US Pat. No. 11,110,221

SYSTEM AND METHOD FOR MANAGING ADMINISTRATION OF INSULIN TO A USER


16. A method of managing administration of insulin to a user, the method comprising:providing a system for continuously monitoring the user's glucose level comprising:a glucose monitor for continuously monitoring and determining the user's glucose level;
a user interface device operating a user interface application for displaying representations of user intake items;
a database storing a catalog of input items for display on the user interface application and information with a pre-established relationship between each of a plurality of the intake items and a parameter that is related thereto and usable to determine an appropriate change in insulin delivery based upon consumption by the user of each of the plurality of intake items;
an infusion pump configured to effect a controlled delivery of insulin from a source to the user; and
a programmed processing system operatively associated with the glucose monitor, the user interface device, the database and the infusion pump and programmed with a baseline insulin delivery program for the user based upon continuously determined glucose levels;

the programmed processing system being programmed to automatically make a calculation of insulin to be delivered to the user according to the baseline insulin delivery program or make the calculation of insulin to be delivered to the user according to a modified baseline insulin delivery program generated in response to user input data; and
the programmed processing system being programmed to allow the user to provide an input using the user interface application to selectively identify representations of any of the plurality of intake items as an incident of which the related parameters are communicated from the database for processing by the processing system to modify the baseline delivery program and communicate an input to the infusion pump correlated to the modified baseline insulin delivery program to effect insulin delivery in a manner consistent with the modified baseline insulin delivery program,
whereby as an incident of the user inputting an identification of one or more of the intake items using the user interface application, the system is programmed to automatically effect delivery of insulin to the user according to the modified baseline delivery program, instead of the baseline insulin delivery program, determined by the user's consumption of the one or more of the plurality of intake items based upon the pre-established relationship in the database of the inputted identification of the one or more of the intake items and the parameter.

US Pat. No. 11,110,220

OPERABLE IMPLANT


1. An operable implant adapted to be implanted in the body of a patient, the operable implant comprising an operation device and a body engaging portion, the operation device comprises an electrical motor comprising a static part comprising a plurality of coils and a movable part comprising a plurality of magnets, such that sequential energizing of said coils magnetically propels the magnets and this propels the movable part, wherein the operable implant further comprises a gear system adapted to receive mechanical work having a first force and velocity as input, from the movable part of the electrical motor, and output mechanical work having a if force and velocity, wherein the gear system comprises:an operable element connected to the movable part and configured to be propelled by the movable part,
a first gear having the shape of a hollow cylinder, comprising a first number of teeth, on an outside thereof, and
a second gear having the shape of a hollow cylinder, comprising a greater number of teeth than the first gear, on an inside surface thereof, wherein the operable element is adapted to deflect the first gear, and to maintain the first gear deflected such that the teeth of the first gear are interengaged with the teeth of the second gear in at least two angularly spaced positions interspaced by positions at which the teeth are not interengaged, and wherein the operation of the operable element advances the at least two angularly spaced positions and thereby causes relative rotation between the first gear and the second gear.

US Pat. No. 11,110,219

SYRINGE ASSEMBLY

GUANGDONG HAIOU MEDICAL A...


1. A syringe assembly, comprising:a plunger assembly comprising a plunger rod, a spring, a plunger base, and a plunger plug, the plunger rod having a first end member, a second end member, and a first accommodating room, the first end having a first stepped part positioned in an inner wall thereof, the plunger base comprising a plunger body, a locating member, a plunger member positioned at a distal end of the plunger body, a second stepped part protruding from an outer circumference of the plunger body and adjacent to the plunger member, and a projection protruding from an outer circumference of the plunger body and adjacent to the locating member; wherein the plunger body is partly received in the first accommodating room together with the projection abutting against a top portion of the first end member, and the spring is arranged around the plunger body and located between the first stepped part and the second stepped part, and wherein the plunger plug is mounted to the second end member, and defines a fixing groove;
a syringe body comprising a needle cannula defining a second accommodating room to receiving the plunger assembly, a needle base mounted to the needle cannula and defining a first receiving groove, a fixing valve partly received in the first receiving groove and defining a second receiving groove, and a fixing pole partly received in the second receiving groove and protruding out of the first receiving groove, the fixing pole comprising a first convex portion and a third receiving groove; and
a needle mounted in the third receiving groove;
wherein when the syringe assembly is in an advanced position, the spring is in a compressed state, and the first convex portion abuts against the locating member; when the syringe assembly is in a destroyed position, the spring is in a free state, the fixing pole and the needle retracts into the first accommodating room of the plunger rod, and the plunger member is received in the fixing groove.

US Pat. No. 11,110,218

SURGICAL CARTRIDGE, PUMP AND SURGICAL OPERATING MACHINE

D.O.R.C. Dutch Ophthalmic...


1. A surgical cartridge comprising:an inner plate; and
an outer plate arranged approximately parallel to the inner plate,
wherein between the inner plate and the outer plate flow paths are arranged forming an irrigation flow path for directing fluid towards the surgical site via an irrigation connection and an aspiration flow path for directing fluid away from the surgical site via an aspiration connection,
wherein the inner plate comprises membranes adapted for cooperation with plungers and valves of a membrane pump, and
wherein the membranes comprise a main membrane, at least a first valve and a second valve and an auxiliary membrane adapted to cooperate with a main membrane plunger, valves and an auxiliary membrane plunger of the pump respectively,
wherein the main membrane and the auxiliary membrane are arranged in series along the aspiration flow path, and wherein the auxiliary membrane is arranged between the aspiration connection and the main membrane for compensating movement of the main membrane to provide for an approximately even fluid flow from the surgical site,
wherein the first valve is located between the main membrane and the auxiliary membrane, and wherein the second valve is located downstream from the main membrane in the aspiration flow path.

US Pat. No. 11,110,217

SELF-LOADING FLUID LINE LOOP ARRANGEMENT FOR CENTRIFUGE SYSTEM

Terumo BCT, Inc., Lakewo...


1. A centrifuge assembly, comprising:a centrifuge housing having an outer surface and an internal cavity, wherein the centrifuge housing rotates about a rotation axis of the centrifuge assembly;
a fluid separating body disposed at least partially within the internal cavity of the centrifuge housing and configured to rotate relative to the centrifuge housing about the rotation axis; and
a fluid line loop arm attached to a portion of the centrifuge housing and running along a length of the outer surface of the centrifuge housing, the fluid line loop arm including a bearing set disposed at a point along the length of the outer surface, wherein the bearing set is configured to contact a tubing portion of an interconnected fluid line loop and maintain the fluid line loop in an engaged position relative to the centrifuge housing while allowing the fluid line loop to rotate in the engaged position.

US Pat. No. 11,110,216

SYSTEMS AND METHODS FOR OPTIMIZATION OF PLASMA COLLECTION VOLUMES

Fenwal, Inc., Lake Zuric...


1. A system for collecting plasma comprising:a venipuncture needle for drawing whole blood from a donor;
a blood separator for separating the whole blood into a plasma product and a second blood component comprising red blood cells, the blood separator having a plasma output port connected to a plasma line for sending the plasma product component to a plasma product collection container;
a donor line fluidly connected to the venipuncture needle for introducing the whole blood from the donor to the separator and for returning concentrated red blood cells to the donor, flow through the donor line being controlled by a first pump;
an anticoagulant line connected to an anticoagulant source, the anticoagulant line configured to introduce anticoagulant into the donor line; and
a controller configured to control the operation of the blood component separation device and the first pump, the controller configured to calculate a target donor raw plasma volume (VRP) to be collected prior to an initial draw phase and/or a target plasma product volume (VPP) to be collected based, at least in part, on a weight, height and sex of the donor and a hematocrit (Hct) of the donor and the volume of anticoagulant to be added to the target donor raw plasma volume based on an anticoagulant ratio (ACR) and the hematocrit (Hct) of the donor, wherein the controller is further programmed to determine the target plasma product volume (VPP) based on the target donor raw plasma volume (VRP), the hematocrit (Hct) and an anticoagulant ratio (ACR) such that:VPP=VRP*K, wherein K=(ACR*(1-Hct/100)+1)/(ACR*(1-Hct/100)).


US Pat. No. 11,110,215

DEGASSER AND VENT MANIFOLDS FOR DIALYSIS

Medtronic, Inc., Minneap...


1. A degasser manifold, comprising:a plurality of passageways fluidly connectable to one or more inlets and one or more outlets in a dialysis system;
the one or more inlets comprising a first inlet fluidly connectable to a first fluid line, the first fluid line fluidly connectable to a dialysate flow path, and a second inlet fluidly connectable to a second fluid line; the second fluid line fluidly connectable to an outlet of a degasser;
the one or more outlets comprising a first outlet fluidly connectable to an inlet of the degasser and a second outlet fluidly connectable to a third fluid line, the third fluid line fluidly connectable to the dialysate flow path downstream of the first fluid line.

US Pat. No. 11,110,214

METHODS AND SYSTEMS FOR MEASURING AND HEATING DIALYSATE

Fresenius Medical Care Ho...


1. A dialysate generation system for generating a dialysate fluid external to a dialysis machine, wherein the dialysis machine is configured to receive and use the dialysate fluid to conduct a dialysis treatment session, comprising:a container defined by a plurality of molded plastic walls forming a polygonal housing with a flat external bottom surface, positioned external to the dialysis machine and configured to hold dialysate fluid, wherein the container comprises an internal base surface that, relative to a substantially horizontal surface, has a slope in a range of 0.1 degrees to 50 degrees and an outlet tube and wherein the internal base surface is adapted to directly contact the dialysate fluid and is fixedly coupled to the substantially horizontal surface;
a base enclosure external to the dialysis machine having a flat top surface and configured to detachably receive the bottom surface of the container, wherein the base enclosure comprises:a first scale in physical communication with the bottom surface of the container and configured to weigh the dialysate fluid positioned within the container; and
a conductivity sensor positioned proximate the bottom surface of the container and configured to measure a conductivity of the dialysate fluid in the container;

a fluid pathway connected to the outlet tube and extending from the container to the dialysis machine; and
a heating element positioned external to the base enclosure and configured to heat the dialysate fluid as the dialysate fluid passes through the fluid pathway, wherein the heating element comprises a resistive or an inductive heating element positioned cylindrically along the fluid pathway, longitudinally along the fluid pathway, and in temperature communication with the fluid pathway.

US Pat. No. 11,110,213

MIXING FOR ONLINE MEDICAL FLUID GENERATION

Gambro Lundia AB, Lund (...


1. A dialysis system comprising:a source of water made suitable for a dialysis treatment;
at least one concentrate for mixing with the water from the source;
a dialysis fluid pump; and
a disposable set operable with the dialysis fluid pump and in fluid communication with the source of water and the at least one concentrate, the disposable set including a container having a first proximal end and a second distal end, the container configured such that the water and the at least one concentrate pumped by the dialysis fluid pump enters at the second distal end and exits from the first proximal end, via a passageway extending from the first proximal end to the second distal end, to mix for the dialysis treatment,
wherein the first proximal end includes a connector, the connector defining at least one groove positioned and arranged on an outer surface of the connector,
the at least one groove is configured to allow the water and the at least one concentrate, which are at least partially mixed together, to travel through the at least one groove formed between the connector and the container to a port of the container, and
the connector is associated with at least one one-way valve configured to prevent the water and the at least one concentrate from flowing from an inside of the container and back through the passageway towards the first proximal end.

US Pat. No. 11,110,212

BLOOD CIRCUIT ASSEMBLY FOR A HEMODIALYSIS SYSTEM

DEKA Products Limited Par...


1. A blood circuit assembly for a dialysis unit, comprising:an organizing tray;
a pair of pneumatic pumps and blood flow paths on a blood pump cassette having a pump chamber plate on one surface and an actuation plate on an opposing surface, the cassette mounted to the organizing tray for circulating blood received from a patient through a circuit including a dialyzer unit and returned to the patient, the pneumatic pumps each having a rigid chamber defined by the pump chamber plate and the actuation plate with a flexible diaphragm between the pump chamber plate and the actuation plate dividing the chamber into a pumping compartment and a control compartment, the control compartment including a pneumatic pump control port on the actuation plate arranged for mating with a corresponding pneumatic pump port located on a front panel of the dialysis unit so that pneumatic control can be applied by the dialysis unit to each pneumatic pump via the pneumatic pump control port;
a metering pump on the cassette for delivering medication to one of the blood flow paths of the cassette;
a medication container attachment on the cassette fluidly connected via a port on the pump chamber plate to one or more metering pump flow paths in the cassette for providing a source of medication from a container to the metering pump;
an air vent on the blood pump cassette fluidly connected to the one or more metering pump fluid paths for providing a source of air to the container as fluid is drawn by the metering pump from the container;
a plurality of pneumatic valves in the metering pump flow paths for sequential delivery of medication from the medication container to the metering pump, and from the metering pump to the one or more blood flow paths of the blood pump cassette, and for periodic air injection from the air vent through the metering pump to the container, said pneumatic valves having pneumatic valve control ports arranged for mating with corresponding pneumatic valve ports located on the front panel of the dialysis unit;an air trap mounted to the organizing tray arranged to remove air from blood circulating in the circuit;
a pair of dialyzer connections arranged to connect to an inlet and outlet of a dialyzer unit; and
a pair of blood line connectors, one inlet blood line connector for receiving blood from the patient and providing blood to the pneumatic pumps and the other outlet blood line connector for returning blood to the patient,

wherein the pneumatic pump control ports of the pneumatic pumps and the pneumatic valve control ports of the pneumatic valves may be mounted to the front panel of the dialysis unit by being pushed into place onto the corresponding pneumatic ports on the front panel of the dialysis unit, and may be disengaged by pulling the pneumatic pumps from the pneumatic ports of the dialysis unit.

US Pat. No. 11,110,211

PLATELET SEPARATOR, PLATELET RECOVERY DEVICE, PLATELET COLLECTION SYSTEM, AND PLATELET COLLECTION METHOD

Terumo Kabushiki Kaisha, ...


1. A disposable platelet recovery set comprising:a primary separation unit adapted to be mounted on a rotor of a centrifuge, said primary separation unit comprising a flexible container having an inlet that accommodates whole blood collected from a donor to centrifuge the whole blood into at least a first blood component comprising platelets and a remaining fluid and at least one outlet;
a secondary separation unit adapted to be mounted on said rotor, said secondary separation unit comprising a rigid conical chamber for capturing white blood cells and having an inlet that accommodates the first blood component transferred from said outlet of the primary separation unit to centrifuge the first blood component into a platelet containing component and a white blood cell containing component and having an outlet; and
a tertiary separation unit adapted to be mounted on said rotor that centrifuges the platelet containing component transferred from the secondary separation unit, wherein the tertiary separation unit comprises
a chamber comprising
a ceiling,
a flexible bottom portion,
a first side wall connecting said ceiling and said flexible bottom portion, thereby forming a first region for receiving platelets and fluids,
a second bottom portion spaced away from said first bottom portion,
a second side wall, said second side wall connecting said ceiling to said second bottom portion, forming a second region in fluid communication with said first region,
a step wall between said flexible bottom portion and said second bottom portion,
at least one inlet port in said ceiling in fluid communication with said first region and an outlet port in said ceiling in fluid communication with said second region.

US Pat. No. 11,110,210

SELF-EXPANDING DEVICES AND METHODS THEREFOR

Intersect ENT, Inc., Men...


1. A method of treating one or more sinus conditions in a patient, the method comprising:dilating a paranasal sinus region with an expandable balloon, wherein an expandable device is detachably coupled around the expandable balloon;
delivering the expandable device to the dilated paranasal sinus region, wherein the expandable device disengages from the expandable balloon, wherein the expandable device is configured to expand from a first compressed configuration to a second expanded configuration for conformation against sinus tissue, and wherein the expandable device is at least partially coated with a drug eluting layer comprising a drug, the drug eluting layer configured to release the drug at a daily dosage of about 500 ?g or less per day; and
withdrawing the expandable balloon from the paranasal sinus region after dilation.

US Pat. No. 11,110,209

INTRALUMINAL THERAPY SYSTEM FOR GASTROINTESTINAL INFECTIONS

MACKAY MEDICAL FOUNDATION...


1. A method for treating a gastrointestinal infection in a subject, comprising the following steps:(i) providing a system for dispensing one or more agents to a subject's gastrointestinal tract;
wherein the system comprises:an endoscope apparatus comprising:a light guide device;
an operation section connected to the light guide device;
an insertion tube connected to the operation section;
a bending section connected to the insertion tube; and
a working channel formed within the operation section, the insertion tube and the bending section;

wherein said working channel has an opening formed at the operation section and another opening formed at an end of the bending section; and
an agent dispenser, comprising:a pump for pumping an agent;
a catheter, wherein one end of the catheter connects to the pump so that the catheter could be used for delivering the agent pumped from the pump; and
a nozzle connected to the other end of the catheter;
wherein said catheter extends into the working channel via the opening formed at the operation section and passes through the working channel, then extends outward from the working channel via the opening formed at the end of the bending section;


(ii) administering first antibiotic and/or antimicrobial agent or an antibiotic and/or antimicrobial complex to a gastrointestinal tract using the medical devices, including the endoscope apparatus of the system;wherein the antibiotic and/or antimicrobial complex comprises a second antibiotic or antimicrobial agent linked to a polymer or mixed with any solution which has high affinity to the gastric mucosal surface; and
wherein the antibiotic or antimicrobial complex has a viscosity of 3 to 10,000 cp.


US Pat. No. 11,110,208

IMPLANT, PREFERABLY FOR THE TREATMENT OF AN ACETABULAR DEFECT

AESCULAP AG, Tuttlingen ...


1. An implant for use in treating an acetabular defect, having at least one flat structure which contains a material that is at least partially decomposable or resorbable in vivo, wherein the implant has two flat structures, wherein each flat structure has a central area and three elongated functional areas that extend out from the central area, and wherein the flat structures are arranged one above the other in such a way that the elongated functional areas of one of the two flat structures are arranged offset to the elongated functional areas of the other of the two flat structures.

US Pat. No. 11,110,207

NERVE REPAIR SCAFFOLDS HAVING HIGH MICROCHANNEL VOLUME AND METHODS FOR MAKING THE SAME

THE REGENTS OF THE UNIVER...


1. A tissue scaffold for neural tissue growth comprising:a sheath; and
a plurality of microchannels disposed within the sheath, wherein each microchannel of the plurality comprises (i) a biocompatible and biodegradable material comprising a polyester polymer, and (ii) a porous wall comprising a plurality of pores haying an average pore size of greater than or equal to about 10 m to less than or equal to about 50 m, wherein the porous wall has a thickness of greater than or equal to about 10 m to less than or equal to about 100 m and is free line-of-sight porosity to prevent or minimize cellular growth through the porous wall.

US Pat. No. 11,110,202

CONSTRUCTION AND APPLICATION OF DIFFERENTIALLY REGULATED TISSUE-ENGINEERED NERVE GRAFTS

NANTONG UNIVERSITY, Jian...


1. A differential tissue-engineered nerve, wherein it comprises motor-like nerves and sensory-like nerves, the motor-like nerve comprises a motor-like nerve outer tube and a motor-like nerve fiber in the outer tube, Schwann cells and/or fibroblasts derived from motor nerves are contained in surface or pores of the motor-like nerve outer tube and a transsynaptic signal molecule Neuroligin-1 is contained in surface or pores of the motor-like nerve fiber; andthe sensory-like nerve comprises a sensory-like nerve outer tube and a sensory-like nerve fiber in the outer tube, Schwann cells and/or fibroblasts derived from sensory nerves are contained in surface or pores of the sensory-like nerve outer tube and a transsynaptic signal molecule Neuroligin-2 is contained in surface or pores of the sensory-like nerve fiber.

US Pat. No. 11,110,201

DEVICES INCLUDING MUSCLE MATRIX AND METHODS OF PRODUCTION AND USE

LifeCell Corporation, Ma...


1. A tissue composition comprising:a first muscle matrix layer and a second muscle matrix layer;
a supporting layer comprising a synthetic substrate having a first side and a second side opposite the first side; and
a first binding layer and a second binding layer, the binding layers comprising particulate acellular tissue matrix (ATM) that has been treated with a transglutaminase to attach the muscle matrix layers to the supporting layer, the first binding layer disposed adjacent to the first side of the supporting layer and adjacent to the first muscle matrix layer, the second binding layer disposed adjacent to the second side of the supporting layer and adjacent to the second muscle matrix layer.

US Pat. No. 11,110,200

IONIC POLYMER COMPOSITIONS

Hyalex Orthopaedics, Inc....


1. A packaged article comprising an orthopedic implant and a divalent-cation-containing solution contained within a sterile package, wherein the orthopedic implant comprises an interpenetrating polymer network (IPN) or semi-IPN that comprises a first polymeric network comprising a hydrophobic thermoset or thermoplastic polymer and a second polymeric network comprising a polymer comprising carboxylic acid groups that are underivatized or sulfonic-acid-derivatized, and the divalent-cation-containing solution comprises 0.1 to 5 mM divalent metal cations comprising Ca2+.

US Pat. No. 11,110,199

METHODS FOR HOST CELL HOMING AND DENTAL PULP REGENERATION

THE TRUSTEES OF COLUMBIA ...


1. A hydrogel-based scaffold for dental pulp formation, said scaffold comprisinga biosynthetic hydrogel of polymer, fibrinogen, and 1.0-2.0% v/v of PEG-diacrylate,
wherein fibrinogen is present in the hydrogel-based scaffold at a concentration of 0.5-1.0% w/v for promoting pulp cell growth and biosynthesis, regulating pulp cell migration and morphology, or both.

