOPMENT TOY

Lovevery, Inc., Boise, I...

1. A child development toy comprising:a box defining an interior compartment and an aperture extending into the interior compartment through a side of the box; and
a set of flexible sheets, each sheet having a corner and defining a bounded slit surrounded by material of the sheet and configured to receive the corner of another sheet inserted therethrough, such that the set of sheets is configurable as a chain of sheets, each two adjacent sheets of the chain being releasably connected by a connection formed by a corner of one of the two adjacent sheets inserted into the slit of the other of the two adjacent sheets, such that with the chain of sheets disposed within the interior compartment of the box with a last sheet of the chain extending through the aperture, a corner of a next-to-last sheet of the chain may be pulled through the aperture, followed by separation of the last sheet of the chain from the next-to-last sheet of the chain, by pulling on the last sheet of the chain.

US Pat. No. 10,987,604

TRANSFORMABLE TOY

Spin Master Ltd., Toront...

1. A game comprising:an external releaser target;
an expandable traveling toy configured to be selectively placed into a compact-shape position and a character-shape position,
said expandable traveling toy comprising a main body section and a plurality of auxiliary components each rotatably attached to the main body section,
wherein the expandable traveling toy is configured to roll along a surface in the compact-shape position,
wherein the external releaser target is physically separable from the expandable traveling toy;
a magnetically-responsive releasable latch secured to the expandable traveling toy,
said magnetically-responsive releasable latch directly attaching to at least one first auxiliary component of the plurality of auxiliary components and latching the at least one first auxiliary component to the main body section when the expandable traveling toy is in the compact shape position;
at least one second auxiliary component of the plurality of auxiliary components directly contacting a portion of the at least one first auxiliary component and held by the portion of the at least one first auxiliary component when the expandable traveling toy is in the compact shape position,
wherein the external releaser target and the expandable traveling toy are configured to be attracted to each other in response to a magnetically-attractive force,
wherein, in response to the external releaser target and the expandable traveling toy being attracted to each other in response to the magnetically-attractive force, the magnetically-responsive releasable latch is actuated,
wherein, upon actuation of the magnetically-responsive releasable latch, the expandable traveling toy is placed into the character-shape position,
wherein when in the character-shape position, each of the plurality of auxiliary components remains attached to the main body section and is released outwardly relative to the main body section; and
a single spring imparting force on the at least one first auxiliary component and the at least one second auxiliary component to place the expandable traveling toy into the character-shaped position,
wherein release of the plurality of auxiliary components into the character-shape position prevents the expandable traveling toy from rolling relative to the surface.

US Pat. No. 10,987,603

MALLEABLE BED COVER WITH ACCESSORIES

1. A decorative cover for a bed frame, the bed frame having a head board, a foot board, a first side rail, and a second side rail, the decorative cover comprising:a removable head board cushion configured to cover a top and sides of the head board;
a removable foot board cushion configured to cover a top and sides of the foot board;
a stretchable cover comprising a head board portion, a foot board portion, a first side portion, a second side portion, a top portion, and a bottom portion, and;
a flexible rod configured to lift the top portion of the flexible cover;
wherein the head board portion includes at least one first storage compartment and is configured to be pulled over the head board when the removable head board cushion is covering the head board;
wherein the foot board portion includes at least one second storage compartment and is configured to be pulled over the foot board when the removable foot board cushion is covering the foot board;
wherein the first side portion includes a first side clip configured to clip onto the first side rail, and at least one first zipper configured to permit access to a trundle bed or under bed storage;
wherein the second side portion includes a second side clip configured to clip onto the second side rail, and at least one second zipper configured to permit access to a trundle bed or under bed storage;
wherein the top portion includes at least one third zipper configured to permit removal or attachment of at least one guard rail, and a removable mattress cover having a hollow cylinder;
wherein the bottom portion includes at least one opening configured to allow removal or replacement of the head board cushion and the foot board cushion there through; and
wherein the flexible rod is configured to connect with the first side clip, the second side clip, and the hollow cylinder.

US Pat. No. 10,987,602

WEIGHT DEVICE FOR MODEL CAR

1. A weight device for a model car, the weight device being attached to an outer periphery of a wheel of the model car, the weight device comprising:an annular case extended along a circumferential direction of the wheel, the annular case having an annular internal space; and
one or more weight members arranged in the annular internal space, wherein
the weight members are configured to be relatively movable in the circumferential direction with respect to the annular case when the annular case is rotated in the circumferential direction,
the annular case has:
an inner cylindrical body;
an outer cylindrical body arranged outside the inner cylindrical body to form the annular internal space between the inner cylindrical body and the outer cylindrical body;
annular side plates that close both ends of the annular internal space in a center axis direction of the annular case; and
an annular plate that is arranged between both of the annular side plates in parallel with both of the annular side plates and extended in the circumferential direction so that the annular plate divides the annular internal space into a first housing space and a second housing space in the center axis direction,
the one or more weight members are arranged in at least one of the first housing space and the second housing space,
the annular plate is protruded from an outer peripheral surface of the inner cylindrical body toward the outer cylindrical body,
a clearance which is smaller than a diameter of the weight members is formed between an outer end of the annular plate and the outer cylindrical body,
a lubricating oil is stored in the annular case so that an oil surface is located below a center axis of the annular case in a stationary state where the annular case is vertically placed,
the lubricating oil can be transferred between the first housing space and the second housing space through the clearance,
the weight members have a spherical shape,
the weight members are arranged below the center axis of the annular case in the stationary state where the annular case is vertically placed,
the weight members are configured to be relatively moved in the circumferential direction with respect to the annular case so as to stay below the center axis of the annular case, and
the annular case is attached to the outer periphery of the wheel so that the wheel is idly rotatable with respect to the annular case.

US Pat. No. 10,987,601

ASSEMBLY WITH INNER OBJECT IN HOUSING THAT BREAKS OUT OF HOUSING

Spin Master Ltd., Toront...

1. A toy assembly, comprising:a housing having an outside surface, wherein the housing defines an interior space;
an inner object in the interior space of the housing;
a tether connected to the housing; and
a breakout motor that is operatively connected to the inner object that is inside the housing, and wherein an end of the tether is connected to the inner object, thereby operatively connecting the breakout motor to the tether, such that operation of the breakout motor rotates the inner object, which pulls the tether, which in turn pulls a portion of the outside surface of the housing through into the interior space of the housing, thereby ripping a hole in the housing,
wherein the inner object is in the form of a toy character and is sized to be removable from the housing through the hole.

US Pat. No. 10,987,600

CLOTHING FOR A TWO-DIMENSIONAL DOLL

1. Two-dimensional clothing for a flat doll having shoulders, the two-dimensional clothing comprising:a first side of a piece of paper and a second side of the piece of paper;
on the first side of the piece of paper, a depiction of a front side of clothing and a depiction of a back side of clothing;
a fold line at a line of symmetry between the depiction of the front side and the depiction of the back side of the two-dimensional clothing;
at least one shoulder strap with a front side portion and a back side portion separated by the fold line;
a folded area formed on the at least one shoulder strap, the folded area formed by two additional folds that intersect at the fold line on a side adjacent a portal of the two-dimensional clothing and extend outwardly away from the fold line to an opposite side of the at least one shoulder strap;
wherein one of glue and tape is placed on the second side of the piece of paper, covering the fold line and the folded area such that the two additional folds of the folded area remains folded;
wherein the portal extends from said line of symmetry, away from said line of symmetry in either direction; and,
wherein the two-dimensional clothing is adapted for placement on the shoulders of said flat doll through use of the at least one shoulder strap extending from the front side of the two-dimensional clothing to the back side of the two-dimensional clothing.

US Pat. No. 10,987,596

SPECTATOR AUDIO ANALYSIS IN ONLINE GAMING ENVIRONMENTS

Amazon Technologies, Inc....

1. A system, comprising:one or more computing devices configured to implement a game spectating system configured to:
receive spectator audio input for a plurality of spectators associated with a plurality of spectator devices receiving a video broadcasted from a broadcaster device via the game spectating system;
analyze the spectator audio input to generate audio analysis information, wherein the audio analysis information indicates that the plurality of spectators are respectively associated with a particular group of a plurality of groups; and
send, to the game spectating system, one or more indications of the group as metadata for the plurality of spectators to affect the video.

US Pat. No. 10,987,595

GAME PUBLISHER AND BROADCASTER INTEGRATION PLATFORM

Amazon Technologies, Inc....

1. A system comprising:one or more computing nodes comprising memory that at least:
receive information indicative of a video stream of a first gameplay of a videogame operated on a first client device, the first gameplay originating from the first client device, the video stream sent from the first client device to a second client device;
identify a first content of the first gameplay included in the video stream sent to the second client device, wherein identifying the first content comprises determining that the first content is included in a first frame of a plurality of frames that are rendered by the videogame operated on the first client device, and wherein the identifying the first content further comprises providing an indication that the first content is included in the first frame;
in response to the identifying the first content, send the second client device information indicative of the first content being available to incorporate into a second gameplay of the second client device;
receive information indicative of making the first content available to the second gameplay; and
update content accessible to the second client device to enable use of the first content in the second gameplay of the second client device.

US Pat. No. 10,987,594

SYSTEMS AND METHODS TO ELICIT PHYSICAL ACTIVITY IN USERS ACTING AS CARETAKERS OF PHYSICAL OBJECTS

Disney Enterprises, Inc.,...

1. A system configured to elicit physical activity in users acting as caretakers of physical objects, the system comprising:non-transitory electronic storage storing caretaking information, the caretaking information defining a set of caretaking criteria of a physical object, individual caretaking criteria comprising one or more caretaking requirements of the physical object to be satisfied based on physical activity of a user, the set of caretaking criteria including a first criterion;
one or more physical processors configured by machine-readable instructions to:
obtain a fitness plan for the user, the fitness plan specifying various physical fitness goals of the user at specified points in time;
determine the caretaking information based on the fitness plan so that the individual caretaking criteria in the set of caretaking criteria of the physical object specify individual caretaking requirements of the physical object which are to be satisfied based on individual values of individual activity attributes corresponding to the various physical fitness goals at the specified points in time;
effectuate presentation of the individual caretaking criteria included in the set of caretaking criteria of the physical object to elicit the physical activity of the user, including effectuating presentation of the first criterion;
obtain output signals from one or more sensors coupled to the physical object, the output signals conveying activity information, the activity information defining one or more values of one or more activity attributes of the physical activity of the user, such that the activity information defines a first value of a first activity attribute and a second value of the first activity attribute;
determine whether the individual caretaking criteria are satisfied based on the one or more values of the one or more activity attributes, including determining whether the first criterion is satisfied based on the first value or the second value;
responsive to the individual caretaking criteria being satisfied based on the one or more values of the one or more activity attributes, effectuate presentation of a satisfaction notification via the one or more output devices, such that responsive to the first criterion being satisfied based on the second value, effectuate presentation of a first satisfaction notification;
responsive to the individual caretaking criteria not being satisfied based on the one or more values of the one or more activity attributes, effectuate presentation of a nonsatisfaction notification via the one or more output devices;
responsive to the individual caretaking criteria being satisfied based on the one or more values of the one or more activity attributes, obtain additional previously unavailable caretaking criteria for the set of caretaking criteria such that the additional previously unavailable caretaking criteria are unlocked based on satisfaction of prior ones of the individual caretaking criteria, wherein the additional previously unavailable caretaking criteria are to be satisfied based on the physical activity yet to be undertaken by the user as the user progresses to the physical fitness goals; and
wherein the one or more activity attributes include a plurality of activity attributes, the plurality of activity attributes including:
a running attribute, wherein a value of the running attribute specifies one or more of a speed at which the user ran, a distance the user ran, a starting location of running, or an ending location of running;
a walking attribute, wherein a value of the walking attribute specifies one or more of a speed at which the user walked, a distance the user walked, a starting location of walking, or an ending location of walking;
a lifting attribute, wherein a value of the lifting attribute specifies one or more of an elevation of the physical object, a change in the elevation of the physical object, or a quantity of occurrences of achieving a particular elevation of the physical object;
a quietness attribute, wherein a value of the quietness attribute specifies one or both of a sound level measurement of an ambient environment of the physical object or a duration over which a given sound level measurement was recorded;
a stillness attribute, wherein a value of the stillness attribute specifies one or both of an amount of movement or a duration over which the amount of movement is present; and
a breathing attribute, wherein a value of the breathing attribute specifies one or both of an amount of air pressure incident on the physical object or a duration over which the amount of air pressure is incident on the physical object.

US Pat. No. 10,987,593

DYNAMIC INTERFACES FOR LAUNCHING DIRECT GAMEPLAY

SONY INTERACTIVE ENTERTAI...

1. A method for direct activity launch within interactive content, the method comprising:storing data in memory of a platform server regarding a plurality of interactive content titles, each interactive content title including a virtual environment and associated with one or more templates each linking to a specified starting point of an activity within the virtual environment;
establishing a session between a user device and the platform server, wherein a set of templates is provided to the user device during the session;
providing an interface display to the user device, the interface display including a set of activities corresponding to the set of templates;
receiving a selection of one of the set of activities in the interface display, the selection received from the user device;
identifying which of the set of templates and which of the plurality of interactive content titles are associated with the selected activity; and
launching the virtual environment of the identified interactive content title at the specified starting point, specified by the identified template associated with the selected activity, wherein launching the virtual environment at the specified starting point includes skipping a portion of the identified interactive content title.

US Pat. No. 10,987,589

SYSTEMS AND METHODS FOR DETERMINING GAME LEVEL ATTRIBUTES BASED ON PLAYER SKILL LEVEL PRIOR TO GAME PLAY IN THE LEVEL

Zynga Inc., San Francisc...

1. A computer-implemented method, comprising:calculating a player skill level for a player of a computer-implemented game based at least on a plurality of game moves in a first game level completed by the player;
prior to game play of the player in a second game level, automatically modifying at least one attribute of the second game level based on the player skill level to produce a plurality of modified attributes;
monitoring initial game play of the player in the second game level, which initial game play is implemented according to a set of level attributes that exclude the plurality of modified attributes:
identifying a difference between a current rate of progression of the player through the second game level and a reference rate of progression for the second game level;
based on an extent of the difference between the current rate of progression and the reference rate of progression, automatically selecting one of the plurality of modified attributes for activation in the second game level; and
in an automated operation using one or more computer processor devices, automatically modifying game play difficulty of the second game level by triggering the selected modified attribute of the second game level, such that subsequent game play in the second game level is implemented based at least in part on the selected modified attribute.

US Pat. No. 10,987,588

SYSTEM AND METHOD FOR OPTIMIZING VIRTUAL GAMES

Activision Publishing, In...

1. A computer-implemented method for awarding virtual game items to a plurality of players in a multi-player video game, said method being implemented in a computer having a processor and a random access memory, wherein said processor is in data communication with a display and with a storage unit, the method comprising:forming a pool of virtual game items in the computer, wherein each of said virtual game items belongs to a category;
establishing, in the computer, a lower boundary condition and an upper boundary condition for each category of said virtual game items;
for each of said plurality of players and during a multi-player video game session, selecting a value between said lower boundary condition and upper boundary condition for a given category of said virtual game items and associating said value to said category of said virtual game items;
for each of said plurality of players and during the multi-player video game session, modifying each of the selected values associated with each category of said virtual game items to yield, for each category, a modified value associated with each category of said virtual game items;
for each of said plurality of players and during the multi-player video game session, determining, for each category, if the modified value meets the lower boundary condition or the upper boundary condition; and
for each of said plurality of players and during the multi-player video game session, if the modified value is less than or equal to the lower boundary condition or the modified value is greater than or equal to the upper boundary condition, awarding a virtual game item from the given category and if the modified value is greater than the lower boundary condition and less than the upper boundary condition allocating an alternative award.

US Pat. No. 10,987,587

SYSTEM AND METHOD FOR GAME OBJECT AND ENVIRONMENT GENERATION

TAKE-TWO INTERACTIVE SOFT...

1. A system for executing a three-dimensional (3D) environment comprising:a rendering engine;
a core system logic communicatively coupled to the rendering engine;
an asset interface communicatively coupled to the core system logic and to a metadata asset store comprising a plurality of metadata records describing available assets, wherein each metadata record comprises an asset identifier, which identifies an asset, and a property tag that defines characteristics of the asset;
one or more environment systems communicatively coupled to the asset interface;
a script logic communicatively coupled to the asset interface;
wherein the asset interface is configured to:
receive a request for insertion of an object into the 3D environment from the script logic or the environment systems and to use the received request to identify a metadata asset record based on the property tag of the metadata asset record, wherein the metadata asset record corresponds to a first asset of a first asset type;
identify, based on a match tag of the metadata asset record, a second asset of a second asset type, wherein the second asset of the second asset type is compatible with the first asset of the first asset type;
automatically formulate the object requested for insertion into the 3D environment, wherein an asset combination comprising the first asset of the first asset type and the second asset of the second asset type is identified;
wherein the core system logic is configured to receive the automatically formulated object from the asset interface, and to instruct the rendering engine to load the automatically formulated object into the 3D environment; and
wherein the first asset of a first asset type is an object, and the second asset of a second asset type is a texture.

US Pat. No. 10,987,586

METHOD FOR CONTROLLING COMPUTER, RECORDING MEDIUM AND COMPUTER

GREE, INC., Tokyo (JP)

1. A computer for executing progress of a game by using a game content having a parameter value, the computer comprising:a memory configured to store a plurality of game contents associated with a plurality of players, each of the plurality of game contents being classified as a type of a plurality of types; and
circuitry configured to
receive a selection of a first set of game contents by a first player from among a plurality of game contents associated with the first player,
count, for each of the first set of game contents, a number of a second set of game contents whose type matches that of each of the first set of game contents, the second set of game contents being game contents of the plurality of game contents associated with the first player other than the first set of game contents,
determine whether or not the parameter value of each of the first set of game contents is modifiable based on the counted number of the second set of game contents,
control a display to display, for at least one of the first set of game contents, an image indicating a modified parameter value of the at least one of the first set of game contents based on a result of the determination as to whether or not the parameter value of the at least one of the first set of game contents is modifiable, and
execute an event in the game between the first player and a specific game content by comparing the parameter value of the at least one of the first set of game contents having the modified parameter value and a parameter value of the specific game content,
wherein only parameter values of game contents of the same type are modified, where game contents of different types maintain their parameter value.

US Pat. No. 10,987,585

STORAGE MEDIUM, INFORMATION-PROCESSING DEVICE, INFORMATION-PROCESSING SYSTEM, AND INFORMATION PROCESSING METHOD

Nintendo Co., Ltd., Kyot...

1. A non-transitory computer readable storage medium having stored therein instructions executable by one or more computer processors of an information processing apparatus, the instructions, when executed, causing the one or more computer processors to perform operations comprising:running a game played by players;
arranging an item appearance area in a virtual game space of the game;
upon detecting that a first player object performs a first action on the item appearance area, determining whether a right state of the first player object concerning appearance of a game item in the item appearance area is a first state or a second state, and whether an area state of the item appearance area is a first area state or a second area state;
upon determining that the right state is the first state and the area state is the first area state, determining that an item appearance condition is satisfied;
upon determining that the right state is the second state or the area state is the second area state, determining that an item appearance condition is not satisfied;
upon determining that the item appearance condition is satisfied, causing the game item to appear in the virtual game space;
upon detecting the first action performed by the first player object on the item appearance area or a second action performed by the first player object on the game item, changing the right state of the first player object for the item appearance area to the second state; and
upon detecting that the game item becomes unattainable by player objects in an appearance determination area within the virtual game space, changing the area state to the first area state.

US Pat. No. 10,987,583

METHOD AND APPARATUS FACILITATING REALISTIC PLAYER INTERACTION IN A SIMULATED SKILL GAME

Everi Games, Inc., Austi...

1. A method of controlling targets displayed during a play in a player-interactive game conducted through a gaming machine, the method including:(a) at a data processing system associated with the gaming machine, receiving a total prize amount to be awarded for the play of the player-interactive game;
(b) under control of the data processing system, determining an expected target value for a respective record from a target sequence comprising a sequence of records, wherein a number of adjacent records in the sequence of records are linked by a wave type property;
(c) under control of the data processing system, selecting a target value for the respective record from a number of different available target values, the selected target value comprising a value from among the number of different available target values that (i) bears a predefined relationship to the expected target value, and, (ii) where the respective record is linked by the wave type property, is consistent with the wave type property;
(d) under control of the data processing system, selecting a target type correlated to the selected target value;
(e) causing a prize target corresponding to the selected target type to be displayed on a display system of the gaming machine under control of the data processing system; and
(f) repeating steps (b), (c), (d), and (e) for each respective record in the target sequence until an end condition is detected for the play of the player-interactive game.

