US Pat. No. 10,967,153

SHAPE MEMORY MEDICAL DEVICE AND METHODS OF USE

C. R. Bard, Inc., Frankl...

1. A guidewire system, comprising:a shaped guidewire, comprising:
an elongate body with a proximal end and a distal end defining a longitudinal axis; and
a shaped portion made from a shape memory material, the shaped portion having a first configuration, deflected from the longitudinal axis, and designed to be malleable from the first configuration to a second deflected configuration, the shaped portion having a diameter the same as a diameter of the elongate body; and
an apparatus for positioning at an incision site on a corpus of a patient, the apparatus having a proximal end and a distal end, the apparatus interacting with the shaped portion of the shaped guidewire to prevent the shaped portion from advancing distally of the proximal end of the apparatus.

US Pat. No. 10,967,152

EXPANDABLE INTRODUCER SHEATH FOR MEDICAL DEVICE

Abiomed, Inc., Danvers, ...

1. An expandable sheath comprising:a sheath body having an inner surface and an outer surface, the inner surface defining a lumen that extends along a longitudinal axis between a proximal end and a distal end of the sheath body, the sheath body being comprised of:
at least one first member extending between the proximal end and the distal end of the sheath body, each first member comprising a first material having a first elastic modulus;
a plurality of second members, each second member extending between the proximal end and the distal end of the sheath body, and each second member comprising a second material having a second elastic modulus that is higher than the first elastic modulus; and
a plurality of third members, each third member extending between the proximal end and the distal end of the sheath body without overlapping any other third member of the plurality of third members, and each third member being at least partially encapsulated within one of the plurality of second members and comprising a third material having a third elastic modulus that is higher than the second elastic modulus,
wherein the sheath body is configured to be radially expandable from an unexpanded state to an expanded state to allow the passage of a portion of a medical device through the lumen, the portion of the medical device having a transverse cross-sectional area larger than a transverse cross-sectional area of the lumen when the sheath is in the unexpanded state.

US Pat. No. 10,967,151

STEERABLE CATHETER FOR THE IMPLANTATION OF A LEADLESS CARDIAC CAPSULE

CAIRDAC, Antony (FR)

1. A tool for the intracorporeal implantation of a medical device, the tool having a steerable catheter including a flexible tubular unit comprising a mobile tube received inside an intermediate tube,wherein the mobile tube and the intermediate tube are coaxial to each other, extend from a proximal end to a distal end of the steerable catheter and are telescopically mounted into each other and configured for mutual rotation and mutual axial translation,
wherein the mobile tube comprises at least one central lumen located radially in a central region near an axis of the steerable catheter and extending axially from the proximal end to the distal end,
wherein the intermediate tube comprises along its whole length a longitudinal notch radially offset in a direction of offset with respect to the axis of the steerable catheter and extending axially from the proximal end to the distal end,
wherein the longitudinal notch contains a cable adapted to undergo a traction exerted from the proximal end, the traction generating a bending of the steerable catheter directed towards the offset direction, and
wherein the steerable catheter further comprises around the intermediate tube a sealed external sheath surrounding the intermediate tube over a periphery of the intermediate tube and covering the longitudinal notch over the length of the longitudinal notch,
wherein a distal end of the mobile tube is integral with a member for coupling the mobile tube to a medical device to be implanted, and a distal end of the intermediate tube is integral with a tubular protective sleeve defining an inner volume adapted to receive the medical device to be implanted, with a degree of freedom in axial sliding and a degree of freedom in mutual rotation of the medical device to be implanted with respect to the tubular protective sleeve, and
wherein a distal end of the cable is axially integral with the tubular protective sleeve.

US Pat. No. 10,967,150

DEFLECTABLE CATHETER SHAFT SECTION

St. Jude Medical, Cardiol...

1. A deflectable catheter shaft section comprising the following:an elongated body extending along a longitudinal axis and comprising a distal end and a proximal end;
first and second pull wires, wherein each of the first and second pull wires has a proximal end and a distal end, and wherein each of the first and second pull wires extends along the elongated body;
first and second pull wire liners each disposed over a portion of one of the first and second pull wires, respectively, wherein each of the first and second pull wire liners has a proximal end and a distal end; and
a first gap between the proximal end of the first pull wire liner and the proximal end of the elongated body and a second gap between the proximal end of the second pull wire liner and the proximal end of the elongated body, wherein a longitudinal length of the first gap is greater than a longitudinal length of the second gap.

US Pat. No. 10,967,149

APPARATUS AND METHOD FOR EVERTING CATHETER FOR UTERINE ACCESS FOR BIOPSY AND CYTOLOGY

CrossBay Medical, Inc., ...

1. A method for retrieving a tissue sample from a uterus comprising:inserting a distal end of an elongated element into the uterus, wherein the elongated element has a lateral opening and a cover closeable over the lateral opening;
positioning the tissue sample in the elongated element; and
everting the cover over the opening.

US Pat. No. 10,967,148

PATIENT SPECIFIC GUIDE WIRE METHOD

1. A method of utilizing a guide wire for a surgical process which comprises:(a) scanning a heart and an annulus of a patient to generate an image;
(b) measuring said image to determine an optimal position of a prosthetic heart valve relative to the said heart and said annulus;
(c) forming an internal end of a guide wire to have an optimized shape for aligning said prosthetic heart valve to said optimal position; and,
(d) utilizing said guide wire with a heart valve deployment device as part of a surgical procedure to deploy said prosthetic heart valve within said patient.

US Pat. No. 10,967,147

RELIABILITY DETERMINATION OF ELECTRODE LOCATION DATA

1. A system for determining an error associated with an electrode disposed on a medical device, the system comprising:a processor; and
a memory storing instructions on a non-transitory computer-readable medium, wherein the instructions are executable by the processor to:
receive an electrode signal from the electrode disposed on the medical device;
receive a plurality of other electrode signals from a plurality of other electrodes disposed on the medical device; and
determine that the electrode signal received from the electrode disposed on the medical device is an outlier in relation to at least some of the plurality of other electrode signals from the plurality of other electrodes disposed on the medical device, based on a comparison between the electrode signal and the plurality of other electrode signals.

US Pat. No. 10,967,146

CONTROL METHOD AND APPARATUS FOR MANAGING SLEEP ENVIRONMENT

SAMSUNG ELECTRONICS CO., ...

6. A control device for managing a user's sleep environment, the control device comprising:a controller configured to obtain the user's sleep related information based on user sensing data sensed by a sensor and to generate a control signal that adjusts a first wavelength band output of at least one electronic device comprising a light source based on the sleep related information;
a memory configured to store a database; and
a transceiver configured to transmit the control signal to the at least one electronic device,
wherein the light source of the at least one electronic device is a display that simultaneously emits light of a plurality of wavelengths, and the sleep related information comprises at least one of a user sleep related state and a user hypnagogic stage immersion level,
wherein the sleep related information comprises the user hypnagogic state immersion level, the controller is configured to determine the user hypnagogic stage immersion level to generate a control signal that increases a blocking ratio of the first wavelength band output within a maximum blocking ratio based on the user sleep related state is a hypnagogic stage, to generate a control signal that fixes or reduces the blocking ratio of the first wavelength band output based on a user abnormal movement is detected, to accumulate the user hypnagogic stage immersion level and the blocking ratio of the first wavelength band output corresponding thereto at the database, and to calculate the blocking ratio of the first wavelength band output according to the user hypnagogic stage immersion level at a next hypnagogic stage based on the database,
wherein the hypnagogic stage immersion level is determined by comparing at least one of a data change, a data stabilizing speed, or a data value range of obtained data with a reference value stored in the database, and
wherein the hypnagogic immersion level represents an immersion execution rate until the user enters a non-rapid-eye movement stage when the user sleeps.

US Pat. No. 10,967,145

FILTER ASSEMBLY AND AIRWAY PRESSURE SUPPORT SYSTEM EMPLOYING SAME

KONINKLIJKE PHILIPS N.V.,...

1. An airway pressure support system, comprising:a housing having a port structure with an air inlet opening, the air inlet opening being disposed on a horizontal surface of the port structure, the port structure further including a first slot member and a second slot member within a respective first vertical side and second vertical side of the port structure; and
a filter assembly coupled to the housing via the port structure, the filter assembly being in fluid communication with the air inlet opening, wherein the filter assembly includes a housing portion having a first vertically disposed side wall, a second vertically disposed side wall opposite the first side wall, a front vertically disposed wall provided between the first side wall and the second side wall, a top wall connected to the front wall, the first side wall and the second side wall, and a bottom horizontally disposed portion opposite the top wall and having a first opening formed therein, the filter assembly further including a first filter media portion attached to the bottom portion, wherein the first filter media portion covers the first opening, and wherein the first filter media portion, the first side wall, the second side wall, the front wall, the top wall and the bottom portion form an inner chamber having a second opening opposite the front wall and in fluid communication with the first opening, via the first filter media portion, the filter assembly still further including a first spring member provided on an exterior of the first side wall, and a second spring member provided on an exterior of the second side wall, wherein the first and second spring members each have a vertically disposed floating portion configured to engage a respective top wall of the first slot member and the second slot member and provide a downward sealing force to be exerted against the filter assembly to create a seal between the bottom portion of the filter assembly and air inlet opening of the port structure of the housing, in response to the filter assembly being inserted into the port structure.

US Pat. No. 10,967,144

PATIENT INTERFACE COMPONENT

ResMed Pty Ltd, Bella Vi...

1. A pad for forming a seal forming structure against a user's skin for use with a patient interface, the pad comprisinga base layer,
a fiber layer comprising a plurality of fibers for contacting a patient's skin,
and a connection layer for connecting the fibers to the base layer,
wherein the base layer and/or the fiber layer is/are adapted to act as a reservoir for at least one substance;
wherein the base layer includes a first base surface and a second base surface, the first base surface configured to be positioned proximate to a cushion of the patient interface, and the second base surface being positioned opposite the first base surface;
wherein the connection layer includes a first connection surface and a second connection surface, the first connection surface being directly coupled to the second base surface, and the second connection surface being positioned opposite the first connection surface; and
wherein each fiber of the plurality of fibers includes a first end and a second end, each first end being directly coupled to the second connection surface and being spaced apart from the base layer, and each second end extending from the connection layer in a direction opposite to the second connection surface, each second end configured and oriented to contact the patient's skin.

US Pat. No. 10,967,143

MUCUS-REMOVING DEVICE

1. A self-contained vacuum aspirator comprisinga pump, a hose, a tracheostomy tube connector, and a control system;
wherein the hose attaches the pump to the tracheostomy tube connector;
wherein the tracheostomy tube connector attaches the self-contained vacuum aspirator to a tracheostomy tube of a patient;
wherein the control system regulates the operation of the pump;
wherein the self-contained vacuum aspirator is adapted for use with a patient;
wherein the vacuum aspirator is configured to interface with a patient having a tracheostomy tube, a pulmonary system, and mucus;
wherein the self-contained vacuum aspirator is configured for use with a tracheostomy tube;
wherein the self-contained vacuum aspirator generates a vacuum at the tracheostomy tube such that mucus is withdrawn from the pulmonary system through the tracheostomy tube and into the self-contained vacuum aspirator;
wherein the self-contained vacuum aspirator generates the vacuum at the tracheostomy for a fixed period of time;
wherein the hose further comprises a first fitting and a second fitting;
wherein the first fitting attaches to an end of the hose;
wherein the second fitting attaches to an end of the hose that is distal from the first fitting;
wherein the pump further comprises a pump fitting;
wherein the pump fitting receives the first fitting of the hose to form a gas impermeable seal between the hose and the pump;
wherein the first fitting inserts into the pump fitting;
wherein the control system comprises a master switch, an initiating switch, a timing circuit, a relay, a pull-up resistor,
wherein the control system is configured for use with an external power source;
wherein the master switch, the initiating switch, the timing circuit, the relay, and the pull-up resistor are electrically interconnected;
wherein the master switch is a maintained switch;
wherein the master switch electrically connects in series between the external power source and the control system.

US Pat. No. 10,967,142

SYSTEMS AND METHODS FOR TRACKING SPONTANEOUS BREATHING IN A MECHANICALLY VENTILATED PATIENT

ART MEDICAL Ltd., Netany...

12. A computing device for converting electrical signals including an indication of diaphragm movement to instructions for operating a mechanical ventilator mechanically ventilating a target individual, the computing device comprising:a probe for insertion into a distal end of an esophagus of the mechanically ventilated target individual;
at least one sensor comprising at least one electrode for sensing impedance values disposed near a distal end of the probe at a location such that the at least one electrode is located at the distal end of the esophagus of the target individual when the probe is located within the esophagus and in use, wherein the at least one electrode is positioned for sensing impedance values when contacting tissue of the esophagus including at least one of a lower esophageal sphincter (LES) and tissue in proximity to the LES; and
at least one hardware processor executing a code for: extracting a frequency band of diaphragm movement and a phase of the diaphragm movement of the mechanically ventilated target individual from the electrical signals including the indication of diaphragm movement, the signals including much larger amplitude signals generated based on the mechanical ventilator, and computing instructions to adjust ventilation frequencies and ventilation phases of the mechanical ventilator for mechanically ventilating the target individual by synchronizing to a wave form of the diaphragm movement in frequency band and phase of diaphragm movement for matching a waveform of the ventilator to the waveform of the diaphragm movement.

US Pat. No. 10,967,141

METHODS AND APPARATUS FOR VARYING THE BACK-UP RATE FOR A VENTILATOR

ResMed Pty Ltd

1. An apparatus for adjusting timing of delivery of breathable gas to a patient for the patient's respiration comprising:a breathable gas source configured to deliver the breathable gas to a patient, the delivery of the breathable gas being directed to the patient through a respiratory conduit of the apparatus,
a sensor for detecting patient respiration, and
a controller, including at least one processor, the controller coupled with the sensor and the breathable gas source, the controller configured to:
detect patient respiration with the sensor;
in a synchrony mode, control the breathable gas source to deliver inspiratory pressure and expiratory pressure in synchrony with the patient's detected respiration; and
in a timed mode, control the breathable gas source to deliver timed breaths with a timing threshold that is automatically adjusted by the controller;
wherein the timing threshold is automatically adjusted for the timed mode such that a rate for delivering timed breaths is periodically reduced from a vigilant rate to a relaxed rate to promote resynchronization between the apparatus and the patient's respiration.

US Pat. No. 10,967,140

DEVICE FOR DISPENSING A FLUID PRODUCT SYNCHRONISED WITH INHALATION

APTAR FRANCE SAS, Le Neu...

1. An inhalation-synchronized fluid dispenser device comprising a body provided with a mouthpiece, a fluid reservoir containing a fluid and a propellant gas amounted to slide axially in said body, a metering valve including a valve member assembled on said reservoir for selectively dispensing the fluid, wherein, during actuation, said valve member is stationary relative to said body and said reservoir is moved axially relative to said body between a distal position, which is a rest position, and a proximal position, said device further comprising:an actuator element that is movable between a non-actuation position in which said metering valve cannot be actuated, and an actuation position in which said metering valve can be actuated; and
an inhalation-controlled trigger system including an inhalation-sensitive member that is movable under the effect of inhaling, said inhalation-sensitive member, when moved, moving said actuator element from the non-actuation position towards the actuation position;
wherein said actuator element is a locking element that, in the non-actuation position, enables said valve member of the metering valve to move axially in the body, together with said reservoir moving between the distal position and the proximal position, preventing said metering valve from being actuated when said reservoir is moved axially in the body without inhaling; and
wherein, in the actuation position, said locking element prevents said valve member from moving axially relative to said body, such that, after inhaling, axial movement of said reservoir causes actuation of the metering valve.

US Pat. No. 10,967,139

MULTIDOSE INHALER

Novartis AG, Basel (CH)

1. A multiple dose powder inhalation device comprising:a body comprising an interior cavity and a cap that may be moved from a closed position to an open position;
a cartridge that is removably insertable into the interior cavity of the body, the cartridge comprising a mouthpiece through which aerosolized powder medicament may be delivered to a user, wherein the cap covers the mouthpiece when the cap is in the closed position and exposes the mouthpiece when the cap is in the open position, and wherein the cartridge houses a strip of receptacles, each receptacle adapted to contain a dose of powder medicament;
an aerosol engine adapted to aerosolize a dose of powder medicament and deliver it to the mouthpiece;
an advancing mechanism adapted to communicate with the strip of receptacles in the cartridge to selectively advance the strip of receptacles; and
a receptacle opening mechanism adapted to communicate with a piercing mechanism in the cartridge to selectively cause the piercing mechanism to create one or more openings into a receptacle, wherein the receptacle opening mechanism uses energy stored by movement of the cap.

US Pat. No. 10,967,138

END-OF-DOSE DETECTION IN NEBULIZERS

STAMFORD DEVICES LIMITED,...

1. A nebulizer comprising a vibrating aperture plate, a mounting, an actuator, and an aperture plate drive circuit having a controller, wherein the controller is configured to:measure aperture plate drive current at each of a plurality of measuring points in a scan, each measuring point being a drive frequency;
determine a minimum value of the drive current during the scan;
determine a value for maximum rate of change of drive current during the scan;
use said minimum drive current value in combination with said maximum rate of change value to execute an algorithm to calculate an indicator value for end-of-dose; and
automatically stop operation of the actuator upon detection of end-of-dose based on the indicator value.

US Pat. No. 10,967,137

INFUSION PUMP ASSEMBLY

DEKA PRODUCTS LIMITED PAR...

7. An infusion pump device for delivering infusible fluid to a user, the infusion pump device comprising:a pump portion comprising a motor assembly;
a plunger assembly comprising a plunger and a plunger rod, the plunger assembly having a threaded portion extending over an entire length of the plunger rod, the plunger assembly displaceable by the motor assembly; and
processing logic for executing one or more processes in the pump portion,
wherein the processing logic is configured to monitor a displacement of the plunger assembly to determine if the plunger assembly was displaced an expected displacement in response to displacement by the motor assembly, and
wherein if the plunger assembly was not displaced the expected displacement, initiating an alarm sequence on the infusion pump device.

US Pat. No. 10,967,136

PAIN-AVERTING DEVICE (PAD)

Felisha V. Fox, Minneapo...

1. An injection apparatus comprising:a base having a ring shaped bottom surface for placement against a patient's skin, wherein the base includes one or more apertures;
an anesthetic holder connected to and extending from the base that retains an anesthetic, wherein the holder is in fluid communication with the one or more apertures to dispense the anesthetic to the patient's skin;
one or more vibration motors affixed to the holder; and
a hollow cylinder having a first end, a second end, and a longitudinal body extending between said first and second end, wherein an opening in the first end is configured to receive an injecting pen longitudinally within an interior of the hollow cylinder and the second end is located concentrically adjacent to the base and is configured to allow the injecting pen to contact the patient's skin to administer an injection to the patient.

US Pat. No. 10,967,135

METHOD AND DEVICE FOR REMOVING GAS AND/OR GAS BUBBLES FROM A LIQUID MEDICAMENT STORED IN A RESERVOIR

Roche Diabetes Care, Inc....

1. A method for removing gas and/or gas bubbles from a liquid medicament used in an infusion pump, the method comprising:providing a reservoir containing liquid medicament and providing a displacing member that is at least partly displaceable relative to the reservoir;
providing a mechanical actuator configured to generate a mechanical oscillation; and
using the mechanical actuator to cause a mechanical impact to thereby transmit a mechanical oscillation to the displacing member and thereby generating a mechanical wave in the liquid medicament, wherein the wave removes gas and/or gas bubbles from the liquid medicament.

US Pat. No. 10,967,134

INJECTION NEEDLE ASSEMBLY AND MEDICINE INJECTION DEVICE

TERUMO KABUSHIKI KAISHA, ...

1. A method of using a medicine injection device comprising a syringe filled with a medicine and having an output portion; a needle tube having a needle tip for puncturing the skin; a needle hub including a retention part for retaining the needle tube and an insertion part into which an output portion of the syringe is inserted; a flange-like skin contact portion that is disposed in a manner so as to cover an area surrounding the needle tube and makes contact with and/or faces the skin when the living body is punctured with the needle tube, the flange-like skin contact portion comprising an adjustment portion that is disposed in an area surrounding the needle tube and includes a needle protrusion surface from which the needle tip of the needle tube protrudes, and a cylindrically formed stabilizer that is disposed in a manner so as to cover an area surrounding the needle tube and makes contact with skin when a living body is punctured with the needle tube; and a fluid-draining portion that is disposed in the flange-like skin contact portion of the needle hub, said method comprising:removing air from the medicine injection device prior to injection of the medicine, whereby medicine spilled from the needle tip is caught in the fluid-draining portion;
draining the spilled medicine in the fluid-draining portion by tipping the medicine injection device;
positioning the flange-like skin contact portion adjacent the skin, the positioning of the flange-like skin contact portion adjacent the skin including placing an end face of the stabilizer adjacent the skin such that needle tip of the needle tube is facing the skin to be punctured;
puncturing the skin with the needle tip; and
injecting medicine from the needle tip into the skin.

US Pat. No. 10,967,133

MOUNTING FEATURE FOR ACCESSORY DEVICE

1. An assembly comprising an add-on device and a drug delivery device, the add-on device being configured to be releasably mountable on the drug delivery device, the drug delivery device comprising:a first housing comprising a first mounting surface with an associated first positioning structure,
a drug reservoir or structure for receiving a drug reservoir,
drug expelling structure comprising a dose setting member allowing a user to set a dose amount of drug to be expelled,
an actuation member actuatable between a first and a second state, the first state allowing a dose amount to be set, the second state allowing the drug expelling structure to expel a set dose,
an indicator member adapted to display the set dose amount during dose setting, and to display the remaining dose amount to be expelled during drug expelling, and
a window structure comprised in the first housing allowing a user to observe a portion of the indicator member during dose setting, the window structure, being in the form of an opening formed in the first housing, the opening being surrounded by an edge portion formed by the housing,the add-on device comprising:a second housing comprising a second mounting surface with an associated second positioning structure adapted to engage the first positioning structure form-fittingly when the add-on device is mounted on the drug delivery device,
a mounting switch actuatable between a non-mounted and a mounted state,
a camera opening formed in the mounting surface, the second positioning structure surrounding at least in part the camera opening,
a camera adapted to capture an image of at least a portion of the indicator member arranged in alignment with the camera window, and
a processor adapted to determine an expelled dose amount based on input from the camera,wherein:the window structure forms the first positioning structure, the edge portion forming at least in part the first positioning structure,
the mounting switch and the positioning structures are configured such that the switch is actuated when but not before the first and second positioning structures have at least partly form-fittingly engaged each other, and
the second positioning structure protrudes from the second mounting surface and is adapted to engage at least portions of the window structure to thereby position the logging device axially and rotationally relative to the opening,
the mounting switch is arranged in the vicinity of the second positioning structure,
the mounting switch comprises a switch member protruding from the second mounting surface and being adapted to engage the drug delivery device, and
the second positioning structure protrudes farther from the second mounting surface than the switch member.

US Pat. No. 10,967,132

MEDICAMENT DELIVERY DEVICE

SHL MEDICAL AG, Zug (CH)...

1. Two delivery assemblies for medicament delivery devices, comprising:a first delivery assembly and a second delivery assembly that is a separate structure and not part of the first delivery assembly, each of the first delivery assembly and the second delivery assembly comprising:
a distal assembly comprising:
a distal housing part having a proximal end and a distal end, where the proximal end has a single opening;
a plunger rod positioned with the distal housing part that moves axially in a proximal direction through the single opening during dose delivery; and
a third mechanically coded interface device arranged on the proximal end of the distal housing part,
a proximal assembly comprising;
a proximal housing part having a proximal end and a distal end and releasably connected to the distal housing part;
a medicament container containing a medicament, where the medicament container has a slidable stopper and is configured to be positioned within the proximal housing part; and
an interface member having a first mechanically coded interface device, where the interface member of the first delivery assembly is configured to match and interact with the third mechanically coded interface device of the first delivery assembly when the distal and proximal housing parts are connected to each other, wherein each of the interface members is a separate stand-alone structure that is not part of, or connected to, either the distal or proximal housing parts until the distal and proximal housing parts are connected to each other,
wherein the distal housing part of the first delivery assembly is a separate stand-alone structure that is not part of, or connected to, the distal housing part of the second delivery assembly,
wherein the first mechanically coded interface device on the interface member of the first delivery assembly is different from the first mechanically coded interface device on the interface member of the second delivery assembly such that the interface member of the first delivery assembly cannot connect to the third mechanically coded interface device of the second delivery assembly,
wherein the plunger rod of the first delivery assembly is arranged within and moves axially through the single opening in the distal housing part of the first delivery assembly and the plunger rod of the second delivery assembly is arranged within and moves axially through the single opening in the distal housing part of the second delivery assembly.

US Pat. No. 10,967,131

ASSEMBLY TO ADMINISTER INSULIN FROM A CARTRIDGE

EMPERRA GMBH E-HEALTH TEC...

1. A replaceable adapter assembly being adapted and configured to be used in a device for the administration of a selected dosage of insulin or other medicaments from a cartridge, the device comprising a housing with a removable front portion and the claimed replaceable adapter assembly comprises:(a) a cartridge with a moveable plug guided in said cartridge,
(b) a first threaded element formed by a threaded rod with an external, male thread and a thread lead, movable in a first direction to move the plug; and
(c) a casing having an open side for receiving the cartridge and which is provided with an aperture at its opposite end for guiding said threaded rod in a rotationally secured way, and
(d) a second threaded element formed by a nut and threaded with a thread lead matching the thread lead of the threaded rod for adjusting a dose, pivotably screwed to said threaded rod outside of said casing and limiting movement of said threaded rod in the first direction, and wherein
(d) the first and the second threaded element are integral parts of the replaceable adapter assembly and said thread lead of said first element and said thread lead of said second threaded element are adapted to the dimension and/or the content of said cartridge,
and wherein said first and second threaded elements of said replaceable adapter assembly correspond to an opening of said housing of the device so as to be frontally insertable into the housing, and wherein an outer surface of said case of the replaceable adapter assembly corresponds to an inner surface of said front portion of the housing so that the replaceable adapter assembly is securable in its position by connecting the front portion to the housing.

US Pat. No. 10,967,130

SYRINGE CARRIER

Sanofi-Aventis Deutschlan...