US Pat. No. 11,110,198

POLYMER PARTICLES

Terumo Corporation, Toky...


1. An embolic composition including:polymer particles comprising at least one monomer including at least one functional group, at least one crosslinker having a structure




at least one pharmaceutical agent.

US Pat. No. 11,110,197

SURGICAL SUTURE MATERIALS WITH POROUS SHEATHS FOR DRUG DELIVERY

Georgia Tech Research Cor...


1. A surgical suture material comprising;an elongated outer sheath having an outer surface, an inner surface that defines a lumen, a plurality of pores extending between the lumen and the outer surface, and an amide-containing polymer material, the amide-containing polymer material comprising carbonyl oxygen atoms bonded to calcium ions throughout the cross-section of the outer sheath, and wherein the plurality of pores are generated from swelling the amide-containing polymer material in a swelling solution comprising calcium ions followed by freeze-drying,
a plurality of elongated filaments located within the lumen of the elongated outer sheath, and
a releasable component located in the lumen and able to move from the lumen through one or more pores of the plurality of pores for release from the suture material,
wherein the elongated outer sheath has a thickness of from about 6 to about 12 micrometers and the lumen has a diameter of greater than 100 micrometers, and
wherein the plurality of pores exhibit pore sizes in the range of 0.5 to 5 micrometers.

US Pat. No. 11,110,194

AROMA CANDLE LAMP WITH 3D SWINGING FLAME

Shenzhen Lycas Electronic...


1. An aroma candle lamp with a 3D swinging flame, comprising:a housing comprising a housing body and a base, the housing body and the base surrounding a hollow cavity, wherein an electronic module and an aroma module are arranged in the hollow cavity, and the electronic candle module is arranged above the aroma module;
the electronic candle module comprising a simulating flame comprising a flame body and a light source that is arranged in the flame body, a fixture for fixing the simulating flame, and a swing device for driving the simulating flame to swing, wherein the fixture comprises a left cover and a right cover, the right cover comprising an inside wall with a light source fixing bracket fixed to the inside wall and with the light source installed on the light source fixing bracket, wherein the swing device comprises a swing bracket and a support block with a support portion and a fixing portion connected to one side of the support portion, wherein the fixing portion is directly fixed on an inside wall of the left cover, wherein the swing bracket rests on the support portion; and
the aroma module comprising an aroma component housing and an aroma bottom cover surrounding an aroma component cavity; an aroma component arranged in the aroma component cavity; an aroma through-hole formed in the aroma component housing above the aroma component cavity; and an aroma fan, wherein the aroma fan is arranged in the aroma through-hole and the aroma fan is configured to rotate to drive aroma to spread out from the aroma candle lamp.

US Pat. No. 11,110,193

AROMA DIFFUSING DEVICE AND METHOD OF CONTROLLING AROMA DIFFUSING DEVICE

SONY CORPORATION, Tokyo ...


1. An aroma diffusing device comprising:a perfume holding part in which a perfume is held;
an air blowing source configured to supply air to the perfume holding part;
an aroma discharge part through which the air having passed through the perfume holding part is discharged;
an operation input part; and
an air blowing source control part configured to control a supply state of the air, wherein the supply state of the air is controlled based on an operation input for the air blowing source performed on the operation input part by a user and a supply time of the air is varied based on an interval at which the operation input is performed by the user.

US Pat. No. 11,110,192

ORAL DEVICE CONTAINER AND ORAL DEVICE SANITATION SYSTEM

Custom Club, Inc., Scott...


1. An oral sanitation system, comprising:a case including:a support portion defining a lower end of the case; and
a container portion extending from the support portion, the container portion defining a wall extending from the support portion to a top end of the container portion;

a closure including a lid formed with a peripherally-extending wall;
a lower cavity defined by the wall of the container portion;
an upper cavity defined by the peripherally-extending wall of the closure; and
a light-guiding floor that is substantially transparent to UVC light, the light-guiding floor forming a bottom of the container portion that is surrounded by the wall.

US Pat. No. 11,110,191

METHOD AND SYSTEM FOR MONITORING ACTIVITY OF AN INDIVIDUAL


1. A monitoring system, comprising:a range detection system configured for scanning a scene to provide range data arranged gridwise over a plurality of picture elements which are devoid of any color data and any grayscale data, said range data including data describing range to a marker that is detectable by said range detection system and that is placed on a hand of an individual in said scene; and
a data processing system configured for processing said range data to identify said marker, to identify said hand based, at least in part on said range to said marker, to identify points of contact between said individual and objects in said scene, and to monitor hygienic activity of an individual in said scene.

US Pat. No. 11,110,190

CURRENCY BILL DISPENSER WITH RADIATION STERILIZATION


1. A disinfecting currency bill dispenser comprising:an enclosure having an inlet and an outlet for currency bill; and
a disinfection chamber having an upper plate and a lower plate separated by spacers, wherein midportion of the upper plate and the lower plate forms a kill passage through which the currency bill passes through, the midportion of each the upper plate and the lower plate having a plurality of concave arc shape cavities arranged lengthwise and side-by-side to form reflective area, the reflective area configured to focus reflected radiations on the currency bill sandwiched between the midportions of the upper plate and the lower plate, each the upper plate and the lower plate comprises a plurality of radiation source configured to irradiate the midportions of the upper plate and the lower plate.

US Pat. No. 11,110,189

DISINFECTING DEVICE

Hydro LLC, Auburn, AL (U...


1. A device comprising:a liquid exchange portion comprising:a first thermal reservoir,
a liquid circulation channel configured to connect the first thermal reservoir to a second thermal reservoir, and
a liquid pumping device configured to circulate liquid, via the liquid circulation channel, between the first thermal reservoir and the second thermal reservoir; and

a disinfecting portion configured to disinfect a surface, the disinfecting portion comprising:a light emitting diode (LED),
a heat sink connecting the LED to the second thermal reservoir,
an insulating layer arranged on the second thermal reservoir, the insulating layer including an orifice arranged over the LED such that light from the LED passes through the orifice of the insulating layer, and
a front layer arranged on the insulating layer and over the orifice.


US Pat. No. 11,110,188

ELECTRON BEAM IRRADIATION DEVICE

HAMAMATSU PHOTONICS K.K.,...


1. An electron beam irradiation device comprising:an electron gun configured to emit an electron beam;
a housing configured to have a main body portion housing the electron gun and a rod portion having a proximal end side connected to the main body portion and a distal end side protruding from the main body portion; and
an electron beam emission window provided on the distal end side of the rod portion,
wherein the rod portion includes:
a first tubular member having a tubular shape with an extending direction of the rod portion as an axial direction, is provided with the electron beam emission window at an end portion on the distal end side, and has an inside through which the electron beam passes;
a second tubular member having a tubular shape with the extending direction of the rod portion as an axial direction and surrounds the first tubular member;
a cooling gas flow space for a cooling gas introduced from the proximal end side to flow to the distal end side, and including at least a cooling gas flow path provided between an outer wall surface of the first tubular member and an inner wall surface of the second tubular member; and
a wall member provided so as to perform partition between an electron beam emission space facing an electron beam emission side of the electron beam emission window and the cooling gas flow space,
the wall member is provided with a cooling gas ejection hole that ejects the cooling gas from the cooling gas flow space to the electron beam emission space, and
the cooling gas ejection hole has a flow path sectional area smaller than a flow path sectional area of the cooling gas flow path.

US Pat. No. 11,110,187

MOBILE STERILIZATION APPARATUS AND METHOD FOR USING THE SAME

Progressive Sterilization...


1. A system for transporting a plurality of medical items between a sterilizer to an operating room or storage room, the system comprising:a cart comprising a plurality of wheels, the cart having a first space for receiving one or more of the plurality of medical items;
a sterilization cabinet received on a second space of the cart, the sterilization cabinet comprising an interior sterilization chamber configured to receive one or more additional medical items of the plurality of medical items, the sterilization cabinet is configured to be opened for insertion and removal of the one or more additional medical items into the interior sterilization chamber, where the sterilization cabinet is configured with at least one vent to permit the sterilizer to sterilize the interior sterilization chamber and the one or more additional medical items;
where an entirety of a floor of the interior sterilization chamber is continuous and is pitched to a lowest point to allow gravity to direct a condensate generated by a steam towards the lowest point, the lowest point being adjacent to an opening in the interior sterilization chamber;
a filter door having a plurality of perforations, the filter door configured to retain a filter in the opening such that gravity directs the condensate from the floor to the filter; and
where the cart is configured to be moved into the sterilizer.

US Pat. No. 11,110,186

ANIONIC CHELATE COMPOUNDS

GENERAL ELECTRIC COMPANY,...


1. A compound of Formula I or a salt or solvate thereof:



wherein:
n is an integer of 1 to 4
R1 is C1-3 alkyl or —(CH2)n+1—C(?O)—NR2R3;
each X is —C(?O)—NR2R3 or —NH—C(?O)—R3;
each R2 is hydrogen, C1-4 alkyl or an anionic substituent;
each R3 is an anionic substituent optionally linked via a C1-4 alkylene; and,
R4 is independently selected from the group comprising hydroxy, halo, amino, amido, C1-6 alkyl and C1-6 hydroxyalkyl and m is between 0-3, wherein each anionic substituent is independently selected from phosphate, phosphonate, hydroxycarboxylate, tetrazole, thiazolidindione, nitromethylsulfonylphenyl, 4-nitrothiophenol, nitromethylcarboxyphenyl, 2,4-dinitrophenol, or malonitrile.

US Pat. No. 11,110,184

METHODS FOR TREATING AND DIAGNOSING BLINDING EYE DISEASES

Translatum Medicus Inc., ...


1. A method for modulating polarization of macrophages associated with a retinal pigment epithelium (RPE) cell layer in the eye of a subject in need thereof, comprising administering to said subject an effective amount of a compound of Formula I:



or a pharmaceutically acceptable salt thereof, wherein:
each of R1 and R2 is independently H or a C1-C6 alkyl and
R3 is H or a C1-C6 alkyl;
wherein the macrophage polarization is M1 and M2 or between M1 and M2, and the macrophages are Iba1+.

US Pat. No. 11,110,181

VIRUS-LIKE PARTICLE CONJUGATES FOR DIAGNOSIS AND TREATMENT OF TUMORS

Aura Biosciences, Inc., ...


1. A tumor-targeting virus-like particle comprising papilloma virus capsid proteins and 50 to 1000 photosensitive molecules conjugated to the capsid proteins, wherein the photosensitive molecules comprise (a) a photosensitive molecule that becomes toxic or produces a toxic molecule upon activation by light and (b) a photosensitive molecule that does not become toxic or produce a toxic molecule upon activation by light.

US Pat. No. 11,110,180

NUCLEIC ACID-POLYPEPTIDE COMPOSITIONS AND USES THEREOF

AVIDITY BIOSCIENCES INC.,...


1. A polynucleotide conjugate molecule comprising a binding moiety and a polynucleotide,wherein the polynucleotide comprises at least one 5?-vinylphosphonate modified non-natural nucleotide and at least one modified internucleotide linkage, or at least one inverted abasic moiety; and
wherein the at least one 5?-vinylphosphonate modified non-natural nucleotide is:




wherein B is a heterocyclic base moiety;
R6 is selected from hydrogen, halogen, alkyl, alkoxy or aminoalkyl; and
J is an internucleotide linking group linking to an adjacent nucleotide of the polynucleotide.

US Pat. No. 11,110,178

ANTIBODY ADJUVANT CONJUGATES

The Board of Trustees of ...


1. An immunoconjugate comprising(a) an antibody construct comprising (i) an antigen binding domain and (ii) an Fc domain,
(b) an adjuvant moiety of formula:





wherein each J independently is hydrogen, OR4, or R4, each R4 independently is hydrogen, or an alkyl, heteroalkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, arylalkyl, or heteroarylalkyl group comprising from 1 to 8 carbons, each U independently is CH or N wherein at least one U is N, each subscript t independently is an integer from 1 to 3, Q is optionally present and is an alkyl, heteroalkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, arylalkyl, or heteroarylalkyl group comprising from 1 to 8 carbons, and the dashed line (“”) represents the point of attachment of the adjuvant, and(c) a linker,

wherein the adjuvant moiety is covalently bonded to the antibody construct via the linker.

US Pat. No. 11,110,177

ASH1L DEGRADERS AND METHODS OF TREATMENT THEREWITH

The Regents of the Univer...


1. A compound having a structure of:









wherein R1 is selected from H, alkyl, substituted alkyl, halogen substituted alkyl, branched alkyl, a substituted brached alkyl halogen substituted branched alkyl, alkoxy, amine, substituted amine, thioalkyl, ketone, amide, a substituted amide, cyano, sulfonyl, carboxy, dialkylphosphine oxide, a carbocyclic ring, a substituted carbocyclic ring, an aromatic ring, a substituted aromatic ring, a heterocyclic aromatic ring, a substituted heterocyclic aromatic ring, a substituted or non-substituted heterocyclic non-aromatic ring carbocyclic or heterocyclic aromatic ring fused to another aromatic ring, a hydrogen bond donor, a hydrogen bond acceptor, and combinations thereof;
wherein R2, R3, R4, R5, and R7, when present, are independently selected from H, halogen, CH3, OH, SH, NH2, CN, CF3, CCl3, —CH2—CH3, —CH2—OH, —CH2NH2, CH3SH, CH2Cl, CH2Br, CH2F, CHF2, CH2CN, CH2CF3, CH2Cl3, alkyl, haloalkyl, and alcohol; and
wherein R6 is selected from H, alkyl, substituted alkyl, halogen substituted alkyl, branched alkyl, a substituted brached alkyl halogen substituted branched alkyl hydroxy, alkoxy, amine, substituted amine, alkylamine, substituted alkylamine, thioalkyl, alkylthioalkyl, halogen, ketone, amide, a substituted amide, alkylamide, substituted alkylamide, cyano, sulfonyl, carboxy, dialkylphosphine oxide, a carbocyclic ring, substituted carbocyclic ring, an aromatic ring, a substituted aromatic ring, a heterocyclic aromatic ring, a substituted heterocyclic aromatic ring, a substituted or non-substituted heterocyclic non-aromatic ring, carbocyclic or heterocyclic aromatic ring fused to another aromatic ring, a hydrogen bond donor, a hydrogen bond acceptor, and combinations thereof;
wherein X is CH or N;
wherein Z is O or S;
wherein A is a covalent bond or is selected from





wherein one of X and Y is




or




and the other is H,




wherein X and Y are independently CH or N,




wherein erein X and Y are O, NH, or CH2, and




wherein X and Y are independently N or CH, and wherein Z is O, NH, or CH2;wherein n, when present, is 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15; wherein m, when present, is 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14 or 15 or ranges therebetween; wherein the Linker is selected from:





















wherein X, Y, and Z groups, when present are independently O, NH, or CH2, and do not need to be the same group when present in the same linker;
wherein n, when present, is 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15;
wherein m, when present, is 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14 or 15 or ranges therebetween;
wherein k, when present is 0, 1, 2, 3, 4, 5, 6, 7, 8, 9 or 10;
wherein l, when present is 0, 1, 2, 3, 4, 5, 6, 7, 8, 9 or 10; wherein the Ligase Ligand is selected from:



or a salt thereof.

US Pat. No. 11,110,175

COMPOSITIONS WITH PERMEATION ENHANCERS FOR DRUG DELIVERY

Massachusetts Institute o...


1. A composition comprising:(a) an antibiotic or a combination of antibiotics, wherein each antibiotic is a ?-lactamase inhibitor or has a molecular weight of about 290 g/mol to about 749 g/mol;
(b) a permeation enhancer or a combination of permeation enhancers selected from the group consisting of limonene, cymene, pinene, camphor, menthol, comphone, phellandrine, sabinene, terpinene, borneol, cineole, geraniol, linalol, pipertone, terpineol, eugenol, eugenol acetate, safrole, benzyl benzoate, humulene, beta-caryophylene, eucakytol, hexanoic acid, octanoic acid, decanoic acid, undecanoic acid, dodecanoic acid, tridecanoic acid, myristic acid, palmitic acid, stearic acid, oleic acid, linoleic acid, linolenic acid, cholic acid; ethyl undecanoate, methyl laurate, methyl myristate, isopropyl myristate, isopropyl palmitate, palmityl palmitate, diethyl sebaccate, glyceryl monolaurate, glyceryl monooleate, and ethylpiperazine carboxylate; and a permeation enhancer with a molecular weight of about 232 g/mol to about 1310 g/mol; wherein the permeation enhancer or combination of permeation enhancers increases the flux of the therapeutic agent or combination of therapeutic agents across a barrier; and
(c) a matrix forming agent or a combination of matrix forming agents, wherein the matrix forming agent or combination of matrix forming agents comprises a polymer;

wherein:the composition forms a gel at temperatures above a phase transition temperature; and
the phase transition temperature is less than about 37° C.;

and at least one of conditions (i), (ii), and (iii) are met:(i) the phase transition temperature of the composition is less than the phase transition temperature of a reference composition plus about 5° C.;
(ii) the storage modulus of the composition is greater than about 15% of the storage modulus of the reference composition or greater than about 500 Pa, whichever is smaller, at a temperature of about 37° C.; and
(iii) the loss modulus of the composition is between about 15% and about 150% of the loss modulus of the reference composition at a temperature of about 37° C.;

wherein the reference composition is the composition in the absence of the permeation enhancer or combination of permeation enhancers;
wherein the polymer comprises a polymer of Formula (I?):




wherein:each occurrence of Y is independently —R1 or -L2R2;
each occurrence of R is independently hydrogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted aryl, or optionally substituted heteroaryl;
each occurrence of L2 is independently a bond, optionally substituted alkylene, optionally substituted alkenylene, optionally substituted alkynylene, optionally substituted heteroalkylene, optionally substituted heteroalkenylene, or optionally substituted heteroalkynylene;
each occurrence of R2 is independently optionally substituted acyl, optionally substituted carbocyclyl, optionally substituted heterocyclyl, optionally substituted aryl, optionally substituted heteroaryl, —ORb, —N(Rb)2, or an oxygen protecting group;
each occurrence of R3 is independently hydrogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted aryl, optionally substituted heteryaryl, optionally substituted acyl, —ORb, or —N(R)2;
each occurrence of Rb is independently optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted carbocyclyl, optionally substituted heterocyclyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted acyl, an oxygen protecting group, or a nitrogen protecting group, or two Rb taken together with the nitrogen to which they are attached form an optionally substituted heterocyclic ring or optionally substituted heteroaryl ring;
each of G1A and G2A is independently hydrogen, halogen, optionally substituted amine, optionally substituted alkyl, optionally substituted aryl, or optionally substituted heteroaryl, optionally substituted acyl, optionally substituted phosphate, or an oxygen protecting group; and
each of p, q, r, s, and t is independently an integer between 1 and 200, inclusive, wherein the sum of p and t is at least 1, and the sum of q, r, and s is at least 1.

US Pat. No. 11,110,174

CARBOHYDRATE CONJUGATES AS DELIVERY AGENTS FOR OLIGONUCLEOTIDES

ALNYLAM PHARMACEUTICALS, ...


1. A ligand-containing conjugate having the structure shown in formula (I):



wherein:
A and B are each independently for each occurrence O, N(RN), or S;
one of X and Y is a solid support, optionally linked via a linker group, or a phosphoramidite, and the other of X and Y is a protecting group;
R is L1 or has the structure shown in formula (II)-(V)




q2A, q2B, q3A, q3B, q4A, q4B, q5A, q5B and q5C represent independently for each occurrence 0-20 and wherein the repeating unit can be the same or different;
Q is absent, -(P7-Q7-R7)p-T7- , or -T7-Q7-TT-B?-T8?-Q8-T8-;
P2A, P2B, P3A, P3B, P4A, P4B, P5A, P5B, P5C, P7, T2A, T2B, T3A, T3B, T4A, T4B, T5A, T5B, T5C, T7, T7?, T8 and T8? are each independently for each occurrence absent, CO, NH, O, S, OC(O), C(O)O, NHC(O), C(O)NH, CH2, CH2NH, NHCH2, OCH2 or CH2O;
B? is —CH2—N(BL)—CH2—;
BL is -TB-QB-TB?-Rx;
Q2A, Q2B, Q3A, Q3B, Q4A, Q4B, Q5A, Q5B, Q5C, Q7, Q8 and QB are independently for each occurrence absent, alkylene, substituted alkylene and wherein one or more methylenes can be interrupted or terminated by one or more of O, S, S(O), SO2, N(RN), C(R?)?C(R?), C?C or C(O);
TB and TB? are each independently for each occurrence absent, CO, NH, O, S, OC(O), C(O)O, NHC(O), C(O)NH, NHC(O)NH, NHC(O)O, OC(O)NH, CH2, CH2NH, NHCH2, OCH2, or CH2O;
Rx is a lipophile, or a cationic lipid;
R2A, R2B, R3A, R3B, R4A, R4B, R5A, R5B, R5c, and R7 are each independently for each occurrence absent, NH, O, S, CH2, C(O)O, OC(O), C(O)NH, NHC(O), NHCH(Ra)C(O), C(O)—CH(Ra)—NH, CO, CH?N—O





or heterocyclyl;L1, L2A, L2B, L3A, L3B, L4A, L4B, L5A, L5B and L5C are each independently for each occurrence a carbohydrate or a derivative thereof having hydroxyl protecting group(s);
R? and R? are each independently H, C1-C6 alkyl, OH, SH, or N(RN)2;
RN is independently for each occurrence methyl, ethyl, propyl, isopropyl, butyl or benzyl;
Ra is H or amino acid side chain; and
p represents independently for each occurrence 0-20.

