US Pat. No. 10,597,530

POLYCARBONATE COMPOSITIONS WITH IMPROVED FLAME RETARDANCE

SABIC GLOBAL TECHNOLOGIES...

1. A flame retardant composition, comprising:a first polycarbonate polymer having repeating units derived from a monomer having the structure of Formula (A) or Formula (B):
whereinR and R? are C2-C15 alkyl;
m, n, p, and q are each 0 or 1, m+n=1, and p+q=1; and
E is C1-C15 alkyl; and
about 0.05 to about 0.5 wt. % of a flame retardant additive, wherein the flame retardant additive is an alkali metal salt of a perfluorinated C1-C16 alkyl sulfonate, potassium diphenylfone sulfonate, sodium benzene sulfonate, sodium toluene sulfonate, or a cyclic siloxane having the formula [(R?)2SiO]y wherein R? wherein R is a monovalent hydrocarbon or fluorinated hydrocarbon having from 1 to 18 carbon atoms and y is a number from 3 to 12,
wherein the first polycarbonate is un-crosslinked.

US Pat. No. 10,597,517

CURABLE RESIN COMPOSITION AND SEALING MATERIAL USING SAME

Nippon Shokubai Co., Ltd....

1. A curable resin composition, comprising:a cyanate ester compound;
a maleimide compound;
a dehydrating agent,
wherein the dehydrating agent is aliphatic polycarbodiimide; and
a siloxane compound represented by the following average composition formula (6):
XaYbZcSiOd  (6),
wherein each X is the same or different and represents an organic structure containing an imide bond; each Y is the same or different and represents at least one selected from the group consisting of a hydrogen atom, a hydroxy group, a halogen atom, and an OR group; each Z is the same or different and represents an organic group containing no imide bond; each R is the same or different and represents at least one selected from the group consisting of an alkyl group, an acyl group, an aryl group, and an unsaturated aliphatic residue, and may have a substituent; the coefficient a of X satisfies 0

US Pat. No. 10,597,515

POLYCYCLIC GLYOXYLATES AS PHOTOINITIATORS

IGM GROUP B.V., RM Waalw...

1. A photopolymerizable composition comprising:(A) at least one ethylenically unsaturated photopolymerizable compound and
(B) at least one photoinitiator compound of formula (1)

wherein
X is O, S or a direct bond;
Y is O, S or CR9R10;
R1, R2, R3, R4, R5, R6, R7 and R8 independently of each other are hydrogen, halogen, C1-C18alkyl, C5-C10cycloalkyl, C2-C18alkenyl, phenyl, C1-C4alkoxy, C5-C7cycloalkoxy, phenoxy, C1-C4-alkylthio, C5-C7cycloalkylthio, phenylthio, di(C1-C4alkyl)amino, di(C5-C7cycloalkyl)amino, N-morpholinyl, N-piperidinyl or a group of formula (2)

provided that one or more than one of R1, R2, R3, R4, R5, R6, R7 or R8 is a group of formula (2);
R9, R10 independently of each other are hydrogen, C1-C18alkyl, C2-C12alkenyl, C5-C10cycloalkyl, phenyl-C1-C4alkyl, phenyl or together with the C atom to which they are attached form a 5-membered, 6-membered or 7-membered ring; and
R11 is hydrogen, C1-C18alkyl, C5-C10cycloalkyl, C2-C12alkenyl, phenyl, or phenyl-C1-C4alkyl.

US Pat. No. 10,597,514

COMPOSITION COMPRISING POLY-LACTIDE-BASED POLYMER

1. A composition comprising:(a) at least one poly-lactide comprising polymer selected from the group consisting of poly-lactide, poly-lactide-polybutadiene block copolymer, poly-lactide-urethane-polybutadiene block copolymer, poly-lactide-urethane, and mixtures thereof;
(b) at least one compound of formula (I),

wherein,
L1 is C1-8 alkylene or C3-6 cycloalkylene
L2 is C1-6 alkylene;
L3 is C1-6 alkylene;
L4 is C1-6 alkylene;
L5 is C1-6 alkylene;
n is an integer selected from 1, 2, 3 or 4;
m is an integer selected from 1, 2, 3 or 4;
R1 is H or C1-6alkyl;
R2 is H or C1-6alkyl;
wherein the poly-lactide in said poly-lactide comprising polymer is selected from the group consisting of poly-L-lactide comprising a content of D isomer of at least 25% by weight based on the total weight of the poly-L-lactide; poly-D-lactide comprising a content of L isomer of at least 25% by weight based on the total weight of the poly-D-lactide; and mixtures thereof.

US Pat. No. 10,597,512

OPTOELECTRONIC DEVICE WITH A MIXTURE HAVING A SILICONE AND A FLUORO-ORGANIC ADDITIVE

OSRAM OPTO SEMICONDUCTORS...

1. An optoelectronic device comprising:at least one radiation-emitting or radiation-detecting semiconductor; and
a mixture comprising silicone and a fluoro-organic additive, wherein the mixture is a component of at least one of the following elements:
a package body element surrounding the at least one semiconductor at least in places,
a radiation-guiding element arranged in a beam path of a radiation emitted by the semiconductor or detected by the semiconductor,
a heat-conducting element configured to conduct heat emitted by the semiconductor or received by the semiconductor,
an adhesive element.

US Pat. No. 10,597,492

DIALKYL-POLYALKYLAMINE COMPOSITIONS, PROCESS FOR THEIR PREPARATION AND THEIR USE

NOURYON CHEMICALS INTERNA...

1. Di-fatty-alkyl(ene) polyalkylamine composition which comprises a mixture of polyalkylamines selected from products with formulae (I) and (II),
wherein each R is, independent of the other R, an alkyl or alkylene moiety with 8-22 carbon atoms, n and z are independent of each other either 0, 1, 2, or 3, and when z>0 then o and p are independent of each other either 0, 1, 2, or 3, or derivatives thereof, whereby said mixture comprises a) a total of at least 3% by weight of branched compounds of formula (I) with at least one of n and z>=1 and products of formula (II) with n>=1, and b) a total of at least 5% by weight of products of formula (I) with n and z=0, and compounds of formula (II) with n=0.

US Pat. No. 10,597,491

METAL FINE PARTICLE DISPERSANT CONTAINING BRANCHED POLYMER COMPOUND HAVING AMMONIUM GROUP

NISSAN CHEMICAL CORPORATI...

1. A complex comprising:a metal fine particle dispersant comprising a branched polymer compound having an ammonium group and having a weight average molecular weight of 500 to 5,000,000; and
a metal fine particle, wherein
the metal fine particle comprises platinum (Pt) or palladium (Pd),
the metal fine particle dispersant comprises a branched polymer compound of Formula (1):

wherein
R1 is a hydrogen atom,
R2, R3, and R4 are independently a hydrogen atom, a linear, branched, or cyclic C1-20 alkyl group, a C6-20 arylalkyl group,
wherein the alkyl group and the arylalkyl group are optionally substituted with an alkoxy group, a hydroxy group, an ammonium group, a carboxy group, or a cyano group, or —(CH2CH2O)m—R5,
wherein R5 is a hydrogen atom or a methyl group, and m is an arbitrary integer of 2 to 100, or
R2, R3, and R4 are optionally bonded to each other through a linear, branched, or cyclic alkylene group to form a ring together with a nitrogen atom to which R2, R3, and R4 are bonded,
wherein at least one of R2, R3, and R4 is an octyl group or a dodecyl group,
X? is an anion,
A1 is a structure of Formula (2):

wherein:
A2 is a linear, branched, or cyclic C1-30 alkylene group that optionally contains an ether bond or an ester bond, and
Y1, Y2, Y3, and Y4 are a hydrogen atom, and
n is the number of repeating unit structures that is an integer of 2 to 100,000, and
the complex has a higher catalyst activity compared to a same complex that does not have the branched polymer compound of Formula (1).

US Pat. No. 10,597,486

ENCAPSULANT COMPOSITION FOR USE WITH ELECTRICAL COMPONENTS IN HARD DISK DRIVES, AND RELATED ELECTRICAL COMPONENTS AND HARD DISK DRIVES

Seagate Technology LLC, ...

1. A method of coating one or more surfaces of at least a portion of an electrical structure for use in a hard disk drive, wherein the method comprises:a) applying an uncured encapsulant composition on at least a portion of a surface of the electrical structure, wherein the uncured encapsulant composition comprises:
i) uncured epoxy resin component; and
ii) an inorganic filler particle component, wherein the inorganic filler particle component is present in an amount of at least 0.05% by weight of the uncured encapsulant composition; and
b) curing the encapsulant composition, wherein the cured encapsulant composition has a Total Outgassing value of 1000 nanograms per gram or less of outgassed compounds of cured encapsulant composition according to Outgassing Test Procedure.

US Pat. No. 10,597,480

LAMINATE FILM

Hitachi Chemical Co., Ltd...

1. A laminate film comprising:a substrate film; and
a cured film that is a cured curable composition disposed on one surface or both surfaces of the substrate film, wherein
the substrate film is a film comprising a cyclic olefin resin; and
the curable resin composition comprises:
(A) an acrylic resin having a polymerizable double bond;
(B) a multifunctional polymerizable compound having three or more polymerizable double bonds, and having one or more monovalent groups represented by the following formula (2-1) or (2-2) as a group containing the polymerizable double bond; and
(C) an alkylene oxide modified bisphenol A di(meth)acrylate represented by the following formula (3),

wherein R1 represents a hydrogen atom or a methyl group, d represents an integer of 2 to 4, and e represents an integer of 1 to 6;

wherein R1 represents a hydrogen atom or a methyl group, m is 5, and n represents an integer of 1 to 4;

wherein R1 represents a hydrogen atom or a methyl group, f represents an integer of 2 to 5, g and h represent an integer of 1 or more, and g+h is 2 to 40;
a double bond equivalent of the multifunctional polymerizable compound is 130 or more and 500 or less when the double bond equivalent is defined by a formula: double bond equivalent=molecular weight/number of polymerizable double bonds in the same molecule;
the multifunctional polymerizable compound is a compound different from the acrylic resin;
the arithmetic average roughness of the surface of the cured film is 0.1 ?m or less; and
wherein the acrylic resin is present in a ratio of 8 parts by mass or more and 40 parts by mass or less; the multifunctional polymerizable compound in a ratio of 40 parts by mass or more and 80 parts by mass or less; and the alkylene oxide modified bisphenol A di(meth)acrylate in a ratio of 4 parts by mass or more and 40 parts by mass or less.

US Pat. No. 10,597,477

FINELY DIVIDED AQUEOUS EMULSION POLYMERS AND USE THEREOF FOR HYDROPHOBIC COATINGS

BASF SE, Ludwigshafen (D...

1. A polymer dispersion obtained by at least one, two-stage emulsion polymerization process comprising:1) performing a first radical polymerization of a first composition comprising:
A) at least one first monomer, and
B) at least one first anionic copolymerizable emulsifier, to obtain a polymer A;
2) admixing the polymer A with a base, to obtain a treated polymer A; and
3) in the presence of the treated polymer A, performing a second radical polymerization of a second composition comprising:
A) at least one second monomer, and
B) at least one second anionic copolymerizable emulsifier,to obtain a polymer B,wherein:
a weight-average molecular weight of the polymer A is between 5 and 25 kDa;
the at least one first monomer contained in the first composition is selected such that a glass transition temperature calculated for the polymer A ranges from 70° C. to 125° C.; and
the at least one first anionic copolymerizable emulsifier, the at least one second anionic copolymerizable emulsifier, or both, is selected from the group consisting of:
(1) a compound of formula (I):

where
R1 is H, alkyl, cycloalkyl, aralkyl, aryl, or alkoxyaryl,
R2, R2? is H, or R2 and R2? together represent ?O,
R3 is H or alkyl,
R4 is H or OH,
X is SO3?, HPO4?, PO42?, or COO?,
m is 0 or 1, and
n is an integer between 0 and 1000;
(2) a compound of formula (II):

where
X is SO3?, PO42?, or SO4?, and
R is H, alkyl, cycloalkyl, aralkyl, aryl or alkoxyaryl;
(3) a compound of formula (III):

where
R1 is H, alkyl, cycloalkyl, aralkyl, aryl or alkoxyaryl,
X is SO4?, SO3?, HPO4?, PO42?, or COO?, and
n is an integer between 0 and 1000; and
(4) a compound of the formula (IV):

where
R1 is H, alkyl, cycloalkyl, aralkyl, aryl, or alkoxyaryl,
Y is SO3?, PHO3?, or PO32?, and
n is an integer between 0 and 1000;
or mixtures of the compounds of the formulae (I) to (IV).

US Pat. No. 10,597,473

POLYMERIZATION PROCESS FOR PRODUCING ETHYLENE BASED POLYMERS

Dow Global Technologies L...

1. A polymerization process for producing ethylene based polymers comprising polymerizing ethylene and optionally one or more ?-olefins in the presence of one or more catalyst systems in a reactor system having one or more reactors, wherein at least one catalyst system comprises;(a) one or more procatalysts comprising a metal-ligand complex of formula (I) below:

wherein:
M is titanium, zirconium, or hafnium, each independently being in a formal oxidation state of +2, +3, or +4; and d is an integer of from 0 to 3, and wherein when d is 0, X is absent; and each X independently is a monodentate ligand that is neutral, monoanionic, or dianionic; or two Xs are taken together to form a bidentate ligand that is neutral, monoanionic, or dianionic; and X and d are chosen in such a way that the metal-ligand complex of formula (I) is, overall, neutral; and
each Z independently is O, S, N(C1-C40)hydrocarbyl, or P(C1-C40)hydrocarbyl; and
L is (C2-C40)hydrocarbylene or (C2-C40)heterohydrocarbylene, wherein the (C3-C40)hydrocarbylene has a portion that comprises a 2-carbon atom to 10-carbon atom linker backbone linking the Z atoms in formula (I) (to which L is bonded) and the (C2-C40)heterohydrocarbylene has a portion that comprises a 2-atom to 10-atom linker backbone linking the Z atoms in formula (I), wherein each of the 2 to 10 atoms of the 2-atom to 10-atom linker backbone of the (C2-C40)heterohydrocarbylene independently is a carbon atom or heteroatom, wherein each heteroatom independently is O, S, S(O), S(O)2, Si(RC)2, P(RP), or N(RN), wherein independently each RC is (C1-C30)hydrocarbyl, each RP is (C1-C30) hydrocarbyl; and each RN is (C1-C30)hydrocarbyl or absent; and
m is an integer from 1 to 6 and each o is an integer from 1 to 3;
each Y is independently selected from the group consisting of C, Si, Ge, N, C, S, P and combination thereof to form a cyclic structure containing from three to eight ring atoms and wherein n is an integer from 0 to 3;
each Rn is independently selected from the group consisting of hydrogen, unsubstituted or substituted (C1-C18)alkyl, aryl, heterohydrocarbyl, heteroaryl, ?O, FCH2O—, F2HCO—, F3CO—, RC3Si—, RCO—, RCS—, RC2N—, RC2C?N—, NC—, RCC(O)O—, RCOC(O)—, RCC(O)N(R)—, or RC2NC(O)—, or two of the RC are taken together to form a ring structure that can be unsubstituted or substituted with one or more RS substituents;
each T and each Q are independently selected from the group consisting of H, C, Si, Ge, N, O, S, and P and optionally can be linked to form cyclic structures containing from three to eight ring atoms;
R1-12 are each independently selected from the group consisting of a (C1-C40)hydrocarbyl, (C1-C40)heterohydrocarbyl, Si(RC)3, Ge(RC)3, P(RP)2, N(RN)2, ORC, SRC, NO2, CN, CF3, RCS(O)—, RCS(O)2—, (RC)2C?N—, RCC(O)O—, RCOC(O)—, RCC(O)N(R)—, (RC)2NC(O)—, halogen atom, hydrogen atom, and combination thereof; and,
wherein at least one of R1 and R12 has the structure of formula (II) below:

wherein each of R13 through R20 is independently selected from the group consisting of (C1-C40)hydrocarbyl, (C1-C40)heterohydrocarbyl, Si(RC)3, Ge(RC)3, P(RP)2, N(RN)2, ORC, SRC, NO2, CN, CF3, RCS(O)—, RCS(O)2—, (RC)2C?N—, RCC(O)O—, RCOC(O)—, RCC(O)N(R)—, (RC)2NC(O)—, halogen atom, hydrogen atom, and combination thereof; each of the hydrocarbyl, heterohydrocarbyl, Si(RC)3, Ge(RC)3, P(RP)2, N(RN)2, ORC, SRC, RCS(O)—, RCS(O)2—, (RC)2C?N —, RCC(O)O—, RCOC(O)—, RCC(O)N(R)—, (RC)2NC(O)—, hydrocarbylene, and heterohydrocarbylene groups independently is unsubstituted or substituted with one or more RS substituents, and
each RS independently is a halogen atom, polyfluoro substitution, perfluoro substitution, unsubstituted (C1-C18)alkyl, F3C—, FCH2O—, F2HCO—, F3CO—, R3Si—, R3Ge—, RO—, RS—, RS(O)—, RS(O)2—, R2P—, R2N—, R2C?N—, NC—, RC(O)O—, ROC(O)—, RC(O)N(R)—, or R2NC(O)—, or two of the RS are taken together to form an unsubstituted (C1-C18)alkylene, wherein each R independently is an unsubstituted (C1-C18)alkyl; and wherein two or more R groups selected from R7-12, R7-9, R7-8, R2-6, R3-6, R5-6 may combine together into ring structures, with such ring structures having from 3 to 50 atoms in the ring excluding any hydrogen atoms.

US Pat. No. 10,597,472

IN-LINE BLENDING PROCESS

BOREALIS AG, Vienna (AT)...

1. An in-line blending process for polymers comprising:(a) providing two or more reactor-low pressure separator units (1,7) in parallel configuration, each reactor-low pressure separator unit comprising one reactor (2,8) fluidly connected to one low pressure separator (3,9) downstream and further a recycling line (5,11) connecting the low pressure separator (3,9) back to the corresponding reactor (2,8);
(b) contacting in the two or more reactors (2,8) of each reactor-low pressure separator unit (1,7)
1) olefin monomers having two or more carbon atoms,
2) one or more catalyst systems,
3) optionally one or more comonomers,
4) optionally one or more chain transfer agents, and
5) optionally one or more diluents or solvents,
wherein the reactors (2,8) are operated under operating conditions which ensure that the reactor contents form a single homogeneous phase, the reactor contents comprising the olefin monomers, any comonomer present, any diluent or solvent present, any chain transfer agent present, and the polymer product;
whereby the catalyst system for each reactor comprises one or more catalyst precursors, one or more activators, and optionally, one or more catalyst supports;
(c) forming an unreduced reactor effluents stream including a homogeneous fluid phase polymer-monomer-solvent mixture in each of the reactors (2,8);
(d) passing the unreduced reactor effluents streams from each of the reactors (2,8) through the corresponding low pressure separators (3,9),
whereby the temperature and pressure of the low pressure separators (3,9) is adjusted such that a liquid phase and a vapour phase are obtained, thereby yielding a polymer-enriched liquid phase and a polymer-lean vapour phase;
(e) separating the polymer-lean vapour phase from the polymer-enriched liquid phase in each of the low-pressure separators (3,9) to form separated polymer-lean vapour streams and separated polymer-enriched liquid streams;
(f) combining the polymer-enriched liquid streams from step (e) in a further low-pressure separator and/or a mixer (13) to produce a combined polymer-enriched liquid stream (16);
(g) reintroducing the polymer-lean vapour streams from step (e) via recycling lines (5,11) into the corresponding reactors (2,8).

US Pat. No. 10,597,470

PROCESS FOR PRODUCING MULTIMODAL POLYETHYLENE BLENDS INCLUDING ULTRA-HIGH MOLECULAR WEIGHT COMPONENTS

BOREALIS AG, Vienna (AT)...

1. A process for producing a multimodal polyethylene composition comprising the following steps:i) blending a polyethylene fraction (A-1) having a viscosity average molecular weight My of equal to or more than 700 kg/mol to equal to or less than 10,000 kg/mol and a density of equal to or more than 920 kg/m3 to equal to or less than 960 kg/m3 and a polyethylene fraction (A-2) having a lower weight average molecular weight Mw than that of polyethylene fraction (A-1) of 50 to 500 kg/mol and a density of equal to or more than 910 kg/m3 to equal to or less than 960 kg/m3 with a weight ratio of (A-1) to (A-2) of 45:55 to 80:20 to form a first polyethylene resin (A) having a Mw of equal to or more than 200 kg/mol to equal to or less than 1500 kg/mol, a melt flow rate MFR5 (190° C., 5 kg) of 0.001 to 10 g/10 min and a density of equal to or more than 910 kg/m3 to equal to or less than 960 kg/m3,
ii) blending the first polyethylene resin (A) with a second polyethylene resin (B) having a Mw of equal to or more than 50 kg/mol to less than 700 kg/mol, and a density of equal to or more than 910 kg/m3 to equal to or less than 960 kg/m3 to form the multimodal polyethylene composition,
wherein a weight ratio of the first polyethylene resin (A) to the second polyethylene resin (B) in the multimodal polyethylene composition is 2:98 to 50:50, and
wherein the multimodal polyethylene composition has a melt flow rate MFR5 (190° C., 5 kg) of 0.01 to 10 g/10 min and a density of equal to or more than 910 kg/m3 to equal to or less than 970 kg/m3.

US Pat. No. 10,597,467

CROSS-LINKING AGENTS CONTAINING ISOCYANATE GROUPS FOR NITRILE RUBBERS

ARLANXEO DEUTSCHLAND GMBH...

1. Vulcanized molded articles produced by a process comprising cross-linking, with warming, a vulcanizable composition comprising:at least one hydroxyl group-containing (H)NBR rubber having a Mooney viscosity ML(1+4)100° C. of 15 to 160 Mooney units, and containing repeating units derived from at least one conjugated diene, at least one ?,?-unsaturated nitrile, and at least one copolymerizable hydroxyl group-containing monomer, wherein C?C double bonds in the case of the HNBR are completely or partially hydrogenated;
at least one compound of the general formula (I) as cross-linkers,

wherein
R1 is O—[M]p—R3 or NH—[M]p—R3
R2 is H
or R1 and R2 together yield a single bond or one of the following groups

R3, R4 and R5 are in each case identical or different and denote H or a radical that contains one or more of the following groups, a saturated, mono- or polyunsaturated carbo- or heterocyclyl radical, straight-chain or branched alkyl, aryl, heteroaryl, arylalkyl, heteroarylalkyl, alkoxy, aryloxy, heteroaryloxy, amino, amido, hydroxyimino, carbamoyl, alkoxycarbonyl, F, Cl, Br, I, hydroxyl, phosphonato, phosphinato, alkylthio, arylthio, thiocarboxy, sulphinyl, sulphono, sulphino, sulpheno, sulphonic acids, sulphamoyl, silyl, silyloxy, nitrile, sulphanyl, hydroperoxycarbonyl, hydroperoxy, thiocarboxy, dithiocarboxy, hydroxyimino, nitro, nitrosyl, carbonyl, carboxy, oxycarbonyl, oxysulphonyl, oxo, thioxo, borate, selenate, epoxy, cyanate, thiocyanate, isocyanate, thioisocyanate or isocyanide,
M represents repeating units of one or more mono- or polyunsaturated monomers, selected from the group consisting of conjugated or non-conjugated dienes, alkynes, vinyl compounds, and a divalent structural element, which is derived from polymers selected from the group consisting of polyethers, polyalkylene oxides, polysiloxanes, polyols, polycarbonates, polyurethanes, polyisocyanates, polysaccharides, polyesters and polyamides, and
p, q and r are identical or different and are 0 to 10,000;
the compounds of the general formula (I) in each case contain at least two isocyanate groups;
the composition contains either no solvents at all, or not more than 15% by weight solvents, based on the hydroxyl group-containing (H)NBR rubber, and the composition is not in liquid form; and
the composition comprises at least one mold-release agent.

US Pat. No. 10,597,441

HUMANIZED ANTIBODIES THAT RECOGNIZE ALPHA-SYNUCLEIN

PROTHENA BIOSCIENCES LIMI...

1. An antibody comprising a mature heavy chain variable region comprising the three Kabat CDRs of SEQ ID NO: 25, and being at least 90% identical to SEQ ID NO: 25, and a mature light chain variable region comprising the three Kabat CDRs of SEQ ID NO: 37, and being at least 90% identical to SEQ ID NO: 37.

US Pat. No. 10,597,436

ACYLATED INSULIN COMPOUND

Eli Lilly and Company, I...

1. A compound having the formula:

US Pat. No. 10,597,426

POLYPEPTIDE COMPOUND AND PREPARATION METHOD AND USE THEREOF

BEIJING COISLITONG INDUST...

1. A polypeptide compound, having a structural formula expressed as (XAXBXCXDXE-X)2KY, {(XAXBXCXDXE-X)2K}2KY or {({XAXBXCXDXE-X}2K)2K}2KY;wherein, XA is a polar amino acid molecule, XB and XE are alkaline amino acid molecules (the same or different), XC and XD are non-polar amino acid molecules (the same or different), K is lysine (Lys, K), and X and Y are null, or one or more of amino acid or chemical groups,
wherein the {(XAXBXCXDXE-X)2K}2KY structure is shown in formula 5:

US Pat. No. 10,597,423

6.ALPHA.-ALKYL-6,7-DIONE STEROIDS AS INTERMEDIATES FOR THE PRODUCTION OF STEROIDAL FXR MODULATORS

NZP UK Limited, Bristol ...

1. A process for the preparation of a compound of general formula (I):
wherein:
R1 is C1-4 alkyl optionally substituted with one or more substituents selected from halo, OR6 or NR6R7;
where each of R6 and R7 is independently selected from H or C1-4 alkyl;
R2 is H, halo or OH or a protected OH, which is stable under basic conditions;
Y1 is a bond or an alkylene linker group having from 1 to 20 carbon atoms and optionally substituted with one or more R3 groups;
each R3 is independently halo, OR8 or NR8R9;
where each of R8 and R9 is independently selected from H or C1-4 alkyl;
and
R4 is C(O)OR10, OC(O)R10, C(O)NR10R11, OR10, OSi(R13)3), S(O)R10, SO2R10, OSO2R10, SO3R10, or OSO3R10;
where each R10 and R11 is independently:
a. hydrogen or
b. C1-20 alkyl, C2-20 alkenyl, C2-20 alkynyl, —O—C1-20 alkyl, —O—C2-20 alkenyl or —O—C2-20 alkynyl, any of which is optionally substituted with one or more substituents selected from halo, NO2, CN, OR19, SR19, SO2R19, SO3R19 or N(R19)2, or a 6- to 14-membered aryl or 5 to 14-membered heteroaryl group, either of which is optionally substituted with C1-6 alkyl, C1-6 haloalkyl, halo, NO2, CN, OR19, SR19, SO2R19, SO3R19 or N(R19)2; or
c. a 6- to 14-membered aryl or 5 to 14-membered heteroaryl group optionally substituted with one or more substituents selected from C1-6 alkyl, C1-6 haloalkyl, halo, NO2, CN, OR19, SR19, SO2R19, SO3R19 or N(R19)2;
d. a polyethylene glycol residue;
each R19 is independently selected from H, C1-6 alkyl, C1-6 haloalkyl, or a 6- to 14-membered aryl or 5 to 14-membered heteroaryl group optionally substituted with halo, C1-6 alkyl or C1-6 haloalkyl;
each R13 is independently
a. C1-20 alkyl, C2-20 alkenyl or C2-20 alkynyl optionally substituted with one or more substituents selected from halo, NO2, CN, OR19, SR19, SO2R19, SO3R19 or N(R19)2, a 6- to 14-membered aryl or 5 to 14-membered heteroaryl group, either of which is optionally substituted with C1-6 alkyl, C1-6 haloalkyl, halo, NO2, CN, OR19, SO2R19, SO3R19 or N(R19)2; or
b. a 6- to 14-membered aryl or 5 to 14-membered heteroaryl group optionally substituted with one or more substituents selected from C1-6 alkyl, C1-6 haloalkyl, halo, NO2, CN, OR19, SR19, SO2R19, SO3R19 or N(R19)2;
each R19 is independently selected from H, C1-6 alkyl or C1-6 haloalkyl;
R5b is H or OH or a protected OH;
or a salt thereof
comprising:
A. epimerization of a compound of general formula (II):

wherein Y1, R1, R2, and R4 are of general formula (I) and R5 is H or OH or a protected OH;
by treatment with a base; or
B. conversion of a compound of general formula (I) in which R4 is C(O)OR10 to another compound of general formula (I) by a process comprising:
i. for a compound of general formula (I) in which R4 is OSO3R10:
reacting a compound of general formula (I) in which R4 is C(O)OR10 with a reducing agent followed by reaction with chlorosulfuric acid in the presence of a base;
ii. for a compound of general formula (I) in which R4 is OSO2R10:
reacting a compound of general formula (I) in which R4 is C(O)OR10 with a reducing agent followed by reaction with chlorosulfurous acid;
iii. for a compound of general formula (I) in which R4 is C(O)NR10R11:
reacting a compound of general formula (I) in which R4 is C(O)OH with an amine of formula H—NR10R11.

US Pat. No. 10,597,422

PROCESS FOR MAKING CHLORO-SUBSTITUTED NUCLEOSIDE PHOSPHORAMIDATE COMPOUNDS

1. A compound having the formula:
X is selected from C1-C6 alkylene, C6-C10 arylene, C4-C10 cycloalkylene, 5 or 6-membered monocyclic heteroarylene and 9 or 10-membered bicyclic heteroarylene, wherein said C6-C10 arylene group, said C4-C10 cycloalkylene group, said 5 or 6-membered monocyclic heteroarylene group and said 9 or 10-membered bicyclic heteroarylene group can be optionally substituted with one or more R5 groups;
each occurrence of R5 is independently selected from —C1-C6 alkyl, halo, —OR6, —C(O)R6, —CO2R6, —SR6, —C1-C6 hydroxyalkyl, —C1-C6 haloalkyl, —N(R6)2, —S(O)R6, —S(O)2R6, —CN and —NO2;
each occurrence of R6 is independently selected from H, C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 hydroxyalkyl, —(C1-C3 alkylene)m-(C3-C7 cycloalkyl), —(C1-C3 alkylene)m-(C6-C10 aryl), —(C1-C3 alkylene)m-(4 to 7-membered heterocycloalkyl), —(C1-C3 alkylene)m-(5- or 6-membered monocyclic heteroaryl) and —(C1-C3 alkylene)m-(9- or 10-membered bicyclic heteroaryl);
each occurrence of R7 is independently selected from H, C1-C6 alkyl, phenyl, C3-C7 cycloalkyl, 4 to 7-membered monocyclic heterocycloalkyl and 5- or 6-membered monocyclic heteroaryl;
each occurrence of R8 is independently selected from H, C1-C6 alkyl, phenyl, C3-C7 cycloalkyl, 4 to 7-membered monocyclic heterocycloalkyl and 5- or 6-membered monocyclic heteroaryl;
each occurrence of m is independently 0 or 1;
p is 2, 3, 4 or 5; and
q is 2, 3, 4 or 5.

US Pat. No. 10,597,417

PROCESSES FOR THE PREPARATION OF GALNAC ACID DERIVATIVES

Hoffmann-La Roche Inc., ...