US Pat. No. 10,987,581

SYSTEM AND METHOD FOR ROTATING DROP RATES IN A MYSTERY BOX

Kabam, Inc., San Francis...

1. A system for facilitating chance-based in-game virtual item distribution of stochastically selected awards to in-game inventories of users of an online game, the system comprising:one or more physical computer processors configured by machine readable instructions to:
execute an instance of the online game and to implement the instance of the online game to facilitate participation in the online game by the users via client computing platforms;
maintain in-game inventories of virtual items under the control of the users, wherein the in-game inventories include a first in-game inventory under the control of a first user, wherein the first in-game inventory includes one or more instances of a first probability item bundle associated with a first set of potential awards usable in the online game, the first set of potential awards including a first individual award and a second individual award, wherein the first individual award is associated with a first distribution probability and the second individual award is associated with a second distribution probability, wherein the first distribution probability dictates the chance of the first probability item bundle obtaining the first individual award upon activation by the first user, wherein the second distribution probability dictates the chance of the first probability item bundle obtaining the second individual award upon activation by the first user, wherein the one or more instances of the first probability item bundle include a first instance and a second instance;
receive a first activation request from the first user for one instance of the first probability item bundle;
responsive to the first activation request, stochastically select one of the individual potential awards from the first set of potential awards in accordance with the first and second distribution probabilities associated with the individual potential awards from the first set of potential awards;
distribute the selected individual potential award to the first in-game inventory;
adjust, in response to one or more predetermined triggering criteria being met, one or both of the first distribution probability and/or the second distribution probability, wherein the one or more predetermined triggering criteria include a level of previous purchases of the first probability item bundle by the first user breaching a purchase threshold;
receive a second activation request from the first user for the second instance of the first probability item bundle;
responsive to the second activation request, stochastically select one of the individual potential awards from the first set of potential awards in accordance with the adjusted distribution probabilities associated with the individual potential award from the first set of potential awards; and
distribute the second selected individual potential awards to the first in-game inventory.

US Pat. No. 10,987,580

MEMORY MANAGEMENT IN GAMING RENDERING

GOOGLE LLC, Mountain Vie...

1. A method of rendering image frames for online gaming sessions, comprising:executing on one or more CPUs a plurality of online gaming sessions in parallel for a gaming title;
rendering by one or more GPUs a plurality of image frames for each of a plurality of online gaming sessions using a first sequence of compiled shaders;
identifying a performance criterion for the plurality of online gaming sessions associated with the gaming title;
collecting real-time usage statistics characterizing execution of each of the online gaming sessions; and
based on the real-time usage statistics, modifying a first shader in the first sequence of compiled shaders to improve performance of the first sequence of compiled shaders with respect to the performance criterion for the plurality of online gaming sessions, thereby creating a modified first sequence of compiled shaders;
establishing a shader hash table that associates each of a plurality of performance criteria with a respective sequence of compiled shaders, including associating the performance criterion and the first sequence of compiled shaders in the shader hash table; and
storing the shader hash table in a shader cache of a memory.

US Pat. No. 10,987,579

2.5D GRAPHICS RENDERING SYSTEM

ELECTRONIC ARTS INC., Re...

1. A computing system comprising:a network communications interface configured to communicate via a network with a server that is generating a virtual 3D environment;
a memory; and
one or more processors configured to execute computer-readable instructions to perform steps comprising:
receiving, from the server over the network, a 2D texture for an object in the virtual 3D environment;
receiving first frame data comprising:
an identification of the object;
locations of vertexes of a 2D mesh for the object generated based in part on a field of view of a virtual character within the virtual 3D environment; and
depth data for the object generated based in part on the field of view of the virtual character within the virtual 3D environment;
storing the texture in the memory;
mapping the texture onto the locations of the vertexes of the 2D mesh for the object, wherein the locations of the vertexes of the 2D mesh are locations of parts of a 3D object in the virtual 3D environment projected onto a 2D plane as seen from a viewpoint of the virtual character;
rasterizing a first frame of a video based in part on the depth data and the texture mapped onto the locations of the vertexes of the 2D mesh for the object;
receiving second frame data comprising:
the identification of the object; and
updated locations of vertexes of the 2D mesh for the object;
mapping the texture to the updated locations of the vertexes of the 2D mesh for the object; and
rasterizing a second frame of the video based in part on the depth data and the texture mapped onto the updated locations of the vertexes of the 2D mesh for the object.

US Pat. No. 10,987,575

SERVER AND METHOD FOR PROVIDING GAME SERVICE BASED ON INTERFACE EXPRESSING AUDIO VISUALLY

Netmarble Corporation, S...

1. A game service providing server, comprising,a processor configured to generate a game interface in which an audio generated in the vicinity of a game character of a user is visualized through an interface element, and provide a game service based on the generated game interface,
wherein the processor is configured to:
generate the game interface including a plurality of interface elements arranged in preset regions,
adjust at least one of the interface elements based on audio data related to the audio, wherein when the audio corresponds to an audio generated intermittently, the processor is configured to control the interface element to blink based on a generation interval of the audio,
generate the visualized game interface based on a result of the adjusting, and
electronically interface with a user terminal.

US Pat. No. 10,987,574

HEAD MOUNTED DISPLAY

Sony Interactive Entertai...

1. A head mounted display (HMD), comprising,a housing;
a view port of the housing, the view port having a screen for rendering a virtual reality scene;
a communications device for exchanging data over a network;
a depth camera integrated in the housing and oriented to capture depth data of an environment in front of the housing; and
a processor is configured to use the depth data captured by the depth camera to identify real objects in the environment, wherein a real object is rendered into the virtual reality scene, the real object being tracked such that movements of the real object are shown as movements in the virtual reality scene;
wherein the real object captured by the depth camera in the environment is a hand of a user wearing the HMD, and said hand of the user is rendered as a virtual hand, and movements of the virtual hand are displayed in the screen of the viewport from a perspective that is in front of the user, wherein at least part of an arm of the user extended into the virtual reality scene in front of the user provides for the virtual hand to appear depth-wise as a continuation of the arm to the virtual hand.

US Pat. No. 10,987,572

INFORMATION PROCESSING SYSTEM, STORAGE MEDIUM STORING INFORMATION PROCESSING PROGRAM, INFORMATION PROCESSING APPARATUS, AND INFORMATION PROCESSING METHOD

Nintendo Co., Ltd., Kyot...

1. An information processing system comprising a first apparatus, a second apparatus and an information processing apparatus, wherein:the first apparatus includes:
a first sensor configured to detect a movement of the first apparatus attached to a lower body of a user; and
a first transmitter configured to transmit an output of the first sensor;
the second apparatus includes:
a second sensor configured to detect a movement of the second apparatus attached to an upper body of the user or held by a hand of the user; and
a second transmitter configured to transmit an output of the second sensor, wherein:
the information processing apparatus includes a computer configured to:
receive the outputs transmitted from the first sensor and the second sensor; and
cause a virtual object to continue to perform a first action in a virtual space while the received outputs from the first sensor and the second sensor both satisfy a condition.

US Pat. No. 10,987,571

PUZZLE WITH CONDUCTIVE PATH

SPHERO, INC., Boulder, C...

1. A toy construction kit, comprising:first, second, and third functionally distinct interengagable construction blocks, each of the construction blocks defining one or more indentations and one or more protrusions, at least one protrusion of the one or more protrusions extending from a side surface of each of the construction blocks, the side surface of each construction block being disposed substantially perpendicular to a surface of that construction block that contacts a support surface when placed thereon, each of the construction blocks including a magnet configured to magnetically engage a magnet on another construction block,
the first constructions block includes or is coupled to a power source to power at least part of the kit, the second construction block includes a sensor for sensing a physical phenomenon, the third construction block includes an electrical component that can be electrically powered from the power source,
upon coupling together any two of construction blocks an electrical connection is formed between the two construction blocks,
upon coupling together the first construction block to the second construction block and the second construction block to the third construction block, an electrical circuit is formed such that the electrical component is activated in response to a physical phenomenon sensed by the sensor.

US Pat. No. 10,987,570

DEVICE TO PROVIDE NETWORK ACCESS TO ENTERTAINMENT MACHINE

Spinner Systems, Inc., L...

1. A system, comprising:a network interface;
a logic circuit coupled to the network interface and configured to:
receive a display signal associated with a pinball machine display;
interpret the display signal; and
transmit a network message to the pinball machine display via the network interface based at least in part on the interpretation of the display signal;
a first communication interface coupled to a pinball machine display driver board and to the logic circuit, wherein the first communication interface is configured to:
receive the display signal from the pinball machine display driver board, and
provide the display signal to the logic circuit; and
a third communication interface coupled to a pinball RAM board and to the logic circuit; and
wherein the logic circuit is further configured to:
receive a memory state associated with a pinball RAM associated with the pinball RAM board;
interpret the memory state; and
transmit a network message via the network interface based at least in part on the interpretation of the memory state.

US Pat. No. 10,987,569

PLAYING CARD

ANGEL PLAYING CARDS CO., ...

1. A playing card, comprising:a first layer on which a suit and a rank are printed entirely with a substantially carbon free ink such that the printed suit and rank transmit infrared rays;
a second layer on a surface of which a pattern is printed; and
an intermediate layer arranged between the first and second layers and having a dark color that impedes transmission of visible rays between the first and second layers, thereby obscuring visibility, from the surface of the second layer, of the suit and the rank printed on the first layer.

US Pat. No. 10,987,568

AUTO SCORER FOR DISPLAYING ROLLS DECIDING OUTCOME

1. A bowling auto scorer for displaying rolls deciding an outcome comprising:a processor and a memory that stores an instruction, wherein when the processor executes the instruction, the processor performs processes of:
calculating maximum possible scores of players at any time during a game when performing a bowling game in a bowling alley by adding scores that would be attained by knocking down all pins with no missed pins in subsequent bowling rolls, comparing the calculated maximum possible scores with those of other players, and displaying middle rankings at any time during the game based on the calculated maximum possible scores for each player, and the score differences therebetween, the score differences therebetween being an integer greater than or equal to zero; and
displaying final rankings and roll results required for deciding an outcome on a screen.

US Pat. No. 10,987,567

SWING ALERT SYSTEM AND METHOD

X Factor Technology, LLC,...

1. A method of using a swing alert system and one or more previously determined swing metrics associated with a batter to provide alerts in real-time to the batter to hit a moving ball travelling along a flight path, the swing alert system having (i) a swing alert device storing the one or more previously determined swing metrics, (ii) one or more sensors configured to determine a velocity of the moving ball, and (iii) an alert unit configured to generate at least one of a sound, light, vibration, or tactile signal, the method comprising:receiving, via the swing alert device, an indication corresponding to an upcoming pitching event that causes the ball to travel along the flight path;
capturing metrics of the moving ball by—measuring, via the one or more sensors, a velocity of the moving ball travelling along the flight path, and
calculating, via the swing alert device and based on the velocity of the moving ball, when the moving ball will reach a hitting location target proximate the batter;
merging, via the swing alert device, the captured metrics of the moving ball and the one or more previously determined swing metrics associated with the batter in real-time to determine when the batter must initiate a swing of a bat in order to hit the moving ball at the hitting location target, wherein the one or more previously determined swing metrics includes an overall swing time of the batter comprising—a swing delay time, wherein the swing delay time corresponds to a first period of time between an instruction to swing and an initiation of forward motion of the bat, and
a swing time, wherein the swing time corresponds to a second period of time between the initiation of forward motion of the bat and a contact between the bat and the ball; and
providing, via the alert unit, an alert to the batter instructing the batter to swing in order to hit the moving ball at the hitting location target, wherein the alert includes at least one of the sound, light, vibration, or tactile signal.

US Pat. No. 10,987,565

EXERCISE MACHINE EMERGENCY MOTOR STOP

Tonal Systems, Inc., San...

1. An exercise machine, comprising:a motor having a plurality of power leads; and
a relay coupled to the plurality of power leads, wherein:
a default state of the relay is to short the plurality of power leads together to cause an opposing back EMF to motion in the motor at least in part to self-brake the motor; and
the relay comprises a safety input configured to receive a safety signal to maintain the relay in an open state.

US Pat. No. 10,987,563

BATTING TRAINING DEVICE

1. A batting training device, incorporating a ball which is arranged secured in an aerial position to be batted, comprisinga column comprising a tube incorporated in the column and arranged vertically with axial freedom of movement,
an elastic cord passing through said tube, a lower end of said elastic cord is fastened to a lower end of the tube, while at an upper end of said elastic cord the ball is fastened, the ball resting on an upper end of the tube, and
the tube comprising a plurality of segments, each segment comprising a longitudinal guide slot with respect to a rod, the longitudinal guide slot having a bend which communicates with the longitudinal guide slot of an adjacent segment, wherein in a last lower segment, the bend in the corresponding longitudinal guide slot communicates with a return channel which runs along an entire length of the plurality of segments of the tube and which communicates with the longitudinal guide slot of an upper segment.

US Pat. No. 10,987,561

HITTING PRACTICE DEVICE

1. A hitting practice device that facilitates practice of an initial contact and a follow-through of a hit, comprising:a pivoting base;
a post projecting upward from the pivoting base, the post having a padded upper portion; and
a dampener attached to the post, wherein the dampener absorbs at least a part of the initial contact of the hit aimed at the padded upper portion, and wherein at least a part of the pivoting base is configured to pivot relative to a surface on which the pivoting base rests during the follow-through of the hit,
a stopper configured to prevent the post from pivoting beyond a recovery angle, wherein the stopper includes a stopper leg configured to engage the surface on which the pivoting base rests prior to the post pivoting beyond the recovery angle.

US Pat. No. 10,987,559

ADJUSTABLE GOLF CLUB

1. An adjustable golf club comprising:a club head;
a shaft having a shaft insert supporting a grip connector; and
a grip assembly having a reinforcing sleeve, the reinforcing sleeve configured to be removably secured to the grip connector, and including an open proximal end, a tubular mid-section, and a distal end having a threaded section, the threaded section defining a diameter that is smaller than an inner diameter of the tubular mid-section, the reinforcing sleeve being a two piece member wherein the distal end comprises a cup having threads formed on an inner diameter, the cup attached to a hollow section.

US Pat. No. 10,987,558

CUSTOM GRIP

1. A method of forming a customized putter grip comprising:orienting a first grip member, having a first contact surface, and a second grip member having a second contact surface, of the customized putter grip in a predetermined orientation, selected from a set of angles between the first contact surface and the second contact surface;
fixing the first grip member and the second grip member in the predetermined orientation;
coupling the customized putter grip with the fixed first grip member and the second grip member to a shaft of a golf club; and
coupling the first grip member within a first portion of a unitary grip cover, and the second grip within a second portion of the unitary grip cover, wherein the first grip member and the second grip member are completely contained within the unitary grip cover.

US Pat. No. 10,987,557

FLEXIBLE GOLF CLUB GRIP WITH STABLE CAP

EATON INTELLIGENT POWER L...

1. A flexible grip for a golf club shaft comprising:(a) a tubular member of elastomeric material having an open end for being received over the club shaft and an end distal the open end having a cap received thereover;
(b) a cavity formed in an exterior surface of the cap, wherein the cavity is configured for receiving a sensor therein; and
(c) a plurality of air channels formed in the inner periphery of the cavity operative for providing air movement about a sensor upon receipt thereof in the cavity.

US Pat. No. 10,987,554

GOLF CLUB

SUMITOMO RUBBER INDUSTRIE...

1. A golf club comprising:a head;
a shaft including a tip end and a butt end;
a grip; and
a weight member that is located in a butt end region having a distance from a butt end of the grip of less than or equal to 100 mm, wherein
the grip and the weight member constitute a grip-weight portion,
the shaft, the grip, and the weight member constitute a shaft-grip-weight portion,
the head has a weight of greater than or equal to 195 g,
the grip-weight portion has a weight of greater than or equal to 40 g,
the shaft has a weight of less than or equal to 40 g,
the golf club has a weight of greater than or equal to 275 g and less than or equal to 300 g, and
W1/W3 is greater than or equal to 0.40, where W1 represents a weight (g) of the butt end region, and W3 represents a weight (g) of the shaft-grip-weight portion.

US Pat. No. 10,987,553

GOLF CLUB

SUMITOMO RUBBER INDUSTRIE...

1. A golf club comprising:a head;
a shaft including a tip end and a butt end;
a grip; and
a weight member that is located in a butt end region having a distance from a butt end of the grip of less than or equal to 100 mm, wherein
the grip and the weight member constitute a grip-weight portion,
the shaft, the grip, and the weight member constitute a shaft-grip-weight portion,
the golf club has a length of greater than or equal to 45.0 inches,
the golf club has a weight of less than 295 g,
the head has a weight of greater than or equal to 195 g,
the grip-weight portion has a weight of greater than or equal to 40 g, and
W1/W3 is greater than or equal to 0.40, where W1 represents a weight (g) of the butt end region, and W3 represents a weight (g) of the shaft-grip-weight portion.

US Pat. No. 10,987,548

MULTI-PIECE SOLID GOLF BALL

Bridgestone Sports Co., L...

1. A multi-piece solid golf ball comprising a core, an intermediate layer and a cover, wherein the core is formed of a rubber composition, the cover is formed primarily of a polyurethane material, the ball has a surface hardness and the sphere obtained by encasing the core with the intermediate layer (intermediate layer-encased sphere) has a surface hardness which together satisfy the following conditionsurface hardness (Shore C hardness) of ball?surface hardness (Shore C hardness) of intermediate layer-encased sphere,
and in an impact test carried out by striking the ball with a driver at a head speed of 40 m/s, the sum t1+t2 of the time t1 required from contact initiation between the driver and the ball for deformation of the ball to reach a maximum value and the time t2 required from the state of maximum ball deformation for the ball and driver clubface to separate is at least 705 microseconds, and
wherein the core has a hardness profile in which, letting Cc be the Shore C hardness at the core center, Cs be the Shore C hardness at a surface of the core, CM be the Shore C hardness at a midpoint M between the center and surface of the core, CM+2.5, CM+5.0 and CM+7.5 be the respective Shore C hardnesses at positions 2.5 mm, 5.0 mm and 7.5 mm from the midpoint M toward the core surface side and CM?2.5, CM?5.0 and CM?7.5 be the respective Shore C hardnesses at positions 2.5 mm, 5.0 mm and 7.5 mm from the midpoint M toward the core center side, the following surface areas A to F:
surface area A: ½×2.5×(CM?5.0?CM?7.5)
surface area B: ½×2.5×(CM?2.5?CM?5.0)
surface area C: ½×2.5×(CM?CM?2.5)
surface area D: ½×2.5×(CM+2.5?CM)
surface area E: ½×2.5×(CM+5?CM+2.5)
surface area F: ½×2.5×(CM+7.5?CM+5)
satisfy the condition
(surface area D+surface area E+surface area F)?(surface area A+surface area B+surface area C)>0.

US Pat. No. 10,987,545

GRADUATED-BUOYANCY SWIMMING FLOAT APPARATUS

TURTLE PACK LTD

1. A wearable graduated-buoyancy swimming float apparatus comprising a plurality of floats wherein at least some of the floats are configured to be nestable together, wherein the floats have a rounded shell shape and have corresponding concave and convex opposing surfaces such that the floats are nestable by the convex surface of a float fitting into the concave surface of another of the floats, and further comprising at least one strap and wherein at least some of the floats are configured to be threadable by the at least one strap to hold the floats together.