US Pat. No. 11,110,169

COMPOSITIONS OF VACCINES AND ADJUVANTS AND METHODS FOR THE TREATMENT OF URINARY TRACT INFECTIONS

Sequoia Vaccines, Inc., ...


1. A vaccine composition comprising (i) an effective amount of an antigen of FimCH or truncated FimH, (ii) phosphatidylcholine, and (iii) an adjuvant formulation containing one or more of the following compounds:








or mixtures thereof, or pharmaceutically acceptable salts thereof.

US Pat. No. 11,110,160

GLYCOCONJUGATION PROCESSES AND COMPOSITIONS

Pfizer Inc., New York, N...


1. A glycoconjugate comprising a Streptococcus pneumoniae-derived capsular polysaccharide conjugated to a carrier protein through a (2-((2-oxoethyl)thio)ethyl)carbamate (eTEC) spacer, wherein the polysaccharide is covalently linked to the eTEC spacer through a carbamate linkage, and wherein the carrier protein is covalently linked to the eTEC spacer through an amide linkage, as shown by formula (I):



wherein the glycoconjugate comprises at least one covalent linkage between the carrier protein and the polysaccharide for every 4, 10, 15 or 25 saccharide repeat units of the polysaccharide.

US Pat. No. 11,110,121

COMPOSITIONS COMPRISING HYDROGEN PEROXIDE OR HYDROGEN PEROXIDE DONOR SUBSTANCES

Clariant International Lt...


1. A composition comprisinga) 1% to 10% by weight of at least one substance selected from the group consisting of hydrogen peroxide and hydrogen peroxide-releasing substances;
b) water;
c) at least one polymer having at least one thickening property and having a molecular weight of more than 5000 g/mol; and
d) 0.5 to 1000 ppm of at least one substance selected from the group consisting of compounds of the formula (I) and salts thereof




in which R1 is H or a C1-C4 alkyl radical and R2 is H, an unsubstituted or halogen-substituted, branched or unbranched C1-C20 alkyl radical, an unsubstituted or halogen-substituted C5-C8 cycloalkyl radical, an unsubstituted or halogen-substituted C6-C10 aryl radical or an unsubstituted or halogen-substituted, branched or unbranched C7-C20 aralkyl radical;
wherein the viscosity of the composition is 50 to 100000 mPa·s at 20° C., and wherein the pH of the composition is in the range of 2-7, and wherein the substance selected from the group consisting of compounds of the formula (I) and salts thereof is present in an amount such that the composition exhibits a viscosity stability over 4 weeks from formulation at 40° C. of at least 68%.

US Pat. No. 11,110,114

DINUCLEOTIDES

Oxford University Innovat...


1. A dinucleotide of Formula (I) or Formula (II), or a salt thereof, as shown below:



wherein:
C3 and C4 are the carbon atoms at the 3? and 4? positions of their respective 5-membered rings;
Q1 and Q2 are independently selected from CRpRq, O, S or NRs, wherein Rp and Rq are each independently selected from H, (1-4C)alkyl or halo and R5 is selected from hydrogen or (1-4C)alkyl;
B and B? are each independently:a) a nucleobase;

RP1 is a protecting group;
one of X1 and X2 is (CRaRb)x, wherein x is selected from 1 or 2 and the other is CRaRb, O, NRc or S, wherein Ra and Rb are independently selected from hydrogen, (1-2C)alkyl, hydroxy, amino, halo or mercapto, and Rc is selected from hydrogen or a (1-6C)alkyl;
or one of X1 and X2 is O and the other is NRc;
bond a is either absent or a single bond;
one of X3 and X4 is (CRdRc)y, wherein y is selected from 1 or 2 and the other is CRdRe, O, NRf or S, wherein Rd and Re are independently selected from hydrogen, (1-2C)alkyl, hydroxy, amino, halo or mercapto, and Rf is selected from hydrogen or a (1-6C)alkyl; or
one of X3 and X4 is O and the other is NRf; or
one of X3 and X4 is H and the other is selected from H, OH, NH2, OCH3 or F;
Rz is a solid support or group of formula A1 or A2 shown below:





with the proviso that A1 or A2 is not present when X3 is CRdRe, and Rd and Re is amino, hydroxyl, or mercapto,wherein:




?denotes the point of attachment;
W1 is selected from O, S or (1-4C)alkyl;
?RP2 is a protecting group;
Z+ is a positively charged counter ion;
R1 and R2 are independently selected from hydrogen or (1-6C)alkyl, wherein said alkyl is optionally substituted with one or more substituents selected from halo, nitro, cyano or (1-2C)haloalkyl, with the proviso that the halo substituent is not present on the alpha carbon atom; or
R1 and R2 are linked, such that, together with the nitrogen to which they attached they form a pyrrolidin-1-yl ring which is optionally substituted by one or more substituents selected from (1-4C)alkyl, halo, (1-4C)haloalkyl, (1-4C)haloalkoxy, (1-4C)alkoxy, (1-4C)alkylamino, cyano, or nitro; and
L is a triazole phosphodiester mimic, optionally of Formula A or Formula B:




wherein:




denotes the point of attachment to C3;




denotes the point of attachment to C4;
R2, R3, R4, R5, R6, R7, R8 and R9 are each independently selected from hydrogen or (1-4C)alkyl, wherein each (1-4C)alkyl is optionally substituted with one or more NH2, OH or SH;
V and Y are independently selected from O, S or NRx, wherein Rx is selected from hydrogen or (1-4C)alkyl;
m, n, r and s are integers independently selected from 0 to 2; and
p and q are integers independently selected from 0 to 1;
with the proviso that:
i) the sum of integers m, n, p, q, r and s is either 0, 1, 2, 3, 4, 5 or 6; and
ii) when W1 is a (1-4C)alkyl, RP2 is absent;
iii) bond a is only absent when one of X3 and X4 is H and the other is selected from H, OH, NH2, OCH3 or F.

US Pat. No. 11,110,113

COMPOSITIONS AND METHODS FOR TREATING DEPRESSION

Gentelon, Inc., Carlisle...


1. A method of treating a neuropsychiatric condition, or for promoting wellness and/or energy, the method comprising administering an effective amount of S-adenosyl methionine (SAMe), or a salt thereof; methyl folate, or a salt thereof; and a compound of Formula (I):




or a salt thereof, wherein:R is hydrogen or —C(?O)RA, wherein RA is unsubstituted C10-18 alkyl; and
—C(?O)RB is of the formula:





to a subject in need thereof.

US Pat. No. 11,110,112

METHODS FOR THE USE OF 5'-ADENOSINE DIPHOSPHATE RIBOSE (ADPR)

Invirsa, Inc., Columbus,...


1. A compound having the formula:



or a tautomer, stereoisomer, or isotopologue thereof.

US Pat. No. 11,110,110

CATECHOLAMINE PRODRUGS FOR USE IN THE TREATMENT OF PARKINSON'S DISEASE


1. A method for the treatment of a neurodegenerative disease selected from Parkinson's Disease, Huntington's disease, Restless leg syndrome and Alzheimer's disease; or a neuropsychiatric disease or disorder selected from schizophrenia, attention deficit hyperactivity disorder and drug addiction; wherein said method comprises administering to a patient in need thereof a pharmaceutical composition comprising a compound according to formula (Id):



or a pharmaceutically acceptable salt thereof, wherein:
R1 is H and R2 is substituent (i) below; or
R1 is substituent (i) below and R2 is H; or
R1 and R2 are both represented by substituent (i) below;




wherein * indicates the attachment point; and
wherein the carbon atom at the attachment point on substituent (i) is in the S-configuration;
and one or more pharmaceutically acceptable excipients.

US Pat. No. 11,110,108

METHOD FOR TREATING CANCER USING A COMBINATION OF DNA-DAMAGING AGENTS AND DNA-PK INHIBITORS

VERTEX PHARMACEUTICALS IN...


1. A method of treating a proliferative disorder in a subject, the method comprising:administering to a subject in need thereof a therapeutically effective amount of DNA-damaging agent and
administering to the subject a therapeutically effective amount of DNA-PK inhibitor between about 8 and about 48 hours after administration of the DNA-damaging agent, wherein the DNA-damaging agent is a doxorubicin agent;
wherein the proliferative disorder is a cancer selected from the group consisting of non-small cell lung cancer, small cell lung cancer, colorectal cancer, breast cancer, hepatocellular carcinoma, endometrial cancer, and ovarian cancer; and
wherein the DNA-PK inhibitor is represented by Formula (B-I):





or a pharmaceutically acceptable salt thereof,
wherein:Q is N or CH;
R1 is hydrogen, CH3, or CH2CH3, or R1 and the carbon to which it is bound form a C?CH2 group;
Ring A is a ring system selected from the group consisting of:










RA1 is hydrogen, halogen, C1-4alkyl, C0-4alkyl-C3-6cycloalkyl, C0-4alkyl-ORA1a, C0-4alkyl-SRA1a C0-4alkyl-C(O)N(RA1a)2, C0-4alkyl-CN, C0-4alkyl-S(O)—C1-4alkyl, C0-4alkyl-S(O)2—C1-4alkyl, C0-4alkyl-C(O)ORA1b, C0-4alkyl-C(O)C1-4alkyl, C0-4alkyl-N(RA1b)C(O)RA1a, C0-4alkyl-N(RA1b)S(O)2RA1a, C0-4alkyl-N(RA1a)2, C0-4alkyl-N(RA1b)(3-6 membered-cycloalkyl), C0-4alkyl-N(RA1b)(4-6 membered-heterocyclyl), N(RA1b)C2-4alkyl-N(RA1a)2, N(RA1b)C2-4alkyl-ORA1a, N(RA1b)C1-4alkyl-(5-10 membered heteroaryl), N(RA1b)C1-4alkyl-(4-6 membered heterocyclyl), N(RA1b)C2-4alkyl-N(RA1b)C(O)RA1a, C0-4alkyl-N(RA1b)C(O)C1-4alkyl, C0-4alkyl-N(RA1b)C(O)OC1-4alkyl, C0-4alkyl-(phenyl), C0-4alkyl-(3-10 membered-heterocyclyl), C0-4alkyl-C(O)-(4-6 membered-heterocyclyl), C0-4alkyl-O—C0-4alkyl-(4-6 membered-heterocyclyl), C0-4alkyl-(5-6 membered-heteroaryl), C0-4alkyl-C(O)-(5-6 membered-heteroaryl), C0-4alkyl-O—C0-4alkyl-(5-6 membered-heteroaryl), C0-4alkyl-N(RA1a)(4-6 membered-heterocyclyl), or C0-4alkyl-N(RA1b)(5-6 membered-heteroaryl), wherein each of said RA1 heterocyclyl is a ring system selected from aziridinyl, oxetanyl, tetrahydropyran, tetrahydrofuranyl, dioxanyl, dioxolanyl, azetidinyl, pyrrolidinyl, pyrrolidinonyl, pyrrolidinedionyl, morpholinyl, piperidinyl, piperazinyl, piperazinonyl, tetrahydrothiophenedioxidyl, 1,1-dioxothietanyl, 2-oxa-6-azaspiro[3.4]octanyl, and isoindolinonyl wherein each of said RA1 heteroaryl is a ring system selected from furanyl, thiophenyl, imidazolyl, benzoimidazolyl, oxazolyl, oxadiazolyl, thiazolyl, pyrazolyl, thiadiazolyl, pyridinyl, pyrimidinyl, pyrazinyl, triazolyl, and tetrazolyl, and wherein each of said RA1 alkyl, cycloalkyl, phenyl, heterocyclyl, and heteroaryl groups is optionally substituted with up to three F atoms, up to two C1-2alkyl groups, a C3-6cycloalkyl group, a phenyl group, a benzyl group, an alkenyl-C0-2alkyl group, an alkynyl-C0-2alkyl group, up to two C0-2alkyl-ORA1b groups, a C0-2alkyl-N(RA1b)2 group, a SC1-4alkyl group, a S(O)2C1-4alkyl group, a C(O)RA1b group, a C(O)ORA1b group, a C(O)N(RA1b)2 group, a —CN group, or a C4-6heterocyclic ring system selected from oxetanyl, tetrahydrofuranyl, tetrahydropyran, piperidinyl, and morpholinyl;
each RA1a is, independently, hydrogen, C1-4alkyl, C3-6cycloalkyl, C4-6heterocyclyl selected from oxetanyl, tetrahydrofuranyl, tetrahydropyran, pyrrolidinyl, and piperidinyl, C5-6heteroaryl selected from imidazolyl, triazolyl, tetrazolyl, pyrazolyl, thiophenyl, thiazolyl, pyridinyl, pyrimidinyl, and pyrazinyl, or two RA1a and an intervening nitrogen atom form a 3-6 membered heterocyclic ring selected from aziridinyl, azetidinyl, pyrrolidinyl, pyrrolidinonyl, piperidinyl, piperidinonyl, tetrahydropyridinyl, piperazinyl, and morpholinyl, wherein each of said RA1a alkyl, cycloalkyl, heterocyclyl, and heteroaryl groups is optionally substituted with up to three F atoms, up to three 2H atoms, up to two C1-2alkyl groups, a C3-6cycloalkyl group, up to two C0-2alkyl-ORA1b groups, a C0-2alkyl-N(RA1b)2 group, a SC1-4alkyl group, a C(O)RA1b group, a C(O)ORA1b group, a C(O)N(RA1b)2 group, or a —CN group;
each RA1b is, independently, hydrogen, C1-2alkyl, or C3-4cycloalkyl;
RA2 is hydrogen, C1-4alkyl, C0-4alkyl-C3-6cycloalkyl, C0-2alkyl-(4-6 membered)heterocyclyl, C2-4alkyl-ORA2a, C0-2alkyl-C(O)NRA2a)2, C0-2alkyl-S(O)2—C1-4alkyl, C0-2alkyl-C(O)OC1-4alkyl, C0-2alkyl-C(O)-(4-6 membered)heterocyclyl, wherein each of said heterocyclyl is selected from oxetanyl, tetrahydropyran, tetrahydrofuranyl, dioxanyl, dioxolanyl, azetidinyl, pyrrolidinyl, pyrrolidinonyl, pyrrolidinedionyl, morpholinyl, piperidinyl, piperazinyl, piperazinonyl, and 1,1-dioxothietanyl, and each of said RA2 groups except hydrogen is optionally substituted with up to three F atoms, up to two C1-2alkyl groups, a C3-6cycloalkyl group, an alkenyl-C0-2alkyl group, an alkynyl-C0-2alkyl group, up to two ORA2b groups, a C0-2alkyl-N(RA2b)2 group, a SC1-4alkyl group, a S(O)2C1-4alkyl group, a C(O)RA2b group, a C(O)ORA2b group, a C(O)N(RA2b)2 group, or a —CN group;
each RA2a is, independently, hydrogen, C1-4alkyl, a C5-6heteroaryl selected from imidazolyl, triazolyl, tetrazolyl, pyrazolyl, thiophenyl, thiazolyl, pyridinyl, pyrimidinyl, and pyrazinyl, or two RA2a and an intervening nitrogen atom form a 3-6 membered heterocyclic ring selected from aziridinyl, azetidinyl, pyrrolidinyl, pyrrolidinonyl, piperidinyl, piperidinonyl, tetrahydropyridinyl, piperazinyl, and morpholinyl;
each RA2b is, independently, hydrogen, C1-4alkyl, or C3-4cycloalkyl;
RA3 is hydrogen or C1-2alkyl;
each RA4 is, independently, deuterium, halogen, CN, C1-4alkyl, or OC1-4alkyl, wherein each RA4 alkyl is optionally substituted with up to 3 F atoms, two non-geminal OH groups, or one OC1-2alkyl, or two RA4 together with an intervening saturated carbon atom form a spiro-linked cyclopropyl or cyclobutyl ring;
n is 0-3;
Ring B is a ring system selected from the group consisting of:








RB1 is hydrogen, C1-4alkyl, (CH2)0-1C3-6cycloalkyl, C(O)C1-2alkyl, (CH2)0-1-(4-6 membered)heterocyclyl ring wherein said heterocyclic ring is selected from oxetanyl, tetrahydrofuranyl, tetrahydropyran, dioxanyl, dioxolanyl, and pyrrolidinonyl, or (CH2)1-2(5-6 membered)heteroaryl ring wherein said heteroaryl ring is selected from pyridinyl, imidazolyl, and pyrazolyl, and wherein each of said RB1 alkyl, cycloalkyl, phenyl, benzyl, heterocyclyl and heteroaryl groups is optionally substituted with up to 3 F atoms, up to two C1-2alkyl groups, two non-geminal OH groups, or one OC1-2alkyl;
RB2 is hydrogen, C1-4alkyl, OC1-4alkyl;
each RB3 is, independently, hydrogen, halogen, C1-4alkyl, C2-4alkenyl, C2-4alkynyl, CN, C(O)H, C(O)C1-4alkyl, C(O)OC1-4alkyl, C(O)C1-4alkyl, C(O)NH2, C(O)NHC1-4alkyl, C(O)NH(CH2)0-1C3-6cycloalkyl, C(O)NHCH2oxetanyl, C(O)NHCH2tetrahydrofuranyl, C(O)NHCH2tetrahydropyranyl, C(O)NHphenyl, C(O)NHbenzyl, C(O)NHOH, C(O)NHOC1-4alkyl, C(O)NHO(CH2)0-1C3-6cycloalkyl, C(O)NHO(CH2)0-1oxetanyl, C(O)NHO(CH2)0-1tetrahydrofuranyl, C(O)NHO(CH2)0-1tetrahydropyranyl, C(O)NHOphenyl, C(O)NHObenzyl, NH2, NHC(O)C1-4alkyl, OC1-4alkyl, SC1-4alkyl, S(O)C1-4alkyl, or a 5-membered-heteroaryl ring system selected from furanyl, thiophenyl, imidazolyl, pyrrole, pyrazolyl, and oxadiazolyl, wherein each RB3 group except hydrogen or halogen is optionally substituted with Cl, up to three F atoms, up to two non-geminal OH groups, up to two OC1-2alkyl, one NH2, one NHC1-4alkyl, one NHC(O)C1-2alkyl, or one N(C1-2alkyl)2;
each RB4 is, independently, hydrogen, deuterium, halogen, C1-4alkyl, OC1-4alkyl, SC1-4alkyl, NH2, NH(C1-4alkyl), N(C1-4alkyl)2, NHC(O)C1-4alkyl, C(O)OH, C(O)OC1-4alkyl, C(O)NH2, C(O)NHC1-4alkyl, C(O)N(C1-4alkyl)2, CN, a morpholinyl ring, or an imidazolyl ring, wherein each RB4 alkyl is optionally substituted with up to 3 F atoms, two non-geminal OH groups, or one OC1-2alkyl;
RB5 is hydrogen, C1-4alkyl, C(O)C1-4alkyl, C(O)OC1-4alkyl, C(O)NH2, C(O)NHC1-4alkyl, or C(O)N(C1-4alkyl)2, wherein said RB5 alkyl is optionally substituted with up to 3 F atoms, two non-geminal OH groups, or one OC1-2alkyl and
RB6 is F or C1-2alkyl, or two RB6 and an intervening carbon atom form a spirocyclopropyl or spirocyclobutyl ring.

US Pat. No. 11,110,107

METHODS FOR TREATMENT OF CANCER BY TARGETING SIRT5

CORNELL UNIVERSITY, Itha...


1. A compound that inhibits Sirt5 demalonylase or desuccinylase activity, having the formula:



wherein:R1 is a carboxylate alkyl ester;
R2 is S;
X0, X1, X2, X3, X6, and X7 are each —CH2—;
X4 is —NR5—, wherein R5 is H, methyl, ethyl, isopropyl, phenyl, or benzyl;
X5 is —CH2— or —NR5—;
R3 and R4 are independently selected from H, hydrocarbon (R), amino acid, dipeptide, tripeptide, oligopeptide, protein, nucleobase, nucleotide, dinucleotide, trinucleotide, oligonucleotide, monosaccharide, disaccharide, oligosaccharide, and protecting groups or a combination thereof or modified form thereof.


US Pat. No. 11,110,106

STING AGONISTS FOR TREATING BLADDER CANCER AND SOLID TUMORS

VENENUM BIODESIGN, LLC, ...


1. A method for treating bladder cancer comprising administering to a patient in need of treatment for bladder cancer a therapeutically effective amount of a compound of formula 1




or pharmaceutically acceptable salt thereof.

US Pat. No. 11,110,104

GLUTAMINE ANTAGONISTS FOR THE TREATMENT OF COGNITIVE DEFICITS AND PSYCHIATRIC DISORDERS

The Johns Hopkins Univers...


1. A method for treating a subject having a cognitive deficit, the method comprising administering to the subject a compound having formula (II):



or a pharmaceutically acceptable salt thereof;
wherein:
R1 is selected from the group consisting of H and C1-6 alkyl;
R3 and R4 are independently selected from the group consisting of H, C1-C6 alkyl, substituted C1-C6 alkyl, aryl, and substituted aryl; and
R10 is C1-6 alkyl,
in an amount effective to treat the cognitive deficit.

US Pat. No. 11,110,103

INHIBITORS OF GLUCOCORTICOID RECEPTOR

ORIC PHARMACEUTICALS, INC...