1. A process for the preparation of a GalNAc acid derivative of the formula I:
or a salt, enantiomer or optical isomer thereof, wherein n is an integer between 0 and 10, comprising the steps:
a) reacting a triamine salt of formula II:

wherein R1 is an ester protecting group and X is an anion of an acid, with a tetrahydropyran acid of formula III:

wherein R2 is a hydroxy protecting group and n is as defined above,
in the presence of a peptide coupling agent, an amine base and an organic solvent, to form a GalNAc ester of formula IV:

wherein R1, R2 and n are as defined above;
b) removing the ester protecting group R1 and the hydroxy protecting groups R2 in the presence of a mineral base to form a GalNAc acid salt of formula V:

wherein n is as defined above and M is a metal cation;
and
c) optionally transforming the GalNAc acid salt of formula V into the GalNAc acid derivative of formula I.

US Pat. No. 10,597,416

COMPLEXES

Johnson Matthey PLC, Lon...

1. A complex of formula (1):wherein:M is palladium or nickel,
R1 and R2 are, independently, C1-20 straight-chain alkyl, C1-20 branched-chain alkyl, or C3-15 cycloalkyl,
R3 is a) or b):
a) substituted aryl, wherein the aryl is substituted with one or more halide, C2-20 alkoxy, substituted C6-20 aryl, branched-chain (C1-20 dialkyl)amino, C2-15 heterocycloalkyl, or tri(halo)methyl; or
b) substituted or unsubstituted heteroaryl that is thienyl, furanyl, pyrrolyl, imidazolyl, pyrazolyl, thiazolyl, isothiazolyl, oxazolyl, isoxazolyl, triazolyl, thiadiazolyl, thiophenyl, oxadiazolyl, pyridinyl, pyrimidyl, benzoxazolyl, benzthiazolyl, benzimidazolyl, indolyl, or quinolinyl;
R4 is C1-20 straight-chain alkyl, C1-20 branched-chain alkyl, C3-15 cycloalkyl, C6-20 aryl, or C5 -20 heteroaryl;
n is 0, 1, 2, 3, 4 or 5,
X is halo;
wherein each alkyl, alkoxy, heteroalkyl, aryl or heteroaryl is optionally substituted with one or more halo, C(halo)3, Ra, ?O, ?S, ORa, SRa, NRaRb, ?NRa, ?N—ORa, CN, SCN, NCS, NO2, C(O)Ra, C(O)ORa, C(S)Ra, C(S)ORa, S(O)2OH, S(O)2Ra, S(O)2NRaRb, OS(O)Ra, or C(O)NRaRb, wherein:
Ra and Rb are, independently, H, C1-20 alkyl, C6-20 aryl, C6-20 aryl-(C1-20alkyl), C1-20 heteroalkyl, or C6-20 heteroaryl, or together with the atom to which they are attached form a C3-15 heterocycloalkyl; and the heteroatoms in the heteroaryl, heteroalkyl or heterocycloalkyl are sulfur, oxygen, or nitrogen.

US Pat. No. 10,597,415

PENTAAZA MACROCYCLIC RING COMPLEXES POSSESSING ORAL BIOAVAILABILITY

GALERA LABS, LLC, Creve ...

1. A method of lessening the severity of tissue damage resulting from a cancer treatment in a mammal afflicted with cancer, comprising orally administering a therapeutically effective dose of a pentaaza macrocyclic ring complex to the mammal,wherein the pentaaza macrocyclic ring complex comprises the following formula:

US Pat. No. 10,597,411

COMPOSITIONS AND METHODS FOR INHIBITING ARGINASE ACTIVITY

Calithera Biosciences, In...

1. A method of treating cancer, comprising administering to a patient in need thereof a therapeutically effective amount of a compound of formula (I*):or a pharmaceutically acceptable salt thereof,wherein:
R1 is methyl; and
R4 is H or (C1-C6)alkyl.

US Pat. No. 10,597,409

WATER-SOLUBLE TRIAZAPYRIDINOPHANE-BASED COMPLEXING AGENTS AND CORRESPONDING FLUORESCENT LANTHANIDE COMPLEXES

CISBIO BIOASSAYS, Codole...

1. A complexing agent of formula (I):
wherein:
the R1 groups are identical and are either: —CO2H, or —PO(OH)R, wherein R is selected from the group consisting of: phenyl optionally substituted by an —SO3H group benzyl, methyl, ethyl, propyl, n-butyl, sec-butyl, isobutyl, and tent-butyl;
the A1, A2 groups are identical or different and are selected from the group consisting of: a group of formula -L1-E; a group of formula (II) and a group of formula (II?);
the A3 group is selected from the group consisting of: a group of formula —O-L3-G, a group of formula (II), a group of formula (II?), a group of formula (III), and a group of formula (III?);

L1, L2 and L3 are identical or different and each represent a divalent linkage group;
E is a group that renders the complexing agent water-soluble, chosen selected from the group consisting of: —SO3H, —PO(OH)2, —CO2H, —N+Alk1Alk2Alk3, a carbohydrate residue, a sulfobetaine; and a PEG group;
G is a reactive group selected from the group consisting of: an acrylamide, an amine, an ester, an aldehyde, an alkyl halide, an anhydride, an aniline, an azide, an aziridine, a carboxylic acid, a diazoalkane, a haloacetamide, a halotriazine, dichlorotriazine, a hydrazine, an imido ester, an isocyanate, an isothiocyanate, a maleimide, a sulfonyl halide, a thiol, a ketone, an acid halide, a succinimidyl ester, a hydroxysuccinimidyl ester, a hydroxysulfosuccinimidyl ester, an azidonitrophenyl, an azidophenyl, a glyoxal, a triazine, and an acetylenic group;
Alk1, Alk2, Alk3, which may be identical or different, each represent a (C1-C6)alkyl.

US Pat. No. 10,597,407

ENERGY STORAGE MOLECULAR MATERIAL, CRYSTAL DIELECTRIC LAYER AND CAPACITOR

CAPACITOR SCIENCES INCORP...

1. An energy storage molecular material having a general molecular structural formula:
wherein Cor is a predominantly planar polycyclic molecular system which forms column-dike supramolecular stacks by means of ?-?-interaction, wherein the planar polycyclic molecular system comprises planar fused polycyclic hydrocarbons selected from the group of truxene, decacyclene, antanthrene, hexabenzotriphenylene, 1,2,3,4,5,6,7,8-tetra-(peri-naphthylene)-anthracene, dibenzoctacene, tetrabenzoheptacene, peropyrene, hexabenzocoronene and has a general structural formula 7-17:

P is a polarization unit, wherein the polarization unit is comprised of rylene fragments of a general structure selected from the group of structures 33-53:

I is a high-breakdown insulating substituent group,
n is 1, 2, 3, 4, 5, 6, 7 or 8,
m is 1, 2, 3, 4, 5, 6, 7 or 8, and
wherein the high-breakdown insulating substituent group is independently selected from the group consisting of —(CH2)n—CH3, and —CH((CH2)nCH3)2) where n is any number between 1 and 50, alkyl, aryl, substituted alkyl, substituted aryl, branched alkyl, branched aryl, and any combination thereof and wherein the alkyl group is selected from the group of methyl, ethyl, propyl, butyl, I-butyl and t-butyl groups, and the aryl group is selected from the group of phenyl, benzyl and naphthyl groups.

US Pat. No. 10,597,405

CHEMICAL COMPOUNDS

1. A compound of Formula (I):wherein:A is selected from C6-C10 aryl, monocyclic heteroaryl and bicyclic heteroaryl;
R1 is in each instance independently selected from F, Cl, Br, OH, CN, C1-C4 alkyl, C1-C4 alkoxy, C1-C3 fluoroalkyl, C1-C3 fluoroalkoxy, acetylenyl, NR9R10, C(O)NR11R12, CH2R13 and N?S(O)Me2;
b is 0, 1, 2 or 3;
W is CR14 or N;
X is CR15 or N;
Y is CH or N;
Z is O or NR16;
R2 is H, CN, F, Cl, Br, C1-C4 alkyl, C1-C4 alkoxy, C1-C3 fluoroalkyl, C1-C2 fluoroalkoxy or acetylenyl;
R3a and R3b are each independently selected from H or Me or, in the case where Z is NR16, can also together be ?O;
R4, R5, R6 and R7 are each independently selected from H or Me;
R8 is H or CH2NMe2;
R9 is H, C1-C4 alkyl, C(O)C1-C3 alkyl or CO2C1-C3 alkyl;
R10, R11 and R12 are each independently selected from H and C1-C4 alkyl; or
R9 and R10 together, or R11 and R12 together, form a 4-, 5-, 6- or 7-membered saturated heterocycle optionally incorporating O, NH or N(C1-C4 alkyl) group;
R13 is OH, CN, NR17R18, C(O)NR19R20 or SO2C1-C3alkyl;
R14 and R15 are each independently selected from H, F, Cl, MeO and Me;
R16 is H, C1-C3 fluoroalkyl or CH2R21;
R17, R18, R19 and R20 are each independently selected from H and C1-C4 alkyl or R17 and R18 together, or R19 and R20 together, form a 4-, 5-, 6- or 7-membered saturated heterocycle optionally incorporating O, NH or N(C1-C4 alkyl) group;
R21 is selected from the group consisting of:
H;
C1-C3 alkyl optionally substituted with 1 or 2 substituents selected from hydroxy, C1-C3 alkoxy, halo, NR22R23, C(O)NR24R25, SO2Me, heteroaryl, C3-7cycloalkyl or heterocyclyl, wherein said heteroaryl or C3-C7cycloalkyl is optionally further substituted with C1-C4 alkyl, hydroxy, halo, cyano, or C1-C4 alkoxy and said heterocyclyl is optionally further substituted with C1-C4 alkyl, hydroxy, halo, C(O)Me, C1-C3 alkoxy, C1-C3fluoroalkyl, C3-C7cycloalkyl, heterocyclyl or heteroaryl and wherein R22, R23, R24 and R25 are in each instance independently selected from H and C1-C4 alkyl;
C3-C7cycloalkyl optionally substituted with C1-C4 alkyl, hydroxy or halo;
heterocyclyl optionally substituted with C1-C4 alkyl, hydroxy, halo, C(O)Me, C1-C3 alkoxy, C1-C3 fluoroalkyl, C3-C7 cycloalkyl, CH2cyclopropyl, heterocyclyl or heteroaryl; and
heteroaryl optionally substituted with C1-C4 alkyl, hydroxy, halo, cyano or C1-C4 alkoxy;or a pharmaceutically acceptable salt thereof.

US Pat. No. 10,597,403

CONDENSED CYCLIC COMPOUND, COMPOSITION INCLUDING THE CONDENSED CYCLIC COMPOUND, ORGANIC LIGHT-EMITTING DEVICE INCLUDING THE CONDENSED CYCLIC COMPOUND, AND METHOD OF MANUFACTURING THE ORGANIC LIGHT-EMITTING DEVICE

SAMSUNG ELECTRONICS CO., ...

1. A condensed cyclic compound represented by Formula (1):
wherein, in Formula (1),
L1 to L3 are each independently selected from a single bond, a substituted or unsubstituted C2-C60 alkylene group, a substituted or unsubstituted C3-C10 cycloalkylene group, a substituted or unsubstituted C1-C10 heterocycloalkylene group, a substituted or unsubstituted C3-C10 cycloalkenylene group, a substituted or unsubstituted C1-C10 heterocycloalkenylene group, a substituted or unsubstituted C6-C60 arylene group, a substituted or unsubstituted C1-C60 heteroarylene group, a substituted or unsubstituted divalent non-aromatic condensed polycyclic group, and a substituted or unsubstituted divalent non-aromatic condensed heteropolycyclic group,
L5 is selected from:
a single bond, *—C(?O)—*?, *—C(?S)—*?, and *—N(R5)—*?; and
a phenylene group, an indenylene group, a naphthylene group, an acenaphthylene group, a fluorenylene group, a spiro-bifluorenylene group, a phenanthrenylene group, an anthracenylene group, a fluoranthrenylene group, a triphenylenylene group, a pyrenylene group, a chrysenylene group, a pyrrolylene group, an imidazolylene group, a pyrazolylene group, a triazolylene group, a pyridinylene group, a pyrazinylene group, a pyrimidinylene group, a pyridazinylene group, a triazinylene group, a furanylene group, a thienylene group, an oxazolylene group, an isoxazolylene group, a thiazolylene group, an isothiazolylene group, an oxadiazolylene group, an isoxadiazolylene group, a thiadiazolylene group, an isothiadiazolylene group, a pyrenylene group, an indazolylene group, a purinylene group, a quinolinylene group, an isoquinolinylene group, a benzoquinolinylene group, a phthalazinylene group, a naphthyridinylene group, a quinoxalinylene group, a quinazolinylene group, a cinnolinylene group, a phenanthridinylene group, an acridinylene group, a phenanthrolinylene group, a phenazinylene group, a benzoxazolylene group, a benzothiazolylene group, a benzimidazolylene group, an isoindolylene group, an indolylene group, a benzofuranylene group, a benzothiophenylene group, a benzocarbazolylene group, a naphthobenzofuranylene group, a naphthobenzothiophenylene group, an imidazopyrimidinylene group, and an imidazopyridinylene group, each unsubstituted or substituted with at least one selected from deuterium, —F, -CD3, -CD2H, -CDH2, —CF3, —CF2H, —CFH2, —NCS, a cyano group, a C1-C20 alkyl group, a C1-C20 alkoxy group, a phenyl group, a pyridinyl group, a pyrimidinyl group, a triazinyl group, a biphenyl group, a phenylpyridinyl group, a phenylpyrimidinyl group, a phenyltriazinyl group, a diphenylpyridinyl group, a diphenylpyrimidinyl group, a diphenyltriazinyl group, a pyridinylphenyl group, a dipyridinylphenyl group, a pyrimidinylphenyl group, a dipyrimidinylphenyl group, a triazinylphenyl group, a ditriazinylphenyl group, a fluorenyl group, a spiro-bifluorenyl group, a dimethylfluorenyl group, a diphenylfluorenyl group, a carbazolyl group, a phenylcarbazolyl group, a biphenylcarbazolyl group, a dibenzofuranyl group, a phenyldibenzofuranyl group, a diphenyldibenzofuranyl group, a dibenzothiophenyl group, a phenyldibenzothiophenyl group, a diphenyldibenzothiophenyl group,
—Si(Q31)(Q32)(Q33), —N(Q31)(Q32), and —C(?O)(Q31), and* and *? each indicate a binding site to a neighboring atom,
a1 to a3 and a5 are each independently an integer selected from 1 to 10,
(L5)a5 is an n-valent linking group or a single bond, wherein n is a natural number greater than or equal to one,
when n is one, (L5)a5 does not exist,
when n is a natural number greater than or equal to two, at least one of *-(L1)a1-(A1), *-(L2)a2-(A2), and *-(L3)a3-(A3) is linked to (L5)a5 or is a single bond linked to (L5)a5,
i) A1 to A3 and R5 are each independently linked to (L5)a5;
ii) A1 to A3 and R5 are each independently a single bond linked to (L5)a5;
iii) A1 to A3 and R5 are each independently a group represented by one of Formulae (2) to (5); or
iv) A1 to A3 and R5 are each independently selected from a phenyl group, an indenyl group, a naphthyl group, an acenaphthyl group, a fluorenyl group, a spiro-bifluorenyl group, a phenanthrenyl group, an anthracenyl group, a fluoranthenyl group, a triphenylenyl group, a pyrenyl group, a chrysenyl group, a pyrrolyl group, a furanyl group, a thienyl group, an isoindolyl group, an indolyl group, a benzofuranyl group, a benzothiophenyl group, a benzocarbazolyl group, a naphthobenzofuranyl group, and a naphthobenzothiophenyl group, each unsubstituted or substituted with at least one selected from deuterium, -CD3, -CD2H, -CDH2, a C1-C20 alkyl group, a C1-C20 alkoxy group, a phenyl group, a biphenyl group, a fluorenyl group, a spiro-bifluorenyl group, a dimethylfluorenyl group, a diphenylfluorenyl group,

a group represented by *-(L2)a2-(A2) is linked to a third or fourth carbon of a carbazole core of Formula (1), a group represented by *-(L3)a3-(A3) is linked to a fifth or sixth carbon of the carbazole core of Formula (1), and * in the group represented by *-(L2)a2-(A2) and the group represented by *-(L3)a3-(A3) indicates a binding site to a carbon atom of the carbazole core of Formula (1), and
provided that, A2 is a group represented by one of Formulae (2) to (5) and A3 is not a group represented by one of Formulae (3) and (4):

wherein, in Formulae (2) to (5),
X1 is N, carbon linked to *-(L11)a11-(R11), or carbon linked to L13, X2 is N, carbon linked to *-(L11)a11-(R11), or carbon linked to L13, X3 is N, carbon linked to *-(L11)a11-(R11), or carbon linked to L13, X4 is N, carbon linked to *-(L11)a11-(R11), or carbon linked to L13, X5 is N, carbon linked to *-(L11)a11-(R11), or carbon linked to L13, X6 is N, carbon linked to *-(L11)a11-(R11), or carbon linked to L13, provided that X1 to X4 in Formula (4) are not carbon linked to L13,
Y1 is O, S, N(R13), or C(R14)(R15), and R14 and R15 are optionally linked to form a saturated or unsaturated ring,
CY1 is a C5-C30 carbocyclic group or a C2-C30 heterocyclic group,
at least one of X1 to X6 in Formula (2) is N,
in Formulae (3) and (4), at least one of X1 to X4 is N, or CY1 is a ? electron-depleted nitrogen-containing C2-C30 heterocyclic group,
at least one of X1 to X4 in Formula (5) is N,
L11 to L13 are each independently selected from a single bond, a substituted or unsubstituted C1-C60 alkylene group, a substituted or unsubstituted C3-C10 cycloalkylene group, a substituted or unsubstituted C1-C10 heterocycloalkylene group, a substituted or unsubstituted C3-C10 cycloalkenylene group, a substituted or unsubstituted C1-C10 heterocycloalkenylene group, a substituted or unsubstituted C6-C60 arylene group, a substituted or unsubstituted C1-C60 heteroarylene group, a substituted or unsubstituted divalent non-aromatic condensed polycyclic group, and a substituted or unsubstituted divalent non-aromatic condensed heteropolycyclic group,
a11 to a13 are each independently an integer selected from 1 to 10,
R11 to R15 are each independently selected from hydrogen, deuterium, —F, —Cl, —Br, —I, -CD3, -CD2H, -CDH2, —CF3, —CF2H, —CFH2, —NCS, a hydroxyl group, a cyano group, a nitro group, an amino group, an amidino group, a hydrazine group, a hydrazone group, a carboxylic acid group or a salt thereof, a sulfonic acid group or a salt thereof, a phosphoric acid group or a salt thereof, a substituted or unsubstituted C1-C60 alkyl group, a substituted or unsubstituted C2-C60 alkenyl group, a substituted or unsubstituted C2-C60 alkynyl group, a substituted or unsubstituted C1-C60 alkoxy group, a substituted or unsubstituted C3-C10 cycloalkyl group, a substituted or unsubstituted C1-C10 heterocycloalkyl group, a substituted or unsubstituted C3-C10 cycloalkenyl group, a substituted or unsubstituted C1-C10 heterocycloalkenyl group, a substituted or unsubstituted C6-C60 aryl group, a substituted or unsubstituted C6-C60 aryloxy group, a substituted or unsubstituted C6-C60 arylthio group, a substituted or unsubstituted C1-C60 heteroaryl group, a substituted or unsubstituted monovalent non-aromatic condensed polycyclic group, a substituted or unsubstituted monovalent non-aromatic condensed heteropolycyclic group, —Si(Q1)(Q2)(Q3), —N(Q1)(Q2), and —C(?O)(Q1), provided that R11 in Formula (2) is selected from a substituted or unsubstituted C3-C10 cycloalkyl group, a substituted or unsubstituted C1-C10 heterocycloalkyl group, a substituted or unsubstituted C3-C10 cycloalkenyl group, a substituted or unsubstituted C1-C10 heterocycloalkenyl group, a substituted or unsubstituted C6-C60 aryl group, a substituted or unsubstituted C6-C60 aryloxy group, a substituted or unsubstituted C6-C60 arylthio group, a substituted or unsubstituted C1-C60 heteroaryl group, a substituted or unsubstituted monovalent non-aromatic condensed polycyclic group, and a substituted or unsubstituted monovalent non-aromatic condensed heteropolycyclic group,
b2 is an integer from 0 to 2,
b3 is an integer from 0 to 3,
b4 is an integer from 01 to 4,
indicates a binding site to a neighboring atom, and
wherein the group represented by *-(L2)a2-(A2) and the group represented by *-(L3)a3-(A3) are linked to the carbazole core, such that a linking position of the group represented by *-(L2)a2-(A2) and the carbazole core is asymmetric to a linking position of the group represented by *-(L3)a3-(A3) and the carbazole core with respect to a reverse central axis passing through a nitrogen atom of the carbazole core of Formula (1), and
at least one substituent of the substituted C2-C60 alkylene group, the substituted C3-C10 cycloalkylene group, the substituted C1-C10 heterocycloalkylene group, the substituted C3-C10 cycloalkenylene group, the substituted C1-C10 heterocycloalkenylene group, the substituted C6-C60 arylene group, the substituted C1-C60 heteroarylene group, the substituted divalent non-aromatic condensed polycyclic group, the substituted divalent non-aromatic condensed heteropolycyclic group, the substituted C1-C60 alkyl group, the substituted C2-C60 alkenyl group, the substituted C2-C60 alkynyl group, the substituted C1-C60 alkoxy group, the substituted C3-C10 cycloalkyl group, the substituted C1-C10 heterocycloalkyl group, the substituted C3-C10 cycloalkenyl group, the substituted C1-C10 heterocycloalkenyl group, the substituted C6-C60 aryl group, the substituted C6-C60 aryloxy group, the substituted C6-C60 arylthio group, the substituted C1-C60 heteroaryl group, the substituted monovalent non-aromatic condensed polycyclic group, and the substituted monovalent non-aromatic condensed heteropolycyclic group in Formulae (1) to (5) is selected from:
deuterium, —F, —Cl, —Br, —I, -CD3, -CD2H, -CDH2, —CF3, —CF2H, —CFH2, —NCS, a hydroxyl group, a cyano group, a nitro group, an amino group, an amidino group, a hydrazine group, a hydrazone group, a carboxylic acid group or a salt thereof, a sulfonic acid group or a salt thereof, a phosphoric acid group or a salt thereof, a C1-C60 alkyl group, a C2-C60 alkenyl group, a C2-C60 alkynyl group, and a C1-C60 alkoxy group;
a C1-C60 alkyl group, a C2-C60 alkenyl group, a C2-C60 alkynyl group, and a C1-C60 alkoxy group, each substituted with at least one selected from deuterium, —F, —Cl, —Br, —I, -CD3, -CD2H, -CDH2, —CF3, —CF2H, —CFH2, —NCS, a hydroxyl group, a cyano group, a nitro group, an amino group, an amidino group, a hydrazine group, a hydrazone group, a carboxylic acid group or a salt thereof, a sulfonic acid group or a salt thereof, a phosphoric acid group or a salt thereof, a C3-C10 cycloalkyl group, a C1-C10 heterocycloalkyl group, a C3-C10 cycloalkenyl group, a C1-C10 heterocycloalkenyl group, a C6-C60 aryl group, a C6-C60 aryloxy group, a C6-C60 arylthio group, a C1-C60 heteroaryl group, a monovalent non-aromatic condensed polycyclic group, a monovalent non-aromatic condensed heteropolycyclic group, —Si(Q11)(Q12)(Q13), —N(Q11)(Q12), and —C(?O)(Q11);
a C3-C10 cycloalkyl group, a C1-C10 heterocycloalkyl group, a C3-C10 cycloalkenyl group, a C1-C10 heterocycloalkenyl group, a C6-C60 aryl group, a C6-C60 aryloxy group, a C6-C60 arylthio group, a C1-C60 heteroaryl group, a monovalent non-aromatic condensed polycyclic group, and a monovalent non-aromatic condensed heteropolycyclic group;
a C3-C10 cycloalkyl group, a C1-C10 heterocycloalkyl group, a C3-C10 cycloalkenyl group, a C1-C10 heterocycloalkenyl group, a C6-C60 aryl group, a C6-C60 aryloxy group, a C6-C60 arylthio group, a C1-C60 heteroaryl group, a monovalent non-aromatic condensed polycyclic group, and a monovalent non-aromatic condensed heteropolycyclic group, each substituted with at least one selected from deuterium, —F, —Cl, —Br, —I, -CD3, -CD2H, -CDH2, —CF3, —CF2H, —CFH2, a hydroxyl group, a cyano group, a nitro group, an amino group, an amidino group, a hydrazine group, a hydrazone group, a carboxylic acid group or a salt thereof, a sulfonic acid group or a salt thereof, a phosphoric acid group or a salt thereof, a C1-C60 alkyl group, a C2-C60 alkenyl group, a C2-C60 alkynyl group, a C1-C60 alkoxy group, a C3-C10 cycloalkyl group, a C1-C10 heterocycloalkyl group, a C3-C10 cycloalkenyl group, a C1-C10 heterocycloalkenyl group, a C6-C60 aryl group, a C6-C60 aryloxy group, a C6-C60 arylthio group, a C1-C60 heteroaryl group, a monovalent non-aromatic condensed polycyclic group, a monovalent non-aromatic condensed heteropolycyclic group, —Si(Q21)(Q22)(Q23), —N(Q21)(Q22), and —C(?O)(Q21); and
—Si(Q31)(Q32)(Q33), —N(Q31)(Q32), and —C(?O)(Q31),
wherein Q1 to Q3, Q11 to Q13, Q21 to Q23, and Q31 to Q33 are each independently selected from hydrogen, deuterium, a C1-C20 alkyl group, a C1-C20 alkoxy group, a phenyl group, a pyridinyl group, a pyrimidinyl group, a triazinyl group, a biphenyl group, a phenylpyridinyl group, a phenylpyrimidinyl group, a phenyltriazinyl group, a diphenylpyridinyl group, a diphenylpyrimidinyl group, a diphenyltriazinyl group, a pyridinylphenyl group, a dipyridinylphenyl group, a pyrimidinylphenyl group, a dipyrimidinylphenyl group, a triazinylphenyl group, a ditriazinylphenyl group, a fluorenyl group, a spiro-bifluorenyl group, a dimethylfluorenyl group, a diphenylfluorenyl group, a carbazolyl group, a phenylcarbazolyl group, a biphenylcarbazolyl group, a dibenzofuranyl group, a phenyldibenzofuranyl group, a diphenyldibenzofuranyl group, a dibenzothiophenyl group, a phenyldibenzothiophenyl group, and a diphenyldibenzothiophenyl group.

US Pat. No. 10,597,401

METHODS AND INTERMEDIATES FOR THE PREPARATION OF OMACETAXINE AND CEPHALOTAXINE DERIVATIVES THEREOF

Albany Molecular Research...

1. A process for preparation of a product compound of formula XIV:whereinR1 and R2 are each independently selected from the group consisting of hydrogen, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C7 cycloalkyl, C4-C7 cycloalkylalkyl, heterocycle, aryl, and heteroaryl, wherein each of C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C7 cycloalkyl, C4-C7 cycloalkylalkyl, heterocycle, aryl, and heteroaryl is optionally substituted from 1 to 3 times with substituents as defined below in R11; or
R1 and R2 are taken together to form a 5- to 7-membered ring having 0-2 heteroatoms independently selected from the group consisting of nitrogen, oxygen, and sulfur, optionally substituted from 1 to 3 times with R11; or
R1 and R2 are taken together with the atom to which they are attached to form a carbonyl, thiocarbonyl, sulfoxide, or sulfone;
R3 is hydrogen, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C7 cycloalkyl, C4-C7 cycloalkylalkyl, —CO2R9, —CON(R9)2, —COSR9, —COR9, —C(OH)(R9)2, —C(OR10)(R9)2, —C(NR102)(R9)2, heterocycle, aryl, or heteroaryl, wherein each of C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C7 cycloalkyl, C4-C7 cycloalkylalkyl, heterocycle, aryl, and heteroaryl is optionally substituted from 1 to 3 times with R11;
R4 is hydrogen, —N(R10)2, —OR10, —SR10, acyl, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C7 cycloalkyl, C4-C7 cycloalkylalkyl, —CO2R9, —CON(R9)2, —COSR9, —COR9, —C(OH)(R9)2, —C(OR10)(R9)2, —C(NR102)(R9)2, heterocycle, aryl, or heteroaryl, wherein each of C1-C6 alkyl, C2-C6 alkenyl, alkynyl, C3-C7 cycloalkyl, C4-C7 cycloalkylalkyl, heterocycle, aryl, and heteroaryl is optionally substituted from 1 to 3 times with R11; or
R3 and R4 are taken together to form a 5- to 7-membered ring having 0-2 heteroatoms independently selected from the group consisting of nitrogen, oxygen, and sulfur, optionally substituted from 1 to 3 times with R11;
R5 is hydrogen, —OR10, or ?O;
R6 is hydrogen, —OR10, —OCO2R10, —OCOR10, or —OCON(R10)2;
R7 and R8 are each independently selected from the group consisting of hydrogen, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C7 cycloalkyl, C4-C7 cycloalkylalkyl, heterocycle, aryl, heteroaryl, —SO2R10, and —CO2R10; or
R7 and R8 are taken together to form an optionally substituted 5- to 7-membered ring having 0-2 heteroatoms independently selected from nitrogen, oxygen, and sulfur;
R9 is hydrogen, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C7 cycloalkyl, C4-C7 cycloalkylalkyl, heterocycle, aryl, or heteroaryl, wherein each of C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C7 cycloalkyl, C4-C7 cycloalkylalkyl, heterocycle, aryl, and heteroaryl is optionally substituted from 1 to 3 times with R11;
each R10 is independently selected from the group consisting of hydrogen, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C7 cycloalkyl, C4-C7 cycloalkylalkyl, heterocycle, aryl, and heteroaryl, wherein each of C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C7 cycloalkyl, C4-C7 cycloalkylalkyl, heterocycle, aryl, and heteroaryl is optionally substituted from 1 to 3 times with R11; or two R10 on the same nitrogen are taken with the nitrogen to which they are attached to form a 4- to 7-membered heterocyclic ring haying 1-2 heteroatoms independently selected from nitrogen, oxygen, and sulfur, optionally substituted from 1 to 3 times with R11;
R11 is independently selected at each occurrence from a substituent in the group consisting of halogen, —NO2, —OR12, —NR12R13, —NR12C(O)2R13, —NR12C(O)NR12R13, —S(O)mR13, —CN, —C(O)R13, —C(O)NR12R13, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C6 cycloalkyl, and C4-C7 cycloalkylalkyl, wherein each of C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C6 cycloalkyl, and C4-C7 cycloalkylalkyl is optionally substituted with 1 to 3 substituents independently selected at each occurrence from the group consisting of C1-C4 alkyl, C1-C4 alkoxy, halogen, Ar, —CN, and —NR12R13;
R12 and R13 are each independently hydrogen, C1-C4 alkyl, C1-C4 haloalkyl, C1-C4 alkoxyalkyl, C3-C6 cycloalkyl, —C(O)R14, phenyl, or benzyl, wherein phenyl or benzyl is optionally substituted with 1 to 3 substituents independently selected at each occurrence from the group consisting of halogen, —CN, C1-C4 alkyl, C1-C4 haloalkyl, and C1-C4 alkoxy; or
R12 and R13 are taken together with the nitrogen to which they are attached to form a piperidine, pyrrolidine, piperazine, N-methylpiperazine, morpholine, or thiomorpholine ring;
R14 is C1-C4 alkyl, C1-C4 haloalkyl, or phenyl;
R20 is hydrogen, halogen, —NO2, —OR12, —OX, —NR12R13, —NR12C(O)2R13, —NR12C(O)NR12R13, —S(O)mR13, —CN, —C(O)R13, —C(O)NR12R13, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C7 cycloalkyl, C4-C7 cycloalkylalkyl, heterocycle, aryl, or heteroaryl, wherein each of C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C7 cycloalkyl, C4-C7 cycloalkylalkyl, heterocycle, aryl, and heteroaryl is optionally substituted from 1 to 3 times with R11;
X is a protecting group;
each independently designates a single or double bond; and
n is an integer from 0 to 9;
m is an integer from 0 to 2;
p is an integer from 0 to 3,or a pharmaceutically acceptable salt thereof,said process comprising:providing intermediate compound XVa having the structure:

 andreacting intermediate compound XVa with a reducing agent under conditions effective to produce the product compound of formula XIV, wherein the heterocycle is a stable monocyclic or multi-cyclic 3 to 18 membered ring which consists of carbon atoms and one to five heteroatoms selected from the group of nitrogen, oxygen, and sulfur and the heteroaryl is an aromatic monocyclic or multi-cyclic ring system of about 5 to about 19 ring atoms in which one or more atoms in the ring system are elements other than carbon.

