US Pat. No. 10,136,986

DEVICES AND METHODS FOR ENDOTHELIALIZATION OF MAGNETIC VASCULAR GRAFTS

Mayo Foundation for Medic...

1. A method for making a porous, magnetic device consisting of a cured polymer and a magnetic substance and, optionally, a thread wound around the device, the method comprising:providing a solvent containing an uncured polymer, a porogen, and a magnetic substance;
providing an elongate mandrel having a length of at least about 3 cm and a diameter of about 100 ?m to about 6 mm;
dipping at least a portion of the mandrel into the solvent containing the polymer, porogen, and magnetic substance;
curing the polymer; and
removing the porogen.

US Pat. No. 10,136,985

METHOD OF RECONFIGURING A MITRAL VALVE ANNULUS

Millipede, Inc., Santa R...

1. A method of reconfiguring a mitral valve annulus, comprising:positioning an implant having a first diameter into a left atrium, the implant comprising a frame having a proximal end, a distal end, a pair of struts joined at an apex, a restraint positioned on the pair of struts, and a plurality of anchors near the distal end;
expanding the positioned implant to a second diameter that is larger than the first diameter;
connecting the expanded implant to tissue surrounding a mitral valve by embedding the plurality of anchors into the tissue;
moving the restraint axially relative to the apex along the pair of struts by rotating a shaft in threaded engagement with the restraint to cause the restraint to move axially along the pair of struts thereby adjusting an angle between the pair of struts to contract the implant.

US Pat. No. 10,136,984

SYSTEMS AND METHODS FOR MESH AUGMENTATION AND PREVENTION OF INCISIONAL HERNIA

THE TRUSTEES OF THE UNIVE...

1. A method for affixing mesh to a fascial incision to reinforce and augment hernia fascia closures, comprising:aligning a mesh strip over the fascial incision using an applicator, the mesh strip being integrated with one or more uni-directional fasteners, each fastener including at least one anchoring mechanism adapted for affixation to anterior abdominal wall fascia and a mating interface, the applicator comprising a first tension arm and a second tension arm adapted to interface with the mating interfaces of the fasteners to maintain a vertical tension of the mesh strip and a handle coupled with the first and second tension arms adapted to spread the first and second tension arms;
controlling a first horizontal tension of the mesh strip when the mesh strip is placed on the fascial incision by using the handle to spread the first tension arm a first distance from the second tension arm, the first distance corresponding to the first horizontal tension of the mesh strip, wherein the first horizontal tension corresponds to a predetermined amount of horizontal tension applied to the mesh strip by the applicator without application of external force;
affixing the mesh strip under the vertical tension and the first horizontal tension to the anterior abdominal wall fascia by applying a force to the fasteners to thereby achieve tissue penetration of the at least one anchoring mechanism of the one or more fasteners; and incrementally tensioning the mesh strip placed on the fascial incision to reinforce the fascial incision by using the handle to spread the first tension arm from the second tension arm by a second distance that is greater than the first distance, wherein an incremental horizontal tension corresponds to the second distance, the incremental horizontal tension being greater than the first horizontal tension.

US Pat. No. 10,136,983

MEDICAL DEVICE HAVING REMOVABLE DEPLOYMENT DEVICE AND AFFIXATION ELEMENT

ATRIUM MEDICAL CORPORATIO...

1. A medical device, comprising:a first layer having an opening formed therein;
a second layer positioned with respect to the first layer to form a pocket therebetween;
a support member at least partially located in the pocket and reconfigurable to enable removal of the support member from the pocket via the opening, wherein the support member includes a spiral separation line that enables the support member to unravel as material separates along the separation line when reconfiguring for removal via the opening; and
an affixation element located in the pocket between the support member and the second layer, and secured directly to a pocket-facing surface of the second layer by a component selected from the group consisting of stitching, a weld, an adhesive, and a fastener.

US Pat. No. 10,136,982

POLYHYDROXYALKANOATE MEDICAL TEXTILES AND FIBERS

Tepha, Inc., Lexington, ...

1. A knitted mesh, woven mesh, nonwoven mesh or braid comprising a poly-hydroxybutyrate homopolymer multifilament yarn, wherein the multifilament yarn has a tenacity of greater than 0.5 g/denier and is produced by a method comprising melt extrusion, allowing the extrudate dwell time to crystallize and drawing the resulting fiber.

US Pat. No. 10,136,981

TISSUE ANCHOR SYSTEM INCLUDING A SUTURE SECURING AN ANCHOR TO A SUPPORT

1. A tissue anchor system comprising:a support having a base and arms extending from the base, where the arms include a first arm separated from a second arm by a central portion of the support, where the support is a knitted mesh having open pores;
a suture inserted through the support, with a first trailing end portion and a second trailing end portion of the suture maintained inside of a conduit;
an anchor comprising a body, a fin extending from the body in a first direction with an eyelet formed in the fin, a pair of radial barrels extending from opposite sides of the body in a radial direction perpendicular to the first direction, with the suture engaged with the eyelet of the fin, and a gripping tab removably attached to the fin, where the gripping tab is adapted to be removed from the fin prior to insertion of the anchor into tissue; and
an introducer having a cannula defining a bore sized to receive the body of the anchor and a slot formed in a wall of the cannula, with the slot sized to receive the fin of the anchor.

US Pat. No. 10,136,980

IMPLANTS AND PROCEDURES FOR SUPPORTING ANATOMICAL STRUCTURES FOR TREATING CONDITIONS SUCH AS PELVIC ORGAN PROLAPSE

Caldera Medical, Inc., A...

1. A method for supporting an anatomical structure comprising:(a) making an entry point in a body of a patient;
(b) engaging a first anchor with a delivery system and inserting the first anchor through the entry point and into a target tissue of the body;
(c) retracting the delivery system from the first anchor and out from the entry point;
(d) reengaging the delivery system with the first anchor by passing a suture extending from the first anchor and out the entry point through a slot in the delivery system and advancing the delivery system towards the first anchor until the first anchor is received by the delivery system;
(e) adjusting a position of the first anchor in the target tissue with the delivery system and retracting the delivery system from the first anchor and out from the entry point after said adjusting;
(f) positioning a support member between the first anchor and a second anchor secured within said body;
(g) locking said support member in position relative to the first and second anchors by passing a mesh portion of the support member through an aperture of one of the first and second anchors and engaging said mesh portion of said support member with projections extending from an interior of the aperture by releasing a tension of a suture loop that passes through said aperture; and
(h) closing said entry point.

US Pat. No. 10,136,979

METHOD FOR CONTROLLING FLOW OF INTESTINAL CONTENTS IN A PATIENT'S INTESTINES

1. An intestinal dysfunction treatment apparatus comprising:an implantable constriction device configured to gently constrict at least one wall portion of a tissue wall of a patient's intestines to restrict a flow of intestinal contents in an intestinal passageway of the intestine's,
a stimulation device configured to stimulate the at least one wall portion of the tissue wall, and
a control device configured to be operable to control the stimulation device to stimulate the at least one wall portion, as the constriction device constricts the at least one wall portion, to cause contraction of the at least one wall portion to further restrict the flow of intestinal contents, wherein the control device is configured to control the constriction device to adjust the constriction of the at least one wall portion, and the control device is configured to control the constriction and stimulation devices independently of each other,
wherein the control device is configured to calibrate the constriction of the at least one wall portion by stimulating the at least one wall portion while adjusting, the constriction of the at least one wall portion until a desired restriction of the flow of intestinal contents in the intestinal passageway is obtained.

US Pat. No. 10,136,978

DOSING APPARATUS

Imaginus Limited, (NZ)

1. A dosing apparatus for dispensing therapeutic and/or preventative product into an orifice of an animal, comprising:a plurality of interlocking cartridges arranged in a stack, each cartridge containing at least one product, and each cartridge including:
a body with a cavity holding at least one product to be dosed,
a nozzle which is in communication with the cavity and which is configured for channelling the product to an orifice of an animal, the nozzle being disposed on the top of the body whereby product is dispensed upwardly from the dosing apparatus to the orifice of the animal,
at least one piston configured to push product from the cavity, and
a recess which is adapted to receive and provide a cover for the nozzle of an identical or similar cartridge; and
a dispenser for holding the cartridges and for dispensing product from each cartridge, one after the other, the dispenser including:
a magazine adapted to receive the stack of cartridges, and
a plunger arranged to drive the piston (s) of one of the cartridges;
wherein the nozzle comprises a cannula without a needle;
wherein the nozzle comprises a tubular section sized to fit within the teat orifice of a dairy cow for mastitis prevention and treatment; and
wherein the nozzle is disposed at an angle relative to the body of 70°-90°.

US Pat. No. 10,136,977

DENTAL TESTING DEVICE FOR HEAT SENSITIVITY

1. A device for testing a heat sensitivity in teeth comprising:a base; and
a testing tip having a cushion,
wherein the cushion comprises a heating element, wherein said heating element is embedded in said cushion; and
wherein the cushion is conformable to a contour of a tooth to be tested for a heat sensitivity and is conformable to contours of different types of teeth and wherein the cushion has a left side and a right side that are mirror images of each other that allows testing of all upper and lower teeth individually; and
being capable of transferring heat energy from the cushion to the top surface and at least one side surface of a tooth tested for heat sensitivity, wherein the surface of the cushion is adaptable to the surface of the tooth for greater surface area contact between the cushion and the tooth enamel allowing for heat energy transfer to the tooth over a larger area and at a level to prevent damage to the enamel layer, the dentine layer, or pulp tissue in the tooth being tested.

US Pat. No. 10,136,976

TOOTHBRUSH VIBRATOR

M-SYSTEM CO., LTD., Osak...

1. A toothbrush vibrator comprising:a vibration applicator having a case that allows a toothbrush to pass therethrough and holds the toothbrush and applying vibration to the toothbrush, the case being hollow pillar-shaped body; and
a grip detachably connected to the vibration applicator and gripped by a user,
wherein the grip has a case that is a hollow pillar-shaped body and is capable of housing a portion of a handle of the toothbrush that protrudes from the vibration applicator toward the grip,
the vibration applicator includes a first magnet provided at a grip-side end portion of the vibration applicator,
the grip includes a second magnet provided at a vibration applicator-side end portion of the grip, and
the vibration applicator and the grip are detachably connected by force of the first magnet and the second magnet attracting each other.

US Pat. No. 10,136,975

ORAL CAVITY SUCTION SYSTEM

1. A saliva ejection system comprising:a saliva ejector for placement within a patient's mouth;
a “U” configured hollow connector having an inner cheek nipple and an outer cheek nipple, said inner cheek nipple connected to said saliva ejector;
a sterile tube having a distal end and a proximal end, said distal end connected to said outer cheek nipple;
a quick connect fitting having an entrance nipple and an exit nipple; said proximal end of said sterile tube connected to said entrance nipple of said quick connect fitting;
a non-sterile tube having a first end and a second end, said first end connected to said exit nipple of said quick connect fitting; and
a vacuum fitting having a minor nipple and a major nipple, said second end of said non-sterile tube connected to said minor nipple wherein said saliva ejector comprises: a first and second generally planar plates having distal ends, proximal ends, an inner face, an outer face, and identically shaped perimeter edges; a suction connection tube disposed centrally between said plates and residing adjacent to said proximal ends, said connection tube having a vacuum connection end and a saliva inlet end; a series of embossings formed thereon said inner faces so as to form a series of saliva flow channels between said plates when said planar plates are conjoined and positioned in a spaced, parallel, mirror imaged configuration.

US Pat. No. 10,136,972

HISTORICAL SCAN REFERENCE FOR INTRAORAL SCANS

Align Technology, Inc., ...

1. A method comprising:receiving, by a processing device, a plurality of intraoral images of a dental site during an intraoral scan session;
determining, by the processing device, that a first intraoral image of the plurality of intraoral images does not satisfy a registration criterion with regards to any other intraoral oral image of the plurality of intraoral images;
determining, by the processing device, that a historical template of the dental site is existent, wherein the historical template is a virtual model of the dental site as generated from additional intraoral images taken during a previous intraoral scan session;
registering, by the processing device, the first intraoral image to one or more remaining intraoral images of the plurality of intraoral images in a three-dimensional space according to the historical template, wherein the first intraoral image is associated with a first region of the dental site that does not overlap with a second region of the dental site associated with the one or more remaining intraoral images;
generating a first surface of the first region based on the first intraoral image;
generating a second surface of the second region based on the one or more remaining intraoral images; and
displaying, by the processing device, relative positions and orientations of the first surface and the second surface, wherein the historical template is not displayed.

US Pat. No. 10,136,971

POSITIONING JIG AND IMPROVED METHODS TO DESIGN AND MANUFACTURE DENTAL IMPLANTS

1. A method of preparing an artificial prosthesis having two or more adjacent teeth which comprises:(a) preparing an artificial tooth arrangement (ATA) with two or more adjacent teeth in a mold on a positioning jig comprising a member with (i) three or more parallel bores in the member and (ii) one or more means for attaching the member to a dental articulator;
(b) placing at least three rigid struts in the parallel bores of the positioning jig;
(c) using at least one of the rigid struts to align a drill;
(d) drilling an aligned hole into each of the teeth in the mold;
(e) placing a rod in each of the aligned holes of the teeth to form a series of aligned rods;
(f) using the teeth and the aligned rods to prepare a dental mockup;
(g) copying the dental mockup to prepare a dental bridge; and
(h) affixing the teeth using the aligned holes to the dental bridge so as to prepare the artificial prosthesis.

US Pat. No. 10,136,970

SYSTEM, DEVICE, AND METHOD FOR DENTAL INTRAORAL SCANNING

DENTLYTEC G.P.L.LTD, Tel...

1. A method of imaging a tooth comprising:providing an intraoral scanner including a head portion having a shadow casting object, a light emitter, and an imager having known relative positions; wherein said head portion is sized and shaped to fit into a mouth of a subject;
moving said head portion around a perimeter of a tooth to scan a plurality of portions of an exterior surface of the tooth, wherein for each portion of said plurality of portions of said tooth, scanning comprises:
illuminating said portion of the tooth with said light emitter;
casting a shadow on said portion of the tooth by positioning said shadow casting object between said light emitter and said tooth;
imaging said portion of the tooth, including at least a part of said shadow, to produce one or more respective images of light collected from said portion of the tooth including at least two points on said portion of the tooth;
determining a pose of said imager from each of said one or more images;
deriving a position of a said light emitter and said shadow casting object from said pose of said imager and said known relative positions;
identifying a 3D orientation of a ray of illumination from the light emitter intersecting said shadow casting object and defining an edge of the shadow based on said pose of said imager and said known relative positions; and
ascertaining a 3D location of each of said two points from said 3D location of said intersection, a location of said shadow in said image and a location of each of said two points in said image.

US Pat. No. 10,136,969

METHOD AND SYSTEM FOR TOOTH RESTORATION

Alireza Tavassoli, Brook...

1. A method for denture restoration, the method comprising:a) generating a first set of digital information of a mouth cavity of a patient;
b) producing an orientation appliance from said first set of digital information, the orientation appliance comprising upper and lower portions that are adapted to a size and shape of the mouth cavity of the patient, and a movable part facilitates adjusting a position of the upper portion relative to the lower portion, and, thereafter, placing the orientation appliance in the mouth cavity of the patient;
c) generating a second set of digital information of said mouth cavity with said orientation appliance being placed within said mouth cavity of the patient;
d) producing a temporary restoration using said second set of digital information;
e) placing said temporary restoration within said mouth cavity of the patient and generating a third set of digital information of said mouth cavity with said temporary restoration, provided in step d), being placed within said mouth cavity of the patient; and
f) producing a final restoration using
said third set of digital information generated with said temporary restoration being placed within said mouth cavity of the patient.

US Pat. No. 10,136,968

DISPOSABLE SURGICAL INTERVENTION GUIDES, METHODS, AND KITS

ISETHCO LLC, San Diego, ...

1. A removable modular surgical guide assembly, comprising:a deformable casting medium, wherein the deformable casting medium defines an open treatment area when positioned on a dentiture of a subject;
a foundation plate circumscribing the open treatment area; and
a sensor array affixed to the foundation plate, the sensor array comprising a flexible circuit having at least two electromagnetic sensors, wherein the at least two sensors are positionable around the open treatment area at, or about at, a gumline of the dentiture of the subject,
wherein the foundation plate and the deformable casting medium are comprised of different materials, and the foundation plate is positioned in contact with the deformable casting medium.

US Pat. No. 10,136,967

DENTAL IMPLANT ABUTMENT COPINGS

Bicon, LLC, Boston, MA (...

1. A dental abutment coping for securing a dental prosthesis to a dental abutment, the dental abutment coping comprising:a body extending from a first end to a second end along a longitudinal axis, the body defining a cavity extending from an opening in the second end of the dental abutment coping, the body comprising:
an exterior surface adapted to be inserted into a corresponding interface cavity of the dental prosthesis;
a peripheral region of the second end, the peripheral region extending around the opening and comprising a beveled surface oriented towards the longitudinal axis at an angle relative to the longitudinal axis; and
an interior surface sized to accept a head of the dental abutment, the interior surface having a tapered interior region and an interface interior region, the interface interior region being between the peripheral region and the tapered interior region, and the tapered interior region defining an increasing internal diameter of the cavity between a distal end of the cavity and the interface interior region;
wherein the exterior surface includes
a tapered exterior region;
a flat exterior region parallel to the longitudinal axis;
wherein the tapered exterior region extends from the first end of the body to the flat exterior region, the tapered exterior region defining an increasing exterior diameter of the body along the length towards the second end, and
wherein the flat exterior region extends from the tapered exterior region to the beveled surface of the peripheral region of the second end.

US Pat. No. 10,136,966

ORTHODONTIC APPLIANCE

Dentbend BVBA, Liederker...

1. An orthodontic appliance comprising:a plurality of brackets, each bracket having a base for connection to a surface of a tooth within a row of teeth; and
a body configured to be coupled to each of said brackets, the body being provided with a plurality of connection elements arranged on the body, each connection element being configured to cooperate with a respective one of the plurality of brackets to form a connection between the body and the respective bracket,
wherein each connection element comprises a slot,
wherein each bracket comprises a locking element and a stem protruding from the base to connect the locking element to the base, the locking element being configured to be inserted into the slot of a respective connection element, the locking element being substantially disc-shaped and elongated in a primary axis of the respective tooth and having a larger diameter than the stem,
wherein the locking elements of the plurality of brackets and the slots of the plurality of connection elements define locking means for removably connecting the body to the plurality of brackets via the plurality of connection elements,
wherein the slot of each connection element is configured to fit around the locking element of the respective bracket, the slot comprising mating surfaces configured to form a mating engagement with the locking element of the respective bracket and at least one guiding surface configured to guide a top surface of the locking element into the slot, said at least one guiding surface running inward starting at a lower edge of the slot, the slot being a latching slot comprising a tip or protruding section at an interface between said at least one guiding surface and said mating surfaces,
wherein each connection element further comprises a first aperture through which the locking element of the respective bracket can be inserted into the slot and a second aperture configured to slide over the stem of the respective bracket,
wherein the stems of the plurality of brackets are configured so that a distance between the body and the row of teeth is sufficient for insertion and removal of the body and for cleaning of the brackets,
wherein the stem of each of the plurality of brackets is arranged on the base outside of a center of the base and a central axis of the stem is shifted with respect to a central axis of the base such that the stem is configured to define a position of the body that is shifted along the primary axis of the respective tooth with respect to a plane extending perpendicular to the primary axis of the respective tooth and through a center of the row of teeth.

US Pat. No. 10,136,965

CUSTOMIZED ORTHODONTIC BRACKET SYSTEM

3M Innovative Properties ...

1. A custom orthodontic bracket system comprising:a bracket body having a bracket slot;
a bracket bonding pad including a tooth-facing surface and a surface opposite the tooth-facing surface for bonding the bracket body to a specific 3-dimensional surface of a tooth of a predetermined patient, wherein the tooth-facing surface includes a contour that is a negative of and matches the 3-dimensional surface of the predetermined patient's tooth, and the opposite surface includes a contour that matches the 3-dimensional surface of the patient's tooth; and
an archwire positioned in the bracket slot forming a bracket slot-archwire interface and having a first cross-sectional dimension and a second cross-sectional dimension perpendicular to the first cross-sectional dimension, wherein a surface of the archwire or a major axis of the cross-section of the archwire is adapted to be oriented substantially parallel to the predetermined patient's tooth surface and to be canted with respect to the occlusal plane.

US Pat. No. 10,136,964

AUTOMATIC PLACEMENT OF PRECISION CUTS

Align Technology, Inc., ...

1. An orthodontic system for positioning a patient's teeth, comprising:a first patient removable orthodontic tooth positioning appliance having teeth receiving cavities shaped to receive and apply a resilient positioning force to a patient's teeth provided in one of an upper jaw and a lower jaw, the appliance comprising a hook configured to receive an orthodontic elastic band; and
a second patient removable orthodontic tooth positioning appliance having teeth receiving cavities shaped to receive and apply a resilient positioning force to a patient's teeth provided in the other of the upper jaw and the lower jaw, the appliance comprising a cutout operable to expose an orthodontic elastic band receiving member wherein the cutout is operable to be disposed over a tooth, is shaped to extend between a first point of a gingival line of the tooth and a second point of the gingival line of the tooth, and has a gingival-facing surface arrangeable between the elastic band receiving member and an occlusal surface of the tooth.

US Pat. No. 10,136,963

SYSTEM AND METHOD FOR INTRODUCING PHOTOSENSITIVE DYES VIA AN INSERT INTO A ROOT CANAL IN A TOOTH, METHOD FOR PRODUCING SAID DYE IMPREGNATED INSERT AND METHOD OF USING SAID DYE-IMPREGNATED INSERT

1. A bactericidal insert for introduction into a canal in a tooth during a root canal procedure, said insert comprising a carrier having a plurality of pores or interstices having been impregnated with a liquid photosensitive dye so that said dye enters said pores or interstices and then said carrier with said liquid photosensitive dye forms a dye-impregnated carrier, said dye-impregnated carrier being configured for insertion within the canal of the tooth and also, the dye can be wet or dried and, if dried, configured to be wetted to dissolve said dye to produce a liquefied dye, said liquefied dye being activatable to produce singlet oxygen or free radicals within said canal when irradiated by light from outside of the tooth;wherein said insert is configured so that a wetting agent can be added thereto to wet said dry dye-impregnated carrier and wherein said insert is packaged in a package with said wetting agent.

US Pat. No. 10,136,962

MULTI-PLANAR PRE-CURVED ROTARY ENDODONTIC FILE

Dentsply Sirona, Inc., Y...

1. An improvement endodontic instrument configured for use in a rotary hand piece and having a working length made of a shape memory material and including a plurality of flutes forming a cutting edge, the improvement comprising:the working length including
a straight non-apical portion whose central longitudinal axis is a central rotational axis of the endodontic instrument and
a pre-curved apical portion whose central longitudinal axis does not lie along the central rotational axis of the endodontic instrument,the pre-curved apical portion beginning at about one-third to one-quarter of the working length as measured from a tip end of the endodontic instrument and ending at the tip end, the pre-curved apical portion having at least three curvatures including at least one curvature that spirals about the central rotational axis of the endodontic instrument, the at least one curvature having a radius of curvature “R” which places the tip end at an angle in a range of about 300 to 750 relative to the central rotational axis.

US Pat. No. 10,136,961

DENTIST TOOL

Viax Dental Technologies,...

1. An overlay for guiding a dental cutting tool defining a longitudinal axis in the removal of predetermined tooth structure from a tooth to be treated, the overlay comprising:an inner surface having a shape and dimensions corresponding to and configured for contacting a contact region on and extending at least partially around either of or both an outer surface of the tooth to be treated and an outer surface of a neighboring tooth of the tooth to be treated such that the inner surface remains releasably fixed to the contact region and in the same position relative to the tooth to be treated upon application of pressure to the overlay during guiding of the dental cutting tool in normal use of the overlay;
a first guiding edge extending through a thickness of the overlay including through the inner surface, the first guiding edge having a contour corresponding to any one or any combination of horizontal, vertical, and tilt movements to be followed by the dental cutting tool in a direction transverse to the longitudinal axis of the dental cutting tool; and
a second guiding edge extending through the thickness of the overlay including through the inner surface, the second guiding edge being spaced apart from the first guiding edge and having a contour corresponding to any one or any combination of the horizontal, vertical, and tilt movements to be followed by the dental cutting tool,
wherein the inner surface of the overlay is configured for extending between top and bottom portions of the respective one or both of the outer surface of the tooth to be treated and the outer surface of the neighboring tooth of the tooth to be treated to which the inner surface corresponds and on which the inner surface is configured for contacting a contact region, the inner surface of the overlay being configured for contacting the respective bottom portion or portions at a respective location or respective locations adjacent to a gingiva of the patient.