1. A compound having the structure of Formula (I), or a pharmaceutically acceptable salt thereof:




whereinR1 is —NR3S(O)2R6, —NR3S(O)2NR3R4, -alkylNR3S(O)2R6, -alkylNR3S(O)2NR3R4, —NR3S(O)R6, —Oaralkyl, —C(O)NR3R4, —OC(O)OR5, —C(O)OR5, —OC(O)NR3R4, —S(O)2NR3R4, —S(O)2R6, or —S(O)R6;
R3 and R4 are each independently —H, optionally substituted alkyl, haloalkyl, optionally substituted carbocyclyl, optionally substituted carbocyclylalkyl, optionally substituted heteroalkyl, optionally substituted aryl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heteroaryl, —S(O)2R6, —C(O)N(R10)2, —C(O)R5, or —C(O)OR5;
or R3 and R4 attached to the same N atom are taken together with the N atom to which they are attached to form a substituted or unsubstituted heterocycle;
R5 is optionally substituted alkyl, haloalkyl, optionally substituted carbocyclyl, optionally substituted aryl, optionally substituted heterocyclyl, or optionally substituted heteroaryl;
R6 is optionally substituted alkyl, haloalkyl, optionally substituted carbocyclyl, optionally substituted heteroalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted heterocyclyl, or optionally substituted heteroaryl;
R7 and R8 are each independently —H, optionally substituted alkyl, haloalkyl, halo, optionally substituted carbocyclyl, optionally substituted carbocyclylalkyl, optionally substituted heteroalkyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, —OH, —OR5, —NR3R4, —C(O)NR3R4, —CN, —S(O)2R6, —C(O)2H, —C(O)R5, or —C(O)OR5;
or R7 and R8 are taken together with the atom to which they are attached to form a substituted or unsubstituted ring containing 0-2 heteroatoms selected from the group consisting of —O—, —NH—, —NR6—, —S—, and —S(O)2; and
each R10 is independently H, optionally substituted alkyl, haloalkyl, optionally substituted carbocyclyl, optionally substituted heteroalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted heterocyclyl, or optionally substituted heteroaryl.

US Pat. No. 11,110,102

ANTIFUNGAL AGENTS USED IN COMBINATION

Scynexis, Inc., Jersey C...


1. A method of treating an Aspergillus infection in a subject in need thereof, the method comprising administering to the subject:(a) a first therapeutic agent that is a compound of Formula (II):





which is (1S,4aR,6aS,7R,8R,10aR,10bR,12aR,14R,15R)-15-[[2-amino-2,3,3-trimethylbutyl]oxy]-8-[(1R)-1,2-dimethylpropyl]-14-[5-(4-pyridinyl)-1H-1,2,4-triazol-1-yl]-1,6,6a,7,8,9,10,10a,10b,11,12,12a-dodecahydro-1,6a,8,10a-tetramethyl-4H-1,4a-propano-2H-phenanthro[1,2-c]pyran-7-carboxylic acid,or a pharmaceutically acceptable salt thereof; and
(b) a second therapeutic agent that is isavuconazole,
wherein the first therapeutic agent is administered orally at a dose of 50 mg to 1000 mg, and the second therapeutic agent is administered at a dose of 50 mg to 1000 mg, and
wherein the dose of the first therapeutic agent and the dose of the second therapeutic agent are each administered at least once or twice per day for at least one week.

US Pat. No. 11,110,100

GANAXOLONE FOR USE IN TREATMENT OF STATUS EPILEPTICUS

Marinus Pharmaceuticals, ...


1. A method of treating status epilepticus (SE), comprising administering to a subject in need thereof an effective amount of ganaxolone to suppress SE, wherein the effective amount of ganaxolone is administered as an intravenous bolus plus continuous infusion to produce and maintain a ganaxolone plasma concentration of about 500 ng/ml to about 1000 ng/ml for about 8 hours to about 12 hours.

US Pat. No. 11,110,095

PYRIMIDINE COMPOUNDS AS JAK KINASE INHIBITORS


1. A method of treating a gastrointestinal inflammatory disease selected from the group consisting of collagenous colitis, lymphocytic colitis, Behcet's disease, ileitis, eosinophilic esophagitis, graft versus host disease-related colitis, Crohn's disease, celiac disease, ulcerative colitis, immune checkpoint inhibitor induced colitis and infectious colitis, in a mammal, the method comprising administering to the mammal a compound of formula (I):



whereinR1 is selected from:(a) —S(O)2R4, wherein R4 is selected from:C1-4alkyl, wherein C1-4alkyl is optionally substituted with CN, —OC1-3alkyl, or C3-6cycloalkyl,
heterocyclyl containing 4 to 6 ring atoms including one nitrogen atom,
?wherein any heterocyclyl is optionally substituted with CN, C3-6cycloalkyl,
pyridinyl, wherein pyridinyl is optionally substituted with fluoro, and phenyl;

(b) C1-4alkyl, wherein C1-4alkyl is optionally substituted with —CN








orpyridinyl, wherein pyridinyl is optionally substituted with —CN; and

(c) —C(O)R5, wherein R5 is selected from:C1-4alkyl, wherein C1-4alkyl is optionally substituted with C3-6cycloalkyl, or with one or two fluoro,
—OC1-4alkyl,
C3-6cycloalkyl, and
morpholinyl;


R2 is hydrogen or methyl;
R3 is C1-3alkyl; and
n is 1 or 2;
or a pharmaceutically-acceptable salt thereof.


US Pat. No. 11,110,091

MODULATORS OF TOLL-LIKE RECEPTORS

Gilead Sciences, Inc., F...


1. A compound of Formula II:



or a pharmaceutically acceptable salt thereof, wherein:
Y—Z is —CR4R5—CR4R5;
L1 is —NH— or —O—;
R1 is C1-C6 alkyl C3-C12 saturated carbocyclyl, C4-C20 saturated carbocyclylalkyl, or C6-C20 arylalkyl;
X1 is —CH2;
D is phenyl substituted with -L2-NR6R7;
each L2 is independently C1-C6 alkylene;
each R3 is independently halogen, cyano, or C1-C6 haloalkyl;
n is 0 or 1;
R4 and R5 are each H;
R6 and R7 are each independently H, C1-C6 alkyl, or C4-C20 saturated carbocyclylalkyl, —C(O)R8, —S(O)R8, —S(O)2R8, or —C(O)OR8; or
R6 and R7, taken together with the nitrogen to which they are both attached, form a 4-6 membered saturated heterocycle comprising 0 to 2 heteroatoms selected from N, O, or S; and
R8 is H or C1-C6 alkyl.

US Pat. No. 11,110,090

AMINOPYRIMIDINES AS ALK INHIBITORS

THE REGENTS OF THE UNIVER...


1. A method of treating a patient comprising administering to the patient a therapeutically effective amount of a compound having Formula I, or a pharmaceutically acceptable salt, hydrate, or solvate thereof, wherein the patient has a cancer in which anaplastic lymphoma kinase (ALK) has a role and the compound of Formula I has a structure:



or a pharmaceutically acceptable salt or solvate thereof, wherein:Rla and R1b are independently selected from the group consisting of hydrogen, C1-6 alkyl, and C3-8 cycloalkyl;
R2a and R2b are independently selected from the group consisting of hydrogen, C1-6 alkyl, and C3-8 cycloalkyl;
R3 is selected from the group consisting of hydrogen, C1-6 alkyl, C3-6 cycloalkyl, and C4-8 heterocyclo,
R4 is selected from the group consisting of C1-4 alkyl, and C3-6 cycloalkyl;
R5 is halo;
R6 is selected from the group consisting of C1-4 alkyl, and C3-6 cycloalkyl; and
R7 is selected from the group consisting of hydrogen, C1-4 alkyl, and C3-6 cycloalkyl, with proviso that when R1a, R1b, R2a, and R2b are each hydrogen, then R3 is selected from the group consisting of C3-6 cycloalkyl and C4-8 heterocyclo.


US Pat. No. 11,110,089

PYRIDAZINONES AND THEIR USE IN THE TREATMENT OF CANCER

The United States of Amer...


1. A compound of formula I



or a pharmaceutically acceptable salt thereof, wherein:
W represents C1 alkylene optionally substituted by one or more groups independently selected from R4;
X represents O;
Y represents C1-6 alkyl optionally substituted by one or more groups independently selected from G1a, C2-6 alkenyl optionally substituted by one or more groups independently selected from G1a, C2-6 alkynyl optionally substituted by one or more groups independently selected from G1a, heterocycloalkyl optionally substituted by one or more groups independently selected from G1b, aryl optionally substituted by one or more groups independently selected from G1c, or heteroaryl optionally substituted by one or more groups independently selected from G1d;
Z represents O, S or NR5;
R1 represents H, halo, Ra1, —CN, —C(Qa1)Rb1, —C(Qb1)N(Rc1)Rd1, —C(Qc1)ORe1, —S(O)nRf1, —S(O)pN(Rg1)Rh1, —S(O)pORi1 or —NO2;
R2 represents H, halo, —CN or —N3;
R3 represents H, halo or Rdj1;
R4 represents halo, C1-6 alkyl optionally substituted by one or more groups independently selected from G1e, C2-6 alkenyl optionally substituted by one or more groups independently selected from G1e, or C2-6 alkynyl optionally substituted by one or more groups independently selected from G1e;
R5 represents H, Rk1, —OR1l or —N(Rm1)Rn1,
Qa1 to Qc1 each independently represents ?O, ?S, ?NRo1 or ?N(ORp1);
each Ra1, Rf1, Rj1 and Rk1 independently represents C1-6 alkyl optionally substituted by one or more groups independently selected from G2a, C2-6 alkenyl optionally substituted by one or more groups independently selected from G2a, C2-6 alkynyl optionally substituted by one or more groups independently selected from G2a, or heterocycloalkyl optionally substituted by one or more groups independently selected from G2b;
each Rb1, Rc1, Rd1, Re1, Rg1, Rh1, Ri1, Rj1, Rl1, Rm1, Ro1 and Rp1 independently represents H, C1-6 alkyl optionally substituted by one or more groups independently selected from G2a, C2-6 alkenyl optionally substituted by one or more groups independently selected from G2a, C2-6 alkynyl optionally substituted by one or more groups independently selected from G2a, or heterocycloalkyl optionally substituted by one or more groups independently selected from G2b,
or any two Rc1 and Rd1, Rg1 and Rh1 and/or Rm1 and Rn1 are linked together to form, along with the nitrogen atom to which they are attached, a 3- to 6-membered ring, which ring optionally contains one further heteroatom and which ring optionally is substituted by one or more groups independently selected from halogen, C1-3 alkyl optionally substituted by one or more halogens, C2-3 alkenyl optionally substituted by one or more halogens, C2-3 alkynyl optionally substituted by one or more halogens, and ?O;
each G1a, G1b, G1c and G1d represent halogen, Ra2, —CN, -Aa1-C(Qa2)Ra2, -Ab1-C(Qb2)N(Rc2)Rd2, -Ac1-C(Qc2)ORe2, -Ad1-S(O)Rf2, -Ae1-S(O)qC(O)Rg2, -Af1-S(O)qN(Rh2)Ri2, -Ag1-S(O)qORj2, —N3, —N(Rk2)Rl2, —N(H)CN, —NO2, —ORm2, —SRn2 or ?Qd2,
Aa1 to Ag1 each independently represents a single bond, —N(R6)—, —C(Qe2)N(R7)— or —O—;
Qa2 to Qe2 each independently represents ?O, ?S, ?NRo2 or ?N(ORp2);
each R6 and R7 independently represents H, C1-6 alkyl optionally substituted by one or more F, C2-6 alkenyl optionally substituted by one or more F, or C2-6 alkynyl optionally substituted by one or more F;
each Ra2 and Rf2 independently represents C1-6 alkyl optionally substituted by one or more groups independently selected from G3a, C2-6 alkenyl optionally substituted by one or more groups independently selected from G3a, C2-6 alkynyl optionally substituted by one or more groups independently selected from G3a, or heterocycloalkyl optionally substituted by one or more groups independently selected from G3b;
each Rb2, Rc2, Rd2, Re2, Rg2, Rh2, Ri2, Rj2, Rk2, Rl2, Rm2, Rn2, Ro2 and Rp2 independently represents H, C1-6 alkyl optionally substituted by one or more groups independently selected from G3a, C2-6 alkenyl optionally substituted by one or more groups independently selected from G3a, C2-6 alkynyl optionally substituted by one or more groups independently selected from G3a, or heterocycloalkyl optionally substituted by one or more groups independently selected from G3b; or
any two Rc2 and Rd2, Rh2 and Ri2 and/or Rk2 and Rl2 are linked together to form, along with the nitrogen atom to which they are attached, a 3- to 6-membered ring, which ring optionally contains one further heteroatom and which ring optionally is substituted by one or more groups independently selected from halogen, C1-3 alkyl optionally substituted by one or more halogens, C2-3 alkenyl optionally substituted by one or more halogens, C2-3 alkynyl optionally substituted by one or more halogens, and ?O;
each G1e independently represents halo, R2a, —CN, —N(Ra3)Rb3, —ORc3 or —SRd3;
Ra3, Rb3, Rc3 and Rd3 each independently represents H, C1-6 alkyl optionally substituted by one or more F, C2-6 alkenyl optionally substituted by one or more F, or C2-6 alkynyl optionally substituted by one or more F;
or Ra3 and Rb3 are linked together to form, along with the nitrogen atom to which they are attached, a 3- to 6-membered ring, which ring optionally contains one further heteroatom and which ring optionally is substituted by one or more groups independently selected from fluoro, C1-3 alkyl optionally substituted by one or more fluoro, C2-3 alkenyl optionally substituted by one or more fluoro, C2-3 alkynyl optionally substituted by one or more fluoro, and ?O;
each G2a and G2b independently represents halo, —CN, —N(Ra4)Rb4, —ORc4, —SRd4 or ?O;
each Ra4, Rb4, Rc4 and Rd4 independently represents H, C1-6 alkyl optionally substituted by one or more fluoro, C2-6 alkenyl optionally substituted by one or more fluoro, or C2-6 alkynyl optionally substituted by one or more fluoro;
or Ra4 and Rb4 are linked together to form, along with the nitrogen atom to which they are attached, a 3- to 6-membered ring, which ring optionally contains one further heteroatom and which ring optionally is substituted by one or more groups independently selected from fluoro, C1-3 alkyl optionally substituted by one or more fluoro, C2-3 alkenyl optionally substituted by one or more fluoro, C2-3 alkynyl optionally substituted by one or more fluoro, and ?O;
each G3a and G3b independently represents halo, —CN, —N(Ra5)Rb5, —ORc5, —SRd5 or ?O;
each Ra5, Rb5, RCc5 and Rd5 independently represents H, C1-6 alkyl optionally substituted by one or more fluoro, C2-6 alkenyl optionally substituted by one or more fluoro, or C2-6 alkynyl optionally substituted by one or more fluoro;
or Ra5 and Rb5 are linked together to form, along with the nitrogen atom to which they are attached, a 3- to 6-membered ring, which ring optionally contains one further heteroatom and which ring optionally is substituted by one or more groups independently selected from fluoro, C1-3 alkyl optionally substituted by one or more fluoro, C2-3 alkenyl optionally substituted by one or more fluoro, C2-3 alkynyl optionally substituted by one or more fluoro, and ?O;
each n independently represents 0, 1 or 2,
each p independently represents 1 or 2,
each q independently represents 1 or 2, with the provisos that:
(A) the compound of formula I is not a compound selected from
4,5-dichloro-2-((5-(4-chlorophenyl)-1,3,4-oxadiazol-2-yl)methyl)pyridazin-3(2H)-one,
4,5-dichloro-2-((5-phenyl-1,3,4-oxadiazol-2-yl)methyl)pyridazin-3(2H)-one,
4,5-dichloro-2-((5-(p-tolyl)-1,3,4-oxadiazol-2-yl)methyl)pyridazin-3(2H)-one,
4,5-dichloro-2-(1-(5-(4-chlorophenyl)-1,3,4-oxadiazol-2-yl)propyl)pyridazin-3(2H)-one,
4,5-dichloro-2-(1-(5-phenyl-1,3,4-oxadiazol-2-yl)propyl)pyridazin-3(2H)-one,
4,5-dichloro-2-(1-(5-(p-tolyl)-1,3,4-oxadiazol-2-yl)propyl)pyridazin-3(2H)-one, and
4,5-dichloro-2-(1-(5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl)propyl)pyridazin-3(2H)-one;
and
(B) the compound of formula I is not a compound selected from
2-((5-(thiophen-2-yl)-1,3,4-oxadiazol-2-yl)methyl)-6-(trifluoromethyl)pyridazin-3(2H)-one,
4,5-dibromo-2-((5-methyl-1,3,4-oxadiazol-2-yl)methyl)pyridazin-3(2H)-one,
5-iodo-2-((5-methyl-1,3,4-oxadiazol-2-yl)methyl)pyridazin-3(2H)-one,
2-((5-ethyl-1,3,4-oxadiazol-2-yl)methyl)-5-iodopyridazin-3(2H)-one,
4,5-dichloro-2-((5-ethyl-1,3,4-oxadiazol-2-yl)methyl)pyridazin-3(2H)-one,
4,5-dibromo-2-((5-ethyl-1,3,4-oxadiazol-2-yl)methyl)pyridazin-3(2H)-one,
4,5-dichloro-2-((5-methyl-1,3,4-oxadiazol-2-yl)methyl)pyridazin-3(2H)-one,
2-((5-(tert-butyl)-1,3,4-oxadiazol-2-yl)methyl)-4,5-dichloropyridazin-3(2H)-one,
2-((5-isopropyl-1,3,4-oxadiazol-2-yl)methyl)-6-(trifluoromethyl)pyridazin-3(2H)-one,
6-(tert-butyl)-2-((5-(4-chlorophenyl)-1,3,4-oxadiazol-2-yl)methyl)pyridazin-3(2H)-one,
2-((5-(3-methoxyphenyl)-1,3,4-oxadiazol-2-yl)methyl)-6-methylpyridazin-3(2H)-one,
6-methyl-2-((5-(4-nitrophenyl)-1,3,4-oxadiazol-2-yl)methyl)pyridazin-3(2H)-one,
5,6-diethyl-2-((5-isopropyl-1,3,4-oxadiazol-2-yl)methyl)-3-oxo-2,3-dihydropyridazine-4-carbonitrile,
2-((5-(4-bromophenyl)-1,3,4-oxadiazol-2-yl)methyl)-5,6-diethyl-3-oxo-2,3-dihydropyridazine-4-carbonitrile,
4,5-dichloro-2-((5-(4-nitrophenyl)-1,3,4-oxadiazol-2-yl)methyl)pyridazin-3(2H)-one,
4,5-dichloro-2-((5-(3,4,5-trimethoxyphenyl)-1,3,4-oxadiazol-2-yl)methyl)pyridazin-3(2H)-one,
2-((5-cyclopropyl-1,3,4-oxadiazol-2-yl)methyl)-5,6-diethyl-3-oxo-2,3-dihydropyridazine-4-carbonitrile,
6-cyclopropyl-2-((5-ethyl-1,3,4-oxadiazol-2-yl)methyl)-4-(trifluoromethyl)pyridazin-3(2H)-one,
2-((5-(tert-butyl)-1,3,4-oxadiazol-2-yl)methyl)-6-cyclopropyl-4-(trifluoromethyl)pyridazin-3(2H)-one,
6-cyclopropyl-2-((5-methyl-1,3,4-oxadiazol-2-yl)methyl)-4-(trifluoromethyl)pyridazin-3(2H)-one,
6-cyclopropyl-2((5-cyclopropyl-1,3,4-oxadiazol-2-yl)methyl)-4-(trifluoromethyl)pyridazin-3(2H)-one,
5,6-dimethyl-2-((5-(4-nitrophenyl)-1,3,4-oxadiazol-2-yl)methyl)-3-oxo-2,3-dihydropyridazine-4-carbonitrile,
5,6-dimethyl-3-oxo-2-((5-(3,4,5-trimethoxyphenyl)-1,3,4-oxadiazol-2-yl)methyl)-2,3-dihydropyridazine-4-carbonitrile,
2-((5-(4-bromophenyl)-1,3,4-oxadiazol-2-yl)methyl)-6-cyclopropyl-4-(trifluoromethyl)pyridazin-3(2H)-one,
2-((5-(3-bromophenyl)-1,3,4-oxadiazol-2-yl)methyl)-6-cyclopropyl-4-(trifluoromethyl)pyridazin-3 (2H)-one,
6-cyclopropyl-4-(trifluoromethyl)-2-((5-(3,4,5-trimethoxyphenyl)-1,3,4-oxadi azol-2-yl)methyl)pyridazin-3 (2H)-one,
2-((5-(3-bromophenyl)-1,3,4-oxadiazol-2-yl)methyl)-4,5-dichloropyridazin-3 (2H)-one,
4,5-dichloro-2-((5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl)methyl)pyridazin-3 (2H)-one,
2-((5-(5-bromofuran-2-yl)-1,3,4-oxadiazol-2-yl)methyl)-4,5-dichloropyridazin-3 (2H)-one,
5,6-dimethyl-3-oxo-2-((5-phenyl-1,3,4-oxadiazol-2-yl)methyl)-2,3-dihydropyridazine-4-carbonitrile,
2-((5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl)methyl)-5,6-dimethyl-3-oxo-2,3-dihydropyridazine-4-carbonitrile,
2-((5-(4-bromophenyl)-1,3,4-oxadiazol-2-yl)methyl)-4,5-dichloropyridazin-3 (2H)-one,
4,5-dichloro-2-((5-(thiophen-2-yl)-1,3,4-oxadiazol-2-yl)methyl)pyridazin-3 (2H)-one,
2-((5-(2-bromophenyl)-1,3,4-oxadiazol-2-yl)methyl)-4,5-dichloropyridazin-3(2H)-one.

US Pat. No. 11,110,086

COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE AND COMBINATION THERAPIES THEREOF

VERTEX PHARMACEUTICALS IN...