US Pat. No. 10,597,399

SUBSTITUTED TRIAZOLOPIPERAZINE PARP INHIBITOR, PREPARATION METHOD THEREFOR AND USE THEREOF

Shanghai Institute of Mat...

1. A substituted triazolopiperazine compound represented by formula (I), or a tautomer, enantiomer, diastereomer, racemate, pharmaceutically acceptable salt, ester or hydrate thereof:
wherein,
Y is

A and B together with the carbon atoms to which they are attached form a substituted or unsubstituted C4-C8 aliphatic ring, a substituted or unsubstituted C6-C10 aromatic ring, a substituted or unsubstituted 4-8 membered heterocyclic ring containing 1-3 heteratoms selected from N, O and S, or a substituted or unsubstituted 5-8 membered heteroaromatic ring containing 1-3 heteratoms selected from N, O, and S; wherein the substituent in the substituted rings is selected from one or more of the group consisting of halogen, cyano, nitro, hydroxyl, and amino;
X is hydrogen, halogen, hydroxyl, or cyano;
R is halogen, COOR1, substituted or unsubstituted heterocyclic ring, substituted or unsubstituted heteroaromatic ring, substituted or unsubstituted aromatic ring, wherein the substituent in the substituted heterocyclic ring, heteroaromatic ring or aromatic ring is selected from one or more of the group consisting of substituted or unsubstituted C1-C8 alkyl, halogen, cyano, nitro, hydroxyl, amino, C1-C6 alkoxy, C2-C6 alkylcarbonyl, C2-C6 alkoxycarbonyl, C2-C6 alkenyl, C2-C6 alkynyl, and C6-C10 aryl, wherein the substituent in the substituted C1-C8 alkyl is selected from one or more of the group consisting of halogen, cyano, nitro, hydroxyl, amino;
R1 is selected from the group consisting of hydrogen, C1-C8 alkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heterocyclyl, wherein the substituent in the substituted aryl or heterocyclyl is selected from one or more of the group consisting of C1-C8 alkyl, halogen, cyano, nitro, hydroxyl, amino, C1-C6 alkoxy, C2-C6 alkylcarbonyl, C2-C6 alkoxycarbonyl, C2-C6 alkenyl, C2-C6 alkynyl, and C6-C10 aryl.

US Pat. No. 10,597,398

SUPPRESSION AND REGENERATION PROMOTING EFFECT OF LOW MOLECULAR WEIGHT COMPOUND ON CANCER AND FIBROSIS

National University Corpo...

1. A compound, a salt thereof, or a solvate thereof, the compound represented by formula (1):
wherein substituents R1 and R2 are represented by the following case (a) or (b):
(a) R1 is optionally substituted phenyl, and
R2 is H, optionally substituted phenyl, or —C(O)NHR3 where the R3 is H, C1-6 alkyl, or optionally substituted benzyl; or
(b) R1 is optionally substituted naphthyl or optionally substituted phenyl, and
R2 is optionally substituted phenyl or —C(O)NHR4 where the R4 is H, C1-6 alkyl, or optionally substituted siloxybenzyl, and
wherein the term “optionally substituted” means that the respective group is unsubstituted or has a substituent selected from H, halogen, nitro, amino, cyano, OH, C1-6 alkyl, C1-6 halogenoalkyl, C1-6 hydroxyalkyl, C1-6 alkylamino, C3-6 cycloalkyl, C2-6 alkenyl, C2-6 halogenoalkenyl, C2-6 hydroxyalkenyl, C2-6 alkenylamino, C3-6 cycloalkenyl, C2-6 alkynyl, C2-6 halogenoalkynyl, C2-6 hydroxyalkynyl, C2-6 alkynylamino, C1-6 alkoxy, C1-6 halogenoalkoxy, C1-6 hydroxyalkoxy, C1-6 alkoxyamino, C1-6 alkoxyphenyl, trialkylsiloxy, alkyldiphenylsiloxy, aryl, heteroaryl, C1-6 alkoxy-substituted C1-6 alkoxy, C1-6 alkoxyphenyl-substituted C1-6 alkoxy, tri(C1-6 alkylsiloxy)C1_6 alkyl, C1-6 alkyldiphenylsiloxy C1-6 alkyl, triphenylsiloxy C1-6 alkyl, tri(C1-6 alkyl)siloxy, C1-6 alkyldiphenylsiloxy, and triphenylsiloxy, and
the solvate is water, ethanol, or acetic acid.

US Pat. No. 10,597,397

ADENINE CONJUGATE COMPOUNDS AND THEIR USE AS VACCINE ADJUVANTS

Sumitomo Dainippon Pharma...

1. A compound of formula (1):or a pharmaceutically acceptable salt thereof, wherein:L1 and L2 are independently alkylene;
R1 is hydrogen atom or alkyl;
R2 is optionally substituted alkyl;
R3 is hydrogen atom, halogen atom, alkyl or alkoxy;
X1 is single bond, oxygen atom, sulfur atom, SO, SO2, NR4 or CONR4;
R4 is hydrogen atom or alkyl;
A is a monocyclic aromatic carbocycle, a 5-membered aromatic heterocycle which includes 1 to 2 heteroatoms selected from the group consisting of 1 to 2 nitrogen atoms, an oxygen atom, and a sulfur atom, or a 6-membered aromatic heterocycle which includes 1 to 3 heteroatoms selected from the group consisting of 1 to 3 nitrogen atoms, an oxygen atom, and a sulfur atom;
m is 0 or 1; and
each bond described byindependently represents a single bond or a double bond.

US Pat. No. 10,597,396

BETA-LACTAMASE INHIBITORS

Novartis AG, Basel (CH)

1. A compound of Formula (A):wherein p is 1 or 2;R1 and R2 are H;
Z is NR3 ; and
R3 is H;
or a salt or zwitterionic form thereof.

US Pat. No. 10,597,395

PREPARATION OF CERTAIN SUBSTITUTED 1-(4-FLUOROPHENYL)-4-(2,3,6B,9,10,10A-HEXAHYDRO-1H-PYRIDO[3?,4?:4,5]PYRROLO[1,2,3-DE]QUINOXALIN-8(7H)-YL)BUTAN-1-ONES AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF

INTRA-CELLULAR THERAPIES,...

1. A method for preparing a compound of Formula 2J:
or a pharmaceutically acceptable salt thereof,
wherein:
k is 1;
m is 1;
n is 1;
R1 is 4-(4-fluorophenyl)-4-oxobutyl;
R5 is H;
R6a and R6b are independently H;
R7, R8 and R9 are independently H;
R10 is H or CH3; and
X is —N—;
comprising the steps of:
A) reacting a compound of Formula 2E:

wherein:
k is 1;
m is 1;
n is 1;
A is Cl, Br, F, or I;
B is benzyl, triphenylmethyl, or toluenesulfonyl; or
B is a moiety of the formula:

wherein:
P is —C(O)—, —C(O)O—, or —S(O)2—;
Z is C1-6alkyl, aryl, C1-6alkylaryl, or —OR; and
R is C1-6alkyl, aryl, arylC1-6 alkyl, or heteroarylC1-6alkyl;
R5 is H;
R7, R8 and R9 are independently H;
X is —NH(R?);
R? is H or CH3; and
Y is —C(O)—;
with:
(a) a transition metal catalyst selected from the group consisting of palladium, copper, nickel, platinum, ruthenium, and rhodium;
(b) a base; and optionally
(c) a monodentate or bidentate ligand selected from the group consisting of N, N-dimethylformamide, dimethylsulfoxide, 1-methyl-2-pyrrolidinone, an aryl alcohol, a 1,2-diamine, 2-(dimethylamino)glycine, (methylimino)diacetic acid, 8-aminoquinoline, a 1,2-aminoalcohol, an imidazolium carbene, 4-(dimethylamino)pyridine, 2-(aminomethyl)pyridine, 1,8-diazabicyclo[5.4.0]undec-7-ene, 4,7-diphenyl-1,10-phenanthroline, 4,7-dimethyl-1,10-phenanthroline, 5-methyl-1, 10-phenanthroline, 5-chloro-1,10-phenanthroline, and 5-nitro-1,10-phenanthroline;
to give a compound of Formula 2G:

wherein:
k is 1;
m is 1;
n is 1;
B is benzyl, triphenylmethyl, or toluenesulfonyl; or
B is a moiety of the formula:

wherein:
P is —C(O)—, —C(O)O—, or —S(O)2—;
Z is C1-6alkyl, aryl, C1-6alkylaryl, or —OR; and
R is C1-6alkyl, aryl, arylC1-6 alkyl, or heteroarylC1-6alkyl;
R5 is H;
R7, R8 and R9 are independently H;
R10 is H or CH3;
X is —N—; and
Y is —C(O)—;
B) reacting the compound of Formula 2G above with a reducing agent, to give a compound of Formula 2H:

wherein:
k is 1;
m is 1;
n is 1;
B is benzyl, triphenylmethyl, or toluenesulfonyl; or
B is a moiety of the formula:

wherein:
P is —C(O)—, —C(O)O—, or —S(O)2—;
Z is C1-6alkyl, aryl, C1-6alkylaryl, or —OR; and
R is C1-6alkyl, aryl, arylC1-6 alkyl, or heteroarylC1-6alkyl;
R5 is H;
R6a and R6b are independently H;
R7, R8 and R9 are independently H;
R10 is H or CH3; and
X is —N—;
C) deprotecting the compound of Formula 2H above with an acid catalyst, a base catalyst, or via catalytic hydrogenation, to give a compound of Formula 2I:

wherein:
k is 1;
m is 1;
n is 1;
R5 is H;
R6a and R6b are independently H;
R7, R8 and R9 are independently H;
R10 is H or CH3; and
X is —N—;
D) reacting the compound of Formula 2I above with (a) 4-chloro-4?-fluorobutyrophenone, and (b) a base, to give the compound of Formula 2J above; and
E) optionally reacting the compound of Formula 2J with an acid, to give a pharmaceutically acceptable salt of the compound of Formula 2J.

US Pat. No. 10,597,394

ORGANIC COMPOUNDS

INTRA-CELLULAR THERAPIES,...

1. A method for the treatment of a central nervous system disorder selected from anxiety, depression, psychosis, schizophrenia, post-traumatic stress disorder, impulse control disorders and intermittent explosive disorder, comprising administering to a patient in need thereof a therapeutically effective amount of compound of formula I:wherein:R1 is CH3;
R2 and R3 are each independently H or D;
R4 and R5 are each H;
provided that R2 and R3 are not both H,
and wherein D is deuterium;in free or salt form.

US Pat. No. 10,597,392

TETRAHYDROPYRIDOPYRAZINES AS MODULATORS OF GPR6

Takeda Pharmaceutical Com...

1. The compound of formula I
or a pharmaceutically acceptable salt thereof, wherein
R1 is selected from the group consisting of
C3-8 cycloalkyl optionally substituted with 1 to 3 substituents independently selected from the group consisting of C1-4 alkoxy, halo, hydroxy, and C1-4 alkyl optionally substituted with C1-4 alkoxy, halo, and hydroxy;
C3-6 heterocyclyl; optionally substituted on the ring carbons with 1 to 4 substituents independently selected from the group consisting of C1-4 alkyl, C1-4 alkoxy, halo, and hydroxy, and optionally substituted on any ring nitrogen with C1-4 alkyl;
C6-10 aryl optionally substituted with 1 to 5 substituents independently selected from the group consisting of C1-4 alkyl, C1-4 alkoxy, cyano, halo, hydroxy, amino, trifluoromethyl, and trifluoromethoxy; and
C1-10 heteroaryl optionally substituted with 1 to 3 substituents on carbon independently selected from the group consisting of amino, C1-8 alkylamino, C1-9 amide, C1-4 alkyl, C1-4 alkoxy, cyano, halo, hydroxyl, oxo, trifluoromethyl, and trifluoromethoxy, and optionally substituted on a ring nitrogen with a C1-4 alkyl;
X1 is N and X2 is CH; or
X1 is CH and X2 is N; or
X1 is N and X2 is N;
when X1 is N, Z is selected from the group consisting of C1-6 alkylene, C1-6 haloalkylene, —C(O)—, and —S(O)2—;
when X1 is CH, Z is selected from the group consisting of C1-6 alkylene, C1-6 haloalkylene, —O—, —C(O)—, —NH—, —S—, —S(O)—, and —S(O)2—;
q is 0, 1, or 2;
s is 0, 1, or 2;
R2 is —OR5 or —NR6R7;
R3, each time taken, is independently selected from the group consisting of C1-6 alkyl, C3-8 cycloalkyl, and trifluoromethyl;
p is 0, 1, or 2;
R4, each time taken, is independently selected from the group consisting of C1-6 alkyl, hydroxy, and halo;
r is 0 or 1;
R5 is selected from the group consisting of C1-6 alkyl and C3-8 cycloalkyl;
R6 is selected from the group consisting of hydrogen and C1-6 alkyl;
R7 is selected from the group consisting of
optionally substituted C1-6 alkyl optionally substituted with 1 to 7 substituents independently selected from the group consisting of C1-4 alkoxy, C1-9 amide, amino, C1-8 alkylamino, C1-5 oxycarbonyl, cyano, C3-8 cycloalkyl, halo, hydroxy, and C3-6 heterocyclyl optionally substituted on any ring nitrogen by C1-4 alkyl; C1-10 heteroaryl; and phenyl optionally substituted with 1 to 5 substituents independently selected from the group consisting of C1-4 alkyl C1-4 alkoxy, C1-9 amide, amino, C1-8 alkylamino, C1-5 oxycarbonyl, cyano, halo, hydroxyl, nitro, C1-8 sulfonyl, and trifluoromethyl;
C3-8 cycloalkyl;
optionally substituted C6-10 aryl optionally substituted with 1 to 5 substituents independently selected from the group consisting of C1-4 alkyl, C1-4 alkoxy, cyano, halo, hydroxy, amino, trifluoromethyl, and trifluoromethoxy;
optionally substituted C1-10 heteroaryl optionally substituted with 1 to 3 substituents on carbon independently selected from the group consisting of amino, C1-8 alkylamino, C1-9 amide, C1-4 alkyl, C1-4 alkoxy, cyano, halo, hydroxyl, oxo, trifluoromethyl, and trifluoromethoxy, and optionally substituted on a ring nitrogen with a C1-4 alkyl; and
optionally substituted C3-6 heterocyclyl optionally substituted on the ring carbons with 1 to 4 substituents independently selected from the group consisting of C1-4alkyl, C1-4 alkoxy, halo, and hydroxy, and optionally substituted on any ring nitrogen with C1-4 alkyl;
X3 is CCH3 and X4 is N; or
X3 is N and X4 is CCH3;
excluding the compounds:
N-cyclopropyl-3-(4-(2,4-difluorobenzyl)piperazin-1-yl)-7-methylpyrido[3,4-b]pyrazin-2-amine;
3-(4-(5-chloro-2-fluorobenzyl)piperazin-1-yl)-N-cyclopropyl-7-methylpyrido[3,4-b]pyrazin-2-amine;
N-cyclopropyl-3-(4-(2,4-difluorobenzyl)piperidin-1-yl)-7-methylpyrido[3,4-b]pyrazin-2-amine;
N-cyclopropyl-2-(4-(2,4-difluorobenzyl)piperidin-1-yl)-7-methylpyrido[3,4-b]pyrazin-3-amine;
(1-(2-(cyclopropylamino)-7-methylpyrido[3,4-b]pyrazin-3-yl)piperidin-4-yl)(2,5-difluorophenyl)methanone;
N-cyclopropyl-3-(4-(2,4-difluorophenoxy)piperidin-1-yl)-7-methylpyrido[3,4-b]pyrazin-2-amine;
N-cyclopropyl-3-(4-((2,5-difluorophenyl)fluoromethyl)piperidin-1-yl)-7-methylpyrido[3,4-b]pyrazin-2-amine;
(S)—N-cyclopropyl-3-(4-((2,5-difluorophenyl)fluoromethyl)piperidin-1-yl)-7-methylpyrido[3,4-b]pyrazin-2-amine;
3-(4-(4-chloro-2-fluorophenoxy)piperidin-1-yl)-N-cyclopropyl-7-methylpyrido[3,4-b]pyrazin-2-amine;
1-((1-(2-(cyclopropylamino)-7-methylpyrido[3,4-b]pyrazin-3-yl)piperidin-4-yl)methyl)-4-fluoropyridin-2(1H)-one;
(R)—N-cyclopropyl-3-(4-((2,5-difluorophenyl)fluoromethyl)piperidin-1-yl)-7-methylpyrido[3,4-b]pyrazin-2-amine;
N-cyclopropyl-3-(4-((2,4-difluorophenyl)fluoromethyl)piperidin-1-yl)-7-methylpyrido[3,4-b]pyrazin-2-amine;
(R)—N-cyclopropyl-3-(4-((2,4-difluorophenyl)fluoromethyl)piperidin-1-yl)-7-methylpyrido[3,4-b]pyrazin-2-amine;
(S)—N-cyclopropyl-3-(4-((2,4-difluorophenyl)fluoromethyl)piperidin-1-yl)-7-methylpyrido[3,4-b]pyrazin-2-amine;
3-(4-((5-chloro-2-fluorophenyl)difluoromethyl)piperidin-1-yl)-N-cyclopropyl-7-methylpyrido[3,4-b]pyrazin-2-amine;
5-chloro-1-((1-(2-(cyclopropylamino)-7-methylpyrido[3,4-b]pyrazin-3-yl)piperidin-4-yl)methyl)pyridin-2(1H)-one;
N-cyclopropyl-3-(4-((2,5-difluorophenyl)difluoromethyl)piperidin-1-yl)-7-methylpyrido[3,4-b]pyrazin-2-amine;
N-cyclopropyl-3-(4-((4-fluorophenyl)sulfonyl)piperidin-1-yl)-7-methylpyrido[3,4-b]pyrazin-2-amine; and
N-cyclopropyl-3-(1-(2,4-difluorobenzyl)piperidin-4-yl)-7-methylpyrido[3,4-b]pyrazin-2-amine.

US Pat. No. 10,597,391

UREA-CONTAINING ISOXAZOLE DERIVATIVES AS FXR AGONISTS AND METHODS OF USE THEREOF

Enanta Pharmaceuticals, I...

20. A method for treating a disease or condition selected from the group consisting of primary biliary cirrhosis, cerebrotendinous xanthomatosis, primary sclerosing cholangitis, alcoholic liver disease, nonalcoholic fatty liver disease, nonalcoholic steatohepatitis, dyslipidemia, atherosclerosis, hypercholesterolemia, hypertriglyceridemia, and Type II diabetes in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a compound according to claim 1.

US Pat. No. 10,597,390

INDOLES FOR USE IN INFLUENZA VIRUS INFECTION

Janssen Sciences Ireland ...

1. A compound of formula (I)
a stereo-isomeric form, a pharmaceutically acceptable salt, solvate or polymorph thereof, wherein X is N or C wherein when X is C, then X is optionally substituted by —CN, —CF3, —C1-3 alkyl-NH—C(O)—C1-3 alkyl, —C(O)—NH2, —C(O)—NH—C1-3 alkyl, —C(O)—N-(dialkyl) or —CH2—NH—C(O)—CH3;
R1 is F or Cl;
each of R2 and R4 is independently H, halogen, CN, CF3,-O-alkyl or NH2;
R3 is F, Cl, CN, CF3, —C1-3 alkyl, —O-alkyl, carboxylic ester or carboxylic amide;
R5 is Br, CN, CH3, CH2OH, C(O)NH2, NH2 or H;
R6 is C1-8 alkyl substituted by carboxylic acid; C3-8 cycloalkyl substituted by carboxylic acid, —N—C1-3alkylsulfone, —N—C(O)—C3-6heterocycle optionally substituted by C1-6 alkyl; C3-6 heterocycle substituted by —N—C(O)—C3-6 heterocycle; or C3-6 heterocycle substituted by COOH.

US Pat. No. 10,597,386

PROCESS AND INTERMEDIATES FOR THE PREPARATION OF BENZO[B]THIOPHENE COMPOUNDS

Crystal Pharma, S.A.U., ...

1. A process for preparing a compound of formula (I), or a salt or solvate thereof
wherein
R1 is selected from the group consisting of hydrogen, an amino protecting group, —(CH2)n—X, —(CH2)n—OR,

n is an integer from 1 to 6;
X is a leaving group;
R is selected from the group consisting of H and a hydroxyl protecting group;
which process comprises cyclization of a compound of formula (II), or a salt or solvate thereof

wherein
R1 is as defined above;
R2 is selected from the group consisting of —CHO, —CN, —C(O)OR? and —C(O)X?;
X? is halogen;
R? is selected from the group consisting of H, C1-C6 alkyl, C6-C10 aryl and (C6-C10)aryl(C1-C6)alkyl;
R3 is selected from the group consisting of C1-C6 alkyl, C6-C10 aryl, (C6-C10)aryl(C1-C6)alkyl, —C(O)OR?, —C(S)OR? and —C(O)R?; and
R? is selected from the group consisting of C1-C6 alkyl, C6-C10 aryl and (C6-C10)aryl(C1-C6)alkyl.

US Pat. No. 10,597,385

PRODRUG OF 1,1?-(1,6-DIOXO-1,6-HEXANEDIYL)BIS-D-PROLINE

GlaxoSmithKline Intellect...

1. A method of alleviation of symptoms or retardation of progression of AL-type amyloidosis, which method comprises administration of a therapeutically effective amount of a compound which is (2R,2?R)-bis(((((tetrahydro-2H-pyran-4-yl)oxy)carbonyl)oxy)methyl) 1,1?-adipoylbis(pyrrolidine-2-carboxylate) according to Formula (I):

US Pat. No. 10,597,383

BICYCLIC PROLINE COMPOUNDS

Genentech, Inc., South S...

1. A compound of formula (I) or a pharmaceutically acceptable salt thereof:wherein:R1 is selected from aryl and heteroaryl, each optionally substituted with one or more groups independently selected from halogen, —C1-6 alkyl and —C1-6 haloalkyl;
m is 0, 1 or 2;
each R2 is independently selected from —C1-6 alkyl;
R3 is a 4-, 5-, 6- or 7-membered heteraryl optionally substituted with one or more groups independently selected from halogen, —C1-6 alkyl, —C1-6 haloalkyl, —O—C1-6 alkyl, and —CN; and
A is selected from A1, A2 and A3 wherein:
A1 unsubstituted or substituted 5-membered heteroaryl comprising one or two nitrogen hetero atoms;
A2 is unsubstituted or substituted aryl; and
A3 is unsubstituted or substituted 6-membered heteroaryl comprising one or two nitrogen hetero atoms.

US Pat. No. 10,597,382

TETRAZOLE CONTAINING APOPTOSIS SIGNAL-REGULATING KINASE 1 INHIBITORS AND METHODS OF USE THEREOF

Enanta Pharmaceuticals, I...

1. A compound represented by Formula I or a pharmaceutically acceptable salt, ester, or combination thereof:
wherein
R1 is selected from

wherein R5 is selected from the group consisting of:
1) Hydrogen;
2) Optionally substituted —C1-C8 alkyl;
3) Optionally substituted —C2-C8 alkenyl;
4) Optionally substituted —C2-C8 alkynyl;
5) Optionally substituted —C3-C8 cycloalkyl;
6) Optionally substituted aryl;
7) Optionally substituted arylalkyl;
8) Optionally substituted 3- to 8-membered heterocycloalkyl;
9) Optionally substituted heteroaryl; and
10) Optionally substituted heteroarylalkyl;
X1, X2, X3 and X4 are each independently selected from N and C(R6);
R2 and R6 are each independently selected from the group consisting of:
1) Hydrogen;
2) Halogen;
3) —NO2;
4) Cyano;
5) Optionally substituted —C1-C8 alkyl;
6) Optionally substituted —C1-C8 cycloalkyl; and
7) Optionally substituted 3- to 8-membered heterocycloalkyl;
R3 and R4 are each independently selected from the group consisting of:
1) Hydrogen;
2) Halogen;
3) —NO2;
4) Cyano;
5) Optionally substituted —C1-C8 alkyl;
6) Optionally substituted —C2-C8 alkenyl;
7) Optionally substituted —C2-C8 alkynyl;
8) Optionally substituted —C3-C8 cycloalkyl;
9) Optionally substituted aryl;
10) Optionally substituted arylalkyl;
11) Optionally substituted 3- to 8-membered heterocycloalkyl;
12) Optionally substituted heteroaryl;
13) Optionally substituted heteroarylalkyl;
14) —OR7;
15) —N(R7)(R8);
16) —S(O)2N(R7)(R8);
17) —N(R7)C(O)R8; and
18) —N(R7)S(O)2R8;
wherein R7 and R8 are independently selected from the group consisting of hydrogen, —C1-C15 alkyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl, each of which is optionally substituted with 0 to 3 substituents selected from halo, alkyl, mono- or dialkylamino, alkylamido, arylamido, heteroarylamido, —CN, lower alkoxy, —CF3, aryl, and heteroaryl, or R7 and R8 are taken together with the nitrogen atom to which they are attached to form a heterocyclics;
provided that each optionally substituted group is independently optionally substituted with one or more substituents selected from deuterium, —F, —Cl, —Br, —I, —OH, protected hydroxy, —NO2, —CN, —NH2, N3, protected amino, alkoxy, thioalkoxy, oxo, —C1-C12-alkyl, —C2-C12-alkenyl, —C2-C12-alkynyl, —C3-C12-cycloalkyl, -heterocycloalkyl, -halo-C1-C12-alkyl, -halo-C2-C12-alkenyl, -halo-C2-C12-alkynyl, -halo-C3-C12-cycloalkyl, —NH—C1-C12-alkyl, —NH—C2-C12-alkenyl, —NH—C2-C12-alkynyl, —NH—C3-C12-cycloalkyl, —NH-aryl, —NH-heteroaryl, —NH-heterocycloalkyl, -dialkylamino, -diarylamino, -diheteroarylamino, —O—C1-C12-alkyl, —O—C2-C12-alkenyl, —O—C2-C12-alkynyl, —O—C3-C12-cycloalkyl, —O-aryl, —O-heteroaryl, —O-heterocycloalkyl, —C(O)—C1-C12-alkyl, —C(O)—C2-C12-alkenyl, —C(O)—C2-C12-alkynyl, —C(O)—C3-C12-cycloalkyl, —C(O)-aryl, —C(O)-heteroaryl, —C(O)-heterocycloalkyl, —CONH2, —CONH—C1-C12-alkyl, —CONH—C2-C12-alkenyl, —CONH—C2-C12-alkynyl, —CONH—C3-C12-cycloalkyl, —CONH-aryl, —CONH-heteroaryl, —CONH-heterocycloalkyl, —OCO2—C1-C12-alkyl, —OCO2—C2-C12-alkenyl, —OCO2—C2-C12-alkynyl, —OCO2—C3-C12-cycloalkyl, —OCO2-aryl, —OCO2-heteroaryl, —OCO2-heterocycloalkyl, —OCONH2—, —OCONH—C1-C12alkyl, —OCONH—C2-C12-alkenyl, —OCONH—C2-C12-alkynyl, —OCONH—C3-C12-cycloalkyl, —OCONH-aryl, —OCONH-heteroaryl, —OCONH-heterocycloalkyl, —NHC(O)—C1-C12-alkyl, —NHC(O)—C2-C12-alkenyl, —NHC(O)—C2-C12-alkynyl, —NHC(O)—C3-C12-cycloalkyl, —NHC(O)-aryl, —NHC(O)-heteroaryl, —NHC(O)-heterocycloalkyl, —NHCO2—C1-C12-alkyl, —NHCO2—C2-C12-alkenyl, —NHCO2—C2-C12-alkynyl, —NHCO2—C3-C12-cycloalkyl, —NHCO2-aryl, —NHCO2-heteroaryl, —NHCO2-heterocycloalkyl, —NHC(O)NH2, —NHC(O)NH—C1-C12alkyl, —NHC(O)NH—C2-C12-alkenyl, —NHC(O)NH—C2-C12-alkynyl, —NHC(O)NH—C3-C12-cycloalkyl, —NHC(O)NH-aryl, —NHC(O)NH-heteroaryl, —NHC(O)NH-heterocycloalkyl, NHC(S)NH2, —NHC(S)NH—C1-C12—NHC(S)NH—C2-C12-alkenyl, —NHC(S)NH—C2-C12-alkynyl, —NHC(S)NH—C3-C12-cycloalkyl, —NHC(S)NH-aryl, —NHC(S)NH-heteroaryl, —NHC(S)NH-heterocycloalkyl, —NHC(NH)NH2, —NHC(NH)NH—C1-C12-alkyl, —NHC(NH)NH—C2-C12-alkenyl, —NHC(NH)NH—C2-C12-alkynyl, —NHC(NH)NH—C3-C12-cycloalkyl, —NHC(NH)NH-aryl, —NHC(NH)NH-heteroaryl, —NHC(NH)NH-heterocycloalkyl, —NHC(NH)—C1-C12-alkyl, —NHC(NH)—C2-C12-alkenyl, —NHC(NH)—C2-C12-alkynyl, —NHC(NH)—C3-C12-cycloalkyl, —NHC(NH)-aryl, —NHC(NH)-heteroaryl, —NHC(NH)-heterocycloalkyl, —C(NH)NH—C1-C12-alkyl, —C(NH)NH—C2-C12-alkenyl, —C(NH)NH—C2-C12-alkynyl, —C(NH)NH—C3-C12-cycloalkyl, —C(NH)NH-aryl, —C(NH)NH-heteroaryl, —C(NH)NH-heterocycloalkyl, —S(O)—C1-C12-alkyl, —S(O)—C2-C12-alkenyl, —S(O)—C2-C12-alkenyl, —S(O)—C3-C12-cycloalkyl, —S(O)-aryl, —S(O)-heteroaryl, —S(O)-heterocycloalkyl-SO2NH2, —SO2NH—C1-C12-alkyl, —SO2NH—C2-C12-alkenyl, —SO2NH—C2-C12-alkynyl, —SO2NH—C3-C12-cycloalkyl, —SO2NH-aryl, —SO2NH-heteroaryl, —SO2NH-heterocycloalkyl, —NHSO2—C1-C12-alkyl, —NHSO2—C2-C12-alkenyl, —NHSO2—C2-C12-alkynyl, —NHSO2—C3-C12-cycloalkyl, —NHSO2-aryl, —NHSO2-heteroaryl, —NHSO2-heterocycloalkyl, —CH2NH2, —CH2SO2CH3, -aryl, -arylalkyl, -heteroaryl, -heteroarylalkyl, -heterocycloalkyl, —C3-C12-cycloalkyl, polyalkoxyalkyl, polyalkoxy, -methoxymethoxy, -methoxyethoxy, —SH, —S—C1-C12-alkyl, —S—C2-C12-alkenyl, —S—C2-C12-alkynyl, —S—C3-C12-cycloalkyl, —S-aryl, —S-heteroaryl, —S-heterocycloalkyl, methylthiomethyl, and -L?-R?, wherein L? is C1-C6alkylene, C2-C6alkenylene or C2-C6alkynylene, and R? is aryl, heteroaryl, heterocyclic, C3-C12cycloalkyl or C3-C12cycloalkenyl.