1. A method comprising:axially inserting a syringe into a syringe carrier via a proximal open end of the syringe carrier, the syringe comprising a barrel, a neck extending distally from the barrel, a needle extending distally from the neck, and a rigid needle shield covering the needle, and the syringe carrier comprising an elongate body having a slot extending proximally from a distal end of the elongate body to form a c-shaped distal end region and one or more projections extending radially inward from the c-shaped distal end region;
axially advancing the syringe within the syringe carrier such that the rigid needle shield slides along the one or more projections of the c-shaped distal end region of the syringe carrier, causing the c-shaped distal end region of the syringe carrier to flex radially outward; and
further axially advancing the syringe within the syringe carrier until a proximal end of the rigid needle shield is distal to the one or more projections, allowing the c-shaped distal end region of the syringe carrier to rebound radially inward such that the one or more projections are disposed in a gap formed between the rigid needle shield and the barrel of the syringe.

US Pat. No. 10,967,129

DOSING DEVICE

HOFFMANN-LA ROCHE INC., ...

1. A dosing device, comprising:a rod element having a stem with a longitudinal axis and a first thread arrangement; and
a shell having a second thread arrangement,
wherein,
the first thread arrangement of the rod element or the second thread arrangement of the shell comprises a thread,
the first thread arrangement of the rod element and the second thread arrangement of the shell engage,
the rod element is movable along the longitudinal axis of the stem by rotating the shell and the rod element relative to each other causing the first thread arrangement of the rod element and the second thread arrangement of the shell to travel along each other,
a dosage chamber is formed by moving the rod element along the longitudinal axis of its stem,
a volume of the dosage chamber is adapted by moving the rod element along the longitudinal axis of the stem, and
an inclination angle of the thread of the first thread arrangement of the rod element or the second thread arrangement of the shell varies along the thread of the first thread arrangement of the rod element or the second thread arrangement of the shell.

US Pat. No. 10,967,128

ADMINISTRATION MECHANISM FOR A MEDICAMENT DELIVERY DEVICE

SHL MEDICAL AG, Zug (CH)...

1. An administration mechanism for a medicament delivery device, comprising:a movable sleeve;
a delivery member cover having a distal end portion configured to receive the movable sleeve, and configured to be linearly displaceable between a first position and a second position relative to the movable sleeve, and
a first resilient member that biases the delivery member cover towards the first position,
wherein the distal end portion has an end face defining a guide surface and the movable sleeve has a radially outwards extending first follower structure configured to cooperate with the guide surface when the delivery member cover is moved from the first position towards the second position, causing the movable sleeve to move.

US Pat. No. 10,967,127

PHARMACEUTICAL INJECTION DEVICE

PHC HOLDINGS CORPORATION,...

1. A pharmaceutical injection device, comprising:a main body case having at a first end side an injection needle mounting portion to which an injection needle is mounted;
a pharmaceutical syringe mounting portion that is provided inside the main body case and to which a pharmaceutical syringe is mounted;
a piston that is provided movably with respect to the pharmaceutical syringe mounted to the pharmaceutical syringe mounting portion;
a drive mechanism configured to drive the piston;
a cover that covers the injection needle mounting portion disposed in an openable and closeable state, while the cover is still attached to the first end side of the main body case, and the cover is opened when the injection needle is mounted;
an opening and closing mechanism configured to open or close the cover to the injection needle mounting portion; and
a locking mechanism configured to restrict movement of the opening and closing mechanism so that the cover will not open when the pharmaceutical syringe mounting portion has been opened.

US Pat. No. 10,967,126

JOINING TECHNOLOGY OF A DISPENSE INTERFACE

Sanofi-Aventis Deutschlan...

1. A medical device configured to eject a medicament, the medical device comprising:a body part defining an inner body of the medical device; and
a cover part defining a manifold of the medical device, wherein the body part and the cover part are configured and dimensioned to at least partially form a fluid channel between a first surface of the body part and a first surface of the cover part, wherein the first surface of the body part and the first surface of the cover part are joined to each other and are at least substantially flat at a joining area that connects the body part and the cover part, and wherein the joining area is at least substantially parallel to a longitudinal axis of the medical device.

US Pat. No. 10,967,125

COMPOUNDING DEVICE SYSTEM

Omnicell, Inc., Mountain...

1. A system for compounding of medications, the system comprising:one or more compounding devices;
a computer, wherein each of the one or more compounding devices is in bidirectional communication with the computer via a communications network;
wherein the computer is configured to:
receive a plurality of requests, at least some of which require compounding of one or more medications; and
for each of the received requests, push, via the communications network, an assignment of a respective compounding task to one of the one or more compounding devices, wherein the computer is configured to assign respective compounding tasks in accordance with a set of rules designed to promote efficient use of compounding resources.

US Pat. No. 10,967,124

INFUSION PUMPS

MEDTRONIC MINIMED, INC., ...

1. An infusion pump system, comprising:a baseplate assembly comprising:
a baseplate;
a medicament cartridge on the baseplate defining a reservoir; and
a baseplate energy supply on the baseplate, the baseplate energy supply comprising a housing, an electrical energy storage device within the housing, and a pair of flexible electrical contacts respectively connected to an anode and a cathode of the electrical energy storage device, the baseplate energy supply configured to transfer energy to a replenishable energy supply of a reusable pump assembly when the baseplate assembly is coupled to the reusable pump assembly, the baseplate assembly being a disposable baseplate assembly;
a cannula; and
a cannula inserter.

US Pat. No. 10,967,123

SELF-INJECTION DEVICE

Becton, Dickinson and Com...

1. A device for delivering a medicament into a patient's body by injection into or through the patient's skin, comprising:a main body including a top enclosure and a bottom enclosure including a cylindrical housing;
a reservoir disposed within the main body for containing the medicament;
an injection needle for penetrating the skin of the patient, the needle having a lumen and selectively communicating with the reservoir; and
a pressurizing system for selectively pressurizing the reservoir, the pressurizing system comprising a plunger movable within the main body;
wherein:
in a pre-activated position, the pressurizing system is restrained within the cylindrical housing and the pressurizing system contacts and deforms the reservoir to reduce a fillable volume of the reservoir;
the plunger comprises at least one leg extending from an outer edge of the plunger, and a foot extending from the leg; and
the bottom enclosure comprises a retaining portion, wherein a frictional resistance between the foot and the retaining portion retains the pressurizing system in the pre-activated position against the force of the pressurization spring.

US Pat. No. 10,967,122

SUBCUTANEOUS DRUG DELIVERY DEVICE WITH MANUAL ACTIVATION AND DEACTIVATION OF DRUG RELEASE

Massachusetts Institute o...

1. An implantable device for drug delivery comprising:a housing which comprises a drug reservoir;
a drug formulation disposed in the drug reservoir, the drug formulation comprising a drug;
at least one aperture extending through a wall of the housing through which the drug can diffuse to release the drug from the device; and
a bistable member having a first stable state in which the member permits a fluidic pathway between the drug reservoir and the at least one aperture to be open to permit release of the drug by diffusion and a second stable state in which the member closes off the fluidic pathway to exclude release of the drug,
wherein the bistable member is manually reversibly and elastically formable between the first and second stable states.

US Pat. No. 10,967,121

ROTATIONAL METERING PUMP FOR INSULIN PATCH

BECTON, DICKINSON AND COM...

1. A rotational metering pump comprising:a manifold comprising a reservoir port in fluid communication with a fluid reservoir and a cannula port in fluid communication with a cannula;
a sleeve comprising a side hole, the sleeve adapted to rotate axially within the manifold between a first orientation with said side hole aligned with the reservoir port and a second orientation with said side hole aligned with the cannula port, the sleeve further comprising a helical groove having a first end and a second end;
a plunger comprising an overmolded seal molded over a plunger head adapted to rotate and translate axially within the sleeve, wherein axial translation of the plunger within the sleeve changes a pump volume, the pump volume being in fluid communication with the side hole of the sleeve, the plunger further comprising a coupling member adapted to move within the helical groove and between the first end and the second end of the helical groove to cause the plunger to translate axially within the sleeve as the plunger is rotated;
a motor adapted to rotate the plunger in a first direction causing the pump volume to increase when the sleeve is in the first orientation, and to rotate the sleeve and plunger together when the coupling member reaches the first end of the helical groove, such that the sleeve moves into the second orientation;
further comprising a rotational limit switch, the rotational limit switch causing the motor to reverse direction after the sleeve rotates to orient the side hole with the cannula port;
wherein the sleeve comprises an actuator arm fixed to the sleeve that moves a limit switch as the sleeve rotates in either direction, and wherein the limit switch is biased to return to a center position when the actuator arm rotates past the limit switch.

US Pat. No. 10,967,120

PORTABLE LIQUID DRUG DELIVERY DEVICE

Roche Diabetes Care, Inc....

1. A portable liquid drug delivery device comprising a reservoir part and a driving part having a drive that produces a torque, the reservoir part comprising:a reservoir configured for retaining a liquid drug;
an outlet port in fluid communication with the reservoir;
a threaded piston rod with a piston;
an engagement member having an inner thread configured to engage with the thread of the piston rod in an engaged position and configured to disengage from the thread of the piston rod in a disengaged position, the engagement member being prestressed in the disengaged position to thereby bias the engagement member toward the engaged position, the engagement member further configured to convert the torque of the drive into a linear movement of the piston rod when the engagement member is in the engaged position and wherein the engagement member does not convert the torque of the drive into linear movement of the piston rod when the engagement member is in the disengaged position, wherein the piston is configured, upon the linear movement of the piston rod, to deliver the liquid drug to the outlet port;
wherein the engagement member is a nut having two parts wherein the two parts of the nut clutch the piston rod in the engaged position and release the piston rod in the disengaged position and wherein each of the two parts of the nut has an arm; and
a handle, the handle being moveable from a blocking position between the arms of the nut to prevent movement of the two parts from the disengaged position to the engaged position and a retracted position allowing the two parts to move into the engaged position.

US Pat. No. 10,967,119

WEARABLE MEDICATION INJECTING DEVICE

1. A wearable medication injecting device for administering a medication to a patient, the patient having a limb and a skin surface, comprising:a detachable medication module having a medication housing, the medication housing having a medication housing first end, a medication housing interior space, and a medication housing second end, the detachable medication module further having a medication reservoir contained within the medication housing interior space adapted to store the medication, and a needle housing attached to the medication housing first end, the needle housing having a needle head movably engaged therein, the needle head is adapted to move vertically and has a needle which projects downwardly from the needle head and is adapted to penetrate the skin surface and deliver the medication therethrough, the detachable medication module further having a medication transport line adapted to transport the medication from the medication reservoir to the needle;
a medication injection assembly having a mounting panel having an upper face and an inner face adapted to be positioned against the skin surface, the mounting panel further having an injection aperture extending between the upper face and the inner face of the mounting panel, and an attachment point disposed on the upper face adapted to allow the detachable medication module to be detachably secured within, the medication injection assembly further having a needle actuation mechanism adapted to push the needle head downwardly and lower the needle towards the skin surface through the injection aperture, and an injection actuation mechanism adapted to expel the medication from the medication reservoir;
an elastic band adapted to secure the medication injection assembly in place against the limb;
a device control module adapted to control the needle actuation mechanism and the injection actuation mechanism, the device control module further having a wireless transceiver adapted for wireless communication; and
a user control device adapted to communicate wirelessly with the device control module and initiate a scheduled injection according to a dose schedule.

US Pat. No. 10,967,118

AUTOMATIC INJECTION DEVICE HAVING A MAGNETIC DRIVE SYSTEM

Flex, Ltd.

1. An automatic injection device, comprising:an insertion needle configured to be inserted into a patient;
a drug container configured to contain a pharmaceutical product, the drug container including a stopper;
a fluid path which fluidly connects the drug container to the insertion needle;
a drive system configured to cause linear movement of the stopper to force the pharmaceutical product into the fluid path, the drive system comprising a driving element and a movable element; and
electronics configured to provide signals to and receive signals from the drive system to move the stopper and monitor a position of the stopper;
wherein the movable element includes an outer magnet at least partially surrounding the drug container and an inner magnet inside the drug container,
wherein the driving element further comprises two shafts and two connectors, wherein movement of the two connectors along the two shafts move the outer magnet linearly and parallel along the outside of the drug container.

US Pat. No. 10,967,117

AUTOMATED INSERTION ASSEMBLY

DEKA PRODUCTS LIMITED PAR...

1. An automated insertion system comprising:a cartridge assembly comprising:
a toothed track;
a toothless track; and
at least one dermal perforation assembly having an interior passage configured to releasably engage at least a portion of a subdermal device therein; and
an actuation assembly configured to drive the at least one dermal perforation assembly a predetermined distance, the actuation assembly comprising:
a drive gear set comprising an uppermost gear, the drive gear set for engaging the cartridge assembly;
an actuator; and
a torsion spring,
wherein when the uppermost gear of the drive gear set is engaged with the toothed track of the cartridge assembly, the actuator is configured to be raised and the torsion spring is configured to be wound, and
wherein after the at least one dermal perforation assembly is driven the predetermined distance, the uppermost gear of the drive gear set is seated in the toothless track.

US Pat. No. 10,967,116

INFUSION LINE SYSTEMS

MEDLITE ID INC., St. Geo...

1. An intravenous (IV) infusion line assembly, comprising:an elongated member having a fluid conduit for administering therapeutic fluid to a patient, the fluid conduit configured to provide fluid communication between a first end of the elongated member and a second end of the elongated member; and
an optical member disposed along a longitudinal length of the elongated member between the first end and the second end of the elongated member, wherein the optical member is at least partially optically transmissive to internally reflect light within the optical member,
wherein the optical member is affixed along the longitudinal length of the elongated member by a partial melting between the optical member and the longitudinal length of the elongated member.

US Pat. No. 10,967,115

TOXIN SEPARATOR

Kureha Corporation, Toky...

7. A toxin separation method of separating toxin from a biological fluid,wherein the toxin is bound to protein to be present in the biological fluid, and
the method includes passing the biological fluid through the toxin separator described in claim 1.

US Pat. No. 10,967,114

DIALYSIS MACHINE

FRESENIUS MEDICAL CARE DE...

1. A dialysis machine comprising:an extracorporeal blood circuit, a blood pump, a dialyzer, a venous pressure sensor, a substituate line, and a control unit,
the control unit being configured to operate the blood pump in a first operating mode and in a special operating mode, and to start the special operating mode after recognition of a trigger event,
with, in the special operating mode, a conveying rate of the blood pump being controlled via a default value, or being regulated to a desired value, the default value or the desired value being derived from a value determined before the start of the started special operating mode or corresponding to said value,
the control unit being configured to poll a presence of an obstacle before the start of the special operating mode, the obstacle including a specific waiting period, a duration of which has not been achieved, after a start or an elapse of a phase which is deployed earlier in time and in which the blood pump is operated in the special operating mode, and
on a determination of the presence of the obstacle, to at least one of (i) block or delay the start of the special operating mode and (ii) make the selection of the default value or of the desired value on the presence of the obstacle differ from the selection without the presence of the obstacle.

US Pat. No. 10,967,113

DIALYSATE-EXTRACTING APPARATUS

Nikkiso Company Limited, ...

1. A dialysate-extracting apparatus comprising:a dialysate-extracting device having an introduction port and a discharge port each of which is configured to be connected to a flow route for liquid and allows the liquid to flow through the dialysate-extracting device, and a collecting port from which the liquid flowing in the flow route is collectable; and
an opening-and-closing device that is movable between a closing position where the opening-and-closing device covers the collecting port of the dialysate-extracting device and an opening position where the opening-and-closing device opens the collecting port;
a sealing unit that seals the collecting port, the sealing unit comprising:
a seal member provided around a peripheral edge of the collecting port; and
a core member that seals the collecting port when coming into contact with the seal member and allows the liquid to be collected from the collecting port when the core member is moving away from the sealing member;
an ultraviolet-applying device attached to the opening-and-closing device and that is capable of applying ultraviolet rays to the collecting port when the opening-and-closing device is at the closing position; the ultraviolet-applying device is capable of applying ultraviolet rays to the sealing unit; and the ultraviolet-applying device is capable of applying ultraviolet rays to the seal member and to the core member;
wherein the core member is capable of transmitting the ultraviolet rays emitted from the ultraviolet-applying device or reflecting the ultraviolet rays around the core member;
wherein the core member includes an adjusting portion that is capable of adjusting the reflection or transmission of the ultraviolet rays emitted from the ultraviolet-applying device;
wherein the core member has a projection with an arc-shaped surface that serves as the adjusting portion;
wherein the arc-shaped surface is configured to be adjustable so that an angle of the reflection or transmission of the ultraviolet rays relative to the ultraviolet-applying device are refracted at a predetermined angle and wherein the arc-shaped surface is further configured to apply the ultraviolet rays to one or more desired sites around the core member.

US Pat. No. 10,967,112

ADAPTIVE SYSTEM FOR BLOOD FLUID REMOVAL

Medtronic, Inc., Minneap...

1. A method carried out by a blood fluid removal system, comprising:initiating a blood fluid removal session, using a blood fluid removal device, with initial system parameters;
acquiring a first set of data regarding one or more patient physiological parameters, wherein the one or more patient physiological parameters include at least one of pH and concentration of an electrolyte wherein at least one patient physiological parameter is measured in a dialysate;
storing the first data set in a most effective to date data set memory;
associating the initial system parameters in an increased effectiveness lookup table with the first data set;
adjusting at least one parameter of the blood fluid removal session by adjusting the dialysate to arrive at adjusted system parameters;
acquiring a second set of data regarding the one or more patient physiological parameters after the at least one parameter of the blood fluid removal session has been adjusted; and
determining which of the first and second set of data includes at least one value closer to a target value; storing in the increased effectiveness lookup table data regarding the data set having at least one value closer to the target value; and associating data regarding the adjusted system parameters with the data set having at least one value closer to the target value; and
repeating the process beginning with acquiring a first set of data regarding one or more patient physiological parameters;
storing the first data set in a least effective to date data set memory;
associating the initial system parameters in a decreased effectiveness lookup table with the first data set prior to adjusting the at least one parameter of the blood fluid removal session;
determining which of the first and second set of data includes at least one value further from the target value; storing in the decreased effectiveness lookup table data regarding the data set having at least one value further from the target value; and associating data regarding the adjusted system parameters with the data set having at least one value further from to the target value;
replacing the data in the least effective to date data set with the data from the data set having at least one value further from the target value; and
continuing the blood fluid removal session with the system parameters in the most effective to date data set;
wherein the blood fluid removal system performs at least one blood fluid removal process selected from the group consisting of ultrafiltration, hemofiltration, hemodialysis, hemodiafiltration and peritoneal dialysis.

US Pat. No. 10,967,111

BLOOD TREATMENT FILTER AND BLOOD BAG SYSTEM

Terumo Kabushiki Kaisha, ...

1. A blood treatment filter configured to remove a predetermined blood component from blood, the blood treatment filter comprising:a housing including a first resin sheet and a second resin sheet constituting walls opposite each other;
a filter member provided between the first resin sheet and the second resin sheet forming a partition in the interior of the housing into a blood inflow chamber and a blood outflow chamber, the filter member including at least one filtering material;
an inflow port in communication with the blood inflow chamber;
an outflow port in communication with the blood outflow chamber;
a peripheral edge molded body configured to surround a peripheral edge portion of the filter member over its entire circumference, the peripheral edge molded body including an inner peripheral edge portion joined to an outer peripheral end edge of the filtering material; and
a connection sheet connecting the peripheral edge molded body to the housing.

US Pat. No. 10,967,109

DRESSING WITH DIFFERENTIALLY SIZED PERFORATIONS

KCI Licensing, Inc., San...

1. A dressing for treating a tissue site, comprising:a base layer having a periphery surrounding a central portion and a plurality of apertures disposed through the periphery and the central portion;
an adhesive configured to extend through the apertures in at least the periphery of the base layer to contact tissue surrounding the tissue site, at least one of the apertures in a corner of the periphery of the base layer being configured to expose more of the adhesive for contact with the tissue than other apertures in the periphery of the base layer;
a sealing member having a periphery and a central portion, the periphery of the sealing member positioned proximate to the periphery of the base layer, wherein the central portion of the sealing member and the central portion of the base layer define an enclosure; and
at least one wicking layer disposed in the enclosure.

US Pat. No. 10,967,108

LOW-PROFILE REDUCED PRESSURE TREATMENT SYSTEM

KCI Licensing, Inc., San...

1. A process for treating a tissue site, the process comprising:positioning a first flexible membrane so that an overlay zone is adjacent to the tissue site and a conduit holder is adjacent to the overlay zone opposite the tissue site;
adhesively connecting the first flexible membrane to a bottom surface of the conduit holder;
positioning a porous pad so that a bridge region is aligned with the overlay zone and a primary delivery region is aligned with the tissue site;
connecting the porous pad to a reduced pressure source through a conduit in the conduit holder;
positioning a second flexible membrane over the conduit holder and the porous pad;
sealing the second flexible membrane to a tissue contact region; and
applying reduced pressure from the reduced pressure source to the tissue site through the conduit and the porous pad.

US Pat. No. 10,967,107

SUCTION AND IRRIGATION DEVICE

Entellus Medical, Inc., ...

1. An irrigation and suction device for irrigating and suctioning fluid from a body lumen or a body cavity of a patient comprising:an irrigation tube that defines an irrigation lumen;
a suction tube slidably mounted on the irrigation tube, wherein an outer wall of the irrigation tube and an inner wall of the suction tube cooperatively define a suction channel, wherein a distal tip of the suction tube and the outer wall of the irrigation tube define an aperture for receiving the fluid into the suction channel from the body lumen or the body cavity;
a handle coupled to a proximal portion of the irrigation tube; and
a slide member slidably mounted within the handle,
wherein the slide member is coupled to the suction tube such that advancing the slide member along the handle advances a distal tip of the suction tube along a length of the irrigation tube,
wherein the distal tip of the suction tube is movable between a distal position and a proximal position relative to the irrigation tube,
wherein, at all positions of the distal tip of the suction tube between the distal position and the proximal position, the handle is configured to fluidly couple the suction channel to a suction source, and
wherein, at all positions of the distal tip of the suction tube between the distal position and the proximal position, the irrigation tube is configured to irrigate the body lumen or the body cavity with a fluid.

US Pat. No. 10,967,106

WOUND THERAPY SYSTEM AND RELATED METHODS THEREFOR

1. A system for negative pressure therapy in connection with healing a wound, the system comprising:a wound dressing for positioning relative to a wound;
a negative pressure mechanism comprising a housing having a control unit and configured to draw a vacuum; and
a canister associated with the housing, the canister comprising:
a chamber and a collection bag disposed within the chamber, the collection bag configured to be in fluid communication with the wound dressing to receive exudates from the wound, the collection bag configured to expand upon receipt of the exudates, wherein the collection bag comprises an absorbent material configured to contain exudates removed from the wound.

US Pat. No. 10,967,105

MEDICAL DEVICES AND INSTRUMENTS WITH NON-COATED SUPERHYDROPHOBIC OR SUPEROLEOPHOBIC SURFACES

1. A medical instrument adapted for use with an intraocular procedure, comprising:a proximal portion configured for grasping by a user;
a distal portion including an elongated shaft terminating in a distal tip adapted for use in conjunction with an intraocular procedure;
wherein the distal portion is made from a base material having a surface adapted for contact with biological intraocular vitreous material; and
wherein the surface of the distal portion of the instrument includes micrometer- or nanometer-sized structures or patterns made only from the base material, causing the distal portion of the instrument to become superhydrophobic, superoleophobic, or both, thereby causing the distal portion of the instrument to repel the vitreous material during the intraocular procedure.

US Pat. No. 10,967,104

ENCAPSULATED OR COATED STENT SYSTEMS

PETVIVO HOLDINGS, INC., ...

1. A single strand stent system comprising a single strand twisted to form a loop strut or two or more rounded loops said loop strut or loops coated or encapsulated with a biocoacervate material comprising one or more primary proteins, one or more secondary proteins, one or more proteoglycans, and one or more biocompatible solvents, wherein the biocoacervate material is crosslinked with one or more crosslinking agents, wherein the biocoacervate material comprises a thermoplastic biocoacervate material configured to be remelted and reformed into a desired shape and size prior to being crosslinked with the one or more crosslinking agents.

US Pat. No. 10,967,103

SYSTEMS AND METHODS FOR SELECTIVE COATING REMOVAL FOR RESORBABLE METAL MEDICAL DEVICES

UNIVERSITY OF PITTSBURGH-...

1. A medical implant device, comprising:a substrate selected from the group consisting of magnesium and magnesium alloy, having a first surface and an opposing second surface;
a thin film coating applied to at least one of the first and second surfaces, comprising:
a self-assembled amphiphilic organosilane having a hydrophobic aliphatic tail containing a C4 to C20 backbone, and a hydrophilic silane head reactive with the substrate, comprising:
an alkyltrialkoxy silane tetramethoxysilane co-polymer;
a cross-linking agent combined with the co-polymer; and
an aminosilane binding compound; and
a pattern applied to the thin film coating in a form such that one or more selected areas of the substrate is uncoated.

US Pat. No. 10,967,102

CELL ENCAPSULATION MEMBRANES, DEVICES AND METHODS

Boston Scientific Limited...

1. A cell encapsulation membrane comprising:a mesh substrate, the mesh substrate comprising
a first series of fibers extending in a first direction and
a second series of fibers extending in a second direction,
the first series of fibers intersecting with the second series of fibers,
the mesh substrate defining a plurality of apertures disposed between adjacent fibers of the first series and the second series;
a coating disposed on the mesh substrate, the coating partially occluding the plurality of apertures defined by the mesh substrate, the coating forming pores disposed in a repeating pattern at the center of each aperture.