US Pat. No. 10,987,539

CLIMBING EXERCISE APPARATUS

1. A climbing exercise apparatus, comprising:a frame including a base, a stanchion extending generally vertically upward from said base and a generally vertically extending subassembly frame fixedly secured to said base, wherein said subassembly frame includes left and right track members extending generally vertically in spaced, parallel alignment with one another;
left and right elongated reciprocal members movably supported by a respective left or right track member;
left and right hand grips coupled to a respective left or right elongated reciprocal member, each said hand grip movable from a first horizontal position relative to a respective said left or right elongated reciprocal member to a second horizontal position for a user to perform homolateral or contralateral exercise movements, wherein in a contralateral exercise configuration the right hand grip coupled to the right elongated reciprocal member is moveable from a right side of the exercise apparatus to a left side of the exercise apparatus and usable with a left hand of a user, and the left hand grip coupled to the left elongated reciprocal member is movable from the left side of the exercise apparatus to the right side of the exercise apparatus and usable with a right hand of a user; and
left and right foot supports secured proximate a lower distal end of a respective left or right elongated reciprocal member.

US Pat. No. 10,987,538

MODULAR SPACE-SAVING EXERCISE EQUIPMENT

1. A modular exercise system comprising:a first support frame module having a plurality of frame members comprising a pair of upright frame members defining opposing lateral sides of the first support frame module, each upright frame member being joined to an adjacent frame member and oriented in a common plane;
a weight source mounted on the first support frame module;
a plurality of pulleys mounted to different frame members of the first support frame module;
a cable running from the weight source over the plurality of pulleys to connect the weight source to a plurality of manual actuators for performing a resistance exercise in use, the weight source and the plurality of pulleys being located between the pair of upright frame members;
the first support frame module comprising one or more fixings configured to hold the modular exercise system in an upright orientation to a wall for use; and
a further support frame module also being two-dimensional in form and having one or more attachment formations such that the further support frame module is configured to be attachable to the first support frame module and/or the wall in an orientation within the common plane, wherein the further support frame module comprises one or more further manual actuators;
wherein at least one of the pair of upright frame members of the first support frame module comprises a cable opening to allow the cable to pass through at least one of the pair of upright frame members from the first support frame module to the further support frame module;
wherein the plurality of manual actuators are provided within the first support frame module, such that the first support frame module is configurable as a single stand-alone piece of exercise equipment, offering a plurality of manual actuator configurations based on the cable and the plurality of pulleys within the first support frame module alone and the further support frame module is configured to be selectively useable to offer one or more further exercise options for a user by the cable passing from the weight source of the first support frame module through said cable opening to the further support frame module.

US Pat. No. 10,987,534

EXERCISE GARMENT

John G. DeYoung, Santa M...

1. An exercise pant garment comprising:an upwardly disposed waist,
a seat spaced apart from and connected to a pant front, the seat and the pant front connected to the upwardly disposed waist,
a first leg section spaced apart from a second leg section, wherein each of the first leg section and second leg section is connected to the seat and the pant front, the first and second leg sections each having an inner perimeter side and an outer perimeter side, and
a first elongated fabric, exercise band coupled to the first leg section and comprising a first free end, a second free end, and a middle portion between the first free end and second free end being permanently fixed by stitching or removably attached by snaps, hook and loop, or zippers about a knee area of the first leg section in relation to at least a portion of each of the inner perimeter side and outer perimeter side of the first leg section, the first elongated fabric, exercise band having a length adapted to at least wrap around a first leg of a wearer once,
a second elongated fabric, exercise band coupled to the second leg section and comprising a first free end, a second free end, and a middle portion between the first free end and second free end being permanently fixed by stitching or removably attached by snaps, hook and loop, or zippers about a knee area of the second leg section in relation to at least a portion of the inner perimeter side and outer perimeter side of the second leg section, the second elongated fabric, exercise band having a length adapted to at least wrap around a second leg of the wearer once,
wherein each of the middle portions of the first and second elongated fabric, exercise bands remain attached to the first and second leg sections when each of the first and second free ends of the first and second elongated fabric, exercise bands are in a first, second, third and fourth configurations,
the first configuration comprising wherein each the first and second free ends of the first and second elongated fabric, exercise bands wrap around the first and second leg sections, respectively, whereby each of the first and second elongated fabric, exercise bands are securely mounted to the first and second leg sections, respectively, during periods of non-use at the inner and outer perimeter sides of the first and second leg sections,
the second configuration comprising wherein each the first and second free ends of the first and second elongated fabric, exercise bands are detached from each other at the outer perimeter side of each of the first and second leg sections whereby each the first and second free ends of the first and second elongated fabric, exercise bands are capable of hanging from each of the first and second leg sections such that end portions of the first and second free ends of the first and second elongated fabric, exercise bands extend below a bottom perimeter of each of the first and second leg sections,
the third configuration comprising wherein the first and second free ends of the first elongated fabric, exercise band extend from the outer perimeter side to the inner perimeter side of the first leg section to attach to at least one of the first free end and the second free end of the second elongated fabric spanning a first space between the first leg section and second leg section and wherein the first and second free ends of the second elongated fabric, exercise band extend from the outer perimeter side to the inner perimeter side of the second leg section to attach to at least one of the first free end and the second free end of the first elongated fabric spanning the first space between the first leg section and second leg section,
the fourth configuration comprising wherein at least one the first and second elongated fabric, exercise bands are attached to a stationary object whereby the first and second free ends of the first elongated fabric, exercise band or wherein the first and second free ends of the second elongated fabric, exercise band extend from the outer perimeter side of their respective said first and second leg sections to attach the stationary object.

US Pat. No. 10,987,533

PLAY STRUCTURE CLAMP AND SYSTEM

Landscape Structures, Inc...

1. A climbing structure comprising:a first support post;
a second support post;
a panel, configured to be coupled to the first and second support post, comprising:
a plurality of post connection mechanisms distributed around an outside perimeter of the panel such that a post connection point on one side of the panel is not in a same plane with a post connection mechanism on an opposite side of the panel; and
a clamp configured to couple the panel to the second post through engagement of the clamp to one of the post connection point mechanisms.

US Pat. No. 10,987,532

BODY COACH

1. An exercise frame comprising:a. a base with a bottom surface having, four supports, wherein each of the four supports telescopically houses either a wheeled or an un-wheeled stabilizer, and on an upper surface of the base, a handle and two brackets, wherein each of the two brackets is hingedly connected to a respective one of two pivoting posts;
b. wherein each of the two pivoting posts extends a respective retractable slat at heights of 5.50?, 6.00?, and 7.00? relative to the base's upper surface, and wherein each of the retractable slats has a dip handle and a pullup bar holder connected at an upper most part thereof;
c. wherein each of the two brackets has a respective sit up bar holder located thereon;
d. an assistance or resistance band connected in a space between the two pivoting posts by retaining hooks positioned about each of the two pivoting posts, such that the assistance or resistance band is vertically adjustable at heights from 16.00? to 28.00? relative to the base's upper surface; and
e. wherein a weighted pullup bar is configured to be connected to the exercise frame at each of the pullup bar holders or at each of the sit up bar holders.

US Pat. No. 10,987,530

AUTOMATIC FIRE EXTINGUISHER SYSTEM HAVING A SAFETY ASSEMBLY

KIDDE TECHNOLOGIES, INC.,...

1. An automatic fire extinguisher system, comprising:a valve housing having an inlet port in fluid communication with an outlet port, the valve housing having a safety block disposed opposite the outlet port;
an extinguisher bottle configured to receive an extinguishing agent, the extinguisher bottle in fluid communication with the inlet port;
a valve assembly movable between a closed position in which the valve assembly inhibits fluid communication between the inlet port and the outlet port and an open position in which the valve assembly permits fluid communication between the inlet port and the outlet port; and
a safety assembly disposed within the valve housing, the safety assembly movable between a safe position in which the safety assembly inhibits movement of the valve assembly from the closed position towards the open position and an armed position in which the safety assembly permits movement of the valve assembly from the closed position towards the open position, the safety assembly includes:
an engagement member slidably disposed within the outlet port;
a blocking member at least partially disposed within the safety block that includes a first blocking member portion and a second blocking member portion; and
an extension member connected to a first engagement feature of the engagement member and that extends at least partially through the first blocking member portion; and
wherein the valve housing defines an opening disposed opposite the outlet port, wherein the second blocking member portion extends through the opening and into a cavity defined by the safety block.

US Pat. No. 10,987,529

FIRE EXTINGUISHER

Nottingham Spirk Design A...

1. A fire extinguisher comprising:a housing;
a vessel positioned within the housing, the vessel retaining a fire suppression agent therein;
an actuator;
a discharge port operatively coupled to the vessel by the actuator;
a puncturable high pressure gas cartridge positioned within the housing, the actuator operable to puncture the puncturable high pressure gas cartridge and to cause the fire suppression agent to combine with gas from the puncturable high pressure gas cartridge to propel the fire suppression agent through the discharge port; and
an electrical connector positioned on the housing, the electrical connector capable of operatively securing to and being electrically connected to a standard electrical outlet, the electrical connector containing at least two-prongs extending therefrom,
wherein the fire extinguisher includes a child safety feature in which an initial depression of the actuator does not expel the fire suppression agent, but a second depression of the actuator expels the fire suppression agent.

US Pat. No. 10,987,527

NASAL AIR FILTRATION DEVICE

7. A nasal air filtration device, comprising:a pair of nostril tubes, each of the nostril tubes comprising a filter at one end and an ionic plate at the other end,
a cap provided at each of the nostril tubes, wherein the cap comprises a plurality of openings, wherein the cap is coupled to the nostril tubes at the ionic plate;
a base tube coupled to the nostril tubes, wherein the base tube comprises an exhaust channel; and
a first housing and a second housing coupled to the base tube at far ends, wherein the first housing comprises a battery, and wherein the second housing comprises a fan;
wherein the nostril tubes are adapted to be placed inside nostrils of a user, such that when the user inhales, the fan is operated to draw air into the base tube, and the air is made to pass through the filter and the ionic plate provided at the nostril tubes into the nostrils via the openings, wherein when the user exhales, the air is released into the atmosphere through the exhaust via the nostril tubes.

US Pat. No. 10,987,525

DESCENDING APPARATUS AND METHODS FOR USE OF SAME

CMC Rescue, Inc., Goleta...

1. A system, comprising: a body comprising a handle and a pocket, wherein a pivotable bollard is located in the pocket, the bollard comprising an outer surface wherein a defined path for a line wraps around more than half a circumference of the bollard from a beginning to an end of the defined path on the bollard, the defined path includes a second open end of a line-passing through-hole at a bottom of the bollard and the line-passing through-hole passes through the bollard to a first open end at a top of the bollard, the second open end of the line-passing through-hole located adjacent to the defined path, and wherein the bollard pivots around a pin having a rotation axis, the beginning of the defined path offset along the rotation axis with respect to the end of the defined path.

US Pat. No. 10,987,523

PLATFORM FOR INTENSITY MODULATED RADIATION THERAPY

The Regents of the Univer...

1. A method of generating a radiation treatment plan using a radiotherapy device comprising a sparse orthogonal collimator comprising a first bank of individually longitudinally movable elongate leaves, and a second bank of individually longitudinally movable elongate leaves the second bank being disposed in an opposed relationship to the first bank, a third bank of individually longitudinally movable elongate leaves, and a fourth bank of individually longitudinally movable elongate leaves the fourth bank being disposed in an opposed relationship to said third bank, and said first bank and said second bank being oriented orthogonal to said third bank and fourth bank, and said first bank, second bank, third bank, and fourth bank each individually contain from two to four leaves, said method comprising:providing a fluence map for said radiation treatment plan; and
generating using a computer a time sequence of sparse orthogonal collimator leaf settings from said fluence maps, wherein said generating comprises:
representing a desired fluence map using discrete Haar wavelet coefficients; and
optimizing Haar fluence using a direct aperture regularization approach centered on dose domain optimization wherein sparsity is used to limit total number of Haar coefficients and thus total number of apertures while maintaining dosimetric quality; and
generating and writing instruction files to implement said time sequence of sparse orthogonal collimator leaf settings to a tangible medium accessible for execution by the radiotherapy device.

US Pat. No. 10,987,521

SYSTEM AND METHODS FOR TREATING BRAIN RELATED CONDITIONS WITH PHOTOBIOMODULATION THERAPY

1. A method of treating brain disease and/or brain injuries, comprising:determining a treatment protocol for a subject having a particular brain disease and/or brain injury, said treatment protocol including a plurality of treatments, each treatment including application of light to the brain at a predetermined light frequency of 2.5 Hz. 10 Hz. or 1.25 kHz, and a predetermined duration of application of light, at respective positions in a pattern on the subject's skull in dependence upon the particular brain disease and/or brain injury being treated, wherein the treatment protocol comprises 18 treatments 3 times a week for 6 weeks or 2 times a week for 9 weeks on non-consecutive days, and wherein the treatment protocol is only to be used with a class 3 b laser or lower: and
for each treatment, applying a light probe perpendicularly to the subject's skull at respective positions in the pattern that is predetermined to provide effective treatment for the particular brain disease and/or brain injury, and repeating application of light at said predetermined light frequency, for said predetermined duration of application of light, at each position, wherein the light probe is applied perpendicularly to each respective position on the subject's skull for about a minute to emit the light in a continuous mode or a pulsed mode, and the light from the light probe is in the form of an alternating square wave having a wavelength of 810 nm;
wherein the pattern comprises one of: a 9-point treatment pattern, an 11-point treatment pattern, and a 13-point treatment pattern,
wherein in each treatment pattern, the light probe is adapted to move from one point to another point for treatment of each point, individually at a time.

US Pat. No. 10,987,518

TERMINATING PACEMAKER MEDIATED TACHYCARDIA (PMT) IN DUAL CHAMBER LEADLESS PACEMAKER SYSTEMS

Pacesetter, Inc., Sylmar...

1. A method for terminating a pacemaker mediated tachycardia (PMT), the method for use by an implantable system including an atrial leadless pacemaker (aLP) and a ventricular leadless pacemaker (vLP), the aLP configured to be implanted within or on an atrial cardiac chamber, wherein during a period that the PMT is not detected the aLP is also configured to deliver an atrial pacing pulse to the atrial cardiac chamber in response to a PA interval expiring without an intrinsic atrial event being detected during the PA interval, the vLP configured to be implanted within or on a ventricular cardiac chamber, and the aLP and the vLP capable of performing implant-to-implant (i2i) communication with one another, the method comprising:the aLP performing atrial sensing to thereby monitor for intrinsic atrial events in the atrial cardiac chamber;
the vLP performing ventricular sensing to thereby monitor for intrinsic ventricular events in the ventricular chamber;
one of the aLP or the vLP detecting the PMT;
the one of the aLP or the vLP that detected the PMT informing the other one of the aLP or the vLP, via an i2i communication, that the PMT was detected;
the aLP, in response to the PMT being detected, initiating a PMT PA interval that is shorter than the PA interval that the aLP would otherwise use for atrial pacing if the PMT was not detected; and
the vLP, in response to the PMT being detected, initiating a PMT PV interval that is longer than the PMT PA interval;
wherein the PA interval specifies when an atrial pacing pulse should be delivered by the aLP to the atrial cardiac chamber following an intrinsic atrial sensed event, in response to the PA interval expiring without another intrinsic atrial event being detected during the PA interval, during a period that the PMT has not been detected;
wherein the PMT PA interval specifies when an atrial pacing pulse should be delivered by the aLP to the atrial cardiac chamber following an intrinsic atrial sensed event, in response to the PMT PA interval expiring without another intrinsic atrial event being detected during the PMT PA interval, during a period that the PMT has been detected; and
wherein the PMT PV interval specifies when a ventricular pacing pulse should be delivered by the vLP to the ventricular cardiac chamber following an intrinsic atrial sensed event, in response to the PMT PV interval expiring without an intrinsic ventricular event being detected during the PMT PV interval, during a period that the PMT has been detected.

US Pat. No. 10,987,515

MANAGEMENT OF ELECTRICAL STIMULATION THERAPY

Medtronic, Inc., Minneap...

1. A method comprising:delivering, by a medical device via a plurality of electrodes, electrical stimulation therapy according to a plurality of therapy parameter sets to a plurality of respective tissue sites of a patient, the electrical stimulation therapy treating a condition of the patient, and wherein delivering the electrical stimulation therapy according to the plurality of therapy parameter sets comprises one of: simultaneously delivering the electrical stimulation therapy according to each therapy parameter set of the plurality of therapy parameter sets, or delivering the electrical stimulation therapy according to each therapy parameter set of the plurality of therapy parameter sets on a time-interleaved basis with other therapy parameter sets of the plurality of therapy parameter sets;
subsequent to delivering the electrical stimulation therapy according to the plurality of therapy parameter sets, selecting a plurality of subsets of the plurality of therapy parameter sets, wherein each subset of the plurality of therapy parameter sets includes at least one therapy parameter set of the plurality of therapy parameter sets and less than all of the plurality of therapy parameter sets, and wherein electrical stimulation therapy is delivered according to each subset of the plurality of therapy parameter sets via a respective set of electrodes different from sets of electrodes that deliver other subsets of the plurality of therapy parameter sets;
iteratively delivering, by the medical device, electrical stimulation therapy according to the subsets of the plurality of therapy parameter sets to the patient via the respective sets of electrodes;
receiving, for each of the subsets of the plurality of therapy parameter sets, feedback from the patient indicating whether the subset of the plurality of therapy parameter sets treated the condition of the patient; and
selecting, based on the feedback from the patient, at least one subset of the plurality of therapy parameter sets that treat the condition of the patient for defining subsequent delivery of electrical stimulation therapy to the patient.

US Pat. No. 10,987,513

MODULAR IMPLANT DELIVERY AND POSITIONING SYSTEM

IotaMotion, Inc., Iowa C...

1. A system for robotically assisted implantation of an implant in a patient, the system comprising:an external positioning unit including: at least two rollers arranged and configured to engage, through compression between respective radial outer surfaces of the at least two rollers, at least a portion of an elongate member of the implant, and to robotically deliver and position the implant into a target implantation site; and a manual drive-wheel coupled to at least one of the at least two rollers, the manual drive-wheel configured to enable manual rotation of the at least one of the at least two rollers;
a control console communicatively coupled to the external positioning unit, the control console including a controller circuit configured to generate a motion control signal, according to a specific motion control instruction, for controlling the external positioning unit to robotically deliver and position the implant into the target implantation site; and
at least one motor included in the external positioning unit or in the control console, the at least one motor configured to robotically drive at least one of the at least two rollers via a power transmission unit.

US Pat. No. 10,987,512

SYSTEM AND METHOD FOR PROVIDING IONTOPHORESIS AT TYMPANIC MEMBRANE

TUSKER MEDICAL, INC., Me...

1. An apparatus, comprising:a body defining a channel, the channel configured to be in fluid communication with an ear canal;
an elongate shaft extending through the channel into the ear canal, the elongate shaft defining a fluid path;
a sealing element disposed around a portion of the body, the sealing element configured to form a fluid seal against a surface of the ear canal;
a distal portion defining an aperture, the distal portion configured to receive iontophoresis fluid from the fluid path and deliver the iontophoresis fluid via the aperture into the ear canal such that the iontophoresis fluid fills a portion of the ear canal and the channel;
an electrode disposed within the channel and configured to drive delivery of ions in the iontophoresis fluid into a tympanic membrane; and
a control unit configured to deliver current to the electrode to drive the delivery of the ions and to detect a presence of an air bubble by measurement of a capacitance associated with the electrode.

US Pat. No. 10,987,511

STIMULATION SYSTEMS AND RELATED USER INTERFACES

Lungpacer Medical Inc., ...

1. A system for stimulating body tissue, the system comprising:a user interface; and
a control unit including a processor and a non-transitory computer readable medium storing instructions that, when executed by the processor, causes the processor to identify an electrode combination and determine a threshold charge for use in stimulating the body tissue, based at least partially on input received via the user interface.

US Pat. No. 10,987,510

SYSTEMS AND METHODS FOR AUTOMATED MUSCLE STIMULATION

Sage Products, LLC, Cary...

1. A method of electrically stimulating a target muscle of a patient, comprising:placing at least one stimulation electrode in electrical contact with the target muscle;
applying an electrical signal to the stimulation electrode;
obtaining a signal from a sensing element placed on the patient, wherein the sensing element is configured to detect at least one biological parameter of the patient associated with contraction of the target muscle caused by the application of the electrical signal; and
adapting stimulation of the target muscle by the at least one stimulation electrode using the obtained signal.

US Pat. No. 10,987,509

SYSTEMS INCLUDING NEUROMUSCULAR STIMULATION CUFF

BATTELLE MEMORIAL INSTITU...