US Pat. No. 10,597,381

COMPOUNDS, COMPOSITIONS, AND METHODS FOR MODULATING FERROPTOSIS AND TREATING EXCITOTOXIC DISORDERS

THE TRUSTEES OF COLUMBIA ...

1. A method for treating or ameliorating the effects of a neurodegenerative disease in a subject in need thereof comprising administering to the subject an effective amount of a compound having the structure:or pharmaceutically acceptable salts thereof.

US Pat. No. 10,597,380

PYRIDAZINONE-BASED BROAD SPECTRUM ANTI-INFLUENZA INHIBITORS

Hoffmann-La Roche Inc., ...

1. A compound of formula (I)
wherein
X is —CH2—CH2—CH2—, —CH?CH—CH?CH—, —CH2—CH2—CH2—CH2—, —CH2—O—CH2—CH2—, CH2—CH2—O—CH2—, —CH2—NR2—CH2—CH2—, or —CH2—CH2—NR2—CH2—;
n is 0, 1 or 2;
each R1 is independently selected from halo, C1-7 alkyl, C2-7 alkenyl, hydroxy, C1-7 alkoxy, NR10R11, and CONR10R11;
wherein C1-7 alkyl and C1-7 alkoxy are optionally substituted by one or more C1-7 alkyl, hydroxy, C1-7 alkoxy, NR10R11 or COR9;
R2 is H, C1-7 alkyl, hydroxy-C1-7 alkyl, COR9, CONR10R11, or SO2—C1-7 alkyl;
Y1 is N, CH or CCH3,
Y2 is N or CR3;
with the proviso that not both of Y1 and Y2 are N;
R3 is H, halogen, C1-7 alkyl, halo-C1-7 alkyl, CONR10R11 or CO—C1-7 alkoxy;
R4 is H or C1-7 alkyl, wherein C1-7 alkyl is optionally substituted with one or more R5;
each R5 is independently selected from hydroxy, C1-7 alkoxy, NR12R13, COR9, CONR10R11,SO2—C1-7 alkyl, SO2—NR10R11, heterocycloalkyl and heteroaryl;
wherein C1-7 alkoxy is optionally substituted by COR9 or CONR10R11;
wherein heterocycloalkyl and heteroaryl are optionally substituted with one or more substituents selected from halo, C1-7 alkyl, halo-C1-7 alkyl, hydroxy, C1-7 alkoxy, oxo, COR9, C1-7 alkyl-COR9 or NR10R11;
Z1 is N, CH or CO—CH3;
Z2 is N or CH;
R6 is C1-7 alkyl, hydroxy-C1-7 alkyl, halo-C1-7 alkyl, C1-7 alkoxy-C1-7 alkyl, C1-7 alkoxy,halo-C1-7 alkoxy, C1-7 alkoxy-C1-7 alkoxy, S-halo-C1-7 alkyl, SF5, C3-7 cycloalkyl,heterocycloalkyl or heterocycloalkyl substituted by C1-7 alkyl;
R7 is H, halogen or C1-7 alkyl;
R8 is H, halogen or C1-7 alkyl;
R9 is H, C1-7 alkyl, hydroxy, or C1-7 alkoxy;
R10 is H or C1-7 alkyl;
wherein C1-7 alkyl is optionally substituted with one or more hydroxy, C1-7 alkoxy, COOH, or CO—C1-7 alkoxy;
R11 is H, C1-7 alkyl, CO—C1-7 alkoxy or heterocycloalkyl;
wherein C1-7 alkyl is optionally substituted with one or more hydroxy, C1-7 alkoxy,NH2, N(C1-7 alkyl)2, COOH, or CO—C1-7 alkoxy;
or R10 and R11 together with the interconnecting nitrogen form a heterocycloalkyl which is optionally substituted with one or more halo, C1-7 alkyl, halo-C1-7 alkyl, hydroxy,C1-7 alkoxy, oxo, COOH, CO—C1-7 alkoxy or NH2;
R12 is H or C1-7 alkyl;
wherein C1-7 alkyl is optionally substituted with one or more hydroxy, C1-7 alkoxy, COOH, or CO—C1-7 alkoxy;
R13 is H, C1-7 alkyl, CO—C1-7 alkoxy or heterocycloalkyl,
wherein C1-7 alkyl is optionally substituted with one or more hydroxy, C1-7 alkoxy, NH2, N(C1-7 alkyl)2, COOH, or CO—C1-7 alkoxy;
or a pharmaceutically acceptable salt thereof.

US Pat. No. 10,597,377

SOMATOSTATIN MODULATORS AND USES THEREOF

CRINETICS PHARMACEUTICALS...

1. A compound that has the following structure:
or a pharmaceutically acceptable salt, or solvate thereof.

US Pat. No. 10,597,376

INHIBITORS OF LYSINE SPECIFIC DEMETHYLASE-1

Celgene Quanticel Researc...

1. A compound, or a pharmaceutically acceptable salt thereof, having the structure of Formula (I):
wherein,
A is N or CH;
W1 and W2 are independently chosen from N, C—H, or C—F;
X is hydrogen, halogen, optionally substituted aryl, or optionally substituted heteroaryl;
Y is optionally substituted alkyl, optionally substituted cycloalkylalkyl, optionally substituted heterocyclylalkyl, or optionally substituted aralkyl; and
Z is an optionally substituted group chosen from N-heterocyclyl, —O-heterocyclylalkyl, —N(H)-heterocyclylalkyl, or —N(Me)-heterocyclylalkyl;
wherein if Z is an optionally substituted heterocyclylalkyl group selected from —O— heterocyclylalkyl, —N(H)-heterocyclylalkyl or —N(Me)-heterocyclylalkyl, then heterocyclylalkyl group has the formula —Rc-heterocyclyl, wherein Rc is an optionally substituted C1-C3 alkylene chain and the heterocyclyl is an optionally substituted nitrogen-containing 5-membered heterocyclyl.

US Pat. No. 10,597,375

HALOGEN-SUBSTITUTED HETEROCYCLIC COMPOUND

UBE INDUSTRIES, LTD., Ub...

1. A method of suppressing an LPA1 receptor, comprising:administering a therapeutically effective amount of a compound or a pharmacologically acceptable salt thereof as an active ingredient and an additive;
wherein the compound is represented by the formula (I):
whereinA represents a phenyl ring;
R1 is the same or different, and represents a halogen atom, or a C1-C3 alkyl group;
R2 represents a hydrogen atom, or a C1-C6 alkyl group;
p represents an integer of 0 to 5;
V represents CR3 wherein R3 represents a hydrogen atom, an amino group, a nitro group, or a C1-C3 alkoxy group;
X represents a halogen atom.

US Pat. No. 10,597,372

SIMPLIFIED STRUCTURAL MIMETICS OF AIPS AS QUORUM SENSING INHIBITORS

Wisconsin Alumni Research...

12. A compound of formula:
or salts or solvates thereof,
where:
W is S or NR1, where R1 is hydrogen or an alkyl group having 1 to 3 carbon atoms;
each R is hydrogen or methyl;
Z is —NR3CO—R2, where R3 is hydrogen or a C1-C3 alkyl, and R2 is hydrogen, an optionally-substituted alkyl group having 1-12 carbon atoms, an optionally-substituted cycloalkyl group having 3-12 carbon atoms, an optionally-substituted arylalkyl group, an optionally-substituted heteroarylalkyl group, an optionally-substituted heterocyclylalkyl group, an optionally-substituted cycloalkylalkyl group, an optionally-substituted aryl, an optionally-substituted heteroaryl group, an optionally-substituted heterocyclyl group or an alkoxyalkyl group having 1-12 carbon atoms and 1-4 oxygen atoms; wherein optional substitution of R2 is substitution with one or more groups selected from the group consisting of halogen, hydroxyl, nitro, cyano, isocyano, oxo, thioxo, azide, cyanate, isocyanate, acyl, haloakyl, alkyl, alkenyl, alkynyl, phenyl, halo-substituted phenyl, alkyl-substituted phenyl, benzyl, halo-substituted benzyl, alkyl-substituted benzyl, alkoxy, alkylthio, and mercapto;
X1 and X2 are optionally substituted benzyl, cyclohexyl, cyclopentyl, or 3-indolylmethyl, where optional substitution is substitution with one or more halogen, hydroxyl, alkyl or alkoxy; and
L1 is an alkoxyalkylene having 2-8 carbons and 1-3 oxygens.

US Pat. No. 10,597,370

2-(BENZOTHIAZOL-2-YL)-2-CYANO-ACETAMIDE DERIVATIVES AND THEIR USE AS ENDOTHELIAL LIPASE INHIBITORS

Bristol-Myers Squibb Comp...

1. A compound of Formula (I):or a stereoisomer, a tautomer, or a pharmaceutically acceptable salt or a solvate thereof, wherein:G is N or C;
R1 is phenyl, a 5- or 6-membered heteroaryl, or a 5- or 6-membered non-aromatic heterocyclyl; wherein the heteroaryl or non-aromatic heterocyclyl each independently comprises one or more carbon atoms and 1 to 4 heteroatoms selected from N, NRa, O, and S(O)Z, and the phenyl, heteroaryl or non-aromatic heterocyclyl is each independently substituted with 0, 1, 2, or 3 R6;
R2 is, independently at each occurrence, selected from: halogen, OH, C1-4 alkyl, C1-4 alkoxy, C1-4 haloalkyl, C1-4 haloalkoxy, CN, NRbRc, NO2, CO2Rd, and CONRbRc;
R3 is —(CH2)Y—CONReR4;
Re is hydrogen, C1-4 alkyl, or C3-6 carbocyclyl;
R4 is C1-6 alkyl substituted with 0, 1, or 2 R7, —(CH2)Q—(C3-6 carbocyclyl substituted with 0, 1, or 2 R7), or —(CH2)Q-(4- to 6-membered heterocyclyl comprising one or more carbon atoms and 1 to 4 heteroatoms selected from N, NRa, O, and S(O)Z, wherein the heterocycle is substituted with 0, 1, or 2 R7; or alternatively, Re and R4, taken together with the atoms to which they are attached, form a 5- or 6-membered azacyclyl comprising one or more carbon atoms and 1 to 4 heteroatoms selected from N, NRa, O, and S(O)Z, wherein the azacyclyl is substituted with 0, 1, or 2 R5;
R6 is, independently at each occurrence, selected from: OH, halogen, C1-6 alkyl, C1-4 alkoxy, C1-4 haloalkyl, C1-4 haloalkoxy, NRfRg, OPh, OBn, Ph, and —CONRhRi; or alternatively, two R6, taken together with the atoms to which they are attached, form a 5- or 6-membered carbocyclyl, heteroaryl or non-aromatic heterocyclyl; wherein the heteroaryl or non-aromatic heterocyclyl each independently comprises one or more carbon atoms and 1 to 4 heteroatoms selected from N, NRa, O, and S(O)Z, and the carbocyclyl, heteroaryl or non-aromatic heterocyclyl is each independently substituted with 0, 1, 2, or 3 R8;
R5, R7, R8, and R9 are, independently at each occurrence, selected from: OH, halogen, C1-6 alkyl, C1-4 alkoxy, C1-4 haloalkyl, C1-4 haloalkoxy, NRjRk, OPh, OBn, Ph, and a 5- or 6-membered heteroaryl comprising one or more carbon atoms and 1 to 4 heteroatoms selected from N, NRa and O;
Ra, Rb, Rc, Rd, Re, Rj, and Rk are, independently at each occurrence, hydrogen, C1-4 alkyl, or C3-6 carbocyclyl;
Rf and Rg are independently hydrogen, C1-4 alkyl, C3-6 carbocyclyl, CO2Rm, or CONRnRp;
Rh and Ri are independently hydrogen, C1-4 alkyl, C3-6 carbocyclyl, C1-4 alkoxy, C1-4 haloalkyl, C1-4 haloalkoxy; or alternatively, Rh and Ri, taken together with the atoms to which they are attached, form a 5- or 6-membered azacyclyl comprising one or more carbon atoms and 1 to 4 heteroatoms selected from N, NRa, O, and S(O)Z, wherein the azacyclyl is substituted with 0, 1, or 2 R9;
Rm, Rn, and Rp are independently hydrogen, C1-4 alkyl, C3-6 carbocyclyl, C1-4 alkoxy, C1-4 haloalkyl, C1-4 haloalkoxy, aryl, arylalkyl, or a 5- or 6-membered heteroaryl comprising one or more carbon atoms and 1 to 4 heteroatoms selected from N, NRa and O;
X is 0, 1, 2, or 3;
Y is 1, 2, or 3;
Z is, independently at each occurrence, 0, 1, or 2; and
Q is, independently at each occurrence, 0, 1, 2 or 3.

US Pat. No. 10,597,369

MONOSULFONIC PHENYLTETRAZOLE COMPOUNDS WITH APPLICATIONS

HANGZHOU JENNIFER BIOTECH...

1. A composition of Monosulfonic phenyltetrazole compounds which are selected from the following compounds:

US Pat. No. 10,597,368

SYRINGOLIN ANALOGUES AND METHODS OF MAKING AND USING SAME

BROWN UNIVERSITY, Provid...

1. A compound of formula (I), or a salt, racemic mixture, enantiomer, pro-drug, or diastereoisomer thereof:
wherein:
R is arylalkyl, or heteroarylalkyl, wherein each one of the arylalkyl or heteroarylalkyl groups is independently optionally substituted with one or more of C1-C6 alkyl, haloalkyl, F, Cl, Br, I, C1-C6 alkoxy, or hydroxy;
R? is C1-C6 alkyl or arylalkyl, wherein each one of the alkyl or arylakyl groups is independently optionally substituted with one or more of C1-C6 alkyl, haloalkyl, F, Cl, Br, I, C1-C6 alkoxy, or hydroxy; and
R? is H or C1-C16 alkyl, wherein each one of the alkyl groups is independently optionally substituted with one or more of C1-C6 alkyl, F, Cl, Br, I, C1-C6 alkoxy, or hydroxy.

US Pat. No. 10,597,367

METABOTROPIC GLUTAMATE RECEPTOR NEGATIVE ALLOSTERIC MODULATORS (NAMS) AND USES THEREOF

SANFORD BURNHAM PREBYS ME...

11. A compound, or a pharmaceutically acceptable salt thereof, having the structure of Formula (IV):
wherein:
Z is ?N— or ?C(H)—;
R1 is halogen, —OR5, —NO2, —CN, substituted or unsubstituted C1-C6alkyl, substituted or unsubstituted C1-C6fluoroalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, or —CO2R6;
R2 is halogen, —OR5, NO2, substituted or unsubstituted C1-C6alkyl, or substituted or unsubstituted C1-C6fluoroalkyl;
R3 is halogen, substituted or unsubstituted C1-C6alkyl, substituted or unsubstituted C1-C6fluoroalkyl, substituted or unsubstituted C3-C6cycloalkyl, substituted or unsubstituted C2-C7heterocycloalkyl, substituted or unsubstituted aryl, unsubstituted heteroaryl, —C(O)NR9R10, or —X—R4;
X is —O—, —S—, —S(O)2—, —N(R7)—, or —C?C—;
R4 is substituted or unsubstituted C1-C6alkyl, substituted or unsubstituted C3-C6cycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
each R5 is independently hydrogen or substituted or unsubstituted C1-C6alkyl;
R6 is hydrogen or substituted or unsubstituted C1-C6alkyl;
R7 is hydrogen or substituted or unsubstituted C1-C6alkyl;
R8 is halogen or substituted or unsubstituted C1-C6alkyl;
R9 and R10 are independently hydrogen or substituted or unsubstituted C1-C6alkyl;
n is 0, 1, 2, or 3; and
m is 0, 1, or 2.

US Pat. No. 10,597,366

ARYL ETHERS AND USES THEREOF

Peloton Therapeutics, Inc...

1. A process for preparing 3-[(1S,2S,3R)-2,3-difluoro-1-hydroxy-7-methylsulfonyl-indan-4-yl]oxy-5-fluoro-benzonitrile, comprising:(i) fluorinating a compound of Formula A:

to provide a compound of Formula B:
and(ii) deprotecting the compound of Formula B to provide 3-[(1S,2S,3R)-2,3-difluoro-1-hydroxy-7-methylsulfonyl-indan-4-yl]oxy-5-fluoro-benzonitrile, represented by the formula:

wherein P is a protecting group.

US Pat. No. 10,597,365

HISTONE DEMETHYLASE INHIBITORS

CELGENE QUANTICEL RESEARC...

1. A compound of Formula (XI), or a pharmaceutically acceptable salt thereof,
wherein:
Q is —CO2R;
R is hydrogen or optionally substituted alkyl;
G is —X—Y;
X is methylene;
Y is optionally substituted monocyclic or bicyclic aryl or heteroaryl containing at least one O or S atom; and
provided that Y is not an unsubstituted phenyl.

US Pat. No. 10,597,363

METHODS FOR PREPARING N-(4-FLUOROBENZYL)-N-(1-METHYLPIPERIDIN-4-YL)-N?-(4-(2-METHYLPROPYLOXY)PHENYLMETHYL)CARBAMIDE AND ITS TARTRATE SALT AND POLYMORPHIC FORM C

ACADIA Pharmaceuticals In...

1. A method of preparing pimavanserin (N-(4-fluorophenylmethyl)-N-(1-methylpiperidin-4-yl)-N?-(4-(2-methylpropyloxy)phenylmethyl)carbamide) or a salt thereof, the method comprising:contacting isobutyl alcohol with 4-fluorobenzonitrile to produce 4-isobutoxybenzonitrile;
converting the 4-isobutoxybenzonitrile to (4-isobutoxyphenyl)methanamine;
contacting the (4-isobutoxyphenyl)methanamine with
to produce an intermediate according to Formula (A2),
wherein
X is OR1 or Cl;
Y is OR1; and
R1 is selected from the group consisting of substituted or unsubstituted C1-6 alkyl, and substituted or unsubstituted aryl:
contacting the intermediate according to Formula (A2)with an intermediate according to Formula (B2),to produce pimavanserin; andoptionally, contacting the pimavanserin produced from the previous step with an acid to produce a pimavanserin salt.

US Pat. No. 10,597,362

3-AMINOALKYLATED INDOLE DERIVATIVE, METHOD FOR THE PREPARATION THEREOF, AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME

Seoul National University...

1. A compound represented by the following Chemical Formula 1, or a pharmaceutically acceptable salt thereof:
in Chemical Formula 1,
R1 is hydrogen, or C1-4 alkyl,
R2 is hydrogen, C1-4 alkyl, C1-4 alkoxy, C1-4 haloalkyl, or halogen,
R3 is hydrogen, or halogen,
X is N—R4, and
R4 is hydrogen, or C1-4 alkyl.

US Pat. No. 10,597,360

PREPOLYMERS EXHIBITING RAPID DEVELOPMENT OF PHYSICAL PROPERTIES

PRC-DeSoto International,...

1. A polythioether prepolymer comprising reaction products of reactants comprising:(a) a polythiol comprising a dithiol of Formula (5):
HS—R1—SH  (5)
wherein,
R1 comprises C2-10 alkanediyl, C6-8 cycloalkanediyl, C6-10 alkanecycloalkanediyl, C5-8 heterocycloalkanediyl, or —[(—CHR—)p—X—]q—(—CHR—)r—, wherein:
each p is independently an integer from 2 to 6;
q is an integer from 1 to 5;
r is an integer from 2 to 10;
each R is independently selected from hydrogen and methyl; and
each X is independently selected from —O—, —S—, and —NR5—, wherein R5 is selected from hydrogen and methyl;
(b) a hydroxyl-containing bis(alkenyl) ether of Formula (2):
CH2=CH—(CH2)n—O—(CH2)n—CH(—OH)—CH2—S—R4—S—CH2—CH(—OH)—(CH2)n—O—(CH2)n—CH?CH2  (2)
wherein,
each n is independently an integer from 1 to 4; and
R4 is selected from C2-6 n-alkanediyl, C3-6 branched alkanediyl, C6-8 cycloalkanediyl, C6-10 alkanecycloalkanediyl, and —[(—CH2—)p—X—]q—(—CH2—)r—, wherein,
each X is independently selected from —O—, —S— and —S—S—;
each p is independently an integer from 2 to 6;
q is an integer from 1 to 5; and
r is an integer from 2 to 6; and
(c) a divinyl ether of Formula (3):
CH2=CH—O—(—R2—O—)m—CH?CH2  (3)
wherein,
m is an integer from 0 to 50; and
each R2 is selected from C2-6 n-alkanediyl, C3-6 branched alkanediyl, C6-8 cycloalkanediyl, C6-10 alkanecycloalkanediyl, and —[(—CH2—)p—O—]q—(—CH2—)r—, wherein,
each p is independently an integer from 2 to 6;
q is an integer from 1 to 5; and
r is an integer from 2 to 10.

US Pat. No. 10,597,359

HIGH-SOLUBILITY THIOETHER QUINONES

Wisconsin Alumni Research...

1. A substituted hydroquinone having the formula:
wherein one, two, three, or all four of R1, R2, R3 and R4 comprise a thioether moiety and a sulfonate moiety, and wherein each R1, R2, R3 and R4 that does not comprise a thioether and a sulfonate moiety is independently a hydrogen, an alkyl, or an electron withdrawing group; or
the oxidized form (the substituted 1,4-benzoquinone form) of said substituted hydroquinone.

US Pat. No. 10,597,358

SYNTHESIS OF CARBAMATE OR UREA COMPOUNDS

Nederlandse Organisatie v...

1. A method for preparing an N,N-diaryl substituted urea derivative for nitrocellulose stabilization, said method comprising a first step of preparing a carbamate according to formula I, comprising reacting an amine according to formula II and a compound according to formula III, in the presence of a catalyst that comprises an N,N-dialkylimidazolium ionic liquid or a non-nucleophilic basewhereinAr1 is an aryl that is optionally substituted with one or more of halide, alkoxy, alkyl, nitro, sulfonate, ester, amide and/or carboxylate;
Ar2 is Ar1 or an aryl that is optionally substituted with one or more of halide, alkoxy, alkyl, nitro, sulfonate, ester, amide and/or carboxylate;
X is an alkoxy, or an aryloxy and is optionally substituted with one or more of halide, alkoxy, alkyl, nitro, sulfonate, ester, amide and/or carboxylate; and
LG is an alkoxy, an aryloxy, an amine that is optionally substituted with one or two C1-C4 alkyl groups, an amide, a sulfonate, a halide, a nitrate, a phosphate or a carboxylate;
wherein the catalyst is present in less than 50 mol % with respect to the amine according to formula II; and
followed by a second step wherein the carbamate according to formula I is reacted with an amine to form said N,N-diaryl substituted urea derivative for nitrocellulose stabilization.

US Pat. No. 10,597,355

1,1-DISUBSTITUTED ETHYLENE PROCESS

OptMed, Inc., New York, ...

1. A method of producing methylidene malonates and cyanoacrylates which method comprises reacting(A) (i) a malonic acid ester corresponding to the formula VI:

wherein R1 is hydrogen (H) and R2 is a C1 to C18 hydrocarbon or heterohydrocarbon group, the latter having one or more nitrogen, halogen, or oxygen atoms or both R1 and R2 are independently a C1 to C18 hydrocarbon or heterohydrocarbon group; the latter having one or more nitrogen, halogen, or oxygen atoms or
(ii) a cyanoacetate corresponding to the formula V:
CH2(CN)CO2R2
wherein R2 is a C1 to C18 hydrocarbon or heterohydrocarbon group, the latter having one or more nitrogen, halogen, or oxygen atoms, respectively, with
(B) an iminium salt corresponding to the formula

wherein R4 and R5 are both hydrogen (H) and R6 and R7 are each independently a C1 to C10 hydrocarbon or substituted hydrocarbon or together form a bridge whereby the nitrogen atom, R6 and R7 together form a ring structure; provided that neither of R6 and R7 is a hydrocarbon moiety comprising a tertiary carbon attached to the N atom, and X is a halogen, a carboxylate or a sultanate anion,
in the presence of
(C) from 0.2 to 1.0 equivalents based on the iminium salt (B) of (i) an acid halide of the formula R9C(O)X or R9SO2X, (ii) an acid anhydride of the formula R9C(O)2O or (iii) both (i) and (ii), wherein R9 is an aliphatic or aromatic C1 to C18 hydrocarbon or substituted hydrocarbon and X is fluorine, chlorine, bromine or iodine.

US Pat. No. 10,597,351

METHOD FOR PREPARING SELEGILINE BASE

Dipharma Francis S.r.L., ...

1. A process for the preparation of selegiline base of formula (I):comprising:a) reacting the hydrochloride addition salt of selegiline of formula (II)
with a base in an aqueous solution forming a biphasic mixture;b) separating any selegiline base of formula (I) from the aqueous solution; and
c) anhydrifying by drying the selegiline base of formula (I) or by freezing the selegiline base of formula (I) at a temperature below 0° C.,
wherein the ratio of the hydrochloride addition salt of selegiline of formula (II) and the aqueous content during step a) is equal or superior to 100 mg/1 mL water.

US Pat. No. 10,597,349

PROCESS FOR PURIFICATION OF METHYL METHACRYLATE

Dow Global Technologies L...

1. A process for purifying methyl methacrylate; said method comprising: (a) feeding a reaction product mixture comprising methanol, methyl methacrylate and alkali metal salt thereof, methacrolein, water and heavy byproducts to a distillation column having at least 15 trays; wherein said reaction product mixture and a C6-C7 hydrocarbon enter the distillation column above the middle of the distillation column; (b) removing an overhead stream comprising C6-C7 hydrocarbon, methacrolein, methanol, water and methyl methacrylate; and (c) removing a bottoms stream comprising water, methyl methacrylate and its alkali metal salt and heavy byproducts.

US Pat. No. 10,597,348

INFUSING RAW CANNABINOIDS INTO FOOD OIL

1. A method comprising:(a) collecting and drying raw cannabis material having a desired cannabinoid profile, wherein the cannabinoid profile comprises an amount of cannabinoids, and wherein the cannabinoid profile does not include any decarboxylated cannabinoids;
(b) blending the cannabis material with oil thereby obtaining a cannabis infused oil mixture, wherein the blending is performed without causing cannabinoids in the cannabis infused oil mixture to become decarboxylated; and
(c) filtering cannabis material out of the cannabis infused oil mixture thereby obtaining a cannabis infused oil, wherein the cannabis infused oil is formed without using any alcohol or ethanol in the steps of (a), (b), and (c).

US Pat. No. 10,597,341

METHOD FOR INERTING ACTIVATED CARBON IN BIOGAS PURIFICATION EQUIPMENT

CALGON CARBON CORPORATION...

1. A method for purifying a raw biogas, the method comprising:providing an adsorber unit containing a sorbent material;
contacting the sorbent material contained within the adsorber unit with the raw biogas to adsorb organic impurities and/or H2S and thereby form an effluent and a saturated sorbent material, wherein the raw biogas comprises (i) 25-38 vol.% CO2, (ii) methane, and (iii) organic impurities and/or H2S;
separating CO2 from the effluent, the separated CO2 forming a flushing gas;
flushing the saturated sorbent material with the flushing gas to produce a flushed sorbent;
contacting the flushed sorbent with the raw biogas; and
producing a purified biogas from the effluent.

US Pat. No. 10,597,340

SYNTHESIS OF FLUORINATED RADIOPHARMACEUTICALS VIA ELECTROCHEMICAL FLUORINATION

THE REGENTS OF THE UNIVER...

1. A method of forming an [18F] aryl fluoride compound, the method comprising a step of:contacting an [18F] fluoride source with an aryl compound comprising a reactive aryl carbon covalently bound to an electron donating leaving group within an electrochemical mixture comprising a solvent and an electrolyte; and
allowing said [18F] fluoride source to react with said reactive aryl ring carbon in the presence of an applied electrical current thereby forming said [18F]aryl fluoride compound; wherein said [18F]aryl fluoride compound is of formula (I):

wherein,
z is an integer from 0 to 10;
L1 is independently —O—, —NH—, —S—, —C(O)NH—, —NHC(O)—, —NHNH—, —S(O)—, —S(O)2—, —ONH—, or —NHO—;
R1 is independently hydrogen, halogen, —N3, —CF3, —CCl3, —CBr3, —CI3, —CN, —C(O)R3A, —OR3A, —NR3AR3B, —C(O)OR3, —CONR3AR3B, —NR3AR3BC(O)R3C, —NO2, —SR3A, —SO2, —SO2Cl, —SO3R3A, —SO2NR3AR3B, —NHNR3AR3B, —ONR3AR3B, —NHC(O)NHR3AR3B, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
R3A, R3B and R3C are independently hydrogen, halogen, —N3, —CF3, —CCl3, —CBr3, —CI3, —CN, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; and
two R1 subsitutents are optionally joined to from a substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
wherein said [18F] aryl fluoride compound has a specific activity of more than 15 GBq/?mol; and
wherein the electrolyte is tetrabutylammonium perchlorate (NBu4ClO4) or tetrabutylammonium hexafluorophosphate (NBu4PF6).

US Pat. No. 10,597,338

LIQUID FORMULATIONS OF UREASE INHIBITORS FOR FERTILIZERS

20. A fertilizer composition comprisinga. granular urea,
b. one or more phosphoramides, wherein the one or more phosphoramides comprise N-(n-butyl) thiophosphoric triamide,
c. one or more aprotic solvents wherein said one or more aprotic solvents comprise dimethyl sulfoxide,
d. polyethylene glycols, and
e. optionally one or more members selected from the group consisting of i) urea formaldehyde polymers and ii) dicyandiamide,
wherein the compositional weight percent of N-(n-butyl) thiophosphoric triamide comprises 5-75% relative to the dimethyl sulfoxide and polyethylene glycols.