US Pat. No. 10,967,101

METHOD AND APPARATUS FOR DIVERTING SWEAT, LIQUID, MOISTURE, OR THE LIKE FROM AN EYE

1. A method for maintaining visual clarity of a human wearer by diverting perspiration that rolls down a forehead of the human wearer away from an eye of the human wearer to a side of the human wearer's face with a perspiration diverting apparatus that is configured to be worn entirely above an upper eyelid of the eye, the perspiration diverting apparatus configured as a substrate having a bottom section shaped to conform to a contour of an upper orbit of the eye above the eye of the human wearer, one portion of the bottom section having an adhesive inner surface for releasable attachment to the upper orbit of the eye below an eyebrow and entirely above the upper eyelid of the eye of the human wearer, and an upper section free of adhesive, visual clarity of the human wearer is maintained when the perspiration diverting apparatus is worn by the human wearer, said method comprising:adhering the perspiration diverting apparatus to an area above the upper eyelid and below the eyebrow of the human wearer via the adhesive inner surface disposed on the one portion of the bottom section of the substrate such that the upper section extends upward from the bottom section and away from skin of the human wearer to create a gutter directly below or along the eyebrow of the human wearer to the side of the face of the human wearer and such that an entirety of the perspiration diverting apparatus resides above the upper eyelid and at or below the eyebrow of the human wearer; and
collecting perspiration that rolls down the forehead of the human wearer in the gutter to cause the gutter to divert the collected perspiration along the gutter to the side of the face of the human wearer.

US Pat. No. 10,967,097

METHODS OF MAKING CHITOSAN/HYALURONIC ACID HYDROGEL COMPOSITIONS AND COMPOSITIONS MADE THEREFROM

Oceanit Laboratories, Inc...

1. A hydrogel preparation method, comprising:creating a chitosan suspension in water;
adjusting pH of the chitosan suspension to between 4.7 and 7.5 to dissolve the chitosan and form a chitosan solution;
combining first buffer salts with the chitosan solution;
combining hyaluronic acid (HA) and second buffer salts in water and creating an HA solution with a pH of between 4.5 and 6.5;
adding carbodiimide coupling and activating reagents to the HA solution, thereby creating an activated HA solution;
adding the chitosan solution to the activated HA solution to form a resulting mixture; and
allowing the resulting mixture to set to form a hydrogel.

US Pat. No. 10,967,096

TISSUE SEALANT COMPOSITIONS, VASCULAR CLOSURE DEVICES, AND USES THEREOF

MediBeacon Inc., St. Lou...

1. A method of forming a seal in a biological tissue, the method comprising:administering to a subject an effective amount of a tissue sealant to the biological tissue; and
activating an adhesive material in the tissue sealant, thereby forming the seal in the biological tissue;
wherein the tissue sealant comprises:
an adhesive material that is activated to form a seal when contacted with the biological tissue; and
an optical dye covalently bonded to, or noncovalently associated with, the adhesive material;
wherein the optical dye exhibits a first optical condition prior to activation of the adhesive material and exhibits a second optical condition distinguishable from the first optical condition after activation of the adhesive material.

US Pat. No. 10,967,095

WOUND DRESSINGS AND PREPARATION THEREOF

AMIRKABIR UNIVERSITY OF T...

1. A method for preparing a wound dressing, comprising:forming a first solution by mixing a zinc solution with a first portion of a tragacanth solution;
immersing a substrate in the first solution;
forming a second solution by adjusting potential of hydrogen (pH) of the first solution containing the substrate;
forming a modified substrate by synthesizing a plurality of zinc oxide (ZnO) nanoparticles with a particle size between 55 nm and 70 nm on the substrate by applying ultrasound radiation to the second solution; and
forming a plurality of ammoniacum nanocapsules with a particle size between 20 nm and 80 nm utilizing the modified substrate, wherein forming the plurality of ammoniacum nanocapsules comprises:
forming a first microemulsion by adding an emulsifier to a mixture of ammoniacum extract and an oil;
forming a second microemulsion by adding a second portion of a tragacanth solution to the first microemulsion;
immersing the modified substrate in the second microemulsion;
adding a cross-linking agent to the second microemulsion containing the modified substrate; and
applying ultrasound radiation to the second microemulsion containing the modified substrate and the cross-linking agent.

US Pat. No. 10,967,094

PURIFIED HYDROGEN PEROXIDE GAS GENERATION METHODS AND DEVICES

Synexis LLC, Overland Pa...

1. A device for producing non-hydrated purified hydrogen peroxide gas (PHPG) comprising:a. an enclosure;
b. an air distribution mechanism providing an airflow;
c. an air-permeable substrate structure that is a mesh having a percentage of open area between 10% and 60%, said mesh having a catalyst on its surface;
d. a source of light; and
wherein said airflow is through said air-permeable substrate structure; and
said device produces PHPG and directs it out of said enclosure when in operation.

US Pat. No. 10,967,093

PATHOGEN MITIGATION

1. A process for mitigating indoor pathogens, the process comprising:identifying a first occurrence of at least one pathogen in an indoor environment by measuring the first occurrence of at least one pathogen in the indoor environment;
determining that the indoor environment is contaminated based upon the identification of the first occurrence of at least one pathogen;
removing the first occurrence of at least one pathogen by sanitizing the indoor environment where the first occurrence of at least one pathogen is located responsive to the determined contamination;
installing a purification unit in a suitable location to mitigate pathogens within the indoor environment after sanitizing the indoor environment, where a selection of a type of the purification unit is based upon the identification of the first occurrence of at least one pathogen;
monitoring the indoor environment for a second occurrence of pathogens by continuously measuring the pathogens in the indoor environment; and
assessing the purification unit to determine maintenance needs of the purification unit.

US Pat. No. 10,967,092

DIFFUSER FOR ESSENTIAL OILS

Greenair Inc., Westlake,...

1. A diffuser, comprising:a housing having at least one inlet, and at least one vent outlet;
a microblower carried by said housing, said microblower having an inlet side to receive air from said at least one inlet and an outlet port;
a bottle adapted to carry essential oil, said bottle having a neck opening;
a tube directing air from said microblower outlet port into said neck opening to generate oil-laden air; and
a fan drawing ambient air in from said at least one inlet and exhausting ambient air and oil-laden air through said at least one vent outlet.

US Pat. No. 10,967,091

SCENT DISPENSATION

Pura Scents, Inc., Orem,...

1. A solution dispensing apparatus, comprising:a body including a first vial bay and a second vial bay, the first vial bay and the second vial bay being adjacently situated;
a first heating element disposed in the body in association with the first vial bay;
a second heating element disposed in the body in association with the second vial bay;
a vial retaining mechanism including a first vial coupling proximate the first vial bay, and a second vial coupling proximate the second vial bay and the second heating element, the first vial coupling configured to receive and detachably retain a first vial and situate a dispensing end of the first vial toward the first heating element, and the second vial coupling configured to receive and detachably retain a second vial and situate a dispensing end of the second vial toward the second heating element;
a switching mechanism including the first heating element associated with the first vial bay, and the second heating element associated with the second vial bay, wherein:
the first heating element is configured to heat a first solution dispensed from the dispensing end of the first vial, and
the second heating element is configured to heat a second solution dispensed from the dispensing end of the second vial;
a wireless interface configured to wirelessly communicate with a management server to receive control data stored on the management server, the control data including solution settings from the management server based on an association of the solution dispensing apparatus with a particular room; and
a controller electronically coupled to the wireless interface to receive the control data and electronically coupled to the switching mechanism, the controller configured to instruct the switching mechanism to dispense one or more of the first solution from the first vial via the first heating element and the second solution from the second vial via the second heating element based on the solution settings received from the management server and an attribute of the particular room.

US Pat. No. 10,967,090

ELECTRONIC SCENTED CANDLE AND FRAGRANCE CONTAINER

1. An electronic scented candle, comprising:a shell;
a flame element resembling a real candle flame;
a fragrance container positioned within the shell;
a scent chamber coupled to the fragrance container via a liquid suction channel positioned within the fragrance container, the liquid suction channel having a first end that protrudes from the fragrance container into the scent chamber and a second end having an opening positioned inside the fragrance container to allow a fragrance material to be drawn from the fragrance container to the scent chamber;
an air inlet connected to the scent chamber to allow air to be directed into the scent chamber;
a heater configured to provide thermal energy to the scent chamber to vaporize part of the fragrance material in the scent chamber; and
a scent outlet connected to the scent chamber to allow the vaporized fragrance material to leave the scent chamber.

US Pat. No. 10,967,089

DEODORIZING GLOVE HOLDER FOR ATHLETIC GLOVES AND OTHER EQUIPMENT

1. A device for insertion within sports equipment comprising:an enclosure having ventilation holes and at least one removable cap, said enclosure being comprised of rigid plastic that is infused with antimicrobial ions and configured without lateral extensions that restrict the enclosure from contacting an internal surface of the sports equipment when inserted into the sports equipment;
a removable insert displaced within said enclosure, said insert including a moisture absorbing deodorizer.

US Pat. No. 10,967,088

METHOD OF CALCULATING AN EXPOSURE TIME FOR DISINFECTING A ROOM USING AN ULTRAVIOLET DISINFECTING APPARATUS

FINSEN TECHNOLOGIES LIMIT...

1. A method of calculating an exposure time for disinfecting a room using an ultraviolet disinfecting apparatus,the method comprising the steps of:
measuring distances by:
a) using a spatial sensor on the ultraviolet disinfecting apparatus, to perform a first scan of a boundary surface of the room, to measure a first set of distances from the sensor to the boundary surface;
b) adjusting the height of the spatial sensor;
c) using the spatial sensor to perform a second scan of the boundary surface of the room, to measure a second set of distances from the adjusted sensor to the boundary surface;
d) further adjusting the orientation of the spatial sensor; and
e) using the spatial sensor to perform a third scan of the boundary surface of the room, to measure a third set of distances from the further-adjusted sensor to the boundary surface;
and subsequently calculating the exposure time in dependence on the sets of distances.

US Pat. No. 10,967,087

STERILIZER WITH A HUMIDITY CONTROL SYSTEM

3M Innovative Properties ...

1. A sterilizer for sterilizing objects comprising:a chamber for receiving objects to be sterilized;
a humidity control system comprising:
a water control system which can be connected to a water source for injecting a first quantity of water vapor into the chamber;
a pressure sensor in fluid communication with the chamber for measuring pressure in the chamber;
a humidity sensor in fluid communication, or in selective fluid communication, with the chamber for sensing a first humidity value (RHchamber) of the first quantity of water vapor in the chamber; and
a controller configured to inject a second quantity of water vapor into the chamber, wherein the controller is configured to:
determine a pressure drop and a pressure rise in the chamber resulting from the first quantity of water vapor injected into the chamber,
calculate an absorption ratio (AR) as the ratio of the pressure drop to the pressure rise,
compare the first humidity value (RHchamber) to a pre-selected humidity value (RHsetpoint) to determine a humidity error (RHerror), wherein RHerror=RHsetpoint?RHchamber, and
determine a second quantity of water vapor to be injected into the chamber based on the absorption ration (AR) and the humidity error (RHerror).

US Pat. No. 10,967,086

SILVER NANOPARTICLE-ENHANCED PHOTOSENSITIZERS AS ANTIBIOFILM AGENTS

University Of Cincinnati,...

1. A method of killing a biofilm comprising:contacting a biofilm with a nanostructure comprising a silver nanoparticle core, a mesoporous silica shell, and a photosensitizer to form a blend; and
exposing said blend to light.

US Pat. No. 10,967,085

APPARATUS AND METHOD FOR DISINFECTING ENTITIES

Project Pure Life LLC, N...

1. A method for reducing viral or bacterial spread and increasing security of a premises via a housing including disinfecting dispensers and motion, metal and temperature sensors, comprising the steps of:(a) sensing motion when an individual approaches the threshold of the housing;
(b) automatically measuring and displaying the temperature of the individual at the threshold of the housing;
(c) prompting the individual to enter the housing;
(d) at least one of detecting metal near the individual when the individual enters the housing and operating a millimeter wave scanner to detect concealed objects of the individual after the individual has entered the housing;
(e) releasing an atomized fluid disinfectant on the individual for a defined period after the individual has entered the housing; and
(f) prompting the individual to exit the housing after the individual has remained in the housing for the defined period.

US Pat. No. 10,967,084

FLOW RESTRICTOR

ASP GLOBAL MANUFACTURING ...

1. An apparatus, comprising:a dry booster; and
a flow restrictor including
a first tube having a first tube inlet, a first tube outlet, a first tube length, and a first tube radius, and
a second tube having a second tube inlet, a second tube outlet, a second tube length, and a second tube radius;
wherein the first tube outlet and second tube outlet are connected to the dry booster, such that a fluid that is flowed through the flow restrictor flows separately through the first tube and the second tube.

US Pat. No. 10,967,083

ETHYLENE OXIDE ADSORPTION TOWER AND RECOVERY SYSTEM, AND METHOD FOR RECOVERING ETHYLENE OXIDE

Chio Kang Medical, Inc., ...

1. An ethylene oxide adsorption tower, comprising:a tower body defining a gas channel extending longitudinally therein, the tower body further comprising a sidewall, wherein the sidewall further comprises a plurality of mounting holes disposed longitudinally along the sidewall and in communication with the gas channel, wherein a bottom portion of the tower body includes a first pipe in communication with the gas channel, and a top portion of the tower body includes a second pipe in communication with the gas channel;
a plurality of adsorption panels, wherein each of the plurality of adsorption panels is coupled to the tower body through a corresponding respective mounting hole of the plurality of mounting holes, wherein each of the plurality of adsorption panels extends into the gas channel; and
a sealing door movably coupled to the sidewall of the tower body and configured to selectively fix each of the plurality of adsorption panels to a respective mounting hole of the plurality of mounting holes, wherein the sealing door comprises a door plate and sealing strip, wherein the sealing strip is arranged between the door plate and the tower body to create an outline corresponding to each of the plurality of adsorption panels to create a seal with the tower body and around each of the plurality of adsorption panels.

US Pat. No. 10,967,082

METHOD OF LIMITING THE SPREAD OF NOROVIRUS WITHIN A CRUISE SHIP

PARASOL MEDICAL, LLC, Bu...

1. A method of limiting spread of norovirus within a cruise ship comprising:documenting an existence of gastroenteritis among passengers of a cruise ship;
identifying a surface within a common area of the cruise ship that passengers are likely to touch and spread norovirus; and
applying, to the surface and to help prevent the spread of norovirus, a solution comprising a silane quaternary ammonium ion or salt thereof and isopropyl alcohol as solvent, the silane quaternary ammonium ion or salt being 3-(trimethoxysilyl)propyldimethyloctadecyl ammonium ion, 3-(trimethoxysilyl)propyldimethyloctadecyl ammonium chloride, 3-(trihydroxysilyl)propyldimethyloctadecyl ammonium ion, or 3-(trihydroxysilyl)propyldimethyloctadecyl ammonium chloride;
wherein, the isopropyl alcohol is between 55 percent and 65 percent by weight of the solution.

US Pat. No. 10,967,081

UV GERMICIDAL DEVICES, SYSTEMS, AND METHODS

UV Partners, Inc., Grand...

1. A system for disinfecting one or more surfaces, comprising:a plurality of germicidal devices, wherein each germicidal device comprises a germicidal light source including a processor for controlling disinfection cycles and a sensor capable of detecting a person is within an illumination area of the germicidal light source and interrupting a disinfection cycle by shutting off the germicidal light source, wherein each germicidal device is configured to automatically transmit disinfection cycles data representative of the number of completed disinfection cycles and completeness of partially completed disinfection cycles;
a server communicatively coupled to the plurality of germicidal devices via a network, wherein the server is configured to assign different disinfection protocols from among a plurality of disinfection protocols to subsets of the plurality of germicidal devices, provide instructions to the plurality of germicidal devices via the network to control the plurality of germicidal devices according to their assigned disinfection protocols, and collect disinfection cycles data from each of the plurality of germicidal devices via the network;
an administrator device communicatively coupled to the server, wherein the administrator device comprises an administrator interface, and wherein the administrator device is configured to receive input via the administrator interface and to provide instructions via the network; and
wherein, in response to the instructions transmitted via the network from the administrator device, at least one germicidal device of the plurality of germicidal devices adjusts one or more germicidal device operational parameters.

US Pat. No. 10,967,080

LIQUID FILLED LIGHT DISTRIBUTOR AND A METHOD OF USE

UV Clinical APS, Greve (...

1. A liquid filled light distributor comprising:a flexible elongated tubular body with a tube wall defining a closed inner lumen filled with a liquid, said flexible elongated tubular body having:
a proximal end closed by a first closure and
a distal end closed by a second closure, the first and second closures defining the closed inner lumen along the full length of the flexible elongated tubular body;
a volume of the liquid contained within the closed inner lumen between the first and second closures such that said volume of the liquid is retained within the closed inner lumen; and
a connector piece arranged to be in optical communication with a light source, the proximal end of the flexible elongated tubular body closed by the first closure configured to fit into the connector piece;
wherein the refractive index of the tube wall is n2, the refractive index of the liquid is n1, and n2/n1<1 so that light from the light source travels along the longitudinal direction of the flexible elongated tubular body and that a part of the light is emitted through the tube wall along at least a part of the flexible elongated tubular body,
wherein the volume of the liquid is a transparent ionic solution,
whereby the liquid filled light distributor provides illumination external to the liquid filled light distributor in a 360° radial distribution over at least a part of the length of the flexible elongated tubular body, and
wherein the tube wall has a thickness of less than 0.15 mm.

US Pat. No. 10,967,079

STERILIZATION TRAY

Zuno Medical, Inc., San ...

19. An apparatus for sterilizing surgical implements within a sterilization chamber and storing the sterilized surgical implements prior to use, the apparatus comprising:a container configured to receive one or more surgical implements;
a trap door coupled with the container so as to be reconfigurable between a closed configuration in which the trap door and the container at least partially define an internal volume that is hermetically sealed and an open configuration in which the trap door is displaced from the container to form a fluid passage between the internal volume and an external volume within the sterilization chamber and external to the container;
an electrical sensor housed in or on the container and configured to detect changes to a pressure state within the container;
a mechanism operatively coupled with the trap door and the container, the mechanism being configured for selective reconfiguration of the trap door from the closed configuration to the open configuration and to automatically reconfigure the trap door from the open configuration to the closed configuration in response to the pressure state detected by the sensor as present in the internal volume, the mechanism comprising an electromagnetic actuator configured to at least one of push the trap door toward the closed configuration or push the trap door toward the open configuration; and
an electrical indicator operable, based at least in part on information from the electrical sensor, to indicate if a pressure state within the container has changed since the apparatus automatically reconfigured the trap door from the open configuration to the closed configuration.

US Pat. No. 10,967,078

RADIOLABELLED MGLUR2 PET LIGANDS

JANSSEN PHARMACEUTICA NV,...

1. A compound having the Formula (P-3):

US Pat. No. 10,967,075

BIOMEDICAL MATERIALS

UNIVERSITY COURT OF THE U...

1. A process for the synthesis of a calcium phosphate-based material comprising gadolinium and silicon, the process comprising:providing calcium or a calcium-containing compound, a gadolinium-containing compound, a phosphorus-containing compound and a silicon-containing compound; and
forming a precipitate by reacting the compounds in an aqueous phase at an alkali pH;
thereby synthesizing a calcium phosphate-based material comprising gadolinium, wherein at least some of the gadolinium is in the form of Gd3+ ions substituted in the calcium phosphate lattice, and wherein the material comprises a compound having the general chemical formula:
Ca10?yGdy(PO4)6?x(SiO4)x(OH)2?x+y
wherein 0.5

US Pat. No. 10,967,071

DRUG-CONJUGATES, CONJUGATION METHODS, AND USES THEREOF

Concortis Biosystems, Cor...

1. An active agent-conjugate comprising Formula Ia:
or a pharmaceutically acceptable salt thereof,
wherein:
the A-component is an antibody or an antibody fragment;
the E-component is selected from the group consisting of:

L3 is an optionally substituted C1-C6 alkyl, or L3 is null, wherein when L3 is null the sulfur is directly connected to the E-component;
L4 is an optionally substituted C1-C6 alkyl, or L4 is null, wherein when L4 is null the sulfur is directly connected to the E-component;
B is a hydrophilic polymer, a biodegradable polymer, a polyamino acid, a polypeptide, a polysaccharide, a monoclonal antibody, an antibody fragment, a protein ligand, a protein scaffold, a peptide, or a nucleic acid, or B is null;
each D is independently selected, wherein each D includes an active agent which is a chemotherapy drug, tubulin-binder, DNA alkylating agent, HSP90 inhibitor, a DNA topoisomerase inhibitor, an HDAC inhibitor, a proteasome inhibitor, epothilone A, epothilone B, a cytotoxic peptide or paclitaxel;
each L2 is independently a linker, wherein L2 links to E; and
n is 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10.

US Pat. No. 10,967,069

BIO-ORTHOGONAL DRUG ACTIVATION

TAGWORKS PHARMACEUTICALS ...

1. A drug-dienophile conjugate of formula (1a):
which comprises a drug DD and a dienophile moiety;
wherein T and G each independently denotes H, or a substituent selected from the group consisting of alkyl, F, Cl, Br or I;
A and P each independently are CRa2 or CRaXD, provided that at least one is CRaXD; XD is (O—C(O))p-(LD)n-(DD), S—C(O)-(LD)n-(DD), O—C(S)-(LD)n-(DD), S—C(S)-(LD)n-(DD) wherein p=0 or 1; LD is a self-immolative linker; n=0 or 1; each DD independently is a drug;
Y, Z, Q, X together form a four-membered aliphatic or heteroaliphatic moiety, optionally fused to an aromatic moiety or moieties;
each Ra independently is selected from the group consisting of H, alkyl, aryl, OR?, SR?, S(?O)R??, S(?O)2R??, S(?O)2NR?R?, F, Cl, SO3H, SO4H, NO2, CN, CF3, CF2—R?, NR?R?, C(?O)R?, C(?O)OH, C(?O)NR?R?, C(?S)NR?R?, NR?C(?O)—R??, NR?C(?S)—R??, NR?C(?O)O—R??, NR?C(?S)O—R??, NR?C(?O)S—R??, OC(?O)NR?—R??, SC(?O)NR?—R??, OC(?S)NR?—R??, SC(?S)NR?—R??, NR?C(?S)S—R??, NR?C(?O)NR?—R?, and NR?C(?S)NR?—R?, with each R? and each R? independently being H, aryl or alkyl and R?? independently being aryl or alkyl;
wherein LD is linked to RT via S, N, NH, or O, wherein these atoms are part of the linker;
wherein DD is one or more drugs, linked to LD, O—C(O), S—C(O), O—C(S), S—C(S) or CRa via S, N, NH, or O, wherein these atoms are part of the drug; and wherein when XD is (O—C(O))p-(LD)n-(DD) and p=0 and LD or DD is bound to TR via N or NH, these N and NH moieties are bound to an aromatic carbon of LD or DD; and
wherein optionally one or more targeting agents TT or masking moieties MM are attached to the Drug DD, the dienophile moiety, or Linker LD, optionally via a spacer or spacers SP.

US Pat. No. 10,967,068

STABILITY-MODULATING LINKERS FOR USE WITH ANTIBODY DRUG CONJUGATES

PFIZER INC., New York, N...

1. A compound of Formula (III):
or a pharmaceutically acceptable salt or solvate thereof;
wherein:
M is a stability modulator -M1-M2, where M1 is —NR1—C(O)—, —NR1—S(O)2—, or is absent, and
M2 is selected from the group consisting of:

each E is independently selected from the group consisting of: 1) —C(R1)2—, 2) —O—C(R1)2—C(R1)2—, and 3) —C(R1)2—C(R1)2—O, wherein when E is —O—C(R1)2—C(R1)2, r is 2, and wherein when E is —C(R1)2—C(R1)2—O—, s is at least 1;
each R1 is independently selected from the group consisting of: H, and C1-C6 straight or branched alkyl;
wherein —Xm—Yn— is -X-Y- and where X-Y is selected from the group consisting of Gly, ?-Ala, Val-Cit, Phe-Lys, Val-Lys, Phe-Phe-Lys, Ala-Lys, Phe-Cit, Leu-Cit, Ala-Cit, Trp-Cit, Phe-Ala, Gly-Phe-Leu-Gly (SEQ ID NO: 38), Ala-Leu-Ala-Leu (SEQ ID NO: 39), Phe-N9-tosyl-Arg, Phe-N9-Nitro-Arg, Val-Ala, and Ala-Ala-Asn;
each Z is PABC (p-aminobenzyl-carbamoyl);
p is 0-2, q is 0-10, r is 0-2, and s is 0-2, where q+r+s=2 or more; and
D is a cytotoxic agent.

US Pat. No. 10,967,067

SCAVENGER RECEPTOR UPTAKE FOR FABRY DISEASE ENZYME REPLACEMENT THERAPY

RESEARCH FOUNDATION OF TH...

1. An engineered non-imunogenic lysosomal enzyme comprising: a lysosomal enzyme having at least one cis-aconitic anhydride coupled to at least one surface lysine residue of the lysosomal enzyme.

US Pat. No. 10,967,060

SYNERGISTIC COMBINATION OF IMMUNOLOGIC INHIBITORS FOR THE TREATMENT OF CANCER

The University of Chicago...

1. A method of treating cancer in a subject in need thereof, comprising administering to the subject an effective amount of an inhibitor of indoleamine-2,3-dioxygenase (IDO) and an inhibitor of the PD-L1/PD-1 pathway selected from the group consisting of BMS-936559, MPDL3280A, BMS-936558, MK-3475, CT-011, and MEDI47361; wherein the inhibitor of IDO is the compound:

US Pat. No. 10,967,042

PEPTIDOMIMETIC MACROCYCLES

AILERON THERAPEUTICS, INC...