US Pat. No. 10,136,960

HAND-HELD ELECTROSURGICAL INSTRUMENT

1. A hand-held instrument, comprising:a handle portion;
an electrosurgical electrode supportably interconnected to and extending distally away from a first end of said handle portion in a first direction;
a signal cable, extending proximally from a proximal end of the handle portion to an interconnected coupler end that is provided to interface with an electrosurgical generator, for transmission of electrosurgical signals to the electrosurgical electrode via the signal cable;
at least one electrically-powered light source, interconnected to said handle portion, for emitting light in said first direction to illuminate a volume extending along the electrosurgical electrode from said first end of the handle portion to a distal end of the electrosurgical electrode;
at least one battery, disposed remotely from said handle portion, to provide electrical power to said at least one light source as a DC signal;
an electrical cable, extending proximally from the proximal end of the handle portion to an interconnected battery module for supporting said at least one battery, to provide said electrical power from said at least one battery to said at least one light source via the electrical cable; and
a switch, interconnected to said handle portion and in electrical communication with said at least one battery by said electrical cable, for selective activation of said at least one light source by said electrical power form said at least, one battery.

US Pat. No. 10,136,959

ENDOLUMENAL OBJECT SIZING

Auris Health, Inc., Redw...

1. A method for sizing an object positioned within a patient, comprising:navigating an elongate body to a location within the patient and proximate to the object, the elongate body comprising an imaging sensor for capturing images of the object;
capturing sequential images of the object with the imaging sensor;
navigating the elongate body into at least one of a different orientation and a different position during the capture of the sequential images;
determining orientations and positions of the elongate body during the capture of the sequential images based on a set of robot data;
comparing the orientation and position of the elongate body determined based on the set of robot data for at least one captured sequential image to the orientation and position determined based on the set of robot data for at least another captured sequential image; and
analyzing, with a processor, the sequential images of the object and the comparison of the set of robot data to estimate a size of the object.

US Pat. No. 10,136,958

TISSUE PROTECTOR AND METHOD OF USE

Amendia, Inc., Marietta,...

1. A tissue protector comprises:a body structure having a first proximal end and a second distal end with a longitudinal extending thin flexible web with a pair of rigid or solid rails between said ends, the body structure having an unconstrained first shape with a length and a width configured to form the tissue protector, the body structure being a solid single piece of material compressible along the entire length of the web and configured to wrap or roll about a longitudinal axis of the body structure to a smaller constrained second shape sized to fit into a lumen of a cannula, the pair of rigid rails being longitudinal extending rails extending longitudinally along the length of web on each side of the web wherein the two rails of the body structure are parallel enlarged longitudinally extending projections extending the entire length of the body structure in both the constrained second shape and unconstrained first shape, the web having a constant width and being interposed between said parallel longitudinally extending rails to form a shallow channel extending the entire length from the first proximal end to the second distal end in the unconstrained first shape and wherein the body structure when placed inside the lumen of the cannula is configured to be positioned between two adjacent vertebral bodies and is configured to return to the unconstrained first shape when the cannula is withdrawn from between the two adjacent vertebral bodies while leaving the body structure between the two adjacent vertebral bodies, the web and the two rails are configured to shield a nerve root wherein the unconstrained first shape of the web is sized with the constant width to receive a spinal implant for insertion at the first proximal end in the shallow channel sliding along the web between the rigid rails to the second distal end between the two vertebral bodies as the web between the two rigid rails forms a guide for the spinal implant and a shield for the nerve root as the spinal implant is inserted.

US Pat. No. 10,136,956

APPARATUS AND METHOD FOR ROBOT-ASSISTED SURGERY AS WELL AS POSITIONING DEVICE

avateramedical GmbH, (DE...

1. An apparatus for robot-assisted surgery, comprisingan instrument unit having a surgical instrument with an instrument shaft, a proximal end of which is passable through a body orifice of a patient to a target area defined by coordinates of a coordinate system of the apparatus,
a positioning device emitting light as a beam of rays,
at least one coupling unit of a manipulator arm, to which optionally the positioning device or the instrument unit is connectable,
wherein, when connecting the positioning device to the coupling unit, a position of a central axis of the beam of rays emitted by the positioning device corresponds with a position of the longitudinal axis of the instrument shaft of the instrument unit connected to the coupling unit instead of the positioning device,
a control unit,
which, when the positioning device is connected to the coupling unit, determines an amount of a distance vector, which is orthogonal to the central axis, between the central axis and the target area defined by the coordinates,
which generates a first control information when the amount of the determined distance vector is less than or equal to a first preset value, and
comprising an output unit which outputs a signal dependent on the first control information.

US Pat. No. 10,136,955

ROBOTIC DEVICE FOR IMAGE-GUIDED SURGERY AND INTERVENTIONS

University of Houston Sys...

1. A flexible actuation transmission line for a medical-intervention robot, comprising:a channel containing solid media disposed inside that mechanically links a powering unit to an instrument or a component of the robot linked to the instrument;
axial movement of said media inside the channel powered by the said powering unit actuates said instrument or actuated component; and
gates which selectively block the channel.

US Pat. No. 10,136,954

SURGICAL TOOL SYSTEMS AND METHOD

Globus Medical, Inc., Au...

1. A surgical robot system comprising:a robot having a robot base, a robot arm coupled to the robot base, and an end-effector coupled to the robot arm, the end-effector including a plurality of tracking markers detectable by at least one camera;
a plurality of omni-directional wheels affixed to the robot base allowing multiple-axis movement of the robot;
a plurality of sensors for detecting a desired movement of the robot base; and
a control system responsive to the plurality of sensors for controlling the multiple-axis movement of the robot by actuating two or more of the plurality of omni-directional wheels.

US Pat. No. 10,136,953

COMPUTER ASSISTED SURGERY APPARATUS AND METHOD OF CUTTING TISSUE

1. A computer assisted surgery apparatus, the apparatus comprising:a surgical instrument having an intervention member to cut tissue of a body part of a patient;
a control unit arranged to automatically control position and orientation of the intervention member of the surgical instrument in relation to the body part of the patient with regard to a predefined osteotomic line on the body part of the patient; and
a tracking device arranged to track a position and orientation of the body part of the patient,
wherein the surgical instrument comprises an optical monitoring system being fixedly mounted in relation to the intervention member of the surgical instrument, the optical monitoring system being arranged to continuously detect positions of marks applied to the body part of the patient, and
wherein the control unit is arranged to adjust position or orientation, or position and orientation of the intervention member of the surgical instrument when a predefined deviation of the positions of the marks is detected.

US Pat. No. 10,136,952

SOFT TISSUE BALANCING IN ARTICULAR SURGERY

Zimmer, Inc., Warsaw, IN...

1. A robot-aided knee arthroplasty system comprising:an end effector of a robotic arm to couple to a femur of a knee joint with a soft tissue balancing component that permits the femur to freely rotate while coupled to the end effector;
a robotic controller to:
cause the robotic arm to apply a pulling force to the femur using the end effector to increase a gap distance between the femur and a tibia of the knee joint;
measure the gap distance between the femur and the tibia and a rotation of the femur as the robotic arm applies the pulling force to the femur using the end effector;
determine whether a gap configuration of the knee joint is equal to a predetermined gap configuration at the measured gap distance; and
store, when the gap configuration is equal to the predetermined gap configuration at the measured gap distance, the rotation of the femur as a target femoral implant rotation; and
a surgical planning system to plan a position and orientation of a resection of the femur for implantation of a femoral implant at the target femoral implant rotation.

US Pat. No. 10,136,951

SYSTEMS, METHODS, APPARATUSES, AND COMPUTER-READABLE MEDIA FOR IMAGE GUIDED SURGERY

InnerOptic Technology, In...

1. A method of displaying a perspective view of an image, the method comprising:receiving emplacement data associated with a physical medical device;
determining an emplacement of a medical image slice based at least in part on the emplacement data;
determining a perspective view of the medical image slice in a virtual 3D space based at least in part on a relative orientation of the physical medical device with respect to an expected location of a user, wherein the expected location of the user is a fixed location in front of one or more displays; and
causing the one or more displays to display in real-time the perspective view of the medical image slice in the virtual 3D space.

US Pat. No. 10,136,950

PATIENT-MATCHED SURGICAL COMPONENT AND METHODS OF USE

Biomet Manufacturing, LLC...

1. A method of performing a surgical procedure aided by a surgical navigation system, comprising:generating a representative model of an anatomical feature from an image of a patient's anatomy;
using the model to make a virtual surgical component;
installing the virtual surgical component on the representative model of the anatomical feature by mating the surface of the component with the anatomical feature in the predefined spatial relationship;
tracking movement of the anatomical feature with a tracking system when a physical surgical component corresponding to the virtual surgical component is moved within a measurement field of the tracking system;
tracking movement of a surgical cutting instrument with the tracking system;
displaying the representative model and the surgical cutting instrument on a display of the surgical navigation system; and
guiding the surgical cutting instrument on the display to verify a cutting plane of the surgical cutting instrument relative to the anatomical feature.

US Pat. No. 10,136,949

GATHERING AND ANALYZING DATA FOR ROBOTIC SURGICAL SYSTEMS

Ethicon LLC, Guaynabo, P...

1. A system for facilitating performance of surgical procedures, comprising:a memory configured to store a model profile indicating a suggested setup of a model robotic surgical system for a model surgical procedure, wherein the suggested setup includes a recommendation of an attachment location of each of a plurality of moveable arms of a robotic surgical system to a stationary item, the robotic surgical system to be used in performance of a surgical procedure after the storing of the model profile, wherein the suggested setup includes a recommendation of an initial position of each of the arms of the robotic surgical system, and wherein the arms are each configured to couple to one of a plurality of surgical instruments; and
a processor configured to, after the plurality of movable arms have been attached to the stationary item in accordance with the recommendation of the attachment location, drive one or more motors of the robotic surgical system to be used in performance of the surgical procedure on a patient and thereby move one or more of the plurality of movable arms such that the one or more of the plurality of movable arms are automatically positioned in accordance with the recommendation of the initial position of each of the arms;
wherein the processor is also configured to:
receive movement data indicative of movement of the arms during performance of the surgical procedure on the patient,
after performance of the surgical procedure, modify the model profile based on the received movement data, and
store the modified model profile in the memory.

US Pat. No. 10,136,948

SYSTEM FOR IMAGE-BASED ROBOTIC SURGERY

MAKO Surgical Corp., For...

1. A robotic surgery method, comprising:coupling a first element of a fluoroscopic imaging system to a first robotic arm fixed relative to an operating room, the first robotic arm comprising a mounting fixture configured to be interchangeably coupled to a surgical tool and the first element of the fluoroscopic imaging system;
mounting a second element of the fluoroscopic imaging system in a position and orientation relative to the first element such that a targeted patient tissue structure may be positioned between the first and second elements of the fluoroscopic imaging system;
wherein the fluoroscopic imaging system comprises a source element and a detector element;
wherein the first element is the source element and second element is the detector element, or the first element is the detector element and the second element is the source element;
utilizing a sensing system and one or more sensing elements coupled to each of the first and second elements of the fluoroscopic imaging system to determine a relative spatial positioning between each of the first and second elements of the fluoroscopic imaging system.

US Pat. No. 10,136,947

SURGICAL PATIENT SIDE CART WITH DRIVE SYSTEM AND METHOD OF MOVING A PATIENT SIDE CART

INTUITIVE SURGICAL OPERAT...

1. A teleoperated surgical system cart, the cart comprising:a base;
a surgical instrument support structure extending from the base, the surgical instrument support structure being adjustable to different configurations, the surgical instrument support structure being configured to be removably coupled with a surgical instrument;
a steering interface configured to be grasped by a user;
a sensor mechanism configured to detect a force applied to the steering interface; and
a drive system comprising:
a control module operably coupled to receive an input from the sensor mechanism in response to the force applied to the steering interface and information about a configuration of the surgical instrument support structure, the control module being programmed with a model correlating the received input from the sensor mechanism and the information about the configuration of the surgical instrument support structure with a movement output command, the control module being configured to output the movement output command in response to the received input from the sensor mechanism and in response to the received information about the configuration of the surgical instrument support structure; and
a driven wheel mounted to the base and configured to impart wheeled motion to the cart in response to the movement output command.

US Pat. No. 10,136,946

SURGICAL ANTENNA STRUCTURE

CREO MEDICAL LIMITED, Ch...

1. A surgical instrument comprising:a surgical spatula comprising a flat paddle and a coaxial cable extending away from a first end thereof, wherein the flat paddle contains a planar microwave conveying structure connected to the coaxial cable, the planar microwave conveying structure being formed from a sheet of a first dielectric material having first and second conductive layers on opposite surfaces thereof, and being open along a side of the flat paddle which extends away from the first end to permit a microwave radiation field to be emitted from that side;
an endoscope; and
a microwave generator connected to deliver microwave energy to the spatula via the coaxial cable, which is arranged to run through an instrument channel of the endoscope,
wherein the coaxial cable comprises an inner conductor, an outer conductor coaxial with the inner conductor, and a second dielectric material separating the outer and inner conductors,
wherein the inner and outer conductors extend beyond the second dielectric to overlap opposite surfaces of the flat paddle to electrically contact the first conductive layer and second conductive layer respectively, and
wherein the first conductive layer is spaced from the first end of the flat paddle to electrically isolate the outer conductor from the first conductive layer.

US Pat. No. 10,136,945

ABLATION CATHETER WITH LIGHT-BASED CONTACT SENSORS

BIOSENSE WEBSTER (ISRAEL)...

1. A catheter, comprising:an elongated body;
an expandable element at a distal end of the elongated body;
at least one electrode disposed on the expandable body;
at least one contact sensor disposed on the expandable element and adjacent to the at least one electrode;
at least one light emitting element electrically connected to the contact sensor; and
a light sensor, the light sensor configured to receive a light signal from the at least one light emitting element.

US Pat. No. 10,136,944

SYSTEMS AND METHODS FOR TREATING CANCER AND/OR AUGMENTING ORGAN FUNCTION

AUTONOMIX MEDICAL, INC., ...

1. A composition, for use in blocking at least one of one or more nerves and one or more lymphatic ducts, comprising:a neurolytic agent;
a sympathetic nerve selective neurotoxin for ablating a region surrounding a nutrient artery of a bone; and
an inflammatory agent;
wherein the neurolytic agent comprises ethanol;
wherein the inflammatory agent comprises one or more of poly(lactic-co-glycolic acid) (PLGA), polysaccharides, collagen, silica particles, carbon micro or nanoparticles, and microbeads; and
wherein the sympathetic nerve selective neurotoxin comprises at least one of 6-hydroxydopamine, ?-conotoxin, and bungarotoxin.

US Pat. No. 10,136,943

ELECTROSURGICAL SYSTEM

COSMAN INSTRUMENTS, LLC, ...

1. A system for tissue ablation including an electrosurgical generator, a cannula and an electrode, the cannula including an elongated shaft having a proximal end and a distal end, the cannula shaft including an electrically-conductive active tip distal to an electrically-insulated cannula shaft portion, the cannula shaft including a lumen extending from a proximal opening at the proximal end of the shaft to an exit opening within a distal portion including the distal end of the cannula shaft, the cannula including a cannula hub at the proximal end of the shaft of the cannula, the electrode including an electrode shaft having a proximal end and a distal end, the electrode shaft including an electrically-conductive active tip distal to an electrically-insulated electrode shaft portion, the electrode including an electrode hub at the proximal end of the shaft of the electrode, the electrode conducting a first electrical potential from the electrosurgical generator to the electrode active tip, wherein the electrode and the cannula are configured to be assembled by inserting the electrode shaft into the cannula lumen through the proximal opening such that engagement of the electrode hub with the cannula hub conducts a second electrical potential from the electrosurgical generator to the cannula active tip via the electrode, the electrode active tip and the electrically-insulated electrode shaft portion extend out of cannula lumen through the exit opening, the electrode active tip is electrically insulated from the cannula active tip within the assembly of the electrode and the cannula, and the assembly of the electrode and the cannula is configured to conduct electrical current through bodily tissue between the cannula active tip and the electrode active tip.

US Pat. No. 10,136,942

ELECTROSURGICAL SYSTEM

COSMAN INSTRUMENTS, LLC, ...

1. A system for tissue ablation including an electrosurgical generator, a cannula and an electrode, the cannula including an elongated shaft having a proximal end and a distal end, the cannula shaft including an electrically-conductive active tip distal to an electrically-insulated cannula shaft portion, the cannula shaft including a lumen extending from a proximal opening at the proximal end of the shaft to an exit opening within a distal portion including the distal end of the cannula shaft, the cannula including a cannula hub at the proximal end of the shaft of the cannula, the electrode including an electrode shaft having a proximal end and a distal end, the electrode shaft including an electrically-conductive active tip distal to an electrically-insulated electrode shaft portion, the electrode including an electrode hub at the proximal end of the shaft of the electrode, the electrode conducting a first electrical potential from the electrosurgical generator to the electrode active tip, wherein the electrode and the cannula are configured to be assembled by inserting the electrode shaft into the cannula lumen through the proximal opening such that engagement of the electrode hub with the cannula hub conducts a second electrical potential from the electrosurgical generator to the cannula active tip via the electrode, the electrode active tip and the electrically-insulated electrode shaft portion extend out of cannula lumen through the exit opening, the electrode active tip is electrically insulated from the cannula active tip within the assembly of the electrode and the cannula, and the assembly of the electrode and the cannula is configured to conduct electrical current through bodily tissue between the cannula active tip and the electrode active tip.

US Pat. No. 10,136,941

SURGICAL INSTRUMENT AND METHOD OF CREATING THE SAME

JSTONE INC., Mundelien, ...

1. A surgical instrument comprising:a handle portion;
a cylindrical hollow tube secured to the handle portion the cylindrical hollow tube having a first end and a second end wherein the second end of the cylindrical hollow tube is secured to the handle portion;
a clevis unit secured within a cylindrical covering wherein the cylindrical covering has a first end and a second end and wherein second end of the cylindrical covering is located adjacent to the first end of the cylindrical hollow tube;
a first blade and a second blade wherein a portion of the first blade and a portion of the second blade are secured within the clevis unit;
a rubber seal partially covered by the first end of the cylindrical hollow tube and partially covered by the second end of the cylindrical covering;
a first end of the first blade and a second end of the first blade;
a first end of the second blade and a second end of the second blade; and
wherein the second end of the first blade and the second end of the second blade do not extend outside of a circumference of the clevis unit at any time, while the first end of the first blade and the first end of the second blade extend outside of the circumference of the clevis unit.

US Pat. No. 10,136,940

APPARATUS FOR PERFORMING AN ELECTROSURGICAL PROCEDURE

COVIDIEN LP, Mansfield, ...

1. A forceps, comprising:a housing;
at least one shaft extending from the housing, the at least one shaft defining a longitudinalaxis;an end effector assembly operatively connected to a distal end of the at least one shaft having first and second jaw members, at least one of the first and second jaw members pivotable relative to the other from an open position wherein the first and second jaw members are disposed in spaced relation relative to one another, to a clamping position wherein the first and second jaw members cooperate to grasp tissue therebetween under a sealing pressure;
a pivot pin providing an axis of pivot for the pivotable jaw member; and
a monolithic jaw insert operably disposed within at least one of the first and second jaw members, the jaw insert defining an opening configured to securely house the pivot pin, the jaw insert including a moveable member configured to engage a cam pin and configured to provide a camming force to the cam pin and a portion of the sealing pressure to the jaw members when the first and second jaw members are in the clamping position.

US Pat. No. 10,136,939

ENERGY DELIVERY DEVICE HAVING A TRANSLATING OUTER SHEATH

Ethicon LLC, Guaynabo, P...

1. A surgical device, comprising:an end effector having a proximal end, a distal end, and an elongate shaft extending between the proximal and distal ends, the distal end being configured to deliver energy;
a cannulated outer sheath having a proximal end, a distal end, and an intermediate length extending between the proximal and distal ends, the end effector being disposed within the outer sheath, and the distal end having a plurality of holes formed in an outer surface thereof, the holes being in fluid communication with the remainder of the cannulated outer sheath to provide at least one of suction and irrigation to a surgical site;
a nozzle coupled to the proximal end of the outer sheath and configured to translate along a longitudinal axis of the cannulated outer sheath;
a carrier coupled to the nozzle;
a handle portion coupled to the proximal end of the end effector, the handle portion having a switch,
wherein the carrier is coupled to the switch such that operation of the switch distally advances the carrier to distally advance the nozzle with respect to the handle portion to selectively cover the distal end of the end effector with the distal end of the outer sheath, and operation of the switch proximally retracts the carrier to proximally retract the nozzle with respect to the handle portion to selectively expose the distal end of the end effector.

US Pat. No. 10,136,938

ELECTROSURGICAL INSTRUMENT WITH SENSOR

Ethicon LLC, Guaynabo, P...

1. An apparatus for operating on tissue, the apparatus comprising:(a) a body;
(b) a shaft extending distally from the body;
(c) an end effector configured to receive energy from an energy source, wherein the end effector comprises:
(i) a first jaw, and
(ii) a second jaw, wherein the second jaw is pivotable relative to the first jaw to transition the end effector from an open configuration to a closed configuration, wherein the first jaw and second jaw define a closure gap between each other when the end effector is in the closed configuration;
(d) a first movable member operatively coupled with the second jaw, wherein the first movable member is configured to move in response to pivoting of the second jaw relative to the first jaw; and
(e) a sensor, wherein the sensor includes a second movable member configured to be engaged by the first movable member, wherein the second movable member is moveable from a first position to a second position in response to movement of the first moveable member when the end effector transitions from the open configuration to the closed configuration,
wherein the sensor is operable to detect that the end effector is in the closed configuration when the second movable member moves to the second position, wherein the sensor is in communication with the energy source, wherein the sensor is operable to communicate a signal to the energy source when the sensor detects the end effector in the closed configuration.

US Pat. No. 10,136,937

ELECTROSURGICAL SYSTEM

COSMAN INSTRUMENTS, LLC, ...

1. A system for tissue ablation including a cannula and an electrode, the cannula including an elongated shaft having a proximal end and a distal end, the cannula shaft including an electrically conductive active tip distal to an electrically insulated cannula shaft portion, the cannula shaft including a lumen extending through the entire length of the cannula shaft from a proximal opening at the proximal end of the shaft to a distal portion of the shaft, the cannula including a side opening to the lumen through the side of the cannula shaft wall, the cannula shaft being substantially stiff and including a bend configured so that the electrode shaft exits the side opening of the lumen when the electrode shaft is inserted into the cannula lumen through the proximal opening, the electrode including an electrode shaft having a proximal end and a distal end, the electrode shaft including an electrically conductive portion, the electrode shaft being substantially straight and stiff, the electrode and cannula being configured to be assembled into a first assembly wherein the electrode shaft is inserted into the cannula lumen through the proximal opening, the electrically conductive portion of the electrode shaft extends out of the cannula lumen through the side opening, and the first assembly is configured to conduct radiofrequency current from a radiofrequency generator to bodily tissue through both the active tip of the cannula and the electrically conductive portion of the electrode shaft.

US Pat. No. 10,136,936

DIAGNOSIS AND TREATMENT DEVICES AND RELATED METHODS OF USE

Boston Scientific Scimed,...

1. A method of treating a patient, comprising:applying stimulus at a stimulation location;
measuring an effect of the stimulus on a lung airway of the patient, the lung airway being spaced apart from or distal to the stimulation location;
selecting a treatment location in the lung airway distal to the stimulation location when the measured effect of the stimulus on the lung airway is greater than a threshold value; and
applying therapeutic energy to tissue at the treatment location.

US Pat. No. 10,136,935

DEVICE FOR THE CONTROLLED REMOVAL OF OSSEOINTEGRATED IMPLANTS AND IMPROVED OSSEODISINTEGRATABLE IMPLANTS

1. A medical device for releasing an implant from a bone of a patient to which the implant adheres to, the medical device comprising:a heating/cooling device configured to produce or release heating energy and/or a cooling agent to heat and/or cool the implant;
a controlling device configured to control the heating/cooling device, wherein the controlling device comprises a database storing information and controls the heating/cooling device based on the information stored in the database;
wherein the database comprises:
implant information; and
information defining a temperature, a temperature curve, a heating time, a cooling time, and a frequency of heating and/or cooling suitable to effect osseodisintegration of the implant based on the implant information;
a coupling device configured to releasably connect to the implant while the implant adheres to the bone of the patient, wherein the coupling device is configured to transfer the heating energy and/or the cooling agent produced or released by the heating/cooling device to the implant; and
an input device operably linked with the controlling device, wherein the input device is configured to receive a parameter from an operator operating the medical device, wherein the parameter:
(i) defines a type, dimension, mass, surface structure and/or material of said implant; and/or
(ii) defines an expected amount of osseointegrated surface on the implant; and/or
(iii) defines an amount and/or duration of the heating and/or cooling; and/or
(iv) defines an expected position or region of the osseointegrated surface on the implant; and/or
(v) is selected from the group consisting of
(a) information defining a type, dimensions, mass, surface structure and/or material of the implant or a cavity geometry within the implant;
(b) information defining a form of the coupling device or information defining a thermal conductivity of the coupling device;
(c) information defining a surface of the implant which is osseointegrated;
(d) information defining a type of heating energy and/or cooling agent to be used or information defining an amount of heating energy and/or cooling agent necessary to reach osseodisintegration of an implant as defined in (a); and
(e) information for controlling the heating/cooling device to heat or cool the implant to achieve osseodisintegration of bone material contacting the implant or located within a distance of less than a predefined distance from the surface of said implant;
and/or
(vi) defines bone density of the bone contacting or surrounding the implant; and/or
(vii) defines a date on which the implant was implanted into the patient; and/or
(viii) defines an age of the patient.