US Pat. No. 10,597,337

PROCESS FOR MAKING A FULLY WATER-SOLUBLE GRANULE COMPRISING HUMIC ACID AND A MICROBIAL COMMUNITY COMPOSITION

1. A process for making a fully water-soluble granule comprising humic acid and a microbial community composition, the process comprising:obtaining a sample of a carbonaceous substance comprising humic acid and one or more other substances;
contacting the sample with an amount of an alkaline mixture, thereby forming an extraction mixture, the extraction mixture consisting essentially of a sludge component, the sludge component comprising, predominantly, the sample, and an extraction component, the extraction component comprising, predominantly, the alkaline mixture;
maintaining the sludge component in contact with the extraction component for a period of time sufficient for the extraction component to become relatively enriched in humic acid and the sludge component to become relatively depleted of humic acid;
separating the sludge component from the extraction component;
spray drying the extraction component, thereby forming a plurality of humic acid enriched powder particles;
combining a microbial community composition to the plurality of humic acid enriched powder particles, thereby forming a powder combination,
wherein the powder combination has a ratio of about 1:100 to 1:50 microbial community composition to the plurality of humic acid enriched powder particles; and
compacting at least a portion of the powder combination under conditions wherein the at least a portion of the powder combination, as a result of the compacting, are made into a form of a granule;
thereby making a fully water-soluble granule comprising humic acid and a microbial community composition.

US Pat. No. 10,597,336

POROUS CERAMIC STRUCTURE

NGK Insulators, Ltd., Na...

1. A porous ceramic structure having a porosity of 20% to 99%, comprising one principal surface, and another principal surface opposite to the one principal surface, wherein at least one cut is formed from the one principal surface toward the other principal surface, wherein a depth of the cut is less than a thickness of the porous ceramic structure, and an aspect ratio of a portion divided by the cut is greater than or equal to 3, wherein a thermal conductivity of the porous ceramic structure is less than or equal to 1 W/mK, and wherein the porous ceramic structure has a structure in which fine grains are connected in three dimensions, and a grain diameter of the fine grains is 1 nm to 5 ?m.

US Pat. No. 10,597,333

PROCESS FOR PRODUCING CERAMIC FIBER-REINFORCED COMPOSITE MATERIAL

JAPAN AEROSPACE EXPLORATI...

1. A process for producing a ceramic fiber-reinforced composite material that is formed by infiltrating the entirety or a part of pores that are present in a composite material substrate obtained by forming ceramic fibers into a composite with a matrix formed of an inorganic substance, with an infiltrating material,wherein the composite material substrate consists of silicon carbide fibers having an amorphous structure, and free carbon that is present in the entirety or a part of pores that are present in the amorphous structure, and
the infiltrating material is an alloy having a composition that is constituted by a disilicide of at least one or more transition metal among transition metals selected from scandium, yttrium, titanium, zirconium, hafnium, and tantalum, and silicon as the remainder, has a silicon content ratio, including the silicon in the transition metal disilicide, of 66.7 at % or more and less than 90.0 at % and gives a melting point that is lower than that of a single body of silicon, and
the process consists of melt-infiltrating the pores that are present in the composite material substrate with the infiltrating material at a temperature that is equal to or more than the melting point of the alloy as the infiltrating material and that is less than 1,400° C.,
wherein the alloy as the infiltrating material reacts with the free carbon in the pores during the melt infiltration to generate silicon carbide and a carbide of the transition metal.

US Pat. No. 10,597,330

THERMAL BARRIER COATING FOR CMAS RESISTANCE AND LOW THERMAL CONDUCTIVITY

United Technologies Corpo...

1. A part comprising:a substrate;
a bond coat on said substrate;
a ceramic layer on said bond coat;
a first thermal barrier coating layer on said ceramic layer, said first thermal barrier coating layer consisting of neodymia, alumina, and the balance zirconia wherein said first thermal barrier coating layer consists of from 15-60 mol % neodymia, 2.0-40 mol % alumina, and the balance zirconia; and
a second thermal barrier coating layer which consists of an oxide stabilized zirconia and 25 to 99.9 wt % gadolinia.

US Pat. No. 10,597,329

THERMAL BARRIER COATING FOR CMAS RESISTANCE AND LOW THERMAL CONDUCTIVITY

United Technologies Corpo...

1. A thermal barrier coating system comprising:a substrate;
a bond coat on said substrate;
a ceramic layer on said bond coat;
a first thermal barrier coating layer on said ceramic layer, said first thermal barrier coating layer consisting of neodymia, alumina, and the balance zirconia wherein said first thermal barrier coating layer consists of from 15-60 mol % neodymia, 2.0-40 mol % alumina, and the balance zirconia; and
a second thermal barrier coating layer which consists of an oxide stabilized zirconia and 25 to 99.9 wt % gadolinia.

US Pat. No. 10,597,321

EDGE CHAMFERING METHODS

Corning Incorporated, Co...

21. A method of chamfering a material comprising:focusing a pulsed laser beam into a laser beam focal line, viewed along the beam propagation direction; and
laser drilling a plurality of defect lines along each of N planes within the material by, for each of the N planes:
directing the laser beam focal line into the material at a corresponding angle of incidence to the material, the laser beam focal line generating an induced absorption within the material, the induced absorption producing a defect line along the laser beam focal line within the material; and
translating the material and the laser beam relative to each other, thereby laser drilling the plurality of defect lines along the corresponding plane of the N planes; and
separating the material along at least one of said N planes by applying an ion-exchange process to the material.

US Pat. No. 10,597,320

BENDING TOOL FOR GLASS PANES

SAINT-GOBAIN GLASS FRANCE...

1. A method for bending at least one glass pane with a bending tool,the bending tool comprising:
a frame-like, convex contact surface; and
a cover having a peripheral air guide plate that surrounds the convex contact surface at least in regions, the bending tool constructed and arranged to contact a peripheral portion of a main surface of the glass pane such that a majority of the main surface of the glass pane is without contact with the bending tool during bending of the glass pane by the bending tool,
the method comprising:
heating the glass pane to a bending temperature;
bringing the glass pane in contact with the convex contact surface such that the convex contact surface contacts said peripheral portion of the main surface of the glass pane, the majority of the main surface of the glass pane being without contact with the bending tool;
generating a first, reduced pressure in a first region between the peripheral air guide plate and the convex contact surface, thereby suctioning air at an edge of the glass plane;
generating a second, reduced pressure in a second pressure region, wherein the second pressure is less than the first pressure;
generating a third pressure in a third pressure region, wherein the third pressure is greater than the first pressure; and
bending the glass pane through differences in pressure.

US Pat. No. 10,597,319

METHOD FOR MANAGING AIR STREAMS FROM MECHANICAL DEHYDRATION OF SLUDGE, AND CORRESPONDING DEVICE

SUEZ INTERNATIONAL, Pari...

1. A piston press (1), comprising:a pressing chamber (2), formed by a cylinder (21) and a piston (22), the pressing chamber (2) also including drains (32a) connecting the piston (22) and a first end of the cylinder (211), and a recovery chamber (32b) located in the first end of the cylinder (211) and connected to a mixed part pipe element (34a), the drains (32a) being impermeable to solid materials and permeable to liquids and gases;
a pipe (3) connecting the pressing chamber (2) to an air outlet (31); and
closure means (61, 62) for reversibly closing the pipe (3) to reversibly prevent any circulation of air or water in the pipe (3),
said piston press (1) being arranged in order to carry out at least one pressing operation (A2), comprising:
at least one first displacement of the piston in a first direction (11) that reduces the volume of the pressing chamber (2), and
at least one second displacement of the piston in a second direction (12) that increases the volume of the pressing chamber (2),
said pipe (3) being arranged so that air circulating in the pipe (3) between the pressing chamber (2) and said air outlet (31) is displaced:
from the pressing chamber (2) to the air outlet (31) of the pipe (3) when the piston (22) is displaced in the first direction (11), and
to the pressing chamber (2) when the piston (22) is displaced in the second direction (12),
the pipe (3) comprising:
a mixed part (34a) arranged to move air and water originating from the pressing chamber (2), and
a bifurcation (33a) arranged in order to separate the air and the water moved through the mixed part (34a),
the mixed part (34a) of the pipe (3) connected to the recovery chamber and located between the bifurcation (33a) and the pressing chamber (2).

US Pat. No. 10,597,317

SYSTEMS FOR CREATING AN OXIDATION REDUCTION POTENTIAL (ORP) IN WATER FOR PATHOGENIC CLEANSING AND/OR DEGREASING OF HARD SURFACES AND EQUIPMENT

10. A system for creating an oxidation reduction potential (ORP) in water for the pathogenic cleansing of equipment, comprising:an ozone generator configured to generate ozone with said ozone generator having an air inlet side and an ozone outlet side;
an electrically driven air pump having an air discharge side;
an air dryer having an air intake side and an air discharge side;
said air discharge side of said air pump being connected to said air intake side of said air dryer for supplying pressurized air to said air dryer;
said air discharge side of said air dryer being connected to said air inlet side of said ozone generator;
a regulator having an elongated body with a first end, a second end, a front side, a back side, an upper side and a lower side;
said first end of said regulator having a water inlet opening extending thereinto;
said water inlet opening having inner and outer ends;
said water inlet opening of said regulator being in communication with a source of water;
said second end of said regulator having a water-ozone solution discharge opening extending thereinto;
said water-ozone solution discharge opening having inner and outer ends;
said elongated body having a body portion, with first and second ends, positioned between said inner end of said water inlet opening and said inner end of said water-ozone solution discharge opening;
said body portion having a venturi chamber, with first and second ends, formed therein between said first and second ends of said body portion;
said body portion having a first elongated bore, having inner and outer ends, formed therein which extends from said first end of said body portion to said venturi chamber;
said body portion having an elongated second bore, having inner and outer ends, formed therein which extends from said venturi chamber to said inner end of said water-ozone solution discharge opening;
an ozone adjustment housing secured to said body of said regulator at said front side of said elongated body of said regulator;
said ozone adjustment housing having an inner end, an outer end, an upper side, a lower side, a first side and a second side;
said ozone adjustment housing having an ozone passageway formed therein extending between said outer and inner ends of said ozone adjustment housing;
said outer end of said ozone passageway being in communication with said ozone outlet side of said ozone generator whereby ozone produced by said ozone generator will pass inwardly through said ozone passageway in said ozone adjustment housing;
said ozone adjustment housing having an ozone metering adjustment screw which threadably extends inwardly into said ozone adjustment housing through said side wall of said ozone adjustment housing into said ozone passageway in said ozone adjustment housing for adjustably regulating the flow of ozone therethrough;
said body portion having an elongated third bore formed therein which extends between said first end of said body portion to said second end of said body portion whereby a portion of water being supplied to said water inlet opening of said regulator will pass through said elongated third bore and whereby a portion of water being supplied to said water inlet opening will pass through said elongated first bore to said venturi chamber and pass through said elongated second bore to said water-ozone solution discharge opening;
said upper side of said elongated body of said regulator having a vertically disposed opening formed therein which has an upper end and a lower end;
said lower end of said vertically disposed opening being in communication with said elongated third bore;
a vertically adjustable water metering screw, having upper and lower ends, positioned in said vertically disposed opening;
said lower end of said water metering screw being vertically adjustable movable into said elongated third bore to adjust the flow of water through said elongated third bore; and
said water passing through said venturi chamber creating a venturi effect which sucks or draws ozone from said ozone passageway of said ozone adjustment housing which is mixed with the water passing through said venturi chamber into said elongated second bore and to be further mixed with the water passing outwardly from said elongated third bore into said water-ozone solution discharge opening and thence outwardly from said second end of said regulator.

US Pat. No. 10,597,316

SYSTEM FOR IMPLEMENTATION OR DE-POLLUTION AND REVITALIZATION OF ARTIFICIAL OR NATURAL LAKES

DT ENGENHARIA DE EMPREEND...

1. A system for implementation or de-pollution and revitalization of artificial or natural lakes, wherein the system is provided with modulation in the artificial or natural lakes, by means of insertion of dividing walls made of vinyl curtain, land dykes, concrete walls, or any waterproof material, dividing the artificial or natural lake in isolated places, said system comprising said dividing walls, which form modules, said dividing walls being fixed to bottom of the artificial or natural lake without leaving any gaps or openings, and said dividing walls are above water level of said lake, so there is no contact between water of each module, wherein each module can be used for different activities of at least, one of bathing, water sports, fishing, wherein water of the artificial or natural lake is de-polluted through a mobile treatment unit conditioned into containers.

US Pat. No. 10,597,315

METHOD OF DISINFECTION OF DRINKING WATER USING OZONE AND SILVER CATIONS

KAUNAS UNIVERSITY OF TECH...

1. A method of disinfecting drinking water comprising ozonizing the drinking water and treatment of the drinking water with silver ions, wherein said method comprises:a) ozonizing the drinking water until the concentration of ozone in the drinking water becomes 0.1-0.5 mg/L,
b) maintaining said ozonized drinking water for up to 60 minutes and treating the ozonized drinking water with a stable solution consisting essentially of dissolved silver ions and at least one of, alkaline earth and alkaline metal salts, by supplying such amount of said stable solution to the said ozonized drinking water, so that the silver ion concentration in drinking water would be from 0.02 to 0.1 mg/L;
wherein the solution is prepared by dissolving metallic silver in the presence of a high concentration of at least one of alkaline earth or alkaline metal salts;
wherein the silver cations are derived not by way of electrolysis prior to water treatment and wherein the at least one of, alkaline earth and alkaline metal salts of the stable solution is configured to convert silver ions into insoluble compounds in the ozonized drinking water.

US Pat. No. 10,597,314

FATTY ACID BIODISPERSANT AND METHODS OF USE

GENERAL ELECTRIC COMPANY,...

1. A biodispersant composition comprising at least one unsaturated fatty acid (“FA”), said FA having a polar head group on a terminal end, said polar head group comprising a carboxylic acid, and wherein the biodispersant composition further comprises water and at least one emulsifier selected from an ethoxylated surfactant, alkyl alcohols, carboxylic acids, and combinations thereof, wherein the at least one emulsifier comprises about 0.5% to about 30% by weight of a total weight of the biodispersant composition, and wherein the biodispersant composition comprises a water-in-oil emulsion,wherein at least one FA is selected from the group consisting of (Z)-tetradec-9-enoic acid, hexadec-9-enoic acid, (Z)-6-hexadecenoic acid, (9Z,11E,13E)-octadeca-9,11,13-trienoic acid, (9Z)-octadec-9-enoic acid, (E)-octadec-9-enoic acid, (E)-octadec-11-enoic acid, (9Z,12Z)-9,12-octadecadienoic acid, (9E,12E)-octadeca-9,12-dienoic acid, (9Z,12Z,15Z)-9,12,15-octadecatrienoic acid, (5Z,8Z,11Z,14Z)-5,8,11,14-eicosatetraenoic acid, (5Z,8Z,11Z,14Z,17Z)-5, 8,11,14,17-icosapentaenoic acid, (Z)-docos-13-enoic acid, (4Z,7Z,10Z,13Z,16Z,19Z)-docosa-4,7,10,13,16,19-hexaenoic acid, and combinations thereof.

US Pat. No. 10,597,313

CHLORINATION-ASSISTED COAGULATION PROCESSES FOR WATER PURIFICATION

Saudi Arabian Oil Company...

1. A process for treating an aqueous composition, the process comprising:converting at least a portion of chloride ions in the aqueous composition to hypochlorite ions or hypochlorous acid by passing an electric current through at least a portion of the aqueous composition under anaerobic conditions, the aqueous composition including the chloride ions, iron (II) compounds, and one or more organic compounds;
reacting at least a portion of the iron (II) compounds of the aqueous composition with the hypochlorite or hypochlorous acid to produce iron (III) ions; and
coagulating the one or more organic compounds with the iron (III) ions to produce a plurality of insoluble solid particles in a treated aqueous composition.

US Pat. No. 10,597,312

METHODS OF REMOVING PERCHLORATE FROM WATER AND VESSELS AND SYSTEMS FOR PRACTICING THE SAME

The Regents of the Univer...

1. A method of removing perchlorate from water, comprising:contacting water containing perchlorate with a cationic material, wherein the cationic material comprises:
a plurality of silver ions and a plurality of nitrate ions connected into an extended structure by 4,4? bipyridine,
to remove perchlorate from the water.

US Pat. No. 10,597,309

COUPLING PHOTOVOLTAIC, CONCENTRATED SOLAR POWER, AND WIND TECHNOLOGIES FOR DESALINATION

Saudi Arabian Oil Company...

1. A land-based desalination system for desalination of salt water, the desalination system comprising:a concentrated solar power (CSP) system, where the CSP system includes a solar trough field, where the CSP system concentrates solar energy to increase temperature and pressure of a heat transfer fluid and produces steam from a steam water supply utilizing heat from the heat transfer fluid, where an area of the solar trough field exceeds about 700,000 sq. meters, where thermal energy output from the solar trough field exceeds about 240 thermal megawatts, and where the CSP system utilizes CSP technology selected from the group consisting of: a parabolic trough, a Fresnel trough, a tower central receiver, a tower distributed receiver, and combinations thereof to produce steam;
a desalination unit in fluid communication with the CSP system, where the desalination unit produces desalinated water from a salt water supply utilizing a portion of the total steam produced by the CSP system, and where the desalination unit utilizes desalination technology selected from the group consisting of: multi-stage flashing (MSF), multiple effect distillation (MED), and combinations thereof; and
a pump station in fluid communication with the CSP system and the desalination unit, where the pump station receives the desalinated water from the desalination unit, where the pump station includes a turbine driven pump and transmits the desalinated water to consumers by driving the turbine driven pump utilizing a remaining portion of the total steam produced by the CSP system, the remaining portion of the steam sufficient to drive the turbine driven pump,
where the desalination system is a stand-alone system and operates to produce desalinated water independent of an external electrical grid.

US Pat. No. 10,597,304

SURFACE-MODIFIED CYANIDE-BASED TRANSITION METAL COMPOUNDS

Natron Energy, Inc., San...

1. A material, comprising:at least one composition represented by Formula II: AxMn(y-k)Mjk[Mnm(CN)(6-p-q)(NC)p(Che_I)rq]z. CHE_GROUP (Vac)(1-z).nH2O,
wherein CHE_GROUP includes one or more chelation materials selected from the group consisting of (Che_I)rw, (Che_II)sv, wherein Che_I includes a first chelation species and Che_II includes a second chelation species, said second chelation species including one or more chemical species selected from the group including a first material including said first chelation species, a second material excluding said first chelation species, and combinations thereof;
wherein, in Formula II, each A is an independently selected alkali metal Li, Na, or K; and each dopant M may optionally be at least one independently selected alkaline earth metal Mg or Ca, post-transition metal Al, Ga, In, Sn, or Pb, or transition metal Sc, Ti, V, Cr, Fe, Co, Ni, Cu, Zn, Pd, Ag, or Cd having an average valence j; and Che represents an acid chelating agent which includes ligand binding atoms that form one or more covalent linkages with Mn or with Mn and M; and
wherein 0 wherein x+2(y?k)+jk+(m+(r+1)q?6)z+wr+vs=0; and
wherein Formula II includes one or more Mn(CN)(6-p-q)(NC)p(Che_I)rq complexes each including an Mn atom, and wherein p is an average number of NC groups found in said one or more Mn(CN)(6-p-q)(NC)p(Che_I)rq complexes; and wherein q is an average number of Che_I groups found in said one or more Mn(CN)(6-p-q)(NC)p(Che_I)rq complexes; and
wherein m is an average valence of said Mn atoms found in said one or more Mn(CN)(6-p-q)(NC)p(Che_I)rq complexes;
wherein (Vac) identifies a Mn(CN)(6-p-q)(NC)p(Che_I)rq vacancy;
wherein CN identifies a cyano group; and
wherein NC identifies an isocyano group.

US Pat. No. 10,597,303

SURFACE-MODIFIED CYANIDE-BASED TRANSITION METAL COMPOUNDS

Natron Energy, Inc., San...

1. An electrochemical cell, comprising:an anode;
a cathode; and
an electrolyte;
wherein said anode includes a current collector having a surface; and
a composite coupled to said surface, said composite including an electrochemically active material having a composition, a binder, and an electrically conductive material, wherein said composition comprises at least one composition represented by Formula II:
AxMn(y-k)Mjk[Mnm(CN)(6-p-q)(NC)p(Che_I)rq]z.CHE_GROUP (Vac)(1-z).nH2O, wherein CHE_GROUP includes one or more chelation materials selected from the group consisting of (Che_I)rw, (Che_II)sv, wherein Che_I includes a first chelation species and Che_II includes a second chelation species, said second chelation species including one or more chemical species selected from the group including a first material including said first chelation species, a second material excluding said first chelation species, and combinations thereof;
wherein, in Formula II, each A is an independently selected alkali metal Li, Na, or K; and each dopant M may optionally be at least one independently selected alkaline earth metal Mg or Ca, post-transition metal Al, Ga, In, Sn, or Pb, or transition metal Sc, Ti, V, Cr, Fe, Co, Ni, Cu, Zn, Pd, Ag, or Cd having an average valence j; and Che represents an acid chelating agent which includes ligand binding atoms that form one or more covalent linkages with Mn or with Mn and M; and
wherein 0 wherein x+2(y?k)+jk+(m+(r+1)q?6)z+wr+vs=0; and
wherein Formula II includes one or more Mn(CN)(6-p-q)(NC)p(Che_I)rq complexes each including an Mn atom, and wherein p is an average number of NC groups found in said one or more Mn(CN)(6-p-q)(NC)p(Che_I)rq complexes; and
wherein q is an average number of Che_I groups found in said one or more Mn(CN)(6-p-q)(NC)p(Che_I)rq complexes; and
wherein m is an average valence of said Mn atoms found in said one or more Mn(CN)(6-p-q)(NC)p(Che_I)rq complexes;
wherein (Vac) identifies a Mn(CN)(6-p-q)(NC)p(Che_I)rq vacancy;
wherein CN identifies a cyano group; and
wherein NC identifies an isocyano group.

US Pat. No. 10,597,301

AMMONIA PRODUCTION METHOD

JGC CORPORATION, Yokoham...

1. A high-concentration ammonia production method, comprising:subjecting a resultant generation gas to treatment using an ammonia separation membrane or an ammonia PSA to separate the generation gas into high-concentration ammonia and a residual gas;
recycling the residual gas as a nitrogen gas raw material of an ammonia synthesis reactor, and liquefying the high-concentration ammonia recovered through the ammonia separation membrane or the ammonia PSA; and
subjecting an unliquefied gas separated from liquefied ammonia to the treatment using the ammonia separation membrane or the ammonia PSA again.

US Pat. No. 10,597,300

EMM-28, A NOVEL SYNTHETIC CRYSTALLINE MATERIAL, ITS PREPARATION AND USE

EXXONMOBIL RESEARCH AND E...

1. An organic nitrogen compound comprising a dication of formula I, II and III:

US Pat. No. 10,597,299

SYNTHESIS OF ITE FRAMEWORK TYPE MOLECULAR SIEVES

Chevron U.S.A. Inc., San...

1. A method of synthesizing a molecular sieve of ITE framework type, the method comprising:(a) providing a reaction mixture comprising:
(1) a source of silicon oxide;
(2) a source of an oxide of a trivalent element (X);
(3) a structure directing agent (Q) comprising one or more of 1-ethyl-1,3,5-trimethylpiperidinium cations and 1-ethyl-1-methyldecahydroquinolinium cations; and
(4) water; and
(b) subjecting the reaction mixture to crystallization conditions sufficient to form crystals of the molecular sieve.

US Pat. No. 10,597,298

CERAMIC ENCAPSULATION BY USE OF ONE OR MORE SPECIALIZED SILANES TO TEMPLATE OIL IN AN OIL IN WATER EMULSION

CoLabs International Corp...

1. A method for forming silica-based particles, the method comprising the steps:(a) preparing an emulsion having a basic pH, the emulsion including a continuous phase that is polar and has one or more nonionic surfactants and/or one or more anionic surfactants, and a dispersed phase comprising droplets including a non-polar active ingredient and a non-polar diluent;
(b) adding a first modified silica precursor to the emulsion such that the first modified silica precursor is emulsion templated onto the surface of the droplets to form a silica-based first shell layer around the droplets, wherein the first shell layer formed has a mean thickness of about 1 nm to about 500 nm within 2 hours from addition of the first modified silica precursor to the emulsion, and wherein the first modified silica precursor has the general formula (I):
R1x-Si-(OR2)y  (I)wherein R1 is selected from substituted and unsubstituted alkyl, aryl, alcohols, amines, amides, aldehydes, acids, esters, and functional groups having an unsaturated carbon-carbon bond, wherein R2 is an alkyl group, wherein x+y=4, and wherein x=1 or 2;(c) adding a second modified silica precursor to the emulsion such that a coating can be deposited on at least part of the silica-based first shell layer through the interaction of the second modified silica precursor with the first modified silica precursor present in the silica-based first shell layer to form a second shell layer, wherein the first silica precursor and the second silica precursor are different; and
(d) allowing the emulsion to sit for up to 2 days until the thickness of the first shell layer and the second shell layer together have a mean thickness in the range of about 1 ?m to about 250 ?m;
wherein the method produces silica-based particles having a silica-based shell surrounding a liquid core comprising the non-polar active ingredient and the non-polar diluent.

US Pat. No. 10,597,297

ENRICHED ACID GAS FOR SULFUR RECOVERY

Saudi Arabian Oil Company...

1. A system of acid gas enrichment, the system comprising:an acid gas stream connector configured to receive an acid gas stream;
a contactor configured to separate the acid gas stream received from the acid gas stream connector into a carbon dioxide rich stream and a purified acid gas stream, the acid gas stream comprising hydrogen sulfide (H2S), carbon dioxide (CO2), and hydrocarbons;
a regenerator in fluid communication with the contactor such that the regenerator is configured to separate the purified acid gas stream to obtain a hydrogen sulfide rich stream and a hydrogen sulfide lean stream, the hydrogen sulfide rich stream having a concentration of hydrogen sulfide;
a recycle stream conduit fluidly coupled between the regenerator and the contactor, and configured to supply at least a portion of the hydrogen sulfide rich stream from the regenerator to the contactor; and
an acid gas recycle valve coupled to the recycle stream conduit that opens and closes a fluid pathway from the regenerator to the contactor based on an H2S content in the hydrogen sulfide rich stream to direct the hydrogen sulfide rich stream exiting the regenerator to combine with the acid gas stream at the acid gas stream connector prior to the combination of the hydrogen sulfide rich stream and the acid gas stream entering the contactor.

US Pat. No. 10,597,294

INTEGRATED METHODS FOR CHEMICAL SYNTHESIS

Novomer, Inc., Rochester...

1. A method for the integrated production of chemicals comprising:a) in a first reaction zone, contacting an epoxide in the presence of a carbonylation catalyst with a syngas stream containing hydrogen and carbon monoxide to produce an epoxide carbonylation product, and
b) removing an upgraded gas stream from the first reaction zone, wherein the upgraded gas stream has a higher hydrogen to carbon monoxide ratio than the starting syngas stream.

US Pat. No. 10,597,293

OPERATION METHOD FOR HYDROGEN PRODUCTION APPARATUS, AND HYDROGEN PRODUCTION APPARATUS

Osaka Gas Co., Ltd., Osa...

1. A hydrogen production apparatus comprising a desulfurizer that desulfurizes a source gas, a reformer that heats the desulfurized source gas in a state mixed with steam with a heater and obtains a reformed gas, a CO transformer that causes carbon monoxide in the reformed gas to react with steam and obtains a transformed gas, and a hydrogen purification unit that separates impurities other than hydrogen from the transformed gas after processing by the CO transformer to purify hydrogen gas, further comprising:a gas flow path that allows gas comprising at least one of the source gas, the desulfurized source gas, the reformed gas, the transformed gas, and/or the hydrogen gas to flow to the desulfurizer, the reformer, the CO transformer, and/or the hydrogen purification unit, and a pressure feed configured to cause the gas to flow in the gas flow path,
a controller programmed or configured to perform, in order, a hydrogen purification operation for driving the heater and the pressure feed to supply the gas to the gas flow path, and a stopping operation configured to stop operation of the heater and the pressure feed, and
a throttle unit in a return path that returns and circulates the gas while bypassing the hydrogen purification unit in a closed circulation circuit, the throttle unit configured to switch between a throttled state in which a first flow path resistance is set and a throttle released state in which a second flow path resistance is set, wherein the second flow path resistance is smaller than the first flow path resistance,
wherein the closed circulation circuit that returns and circulates the gas by the pressure feed in an order of the desulfurizer, the reformer, and then the CO transformer while bypassing the hydrogen purification unit, is provided in the gas flow path, and a purge gas supply path is provided where a purge gas is supplied to an upstream side of the pressure feed in the gas flow path,
wherein the controller, prior to the stopping operation, is programmed or configured to perform a purging step of replacing the gas within the gas flow path with the purge gas, and filling the purge gas into the gas flow path,
wherein the controller, in a start-up operation in which the heater is operated to increase the temperature of the gas within the gas flow path, which is performed prior to the hydrogen purification operation, is programmed or configured to perform a pressure increasing step of supplying the purge gas from the purge gas supply path to the closed circulation circuit, and increasing the pressure within the closed circulation circuit while operating the pressure feed, and subsequently to perform a temperature increasing step for operating the pressure feed and the heater and increasing the temperature, and
wherein the controller is programmed or configured to perform the pressure increasing step with the throttle unit switched to the throttled state, and to perform the temperature increasing step with the throttle unit switched to the throttle released state.

US Pat. No. 10,597,290

PROCESS FOR FILLING ETCHED HOLES USING FIRST AND SECOND POLYMERS

Memjet Technology Limited...

1. A process for filling one or more etched holes defined in a frontside surface of a wafer substrate, the process comprising the steps of:(i) depositing a layer of a thermoplastic first polymer onto the frontside surface and into each hole;
(ii) optionally reflowing the first polymer;
(iii) optionally repeating steps (i) and (ii) until the holes are overfilled with the first polymer;
(iv) depositing a layer of a photoimageable second polymer;
(vi) selectively removing the second polymer from regions outside a periphery of the holes, the selective removing comprising exposure and development of the second polymer;
(vii) exposing the wafer substrate to a controlled oxidative plasma so as to reveal the frontside surface of the wafer substrate; and
(viii) planarizing the frontside surface to provide one or more holes filled with a plug comprising the first polymer only, each plug having a respective upper surface coplanar with the frontside surface,
wherein the first polymer is less viscous than the second polymer.

US Pat. No. 10,597,288

MEMS-DEVICE MANUFACTURING METHOD, MEMS DEVICE, AND MEMS MODULE

ROHM CO., LTD., Kyoto (J...

1. A MEMS device characterized in that the MEMS device includes:a substrate that has a movable portion and a hollow portion both of which coincide with each other when viewed in a thickness direction and a fixed portion that supports the movable portion, and characterized in that the movable portion and the fixed portion are made of a same and single semiconductor that does not have a joined portion at a boundary between the movable portion and the fixed portion;
a first metallic layer formed on the substrate, the first metallic layer having a pad portion, and an outer peripheral portion that is physically separated from the pad portion and that surrounds the pad portion; and
a second metallic layer covering the pad portion and the outer peripheral portion together, and having a portion that enters a first region between the pad portion and the outer peripheral portion, wherein
the substrate has a principal surface including a surface of the movable portion, and the principal surface has a concave portion that coincides with the movable portion when viewed in the thickness direction, and
the outer peripheral portion is electrically connected to the pad portion through the second metallic layer.

US Pat. No. 10,597,287

MULTI-CHAMBER TRANSDUCER MODULE, APPARATUS INCLUDING THE MULTI-CHAMBER TRANSDUCER MODULE AND METHOD OF MANUFACTURING THE MULTI-CHAMBER TRANSDUCER MODULE

STMICROELECTRONICS S.R.L....