1. A pharmaceutical composition comprising, in a unit dosage form:(a) a first therapeutic agent being an inhibitor of an interaction between p53 and MDM2 and/or an interaction between p53 and MDMX; and
(b) a second therapeutic agent being a chemotherapeutic agent,
wherein the first therapeutic agent is a peptidomimetic macrocycle of a Formula:

wherein:
each of Xaa3, Xaa5, Xaa6, Xaa7, Xaa8, Xaa9, and Xaa10 is independently an amino acid, wherein at least three of Xaa3, Xaa5, Xaa6, Xaa7, Xaa8, Xaa9, and Xaa10 are the same amino acids as the amino acid at the corresponding position of the sequence Phe3-X4-His5-Tyr6-Trp7-Ala8-Gln9-Leu10-X11-Ser12 (SEQ ID NO: 8) or Phe3-X4-Glu5-Tyr6-Trp7-Ala8-Gln9-Leu10/Cba10-X11-Ala12(SEQ ID NO: 9), wherein each X4 and X11 is independently an amino acid:
each D is independently an amino acid;
each E is independently an amino acid selected from the group consisting of Ala (alanine), D-Ala (D-alanine), Aib (?-aminoisobutyric acid), Sar (N-methyl glycine), and Ser (serine);
R1 and R2 are independently —H, alkyl, alkenyl, alkynyl, arylalkyl, cycloalkyl, cycloalkylalkyl, heteroalkyl, or heterocycloalkyl, unsubstituted or substituted with halo-, or forms a macrocycle-forming linker L? connected to the alpha position of one of said D or E amino acids:
each L and L? is independently a macrocycle-forming linker;
each R6 is independently —H, alkyl, alkenyl, alkenyl, arylalkyl, cycloalkylalkyl, heterocycloalkyl, a fluorescent moiety, a radioisotope or a therapeutic agent;
R7 is —H, alkyl, alkenyl, alkynyl, arylalkyl, cycloalkyl, heteroalkyl, cycloalkylalkyl, heterocycloalkyl, aryl, or heteroaryl, optionally substituted with R5, or part of a cyclic structure with a D residue;
R8 is —H, alkyl, alkenyl, alkynyl, arylalkyl, cycloalkyl, heteroalkyl, cycloalkylalkyl, heterocycloalkyl, aryl, or heteroaryl, optionally substituted with R5, or part of a cyclic structure with an E residue;
each R5 is independently halogen, alkyl, —OR6, —N(R6)2, —SR6, —SOR6, SO2R6, —CO2R6, a fluorescent moiety, a radioisotope or a therapeutic agent;
v is an integer from 1-10; and
w is an integer from 3-10.

US Pat. No. 10,967,041

COMBINATION THERAPY FOR ISCHEMIA

NoNO Inc., Toronto (CA)

1. A method of treating a damaging effect of ischemia on the central nervous system, comprisingadministering a PSD-95 inhibitor to a subject having or at risk of ischemia, and performing reperfusion therapy on the subject, wherein the PSD-95 inhibitor and reperfusion therapy synergistically treat a damaging effect of the ischemia on the central nervous system of the subject, wherein the subject is a gyrencephalic primate and wherein the PSD-95 inhibitor is administered before reperfusion therapy is performed.

US Pat. No. 10,967,015

METHOD OF TREATMENT USING ONCOLYTIC VIRUSES

New York University, New...

1. A method for treating a subject suffering from a tumor comprising administering to a subject in need of such treatment a therapeutically effective amount of a vaccinia virus (VacV) decapping deficient mutant virus.

US Pat. No. 10,967,013

LACTIC ACID BACTERIUM FOR PROPHYLAXIS OR TREATMENT OF A STRESS-INDUCED DISORDER AND A COMPOSITION CONTAINING THE SAME

National Yang-Ming Univer...

3. A method for treating a psychiatric disorder in a subject in need thereof, comprising: administering an effective amount of a composition comprising an active agent consisting of Lactobacillus plantarum subsp. plantarum PS128 to the subject, wherein the psychiatric disorder is selected from the group consisting of anxiety and depression.

US Pat. No. 10,967,003

FUNCTIONAL SEGREGATED TELODENDRIMERS AND NANOCARRIERS AND METHODS OF MAKING AND USING SAME

THE RESEARCH FOUNDATION F...

1. A compound of formula,
wherein PEG is optionally present, is a polyethylene glycol moiety, and has a molecular weight of 44 Da to 100 kDa;
X is a branched monomer unit;
each L1 is independently optional and is a linker group;
each L2 is a linker group;
each L3 is independently optional and is a linker group;
each L4 is independently optional and is a linker group,
wherein the linker groups is selected from the group consisting of a polyethylene glycol moiety, a polyserine moiety, an enzyme cleavable moiety, a disulfide bond moiety, an acid labile moiety, a polyglycine moiety, a poly(serine-glycine) moiety, an aliphatic amino acid moiety, a 6-amino hexanoic acid moiety, a 5-amino pentanoic acid moiety, a 4-amino butanoic acid moiety, and a beta-alanine moiety;
F is a functional reactive moiety that is a moiety of R1;
R1 is independently at each occurrence in the compound selected from the group consisting of a catechol, a boronic acid, a carboxylic acid, an acylhydrazine, a hydroxyl, an amine, a thiol, and a ketone for labile bond formation, wherein one or more drug(s) are optionally conjugated to one or more R1 groups; or a positively charged moiety;
each R2 independently at each occurrence in the compound is selected from the group consisting of a hydrophobic group, a hydrophilic group, an amphiphilic group, a reversible photocrosslinking group, and a drug;
and subscript m is an integer from 0 to 32.

US Pat. No. 10,966,999

3?3? CYCLIC DINUCLEOTIDES WITH PHOSPHONATE BOND ACTIVATING THE STING ADAPTOR PROTEIN

INSTITUTE OF ORGANIC CHEM...

1. A compound of formula (J):
or pharmaceutically acceptable salt thereof, wherein
L1 is —C(R6R7)—O— and L2 is —C(R13R14)—O—,
L1 is —C(R6R7)—O— and L2 is —O—C(R13R14)—,
L1 is —O—C(R6R7)— and L2 is —C(R13R14)—O—,
L1 is —C(R6R7)—K1—C(R6R7)— and L2 is —O—C(R13R14)—,
L1 is —O—C(R6R7)— and L2 is —C(R13R14)—K1—C(R13R14)—,
Y1 and Y2 are each independently —O—, —S—, or —CH2—;
X1 and X3 are each independently OH, SH, OR15, SR15, or N(R15)2;
X2 and X4 are each independently O or S;
R1, R5, R8 and R12 are each independently H, CN, N3, F, Cl, Br, I, COOR15, CON(R15)2, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, OR15, SR15, or N(R15)2;
R2, R3, R4, R9, R10 and R11 are each independently H, OH, F, Cl, Br, I, CN, N3, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, OR15, SR15, or N(R15)2;
R6, R7, R13 and R14 are each independently H, CN, N3, F, Cl, Br, I, COOR15, CON(R15)2, OR15, SR15, N(R15)2, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C7 cycloalkyl, C2-C10 heterocycloalkyl, C6-C10 aryl, or C2-C10 heteroaryl;
each R15 is independently H, —C(?Z)R16, —C(?Z)OR16, —C(?Z)SR16, —C(?Z)N(R16)2, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C7 cycloalkyl, C2-C10 heterocycloalkyl, C6-C10 aryl, or C2-C10 heteroaryl;
each R16 is independently H, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C7 cycloalkyl, C2-C10 heterocycloalkyl, C6-C10 aryl, or C2-C10 heteroaryl;
each Z is independently O, S, or NR15;
K1 is a variable that represents —O—, —S—, —S(O)—, —S(O)2—, —NH—, or —NR15—;
Base1 and Base1 are each independently:

wherein
A, A1, A2, A3 and A4 are each independently H, OH, SH, F, Cl, Br, I, NH2, OR15, SR15, NHR15, N(R15)2, or R16; and
wherein the C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C2-C10 heterocycloalkyl, C6-C10 aryl, or C2-C10 heteroaryl independently in each instance is optionally substituted with 1, 2, or 3 —OH; —SH; —NH2; ?O; ?NH; ?S; halogen; —N3; C6-C10 aryl
optionally substituted with 1, 2, or 3 —OH, —CN,
—O(C?O)ORB, —O(C?O)RB, or —COORB, unsubstituted C1-C6 alkyl; unsubstituted C1-C6 alkoxy; unsubstituted C1-C6 alkylthio; unsubstituted C1-C6 alkylamino;
unsubstituted C1-C6 dialkylamino; —CN; —O(C?O)ORB —O(C?O)RB; or —COORB; wherein RB is H or unsubstituted C1-C6 alkyl.

US Pat. No. 10,966,996

GLECHOMA LONGITUBE EXTRACT, PREPARATION METHOD FOR SAME, AND USE THEREOF IN SUGAR REDUCTION, WEIGHT LOSS, AND LIPID REDUCTION

SHANGHAI INSTITUTE OF MAT...

1. A composition comprising an extract of Glechoma longituba (Nakai) Kupr. comprising:Compound I, luteolin-7-O-[?-glucuronosyl(1?2)?-glucuronic acid]
andCompound II, apigenin-7-O-[?-glucuronosyl(1?2)?-glucuronic acid]
and the weight of both Compound I and Compound II accounts for 1%-75%, of the total weight of the extract, wherein said composition is in form of tablets, hard capsules, soft capsules, enteric capsules, microcapsules, or emulsions.

US Pat. No. 10,966,994

THROMBOXANE RECEPTOR ANTAGONISTS

ATXA THERAPEUTICS LIMITED...

1. A compound represented by formula (I):wherein:R1 is selected from the group consisting of a difluoromethoxy group, a trifluoromethoxy group, a difluoromethyl group, a primary amide group, a secondary amide group, a tertiary amide group, and a nitrile group; and
R2 is selected from the group consisting of an alkyl group of 6 or fewer carbons and a halogenated alkyl group of 6 or fewer carbons, wherein R2 is not tert-butyl, or a pharmaceutically acceptable salt thereof.

US Pat. No. 10,966,987

THERAPEUTIC COMPOUNDS AND USES THEREOF

Kala Pharmaceuticals, Inc...

7. A composition, comprising the compound of claim 1.

US Pat. No. 10,966,986

COMPOUNDS, COMPOSITIONS AND METHODS FOR CANCER PATIENT STRATIFICATION AND CANCER TREATMENT

BAYER PHARMA AKTIENGESELL...

1. A method of killing or reducing survival of a cancer cell selected as responsive to a phosphodiesterase 3A (PDE3A) modulator, the method comprising contacting the cell with a PDE3A modulator selected from compounds having the structure:
wherein the cell was selected as responsive when the cell has an increased level of a PDE3A and Schlafen 12 (SLFN12) polypeptide or polynucleotide, relative to a reference, thereby reducing the survival of the cancer cell.

US Pat. No. 10,966,984

TRANSIENT PROTECTION OF NORMAL CELLS DURING CHEMOTHERAPY

G1 Therapeutics, Inc., R...

1. A method of treating a human with cancer comprising:administering to the human an effective amount of a selective CDK4/6 inhibitor of structure:

or a pharmaceutically acceptable salt thereof; and,
administering to the human a chemotherapeutic agent;wherein the selective CDK4/6 inhibitor is administered to the human about 24 hours or less prior to administration of the chemotherapeutic agent.

US Pat. No. 10,966,977

COMBINATION OF ANTI-CD20 ANTIBODY, P13 KINASE-DELTA SELECTIVE INHIBITOR, AND BTK INHIBITOR TO TREAT B-CELL PROLIFERATIVE DISORDERS

TG Therapeutics, Inc., N...

1. A method of treating chronic lymphocytic leukemia (CLL), marginal zone lymphoma (MZL), small lymphocytic lymphoma (SLL) or mantle cell lymphoma (MCL) in a subject which comprises(a) administering to the subject a combination of agents, for a time and in therapeutically effective amounts to treat said CLL, MZL, SLL or MCL, said combination of agents comprising:
(i) at least one PI3K-delta selective inhibitor represented by Formula A, a stereoisomer thereof, a pharmaceutically acceptable salt, or solvate, thereof:

selected from
(RS)-2-(1-(4-amino-3-(3-fluoro-4-isopropoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl)-6-fluoro-3-(3-fluorophenyl)-4H-chromen-4-one; or
(S)-2-(1-(4-amino-3-(3-fluoro-4-isopropoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl)-6-fluoro-3-(3-fluorophenyI)-4H-chromen-4-one;
(ii) at least one anti-CD20 antibody or an antigen-binding fragment thereof,
wherein said anti-CD20 antibody is ublituximab or an anti-CD20 antibody that binds to the same epitope as ublituximab; and
(iii) at least one inhibitor of Bruton's tyrosine kinase (BTK) wherein said, wherein the BTK inhibitor is ibrutinib; and
(b) reducing said subject's baseline disease burden by at least 50% by the first efficacy assessment.

US Pat. No. 10,966,975

SMART BROADCAST DEVICE

Advanced New Technologies...

1. A smart broadcast device, comprising:a device body having a first surface and a lower surface joined along a common edge at an acute angle, the first surface comprising a payment graphic code;
a transceiver operable to maintain a persistent network connection, wherein the persistent network connection comprises a persistent wireless network connection, a persistent wired network connection, or both a persistent wireless connection and persistent wired connection with a payment service provider;
a processor operable to
query a binding status between the smart broadcast device and a user account registered with the payment service provider,
receive, from the transceiver, an external trigger signal sent by the payment service provider through the persistent network connection, and
generate a control signal for broadcasting a payment result audio; and
a speaker operable to output the payment result audio upon receiving the control signal from the processor.

US Pat. No. 10,966,973

COMPOSITIONS FOR TREATING OR PREVENTING VASOMOTOR SYMPTOMS

Mitsubishi Tanabe Pharmac...

1. A method for treating or preventing one or more vasomotor symptoms in a subject in need thereof, comprising:administering to the subject an effective amount of a Transient Receptor Potential Melastatin 8 (TRPM8) antagonist, wherein the TRPM8 antagonist is chosen from compounds represented by the following formula (I):
wherein:Ring A is bicyclic aromatic heterocycle comprised of (a) pyridine condensed with benzene; or (b) pyridine condensed with 5 to 6-membered monocyclic aromatic heterocycle containing carbon atoms and 1 to 4 heteroatoms chosen from oxygen atom, sulfur atom and nitrogen atom, and Ring A binds to a sulfonylamino moiety on a carbon atom adjacent to a nitrogen atom of pyridine ring constituting Ring A,
Ring B is chosen from (a) monocyclic or bicyclic aromatic hydrocarbon with 6 to 11 carbons as a ring atom; (b) monocyclic or bicyclic alicyclic hydrocarbon with 3 to 12 carbons as a ring atom; (c) 5 to 11-membered monocyclic or bicyclic aromatic heterocycle containing carbon atoms and 1 to 4 heteroatoms chosen from oxygen atom, sulfur atom and nitrogen atom; and (d) 4 to 12-membered monocyclic or bicyclic non-aromatic heterocycle containing carbon atoms and 1 to 4 heteroatoms chosen from oxygen atom, sulfur atom and nitrogen atom,
Ring C is chosen from (a) benzene; and (b) 5 to 6-membered monocyclic aromatic heterocycle containing carbon atoms and 1 to 4 heteroatoms chosen from oxygen atom, sulfur atom and nitrogen atom,
R1 is chosen from (a) hydrogen; (b) C1-C6 alkyl which may be optionally substituted by 1 to 7 groups chosen from C3-C7 cycloalkyl, C1-C6 alkoxy, halogen, oxo and hydroxy; (c) C3-C7 cycloalkyl which may be optionally substituted by 1 to 7 groups chosen from C1-C6 alkyl, C1-C6 alkoxy and halogen; (d) C1-C6 alkoxy which may be optionally substituted by 1 to 7 groups chosen from C3-C7 cycloalkyl, C1-C6 alkoxy, halogen and hydroxy; (e) phenyl which may be optionally substituted by 1 to 3 groups chosen from C1-C6 alkyl, C1-C6 halogenoalkyl, C3-C7 cycloalkyl, C3-C7 halogenocycloalkyl, C1-C6 alkoxy, C1-C6 halogenoalkoxy and halogen; (f) halogen; and (g) nitrile,
R2a, R2b, R2c and R2d are each independently chosen from (a)hydrogen; (b) C1-C6 alkyl which may be optionally substituted by 1 to 7 groups chosen from C1-C6 alkoxy, C3-C7 cycloalkyl, halogen, oxo and hydroxy; (c) C3-C7 cycloalkyl which may be optionally substituted by 1 to 7 groups chosen from C1-C6 alkyl, C1-C6 alkoxy and halogen; (d) C1-C6 alkoxy which may be optionally substituted by 1 to 7 groups chosen from C1-C6 alkoxy, C3-C7 cycloalkyl and halogen; (e) phenyl which may be optionally substituted by 1 to 3 groups chosen from C1-C6 alkyl, C1-C6 halogenoalkyl, C3-C7 cycloalkyl, C3-C7 halogenocycloalkyl, C1-C6 alkoxy, C1-C6 halogenoalkoxy and halogen; (f) 5 to 6-membered monocyclic aromatic heterocyclic group which may be optionally substituted by 1 to 3 groups chosen from C1-C6 alkyl, C1-C6 halogenoalkyl, C3-C7 cycloalkyl, C3-C7 halogenocycloalkyl, C1-C6 alkoxy, C1-C6 halogenoalkoxy and halogen; (g) 4 to 7-membered monocyclic non-aromatic heterocyclic group which may be optionally substituted by 1 to 3 groups chosen from C1-C6 alkyl, C1-C6 halogenoalkyl, C3-C7 cycloalkyl, C3-C7 halogenocycloalkyl, C1-C6 alkoxy, C1-C6 halogenoalkoxy and halogen; (h) halogen; and (i) nitrile,
R3a, R3b, R3c and R3d are each independently chosen from (a) hydrogen; (b) C1-C6 alkyl which may be optionally substituted by 1 to 7 groups chosen from C3-C7 cycloalkyl, C3-C7 halogenocycloalkyl (in which the cycloalkyl and halogenocycloalkyl may be each independently optionally substituted by 1 to 3 groups chosen from C1-C6 alkyl and C1-C6halogenoalkyl), C1-C6 alkoxy, C1-C6 halogenoalkoxy, phenyl, 5 to 6-membered monocyclic aromatic heterocyclic group, 4 to 7-membered monocyclic non-aromatic heterocyclic group (in which the phenyl, aromatic heterocyclic group and non-aromatic heterocyclic group may be each independently optionally substituted by 1 to 3 groups chosen from C1-C6 alkyl, C1-C6 halogenoalkyl, C3-C7 cycloalkyl, C3-C7 halogenocycloalkyl, C1-C6 alkoxy, C1-C6 halogenoalkoxy and halogen), halogen, oxo and hydroxy; (c) C3-C7 cycloalkyl which may be optionally substituted by 1 to 7 groups chosen from C1-C6 alkyl, C1-C6 halogenoalkyl, C1-C6 alkoxy, C1-C6 halogenoalkoxy, halogen and hydroxy; (d) C1-C6 alkoxy which may be optionally substituted by 1 to 7 groups chosen from C3-C7 cycloalkyl, C3-C7 halogenocycloalkyl (in which the cycloalkyl and halogenocycloalkyl may be each independently optionally substituted by 1 to 3 groups chosen from C1-C6 alkyl and C1-C6 halogenoalkyl), C1-C6 alkoxy, C1-C6 halogenoalkoxy, phenyl, 5 to 6-membered monocyclic aromatic heterocyclic group, 4 to 7-membered monocyclic non-aromatic heterocyclic group (in which the phenyl, aromatic heterocyclic group and non-aromatic heterocyclic group may be each independently optionally substituted by 1 to 3 groups chosen from C1-C6 alkyl, C1-C6 halogenoalkyl, C3-C7 cycloalkyl, C3-C7 halogenocycloalkyl, C1-C6 alkoxy, C1-C6 halogenoalkoxy and halogen), halogen and hydroxy; (e) C3-C7 cycloalkoxy which may be optionally substituted by 1 to 7 groups chosen from C1-C6 alkyl, C1-C6 halogenoalkyl, C1-C6 alkoxy, C1-C6 halogenoalkoxy, halogen and hydroxy; (f) phenyl which may be optionally substituted by 1 to 3 groups chosen from C1-C6 alkyl, C1-C6 halogenoalkyl, C3-C7 cycloalkyl, C3-C7 halogenocycloalkyl, C1-C6 alkoxy, C1-C6 halogenoalkoxy and halogen; (g) 5 to 6-membered monocyclic aromatic heterocyclic group which may be optionally substituted by 1 to 3 groups chosen from C1-C6 alkyl, C1-C6 halogenoalkyl, C3-C7 cycloalkyl, C3-C7 halogenocycloalkyl, C1-C6 alkoxy, C1-C6 halogenoalkoxy and halogen; (h) 4 to 7-membered monocyclic non-aromatic heterocyclic group which may be optionally substituted by 1 to 3 groups chosen from C1-C6 alkyl, C1-C6 halogenoalkyl, C3-C7 cycloalkyl, C3-C7 halogenocycloalkyl, C1-C6 alkoxy, C1-C6 halogenoalkoxy and halogen; (i) phenoxy which may be optionally substituted by 1 to 3 groups chosen from C1-C6 alkyl, C1-C6 halogenoalkyl, C3-C7 cycloalkyl, C3-C7 halogenocycloalkyl, C1-C6 alkoxy, C1-C6 halogenoalkoxy and halogen; (j) halogen; and (k) hydroxy, or
two substituent groups chosen from R3a, R3b, R3c and R3d to combine with each other to form oxo,
R5 and R6 are each independently chosen from (a) hydrogen; (b) C1-C6 alkyl; (c) C1-C6 halogenoalkyl; (d) C3-C7 cycloalkyl; and (e) C3-C7 halogenocycloalkyl, or R5 and R6 combine each other at their terminals together with the adjacent carbon atom to form 3 to 7-membered monocyclic alicyclic hydrocarbon,
n is 0, 1 or 2;
X is chosen from (a) carboxy; (b) C1-C6 alkoxycarbonyl; (c) hydroxy-C1-C6 alkyl; (d) aminocarbonyl wherein a nitrogen atom may be optionally substituted by one group chosen from C1-C6 alkyl, C1-C6 alkoxy and nitrile; and (e) C2-C7 alkanoyl which may be optionally substituted by 1 to 3 halogens;
or a pharmaceutically acceptable salt thereof;
wherein the subject is a human subject.

US Pat. No. 10,966,970

FUSED TRICYCLIC COMPOUNDS AND USES THEREOF IN MEDICINE

SUNSHINE LAKE PHARMA CO.,...