US Pat. No. 10,136,934

BONE TREATMENT SYSTEMS AND METHODS

DFine, Inc., South Jorda...

1. A bone treatment system comprising:a bone fill material injector configured to be at least partially introduced into a bone;
a handle comprising a flow passageway for a flow of bone fill material, and a thermal energy emitter disposed within the handle, the handle operatively coupled to the injector, the thermal energy emitter configured for delivering energy to the flow of the bone fill material within the flow passageway, wherein the flow passageway extends through the handle in a first direction and curves and extends in a second direction, substantially perpendicular to the first direction, forming a non-linear pathway through the handle, and wherein the thermal energy emitter at least partially encompasses a portion of the flow passageway and is disposed along the second direction near an outlet of the handle;
a sensor system, wherein the sensor system comprises a sensor configured to measure a rate of the flow of the bone fill material within the flow passageway; and
an electronic controller configured to modulate the delivery of the energy from the thermal energy emitter to the flow of the bone fill material based at least in part on a rate measurement from the sensor to achieve a desired bone fill material viscosity.

US Pat. No. 10,136,933

ORTHOPEDIC CONNECTIONS

Zimmer, Inc., Warsaw, IN...

1. An orthopedic connection connecting a first orthopedic component to a second orthopedic component, the orthopedic connection comprising:a male-type connecting member projecting from the first orthopedic component and having a general longitudinal axis; and
a female-type aperture situated in the second orthopedic component and in forcible receipt of the male-type connecting member so as to create a securing zone in which a portion of the male-type connecting member makes forcible contact with walls of the female-type aperture and maintains said forcible contact to securely connect the first orthopedic component to the second orthopedic component,
wherein the male-type connecting member includes a distal longitudinal segment and a proximal longitudinal segment,
wherein in a single reference plane that includes said general longitudinal axis the distal longitudinal segment extends in a linear fashion and the proximal longitudinal segment extends in a curvilinear fashion, wherein the distal longitudinal segment adjoins the proximal longitudinal segment at a first location along the male-type connecting member,
wherein the portion of the male-type connecting member that makes forcible contact with walls of the female-type aperture and maintains said forcible contact encompasses the first location and extends distally and proximally of the first location along the male-type connecting member so that the portion includes a part of the distal longitudinal segment and a part of the proximal longitudinal segment,
wherein the female-type aperture being in forcible receipt of the male-type connecting member includes a first non-securing zone in which the distal longitudinal segment of the male-type connecting member is present but the walls of the female-type aperture are not contacted by the distal longitudinal segment, the first non-securing zone located distally of the securing zone,
wherein the female-type aperture being in forcible receipt of the male-type connecting member also includes a second non-securing zone in which the proximal longitudinal segment of the male-type connecting member is present but the walls of the female-type aperture are not contacted by the proximal longitudinal segment, the second non-securing zone located proximally of the securing zone.

US Pat. No. 10,136,932

SPINAL PLATE AND DISTRACTION/COMPRESSION PIN SYSTEM

Camber Spine Technologies...

1. A cervical fixation plate and distraction pin system comprisingtwo or more distraction pins, and
a cervical fixation plate comprising
two or more boreholes for insertion of screws to position and secure the plate on the vertebral surfaces, and
two or more slots for placement of the two or more distraction pins,
wherein one of the slots is located at the inferior end of the plate and another of the slots is located at the superior end of the plate,
wherein each of the slots comprises two parallel straight side walls, and each of the slots is elongated along a longitudinal axis extending along a centerline of the plate, and wherein at least a portion of each of the side walls is ridged and contains a plurality of teeth, wherein the teeth are configured to mate with and secure the plate to a respective one of the pins and are configured to create and maintain compression across a disc space prior to and during securing of the plate on the vertebral surfaces,
wherein two of the boreholes are aligned along an axis substantially parallel to the longitudinal axis, the two boreholes disposed laterally with respect to each of the slots, and
wherein each pin comprises a threaded bone entry end and a ridged portion configured to retain the pin in the respective one of the two or more slots to secure the plate to the vertebral surfaces before attaching the screws, and wherein each pin is configured for removal from the respective one of the two or more slots.

US Pat. No. 10,136,931

BONE FIXATION DEVICE AND METHOD

1. An apparatus for fixation of a fractured bone, comprising:an elongated fixation plate having a longitudinal axis adapted to extend along a long axis of the fractured bone and including a first portion extending along the longitudinal axis of the fixation plate adapted for attachment to a first fragment of the fractured bone and a second portion extending in an opposite direction from the first portion along the longitudinal axis of the plate adapted for attachment to a second fragment of the fractured bone such that the fixation plate is adapted to extend across a fracture between the first fragment and the second fragment of the fractured bone;
a rotational member having a body and a first tab and a second tab extending outwardly and bending in a direction away from a plane of the body; and
a fastener for attaching the body of the rotation member to the elongated fixation plate;
wherein the tabs extending outwardly from the body are adapted for engaging the fractured bone to apply force to the first and second fragments transversely across opposite sides of the fractured bone to produce a torque across the fracture.

US Pat. No. 10,136,930

FLEXIBLE FASTENING DEVICE FOR INDUSTRIAL USE

1. A flexible fastening device to secure two components having curved or misaligned entry paths adjacent one another, said flexible fastening device being a rigid material and having:a body, said body having a length and a diameter, said length to diameter aspect ratio being at least 2, and multiple segments,
one of said multiple segments being a leading segment,
at least one of said multiple segments being a hollow segment;
at least two sinuous slots along at least a portion of said hollow segment to form at least one flexible segment, a first of said at least two sinuous slots extending along a first portion of said hollow segment and a second of said at least two sinuous slots extending along a second portion of said hollow segment,
one of said multiple segments being a trailing segment having a receiving area to receive a rotational force device.

US Pat. No. 10,136,929

FLEXIBLE BONE IMPLANT

IntraFuse, LLC, Logan, U...

1. A bone implant comprising an elongate body having a distal portion and a proximal portion spaced longitudinally relative to a longitudinal axis, wherein:the proximal portion comprises:
a non-threaded outer surface; and
a fully-bounded transverse bore passing through the proximal portion from a first fully-bounded opening in the non-threaded outer surface to a second fully-bounded opening in the non-threaded outer surface; and
the distal portion comprises a helical distal thread formed thereon, the helical distal thread having a major diameter, a minor diameter, and a pitch, the helical distal thread being operable to bend as it is threaded into a bone to follow a curved path, the helical distal thread having a bending stiffness lesser than a bending stiffness of the proximal portion,
wherein a ratio of a bending stiffness of the proximal portion to the bending stiffness of the distal portion is in the range of 2:1 to 20:1.

US Pat. No. 10,136,928

ROD LINK REDUCER

Globus Medical, Inc., Au...

1. A rod link reducer assembly comprising:a manipulator rod having a first end, a second end, and an elongate body extending along a body axis between the first end and the second end;
a post extending outwardly from the rod; and
a rod manipulating joint comprising:
an elongate joint rod extending along a joint rod axis;
a first coupling clamp disposed along the joint rod, the first coupling clamp releasably connectable to the post;
a second coupling clamp disposed along the joint rod adjacent to and rotatable about the joint rod relative to the first coupling clamp, the second coupling clamp releasably connectable to a second post; and
a first biasing member adapted to bias the second clamp against the first clamp,
at least two screw assemblies, a construct adapted to extend between the at least two screw assemblies,
wherein the second end of the manipulator rod comprises a tip, the tip comprising a receiver adapted to releasably secure the construct therein and a receiver axis extending orthogonally to the body axis,
wherein the receiver further comprises a securing member to releasably secure the construct to the receiver, the securing member extending at an angle oblique to the receiver axis, and
wherein the securing member comprises a set screw engaged with a threaded passage and a retainer pin located in the passage to prevent removal of the set screw from the passage.

US Pat. No. 10,136,926

EXPANDABLE SPINAL FIXATION SYSTEM

Globus Medical, Inc., Au...

1. An expandable spinal fixation system comprising:an expandable barrel assembly having:
an upper barrel half having a distal end and a proximal end, wherein the proximal end of the upper barrel comprises a slot formed therein;
a lower barrel half having a distal end and a proximal end, wherein the proximal end of the lower barrel comprises a projection portion configured to be received in the slot; and
a securing assembly having a plate adapted to bias the projection against the upper barrel proximal end and a securing member adapted to releasably bias the plate against the projection, and wherein, when the securing member biases the plate against the projection, the lower barrel half is fixed relative to the upper barrel half; and
a fixed barrel assembly having a body sized to fit between the upper barrel half and the lower barrel half, wherein the body extends along a longitudinal axis,
wherein the upper barrel half is capable of moving with respect to the lower barrel half.

US Pat. No. 10,136,925

SPINAL CROSS-CONNECTOR

NuVasive, Inc., San Dieg...

1. A spinal cross-connector for connecting first and second spinal rods, comprising:an L-shaped elongate member having a long portion with a first end and a short portion with a second end;
a first connector configured to directly attach with a first pedicle screw, said first connector includes a first collet head configured to receive a first tulip head of the first pedicle screw and accommodate a first spinal rod residing within the first tulip head, a first clamp configured to slidably receive the first end of the L-shaped elongate member, a first locking member tightenable over the first collet head that both locks the first end of the L-shaped elongate member with respect to the first clamp, and locks the first connector to the first tulip head; and
a second connector configured to directly attach with a second pedicle screw, said second connector includes a second collet head configured to receive a second tulip head of the second pedicle screw and a plurality of cutouts to accommodate a second spinal rod residing within the second tulip head, a second clamp configured to rotatably receive the second end of the L-shaped elongate member, a second locking member tightenable over the second collet head that both locks the second end of the L-shaped elongate member with respect to the second clamp, and locks the second connector to the second tulip head.

US Pat. No. 10,136,924

POLYAXIAL BONE SCREW

DePuy Synthes Products, I...

1. A polyaxial bone anchor assembly, comprising:a shank having a spherical head formed on a proximal end thereof;
a receiver member adapted to receive a spinal rod and having a distal opening though which the shank extends and a distal seat in which the head of the shank is polyaxially seated; and
a compression cap that is spring biased in a distal direction relative to the receiver member such that the compression cap exerts distal pressure on the spherical head of the shank to frictionally engage the spherical head of the shank.

US Pat. No. 10,136,923

POLYAXIAL BONE FIXATION ELEMENT

DePuy Synthes Products, I...

1. An assembly configured to couple a spinal rod to a vertebra, the assembly comprising:a body that is elongate along a first longitudinal axis, the body including an upper end that defines an upper opening, a lower end that defines a lower opening, a bore that extends between the upper opening and the lower opening along the longitudinal axis, the bore defining a rod-receiving channel configured to receive the spinal rod, the rod-receiving channel disposed along a channel axis that is oriented substantially perpendicular to the longitudinal axis, the bore at least partially defined by a first curved surface that forms a first spherical undercut having a first body diameter, and the bore at least partially defined by a second curved surface that forms a second spherical undercut having a second body diameter that is larger than the first body diameter, the first curved surface positioned closer to the lower opening with respect to a direction parallel to the longitudinal axis than the second curved surface is to the lower opening with respect to the direction, the body further including a collet retention feature positioned at a fixed location between the upper opening and the second curved surface such that the collet retention feature is configured to inhibit movement of a collet that is between the collet retention feature and the lower opening from passing through the upper opening, the collet retention feature defining a retention opening having a third body diameter, and the lower opening defining a fourth body diameter; and
a bone anchor that is elongate along a second longitudinal axis, the bone anchor including a head portion, a shaft portion, and a neck portion positioned between the head portion and the shaft portion, the head portion defining a first screw diameter measured perpendicular to the second longitudinal axis, the shaft portion defining a second screw diameter measured perpendicular to the second longitudinal axis, and the neck portion defining a third screw diameter perpendicular to the second longitudinal axis,
wherein the third screw diameter is less than both the first screw diameter and the second screw diameter, the first screw diameter is less than both the first body diameter and the second body diameter, and the third body diameter is greater than the fourth body diameter and less than the second body diameter.

US Pat. No. 10,136,922

BONE ANCHORING DEVICE AND TOOL COOPERATING WITH SUCH A BONE ANCHORING DEVICE

1. A bone anchoring device comprising:a bone anchoring element;
a receiving part for coupling a rod to the bone anchoring element, the receiving part comprising:
a rod receiving portion with a first end, a second end, and a U-shaped recess for receiving the rod, the recess extending from the first end in a direction of the second end and defining two free legs; and
a second portion at the second end of the rod receiving portion that is connectable to the bone anchoring element, wherein when the bone anchoring element is connected to the second portion of the receiving part, the bone anchoring element and the receiving part are pivotable relative to one another; and
a locking ring configured to be arranged around the second portion of the receiving part, the locking ring comprising a first end, a second end, and an outer surface extending between the first and second ends;
wherein when the bone anchoring element is connected to the second portion of the receiving part and the locking ring is around the second portion, the locking ring can assume a locking position where a compressive force is exerted on the bone anchoring element to lock an angular position of the bone anchoring element relative to the receiving part; and
wherein an engagement structure comprising a projection or a groove is provided on the outer surface of the locking ring, and wherein a portion of the engagement structure forms an abutting surface positioned away from end faces at the first and second ends of the locking ring that is configured to be pushed by a tool to move the locking ring away from the first end of the rod receiving portion towards the locking position, the abutting surface having at least a section that extends axially when viewed in a circumferential direction around the locking ring.

US Pat. No. 10,136,921

ELONGATED PIN FOR APPLICATION OF AN EXTERNAL FIXATOR

Orthofix S.R.L., Verona ...

1. An elongated pin foran external fixator for temporary and/or permanent fixation applications to treat bone fractures and to connect two or more bone fragments to each other, comprising:
an elongated cylindrical stem extending along a longitudinal axis (X),
the elongated cylindrical stem further comprising:
a cylindrical end area comprising an external thread; and
a thread-free area extending along most of the length of the elongated cylindrical stem; and
a conical end portion extending adjacent to the cylindrical end area of the elongated cylindrical stem, the conical end portion comprising a tip and an external thread for inserting the elongated pin into a bone,
wherein the conical end portion comprising the tip has an overall length, measured along the longitudinal axis (X), equal to the diameter (d) of the elongated cylindrical stem ±20% of the diameter (d), and
wherein the threaded cylindrical end area of the elongated cylindrical stem has a length, measured along the longitudinal axis (X), equal to the diameter (d) of the elongated cylindrical stem ±25% of the diameter (d).

US Pat. No. 10,136,920

ADJUSTABLE CALCANEAL RESTRAINT SYSTEM

1. A treatment method for treating injuries to a patient's calcaneus performing a first surgical procedure wherein a calcaneal pin aperture is created laterally through a patient's calcaneus;inserting a calcaneal pin transversely through the patient's calcaneus;
providing an adjustable calcaneal restraint apparatus, the adjustable calcaneal restraint apparatus comprising:
a rigid framework with a first end configured to be affixed to a lower leg of the patient, and a second end configured for support transverse to the patient's heel;
an adjustment member operably connected to a first end and a second end of the calcaneal pin by a cable, the adjustment member being movably mounted to the second end of the rigid framework such that it can be set in transverse positions across the second end of the rigid framework; and
wherein movement of the adjustment member relative to the second end of the rigid framework changes the calcaneus pin angle;
securing the adjustable calcaneal restraint apparatus to the patient;
adjusting the adjustable calcaneal restraint apparatus to manipulate the patient's calcaneus or pieces of the patient's calcaneus;
imparting a biasing force on the cable between the adjustment member and the calcaneal pin;
waiting an amount of time for the patient's calcaneal and surrounding tissue to be in a desirable condition to perform a second surgical procedure; and
performing the second surgical procedure on the patient's calcaneus to fix the calcaneus or pieces of the calcaneus in a desired location while the adjustable calcaneal restraint apparatus is fixed to the patient.

US Pat. No. 10,136,919

EXTERNAL FIXATOR ASSEMBLY

GLOBUS MEDICAL, INC., Au...

1. An external fixator assembly comprising:a first clamp assembly, wherein the first clamp assembly comprises a first upper member and a first lower member operably connected to one another, wherein the first upper member and the first lower member form a first slot in opposition to a second slot;
a second clamp assembly, wherein the second clamp assembly comprises a second upper member and a second lower member operably connected to one another, wherein the second upper member and the second lower member form a third slot in opposition to a fourth slot forming a pin or rod free zone having a first flat surface and a second flat surface that form a V-opening relative to one another such that a pin or rod would not be retained therein;
a rod received within the first slot or second slot of the first clamp assembly;
a pin received within the third slot of the second clamp assembly, wherein the pin is sized and configured to extend into a tibial bone.

US Pat. No. 10,136,918

LAPAROSCOPIC PORT

EON SURGICAL LTD., Tel-A...

1. A laparoscopic port, comprising:a tubular member comprising a proximal end and a distal end and a lumen extending therebetween;
at least one seal member provided in said lumen, the at least one seal member including a duckbill or zero seal to prevent pressurized gas flow from said distal end to said proximal end of said tubular member; and
a shielding trigger positioned distal to said seal member in said lumen, said shielding trigger being shaped so as at least a proximal portion of said shielding trigger has a narrowing cross-section that extends towards said seal member, said proximal portion is adapted to actuate a reversible opening and protection of said seal member upon a proximally projected pressure from a distal end of an artifact,
wherein the seal member comprises a distal divergent surface adapted to accommodate a proximally incoming artifact, a proximal convergent surface adapted to accommodate a distally withdrawing artifact, and a normally sealed passage provided therebetween.

US Pat. No. 10,136,917

INTRAVASCULAR CATHETER INSERTION DEVICE

1. A catheter insertion device, comprising:a hollow needle having a distal skin-piercing end opposite a proximal base end, the hollow needle defining a channel in fluidic or pneumatic communication between the distal skin-piercing end and the proximal base end, the hollow needle extending along a longitudinal axis;
a plunger slidably disposed over at least a portion of the hollow needle, where the distal skin-piercing end of the hollow needle extends through a distal end of the plunger;
a spring mechanically engaged between at least a portion of the proximal base end of the hollow needle and a portion of the plunger, the spring biasing the plunger towards the distal skin-piercing end of the hollow needle;
a catheter slidably disposed over at least a second portion of the hollow needle where the distal skin-piercing end of the hollow needle extends through a distal insertion end of the catheter, the catheter comprising the distal insertion end opposite a proximal connection end, where a surface of the catheter contacts the distal end of the plunger during catheter insertion;
an expandable chamber having a first opening in fluidic or pneumatic communication with the channel of the hollow needle, the expandable chamber at least partially formed by the proximal base end of the hollow needle and a proximal end of the plunger, the expandable chamber configured to increase in volume as the plunger moves towards the distal skin-piercing end of the hollow needle;
a housing attached to the proximal base end of the hollow needle, the housing having an open distal end opposite the proximal base end of the hollow needle;
a first circumferential seal of the expandable chamber disposed about the proximal base end of the hollow needle, the first circumferential seal configured to seal the proximal base end to the plunger when the plunger is moved to its furthest proximal position;
a second circumferential seal of the expandable chamber disposed about the plunger, the second circumferential seal configured to seal the plunger to the housing when the plunger is moved to its furthest proximal position;
a button non-movably attached to the plunger and extending outside of the housing;
wherein the housing includes a slot, wherein the slot extends from a slot open end to a slot closed end with a slot turn there between, wherein the slot open end is located at the open distal end of the housing, wherein at least a portion of the slot extending from the slot open end to the slot turn is non-linear with respect to the longitudinal axis of the hollow needle, the slot turn changing direction of the slot between the slot open end and the slot closed end;
wherein the plunger moves with the button and a portion of the button is configured to be movable within the slot between a stored position, an armed position and an extended position, wherein the stored position comprises when the portion of the button is located at the slot closed end, wherein the armed position comprises when the portion of the button is located at the slot turn, and wherein the extended position comprises when the portion of the button is located at and/or past the slot open end;
wherein the plunger is configured to rotate about the longitudinal axis of the needle as the portion of the button passes through the non-linear portion of the slot.

US Pat. No. 10,136,916

ACCESS DEVICE

Access Scientific, LLC, ...

1. An access device for placing a medical article within a body space, comprising:a needle having an elongated needle body with a distal end and a needle hub from which the needle body extends;
a dilator slideably disposed on the needle body and comprising a dilator hub and an elongated dilator shaft that extends from the dilator hub to a distal end, the dilator hub comprising a receiving portion; and
an insert disposed within the dilator hub and supported by the receiving portion, the insert comprising a through-hole configured to receive the needle body therethrough such that the needle body is capable of extending through the insert, at least a portion of the through-hole being sized and shaped relative to the needle body so as to form a space between the insert and the needle body that allows gases to pass through the space and to the atmosphere but hinders the passage of a body fluid through the space.

US Pat. No. 10,136,915

ULTRASOUND NEEDLE GUIDE APPARATUS

LOVING HEART MEDICAL TECH...

1. An ultrasound needle guide apparatus to aid guidance of a puncturing needle to locate blood vessel positions of a living body and perform puncturing operation, comprising:an ultrasound detection device including a probe head which is configured to contact with the living body to detect the blood vessel positions via ultrasonic waves, a grip shell connected to the probe head, a first hinge portion located on the grip shell, and an image process unit located in the grip shell and electrically connected to the probe head;
a display element which is rotatably connected to the grip shell and includes a second hinge portion hinged on the first hinge portion and a display screen electrically connected to the image process unit through the first hinge portion and the second hinge portion to get ultrasonic signals from the probe head and display the blood vessel positions of the living body; and
a needle positioning aid element fastened to the ultrasound detection device and located beside the probe head, including a body fixed on the ultrasound detection device and a positioning aid support portion located at one side of the body remote from the ultrasound detection device to aid positioning of the puncturing needle;
wherein the body includes a curved section and two clamp sections at two ends of the curved section, the two clamp sections is corresponding with the curved section to clamp the grip shell from two sides of the grip shell, the grip shell includes two guide trough respectively corresponding to the two clamp sections that has an axis perpendicular to the probe head.

US Pat. No. 10,136,914

ANCHORING DEVICE FOR ANCHORING A BORING TOOL IN A LUMEN OR VESSEL

1. An anchoring system for anchoring a boring tool at a site in a lumen or vessel, the anchoring system comprising:an anchoring device for anchoring the boring tool at the site in the lumen or vessel, and
a delivery device for delivering the anchoring device to the site in the lumen or vessel, the delivery device comprising:
an expandable member mounted thereon,
the anchoring device comprising:
an expandable element adapted for expanding in the lumen or vessel to anchor the anchoring device therein, the expandable element being releasably mountable on and engageable with the expandable member of the delivery device for delivering the anchoring device to the site in the lumen or vessel, the expandable element defining a main central axis and being expandable with the expandable member of the delivery device for anchoring the anchoring device adjacent the site in the lumen or vessel,
a securing means located on the expandable element engageable with the expandable member for securing the expandable element to the expandable member and for retaining the expandable element secured to the expandable member during expanding of the expandable element by the expandable member, a guide element defining a guide bore extending therethrough to accommodate one of a boring tool and a carrier element of the boring tool for guiding the boring tool, the guide bore defining a secondary central axis extending at an angle greater than 0° to the main central axis defined by the expandable element, and
an engagement means located in the guide element and engageable with one of the boring tool and the carrier element of the boring tool so that the boring tool is urgeable outwardly of the guide element against the anchoring device.

US Pat. No. 10,136,913

MULTIPLE CONFIGURATION SURGICAL CUTTING DEVICE

The Spectranetics Corpora...