1. A transducer module, comprising:a supporting substrate having a first side and a second side, first and second through vias extending from the first side to the second side;
a conductive path at the second side of the supporting substrate, the conductive path coupled to the first and second through vias;
a cap coupled to the first side of the supporting substrate to form a first chamber and a second chamber, the second chamber being internally isolated from the first chamber, the first through via being in the supporting substrate at the first chamber, the second through via being in the supporting substrate at the second chamber;
a first sensor chip coupled to the first side of the supporting substrate in the first chamber, the first sensor chip integrating a first microelectromechanical (MEMS) transducer configured to detect a first environmental quantity and to generate a first transduced signal as a function of the first environmental quantity detected;
a second sensor chip coupled to the first side of the supporting substrate in the second chamber, the second sensor chip integrating a second microelectromechanical (MEMS) transducer configured to detect a second environmental quantity and to generate a second transduced signal as a function of the second environmental quantity detected; and
a control chip in the first chamber, the control chip being functionally coupled to the first MEMS transducer, the control chip being functionally coupled to the second MEMS transducers by the first and second through vias and the conductive path.

US Pat. No. 10,597,286

MONOLITHIC PHASE CHANGE HEAT SINK

Analog Devices Global, H...

1. A monolithic microelectromechanical (MEMS) device including a vapor chamber, the device comprising:a condenser substrate;
a device substrate having a device surface comprising an integrated circuit disposed therein and a rear surface, wherein the vapor chamber is enclosed between the condenser substrate and one of the device surface or rear surface of the device substrate, wherein the condenser substrate has approximately a same footprint as the device substrate;
a phase change liquid disposed in the vapor chamber, the phase change liquid being in contact with the device substrate; and
one or more wicks extending into the vapor chamber.

US Pat. No. 10,597,285

DEVICES AND METHODS FOR HEATING FUEL HOSES AND NOZZLES

Wayne Fueling Systems LLC...

1. A fuel dispensing device, comprising:a hose having first and second passageways extending longitudinally therethrough, the first passageway being configured to pass fluid therethrough, the second passageway being adjacent to and independent from the first passageway, and the second passageway being configured to pass air therethrough;
a heat element disposed within and extending along a longitudinal length of the second passageway in the hose, the heat element being configured to heat the air passing through the second passageway, thereby heating the fluid within the first passageway that is adjacent the second passageway;
a nozzle, the first passageway extending through the nozzle such that the fluid is allowed to exit a distal opening of the first passageway to allowing be dispensed from the nozzle, and the second passageway having a distal opening that is proximal to the distal opening of the first passageway, the distal opening of the second passageway allowing the air to pass therethrough;
a flow diverting element located at a junction between the hose and the nozzle, the flow diverting element being configured to divert the first and second passageways such that distal to the flow diverting element in the hose the second passageway is disposed within the first passageway and proximal to the flow diverting element in the nozzle the first passageway is disposed within the second passageway; and
a movable element located distal to the nozzle and proximal to the flow diverting element, the movable element being configured to rotate about a longitudinal axis of the hose so as to allow the nozzle to be selectively oriented relative to the hose, and the first and second passageways extending through the movable element.

US Pat. No. 10,597,283

ERRONEOUS REFUELING PREVENTION DEVICE

YACHIYO INDUSTRY CO., LTD...

1. An erroneous refueling prevention device which restricts or allows insertion of a refueling gun into a refueling passage depending on an outer diameter of the refueling gun,the device comprising:
a flap configured to open or close the refueling passage by a turn of the flap about a first turn pivot; and
a switch configured to be unlocked from the flap by a turn of the flap to a half-opened state, and to turn about a second turn pivot,
wherein the switch comprises a protrusion detector configured to, in response to the turn, project to a position where the protrusion detector faces the refueling passage,
wherein the switch restricts or allows a turn of the flap from the half-opened state to a fully-opened state, depending on a turn amount of the switch to be determined by a contact relationship between the protrusion detector and the refueling gun.

US Pat. No. 10,597,282

MASS BASED LOW PRODUCT INDICATOR

Ecolab USA Inc., Saint P...

1. A dispenser that dispenses a product, the dispenser comprising:a housing comprising a compartment selectively closed and secured by a lockable door, the compartment includes a container holder supporting an opaque product container;
the opaque product container containing a product, the product having a UV sensitivity and a product level within the product container that ranges between full and empty, the product level having a low level wherein the product level is near empty;
a dispensing apparatus associated with the product container to withdraw and dispense product from the product container at an outlet, wherein said dispensing apparatus comprises an outlet tube and a bucket fill assembly for selectively dispensing from either or both of the tube or bucket fill assembly via a dispensing area;
the container holder being vertically moveable within a movement range;
a biasing element supporting the container holder within the housing that urges the container holder upwardly such that a position of the product container in the movement range is dependent upon the product level in the product container; a level indicator window positioned through the lockable door and vertically fixed relative to the housing;
a sign vertically fixed relative to the container holder, the sign including a low level marking at an upper portion of the sign to indicate when the product level is at the low level or lower; and
wherein when the product level is at the low level or lower, the window is aligned with a portion of the low level marking.

US Pat. No. 10,597,281

METHODS AND SYSTEMS TO RECORD THE FLOW OF A LIQUID USING AN ELECTRONIC POURER

1. An inventory system comprising:an electronic pourer, configured to:
transmit a first notification when the electronic pourer is coupled to a container, wherein the first notification includes a unique electronic pourer identification value,
transmit a second notification when it is determined that a pour has occurred through the tamper proof electronic pourer, and
transmit a third notification when the electronic pourer is decoupled from the container; and
a computing device paired with the electronic pourer, configured to:
register the electronic pourer as active upon receiving the first notification, wherein the register includes incrementing a value of a container usage counter, the value of the container usage counter queried from a database coupled to the computing device,
increment a pour counter when it is determined that the electronic pourer has transmitted the second notification,
reset the pour counter when it is determined that the electronic pourer has transmitted the third notification.

US Pat. No. 10,597,279

DRINK HOLDER

CARDIFF GROUP, naamloze v...

10. A holder comprising:a rigid outer holder comprising a mouth; and
an adapter provided on the mouth;
wherein:
the mouth of the rigid outer holder is configured to receive a flexible inner holder that comprises a coupling element, and
the adapter is configured to be coupled to the coupling element of the inner holder,
thereby allowing the inner holder, with the coupling element that is too small to be provided on the mouth directly to be provided on the mouth,
wherein the outer holder and the adapter are fitted with a complementary first lock that locks their relative position when they are coupled, whereby the locking is repeatedly reversible.

US Pat. No. 10,597,278

METHOD OF DISPENSING A BEVERAGE WITH VARIABLE PRESSURE

Anheuser-Busch InBev S.A....

1. A method of preparing and dispensing a beverage with a countertop dispensing device, the device comprising:a housing comprising a beverage unit with a liquid line having a liquid inlet at one end and a beverage outlet at an opposite end; a pressure controller controlling the pressure in the liquid line; and a container receiving means, to receive an ingredient container, such that when correctly installed, the content of the container is in fluid communication with the liquid line for mixing the content of the ingredient container with a base liquid in the liquid line;
an ingredient container identification unit;
a processor coupled to the identification unit and to the pressure controller for controlling said pressure controller based on input received from the container identification;
the method comprising the steps of:
providing the ingredient container in the device;
identifying the ingredient container;
providing a base liquid;
mixing the content of the ingredient container with the base liquid to prepare the beverage to be dispensed;
the thus prepared beverage;
wherein the pressure in the liquid line changes from a first pressure level higher than ambient pressure level, to a second pressure level higher than the ambient level, and higher than the first pressure level, by said pressure controller during dispensing of the beverage, the first pressure level being different from the second pressure level, wherein the pressure is maintained substantially constant at the first level during a first fraction of the period needed for dispensing the beverage, and wherein the pressure is maintained substantially constant at the second level during a second fraction of the period needed for dispensing.

US Pat. No. 10,597,277

FILL VALVE ASSEMBLY FOR FILLER DEVICE AND ASSOCIATED METHOD OF USE

Fogg Filler Company, Hol...

1. A fill valve assembly for use in association with a filler device, comprising:a vent tube, a valve housing, a valve sleeve, and a seal member;
wherein the vent tube comprises an upper venting aperture, a lower venting aperture, an intermediate region having a lower displacement stop member having an annular upper surface, wherein the lower displacement stop member comprises an outer diameter greater than an outer diameter of the vent tube positioned immediately below the lower displacement stop member, and wherein the vent tube is positioned at least partially within the valve housing, and the valve sleeve:
wherein the valve housing is in communication with a filler device;
wherein the valve sleeve is positioned at least partially within the valve housing;
wherein the seal member is positioned within the valve housing;
wherein the fill valve assembly is positionable among a closed position, a first open position, a second open position, and a clean-in-place position;
wherein when the fill valve assembly is in a first open position, the seal member contacts an upper wall of the valve housing, and when the fill valve assembly is in a second open position, the seal member contacts the lower displacement stop member of the vent tube; and
wherein the seal member is configured such that moving the valve sleeve relative to the valve housing causes the seal member to displace upwardly relative to the vent tube and the displacement stop member from the second open position to the first open position.

US Pat. No. 10,597,276

METHOD FOR CONTROLLING A BOTTLER BURST HANDLING PROTOCOL OF A CONTAINER FILLING DEVICE AND A DUMMY CONTAINER APPLIED THEREFOR

Anheuser-Busch InBev S.A....

1. A dummy container for controlling a container filling device comprises:a base;
a housing attached to the base and movable in view of the base between a first extended position and a second collapsed position, the housing defining a fluid inlet extending into a pressure chamber;
a locking mechanism arranged between the housing and the base allowing locking the housing in the first extended position in view of the base; and
actuating mechanism designed to release said locking mechanism between the base and housing upon a pressure increase in the pressure chamber, thereby triggering the movement of the housing into the second collapsed position in view of the base;
the locking mechanism comprises latches which slide laterally from a locked position wherein the latches engage in a recess provided in the base to an unlocked position wherein the latches retract into a recess provided in the actuating mechanism;
the actuating mechanism comprises:
a piston movably arranged in the housing between a first and second position, said piston comprises a piston head sealingly engaging the housing and defining said pressure chamber together with the housing; and
a biasing mechanism for biasing the piston head towards the first position, the biasing mechanism positioned in the housing portion of the dummy and encircling the piston.

US Pat. No. 10,597,275

SOFT ROBOTIC ACTUATORS FOR POSITIONING, PACKAGING, AND ASSEMBLING

Soft Robotics, Inc., Bed...

1. A method comprising:providing a target object to an input location, the input location being proximal to a soft robotic elastomeric actuator, the soft robotic elastomeric actuator comprising an elastomeric body having a reservoir and configured to be inflated by supplying an inflation fluid to the reservoir and further comprising an elastomeric base having a first side forming a gripping surface and a second side exposed to an internal void of the reservoir;
transmitting a first control signal to a controller associated with the soft robotic actuator, the first control signal comprising a first command to inflate the soft robotic actuator;
fixing the target object at the input location using the soft robotic actuator;performing an operation on the target object;determining that the operation has ended;
transmitting a second control signal to the controller, the second control signal comprising a second command to deflate the soft robotic actuator; and
providing the target object to an output location.

US Pat. No. 10,597,273

CARRIER VEHICLE

NIDEC-SHIMPO CORPORATION,...

1. A carrier vehicle comprising:a flat plate through which a through-hole is provided; and
a moving section that causes the flat plate to move,
wherein the moving section is switched among
a reference mode in which the flat plate is caused to move to a reference position,
a penetrating mode in which the through-hole in the flat plate is penetrated through, and
a moving mode in which the flat plate is caused to move from the reference position to a moving position without penetrating through the through-hole in the flat plate.

US Pat. No. 10,597,272

CLAMPING ASSEMBLY FOR LOAD-CARRYING VEHICLE

Loron, Inc., Kelso, WA (...

1. A clamping assembly for a load-carrying vehicle, comprising:first and second clamp arms movable towards and away from each other to contact and exert a clamping force on a load sufficient for lifting and transporting the load;
first clamp arm sensing elements positioned at spaced apart locations on the first clamp arm and responsive to forces exerted at adjacent first clamp arm clamping areas;
second clamp arm sensing elements positioned at spaced apart locations on the second clamp arm and responsive to forces exerted at second clamp arm clamping areas;
wherein the first clamp arm sensing elements and the second clamp arm sensing elements are configured to sense and feed back forces exerted by the first and second clamp arms, respectively, and to passively adjust a clamping force magnitude based on a fraction defined as an engaged clamp arm area engaged by the load divided by a total clamp arm area and a location of the engaged clamp arm area relative to the first clamp arm sensing elements and the second clamp arm sensing elements.

US Pat. No. 10,597,271

PROACTIVELY REDUCING VIBRATIONS IN AN INDUSTRIAL TRUCK

JUNGHEINRICH AKTIENGESELL...

1. An industrial truck, in particular a tri-lateral sideloader, comprising:a truck body;
wheels connected to the truck body by wheel suspensions;
a mast, which extends substantially vertically from the truck body and with which a plurality of attachment parts are associated;
a plurality of operating components, which are designed to carry out operating functions of the industrial truck;
a control unit, which is designed to actuate the plurality of operating components of the industrial truck; and
a detection apparatus, which is designed to detect at least one of an operating parameter of the industrial truck or a parameter of an environment around the industrial truck;
wherein the industrial truck further comprises a prediction unit, which is operationally coupled both to the detection apparatus and the control unit and is designed to predict an occurrence of vibrations on the industrial truck based on data provided by the detection apparatus which represent the at least one of the operating parameter of the industrial truck or the parameter of the environment around the industrial truck;
wherein the industrial truck is designed to provide prediction data to the control unit; and wherein the control unit is further designed, based on the prediction data, to actuate at least one of the plurality of operating components to reduce vibrations associated with the truck body or the mast such that the vibrations predicted by the prediction unit are reduced.

US Pat. No. 10,597,269

LIFT BASE WITH RETRACTABLE WHEELS

SHINN FU COMPANY OF AMERI...

1. A transportable jack system, comprising:a jack disposed on a base, the base comprising:
a base plate having a plurality of wheel openings formed therein; and
a biasing member disposed between a wheel and the base plate;
wherein:
the biasing member comprises configured from a single piece of material consisting of a horizontal top portion, a horizontal bottom portion, and an angled middle portion disposed between the top horizontal portion and the bottom horizontal portion;
the biasing member biases the base plate away from a ground surface when a load applied to the jack is below a predetermined threshold; and
the biasing member deforms when the load is above the predetermined threshold, wherein the deformation allows the base plate to contact the ground surface.

US Pat. No. 10,597,267

VARIABLE RADIUS FAIRLEAD

Hall Labs LLC, Provo, UT...

1. A fairlead comprising:an opening through which a line under tension is rove;
a front lip of the opening comprising a variable radius round;
the front lip guides a change in direction of the line, and
a back lip of the opening comprising a mirror image of the variable radius round.

US Pat. No. 10,597,266

CRANE AND METHOD FOR MONITORING THE OVERLOAD PROTECTION OF SUCH A CRANE

Liebherr-Components Biber...

1. A crane comprising:a boom;
at least one load receiver having a raisable and lowerable configuration;
an overload protection device comprising a detector for detecting the outreach and the load on the at least one load receiver, wherein the overload protection device is configured to compare the detected load and the detected outreach with a stored load curve and to switch off a crane drive when the detected load at the detected outreach equals or exceeds the load curve; and
a monitoring device for monitoring the overload protection device comprising a determiner for determining a tensioning force holding the boom and/or induced in a guy cable;
wherein the monitoring device is configured to:
determine online in crane operation a guying torque from the determined tensioning force present in the guy cable holding the boom,
determine a lifting torque from the detected outreach and the detected load,
determine a dead torque while making use of stored crane data,
compare the sum of the lifting torque and the dead torque with the online determined guying torque, and
then, if a difference of the online determined guying torque from said sum of lifting torque and dead torque exceeds a tolerance threshold, emit an error signal and/or shutdown signal.

US Pat. No. 10,597,265

SLIDER FOR USE WITH A CRANE

High Concrete Group, LLC,...

1. A crane for lifting heavy loads, the crane comprising:a beam having a flange;
a hoist for lifting the loads;
a slider for moving the hoist, the slider comprising;
a hoist support member;
mounting arms extending from either end of the support member, a portion of each mounting arm is spaced from the support member to form a flange receiving slot which is dimensioned to receive the flange of the beam;
a drive mechanism for moving the slider relative to the beam;
wheel mounting members attached to and extending from the mounting arms, each of the wheel mounting members extending from opposite sides of the mounting arms;
wheels extending from the wheel mounting members; and
springs are provided between the wheels and the wheel mounting members, the springs support the weight of the slider without creating contact on the flange of the beam when no load is applied to the slider.

US Pat. No. 10,597,260

ELEVATOR DOOR PANEL

Kone Corporation, Helsin...

1. An elevator door panel, the elevator door panel including a composite material based on reinforcement fibres embedded in a polymer matrix material, the reinforcement fibres being arranged in the polymer matrix material so thatthe elevator door panel is stiff in a vertical plane, and
the elevator door panel is flexible in a horizontal plane such that the elevator door panel is configured to be bent to a curve around a vertical corner,
wherein the elevator door panel is attached to a top roller slider and a bottom roller slider, such that the elevator door panel is configured to be glidingly supported on top and bottom door guide rails via the top and bottom roller sliders, respectively,
wherein the top roller slider includes
a top slider body that is parallel to the top door guide rail,
two top support arms rotatably attached to separate, opposite end portions of the top slider body, each top support arm rotatably attached to the top slider body by a separate articulated joint positioned in a middle of the top support arm, and
a plurality of top rollers, wherein separate top rollers, of the plurality of top rollers, are attached to opposite ends of each top support arm, wherein the separate top rollers that are attached to the opposite ends of each top support arm are configured to be seated within separate U-shaped grooves in the top door guide rail, based on the top roller slider being installed on the top door guide rail,
wherein the bottom roller slider includes
a bottom slider body that is parallel to the bottom door guide rail,
two bottom support arms rotatably attached to separate, opposite end portions of the bottom slider body, each bottom support arm rotatably attached to the bottom slider body by a separate articulated joint positioned in a middle of the bottom support arm, and
a plurality of bottom rollers, wherein separate bottom rollers, of the plurality of bottom rollers, are attached to opposite ends of each bottom support arm, wherein the separate bottom rollers that are attached to the opposite ends of each bottom support arm are configured to be seated within separate U-shaped grooves in the bottom door guide rail, based on the bottom roller slider being installed on the bottom door guide rail.

US Pat. No. 10,597,259

ELEVATOR APPARATUS WITH SEAL MEMBER AND LINK MECHANISM

TOSHIBA ELEVATOR KABUSHIK...

1. An elevator apparatus, comprising:a car-side door sill configured to guide a car door provided in a doorway of an elevator car along its open/close direction;
a landing-side door sill configured to guide a landing door provided in a doorway to the elevator car in each floor where the elevator car can be landed along its open/close direction;
a seal member being displaceable between a sealing position and an evacuation position, the seal member being shaped so as to seal a gap occurring between the car-side door sill and the landing-side door sill, a side of the seal member being rotatably supported by a supporting member at the car-side door sill; and
a link mechanism configured to releasably engage with an actuating member,
wherein the link mechanism is configured to release from engagement with the actuating member at a car side to actuate when the car door starts to open from a door-close end, hold the seal member while rotating the seal member at the sealing position, release the holding of the seal member at the sealing position, and allow the seal member to rotate to the evacuation position,
wherein the link mechanism, when released from the engagement with the actuating member, is configured to move downward by deadweight of component parts and to move upward by the engagement with the actuating member,
wherein a slide block is configured to push down one end of a rotation block to rotate the rotation block to allow the seal member to rotate to the sealing position when the link mechanism moves down,
wherein the slide block is configured to move upward to allow the seal member to rotate to the evacuation position, and
wherein the slide block is configured to move downward to be sandwiched between the rotation block and the car-side door sill, thereby causing the seal member to be held at the sealing position.

US Pat. No. 10,597,257

HIGH SPEED BEARING ASSEMBLY FOR ELEVATOR SAFETY GEAR AND METHODS OF MAKING AND USING SAME

THYSSENKRUPP ELEVATOR AG,...

1. An elevator braking system, comprising:a wedge having a curved wedge bearing race;
a clamping jaw having a curved jaw bearing race; and
a roller bearing assembly; said assembly having two cages with a spacer maintaining a space therebetween; a plurality of rollers rotatably coupled to said two cages; each of said plurality of rollers being barrel shaped; a first side of said roller bearing assembly configured to be coupled to said wedge via said curved wedge bearing race; and, a second side of said roller bearing assembly configured to be coupled to said clamping jaw via said curved jaw bearing race;
wherein said roller bearing assembly further comprises a resetting spring; and
wherein a radius of curvature of each of said plurality of rollers is less than a radius of curvature of said curved wedge bearing race.

US Pat. No. 10,597,256

SAFETY CIRCUIT BOARD FOR A PASSENGER TRANSPORT INSTALLATION

KONE CORPORATION, Helsin...

1. A safety circuit board for controlling an electromechanical brake and motor controller of a passenger transport installation, the safety circuit board comprising:at least one processing unit;
a main safety output with an associated relay connected to the at least one processing unit and providing a connection to the electromechanical brake and motor controller; and
a secondary safety output with an associated relay connected to the at least one processing unit and providing a connection to the electromechanical brake and motor controller,
wherein the main safety output and the secondary safety output are configured in parallel enabling control of the electromechanical brake and motor controller with the at least one processing unit using either of the main safety output and the secondary safety output, and
wherein the at least one processing unit is configured to alternately connect between the main safety output and the secondary safety output when connecting and controlling the electromechanical brake and motor controller.

US Pat. No. 10,597,252

STACKABLE WIRE-DISPENSING CONTAINER

Encore Wire Corporation, ...

1. An apparatus for dispensing wire or cable, the apparatus comprising:a cylindrical enclosure of a first height, wherein the cylindrical enclosure has a bottom portion;
a top portion removably attached to the cylindrical enclosure by a clamping ring;
a wire hole located in both the top and bottom portions of the enclosure; a carrying hole located in both the top and bottom portions of the enclosure; and
a core of a second height located within the enclosure, wherein the core forms an area, wherein the wire hole of both the top and bottom portions of the enclosure is located within the area formed by the core, and wherein the wire or cable is placed around the core and exits the wire hole.

US Pat. No. 10,597,250

ELASTIC HAIR TIE DISPENSER

TIY Products, LLC, Austi...

1. A method for making an elastic hair tie dispenser, comprising the steps of:a) providing two round transparent clamshell housing sections configured to be held together with fasteners, wherein when assembled said two housing sections form a dispenser housing configured to accept a centrally located spool and a cutting blade;
b) providing elastic hair tie cording material removably wound around said spool forming a coil within said assembled dispenser housing; and
c) providing a cording orifice and a cutting slot molded into said dispenser housing; and
d) providing a pivoting blade actuator assembly movably attached to said dispenser housing having a cutting blade therein;
whereby said elastic hair tie cording spooled within said housing is dispensed by being pulled through said cording orifice to a variable desired length then cut with said pivoting blade actuator cutting blade.

US Pat. No. 10,597,249

METHOD AND APPARATUS FOR STACKER MODULE FOR AUTOMATED COMPOSITE-BASED ADDITIVE MANUFACTURING MACHINE

Impossible Objects, Inc.,...

1. A stacker apparatus for stacking and aligning substrate sheets, comprising:a frame having a base plate;
a sheet catcher;
a presser having a press plate and a system that moves the press plate up and down; and
a plurality of registration pins that project upwardly to a location below the sheet catcher, the registration pins having tapers at their upper ends.

US Pat. No. 10,597,247

PRINTING APPARATUS

Canon Kabushiki Kaisha, ...

1. A printing apparatus comprising:a holding unit configured to hold a roll sheet being a continuous sheet wound in a roll form;
a printing unit configured to perform printing on a sheet supplied from the holding unit;
a driving unit configured to perform a conveyance operation to rotate in a first direction to cause the roll sheet held in the holding unit to rotate in a forward direction and convey the sheet to the printing unit;
a first sensor configured to change its output value in accordance with a distance to the sheet of the roll sheet held in the holding unit;
a second sensor located on a conveyance path between the first sensor and the printing unit and configured to detect the sheet during the conveyance operation;
a detecting unit configured to detect a leading end of the sheet on the basis of the output value of the first sensor while causing the roll sheet to rotate in a reverse direction by causing the driving unit to rotate in a second direction opposite to the first direction
a control unit configured to switch a rotation direction of the driving unit from the second direction to the first direction after the detecting unit detects the leading end of the sheet; and
a determining unit configured to determine a conveying state of the conveyed sheet, before the second sensor detects the sheet, on the basis of fluctuation of the output value of the first sensor while the driving unit rotates in the first direction.

US Pat. No. 10,597,244

GUIDING TRAY FOR DOCUMENT CONVEYING APPARATUS

PFU LIMITED, Kahoku-Shi,...

1. A document conveying apparatus comprising:a body;
a document tray having a first document stacking face;
a guiding tray having a second document stacking face, wherein a width of the second document stacking face is smaller than a width of the first document stacking face;
a first support member that movably supports the document tray between an open position where a document is placed on the first document stacking face and a close position where the document tray is closed; and
a second support member that supports the guiding tray,
wherein the second support member positions the guiding tray at a first distance from the document tray, when the document tray is at the open position, wherein
the second support member positions the guiding tray at a second distance from the document tray, when the document tray is at the close position, and wherein the second distance is smaller than the first distance, wherein
the guiding tray includes an engaging member, and wherein
the second support member includes a guide member that engages with the engaging member and movably guides the guiding tray when the document tray moves from the open position to the close position.

US Pat. No. 10,597,243

LOCKING MECHANISM FOR MOVABLE UNIT, AND SHEET FEEDING DEVICE AND IMAGE FORMING APPARATUS PROVIDED THEREWITH

KYOCERA Document Solution...

1. A locking mechanism for a movable unit, comprising:a hook substantially in an L shape, the hook including
a supporting portion pivotably supported on a pivot on a unit main body and
an engaging portion protruding from the supporting portion;
an engaged portion formed on the movable unit supported on, movably relative to, the unit main body, the engaging portion being engageable with the engaged portion; and
a biasing member biasing the hook in a first direction to cause the engaging portion to engage with the engaged portion,
the locking mechanism locking the movable unit to the unit main body,
wherein
the hook has
a first face which is facing the engaged portion at a tip end side of the engaging portion and which is substantially perpendicular to the supporting portion and
a second face extending from the first face toward a supporting portion side and inclined relative to the first face in such a direction as to recede from the pivot, and
when the engaging portion and the engaged portion are in engagement, the engaged portion touches only the second face.

US Pat. No. 10,597,242

SPRING ASSIST ASSEMBLY FOR A LEVELER LIP PLATE

Blue Giant Equipment Corp...

1. A dock leveler comprising:a lip plate that is rotationally attached to an edge of a deck at a hinge and operable between raised and lowered positions, wherein the lowered position is generally parallel with the deck and the raised position is more than 90 degrees from the lowered position; and
a spring assist assembly extending between the deck and the lip plate, the spring assist assembly including a plurality of springs that linearly operate along respective calibrating posts to operate a single linkage member to bias the lip plate toward a vertical position from each of the lowered and raised positions, wherein a base end and a compression end of each spring is adjustable along the respective calibrating posts, and wherein one spring of the plurality of springs is adjusted at the base and compression ends to exert an upward biasing force that biases the lip plate from the lowered position toward the vertical position and also exert an opposing negative biasing force that biases the lip plate from the raised position toward the vertical position, wherein the upward biasing force is defined by the one spring being in compression and the opposing negative biasing force is defined by the one spring being in tension.

US Pat. No. 10,597,241

CARGO TRANSFER SYSTEM USING A PALLETIZED RACK

American Refrigerated Exp...

1. A method for bulk loading a railcar comprising:bulk loading a multi-tiered rack with cargo, wherein said multi-tiered rack comprises at least a first base tier and a second adjustably positioned tier above said first tier, said first and second tiers configured to be air permeable by having a wire mesh positioned thereon to support the cargo while allowing air to pass therethrough;
transporting said loaded multi-tiered rack through an opening of the railcar;
positioning said loaded multi-tiered rack onto a plurality of tracks positioned on a floor of the railcar;
moving said loaded multi-tiered rack from a position proximate said opening to a position within the railcar, said moving being conducted on a plurality of pneumatically extendable rollers extending from said plurality of tracks; and
securing said loaded multi-tiered rack in the railcar by retracting said extendable rollers to lower said loaded rack onto a loading surface.

US Pat. No. 10,597,240

CONVEYANCE FACILITY

DAIFUKU CO., LTD., Osaka...

1. A conveyance facility for conveying an article along a conveyance path, comprising:a conveyance unit comprising a traveling body traveling on the conveyance path, and a support traveling with the traveling body and supporting the article being suspended, the conveyance unit conveying the article along the conveyance path; and
a traveling rail provided along the conveyance path and supporting the traveling body so as to be travelable, wherein the traveling rail comprises:
a friction transmission belt in frictional contact with the support; and
a meshing transmission belt being meshed with the support, wherein both the friction transmission belt and the meshing transmission belt are arranged on the same traveling rail and each is operative to cause the traveling body to travel along at least a portion of the same traveling rail;
a sending device provided on the conveyance path, and sending out a plurality of the conveyance units traveling on the conveyance path, at predetermined intervals,
wherein the friction transmission belt is arranged on an upstream side from a position where the sending device is arranged, and
wherein the meshing transmission belt is arranged on the downstream side from the position where the sending device is arranged.

US Pat. No. 10,597,239

TRANSFER SYSTEM FOR CONTAINERS

1. A transfer system or transferring thermoplastic material containers from a linear operating machine to a rotary operating machine, comprisinga first linear transfer device apt to pick the thermoplastic material containers from the linear operating machine in a picking zone and to translate along a first axis from said picking zone to an exchange zone, and vice versa,
a wheel apt to cooperate with the rotary operating machine peripherally provided with seats for the thermoplastic material containers, and apt to rotate about a second axis perpendicular to the first axis,
at least one second linear transfer device apt to pick the thermoplastic material containers from the first linear transfer device in said exchange zone, and to transfer them to said seats, said at least one second linear transfer device being apt to translate parallel to said first axis from the exchange zone to an unloading zone proximal to the wheel, and vice versa,wherein the first linear transfer device is provided with retaining means for retaining the thermoplastic material containers and the at least one second linear transfer device is provided with gripping means for picking the thermoplastic material containers from corresponding retaining means in the exchange zone, said retaining means being equally spaced apart by a first pitch equal to the pitch of said gripping means,wherein the seats are equally spaced apart by a second pitch which is different from said first pitch,and wherein the seats are shaped so that a periphery of the wheel has a sawtooth-shaped profiler wherein a profile of the periphery of the wheel at each seat comprises a first curved stretch and a second curved stretch adjacent to the first curved stretch, and wherein there is an inflection point between the first curved stretch and the second curved stretch.

US Pat. No. 10,597,234

CARTON UNLOADER TOOL FOR JAM RECOVERY

Intelligrated Headquarter...