1. A method of treating cancer in a patient, comprising administering to a patient in need thereof a therapeutically effective amount of an ATR inhibitor compound of formula:




or a pharmaceutically acceptable salt thereof; andan inhibitor of poly(ADP-ribose) polymerase (PARP) I and/or II, wherein the cancer is selected from the group consisting of melanoma, lung cancer, osteosarcoma, ovarian cancer, colorectal cancer, and breast cancer.

US Pat. No. 11,110,083

METHODS FOR TREATING LIVER DISORDERS USING FXR AGONISTS

Novartis AG, Basel (CH)


1. A method for treating a condition mediated by Farnesoid X receptor (FXR), comprising administering to a subject a compound of Formula (I)



or a stereoisomer, an enantiomer, a pharmaceutically acceptable salt thereof, an amino acid conjugate or acyl glucuronide conjugate thereof, at a dose of about 3 ?g to about 100 ?g;
wherein said amino acid conjugate or acyl glucuronide conjugate is selected from:
2-({2-[(1R,3R,5S)-3-({5-cyclopropyl-3-[2-(trifluoromethoxy)phenyl]-1,2-oxazol-4-yl}methoxy)-8-azabicyclor[3.2.1]octan-8-yl]-4-fluoro-1,3-benzothiazol-6-yl}formamido)acetic acid;
2-({2-[(1R,3R,5S)-3-({5-cyclopropyl-3-[2-(trifluoromethoxy)phenyl]-1,2-oxazol-4-yl}methoxy)-8-azabicyclor[3.2.1]octan-8-yl]-4-fluoro-1,3-benzothiazol-6-yl}formamido)ethane-1-sulfonic acid; and
(2S,3S,4S,5R,6S)-6-((2-((1R,3S,5S)-3-((5-cyclopropyl-3-(2-(trifluoromethoxy)phenyl)isoxazol-4-yl)methoxy)-8-azabicyclo[3.2.1]octan-8-yl)-4-fluorobenzo[d]thiazole-6-carbonyl)oxy)-3,4,5-trihydroxytetrahydro-2H-pyran-2-carboxylic acid; and
wherein said condition mediated by FXR is primary biliary cholangitis (PBC).

US Pat. No. 11,110,082

TYROSINE KINASE INHIBITORS

Rigel Pharmaceuticals, In...


1. A compound having the structure formula (I):



or a pharmaceutically acceptable salt, or N-oxide thereof, or a solvate or hydrate thereof,
whereinX is hydrogen, Cak(C0-C6alkyl), Hca(C0-C6alkyl), Ar(C0-C6alkyl), Het(C0-C6alkyl), halogen or Hca(C1-C6alkyl)—O—, wherein Ar, Het, Cak, Hca and the alkyl group is optionally substituted by one to four —RX1 groups, whereineach —RX1 is independently halogen, cyano, C1-C6alkyl, C1-C6haloalkyl, —C1-C60alkoxy, oxo, —OR, —SR, —NR2, —C(O)R, —C(O)OR, —C(O)NR2, —S(O)2NR2, —S(O)2R, —OC(O)R, —N(R)C(O)R, —OC(O)OR, —OC(O)NR2, —N(R)C(O)OR, —N(R)C(O)NR2, —N(R)S(O)2R, —OP(O)(OR)2, —CH2—OP(O)(OR), Ar(C0-C6alkyl), Het(C0-C6alkyl), Cak(C0-C6alkyl) or Hca(C0-C6alkyl),
or two —RX1 groups taken together, when attached to adjacent atoms, form a Cak, Hca or Het, wherein the Cak Hca and the Het comprise a 3-8 membered ring optionally substituted with one or two —RX2 groups,
or two —RX1 groups taken together, when attached to the same carbon atom, form a Hca, wherein the Hca comprises a 3-8 membered ring optionally substituted with one or two —RX2 groups,
or two —RX1 groups taken together, when attached to non-adjacent atoms, and combined with X, form a bridged Hca optionally substituted with one or two —RX2 groups,
wherein each —RX2 is independently halogen, cyano, nitro, oxo, —OR, —SR, —NR2, —C(O)OR, —C(O)NR2, —C(O)R, —S(O)R, —S(O)2R, —S(O)OR, —S(O)2OR, —S(O)NR2, —S(O)2NR2, —OC(O)R, —OC(O)OR, —OC(O)NR2, —N(R)C(O)R, —N(R)C(O)OR, —N(R)C(O)NR2, —N(R)S(O)R, —N(R)S(O)2R, C1-C6alkyl, or C1-C6haloalkyl;

Y is Cak(C0-C8alkyl) optionally substituted by one or two —RY1 groups;wherein each —RY1 is independently halogen, cyano, C1-C6alkyl, C1-C6haloalkyl, —C1-C6alkyl, oxo, —OR, —SR, —NR2, N(R)C(NR2)NR2, —C(O)R, —C(O)OR, C(O)NR2, —S(O)2NR2, —S(O)2R, —OC(O)R, —N(R)C(O)R, —OC(O)OR, —OC(O)NR2, —N(R)C(O)OR, —N(R)C(O)NR2, —N(R)S(O)2R, —OP(O)(OR)2 or —CH2—OP(O)(OR);

Z is Cak, optionally substituted by one to three —RZ1 groups;wherein each —RZ1 is independently halogen, cyano, C1-C6alkyl, C1-C6haloalkyl, —C1-C6alkoxy, oxo, —OR, —SR, —NR2, —C(O)R, —C(O)OR, —C(O)NR2, —S(O)2NR2, —S(O)2R, —OC(O)R, —N(R)C(O)R, —OC(O)OR, —OC(O)NR2, —N(R)C(O)OR, —N(R)C(O)NR2, —N(R)S(O)2R, —OP(O)(OR)2 or —CH2—OP(O)(OR); and

each R is independently hydrogen, C1-C6alkyl, C1-C6haloalkyl, Hca(C0-C6alkyl), Cak(C0-C8alkyl), C1-C6alkyl-CN, —CH2C(O)NH2, C1-C6alkyl-OH,
whereinHca is a 3-15 membered ring or ring system comprising at least one ring, 1-4 O, S, or N atoms, provided no O or S is adjacent to another O or S;
Het is a 5-15 membered aromatic ring or ring system comprising at least one ring and 1-4 O, S, or N atoms, provided no O or S is adjacent to another O or S;
Cak is a 3-8 membered non-aromatic carbocyclic ring or ring system, which may be saturated or partially unsaturated; and
Ar is a 6-16 membered aromatic ring or ring system having at least one carbocyclic aromatic ring optionally fused one or more aromatic or non-aromatic rings.



US Pat. No. 11,110,080

SMALL MOLECULE INHIBITORS OF BACTERIAL EFFLUX PUMPS AND METHODS OF USING SAME

The Regents of the Univer...


1. A pharmaceutical composition comprising an effective amount of an efflux pump modulator compound and a pharmaceutically acceptable carrier, wherein the efflux pump modulatory compound has one of the structure:



(EPM30)




(EPM35), or




(EPM43).

US Pat. No. 11,110,079

MEBENDAZOLE POLYMORPH FOR TREATMENT AND PREVENTION OF TUMORS

THE JOHNS HOPKINS UNIVERS...


1. A method of treating a brain tumor in a human subject comprising:administering to the subject a sufficient amount of a pharmaceutical formulation comprising mebendazole wherein at least 90% of the mebendazole in the formulation is polymorph C and the pharmaceutical formulation is granulated.

US Pat. No. 11,110,078

COMPOSITION AND METHOD FOR TREATMENT OF DISEASES ASSOCIATED WITH CENTRAL NERVOUS SYSTEM INFLAMMATION

AMRITA VISHWA VIDYAPEETHA...


1. A method of treating multiple sclerosis by inhibiting GMF-? phosphorylation, comprising administering a therapeutically effective amount of a compound of Formula (I):




or a pharmaceutically acceptable salt thereof, wherein the inhibiting of GMF-? phosphorylation is for treatment of multiple sclerosis and wherein the compound of Formula (I) binds to the active site of Glia Maturation Factor Beta (GMF-?) protein and blocks the Ser83 phosphorylation with a binding efficiency in the range of ?6.5 to ?5.5 kcal/mol.

US Pat. No. 11,110,075

USE OF DAPHNETIN IN IMPROVING FUNCTION OF AORTIC ENDOTHELIAL CELL


1. A method for improving function of an aortic endothelial cell, the method comprising contacting the cell with an effective amount of daphnetin.

US Pat. No. 11,110,055

PHARMACEUTICAL FORMULATIONS OF TROPOMYOSIN RELATED KINASE (TRK) INHIBITORS

Genzyme Corporation, Cam...


1. A method of manufacturing a crystalline form of 3-(3-methoxy-4-((4-methoxybenzyl)oxy)benzyl)-6-(1-methyl-1H-pyrazol-4-yl)-3H-imidazo[4,5-b]pyridin-2-amine comprising:a. Mixing 3-(3-methoxy-4-((4-methoxybenzyl)oxy)benzyl)-6-(1-methyl-1H -pyrazol-4-yl)-3H-imidazo[4,5-b]pyridin-2-amine with a solvent to form a suspension;
b. Stirring the suspension;
c. Collecting the solids in the suspension by filtration; and
d. Drying the solids.

US Pat. No. 11,110,052

3D NAVIGATION OF NANOPARTICLES VIA INDUCTION OF METASTABLE DIAMAGNETIC RESPONSE

THE FLORIDA INTERNATIONAL...


20. A method of three-dimensional navigation of magnetic nanoparticles, the method comprising:introducing low-anisotropy magnetic nanoparticles to a mammal; and
directing the low-anisotropy magnetic nanoparticles towards a target region of the mammal by:subjecting the low-anisotropy magnetic nanoparticles to an alternating signal comprising a uniform magnetic field pulse having a strength greater than a coercivity of the low-anisotropy magnetic nanoparticles and a magnetic gradient pulse having an initial location of a lowest strength at the target region of the mammal,

the direction of the uniform magnetic field pulse being opposite of the direction of magnetic gradient pulse,
adjusting a spin relaxation time of a low-anisotropy magnetic nanoparticle of the low-anisotropy magnetic nanoparticles comprising adjusting a size of the of the low-anisotropy magnetic nanoparticle and a strength of the magnetic gradient pulse,
the low-anisotropy magnetic nanoparticles comprising iron,
a time duration of the uniform magnetic field pulse being equal to a time duration of the magnetic gradient pulse,
the time duration of the uniform magnetic field pulse and the time duration of the magnetic gradient pulse being dependent upon a spin relaxation time at a particular strength of the magnetic gradient pulse,
the method further comprising altering a direction of the low-anisotropy magnetic nanoparticles by adjusting the location of the lowest strength of the magnetic gradient pulse,
the uniform magnetic field pulse and the magnetic gradient pulse being applied by an electromagnet comprising a conductive wire wrapped in a coil,
the conductive wire being wrapped around a magnetic core,
the time duration of the uniform magnetic field pulse being equal to a time duration required for the low-anisotropy magnetic nanoparticles to physically rotate 180 degrees inside the mammal, and
the time duration of the magnetic gradient pulse being equal to the time duration required for the low-anisotropy magnetic nanoparticles to physically rotate 180 degrees inside the mammal.

US Pat. No. 11,110,046

SHAPING KERATIN FIBRES USING 2-HYDROXYPROPANE-1,2,3-TRICARBOXYLIC ACID AND/OR 1,2,3,4-BUTANETETRACARBOXYLIC ACID

The Procter and Gamble Co...


1. A method for straightening curly hair comprising:(a) providing in a package a solid composition, wherein the solid composition comprises:hydrophobically modified alkali soluble acrylic polymer emulsion;
an active agent, wherein the active agent is a mixture of 2-hydroxypropane-1,2,3-tricarboxylic acid and 1,2,3,4-butanetetracarboxylic acid;
a photocatalyst which is a mixture of 8-hydroxyquinoline and 8-quinolinol-1-oxide;

and then mixing the solid composition with a cosmetically acceptable carrier to form a crosslinking composition comprising from about 10% to about 90% water;
wherein the crosslinking composition has a viscosity of from about 1 mPa·s to about 80,000 mPa·s; and then
(b) applying the crosslinking composition comprising from about 5% by weight of active agent, 100 ppm 8-hydroxyquinoline and 100 ppm 8-quinolinol-1-oxide photocatalyst to curly hair, mechanically straightening the hair with a hair straightening iron at a temperature of about 250° F. and exposing the composition to electromagnetic radiation having a wavelength of 380 nm;
wherein the method does not comprise a rinsing step between step (a) and step (b) and wherein the crosslinking composition prepared by the mixing stage of step (a) has not been exposed to said radiation for a period of 10 minutes or more and wherein it is not a requirement that the solid composition of step (a) has not been exposed to said radiation;
and wherein 0.25 g of said crosslinking composition per gram of hair is used in the method.

US Pat. No. 11,110,043

ALKENONE-BASED FORMULATIONS FOR TOPICAL APPLICATIONS

WWU, Bellingham, WA (US)...


1. A personal care composition, comprising:a compound of Formula (I):




wherein
R1 is methyl or ethyl; and
R2 is a C30-45 alkenyl having at least one trans double carbon-carbon bond, or R2 is a C30-45 alkyl;
provided that the compound of Formula (I) is not





wherein the composition does not comprise carotenoids and chlorophylls, and the composition does not comprise a total algae lipid extract or an acylglycerol.

US Pat. No. 11,110,039

MACROMONOMER BASED LIGHT-CURABLE DENTAL IMPRESSION MATERIAL

DENTSPLY SIRONA Inc., Yo...


1. A light-curable dental impression material comprising:(a) a polymerizable polysiloxane resin composition comprising compounds of the following formula (I):E-(L1-Z)n-L2-E ??(I)
wherein
the E which may be the same or different, independently represent a monovalent group selected from a group containing a polymerizable carbon-carbon double bond, a group containing a polysiloxane moiety, a C2-20 alkoxy group, a C2-20 thioalkyl group, and a RNH group, wherein R is a C2-20 alkyl group;
L1 which may be the same or different when more than one L1 is present, represents a divalent group of the following formula (II):







wherein
L3 which may be the same or different when more than one L3 is present, independently represents a divalent linker group which may be substituted with up to four substituents of the formula (III):-L1-E ??(III)
wherein L1 and E are as defined above;

L4 which may be the same or different when more than one L4 is present, independently represents a divalent linker group which may be substituted with up to four substituents of the formula (III), wherein L1 and E are as defined above;
X1, X2, Y1, and Y2,which may be the same or different, and when more than one X1, X2, Y1, or Y2, is present, the X1, X2, Y1, and Y2 may be the same or different, independently represent an oxygen atom, a sulfur atom and a group NR?, wherein R? is a hydrogen atom or a C1-4 alkyl group;

m represents 0 or an integer of from 1 to 40;

Z represents a divalent linker group which may additionally be substituted with up to four substituents selected from polysiloxane groups, groups of the formula (III) and combination thereof, wherein L1 and E are as defined above;
L2 represents a single bond or a divalent group of the formula (II), wherein L3, L4, X1, X2, Y1, Y2 and m are independently as defined for L1;
n represents 0 or an integer of from 1 to 4;
provided thata compound of formula (I) contains at least one monovalent group E having a polymerizable carbon-carbon double bond,
a compound of formula (I) contains at least one polysiloxane group and

provided thatwhen n is 0, then L2 is a divalent group of the formula (II);


(b) a particulate filler; and
(c) a photoinitiator.

US Pat. No. 11,110,038

DENTAL POLYMERIZABLE MONOMERS, COMPOSITIONS, ADHESIVE DENTAL MATERIALS AND KITS

MITSUI CHEMICALS, INC., ...


1. A dental adhesive curable kit (?c) for preparing a dental adhesive curable composition (c), the dental adhesive curable composition (c) comprising a polymerizable monomer (III) comprising a polymerizable monomer (A) represented by the following general formula (1?) and an acidic group-containing polymerizable monomer (Bc), a polymerization initiator (Cc) comprising a peroxide (Cc1) and a photopolymerization initiator (Cc2), and a reductant (Dc) comprising a sulfinic acid compound (Dc2) and/or a salt thereof, and a filler (Fc), whereinthe content of the polymerizable monomer (A) is not less than 0.1 part by weight and not more than 99 parts by weight, and the content of the acidic group-containing polymerizable monomer (Bc) is 0.5 to 30 parts by weight based on the total weight of the polymerizable monomer (III);
the content of the peroxide (Cc1) is 0.01 to 20 parts by weight, the content of the photopolymerization initiator (Cc2) is 0.0001 to 15 parts by weight, and the content of the sulfinic acid compound (Dc2) or salt thereof is 0.001 to 15 parts by weight based on the polymerizable monomer (III); and
the content of the filler (Fc) is 5 to 95 wt % in the dental adhesive curable composition (c):




wherein R1 and R2 are each a hydrogen atom or a C1-3 alkyl group, R7 and R8 are each a hydrogen atom or a methyl group, Rb and Rc are each independently a C2-6 linear alkylene or C2-6 linear oxyalkylene group optionally substituted with a C1-3 alkyl group or a (meth) acryloyloxymethylene group in place of a hydrogen atom, and a moiety of the general formula (2c) below that is interposed between the two carbamoyl groups in the general formula (1?) is a structure represented by any of the general formulas (RA) and (RD) below:





the dental adhesive curable kit (?c) comprising at least a first composition and a second composition,
at least one of the first composition and the second composition including the polymerizable monomer (A),
the first composition including the reductant (Dc),
the second composition including the acidic group-containing polymerizable monomer (Bc) and the polymerization initiator (Cc).


US Pat. No. 11,110,037

METHODS AND COMPOSITIONS TO STABILIZE A NANOGEL AND DENTAL COMPOSITIONS THEREFROM

DENTSPLY SIRONA Inc., Yo...


1. A dental composition comprising a nanogel formed by a process comprising the steps of:(a) polymerizing by a thermal polymerization a mixture comprising(i) at least one comonomer having one ethylenically unsaturated group,
(ii) at least one of a comonomer having two ethylenically unsaturated group and at least one comonomer having at least three ethylenically unsaturated groups,
(iii) at least one chain transfer agent, and
(iv) an initiator;
at a reaction temperature to obtain a nanogel solution; and

(b) terminating the polymerization by lowering the reaction temperature and quenching the nanogel solution with a radical scavenger; wherein the radical scavenger is present at a concentration such that nanogel solution has a thermal stability at storage for 7 days at 25° C.

US Pat. No. 11,110,036

FEEDING SET AND ENTERAL FEEDING PUMP ASSEMBLY

Medline Industries, Inc.,...


1. A feeding set comprising:a dispensing control valve sized for placement at least partially within an enteral feeding pump and configured to releasably engage a first retention portion of the enteral feeding pump, the dispensing control valve having a plunger positioned at least partly therein to selectively control a flow of fluid through the dispensing control valve;
a peristaltic tubing element fluidly connected to an exit of the dispensing control valve, the peristaltic tubing element being elastomeric; and
an attachment mechanism configured to releasably engage a second retention portion of the enteral feeding pump;
wherein the peristaltic tubing element is sized to be placed under tension and for said peristaltic tubing element to be retained with respect to the enteral feeding pump via tension when the dispensing control valve engages the first retention portion of the enteral feeding pump and the attachment mechanism engages the second retention portion of the enteral feeding pump.

US Pat. No. 11,110,035

TACTICAL MEDICINE DISPENSERS

GRAM TACTICAL LLC, Nashv...


1. A portable medicament case comprising:a medicament provided in a package;
first and second housing members that are configured to form a medicament package receiving cavity when joined together, with each housing member including a mating member that is configured for engagement with the other housing member in order to join the first and second housing members together in a sealed configuration that prevents moisture or contaminants from entering into the cavity;
a gasket removably positioned between the first and second housing members to provide a hermetic seal about the medicament package when the housing members are in the mating engagement in the sealed configuration; and
a base member configured to selectively receive the second housing member opposite the first housing member, the base member including a means for connection that forms or is connectable to a rod, strap, belt or clothing article for secure transport of the portable medicament case on or with a person;
wherein one housing member includes an aperture configured to assist in removing the medicament package from that housing member when the housing members are not joined together in the sealed configuration.

US Pat. No. 11,110,034

MEDICINE PILL CUTTER

3 CUT PRO LLC, St. Augus...


11. A method for cutting a medicine pill, comprising:providing and positioning a first rib with indentations and a second rib with indentations to form a triangular slot on a top cover;
providing and positioning a first blade and a second blade arranged as a V-shape on a bottom cover, wherein the V-shape is corresponding to the triangular slot, and the bottom cover and the top cover are attached via a hinge;
providing a triangular insert and a spring, wherein the triangular insert attached to the bottom cover via the spring, and the triangular insert is positioned between the first blade and the second blade;
securing the medicine pill between the first rib and the second rib;
cutting the medicine pill with the blades by closing the top cover and the bottom cover together; and pivoting the top cover away from the bottom cover so that the portion of the cut medicine pill stuck between the blades is ejected by the triangular insert and the spring.

US Pat. No. 11,110,033

INTEGRATED STRUCTURE OF PREPARATION SYRINGE

JIANGNAN UNIVERSITY, Jia...