1. A device for removing an implanted object from a body vessel, the device comprising:an intermediate sheath assembly comprising an intermediate sheath and an intermediate tip disposed at a distal end of the intermediate sheath assembly;
an inner sheath assembly rotatably carried within the intermediate sheath assembly, the inner sheath assembly comprising an inner sheath and a cutting tip, the cutting tip comprising a cutting surface adapted to cut tissue coupled to the implanted object as the cutting tip rotates relative to the intermediate sheath assembly;
a handle assembly comprising a housing, a trigger carried by the housing, and a cutting tip drive mechanism carried by the housing and coupled to the trigger and the inner sheath assembly, the trigger being actuatable to drive the cutting tip drive mechanism and thereby rotate the inner sheath and the cutting tip relative to the intermediate sheath assembly;
an outer sheath assembly rotatably carried outside of the intermediate sheath assembly, the outer sheath assembly comprising an outer sheath and an outer shield disposed at a distal end of the outer sheath assembly, the outer shield comprising a distal opening, the outer sheath assembly being rotatable and translatable relative to the intermediate sheath assembly from a first position to a second position and vice versa, in the first position the cutting surface of the cutting tip being disposed within the outer shield, and in the second position the cutting tip extending through the distal opening and the cutting surface being at least partially disposed outside of the outer shield; and
a shield drive mechanism coupled to the outer sheath assembly, the shield drive mechanism being actuatable to rotate and translate the outer sheath assembly relative to the intermediate sheath assembly from the first position to the second position and vice versa.

US Pat. No. 10,136,912

METHOD, APPARATUS, AND SYSTEM FOR GENERATING ULTRASOUND

Samsung Electronics Co., ...

1. A method to generate a therapeutic ultrasound wave from a therapeutic ultrasound irradiation device, the method comprising:acquiring a medical image comprising anatomical information about a subject using a processor;
calculating one or more characteristics of a heterogeneous tissue in the subject affecting propagation of the therapeutic ultrasound wave based on the medical image using the processor;
determining a parameter of the therapeutic ultrasound wave, using the processor, to create a focal point on the subject using the one or more calculated characteristics; and
generating the therapeutic ultrasound wave at the therapeutic ultrasound irradiation device, using a signal from the processor, the signal determined according to the determined parameter,
wherein the determining of the parameter comprises:
setting a particle velocity of the therapeutic ultrasound wave;
calculating, using the processor, a sound pressure at the focal point that the therapeutic ultrasound wave propagates through the heterogeneous tissue, based on the one or more calculated characteristics of the heterogeneous tissue;
determining, using the processor, whether the sound pressure satisfies a predetermined pressure condition; and
resetting, using the processor, the particle velocity of the therapeutic ultrasound wave, in response to the sound pressure not satisfying the predetermined pressure condition.

US Pat. No. 10,136,911

ANTI-CLOGGING DEVICE FOR A VACUUM-ASSISTED, TISSUE REMOVAL SYSTEM

DePuy Synthes Products, I...

1. A surgical, nucleus pulposus removal system having an anti-clogging device for a vacuum-assisted tissue removal, the system comprising:an anti-clogging device including a tubular cutting head, a suction assembly, a collection handle, the collection handle configured for a manual control of the tubular cutting head in an operable communication with the suction assembly, and a tissue-separation chamber to avoid a clogging of a tissue removal system for a discectomy; wherein,
the tissue separation chamber has
an entry port for the entry of an extracted tissue into the chamber, the extracted tissue having a solid component and a liquid component, the solid component including a nucleus pulposus tissue;
a baffle to separate the solid component from the liquid component; and,
an exit port for the exit of the liquid component from the chamber;
the tubular cutting head is configured for removing a target tissue of a subject, the cutting head having
an outer perimeter that circumscribes a flow of suction through the cutting head;
a lumen circumscribed by the outer perimeter, the lumen guiding the flow of suction and having a central axis;
a forward cutting blade on a distal edge of the outer perimeter, the forward cutting blade configured for (i) cutting the nucleus pulposus tissue in a forward stroke of the cutting head and (ii) excising and directing entry of the excised nucleus pulposus tissue into the lumen on the forward stroke, the forward cutting blade having a first plane and a second plane, the first plane having a plurality of cutting surfaces and positioned at an angle, ?FP, to the central axis of the lumen of the tubular cutting head; and, the second plane having a plurality of cutting surfaces and positioned at an angle, ?SP, to the central axis of the lumen of the tubular cutting head; and,
a blade guard positioned distal to the forward cutting blade and configured to guard an annulus fibrosis tissue from the forward cutting blade upon the forward stroke, the blade guard having a transverse, cross-sectional width that is at least substantially smaller than the width of a transverse cross-section of the lumen to facilitate the entry of the excised nucleus pulposus tissue into the lumen on the forward stroke, such that the desired entry of the excised nucleus pulposus tissue into the lumen on the forward stroke is reduced by less than 50% due to the presence of the blade guard, the blade guard also being a backward cutting blade configured with a barb to hook nucleus pulposus tissue for removal of the nucleus pulposus tissue in a backward stroke of the cutting head, the guard having a double-edged blade tip pointing back into the lumen at an angle, ?2, of greater than 90° to trap tissue, cut tissue, or trap and cut tissue in the lumen in the backwards stroke of the cutting head;
wherein, the cutting head is configured for an operable communication between the lumen and a source of a suction; and,
the suction assembly is configured for an operable communication with the cutting head, the suction assembly comprising an at least substantially rigid suction tube with a central axis and creating the flow of suction for removing the excised nucleus pulposus tissue through the lumen and out of the subject.

US Pat. No. 10,136,910

SURGICAL DEVICE WITH ANTI-BINDING FEATURES

Ethicon LLC, Guaynabo, P...

1. A surgical device, comprising:a handle having an elongate shaft extending distally therefrom;
an end effector at a distal end of the elongate shaft and having first and second jaws that are movable between an open configuration and a closed configuration in which the first and second jaws are configured to engage tissue therebetween;
a closure tube extending through the handle and the elongate shaft and configured to move the first and second jaws between the open configuration and the closed configuration;
a knife pusher shaft disposed at least partially around the closure tube and configured to move a cutting element through the first and second jaws for cutting tissue engaged therebetween; and
a rack coupled to the knife pusher shaft by a ball-and-socket joint such that the knife pusher shaft can pivot relative to the rack, wherein movement of the rack is effective to drive the knife pusher shaft and thereby move the cutting element through the first and second jaws.

US Pat. No. 10,136,909

MAGNETIC INTRODUCER SYSTEMS AND METHODS

AtriCure, Inc., Mason, O...

1. A system for creating a lesion in an epicardial tissue of a patient with ablative energy, comprising:a first introducer having a distal portion comprising a pre-formed bend and a proximal portion each extending along a longitudinal axis of the first introducer where the distal portion further comprises a first flat distal surface, and where the distal portion comprises a first coupling member;
a second introducer having a distal portion and a proximal portion each extending along a longitudinal axis of the second introducer, where the distal portion further comprises a second flat distal surface, and where the distal portion comprises a second coupling member; and
a treatment device having an ablation assembly that includes an ablation member configured to deliver an ablation energy that creates the lesion in the epicardial tissue of the patient,
wherein the treatment device is configured to be releasably coupled with the proximal portion of the first introducer,
wherein the first coupling member of the first introducer comprises a magnet adjacent to the first flat distal surface, and the second coupling member of the second introducer comprises a magnet in the second flat distal surface, wherein the magnet of the first introducer has a magnetic dipole and the magnet of the second introducer has a magnetic dipole, and wherein attraction between the first introducer magnet and the second introducer magnet operates to align the first introducer magnet dipole with the second introducer magnet dipole such that when positioned adjacently the first flat distal surface engages the second flat distal surface,
wherein the first and second introducers are configured to translate along their respective longitudinal axes while the respective coupling members are joined, and
wherein coupling between the proximal portion of the first introducer and the treatment device, in combination with coupling between the first and second introducers provided by their respective magnets, is effective to move the treatment device toward a treatment location on the epicardial tissue when the second introducer is moved away from the treatment location on the epicardial tissue.

US Pat. No. 10,136,908

COAXIAL COIL LOCK

COVIDIEN LP, Mansfield, ...

1. A surgical instrument, comprising:a housing;
an elongated shaft extending distally from the housing and defining a longitudinal axis, the elongated shaft including a flexible portion configured to movably support an end effector such that, bending of the flexible portion is configured to induce pivotal movement of the end effector with respect to the longitudinal axis; and
a locking mechanism coaxially disposed about the flexible portion and selectively rotatable relative to the flexible portion about the longitudinal axis, wherein upon rotation of the locking mechanism about the longitudinal axis in a first direction, the locking mechanism is configured to laterally engage the flexible portion to impede bending of the flexible portion and pivotal movement of the end effector, and wherein upon rotation of the locking mechanism about the longitudinal axis in a second direction, the locking mechanism is configured to laterally disengage from the flexible portion enabling flexure of the flexible portion and pivotal movement of the end effector.

US Pat. No. 10,136,907

METHODS OF LOCATING AND TREATING TISSUE IN A WALL DEFINING A BODILY PASSAGE

COOK MEDICAL TECHNOLOGIES...

1. A delivery device, comprising:a housing having a housing proximal end, a housing distal end, and a housing body defining a housing lumen;
a cannula having a cannula proximal end, a cannula distal end, and a cannula body defining a cannula lumen, the cannula attached to the housing such that the housing lumen and the cannula lumen are in communication;
a pusher having a pusher proximal end, a pusher distal end slidably disposed within the housing lumen, and a pusher body that defines a pusher lumen, the pusher moveable between a pusher first configuration and a pusher second configuration; and
a catheter attached to the pusher and having at least a portion disposed within the cannula lumen, the catheter comprising an elongate member and a balloon, the elongate member having an elongate member proximal end, an elongate member distal end, and an elongate member body defining an inflation lumen in communication with the pusher lumen and an elongate member curve, the balloon disposed on the elongate member and having a wall defining a balloon chamber in communication with the inflation lumen, the balloon moveable between a first deflated configuration and a second inflated configuration as fluid is moved into and out of the balloon chamber, the elongate member adapted to move between a first substantially straight configuration in which the portion of the elongate member that defines the elongate member curve is substantially straight when disposed within the cannula lumen and a second curved configuration when the portion of the elongate member that defines the elongate member curve is free of the cannula lumen.

US Pat. No. 10,136,906

CATHETER WITH OCCLUDING CUFF

Covidien LP, Mansfield, ...

1. A catheter for use in a medical procedure, the catheter comprising:an elongate member defining a longitudinal axis; and
a sealing member supported by the elongate member, the sealing member including a frame comprising an interior side facing towards the elongate member and an exterior side facing away from the elongate member, and a membrane positioned on the interior side of the frame, wherein the membrane is fixed to the elongate member and extends continuously around an outer perimeter of the elongate member in a direction transverse to the longitudinal axis, the sealing member being repositionable, while the membrane is fixed to the elongate member, between a first position, wherein a portion of the membrane is separated from the interior side of the frame to permit fluid flow through the sealing member, and a second position, wherein the membrane sealingly engages the interior side of the frame to prevent fluid flow through the sealing member.

US Pat. No. 10,136,905

BALLOON CATHETER

ASAHI INTECC CO., LTD., ...

1. A balloon catheter comprising:a balloon;
an outer shaft;
an inner shaft joined to a distal end of the balloon and comprising a coil body; and
a tip having:
a step portion provided on an inner surface thereof and configured to come in contact with a distal end of the inner shaft; and
a proximal end portion that covers an outer periphery of the distal end of the balloon,
wherein:
the distal end of the balloon is sandwiched between the inner shaft and the proximal end portion of the tip,
an outer periphery of the inner shaft has an uneven surface topography, corresponding to the shape of the coil body, at a joining portion in which the distal end of the balloon, the inner shaft, and the tip are joined, and
an inner periphery of the distal end of the balloon at the joining portion has an uneven surface topography corresponding to the uneven surface topography of the outer periphery of the inner shaft.

US Pat. No. 10,136,904

ANKLE REPLACEMENT SYSTEM AND METHOD

Wright Medical Technology...

1. A surgical device, comprising:a body including a handle disposed at a first end and a locking protrusion extending in a direction away from a longitudinal direction of the body, the locking protrusion defining an opening and defining a hole that extends parallel to the longitudinal direction of the body;
a locking tab slidably received within the opening defined by the locking protrusion, the locking tab defining an aperture having first and second portions, the first portion being narrower than the second portion, the locking tab being sized and configured to be received within the opening defined by the locking protrusion of the body;
a pair of spaced apart rails configured to be disposed along a length of the body; and
a plunger rod sized and configured to be received slidably within a threaded hole defined by the handle, the aperture defined by the locking tab, and the hole defined by the locking protrusion, wherein the plunger rod comprises a handle at a proximal end and a shoulder having an enlarged diameter along a length of the plunger rod with a threaded portion adjacent to the shoulder, the threaded portion configured to engage the threaded hole defined by the handle, the plunger rod further comprising a reduced diameter region adjacent to a distal end of the plunger rod, the reduced diameter region having a diameter that is sized and configured to be received within the first portion of the aperture defined by the locking tab for locking the plunger rod in a retracted position,
wherein the surgical device is configured to be coupled releasably to a first implant component and to guide a second implant component into position with respect to the first implant component.

US Pat. No. 10,136,903

TOURNIQUET AND METHOD THEREOF HAVING COMPLIANCE LOGGING AND ALERT FEATURES, AND A SYSTEM THEREOF

Patrick James Lynch, Haw...

1. A tourniquet for blood constriction using a strap and a clasp connected to the strap, which is adjustably configured, and communicable with an external communication apparatus configured to transmit a logging confirmation signal to the tourniquet confirming a successful logging of compliance, the tourniquet comprising:a controller;
an indicator connected to the controller;
a first sensor connected to the controller; and
a housing containing the controller and the first sensor,
wherein the housing includes a receptacle configured to receive the clasp,
wherein the first sensor is configured to output a first signal when the clasp is inserted into the receptacle, and
wherein the controller comprises:
a first communication interface configured to communicate with the external communication apparatus;
a memory; and
a processor configured to execute:
a first determining task that determines whether the clasp has been inserted in the receptacle based on whether the first signal is received;
a first communication task that controls the first communication interface to initiate communication with the external communication apparatus upon the first determining task determining that the clasp has been inserted; and
an alerting task that controls the indicator to alert a user confirming whether the compliance has been satisfied.

US Pat. No. 10,136,902

SURGICAL INSTRUMENT AND METHOD

Warsaw Orthopedic, Inc., ...

1. A surgical instrument comprising:a proximal end including a tool engagement surface; and
a distal end configured to form a threaded bore in vertebral tissue to receive an implant that is separate from the surgical instrument, the distal end including a first thread, a second thread spaced from the first thread and at least one tissue depth indicia, the first thread having a maximum length that is greater than a maximum length of the second thread, the distal end comprising a tapered tip, the second thread being positioned between the first thread and the tip, the first thread having a major diameter that is equal to a major diameter of the second thread, the first thread including a first lead and the second thread including a second lead, the leads being different.

US Pat. No. 10,136,901

ANATOMICAL CONCENTRIC SPHERES THA

Depuy Ireland Unlimited C...

1. A cutting guide for use with total hip arthroplasty, the cutting guide comprising:a semispherical cutting guide for coupling to a proximal femur, the cutting guide including a concave cutting guide surface section that mimics the arc of a natural femoral ball of a hip joint and is configured to guide a cutting tool to remove the natural femoral ball and form a concave resected surface on the proximal femur, the cutting guide including a retainer configured to be secured to the proximal femur below the natural femoral ball of the hip joint.

US Pat. No. 10,136,899

CLAMP FOR USE WITH A CUTTING DEVICE

PRICE INVENA APS, Copenh...

1. A clamp comprising:a first leg having an inner face comprising a clamping bed,
a second leg attached at one end to the first leg at one end of said clamping bed by a resilient hinge by which the legs are sprung apart, said second leg having an inner face comprising a clamping bed extending part of the length of the inner face of said second leg from the hinge attached end of said second leg, and a recessed section extending from the clamping bed of said second leg to an opposite end of said second leg;
a third leg attached to said first leg at an opposite end of said clamping bed of the first leg by a resilient hinge by which the third and first legs are sprung apart, said third leg comprising a clamping bed extending the length of an inner face of said third leg, and a contact section on an outer face of said third leg;
wherein said first leg, said second leg and said third leg together form a cavity capable of receiving an object to be clamped,
wherein pressing said second leg towards the first leg against the resilience of the hinge joining them causes said recessed section of the second leg to contact said contact section on said third leg such that said third leg is pressed towards the first leg against the resilience of the hinge joining them,
wherein said recessed section is recessed such that said third leg fits into said recessed section when said clamp is closed,
wherein the clamping beds of said second and third legs together form a contiguous clamping bed for clamping a received object against the clamping bed of the first leg when said clamp is closed, and
wherein said first leg is parallel to said second and third legs when said clamp is closed.

US Pat. No. 10,136,898

NARROW PROFILE SURGICAL LIGATION CLIP

TELEFLEX MEDICAL INCORPOR...

1. A surgical ligation clip, defining a longitudinal axis and comprising:first and second legs each extending along the longitudinal axis and having proximal and distal end portions with respect to said longitudinal axis,
a clip hinge joining the first and second legs at a point on their respective proximal end portions, the first and second legs each having inner clamping surfaces between the clip hinge and the distal end portions of said first and second legs, the clamping surfaces being substantially apposed when the clip is in a fully closed position,
a first jaw structure on the first leg extending proximal to the clip hinge, the first jaw structure having a first curved inner surface extending proximally from the clip hinge and facing the longitudinal axis and being substantially concave viewed from said axis,
a second jaw structure on the second leg extending proximal to the clip hinge, the second jaw structure having a second curved inner surface extending proximally from the clip hinge and facing the longitudinal axis and being substantially concave viewed from said axis, and
a buttress body extending from and connected to both the first jaw structure and the second jaw structure by a first living hinge and second living hinge, respectively extending from said first jaw structure and second jaw structure, the buttress body having an outer surface,
the first and second jaw structures being spaced from the longitudinal axis on opposite sides thereof and defining a locking space therebetween, the buttress body being moveable into the locking space such that at least first and second curved planar segment abutment portions of the outer surface of the buttress body each abuts against the substantially concave curved inner surfaces of the first and second jaw structures to bias the clip in a closed position,
wherein the buttress body forms a substantially cylindrical or generalized cylindrical body spanning laterally on a proximal end of the clip, and the locking space is a socket space and a volume subtended by the buttress body can occupy substantially all of said socket space, and
wherein when said buttress body is disposed in said locking space, abutment of the buttress body against the respective substantially concave curved inner surface of each of the first jaw structure and second jaw structure creates moments acting about the clip hinge directly on the first and second jaw structures, which moments directly act on the first and second legs to urge said legs closed and supply a clamping force between said legs.

US Pat. No. 10,136,897

EXPANDABLE VASO-OCCLUSIVE DEVICES HAVING SHAPE MEMORY AND METHODS OF USING THE SAME

Boston Scientific Scimed,...

1. A vaso-occlusive device comprising an elongated device portion and one or more expandable components which comprise a shape memory material and which expand laterally outward from the elongated device portion upon being subjected to an increase in temperature from below a thermal transition temperature of the shape memory material to above the thermal transition temperature of the shape memory material.

US Pat. No. 10,136,895

USE OF REMOTE ISCHEMIC CONDITIONING TO IMPROVE OUTCOME AFTER MYOCARDIAL INFARCTION

The Hospital for Sick Chi...

1. A method for reducing the incidence, delaying the onset, and/or reducing the severity of heart dysfunction and/or failure following a myocardial infarction comprising:performing repeated remote ischemic conditioning (RIC) regimens on a subject beginning after an ischemic phase and a reperfusion phase of the myocardial infarction and continuing for at least three days.

US Pat. No. 10,136,894

NERVE TREATMENT METHODS

BOARD OF REGENTS, THE UNI...

1. A method of coaptation of a first and second nerve segments having cut but not crushed ends, said segments being segments of a nerve that has been cut but not crushed comprising the steps of:a) applying a hypotonic, calcium-free saline solution to said first and second cut but not crushed nerve segments of a nerve that has been cut but not crushed, for a first period of time;
b) concurrent with or after step a), applying to said nerve segments a solution containing an antioxidant inhibitor of membrane sealing for a second period of time;
c) bringing into contact a cut end of the first nerve segment with a cut end of the second nerve segments;
d) then applying a lipid membrane fusogen solution to said contacted first and second nerve segments for a third period of time; and
(e) applying to the contacted nerve segments an isotonic, calcium-containing solution for a fourth period of time, to thereby coapt said contacted nerve first and second nerve segments.

US Pat. No. 10,136,893

ENDOVASCULAR ANASTOMOTIC CONNECTOR DEVICE, DELIVERY SYSTEM, AND METHODS OF DELIVERY AND USE

CircuLite, Inc., Teaneck...

1. A delivery system comprising:an anastomotic connector including:
a vascular conduit having a proximal end, a distal end, and a lumen extending therebetween, wherein the vascular conduit is configured to reside within a vascular structure; and
a supply conduit having a proximal end, a distal end, and a lumen extending therebetween, wherein the distal end of the supply conduit forms a bifurcation joint with the vascular conduit and the proximal end of the supply conduit is configured to extend from the vascular structure and couple to an auxiliary device; and
a delivery subassembly, the delivery subassembly having an assembled position including:
a multi-lumen hub having a first lumen and second lumen;
a multi-lumen delivery shaft including a first lumen and a second lumen, the multi-lumen delivery shaft extending through the first lumen of the multi-lumen hub then through the lumen of the supply conduit, through the lumen of the distal end of the vascular conduit, and distally from the distal end of the vascular conduit; and
a secondary delivery shaft extending through the second lumen of the multi-lumen hub then into the proximal end of the vascular conduit, through the lumen of the vascular conduit, and distally from the distal end of the vascular conduit, wherein a distal portion of the secondary delivery shaft extending distally from the distal end of the vasculature conduit and is received by a distal portion of the first lumen of the multi-lumen delivery shaft extending distally from the distal end of the vascular conduit.

US Pat. No. 10,136,892

APPARATUS AND METHOD FOR RESECTIONING GASTRO-ESOPHAGEAL TISSUE

REX Medical, L.P., Radno...

1. An apparatus, comprising:a head having a first jaw and a second jaw, at least one of the first jaw and the second jaw being movable with respect to the other of the first jaw and the second jaw from a first configuration in which the first jaw and the second jaw are spaced apart at a first distance and a second configuration in which the first jaw and the second jaw are spaced apart at a second distance, a stapling assembly of the first jaw having slots through which staples are configured to be passed in one or more rows extending from a proximal end of the first jaw to a distal end of the first jaw, and an anvil surface of the second jaw being configured to form a staple;
a first adjustment assembly configured for gross movement of the first jaw or the second jaw;
a second adjustment assembly including a beam configured for fine movement of the first jaw or the second jaw to maintain a fixed distance there between, wherein the beam is operatively coupled to a pusher and includes a central web portion connecting an upper beam portion and a lower beam portion, the central web portion including a cutting blade which is generally more distal than at least one of a trailing edge of the upper beam portion and a trailing edge of the lower beam portion, and the pusher being configured to cause a staple pusher to move for firing as the beam moves distally;
a handle having one or more actuators configured to move at least one of the first jaw and the second jaw from the first configuration to the second configuration, and to actuate the stapling assembly; and
a shaft coupling the handle to the head; wherein
at least one of the upper beam portion and the lower beam portion is a generally flat plate orthogonally attached to an end of the central web portion and is configured to engage the first jaw or the second jaw entirely from within the first jaw or the second jaw for clamping and alignment; and
the pusher and the central web portion are coplanar with a channel defined in a tissue contacting surface of each of the first jaw and the second jaw when the beam moves distally.

US Pat. No. 10,136,891

NATURALLY DERIVED BIOABSORBABLE POLYMER GEL ADHESIVE FOR RELEASABLY ATTACHING A STAPLE BUTTRESS TO A SURGICAL STAPLER

Ethicon LLC, Guaynabo, P...

11. A surgical stapler end effector, the end effector comprising:(a) a staple cartridge, wherein the staple cartridge comprises a deck;
(b) an anvil, wherein the anvil is movable from an open position toward the staple cartridge to reach a closed position, wherein the anvil includes an underside;
(c) a buttress assembly, wherein the buttress assembly comprises:
(i) a buttress body, and
(ii) an adhesive material, wherein the adhesive material is configured to removably secure the buttress body to the deck of the staple cartridge or the underside of the anvil; and
(d) a retainer, wherein the retainer is configured to releasably hold the buttress body and wherein the retainer includes an injection port that is configured to receive a syringe needle to thereby permit injection of the adhesive.

US Pat. No. 10,136,890

STAPLE CARTRIDGE COMPRISING A VARIABLE THICKNESS COMPRESSIBLE PORTION

Ethicon LLC, Guaynabo, P...