1. A system for thought-controlled neuromuscular stimulation, comprising:a sensor for monitoring or recording neural signals;
a neural signal processor for receiving neural signals and processing the neural signals into a re-encoded signal; and
a neuromuscular stimulation cuff for delivering neuromuscular stimulation according to the re-encoded signal;
wherein the neuromuscular stimulation cuff comprises a plurality of flexible printed circuit boards arranged as a plurality of fingers, each finger having including:
a polyimide base layer; and
an etched conductive circuit layer fabricated onto the polyimide base layer, the etched conductive circuit layer including a plurality of electrodes disposed spaced along the finger.

US Pat. No. 10,987,507

METHODS AND DEVICES FOR LOCALIZING COMPOSITIONS

Regresar Medical, Inc., ...

1. A method for limiting a dissipation of a neurotoxin from an injection site, the method comprising:a) applying at least one electrode producing a repellant electric field to a skin surface around the injection site, wherein said at least one electrode does not penetrate the skin, thereby producing the repellant electric field across the intact skin surface where dissipation is to be limited, wherein said repellant electric field comprises a negative charge if an isoelectric point of the neurotoxin is greater than pH 7.4, and wherein said repellant electric field comprises a positive charge if the isoelectric point of the neurotoxin is less than pH 7.4; and applying at least another electrode producing an attractive electric field to the skin surface at the injection site, wherein said at least another electrode does not penetrate the skin, thereby producing the attractive field across the intact skin surface, wherein said attractive electric field comprises a positive charge if said isoelectric point is greater than pH 7.4, and wherein said attractive electric field comprises a negative charge if said isoelectric point is less than pH 7.4; and
b) injecting the neurotoxin; wherein the produced attractive and repellant electric fields limit the dissipation of the neurotoxin.

US Pat. No. 10,987,506

SYSTEM AND METHOD FOR OMNI-DIRECTIONAL BIPOLAR STIMULATION OF NERVE TISSUE OF A PATIENT VIA A SURGICAL TOOL

Medtronic X omed, Inc., ...

1. A modular stimulation module comprising:a first plurality of connecting elements configured to connect to a second plurality of connecting elements on a surgical tool, wherein the first plurality of connecting elements comprise a first connecting element and a second connecting element;
a control module configured to (i) generate a control signal, and (ii) stimulate nerve tissue of a patient by generating a first pulse and a second pulse, wherein the second pulse is generated subsequent to the first pulse;
a bipolar stimulation module configured to, based on the first pulse and the second pulse, generate a plurality of monophasic stimulation pulses, wherein the bipolar stimulation module is configured to output the plurality of monophasic stimulation pulses to a plurality of contacting elements on the tool via the first plurality of connecting elements and the second plurality of connecting elements, wherein the plurality of monophasic stimulation pulses comprise a third pulse and a fourth pulse;
a switching module is configured to, based on the control signal and the plurality of monophasic stimulation pulses, output (i) the third pulse on the first connecting element, and (ii) the fourth pulse on the second connecting element; and
an external housing that houses the modular stimulation module, the external housing configured to be disposed on and carried and supported by the tool.

US Pat. No. 10,987,505

INFUSION PUMP ASSEMBLY

DEKA Products Limited Par...

1. A wearable infusion pump assembly comprising:a disposable housing portion;
a reusable housing portion comprising:
a locking ring assembly of the reusable housing portion; and
a spring actuated tab assembly operably coupled with the locking ring assembly;
a connector, the connector comprising:
a body portion comprising:
an indent configured to interact with the spring actuated tab assembly;
a plug portion located on the body portion, the plug portion comprising a fluid path and configured to be inserted into an exit of the disposable housing portion of the wearable infusion pump assembly;
a tubing, wherein the plug portion is overmolded onto a first end of the tubing, and wherein the first end of the tubing fluidly connected to the plug fluid path;
a catch feature located on a first end of the body portion and configured to interact with the disposable housing portion of the wearable infusion pump assembly; and
a latching feature located on a second end of the body portion, the latching feature configured to interact and lock onto the disposable housing portion of the wearable infusion pump assembly.

US Pat. No. 10,987,504

DISPOSABLE TATTOO NEEDLE CARTRIDGE

1. A disposable tattoo needle cartridge for connecting to a tattoo machine drive unit, the tattoo needle cartridge comprising:a cartridge housing;
a needle assembly comprising a needle driver connector and at least one needle, the needle driver connector being connectable to a needle driver of the tattoo machine drive unit for receiving a reciprocating motion, the needle assembly being slidingly arranged in the tattoo needle cartridge to allow the reciprocating motion along a reciprocation axis,
wherein the cartridge housing has a front end portion provided with a needle nozzle for allowing the at least one needle to reciprocatingly protrude from the tattoo needle cartridge, and a rear end portion configured to be connected to the tattoo machine drive unit, the tattoo needle cartridge being characterized in that the needle driver connector comprises a needle assembly magnet for connecting to a mating drive magnet of the needle driver in a contact-less manner in a radial, with respect to the reciprocation axis, connection direction; and
a releasable needle assembly retainer for retaining the needle assembly at a retracted retain position in which the at least one needle does not protrude from the needle nozzle,
wherein the needle assembly upon release of the needle assembly retainer is movable from the retracted retain position to an advanced operating position at which the at least one needle is free to reciprocate without engaging with the needle assembly retainer.

US Pat. No. 10,987,500

NANOCHANNELED DEVICE WITH ELECTRODES AND RELATED METHODS

THE BOARD OF REGENTS OF T...

1. A nanochannel delivery device comprising:a plurality of inlet microchannels;
a first electrode;
a second electrode;
a plurality of nanochannels; and
a plurality of outlet microchannels, wherein:
each inlet microchannel is in direct fluid communication with an outlet microchannel via a single nanochannel;
the single nanochannel is perpendicular to the inlet microchannel and the outlet microchannel with which it is in direct fluid communication; and
the first electrode is directly coupled to a first surface of the nanochannel delivery device.

US Pat. No. 10,987,499

SWALLOWABLE DRUG DELIVERY DEVICE AND METHOD OF DELIVERY

Rani Therapeutics, LLC, ...

1. A swallowable device for delivering a therapeutic agent preparation into an intestinal wall of a patient's intestinal tract, the device comprising:a swallowable capsule sized to pass through the intestinal tract;
a reservoir disposed in the capsule, the reservoir containing the therapeutic agent preparation comprising a therapeutic agent;
a needle fluidically coupled to the reservoir; the needle having a lumen and engagable with the intestinal wall;
a release element operably coupled to at least one of the reservoir or the needle, the release element configured to cause release of the therapeutic agent preparation from the reservoir through the lumen and into the intestinal wall, responsive to a condition in the small intestine; and
an actuator coupled to the release element, the actuator configured to apply force to the reservoir to drive the therapeutic agent preparation from the reservoir through the lumen and into the intestinal wall,
wherein the actuator comprises an expandable member disposed within the capsule in a partially non-expanded shape, the expandable member including a first portion and a second portion, the first portion including a liquid, the second portion including a reactant configured to react with the liquid to expand the expandable member,
wherein the first and second portions of the expandable member are separated by a separation valve which is configured to degrade upon exposure to a selected pH in the small intestine, and
wherein the expandable member is configured to expand to apply force to the reservoir to drive the therapeutic agent preparation therefrom in response to the liquid from the first portion mixing with the reactant in the second portion.

US Pat. No. 10,987,497

BALLOON CATHETER WITH TACTILE FEEDBACK FEATURES AND REINFORCED LUMEN

Acclarent, Inc., Irvine,...

1. A dilation apparatus comprising:(a) a hollow elongated shaft comprising:
(i) a proximal end,
(ii) a first distal end,
(iii) a first lumen extending from the proximal end to the first distal end, and
(iv) a second lumen extending from the proximal end to a second distal end, wherein the second distal end of the second lumen is proximal in relation to the first distal end;
(b) a dilation balloon, wherein the dilation balloon comprises a proximal end and a distal end, wherein the dilation balloon encompasses the second distal end of the second lumen such that the dilation balloon defines an interior in fluid communication with the second lumen; and
(c) a standoff member, wherein a distal portion of the standoff member is positioned within the interior of the dilation balloon, wherein the distal portion of the standoff member is distal to the second distal end of the second lumen, wherein the standoff member is configured to maintain a pathway for fluid communication between the interior of the dilation balloon and the second lumen, wherein the standoff member includes a a collar fitted about an exterior portion of the hollow elongated shaft.

US Pat. No. 10,987,495

INFLATABLE MEDICAL BALLOON WITH VARIABLE PROFILE

C.R. BARD, INC., Tempe, ...

1. An apparatus for performing a medical procedure, comprising:a balloon having a plurality of inflatable chambers; and
solids sealed within each of the plurality of inflatable chambers.

US Pat. No. 10,987,491

ROBOTIC CATHETER SYSTEM

Corindus, Inc., Waltham,...

1. A robotic catheter system, the system comprising:a cassette including a housing, a first pair of engagement surfaces, and a second pair of engagement surfaces;
the housing including a front end, a rear end, a sidewall, a first channel, and a second channel;
the first pair of engagement surfaces arranged to contact a guide wire with pressure such that when the engagement surfaces are driven, axial movement is imparted to the guide wire;
wherein the guide wire extends along the first channel, through the rear end of the housing, and through the front end of the housing;
the second pair of engagement surfaces arranged to contact a catheter with pressure such that when the engagement surfaces are driven, axial movement is imparted to the catheter;
wherein the catheter device extends along the second channel, the second channel arranged at an angle with respect to the first channel; and
a motor drive base comprising one or more drive motors located in the motor drive base.

US Pat. No. 10,987,489

STEERABLE GUIDE WIRE AND CATHETER WITH SHAPE CHANGE IN-SITU

Coraflo Ltd., Lausanne (...

1. A device, comprising:a guide wire having a distal end, a hollow interior, and an anchoring mechanism positioned proximate to the distal end of the guide wire; and
a core wire configured to be slidably inserted into the hollow interior of the guide wire and, upon insertion, configured to actuate the anchoring mechanism to anchor the guide wire at an anchoring location;
wherein
the anchoring mechanism includes at least one steering mechanism for at least one of: dynamically moving, steering, positioning, stabilization, and anchoring of the guide wire to at least the anchoring location;
the steering mechanism includes at least one nozzle configured to provide a conduit between the hollow interior of the guide wire and an exterior of the guide wire;
the at least one nozzle is configured to be actuated using at least one of: the core wire and a pressure applied from the hollow interior of the guide wire, wherein the pressure is applied using at least one substance;
upon actuation, the at least one nozzle is configured to expunge the at least one substance from the hollow interior of the guide wire to perform at least one of: movement, steering, positioning, stabilization, and anchoring of the guide wire;
the at least one substance includes at least one of the following: a fluid substance, a gaseous substance, an amorphous substance, a solid substance, and any combination thereof;
the guide wire includes a tip at the distal end of the guide wire;
the distal end of the core wire is configured to be coupled to at least one of the distal end of the guide wire and the tip of the guide wire.

US Pat. No. 10,987,488

VESSEL CANNULATION DEVICE AND METHOD OF USE

TRAUMATEK SOLUTIONS, B.V....

1. An automatic vessel cannulation device comprising:a housing having a distal end with a distal tip and a proximal end;
a lumen passing through the distal end and the proximal end;
a needle at the distal tip of the housing, wherein the needle having a needle tip;
a sensor operably coupled to the lumen, wherein the sensor being configured to detect a combination of physiologic parameters at the needle tip; and
a blunting device advancing member configured to advance a blunting device, wherein the blunting device advancing member is operably coupled to the sensor,
wherein the blunting device advancing member is configured to automatically advance the blunting device when the sensor detects that the combination of physiologic parameters are within a pre-determined range.

US Pat. No. 10,987,487

GRIPPER SLEEVE FOR URINARY CATHETER

Cure Medical LLC, Newpor...

12. A gripping sleeve for handling a urinary catheter, comprising:a pair of flexible flat sheets of material having textured inner or outer surfaces that each have proximal and distal ends defining a longitudinal axis therebetween and are bonded together at longitudinal edges to form a sleeve which may be expanded into a tubular shape sized to loosely receive a urinary catheter, wherein the distal ends of the sheets of material are offset with the distal end of a first sheet terminating shorter than the distal end of a second sheet, the sleeve being assembled around the urinary catheter to assist a user in handling the urinary catheter.

US Pat. No. 10,987,485

INSERTION DEVICE WITH SAFETY LOCK

ROCHE DIABETES CARE, INC....

1. An insertion device for inserting an analyte sensor into a body tissue, the insertion device comprising:a casing containing an insertion needle holder and a drive mechanism for driving the insertion needle holder in a longitudinal direction, the drive mechanism comprising at least one actuator for actuating the drive mechanism, wherein the drive mechanism comprises a rotor adapted to transform an actuation motion of the at least one actuator into a motion of the insertion needle holder in the longitudinal direction,
wherein the insertion device further comprises at least one safety lock including at least one operation element extending outside the casing and being operable to bring the at least one safety lock from a locked position into an unlocked position, the at least one operation element having a first position in which the at least one safety lock is locked and a second position in which the at least one safety lock is unlocked, the at least one operation element having a handling portion outside the casing and adapted to be operated by hand,
wherein the at least one safety lock, in the locked position, is adapted to at least partially block a rotation of the rotor and wherein the at least one safety lock, in the unlocked position, is adapted to permit the rotation of the rotor, and
wherein the handling portion is operable by hand outside the casing.

US Pat. No. 10,987,484

BABY MONITOR SYSTEM SOUND AND LIGHT DELIVERY BASED ON VITALS

SYNERGEN Technology Labs,...

1. A baby monitor system comprising:a memory; and
a processor coupled to the memory and configured to:
obtain a sleep schedule of a baby;
obtain vitals of the baby, wherein the vitals are based on pulse oximetry;
transmit, when the sleep schedule indicates that the baby is to begin sleep, a first electrical signal to cause an action, wherein the action is an emission of a first sound or a first light;
make, based on the vitals and after transmitting the first electrical signal, a first determination that the baby has fallen asleep;
transmit, in response to the first determination, a second electrical signal to adjust the action;
make, based on the vitals and after transmitting the second electrical signal, a second determination that the baby has reached a predetermined state of sleep;
transmit, in response to the second determination, a third electrical signal to further adjust or cancel the action;
make a third determination that the baby has prematurely awoken;
cause, in response to the third determination, the first sound to emit and a volume of the first sound to increase until the volume is a first predetermined volume or until the baby falls asleep again;
make a fourth determination that the baby has fallen asleep again; and
cause, in response to the fourth determination, the volume to decrease until the volume is a second predetermined volume or until the baby reaches the predetermined state again.

US Pat. No. 10,987,483

BIOMETRIC FEEDBACK AS AN ADAPTATION TRIGGER FOR ACTIVE NOISE REDUCTION, MASKING, AND BREATHING ENTRAINMENT

BOSE CORPORATION, Framin...

1. A method for regulating a sleep pattern of a subject, comprising:measuring, using a biosignal sensor, a rate of change of at least one biosignal parameter of the subject;
determining, using a processor, a sleep condition of the subject based on the rate of change of the at least one biosignal parameter and sleep data of the subject, the sleep condition associated with a sleep stage that subjects the subject to a noise disturbance level higher than a rapid eye movement (REM) sleep stage associated noise disturbance level, wherein the rate of change is non-zero and less than five units per ten seconds, starting from an onset of the noise disturbance until peaking, wherein the unit comprises beats per minute;
detecting, using an audio sensor, ambient noise in a vicinity of the subject; and
adjusting via an output of at least one speaker, based on the determined sleep condition, at least one sound to regulate the sleep pattern of the subject to offset the noise disturbance level.

US Pat. No. 10,987,482

PATIENT VALVE FOR USE WITH MANUAL RESUSCITATOR

Ventlab, LLC, Grand Rapi...

1. A patient valve used with a manual resuscitator comprising:an upper housing having a first port used in connection with a ventilator bag;
a lower housing having a second port used in connection with a patient mask and a third port for ventilating air from the second port to atmosphere;
a manometer formed integrally within the upper housing;
a valve plate including a first air channel and second air channel both integrally formed with the valve plate, the valve plate positioned between the upper housing and the lower housing such that the first air channel allows air to flow from the first port to the second port and the second air channel is configured to allow air to pressurize the manometer in the upper housing; and
wherein the manometer indicates both inhalation air pressure from the first port and exhalation pressure from the second port through the second air channel in the valve plate.

US Pat. No. 10,987,480

NASAL CANNULA WITHOUT NOSTRIL PRONGS

3B Medical, Inc., Winter...

1. A nasal cannula for an oxygen delivery system, comprising:a tube configured to connect to an oxygen supply; and
a fitting configured to connect to the tube, wherein the fitting includes a discharge port having a first section configured to be situated in an inferior direction relative to a first nostril of a user and a second section configured to be situated in the inferior direction relative to a second nostril of the user, wherein the fitting does not include nostril prongs, wherein the fitting includes a main body portion, a first prong projecting laterally from a first side of the main body portion, and a second prong projecting laterally from a second side of the main body portion, wherein the first prong includes a first port fluidly coupled to the discharge port via a first internal passageway, wherein the second prong includes a second port fluidly coupled to the discharge port via a second internal passageway, wherein the first prong is curved following a radius having a first origin spaced-apart from the first prong in a superior direction and on the first side of the main body portion, and wherein the second prong is curved following a radius having a second origin spaced-apart from the second prong in the superior direction and on the second side of the main body portion,
wherein, when the fitting is positioned to provide gas to the first and second nostrils of the user, the inferior direction is a generally downward direction facing towards a mouth of the user and the superior direction is a generally upward direction opposite the inferior direction,
wherein the first and second ports are spaced-apart from the discharge port in the inferior direction,
wherein the first and second prongs are oriented to resist undesired movement of the fitting, and
wherein the first and second prongs are oriented to keep the discharge port oriented toward the first and second nostrils of the user.

US Pat. No. 10,987,479

POSITIVE-AIR-PRESSURE MACHINE CONDUIT

ResMed Pty Ltd, Bella Vi...

1. A nasal interface assembly for providing respiratory therapy to a patient, the nasal interface assembly comprising:a nasal interface configured to deliver a flow of pressurized breathable gas to the patient's nose;
a pair of flexible conduits configured to support the nasal interface and to deliver the flow of pressurized breathable gas to the nasal interface, wherein the pair of flexible conduits are configured to be fluidly connected to opposing sides of the nasal interface, to extend along opposing sides of the patient's head between the patient's eye and ear on each respective side, and to receive the flow of pressurized breathable gas from a common source;
a shared upper swivel inlet that is configured to be fluidly connected to both flexible conduits of the pair of flexible conduits for supplying the flow of pressurized breathable gas and configured to be retained in a mounting position on a top of the patient's head by the pair of flexible conduits during delivery of the flow of pressurized breathable gas to the nasal interface, wherein the fluid connection between the pair of flexible conduits and the shared upper swivel inlet is T-shaped with the pair of flexible conduits extending at their openings to the fluid connection in opposing directions along a first axis that is transverse to a second axis along which the shared upper swivel inlet extends at the fluid connection, wherein the shared upper swivel inlet includes one or more swivel components that are rotatable about the second axis; and
a rear strap configured to extend between the pair of flexible conduits and around only a portion of a circumference of the patient's head that includes a back of the patient's head, wherein the rear strap is configured to connect the pair of flexible conduits at fixed locations along the length of the pair of flexible conduits that, during delivery of the flow of pressurized breathable gas to the nasal interface, are between (i) the shared upper swivel inlet and (ii) an axial plane at a top of the patient's ears,
wherein:
the pair of flexible conduits include a central portion that connects the pair of flexible conduits and from which the pair of flexible conduits extend,
the pair of flexible conduits are fluidly connected to the shared upper swivel inlet at the central portion,
the central portion, at its fluid connection to the swivel inlet, is wider than adjacent portions of the pair of flexible conduits that are adjacent and connected to the central portion, the adjacent portions of the pair of flexible conduits being configured to be retained on top of the patient's head in the mounting position,
during delivery of the flow of pressurized breathable gas to the nasal interface, the central portion and the adjacent portions contact the top of the patient's head such that an area of contact for the central portion is wider along a sagittal plane than areas of contact for the adjacent portions,
the pair of flexible conduits maintain the nasal interface in an operative position to deliver the flow of pressurized breathable gas to the patient's nose, and
wherein the nasal interface assembly does not include additional securement straps beyond the pair of flexible conduits and the rear strap.