1. A compound having Formula (I) or a stereoisomer, a tautomer, an N-oxide, a solvate, a pharmaceutically acceptable salt or a prodrug thereof, wherein,
X is N or —CR6a—;
Y is a single bond, —CH2— or —C(?O)—;
Q is a single bond, —O— or —N(R9)—;
R1 is H, deuterium, F, Cl, Br, I, OH, —COOH, 5- to 6-membered heterocyclyl, 5- to 6-membered heteroaryl, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, R2—S(?O)2—, R12—(CReRf)n— or RaRbN—, wherein each of the 5- to 6-membered heterocyclyl, 5- to 6-membered heteroaryl, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl and C3-7 cycloalkyl is independently unsubstituted or substituted with 1, 2, 3 or 4 Rv;
R9 is H, deuterium, C1-6 alkyl or C1-6 haloalkyl; or, R9 and R1, together with the nitrogen atom to which they are attached, form a 3- to 12-membered heterocyclyl, wherein each of the C1-6 alkyl, C1-6 haloalkyl and 3- to 12-membered heterocyclyl is independently unsubstituted or substituted with 1, 2, 3 or 4 substituents selected from —COOH, ?O, tetrazolyl or C1-6 alkyl-O—C(?O)—;
each of R4 and R5 is independently H, deuterium, C1-6 alkyl, C1-6 alkylamino, C1-6 alkoxy, C2-6 alkynyl, C2-6 alkenyl, C3-7 cycloalkyl or 3- to 12-membered heterocyclyl, wherein each of the C1-6 alkyl, C1-6 alkylamino, C1-6 alkoxy, C2-6 alkynyl, C2-6 alkenyl, C3-7 cycloalkyl and 3- to 12-membered heterocyclyl is independently unsubstituted or substituted with 1, 2, 3 or 4 R1;
R6 is H, deuterium, C1-6 alkyl, C2-6 alkenyl, C3-7 cycloalkyl, 3- to 12-membered heterocyclyl, C6-10 aryl, 5- to 10-membered heteroaryl or Ret-C(?O)—O—(CReRf)q—, wherein each of the C1-6 alkyl, C2-6 alkenyl, C3-7 cycloalkyl, 3- to 12-membered heterocyclyl, C6-10 aryl and 5- to 10-membered heteroaryl is independently unsubstituted or substituted with 1, 2, 3 or 4 Rz;
R6a is H, deuterium, F, Cl, Br, CN, OH, C1-6 alkyl, C2-6 alkenyl, C3-7 cycloalkyl, 3- to 12-membered heterocyclyl, C6-10 aryl, 5- to 10-membered heteroaryl or R17—C(?O)—O—(CReRf)q—, wherein each of the C1-6 alkyl, C2-6 alkenyl, C3-7 cycloalkyl, 3- to 12-membered heterocyclyl, C6-10 aryl and 5- to 10-membered heteroaryl is independently unsubstituted or substituted with 1, 2, 3 or 4 Rz;
R2 is pyrrolidinyl, pyrazolidinyl, imidazolidinyl, tetrahydrofuranyl, tetrahydrothiophenyl, tetrahydropyranyl, tetrahydrothiapyranyl, piperidyl, morpholinyl, thiomorpholinyl, piperazinyl, furyl, pyrrolyl, pyridyl, pyrazolyl, imidazolyl, triazolyl, tetrazolyl, oxazolyl, isoxazolyl, oxadiazolyl, 1,3,5-triazinyl, thiazolyl, thienyl, pyrazinyl, pyridazinyl, pyrimidinyl, phenyl, or naphthyl, wherein each of the pyrrolidinyl, pyrazolidinyl, imidazolidinyl, tetrahydrofuranyl, tetrahydrothiophenyl, tetrahydropyranyl, tetrahydrothiapyranyl, piperidyl, morpholinyl, thiomorpholinyl, piperazinyl, pyrrolyl, pyridyl, pyrazolyl, imidazolyl, triazolyl, tetrazolyl, oxazolyl, isoxazolyl, oxadiazolyl, 1,3,5-triazinyl, thiazolyl, thienyl, pyrazinyl, pyridazinyl, pyrimidinyl, phenyl and naphthyl is independently unsubstituted or substituted with 1, 2, 3 or 4 Rw;
each of R3, R7 and R8 is independently H, deuterium, F, Cl, Br, hydroxy, cyano, C1-12 alkyl, C3-7 cycloalkyl, 3- to 12-membered heterocyclyl, C6-10 aryl, 5- to 10-membered heteroaryl, R13—(CReRf)m—, R13—(CReRf)m—O—, R13—C(?O)—(CReRf)m—, R13—C(?O)—N(Rg)—(CReRf)m—, R13—O—C(?O)—(CReRf)m—, R13—O—C(?O)—N(Rg)—(CReRf)m—, Re—C(?O)—(CReRf)m—O—C(?O)—,
R14—S(?O)2—(CReRf)m—, R14—S(?O)2—N(Rg)—(CReRf)m—, R14—S(?O)2—N(Rg)—C(?O)—, RaRbN—, RcC(?O)—, RaRbNC(?O)—, RdOC(?O)— or R10O—, wherein each of the C1-12 alkyl, C3-7 cycloalkyl, 3- to 12-membered heterocyclyl, C6-10 aryl and 5- to 10-membered heteroaryl is independently unsubstituted or substituted with 1, 2, 3 or 4 Rw;R10 is H, deuterium, C1-12 alkyl, C2-12 alkynyl, C3-7 cycloalkyl, 3- to 12-membered heterocyclyl, C6-10 aryl, 5- to 10-membered heteroaryl, R15—(CReRf)g—, R15—O—(CReRf)g—, R15—C(?O)—(CReRf)g—, R15O—C(?O)—(CReRf)g—, R15—O—C(?O)—N(Rg)—(CReRf)g—, R16—S(?O)2—(CReRf)g— or R16—S(?O)2—N(Rg)—(CReRf)g—, wherein each of the C1-12 alkyl, C2-12 alkynyl, C3-7 cycloalkyl, 3- to 12-membered heterocyclyl, C6-10 aryl and 5- to 10-membered heteroaryl is independently unsubstituted or substituted with 1, 2, 3 or 4 Rx;
each R12 and R17 is independently C3-7 cycloalkyl, C6-10 aryl, C1-6 alkoxy, amino or C1-6 alkylamino, wherein each of the C3-7 cycloalkyl, C6-10 aryl, C1-6 alkoxy, amino and C1-6 alkylamino is independently unsubstituted or substituted with 1, 2, 3 or 4 Rj;
each R13, R14, R15 and R16 is independently C1-12 alkyl, C1-12 alkoxy, C3-7 cycloalkyl, 5- to 10-membered heteroaryl, 3- to 12-membered heterocyclyl or C6-10 aryl, wherein each of the C1-12 alkyl, C1-12 alkoxy, C3-7 cycloalkyl, 5- to 10-membered heteroaryl, 3- to 12-membered heterocyclyl and C6-10 aryl is independently unsubstituted or substituted with 1, 2, 3 or 4 Rh;
R13a is methyl, C2-12 alkyl, C1-12 alkoxy, C3-7 cycloalkyl, 5- to 10-membered heteroaryl, 3- to 12-membered heterocyclyl or C6-10 aryl, wherein each of the methyl and C6-10 aryl is independently substituted with 1, 2, 3 or 4 Rh, and wherein C2-12 alkyl, C1-12 alkoxy, C3-7 cycloalkyl, 5- to 10-membered heteroaryl and 3- to 12-membered heterocyclyl is independently unsubstituted or substituted with 1, 2, 3 or 4 Rh;
each Ra, Rb, Rc, Rd, Re, Rf, Rg, Rk, Ri, and Rm is independently H, deuterium, OH, C1-6 haloalkyl, C1-6 alkyl, C1-6 alkoxy, C2-6 alkenyl, C2-6 alkynyl, C3-6 cycloalkyl, C6-10 aryl, 3- to 12-membered heterocyclyl or 5- to 10-membered heteroaryl, wherein each of the C1-6 haloalkyl, C1-6 alkyl, C1-6 alkoxy, C2-6 alkenyl, C2-6 alkynyl, C3-6 cycloalkyl, C6-10 aryl, 3- to 12-membered heterocyclyl and 5- to 10-membered heteroaryl is independently unsubstituted or substituted with 1, 2, 3 or 4 substituents independently selected from F, Cl, Br, CN, OH, amino, C1-6 alkyl, C1-6 haloalkyl, C1-6 alkoxy or C1-6 alkylamino;
or, Ra and Rb, together with the nitrogen atom to which they are attached, form a 3- to 8-membered heterocyclyl or 5- to 8-membered heteroaryl, wherein each of the 3- to 8-membered heterocyclyl and 5- to 8-membered heteroaryl is independently unsubstituted or substituted with 1, 2, 3 or 4 substituents independently selected from F, Cl, Br, CN, OH, amino, C1-6 alkyl, C1-6 haloalkyl, C1-6 alkoxy or C1-6 alkylamino;
each Rv, Rw, Rx, Ry, Rz, Rj and Rh is independently F, Cl, Br, CN, OH, —COOH, amino, C1-12 alkyl, C1-12 haloalkyl, C1-12 alkoxy, C1-12 haloalkoxy, C1-12 alkylthio, C1-12 alkylamino, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, 3- to 12-membered heterocyclyl, C6-10 aryl or 5- to 10-membered heteroaryl, wherein each of the amino, C1-12 alkyl, C1-12 haloalkyl, C1-12 alkoxy, C1-12 haloalkoxy, C1-12 alkylthio, C1-12 alkylamino, C2-6 alkenyl, C2-6 alkynyl, C3-7 cycloalkyl, 3- to 12-membered heterocyclyl, C6-10 aryl and 5- to 10-membered heteroaryl is independently unsubstituted or substituted with 1, 2, 3 or 4 substituents independently selected from F, Cl, Br, CN, OH, ?O, —COOH, amino, C1-6 alkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 alkylthio, C1-6 haloalkoxy, C1-12 alkylamino, C2-6 alkenyl, C2-6 alkynyl, C6-10 aryl, C3-6 cycloalkyl, 5- to 6-membered heteroaryl, 5- to 6-membered heterocyclyl, C1-6 alkoxy-C1-6-alkyl or C1-6 alkylamino-C1-6-alkyl;
each n and q is independently 0, 1, 2, 3, 4, 5 or 6;
each t and f is independently 1, 2, 3, 4, 5 or 6; and
each m and g is independently 0, 1, 2, 3, 4, 5, 6, 7, 8, 9 or 10.

US Pat. No. 10,966,969

THERAPEUTIC AGENT FOR LIVER DISEASES

APTABIO THERAPEUTICS INC....

1. A method for alleviating or treating a non-alcoholic fatty liver disease (NAFLD), the method comprising administering at least one compound selected from a pyrazole-based compound represented by the following Formula 1 and a pharmaceutically acceptable salt thereof:
wherein R is a C1-C10 linear or branched alkyl group.

US Pat. No. 10,966,968

CO-ADMINISTRATION OF ROSIGLITAZONE AND EICOSAPENTAENOIC ACID OR A DERIVATIVE THEREOF

Amarin Pharmaceuticals Ir...

1. A method of reducing triglycerides without increasing LDL-C in a subject having a fasting baseline triglyceride level of at least 500 mg/dl, the method comprising administering to the subject about 8 mg of rosiglitazone and about 4 g of a pharmaceutical composition comprising at least about 97%, by weight, ethyl eicosapentaenoate per day.

US Pat. No. 10,966,967

ARYL DIHYDROPYRIDINONES AND PIPERIDINONE MGAT2 INHIBITORS

Bristol-Myers Squibb Comp...

1. A compound of Formula (II):
or a stereoisomer, a tautomer, or a pharmaceutically acceptable salt thereof, wherein:
R1 is independently a 5- to 6-membered heteroaryl substituted with 0-1 Rb and 0-2 Rg, wherein said heteroaryl is selected from: pyridyl, oxazolyl, thiazolyl and

R2 is independently selected from the group consisting of: C1-4 alkyl and C1-4 haloalkyl;
R3 is independently selected from the group consisting of: H and F;
R4 is independently selected from the group consisting of: H and F;
R6 is independently Rc or —(CH2)n—(X)t—(CH2)mRc;
X is independently selected from the group consisting of: O, S, NH, CONH, and NHCO;
R11 and R15 are independently selected from the group consisting of: H, C1-4 alkyl and halo;
R12 and R14 are independently selected from the group consisting of: H, halo, C1-4 alkyl and C1-4 alkoxy;
R13 is independently selected from the group consisting of: H, halo, C1-4 alkyl substituted with 0-1 C1-4 alkoxy, C1-4 alkoxy, C1-4 haloalkyl, C1-4 haloalkoxy, —(CH2)m—C3-4 cycloalkyl, CN, N(C1-4 alkyl)2, NHCO2(C1-4 alkyl), NHSO2(C1-4 alkyl), pyrazolyl, and morpholinyl;
alternatively, R12 and R13, together with the carbon atoms to which they are attached, combine to form a 5- to 6-membered carbocyclic ring or a 5- to 6-membered heterocyclic ring comprising: carbon atoms and 1-3 heteroatoms selected from N, NRe, O, and S;
Rb is, at each occurrence, independently selected from the group consisting of: halo, OH, C1-8 alkyl, C1-8 alkoxy, C1-8 haloalkyl, C1-10 haloalkoxy, —O(CH2)sO(C1-6 alkyl), N(C1-4 alkyl)2, —CONH(CH2)6-20H, —(CH2)m(C3-6 cycloalkyl), —(CH2)m(C4-6 cycloalkenyl), —O(CH2)m(C3-6 cycloalkyl), 4-C1-4 alkoxy-Ph, —O(CH2)mPh, morpholinyl, pyridyl, 2-C1-4 alkoxy-pyridin-5-yl, pyrimidinyl, pyrazinyl, and —O-pyrimidinyl;
Rc is, at each occurrence, independently selected from the group consisting of: C3-6 cycloalkyl substituted with 0-2 Rd, C3-6 cycloalkenyl substituted with 0-2 Rd, —(CH2)m-(phenyl substituted with 0-3 Rd), and a 5- to 6-membered heterocycle comprising: carbon atoms and 1-4 heteroatoms selected from N, NRe, O, and S; wherein said heterocycle is substituted with 0-2 Rd;
Rd is, at each occurrence, independently selected from the group consisting of: halo, OH, CN, NO2, C1-4 alkyl, C1-4 alkoxy, C1-4 haloalkyl, C1-4 haloalkoxy, tetrazolyl, OBn and phenyl substituted with 0-2 Rh;
Re is, at each occurrence, independently selected from the group consisting of: H, C1-8 alkyl, C1-8 haloalkyl, benzyl optionally substituted with C1-4 alkoxy, CO(C1-4 alkyl) and COBn;
Rg and Rh are, at each occurrence, independently selected from the group consisting of: halo, C1-4 alkyl, C1-4 alkoxy, C1-4 haloalkyl, and C1-4 haloalkoxy;
n, at each occurrence, is independently 0 or 1;
m, at each occurrence, is independently 0, 1, 2 or 3;
s, at each occurrence, is independently 1, 2, or 3; and
t, at each occurrence, is independently 0 or 1.

US Pat. No. 10,966,963

TETRAHYDRO-PYRIDO[3,4-B]INDOLE ESTROGEN RECEPTOR MODULATORS AND USES THEREOF

Genentech, Inc., South S...

1. A compound selected from Formula I:
or a stereoisomer, tautomer, or pharmaceutically acceptable salt thereof, wherein:
Y2 is —(CH2)—;
Ra is independently H, C1-C6 alkyl, C2-C8 alkenyl, propargyl, C3-C6 cycloalkyl, or C3-C6 heterocyclyl, optionally substituted with one or more groups independently selected from F, Cl, Br, I, CN, OH, OCH3, or SO2CH3;
Rb is independently H, C1-C6 alkyl, C2-C8 alkenyl, propargyl, —(C1-C6 alkyldiyl)—(C3-C6 cycloalkyl), C3-C6 cycloalkyl, and C3-C6 heterocyclyl, optionally substituted with one or more groups independently selected from F, Cl, Br, I, CN, —CH2F, —CHF2, —CF3, —CH2CF3, —CH2CHF2, —CH2CH2F, OH, OCH3, or SO2CH3;
RC is independently H, C1-C6 alkyl, allyl, propargyl, optionally substituted with one or more groups independently selected from F, Cl, Br, I, CN, OH, OCH3, or SO2CH3;
Z1 a bond;
Cy is C6-C20 aryldiyl or a 5 to 6-membered heteroaryldiyl;
Z2 is O—(C1-C6 alkyldiyl);
R1 and R2 are H;
R3 is H, and R4 is —CH3;
R5 is C1-C9 alkyl optionally substituted with one or more of halogen, CN, ORa, N(Ra)2, C1-C9 alkyl, C3-C9 cycloalkyl, C3-C9 heterocycle, C6-C9 aryl, C6-C9 heteroaryl, C(O)Rb, C(O)NRa, SO2Ra, or SO2NRa;
R6 is F, Cl, Br, I, —CN, —CH3, —CH2CH3, —CH(CH3)2, —CH2CH(CH3)2, —CH2OH, —CH2OCH3, —CH2CH2OH, —C(CH3)2OH, —CH(OH)CH(CH3)2, —C(CH3)2CH2OH, —CH2CH2SO2CH3, —CH2OP(O)(OH)2, —CH2F, —CHF2, —CH2NH2, —CH2NHSO2CH3, —CH2NHCH3, —CH2N(CH3)2, —CF3, —CH2CF3, —CH2CHF2, —CH2CH2F, —CH(CH3)CN, —C(CH3)2CN, —CH2CN, —CO2H, —COCH3, —CO2CH3, —CO2C(CH3)3, —COCH(OH)CH3, —CONH2, —CONHCH3, —CONHCH2CH3, —CONHCH(CH3)2, —CON(CH3)2, —C(CH3)2CONH2, —NH2, —NHCH3, —N(CH3)2, —NHCOCH3, —N(CH3)COCH3, —NHS(O)2CH3, —N(CH3)C(CH3)2CONH2, —N(CH3)CH2CH2S(O)2CH3, —NO2, ?O, —OH, —OCH3, —OCH2CH3, —OCH2CH2OCH3, —OCH2CH2OH, —OCH2CH2N(CH3)2, —OP(O)(OH)2, —S(O)2N(CH3)2, —SCH3, —S(O)2CH3, —S(O)3H, cyclopropyl, cyclopropylamide, cyclobutyl, oxetanyl, azetidinyl, 1-methylazetidin-3-yl)oxy, N-methyl-N-oxetan-3-ylamino, azetidin-1-ylmethyl, benzyloxyphenyl, pyrrolidin-1-yl, pyrrolidin-1-yl-methanone, piperazin-1-yl, morpholinomethyl, morpholino-methanone, or morpholino; and
m is 0, 1, 2, 3, or 4;
where alkyldiyl, fluoroalkyldiyl, aryldiyl, carbocyclyldiyl, heterocyclyldiyl, and heteroaryldiyl are optionally substituted with one or more groups independently selected from the group consisting of F, Cl, Br, I, —CN, —CH3, —CH2CH3, —CH(CH3)2, —CH2CH(CH3)2, —CH2OH, —CH2OCH3, —CH2CH2OH, —C(CH3)2OH, —CH(OH)CH(CH3)2, —C(CH3)2CH2OH, —CH2CH2SO2CH3, —CH2OP(O)(OH)2, —CH2F, —CHF2, —CF3, —CH2CF3, —CH2CHF2, —CH2CH2F, —CH(CH3)CN, —C(CH3)2CN, —CH2CN, —CH2NH2, —CH2NHSO2CH3, —CH2NHCH3, —CH2N(CH3)2, —CO2H, —COCH3, —CO2CH3, —CO2C(CH3)3, —COCH(OH)CH3, —CONH2, —CONHCH3, —CON(CH3)2, —C(CH3)2CONH2, —NH2, —NHCH3, —N(CH3)2, —NHCOCH3, —N(CH3)COCH3, —NHS(O)2CH3, —N(CH3)C(CH3)2CONH2, —N(CH3)CH2CH2S(O)2CH3, —NO2, ?O, —OH, —OCH3, —OCH2CH3, —OCH2CH2OCH3, —OCH2CH2OH, —OCH2CH2N(CH3)2, —OP(O)(OH)2, —S(O)2N(CH3)2, —SCH3, —S(O)2CH3, —S(O)3H, cyclopropyl, cyclopropylamide, cyclobutyl, oxetanyl, azetidinyl, 1-methylazetidin-3-yl)oxy, N-methyl-N-oxetan-3-ylamino, azetidin-1-ylmethyl, benzyloxyphenyl, pyrrolidin-1-yl, pyrrolidin-1-yl-methanone, piperazin-1-yl, morpholinomethyl, morpholino-methanone, and morpholino.

US Pat. No. 10,966,961

PYRAZOLE DERIVATIVES AS BROMODOMAIN INHIBITORS

GLAXOSMITHKLINE INTELLECT...

1. A compound of formula (I)or a pharmaceutically acceptable salt thereofwherein:R1 is —C1-3alkyl or cyclopropyl;
R2 is —C0-3alkyl-cycloalkyl, wherein the cycloalkyl group is optionally substituted with one, two, or three R5 groups which may be the same or different;
or R2 is —C0-4alkyl-heterocyclyl or —(CH2)pO-heterocyclyl, wherein each heterocyclyl is optionally substituted by one or two R9 groups which may be the same or different; or
R2 is H, —CH3, —C2-6alkyl optionally substituted by one, two, three, four or five fluoro, —C2-6alkylOR6, —C2-6alkylNR10aR11a, —(CH2)mSO2C1-3alkyl, —(CH2)mSO2NR10R11, (CH2)mC(O)NR10R11, —(CH2)mCN, —(CH2)mCO2R6, —(CH2)mNHCO2C1-4alkyl, —(CH2)mNHC(O)C1-4alkyl, or —(CH2)nheteroaryl, wherein the heteroaryl is optionally substituted by one or two R7 groups which may be the same or different;
R3 is H, —C1-4alkyl, cyclopropyl, —CH2F, —C1-3alkylOR6, or —C1-3alkylCN;
R4 is phenyl or a heteroaryl group, wherein each are optionally substituted by one, two, or three R7 groups which may be the same or different;
each R5 is independently halo, —C0-6alkyl-R8, —OCH2phenyl, —CN, or —SO2C1-3alkyl;
R6 is H or —C1-4alkyl;
each R7 is independently oxo, halo, —C1-4alkyl optionally substituted by one, two or three fluoro, —C0-3alkylOR6, —OC2-3alkylOR6, —C0-3alkylNR10R11, —C0-3alkyl-CONR10R11, —SO2—C1-3alkyl,—SO2NR10R11, or —SO2phenyl optionally substituted by —C1-4alkyl;
R8 is H, —OR6, —NR10R11 heteroaryl;
each R9 is independently halo, —C1-4alkyl, cyclopropyl, cyclobutyl, —CH2CF3, —CH2CHF2, —CH2CH2F, —OCH2CH2OR6, —C0-3alkylOR6, —C0-3alkylNR10R11, —NHCH2CH2OR6, —NHCO2C1-4alkyl, oxo, —C(O)R6, —C(O)OR6, or —C(O)NR10R11,
R10 and R11 are each independently selected from H and —C1-3alkyl; or R10 and R11 may join together with the nitrogen to which they are attached, to form a 4 to 7-membered heterocyclyl optionally substituted by one or two substituents independently selected from —C1-3alkyl optionally substituted with one, two, or three fluorine atoms, —C2-4alkylOH, —OH, and F;
R10a and R11a are each independently selected from H and —C1-3alkyl;m is an integer selected from 2, 3, or 4;n is an integer selected from 0, 1, 2, 3, or 4; andp is an integer selected from 2, 3, or 4.

US Pat. No. 10,966,959

USE OF A ROTIFER-DERIVED COMPOUND AND ITS ANALOGS FOR PREVENTING SCHISTOSOMIASIS

Wisconsin Alumni Research...

1. A method of preventing schistosomiasis, comprising administering to a subject at risk of schistosomiasis infection, an effective amount of a compound of Formula I,
or stereoisomer, tautomer, and/or a pharmaceutically acceptable salt thereof, wherein
R1 is H, OH, or C1-C3 alkoxy;
R2 is H or C1-C3 alkyl; and
R3 is H or C1-C3 alkyl.

US Pat. No. 10,966,958

COMPOSITION COMPRISING A DIINDOLYLMETHANE AND A RETINOID TO TREAT A SKIN CONDITION

SKINTECH LIFE SCIENCE LIM...

1. A composition formulated for oral or topical administration, comprising:(a) a first component comprising a substituted or unsubstituted 3,3? diindolylmethane compound and/or a substituted or unsubstituted 2,2? diindolylmethane compound having a structure of:

wherein each R is independently selected from selected from hydrogen and C1-C6 hydrocarbon substituents; and
(b) a second component comprising a substituted or unsubstituted retinoid compound selected from a substituted or unsubstituted retinal, a substituted or unsubstituted retinol, a substituted or unsubstituted tretinoin, a substituted or unsubstituted isoretinoin, and a substituted or unsubstitutedalitretinoin.

US Pat. No. 10,966,955

OCULAR DRUG DELIVERY SYSTEM AND USES THEREOF

Chang Gung University, T...

1. An ocular drug delivery system, comprising:a positively charged chitosan-modified hydrogel which is obtained by a process including subjecting a hydrogel to a click chemistry reaction with a chitosan;
a secretory phospholipase A2 (sPLA2) hydrolysable liposome encapsulating an anti-inflammatory drug and having a negative surface charge;
a first thiolated hyaluronic acid (HA-SH) nanoparticle encapsulating a wound-healing drug and having a negative surface charge; and
a second HA-SH nanoparticle encapsulating a transforming growth factor-? (TGF-?) inhibitor and having a negative surface charge, the second HA-SH nanoparticle having a crosslinking index higher than that of the first HA-SH nanoparticle;
wherein the sPLA2 hydrolysable liposome, the first HA-SH nanoparticle, and the second HA-SH nanoparticle are attached to the positively charged chitosan-modified hydrogel by electrostatic attraction.

US Pat. No. 10,966,954

ELECTROPHILICALLY ENHANCED PHENOLIC COMPOUNDS FOR TREATING INFLAMMATORY RELATED DISEASES AND DISORDERS

GLOBAL BIOLIFE INC., Bet...

1. A compound having a formula selected from the group consisting of:

US Pat. No. 10,966,951

COMPOSITIONS AND METHODS FOR LOWERING TRIGLYCERIDES IN A SUBJECT HAVING REDUCED KIDNEY FUNCTION

Amarin Pharmaceuticals Ir...

1. A method of preventing progression of stage 3 chronic kidney disease in a subject having an estimated glomerular filtration rate (eGFR) of less than 60 mL/min/1.73 m2 for at least 3 months, the method comprising administering to the subject about 4 g ethyl eicosapentaenoate (E-EPA) per day for a period of at least 12 weeks.

US Pat. No. 10,966,950

USE OF AN RXR AGONIST IN TREATING HER2+ CANCERS

Io Therapeutics, Inc., H...

1. A method of treating a patient with Her2+breast cancer comprising administering a RXR agonist of Formula I,
wherein R is H, or lower alkyl of 1 to 6 carbons; or a pharmaceutically-acceptable salt thereof, to the patient,
wherein the patient is receiving, or is scheduled to receive a Her2-targeted therapeutic antibody.

US Pat. No. 10,966,948

COMPOSITIONS AND METHODS FOR TREATING THE EYE

1. A method for treating the symptoms associated with dry eye, the method comprising the step of topically administering to a patient a composition comprising:i) a safe and effective amount of a compound and/or extract having retinol-like properties for treating dry eye and/or benefits for use in treating dry eye selected from one or more of:
(a) one or more extracts from plants of the genera Acronychia, Licaria, and/or Trigonella;
(b) one or more extracts of species of the genus Actinomyces; and
(c) one or more compounds of Formula (I):

wherein—
the dotted lines represent a single or double bond;
R1 represents an H, a carbon chain that is linear, cyclic, or branched, saturated or unsaturated, comprising from 1 to 20 carbon atoms;
R2 represents a carbon chain that is linear, cyclic, or branched, saturated or unsaturated, comprising from 1 to 20 carbon atoms; and
A represents a carbon chain that is linear, cyclic, or branched, saturated or unsaturated, comprising from 1 to 20 carbon atoms;
ii) one or more demulcent or soothing agents; and
iii) optionally, an ophthalmologically acceptable carrier.

US Pat. No. 10,966,943

METHODS AND COMPOSITIONS FOR TREATMENT OF ASTHMA OR PARKINSON'S DISEASE

INNOPHARMASCREEN INC., I...

1. A method of treating asthma in a subject in need thereof, the method comprising administering to the subject a pharmaceutical composition comprising a compound represented by Formula 1 or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable excipient:

US Pat. No. 10,966,936

SYSTEMS COMPRISING A COMPOSITE BACKING AND METHODS FOR LONG TERM TRANSDERMAL ADMINISTRATION

Corium, Inc., Grand Rapi...

1. A transdermal patch, comprising:a composite backing layer comprised of (i) a first layer comprised of a polymer fabric or a polymer film having a stretchability of at least 5% in at least one direction; (ii) a second layer comprised of one or more adhesive polymers; and (iii) a third layer comprised of one or more polymer films; wherein the first and second layers are in contact and the second and third layers are in contact, and wherein the third layer comprises cuts formed at least partially through the layer; and
an adhesive matrix drug layer comprising one or more drugs laminated to the third layer.

US Pat. No. 10,966,934

PROCESS FOR PRODUCING COATED PARTICLES

DSM IP ASSETS B.V., Heer...

1. A process for the production of coated particles having a core and a coating layer surrounding the core, wherein the process comprises the steps of:(a) forming cores of the coated particles by introducing into a top spraying device 40 wt-% 95 wt-%, based on the total weight of the coated particles, of a core material which consists of:
(i) at least 20 wt-%, based on the total weight of the solid particles, of at least one fat soluble vitamin,
(ii) at least one emulsifier, and
(iii) at least one non-reducing sugar,
(b) introducing into the top spraying device 5 wt-%-60 wt-%, based on the total weight of the coated particles, of a coating system which comprises at least one wax and/or at least one fat selected from the group consisting of carnauba wax, candelilla wax, sugarcane wax and (fully) hydrogenated palm oil, and
(c) operating the top spraying device to spray a molten form of the coating system onto the cores to thereby form the coated particles each comprised of a core formed of the core material and a deformable coating layer having an irregular thickness and a plurality of vacuoles formed of the coating system surrounding the core, wherein
the top spraying device is operated throughout steps (a)-(c) at an atomizing air pressure of 1 bar and an atomizing air temperature of 100 to 120° C.

US Pat. No. 10,966,932

ENCASED TAMPER RESISTANT CONTROLLED RELEASE DOSAGE FORMS

Purdue Pharma L.P., Stam...