1. A surgical instrument, comprising:an anvil, comprising a longitudinal row of first forming pockets and a longitudinal row of second forming pockets;
a firing member comprising a first cam and a second cam, wherein said first cam comprises a resilient pad, and wherein said second cam is configured to engage said anvil;
a staple cartridge, wherein said staple cartridge is movable relative to said anvil between a first position and a second position, and wherein said staple cartridge comprises:
a cartridge body, comprising:
a deck, comprising:
a longitudinal slot;
a first deck surface positioned on a first side of said longitudinal slot; and
a second deck surface positioned on a second side of said longitudinal slot;
a bottom portion positioned opposite said deck;
a proximal end;
a distal end;
a longitudinal row of first staple cavities extending between said proximal end and said distal end, wherein said first forming pockets are positioned relative to said first staple cavities when said staple cartridge is in said second position; and
a longitudinal row of second staple cavities extending between said proximal end and said distal end, wherein said second forming pockets are positioned relative to said second staple cavities when said staple cartridge is in said second position, and wherein each said first staple cavity and said second staple cavity comprises an opening in said deck;
a metal support extending under said bottom portion, wherein said metal support comprises a bottom cam surface configured to be engaged by said first cam of said firing member to position said cartridge body relative to said anvil;
a plurality of first staple drivers movable between an unfired position and a fired position, wherein each said first staple driver comprises a first support cradle, and wherein a first distance is defined between each said first support cradle and a said first forming pocket when said first staple drivers are in said unfired position;
a plurality of second staple drivers movable between an unfired position and a fired position, wherein each said second staple driver comprises a second staple support cradle, wherein a second distance is defined between each said second support cradle and a said second forming pocket when said second staple drivers are in said unfired position, and wherein said first distance is different than said second distance;
a plurality of first staples, wherein each said first staple is positioned in a said first staple cavity and supported by a said first support cradle, and wherein said first staples comprise a first unformed height;
a plurality of second staples, wherein each said second staple is positioned in a said second staple cavity and supported by a said second support cradle, wherein said second staples comprise a second unformed height, and wherein said first unformed height is different than said second unformed height;
a first tissue thickness compensator, wherein said first tissue thickness compensator comprises polyglycolic acid, wherein said first tissue thickness compensator extends across said longitudinal slot between said first deck surface and said second deck surface, wherein said first tissue thickness compensator comprises a first portion on a first side of said longitudinal slot and a second portion on said first side of said longitudinal slot, wherein said first portion is positioned closer to said longitudinal slot than said second portion, wherein said first portion is aligned with said first staple cavities and is configured to be captured within said first staples along with tissue having a variable thickness, wherein said second portion is aligned with said second staple cavities and is configured to be captured within said second staples along with tissue having a variable thickness, and wherein said first portion is configured to assume different compressed thickness in response to the varying thickness of the tissue;
a first proximal anchor; and
a first distal anchor, wherein said first proximal anchor and said first distal anchor are configured to releasably hold said first tissue thickness compensator to said cartridge body, and wherein said first proximal anchor and said first distal anchor are configured to be incised to release said first tissue thickness compensator from said cartridge body;
a second tissue thickness compensator, wherein said second tissue thickness compensator comprises polyglycolic acid, wherein said second tissue thickness compensator is configured to be captured within said first staples and said second staples along with the tissue having a variable thickness, and wherein said second tissue thickness compensator is configured to assume different compressed thickness in response to the varying thickness of the tissue;
a second proximal anchor;
a second distal anchor, wherein said second proximal anchor and said second distal anchor are configured to releasably hold said second tissue thickness compensator to said anvil, and wherein said second proximal anchor and said second distal anchor are configured to be incised to release said second tissue thickness compensator from said anvil; and
a joint configured to rotatably connected said staple cartridge to said surgical instrument.

US Pat. No. 10,136,889

SYSTEMS AND METHODS FOR CONTROLLING A SEGMENTED CIRCUIT

Ethicon LLC, Guaynabo, P...

1. A powered surgical instrument, comprising:a housing;
a shaft extending from said housing;
an end effector extending from said shaft, wherein said end effector is configured to perform at least one end effector function;
a power source;
a segmented circuit configured to control said powered surgical instrument, wherein said segmented circuit comprises:
a processor segment; and
a motor segment comprising a motor;
a voltage converter configured to supply a first voltage from said power source to said processor segment and a second voltage from said power source to said motor segment, wherein said first voltage and said second voltage are different;
a current sensor configured to measure current within said motor segment; and
a boost converter configured to increase said first voltage to said processor segment when said current exceeds a predetermined value in said motor segment.

US Pat. No. 10,136,888

CIRCULAR STAPLER AND STAPLE HEAD ASSEMBLY THEREOF

TOUCHSTONE INTERNATIONAL ...

1. A circular stapler, comprising:a staple body comprising an annular staple cartridge, an annular cutter located at a distal end of the circular stapler, the annular staple cartridge comprising a plurality of staple holes at an end face thereof, and a ring arranged at an end face of the annular staple cartridge adjacent to the annular cutter; and
an anvil assembly comprising an annular anvil for mating with the annular staple cartridge, an annular cutting pad set inside the annular anvil for mating with the annular cutter and an anvil shaft moveably connected to the staple body, the annular cutting pad being arranged between the anvil shaft and the annular anvil;
wherein when the staple body and the anvil assembly are closed, a first gap exists between an end face of the annular anvil and the end face of the annular staple cartridge, and a second gap exists between an end face of the annular cutting pad and an end face of the ring, wherein a height of the second gap parallel to an axis of the anvil shaft is different from a height of the first gap parallel to the axis of the anvil shaft.

US Pat. No. 10,136,887

DRIVE SYSTEM DECOUPLING ARRANGEMENT FOR A SURGICAL INSTRUMENT

Ethicon LLC, Guaynabo, P...

1. A surgical end effector, comprising:a drive system, comprising:
a proximal assembly comprising a first translatable element, wherein a first aperture is defined in the first translatable element; and
a distal assembly comprising a second translatable element, wherein the second translatable element is releasably coupled to the first translatable element, and wherein a second aperture is defined in the second translatable element;
a pin removably positioned in the first aperture and the second aperture; and
a housing, wherein the drive system is positioned within the housing, wherein the pin is accessible from outside of the housing, wherein the proximal assembly is configured to receive a drive motion from a motor, and wherein the pin is configured to transfer the drive motion from the proximal assembly to the distal assembly when the pin is positioned in the first aperture and the second aperture.

US Pat. No. 10,136,886

KNOTLESS SOFT TISSUE DEVICES AND TECHNIQUES

Biomet Sports Medicine, L...

1. A tissue fixation system, comprising:a tissue fixation device, comprising:
a self-locking construct including a first loop, a second loop, and a first free end;
a first flexible tail coupled to and extending from the first loop;
a second flexible tail coupled to and extending from the second loop; and
a first flexible anchor coupled to the first flexible tail such that the first flexible tail extends through the first flexible anchor;
wherein the self-locking construct is configured such that pulling the first flexible tail opens the first loop and pulling the second flexible tail opens the second loop; and
an arthroscopic cannula,
wherein an elongated free tail portion of the first flexible tail extends longitudinally through the arthroscopic cannula from a first open end of the arthroscopic cannula to a second open end of the arthroscopic cannula.

US Pat. No. 10,136,885

THREE SUTURE LARGE BORE CLOSURE DEVICE AND METHODS

ST. JUDE MEDICAL PUERTO R...

1. A vascular closure device, comprising:a body portion;
an anchor positioned distal of the body portion and positionable through a vessel puncture and internal to a vessel wall;
at least three sutures having portions thereof positioned distal of the anchor;
three pairs of needles carried by the body portion;
wherein the three pairs of needles are operable to advance through a vessel wall, connect to the portions of the at least three sutures at a position distal to the anchor, and retract to pull the at least three sutures through the vessel wall, at least one of the three pairs of needles not extending through the anchor while the anchor is positioned internal to the vessel wall and while the at least one of the three pairs of needles is connected to the portions of the at least three sutures at a position distal to the anchor.

US Pat. No. 10,136,884

METHOD AND APPARATUS FOR ATTACHING TISSUE TO BONE, INCLUDING THE PROVISION AND USE OF A NOVEL KNOTLESS SUTURE ANCHOR SYSTEM, INCLUDING A RETRACTABLE SHEATH

Pivot Medical, Inc., Sun...

1. Apparatus for securing a first object to a second object, the apparatus comprising:an anchor, the anchor comprising:
an elongated body having a distal end, a proximal end, and a lumen extending between the distal end and the proximal end, the lumen comprising a distal section and a proximal section, the distal section of the lumen having a wider diameter than the proximal section of the lumen;
a window extending through the side wall of the elongated body and communicating with the lumen, the window being disposed in the vicinity of an intersection between the distal section of the lumen and the proximal section of the lumen and being sized to receive a first object therein;
an elongated element extending through the lumen of the elongated body, the elongated element comprising a proximal end and a distal end; and
a locking element mounted to the distal end of the elongated element and disposed in the distal section of the lumen;
whereby, when the elongated body is disposed in a second object, and a first object extends through the window, and the locking element is thereafter moved proximally, proximal movement of the locking element causes the elongated body to capture the first object to the elongated body, whereby to secure the first object to the second object; and
an inserter, the inserter comprising:
a handle;
a shaft having a distal end and a proximal end, with a lumen extending therebetween, the proximal end of the shaft being mounted to the handle and the distal end of the shaft being configured to releasably engage the elongated body;
a retractable sheath disposed movably coaxially about the shaft; and
a movable tab mounted to the proximal end of the retractable sheath for moving the retractable sheath relative to the shaft.

US Pat. No. 10,136,883

METHOD OF ANCHORING A SUTURE

VentureMD Innovations, LL...

1. A method of repairing soft tissue adjacent a shoulder joint comprising:producing a bone tunnel into a bone, the bone tunnel having at least first and second openings at an exterior surface of the bone;
securing a first suture portion and a second suture portion to soft tissue;
positioning the first suture portion so that the first suture portion extends from the soft tissue to the first opening, then through the first opening, and then through the bone tunnel;
positioning the second suture portion so that the second suture portion extends, outside of the bone tunnel, from the soft tissue;
passing the first suture portion through a first transverse anchor passage in an anchor, the anchor comprising a proximal end and a distal end, the first transverse anchor passage extending transversely into the anchor at the distal end and a second transverse anchor passage extending transversely into the anchor at the proximal end;
passing the second suture portion through the second transverse anchor passage in the anchor;
inserting the anchor into the bone tunnel through the second opening; and
advancing a locking member in sliding translation along a path inside the anchor to compress the first and second suture portions between the locking member and the anchor to secure the first and second suture portions relative to the bone tunnel and the anchor, the first and second suture portions being positioned within the bone tunnel when the first and second suture portions are secured with the locking member, such that the first transverse anchor passage through the distal end substantially aligns with the first opening of the bone tunnel when the first suture portion is secured.

US Pat. No. 10,136,882

SPINAL SURGERY DISTRACTION WITH AN INTEGRATED RETRACTOR

GLOBUS MEDICAL, INC., Au...

1. A surgical method comprising:removing a portion of a disc from a disc space in a patient via an anterior approach;
performing a surgical distraction on vertebrae adjacent the disc space by inserting a combined distractor and retractor assembly in the disc space, wherein the combined distractor and retractor assembly comprises a distractor portion that is mated to a retractor portion; and
removing the distractor portion from the disc space while keeping the retractor portion in the disc space;
wherein the retractor portion is planar.

US Pat. No. 10,136,881

LAPAROSCOPIC RETRACTOR DEVICES

Mayo Foundation for Medic...

1. A laparoscopic retractor device comprising:a handle;
an elongate shaft with a proximal end portion that is attached to the handle, the shaft extending from the handle and terminating at a distal free end portion, the shaft defining a first lumen;
an elongate shaft linkage disposed within the first lumen, the shaft linkage having a proximal end and a distal end;
a first actuator located at the handle and coupled to the proximal end of the shaft linkage;
an expandable portion including: (i) a distal end portion coupled to the distal free end portion of the shaft and (ii) a proximal end portion coupled to the distal end of the shaft linkage, wherein moving the actuator causes the expandable portion to move radially outward from the shaft or radially inward toward the shaft; and
a sheath with a lumen therethrough, at least a portion of the shaft being disposed within the lumen, the sheath being slidable distally and proximally along the shaft.

US Pat. No. 10,136,879

SYSTEM AND METHOD FOR NON-CONTACT ELECTRONIC ARTICULATION SENSING

Covidien LP, Mansfield, ...

1. A surgical instrument, comprising:a handle portion;
a body portion extending distally from the handle portion and defining a first longitudinal axis;
an articulation tool assembly defining a second longitudinal axis and having a proximal end, the articulation tool assembly disposed at a distal end of the body portion and being movable from a first position in which the second longitudinal axis is substantially aligned with the first longitudinal axis to at least a second position in which the second longitudinal axis is disposed at an angle with respect to the first longitudinal axis;
an articulation mechanism configured to articulate the articulation tool assembly, the articulation mechanism including:
an articulation link mechanically engaged to the articulation tool assembly; and
an articulation knob mechanically engaged to the articulation link, wherein rotational motion of the articulation knob is translated into articulation movement of the articulation tool assembly through the articulation link; and
an articulation sensor assembly including:
a photo sensor disposed in spaced relation to the articulation link and configured to detect light reflected from the articulation link, the photo sensor configured to transmit a sensor signal; and
a microcontroller configured to determine an articulation angle of the articulation tool assembly based on the sensor signal.

US Pat. No. 10,136,878

AUTOMATIC DEVICE AND KIT FOR INSERTING A CANNULA TO A PREDETERMINED DEPTH WITHIN A BONE, IRRESPECTIVE OF THE THICKNESS OF THE TISSUE ABOVE THE BONE

WAISMED LTD., Herzliya (...

1. An automatic device for causing penetration of a stylet and cannula to a predefined depth ? within a bone, said depth ? being irrespective of a thickness of tissue above the bone, said device comprising:a) a trigger unit for activating the device;
b) a barrel;
c) a probe unit positioned within said barrel which is driven by a secondary spring, said probe unit comprises one or more probing needles at a distal end, and an anvil at a proximal end for defining an end of movement location for a hammer unit;
d) said hammer unit which is driven by a main spring and comprises a stylet which is longer than said one or more probing needles at its distal end, a core at its proximal end, and a piston between said core and stylet;
e) a cannula within which said stylet is inserted; and
f) one or more grasping units;
wherein when said hammer unit is positioned at said end of movement location, a tip of said stylet is located a distance ? farther in a distal direction from respective ends of said probing needles,
wherein said secondary spring, when released in response to activation of said trigger unit, is configured to push said one or more probing needles of said probe unit toward the bone, up to a point of contact with a surface of the bone,
wherein said one or more grasping units are configured to grasp the anvil of said probe unit, upon contact between said one or more probing needles and the bone surface,
wherein said main spring, when released in response to the activation of said trigger unit, is configured to push said hammer unit to said end of movement location and thereby cause penetration of said cannula to a depth of ? within the bone.

US Pat. No. 10,136,877

ULTRASOUND DIAGNOSIS APPARATUS AND IMAGE PROCESSING APPARATUS

Toshiba Medical Systems C...

1. An ultrasound diagnosis apparatus, comprising:processing circuitry configured to
generate three-dimensional image data based on reflected-wave data received by an ultrasound probe,
generate a two-dimensional tomographic image using the three-dimensional image data,
set a value of an image quality adjusting parameter used for generating a virtual endoscopic image so that a position of an internal wall of a lumen in the three-dimensional image data matches a corresponding position of the internal wall of the lumen in the two-dimensional tomographic image or so that a distance between two points on opposing sides of the internal wall of the lumen in the three-dimensional image data is equal to a corresponding distance between two points set in the two-dimensional tomographic image;
generate the virtual endoscopic image by projecting an inside of the lumen from a predetermined viewpoint and using the value of the set image quality adjusting parameter; and
cause a predetermined display to display the virtual endoscopic image.

US Pat. No. 10,136,876

SYSTEM AND METHOD FOR LOCAL ESTIMATION OF NONLINEAR TISSUE ELASTICITY WITH ACOUSTIC RADIATION FORCE

MAYO FOUNDATION FOR MEDIC...

1. A method for forming an image representing a locally determined nonlinear elastic parameter of a subject with an ultrasound system, the method comprising:a) irradiating the subject with a first ultrasound beam generated by a transducer of the ultrasound system to form a target acoustic radiation force in an origin region of the subject,
wherein the target radiation force has a component that is non-linear with respect to an amplitude of said first ultrasound beam;
b) transforming said first ultrasound beam into a second ultrasound beam generated by said transducer and focused at a detection point of the subject, said detection point being spatially separated from the origin region in a direction transverse to the first ultrasound beam;
c) with said ultrasound system, detecting ultrasound energy reflected from at least two detection points of the subject by irradiating said at least two detection points with the second ultrasound beam while temporally multiplexing said first and second ultrasound beams without mechanical repositioning of said transducer to avoid using another transducer in said ultrasound system,
d) with a programmable processor, operably cooperated with the ultrasound system, determining, from the detected ultrasound energy, echo data indicative of a target shear wave induced in said subject locally, at the origin region, by said target acoustic radiation force,
said target shear wave propagating from said origin region towards said at least two detection points;
determining, from said echo data, a target shear wave displacement;
determining, from the echo data, target parameters of the target shear wave,
said target parameters including at least one of speed and attenuation of the target shear wave;
calculating a normalized shear wave displacement induced in said subject locally, at the origin region, by a normalized acoustic radiation force formed by irradiating said origin region with said first ultrasound beam under normalization conditions,
wherein said normalization conditions are defined by having a unit peak intensity of said first ultrasound beam at a boundary of said transducer;
wherein said calculating includes calculating the normalized shear wave displacement ?sim(x,x0) according to
?sim(x,x0)=?D(x?y)ARF(y,x0)dy,
wherein ARF(y,x0) is normalized radiation force evaluated at point y with x0 being a position of a focal point of the transducer, G is an elastodynamic Green's function, and a volume integral is computed over the origin region D;
e) with the ultrasound system, measuring said nonlinear elastic parameter at the origin region of the subject based on a mean ratio of said target shear-wave displacement to said normalized shear wave displacement, said mean ratio SC(x0) expressed according to a product

wherein S is a peak input intensity, |uobs(xk,x0)| is a measured peak of the normalized shear wave displacement at a measurement point xk, C is a nonlinearity parameter, and a variable x0 denotes a position of the origin region D and a point in a tissue at which the nonlinearity parameter C is evaluated, k is an index of summation, and n is an upper bound of summation;
and
based on the measured nonlinear elastic parameter, spatially differentiating a malignant tissue of the subject from a benign tissue of the subject.

US Pat. No. 10,136,875

ULTRASONIC DIAGNOSTIC APPARATUS AND ULTRASONIC DIAGNOSTIC METHOD

Konica Minolta, Inc., To...

1. An ultrasonic diagnostic apparatus that decides a type of a tumor contained in a specimen, the apparatus comprising:an image forming unit that forms an ultrasonic image corresponding to an echo signal received from the specimen after administration of a contrast medium;
a feature value calculating unit that classifies each of a plurality of pixel regions contained in a tumor region including the tumor in the ultrasonic image into a low-luminance region, or a high-luminance region having higher luminance than the luminance of the low-luminance region, and calculates, based on a difference between a variance at a position of the low-luminance region and a variance at a position of the high-luminance region, a ring level indicating a degree of a ring shape of an image of the tumor region, the ring shape in which a luminance value of a central portion is lower than a luminance value of a peripheral portion surrounding the central portion; and
a type deciding unit that decides the type of the tumor based on the ring level.

US Pat. No. 10,136,874

X-RAY IMAGING APPARATUS

Vieworks Co., Ltd., Anya...

1. An X-ray imaging apparatus comprising:a bias voltage source that provides a bias voltage to pixels that detect X-rays; and
an automatic exposure control (AEC) processing unit that detects a current flowing between the bias voltage source and the pixels and outputs an AEC signal,
wherein the bias voltage source provides the bias voltage to photodiodes included in the pixels through a common electrode, and the AEC processing unit detects a current flowing between the common electrode and the bias voltage source,
wherein the AEC processing unit includes:
a detector that detects the current and converts into a voltage signal; and
an output unit that outputs an AEC signal depending on a voltage output by the detector,
wherein the detector includes a switch that allows bypassing the current, and
wherein the switch is configured to be open when the X-ray imaging apparatus performs an integration process and closed when the X-ray imaging apparatus performs a readout process.

US Pat. No. 10,136,873

RADIOGRAPHIC IMAGE PROCESSING DEVICE, METHOD, AND RECORDING MEDIUM

FUJIFILM Corporation, Mi...

1. A radiographic image processing device comprising:at least one hardware processor configured to implement:
a frequency decomposition unit for performing frequency decomposition for a first radiographic image which is captured by irradiating a subject with radiation and acquiring a plurality of band images indicating a plurality of frequency components of the first radiographic image;
a scattered radiation removal unit for calculating a scattered radiation component that is caused by the subject and is included in a second radiographic image of the subject which has a linear relationship with an amount of radiation, using the second radiographic image, and removing the scattered radiation component from the second radiographic image to acquire a scattered-radiation-removed radiographic image;
a conversion function determination unit for determining a conversion function for converting at least one of the band images according to the scattered radiation component included in the second radiographic image;
a conversion unit for converting the at least one band image, using the conversion function, and generating a converted band image; and
a reconstruction unit for reconstructing the scattered-radiation-removed radiographic image and the converted band image to acquire a processed radiographic image,
wherein the first radiographic image has a pixel value that has a linear relationship with a logarithmic amount of radiation, and
wherein the second radiographic image is obtained by performing inverse logarithmic conversion for the first radiographic image.

US Pat. No. 10,136,872

DETERMINATION OF AN X-RAY IMAGE DATA RECORD OF A MOVING TARGET LOCATION

1. A method for determining an x-ray image data record of a target location of a patient subjected to a movement using an x-ray device, the method comprising:recording a plurality of component images of the target location using an image exposure time;
registering the plurality of component images with one another;
determining one or more quality values related to the movement of the target for each component image of the plurality of component images, the one or more quality values including at least a motion speed calculated as a comparison between a spread function of at least two or more of the plurality of component images and a reference spread function of the x-ray device;
selecting as a function of the one or more quality values a contribution of one or more basic images of the plurality of component images; and
combining the one or more component images into the x-ray image data record as a function of the selected contribution of the one or more component images.

US Pat. No. 10,136,871

EXTREMITY IMAGING FOR ANIMALS

Carestream Health, Inc., ...

1. An apparatus for radiographic imaging of an animal, the apparatus comprising:a support base having a top surface to support a four legged animal standing thereon;
a moveable x-ray source disposed within a source housing and mechanically attached to the support base; and
a digital radiographic detector mechanically attached to the support base, wherein the source housing and the detector extend upward substantially perpendicular to, and above, the top surface of the support base, and wherein the x-ray source and the detector are configured to capture a radiographic image of at least one foreleg or hind leg of the standing animal,
wherein the source and the detector are attached to separate, concentric, moveable portions of the top surface of the support base, each of the moveable portions of the top surface of the support base comprising a ring shape coplanar with a plane of the top surface of the support base.

US Pat. No. 10,136,870

EXTREMITY IMAGING FOR ANIMALS

Carestream Health, Inc., ...

1. An apparatus for radiographic imaging of an animal, the apparatus comprising:a floor to support an animal standing on its legs;
a moveable x-ray source disposed above a surface of the floor within a source housing and mechanically attached to a rotation mechanism; and
a digital radiographic detector disposed below the surface of the floor and mechanically attached to the rotation mechanism, wherein the source housing remains stationary, and wherein the x-ray source and the detector are configured to revolve around at least one extremity of the animal to capture at least one radiographic image thereof.

US Pat. No. 10,136,868

FAST DUAL ENERGY FOR GENERAL RADIOGRAPHY

General Electric Company,...

1. A system, comprising:an X-ray source configured to generate X-rays directed toward an object, wherein the X-ray source is to: (i) generate a first energy X-ray pulse, (ii) switch to generate a second energy X-ray pulse, and (iii) switch back to generate another first energy X-ray pulse, wherein the second energy X-ray pulse is associated with higher voltage level as compared to the first energy X-ray pulses;
a detector associated with multiple image pixels, the detector including, for each pixel:
an X-ray sensitive element to receive X-rays,
a first storage element and associated switch to capture information associated with the first energy X-ray pulses, and
a second storage element and associated switch to capture information associated with the second energy X-ray pulse; and
a controller to synchronize the X-ray source and detector.

US Pat. No. 10,136,867

RADIOLOGICAL IMAGING SYSTEM WITH IMPROVED INTERNAL MOVEMENT

IMAGINALIS SRL, Sesto Fi...