US Pat. No. 10,987,478

POSITIVE-AIR-PRESSURE MACHINE CONDUIT

ResMed Pty Ltd, Bella Vi...

1. A nasal interface assembly for providing respiratory therapy to a patient, the nasal interface assembly comprising:a nasal interface configured to deliver a flow of pressurized breathable gas to the patient's nose;
a pair of flexible conduits configured to support the nasal interface and to deliver the flow of pressurized breathable gas to the nasal interface, wherein the pair of flexible conduits are configured to be fluidly connected to opposing sides of the nasal interface, to extend along opposing sides of the patient's head between the patient's eye and ear on each respective side, and to be both fluidly connected to a shared inlet through which the flow of pressurized breathable gas is received into the pair of flexible conduits, the shared inlet being spaced apart from the nasal interface and retained in a mounting position on a top of the patient's head by the pair of flexible conduits during delivery of the flow of pressurized breathable gas to the nasal interface; and
a headgear strap that is configured to extend between the pair of flexible conduits and around only a portion of a circumference of the patient's head including a back of the patient's head, wherein the headgear strap includes: a first end connected to a first flexible conduit of the pair of flexible conduits at a first junction along the first flexible conduit, and a second end connected to a second flexible conduit of the pair of flexible conduits at a second junction along the second flexible conduit such that, during delivery of the flow of pressurized breathable gas to the nasal interface, the first and second junctions are positioned at fixed locations along the pair of flexible conduits between the shared inlet on the top of the patient's head and an axial plane at a top of the patient's ears,
wherein the nasal interface assembly does not include additional securement straps beyond the pair of flexible conduits and the headgear strap.

US Pat. No. 10,987,477

RESPIRATORY APPARATUS

ResMed Pty Ltd

1. A foam cushion assembly for a patient interface for providing a pressurised air to a user's airway, the foam cushion assembly comprising:a foam cushion portion configured to, in use, seal around portion of the user's nose; and
a flexible support portion extending along a periphery of the foam cushion portion so as to support the foam cushion portion,
wherein the foam cushion portion has a trapezium cross sectional shape in at least a side of nose region and comprises:
(a) a sealing surface including at least a portion thereof at a first side of the trapezium cross sectional shape, the at least a portion of the sealing surface including a radially flat region for user facial contact at the first side, and (b) a fixing surface side of the trapezium cross sectional shape, the fixing surface side being opposite to the first side and comprising a planar surface for adhering to a surface of the flexible support portion,
wherein the sealing surface has a three-dimensional surface contour arranged so that the radially flat region in at least a portion of the sealing surface's periphery is inwardly inclined, with respect to a mid-contact plane of the patient interface, for embracing and conforming to a shape of the user's face in use,
wherein the sealing surface includes a portion for sealing above a pronasale portion of the user's nose in use,
wherein the radially flat region is in both of a side of mouth region and a side of nose region,
wherein the three-dimensional surface contour is radially flat about the sealing surface's periphery in both side of mouth regions, both side of nose regions and a bottom region,
wherein the least a portion of the sealing surface includes a planar surface region, wherein the three-dimensional surface contour is arranged so that the planar surface region in the at least a portion of the sealing surface's periphery is inwardly inclined, with respect to the mid-contact plane of the patient interface, for embracing and conforming to the shape of the user's face in use, and
wherein the foam cushion assembly is arranged to seal around a portion of the user's mouth in use and wherein the three-dimensional surface contour comprises side of mouth planar regions.

US Pat. No. 10,987,476

ANESTHESIA GAS DELIVERY AND MONITORING SYSTEM

H. Lee Moffitt Cancer Cen...

1. A gas delivery and monitoring apparatus, comprising:(a) a support member having a longitudinal axis, a proximal end, and a distal end opposite and spaced apart from the proximal end;
(b) a bite block sized to be disposed within a mouth of a subject between at least one tooth of an upper jaw of the subject and at least one tooth of a lower jaw of the subject, the bite block having a proximal end and a distal end opposite and spaced apart from the proximal end,
(c) a first elongated conduit defining an exhalation capture flow path extending from a capture inlet at the distal end of the bite block and terminating in an outlet port;
(d) a second elongated conduit defining a gas delivery flow path extending from an inlet port into the bite block, and terminating in a gas delivery port at the distal end of the bite block such that both the gas delivery port and capture inlet are located in the mouth of the subject when the bite block is inserted in the mouth of the subject during use; and
(e) a bridge extending between the proximal end of the bite block and the proximal end of the support member, wherein the bridge has a curvature that extends the bridge around a corner of the mouth of the subject when the bite block is disposed within the mouth of the subject between the at least one tooth of the upper jaw of the subject and the at least one tooth of the lower jaw of the subject such that the distal end of the support member and the distal end of the bite block are simultaneously positioned on opposite sides of a cheek of the subject and posterior to the corner of the mouth of the subject,
wherein a portion of the first elongated conduit between the bite block and the support member and a portion of the second elongated conduit between the bite block and the support member follows the curvature of the bridge.

US Pat. No. 10,987,474

RETROFIT AEROSOL DELIVERY SYSTEM AND METHOD

Stamford Devices Ltd., D...

1. A retrofit aerosol delivery system for existing respiration systems, comprising:a conduit adapter defining an open interior, the conduit adapter being configured to be fluidly coupled between an artificial respiration system and a delivery lumen that is configured to interface with a patient's airway;
an aerosol generator coupled with the conduit adapter such that an output of the aerosol generator is in fluid communication with the open interior of the conduit adapter, the aerosol generator being configured to aerosolize a liquid medicament for delivery to the patient's airway via the open interior of the conduit adapter;
a flow sensor coupled with the open interior of the conduit adapter and configured to generate a signal during ventilation; and
a controller coupled to the aerosol generator and the flow sensor, wherein the controller:
receives the signal from the flow sensor;
predicts a start of inhalation;
causes liquid medicament to be preloaded onto a vibratable member of the aerosol generator beginning at least 1% before a start of a predicted inhalation as measured by a duration of a predicted-inhalation; and
controls the aerosol generator to start aerosolizing the liquid medicament before and/or during portions of the breath.

US Pat. No. 10,987,472

DOSE DETECTION FOR A MEDICATION DELIVERY DEVICE

Eli Lilly and Company, I...

1. A dose delivery measurement module for use with a medication delivery device having an actuator, a dose setting member, a magnetic ring with one or more dipoles, the magnetic ring fixed rotationally with the dose setting member that rotates during dose setting and/or dose delivery, the module comprising:a module body adapted to be engageable with said actuator of said medication delivery device;
a plurality of magnetic sensing elements attached to said module body, the magnetic sensing elements spaced equi-radially apart to define a ring pattern; and
a controller operably connected to the magnetic sensing elements, the magnetic sensing elements configured to detect an angular position and/or a rotational movement of the magnetic ring relative to the magnetic sensing elements in order to generate a signal representative of the detected angular position and/or rotational movement, wherein the controller is configured to receive the signal in order to determine data indicative of an amount of dose delivered based on the signal,
wherein, when the module body is attached to the actuator, the magnetic sensing elements are positioned axially over said magnetic ring, and the magnetic sensing elements are arranged in an overlapping position relative to an outer circumference of the magnetic ring,
wherein the actuator of said medication delivery device comprises a rotatable dose skirt and a push dose button positioned proximal to said rotatable dose skirt, and wherein a portion of the module body is engageable with at least one of the push dose button and the rotatable dose skirt.

US Pat. No. 10,987,471

INJECTION DEVICE DRIVE WITH TWO GEAR PATTERNS

Eli Lilly and Company, I...

1. An injection device for use with a medicament cartridge, the injection device comprising:a drive member having an elongate shaft and defining an axis and having first and second gear patterns, wherein the first and second gear patterns are fixed relative to each other and formed along an exterior of the shaft that is common for the first and second gear patterns, the drive member being rotatable about the axis and translatable in first and second opposing axial directions;
a plunger having an elongate stem, the plunger being couplable with the cartridge to expel medicament from the cartridge when the plunger is translated in an advancing direction;
a dosage indicator, the dosage indicator being moveable to indicate a set dosage;
a first gearing arrangement operably coupling the first gear pattern with the plunger wherein in response to a rotation of the drive member in a first rotational direction the drive member is translated in the first axial direction without movement of the plunger, and wherein in response to a translation of the drive member in the second axial direction the plunger is driven in the advancing direction; and
a second gearing arrangement operably coupling the second gear pattern with the dosage indicator, wherein in response to the drive member being translated in the first axial direction the second gearing arrangement is configured to move the dosage indicator to indicate an increase in the set dosage.

US Pat. No. 10,987,469

ROTATABLE FINGER LOOP FOR SYRINGE, SYRINGE CONFIGURED TO RECEIVE THE ROTATABLE FINGER LOOP AND ASSOCIATED METHODS

PMT Partners, LLC, Park ...

7. A medical system, comprising:a syringe with a barrel that includes:
a collar at or near a proximal end of the barrel, the collar including a distally facing surface outside of an outer circumference of a remainder of the barrel; and
a plurality of distal retention elements protruding from intermediate locations around a circumference of the barrel, each distal retention element tapering distally toward the outer circumference of the remainder of the barrel from a substantially planar proximally facing surface to a more distal location along a length of the barrel,
an interior of the barrel being capable of receiving fluid and retaining the fluid; and
a handle provided separately from the barrel and capable of assembly directly on an outer surface of the barrel, between the collar and the plurality of distal retention elements, the handle including a body capable of free rotation around a circumference of the barrel when the handle is assembled with the barrel and while forcing a plunger of the syringe distally into the barrel to expel fluid from the barrel and/or while forcing the plunger proximally out of the barrel to draw fluid into the barrel, the handle further including a plurality of tabs at locations around the body that flexibly engage the plurality of distal retention elements of the barrel of the syringe; and
an elongated medical instrument coupled to a distal end of the barrel in such a way that rotation of the barrel will rotate the elongated medical instrument, a lumen of the elongated medical instrument in fluid communication with the interior of the barrel.

US Pat. No. 10,987,467

CANNULA DEPLOYMENT MECHANISM

BECTON, DICKINSON AND COM...

1. A patch pump comprising:a reservoir;
a pump;
a cannula insertion device comprising a yoke having a first channel and a second channel, a carriage carrying a catheter, and a linkage linking the yoke to the carriage, the cannula insertion device powered by a torsion spring for inserting an introducer needle and the catheter into an infusion site and for retracting the introducer needle while the catheter remains inserted into the infusion site;
wherein the first channel and the second channel comprise an enlarged opening where the first channel and the second channel overlap;
wherein infusate from the reservoir is pumped by the pump into the infusion site after the catheter is inserted into the infusion site.

US Pat. No. 10,987,466

NEEDLE CONTROL AND DRUG MIXING SYSTEMS FOR A FLUID DELIVERY DEVICE

1. A fluid delivery device comprising:a housing having a base including a bottom surface and a cartridge receiver configured to receive a cartridge, the cartridge having a fluid reservoir and a septum configured to be generally perpendicular to the bottom surface when the cartridge is engaged with the cartridge receiver;
a needle assembly having a needle, the needle having a delivery end, a fluid coupling end, and a central portion located between the delivery end and the fluid coupling end, the fluid coupling end being fluidly disengaged from the fluid reservoir in an initial position, the fluid coupling end being fluidly coupled with the fluid reservoir in a primed position, the needle assembly being configured to translate laterally relative to the base from the initial position to the primed position, the needle assembly having one or more snap features; and
a channel for receiving the cartridge,
wherein the cartridge receiver has a locked position in which the needle assembly is retained in the initial position and an unlocked position in which the needle assembly is able to translate from the initial position to the primed position,
wherein the cartridge receiver is configured to be in the locked position when the cartridge receiver is not engaged with the cartridge and configured to be in the unlocked position when the cartridge receiver is engaged with the cartridge,
wherein the cartridge receiver, when in the locked position, is configured to be raised vertically from the base and block the one or more snap features from moving towards the channel, and
wherein the cartridge receiver is configured to be depressed out of alignment with the one or more snap features on placement of a cartridge in the channel, allowing the needle assembly to be pushed toward the cartridge.

US Pat. No. 10,987,464

PEN CAP FOR INSULIN INJECTION PENS AND ASSOCIATED METHODS AND SYSTEMS

Bigfoot Biomedical, Inc.,...

1. A pen cap for a manual insulin delivery device, comprising:a wireless communication interface configured to receive glucose measurement data from a glucose sensor system;
at least one detection circuit configured to detect one or more cappings and one or more decappings of the pen cap from the manual insulin delivery device;
at least one user interface configured to present one or more of therapy relevant information, therapy recommendations, and timing information associated with detected cappings or detected decappings of the pen cap; and
a processor and a memory, the memory comprising:
a data segment configured to store one or more of at least one user-specific dosage parameter and a recommended dose; and
a code segment configured to store instructions that, when executed by the processor, cause the processor to:
determine that a replacement cap has been continuously capped on the manual insulin delivery device for at least a threshold period of time; and
cause the at least one user interface to display a recommended correction dose of insulin responsive to the determination that the replacement cap has been capped on the manual insulin delivery device for at least the threshold period of time.

US Pat. No. 10,987,463

HANDPIECE FOR CLEANING WOUNDS

MEDAXIS AG, Baar (CH)

1. A handpiece unit for cleansing wounds with a fluid jet, said handpiece unit comprisinga fluid line being connected to a handpiece with a main body, the main body having a front end and a rear end,
the fluid line being connected to the rear end of the main body, the fluid line ensuring a supply of pressurized fluid to the main body, the front end of the main body having a front face with an emergence opening for the emergence of a fluid jet of the pressurized fluid supplied by the fluid line, the handpiece provided with a nozzle arranged in the front end, the nozzle forming the emergence opening, a position of the nozzle being defined by a front abutment, the nozzle having a nozzle channel arranged centrally in the nozzle, wherein the design of the nozzle channel defines an emergence geometry of the fluid jet, the fluid jet emerging from the emergence opening being a microfluidic jet with a diameter of 0.05 mm to 0.15 mm,
an adapter which is releasable connectable to the front end of the handpiece, the adapter surrounding and receiving the front end of the main body and surrounding the emergence opening,
a porous body which is connected to the adapter, the porous body protruding beyond the emergence opening in a direction of a flow of the fluid jet emerging from the emergence opening,
wherein the porous body defines a longitudinal central axis and wherein the direction of the fluid jet flowing out of the emergence opening extends inclined relative to the longitudinal central axis, the porous body having a through-opening, the through-opening forming a space through which the fluid jet flowing out of the emergence opening can pass unimpeded,
wherein the porous body has a contact area for contact with a wound to be cleaned, which contact area extends perpendicularly with respect to the longitudinal central axis and which contact area extends at an angle other than 90 degrees with respect to the direction of the flow of the fluid jet emerging from the emergence opening,
wherein the fluid jet flowing out of the emergence opening enters the through-opening of the porous body, wherein the fluid jet reaches an end of the through-opening, the end being surrounded by the contact area, wherein the fluid jet reaching the end of the through-opening reaches the longitudinal central axis, and
wherein the adapter is transparent, permitting view of the wound to be cleaned.

US Pat. No. 10,987,462

ACOUSTOPHORESIS DEVICE HAVING IMPROVED DIMENSIONS

The Charles Stark Draper ...

1. A device, comprising:an acoustic transducer;
a separation channel configured to carry a fluid and defined within a first thermoplastic substrate forming a first sidewall, a second sidewall, and a roof of the separation channel, the first thermoplastic substrate coupled with a second thermoplastic substrate forming a floor of the separation channel, the floor configured to couple with the acoustic transducer, wherein:
a first width of the separation channel is selected to be between 0.2 and 0.3 times an acoustic wavelength of a first acoustic wave imparted in the fluid by the acoustic transducer;
the first sidewall and the second sidewall each have a second width selected based on the first width of the separation channel, a velocity of the first acoustic wave imparted in the fluid, and a velocity of a second acoustic wave imparted on the first thermoplastic substrate; and
a first inlet defined within the first thermoplastic substrate to introduce the fluid into a proximal end portion of the separation channel;
a first outlet defined within the first thermoplastic substrate, the first outlet positioned at a downstream portion of the separation channel substantially along a longitudinal axis of the separation channel; and
a second outlet defined within the first thermoplastic substrate, the second outlet positioned at the downstream portion positioned adjacent to a first sidewall of the separation channel.

US Pat. No. 10,987,460

METHODS AND SYSTEMS OF GENERATING RAPIDLY VARYING PRESSURE AMPLITUDES IN FLUIDIC CIRCUITS IN A DIALYSIS TREATMENT SYSTEM

Fresenius Medical Care Ho...

1. A method for providing increasing clearance levels of blood toxins comprising:providing a portable dialysis system comprising:
a manifold, comprising a plurality of blood and dialysate circuits;
at least one tube segment in fluid communication with at least one of the blood and dialysate circuits;
a pump for pumping a fluid through the at least one tube segment and at least one of the plurality of blood and dialysate circuits; and
operating the pump to apply a force to the at least one tube segment to generate fluid flow through the at least one tube segment, wherein the pump is configured to generate the fluid flow with a pressure profile that varies between a positive pressure and a negative pressure within a predetermined period and wherein the fluid flow continues flowing in a same direction while the pressure profile varies between the positive pressure and the negative pressure.

US Pat. No. 10,987,459

METHOD AND SYSTEM FOR THE CALIBRATION OF DEVICES FOR IDENTIFYING BLOOD OR BLOOD CONSTITUENTS IN A FLUID

Fresenius Medical Care De...

1. A method for calibrating a device for detecting blood or blood components in a liquid in a dialysate line, the device comprising a light transmitter, a light receiver, and an evaluation unit that receives a signal from the light receiver and is designed such that blood or blood components in the liquid in the dialysate line are detected on a basis of an intensity of radiation passing through the liquid in the dialysate line,wherein the calibrating of the device for detecting blood or blood components occurs without exposure of the device to a blood-containing calibration solution, the calibrating uses an absorption standard and a scattering standard, the absorption standard has predetermined optical properties in relation to an absorption of light in blood, the absorption standard is arranged in a beam path between the light transmitter and the light receiver, the scattering standard has predetermined optical properties in relation to a scattering of the light in blood, and the scattering standard is arranged in the beam path between the light transmitter and the light receiver.

US Pat. No. 10,987,458

METHOD OF USING A MEDICAL FLUID GENERATING MACHINE

Fresenius Medical Care Ho...

1. A method of preparing dialysate or saline or hypotonic saline with a medical fluid generating machine, the method comprising:receiving, at the medical fluid generating machine, a container to be filled with the dialysate or saline or hypotonic saline;
receiving, at a processor, instructions to prepare the dialysate or saline or hypotonic saline, the instructions including an identification of a medical fluid type from among dialysate or saline or hypotonic saline and a desired volume of the dialysate or saline or hypotonic saline;
preparing the dialysate or saline or hypotonic saline according to the received instructions;
testing the prepared dialysate or saline or hypotonic saline to ensure that one or more characteristics of the prepared dialysate or saline or hypotonic saline is within an acceptable range;
filling the container with the prepared dialysate or saline or hypotonic saline; and
labelling the container with information about the dialysate or saline or hypotonic saline, the information including the identification of the medical fluid type within the filled container, and an expiration date of the dialysate or saline or hypotonic saline.

US Pat. No. 10,987,456

DEVICES FOR USE IN EXTRACTING PERCUTANEOUS VENTRICULAR ASSIST DEVICES

Synecor LLC, Durham, NC ...

1. A method of extracting a pVAD device implanted in a heart of patient, the pVAD positioned with a distal portion in an aorta of the heart and a drive line extending across an inter-atrial septum and out of the body via a superior vessel of the venous vasculature, the method comprising:engaging a distal part of the pVAD device in the aorta of a patient using an engaging instrument introduced into a femoral artery and through the descending aorta;
introducing a cutter into the venous vasculature superior to heart and advancing the cutter to a position adjacent to an inter-atrial septum;
cutting the pVAD drive line adjacent to the inter-atrial septum using the cutter, while the distal part of the pVAD device is engaged in the aorta by the engaging instrument;
withdrawing a first portion of the pVAD from the body via the venous vasculature; and
withdrawing a second portion of the pVAD from the body via the femoral artery.