1. A method of conveying articles on a robotic material handling system, the method comprising:positioning a nose conveyor surface of the robotic material handling system proximate to an article pile, the nose conveyor surface being vertically-movable and having two or more parallel conveyors that are distal to and feed a rearward conveyor, the rearward conveyor being laterally narrower than the nose conveyor surface;
robotically moving one or more articles onto the nose conveyor surface from the article pile;
activating at least one of the two or more parallel conveyors of the nose conveyor surface to convey at least one article from the nose conveyor surface toward the rearward conveyor;
detecting a jammed article that is at least partially supported by the nose conveyor surface and that has failed to be fully conveyed onto the rearward conveyor by the at least one of the two or more parallel conveyors;
dislodging the jammed article by causing at least one of: (i) vertically repositioning the nose conveyor surface; and (ii) activating the at least one of the two or more parallel conveyors of the nose conveyor surface to run in a forward direction;
activating at least one parallel conveyor that is in contact with the jammed article in a rearward direction to convey a portion of the jammed article in the rearward direction; and
activating the two or more parallel conveyors in the rearward direction to convey remaining portions of the jammed article in the rearward direction.

US Pat. No. 10,597,233

RAIL MODULE HAVING RAIL PORTIONS AND HAVING A LINEAR DRIVE, CARRIAGE FOR A RAIL MODULE AND RAIL TRANSPORT SYSTEM

1. A rail-bound carriage (6) for a rail module (1), the rail module comprisingrail portions (2) and
a linear drive for moving the rail-bound carriage (6),
wherein the linear drive has at least one drive module (3), which can be brought into operative connection with at least one reaction element (7),
wherein, when the reaction element (7) and the carriage (6) are used as intended, the at least one reaction element (7) is secured independently of the drive module (3) to the carriage in a drive region and the drive region faces the drive module (3) when the carriage is arranged as intended on the rail portions (2),
wherein the drive module (3) is arranged fixedly in relation to the rail module (1),
wherein the drive module (3) has at least one first and at least one second drive apparatus (4) for driving the carriage (6) along at least one first and along at least one second movement axis,
wherein at least one work machine (8) is assigned to each drive apparatus (4) and each movement axis and wherein each drive apparatus (4) has a pinion (5) driven by the work machine (8),
wherein the pinion (5) and the at least one reaction element (7) are adapted to each other and arranged in relation to each other such that, when the rail module (1) is used as intended, by means of the reaction element (7) a drive action of the pinion (5) of a drive apparatus (4) is converted to a translational movement of the carriage (6) along a movement axis assigned to the drive apparatus (4), so that the rail-bound carriage (6) can be moved along one of the movement axes,
wherein the pinion (5) has a disc-shaped or cylindrical basic body,
wherein the pinion (5) can be brought into rotation by the work machine (8),
wherein the reaction element (7) has at least one rack (13), which can engage with the pinion,
wherein, beside the rack (13), at least one meshing engagement aid (9) is arranged in the drive region of the carriage (6),
wherein the meshing engagement aid (9) is an elongated bar having teeth (10) which are arranged in alignment with teeth of the rack (13),
wherein the meshing engagement aid (9) has an insertion side (11) and a feed side (12), the feed side (12) facing a rack portion of the rack (13),
wherein a feed tooth pitch and/or depth in feed tooth portions of meshing engagement aid teeth (10) are adapted on the feed side (12) to a tooth pitch and/or depth of teeth of the rack (13) in the rack portion,
wherein an insertion tooth pitch in insertion tooth portions of the meshing engagement aid teeth (10) is greater on the insertion side (11) than the feed tooth pitch and/or an insertion tooth depth in insertion tooth portions of the meshing engagement aid teeth (10) is smaller on the insertion side (11) than the feed tooth depth, and
wherein the meshing engagement aid teeth (10) each run continuously from the insertion side (11) to the feed side (12), so that when the carriage (6) is moved transversely to the movement axis of a pinion (5) the rack (13) arranged on the carriage (6) can, in a trouble-free manner, be meshed with a pinion of the drive apparatus (4) of the rail module (1) or guided thereover.

US Pat. No. 10,597,232

SHEET BUNDLE CONVEYING APPARATUS

Duplo Seiko Corporation, ...

1. A sheet bundle conveying apparatus that conveys a sheet bundle formed of a predetermined number of sheets, the apparatus comprising:a plurality of conveying belts juxtaposed so that the sheet bundle is conveyed while being placed thereon;
a regulating guide that is movable so as to sandwich the sheet bundle placed on the conveying belts from both sides in a direction orthogonal to a conveyance direction;
a belt driving part that drives the conveying belts;
a guide driving part that drives the regulating guide; and
a driving control part that controls the belt driving part and the guide driving part,
wherein the conveying belts have stopping members having a form abuttable on a first end surface on an upstream side and/or a second end surface on a downstream side in the conveyance direction of the sheet bundle being placed, and have a placement area for the sheet bundle on the upstream side and/or the downstream side of the stopping members, and
(I) when the sheet bundle is placed on the placement area, the driving control part controls the belt driving part so that the conveying belts move so as to bring the stopping members to predetermined positions, respectively,
(II) after the sheet bundle is placed on the placement area, the driving control part (a) controls the guide driving part so that the regulating guide sandwiches the sheet bundle from both sides in the orthogonal direction and (b) controls the belt driving part so that at least one of the conveying belts is moved to make the stopping members of the conveying belt abut on the first end surface or the second end surface of the sheet bundle and at the same time or thereafter, make the second end surface or the first end surface of the sheet bundle abut on the stopping member of the other of the conveying belts, and
(III) the driving control part controls the belt driving part and the guide driving part so that the sheet bundle is conveyed along the regulating guide with the stopping members abutting on the first end surface and the second end surface as in the above (II),
wherein the stopping members have elasticity on abutting surfaces abutting on the first end surface and/or the second end surface of the sheet bundle.

US Pat. No. 10,597,231

SYSTEM AND METHOD FOR STORING WATER IN AN UNDERGROUND RESERVOIR AND MANAGING THE SAME

NEXT TIER AGRIBUSINESS, L...

1. A method for storing groundwater comprising the following steps:identifying a subsurface aquifer located beneath a developed parcel of land, the developed parcel of land having a ground surface at a base elevation, wherein the developed parcel of land has a surface use selected from the group consisting of agricultural, commercial, residential, and recreational, wherein the subsurface aquifer comprises a porous and permeable layer located at a first elevation;
storing water in a surface water storage facility located at a first location remote from the developed parcel of land;
conveying water through a piping system into the subsurface aquifer, wherein the piping system connects the surface water storage facility and the subsurface aquifer, the piping system comprising an array of conduit members, each conduit member having an outlet into the subsurface aquifer;
conveying water through the piping system into the subsurface aquifer; and
measuring the volume of water conveyed through the piping system to calculate a groundwater recharge credit from a total volume of water banked in the aquifer.

US Pat. No. 10,597,230

ARTICLE TRANSPORT FACILITY

Daifuku Co., Ltd., Osaka...

1. An article transport facility comprising:a storage rack in which a plurality of storage sections for storing articles are arranged in a first direction along a horizontal direction;
a rail installed on a floor along the first direction;
a first transport apparatus and a second transport apparatus that are guided by the rail to move in the first direction in front of the storage rack and transport the articles to the storage sections or from the storage sections;
a first cable body for power supply or communication that is connected to the first transport apparatus and extends in the first direction; and
a second cable body for power supply or communication that is connected to the second transport apparatus and extends in the first direction,
wherein:
both a first end, which is an end of the first cable body on a side opposite to a connecting portion thereof connected to the first transport apparatus, and a second end, which is an end of the second cable body on a side opposite to a connecting portion thereof connected to the second transport apparatus, are fixed to the floor,
the first cable body allows the first transport apparatus to move in a first movement area, which is an area extending along the first direction, by deforming as the first transport apparatus moves along the first direction,
the second cable body allows the second transport apparatus to move in a second movement area, which is an area extending along the first direction and at least partially overlapping the first movement area, by deforming as the second transport apparatus moves along the first direction, and
the first cable body and the second cable body are arranged on the same side in a second direction, which is perpendicular to both the first direction and an up-down direction, relative to the rail so that an area in which the first cable body is arranged and an area in which the second cable body is arranged in the second direction at least partially overlap each other.

US Pat. No. 10,597,229

STACKER CRANE WITH AN IMPROVED SLIDING MECHANISM

INPECO HOLDING LTD., Qor...

1. A stacker crane for transporting, inserting and picking containers of biological material test tubes in/from locations of a plurality of shelves of a storage for storing said containers of biological material test tubes, said stacker crane is able to move said containers of biological material test tubes in the three Cartesian directions x, y and z, so as to reach said locations, and comprises:first guide means along said direction x, comprising a first pair of guides;
second guide means along said direction y, orthogonal to said direction x, comprising at least a second pair of guides;
a movable structure comprising a first carriage and a second carriage, said first carriage is able to slide integrally with said second carriage in said direction x along said first pair of guides;
wherein said second pair of guides is separate and independent from said first carriage and from said second carriage,
said first carriage is integrally provided with a third pair of guides for said second carriage, which contribute to form said second guide means when said first carriage is arranged at said second pair of guides, thus aligning said third pair of guides to said second pair of guides,
to each of said first carriage and second carriage is integrally connected at least one pair of sliding mechanisms located along the respective ends, and
said second carriage is able to slide independently of, and to be released from, said first carriage along said second guide means in said direction y, by the translational movement of said sliding mechanisms of said second carriage from said third pair of guides to said second pair of guides and vice versa;
wherein said sliding mechanisms comprise one or more sliders able to slide inside said first, second and third pairs of guides; and
wherein said sliding mechanisms comprise a coupling plate, to be attached to said first carriage and second carriage respectively, which supports rolling means able to slide inside said first, second and third pairs of guides and to transform the sliding friction of said sliding movement into rolling friction;
wherein said sliders comprise end members coupled to the edges of said coupling plate which, along with said first, second and third pairs of guides, close a containment space of said rolling means so as to prevent impurities from entering.

US Pat. No. 10,597,228

MAGNETIC DRIVE INTELLIGENT TRASH BIN LID ASSEMBLY

1. A magnetic drive intelligent trash bin lid assembly, the assembly comprising:a lid portion having:
a shell having a lid shaft, a bottom, and a top;
a shell cover joined to the shell; and
whereby the shell selectively pivots about the lid shaft in an arcuate path between an open position and a closed position;
a variable linkage connected to the shell, the variable linkage having:
a shaft;
a crankshaft; and
a cover seat receiving the lid shaft;
a drive motor comprising a rotatable output shaft, the drive motor being operable to rotate the rotatable output shaft;
a sensor being operatively connected to the drive motor, the sensor detecting a sensory motion near the lid portion, whereby the sensor activates the drive motor when a sensory motion is detected;
whereby, the output shaft rotates when the sensor detects motion;
a magnetic clutch receiving the output shaft, the magnetic clutch selectively engaging and disengaging the drive motor and the variable linkage, the magnetic clutch having:
a first magnet positioned in a magnet front seat;
a second magnet positioned in a magnet rear seat;
an elastic seat; and
a rotatable shaft extending from the elastic seat, the magnets and the elastic seat being coaxially arranged in a coaxial configuration, whereby the magnets are releasable from the seats to magnetically attract;
a spring defined by two ends, the ends of the spring being inserted into the magnet rear seat and the elastic seat, respectively, whereby the spring helps absorb axial and rotational forces applied to the magnetic clutch;
whereby, rotation of the output shaft releases the first magnet from the magnet front seat, and releases the second magnet from the magnet rear seat, thereby causing the first and second magnets to draw together, thereby causing the elastic seat to be axially displaced towards the output shaft, thereby causing the rotatable shaft extending from the elastic seat to engage the crankshaft, thereby causing the crankshaft to convert the axial displacement along the magnetic clutch to a rotational motion against the lid shaft, thereby causing the lid shaft to pivot the shell to the open position;
whereby the spring helps reduce an axial force from the displacement of the elastic seat towards the output shaft; and
whereby, cessation of rotation by the output shaft engages the first magnet to rest in the magnet front seat, and engages the second magnet to rest in the magnet rear seat, thereby causing the first and second magnets to withdraw, thereby causing the elastic seat to be axially displaced away from the output shaft, thereby causing the rotatable shaft extending from the elastic seat to disengage the crankshaft, thereby causing the lid shaft to release the shell to the closed position.

US Pat. No. 10,597,225

TRUCK BODY

GECKO TANKS PTY LTD, Wel...

1. A tank for mounting on a load carrying platform of a service truck to transport a first fluid in a main chamber and at least one second fluid in at least one sub-chamber permitting storing the second fluid separate from the first fluid, the main chamber and the at least one sub-chamber being fluidly connected to piping of the service truck for either filling the main chamber with the first fluid and the at least one sub-chamber with the second fluid or delivering the first fluid and the second fluid to delivery means for delivering the first fluid and the second fluid outside the main chamber and the at least one sub-chamber to locations distal to the service truck, the tank comprising:the main chamber having an exterior surface defining an inner volume adapted to receive the first fluid, and
the at least one sub-chamber having first and second ends and a side wall having an exterior surface located within the inner volume of the main chamber, and an inner surface defining an inner volume within the at least one sub-chamber to store the second fluid, the side wall of the at least one sub-chamber having at least one first location comprising a first gate, the first gate being adapted to be selectively displaced between a closed condition to keep the second fluid separate from the first fluid and an open condition to allow flow of the first fluid into the inner volume of the at least one sub-chamber;
each end comprising a second location comprising a second gate adapted to be selectively displaced between an open condition and a closed condition to allow flow of the second fluid into the inner volume of the at least one sub-chamber, and
wherein the at least one sub-chamber is arranged with respect to the main chamber such that the first location comprising the first gate is located within the main chamber and the second location comprising the second gate is located exterior to the main chamber and the side wall of the at least one sub-chamber is located within the inner volume of the main chamber in order for the exterior surface of the side wall of the at least one sub-chamber to be surrounded by the first fluid.

US Pat. No. 10,597,224

CAPSULE, SYSTEM AND METHOD FOR PREPARING A PREDETERMINED QUANTITY OF BEVERAGE SUITABLE FOR CONSUMPTION

Koninklijke Douwe Egberts...

1. A capsule for preparing a predetermined quantity of beverage suitable for consumption using an extractable product, by means of a beverage brewing device comprising a receptacle for receiving the capsule, comprisinga cup comprising a circumferential wall, a bottom closing the circumferential wall at a first end, and
a lid in use connected to the cup at a second end of the circumferential wall opposite the bottom,
wherein the wall, bottom and lid, in use, enclose an inner space comprising the extractable product,
wherein at least a portion of a surface of the capsule conceived to, in use, interact with the receptacle is provided with at least one projection for forming a sealing engagement with the receptacle; and
wherein the at least one projection comprises a sponge capable of retaining fluid.

US Pat. No. 10,597,223

BOX-IN-BOX CONTAINER

Altria Client Services LL...

1. A container for consumer goods comprising: a rigid outer box having a hinged lid configured to provide access to an inner volume of the outer box; a rigid inner box comprising panels separated by fold lines and assembled from an inner box blank including a top front panel separated from a top panel by a first transverse fold line, a back panel separated from the top panel by a second transverse fold line, a bottom panel separated from the back panel by a third transverse fold line, and a bottom front panel separated from the bottom panel by a fourth transverse fold line, wherein the top panel and top front panel include a pre-cut opening therein configured to provide access to an inner volume of the inner box, and the inner box blank comprises a plurality of layers including paperboard and bundle wrap, the bundle wrap including a layer of foil and a layer of paper forming an inner liner of the inner box wherein the layer of foil is between the paperboard and the paper layer.

US Pat. No. 10,597,220

DEVICE FOR PRODUCING SCLEROSING MICROFOAM

PROVENSIS LIMITED, Londo...

1. An adaptor for connecting a filling or dispensing means to a valve of a pressurisable container, said adaptor comprising:a cylindrical element with open ends and an inner wall and an outer wall therebetween, said open ends comprising a lower open end configured to enable attachment to the pressurisable container and an upper open end configured to enable attachment of a filling means or a dispensing means;
an inner bore to accommodate the valve of the pressurisable container and enable engagement of the valve with the filling means or dispensing means when attached through the upper open end of the device;
wherein the outer wall of the adaptor comprises three or more evenly spaced cam tracks which circumferentially and downwardly extend from a top initial portion to a bottom terminal end wall at a terminal end of each cam track, which cooperate with corresponding cams on the filling means or dispensing means, and which connect the valve of the pressurisable container to a fluid path of the filling or dispensing means when the pressurisable container and filling or dispensing means are rotated relative to each other.

US Pat. No. 10,597,218

GLOVE PACKAGING HAVING ANTIMICROBIAL BARRIER

Medline Industries, Inc.,...

1. A glove container comprising:a plurality of disposable polymeric gloves;
a container body enclosing therein the disposable polymeric gloves, the container body having an opening through which the disposable polymeric gloves are removable by a user;
a film attached to an underside surface of the container body via an adhesive, the film covering the opening and including a slit through which one or more of the disposable polymeric gloves is removable by the user, each glove of the disposable polymeric gloves being completely within the container body prior to the user inserting a hand through the slit to obtain each glove; and
an antimicrobial material incorporated within the film to create a contaminant free zone, the antimicrobial material having a predetermined antimicrobial activity value.

US Pat. No. 10,597,217

VACUUM-DRAWING LID

LIFETIME BRANDS, INC., G...

1. A lid for sealing a container, comprising:a base frame including a first valve and a plurality of vertically extending ridges;
a piston including a second valve and a plurality of vertically extending grooves configured to engage with the ridges; and
a chamber bounded at least in part by the base frame and the piston,
the piston movable in a first direction with respect to the base frame to change a volume of the chamber to actuate the first valve, the piston movable in a second direction opposite to the first direction to change the volume of the chamber to actuate the second valve.

US Pat. No. 10,597,213

PRESSURE REDUCTION-ABSORBING BOTTLE

YOSHINO KOGYOSHO CO., LTD...

1. A pressure reduction-absorbing bottle having a cylindrical shape with a bottom and formed of a synthetic resin material, the bottle comprising:a bottom wall portion in a bottom portion of the bottle including:
a grounding portion positioned at an outer circumferential edge of the bottom wall portion;
a rising circumferential wall portion connected to the grounding portion from an inner side of the bottle in a bottle radial direction and extending upward;
an annular movable wall portion extending from an upper end portion of the rising circumferential wall portion toward the inner side of the bottle in the bottle radial direction; and
a central wall portion connected to an inner end portion of the movable wall portion in the bottle radial direction, wherein
the movable wall portion is arranged to be configured to be freely rotationally moved about a connection portion between the movable wall portion and the rising circumferential wall portion in a vertical direction together with the central wall portion and the movable wall portion includes a curved portion having a curved surface shape protruding downward,
the curved portion is connected to an outer end portion of the central wall portion in the bottle radial direction, and
a lowest portion of the curved portion positioned at a lowest position thereof is disposed at a portion of the curved portion positioned further outward in the bottle radial direction than a central position of the curved portion positioned at a center between outer and inner ends of the curved portion in the bottle radial direction.

US Pat. No. 10,597,211

FLUID HANDLING CONTAINERS, SYSTEMS, AND RELATED METHODS

PALL LIFE SCIENCES BELGIU...

1. An apparatus for receiving an at least partially flexible vessel adapted for receiving a fluid, comprising:an overpack including a base having a floor and an upstanding sidewall forming an interior for receiving the vessel; and
a partition removably positioned in the interior of the overpack, the partition extending generally transverse to the sidewall and generally aligned with the floor to form a compartment in the interior of the overpack for receiving the vessel;
wherein the base of the overpack includes a door for providing access to an exterior compartment of the base.

US Pat. No. 10,597,210

FLEXIBLE POUCH WITH MICROCAPILLARY DISPENSING SYSTEM

Dow Global Technologies L...

1. A flexible pouch comprising:opposing flexible films, the flexible films defining a common peripheral edge;
a microcapillary strip sealed between the opposing flexible films, the microcapillary strip composed of a matrix of a polymeric material, and a plurality of channels wholly disposed in the matrix polymeric material;
a first side of the microcapillary strip located at a first side of the common peripheral edge and a second side of the microcapillary strip located at a second side of the common peripheral edge;
a peripheral seal along at least a portion of the common peripheral edge, the peripheral seal comprising a sealed microcapillary segment.

US Pat. No. 10,597,208

BIODEGRADABLE PERSONAL CARE SYSTEMS

On The Go Products Co., ...

1. A biodegradable personal care system, comprising:a biodegradable housing;
a biodegradable dry wipe container positioned in the biodegradable housing;
a biodegradable dry wipe positioned inside the biodegradable dry wipe container;
a biodegradable airtight container positioned in the biodegradable dry wipe container; and
a biodegradable moist wipe positioned inside the biodegradable airtight container.

US Pat. No. 10,597,207

FILLABLE CAP CLOSURE WITH A FILM SEAL THAT IS OPENED PURELY BY MEANS OF ROTATION OR AXIAL PRESSING

BEVASWISS AG, Neuhausen ...

1. A fillable cap closure for receiving and film-sealing a liquid or pourable filling in an interior cavity of a container and for emptying by purely rotating a twist cap (1), the fillable cap closure comprising:a receiving part (3) is screwed onto a threaded connection piece of the container, the receiving part having a cylinder (7) which is open at a bottom of the cylinder, wherein the cylinder (7) is sealed by a film at the bottom; and
a cup (2) which is inserted into the cylinder (7), the cup comprising at an edge of the cup at least one piercing and cutting tooth (5) which extends over the edge in an axial direction, and a plurality of guide means in the form of two depressions (9) which are opposite one another on an outer wall of the cup (2) and initially opposite a base of the cup, the two depressions each forming an oblique surface (27) on an end facing away from the base of the cup, wherein the twist cap (1) is provided with drivers (8) which engage in the depressions (9) on the cup (2) to open and pivot down the film by rotating the twist cap, wherein a first rotation the drivers (8) can drive onto each oblique surface (27) and an axial displacement of the cup (2) downwards is brought about to pierce through the film (33), then by further horizontally rotating the twist cap (1), in that the drivers (8) rotate the cup by abutting lateral surfaces of the depressions (9), the film (33) is cut open along a circumference thereof by less than 360°, and by subsequently further rotating the twist cap, another axial displacement of the cup (2) downwards to fold down the film (33) is brought about by ribs (10) that extend axially on the outer wall of the cup (2) moving down a guide rib (24) that extends at an oblique angle on an inner wall of the cylinder (7).

US Pat. No. 10,597,206

MEDICINE CONTAINER COVER

9. A medicine container assembly comprising:a medicine container defining a cavity; and
a cover attached to the medicine container, the cover comprising:
a top layer forming a top surface of the cover;
a wireless controller layer beneath the top layer, the wireless controller layer comprising a transceiver, micro controller, memory, and power source, wherein upon instruction to the micro controller, an opening mechanism within the cover is caused to be activated to release a deactivating material into the medicine container;
a motor mounted to a layer positioned beneath the wireless controller layer, the motor connected to the opening mechanism, the opening mechanism adapted to, upon actuation by the motor, release the deactivating material from a first deactivating material container layer; and
wherein the opening mechanism comprises a rotatable layer with at least one depending arm, the at least one depending arm engaged with a rotatable disc with an aperture alignable with an opening in the first deactivating material layer, such that upon rotation of the rotatable layer, the rotatable disc is moved to an open position allowing a release of the deactivating material.

US Pat. No. 10,597,205

CONTAINER FOR A GOVERNMENT REGULATED PRODUCT HAVING A CHILD RESISTANT LID

N2 PACKAGING SYSTEMS, LLC...

1. A container for storage, preservation, identification and tracking of a government regulated product comprising:(a) a one or more-piece container having an outer portion having an exterior surface and an inner portion having an interior surface, an upper portion and a lower portion, configured for containing a government regulated product;
(b) a two-piece re-sealable child resistant lid affixed to said upper portion of said container, wherein said child resistant lid includes a contoured upper surface, a locking inner ring having a plurality of restraining teeth which engage with an external locking trough located on the circumference of a locking member having a relief area to access a nib section and an indicator section for the purpose of locking and unlocking said child resistant lid; and
(c) identifying indicia including an electronically readable identification tag located on the outer portion exterior surface of said container, for identifying and tracking the contained government regulated product contents within said container;
wherein said container configured for containing a government regulated product is securely re-sealable using said two-piece re-sealable child resistant lid, after the sealed container is opened to access the government regulated product within said container.

US Pat. No. 10,597,204

TRAVEL BOTTLE WITH SLIDE LOCK

Navajo Manufacturing Comp...

1. A cap of a dispensing bottle, said cap comprisinga main body having a lid,
a top body secured to said main body, and
a switch plate secured between said main body and said top body, said switch plate including a handle for moving said switch plate between a locked position and an unlocked position, said lid being closeable when said switch plate is in said locked position and said lid being prevented from closing when said switch plate is in said unlocked position,
said lid including a projection, said projection engaging said handle to prevent closure of said lid when said switch plate is in said unlocked position,
said projection avoiding contact with an upper end of said handle to allow said lid to be closed when said switch plate is in said locked position.

US Pat. No. 10,597,203

CONTAINER

MERRY ELECTRONICS (SHENZH...

1. A container, comprising:a first cover;
a second cover;
a rotating shaft engaged between the first cover and the second cover, such that the first cover and the second cover are rotatable relative to each other;
an acting portion connected to the rotating shaft;
a multiple bending elastic piece comprising a fixing portion fixed to the first cover, an interfering portion located between the fixing portion and the rotating shaft, and an abutting portion connected to the interfering portion, wherein, while the rotating shaft is rotating relative to the first cover, the acting portion changes a bending degree of the multiple bending elastic piece with the rotation of the rotating shaft, thereby enabling the interfering portion to selectively contact opposite sides of the acting portion;
a limiting plate covering the acting portion and the interfering portion, wherein the abutting portion of the multiple bending elastic piece is located closer to the limiting plate than the interfering portion; and
a buffering layer disposed on the abutting portion of the multiple bending elastic piece and located between the abutting portion and the limiting plate.

US Pat. No. 10,597,202

RESEALABLE LIDDING WITH PATTERNED ADHESIVE

Sonoco Development, Inc.,...

1. A package comprising:a rigid base member defining a cavity configured to receive an item therein, the base member have a peripheral flange surface; and
a flexible lidding member configured to be engage on a perimeter portion the flange and to cover the cavity within the base member, the lidding member having
a first layer, the first layer having a first layer perimeter portion that is fixed to the flange of the base member, and a first layer central portion spaced inwardly of the first layer perimeter portion,
a second layer adhered to the first layer,
an adhesive layer, the adhesive layer having
a pattern applied permanent adhesive central portion, the central adhesive portion spaced inwardly from the first layer perimeter portion and permanently adhering the second layer to the first layer central portion, and
a pattern applied pressure sensitive perimeter adhesive portion surrounding the central adhesive portion and overlapping with the flange of the base member, the perimeter adhesive portion configured to permit a perimeter portion of the second layer to at least partially separate from the first layer perimeter portion during a peeled opening of the lidding member from the base member;
a central score line within the first layer, the central score line substantially surrounding the central adhesive portion, wherein the central score line permits the first layer perimeter portion to separate from the remainder of lidding member during the peeled opening of the lidding member, and
a tab portion formed as part of the perimeter portion of the lidding member, the tab portion having an edge score line formed in the first layer, the edge score line positioned directly adjacent the fixed perimeter portion of the first layer,
wherein the tab portion starts the peeling of the lidding member, with the second layer separating from the first layer between the edge score line and the central score line, exposing the perimeter adhesive portion, and
wherein the exposed perimeter adhesive portion permits the selective resealing of the second layer to the perimeter portion of the first layer and the closing of the cavity of the base member.

US Pat. No. 10,597,198

RECLOSABLE VACUUM-TIGHT POUCH AND RESEALABLE VACUUM-TIGHT CLOSURE MECHANISM THEREFOR

1. A reclosable vacuum-tight pouch comprising:(A) a first sidewall and a second sidewall joined together to define an interior and an opening of the pouch; and
(B) a closure mechanism attached to the first sidewall and the second sidewall along the opening of the pouch from a first end of the closure mechanism to a second end of the closure mechanism, the closure mechanism consisting of:
(i) a first base having an opening end and an interior end, the first base being attached to the first sidewall from the first end to the second end of the closure mechanism;
(ii) a first interlocking profile extending from the first base;
(iii) a first flange extending along a length of the first base from the first interlocking profile to the opening end of the first base, the first flange being attached to the first sidewall of the pouch at the opening end of the first base, from the first end to the second end of the closure mechanism;
(iv) a second interlocking profile extending from the first base;
(v) a second flange extending along a length of the first base from the second interlocking profile to the interior end of the first base, the second flange being unattached to the first sidewall of the pouch at the interior end of the first base, from the first end to the second end of the closure mechanism;
(vi) a first sealing member extending from the first base, the first sealing member being positioned between and spaced from the first and second interlocking profiles, such that the first sealing member is spaced from the first interlocking profile by a first separation distance to create a space between the first sealing member and the first interlocking profile, the first sealing member comprising an extended region that extends from the first base and a protruding end comprising a bulbous head with a protruding end sealing surface disposed along the majority thereof;
(vii) a second base having an opening end and an interior end, the second base being attached to the second sidewall from the first end to the second end of the closure mechanism;
(viii) a third interlocking profile extending from the second base, the third interlocking profile being configured to occlude and to deocclude with the first interlocking profile;
(ix) a third flange extending along a length of the second base from the third interlocking profile to the opening end of the second base, the third flange being attached to the second sidewall of the pouch at the opening end of the second base, from the first end to the second end of the closure mechanism;
(x) a fourth interlocking profile extending from the second base, the fourth interlocking profile being configured to occlude and to deocclude with the second interlocking profile;
(xi) a fourth flange extending along a length of the second base from the fourth interlocking profile to the interior end of the second base, the fourth flange being attached to the second sidewall of the pouch at the interior end of the second base, from the first end to the second end of the closure mechanism;
(xii) a second sealing member extending from the second base, the second sealing member being positioned between and spaced from the third and fourth interlocking profiles, such that the second sealing member is spaced from the fourth interlocking profile by a second separation distance to create a space between the second sealing member and the fourth interlocking profile, the second sealing member comprising a grooved member that has a grooved member sealing surface disposed thereon, such that the grooved member sealing surface is complementary to and sealingly engages the protruding end sealing surface, by surrounding at least a majority of the protruding end sealing surface and forming a gastight seal therebetween;
(xiii) a first sealing reservoir protrusion extending from the first base, the first sealing reservoir protrusion being positioned in the space between the first sealing member and the first interlocking profile, such that the first sealing reservoir protrusion is spaced from the first and second sealing members, the first interlocking profile, and the second base, and the first sealing reservoir protrusion being of a size and a shape to form a seal within the space between the first sealing member and the first interlocking profile, the size and shape of the first sealing reservoir protrusion relating to the first separation distance of the first sealing member from the first interlocking profile;
(xiv) a second sealing reservoir protrusion extending from the second base, the second sealing reservoir protrusion being positioned in the space between the second sealing member and the fourth interlocking profile, such that the second sealing reservoir protrusion is spaced from the first and second sealing members, the fourth interlocking profile, and the first base, and the second sealing reservoir protrusion being of a size and a shape to form a seal within the space between the second sealing member and the fourth interlocking profile, the size and shape of the second sealing reservoir protrusion relating to the second separation distance of the second sealing member from the fourth interlocking profile;
(xv) a first end-stomp positioned at the first end of the closure mechanism; and
(xvi) a second end-stomp positioned at the second end of the closure mechanism,
wherein the first and second sealing reservoir protrusions eliminate any leakage paths in the first end-stomp and the second end-stomp by forming the seals within the respective spaces between the respective sealing members and the respective interlocking members.