1. A radiological imaging system, comprising:a bed;
a load-bearing structure connected to the bed and configured to support the bed; and
a gantry connected to the load-bearing structure, the gantry defining a main axis of expansion, the gantry having a source configured to emit radiation, a detector with a sensitive surface configured to detect the radiation, an internal inner guide configured to rotate the detector around the main axis of expansion defining an inner sliding trajectory, and an internal outer guide configured to rotate the source around the main axis of expansion defining an outer sliding trajectory, wherein the distance from the source to the main axis of expansion is greater than the distance from the detector to the main axis of expansion, and the gantry including a casing housing the source, the detector, the internal inner guide, and the internal outer guide,
wherein the casing includes a fixed arched module, a first mobile arched module, and a second mobile arched module.

US Pat. No. 10,136,866

RADIATION IRRADIATION DEVICE

FUJIFILM Corporation, To...

1. A radiation irradiation device comprising:a radiation generation unit that generates radiation;
an arm part having one end to which the radiation generation unit is attached;
a support member having one end to which the other end of the arm part is connected so as to be rotationally movable;
a body part to which the other end of the support member is connected; and
a leg part on which the body part is placed,
wherein in a case where a side toward which the arm part extends from the body part during use of the device is defined as a front side, the leg part includes a first caster which is provided on the front side of a bottom surface of the leg part and to which a rotating shaft of a wheel is revolvably supported and a second caster which is provided on a rear side of the bottom surface of the leg part and to which a rotating shaft of a wheel is revolvably supported, and
wherein a diameter of the wheel of the second caster is greater than a diameter of the wheel of the first caster, and a gravity center position of the entire device is closer to the second caster side than a center between the first caster and the second caster in a state where the arm part is rotationally moved until the radiation generation unit is located at a vertically lowermost position.

US Pat. No. 10,136,865

RADIOIMAGING USING LOW DOSE ISOTOPE

Spectrum Dynamics Medical...

23. A nuclear medicine imaging system, comprising:a radioactive-emission camera, comprising:
a plurality of independently moveable detecting units;
a plurality of motion transfer systems, equal in number to a number of said detecting units, each of the motion transfer systems being in mechanical communication with one of the detecting unit, for moving each said detecting unit; and
a controller for optimizing said radioactive-emission camera configured to:
model a body structure, based on its geometry;
model anatomical constraints, which limit accessibility to the body structure;
optimize a camera design using said modeled body-structure and said modeled anatomical constraints.

US Pat. No. 10,136,864

X-RAY COLLIMATOR SIZE AND POSITION ADJUSTMENT BASED ON PRE-SHOT

KONINKLIJKE PHILIPS N.V.,...

1. An X-ray apparatus for image acquisition, comprising:an X-ray source configured to generate X-ray radiation for image acquisition of an object;
a collimator comprising at least one moveable shutter, the collimator being configured to collimate the X-ray radiation into a radiation cone, said radiation cone irradiating the object at a region of interest when acquiring an image;
a portable radiation detector configured to register the X-ray radiation after passage through the object; and
a field-of-view corrector configured to receive, in a pre-shot imaging phase, a scout image (SI) acquired by the portable radiation detector with a tentative setting of the collimator, the pre-shot imaging phase causing a low dosage radiation cone to impinge on the portable radiation detector, the low dosage radiation cone having in an image plane of the portable radiation detector a first cross section being smaller than a surface area of the portable radiation detector,
the field-of-view corrector being further configured to use said scout image to establish field-of-view correction information for a subsequent imaging phase, the field of view correction information including collimation correction information for determining a corrected setting of the collimator,
wherein, in the subsequent imaging phase, the corrected setting of the collimator results in a high dosage radiation cone impinging on the portable radiation detector, the high dosage radiation cone providing a higher dosage of radiation than the low dosage radiation cone, and the high dosage radiation cone having, in the image plane of the portable radiation detector, a second cross section that is larger than the first cross section and the high dosage radiation cone i) being essentially coextensive with the surface area of the portable radiation detector or ii) being a symmetric enlargement of the first cross section and extending in its entirety within the surface area of the portable radiation detector.

US Pat. No. 10,136,863

X-RAY-OPTIMIZED DEVICE FOR SUPPORTING A PATIENT

MAQUET GMBH, Rastatt (DE...

1. An apparatus for supporting a patient, comprising:a first structural member having a first end portion and a second end portion, the second end portion of the first structural member being attached to an operating table;
a second structural member having a first end portion and a second end portion, the second end portion of the second structural member being attached to the operating table;
a first connecting member that connects the first end of the first structural member to the first end of the second structural member, the first structural member being disposed at a predetermined distance from the second structural member;
a first support member supported exclusively on the first structural member, the first support member configured to support a body part of the patient; and
a second support member supported exclusively on the second structural member;
wherein the first support member comprises a mounting assembly and is configured to be reversibly locked onto the first structural member, and when not locked is displaceable along the first structural member along a lengthwise direction of the first structural member;
wherein the second support member comprises a mounting assembly and is configured to be reversibly locked onto the second structural member, and when not locked is displaceable along the second structural member along a lengthwise direction of the second structural member independent of the positioning of the first support member on the first structural member;
wherein the first support member comprises a first support pad and a first height adjustment assembly for varying the height of the first support pad with respect to the first structural member when the first support member is mounted to the first structural member;
wherein the second support member comprises a second support pad and a second height adjustment assembly for varying the height of the second support pad with respect to the second structural member when the second support member is mounted to the second structural member;
wherein the first support member and the second support member are spaced apart from one another, a material-free x-ray area being formed between the first support member and the second support member.

US Pat. No. 10,136,862

METHOD OF SONIFYING BRAIN ELECTRICAL ACTIVITY

The Board of Trustees of ...

1. A method of sonifying brain signals using a digital processor system that comprises at least one processing unit, the method comprising:filtering, with a front-end module coupled to the digital processor system, a continuous time-domain sensor signal representing brain activity of a subject obtained from at least one sensor in order to generate a filtered continuous time-domain sensor signal;
producing a continuous time-domain signal representing the brain activity of the subject from the filtered continuous time-domain sensor signal using the digital processor system, the continuous time-domain signal having a time varying signal value;
concurrently generating a plurality of continuously time-varying acoustic parameters from the continuous time-domain signal using the digital processor system, the plurality of continuously time-varying acoustic parameters including a vowel-control parameter, an intensity-control parameter, and a pitch-control parameter, wherein at least three of the parameters in the plurality of continuously time-varying acoustic parameters are continuously modulated in proportion with at least the continuous time varying signal value of the time-domain signal during concurrent generation;
driving, with the digital processor system, an audio synthesizer using the concurrently generated plurality of continuously time-varying acoustic parameters, including the vowel-control parameter, the intensity-control parameter, and the pitch-control parameter, to produce a representation of an acoustic signal corresponding to the brain activity of the subject represented by the continuous time-domain signal;
performing continuous audio playback of the representation of the acoustic signal using the digital processor system, wherein performing the continuous audio playback comprises audibly providing, with at least one speaker, the representation of the acoustic signal for diagnosis and/or treatment of a condition of the subject.

US Pat. No. 10,136,861

SYSTEM AND METHOD FOR PREDICTING ACUTE CARDIOPULMONARY EVENTS AND SURVIVABILITY OF A PATIENT

SINGAPORE HEALTH SERVICES...

1. A patient survivability prediction system comprising:a hand-held device comprising
a first input to receive a first set of parameters relating to heart rate variability data of a patient based on electrocardiogram (ECG) signals from a patient, and
a second input to receive a second set of parameters relating to vital sign data of the patient;
a memory module to store the first set of parameters and the second set of parameters;
a third input to receive a third set of parameters including at least one of demographic information of the patient and medical history information of the patient;
at least one processor coupled to the memory module and configured to analyze the first set of parameters, the second set of parameters, and the third set of parameters and output a prediction on the survivability of the patient over a predetermined period of time based on the first set of parameters, the second set of parameters, and the third set of parameters; and
a display coupled to the at least one processor to display the prediction on the survivability of the patient over the predetermined period of time.

US Pat. No. 10,136,859

SYSTEM AND METHOD FOR OUTPATIENT MANAGEMENT OF CHRONIC DISEASE

1. An outpatient ambulatory patient worn apparatus for managing chronic lung disease comprising:a plurality of sensors configured to be worn by a patient and to measure a plurality of physiological data, said plurality of sensors including at least one oximeter, a respiratory rate sensor, and at least one activity or motion sensor, at least said oximeter, said at least one oximeter, said respiratory rate sensor, and said at least one activity or motion sensor continuously operative to measure said plurality of physiological data in an outpatient setting during activities of daily living comprising rest, exertion, and sleep;
a central monitoring unit (CMU) communicatively coupled to said plurality of sensors and to an interface device, said CMU comprising a computer, and said CMU to be worn by the patient in said outpatient setting during activities of daily living, said CMU programmed to record concurrently a set of time stamped primary data comprising measurement data from each of said plurality of sensors to a non-volatile memory at a predetermined interval for one or more epochs of time, and to categorize at an acquisition rate or some multiple of the acquisition rate each recorded measurement of each of said plurality of sensors stored in said set of time stamped primary data by a predominate activity type to generate a set of activity type stamped data, said predominate activity type selected from a plurality of activity types including rest, exertion, and sleep; and
a generate report process running on said CMU to provide at least one or more reports in real time including at least an indication or determination of whether a chronic lung disease treatment is needed by the patient based on said set of activity type stamped data.

US Pat. No. 10,136,858

METHOD FOR INSPECTING PRESSURE PULSE WAVE SENSOR AND METHOD FOR MANUFACTURING PRESSURE PULSE WAVE SENSOR

OMRON HEALTHCARE Co., Ltd...

1. A method for inspecting a pressure pulse wave sensor which includes a sensor chip and a substrate, the sensor chip including a pressure-sensitive element array constituted by a plurality of pressure-sensitive elements arranged in one direction, the sensor chip put into use so that a pressure-sensitive face of the sensor chip where the pressure-sensitive element array is formed is pressed against a body surface of a living body in a state in which the one direction intersects with a traveling direction of an artery of the living body, the sensor chip fixed to the substrate, whereinthe substrate includes a through hole and a substrate-side terminal portion,
the sensor chip includes a recess which is recessed in a direction perpendicular to the pressure-sensitive face and on an opposite side to the pressure-sensitive face, and the pressure-sensitive element array is formed on the pressure-sensitive face in a portion of the sensor chip whose thickness is reduced in the perpendicular direction due to the recess, and
the sensor chip further includes a chip-side terminal portion which is electrically connected to the pressure-sensitive element array and which is provided at one or each of opposite ends of the pressure-sensitive element array extending in the one direction,
the method comprising:
bonding and fixing the sensor chip onto the substrate so that the recess communicates with atmospheric air through only the through hole of the substrate;
connecting the substrate-side terminal portion of the substrate to which the sensor chip is bonded and fixed, and the chip-side terminal portion through an electrically conductive member;
covering the electrically conductive member with a protective member; and
performing characteristic evaluation about a variation among the plurality of pressure-sensitive elements of the sensor chip, after covering the electrically conductive member with the protective member, based on a signal outputted from the substrate-side terminal portion in a state in which air is sucked through the through hole of the substrate to thereby apply negative pressure to the pressure-sensitive face.

US Pat. No. 10,136,857

ADJUSTABLE WEARABLE SYSTEM HAVING A MODULAR SENSOR PLATFORM

Samsung Electronics Co., ...

1. A wearable system for measuring physiological data from a device worn about a body part of a user comprising:a base module, the base module comprising a display and a base computing unit, and being positioned on a first side of the body part;
a first sensor module configured to measure a gravitational force experienced by the device;
a second sensor module spatially positioned relative to the base module on a second side opposite to the first side of the body part and over a portion of the body part for measuring one or more physiological characteristics calibrated based on the gravitational force measured with the first sensor module; and
the base module being adjustably positioned on the body part relative to the second sensor module so that the second sensor module maintains its positioning over the body part for sufficient contact with the body part regardless of an anthropometric size of the body part.

US Pat. No. 10,136,856

WEARABLE RESPIRATION MEASUREMENTS SYSTEM

Facense Ltd., Kiryat Tiv...

1. A system configured to collect thermal measurements related to respiration, comprising:a frame configured to be worn on a user's head; and
at least one thermal camera that is physically coupled to the frame; wherein the frame is configured to hold the at least one thermal camera less than 15 cm away from the user's face, such that the at least one thermal camera does not occlude any of the user's mouth and upper lip;
wherein the at least one thermal camera is configured to take thermal measurements of: a portion of the right side of the user's upper lip (THROI1), a portion of the left side of the user's upper lip (THROI2), and a portion of the user's mouth (THROI3).

US Pat. No. 10,136,855

AUTOMATIC ADJUSTMENT OF HELMET PARAMETERS BASED ON A CATEGORY OF PLAY

INTERNATIONAL BUSINESS MA...

1. A method for automatic adjustment of helmet parameters based on a category of play, the method comprising:monitoring a plurality of sensors in a helmet;
determining the category of play for a user of the helmet based on data received from the plurality of sensors; and
automatically adjusting parameters of the helmet based on the category of play, wherein the parameters include at least one of a stiffness, a size and a shape of a padding of the helmet,
wherein a type of an adjustment and an amount of the adjustment are determined based on a model of expected risks for the category of play for the user.

US Pat. No. 10,136,854

STRETCHABLE THERMOELECTRIC MATERIAL AND THERMOELECTRIC DEVICE INCLUDING THE SAME

Samsung Electronics Co., ...

1. A thermoelectric material, comprising:a stretchable polymer; and
a thermoelectric structure and electrically conductive material that are mixed together in the stretchable polymer, the thermoelectric structure including a carbon-containing material, wherein
the carbon-containing material includes carbon nanotubes,
the carbon nanotubes are arranged in an array, and
lengths of the carbon nanotubes are parallel to each other.

US Pat. No. 10,136,853

CONTACTLESS SLEEP DISORDER SCREENING SYSTEM

KONINKLIJKE PHILIPS N.V.,...

1. A system configured to monitor a sleep session of a patient without making physical contact with the patient, the system comprising:a sound sensor configured to generate output signals that convey information related to sound originating from the patient in a sleeping environment;
a movement sensor comprising:
a light source configured to project a structured light pattern onto the patient which deforms when the patient moves; and
a detector configured to receive light reflected from the patient, the detector configured to generate output signals that convey information related to changes in the structured light pattern projected onto the patient caused by movement of the patient; and
one or more hardware processors configured by machine-readable instructions to:
receive and store data relating to the sound originating from the patient based on the information conveyed by the output signals from the sound sensor,
determine movement of the patient based on (1) a distance between the light source and the detector, and (2) a change in angle of reflected light from the structured light pattern received from an individual moving point on the patient, wherein images derived from the information related to changes in the structured light pattern are construed wherein an indication of motion vectors is provided, wherein the motion vectors indicate a direction and an amplitude of the movement of the patient, wherein the motion vectors facilitate segmentation of one or more body parts, and wherein information related to a mouth movement is determined based on the segmentation of the one or more body parts, and
determine a sleep disorder diagnosis based on the sound originating from the patient and the movement of the patient, wherein the one or more hardware processors are configured to determine parasomnia Bruxism based on the determined mouth movement.

US Pat. No. 10,136,852

DETECTING AN ALLERGIC REACTION FROM NASAL TEMPERATURES

Facense Ltd., Kiryat Tiv...

1. A system configured to detect allergic reaction, comprising:an inward-facing head-mounted thermal camera (CAM) configured to take thermal measurements of a region on the nose (THN) of a user; and
a computer configured to: generate feature values based on THN, and utilize a machine learning-based model to detect an allergic reaction of the user based on the feature values; wherein the machine learning-based model was trained based on previous THN taken during different days.

US Pat. No. 10,136,851

INTEGRATED DEVICE TO MEASURE VARIATIONS IN NEUROMUSCULAR CONTROL WHEN TRACING DEFINED TARGET PATTERNS AND A SYSTEM AND METHOD OF USING THE INTEGRATED DEVICE

1. A device for measuring variations in neuromuscular control of a user, comprising:an integrated device, including:
a computing device configured to be held by the user;
a pointing device attached to, or integrated with the computing device, the pointing device including an end portion;
the computing device configured to detect three-dimensional movement data of the integrated device relative to a particular pattern predefined in the computing device while the user is tracing the pattern;
wherein the pointing device is configured for the end portion to be pointed at said pattern at a predefined distance from said pattern to trace said pattern, without the end portion physically touching the pattern.

US Pat. No. 10,136,850

BIOLOGICAL STATE ESTIMATION DEVICE, BIOLOGICAL STATE ESTIMATION SYSTEM, AND COMPUTER PROGRAM

Delta Tooling Co., Ltd., ...

1. A biological body state estimation device for estimating a state of fatigue of a person using a biological signal obtained from an upper body of the person, comprising:an air pack configured to be brought into contact with a back part of the person and whose pressure has a pressure fluctuation that fluctuates with fluctuation in the aorta caused by movement of the heart, the air pack being further configured to output the pressure fluctuation as the biological signal; and
circuitry in electronic communication with the air pack and configured to
receive the biological signal from the air pack;
analyze the biological signal, and acquire and sort a homeostatic function level of the person at a predetermined point of time into a plurality of stages;
plot the homeostatic function level in a time series by taking each stage of the homeostatic function level on a vertical axis and time on a lateral axis and display a fluctuation degree of the homeostatic function level on a display circuit as a graph; and
determine the state of fatigue from the homeostatic function level;
wherein the circuitry is configured to analyze the biological signal and acquire and sort the homeostatic function by:
acquiring a frequency of the biological signal;
conducting a movement calculation to acquire a slope of the frequency for each predetermined time window set with a predetermined overlapped time from the frequency of the biological signal and acquiring a time-series waveform of the slope of the frequency obtained for each time window;
differentiating the time-series waveform of the slope of the frequency;
integrating the time-series waveform of the slope of the frequency;
acquiring a rectangular wave from an increase/decrease of the time-series waveform of the slope of the frequency;
acquiring a describing function and a describing function amplitude value between the time-series waveform of the slope of the frequency in an arbitrarily set first time zone and the time-series waveform of the slope of the frequency in a second time zone after the first time zone;
applying absolute value processing to the time-series waveform of the respective slopes of the frequency by using a time-series waveform of the frequency of the biological signal using a maximum value of the time-series waveform of the biological signal and a time-series waveform of the frequency of the biological signal using a zero-crossing point where the sign of the time-series waveform of the biological signal is switched; and
acquiring the stage of the homeostatic function level by determining whether at least two indices indicate a characteristic change, wherein the at least two indices have the characteristic change according to said each stage of the homeostatic function level and are chosen independently for said each stage of the homeostatic function level, the at least two indices comprising at least two of the slope of the frequency, the differential value, the integral value, the sign of the rectangular wave, the describing function amplitude value, and two absolute values of the time-series waveform of the slope of the frequency.

US Pat. No. 10,136,849

BIOLOGICAL FLUID COLLECTION DEVICE AND BIOLOGICAL FLUID SEPARATION AND TESTING SYSTEM

Becton, Dickinson and Com...

1. A biological fluid separation device, comprising:a rotatable body having a center of rotation and an outer periphery, the rotatable body having a body inlet adapted to receive a multi-component blood sample;
a separation chamber defined within the rotatable body and in fluid communication with the body inlet and having a chamber outlet spaced apart from the body inlet, the separation chamber adapted to receive both the multi-component blood sample; and
a blood component chamber defined within the rotatable body and in fluid communication with the chamber outlet, wherein when the separation chamber contains the multi-component blood sample and a rotational force is applied to the rotatable body, a blood component of the multi-component blood sample passes from the separation chamber into the blood component chamber and a second component of the multi-component blood sample is retained within the separation chamber,
wherein the blood component chamber is disposed adjacent the center of rotation and the separation chamber is disposed adjacent the outer periphery of the rotatable body.

US Pat. No. 10,136,848

DEVICE AND SYSTEM OF BLOOD COLLECTION, AND METHOD THEREOF

Winnoz Technology, Inc., ...

1. A device for collecting a blood sample, comprising:a collection unit comprising:
a top window;
a top surface;
a channel communicated with the top window;
at least one capillary tube having a top end adjacent to the top window;
wherein a distance between the top end of the at least one capillary tube and the top surface of the collection unit is in a range of 1.0 mm to 5.0 mm, such that the top end of the at least one capillary tube is used to contact with a blood drop from a puncture to continuously draw the blood flowing inside or along the at least one capillary tube into a storage unit by disrupting a surface tension of the blood drop, and
a vacuum connector communicated with the channel, extended outwardly from the collection unit, and connected to a pressure control unit to remove air from the channel and create an alternating negative pressure in the channel; and
the storage unit disposed under the collection unit.

US Pat. No. 10,136,847

MITIGATING SINGLE POINT FAILURE OF DEVICES IN AN ANALYTE MONITORING SYSTEM AND METHODS THEREOF

Abbott Diabetes Care Inc....

1. A computer-implemented method for mitigating single point failure of at least one device in an analyte monitoring system, comprising:providing a request, from a first device to a second device, that a functionality check of one or more components of a third device be performed, wherein the functionality check includes communicating, from the third device to the second device, data related to results of the functionality check;
receiving, at the first device, the data related to the results of the functionality check from the second device;
determining, by the first device, that the one or more components of the third device is not functioning in accordance with at least one predetermined criterion; and
providing, to the second device, a request from the first device that an alarm function be initiated to alert a user that the one or more components of the third device is not functioning in accordance with the at least one predetermined criterion.

US Pat. No. 10,136,846

MICRONEEDLE ARRAYS FOR BIOSENSING AND DRUG DELIVERY

The Regents of the Univer...

1. An analyte-selective sensor device, comprising:a substrate that includes at least one microneedle with a hollowed interior, wherein the at least one microneedle comprises an interior wall with an opening to the hollowed interior;
an electrode comprising a probe, wherein the probe is disposed inside the hollowed interior and spaced away from the interior wall, wherein the electrode is functionalized by a coating comprising an enzyme-functionalized coating or an ion-selective coating over at least the probe to interact with an analyte to produce an electrical signal; and
a wire electrically coupled to the probe operable to transfer the electrical signal.

US Pat. No. 10,136,845

DEVICES, SYSTEMS, AND METHODS ASSOCIATED WITH ANALYTE MONITORING DEVICES AND DEVICES INCORPORATING THE SAME

ABBOTT DIABETES CARE INC....

1. An apparatus for receiving analyte data from an in vivo analyte sensing device, comprising:a housing;
a display mounted on the housing;
an input component;
a test strip port;
a processor mounted in the housing; and
a memory storing instructions which, when executed by the processor, cause the processor to:
navigate from a current user interface screen on the display to a home screen in response to a press of the input component by a user unless a test strip is in the test strip port and a test strip result has not yet been computed;
cause display of the home screen, wherein the home screen includes an indication of the time remaining until the in vivo analyte sensing device expires; and
cause display of received analyte information,
wherein the instructions, when executed by the processor, cause the processor to render inactive the press of the input component by the user to navigate from the current user interface screen on the display to the home screen if the test strip is in the test strip port and the test strip result has not yet been computed.

US Pat. No. 10,136,844

DUAL ELECTRODE SYSTEM FOR A CONTINUOUS ANALYTE SENSOR

DexCom, Inc., San Diego,...

1. A continuous glucose sensor configured and arranged for insertion into a host for and detecting glucose in the host, the sensor comprising:a first working electrode comprising a first resistance domain, wherein the first working electrode is configured to generate a first signal having a first noise component related to a noise-causing species;
a second working electrode comprising a second resistance domain, wherein the second working electrode is configured to generate a second signal having a second noise component related to the noise-causing species; and
a third resistance domain disposed continuously over the first resistance domain and the second resistance domain,
wherein each of the first resistance domain and the second resistance domain is independently formed on the first working electrode and the second working electrode, respectively.

US Pat. No. 10,136,843

AUDIOLOGIC TEST APPARATUS, SYSTEM AND RELATED METHOD

Natus Medical Incorporate...

12. An audiologic test system for performing an audiologic test, the audiologic test system comprising:an audiologic test apparatus comprising:
a housing;
a processing unit in the housing;
a tone generator connected to the processing unit, the tone generator being instructed by the processing unit to generate a first electrical signal and a second electrical signal;
a probe interface for connecting the audiologic test apparatus to a test probe; and
a pump module having a pressure sensor connected to the processing unit;
a first speaker connected with the audiologic test apparatus; and
a first microphone connected with the audiologic test apparatus;
wherein the processing unit is configured to:
provide a first signal with a first primary frequency component at a first primary frequency through the first speaker, the first electrical signal is representative of the first signal;
obtain a first response signal from the probe interface through the first microphone;
determine if a first insertion criterion is satisfied based on the first signal and the first response signal;
modify pressure in an ear canal;
detect a pressure response utilizing the pressure sensor;
determine if a second insertion criterion is satisfied; and
initiate the audiologic test to examine at least one part of an auditory system of a user if the first insertion criteria and the second insertion criterion are satisfied, the audiologic test includes generation of the second signal with a second primary frequency component at a second primary frequency, the second electrical signal is representative of the second signal;
wherein the audiologic test apparatus is configured to receive an input generated using the pressure sensor and determines if the second insertion criterion is satisfied based on the input thereby indicating proper insertion of the test probe in the ear canal to examine the at least one part of the auditory system of the user.