US Pat. No. 10,987,455

BREAST PUMP, METHOD AND COMPUTER PROGRAM

KONINKLIJKE PHILIPS N.V.,...

1. A breast pump for extracting milk from a female breast comprising:a housing, including a vacuum release valve integrated in the housing,
an expression kit,
a container connected to the expression kit, and
a vacuum unit connected to the expression kit via an air-ducting connection,
wherein a system air volume is defined as the sum of the air volumes of the expression kit, the housing, the air-ducting connection, the container, and the vacuum unit,
a vacuum pressure sensor, and
a control unit for receiving a sensor signal of the vacuum pressure sensor and comprising a processor for using the received sensor signal to determine changes in the system air volume in response to changes in vacuum pressure and calculate therefrom a milk volume expressed from the female breast and collected in the container, and
wherein the system air volume is dependent on the milk volume expressed from the female breast and collected in the container.

US Pat. No. 10,987,454

REDUCED-PRESSURE WOUND TREATMENT SYSTEMS AND METHODS EMPLOYING MANIFOLD STRUCTURES

KCI Licensing, Inc., San...

1. A reduced-pressure wound treatment system for treating a tissue site on a patient, the system comprising:a manifold structure configured for disposing proximate the tissue site, the manifold structure configured to deform more in a first direction than in a second direction upon being subjected to a reduced pressure, wherein the first direction and the second direction are substantially coplanar, the manifold structure comprising:
a plurality of spaced longitudinal members, and
at least one shaped projection coupled to at least one of the spaced longitudinal members, the at least one shaped projection comprising a columnar member having a distal end and an enlarged member positioned at the distal end of the columnar member;
a sealing member configured for placing over the tissue site and the manifold structure and operable to form a fluid seal over the tissue site and the manifold structure; and
a reduced-pressure subsystem for delivering reduced pressure to the sealing member.

US Pat. No. 10,987,453

MULTI-WAY VALVE FOR A MEDICAL INSTRUMENT

Gyros Acmi, Inc., Westbo...

1. A medical device comprising:an instrument port;
a suction port in fluid communication with the instrument port;
an irrigation port in selective fluid communication with both the instrument port and the suction port, the irrigation port is configured to be in communication with an irrigation source supplying fluid to the medical device;
an occluder disposed between the irrigation port and both the instrument port and the suction port, the occluder is configured to move between:
a. a first position preventing fluid communication between the irrigation port and both the instrument port and the suction port, while providing fluid communication between the suction port and the instrument port, and
b. a second position allowing fluid communication between the irrigation port and both the instrument port and the suction port, and
a manifold located downstream of the occluder, the manifold including a first aperture in communication with the instrument port and a second aperture that is smaller than the first aperture in communication with the suction port,
wherein, when the occluder is in the second position, at least a first portion of the fluid is configured to move from the irrigation port through the first aperture and to the instrument port and at least a second portion of the fluid is configured to move from the irrigation port through the second aperture and to the suction port, and
wherein movement of the fluid supplied to the medical device at the irrigation port moves the occluder from the first position to the second position.

US Pat. No. 10,987,451

DRUG-COATED BALLOON CATHETERS FOR BODY LUMENS

Urotronic, Inc., Plymout...

1. A drug-coated balloon catheter comprising:an elongated balloon; and
a coating layer overlaying an exterior surface of the balloon, the coating layer comprising
an initial drug load of a therapeutic agent comprising paclitaxel, and
one or more water-soluble additives comprising pentaerythritol ethoxylate (15/4) and pentaerythritol ethoxylate (3/4), wherein a mass ratio of the paclitaxel to the pentaerythritol ethoxylate (15/4) and the pentaerythritol ethoxylate (3/4) is 1:5.5 to 10:1.

US Pat. No. 10,987,450

LYOPHILIZED MOLDABLE IMPLANTS CONTAINING AN OXYSTEROL

Warsaw Orthopedic, Inc., ...

1. A method for making a lyophilized implant, the method comprising mixing a fluid with an implant that has not been lyophilized, the implant comprising an oxysterol in an amount of about 5 wt. % to about 90 wt. %, a biodegradable polymer in an amount from about 0.1 wt. % to about 20 wt. %, and mineral particles in an amount from about 0.1 wt. % to about 75 wt. % based on a total weight of the implant, and subjecting the implant mixed with the fluid to lyophilization to form the lyophilized implant, wherein the oxysterol has a particle size range of about 5 microns to about 100 microns and the oxysterol is in anhydrous form.

US Pat. No. 10,987,449

DECELLULARIZATION METHOD AND SYSTEM AND DECELLULARIZED TISSUE FORMED THEREBY

Clemson University Resear...

1. A method for decellularizing a tissue segment, the tissue segment including a lumen and a tissue wall surrounding the lumen, the tissue wall having an interior surface facing the lumen and an exterior surface that is opposite the interior surface, the method comprising:contacting the interior surface of the tissue wall with a decellularization solution as the decellularization solution passes through the lumen;
pumping the decellularization solution out of the lumen of the tissue segment and into a first flow line;
pumping the decellularization solution out of the first flow line and into a second flow line that is in fluid communication with and downstream of the first flow line;
contacting the exterior surface of the tissue wall with the decellularization solution after the decellularization solution exits the second flow line; wherein the decellularization solution follows a flow path that sequentially exits the lumen of the tissue segment, passes through the first flow line, passes through the second flow line, and enters a decellularization chamber within which the tissue segment is retained to contact the exterior surface of the tissue wall;
establishing a pressure differential across the tissue wall from the interior surface to the exterior surface for a period of time of about 1 minute or more, the pressure differential being from about 15 mmHg to about 150 mmHg; and
following the period of time, decreasing the pressure differential to a lower pressure differential across the tissue wall, the lower pressure differential being about 15 mmHg or less.

US Pat. No. 10,987,446

PORTABLE AIR FRESHENER DEVICE

1. A portable air freshener device, comprising:a solid fragrance material;
a fan;
a fragrance release shutter disposed between the fan and the solid fragrance material, wherein forced air flow due to operation of the fan causes the fragrance release shutter to inhibit air flow to and from the solid fragrance material less when the fan is operating than when it is not operating; and,
a controller that is programmed to control operation of the fan.

US Pat. No. 10,987,444

INTEGRATED FOGGING SYSTEM PROVIDING ATOMIZED SOLUTION TO AN ENCLOSED TREATMENT AREA AND RELATED METHODS

GCMG COMPANIES, LLC, Ovi...

17. A method for disinfecting an enclosed area with an atomized disinfectant fluid, the enclosed area having an access door associated therewith and an electronic door lock actuator to lock and unlock the access door, the system comprising:positioning a fogging device within the enclosed area, the fogging device comprising a housing and an atomizing disinfectant generator carried by the housing and comprising an atomizing nozzle in fluid communication with a disinfectant fluid reservoir, and a compressor coupled to the atomizing nozzle; and
initiating an automated disinfection treatment cycle during which the compressor dispenses atomized disinfectant fluid into the enclosed area via the atomizing nozzle while the access door is locked, and without dispensing atomized disinfectant fluid into the enclosed area while the access door is not locked.

US Pat. No. 10,987,443

CONTAINER STERILIZATION DEVICE AND SYSTEM, ASSEMBLING METHOD THEREOF, AND USE THEREOF

Chio Kang Medical, Inc., ...

1. A container sterilization device, comprising:a sterilization gas supply assembly comprising a chemical feeding pipeline provided with a chemical feeding opening;
a gas circulation assembly comprising a vacuum pump, a gas circulation pipeline provided with a gas charging opening, and a gas extraction pipeline provided with a gas extraction opening; and
a heating and humidification assembly comprising a thermostatic water tank, a steam generator, a first connecting pipeline, and a humidity feeding pipeline, the humidity feeding pipeline being provided with a humidity feeding opening;
wherein the chemical feeding pipeline is at least partially located in the thermostatic water tank;
wherein an end of the gas circulation pipeline that is opposite from the gas charging opening is configured to be in fluid communication with an end of the gas extraction pipeline that is opposite from the gas extraction opening, wherein a joint connecting the gas circulation pipeline with the gas extraction pipeline and a portion of pipelines adjacent to the joint are located in the thermostatic water tank, and wherein the vacuum pump is disposed on the gas extraction pipeline between the gas extraction opening and the thermostatic water tank; and
wherein the first connecting pipeline is configured to provide fluid communication between the thermostatic water tank and the steam generator, and wherein an end of the humidity feeding pipeline that is opposite from the humidity feeding opening is configured to be in fluid communication with the steam generator.

US Pat. No. 10,987,441

DISINFECTING UVC LAMP APPLIANCE

1. A disinfecting lamp appliance comprisinga chassis;
a lamp configured to emit light in an ultraviolet C range of wavelengths, wherein the lamp is supported on the chassis; and
an electrical system for operating the lamp, the electrical system including
a power source,
conductors conducting power from the power source to the lamp, and
a switching arrangement controlling access of power from the power source to the lamp, the switching arrangement including a time delay feature inhibiting illumination of the lamp for a predetermined time interval after the switching arrangement is operated to conduct power to the lamp; wherein
the lamp is movably supported on the chassis, thereby enabling the lamp to emit light in the ultraviolet C range of wavelengths in plural positions relative to the chassis;
the lamp is linear and comprises a proximal end and a distal end, and is pivotally supported on the chassis at the proximal end of the lamp, and the distal end of the lamp can pivot through an arcuate path;
the chassis includes a shield having a longitudinal axis, wherein the lamp is movable to a retracted position partially surrounded by the shield and to plural extended positions wherein the lamp is outside the shield;
the shield has a length and is open along the length to project emitted ultraviolet C light in a radial pattern relative to the longitudinal axis, and the radial pattern extends less than half of a radial pattern that would result from light projection in the absence of the shield;
the disinfecting lamp appliance further comprising a lamp head fixed to the lamp, and wherein the lamp is pivotally anchored at the lamp head to the shield;
the shield includes three sides covering the lamp along the length of the lamp and the longitudinal axis is a first longitudinal axis centrally located within the three sides; and
the lamp head comprises three sides each coincident with one of the three sides of the shield and a second longitudinal axis centrally located within the three sides of the lamp head, whereby in the retracted position, the first longitudinal axis is aligned with the second longitudinal axis, and the three sides of the lamp head appear as extensions of the three sides of the shield.

US Pat. No. 10,987,440

ULTRAVIOLET PATHOGEN DISINFECTION SYSTEM

EnviroProcess Consultants...

1. A pathogen disinfection system, comprising:a base having a selected length;
a pathogen disinfection apparatus including at least one ultraviolet (UV) light source disposed in the base and configured to emit UV light having a mean peak wavelength between 200-280 nanometers in a path substantially normal to the base for substantially the length of the base, the emitted UV light forming a disinfecting light curtain to at least partially inactivate airborne pathogens passing through the disinfecting light curtain, wherein the disinfecting light curtain is configured to separate a breathing zone for a first individual from another individual to at least partially inactivate airborne pathogens passing through the air between the individuals;
a beam shaping mechanism comprising one or more reflectors disposed in the base or a slot defined in the base, wherein the beam shaping mechanism is configured to shape the path of the emitted UV light forming the disinfecting light curtain so that the disinfecting light curtain is confined to a selected width for at least a selected height or distance from the base, wherein the selected width is between a maximum of 0.5-12 inches, and wherein the selected height or distance from the base is between a minimum of 3-10 feet;
a first motion sensor configured to detect when an object or human being is in the UV light path and to send a first signal in response to detecting the object or human being in the UV light path;
a proximity sensor configured to detect when a human being is present within a given distance from the base in a particular direction and to send a second signal in response to detecting such a presence; and
a controller to activate the UV light source in response to receiving the second signal and to deactivate the UV light source in response to receiving the first signal.

US Pat. No. 10,987,439

STERILIZATION METHOD AND STERILIZATION DEVICE

ASAHI KASEI KABUSHIKI KAI...

1. A sterilization method configured to apply ultraviolet light to a sterilization target that is a cap formed by a dented portion and a protruded portion from each of a plurality of light sources each including an LED element, the sterilization method comprising: transferring the sterilization target; positioning the sterilization target; and irradiating the sterilization target with ultraviolet light,wherein, in the positioning, the sterilization target is stopped at a position in which ultraviolet light is emitted from the plurality of light sources; and
wherein, in the irradiating, the sterilization target is irradiated a plurality of times with the ultraviolet light from at least one of the light sources arranged at a position where a maximum irradiation intensity of the ultraviolet light emitted from the light sources is applied to the dented portion of the target.

US Pat. No. 10,987,438

STERILIZING METHOD AND APPARATUS

Turbett Surgical, Inc., ...

1. A filter cartridge for a sterilizing cabinet, the filter cartridge comprising:(a) a first gasket comprising a rigid or flexible beaded edge and defining a hollow center portion; and
(b) a first filter, the first filter comprising (i) a perimeter edge, and (ii) a porous material being affixed to the first gasket, the porous material being able to pass gaseous materials through its surface, wherein the filter cartridge provides sufficient structural integrity to form a sealing interface with a confronting surface of the sterilizing cabinet, and wherein the first gasket is a beaded edge spaced a given distance from the perimeter edge of the first filter.

US Pat. No. 10,987,437

METHOD AND APPARATUS FOR STERILIZING AND DISINFECTING AIR AND SURFACES AND PROTECTING A ZONE FROM EXTERNAL MICROBIAL CONTAMINATION

1. A process for destroying a DNA or RNA of a microorganism on or in a substance or on a surface comprising the steps of:generating photons of a wavelength corresponding to a peak absorption wavelength of proteins, or DNA, or RNA, the wavelength being 222 nm;
directing the photons to a substance or surface to be disinfected, whereby the photons are generated to destroy a plurality of chemical bonds within the proteins, DNA, or RNA of the microorganisms; and
wherein the substance or surface to be disinfected is human or animal tissue.

US Pat. No. 10,987,431

PREPARATION METHOD OF ADIPOSOMES, AND USE THEREOF

INSTITUTE OF BIOPHYSICS, ...

1. A method for preparing adiposomes consisting of neutral lipids and a monolayer phospholipid membrane, the method comprising:a1) vortexing phospholipid and neutral lipids in a buffer to enable a reaction between both, performing centrifugation, and collecting an upper liquid phase;
wherein the adiposomes are obtained by isolation of the upper liquid phase comprising:
a2) performing purification on the upper liquid phase obtained in step a1) twice or more, wherein each purification comprises uniformly mixing the upper liquid phase with the buffer, layering the mixture, performing centrifugation, wherein the parameters of the centrifugation are: 18000-22000 g, for 3-7 min, and collecting an upper liquid phase; and
a3) mixing the upper liquid phase obtained in step a2) with the buffer, layering the mixture, performing centrifugation, wherein the parameters of the centrifugation are: 800-1200 g, for 3-7 min, and collecting a lower liquid phase containing adiposomes, wherein the phospholipid is b1), b2) or b3), wherein:
b1) is 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine;
b2) is 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine and 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine; and
b3) is 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine and 1,2-di-octadecanoyl-sn-glycero-3-phosphocholine;
wherein, in the b2), a mass ratio of 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine and 1,2-di-(9Zoctadecenoyl)-sn-glycero-3-phosphoethanolamine is 1:0.01-2;
wherein, in the b3), a mass ratio of 1,2-di-(9Z-octadecenoyl)-sn-glycero-3-phosphocholine and 1,2-di-octadecanoyl-sn-glycero-3-phosphocholine is 1:0.01-2;
wherein the neutral lipid is c1) or c2), wherein:
c1) is triacylglycerol; and
c2) is triacylglycerol and cholesteryl oleate,
wherein in the c2), a mass ratio of triacylglycerol and cholesterol oleate is 1-5:1; and
d1) wherein the mass ratio of the phospholipid and the neutral lipid is 0.25-3:5.

US Pat. No. 10,987,430

DI-SUBSTITUTED MALEIC AMIDE LINKER FOR ANTIBODY DRUG CONJUGATING AND PREPARATION METHOD AND USE THEREOF

Mabwell (Shanghai) Biosci...

1. A substituted maleamide linker as shown in Formula Ia,
wherein, R is X or ArS-,
X is selected from halogen;
Ar is selected from the group consisting of substituted or unsubstituted C6-C10 aryl and substituted or unsubstituted 5-12 membered heteroaryl;
Ar? is selected from the group consisting of substituted or unsubstituted C6-C10 arylene, and substituted or unsubstituted 5-12 membered heteroarylene; and
L1 is —O(CH2CH2O)n— linked to Ar?, in which n is any integer between 1 and 20.

US Pat. No. 10,987,429

INHIBITOR OF ATP-DEPENDENT CELLULAR REVERSE TRANSPORTERS AND METHOD FOR PRODUCING SAME

Kazan Federal University,...

1. An inhibitor of ATP-dependent cellular reverse transporters of a group of chiral conjugates, the chiral conjugates being oligoetherpolyolic optically active hybrid molecules, the inhibitor being a mixture of polyoxypropylenehexol of formulaand a polyoxypropylene glycol of formulawherein n is from a range of 2 to 6 and wherein m is from a range of 5 to 9.

US Pat. No. 10,987,427

MODIFIED THERAPEUTIC AGENTS AND COMPOSITIONS THEREOF

THE SCRIPPS RESEARCH INST...

1. A lipid conjugate (LC), comprisinga. one or more lipids, the lipids selected from a group consisting of sterols, bile acids, vitamin E, fatty di-acids, fatty acids, fatty amides, fatty amines, fatty alcohols, and derivatives thereof; and
b. a therapeutic agent (TA) comprising an amino acid sequence that is SEQ ID NO: 45;
wherein the one or more lipids are conjugated to the TA via a cysteine residue at the N-terminus of SEQ ID NO: 45.

US Pat. No. 10,987,421

RAMP SIGNAL GENERATOR OF IMAGE SENSOR, AND IMAGE SENSOR INCLUDING SAME

SAMSUNG ELECTRONICS CO., ...

1. A ramp signal generator of an image sensor, the ramp signal generator comprising:a sampling capacitor connected between a power supply voltage and a sampling node, configured to sample a bias voltage transferred through a transferring switch;
a current cell circuit configured to provide a first output node with a first ramping current during a ramping period, in response to a sampled bias voltage of the sampling node and a plurality of switching code pairs;
a current to voltage converter including a first load resistor connected between the first output node and a ground voltage, wherein the first load resistor is configured to convert the first ramping current to a first ramp signal which is ramping during the ramping period; and
a tuning circuit connected between the first output node and the sampling node, the tuning circuit including at least one capacitor configured to couple the sampling node and the first output node, wherein the tuning circuit is configured to adjust a degree of nonlinearity of the first ramp signal in response to a tuning signal.

US Pat. No. 10,987,417

ENGINEERED AND MULTIMERIZED HUMAN IMMUNODEFICIENCY VIRUS ENVELOPE GLYCOPROTEINS AND USES THEREOF

Fred Hutchinson Cancer Re...

1. An engineered and multimerized (e/m) human immunodeficiency virus (HIV) envelope glycoprotein (Env) comprising: (i) mutations, using HXB2 numbering: N460D, N463D, S278R, and G471S; and (ii) removal of the V1 loop and the V2 loop wherein the e/m Env does not include a mutation at residue 276.

US Pat. No. 10,987,408

COMPOSITIONS AND METHODS FOR MODULATING TOLL-LIKE RECEPTOR 2 ACTIVATION

THE CLEVELAND CLINIC FOUN...

1. A method of promoting hair growth of a mammalian subject, comprising:administering to follicle cells of the mammalian subject a therapeutically effective amount of a TLR2 agonist that promotes TLR2 activation and hair growth of the mammalian subject, the TLR2 agonist comprising a carboxyethylpyrrole (CEP) adduct having the following formula:

wherein X is a carrier molecule, the carrier molecule selected from the group consisting of a dipeptide, mouse serum albumin and human serum albumin, and is bound to the amine of the CEP pyrrole or pharmaceutically acceptable salts thereof.

US Pat. No. 10,987,406

EMBRYO IMPLANTATION

Ostara Biomedical Ltd., ...

1. A composition of matter for use in improving pregnancy rates in females prior to implantation of an embryo or prior to insemination, the composition consisting essentially of recombinant IL-12, wherein the composition is configured to release the recombinant IL-12 in situ in a vagina within a physiological concentration range as corresponding IL-12 found in seminal fluid of a fertile male.