US Pat. No. 10,597,197

BISTABLE PULL-SNAP HOLD OPEN MECHANISM AND METHOD

1. A fitment bistable pull-snap hold open mechanism, comprising:a flexible first flat strip comprised of a polyolefin material having:
a first end;
a second end opposite the first end;
an inner mating surface;
an outer bonding surface opposite the inner mating surface;
a flexible second flat strip positioned relative to the first flat strip, the second flat stripe comprised of a polyolefin having:
a first end;
a second end opposite the first end;
an inner mating surface;
an outer bonding surface opposite the inner mating surface;
one or more pivot members integrated into the second flat strip separating the second flat strip into a side seal portion and an operable portion, the side seal portion coupled to the operable portion,
wherein the first flat strip is coupled to the second flat strip at both the first ends and the seconds ends with two or more bonding points at each of the first and second ends,
wherein the one or pivot members comprise a vertical living hinge and a flexure allowing the fitment bistable pull-snap hold open mechanism to be biased between an open configuration and a closed configuration,
wherein the vertical living hinge does not extend to the top edge or the bottom edge of the second flat strip, and
wherein the first flat strip and the second flat strip are applied proximate the opening of a flexible package on the inside walls of the package.

US Pat. No. 10,597,196

TAMPER-EVIDENT MESH MATERIAL AND METHODS OF MANUFACTURE THEREFOR

JX NIPPON ANCI, INC., Ke...

1. A tamper-evident mesh material comprising:a nonwoven mesh fabric, said mesh fabric comprising a plurality of strands, said plurality of strands comprising overlying strands and underlying strands, wherein said underlying strands comprise a visual property, and wherein said overlying strands are bonded to said underlying strands at a plurality of crossover points; and,
a contrast layer, wherein said contrast layer is visually distinct from said visual property of said underlying strands, and wherein said contrast layer is disposed over at least a portion of each said overlying strand and each said underlying strand, and over said plurality of crossover points,
wherein breakage of a bond between at least one of said overlying strands and at least one of said underlying strands at a crossover point of said plurality of crossover points exposes said visual property of said at least one underlying strand at said crossover point to indicate breakage of said bond.

US Pat. No. 10,597,194

SEED CONTAINER AND SHELL RECEPTACLE

1. A seed container and shell receptacle, comprising:an outer container comprising an outer sidewall, a base, and an open upper end, defining an interior outer volume, wherein the base is removably securable to the outer sidewall;
an inner container comprising an inner sidewall, an open bottom end, and an open top end, wherein the inner container is adapted to nest within the outer container such that the base of the outer container acts as an inner container base and defines an interior inner volume;
a lid having a first aperture disposed to give access to the interior outer volume and a second aperture disposed to give access to the interior inner volume, wherein the first aperture and the second aperture are adapted to be closed by a first door and a second door, respectively;
wherein the lid is removably securable to the open upper end of the outer container;
a lip extending perpendicularly inward from the outer sidewall at the base of the outer container; and
wherein the lip is configured to support the open bottom end of the inner container thereon when the base is removed from the outer container, such that the inner container is retained within the outer container thereby.

US Pat. No. 10,597,192

RESEALABLE BEVERAGE CAN LID

8. A resealable beverage can lid comprising:a lid having a top side having a first scored opening and a bottom side;
a first rivet formed in the lid and extending outwardly from the top side of the lid;
a tab portion connected to the first rivet;
a second rivet formed in the lid and extending outwardly from the top side of the lid, the second rivet having an indentation formed in the bottom side of the lid, the second rivet having a second scored opening; and
a closure element having a protrusion formed therein with the protrusion of the closure element fitting within the indentation of the second rivet formed in the bottom side of the lid.

US Pat. No. 10,597,191

PORTABLE CONTAINER AND CONTAINER ASSEMBLY

YETI Coolers, LLC, Austi...

1. An accessory for use with a portable container having a bottom and a sidewall extending upward from the bottom to define an internal cavity with a top opening, the accessory comprising:a jacket having a storage member and configured to extend around at least a portion of the sidewall of the container; and
a connection member comprising a connector configured to be connected to a port on the container such that a portion of the connector is received through the port, wherein the connection member is connected to the jacket and configured to support the jacket in connection with the container,
wherein the connector has an enlarged head and a stem depending from the enlarged head, wherein the connector is configured for connection to the port such that the enlarged head sits above the port and the stem depends downward through the port.

US Pat. No. 10,597,190

POURING ELEMENT FOR A COMPOSITE PACKAGING AND A COMPOSITE PACKAGING WITH A POURING ELEMENT

SIG Technology AG, Neuha...

1. A pouring element for a composite packaging, in particular for a beverage carton for liquid foods, with a basic body comprising a fastening flange and a pouring tube, a cutting element arranged and guided in the pouring tube, first guide means formed in the pouring tube and at least one pair of cams formed on the cutting element, wherein the first guide means and the at least one pair of cams cooperate correspondingly, wherein the first guide means is formed by a surrounding and self-contained rib.

US Pat. No. 10,597,189

JOINTED PACKAGE CORNER PROTECTOR

WUHAN CHINA STAR OPTOELEC...

1. A jointed package corner protector, comprising a plurality of corner plates and a connection assembly that connects two adjacent ones of the corner plates that are respectively set at upper and lower sides in a lengthwise direction of the corner plates;wherein each of the corner plates is formed, in each of two opposite, upper and lower, ends thereof, with first through holes that are substantially perpendicular to the lengthwise direction of the corner plates; the connection assembly comprises a joint sheath and a button fastener; and the joint sheath is formed with second through holes that correspond to the first through holes formed in an upper end portion of a lower one of the two adjacent corner plates that is located at the lower side and the first through holes formed in a lower end portion of an upper one of the two adjacent corner plates that is located at the upper side such that the button fastener is set to penetrate through corresponding ones of the first through holes and the second through holes to connect the two adjacent corner plates of the upper and lower sides to the joint sheath;
wherein the joint sheath has a cross-sectional shape that corresponds to and mates with a cross-sectional shape of the corner plates, and the cross-section of the corner plates is an L-shape;
wherein the corner plates each comprise a first vertical board extending in the lengthwise direction thereof and a second vertical board extending in the lengthwise direction of the corner plate and substantially perpendicular to the first vertical board, opposite upper and lower ends of the first vertical board and opposite upper and lower ends of the second vertical board being each formed with the first through holes;
wherein the upper and lower ends of the first vertical board and the upper and lower ends of the second vertical board are each formed with two first through holes;
wherein the joint sheath comprises a first connection board mateable with the first vertical board and a second connection board mateable with the second vertical board; and the first connection board is formed with four second through holes and the second connection board is formed with four second through holes;
wherein the joint sheath further comprises a third connection board corresponding to and opposite to the first connection board, a fourth connection board corresponding to and opposite to the second connection board, a first closure board connected between the first connection board and the third connection board, and a second closure board connected between the second connection board and the fourth connection board; the four second through holes formed in the first connection board are extended to penetrate through the third connection board, and the four second through holes formed in the second connection board are extended to penetrate through the fourth connection board; and the first connection board, the first closure board, the third connection board, the fourth connection board, the second closure board, and the second connection board collectively define an enclosure space, such that the two adjacent corner plates of the upper and lower sides have connectable portions that are respectively inserted into the enclosure space.

US Pat. No. 10,597,188

CONFIGURABLE CONTAINER ASSEMBLY

Tailgate N Go, Grand Jun...

1. A configurable container assembly comprising:a container defined by:
a bottom;
a left sidewall including a first set of slots located on top of and proximate an interior edge of the left sidewall and a second set of slots located on top of and proximate an exterior edge of the left sidewall;
a right sidewall including a third set of slots located on top of and proximate an interior edge of the right sidewall and a fourth set of slots located on top of and proximate an exterior edge of the right sidewall;
a front left wall including a fifth set of slots located on top of and proximate an interior edge of the front left wall and a sixth set of slots located on top of and proximate an exterior edge of the front left wall;
a front right wall including a seventh set of slots located on top of and proximate an interior edge of the front right wall and an eighth set of slots located on top of and proximate an exterior edge of the front right wall;
a back wall including a ninth set of slots located on top of and proximate an inside edge of the back wall;
a lid coupled to the back wall; and
a front middle wall located between the front left wall and the front right wall, the front middle wall adapted to rotate between being vertical and horizontal;
a first accessory including one or more protrusions, wherein the one or more protrusions are adapted to be inserted into one of the slots of the back wall, the left sidewall, the right sidewall, the front left wall, and the front right wall.

US Pat. No. 10,597,187

DOUBLED-WALLED CONTAINER

YOSHINO KOGYOSHO CO., LTD...

1. A double-walled container comprising: an outer layer body that is bottle-shaped and that includes a mouth, the mouth being cylindrical, a trunk that is connected to the mouth and has a diameter larger than a diameter of the mouth, and a bottom connected to the trunk; and an inner layer body that is accommodated inside the outer layer body, has a shape corresponding to a shape of the outer layer body and is configured to be deformed to undergo volume reduction, the mouth being provided with at least one air introduction hole that passes through the outer layer body and introduces air between the outer layer body and the inner layer body,the double-walled container further comprising: an engaging part for plug used for fitting a dispensing tool to the mouth by plugging; a neck ring provided around the mouth; and a plurality of ribs that are provided on at least an upper part of the trunk and extends in a direction from the mouth toward the bottom; wherein
the neck ring includes at least one ring diameter expansion part whose diameter is expanded by bending a peripheral wall forming the mouth so that it projects radially outward and at least one ring intermittent part that is circumferentially adjacent to the at least one ring diameter expansion part and whose diameter is less expanded than that of the at least one ring diameter expansion part, and
the plurality of ribs include at least one expanded diameter part rib whose upper end is disposed immediately below the at least one ring diameter expansion part and at least one intermittent part rib whose upper end is disposed immediately below the at least one ring intermittent part located immediately below the at least one air introduction hole, and the at least one intermittent part rib includes an extending portion extending beyond the upper end of the at least one expanded diameter part rib.

US Pat. No. 10,597,185

PACKAGING MATTRESSES AS A DOUBLE SPIRAL ROLL

Zinus Inc., Tracy, CA (U...

1. A method comprising:inserting a first mattress into a sheath;
compressing the first mattress such that air exits the sheath;
sealing the sheath such that air is prevented from re-entering the sheath;
placing a bottom surface of the first mattress on a rolling wrapper such that the rolling wrapper wraps around a first end of the first mattress and onto a top surface of the first mattress, wherein the bottom surface of the first mattress has a length;
inserting the first end of the first mattress into a mechanical roller;
rolling the first mattress by bending the first end of the first mattress over onto the top surface of the first mattress, wherein both the top surface and the bottom surface of the first mattress are covered by the rolling wrapper where the first end of the first mattress is rolled over onto the top surface of the first mattress;
continuing to roll the first mattress such that successive portions of the bottom surface of the first mattress become adjacent to successive portions of the top surface of the first mattress and such that the entire length of the bottom surface of the first mattress is covered by the rolling wrapper;
placing a bottom surface of a second mattress on the rolling wrapper such that a first end of the second mattress is adjacent to a second end of the first mattress, wherein the bottom surface of the second mattress has a length;
continuing to roll the first mattress such that successive portions of the bottom surface of the first mattress become adjacent to successive portions of a top surface of the second mattress;
continuing to roll the first mattress such that successive portions of the bottom surface of the second mattress become adjacent to successive portions of the top surface of the second mattress and such that the entire length of the bottom surface of the second mattress is covered by the rolling wrapper; and
taping a first location on the rolling wrapper to a second location on the rolling wrapper that has completed an additional wrap around the second mattress.

US Pat. No. 10,597,184

METHOD AND DEVICE FOR ASSEMBLING HEIGHT-ADJUSTABLE BOX

RENGO CO., LTD., Osaka (...

1. A height-adjustable box comprising:a base sheet and a cover sheet which are made of corrugated paperboard, wherein the base sheet comprises side sheet portions and folded sheet portions on both sides of a bottom sheet portion through first fold lines and second fold lines, and the cover sheet comprises side sheet portions and folded sheet portions on both sides of a top sheet portion through first fold lines and second fold lines,
wherein the side sheet portions and the folded sheet portions of the base sheet are bent upwardly along the first fold lines and the second lines, the cover sheet is positioned on the base sheet with the base sheet and the cover sheet arranged so that the base sheet crosses the cover sheet, the top sheet portion is bonded to the folded sheet portions of the base sheet, the side sheet portions and the folded sheet portions of the cover sheet are bent downwardly along the first fold lines and the second fold lines, and the folded sheet portions of the cover sheet are bonded to the bottom sheet portion,
wherein the cover sheet comprises protruding pieces which protrude from both sides of the cover sheet and are continuous from the first fold lines of the cover sheet to the folded sheet portions of the cover sheet; and
the base sheet comprises folded pieces, each of the folded pieces being separated into a first folded piece portion which protrudes from a corresponding one of the side sheet portions of the base sheet through a corresponding fold line of the base sheet and a second folded piece portion which protrudes from a corresponding one of the folded sheet portions of the base sheet through a respective fold line, by a cut disposed on an extension of a corresponding one of the second fold lines of the base sheet such that the first folded piece portion is bent outwardly so as to be disposed along an inner surface of a corresponding one of the protruding pieces of the cover sheet and the second folded piece portion is bent downwardly so as to be disposed along an inner surface of a corresponding one of the side sheet portions of the cover sheet so as to close a gap between the base sheet and the cover sheet at a corresponding corner of the height-adjustable box.

US Pat. No. 10,597,183

APPARATUS FOR HEAT SHRINKING A PACKAGE AND METHOD FOR HEAT SHRINKING A PACKAGE

Cryovac, LLC, Charlotte,...

1. An apparatus for heat shrinking a package, comprising:a chamber configured such that a package on a surface of the apparatus may be heat shrunk via a heating fluid in the chamber; and
a preheat container configured to supply a preheated liquid to a heat tank from which the heating fluid is supplied to the chamber;
wherein the preheat container is above said surface such that liquid in the preheat container can be preheated by heat from the chamber; and
wherein the preheat container is positioned on an upper surface of the chamber and directly above the chamber such that the preheated liquid is preheated above the chamber by heat rising upward in the chamber.

US Pat. No. 10,597,182

COMPOSITE REINFORCEMENT SYSTEMS AND METHODS OF MANUFACTURING THE SAME

NEPTUNE RESEARCH, LLC., ...

1. A repair kit for reinforcement of a physical structure, the repair kit comprising:a moisture-tight enclosure;
a carrier formed of a plurality of fibers within the moisture-tight enclosure; and
a moisture-curable prepolymer impregnating the carrier in a partially cured state, the moisture-curable prepolymer being formed of at least a polyfunctional aliphatic isocyanate and an aromatic-group-containing polyol as the only polyol;
wherein the polyfunctional aliphatic isocyanate is an isocyanurate-based polyfunctional isocyanate with an isocyanate functionality of greater than two,
the carrier is a fabric or includes unidirectional fiber layers therein,
the aromatic-group-containing polyol is based on a polymer selected from polyester, polyamide, polyurethane, polyurea, and a combination thereof and has aromatic groups in its backbone, and
the polyfunctional aliphatic isocyanate constitutes about 50 wt.% to 90 wt.% of the moisture-curable prepolymer, and the aromatic-group-containing polyol constitutes about 10 wt.% to 50 wt.% of the moisture-curable prepolymer.

US Pat. No. 10,597,179

AUTOMATIC RANDOM BOX SEALER AND METHOD OF SEALING BOXES OF DIFFERENT SIZES

Signode Industrial Group ...

1. A box sealer comprising:(a) a conveyor system including one or more conveyors;
(b) a first box measurer including a first sensor, a second sensor, and a top flap engager movable toward and away from the one or more conveyors;
(c) a second box measurer including a plurality of centering arms movable inwardly from disengaged positions to engaged positions;
(d) a flap closer;
(e) a tape applicator; and
(f) a control system configured to:
control the top flap engager to move from a disengaged position toward a box having multiple open upright flaps and positioned at a box measuring position;
receive, from the first sensor, a detection signal indicating that the first sensor has detected one of the upright open top flaps of the box and, responsive to receiving the detection signal, control the top flap engager to continue to move downward an additional distance to engage at least one of the upright open top flaps of the box and then stop;
receive, from the second sensor, a height signal associated with an amount of movement of the top flap engager;
control the centering arms to move from the disengaged positions to the engaged positions to engage opposing sides of the box;
receive, from the second box measurer, a width signal associated with an amount of movement of one of the centering arms; and
determine the height of the box based on the height and width signals.

US Pat. No. 10,597,178

METHOD AND APPARATUS FOR PROVIDING A CONTAINER TO A STERILE ENVIRONMENT

Medtronic Navigation, Inc...

1. A method of moving a member to a sterile field in an operating room, comprising:using a navigation system to track a tracking sensor;
covering a portion of a sterile user with a handle of a container extending from a container open end towards a container closed end while the sterile user is holding the container;
partially withdrawing a separate sleeve positioned completely within the container from the container at a first time;
positioning, by a non-sterile user, the member including a human input device in the container through a first open end of the sleeve positioned outside the container to contain the human input device within the container at a second time;
completely removing the separate sleeve from within the container at a third time after the second time;
maintaining the sterility of an exterior of the container while and after positioning the human input device within the container;
closing the container after positioning the human input device within the container in an operating room; and
using the human input device from within the closed container to provide input to the navigation system within the operating room.

US Pat. No. 10,597,177

APPARATUS AND METHOD FOR FILLING A PRODUCT INTO A CONTAINER

20. A computer storage system comprising a non-transitory storage device, said computer storage system having stored thereon executable program instructions that direct a computer system of an apparatus for filling a product into a container to at least:control a drive unit for moving the container in relation to a filling unit from a first position, in which a bottom end of the container is arranged at a maximum distance from a filling nozzle, to a second position, in which the bottom end of the container is arranged at a minimum distance from the filling nozzle;
open a first end of the filling unit and fill the product into the container;
move the container away from the first end of the filling unit by controlling the drive unit to step through a number of predefined positions while continuing to fill the product into the container;
close the first end of the filling unit when the container has been moved to a predefined end position; and
calculate an acceleration of the pump at predefined positions of the drive unit in order to obtain drive unit compensation distances as a function of the pump acceleration at each predefined position of the drive unit.

US Pat. No. 10,597,174

FILLING NOZZLE

SHIBUYA CORPORATION, Ish...

1. A filling nozzle comprising:a filling cylinder, in which an auger rotates about the axis of the filling cylinder to discharge powder through an opening provided at the lower end of the filling cylinder;
an air-injection cylinder fitted to the exterior of the filling cylinder to form an annular space between the filling cylinder and the air-injection cylinder; and
an air-supply unit supplying air in the annular space, the supplied air passing through the annular space;
the air-injection cylinder having a tip portion that extends downward below the opening and has an air-discharge mouth formed in a tapered shape such that the tip portion has a diameter smaller than that of the opening; and
the supplied air being injected from a space between the tip of the filling cylinder and the air-injection cylinder, and flows along the inner surface of the discharge mouth.

US Pat. No. 10,597,173

ROCKET LANDING SYSTEMS

1. A system for stabilizing a landing rocket, comprising:a first upright support structure;
a second upright support structure;
a third upright support structure;
a fourth upright support structure;
a first lateral support element extending from the first upright support structure to the second upright support structure;
a second lateral support element extending from the second upright support structure to the third upright support structure;
a third lateral support element extending from the third upright support structure to the fourth upright support structure;
a fourth lateral support element extending from the fourth upright support structure to the first upright support structure;
a first stabilizing element extending from the first lateral support element to the third lateral support element and movable along a length of the first lateral support element and along a length of the third lateral support element;
a second stabilizing element extending from the first lateral support element to the third lateral support element and movable independently of the first stabilizing element along the length of the first lateral support element and along the length of the third lateral support element;
a third stabilizing element extending from the second lateral support element to the fourth lateral support element and movable along a length of the second lateral support element and along a length of the fourth lateral support element; and
a fourth stabilizing element extending from the second lateral support element to the fourth lateral support element and movable independently of the third stabilizing element along the length of the second lateral support element and along the length of the fourth lateral support element.

US Pat. No. 10,597,171

METHOD FOR ESTIMATING THE PLAY IN AN ELECTROMECHANICAL ACTUATOR

1. A method for characterization of an amplitude (?S) of a play (S(t)) of an electromechanical actuator, the electromechanical actuator comprising an electric motor and a mobile element capable of being set in motion by the motor, said play (S(t)) being defined as a distance (m) or an angle (rad) which either of the motor or the mobile element has to travel through before the motor or the mobile element can cause a movement or a stress to the other of the motor or the mobile element,the actuator comprising an upstream sensor suitable for measuring a position of the motor (X1(t)) and a downstream sensor suitable for measuring a position of the mobile element (X2(t)), as well as a force sensor suitable for measuring a load applied to the mobile element (Fl(t)),
the method comprising the steps of:
measuring the position of the motor (X1(t)), the position of the mobile element (X2(t)) and the load applied (Fl(t)) to the mobile element using the three upstream sensor, the downstream sensor, and the force sensor, respectively,
from computer modelling of the actuator and the measured position of the motor (X1(t)), of the measured position of the mobile element (X2(t)) and of the measured load applied (Fl(t)) to the mobile element, estimating a value of play (S(t)) using a state observer by considering the play (S(t)) as a component of the state, a time derivative of the play S(t) being modelled in the form:
S(t)=0+b(t)
where S is the play, b is random white noise of known spectral density, and t is time,
one of the components of the state of the state observer being a deviation ?X(t) between the measured position of the mobile element X2(t) and the measured position of the motor X1(t), such that a state vector x is expressed in the following form:
x=[?X?X S]T
where ?X=X2?X1,
and a magnitude of measured output of the state observer is expressed in the following form:
y=[?X]T
and determining the amplitude of the play (?S) from a set of values of the play (S(t)) obtained at the estimating step for different instants in time (t).

US Pat. No. 10,597,170

ARRANGEMENT IN CATAPULT

ROBONIC LTD OY, Tampere ...

1. A launching cylinder of a catapult wherein the launching cylinder comprises:a frame comprising a cylindrical inner space;
a piston assembly arranged movably inside the inner space and being connected to a piston rod;
a first pressure space and a second pressure space inside the cylindrical inner space of the frame and being separated from each other by means of the piston assembly;
and wherein the first pressure space is connectable to a pneumatic circuit for generating launching movement towards a stroke direction of the launching cylinder, and the second pressure space on the side of the piston rod is connectable to a hydraulic circuit for generating return movement opposite to the stroke direction, whereby the launching cylinder is provided with combined pneumatic launching means and hydraulic returning means.

US Pat. No. 10,597,169

METHOD OF AERIAL VEHICLE-BASED IMAGE PROJECTION, DEVICE AND AERIAL VEHICLE

SZ DJI TECHNOLOGY CO., LT...

1. A method of image projection using an aerial vehicle, comprising:adjusting a position of the aerial vehicle to a projection-permitted position if an image projection event for the aerial vehicle is detected, comprising:
adjusting the position of the aerial vehicle if the image projection event for the aerial vehicle is detected;
obtaining, at the adjusted position, edges of a candidate obstacle, a distance from a point of the candidate obstacle to the aerial vehicle, and an obstacle image of the candidate obstacle captured in a projecting direction of a projector carried by the aerial vehicle;
determining whether the edges of the candidate obstacle, the distance from the point of the candidate obstacle, and a color and a texture of the candidate obstacle in the obstacle image satisfy a preset projection background condition; and
if the preset projection background condition is satisfied, determining that the candidate obstacle is a target obstacle satisfying the preset projection background condition and that the adjusted position is the projection-permitted position; and
triggering the projector carried by the aerial vehicle to project an image onto the target obstacle.

US Pat. No. 10,597,167

TIME TO ALTITUDE DISPLAY SYSTEM AND METHOD

Rockwell Collins, Inc., ...

1. A system for displaying range and time to altitude for an aircraft, comprising:a flight management system in communication with a plurality of sensors, the flight management system configured to receive flight data from the plurality of sensors including altitude and vertical speed measurements;
an aircraft display system; and
a controller in communication with the flight management system and the aircraft display system, the controller configured to:
receive a selected target altitude;
generate a range to altitude arc at a display of the aircraft display system based on the flight data and the selected target altitude;
determine a time to altitude based on the flight data and the selected target altitude by:
subtracting a current altitude from the selected target altitude to determine a difference between the current altitude and the selected target altitude; and
dividing the difference between the current altitude and the selected target altitude by a current vertical speed to determine the time to altitude; and
present the time to altitude in proximity to the range to altitude arc at the display of the aircraft display system.

US Pat. No. 10,597,166

IN-FLIGHT REFUELING PROBE FOR AN AIRCRAFT

NORTHROP GRUMMAN SYSTEMS ...

1. An in-flight refueling probe for an aircraft to be refueled by a fuel dispensing aircraft having a receptacle for connecting to the refueling probe, said refueling probe comprising:a first tubular member having first and second ends, said first end mounted to the aircraft and said second end extending from the aircraft, said first tubular member having an internal passage extending from said first end to said second end with said second end terminating in an external convex shape, said external convex shaped second end having a plurality of first holes equally spaced thereabout;
a second tubular member having first and second ends, said first end having an internal concave surface engaged with said external convex shaped end of said first tubular member, said first end of said second tubular member having a plurality of second holes there through in alignment with said plurality of first holes in said second end of said first tubular member;
a plurality of fasteners extending through said first and second holes joining said first end of said second tubular member to said second end of said first tubular member; the fasteners having a strength limited to a value that will break under a specific load on said nozzle;
a nozzle assembly mounted to said first end of said second tubular member for coupling to the receptacle on the fuel dispensing aircraft; and
at least one sealing member comprising an O-ring incorporated between said internal concave surface and said external convex shaped end and positioned upstream of the fasteners.

US Pat. No. 10,597,165

METHOD OF MANUFACTURING A STRAINER, A STRAINER, AND AN EJECTOR COMPRISING SUCH A STRAINER

Zodiac Aerotechnics, (FR...

1. A method for manufacturing a strainer used to transfer fuel between two tanks of an aircraft or to supply fuel to an engine, said strainer comprising:a housing having an open face for passage of the fuel, the open face being closed off by a grate acting as a filter; and
a conduit having a first open end and a second open end with a fuel passageway extending from the first open end to the second open end, wherein the first open end of the passageway is adapted to be connected to an inlet of an ejector, and wherein the second open end of the passageway terminates within the housing,
the method being characterized in that the method comprises the step of manufacturing the conduit, the housing and the grate of the strainer as a single monobloc part.

US Pat. No. 10,597,164

AIRCRAFT HAVING REDUNDANT DIRECTIONAL CONTROL

Textron Innovations Inc.,...

1. An aircraft having redundant directional control, the aircraft comprising:an airframe;
a two-dimensional distributed thrust array attached to the airframe, the thrust array including a plurality of propulsion assemblies; and
a flight control system operable to independently control each of the propulsion assemblies;
each propulsion assembly comprising:
a housing;
a gimbal coupled to the housing and operable to tilt about first and second axes;
first and second actuators operable to tilt the gimbal respectively about the first and second axes; and
a propulsion system coupled to and operable to tilt with the gimbal, the propulsion system including an electric motor having an output drive and a rotor assembly having a plurality of rotor blades, the rotor assembly rotatable with the output drive of the electric motor in a rotational plane to generate thrust having a thrust vector;
wherein, responsive to a thrust vector error of a first propulsion assembly, the flight control system commands at least a second propulsion assembly that is symmetrically disposed relative to the first propulsion assembly to counteract the thrust vector error, thereby providing redundant directional control for the aircraft.

US Pat. No. 10,597,162

MIXING BLEED AND RAM AIR AT A TURBINE INLET

HAMILTON SUNDSTRAND CORPO...

1. An airplane comprising:a first medium;
a second medium; and
an air conditioning system comprising:
a first turbine,
a compressor located upstream of the turbine in a flow path of the first medium,
a mixing point at which the first medium mixes with the second medium;
a heat exchanger configured to reject heat from the first medium to a third medium; and
a second heat exchanger configured to reject heat from the second medium to the third medium,
wherein the mixing point is downstream of the compressor and upstream of the turbine,
wherein the mixing point is located downstream of the heat exchanger and the second heat exchanger.

US Pat. No. 10,597,161

SPACE-OPTIMIZING SEATING ARRANGEMENTS FOR PASSENGER TRANSPORT AND METHODS THEREFOR

1. An aircraft cabin system, the system comprising:a lower deck defining a horizontal floor surface extending substantially in a horizontal plane that longitudinally divides an interior space of a fuselage section disposed at least partway between a nose and a tail of an airframe to form a cabin space above the lower deck;
an upper deck partition that longitudinally divides the cabin space to define a lower cabin space below the upper deck partition and above the lower deck, and further defining an upper cabin space above the upper deck partition and below a wall of the fuselage section, wherein a first portion of the upper deck partition has a first elevation above the lower deck along a longitudinal axis of the fuselage section;
an elevated walkway comprising an aisle in the upper cabin space, the aisle extending substantially parallel to the longitudinal axis of the aircraft and configured to permit a passenger to walk along the aisle in the upper cabin space;
a plurality of passenger cabins disposed in the upper cabin space arranged to form a single column of passenger cabins positioned along each lateral side of the elevated walkway, each one of the plurality of passenger cabins being at least partially disposed above a second portion of the upper deck partition at a second elevation above the lower deck, wherein the second elevation exceeds the first elevation, and each of the plurality of passenger cabins including a seat positioned therein adjacent the elevated walkway and a fixed bed positioned therein laterally adjacent the seat and apart from the elevated walkway, each of the seat and the fixed bed having a longitudinal axis extending substantially parallel to the longitudinal axis of the aircraft; and
a plurality of passenger seating spaces located in the lower cabin space between the second portion of the upper deck partition and the lower deck, wherein each of the plurality of passenger seating spaces located in the lower cabin space includes a seat positioned therein extending at an angle to the longitudinal axis of the aircraft;
wherein seat density in the lower cabin space is greater than seat density in the upper cabin space.

US Pat. No. 10,597,160

ARRANGEMENT WITH A PARTITIONING DEVICE IN A CABIN OF A VEHICLE AND AIRCRAFT WITH A CABIN AND SUCH AN ARRANGEMENT

AIRBUS OPERATIONS GMBH, ...

1. An arrangement for a cabin of a vehicle, comprising:a floor having a primary region and a secondary region separated by an aisle;
a first equipment component located in the primary region;
a second equipment component located in the primary region; and
a partitioning device located in the primary region and terminating at the aisle;
wherein the partitioning device is set up to provide a wall surface between the first equipment component and the second equipment component substantially perpendicular to the floor;
wherein the partitioning device is positionable in at least two positions along a length running between the first equipment component and the second equipment component;
wherein the partitioning device is lockable in its respective position on at least one of the floor, a cabin ceiling, and a cabin lining;
wherein the partitioning device comprises a guiding device and a dimensionally stable partition wall guided therein; and
wherein the guiding device is arranged on the cabin ceiling, and extends over the at least two positions.