US Pat. No. 10,136,842

FOOTWEAR APPARATUS WITH TECHNIQUE FEEDBACK

1. A footwear apparatus comprising:a sensor in the footwear apparatus positioned to monitor an activity technique of a user when the footwear apparatus is joined with a foot of the user, and
a feedback generator arranged to produce a haptic communication to the user in response to detecting a pattern in the activity technique, the haptic communication arranged to cause at least some discomfort to the user, wherein the pattern includes a pronation element.

US Pat. No. 10,136,841

MULTI-FUNCTIONAL SMART MOBILITY AID DEVICES AND METHODS OF USE

CAN Mobilities, Inc., Sa...

1. A multifunctional smart cane, comprising:a handle adapted to be gripped by a hand of a user;
a body having a base on one end and coupled to the handle on the other;
a light operable by a light sensor;
a display built into the handle wherein the display is visible to the user while gripping the handle;
one or more activity tracking components carried by the smart cane for collecting information about the user's daily activity;
an electronic memory for storing the collected information about the user's daily activity; and
one or more electronic communication components to transmit the user's daily activity from the electronic memory in the smart cane to another electronic device.

US Pat. No. 10,136,840

FITNESS TRAINING SYSTEM FOR MERGING ENERGY EXPENDITURE CALCULATIONS FROM MULTIPLE DEVICES

NIKE, Inc., Beaverton, O...

1. An apparatus for use with a user performing an exercise comprising:at least one processor;
a first sensor configured to monitor a first exercise performed by the user;
a communication circuit configured to communicate at least energy expenditure information between the apparatus and at least a second device, the energy expenditure information including at least a first energy expenditure estimate corresponding to the first exercise monitored by the first sensor and a second energy expenditure estimate corresponding to a second exercise monitored by at least the second device;
at least one tangible memory storing computer-executable instructions that, when executed by the at least one processor, cause the apparatus at least to:
monitor, with the sensor, the first exercise performed by the user;
receive, from an imaging device, an image of the user performing the first exercise wherein the image includes at least one measurement position on a body of the user;
identify, based on the image, a user movement being performed during the first exercise;
automatically communicate the energy expenditure information between the apparatus and at least the second device after determining a completion of at least one of the first exercise and the second exercise;
determine, by the at least one processor, the first energy expenditure estimate of the user corresponding to the monitored first exercise and the identified user movement;
communicate, by the communication circuit, energy expenditure information between the apparatus and at least the second device after expiration of a specified time interval, the energy expenditure information including the first energy expenditure estimate and the second energy expenditure estimate; and
determine, by the at least one processor, a combined energy expenditure estimate of the user based, at least in part, on the first energy expenditure estimate and the second energy expenditure estimate.

US Pat. No. 10,136,839

AIRWAY ADAPTOR

NIHON KOHDEN CORPORATION,...

1. An airway adaptor adapted to be attached to a mask, the mask adapted to be attached to a face of a living body, the airway adaptor comprising:an airway case;
an expired gas guiding portion which is connected to the airway case to introduce a respiratory gas to the airway case;
a partition wall;
an elongated first passage adapted to introduce the respiratory gas from the expired gas guiding portion to the airway case; and
an elongated second passage adapted to discharge the respiratory gas from the elongated first passage, which has been introduced to the airway case and returned in the airway case without being communicated with the expired gas guiding portion, to outside of the airway case,
wherein the partition wall partitions the elongated first passage and the elongated second passage such that a portion of the elongated first passage is parallel to a portion of the elongated second passage,
wherein the respiratory gas in the portion of the elongated first passage flows in a first direction and the respiratory gas in the portion of the elongated second passage flows in a second direction opposite and in reverse with respect to the first direction,
wherein the airway case includes a respiratory gas flow path through which the respiratory gas passes, the respiratory gas flow path including:
the elongated first passage in which the respiratory gas flows in the first direction; and
the elongated second passage in which the respiratory gas flows in the second direction opposite and in reverse with respect to the first direction,
the elongated first passage and the elongated second passage being connected to each other in an opening of the airway case, and
wherein, when the mask is attached to the face of the living body, at least a part of the airway case that includes the opening in which the elongated first passage and the elongated second passage are connected is projected to an outside of a shell of the mask.

US Pat. No. 10,136,838

PERSONAL SPIROMETER

PMD Healthcare, Lansdale...

1. A hand-held spirometer for correlating test results with a medical condition, said spirometer comprising:a portable housing having handles configured for said user to grip said handles to hold said housing during use;
a display on a surface of said housing;
an airflow tube through said housing;
one or more air flow sensors associated with said airflow tube;
a processor in said housing;
memory operatively connected to said processor and configured with instructions to instruct the processor to perform the following steps:
determining and recording sequential lung performance values based on data from said air flow sensors over a period;
recording user data during said period, said user data comprising at least medical compliance;
correlating said sequential lung performance values and said user data over said period; and
displaying a relationship between said sequential lung performance data and said medical compliance over said period on said display; and wherein said relationship on said display comprises a plot of lung performance per increment of time during said period with an indication of medical compliance for each said increment of time during said period.

US Pat. No. 10,136,837

DEVICE AND METHOD FOR THE ANALYSIS OF THE AIR EXHALED BY A SUBJECT IN ORDER TO MEASURE THE BASAL METABOLISM THEREOF

COSMED S.r.l., Roma (IT)...

1. Device for the analysis of the air exhaled by a subject in order to measure basal metabolism of the subject, the device comprising:a main line, for passage of a sampling flow of the air exhaled by the subject,
a suction pump having a substantially constant flow rate, said pump being arranged downstream of the main line, for drawing said sampling air flow into the main line,
a mixing mini-chamber interposed in the main line upstream of the suction pump for accumulating or mixing with each other a plurality of air sampling flows exhaled by the subject within a number of respiratory cycles,
a by-pass line arranged in parallel to the mixing mini-chamber through which the air flow can flow without passing through said mixing mini-chamber,
a by-pass valve interposed in the main line downstream of the mixing mini-chamber and selectively displaceable in two different positions for causing the airflow through the main line to flow either through the mixing mini-chamber or through said by-pass line,
first sensor means for sensing the oxygen concentration and second sensor means for sensing the carbon dioxide concentration, said first and second sensor means being arranged in the main line between said by-pass valve and the suction pump, for measuring the oxygen concentration and the carbon dioxide concentration within the air flow through the main line downstream of the mixing mini-chamber,
a first switching valve for switching the suction inlet of the suction pump between a condition of connection to said first and second sensor means and a condition in which this connection is interrupted,
flow measuring means for detecting the flow rate of the air inhaled or exhaled by the subject, and
an electronic controller configured for:
receiving and processing signals emitted by said first sensor means of the oxygen concentration, by said second sensor means of the carbon dioxide concentration and by said flow measuring means so as to obtain a measurement of oxygen consumption and carbon dioxide production by the subject within a number of respiratory cycles,
wherein said device further comprises:
a first inlet connector connected to a system for taking a flow of air exhaled by a subject who breathes spontaneously,
a second inlet connector connected through a sampling line to a system for taking a flow of air exhaled by a subject undergoing assisted pulmonary ventilation,
a selection valve interposed in the main line upstream of the mixing mini-chamber for selectively connecting said first connector or said second connector to said main line,
said selection valve having an outlet connected to the main line, a first inlet connected to said first connector and the second inlet for connection to said second connector,
a calibration line, which receives a calibration flow, to be used for calibrating said first and second sensor means for sensing the oxygen concentration and the carbon dioxide concentration,
a second switching valve adapted to be switched between a sampling state and a calibration state, said switching valve being controlled by said electronic controller for selectively connecting said second inlet of said selection valve to said sampling line connected to said second connector or to said calibration line,
a plurality of selector valves distributed in series along said calibration line for selectively connecting the calibration line each time to one only among a plurality of auxiliary lines adapted to provide respective calibration data,
said electronic controller being configured so that, during normal operation of the device, the selection valve is switched for feeding to the main line either a sampling flow of the air exhaled by a subject who breathes spontaneously or by a subject which undergoes assisted pulmonary ventilation, said by-pass valve being in a position causing the airflow to pass through said mixing mini-chamber so that said electronic controller is able to perform said processing in order to obtain said measurement of the oxygen consumption and the carbon dioxide production by the subject within a number of respiratory cycles,
said electronic controller being further programmed for automatically starting, upon switching on the device, a self-calibration stage of the device in which:
the second switching valve communicates said second connector of said selection valve to said calibration line while the selection valve communicates its second inlet to said main line, so that the main line enters into communication with said calibration line,
said electronic controller being configured so that in said self-calibration stage the by-pass valve is in a position which causes said sampling flow of the air exhaled by the subject to flow through said by-pass line, without passing through said mixing mini-chamber, whereby the self-calibration stage can be carried out immediately on the basis of the flow coming from said calibration line, without requiring a filling of said mixing mini-chamber.

US Pat. No. 10,136,836

IMMUNITY FROM MAGNETIC DISTURBANCE FOR A MAGNETIC LOCATION TRACKER

BIOSENSE WEBSTER (ISRAEL)...

1. A magnetic tracking system for positioning of instruments during a medical procedure on the head of a patient comprisinga ferromagnetic sheet;
a frame having an opening for surrounding a patient's head;
said frame mounted in proximity to the ferromagnetic sheet and having at least one radiator mounted therein
said at least one radiator having at least one coil for producing an alternating magnetic field which induces a respective magnetic image of the coil in the ferromagnetic sheet and wherein the magnetic image acts as a magnetic field radiator; and
a solid sheet of thermal insulation, mounted between the ferromagnetic sheet and the at least one radiator so as to prevent transfer of thermal energy from the at least one radiator to the ferromagnetic sheet.

US Pat. No. 10,136,834

NEURONAL RESONANCE MAGNETIC RESONANCE IMAGING METHOD

KOREA ADVANCED INSTITUTE ...

1. A magnetic resonance signal processing method for detecting a magnetic field oscillation signal, the method comprising:obtaining N pieces of MRI (magnetic resonance imaging) data by repeating a step of obtaining an MRI data with an MRI scheme using a gradient magnetic field pattern N number of times while changing relative phases between the gradient magnetic field pattern and the magnetic field oscillation signal; and
calculating a value related to an energy of a predetermined frequency component of an arranged signal produced by arranging the obtained N pieces of MRI data on a time-axis according to the relative phases,
wherein the N pieces of MRI data are K-space data or the N pieces of MRI data are MRI image data.

US Pat. No. 10,136,833

IMPLANTABLE RADIO-FREQUENCY SENSOR

ZOLL MEDICAL ISRAEL, LTD....

1. A diagnostic apparatus, comprising:a sealed case, comprising a biocompatible material and configured for implantation within a body;
a first antenna and a second antenna, each antenna configured to:
be implanted in the body in proximity to a target tissue,
generate and transmit radio frequency (RF) electromagnetic waves through the target tissue to the other antenna, and
output a signal in response to RF waves received from the other antenna; and
processing circuitry, which is contained within the case and is configured to receive and process the signal from each antenna so as to derive and output an indication of a characteristic of the target tissue.

US Pat. No. 10,136,832

REAL-TIME STIMULATION ARTIFACT SUPPRESSION FOR SIMULTANEOUS ELECTROPHYSIOLOGICAL ELECTRICAL STIMULATION AND RECORDING

THE REGENTS OF THE UNIVER...

1. An electrophysiological electrical stimulation and recording apparatus with stimulation artifact suppression, comprising:(a) a control circuit configured for controlling stimulus generation, artifact suppression and recording of a response to the generated stimulus;
(b) a current mode neural stimulator coupled to said control circuit, for amplifying an output from the control circuit to a recording/STI electrode;
(c) a first response amplification stage configured for amplifying the difference between a reference electrode and said recording/STI electrode as a measured stimulus response signal without amplifier saturation;
(d) a second response amplification stage configured for amplifying the difference between said measured stimulus response signal and a subtraction signal selected by said control circuit;
(e) wherein said control circuit is configured for:
(i) setting said subtraction signal to a fixed reference voltage;
(ii) generating a stimulus signal to said stimulus amplifier and storing an output from said second response amplification stage as a first artifact template;
(iii) calibrating the first artifact template by generating a stimulus signal to said stimulus amplifier while outputting said first artifact template as said subtraction signal to said second response amplification stage whose output is used to calibrate said first artifact template as a second artifact template; and
(iv) performing simultaneous stimulation and measurements by outputting said second artifact template as said subtraction signal to said second response amplification stage when outputting a stimulus signals to said stimulus amplifier connected to said recording/STI electrode;
(v) wherein subtraction of said second artifact template from the measured stimulus response signal results in removal of the artifacts from the measured stimulus response signal.

US Pat. No. 10,136,830

NEUROPHYSIOLOGICAL DATA ANALYSIS USING SPATIOTEMPORAL PARCELLATION

Elminda Ltd., Herzliya (...

1. A method of analyzing neurophysiological data recorded from a brain of a subject, the method comprising:recording the neurophysiological data by a plurality of measuring devices respectively placed at a plurality of different locations on the scalp of the subject,
operating a data processor for:
identifying activity-related features in the data;
parceling the data according to said activity-related features to define a plurality of capsules, each representing a spatiotemporal activity region in the brain and corresponding to an extremum of the data and a spatiotemporal neighborhood defined as a spatial region in which said extremum is located and a time-interval during which said extremum occurs, wherein a size of said neighborhood is determined based on a property of said extremum;
storing said capsules in a memory;
comparing at least some of said defined capsules to at least one reference capsule;
estimating a brain function of the subject based on said comparison and;
generating on a display an output indicative of said brain function.

US Pat. No. 10,136,829

SYSTEMS AND METHODS FOR USING ELECTROPHYSIOLOGY PROPERTIES FOR CLASSIFYING ARRHYTHMIA SOURCES

St. Jude Medical, Cardiol...

1. A method for determining electrophysiology properties of tissue, the method comprising:acquiring electrical signal data from a plurality of electrodes of one or more catheters;
determining at least one electrode clique from the plurality of adjacent electrodes, wherein the at least one electrode clique comprises at least three adjacent electrodes;
computing local conduction velocity vectors for the at least one electrode clique;
determining at least one catheter orientation independent indicator from which to classify an arrhythmia source based on one or more of an angular dependence parameter associated with a flow field of the local velocity conduction vectors, an eccentricity parameter reflecting the uniformity of local conduction velocity, and divergence and curl-like sums or closed path integral parameters associated with the local conduction velocity vectors; and
displaying a rhythm classification responsive to catheter movement thereby facilitating identification of types and causes of arrhythmia disorders.

US Pat. No. 10,136,828

MAPPING OF ATRIAL FIBRILLATION

Biosense Webster (Israel)...

13. An apparatus, comprising:a probe having a plurality of electrodes and adapted for insertion into a heart of a living subject; and
a processor configured to receive electrical signals from the electrodes and to perform the acts of:
recording electrograms from the electrodes concurrently at respective locations in the heart, the electrograms comprising readings of the electrodes;
generating an activation map from the readings, the activation map having fixed local activation times and adjustable local activation times for respective electrodes based on respective readings;
delimiting activation time intervals for respective adjustable local activation times;
transforming the activation map into a map of electrical propagation waves, comprising:
segmenting the electrograms into a series of frames at respective times, wherein each frame includes a matrix comprising assignments of the fixed local activation times and the adjustable local activation times to the respective electrodes;
modeling at least a portion of the heart as a mesh having vertices, each vertex corresponding to location of a respective electrode;
selecting a vertex, the vertex having connected conduction velocities of electrical propagation, wherein at least one of the connected conduction velocity has a respective adjustable local activation time and a respective activation time interval; and
determining coherence of the waves at the vertex based on the connected conduction velocities;
maximizing coherence of the waves by adjusting at least one of the adjustable local activation times of the connected conduction velocities to at least one adjusted local activation time within the respective activation time intervals;
reporting the at least one adjusted local activation time;
generating an electroanatomical map with at least one coherent wave based on the at least one adjusted local activation time; and
an ablation power generator connected to the probe for ablating tissue in the heart to modify the electrical propagation waves represented in the electroanatomical map.

US Pat. No. 10,136,827

HAND-HELD VITAL SIGNS MONITOR

SOTERA WIRELESS, INC., S...

1. A hand-held vital signs system, comprising:a housing comprising a microprocessor that is operably connected to a touch screen display on a surface of the housing to provide operation controls for the vital signs system on an icon-driven graphical user interface;
at least two electrodes operably connected to the microprocessor configured to measure an electrical signal which is processed by the microprocessor to provide an ECG waveform; and
a first sensor operably connected to the microprocessor configured to measure a low-frequency waveform comprising frequency components of between 40 Hz and 500 Hz indicative of heart valve operation;
a second sensor operably connected to the microprocessor configured to measure an optical waveform,
wherein the microprocessor is configured to collectively process the low-frequency waveform and the ECG waveform to determine a pre-ejection period, to collectively process the optical waveform, the ECG waveform and the pre-ejection period to determine a vascular transit time, and to determine a blood pressure value using the vascular transit time.

US Pat. No. 10,136,826

SYSTEM AND METHOD FOR DISTINGUISHING A CARDIAC EVENT FROM NOISE IN AN ELECTROCARDIOGRAM (ECG) SIGNAL

ZOLL MEDICAL CORPORATION,...

1. A wearable defibrillator comprising:at least one therapy pad for rendering treatment to a patient wearing the wearable defibrillator;
at least one sensing electrode for obtaining an electrocardiogram (ECG) signal from the patient;
a processing unit comprising at least one processor operatively coupled to the at least one therapy pad and the at least one sensing electrode; and
at least one non-transitory computer-readable medium comprising program instructions that, when executed by the at least one processor, causes the processing unit to:
obtain the ECG signal;
determine a transformed ECG signal based on the ECG signal;
extract at least one value representing at least one feature of the transformed ECG signal;
provide the at least one value to determine a score associated with the ECG signal, thereby providing an ECG-derived score;
compare the ECG-derived score to a predetermined threshold score determined by machine learning; and
provide an indication of a cardiac event based on the comparison of the ECG-derived score with the predetermined threshold score,
wherein the transformed ECG signal comprises a power spectral density (PSD) of the ECG signal, the PSD being determined by calculating a fast Fourier transform (FFT) of the ECG signal, and
wherein at least four features of the PSD are extracted and provided to the machine learning.

US Pat. No. 10,136,825

LONG-TERM IMPLANTABLE SILICON CARBIDE NEURAL INTERFACE DEVICE USING THE ELECTRICAL FIELD EFFECT

University of South Flori...

1. An implantable neural interface device, the device comprising:a control unit;
at least one substantially planar neural probe coupled to the control unit, each of the at least one substantially planar neural probes comprising;
at least one neural tissue stimulation device comprising at least one electrolyte insulator semiconductor capacitor (EISCap) having a cubic silicon carbide (3C—SiC) base and a biocompatible and chemically resistant gate insulator, wherein neural tissue in contact with the electrolyte insulator semiconductor capacitor (EISCap) forms a gate conductor to generate an electric field to stimulate the neural tissue at least partially surrounding the at least one substantially planar neural probe; and
at least one neural tissue stimulation receiving device comprising at least one field effect transistor having a cubic silicon carbide (3C—SiC) base, wherein neural tissue in contact with the at least one field effect transistor forms a gate conductor and wherein the at least one neural tissue stimulation receiving device receives ionic changes generated by the neural tissue resulting from the electric field stimulation by the at least one neural tissue stimulation device.

US Pat. No. 10,136,824

ARTERIAL SPIN LABELING (ASL) WITH MAGNETIC RESONANCE FINGERPRINTING (MRF)

Case Western Reserve Univ...

1. A method for performing arterial spin labeling (ASL) with magnetic resonance fingerprinting (MRF), comprising:selecting an ASL-MRF pulse sequence to apply to an object, where the ASL-MRF pulse sequence includes a labeling pulse and a control pulse;
controlling a magnetic resonance (MR) apparatus to apply the ASL-MRF pulse sequence to the object;
acquiring a nuclear magnetic resonance (NMR) signal evolution from the object, where the NMR signal evolution depends, at least in part, on a property of the arterial spins in the object;
selecting an entry in an MRF dictionary associated with the NMR signal evolution, and
simultaneously quantifying two or more properties of the arterial spins in the object based, at least in part, on the entry.

US Pat. No. 10,136,823

METHODS AND APPARATUS FOR DETERMINING CUFF BLOOD PRESSURE

Board of Trustees of Mich...

1. A method for determining blood pressure for a subject using a sphygmomanometer having a cuff and a pressure sensor integrated therein, comprising:measuring an oscillometric cuff pressure waveform of the subject using the sphygmomanometer, where the oscillometric cuff pressure waveform indicates the time evolution of the pressure inside the cuff during inflation and deflation of the cuff;
measuring volume of air pumped into and out of the cuff during inflation and deflation of the cuff;
determining the cross-sectional area waveform of the artery underneath the cuff using the volume of air pumped into and out of the cuff and the measured oscillometric cuff pressure waveform;
determining an envelope of the cross-sectional area waveform as a function of the measured oscillometric cuff pressure waveform; and
determining, by the computer processor, blood pressure for the subject using the envelope.

US Pat. No. 10,136,822

METHOD AND APPARATUS FOR NON-INVASIVELY DETECTING BLOOD VOLUME IMBALANCES IN A MAMMALIAN SUBJECT

Zynex Monitoring Solution...

1. An apparatus for noninvasively detecting blood volume changes in a mammalian subject, the apparatus comprising: a number of noninvasive sensors, communicable with the subject to obtain baseline and real time (current) physiologic value measurements from the subject; and at least one integrated circuit, operably connected with the sensors and configured to i) compute a real time (current) blood volume index from the physiologic value measurements wherein the blood volume index is derived from at least three physiological parameters selected from the group including heart rate, electrical body impedance, skin temperature, peripheral blood flow and skin humidity and wherein measurements of electrical body impedance, skin temperature, peripheral blood flow and skin humidity are taken at one or more extremities of the subject, and wherein the parameters are monitored by obtaining real time (current) value measurements for the parameters which are inputted into an algorithm which computes the real time (current) blood volume index based upon the differences between the baseline and real time (current) value measurements and wherein the algorithm includes coefficients for accurately weighting each parameter in the real time blood volume index, and wherein said algorithm for computing the real time (current) blood volume index=(100*(1?(((BINormalized?BIBaseline)/BIBaseline)*BICoefficient)?(((HRRealtime?HRBaseline)/HRBaseline*HRCoefficient)+(((PBFRealtime?PBFBaseline)/PBFBaseline*PBFCoefficient)?(((GSRRealtime?GSRBaseline)/GSRBaseline*GSRCoefficient)+(((STempRealtime?STempBaseline)/STempBaseline*STempCoefficient))) wherein BINormalized is peripheral bioimpedance normalized by removing known physiological drift, BICoefficient=0.725, HRCoefficient=0.145, PBFCoefficient=0.043, GSRCoefficient=0.014, and StempCoefficient=0.072, and ii) display the real time (current) blood volume index on a display of the apparatus, wherein the display is initially set to display a starting value blood volume index of 100 which indicates 100% of the subject's normal total blood volume, and wherein the displayed real time (current) blood volume index is capable of indicating a blood volume change in the subject as low as 10% of the subject's total blood volume.

US Pat. No. 10,136,821

IMAGE GENERATING APPARATUS, IMAGE GENERATING METHOD, AND PROGRAM

CANON KABUSHIKI KAISHA, ...

1. An apparatus for generating a photoacoustic image based on an acoustic wave caused by irradiation of light on an object, comprising:a determination unit configured to determine a propagation velocity of the acoustic wave; and
an image generation unit configured to generate the photoacoustic image based on the propagation velocity and a signal obtained by detecting the acoustic wave;
wherein the determination unit is configured to
set, based on an ultrasonic image obtained by transmitting and receiving an ultrasonic wave, a target position, and
determine, based on the signal corresponding to the target position, the propagation velocity.