1. A preparation syringe system, comprising a stretchable piston, a barrel, a needle, an exposed rubber plug, a first sealing sheet, a second sealing sheet, a built-in rubber plug, a sealing rubber plug, and an engaging rubber plug, wherein the stretchable piston, the barrel, the exposed rubber plug, the first sealing sheet, and the built-in rubber plug form an integrated structure,wherein one end of the barrel is provided with the stretchable piston, another end of the barrel is provided with a clamping column, the exposed rubber plug is provided on a side of the stretchable piston away from the barrel, the built-in rubber plug is provided inside the barrel, a scale mark is provided on a circumferential surface of the barrel, the sealing rubber plug is removably inlaid and sleeved on the clamping column, the first sealing sheet is provided on a side of the exposed rubber plug away from the barrel, a blunt end is provided at an end of the needle away from a needle tip, and the engaging rubber plug is provided outside the blunt end,
wherein the second sealing sheet is provided outside the sealing rubber plug, when the second sealing sheet is revealed and the sealing rubber plug is removed from the clamping column of the barrel, the needle is able to be assembled on the integrated structure through the engaging rubber plug.

US Pat. No. 11,110,032

FILLABLE 3D FLEXIBLE POUCH FOR BIOPHARMACEUTICAL FLUIDS, AND METHOD FOR PRODUCING SUCH A POUCH

SARTORIUS STEDIM FMT SAS,...


1. A 3D flexible pouch to be filled with a biopharmaceutical product, the flexible pouch being designed to be deployed from an empty, flat configuration towards a substantially parallelepiped configuration in a filled state, the flexible pouch comprising:a first wall element consisting of a film and defining a front face, the first wall element having two side edges distributed on either side of a longitudinal axis of the pouch in the flat configuration;
a second wall element consisting of a film and defining a rear face, the second wall element having two additional side edges distributed on either side of said longitudinal axis of the pouch in the flat configuration;
a first gusset and a second gusset, each connected to one of said side edges of the first wall element and one of said additional side edges of the second wall element, the first gusset and the second gusset each being constituted by respective films cut out from one piece and each being foldable along a folding line towards the inside which extends between two opposite ends of the flexible pouch;
the longitudinal axis of the flexible pouch extending between the folding line of the first gusset and the folding line of the second gusset in the flat configuration; and
at one of the two opposite ends, the films respectively constituting the first wall element and the second wall element are directly welded to one another, so as to define a join portion common to the side edges which, in the flat configuration, projects axially towards the outside with respect to the first and second gussets and is defined by two oblique edges which are oblique with respect to the longitudinal axis.

US Pat. No. 11,110,031

AIR POCKET-TYPE MASSAGE DEVICE

CERAGEM CO., LTD., Chung...


1. A massage device comprising:a first bed portion comprising a top surface configured to directly support an upper body of a user;
a second bed portion configured to support a lower body of a user, wherein the second bed portion is configured to slide over the top surface of the first bed portion;
a massage module disposed on the second bed portion and comprising a flexible sheath that includes a plurality of air pockets; and
a position adjuster comprising a transfer plate on which the plurality of air pockets are mounted and provided above the first and second bed portions, wherein the position adjuster is configured to change a position of the massage module,
wherein the plurality of air pockets comprise at least:
a first pair of air pockets and a second pair of air pockets disposed at an inner side in the transfer plate; and a third air pocket and fourth air pocket each disposed at a first outer side and an opposite second outer side, respectively, in the transfer plate, wherein each of the third and fourth air pockets have a larger width when compared with each of the first pair of air pockets and second pair of air pockets,
wherein when the first and second pair of air pockets are expanded, portions of the flexible sheath that include the first and second pair of air pockets are configured to come into contact with internal lower points of the calves of the user and to apply forces to the calves upwards from the inner side, and
wherein when the third and fourth air pockets are expanded, portions of the flexible sheath that include the third and fourth air pockets are configured to come into contact with external upper side points of the calves of the user and to apply forces to the calves downwards from the outer side.

US Pat. No. 11,110,030

METHOD OF BODY SCANNING DETECTION FOR ADVANCED ROBOTIC MASSAGE CHAIRS

Luraco, Inc, Arlington, ...


1. A method for scanning a user's body in a massage chair using a roller mechanism and an electronic system, method comprising:driving a roller mechanism along the user's body;
poking on a user's back with a roller as the roller mechanism is moving;
wherein, poking is generated by driving an intensity control motor to cause the roller to move forward and backward;
during a poke, the electronic system records load current of the intensity control motor and distance that the roller traveled;
processing the recorded motor load current data to generate a body shape curve or locate a position of a user's body part, including a shoulder, or neck, or lower back, or mid back, or upper back positions of the user's body;
wherein, the roller mechanism includes a roller motion drive element to hold or support a driving ball bearing, the roller motion drive element having an aperture for a driving shaft to pass through; and
wherein, said driving shaft configured to pass through the roller motion drive element in an offset non-perpendicular angle relative to a driving ball bearing side face.

US Pat. No. 11,110,029

CLAW MASSAGE APPARATUS

XIAMEN SOLEX HIGH-TECH IN...


1. A claw massage apparatus comprising:a drive mechanism, comprising an impeller and an upper cover; the impeller comprises a wheel body and blades disposed on the wheel body, and the wheel body is connected to a transmission mechanism in a transmission way; the upper cover is disposed around the impeller, and is provided with water inlet holes in communication with the impeller; a water flow is able to enter the impeller through the water inlet holes, and flush the blades to rotate the impeller, so as to drive rotation of the transmission mechanism;
the transmission mechanism is configured to be driven by the drive mechanism to rotate, and the transmission mechanism being provided with a moving rail, the transmission mechanism comprising a rail plate that is driven by the drive mechanism to rotate, and the rail plate defines a motion track;
a base to which the transmission mechanism is rotatably connected;
a plurality of massage mechanisms, which are supported by the base, each of the massage mechanisms comprising a connecting part connected to the moving rail in the transmission way and a massage claw positioned outside the base;
wherein the drive mechanism is configured to drive rotation of the moving rail, wherein an outer circumference of the rail plate forms the moving rail; the connecting part of the massage mechanism comprises a connecting body and a first connecting post, and the first connecting post is protruded along an axis at a top of the connecting body; the massage claw comprises a first connecting sleeve and a claw body; the first connecting sleeve is fixed to an upper end of the claw body and is sleeved with the connecting body, and the claw body is positioned outside the base; an outer circumference of the first connecting post is closely attached to the outer circumference of the rail plate, during the rotation of the rail plate, the first connecting post is pushed by the outer circumference of the rail plate to move to drive the respective connecting parts to synchronously swing, so that the respective massage claws are close to or away from each other, such that the respective massage claws move between a first extreme position and a second extreme position; in the first extreme position, the respective massage claws are close to each other; in the second extreme position, the respective massage claws are distanced from each other; and
tension springs, which are disposed on the inner circumference of the base and abut against the first connecting posts, respectively; as the moving rail rotates, the first connecting post gradually approaches to the first position, and gradually compresses the tension springs; when the respective first connecting posts are in the first positions, the tension springs are further compressed, to accumulate an elastic restoring force toward a center of the moving rail for the respective first connecting post.

US Pat. No. 11,110,028

HIGH FREQUENCY CHEST WALL OSCILLATION SYSTEM

HILL-ROM SERVICES PTE. LT...


1. An apparatus to apply high frequency chest wall oscillation (HFCWO) therapy to a thorax of a patient, the apparatus comprisinga garment configured to be worn on the patient's thorax,
a plurality of oscillators coupled to the garment, each oscillator of the plurality of oscillators being configured to be situated over an associated region of a front of the patient's thorax, wherein each oscillator of the plurality of oscillators comprises an inflatable chamber that receives air pulses to produce oscillatory forces against the thorax of the patient by the respective inflatable chamber, and
at least one user input that is usable to adjust at least one operating parameter of at least one oscillator of the plurality of oscillators so that the at least one oscillator operates differently than each of the other oscillators of the plurality of oscillators during delivery of the HFCWO therapy to the patient, wherein the plurality of oscillators comprise a first oscillator configured to be situated over a top portion of the patient's right lung, a second oscillator configured to be situated over a bottom portion of the patient's right lung, a third oscillator configured to be situated over a top portion of the patient's left lung, and a fourth oscillator configured to be situated over a bottom portion of the patient's left lung, and wherein the at least one oscillator comprises at least one of the first oscillator, the second oscillator, the third oscillator, and the fourth oscillator, wherein the at least one user input comprises first, second, third, and fourth user inputs that are separately and individually mounted on the garment and located directly below a respective one of the first oscillator, the second oscillator, the third oscillator, and the fourth oscillator when the patient is wearing the garment having the patient's thorax in an upright position.

US Pat. No. 11,110,027

VISION TRAINING DEVICE FOR IMPROVING FUSIONAL VERGENCE

EDENLUX CORPORATION, Cha...


1. A vision training device, comprising:a first display configured to provide a left eye image corresponding to a left eye of a user;
a second display configured to provide a right eye image corresponding to a right eye of the user; and
a controller configured tocontrol at least one of the first display and the second display to move at least one of the left eye image and the right eye image such that image focuses of the left and right eye images coincide with each other in terms of fusion,
control at least one of the first display and the second display to move at least one of the left eye image and the right eye image such that a distance between the left eye image and the right eye image is increased,
receive a separation confirmation signal indicating that the image focuses do not coincide with each other in terms of fusion, and
store, as fusional amplitude information, information indicating a separation distance between the left eye image and the right eye image when the separation confirmation signal is received.


US Pat. No. 11,110,026

AESTHETIC GLIDER FOR WALKERS

Steven James Ayre, Midla...


1. A method of anchoring a flexible, solid filament to a walking aid, the method comprising:providing an anchoring element, the anchoring element comprising at least one channel extending there through, the channel having a first end and a second end, wherein the channel is larger in size at the first end than the second end;
inserting an end of the filament into the second end of the channel in the anchoring element such that the end of the filament surpasses the first end of the channel;
bending the flexible, solid filament adjacent itself;
drawing the bent filament into channel tightly; and
attaching the anchoring element to the walking aid.

US Pat. No. 11,110,025

WEARABLE ROBOTIC DEVICE

Parker-Hannifin Corporati...


1. A wearable robotic device comprising:a removable, self-contained actuator cassette; and
a thigh assembly including a receptacle for receiving and retaining the removable, self-contained actuator cassette, wherein the removable, self-contained actuator cassette is removable from the receptacle as a unit;
wherein the removable, self-contained actuator cassette comprises:a motor;
a drivetrain operatively coupled to and driven by the motor;
a housing supporting the motor and drivetrain; and
a connector protruding from and rotatable with respect to the housing and driven by the drivetrain;
wherein:
the housing comprises a top plate on which the motor is mounted and a bottom plate coupled to the top plate, and a drive shaft of the motor protrudes through an offset portion of the top plate;
the drivetrain is sandwiched between the top plate and the bottom plate;
the motor is mounted outside the top and bottom plates; and
the motor and the drivetrain are fixed to the housing to form the removable, self-contained actuator cassette that is removable as the unit relative to the receptacle of the thigh assembly.


US Pat. No. 11,110,024

WEARABLE ASSIST ROBOT APPARATUS

POWER ASSIST INTERNATIONA...


1. A wearable assist robot apparatus, comprising:a harness device to be worn and retained by a wearer;
an assist drive mechanism provided on the harness device, including a left drive source configured to be disposed on a left side of a lower body trunk of the wearer and a right drive source configured to be disposed on a right side of the lower body trunk of the wearer, and the left drive source and the right drive source configured to generate drive torque about an axial line in a lateral direction of the wearer, the assist drive mechanism being configured to apply assisting force moments respectively to portions of the wearer between a body trunk and respective left and right thighs by drive torque from the left and right drive sources;
at least one angle sensor at each of the left and right drive sources and configured to detect relative angles between the body trunk and the respective left and right thighs of the wearer about the axial line in the lateral direction;
an acceleration sensor provided on the harness device, the acceleration sensor being configured to detect an acceleration of the body trunk;
at least one processor configured to
determine a foot landing state in response to an output from the acceleration sensor; and
in response to outputs from respective angle sensors and a determined foot landing state, apply an assisting force moment in a direction of support to a supporting leg in a landed state by a supporting-leg side drive source of the left and right drive sources, and apply a swing-up force moment in a swing-up direction to a free leg not in contact with land by a free-leg side drive source of the left and right drive sources,
wherein, based on a local maximum value of acceleration in a vertical direction of the body trunk which value is detected by the acceleration sensor, the at least one processor determines that one of feet lands; and at least one object sensor configured to be mounted on a hand of the wearer, the at least one object sensor being configured to detect an action of an object on the hand, wherein the at least one processor applies a lifting force moment in a lifting direction in which the relative angles between the body trunk and the respective thighs increases by the left and right drive sources when an object is detected, in response to outputs from the at least one angle sensor at each of the left and right drive sources and the at least one object sensor.

US Pat. No. 11,110,023

CHAIR WITH SWIVEL AND BRAKE SYSTEM

Boyd Industries, Inc., C...


1. A chair comprising:a seat;
a leg rest;
a brake and swivel system;
a lift;
at least one electric screw drive motor housed within the lift,wherein the electric screw drive motor can adjust the height of the chair,
further wherein the height of the chair can be adjusted to at least about 21.75 inches from the ground to the underside of the seat; and

a seatback,wherein the pitch of the seatback can be adjusted to a position parallel to the ground.


US Pat. No. 11,110,022

PATIENT POSITIONING SUPPORT STRUCTURE WITH TRUNK TRANSLATOR

WARSAW ORTHOPEDIC, INC, ...


1. A patient support structure comprising:a first base;
a second base;
a patient support comprising a head section coupled to the first base and a foot section coupled to the second base, the sections each including a bottom surface and an opposite top surface configured to support a patient, the top surface of the head section defining a first plane, the top surface of the foot section defining a second plane; and
a tilt assembly coupled to one of the bases and one of the sections, the tilt assembly being configured to move the patient support between a first orientation in which the first plane extends parallel to the second plane and a second orientation in which the first plane extends transverse to the second plane.

US Pat. No. 11,110,021

MEDICAL PRESSURE THERAPY DEVICE AND COMPONENTS THEREOF

OTIVIO AS, Oslo (NO)


1. A pressure therapy device, comprising:a pressure chamber having first and second ends, the first end defining an opening;
an inflatable padding positioned in the opening, the inflatable padding comprising at least two air chambers formed from a continuous material; and
a seal secured to the first end of the pressure chamber for sealing against a limb of a user in the opening;
wherein the inflatable padding is configured to be inflatable to narrow the opening and secure about the limb of a user.

US Pat. No. 11,110,020

SMART HOSPITAL HEADWALL SYSTEM

Stryker Corporation, Kal...


1. A stationary communication unit adapted to be mounted in a room of a healthcare facility, the stationary communication unit comprising:a first transceiver adapted to communicate with a patient support apparatus and receive a request to communicate with a caregiver when the caregiver is remotely located, the request initiated by a patient supported on the patient support apparatus;
a second transceiver in communication with a nurse call system port, the nurse call system port installed on a wall of the room; and
a controller adapted to forward the request to the nurse call system port via the second transceiver, the controller also adapted to receive data via the first transceiver from a medical device positioned in the room and to store the data in a memory onboard the stationary communication unit for retrieval by authorized individuals, the medical device being different from the patient support apparatus, wherein the data is communicated to the first transceiver from the patient support apparatus after the patient support apparatus receives the data from the medical device via a third transceiver positioned on the patient support apparatus.

US Pat. No. 11,110,019

CONNECTING ELEMENT FOR MEDICAL BEDRAIL, ASSEMBLY COMPRISING IT AND PROCEDURE FOR ASSEMBLING SAID ASSEMBLY

NOVAK M D.O.O, Komenda (...


1. A connecting element for a medical bedrail:wherein the connecting element connects a connecting rod and a pivotable rod of a foldable bedrail for medical beds, including at least one of stretchers, beds and gurneys, the foldable bedrail having at least two positions, namely a folded position and a deployed position, wherein the connecting element comprises:
a jaw, an inner surface of the jaw being concave in shape and adapted for abutting tightly against an outer surface of the connecting rod,
two locking teeth fashioned symmetrically on or at an upper edge of the inner surface of the jaw, each on one side of the jaw, respectively, and adapted for co-operating with locking slots fashioned in the connecting rod, and
two legs fashioned on an upper part of an outer side of the jaw and arranged symmetrically with respect to a central plane (R) extending vertically and longitudinally through a center of the jaw, each of the two legs comprising a snap-fit element fashioned on an inner surface of one of the two legs facing an inner surface of another of the two legs, the snap-fit elements being arranged symmetrically with respect to the central plane (R) and co-operating with two snap-fit openings fashioned in the pivotable rod, the snap-fit elements and the corresponding snap-fit openings being fashioned to allow the pivotable rod to be rotated in the central plane (R).

US Pat. No. 11,110,018

BED LIFT SYSTEM AND METHODS OF MAKING AND USING THE SAME

Principle Long Term Care ...


1. A lift system comprising:a support configured to maintain a bed frame thereon, the support defined by:a first swing arm opposing a second swing arm;
a pivoting plate opposing an end plate;
wherein first ends of the swing arms are configured to swing outward about ends of the pivoting plate, wherein second ends of the swing arms are configured to removably attach to the end plate to form a rectangular structure for securely receiving a bed frame,
wherein the end plate detaches from the swing arms and the swing arms pivotally swing outwards about the ends of the pivoting plate to release the bed frame;

a storage unit defined by:a lift gate configured within an interior of the storage unit, the lift gate including a linear actuator for converting the support between a folded and an unfolded position by manipulating the pivoting plate coupled to the linear actuator;
one or more front doors that can be maneuvered to the interior of the storage unit; and
a controller for controlling the lift gate, wherein the lift gate is unlocked to allow the support to be lifted into the interior of the storage unit after the end plate is attached to the swing arms.


US Pat. No. 11,110,017

RECLINING ARMCHAIR WITH LIFTING SEAT AND EXTENDING FOOTREST


1. An armchair comprising:a seat chassis supported on a support chassis by a pair of support columns;
a chair back structure attached to a rear end of the seat chassis and to the support chassis;
a leg support structure pivotally attached to a front end of the seat chassis and connected to a beam, wherein the beam is attached to the chair back structure; and
a seating structure connected to a first actuating device and mounted above the seat chassis; and
a control device that controls the first actuating device in lifting and pivoting the seating structure into an upright position towards the front end of the seat chassis, wherein the control device further controls at least a second actuating device that reclines the seat chassis, reclines the chair back structure, and raises the leg support structure.

US Pat. No. 11,110,016

DRIFTING KART


1. A ridable vehicle comprising:a chassis;
a steering assembly comprising a steering wheel and a steering column;
a seat;
a front wheel;
a plurality of rear caster wheels, wherein each of the plurality of rear caster wheels is configured to rotate about a respective rotational axis and swivel about a respective swivel axis;
a motor configured to drive the front wheel; and
a hand lever configured to move between a raised position and a lowered position;
wherein the plurality of rear caster wheels are configured to move between a first position and a second position;
wherein when the hand lever is in the raised position, the plurality of rear caster wheels are in the first position; and
wherein when the hand lever is in the lowered position, the plurality of rear caster wheels are in the second position.

US Pat. No. 11,110,015

ARRAY OF DISPOSABLE ABSORBENT ARTICLES HAVING A SEQUENCE OF GRAPHICS CORRESPONDING TO A WEARER'S STAGES OF DEVELOPMENT


1. An array of disposable absorbent articles, the array comprising:a first absorbent article in a first package, wherein an externally visible outer garment facing portion of the first absorbent article comprises a dye or pigment, and wherein the first absorbent article is a first size;
a second absorbent article in a second package, wherein an externally visible outer garment facing portion of the second absorbent article comprises a dye or pigment, and wherein the second absorbent article is a second size;
a third absorbent article in a third package, wherein an externally visible outer garment facing portion of the third absorbent article comprises a dye or pigment, and wherein the third absorbent article is a third size;
wherein the second absorbent article comprises a greater percentage of the dye or pigment of the outer garment facing surface portion of the second absorbent article versus a percentage of the dye or pigment of the outer garment facing surface portion of the first absorbent article;
wherein the third absorbent article comprises a greater percentage of the dye or pigment of the outer garment facing surface portion of the third absorbent article versus the percentage of the dye or pigment of the outer garment facing surface portion of the first absorbent article;
wherein the second size of the second absorbent article is greater than the first size of the first absorbent article, and wherein the third size of the third absorbent article is greater than the second size of the second absorbent article.

US Pat. No. 11,110,014

ABSORBENT CORE COMPRISING A HIGH LOFT CENTRAL LAYER AND CHANNELS


1. An absorbent core for use in an absorbent article, the absorbent core extending in a transversal direction and a longitudinal direction, the absorbent core comprising:a fluid-permeable top layer;
a bottom layer;
a central layer sandwiched between the top layer and the bottom layer, the central layer having a front edge, a back edge and two longitudinally extending side edges, wherein the central layer is a high loft fibrous nonwoven layer comprising synthetic fibers, the synthetic fibers comprising polypropylene (PP) fibers; and
superabsorbent polymer particles blended with the synthetic fibers of the central layer and wherein the central layer has a density of about 0.200 g/cc or less, measured at a pressure of 4.14 kPa;
wherein the central layer comprises one, two or more longitudinally-extending channels substantially free of superabsorbent polymer particles.

US Pat. No. 11,110,013

NONWOVEN WEBS WITH HYDROPHOBIC AND HYDROPHILIC LAYERS


1. A nonwoven web for use in absorbent articles, the nonwoven web comprising:a first nonwoven layer comprising a first plurality of fibers, a first side and a second side opposed to the first side, wherein the second side comprises a plurality of discontinuities, wherein the first nonwoven layer comprises a hydrophobic additive, wherein the hydrophobic additive is in the form of fibrils extending outwardly from a surface of the first plurality of fibers, wherein the fibrils have a color which is different than that of the first plurality of fibers; and
a second nonwoven layer comprising a second plurality of fibers, a first surface and a second surface opposed to the first surface and a plurality of tufts extending through at least a portion of the discontinuities in the first nonwoven layer and above the first side of the first nonwoven layer, wherein the second nonwoven layer is attached to the first nonwoven such that at least a portion of the second plurality of fibers are in liquid communication with the first nonwoven layer, wherein the first woven layer is hydrophobic and the second nonwoven layer is hydrophilic.