US Pat. No. 10,987,402

PHARMACEUTICAL COMPOSITIONS OF WATER SOLUBLE PEPTIDES WITH POOR SOLUBILITY IN ISOTONIC CONDITIONS AND METHODS FOR THEIR USE

Strongbridge Dublin Limit...

1. A pharmaceutical composition comprising:veldoreotide acetate;
an excipient, wherein the excipient comprises a monosaccharide, a disaccharide, polysaccharide, cyclic polysaccharide, cyclic oligosaccharide, cyclodextrin or ?-cyclodextrin;
and a polymeric microsphere, wherein veldoreotide acetate-is encapsulated in the polymeric microsphere, and wherein the surface area of the polymeric microsphere is from about 7 m2/g to about 12 m2/g.

US Pat. No. 10,987,393

METHOD FOR PREVENTING AND CONTROLLING BACTERIAL INFECTIONS IN SALMONID FISH USING QUILLAJA SAPONARIA EXTRACTS

SAPONIN RESEARCH CENTER S...

1. A method for controlling a bacterial disease caused by Piscirickettsia salmonis in Salmo salar fish, wherein said method comprises administering to Salmo salar fish an effective amount of a medicinal composition comprising a Quillaja saponaria extract as active ingredient and an appropriate excipient; wherein said Quillaja saponaria extract contains saponins.

US Pat. No. 10,987,392

METHOD FOR PREVENTING AND CONTROLLING VIRAL INFECTIONS IN SALMONID FISH USING QUILLAJA SAPONARIA EXTRACTS

SAPONIN RESEARCH CENTER S...

1. A method for controlling a viral disease caused by the Infectious Pancreatic Necrosis virus (IPNv) in Salmo salar fish, wherein said method comprises administering to Salmo salar fish an effective amount of a medicinal composition comprising a Quillaja saponaria extract as active ingredient and an appropriate excipient; wherein said Quillaja saponaria extract contains saponins.

US Pat. No. 10,987,379

HYPOCHLOROUS ACID FORMULATIONS AND METHODS FOR TREATING SKIN CONDITIONS

URGO US, INC., Fort Wort...

1. A method for treating pruritus in an Epidermolysis Bullosa (EB) subject, comprising:applying to affected areas of the skin of the subject a hypochlorous acid formulation having an amount of hypochlorous acid effective to reduce or inhibit pruritus associated with EB, wherein the hypochlorous acid formulation comprises at least 300 ppm of available free chlorine (AFC), and wherein AFC is at least 80% hypochlorous acid relative to the total of hypochlorous acid, hypochlorite, and Cl2 in the hypochlorous acid formulation.

US Pat. No. 10,987,377

USE OF INHALED GASEOUS NITRIC OXIDE AS A MUCOLYTIC AGENT OR EXPECTORANT

Advanced Inhalation Thera...

1. A method of treating inflammatory airway disease characterized by excessive mucus accumulation comprising administering through inhalation a therapeutically effective amount of nitric oxide containing gas to a human exhibiting inflammatory airway disease, wherein the nitric oxide containing gas is administered substantially coincident with the inspiration of the human, resulting in the reduction of inflammation; wherein the therapeutic concentration of nitric oxide gas in the human's airway is about 160 ppm to about 400 ppm; and wherein treating the inflammatory airway disease results in the flow of non-viscous liquids and mucus reduction.

US Pat. No. 10,987,376

METHODS OF TREATING AND/OR PREVENTING NAIL DISORDERS AND/OR IMPROVING THE APPEARANCE OF A NAIL

Chesson Laboratory Associ...

1. A method of treating onychodystrophy, where the onychodystrophy is not caused by onychomycosis, in a subject comprising:topically applying a composition comprising a poly(urea-urethane) to a nail of said subject wherein the composition forms a film permeable to water vapor.

US Pat. No. 10,987,374

COMPOSITION FOR PROMOTING PRODUCTION OF IMMUNOSTIMULATORY FACTOR

KYOTO UNIVERSITY, Kyoto ...

1. A method for promoting immunostimulatory factor production in an animal or human, comprising administering a composition comprising a genomic double-stranded RNA of a plant-derived endornavirus to the animal or human.

US Pat. No. 10,987,360

HEPATITIS B CORE PROTEIN MODULATORS

Assembly Biosciences, Inc...

1. A compound represented by
wherein
Y is selected from the group consisting of S(O)y, C?O, C(R11)2, NRY and O wherein y is 0, 1, or 2;
RY is selected from the group consisting of H, methyl, ethyl, propyl, proprene, butyl, phenyl and benzyl;
RZ is selected from the group consisting of H, methyl, ethyl, propyl, phenyl and benzyl;
Rm? and Rm are each independently selected from the group consisting of H, C1-6alkyl optionally substituted by one, two or three substituents each independently selected from halogen and hydroxyl, and C2-6alkenyl optionally substituted by one, two or three substituents each independently selected from halogen and hydroxyl;
Rc is selected from the group consisting of H, C1-6alkyl and C2-6alkenyl;
R78 is selected from the group consisting of H, cyano, CHO, C1-6alkyl, carboxy, —C(O)—O—C1-6alkyl; —NR?R?; phenyl optionally substituted with one, two, three or four substituents each independently selected from the group consisting of R73; benzyl optionally substituted with one or more substituents each independently selected from the group consisting of R73, a saturated or partially unsaturated 4-7 membered ring structure containing one to three heteroatoms selected from the group consisting of nitrogen, oxygen, and sulfur, wherein the saturated or partially unsaturated 4-7 membered ring structure is optionally substituted with one or more substituents each independently selected from the group consisting of R73; 5-6 membered monocyclic heteroaryl containing one to three heteroatoms selected from the group consisting of nitrogen, oxygen, and sulfur, wherein the 5-6 membered monocyclic heteroaryl is optionally substituted with one or more substituents each independently selected from the group consisting of R73; 9-10 membered bicyclic heteroaryl containing one to three heteroatoms selected from the group consisting of nitrogen, oxygen, and sulfur, wherein the 9-10 membered bicyclic heteroaryl is optionally substituted with one or more substituents each independently selected from the group consisting of R73 and X2—C0-6alkylene-R79;
X2 is selected from the group consisting of S(O)w (wherein w is 0,1, or 2), O, —C(O)— and NR?;
R79 is selected from the group consisting of H, halogen, hydroxyl, nitro, cyano, CHO, C1-6alkyl, —C(O)—O—C1-6alkyl, —C(O)—NR?R?, —C(?NH)—NR?R?, C2-6alkenyl, C2-6alkynyl, C1-6alkoxy, carboxy, NR?R?, —C(O)—C1-6alkyl, C3-6cycloalkyl, —NR?—C(O)—C1-6alkyl, NR?—C(O)—O—C1-6alkyl, —S(O)w—C1-6alkyl (where w is 0, 1 or 2), —S(O)w—NR?R? (where w is 0, 1 or 2), and —NR?—S(O)w—C1-6alkyl (where w is 0, 1 or 2);
R73 is selected from the group consisting of H, halogen, hydroxyl, nitro, cyano, CHO, oxo, C1-6alkyl, —C(O)—O—C1-6alkyl, —C(O)—NR?—C1-6alkyl, —C(?NH)—NR?R?, C2-6alkenyl, C2-6alkynyl, C1-6alkoxy, carboxy, NR?R?, —C(O)—C1-6alkyl, —C3-6cycloalkyl, NR?—C(O)—C1-6alkyl, NR?—C(O)—O—C1-6alkyl, —S(O)w—C1-6alkyl (where w is 0, 1 or 2), —S(O)w—NR?R? (where w is 0, 1 or 2), —NR?—S(O)w—C1-6alkyl (where w is 0, 1 or 2), C(O)—NR?—C1-6alkyl, C(O)—C1-3alkylene-NR?— C(O)—O—C1-6alkyl, and X2—C0-6alkylene-R79;
R? is selected, independently for each occurrence, from H, methyl, ethyl, cyclopropyl, cyclobutyl, and propyl;
R? is selected, independently for each occurrence, from H, methyl, ethyl, propyl optionally substituted by hydroxyl, butyl optionally substituted by hydroxyl, —C(O)-methyl and —C(O)-ethyl, or R? and R? taken together with the nitrogen to which they are attached may form a saturated or partially unsaturated 4-6 membered ring structure containing one to three heteroatoms selected from the group consisting of nitrogen, oxygen, and sulfur, wherein the saturated or partially unsaturated 4-6 membered ring structure is optionally substituted by one or more substituents selected from the group consisting of halogen, NH2, —C(O)—O—C1-6alkyl, —C(O)—C1-6alkyl, carboxy and C1-6alkyl;
R11, for each occurrence, is selected from the group consisting of H, halogen, and C1-6alkyl optionally substituted with one, two, or three halogens;
each of moieties R4, R5, R7, R8, R9, and R10 is independently selected for each occurrence from the group consisting of hydrogen, C1-6alkyl, C2-6alkynyl, C2-6alkenyl, halogen, hydroxyl, nitro, cyano, and NR?R?; and
wherein for each occurrence, C1-6alkyl, C2-6alkenyl or C2-6alkynyl may be optionally substituted with one, two, three or more substituents selected from the group consisting of halogen, hydroxyl, nitro, cyano, C3-6cycloalkyl, C2-4alkenyl, C2-4alkynyl, C1-3alkoxy, NR?R?, —NR?—S(O)w—C1-2alkyl (where w is 0, 1 or 2), NR?—C(O)—C1-3alkyl, NR?—C(O)—O—C1-3alkyl, and S(O)w—NR?R? (where w is 0, 1 or 2); C1-6alkoxy may be optionally substituted with one, two, three or more substituents selected from the group consisting of halogen, hydroxyl, nitro, cyano, carboxy, C1-3alkyl, NR?R?, —NR?—S(O)w—C1-2alkyl (where w is 0, 1 or 2), and S(O)w—NR?R?; C1-6alkylene may be optionally substituted by a substituent selected from the group consisting of C3-6cycloalkyl, hydroxyl, cyano, and halogen;
or a pharmaceutically acceptable salt thereof.

US Pat. No. 10,987,359

OXADIAZEPINONE DERIVATIVES AND METHODS OF TREATING HEPATITIS B INFECTIONS

Novira Therapeutics, Inc....

1. A compound of Formula IA:
or a pharmaceutically acceptable salt thereof, wherein
A is N or C(H);
R1 is H, C1-C6-alkyl, C1-C6-alkenyl, or C1-C6-alkyl-OH;
R2 is, at each occurrence, independently selected from —OH, halo, C1-C6-alkyl, C1-C6-alkenyl, C0-C6-alkyl-C3-C6-cycloalkyl, C0-C6-alkyl-4-5 membered heterocyclyl, C0-C6-alkyl-OR6, C0-C6-alkyl-N(R7)2, C0-C6-alkyl-SR8, C0-C6-alkyl-S(O)R8, C0-C6-alkyl-S(O)2R8, C0-C6-alkyl-C(O)OR9, C0-C6-alkyl-OC(O)R9, C0-C6-alkyl-OC(O)OR9, C0-C6-alkyl-OC(O)N(R7)2, and C0-C6-alkyl-C(O)N(R7)2, and wherein alkyl, cycloalkyl, and heterocyclyl are optionally substituted with 1, 2, or 3 groups, each independently selected from —OH and halo;
R3 is, at each occurrence, independently selected from —OH, halo, C1-C6-alkyl, C1-C6-haloalkyl, —O—C1-C6-alkyl, and C1-C6-alkyl-OH;
R4 is selected from (CRaRb)p-6-membered heteroaryl, (CRaRb)p—C6-C12-aryl, (CRaRb)p—C3-C7-cycloalkyl, and C0-C6-alkyl-4-5 membered heterocyclyl, wherein the heteroaryl contains one to four heteroatoms, and wherein heteroaryl, aryl, cycloalkyl, and heterocyclyl are optionally substituted with 1, 2, 3, or 4 groups, each independently selected from —OH, halo, —CN, —SF5, C1-C6-alkyl, C1-C6-haloalkyl, —O—C1-C6-alkyl, and C1-C6-alkyl-OH;
R5 is selected from H, C1-C6-alkyl, and C1-C6-alkyl-OH;
R6 is selected from H, C1-C6-alkyl, C1-C6-haloalkyl, C1-C6-alkenyl, and C0-C6-alkyl-C3-C6-cycloalkyl;
R7 is selected from H, C1-C6-alkyl, C1-C6-haloalkyl, C1-C6-alkyl-OR10, —C(O)C1-C6-alkyl, —C(O)C1-C6-haloalkyl, —C(O)C1-C6-alkyl-OR10, —C(O)C1-C6-alkyl-CN, —C(O)C3-C7-cycloalkyl, —C(O)O—C1-C6-alkyl, —C(O)O—C1-C6-haloalkyl, —C(O)O—C3-C7-cycloalkyl, —C(O)N(R10)2, —S(O)2C1-C6-alkyl, —S(O)2C1-C6-haloalkyl, and —S(O)2C3-C7-cycloalkyl; or
wherein two R7 groups, together with the N to which they are attached, form a 4-5 membered heterocycle, wherein the heterocycle is further independently and optionally substituted with 1 or 2 oxo or halogen substituents;
R8 is selected from H and C1-C6-alkyl;
R9 is selected from H and C1-C6-alkyl;
R10 is selected from H and C1-C6-alkyl;
Ra is, at each occurrence, independently selected from H, —OH, halo, C1-C6-alkyl, C1-C6-haloalkyl, —O—C1-C6-alkyl, and C1-C6-alkyl-OH;
Rb is, at each occurrence, independently selected from H and C1-C6-alkyl;
m is 0, 1, 2, 3, or 4;
n is 0, 1, 2, 3, or 4; and
p is 0, 1, 2, 3, or 4.

US Pat. No. 10,987,353

METHODS OF TREATING CANCERS OVEREXPRESSING CARM1 WITH EZH2 INHIBITORS AND PLATINUM-BASED ANTINEOPLASTIC DRUGS

The Wistar Institute of A...

1. A method of treating a cancer in a human subject suffering from the cancer in which cancer cells overexpress arginine methyltransferase CARM1 relative to an expression level in normal epithelial cells, the method comprising the step of administering a therapeutically effective dose of an enhancer of zeste homolog 2 (EZH2) inhibitor to the human subject, wherein the EZH2 inhibitor is(R)—N-((4-Methoxy-6-methyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-2-methyl-1-(1-(1-(2,2,2-trifluoroethyl)piperidin-4-yl)ethyl)-1H-indole-3-carboxamide (CPI-1205):

or a pharmaceutically acceptable salt thereof.

US Pat. No. 10,987,351

RORGAMMA MODULATORS AND USES THEREOF

Genfit, Loos (FR)

1. A compound of formula (Ia)
in which,
R1a is a hydrogen atom, a halogen atom, a nitrile group, a nitro group (NO2), a (C1-C6)alkyl group, a (C1-C6)alkyloxy group, a (C1-C6)alkylthio group, a —NH2 group, a (C1-C6)alkylamino group, a (C1-C6)dialkylamino group, or a heterocyclic group;
R1b is a hydrogen atom, a (C1-C6)alkyloxy group, a (C1-C6)alkyl group or a heterocyclic group;
R1c is a hydrogen atom, a halogen atom, a (C1-C6)alkyl group, a (C1-C6)alkyloxy group, a (C1-C6)alkylthio group, a heterocyclic group, a cyano group, an amido group or a hydroxyl group;
R1d and R1e are, independently, a hydrogen atom, a halogen atom, a (C1-C6)alkyloxy group or a (C1-C6)alkyl group;
wherein at least one R1a, R1b, R1c, R1d, and R1e is not a hydrogen atom;
R2 is a (C1-C6)alkyl group, a (C2-C6)alkenyl group, a (C2-C6)alkynyl group, a (C3-C14)cycloalkyl group, a (C6-C14)aryl group optionally substituted by a (C1-C6)alkyl or a heterocyclic group optionally substituted by a (C1-C6)alkyl group,
R?2 is a hydrogen atom; a (C1-C6)alkyl group; a (C2-C6)alkenyl group; a (C2-C6)alkynyl group; a (C3-C14)cycloalkyl group; a (C6-C14)aryl group optionally substituted by a (C1-C6)alkyl group or by a halogen atom; or a heterocyclic group optionally substituted by a (C1-C6)alkyl group or by a halogen atom,
or R2 and R?2 can form, together with the carbon atom to which they are attached, a (C3-C14)cycloalkyl group or a heterocycloalkyl group;
L is a NR7-CO—CH2, NR7-CO-C(CH3)2, CO—NH—CH2, or CO—NH-C(CH3)2 group, a NR7-CO—(C1-C6)alkyl group, a NR7-CO—(C3-C14)cycloalkylgroup, or a NR7-CO—CR5R?5 group;
R5 and R?5 are independently, a hydrogen atom, or a (C1-C6)alkylgroup;
or R5 and R?5 can form, together with the carbon atom to which they are attached, a cycloalkyl group;
each of X1 and X2 is a nitrogen atom;
R3 is a hydrogen atom, a (C1-C6)alkyl group, a carbonyl(C1-C6)alkyl group, a SO2R? group, a COOR? group, an amido group, a (C1-C6)alkylamido group, or a (C1-C6)dialkylamido group;
R? is a (C1-C6)alkyl group;
R4 is a hydrogen atom, a (C1-C6)alkyl group, or a halogen atom;
R7 is an hydrogen atom or a (C1-C6)alkyl group.

US Pat. No. 10,987,349

ANTITUMOR AGENT AND BROMODOMAIN INHIBITOR

FUJIFILM Corporation, To...

1. A method for treating tumor, comprising administering a therapeutically effective amount of a compound represented by the following formula [1] or a salt thereof, wherein the tumor is blood cancer, thymoma, myeloma, liver cancer, pancreatic cancer, ovarian cancer, prostate cancer, lung cancer, osteosarcoma, colon cancer, breast cancer, skin cancer, epithelial cell cancer, bladder cancer, lymphoma or stomach cancer:
wherein R1 represents an optionally substituted C1-6 alkyl group;
R2 represents a hydrogen atom;
R3 represents an optionally substituted C1-6 alkyl group, an optionally substituted C3-8 cycloalkyl group, or an optionally substituted heterocyclic group;
Z1, Z2 and Z3 each represents CH;
X1 represents
(1) a group represented by the formula C(?O)N(R6) (wherein the carbon atom binds to Ring A, and R6 represents a hydrogen atom, an amino-protecting group, or an optionally substituted C1-6 alkyl group),
(2) a group represented by the formula N(R7)C(?O) (wherein the nitrogen atom binds to Ring A, and R7 represents a hydrogen atom, an amino-protecting group, or an optionally substituted C1-6 alkyl group; or R7 represents, together with one substituent R4 of Ring A, an optionally substituted C2-4 alkylene group,
(3) an optionally substituted divalent cyclic hydrocarbon group that is formed by removing each one hydrogen atom on the two adjacent atoms, or
(4) an optionally substituted divalent heterocyclic group that is formed by removing each one hydrogen atom on the two adjacent atoms;
Ring A represents an aryl group;
an m number of R4, which are the same or different, each represents a halogen atom, an optionally substituted C1-6 alkyl group,
an optionally substituted C2-5 alkylene group formed together by the two adjacent R4,
an optionally substituted C2-4 alkylene group formed by one R4 together with R7, and
m represents an integer from 0 to 2.

US Pat. No. 10,987,348

MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS

Vertex Pharmaceuticals In...

1. A process of preparing a compound of the formula:comprising the steps of:a) reacting a compound of the formula:
with cesium carbonate and a compound of the formula:to form a mixture of compounds of the formulae:
b) reducing the mixture of compounds of the formulae:
with lithium aluminum hydride to form a compound of the formula:andc) reducing the compound of the formula:
with palladium on carbon and H2 to form a compound of the formula:

US Pat. No. 10,987,341

EDARAVONE SUSPENSION FOR ORAL ADMINISTRATION

MITSUBISHI TANABE PHARMA ...

1. An edaravone suspension for human oral administration, comprising:water;
edaravone particles comprising edaravone dispersed in the water; and
a dispersant dispersing the edaravone particles in water such that the dispersant maintains the edaravone particles in a solid particle state in the water,
wherein a blending amount of the edaravone particles is in a range of 0.5% (w/v) to 36% (w/v), and the dispersant is at least one dispersant selected from the group consisting of polyvinyl alcohol, methylcellulose, hypromellose, sucrose fatty acid ester and polysorbate.