US Pat. No. 10,136,820

METHOD TO VISUALIZE VERY EARLY STAGE NEOPLASM OR OTHER LESIONS

1. A treatment evaluation method comprisinganalyzing a liquid biopsy sample from a patient for the presence of at least one detectable biomarker of a lesion for which the patient has a family history of predisposition before there is any clinical manifestation or radiographic evidence of the lesion,
generating one or more anti-tumor antibodies based upon the at least one biomarker of the lesion detected in the liquid biopsy sample,
conjugating the one or more anti-tumor antibodies with nanoparticles to form functionalized antibody-coated nanoparticles,
administering, to the patient, the functionalized antibody-coated nanoparticles having a detectable property, the nanoparticles being further coated with a thermosensitive polymer coating,
heating the nanoparticles with an energy source to generate photoacoustic signals,
performing photoacoustic imaging with a photoacoustic imager to visualize any locally accumulated nanoparticles at a body site in the patient,
imaging the lesion at the site so as to determine the location of the lesion in or on the body of the patient by means of the locally accumulated nanoparticles, the lesion being otherwise radiographically undetectable absent the locally accumulated nanoparticles,
where the heating of the nanoparticles with the energy source further comprises heating the nanoparticles from a body temperature of 37° C. to a temperature between 40° C. and 43° C. to melt the thermosensitive polymer coating and release at least one of a medication, a gene together with a CRISPR/cas9 complex, or a checkpoint inhibitor from the nanoparticles,
treating the patient for the lesion by the release of the at least one medication, gene together with the CRISPR/cas9 complex, or checkpoint inhibitor from the nanoparticles locally at the location of the lesion, and
performing the method at least one time post-treatment to evaluate the treatment outcome quantifying the presence or absence of circulating cells or exosomes in the patient.

US Pat. No. 10,136,819

SHORT-WAVE INFRARED SUPER-CONTINUUM LASERS AND SIMILAR LIGHT SOURCES FOR IMAGING APPLICATIONS

Omni Medsci, Inc., Ann A...

1. An imaging device, comprising:a first part of the imaging device comprising a first at least one of a plurality of laser diodes, the first at least one of the plurality of laser diodes configured to be pulsed;
a second part of the imaging device comprising a second at least one of the plurality of laser diodes;
the plurality of laser diodes configured to generate light having one or more optical wavelengths, wherein at least a portion of the one or more optical wavelengths is a near-infrared wavelength between 700 nanometers and 2500 nanometers;
a first one or more lenses configured to receive at least a portion of the light from the plurality of laser diodes and to direct at least the portion of the light to tissue;
an array of laser diodes configured to generate light formed as a plurality of spots, the light having one or more optical wavelengths, wherein at least a portion of the one or more optical wavelengths is a near-infrared wavelength between 700 nanometers and 2500 nanometers;
a second one or more lenses configured to receive at least a portion of the light from the array of laser diodes and to direct at least the portion of the light from the array of laser diodes to tissue;
a first receiver comprising one or more detectors;
the first receiver configured to receive at least a portion of light reflected from the tissue from the first one of the plurality of laser diodes, wherein the first receiver is configured to be synchronized to the at least one of the plurality of pulsed laser diodes and is configured to perform a time-of-flight measurement;
an infrared camera configured to receive at least a portion of light from the second one of the plurality of laser diodes reflected from the tissue;
the infrared camera configured to:
generate a first signal while the plurality of laser diodes and the array of laser diodes are off; and
generate a second signal while the second part of the imaging device is on and the first part of the imaging device and the array of laser diodes are off, the second signal based at least in part on a portion of the light from the second part of the imaging device reflected from the tissue;
wherein the infrared camera is configured to difference the first signal and the second signal to generate a two-dimensional or three-dimensional image;
the imaging device coupled to one of a smart phone, tablet, or computer, the smart phone, tablet, or computer comprising a wireless receiver, a wireless transmitter, a display, a voice input module, and a speaker, the smart phone, tablet, or computer configured to receive and to process at least a portion of the time-of-flight measurement, the two-dimensional or three-dimensional image, and the received light from the plurality of spots reflected from the tissue.

US Pat. No. 10,136,818

HIGH RESOLUTION INTRAOPERATIVE MRI IMAGES

Tel Hashomer Medical Rese...

1. A method of providing an intraoperative magnetic resonance image of a target site of a patient body at which a medical procedure is performed, the method comprising:acquiring a high resolution preoperative magnetic resonance image (MRI), MRIo, of a first region of the patient comprising the target site, the MRIo image comprising a plurality of slices MRIo,n having voxels;
acquiring a preoperative, iMRIo image of a second region of the patient comprising the target site, using an iMRI scanner having a field of view (FOV), the iMRIo image comprising a plurality of slices iMRIo,m having voxels;
registering the MRIo image to the iMRIo image to provide a rigid body transform (iRT0) that transforms image MRIo to image iMRIo;
acquiring an iMRI1 image of the target site during performance of the medical procedure;
registering image iMRIo to image iMRI1 to determine a non-rigid body transform (NRT1); and
applying iRT0 and NRT1 to image MRIo to provide a high resolution (hiQ-iMRI1) image.

US Pat. No. 10,136,816

MEDICAL DEVICES AND METHODS

Abbott Diabetes Care Inc....

1. A system, comprising:an analyte sensor configured to be in fluid contact with bodily fluid under a skin surface;
sensor electronics including a memory, the sensor electronics operatively coupled to the analyte sensor to receive signals generated by the analyte sensor and to log data in the memory corresponding to the received signals generated by the analyte sensor, and further configured to detect a transmitted query; and
a display device configured for data communication with the sensor electronics, the display device comprising:
a storage device having stored therein one or more routines;
a processing unit operatively coupled to the storage device and configured to retrieve the stored one or more routines for execution;
a data transmission component operatively coupled to the processing unit and configured to transmit data based at least in part on the one or more routines executed by the processing unit; and
a data reception component operatively coupled to the processing unit and configured to receive analyte related data from the sensor electronics and to store the received analyte related data in the storage device;
wherein the data transmission component is programmed to transmit a query to the sensor electronics;
wherein the data reception component receives the analyte related data from the sensor electronics in response to the transmitted query when the sensor electronics transitions from a low power state to a fully operational state in response to detection of the query from the data transmission component by the sensor electronics; and
wherein the sensor electronics is configured to overwrite the logged data in the memory prior to an expiration of a life of the analyte sensor with new data corresponding to signals obtained from the analyte sensor after the expiration of the analyte sensor life, the sensor electronics configured to communicate to the data reception component of the display device the analyte related data that includes the logged data in the memory including the new data corresponding to the signals obtained from the analyte sensor after the expiration of the analyte sensor life.

US Pat. No. 10,136,815

PATIENT MONITORING DEVICE WITH REMOTE ALERT

PHYSIO-CONTROL, INC., Re...

1. A patient monitoring system, comprising:a main patient monitor configured to:
receive and collect one or more patient physiological parameters of a patient, and
provide an alarm in response, at least in part, to an alarm trigger, the alarm trigger including a determination that at least one of the collected patient physiological parameters has reached a predetermined value; and
one or more of remote patient monitors, each of the one or more of remote patient monitors having an alarm reset configured to:
terminate the alarm,
be carried by a caregiver,
receive a signal from the main patient monitor in response to the alarm, and
transmit, by the remote patient monitor carried by the caregiver, feedback on the alarm trigger by the caregiver to other caregivers via the main patient monitor, the feedback comprising one or more of a notification that the patient is being attended, a request by the caregiver for additional help, or a message about resolution of the alarm trigger.

US Pat. No. 10,136,814

AUTOMATIC PATHWAY AND WAYPOINT GENERATION AND NAVIGATION METHOD

COVIDIEN LP, Mansfield, ...

1. A method of providing a pathway from a starting point to a target location within a patient, comprising:selecting a target location within a patient;
using a processor to execute instructions stored on a non-transitory computer-readable storage medium to cause the processor to determine a pathway from a starting point to the target location by beginning at the target location and following back to the starting point, wherein determining the pathway includes assigning at least one waypoint along the pathway;
positioning a locatable guide at the starting point; and
advancing the locatable guide from the starting point to the target location following the determined pathway,
wherein determining the pathway further includes:
calculating an airway diameter along a path, as a candidate for the pathway, from the target to the starting point;
detecting a decrease in the airway diameter along the path; and
aborting the path if the decrease in the airway diameter is detected.

US Pat. No. 10,136,813

SYSTEMS AND METHODS FOR PATIENT CARDIOVASCULAR AND RESPIRATORY MANAGEMENT

1. A method for displaying integrated graphics for diagnostics for a patient's physiology, the method comprising:displaying a cardiac graphic object representing cardiac performance based on at least one measurement from the patient's left ventricle performance, said cardiac graphic object including at least a first, second, and third physiological parameter;
displaying at least one dynamic graphical line from the first physiological parameter being displayed to the second physiological parameter being displayed, and wherein the displaying of the dynamic graphical line comprises illustrating at least one functional relationship between the first and second physiological parameters;
displaying a pulmonary graphic object representing pulmonary performance, wherein displaying the pulmonary graphic object comprises displaying pulmonary vascular blood flow, and wherein the displaying the pulmonary vascular blood flow comprises displaying at least one measurement based on the patient's pulmonary arterial blood pressure and at least one measurement based on the patient's pulmonary venous blood pressure, and at least one measurement based on the patient's pulmonary vascular resistance; and
displaying a systemic vascular graphic object representing systemic cardiovascular performance, wherein displaying the systemic vascular graphic object comprises displaying systemic vascular blood flow, wherein the displaying the systemic vascular blood flow comprises displaying at least one measurement based on the patient's systemic arterial blood pressure and at least one measurement based on the patient's systemic venous blood pressure, and at least one measurement based on the patient's systemic vascular resistance.

US Pat. No. 10,136,812

OPTICAL COHERENCE TOMOGRAPHY APPARATUS FOR SELECTIVELY VISUALIZING AND ANALYZING VASCULAR NETWORK OF CHOROIDAL LAYER, AND IMAGE-PROCESSING PROGRAM AND IMAGE-PROCESSING METHOD FOR THE SAME

UNIVERSITY OF TSUKUBA, T...

1. An optical coherence tomography apparatus for selectively visualizing and analyzing a vascular network in a choroidal layer comprising:an optical coherence tomography device, and
a computer that obtains three-dimensional OCT tomographic images based on OCT-measured data acquired by the optical coherence tomography device and processes the three-dimensional OCT tomographic images,
wherein the computer comprises:
a means for acquiring image data of the choroidal vessels by selectively separating out only images of choroidal vessels from the three-dimensional OCT tomographic images, and
a means for obtaining data to be used in a quantitative evaluation of a shape of the choroidal vessels based on the image data of the choroidal vessels;
wherein the means for acquiring image data of the choroidal vessels performs extracting tomographic image data of the choroidal layer from the OCT-measured data, extracting data of image slices from the tomographic image data of the choroidal layer, which data of image slices are image data representing the choroidal layer sliced at equally pitched positions in a depth direction of the choroidal layer, and then acquiring the image data of the choroidal vessels from the data of image slices, and
wherein the means for acquiring image data of the choroidal vessels is constituted in a manner that, for each of multiple windows of different sizes, each pixel in the image slice is binarized according to whether or not a pixel color density is equal to or higher than a pre-determined specified threshold in order to obtain an estimated vessel parts-extracted binary image, and
in this estimated vessel parts-extracted binary image, those regions where a ratio of pixels with different binary data to each pixel in an applicable window is equal to or greater than a pre-determined specified value are deleted as pseudo vessels, while the estimated vessel parts whose diameter is smaller than a pre-determined specified diameter with respect to a dimension of the applicable window are also erased as noise and non-vessels, in order to obtain binary image data of the vascular network in the choroidal layer.

US Pat. No. 10,136,811

FUNDUS IMAGING APPARATUS AND METHOD FOR CONTROLLING THE SAME, AND STORAGE MEDIUM

CANON KABUSHIKI KAISHA, ...

1. A fundus imaging apparatus configured to capture a fundus image of a subject eye, the apparatus comprising:an optical unit configured to guide light from a light source to a fundus;
a wavefront measurement unit configured to measure the wavefront of reflected light guided via the optical unit after the light is reflected on the fundus;
a wavefront correction unit provided on an optical path extending between the light source and the subject eye and configured to correct the wavefront;
an image-capturing unit configured to receive the reflected light and capture an image of the fundus;
an acquisition unit configured to acquire thickness information about an optical diffusive layer of the fundus; and
a determination unit configured to determine a correction value to be used when the wavefront correction unit corrects the wavefront based on the thickness information.

US Pat. No. 10,136,810

SYSTEMS AND METHODS FOR DIAGNOSIS AND THERAPY OF VISION STABILITY DYSFUNCTION

NEUROSCIENCE RESEARCH AUS...

1. A device for obtaining vestibulo-ocular reflex data from a patient having a head and at least one eye, the device including:a frame configured for mounting to the patient;
a target module mounted to the frame and being responsive to a drive signal to project a selectively movable target object onto a surface in front of the patient;
an eye tracking module mounted to the frame, the module being adapted for obtaining first data indicative of one or more characteristics of the at least one eye; and
a head tracking module mounted to the frame, the head tracking module being adapted for obtaining second data indicative of one or more characteristics of the motion of the head.

US Pat. No. 10,136,809

OPHTHALMIC APPARATUS

KABUSHIKI KAISHA TOPCON, ...

1. An ophthalmic apparatus comprising:a refractive power measurement unit configured to project light from a light source onto a subject's eye and detect returning light thereof to determine refractive power of an ocular optical system of the subject's eye; and
an eyeball information measurement unit configured to project light from the light source onto the subject's eye and detect returning light thereof to determine eyeball information representing structure of the subject's eye.

US Pat. No. 10,136,808

OPTICAL COHERENCE TOMOGRAPHY AS A RAPID, ACCURATE, NON-CONTACT METHOD OF VISUALIZING THE PALISADES OF VOGT

1. A method of imaging palisades of Vogt comprising:imaging the palisades of Vogt via a non-contact in-vivo or ex-vivo process to acquire an image, wherein the imaging the palisades of Vogt via a non-contact in-vivo process to acquire the image comprises acquiring high-resolution images rapidly at a predetermined distance from a patient by directing laser light at a corneal limbus of the patient and measuring a delay caused by reflection of the laser light from the corneal limbus, wherein recognition of tissue boundaries depends on contrast between backscattered and/or reflected signal strength;
transferring the image to an analyzing component;
identifying in the analyzing component structures represented in the image to determine a status of the image;
and
storing the image in a data storage component for future evaluation or comparison.

US Pat. No. 10,136,807

OPTICAL COHERENCE TOMOGRAPHY SYSTEM

Canon Kabushiki Kaisha, ...

1. A polarization-sensitive optical coherence tomography system comprising:an interferometer which includes single mode fibers and a plurality of polarization controllers, wherein at least one of the plurality of polarization controllers is disposed on each of the fibers of the interferometer, which include a fiber for a sample light beam, a fiber for a reference light beam, and a fiber for a detection light beam; and
an image forming unit which determines a pixel value from a data set consisting of two orthogonal polarization components simultaneously obtained at substantially identical spatial positions of an object,
wherein a measurement light beam has a static single polarization state.

US Pat. No. 10,136,806

IMAGE DISPLAY METHOD, IMAGE DISPLAY APPARATUS, AND STORAGE MEDIUM

Canon Kabushiki Kaisha, ...

1. An image display method comprising:acquiring a first image of a fundus within a first area of an eye to be inspected;
acquiring interference signal sets corresponding to a plurality of frames, which are acquired with an intention to acquire the same cross section, for a plurality of different cross sections;
generating, based on the interference signal sets corresponding to the plurality of frames, a motion contrast image of the fundus within a second area included in the first area; and
superimposing, for display, information acquired from a portion of the motion contrast image of the fundus onto a corresponding position of the first image of the fundus.

US Pat. No. 10,136,805

APPARATUS, SYSTEM, AND METHOD FOR INTRAOCULAR LENS POWER CALCULATION USING A REGRESSION FORMULA INCORPORATING CORNEAL SPHERICAL ABERRATION

AMO Groningen B.V., Gron...

1. A system for predicting optical power for an intraocular lens, comprising:a first device configured to measure at least one biometric parameter of an eye;
a second device configured to obtain a corneal spherical aberration of the eye according to the at least one biometric parameter;
at least one computing processor configured to apply a modified regression to the at least one biometric parameter and the corneal spherical aberration to output a prediction of an optical power for an intraocular lens to obtain a desired postoperative condition, wherein the modified regression is of the form:
optical power=Regression+constant0*(corneal spherical aberration)
or
optical power=constant1*(biometric parameter)+constant0*(corneal spherical aberration);
wherein constant1 and constant0 comprise an empirically derived factor across other eyes, and wherein Regression comprises a classical regression.

US Pat. No. 10,136,803

RING ILLUMINATED SURGICAL CAMERA

InnovaQuartz LLC, Phoeni...

1. A ring illuminated surgical camera comprising:a ring lens that includes
an emission surface adjacent to a distal end,
a reflector,
an external surface,
a proximal void adjacent to a proximal end, and
an electric wire conduit port passing through the emissions surface and adapted to carry an electronic imaging sensor and imaging sensor electrical contacts; and
a plurality of light emitting diodes (LEDs) carried within the proximal void, adjacent to an internal surface of the ring lens, and adapted to radially emit light.

US Pat. No. 10,136,802

DEVICE FOR SUSTAINED RELEASE OF OPTICAL CLEARING AGENT, ENDOSCOPE HAVING THE SAME, AND INSTRUMENT FOR ENDOSCOPIC SURGERY HAVING THE SAME

OLYMPUS CORPORATION, Tok...

1. A method for achieving sustained release of optical clearing agent comprising:(a) inserting into a lumen a device for sustained release of optical clearing agent without inflating any of at least two pouch-shaped elastic components of the device, the device comprising:
a stick-shaped component inside which at least two supplying passages are formed for supplying gas or liquid and which has apertures of the respective supplying passages formed at positions in a vicinity of a top end of the stick-shaped component along a circumference of a lateral surface thereof,
the at least two pouch-shaped elastic components placed at positions in the vicinity of the top end of the stick-shaped component along the circumference of the lateral surface of the stick-shaped component to cover the respective apertures of the supplying passages respectively;
(b) moving the device for sustained release of optical clearing agent so that the top end of the stick-shaped component, where the pouch-shaped elastic components are provided, is positioned to a diseased region on a wall surface of the lumen;
(c) rotating the stick-shaped component via a rotary unit until a body-fluid absorbing component fixed on a surface of a first pouch-shaped elastic component, which is one of the at least two pouch-shaped elastic components, is made to face the diseased region;
(d) infusing gas or liquid into the first pouch-shaped elastic component from the aperture of a first supplying passage, which is one of the at least two supplying passages inside the stick-shaped component, via the first supplying passage, to inflate the first pouch-shaped elastic component;
(e) pressing the body-fluid absorbing component against the diseased region through deformation of the first pouch-shaped elastic component, to make the body-fluid absorbing component absorb body fluid on a surface of and from inside the diseased region;
(f) discharging the gas or fluid from inside the first pouch-shaped elastic component through the aperture of the first supplying passage, to deflate the first pouch-shaped elastic component and detach the body-fluid absorbing component from the diseased region;
(g) rotating the stick-shaped component via the rotary unit until an optical clearing agent holding component fixed on a surface of a second pouch-shaped elastic component, which is one of the at least two pouch-shaped elastic components, is made to face the diseased region;
(h) infusing gas or liquid into the second pouch-shaped elastic component from the aperture of a second supplying passage, which is one of the at least two supplying passages inside the stick-shaped component, via the second supplying passage, to inflate the second pouch-shaped elastic component; and
(i) pressing the optical clearing agent holding component against the diseased region through deformation of the second pouch-shaped elastic component, to establish sustained release of optical clearing agent held by the optical clearing agent holding component to the diseased region.

US Pat. No. 10,136,801

BENDING PORTION AND ENDOSCOPE

OLYMPUS CORPORATION, Tok...

1. A bending portion in which a plurality of bending pieces are pivotably continuously provided, the bending portion comprising:a first bending piece and a second bending piece provided adjacent to each other;
the first bending piece comprising:
a circular convex portion comprising a peripheral portion having a circular arc shape;
a support portion extended along an axial line direction of the first bending piece from a circular convex portion and supporting the circular convex portion;
a pair of engaging concave portions provided so as to sandwich the circular convex portion and the support portion; and
a pair of distal-end-side contact portions respectively extended from the engaging concave portions in an opposite direction of the circular convex portion,
the pair of engaging concave portions each comprising:
a first inclined portion extended from the support portion in a direction to form an obtuse angle with the support portion;
a second inclined portion extended from the first inclined portion in a direction to form an obtuse angle with the first inclined portion; and
an inside portion that is bent in an obtuse angle with respect to the second inclined portion and extended along a concentric arc of the peripheral portion so as to be adjacent to the distal-end-side contact portion; and
the second bending piece comprising:
a circular concave portion comprising an inside portion having a circular arc shape configured to slide with respect to the peripheral portion, the circular concave portion being provided so as to be pivotable around the circular convex portion;
a pair of engaging convex portions provided so as to sandwich the circular concave portion; and
a pair of proximal-end-side contact portions respectively extended from the engaging convex portions in an opposite direction from the circular concave portion, the pair of proximal-end-side contact portions being configured to come into contact with the distal-end-side contact portions when the circular concave portion pivots around the circular convex portion,
the pair of engaging convex portions each comprising:
 a pair of pointed portions having a shape along the support portion, the first inclined portion, and the second inclined portion, one of the pair of pointed portions being placed at a back of the engaging concave portion to face the support portion, the first inclined portion, and the second inclined portion when the distal-end-side contact portions and the proximal-end-side contact portion contact with each other; and
 an outside portion that is bent in an obtuse angle with respect to the pointed portions and extended along a concentric arc of the inside portion so as to be adjacent to the proximal-end-side contact portion.

US Pat. No. 10,136,800

BENDING OPERATION DEVICE AND ENDOSCOPE

OLYMPUS CORPORATION, Tok...

1. A bending operation device, comprising:a bending lever that is inclinably supported with respect to an operation section of an endoscope;
an arm part that is provided on the bending lever and includes a distal end displaceable in conjunction with inclination operation of the bending lever; and
an intermediate lever, wherein
the intermediate lever includes a fixed end and a free end that are set on both ends in a longitudinal direction of the intermediate lever, the fixed end being swingably supported with respect to the operation section via a fulcrum, the intermediate lever further includes a force point between the fixed end and the free end and a point of application at a position on the intermediate lever that is farther from the fulcrum than the force point and is closer to the free end than the force point, the force point being connected to the distal end of the arm part through an intermediate wire, the point of application being connected to a bending wire, and the bending wire bending a bending portion provided in an insertion section of the endoscope.

US Pat. No. 10,136,799

ENDOSCOPIC SYSTEMS, DEVICES, AND METHODS

Bio-Medical Engineering (...

1. An endoscopic system comprising:an outer assembly, the outer assembly formed as an elongated body and having:
a proximal end;
a distal end;
a first outer pressure cavity provided through the outer assembly between the proximal and distal ends of the outer assembly;
a second outer pressure cavity provided through the outer assembly between the proximal and distal ends of the outer assembly;
a main cavity provided through the outer assembly between the proximal and distal ends of the outer assembly; and
an outer anchor assembly provided at the distal end of the outer assembly, the outer anchor assembly including:
a first expandable member connected to the first outer pressure cavity and configurable to expand radially outwards upon receiving a positive pressure from the first outer pressure cavity; and
a first outer pressure opening connected to the second outer pressure cavity, the first outer pressure opening provided adjacent to the first expandable member, the first outer pressure opening selectively configurable to transition between applying a negative pressure and applying a positive pressure; and
a main assembly, the main assembly formed as an elongated body and having at least a portion of its elongated body housed in the main cavity of the outer assembly, the main assembly having:
a proximal end;
a distal end;
a first main pressure cavity provided through the main assembly between the proximal and distal ends of the main assembly;
a second main pressure cavity provided through the main assembly between the proximal and distal ends of the main assembly;
a plurality of movement cavities provided through the main assembly between the proximal and distal ends of the main assembly in such a way that the plurality of movement cavities are spaced around a center line axis formed by the elongated body of the main assembly;
a navigation section formed at the distal end of the main assembly, the navigation section having:
an instrument;
a second expandable member connected to the first main pressure cavity and configurable to expand radially outwards upon receiving a positive pressure from the first main pressure cavity;
a bendable section having a plurality of subsections, including a most distal subsection at a distal end of the bendable section and a most proximal subsection at a proximal end of the bendable section, the plurality of subsections connected in a linear arrangement, each subsection pivotally moveable relative to an adjacent subsection, each subsection having a plurality of openings provided around its center;
an extendible section having a proximal end and a distal end;
a first main pressure opening connected to the second main pressure cavity, the first main pressure opening selectively configurable to transition between applying a negative pressure and applying a positive pressure, the extendible section configured to extend and contract to change a distance between the proximal end and the distal end of the extendible section and to change a distance between the first main pressure opening and the distal end of the main assembly; and
a plurality of tendon members, each tendon member housed in one of the movement cavities, each tendon member having a length greater than a length of the outer assembly;
wherein each tendon member extends through one of the subsection openings of the most proximal subsection, wherein a distal end of each tendon member is in communication with a location of the most distal subsection that is aligned to the subsection opening of the most proximal subsection that received the tendon member, and wherein at least a distal end of the bendable section is configurable to bend when a force is applied to one of the tendon members.