US Pat. No. 11,110,012

DISPOSABLE ABSORBENT ARTICLE WITH PROFILED ABSORBENT CORE

DSG Technology Holdings L...


1. A disposable absorbent article comprising:an absorbent core, the absorbent core including an absorbent core element and elastic elements attached to the absorbent core element, the elastic elements extending generally laterally between side margins of the absorbent core element and spaced apart;
wherein the absorbent core further comprises a second absorbent core element, and wherein the elastic elements are disposed between and attached to said absorbent core element and the second absorbent core element;
wherein said absorbent core elements are bonded to the elastic elements at spaced-apart bonding locations along a lateral extent of the elastic elements, wherein the bonding locations are formed by longitudinally extending bonding strips that extend across the laterally extending elastic elements;
wherein, between said spaced-apart bonding locations along said lateral extent of the elastic elements, said absorbent core elements are un-bonded; and
wherein said absorbent core is laterally contracted in a narrowed region about the elastic elements, and wherein the absorbent core has a shape that includes a pair of end regions that are non-elasticized and have a lateral width wider than a lateral width of the narrowed region.

US Pat. No. 11,110,011

ABSORBENT STRUCTURE FOR ABSORBENT ARTICLES


1. An absorbent structure, comprising:a supporting sheet and an absorbent layer of absorbent material comprising a superabsorbent polymer material, said absorbent layer being supported by and immobilized on said supporting sheet; and
said absorbent layer having:a transverse dimension and an average width W, a longitudinal dimension and average length L, and a height dimension;
a first longitudinally extending side portion on one side of a longitudinal axis and a second longitudinally extending side portions on the other side of the longitudinal axis;
a front region, back region and therein between a crotch region, each arranged sequentially in said longitudinal dimension; and
at least a first continuous, substantially longitudinally extending channel and a second continuous, substantially longitudinally extending channel that are substantially free of said superabsorbent polymer material and extending through the height of said absorbent layer, said first channel being present in said first side portion's front region only and said second channel being present in said second side portion's front region only, and

a further channel, wherein the further channel is at least present in the crotch region.

US Pat. No. 11,110,010

WOUND DRESSING


1. An apparatus for the treatment of a wound by applying negative pressure to the wound, the apparatus comprising:a wound contact layer comprising a plurality of fluid passages through the wound contact layer that allow for fluid to pass there through, wherein the wound contact layer is configured to be in contact with the wound and adhere to skin around the wound;
a porous layer above the wound contact layer;
a first flexible layer above the porous layer comprising a flexible film, wherein the first flexible layer comprises an orifice;
a pump comprising a pump inlet and a pump outlet, wherein the pump inlet is configured to be in a facing relationship with the orifice in the first flexible layer to provide a fluid flow path through the orifice directly into the pump inlet to apply negative pressure to the wound through the porous layer and the wound contact layer and configured to draw fluid from the wound into the porous layer; and
a second flexible layer comprising a flexible film, wherein the second flexible layer is sealed to the first flexible layer to form a chamber enclosing the pump.

US Pat. No. 11,110,009

WELDING HELMET FOR DETECTING ARC DATA

ILLINOIS TOOL WORKS INC.,...


1. A welding helmet, comprising:a first sensor disposed on the welding helmet and configured to detect one or more welding arcs that occur during one or more welding operations, wherein the first sensor is an optical sensor;
a second sensor disposed on the welding helmet, wherein the second sensor comprises at least one of an electromagnetic sensor configured to detect electromagnetic emissions in a non-optical wavelength range, a position sensor, an orientation sensor, a motion sensor, a location sensor, a temperature sensor, a humidity sensor, or a sound level sensor;
control circuitry configured to:lighten or darken a lens assembly of the welding helmet based at least in part on the one or more welding arcs detected by the first sensor;
determine whether any of the one or more welding arcs detected by the first sensor are false detections based on the second sensor; and
count a number of the one or more welding arcs detected by the first sensor without including arcs identified as false detections; and

a storage device configured to store the number of the one or more welding arcs.

US Pat. No. 11,110,008

INTRAOCULAR DEVICE FOR DUAL INCISIONS

THE REGENTS OF THE UNIVER...


1. A device for incising a trabecular meshwork, the device comprising:a shaft;
a distal member positioned at a distal end of the shaft, the distal member having a forward end and a rearward end;
a tip disposed at the forward end of the distal member, the tip comprising:a foremost portion having a vertical face; and
right and left angled portions extending from opposing sides of the vertical face;

a right edge and a left edge extending towards the rearward end from the right and left angled portions of the tip, wherein the right edge and the left edge increase in height as they extend rearward; and
a gap rearward of the tip and between the right edge and the left edge,
wherein at least portions of the right and left edges are configured to cut trabecular meshwork tissue as the trabecular meshwork tissue advances in a rearward direction over the right and left edges,
wherein as the trabecular meshwork tissue advances over the right and left edges, an incline of the right and left edges is configured to cause the trabecular meshwork tissue to be lifted away from a back wall of a Schlemm's canal, and
wherein a width between the right and left angled portions of the tip increases as they extend rearward while not exceeding a width between the right and left edges defining the gap.

US Pat. No. 11,110,005

MEDICAL INSTRUMENT WITH AN INTEGRATED OPTICAL FIBER

Alcon Inc., Fribourg (CH...


1. An illuminated microsurgical instrument system comprising:a microsurgical instrument having a distally projecting tubular member arranged to perform a medical procedure at an interventional site, the tubular member having a distal tip and an outer surface;
a sheath member surrounding a portion of the tubular member and extending toward the distal tip of the tubular member; and
an optical fiber extending along a length of the outer surface of the tubular member between the tubular member and the sheath member, wherein at least a portion of the outer surface of the tubular member and at least a portion of an inner surface of the sheath member are sealed together such that the tubular member and sheath member are fixed relative to each other; wherein a tip of the optical fiber is directed toward the distal tip of the tubular member;
wherein the sheath member further comprises an opening in a sidewall of the sheath member, the opening being located adjacent to an air gap between the tubular member and the sheath member, proximal to a distal edge of the sheath member, and circumferentially away from the tip of the optical fiber, wherein the opening is adapted to direct air exiting the air gap away from the optical fiber.

US Pat. No. 11,110,003

GLAND OR DUCT DIAGNOSTIC AND TREATMENT METHODS AND RELATED APPARATUS

MGD Innovations, Inc., T...


1. A device for treating a gland or duct of a patient comprising:a probe having an unsharpened elongated distal end with an outer diameter of approximately 150 ?m or less and a length of approximately 6 mm or less;
wherein the probe has a longitudinal lumen extending therealong defined by a probe wall and a distal hole through the probe wall in fluid communication with the lumen, the distal hole positioned in the probe distal end;
wherein the elongated distal end is stainless steel; and
wherein the outer diameter of the elongated distal end is less than that of an adjacent portion of a remainder of the probe to which the elongated distal end is attached.

US Pat. No. 11,110,002

DEVICE FOR FACILITATING INTRODUCTION OF MEDICINAL DROPS INTO THE EYES AND METHODS OF USE


1. An eye drop guide comprising:a frame including at least one eye-covering member; and
a plurality of apertures arranged in columns, each column having multiple apertures, the apertures in each column being vertically offset from apertures in adjacent columns and apertures in a selected column being in communication with other apertures in the selected column.

US Pat. No. 11,110,001

EXPANDABLE DRUG DELIVERY DEVICES AND METHODS OF USE

ForSight Vision4, Inc., ...


1. A drug delivery device configured to be at least partially implanted in an eye, the device comprising:a retention structure positioned near a proximal end region of the device;
a porous drug release element positioned in fluid communication with an outlet of the device;
an elongated core element having a longitudinal axis; and
a reservoir formed of a non-compliant material positioned around the elongated core element, the reservoir having a volume configured to contain one or more therapeutic agents and to be in fluid communication with the outlet through the porous drug release element,
wherein the device is configured to be at least partially inserted into the eye, and
wherein the reservoir is configured to enlarge in a non-distensible manner from an insertion configuration having a first three-dimensional shape to a deployed configuration having a second three-dimensional shape, such that the second three-dimensional shape is eccentrically positioned relative to the longitudinal axis of the elongated core element.

US Pat. No. 11,110,000

SPRAY EJECTOR MECHANISMS AND DEVICES PROVIDING CHARGE ISOLATION AND CONTROLLABLE DROPLET CHARGE, AND LOW DOSAGE VOLUME OPHTHALMIC ADMINISTRATION

EYENOVIA, INC., Tampa, F...


1. A charge isolated ejector mechanism for generating droplets of a fluid comprising:a flexible printed circuit comprising a laminate structure including:(a) a generator plate having a fluid entrance side, a droplet exit side, and a plurality of openings formed through its thickness;
(b) a piezoelectric actuator operable to directly or indirectly oscillate the generator plate upon application of a voltage;
(c) a first conducting layer having a top surface opposite a bottom surface;
(d) a dielectric layer having a top surface opposite a bottom surface; and
(e) a second conducting layer having a top surface opposite a bottom surface;

wherein:
at least a portion of the top surface of the first conducting layer faces the piezoelectric actuator and at least a portion of the bottom surface of the first conducting layer faces at least a portion of the top surface of the dielectric layer to separate the piezoelectric actuator from the dielectric layer;
at least a portion of the bottom surface of the dielectric layer faces the top surface of the second conducting layer to separate the first conducting layer from the second conducting layer; and
at least a portion of the bottom surface of the second conducting layer faces the fluid entrance side of the generator plate to separate the dielectric layer from the generator plate;
thereby charge isolating and grounding the generator plate.

US Pat. No. 11,109,999

DEVICE FOR REMOVING HEAT, ENERGY, AND/OR FLUID FROM A LIVING MAMMAL

COOLTECH, LLC, Baltimore...


1. A device for inducing evaporation of a fluid from a bodily fluid-containing space in a mammal, the device comprising, in an integrated unit:an air delivery subassembly comprising:an air inlet,
an air outlet,
an air flow path connecting said air inlet and said air outlet,
an air inlet sensor configured to measure air temperature or pressure or both;
a blower situated in said air flow path and configured to draw ambient air from said air inlet and force said ambient air through said air flow path and out said air outlet,
a desiccant chamber situated in said air flow path and configured to receive a desiccant element;
a heat sink situated in said air flow path and configured to remove heat added to air in said air flow path during removal of moisture from said air by said desiccant element;
an air outlet sensor configured to measure air temperature or pressure or both;

a liquid delivery subassembly comprising:a liquid pump, configured to interface with a liquid supply tube and to force liquid to be drawn into said liquid supply tube from a liquid source and out an outlet of said liquid supply tube;

wherein said air delivery subassembly and said liquid delivery subassembly maintain isolation between said air flow path and said liquid supply tube so that air in said air flow path and liquid in said liquid supply tube do not come into contact at any time prior to delivery to said mammal,

wherein at least a portion of said liquid supply tube is attached to a manifold cartridge, and wherein said liquid pump defines an interface configured to receive and engage said manifold cartridge for alignment of said liquid supply tube with said liquid pump.

US Pat. No. 11,109,998

METHOD AND APPARATUS FOR VACUUM-FORMED DENTAL APPLIANCE


1. An oral appliance comprising:an upper tray and a lower tray adapted to fit tightly but removably over one or more occlusal surfaces of respective upper and lower teeth of a patient;
a first set of retention hooks encased by the upper tray, wherein encasing the first set of retention hooks occurs via vacuum forming over a model of a patient's upper teeth that includes the first set of retention hooks formerly attached to the model of the patient's upper teeth;
a set of bite pads integrated with a second set of retention hooks encased by the lower tray, wherein encasing the set of bite pads integrated with the second set of retention hooks occurs via vacuum forming over a model of a patient's lower teeth that includes the first set of retention hooks formerly attached to the model of the patient's lower teeth, the set of bite pads configured to form a bite plane on the one or more occlusal surfaces of the lower tray, each bite pad of the set of bite pad having a bite surface which protrudes therefrom so as to engage one or more occlusal surfaces on the upper tray and thus maintain the one or more occlusal surfaces of the upper and lower trays in a predetermined spaced relation, when the trays are fitted on the patient and a pair of elastic bands couple the upper tray to the lower tray via the first set of retention hooks and the second set of retention hooks to enable a lower jaw of the patient wherein the set of bite pads integrated with a second set of retention hooks encased by the lower tray are adapted to enable one or more extensions to be attached to each bite pad of the set of bite pads to advance forwardly.

US Pat. No. 11,109,997

OSTOMY DEVICE


1. An adaptable ostomy base plate comprising:a film;
a first adhesive deposited on the film and a second adhesive deposited on the first adhesive, with the second adhesive adapted to adhere to skin around a stoma;
a stoma-receiving through-going hole formed through the film and the first adhesive and the second adhesive, with the adaptable ostomy base plate having a first section surrounded by a second section, with the first section extending in a radial direction from an inner boundary defined by the stoma-receiving through-going hole to the second section, and the second section extending in the radial direction from the first section to an outer boundary of the adaptable ostomy base plate; and
a reinforcement ring connected to a distal surface of the film at a radial location between the inner boundary and the outer boundary of the adaptable ostomy base plate;
wherein a portion of the first section of the adaptable ostomy base plate comprises a series of concentric undulations, where the series concentric undulation is formed in the first adhesive as a series of valleys of relatively lower adhesive thickness and ridges of relatively higher adhesive thickness, with the first adhesive formed to follow the series concentric undulations in the film.

US Pat. No. 11,109,995

SHOULDER SUPPORT SYSTEM

DeRoyal Industries, Inc.,...


1. A shoulder support system, comprising:an arm support configured for supporting an arm of a user;
a shoulder strap being convertible between a loop configuration in which the shoulder strap is adapted to encircle a shoulder of the user so as to extend above the shoulder and under an arm pit of the user, and a straight configuration in which the shoulder strap is adapted to extend above and overlie the shoulder of the user;
a front strap connectable between the convertible shoulder strap and a front of the arm support; and
a rear strap connectable between the convertible shoulder strap and a rear of the arm support.

US Pat. No. 11,109,994

DEVICE FOR THE TREATMENT OF MEDIAL TIBIAL STRESS SYNDROME AND OTHER CONDITIONS OF THE LOWER LEG


13. A calf brace for treatment of lower leg conditions of a wearer of the calf brace, the calf brace including:(A) a first strap adapted to be affixed around an upper portion of the wearer's calf;
(B) a second strap adapted to be affixed around a generally central portion of the wearer's calf;
(C) a torsional strap connecting the first and second straps which in use will apply a torsional force to the wearer's calf;
(D) a third strap adapted to be affixed around a lower portion of the wearer's calf;
(E) a generally longitudinal strap connecting the second and third straps;
(F) an elongate compression member held by the longitudinal strap; and
(G) at least one pressure node which in use is located between a strap one of the straps and the wearer's calf so as to apply at a distinct point an elevated pressure at that point to the wearer's calf, said elevated pressure being maintained by the tightness of the strap around the wearer's calf.

US Pat. No. 11,109,993

ORTHOPEDIC WALKING BOOT HAVING A MECHANICALLY ADJUSTABLE RAMP INSERT

DJO, LLC, Vista, CA (US)...


1. An orthopedic walking boot, comprising:a housing configured to encompass at least a user's foot;
a mechanically adjustable ramp insert disposed in the housing and comprising:a ramp surface,
a base,
a threaded shaft secured to an adjusting mechanism at a first end and configured to rotate with the adjusting mechanism,
a first slider nut comprising internal threads, the first slider nut configured to move along the threaded shaft as the threaded shaft is rotated,
a bracket in physical contact with the ramp surface,
a first support coupled to the first slider nut at a first end and to the bracket at a second end, and
a second support coupled to the base at a first end and to the bracket at a second end, wherein the first end of the first support is configured to move toward the first end of the second support, thereby causing mechanically adjustable ramp insert to elevate the ramp surface; and

the adjusting mechanism configured to adjust an elevation angle of the ramp surface.

US Pat. No. 11,109,991

ADJUSTABLE KNEE BRACE


1. A brace wearable on an extremity of a wearer, the extremity having a joint, the brace comprising:a first cuff placeable on the extremity;
an articulation assembly connected with the first cuff, wherein the first cuff is movable with respect to the articulation assembly about a first location defining a first pivot axis between the first cuff and articulation assembly, and wherein the first cuff is movable with respect to the articulation assembly about a second location defining a first rotation axis between the first cuff and articulation assembly, wherein the first pivot axis and the first rotation axis intersect each other;
wherein the articulation assembly further comprises:
a base;
a mount connected to the base at the first location, and connected to the first cuff at the second location; and
an adjuster manipulable to cause the first cuff to pivot about the first pivot axis; and
wherein the first cuff further comprises a second part defining a first plane, and wherein the base defines a second plane, and wherein the first rotation axis intersects the first plane at a fixed angle, and the second plane at a variable angle.

US Pat. No. 11,109,990

CATHETER DELIVERY DEVICE

C. R. Bard, Inc., Frankl...


1. A catheter delivery device for a self-expanding stent, comprising:a distal catheter component carrying the stent;
a distal sheath disposed over the distal catheter component and the stent in an insertion position, wherein relative movement of the distal sheath with respect to the distal catheter component and the stent releases the stent;
a compound catheter portion coupled to the distal catheter component, the compound catheter portion having a stiffness greater than a stiffness of the distal catheter component;
a proximal catheter component having a proximal end attached to a hub and a distal end coupled to the compound catheter portion, wherein:the proximal catheter component, the compound catheter portion, and the distal catheter component together define a contiguous guidewire lumen from a proximal end of the device to a distal end of the device, and
the proximal catheter component surrounds a tube and a pull wire within a lumen of the tube, the pull wire operably connected to the distal sheath via a diving sheath; and

a casing tube surrounding the proximal catheter component, the casing tube telescopically receiving the diving sheath upon proximal movement of the pull wire.

US Pat. No. 11,109,988

SYSTEMS AND METHODS FOR MAKING ENCAPSULATED HOURGLASS SHAPED STENTS

V-Wave Ltd., Caesarea (I...


1. A method for making an encapsulated stent-graft, the method comprising:providing a mandrel comprising a first conical region having a first apex and a second conical region having a second apex, wherein the first conical region and the second conical region are asymmetric and the first conical region and the second conical region are aligned so that the first and second apexes form a substantially V-shaped profile;
placing an expandable stent having an hourglass shape in an expanded form on the mandrel so that a first flared end region of the expandable stent conforms to the first conical region and a second flared end region of the expandable stent conforms to the second conical region;
associating a biocompatible material with the expandable stent to form a stent-graft assembly; and
compressing the stent-graft assembly against the mandrel to form the encapsulated stent-graft; wherein the mandrel comprises a first half having a neck region that extends from the first apex and a second half having the second apex couple to the neck region of the first half.

US Pat. No. 11,109,987

VACUUM DEVICE FOR A PROSTHETIC

Anclote Manufacturing Com...


1. A device to create an elevated vacuum in a prosthetic socket, the device comprising:a body secured to the distal end of the prosthetic socket, the body and the prosthetic socket forming a cavity to receive a residual limb, and the body having a top surface, an inner chamber, an intake port, and an exhaust port;
a manually-operated pump mechanism removably attached to the body and having a piston, a housing, and a biasing member, the piston reciprocating within the housing to create a predetermined level of vacuum in the prosthetic socket;
an opening of the intake port on the top surface of the body is in fluid communication between the cavity and the inner chamber; and
an opening of the exhaust port on the piston is in fluid communication between the inner chamber and atmosphere;
whereby movement of the piston in a first direction expels air from the inner chamber to atmosphere through the exhaust port and movement of the piston in a second direction pulls air from the cavity into the inner chamber through the intake port creating an elevated vacuum in the cavity.

US Pat. No. 11,109,986

TORQUE MEASURING SPRING FOR A PROSTHETIC DRIVE

Otto Bock Healthcare LP, ...


1. A prosthetic, orthotic, or exoskeletal (POE) device comprising:a first member;
a second member moveably connected to the first member through a rotatable joint configured to augment or replace a human joint, the joint applying a torque to the POE device during at least a part of its rotation; and
a spring member fixed to the first member, the second member directly contacting the spring member during at least a portion of the movement of the second member with respect to the first member, the spring member configured to deflect from a neutral position when contacted by the second member and providing resistance to the rotation of the second member in relation to an amount of the torque.