1. A solid controlled release dosage form comprising:a core comprising a first portion of oxycodone or a pharmaceutically acceptable salt thereof dispersed in a first matrix material; and
a shell encasing the core and comprising a second portion of the oxycodone or pharmaceutically acceptable salt thereof dispersed in a second matrix material;
wherein the amount of oxycodone or pharmaceutically acceptable salt thereof released from the dosage form is proportional within 20% to elapsed time from 8 to 24 hours, as measured by an in-vitro dissolution in a USP Apparatus 1 (basket) at 100 rpm in 900 ml simulated gastric fluid without enzymes (SGF) at 37° C.

US Pat. No. 10,966,930

ANTICANCER COMPOSITIONS

Aragon Pharmaceuticals, I...

1. A combination of a pharmaceutical formulation comprising a pharmaceutically acceptable carrier and a solid dispersion comprising ARN-509, a poly(meth)acrylate copolymer and hydroxypropyl methylcellulose acetate succinate; and another anticancer agent.

US Pat. No. 10,966,928

ORAL DOSAGE FORM

Universiteit Gent, Ghent...

1. A method of preparing a pellet, the method comprising:mixing one or more active agents to form a mixture comprising from 1% to 15% by weight partially hydrolyzed polyvinyl alcohol (PVOH) with a degree of hydrolysis between 70% and 95%, and from 0.5% to 35% by weight of microcrystalline cellulose (MCC), wherein the one or more active agents are included in the mixing at at least 40% by weight;
wetting the mixture to form a wet mixture;
extruding the wet mixture to obtain an extrudate;
spheronizing the extrudate to obtain a plurality of pellets; and
drying the plurality of pellets.

US Pat. No. 10,966,925

EPINEPHRINE SPRAY FORMULATIONS

HIKMA PHARMACEUTICALS USA...

1. An epinephrine spray formulation comprising:about 2.96% w/w epinephrine base;
about 32.93% w/w hydrochloric acid with a normality of about 0.5N;
about 0.05% w/w edetate disodium dihydrate;
about 0.15% w/w sodium bisulfite;
about 0.01% w/w benzalkonium chloride;
about 0.6% w/w sodium chloride; and
about 63.30% w/w water,wherein the formulation provides a pharmacokinetic parameter selected from the group consisting of a Cmax from about 256 to about 418 picograms per milliliter, a Tmax from about 0.13 to about 0.376 hours, an AUClast of about 231 h*pg/mL, an AUCinf from about 273 to about 377 h*pg/mL and a combination thereof.

US Pat. No. 10,966,916

PERSONAL CARE COMPOSITIONS

The Procter and Gamble Co...

1. A personal care composition containing a microcapsule consisting of:a structured cleansing phase comprising about 2% to about 50% of an anionic surfactant;
a benefit phase comprising at least one triglyceride oil selected from the group consisting of olive oil, sunflower oil, soybean oil, peanut oil, rapeseed oil, almond oil, palm oil, coconut oil, palm kernel oil, and mixtures thereof at a level that does not impair the formation of the clusters of microcapsules upon dilution of said composition with water; from about 0.01% to about 2% of a first and second cationic deposition polymer; a plurality of anionic microcapsules wherein the Zeta potential of said microcapsules is less than negative 0.5 millivolts and the weight ratio of said microcapsules to cationic polymers is from about 5:1 to about 12:1;
a carrier and wherein the personal care composition optionally contains a dye, preservative, perfume and mixtures thereof.

US Pat. No. 10,966,914

SKIN MIMICKING EMULSION

COUNTER BRANDS, LLC, San...

1. A composition comprising polyosides and minerals derived from aloe vera present in a combined total amount of about 0.01 to 1.00% w/w, inositol polyphosphate or phytic acid derived from green rice present in about 0.10 to 1.50% w/w, polysaccharides selected from the group consisting of xanthan gum, pullulan, Sclerotium gum, Caesalpinia gum, Acacia senegal gum, xylitol and sodium hyaluronate present in a combined total amount of about 0.05-2.00% w/w, triglycerides derived from palm present in about 0.50-15.00% w/w, polyols derived from corn present in about 0.20-10.00% w/w, alpha or beta hydroxy acids derived from Gaultheria present in about 0.05-0.490% w/w, phospholipids derived from Glycine max present in about 0.20-8.00% w/w, phytosterols derived from shea butter present in about 0.04-10.00% w/w, vitamins derived from Glycine max present in about 0.01-2.00% w/w, fatty alcohols derived from candelilla wax and coconut present in about 0.50-8.00% w/w, lipids present in about 0.10-10.00% w/w, amino acids derived from beet roots present in about 0.05-3.00% w/w, and water present in about 42.0-84.8% w/w; wherein the composition forms a lamellar structure which is an emulsion made of layers.

US Pat. No. 10,966,912

MEDICAMENT

Symrise AG, Holzminden (...

1. A non-therapeutical method for treating or ameliorating human skin hyperpigmentation induced by the radiation of visible light with a wavelength in the range of 400 to 700 nm, comprising the step of:applying a preparation comprising a pigmentation-changing effective amount of at least one compound of formula (I), or a cosmetically acceptable salt of a compound of formula (I), or a mixture containing two or more of these compounds or the salts thereof

provided that R1 denotes H or CH3 and R2 denotes H or COOH, said preparation excluding dioic acid, larixol, cyclohexyl carbamate, lipoic acid, sclareolide, and a combination of a resorcinol derivative and bisabolol,
to human skin areas having said hyperpigmentation induced by the radiation of visible light with a wavelength in the range of 400 to 700 nm.

US Pat. No. 10,966,909

RESIN COMPOSITES FOR USE IN DENTAL PREVENTIVE AND RESTORATIVE APPLICATIONS

ADA Foundation, Chicago,...

1. A polymerizable dental resin composition, comprising:a reaction product of a resin monomer having one or more functionalized vinylbenzyl ether groups n of the formula
covalently bonded to one or more R functional components;wherein n is 1 or greater than 1,
wherein the X components are one of a hydrogen atom and one or more functional moieties to control the rate of polymerization, the functional moieties being one or more compounds or elements selected from a first group consisting of —CH3, —C2H5, —OCH3, —CF3, —F, —Cl, —Br, —CN, —C2H5, —C3H7, —C4H9, —OC2H5, —OC3H7, and —OC4H9,
wherein the R functional components are selected from a second group consisting of N-(2-hydroxypropyl)-N-(p-styryl)glycine, N-(2-hydroxypropyl)-N-(phenyl)glycine, N-(2-hydroxypropyl)-N-(p-tolyl)glycine (NTG-VBGE), N-(2-hydroxypropyl)-N-(3,5-dimethylphenyl)glycine, and (vinylbenzyl)glycine,
wherein each of the R functional components may be acidic, anionic, or a salt of one or more members selected from a third group consisting of sodium, magnesium, calcium, and strontium, and
wherein an ether link connects each of the functionalized vinylbenzyl groups with each of the R functional groups.

US Pat. No. 10,966,908

DISPENSER OF SUBSTANCE DOSES WITH DISH FOR COLLECTION THEREOF

1. A dispensing device for dispensing substances to be taken by a user, wherein the dispensing device comprises:a memory for storing an indication of a taking plan of a plurality of doses of one or more substances, the taking plan comprising an indication of a taking time of each dose;
a plurality of compartments each one for containing one of the doses,
a signaling unit for providing a taking notice of each dose in response to the corresponding taking time;
a plate having a collecting surface arranged at a central zone of the dispensing device, the dispensing device having a vertical axis located at a center of the dispensing device, wherein the vertical axis passes through the dispensing device's central zone;
a wheel housing the compartments in a peripheral zone of the plate, the compartments being closed towards the collecting surface by a side surface of the plate;
a releasing opening in the side surface of the plate facing towards the central zone for releasing the dose of each compartment placed in correspondence thereto towards the central zone, such that when a dose is released from the compartment through the releasing opening, the dose moves toward the dispensing device's vertical axis;
a motor for rotating the wheel thereby bringing the compartment of each dose in correspondence to the releasing opening in response to the corresponding taking time;
a pushbutton for controlling the releasing opening by closing the releasing opening in a rest condition and opening the releasing opening for releasing the dose corresponding to each taking notice from the corresponding compartment in response to a releasing command; and
wherein the pushbutton is arranged in the plate in correspondence to the releasing opening, the pushbutton being maintained in front of the releasing opening by elastic means for closing the releasing opening and sinking into the collecting surface in opposition to the elastic means in response to a manual pressure for opening the releasing opening.

US Pat. No. 10,966,906

METHOD FOR PRODUCING A MEDICAL PREPARATION

Fresenius Kabi Deutschlan...

1. A method for producing a medical preparation, for parenteral nutrition, comprising: transferring liquid by a peristaltic pump from a plurality of source containers into a target container, and weighing the target container at individual metering steps, wherein quantity of the liquid transferred into the target container is thus checked at the individual metering steps, in which an impeller of the peristaltic pump is at a rotation angle within a rotation region with a linear characteristic curve, liquid is removed from another source container, different than the target container, the other source container filled with universal liquid or water.

US Pat. No. 10,966,905

SYSTEMS AND METHODS FOR SAFE MEDICAMENT TRANSPORT

CORVIDA MEDICAL, INC., C...

1. A medicament container assembly, comprising:a vial defining a cavity therein, the vial includes a neck defining an open end, the vial includes a medicament disposed within the cavity thereof and a stopper inserted in the open end of the neck and sealing the medicament within the cavity; and
a vial adapter assembly connected to the neck of the vial, the vial adapter assembly including:
a transfer adapter sleeve;
a shuttle valve slidably disposed within the transfer adapter sleeve; and
a transfer adapter needle connected to the shuttle valve and fluidly connectable to a fluid container through the shuttle valve, the transfer adapter needle includes a first sharpened tip disposed at a distal end thereof, and a second sharpened tip disposed at a proximal end thereof, wherein the shuttle valve has at least a first position wherein the transfer adapter needle is disposed within the transfer adapter sleeve and is not in fluid communication with the fluid container, and at least a second position wherein the transfer adapter needle is moved to extend the second sharpened tip thereof from the transfer adapter sleeve through the seal of the vial and into the cavity of the vial to be in direct fluid communication with the cavity of the vial.

US Pat. No. 10,966,904

CONTAINER SYSTEM AND METHOD

BOEHRINGER INGELHEIM VETM...

1. A container system, comprising:at least two containers, and
a light member which is configured to provide information through the emission of light,
wherein the light member is triggerable to provide the information through the emission of light produced by chemiluminescence in response to an event related to preparing a mixture from contents of the containers,
wherein the containers, in a transporting position, are releasably connected to one another, and wherein the activation of the light member is responsive to separation of the containers from one another while the containers are closed for preparation of a fluidic connection between the containers.

US Pat. No. 10,966,903

ADAPTOR FOR COUPLING TO A MEDICAL CONTAINER

Becton Dickinson Holdings...

1. A method of using an adaptor coupled with a medical container having a collar closed by a septum, said septum having an outer surface directed towards an outside of the medical container, the method comprising:providing a tubular body substantially closed at a distal end with a transversal wall provided with a central hole and substantially closed at a proximal end by a pierceable elastomeric piece, said pierceable elastomeric piece defining a distal plug at a distal end thereof, said pierceable elastomeric piece, transversal wall, and tubular body together defining an inner cavity of said adaptor, said pierceable elastomeric piece being movable within said tubular body between a first position, in which said distal plug is seated within and forms a seal with said central hole, and a second position, in which said distal plug is displaced from said central hole;
providing an air inlet in the adaptor for allowing air from the outside to enter said inner cavity at least when said pierceable elastomeric piece moves from the first position to the second position, said air inlet comprising a filtering system for decontaminating said entering air before it reaches said inner cavity and said air inlet being in fluid communication with said central hole when said pierceable elastomeric piece is in said second position;
securing the adaptor to the medical container so that a distal surface of said transversal wall is brought in contact with the outer surface of said septum when said adaptor is secured on said medical container; and
piercing the elastomeric piece of the adaptor and the septum of the medical container with a needle of an injection device to be filled with a dose of a product contained within the medical container.

US Pat. No. 10,966,902

LUNG GAS EXCHANGE DEVICE

19. A method for treating a patient having chronic pulmonary disease, comprising:vibrating a column of air by applying vibration to a portion of an anterior neck of the patient; and
applying a lung gas exchange device to the portion of the anterior neck, wherein the lung gas exchange device comprises,
a front housing;
at least one strap configured to affix the front housing to the portion of the anterior neck;
a vibration device positioned within the front housing;
a wear plate configured to vibrate a column of air by transferring vibration from the vibration device to the portion of the anterior neck;
a power source configured to provide power to the vibration device;
a central processing unit board connected to the power source and the vibration device; and
at least one second strap having two ends attached to a strap loop of the wear plate, the at least one second strap is configured to extend under an armpit of the patient and around a back of the patient such that the two ends of the at least one second strap are attached to the strap loop,
wherein the vibration of the column of air by applying the vibration to the portion of the anterior neck includes applying the vibration using the lung gas exchange device.

US Pat. No. 10,966,901

MASSAGE SYSTEM

FUJI MEDICAL INSTRUMENTS ...

1. A massage system comprising:a massage machine that is adapted to perform a massage on a person to be treated;
a display device;
a controller for controlling the massage machine and the display device,
wherein the controller is programmed to start the massage machine according to a massage course and to display an image corresponding to the massage course on the display device, after the massage course is selected,
the image includes a moving image of a virtual practitioner performing the massage;
wherein the display device is a head worn type display device that is adapted to be worn on a head portion of the person to be treated;wherein the massage machine includes a seat portion and a backrest portion tiltably attached to the seat portion;the head worn type display device includes a head tracking function and a position tracking function;
the controller displays, on the display, a message for making the person to be treated face forward when the display is worn by the person to be treated,
after a predetermined time from the display of the message, the controller sets a current direction and a position of the display respectively as a reference direction for head tracking and a reference position for position tracking, and detects an inclination angle of the backrest portion with respect to the seat portion and stores the angle as a first inclination angle,
the controller detects the inclination angle of the backrest portion with respect to the seat portion right before the reproduction of the video is started and stores the angle as a second inclination angle, and
when the second inclination angle differs from the first inclination angle, the controller corrects, based on a difference between the second inclination angle and the first inclination angle, the reference direction and the reference position to be of values that are in accordance with the current posture of the person to be treated.

US Pat. No. 10,966,900

MASSAGE MACHINE

FAMILY INADA CO., LTD., ...

1. A massage machine comprising:a first massage mechanism that is disposed on a relatively upper side of the massage machine and a second massage mechanism that is disposed on a relatively lower side of the massage machine, as the massage mechanisms; and
control means that controls operations of the massage mechanisms;
wherein each of the massage mechanisms comprising:
a pair of left and right treatment members and a kneading shaft that supports the pair of left and right treatment members via inclined shafts at ends of the kneading shaft,
a distance between the pair of left and right treatment members of the first massage mechanism being in closest positions and a distance between the pair of left and right treatment members of the second massage mechanism being in closest positions are different,
a distance between one of the ends of the kneading shaft of the first massage mechanism and one of the pairs left and right treatment members supported by the one of the ends of the first massage mechanism and a distance between one of the ends of the kneading shaft of the second massage mechanism and one of the left and right treatment members supported by the one of the ends of the second massage mechanism are different, and
an inclination angle of one of the inclined shafts at one of the ends of the kneading shaft of the first massage mechanism and an inclination angle of one of the other inclined shafts at one of the ends of the kneading shaft of the second massage mechanism are different;
wherein the massage mechanisms are able to perform massaging operations when the treatment members operate in at least a lateral direction so as to approach each other and be separated from each other according to the rotation of the kneading shafts of the first and the second massage mechanisms;
wherein the first and second massage mechanisms are able to perform massaging operations when the first and second pairs of the treatment members operate in first and second trajectories having at least lateral and vertical directional components respectively according to rotation of the kneading shafts of the first and the second massage mechanisms;
wherein the first and second trajectories are in an arc-like or a loop-like shape; and
wherein the first massage mechanism and the second massage mechanism are set such that the lateral directional components and vertical directional components of the first and second trajectories respectively are different.

US Pat. No. 10,966,899

AIR MASSAGE DEVICE

FUJI MEDICAL INSTRUMENTS ...

1. An air massage chair device, comprising:a plurality of air bags, wherein each airbag comprises a plurality of airbag carriers overlapped and integrally connected with one another forming one internal air room communication;
an air pump for supplying air into each airbag of the plurality of air bags;
a plurality of air supply valves for switching on-off of air supply into each of the air bags;
a storage part for storing an electric input value sent to the air pump and an opening and closing timing for each of the air supply valves; and
a control part for controlling an amount of the supplied air into each of the airbags per unit time according to the electric input value, and for repeatedly opening and closing the air supply valves which correspond to the each of the airbags at the opening and closing timing stored in the storage part, and opening and closing of each of the air supply valves depends on the amount of the supplied air into each of the air bags;
wherein at a first predetermined electric input value of the air pump, the air pump is configured to provide a maximum amount of air supply into each of the airbags and at a second predetermined electric input value of the air pump, the air pump is configured to provide less amount of air supply than said maximum amount of air supply, wherein said first predetermined electric input value of the air pump is greater than said second predetermined electric input value of the air pump;
wherein at a first step of expansion, said each of the airbags are expanded to a first predetermined level with said maximum amount of air supply at a first expansion rate, and at a second step of expansion, said each of the airbags are expanded to a second predetermined level with said less amount of air supply than said maximum amount of air supply at a second expansion rate;
wherein said second expansion rate is slower than said first expansion rate;
wherein the control part enables the electric input value to be set and each of the air supply valves to be opened and closed based on a plurality of predetermined treatment courses;
wherein during treatment operations in one treatment course among the plurality of predetermined treatment courses, the control part, in a first stage, opens the air supply valve corresponding to at least one airbag of the plurality of air bags and sets the electric input value to a high electric value until the at least one air bag is expanded to a certain expanding condition, and the control part, in a second stage, changes the electric input value from the high electrical input value to a low electric input level and repeatedly opens and closes the air supply valves at the opening and closing timing stored in the storage part.

US Pat. No. 10,966,898

FIDGET SLEEVE

1. A plurality of removable sleeves, each removable sleeve comprising:an elongate hollow tube having two or more different types of manipulatives, each manipulative having a different manipulative action, molded onto or permanently attached to an outside surface of said tube wherein at least one of said manipulatives comprises a nut turned on a screw attached at an upper end portion of said tube wherein said nut is not removable from said sleeve wherein said sleeve is configured to be slipped over a writing implement wherein said sleeve is configured to have a lower portion thereof configured to be used by a user to hold said writing implement during a writing process, wherein said sleeve is configured to remain in place during use of said writing implement in said writing process, wherein said manipulatives are configured to be manipulated by said user allowing expenditure of energy by manipulation of said manipulatives, and wherein said sleeve is configured to be slipped off of said writing implement and replaced by another one of said plurality of sleeves.

US Pat. No. 10,966,897

AUTOMATED WALKER ASSEMBLY

1. A walking assistance apparatus comprising:a housing having a top wall, a bottom wall and a perimeter wall extending between and being attached to said top and bottom walls, said perimeter wall having a front side, a rear side, a first lateral side and a second lateral side;
a plurality of wheel mounts being attached to said housing and extending downwardly therefrom;
a plurality of wheels being attached to said wheel mounts such that a pair of front wheels is defined and a pair of rear wheels is defined;
a pair of handles being attached to said housing;
a plurality of drive assemblies being mounted to said housing to control said housing, said drive assemblies including:
a propulsion drive being mechanically coupled to at least one of said wheels to define a drive wheel, said propulsion drive being actuated to rotate said drive wheel in a first direction or a second direction;
a direction drive being mechanically coupled to at least one of said wheels to define a directional wheel, said direction drive being actuated to rotate a rotational axis of said directional wheel left or right;
an interface being mounted on said housing and electrically coupled to each of said drive assemblies to selectively actuate each of said drive assemblies; and
an accelerometer being mounted on said housing and being electrically coupled to said interface, said accelerometer being configured to detect a threshold acceleration event caused by a person falling while gripping said housing, said interface actuating said drive assemblies to create a counteraction event to counteract said threshold acceleration event.

US Pat. No. 10,966,896

ROLLATOR BRAKING SYSTEM

MAPLE LEAF MEDICAL SERVIC...

1. A rollator comprising:a collapsible frame comprising a right subframe and a left subframe joined by a perpendicular supporting member;
at least three wheels, wherein on each of the right subframe and the left subframe is rotatably mounted at least one of the at least three wheels;
a seat mounted to the right subframe and left subframe or to the perpendicular supporting member and configured to be accessible from a backside of the rollator;
at least one brake mounted to the collapsible frame and operable to slow rotation of one of the at least three the wheels;
an adjustable handle supported by the collapsible frame;
a bracket fixedly mounted to the adjustable handle;
a lever rotatably mounted to the bracket and disposed below the adjustable handle;
a wire connected on a first end to the lever and on a second end to the at least one brake such that the wire applies the at least one brake when the lever is rotated toward the bracket and the wire applies the at least one brake when the lever is fixed in a locked position; and
a lock movably connected to the bracket, disposed below the adjustable handle and slidably disposed through the bracket, and configured to fix the lever in the locked position when the lever is rotated toward the adjustable handle and the lock is depressed into the bracket.

US Pat. No. 10,966,895

EXOSKELETON CONTINUOUS-USE FIT EVALUATION SYSTEM AND METHOD

ROAM ROBOTICS INC., San ...

1. A method of performing a moving fit test on a wearable pneumatic exoskeleton system coupled to a user:coupling the wearable pneumatic exoskeleton system to legs of a user, the wearable pneumatic exoskeleton system comprising:
a left and right pneumatic leg actuator unit respectively associated with a left and right leg of the user, the left and right pneumatic actuator units each including:
a rotatable joint configured to be aligned with a rotational axis of a knee of the user wearing the pneumatic exoskeleton system,
an upper arm coupled to the rotatable joint and extending along a length of an upper leg portion above the knee of the user wearing the pneumatic exoskeleton system,
a lower arm coupled to the rotatable joint and extending along a length of a lower leg portion below the knee of the user wearing the pneumatic exoskeleton system, and
an inflatable bellows actuator defining a bellows cavity, the inflatable bellows actuator configured to extend along a length of the bellows actuator when pneumatically inflated by introducing pneumatic fluid into the bellows cavity and configured to actuate the upper arm and lower arm;
a pneumatic system configured to introduce pneumatic fluid to the bellows actuators of the pneumatic leg actuator units to independently actuate the bellows actuators, and
an exoskeleton computing device including:
a plurality of sensors,
a memory storing at least a moving fit test program, and
a processor configured to execute the moving fit test program to control the pneumatic system; and
executing the moving fit test program by the processor to cause pneumatic exoskeleton system to:
generate a moving fit testing position indication instructing the user to perform or prepare to perform one or more movements for the moving fit test;
determining that the user has assumed an initial moving fit test dynamic stance phase;
actuating the left and right pneumatic leg actuator units while the user is performing the one or more movements for the moving fit test;
determining a first configuration of the upper arm and lower arms of the left and right pneumatic leg actuator units generated in response to the actuating the left and right pneumatic leg actuator unit while the user is performing the one or more movements for the moving fit test, the determining of the first configuration based at least in part on data obtained from one or more of the plurality of sensors;
determining a change from the first configuration of the upper arm and lower arm of the left and right pneumatic leg actuator units while the user is performing the one or more movements for the moving fit test, the determining based at least in part on data obtained from one or more of the plurality of sensors;
determining that the change from the first configuration corresponds to an improper fit of at least one of the left and right pneumatic leg actuator units coupled to the legs of the user; and
generating an improper fit indication that indicates improper fit of at least one of the left and right pneumatic leg actuator units coupled to the legs of the user.

US Pat. No. 10,966,894

EXOSKELETON LEGS TO REDUCE FATIGUE DURING REPETITIVE AND PROLONGED SQUATTING

The Regents of the Univer...

1. An apparatus configured to be coupled to a wearer, the apparatus comprising:a first exoskeleton leg comprising:
a thigh link;
a shank link;
a knee joint coupled to the thigh link and the shank link, and configured to allow flexion and extension motion between the thigh link and the shank link;
a force generator comprising a first end and a second end, wherein the first end is coupled to the shank link, and wherein the second end is coupled to the thigh link;
a constraining mechanism coupled to the thigh link, wherein the constraining mechanism is configured to have at least two operation modes, a constrained mode and an unconstrained mode; and
a first signal processor configured to move the constraining mechanism between its at least two operation modes,
wherein, when in the constrained mode, the constraining mechanism is configured to limit the second end of the force generator to a rotational motion relative to the thigh link, and is configured to provide support to the wearer when the knee of the wearer is flexing, and
wherein, when in the unconstrained mode, the constraining mechanism is configured to allow additional motion of the second end of the force generator relative to the thigh link in addition to the rotational motion, and is configured to provide no support to the wearer when the knee of the wearer is flexing.

US Pat. No. 10,966,893

EXOSKELETON APPARATUS FOR LIMB REHABILITATION

HIWIN TECHNOLOGIES CORP.,...

1. An exoskeleton apparatus for limb rehabilitation comprising:a base unit including a base, and a first actuator disposed on said base;
a support unit driven by said first actuator to rotate about a vertical first axis relative to said base, and including a support that is pivotally connected to said base, and a positioning seat that is connected to said support, that is disposed above said base, and that is provided with a second actuator and a third actuator;
an upper arm unit including
a linking axle,
a main arm that has a connecting end rotatably connected to said positioning seat and driven by said second actuator to rotate about a horizontal second axis which is perpendicular to the first axis, and a linking end opposite to said connecting end and connected to said linking axle, and
a linkage mechanism that is disposed on a side of said main arm, that is connected between said positioning seat and said linking end of said main arm, and that is driven by said third actuator to rotate said linking axle relative to said linking end of said main arm about a horizontal third axis that is parallel to the second axis; and
a lower arm unit driven by said linkage mechanism to rotate relative to said upper arm unit, and including a lower arm set that is fixedly and co-rotatably coupled to said linking axle, a hand-receiving seat that is rotatably connected to said lower arm set and that is adapted for receiving a hand, and a lower arm receiving seat that is connected to said hand-receiving seat, that is disposed on a side of said lower arm set, and that is adapted for receiving a lower arm,
said lower arm set being provided with a fourth actuator for rotating said hand-receiving seat about a horizontal fourth axis which is perpendicular to the first and second axes;
wherein said base unit includes an elevating member that is operable for lifting and lowering said first actuator, said support unit, and said upper and lower arm units relative to said base; and
wherein said linkage mechanism includes a connecting plate connected to said positioning seat and rotatable about the second axis, a first link having one end that is pivotally connected to said connecting plate, a second link having one end that is pivotally connected to the other end of said first link, a third link having one end that is pivotally connected to the other end of said second link and that is disposed between said second link and said linking end of said main arm, and the other end that is co-rotatably coupled to said linking axle, and a fourth link having one end that is pivotally connected to said first link and said second link, and the other end that is pivotally connected to said linking end of said main arm, said linking axle extending along the third axis.