US Pat. No. 10,987,338

COMPOSITION CONTAINING ARTESUNATE

1. A composition comprising artesunate dissolved in an organic base buffer solution, wherein the organic base has formula (I)
wherein R1 and R2 are H, and R3 is tris(hydroxylC1-2alkyl)C1-2alkyl and
wherein the concentration of said organic base is in the range of about 0.1 to about 0.5 mol/L and the composition has a pH in the range of about 7.2 to about 8.2.

US Pat. No. 10,987,334

METHOD OF TREATING ER MUTANT EXPRESSING BREAST CANCERS WITH SELECTIVE ANDROGEN RECEPTOR MODULATORS (SARMS)

UNIVERSITY OF TENNESSEE R...

1. A method of treating a subject suffering from ER mutant expressing breast cancer, comprising a step of administering to said subject a selective androgen receptor modulator (SARM) compound represented by a structure of formula II:whereinX is O;
G is O;
T is OH;
R is alkyl, haloalkyl, dihaloalkyl, trihaloalkyl, CH2F, CHF2, CF3, CF2CF3, aryl, phenyl, halogen, alkenyl or OH;
R1 is CH3;
Z is NO2 or CN;
Y is CF3, F, Br, Cl, I, or CN;
Q is CN, alkyl, halogen, NHCOR, NHCOOR, CONHR, NHCSCH3, NHCSCF3, or NHCSR;
wherein said ER mutant expressing breast cancer is Y537S mutation expressing breast cancer, and wherein said treating does not include preventing.

US Pat. No. 10,987,330

TREATMENT OF NERVOUS SYSTEM DISORDERS USING COMBINATIONS OF RXR AGONISTS AND THYROID HORMONES

Io Therapeutics, Inc., H...

1. A method of treating traumatic central nervous system (CNS) injury-associated demyelination or neuroinflammation, the method comprising administering to a human individual in need thereof a therapeutically effective amount of a RXR agonist and a thyroid hormone, wherein administration of the combination of the RXR agonist and the thyroid hormone treats the traumatic CNS injury in the individual, wherein the RXR agonist is 3,7-dimethyl-6(S),7(S)-methano,7-[1,1,4,4-tetramethyl-1,2,3,4-tetrahydronaphth-7-yl]2(E),4(E) heptadienoic acid, and has the structure of formula III:
wherein the combination of RXR agonist and thyroid hormone causes a greater improvement in the traumatic CNS injury than the RXR agonist or thyroid hormone alone;
and wherein the traumatic CNS injury is traumatic spinal cord injury.

US Pat. No. 10,987,328

CONTROLLED RELEASE DOSAGE FORM

OSMOTICA KERESKEDELMI ES ...

1. A method of treating a human patient in need of treatment for spasticity associated with multiple sclerosis, comprising administering twice-daily a composition comprising drug and excipients, said drug consisting of about 2.5 mg to about 50 mg of arbaclofen (ARBAC), and/or a corresponding amount of one or more pharmaceutically acceptable salt(s) of ARBAC, said composition providing the following in vitro release under conditions defined in USP <711> using a Type H apparatus with 900 ml 0.1 N HCl stirred at 50 rpm and maintained at a temperature of 370.5° C.: about 40% by wt to about 80% by wt of the drug is released after six hours, about 55% by wt to about 100% by wt of the drug is released after 8 hours, and not less than 70% of the drug is released after 12 hours, or wherein about 45% by wt to about 85% by wt of the drug is released after six hours, about 65% by wt to about 100% of the drug is released after 8 hours, and no less than 75% by wt of the drug is released after 12 hours.

US Pat. No. 10,987,325

COMPOSITIONS AND USES THEREOF FOR TREATING INFLAMMATORY DISEASES AND PROBIOTIC COMPOSITIONS

CHAIN Biotechnology Limit...

1. A composition comprising genetically engineered anaerobic bacteria that produce 3-hydroxybutyrate (3-HB), and an orally ingestible solid carrier, for delivering 3-HB to the lumen of the GI tract.

US Pat. No. 10,987,324

METHODS AND COMPOSITIONS FOR THE TREATMENT OF SEIZURE-RELATED DISORDERS

Adamas Pharmaceuticals, I...

1. A method of treating partial onset seizures in a human patient in need thereof, comprising administering to said human patient orally, once daily, a therapeutically effective dose of a pharmaceutical composition, wherein said pharmaceutical composition comprises a plurality of pellets, each pellet comprising:(i) a pellet core comprising a drug, wherein the drug is lacosamide or a pharmaceutically acceptable salt thereof;
(ii) an extended release coating comprising (a) ethylcellulose, (b) povidone or hypromellose, and (c) diethyl phthalate or medium chain triglycerides; and
(iii) a pH dependent coating comprising at least one polymer comprising methacrylic acid or a methacrylic ester;
wherein said pharmaceutical composition has a dissolution profile characterized by less than 2.3% release at two hours, and one or more of the following:
(a) less than 25% release at 4 hours,
(b) at least 35% release at 9 hours,
(c) at least 65% release at 12 hours,
wherein said dissolution is carried out in 900 mL simulated gastric fluid (pH 1.2) at 37±0.5° C. for the first two hours, followed by 900 mL simulated intestinal fluid (pH 6.8) at 37±0.5° C. for the subsequent four hours, followed by 900 mL phosphate buffer (pH 7.5) at 37±0.5° C. for the subsequent 18 hours, wherein all dissolution is performed in a USP Apparatus 1 (Basket), with a rotational speed of 100 rpm; and
wherein said pharmaceutical composition has a plasma concentration profile for said drug characterized by a Tmax of 8 to 20 hours as determined by oral administration of a single dose of said pharmaceutical composition to a fasted human subject.

US Pat. No. 10,987,322

IMMUNOREGULATORY AGENTS

Flexus Biosciences, Inc.,...

1. A compound having the formula:
or a pharmaceutically acceptable salt, hydrate or solvate thereof, wherein,
X1 is selected from the group consisting of halogen, CN, SO2NH2, NHSO2CH3, NHSO2CF3, OCF3, SO2CH3, SO2CF3, optionally substituted C1-C4 alkyl, optionally substituted C1-C4 alkoxy, C1-C4 haloalkyl, cyclopropyl, and CONH2;
X2 is selected from the group consisting of hydrogen, halogen, CN, SO2NH2, NHSO2CH3, NHSO2CF3, OCF3, SO2CH3, SO2CF3, optionally substituted C1-C4 alkyl, optionally substituted C1-C4 alkoxy, C1-C4 haloalkyl, cyclopropyl, and CONH2; and when X1 and X2 are on adjacent vertices of the phenyl ring they are optionally joined together to form an optionally substituted 5- or 6-member aromatic or aliphatic ring containing 0, 1, or 2 heteroatoms;
R1 is selected from the group consisting of optionally substituted C3-C8 cycloalkyl, optionally substituted C3-C8 cycloalkyl-C1-C4 alkyl, and optionally substituted 3- to 7-membered cycloheteroalkyl; and
R2 is hydrogen;
or R1 and R2 are joined together to form an optionally substituted C3-C8 cycloalkyl;
with the proviso that R1 and R2 do not join together to form an unsubstituted cyclohexane ring.

US Pat. No. 10,987,320

METHODS AND COMPOSITIONS FOR PREVENTING OR TREATING CALCIPHYLAXIS

Epizon Pharma, Inc., New...

1. A method of treating calciphylaxis in a human subject in need thereof, the method comprising administering to the human subject (a) menaquinone-7 (MK-7) and/or menaquinol-7 (MKH2-7); and (b) a statin; whereupon the administration of the MK-7 and/or MKH2-7:(i) increases a plasma level of Fetuin A relative to the plasma level of Fetuin A prior to administration; or
(ii) decreases a plasma level of Highly Sensitive C Reactive Protein (hs-CRP) relative to the plasma level of hs-CRP prior to administration.

US Pat. No. 10,987,319

TFEB ACTIVATOR C1 AMELIORATES APP AND TAU PATHOLOGY AND RESCUES COGNITIVE DEFICITS IN NEURODEGENERATIVE DISEASES

Hong Kong Baptist Univers...

1. A method for reversing synaptic dysfunction and/or ameliorating memory deficits in a subject comprising administering a composition comprising an effective amount of a compound of formula C1:
to said subject,
wherein said effective amount of said compound of formula C1 is from 0.41 to 0.81 mg/kg per body weight of said subject daily;
wherein levels of beta-amyloid plaque load, carboxy terminal fragments of amyloid precursor protein and phosphorylated Tau in cortico-hippocampal section of the brain of said subject are reduced after said administering;
wherein said subject is a human adult.

US Pat. No. 10,987,313

MUCO-ADHESIVE, CONTROLLED RELEASE FORMULATIONS OF LEVODOPA AND/OR ESTERS OF LEVODOPA AND USES THEREOF

Impax Laboratories, LLC, ...

1. A multiparticulate controlled release levodopa solid oral dosage form comprising:(i) one or more immediate release levodopa components; and
(ii) one or more controlled release levodopa components wherein one or more of the controlled release levodopa components comprise one or more beads, pellets, tablets, minitablets, or granules comprising:
(a) core comprising levodopa and at least one pharmaceutically acceptable excipient;
(b) a coating surrounding the core comprising a muco-adhesive material; and
(c) a coating comprising an enteric material surrounding the coating comprising the muco-adhesive material and wherein the dosage form comprises 90 mg to 500 mg of levodopa.

US Pat. No. 10,987,312

CONTROLLED RELEASE DOSAGE FORM WITH ENHANCED PHARMACOKINETICS

OSMOTICA KERESKEDELMI ES ...

1. A method of treating spasticity, the method comprising orally administering to a subject in need thereof a daily dose of arbaclofen (ARBAC) in one or more extended release dosage forms, whereinsaid one or more extended release dosage forms contains a lower daily dose of ARBAC as compared to one or more immediate release reference dosage forms;
said one or more extended release dosage forms provides at least the same therapeutic efficacy and reduced adverse events as compared to said one or more immediate release reference dosage forms; and
a) said one or more extended release dosage forms provides a higher AUC0-inf and higher Cmax and a longer Tmax than that provided by said one or more immediate release reference dosage forms; or
b) said one or more extended release dosage forms provides an AUC0-inf and a Cmax that are about the same as the AUC0-inf and Cmax, respectively, provided by said one or more immediate release reference dosage forms and a longer Tmax than that provided by said one or more immediate release reference dosage forms.

US Pat. No. 10,987,311

EXTENDED RELEASE COMPOSITIONS COMPRISING PYRIDOSTIGMINE

KASHIV SPECIALTY PHARMACE...

1. A gastroretentive dosage form comprising an extended release portion and an immediate release portion,wherein the extended release portion comprises a core comprising from about 50 mg to about 400 mg of pyridostigmine or a pharmaceutically acceptable salt thereof, an acid, a gas-generating agent, and a swellable water-soluble hydrophilic polymer; and a permeable elastic membrane surrounding the core and comprising a plasticizer, and a copolymer based on ethyl acrylate, methyl methacrylate, and trimethylammonioethyl methacrylate chloride (1:2:0.2), and
the immediate release portion comprises an immediate release drug layer containing from about 10 mg to about 60 mg of pyridostigmine or a pharmaceutically acceptable salt thereof,
wherein the permeable elastic membrane contains at least one orifice wherein the swellable water-soluble hydrophilic polymer is present in an amount of from about 5 wt % to about 35 wt %, based on the total weight of the core,
wherein the acid is selected from the group consisting of succinic acid, citric acid, acetic acid, malic acid, fumaric acid, stearic acid, tartaric acid, boric acid, benzoic acid, and mixtures thereof,
wherein the gas generating agent is selected from the group consisting of carbonate salts of alkali metals, carbonate salts of alkaline earth metals, bicarbonate salts of alkali metals, bicarbonate salts of alkaline earth metals, and mixtures thereof,
wherein the swellable water-soluble hydrophilic polymer is selected from the group consisting of hydroxypropyl methylcellulose, hydroxypropyl cellulose, methyl cellulose, a polyethylene oxide polymer, a carbomer, sodium alginate, and mixtures thereof, and
wherein the dosage form provides an extended release, with reduced initial burst release, of pyridostigmine or a pharmaceutically acceptable salt thereof, for at least about 14 hours, and
wherein the reduced initial burst release comprises an in vitro release of less than 35% of the pyridostigmine or a pharmaceutically acceptable salt thereof, within 2 hours of dissolution in a dissolution medium comprising 50 mM acetate buffer with 100 mM NaCl.

US Pat. No. 10,987,305

PREPARATION OF RESPIRABLE ZAFIRLUKAST PARTICLES

Cipla Limited, Mumbai (I...

1. A method for the preparation of respirable zafirlukast monohydrate particles comprising the steps of:a. preparation of an aqueous suspension of amorphous zafirlukast;
b. size-reduction with conversion of the suspended zafirlukast into crystalline monohydrate nanoparticles;
c. isolation of the crystalline zafirlukast in the form of a dry powder;
wherein the size-reduction step comprises a high energy input technique.

US Pat. No. 10,987,301

METHODS AND COMPOSITIONS FOR TREATING DAMAGED HAIR

Salon Commodities, Inc., ...

1. A method for treating hair damage, the method comprising contacting the hair with an effective amount of at least one compound of formula (I):wherein:R1-R4 are methyl;
R5 and R6 are the same or different and each is C1-26 alkyl or a substituent of the formula:

A is selected from one or more of (CH2—CH2—O)x, (CH(CH3)—CH2—O)y, and (CH2—CH(CH3)—O)z, wherein x, y, and z are the same or different and each is from 0-20, provided that at least one of x, y, or z is 1;
a is from 0-20;
b is from 0-20; and
c is from 0-30,provided that c is at least 1 and, when a is 0, then at least one of R5 and R6 is a substituent of the formula:

US Pat. No. 10,987,290

AEROSOL FOAM SKIN CLEANSER

The Procter and Gamble Co...

1. A packaged aerosol foaming skin cleanser, comprising:a) a multiphase skin cleansing composition, comprising a structured cleansing phase and a benefit phase, wherein the structured cleansing phase comprises a branched anionic surfactant, and the benefit phase comprises a first hydrophobic benefit agent selected from the group consisting of petrolatum, glycerides, butylated hydroxytoluene, sucrose polyesters, lanolin, lanolin derivatives, lanolin esters, lanolin oil, natural waxes, synthetic waxes; wherein the multiphase cleansing composition is shear thinning; wherein the multiphase composition is a dispersion;
b) a foaming agent comprising a hydrofluoroolefin, a hydrochlorofluoroolefin, or a combination thereof; and
c) a package for dispensing the aerosol foaming skin cleanser.

US Pat. No. 10,987,286

HAIR COMPOSITIONS AND METHODS OF USE THEREOF

Living Proof, Inc., Bost...

1. A hair treatment composition comprisingat least one monohydric alcohol having 1 to 6 carbon atoms;
hollow, fluid-filled microspheres, wherein the microspheres are present at a level of 0.01% to 2.0% by weight of the composition, have a mean particle size of 10 to 40 micron, and have a density of 0.01 g/cm3 to about 0.6 g/cm3 in the expanded state;
at least one polymer fixative present at a level of 0.1% to 10% by weight of the composition; and
at least one propellant present at a level of 65% to 85% by weight of the composition, wherein the composition is essentially anhydrous.

US Pat. No. 10,987,279

SYSTEMS AND METHODS FOR MANUAL COUNTABLES

Express Scripts Strategie...

1. A system comprising:a distribution section including a robot and a scanner, the robot being configured to select and pick a container from the distribution section and move the container to the scanner to identify one of a plurality of various order units to be dispensed in the container;
a manual section positioned adjacent the distribution section, the manual section including a plurality of handling areas and a plurality of shelving areas for storing the plurality of various order units;
at least one feed conveyor configured to transport the container from the distribution section to the at least one of the plurality of handling areas; and,
at least one return conveyor configured to transport the container from the at least one of the plurality of handling areas to the distribution section;
wherein the robot is configured to move the container from the distribution section to the selected handling area including at least one of the plurality of shelving areas that is storing one of the plurality of various order units using the identification by the scanner;
wherein the robot is further configured to place the container on the at least one feed conveyor based on the identification, and
wherein the robot is further configured to retrieve the container from the at least one return conveyor, move the container to the scanner to identify the container, and place the container in a pallet.

US Pat. No. 10,987,277

PRESSURE-REGULATING VIAL ADAPTORS

ICU Medical, Inc., San C...

1. An adaptor configured to couple with a sealed vial, the adaptor comprising:a connector interface;
an access channel in fluid communication with the connector interface;
a regulator assembly comprising:
a first regulator inlet in fluid communication with an ambient environment surrounding the adaptor;
a first regulator lumen;
a second regulator inlet in fluid communication with the ambient environment;
a second regulator lumen;
a first filter capable of fluid communication with the first regulator lumen and configured to filter fluid passing into the first regulator lumen;
a second filter in fluid communication with the second regulator lumen and configured to filter fluid passing from the second regulator lumen and into the ambient environment; and
a regulator valve in fluid communication with the first regulator lumen, the regulator valve configured to permit passage of fluid from the ambient environment into the first regulator lumen, the regulator valve further configured to prevent passage of fluid from within the vial to the first filter, the regulator valve having a cracking pressure greater than or equal to 0.1 psi and less than or equal to 5 psi;
a piercing member comprising a proximal end and a distal end, the distal end comprising a piercing tip; and
a regulator channel positioned at least partially within the piercing member and comprising a first regulator channel opening in fluid communication with the first regulator lumen,
wherein the regulator assembly is configured to permit passage of fluid from the second regulator lumen to exit the adaptor and into the ambient environment.

US Pat. No. 10,987,276

DEVICE FOR STORING ELEMENTS

BIOLOG-ID, Boulogne-Bill...

1. A device configured to store a plurality of elements, each element including a wireless communication device, the device comprising:a plurality of drawer assemblies, each drawer assembly comprising
an upper end and a lower end,
a support comprising a housing and an assembly member with a respective complementary assembly member of the lower end or the upper end of the support of another of the drawer assemblies, so that the drawer assemblies are configured to be assembled on each other to form a vertical stack,
a drawer positioned in the housing of the support and slidable relative to the support, the drawer comprising a bottom defining a plurality of slots configured to receive an element,
for each slot, a single transmitter dedicated to the slot and configured to transmit radio frequency waves, the single transmitter being configured to communicate with all of the wireless communication devices,
wherein the bottom of the drawer is made of a material configured to be traversed by radiofrequency waves emitted by the or each single transmitter, and
wherein the or each single transmitter is disposed under the bottom of the drawer facing the corresponding slot of the bottom of the drawer in order to allow communication between the single transmitter and the wireless communication device of one of the elements received in the slot.

US Pat. No. 10,987,275

DETERMINING RETURN OF SPONTANEOUS CIRCULATION DURING CPR

KONINKLIKE PHILIPS N.V., ...

1. A device for supporting determination of return of spontaneous circulation (ROSC) during an associated cardiopulmonary resuscitation (CPR) procedure which is being performed on an associated patient, the device comprising:an input for receiving a signal from a photoelectric plethysmography (PPG) sensor and/or electrocardiogram (ECG) sensor for sensing a physiological signal of the associated patient;
a processor, which is adapted to:
perform frequency analysis of the physiological signal;
detect and discriminate pulseless electrical activity (PEA) components, compression-induced components and spontaneous pulse components within the physiological signal, wherein the spontaneous pulse component includes an arrhythmic spontaneous pulse component and a stable fundamental spontaneous pulse component and wherein the stable fundamental spontaneous pulse component has a detectable pulse rate; and
provide an output based on the detected PEA, compression-induced and spontaneous pulse components within the physiological signal to support determination that there has been ROSC;
and a display device,
wherein the processor is adapted to control the display device to output an image which shows the PEA components, compression-induced components and spontaneous pulse components within the physiological signal over time as a two-dimensional frequency-time plot with the arrhythmic spontaneous pulse component represented as discrete data points, and further wherein the stable fundamental spontaneous pulse component is displayed when spontaneous circulation returns to the associated patient, and further wherein a timer is displayed showing a duration that the stable fundamental spontaneous pulse component has been detected uninterruptedly.