US Pat. No. 10,966,892

SURGICAL FRAME FACILITATING ARTICULATABLE SUPPORT FOR A PATIENT DURING SURGERY

WARSAW ORTHOPEDIC, INC., ...

1. A positioning frame for supporting a patient, the positioning frame comprising:a first support structure at a first positioning-frame end of the positioning frame, and a second support structure at an opposite second positioning-frame end of the positioning frame;
a single main beam having a first main-beam end, a second main-beam end, and a length extending between the first and second main-beam ends, the first support structure supporting the single main beam at the first main-beam end, the second support structure supporting the single main beam at the second main-beam end, the first support structure and the second support structure spacing the single main beam from the ground, the single main beam defining an axis of rotation relative to the first support structure and the second support structure, the single main beam being rotatable about the axis of rotation between at least a first rotational position and a second rotational position, the axis of rotation substantially corresponding to a cranial-caudal axis of the patient when the patient is supported on the positioning frame,
the single main beam including a first portion at the first main-beam end that extends transversely to the axis of rotation thereof, a second portion at the second main-beam end that extends transversely to the axis of rotation thereof, and a third portion extending between the first portion and the second portion of the single main beam, the first portion of the single main beam having a first end and an opposite second end, the first portion of the single main beam being attached adjacent the first end thereof relative to the first support structure, the second portion of the single main beam having a third end and an opposite fourth end, the second portion of the single main beam being attached adjacent the third end thereof relative to the second support structure, the third portion of the single main beam being offset from the axis of rotation by the first portion and the second portion of the single main beam, the third portion of the single main beam including a fifth end, an opposite sixth end, a first side, and an opposite second side, and the third portion singularly connecting the first portion and the second portion to one another to facilitate support of the patient by at least the third portion and between the first portion and the second portion, the second end of the first portion of the single main beam being connected to the fifth end of the third portion of the single main beam via a first connection, and the fourth end of the second portion of the single main beam being connected to the sixth end of the third portion of the single main beam via a second connection;
a torso-lift support solely attached to the third portion of the single main beam, the torso-lift support including a chest support being configured to support a chest of the patient, the torso-lift support being pivotally connected to the single main beam, the torso-lift support being configured to pivot the chest support between at least a first position and a second position to move a torso of the patient between an unlifted position and a lifted position; and
a pelvic-tilt support attached at least relative to the first side of the third portion of the single main beam, the pelvic-tilt support including a thigh cradle and a lower leg cradle, the thigh cradle being configured to support thighs of the patient, and the lower leg cradle being configured to support the lower legs of the patient, the thigh cradle and the lower leg cradle being pivotal with respect to one another to facilitate adjustment of hips of the patient;
wherein at least the torso-lift support and the pelvic-tilt support support the patient in a patient-receiving area between the first portion of the single main beam, the second portion of the single main beam, and the first side of the third portion of the single main beam, the patient-receiving area being uninterrupted by the first portion, the second portion, and the third portion of the single main beam; and
wherein a first plane extends along the first side of the third portion of the single main beam, and the cranial-caudal axis, the torso, the hips, the thighs, and the lower legs of the patient are positioned on only one side of the first plane when the patient is supported by the positioning frame, a second plane extends transverse to the axis of rotation and between the torso-lift support and the pelvic-lift support, and a third plane being parallel to the axis of rotation and transverse to the second plane, the third plane being adjacent to the first side of the third portion lying within the second plane, the third plane being on one side of the cranial-caudal axis of the patient, no portion of the positioning frame being used to support the patient that is rotatable about the axis of rotation and located within the second plane being on the other side of the cranial-caudal axis of the patient opposite the one side.

US Pat. No. 10,966,891

MEDICAL WORKSTATION MOUNTING APPARATUS

1. A medical workstation mounting apparatus for mounting accessories to a medical workstation, the apparatus comprising an elongate body and defining front and rear faces, the medical workstation mounting apparatus being configured for attachment to a shelf of a medical workstation along said rear face, the apparatus having a length, a depth and a thickness, wherein the thickness is the distance between the front and rear faces, said thickness defining a distance said medical workstation mounting apparatus extends from the shelf when installed on said shelf, a plurality of accessory receivers extending from the body, each accessory receiver comprising a pair of arms defining therebetween a channel configured to receive a hook of an accessory, said bods further including a protruding region extending forward from the rear face and defining a generally rectangular channel between the body and said shelf when the apparatus is installed on said shelf, wherein the apparatus has a maximum thickness which is less than its maximum depth.

US Pat. No. 10,966,890

INFANT WARMERS HAVING INTEGRAL BACKUP WARMING BLANKET

General Electric Company,...

1. A warming device configured to warm an infant, the warming device comprising:a base configured to support the infant;
an overhead portion that includes an enclosure;
an arm coupled to the base and to the overhead portion, wherein the arm supports the overhead portion above the base;a heating element configured to generate a heat to warm the infant, wherein the overhead portion includes the heating element, and wherein a portion of the heat is dissipated into the overhead portion as a waste heat; anda warming blanket having a stored state and a deployed state, wherein in the stored state the warming blanket is at least partially inside the overhead portion, wherein in the deployed state the warming blanket is outside the overhead portion, wherein the warming blanket is configured to store the waste heat when the warming blanket is in the stored state, and wherein the warming blanket is configured to warm the infant when in the deployed state.

US Pat. No. 10,966,889

SUPPORT APPARATUSES COMPRISING COOLING ELEMENTS

HILL-ROM SERVICES, INC., ...

1. A support apparatus configured to be placed on a mattress and configured to support a person, the support apparatus comprising:a top surface including a first predetermined area and a second predetermined area separated from the first predetermined area; and
an enclosed area comprising:
a first conduit and a second conduit located inside the enclosed area of the support apparatus, the first conduit connected to a first air pocket located proximate to the first predetermined area, the second conduit connected to a second air pocket located proximate to the second predetermined area; and
an air supply positioned inside the enclosed area of the support apparatus and directly connected to the first conduit and the second conduit, the air supply configured to provide air to the first and second conduits simultaneously for delivering to the first and second predetermined areas, wherein one end of each of the first and second conduits and the other end of each of the first and second conduits are directly connected to the air supply, the air supply comprising:
a temperature sensor configured to measure a temperature of the air provided by the air supply;
a cooling element; and
a controller communicatively coupled to the temperature sensor and the cooling element, the controller comprising at least one processor and at least one memory storing computer readable and executable instructions that, when executed by the processor, cause the controller to:
determine whether the measured temperature of the air is higher than a predetermined temperature; and
control the cooling element to cool the air to the predetermined temperature if it is determined that the temperature of the air is higher than the predetermined temperature,
wherein an entirety of the first air pocket is at a vertically higher position inside the enclosed area than an entirety of the first conduit, and an entirety of the second air pocket is at a vertically higher position than an entirety of the second conduit.

US Pat. No. 10,966,888

TOOTH CLUTCH TRANSMISSION FOR WHEELCHAIRS

1. A human mobility device, comprising:a frame;
a seat configured to support a human;
a plurality of wheels connected to said frame;
a transmission connected to said frame and at least one of said plurality of wheels; and,
at least one lever connected to said frame and to said transmission, and further sized and configured for movement by a human in said seat;
wherein said transmission comprises:
an input drive shaft coupled to said lever and being axially movable; said input drive shaft having a first axis;
an output drive shaft coupled to said plurality of wheels; and,
a clutch mechanism having a first clutch face that remains facing a second clutch face in a direction aligned with said first axis and configured such that movement of said input drive shaft along said first axis to a first position moves the first clutch face against the second clutch face so as to operatively couple said input drive shaft to said output drive shaft, and axial movement of said input drive shaft along said first axis to a second position moves the first clutch face away from the second clutch face so as to operatively uncouple said input drive shaft from said output drive shaft.

US Pat. No. 10,966,887

REMOVABLE CARTRIDGES FOR A SPINE BOARD

RX 1186, LLC, Fairfield,...

1. A removable cartridge system comprising:a spine board;
a receiving channel in the spine board;
a removable cartridge removably located in the receiving channel and comprising:
hollow elongated body having a leading end, a trailing end, a top surface and a bottom surface, wherein the leading end is configured to be inserted into the receiving channel before the trailing end; and
a button on the elongated body and positioned proximate the trailing end of the elongated body; and
at least one safety strap housed in the hollow elongated body of the removable cartridge;
wherein the removable cartridge is configured such that after the removable cartridge is inserted into the receiving channel, the button is removably inserted into an opening in the spine board that intersects with the receiving channel so as to lock the removable cartridge in the receiving channel.

US Pat. No. 10,966,886

SANITARY PRODUCT DISPOSAL CONTAINERS AND METHODS

1. A sanitary product disposal method, comprising:providing a sanitary product disposal container having a container interior and including a first container wall having a first container wall exterior surface, a second container wall having a second container wall exterior surface, a container opening formed between the first container wall and the second container wall, a first wall indentation and a second wall indentation in the first container wall and the second container wall, respectively, at the container opening and container seals on the first container wall exterior surface of the first container wall and the second container wall exterior surface of the second container wall, generally at or adjacent to the container opening, the container seals traversing a length of the container opening and a first wall gusset extending from the first container wall, a second wall gusset extending from the second container wall and a sanitary product cavity formed by and between the first wall gusset and the second wall gusset, a gusset indentation in the first wall gusset and a pair of side container walls extending between the first container wall and the second container wall, with the pair of side container walls closing the container interior along the first container wall and the second container wall and along the first wall gusset and the second wall gusset;
inserting fingers of a hand into the sanitary product disposal container;
grasping a sanitary product with the fingers through a container wall of the sanitary product disposal container;
cradling the sanitary product in the sanitary product cavity between the first wall gusset and the second wall gusset;
grasping the gusset indentation with a thumb of an opposite hand to facilitate inversion of the container;
internalizing the sanitary product into the sanitary product disposal container by inverting the sanitary product disposal container; and
sealing the sanitary product disposal container by pressing together the container seals on the respective first container wall and the second container wall to seal the interior from the exterior of the container, whereby liquids and odors are sealed in the container interior.

US Pat. No. 10,966,885

ABSORBENT ARTICLE WITH HIGH ABSORBENT MATERIAL CONTENT

1. An absorbent article comprising a front region, a back region, a crotch region disposed between the front region and the back region, and a longitudinal axis extending in a longitudinal direction of the article, the absorbent article comprising:a) a liquid permeable topsheet;
b) a liquid impermeable backsheet;
c) an absorbent core disposed between the topsheet and backsheet, the absorbent core comprising a combination of superabsorbent polymer and cellulose fibers;
d) an acquisition-distribution layer disposed between the absorbent core and the topsheet;
e) at least one channel positioned within a layer between the topsheet and the backsheet, and longitudinally-extending within a portion of the front region and the crotch region;
wherein the article has a Relative Crotch Width Reduction (RCWR) of 32-150 mm/kg, wherein the RCWR is calculated according to the formula:

wherein Wd is the dry crotch width, wherein Ww is the wet crotch width at the crotch point, wherein Mw is the wet mass of the article, wherein Md is the dry mass of the article, wherein the measurements are made as indicated according to RCWR Test, and wherein the article has a dry crotch width Wd of from about 70 mm to about 200 mm;
wherein the topsheet and the backsheet are substantially planar before the article is loaded with fluid according to the RCWR Test; and
wherein at least one of the topsheet and the backsheet become non-planar at the completion of the RCWR Test due to the presence of the at least one channel.

US Pat. No. 10,966,884

ABSORBENT CORE HAVING FUNNEL-SHAPED SWELLING CHAMBER

1. An absorbent core comprising an absorbent material enclosed in a core wrap, wherein the core wrap which comprises a liquid permeable substrate layer and the absorbent material comprises from about 87% to about 100% of superabsorbent polymer by weight of the absorbent material, the core further comprising a funnel-shaped swelling chamber disposed in between two external zones; wherein:permanent seals separate the funnel-shaped chamber from each of the two external zones;
the funnel-shaped swelling chamber consists of absorbent material immobilized by water-responsive bonds, wherein said water-responsive bonds deteriorate upon exposure to water such that the absorbent material is flowable in the wet state; and
the two external zones comprise absorbent material that is immobilized by thermoplastic adhesive, such that the absorbent material is immobilized in the wet state.

US Pat. No. 10,966,883

ABSORBENT CORE HAVING TUBE-SHAPED SWELLING CHAMBER

1. An absorbent core comprising absorbent material disposed in an absorbent material deposition area and enclosed in a core wrap, wherein the core wrap comprises a liquid permeable substrate layer and the absorbent material comprises from about 87% to about 100% of superabsorbent polymer by weight of the absorbent material, the absorbent core further comprising a tube-shaped swelling chamber, the tube-shaped swelling chamber having a length to width aspect ratio of less than or equal to about 5:1;wherein the area of the core is at least twice the area of the swelling chamber, and the core contains a water responsive immobilizing agent to immobilize the superabsorbent polymer prior to water insult; and
wherein the tube-shaped swelling chamber is a portion of the absorbent core containing superabsorbent polymer that is delimited by a plurality of continuous permanent seals that each join together a top substrate layer and a bottom substrate layer of the core wrap and prevent superabsorbent polymer from moving across the seals, wherein at least two continuous permanent seals are longitudinally-extending and void of absorbent material wherein the chamber comprises a first chamber end at a first longitudinal position and a second chamber end at a second longitudinal position, wherein the first chamber end of the tube-shaped swelling chamber is closed by joining two or more of the continuous permanent seals together at the first chamber end and the second chamber end comprises an open end such that the plurality of continuous permanent seals are not joined to one another at the second longitudinal position, and
wherein at the open end, at least one of the two or more of the continuous permanent seals each extend to a longitudinal edge of the absorbent material deposition area.

US Pat. No. 10,966,882

ABSORBENT ARTICLE AND METHOD FOR MANUFACTURING ABSORBENT ARTICLE

1. An absorbent article comprising an absorbent core sandwiched between a liquid-permeable topsheet and a liquid-impermeable backsheet, said article being arranged along a longitudinal axis and a transversal axis extending in a perpendicular direction in relation to the longitudinal axis and said article defining a front portion, a back portion and a crotch portion,wherein said absorbent core comprises an absorbent component enclosed by a core cover comprising an upper side and a lower side, and welding spots for joining said upper and lower sides,
wherein said welding spots comprise two side seams extending along two side edges in the direction of the longitudinal axis of said core,
wherein said welding spots further comprise at least one transversally oriented connecting sealing, said at least one connecting sealing joining said side seams, and
wherein a sum of an area of the welding spots is constant along the direction of the transversal axis.

US Pat. No. 10,966,881

ABSORBENT GARMENT INSERT

1. A system comprising:a. an absorbent garment having an interior surface configured with a fluid porous inner surface that is configured to face a wearer, the inner surface being opposed by an fluid impervious outer surface configured to face outward from the wearer and a fluid absorbent core disposed between at least between a portion of the inner surface and outer surface,
b. an insert capable of being fitted between a portion the wearer's body and the interior surface of the absorbent garment, the insert comprising;
i. an upper cover that is fluid porous,
ii. a lower cover opposing the upper cover,
iii. a plurality of layers of an absorbent filling material consisting essentially of super absorbent polymer (SAP) particles dispersed in a network of non-hydrophilic fibers,
iv. wherein the upper cover and lower cover are sealed about a common perimeter to contain the absorbent filling material in an interior cavity, and
c. wherein the lower cover is an apertured film comprising an array perforations, each perforation in the array having a frustoconical shape with an open apex spaced apart from an open base, the base having a larger diameter than the apex and being closer to the absorbent filling material than the open apex.

US Pat. No. 10,966,880

METHODS AND TOOLING FOR MAKING THREE-DIMENSIONAL SUBSTRATES FOR ABSORBENT ARTICLES

19. A method of making a three-dimensional, apertured substrate on an absorbent article manufacturing line, the method comprising:conveying a precursor substrate in a machine direction on the absorbent article manufacturing line;
providing a first roll having a first rotational axis;
providing a second roll having a second rotational axis, wherein the first rotational axis and the second rotational axis are positioned generally parallel to each other to form a nip between the first and second rolls;
wherein the first roll comprises:
a first radial outer surface;
a first plurality of projections extending at least partially outwardly from the first radial outer surface, wherein the first plurality of projections are configured to form apertures in the precursor substrate;
a first plurality of recesses defined in the first radial outer surface;
first distal portions of at least some of the first plurality of projections forming elongated aperturing structures, wherein the elongated aperturing structures comprise side walls; and
first distal ends of the at least some of the first plurality of projections forming a point;
wherein the first plurality of projections each have a first central longitudinal axis extending through the point;
wherein the second roll comprises:
a second radial outer surface;
a second plurality of projections extending at least partially outwardly from the second radial outer surface, wherein the second plurality of projections are configured to form three-dimensional elements in the precursor substrate, and wherein the second plurality of projections comprise second distal portions and second distal ends;
a second plurality of recesses defined in the second radial outer surface; and
wherein at least some of the second plurality of projections comprise shoulders positioned intermediate bases and the second distal ends, wherein opposite side walls of the bases are parallel to each other;
wherein the second plurality of projections have a second central longitudinal axis;
wherein the second distal portions comprise distal ends that are flat, or substantially flat;
rotating the first roll in a first direction about the first rotational axis;
rotating the second roll in a second, opposite direction about the second rotational axis;
intermeshingly engaging portions of the first plurality of projections with portions of the second plurality of recesses in the nip;
intermeshingly engaging portions of the second plurality of projections with portions of the first plurality of recesses in the nip;
conveying the precursor substrate through the nip; and
forming in the nip at least two of:
apertures in the precursor substrate using the at least some of the first plurality of projections and the at least some of the second plurality of recesses;
three-dimensional elements in the precursor substrate in areas free of the apertures using the at least some of the second plurality of projections and the at least some of the first plurality of recesses; and
compressed regions of the precursor substrate formed between portions of the side walls and portions of the shoulders.

US Pat. No. 10,966,879

DISPOSABLE DIAPER

UNICHARM CORPORATION, Eh...

1. A disposable diaper, comprising:a front waist region, a rear waist region and a crotch region located between the front and rear waist regions and includes a vertically elongated absorbent chassis extending toward the front and rear waist regions and centering on the crotch region,whereinthe absorbent chassis includes an absorbent structure and a pair of side flaps extending outward in the lateral direction from both side edges of the absorbent structure,
each of the side flaps is formed of layered sheet materials and includes
a distal edge being spaced apart in the lateral direction from the side edge of the absorbent structure and extending in the vertical direction,
a cuff branch line defined between the side edge of the absorbent structure and the respective distal edge so as to extend in the vertical direction,
a leg-opening elasticized area extending between the cuff branch line and the distal edge and a leakage-barrier cuff branched from the cuff branch line and extending in a direction intersecting with the leg-opening elasticized area,
the leg-opening elasticized area has a plurality of leg-elastic members extending in the vertical direction and at a predetermined interval in the lateral direction,
the leakage-barrier cuff has a free edge parallelly-spaced in the lateral direction from the cuff branch line so as to extend in the vertical direction,
a distance from the cuff branch line to the distal edge is larger than a distance from the cuff branch line to the free edge,
the number of sheet material layers included in the leg-opening elasticized area is larger than the number of the sheet material layers included in the leakage-barrier cuff, and
a single leg-elastic member, among the plurality of leg-elastic members, overlaps the cuff branch line in a thickness direction perpendicular to the lateral direction and the vertical direction.

US Pat. No. 10,966,878

MALE INCONTINENCE GUARD AND METHOD FOR MANUFACTURING A MALE INCONTINENCE GUARD

ESSITY HYGIENE AND HEALTH...

1. A male incontinence guard comprising a fluid-impermeable backsheet, a fluid-permeable topsheet and an absorbent body arranged between said backsheet and said topsheet,wherein said topsheet faces the user when the incontinence guard is worn by said user, said guard having a longitudinal extension along a longitudinal axis (Y1) and a transverse extension along a transverse axis (X1), said transverse axis (X1) dividing said guard into an upper region and a lower region, wherein said transverse axis (X1) extends between a first lower corner point and a second lower corner point which define two outermost points of said guard between which said guard has a first width;
said upper region comprising an inwardly recessed curvature portion extending between a first upper corner point and a second upper corner point and having an arcuate shape, said upper corner points defining a second width (w2);
wherein the first width (w1) is greater than the second width (w2), and wherein said first lower corner point and first upper corner point and said second lower corner point and second upper corner point, respectively, are connected by outer side edges, and wherein said guard is arranged having elasticized elements arranged along outer edges of said lower region, and wherein the ratio between the first width (w1) and the second width (w2) is in the range of 30-80%, and wherein the ratio between a distance (d1) defined by an imaginary longitudinal line (Y2), being parallel to said longitudinal axis (Y1) and extending from any one of said upper corner points to said transversal axis (X1), and a distance (d2) extending from any one of said lower corner points to said longitudinal line (Y2), is in the range of 0.25-4.0, wherein a straight line is defined as extending through a lower corner point and an upper corner point, and wherein an angle (?) is defined between said straight line and said imaginary longitudinal line (Y2), said angle (?) being in the range of 12-78 degrees, and wherein a measurement (d4) is defined as a distance between said straight line and a maximum outer extension of said incontinence guard, wherein said measurement (d4) is less than 25% of a distance between first lower corner point and the first upper corner point; and
wherein said inwardly recessed curvature portion defines an outer boundary edge extending between said upper corner points and wherein said outer boundary edge lies inwardly of an imaginary transverse line (X2) extending between said upper corner points.

US Pat. No. 10,966,877

METHOD FOR ASSEMBLING PRODUCTS IN A MANUFACTURING PROCESS

1. A method for assembling products in manufacturing process, the method comprising the steps of:providing a sensor, the sensor including a sensor clock;
providing a controller, the controller including a controller clock;
synchronizing the sensor clock with the controller clock such that the reported time of the controller clock and the sensor clock are correlated;
advancing a substrate in a machine direction through a converting process;
virtually segmenting the substrate into a plurality of virtual segments;
combining component parts with the substrate;
inspecting at least one of the substrate and component parts with the sensor;
communicating inspection parameters from the sensor to the controller;
assigning a timestamp to each inspection parameter, each timestamp based on the sensor clock;
receiving the inspection parameters and corresponding timestamps from the sensor into the controller;
correlating each inspection parameter with one virtual segment based on the timestamp of the inspection parameter;
identifying component positions in virtual segments based on the inspection parameters;
adjusting the placement of the component parts on the substrate; and
converting the substrate into discrete articles.

US Pat. No. 10,966,876

METHODS AND APPARATUSES FOR ASSEMBLING ELASTIC LAMINATES WITH DIFFERENT BOND DENSITIES FOR ABSORBENT ARTICLES

1. A method for assembling elastic laminates, the method comprising steps of:providing a first substrate and a second substrate, the first substrate and the second substrate each comprising a first surface and an opposing second surface, a first longitudinal edge and a second longitudinal edge separated from the first longitudinal edge to define a width in a cross direction;
providing a first elastic film and a second elastic film, each of the first elastic film and the second elastic film comprising a stretched central region;
positioning the stretched central region of the first elastic film in contact with the second surface of the first substrate;
positioning the stretched central region of the second elastic film in contact with the second surface of the first substrate;
forming an elastic laminate by advancing the second substrate in a machine direction to position the first surface of the second substrate in contact with the stretched central regions of the first and second elastic films, wherein the elastic laminate comprises a first bonding region and a second bonding region, wherein the first bonding region is defined where the stretched central region of the first elastic film is in direct contact with the second surface of the first substrate and the first surface of the second substrate, and wherein the second bonding region is positioned completely outside the first bonding region;
applying a first plurality of ultrasonic bonds to the elastic laminate to define a first bond density in the first bonding region; and
applying a second plurality of ultrasonic bonds to the elastic laminate to define a second bond density in the second bonding region, wherein the first bond density is not equal to the second bond density and wherein the elastic laminate comprises at least one more layer in the second bonding region than in the first bonding region.

US Pat. No. 10,966,875

APPARATUS AND METHOD FOR STRETCHING AND REPITCHING ELASTIC MEMBERS

ONTEX BV, Buggenhout (BE...

1. Method for stretching and repitching an elastic member for attachment to a moving substrate, the elastic member being stretchable in at least a longitudinal direction and said elastic member in an essential non-stretched condition comprising an initial length along said longitudinal direction, the method comprising the steps of:(1) providing the elastic member in essentially non-stretched condition to a set of repitching members with an initial supply pitch, said set of repitching members comprising at least a first repitching member and a second repitching member;
(2) receiving said elastic members arranged in non-stretched condition between said set of repitching members, whereby the distance between the first and the second repitching member corresponds to the initial length of the elastic member;
(3) moving at least said first and said second repitching members following trajectories diverging from each other, thereby stretching said elastic members arranged between the repitching members to an application length which is longer than the initial length and which corresponds to the length of said elastic member in elastically stretched condition,
whereby said repitching members are moved with selectively variable velocity when transferring said elastic members to selectively vary the application pitch of said elastic member in stretched condition on said substrate, the variation of the speed of said repitching members determining the application pitch of said elastic member in stretched condition on said substrate,
characterized in that during step (3), said set of repitching members are rotated around a common rotation axis while the elastic member is being stretched from the initial length to the application length.

US Pat. No. 10,966,874

ABSORBENT ARTICLE(S) CHASSIS COMPRISING BEAMED ELASTICS

1. An extensible article, comprising:a front waist edge;
a back waist edge;
a longitudinal axis extending from the midpoint of the front waist edge to the midpoint of the back waist edge;
a lateral axis extending perpendicular to the longitudinal axis through the midpoint of the longitudinal axis;
a first elastomeric laminate forming at least a portion of a belt, a side panel, or an ear panel in a first waist region, the first elastomeric laminate comprising a first plurality of elastics;
a second elastomeric laminate forming at least a portion of a belt, a side panel, or an ear panel in a second waist region, the second elastomeric laminate comprising a second plurality of elastics;
a third elastomeric laminate formed by two substrate layers forming at least a portion of the chassis in a crotch region, the third elastomeric laminate comprising a third plurality of elastics;
wherein the first plurality of elastics comprises greater than about 40 elastic strands, the second plurality of elastics comprises greater than about 40 elastic strands, and the third plurality of elastics comprises greater than about 10 elastic strands;
wherein each of the first plurality of elastics, second plurality of elastics, and third plurality of elastics have an Average-Strand-Spacing from about 0.25 mm to about 4 mm;
wherein the Average-Pre-Strain of each of the first plurality of elastics, second plurality of elastics and third plurality of elastics is from about 50% to about 400%;
wherein the Average-Dtex of each of the first plurality of elastics, second plurality of elastics, and third plurality of elastics is from about 10 to about 500;
wherein the third plurality of elastics has one or more of: a) an Average-Strand-Spacing that is greater than one or both of the first and second plurality of elastics, b) an Average-Dtex that is lower than one or both of the first and second plurality of elastics, c) an Average-Pre-Strain that is lower than one or both of the first and second plurality of elastics, and d) a number of elastics that is lower than one or both of the first and second plurality of elastics;
wherein the elastic strands of each of the first plurality of elastics and second plurality of elastics are disposed substantially parallel to the lateral axis; and
wherein the elastic strands of the third plurality of elastics is disposed substantially parallel to the longitudinal axis.

US Pat. No. 10,966,873

METHODS AND APPARATUSES FOR MAKING ELASTOMERIC LAMINATES WITH ELASTIC STRANDS UNWOUND FROM SPOOLS ON SURFACE UNWINDERS

1. A method for making an elastomeric laminate, the method comprising steps of:providing first spools, each first spool comprising an outer circumferential surface defined by an elastic strand wound onto a core;
positioning the outer circumferential surface of each first spool in rolling contact with a first roll;
providing second spools, each second spool comprising an outer circumferential surface defined by an elastic strand wound onto a core;
positioning the outer circumferential surface of each second spool in rolling contact with a second roll;
unwinding elastic strands from the first spools by advancing the elastic strands from between each first spool and the first roll;
stretching the elastic strands from the first spools, wherein the elastic strands from the first spools comprise first elastic strands and second elastic strands;
bonding the stretched first elastic strands and stretched second elastic strands from the first spools with and between a first substrate and a second substrate to form an elastomeric laminate, wherein the elastomeric laminate comprises a first region having a first stretch characteristic defined by the first elastic strands and a second region having a second stretch characteristic defined by the second elastic strands, wherein the first stretch characteristic is different from the second stretch characteristic;
unwinding elastic strands from the second spools by advancing the elastic strands from between each second spool and the second roll;
connecting the elastic strands from the second spools with a splicer member;
combining the splicer member and the elastic strands from the second spools with the elastic strands from the first spools between the first and second substrates; and
subsequently discontinuing unwinding of the elastic strands from the first spools.

US Pat. No. 10,966,872

ABSORBENT DRESSING AND METHOD

KCI Licensing, Inc., San...

1. A dressing adapted to distribute reduced pressure from a reduced-pressure source to a tissue site, comprising:a storage layer adapted to absorb fluid communicated from the tissue site;
a fluid communication channel disposed through the storage layer; and
a retainer disposed in the fluid communication channel, wherein the retainer is adapted to substantially preclude deformation of the storage layer into the fluid communication channel, and wherein the retainer comprises a porous, hydrophobic material.

US Pat. No. 10,966,871

VACUUM BANDAGE PACKING

KCI Licensing, Inc., San...

6. A system for providing vacuum therapy to a tissue site, the system configured for fluid communication with a vacuum source to provide reduced pressure to the tissue site, the system comprising;a pack configured to provide at least a portion of a route of fluid communication between the vacuum source and the tissue site, and having an adhesive on a lower surface of the pack;
a member having a plurality of holes fluidly coupled to the pack and configured to define a plurality of fluid pathways for providing at least a portion of the route of fluid communication between the vacuum source and the tissue site, wherein the member includes a plurality of protrusions extending away from the member toward the tissue site.

US Pat. No. 10,966,870

EVAPORATIVE FLUID POUCH AND SYSTEMS FOR USE WITH BODY FLUIDS

KCI Licensing, Inc., San...

1. An inline storage-and-liquid-processing pouch for use with body fluids from a patient, the inline storage-and-liquid-processing pouch comprising:a pouch body comprising a first chamber and a second chamber;
a first port and a second port in fluid communication with the first chamber, wherein the second port is adapted to fluidly couple the first chamber to a reduced-pressure source; and
a first evaporation port and a second evaporation port in fluid communication with the second chamber, wherein the second evaporation port is adapted to fluidly couple the second chamber to a pressure source.

US Pat. No. 10,966,869

COMBINATION SIS AND VACUUM BANDAGE AND METHOD

KCI Licensing, Inc., San...

1. A wound care bandage for use with a vacuum source, the wound care bandage comprising:a cover having an aperture and configured for placement over a wound to provide a vacuum space around the wound;
a collagen-containing layer configured for placement on the wound within the vacuum space;
a porous pad configured for placement between the collagen-containing layer and the cover within the vacuum space, the porous pad being removable from the wound and having a plurality of fluid passageways; and
an adhesive adapted to couple the cover to skin around the wound to hold the porous pad and the collagen-containing layer in place within the vacuum space.

US Pat. No. 10,966,868

HEARING PROTECTOR WITH CURVED SEGMENTS

3M Innovative Properties ...

1. A hearing protector, comprising:a sound attenuating element; and
a stem comprising:
a proximal end and a proximal portion adjacent the proximal end, the proximal portion extending along a first longitudinal axis into the sound attenuating element;
a distal end and a distal portion adjacent the distal end, the distal portion extending along a second longitudinal axis and forming a handle, wherein the second longitudinal axis and the first longitudinal axis are not parallel to one another, and the proximal portion and the distal portion connect to form a plurality of angles disposed outside of the sound attenuating element.

US Pat. No. 10,966,867

PUSH-IN EARPLUG

3M Innovative Properties ...

1. An earplug comprising:an elongate core comprising a first material and having first and second ends and an outer major surface; and
an outer layer comprising a second material and covering at least a portion of the outer major surface of the elongate core, wherein the outer layer comprises an at least partially activated foaming agent and at least one of an uncured rubber, partially cured rubber, thermoset polymer, or thermoplastic elastomer;
wherein the outer layer comprises a sound attenuating portion having a first average density ?1 and a stem portion having a second average density ?2, wherein |?2>1.2 ?1|, and wherein density of the first material is substantially constant across a length of the earplug.

US Pat. No. 10,966,866

TYMPANOSTOMY TUBE DELIVERY DEVICE WITH ROTATABLE FLEXIBLE SHAFT

TUSKER MEDICAL, INC., Me...

1. A method, comprising:advancing a tip of an elongate tube of a shaft assembly through an ear canal of a patient to engage the tip with a tympanic membrane of the patient, the shaft assembly extending distally from a handpiece body, the elongate tube having a proximal section defining a longitudinal axis and a bent section disposed between the proximal section and the tip, the bent section maintaining the tip at a non-zero angle relative to the longitudinal axis;
rotating the elongate tube relative to the tympanic membrane prior to engaging the tip of the elongate tube with the tympanic membrane; and
actuating a drive assembly disposed within the handpiece body to longitudinally translate a plurality of shafts of the shaft assembly relative to the elongate tube of the shaft assembly and through the bent section in a predetermined sequence to at least one of pierce the tympanic membrane or deploy a tympanostomy tube in the tympanic membrane.

US Pat. No. 10,966,865

FEMTOSECOND LASER DOCKING APPARATUS

Alcon Inc.

1. A femtosecond laser docking apparatus comprising:a suction cone including an upper frusto-conical portion and a lower spherical portion; and
a suction ring including a spherical portion and a mechanical stop that extends at least partially around a circumference of a top of the suction ring, the mechanical stop having an upper diameter; the suction ring engaging the lower spherical portion of the suction cone; the mechanical stop preventing the suction cone from being lowered further toward an eye, in a z-direction, beyond the mechanical stop;
wherein the spherical portion of the suction ring engages the lower spherical portion of the suction cone such that the lower spherical portion of the suction cone swivels with respect to the suction ring until the suction cone engages the mechanical stop.

US Pat. No. 10,966,864

PATIENT INTERFACE DEVICE FOR OPHTHALMIC SURGICAL LASER SYSTEM

AMO Development, LLC, Sa...

1. A patient interface device for coupling an eye of a patient to an ophthalmic surgical laser system, comprising:a hollow shell formed of a rigid material and defining an interior space, the shell having an upper rim and a lower portion;
a transparent applanation lens disposed inside of and fixedly mounted to the lower portion of the hollow shell; and
a flexible skirt having a circular shape, the flexible skirt being affixed to and extending downwardly from a lower end of the lower portion of the shell, wherein a lower rim of the flexible skirt is located below the applanation lens,
wherein the lower portion of the shell defines one or more through channels in a region between the applanation lens and a side wall of the lower portion, wherein each of the one or more through channels is open to and in air communication with both the interior space of the shell above the applanation lens and a space which is located below the applanation lens and encircled by the flexible skirt wherein each of the one or more through channels is configured to communicate a vacuum to secure the patient interface device to the ophthalmic surgical laser system and to the eye.

US Pat. No. 10,966,863

TREATMENT TO IMPROVE ADHESIVE PROPERTIES OF CORNEAL IMPLANT

Eyeyon Medical Ltd., Nes...

1. A method comprising:improving adhesion of an ocular implant to corneal tissue by forming an implant adhesive layer on said ocular implant, said implant adhesive layer having greater adhesive strength than a rest of the implant, wherein forming said implant adhesive layer is done by making chemical and/or physical changes on an anterior surface of said implant that make said implant adhesive layer more adhesive than the rest of said implant, and wherein forming said implant adhesive layer is done by application of laser energy on the anterior surface of said implant.

US Pat. No. 10,966,862

OPHTHALMIC LASER TREATMENT APPARATUS

NIDEK CO., LTD., Gamagor...

1. An ophthalmic laser treatment apparatus for generating plasma by focusing a treatment laser beam to treat a treatment target portion of a patient's eye with the plasma, the apparatus comprising:an irradiation optical system configured to irradiate the treatment laser beam to the patient's eye;
an aiming optical system configured to irradiate an aiming beam to the patient's eye;
a position adjusting unit comprising at least one lens and configured to adjust a focusing position of the treatment laser beam in an optical axis direction with respect to a predetermined reference position that is a focusing position of the aiming beam;
an energy adjusting unit comprising a ½ wave plate and configured to adjust irradiation energy of the treatment laser beam by driving a motor to rotate the ½ wave plate;
a memory configured to store evaluation information to evaluate a permissible combination of the focusing position of the treatment laser beam and the irradiation energy with respect to the focusing position of the treatment laser beam; and
a processor configured to evaluate a combination of the focusing position of the treatment laser beam adjusted by the position adjusting unit and the irradiation energy adjusted by the energy adjusting unit based on the evaluation information, wherein
the energy adjusting unit is configured to reduce, by driving the motor to rotate the ½ wave plate, the irradiation energy as the focusing position of the treatment laser beam approaches the predetermined reference position.

US Pat. No. 10,966,861

APPARATUS AND METHOD FOR MAINTAINING ENTHALPY WITH SECONDARY MECHANISMS

1. An interactive enthalpy exchange system for infant care comprising:a pouch configured as a wrap, wherein the pouch is wrappable around an infant;
a temperature sensor for measuring a skin temperature of the infant;
a heat source arranged in the pouch, the heat source including a first heat source and a second heat source different from the first heat source; and
control circuitry operatively coupled to the heat source, the control circuitry configured to control interactive enthalpy between the first heat source and the second heat source to maintain a temperature within the pouch at a prescribed temperature, the control circuitry further configured to control an amount of power provided to the heat source based on the skin temperature measured by the temperature sensor, wherein the control circuitry is configured to provide uniform heat transfer by conduction to the infant placed in the pouch by exchanging enthalpy among the heat sources based on a temperature outside the pouch.

US Pat. No. 10,966,860

URINE MEASURING VESSEL AND HOSE CONNECTION

1. An apparatus for measuring body liquids comprising;a measuring vessel with a liquid inlet at a top end of the measuring vessel and a liquid outlet at a lower end of the measuring vessel, the measuring vessel comprising a curved inside bottom surface at the lower end provided at each side of a central column,
a measuring scale for reading a volume of urine inside the measuring vessel,
filling elements disposed inside the measuring vessel and above the curved inside bottom surface of the measuring vessel and taking up a predefined volume of the measuring vessel to compensate for the curved bottom surface of the measuring vessel in order to allow for use of a linear measuring scale,
a valve provided with the liquid outlet and a liquid collection bag connected to the liquid outlet and suspended from the measuring vessel, and
a hollow valve body placed in and vertically displaceable with the measuring vessel, the liquid outlet having a shape of a valve seat for the hollow valve body, an interior of the valve body being divided into a reception chamber and an overflow chamber, said reception chamber being connected to the liquid inlet and having at a lower end of the valve body at least one outlet opening which in a closed position of the valve body is closed by the valve seat and which at an upper part of the valve body is connected to the measuring vessel through at least one hole in a chamber wall, the overflow chamber having at a lower end of the overflow chamber a duct which is directly connected to the measuring vessel via a hole in the chamber wall, the holes connecting the reception chamber to the measuring vessel and the measuring vessel to the overflow chamber being placed on a same side of the hollow valve body.

US Pat. No. 10,966,859

FORCE DISTRIBUTION METHOD AND APPARATUS FOR NEONATES AT RISK OF CRANIAL MOLDING

Invictus Medical, Inc., ...

1. A force-distributing cranial support suitable for a head of an infant comprising:an occipital cup portion and an operatively attached head strap portion, said occipital cup portion and said head strap portion having a caudal edge adapted to be oriented towards a neck of an infant and a cephalic edge adapted to be oriented towards a crown of said head of said infant, wherein said force-distributing cranial support has a patient oriented face and an environmental oriented face, said patient oriented face comprising a material having hypoallergenic, biocompatible, non-irritating properties;
a gel assembly oriented within said occipital cup portion, said gel assembly comprising a semi-solid material, said semi-solid material adapted to distribute a force of said head of said infant applied thereon, said semi-solid material containedly oriented within said gel assembly; and
a padded layer, said gel assembly proximate said padded layer, wherein said padded layer and said gel assembly are elements of said occipital cup portion of said force-distributing cranial support;
wherein said head strap portion is configured relative to said occipital cup such that said head strap portion is snugly conformable to a forehead of said infant while said occipital cup portion is operatively positioned adjacent to an occipital region of said head of said infant, said cephalic edge adapted to be positioned below said crown of said head of said infant, whereby said crown of said head of said infant is uncovered.

US Pat. No. 10,966,858

SUPPORT STRUCTURE

University of Strathclyde...

1. A support for supporting a wrist of a wearer, the support comprising: at least one rigid first support member for locating on an upper side of a forearm and wrist in use,at least one fixing device for attaching the support to the wearer, and at least one rigid second support member extending at an angle from the at least one rigid first support member, wherein:
the at least one rigid first support member comprises:
a longitudinally extending rigid center part that is configured to extend rigidly along, and sit on top of, at least part of the forearm and part of the wrist of the wearer; and
a rigid sloping section forming an end of the at least one rigid first support member, the rigid sloping section being configured to cover an upper side of part of the wrist and at least a portion of an upper hand, the rigid sloping section sloping in a longitudinal direction of the at least one rigid first support member, the longitudinally extending rigid center part transitioning into the rigid sloping section such that the rigid sloping section is adjacent and angled to the longitudinally extending rigid center part and the at least one rigid first support member as a whole is non-elastic;
the at least one rigid second support member comprises at least a first part and a second part;
the first part of the at least one rigid second support member is integral with or fixed to the rigid sloping section of the at least one rigid first support member and extends obliquely away from the rigid sloping section of the at least one rigid first support member that the at least one rigid second support member is integral with or fixed to, at least partly in a direction that is perpendicular to both the longitudinal direction and a lateral direction of the at least one rigid first support member, to the second part of the at least one rigid second support member, which extends generally laterally from the first part;
the at least one rigid second support member has a terminal or distal end that is configured to support a palm of a hand of the wearer such that at least part of the hand lies between the terminal or distal end of the at least one rigid second support member and the rigid sloping section of the at least one rigid first support member in use;
the at least one rigid second support member arranged to extend along the palm of the wearer in use and is free at said terminal or distal end thereof; and
the support is configured such that, in use, an ulnar side of the wrist and hand of the wearer are not covered by the support and are left open;
wherein the rigid sloping section is angled between 10 and 20 degrees from an adjacent part of the at least one rigid first support member.

US Pat. No. 10,966,857

WRIST BRACE WITH ENHANCED LACING

Medical Specialties, Inc....

15. A wrist brace, comprising:a U-shaped support sleeve having a dorsal section, an ulnar section, and a palmar section, wherein the ulnar section is contiguously positioned between the dorsal section and the palmar section;
a radius panel connecting the U-shaped support sleeve's dorsal section and the U-shaped support sleeve's palmar section, the radius panel being affixed to the U-shaped support sleeve such that together the U-shaped support sleeve and radius panel form a closed wrist-brace sleeve;
dorsal lace-redirection mechanisms positioned at or near the U-shaped support sleeve's dorsal section;
palmar lace-redirection mechanisms positioned at or near the U-shaped support sleeve's palmar section;
a lacing closure tab having one or more closure-tab lace-redirection mechanisms;
a lace having (i) a first end fixedly connected to the U-shaped support sleeve's palmar section and (ii) a second end fixedly connected to the U-shaped support sleeve's palmar section, and
wherein, in a direction along a length of the palmar section, the palmar lace-redirection mechanisms are positioned between the lace's first end and the lace's second end.

US Pat. No. 10,966,856

FOAM CORE SANDWICH SPLINT

DJO, LLC, Vista, CA (US)...

17. A composite material, comprising:a first layer of thermoformable material having a thickness of 0.03 to 0.075 inches, the first layer of thermoformable material being heat formable such that it is at least partially shapeable once heated to within a target temperature range;
a second layer of thermoformable material being heat formable such that it is at least partially shapeable once heated to within a target temperature range; and
a foam layer disposed between the first layer of thermoformable material and the second layer of thermoformable material, the foam layer having a lower density that the first layer of thermoformable material and a lower density that the second layer of thermoformable material.

US Pat. No. 10,966,855

ORTHOSIS

THUASNE UK LIMITED, Tunb...

1. An orthosis comprising a first portion which comprises a polymer reinforced with a plurality of first fibres, and a trimmable second portion which is disposed around at least a section of a peripheral edge of the orthosis and comprises a polymer reinforced with a plurality of second fibres, wherein the first portion has a higher tensile strength and is harder than the second portion, and wherein the second portion comprises a pigment and/or a dye which affects the colour of the second portion, wherein the pigment and/or dye is selected to ensure that the second portion is visually distinct from the first portion, so that in use the trimmable area of the second portion is easily identified and can be trimmed to enable the orthosis to better fit a user.

US Pat. No. 10,966,854

BRACE WITH A VARIABLE RESISTANCE BAND SYSTEM

1. A rehabilitation system comprising:a brace having an upper arm and a lower arm gearably mated with the upper arm such that rotation of the upper arm causes the lower arm to counter-rotate in lockstep;
a first gear attached to the upper arm such that the first gear rotates in lockstep with rotation of the upper arm;
a second gear attached to the lower arm such that the second gear rotates in lockstep with rotation of the lower arm;
a variation piece having a head and a stem, the stem having a first set of teeth that mesh with the first gear and a second set of teeth that mesh with the second gear such that rotation of the first gear and the second gear causes the variation piece to linearly travel in a first direction and counter-rotation of the first gear and the second gear causes the variation piece to travel in a second opposing direction; and
a first resistance band having a first end attached to the upper arm of the brace and a second end attached to the lower arm and a medial section received by the head of the variation piece.

US Pat. No. 10,966,853

SHOULDER AND ARM ORTHOSIS

Elizur Corporation, Pitt...

1. An orthosis assembly for supporting at least one of a shoulder, arm, wrist and hand of a user comprising:a sling comprising attached inner and outer portions, wherein said inner and outer portions are configured to be detached and reattached;
a wrist/hand orthosis supported by said sling; a strap connected to said sling and configured to support said sling;
an abduction pillow configured to be removably attached to said inner portion of said sling and positioned between said sling and a torso of the user to maintain said sling in a desired position relative to the torso of the user; and
at least one resistance band configured to attach between said sling and said wrist/hand orthosis which is configured to resist movement of said wrist/hand orthosis relative to said sling, so that exercises for strengthening the at least one of a shoulder, arm, wrist, and hand can be performed by a user.

US Pat. No. 10,966,852

HEEL ANKLE SUPPORTER

1. A heel ankle supporter having elasticity attachable to a foot of a human body, comprising:a sleeve supporter which can cover a surface of a region including an instep, a sole, a heel and an ankle of the foot; and a belt-type-supporter-which is fixed to the sleeve supporter and attachable to the foot on the sleeve supporter, wherein
the belt-type supporter is provided with an ankle belt, a plantar heel hold belt, an affected-part pressing belt, and a posterior heel hold belt which are respectively formed into a belt-shape:
the ankle belt is fixable to the ankle by being wound around the ankle above a medial malleolus and a lateral malleolus of the foot:
in the plantar heel hold belt, one end in a longitudinal direction is fixed to the ankle belt so as to extend downward from the ankle belt from the one end toward the other end; the plantar heel hold belt is provided with: an inner cover part configure to continue from the ankle belt so as to cover a vicinity of the medial malleolus; a plantar cover part configured to continue from the inner cover part so as to cover the sole at a front of a calcaneus; and an outer cover part configured to continue from the plantar cover part so as to cover a vicinity of the lateral malleolus:
the other end of the plantar heel hold belt is fixed to an outer surface of the ankle belt so that the plantar heel hold belt is fixable to the foot passing through the sole in extended state:
the affected-part pressing belt is fixed to the plantar heel hold belt at one end in a longitudinal direction, configured to extend diagonally forward in a direction gradually separated from the plantar heel hold belt from the one end to the other end, and provided with of pressing part which is wound in a direction from an outside of the foot to an inside of the foot through the instep side so as to cover an affected part:
the other end of the affected-part pressing belt is fixed to any ore of outer surfaces of the ankle belt, the plantar heel held belt or the affected-part pressing belt in a middle position along a longitudinal direction so as to be fixed to the foot and cover the affected part in an extended state:
the posterior heel hold belt is fixed to the plantar heel hold belt below the medial malleolus and the lateral malleolus at one end in a longitudinal direction; configured to extend backward from the plantar heel hold belt parallel to the ankle belt, provided with a posterior cover part so as to cover a posterior part of a vicinity of the calcaneus; and fixed to an outer surface of the outer cover part at the other end so as to be fixed to the heel of the foot covering the posterior part in an extended state: and
the sleeve supporter is made of cloth which is more elastic than the belt-type supporter, and a thickness of yarn used for it is not smaller than 30 denier and not more than 70 denier, clothing pressure is not less than 10 mmHg but not more than 20 mmHg, and wherein
the belt-type supporter is detachable to the sleeve supporter, and the sleeve supporter has belt loops in which the ankle belt is passed through and held.

US Pat. No. 10,966,851

ORTHOPEDIC DEVICE

OSSUR ICELAND EHF, Reykj...

1. A knee support, comprising:a first zone and a second zone, wherein the first zone has greater compressibility and less elasticity than the second zone, the first zone adapted to extend distally about a tibia of a user and extend proximally of a knee, the second zone extending above the first zone and adaptive to extend about a femur of the user; and
a third zone surrounded by the first zone on proximal and distal sides, and on medial and lateral sides of the third zone on an anterior side of the knee support, the third zone having greater flexibility than the first and second zones and adapted to extend over a patella of the user;
wherein the first, second and third zones are formed from segments of knitted textile.

US Pat. No. 10,966,850

IMPLANTABLE MEDICAL DEVICE CONSTRAINT AND DEPLOYMENT APPARATUS

1. A medical device deployment system comprising:an expandable medical device having first and second ends and having a larger deployed diameter, and a smaller compacted diameter in a delivery configuration adapted for advancement through a vasculature of a patient;
a sheath surrounding the expandable medical device in the delivery configuration, said sheath everted back over itself, wherein an outer portion of said sheath surrounds an inner portion of said sheath, the sheath being split at a trailing end to form a deployment line;
a filamentary constraining member positioned between the inner and outer portions of the sheath in the delivery configuration such that the outer portion of the sheath surrounds the constraining member from the first end to at least the second end of the expandable medical device, and the filamentary constraining member including a cord configured to be tensioned to unravel the constraining member, wherein the expandable medical device is deployed to the larger deployed diameter by application of simultaneous actuation forces to the sheath and the cord of the filamentary constraining member.

US Pat. No. 10,966,849

INDWELLING MEDICAL DEVICE HAVING BISTABLE STRUCTURE IN LUMEN ORGAN

YAMAGUCHI UNIVERSITY, Ya...

1. An indwelling medical device for a luminal organ in which a plurality of struts connected with each other are arranged to form a cylindrical shaped body having a network structure as a whole, whereineach strut is composed by connecting a plurality of strut pieces integrally via hinges and is deformed to be elongated in a circumferential direction of the indwelling medical device corresponding to expansion of a diameter of the device,
each strut has at least one set of strut pieces having a bistable structure supporting a load acting to reduce the diameter of the device in a state where the set of strut pieces is deformed from one stable state through snap-through buckling deformation to another stable state in a process of elongation in the circumferential direction and the other strut pieces in the strut are connected so as to provide action to induce snap-through buckling deformation of the at least one set of the strut pieces having the bistable structure in the process of elongation of the strut in the circumferential direction, and
the load acting to reduce the diameter of the device after snap-through buckling deformation brings action preventing the at least one set of strut pieces having the bistable structure from creating snap-through buckling deformation in a reverse direction, so that an expanded diameter state of the device is held.