US Pat. No. 11,109,984

TOOL AND METHOD FOR SEPARATING A FEMORAL CUP FROM AN ACETABULAR BALL IN AN IMPLANTED HIP PROSTHESIS


1. A surgical tool configured to separate a femoral cup upon a femoral stem from an acetabular ball engaging the femoral cup, the acetabular ball mounted upon a stem affixed to a concave surface of an acetabular cup having a circumferential edge, the stem extending outwardly from an interior of said acetabular cup of a hip prothesis, the surgical tool comprising:a first handle and a second handle connected by a single fulcrum pin in a hinged rotational relationship about the single fulcrum pin in a rotational plane perpendicular to an axis of the single fulcrum pin, the first and second handles being urged apart by a spring, each handle having a proximal end and a distal end;
the first handle having a femoral engagement component at its distal end thereof, the femoral engagement component having a generally flat, U-shaped plate configuration having a pair of side legs joined at a base connecting the femoral engagement component to the distal end of the first handle, and wherein the U-shaped plate is within a first plane; and
the second handle having an acetabular engagement element at its distal end thereof, the acetabular engagement element is an acetabular engagement component having a generally flat, U-shaped plate configuration having a pair of side legs joined at a base connecting the acetabular engagement component to the distal end of the second handle, and wherein the U-shaped plate of the acetabular engagement component is within a second plane,
the femoral engagement component being sized to engage a neck of a femoral cup, engage an outer hemispherical surface of the femoral cup, engage both the neck and the outer hemispherical surface of the femoral cup, or engage a proximal end of a femoral stem, and
the acetabular engagement element being sized to engage at least a part of the circumferential edge of the acetabular cup,
wherein the second plane of the acetabular engagement element forms a first angle with the first plane of the femoral engagement component when the surgical tool is in a first configuration when the proximal ends of the first and second handles are spaced apart at a maximum distance, and when the surgical tool is in a second configuration and the proximal ends of the first and second handles are at a lesser spaced apart distance than in the first configuration, the second plane of the acetabular engagement element forms a second angle with the first plane of the femoral engagement component, wherein the second angle is greater than the first angle.

US Pat. No. 11,109,983

STEERABLE TLIF SPINE IMPLANT, INSTALLER, AND METHOD OF INSTALLATION

LIFE SPINE, INC., Huntle...


1. A spine implant for a TLIF procedure, the spine implant comprising:a cage having an upper side, a lower side opposite to the upper side, a first lateral side, a second lateral side opposite to the first lateral side, a first end, a second end opposite the first end, a medial cavity extending through the cage from the upper side to the lower side, an arcuate opening in the second end defining an upper shelf extending longitudinally from the upper side and a lower shelf extending longitudinally from the lower side, the upper shelf having a first edge and a lower surface, the lower shelf having a second edge and an upper surface, a rounded bore in the upper side adjacent the upper shelf and extending axially from the upper side to the lower surface, a round seat in the upper surface of the lower shelf and axially below the rounded bore, a lower arcuate groove in the upper surface of the lower shelf adjacent the second edge, an upper arcuate groove in the lower surface of the upper shelf adjacent the first edge, the lower arcuate groove and the upper arcuate groove axially aligned with one another and forming an arcuate channel of a first arcuate length for receipt and guidance of a distal protrusion on a distal end of a spine implant installation instrument for a TLIF surgical procedure along the arcuate channel during pivotal movement of the cage during implantation of the TLIF implant, and a cylindrical bore in the second lateral side of the cage in communication with the rounded bore;
a cylindrical pivot post disposed in the rounded bore of the cage and rotationally supported on the rounded seat, the cylindrical pivot post having a central axis, a threaded bore in a radial side thereof that extends radially inward toward the central axis, and a receptor disposed in an exterior surface of the cylindrical pivot post opposite to the threaded bore; and
a cylindrical retention pin received in the cylindrical bore in the second lateral side of the cage and in contact with the cylindrical pivot post to constrain the cage to a range of rotation about the cylindrical post and along the arcuate channel.

US Pat. No. 11,109,982

SYSTEM AND METHOD FOR TOTAL HIP ARTHROPLASTY

iHip Surgical, LLC, Foun...


1. A system for aligning a prosthetic acetabular cup in a pelvis of a patient, said system comprising:a trial cup, configured to fit into a reamed acetabulum in the pelvis of the patient;
a trial femoral head, trial neck and trial stem, said trial neck having a long axis;
a jig comprising a fixation element connected to a first rotatable and lockable joint, a first connecting rod connecting said first rotatable and lockable joint to a second rotatable and lockable joint, a second connecting rod connecting said second rotatable and lockable joint to a third rotatable and lockable joint and an aiming clamp;
a handle assembly comprising a handle portion characterized by a proximal end and a distal end, and an alignment shaft disposed on the proximal end of the handle portion, and a releasable coupling on the distal end, said releasable coupling configured for releasably coupling to the trial stem;
said alignment shaft characterized by a long axis, said handle portion configured to hold said alignment shaft with the long axis of the alignment shaft coaxial with a long axis of the trial neck;
wherein the fixation element is configured for temporary non-translating fixation to the pelvis;
the aiming clamp is configured for temporary fixation to the alignment shaft;
wherein the trial stem is configured for temporary non-translating fixation within a femur of the patient; and
wherein the first rotatable and lockable joint, the second rotatable and lockable joint, and the third rotatable and lockable joint and aiming clamp, are operable to be manipulated, upon manipulation of the femur, to a position corresponding to a desired orientation of the trial cup and the prosthetic acetabular cup, and operable to be fixed in a fixed position, said fixed position being a position corresponding to a desired orientation of the trial cup and the prosthetic acetabular cup.

US Pat. No. 11,109,981

DYNAMIC INTERVERTEBRAL SPACER IMPLANT

ADDITIVE IMPLANTS, INC., ...


1. A method of fusing first and second adjacent vertebral bodies, each vertebral body having concave endplates facing each other, the method comprising:inserting a spinal spacer into an intervertebral space between the first and second vertebral bodies adjacent the concave endplates on the first and second vertebral bodies, the implant comprising a body having a generally central axis and a centralized aperture extending through the body near the centralized axis;
the body further comprising:a first side having a first side perimeter and defining a first plane, an opposed second side having a second side perimeter and defining a second plane;
the first side perimeter connected at a first edge with a perimeter wall;
the second side perimeter connected at a second edge with the perimeter wall, wherein the perimeter wall separates the first side and second side; and
wherein the first side further comprises at least one lobe extending from the first perimeter toward the generally central axis; and

allowing the first and second vertebral bodies to converge creating a load on the implant, the at least one lobe engaging with one of the concave endplates so that the at least one lobe deflects to a degree commensurate with an increasing load.

US Pat. No. 11,109,980

INTERVERTEBRAL SPACER AND PLATE

Globus Medical Inc., Aud...


1. A method for inserting an implant between adjacent vertebral bodies, said method comprising:inserting the implant in between the adjacent vertebral bodies in a collapsed position;
expanding the implant to an expanded position; and
fastening the implant to the adjacent vertebral bodies,
wherein the implant comprises:a first endplate having a longitudinal axis, wherein the first endplate comprises a planar portion with protrusions and an extension portion, and wherein a superior most surface of the first endplate is adjacent a superior one of the adjacent vertebral bodies when the implant is inserted between the adjacent vertebral bodies;
a second endplate, wherein an inferior most surface of the second endplate is adjacent an inferior one of the adjacent vertebral bodies when the implant is inserted between the adjacent vertebral bodies;
a first ramped body extending between the first endplate and the second endplate, wherein the first ramped body comprises at least one upwardly facing ramp engaging the first endplate and at least one downwardly facing ramp engaging the second endplate;
an actuator in engagement with the first ramped body, wherein rotation of the actuator causes translation of the first ramped body, thereby causing the implant to expand into the expanded position; and
a first socket having a first axis, the first socket formed through the extension portion of the first endplate, wherein an entirety of the first socket is superior to the superior most surface of the first endplate and wherein the first axis of the first socket is oblique to the longitudinal axis of the first endplate;
a first anchor configured to fasten the implant to the adjacent vertebral bodies, wherein the anchor is received in the first socket; and
a first blocking fastener disposed in the extension portion of the first endplate, wherein an entirety of the first blocking fastener is superior to the superior most surface of the first endplate, wherein the first blocking fastener is configured to retain the first anchor in the first socket.


US Pat. No. 11,109,979

EXPANDABLE INTERBODY DEVICE


1. An expandable interbody device comprising:a support structure having a top side and a bottom side;
a top plate positioned on the top side of the support structure;
a bottom plate positioned on the bottom side of the support structure;
a plurality of gears rotatably connected to the support structure, wherein the plurality of gears are rotatable relative to the support structure and wherein the plurality of gears are arranged such that adjacent gears are rotationally interconnected;
a plurality of first racks that are coupled to the top plate, wherein the plurality of first racks are operationally connected to the plurality of gears such that rotating the plurality of gears in an opening direction moves the top plate away from the support structure by moving the plurality of first racks relative to the plurality of gears; and
a plurality of second racks that are coupled to the bottom plate, wherein the plurality of second racks are operationally connected to the plurality of gears such that rotating the plurality of gears in an opening direction moves the bottom plate away from the support structure by moving the plurality of second racks relative to the plurality of gears.

US Pat. No. 11,109,978

ELBOW JOINT PROSTHESES

HOWMEDICA OSTEONICS CORP....


1. A radial head assembly comprising:a stem comprising a convex articular head on one end thereof;
a collar comprising a collar wall defining a first collar opening, a second collar opening, and a passage therethrough, the collar wall having an interior collar surface comprising an angular portion proximate to the first collar opening;
a locking ring comprising a ring wall defining a ring opening, the ring wall having an angular outer surface and a slot configured to permit the ring wall to radially expand, the angular outer surface engaging the angular portion of the interior collar surface, wherein the locking ring further comprises a flange configured to engage the first collar opening and inhibit disengagement of the locking ring from the collar;
an articular member comprising:a base having an outer rim and a first concave surface; and
a projection extending from the base, the projection comprising a second concave surface disposed between the first concave surface and an end of the articular member opposite the first concave surface, the projection having a peripheral surface configured to engage the interior collar surface;

wherein the articular member and the locking ring define an articular space within the collar, the articular space configured to receive the convex articular head.

US Pat. No. 11,109,977

FEMORAL HIP JOINT SPACER WITH IRRIGATION DEVICE

HERAEUS MEDICAL GMBH, We...


1. A femoral hip joint spacer for temporary replacement of a part of a hip joint, the hip joint spacer comprising:a prosthesis body having a ball head with a surface including both an irrigation liquid inlet opening and an irrigation liquid outlet opening, a neck with a proximal side connected to the ball head and a distal side which is opposite the ball head, a stem connected to the neck on the distal side of the neck and including both a proximal side and a distal side, and an anchoring sleeve connected to the stem including both a proximal side and a distal side and enclosing the stem on the proximal side of the stem with a circumferential fastening area, wherein
the distal side of the stem includes at least one irrigation liquid discharge opening and either the ball head or the neck includes at least one irrigation liquid intake opening,
the at least one irrigation liquid discharge opening is connected inside the prosthesis body in a liquid-permeable manner to the irrigation liquid inlet opening and is not connected inside the prosthesis body in a liquid-permeable manner to the irrigation liquid outlet opening, and
the at least one irrigation liquid intake opening is connected inside the prosthesis body in a liquid-permeable manner to the irrigation liquid outlet opening and is not connected inside the prosthesis body in a liquid-permeable manner to the irrigation liquid inlet opening, and
the anchoring sleeve includes a cavity formed inside the anchoring sleeve which is open on two sides, the cavity connecting the proximal side of the anchoring sleeve to the distal side of the anchoring sleeve in a liquid-permeable manner.

US Pat. No. 11,109,975

ARTICULAR CARTILAGE REPAIR

Cytex Therapeutics, Inc.,...


1. An osteochondral interface repair implant for implantation within an osteochondral lesion, comprising:a moldable biocompatible three-dimensional woven fiber scaffold constructed of a plurality of layers of woven fibers adapted to allow integration of tissue from the cartilage surface and bone surface upon implantation, the plurality of layers of woven fibers including:at least one first layer made of fibers oriented in an x-direction;
at least one second layer made of fibers oriented in a y-direction, the y-direction orthogonal to the x-direction; and
at least one fiber oriented in a z-direction, the z-direction orthogonal to both the x-direction and the y-direction,

wherein the at least one first layer and the at least one second layer are connected to one another by the at least one fiber oriented in the z-direction,
wherein at least a portion of the fibers are coated with an inorganic matrix from the group consisting of hydroxyapatite, calcium phosphate, calcium carbonate, alumina, zirconia, yttria-stabilized zirconia, silicon nitride-based materials, bioactive glass, and/or glass ceramics,
wherein each of the fibers comprises a plurality of yarns, and the yarns of all of the fibers of the three-dimensional fiber scaffold are configured to be locked into a physical conformation with respect to one another after being molded such that the scaffold is structurally stable, and
wherein the plurality of layers includes an upper cartilage layer including a first plurality of said plurality of layers defining a first pore size and a lower osteogenic layer including a second plurality of said plurality of layers defining a second pore size that is greater than said first pore size.

US Pat. No. 11,109,974

CARDIAC TREATMENT SYSTEM AND METHOD

DiaxaMed, LLC, Raleigh, ...


1. A cardiac implant for implantation around an exterior of a heart, the implant comprising:an implant body comprising a mesh material in a tubular configuration that includes: (i) a leading end portion defining an open leading end configured to be positioned in an atrial-ventricular groove of the heart and (ii) a trailing end portion defining an open trailing end of a diameter that is less than a diameter of the open leading end; and
a first fillable bladder configured to be positioned adjacent to a tricuspid valve of the heart, the first fillable bladder attached to an exterior surface of the implant body, the first fillable bladder comprising a base layer and an expanding layer,
wherein the expanding layer includes a peripheral side wall and a generally planar pressure-exerting surface positioned within a periphery of the peripheral side wall,
wherein the pressure-exerting surface is adjacent to the exterior surface of the implant body,
wherein a height of the first fillable bladder is defined between the base layer and the pressure-exerting surface, and
wherein the peripheral side wall comprises one or more folds that are configured to unfold to increase the height of the first fillable bladder in response to pressurization of the first fillable bladder.

US Pat. No. 11,109,973

SYSTEM FOR EVALUATION OF PROSTHETIC HEART VALVES UNDER STEADY HYDRODYNAMIC CONDITIONS

Biomedical Device Consult...


1. A system for testing steady flow hydrodynamic performance of a valved prosthesis in both forward fluid flow and back fluid flow directions comprisinga reservoir storing a working fluid;
a fluid pump in fluid connection with the reservoir and configured to pump working fluid from the reservoir throughout the system;
a test conduit with a proximal end and a distal end and configured to hold a valved prosthesis within a lumen of the test conduit;
a pressure transducer configured to measure a pressure difference across the valved prosthesis held within the test conduit;
a first conduit extending between and in fluid connection with the distal end of the test conduit and the reservoir;
a variable first 2-way control valve positioned in line with the first conduit between the distal end of the test conduit and the reservoir;
a second conduit extending between and in fluid connection with the proximal end of the test conduit and the reservoir;
a first flow meter configured to measure a flow rate of the working fluid through the second conduit;
a second 2-way control valve positioned in line with the second conduit between the proximal end of the test conduit and the reservoir; and
a first 3-way control valve having an inlet in fluid connection with an outlet of the fluid pump, a first outlet in fluid connection with the proximal end of the test conduit, and a second outlet in fluid connection with the first conduit between the distal end of the test conduit and the variable first 2-way control valve, and configured to alternately direct the working fluid to either the test conduit or the first conduit exclusively;
wherein, without adjustment of the valved prosthesis within or removal of the valved prosthesis from the test conduit,in a first system configuration, the first 3-way control valve exclusively directs fluid flow to the proximal end of the test conduit and through the test conduit to the distal end, the variable first 2-way control valve is configured in a fully open position, the second 2-way control valve is configured in a fully closed position, and fluid flow is directed in a forward flow direction through the test conduit to pass through the valved prosthesis in an open position such that a first pressure drop value across the open valved prosthesis is measurable by the pressure transducer; and
in a second system configuration, the first 3-way control valve exclusively directs fluid flow to the first conduit and through the test conduit from the distal end to the proximal end, the variable 2-way control valve is configured in a partially open position, the 2-way control valve is configured in a fully open position, and fluid flow is directed through the test conduit in a reverse flow direction to pass through the valved prosthesis in a closed position such that a fluid leakage flow rate through the closed valved prosthesis is measurable by the first flow meter.


US Pat. No. 11,109,971

MITRAL VALVE ANNULOPLASTY DEVICE WITH TWISTED ANCHOR

Cardiac Dimensions Pty. L...


1. A mitral valve therapy device, the therapy device comprising:an expandable first anchor, an expandable second anchor, and a connecting member extending therebetween, a distal end, a proximal end, and an axis that extends between the distal and proximal ends and along the connecting member,
the expandable first anchor having an anchored configuration in which a first anchor apex is in an anchor portion that is spaced radially furthest away from the axis,
the expandable first anchor comprising a first segment and a second segment, and in the anchored configuration the first segment engages the second segment to form at least one full twist around the second segment in the apex of the expandable first anchor in which the first segment passes over the second segment and then under the second segment and then over the second segment, and in which the second segment passes under the first segment and then over the first segment and then under the first segment,
the expandable first anchor further comprising a securing member for securing an end of the first segment and an end of the second segment therein at a distal end of the securing member, the securing member generally aligned with the connecting member,
the first segment extending distally from the securing member, below the axis and away from the apex, and forming a first stress relief portion, the second segment extending distally from the securing member, below the axis and away from the apex, and forming a second stress relief portion,
wherein the first and second stress relief portions are located distal to where the first and second segments form the at least one full twist.

US Pat. No. 11,109,970

PROSTHETIC HEART VALVE AND DELIVERY APPARATUS

Edwards Lifesciences Corp...


1. An assembly for replacing a native heart valve, the assembly comprising:a prosthetic heart valve comprising an annular metal frame and a valve member disposed in an interior of the metal frame, wherein the metal frame is made of a shape-memory material, and wherein the metal frame includes connecting features extending from an outlet end of the metal frame, the valve member configured to direct blood flow towards the outlet end; and
a delivery apparatus comprising:a handle;
a shaft comprising a proximal end portion and a distal end portion, wherein the proximal end portion is coupled to the handle and the distal end portion is releasably coupled to the prosthetic heart valve, wherein the distal end portion comprises an annular end piece that is entirely continuous around a central lumen, the end piece having recesses that receive the connecting features of the frame;
a delivery sheath; and
a hydraulic power source operatively connected to the delivery sheath;

wherein the prosthetic heart valve is positioned within the delivery sheath in a radially compressed state;
wherein the hydraulic power source is configured to move the delivery sheath in a first axial direction relative to the prosthetic heart valve to uncover the prosthetic heart valve and allow the prosthetic heart valve to self expand from the radially compressed state to a radially expanded state; and
wherein the hydraulic power source is also configured to move the delivery sheath in a second axial direction relative to the prosthetic heart valve to cause the delivery sheath to recover and radially compress the prosthetic heart valve from the radially expanded state to the radially compressed state.

US Pat. No. 11,109,969

GUIDEWIRE DELIVERY OF TRANSCATHETER HEART VALVE

VDyne, Inc., Maple Grove...


1. A delivery system for deployment of a transcatheter prosthetic valve, comprising:(i) a hypotube sheathed guidewire assembly having an outer sheath and an inner guidewire shaft;
(ii) a transcatheter prosthetic valve having an annular support frame with an atrial sealing collar, a flow control component mounted within the annular support frame, the annular support frame having a central axis, the flow control component is configured to permit blood flow in a first direction through an inflow end of the transcatheter prosthetic valve and block blood flow in a second direction, opposite the first direction, through an outflow end of the transcatheter prosthetic valve,
a tension arm extends from a distal side of the annular support frame, the tension arm comprised of wire loop or wire frame, integrated frame section, or stent, extending from about 10-40 mm away from the annular support frame, said tension arm having a guidewire collar attached to the tension arm, wherein the guidewire collar is sized and configured with a guidewire aperture to allow the inner guidewire shaft to pass through the guidewire aperture, and to block passage of the outer sheath of the guidewire assembly through the guidewire aperture;
(iii) a delivery catheter, the delivery catheter comprising an elongated tube with a central lumen, the lumen having a diameter from about 7 to 12 mm, the delivery catheter has a length-wise cylindrical axis substantially perpendicular to the central axis of the annular support frame of the transcatheter prosthetic valve when the transcatheter prosthetic valve is disposed within the delivery catheter;
wherein the transcatheter prosthetic valve is compressible to a compressed configuration for introduction into the body using the delivery catheter for implanting at a desired location in the body,
wherein the tension arm exits a distal end of the delivery catheter before the annular support frame,
wherein the transcatheter prosthetic valve is expandable to an expanded configuration having a height of about 5-60 mm and a diameter of about 25-80 mm,
wherein the compressed configuration of the transcatheter prosthetic valve has a compressed height configured to fit within the central lumen of the delivery catheter, a folded width configured to fit within the central lumen of the delivery catheter, and a length that is uncompressed along a long axis,
wherein in said compressed configuration the long axis is oriented at an intersecting angle of between 45-135 degrees to the first direction, and in said expanded configuration the long axis is oriented at an intersecting angle of between 45-135 degrees to the first direction,
wherein the long axis of the compressed configuration of the valve is substantially parallel to the length-wise cylindrical axis of the delivery catheter when the transcatheter prosthetic valve is disposed within the delivery catheter.

US Pat. No. 11,109,968

APPARATUS AND METHODS FOR IMPROVED LOADING OF A TRANSCATHETER HEART VALVE

St. Jude Medical, Cardiol...


1. A device for collapsing a prosthetic heart valve, comprising:a compression member including a support having a central axis and a plurality of arms pivotably connected to the support, each of the arms having an inner surface facing the central axis, a pair of side edges, and a free end, the arms being pivotable between a first orientation in which the side edges of adjacent arms are spaced apart from one another and a second orientation in which the side edges of the adjacent arms contact one another, the inner surfaces of the arms collectively defining a compression surface in the second orientation, the compression surface decreasing uniformly in diameter from a first end adjacent the support to a second end adjacent the free ends of the arms, wherein each of the arms extends a length between the support and the free end of the arm and includes an outer side facing away from the central axis, the outer side including a plurality of grooves oriented transverse to the length and spaced apart from one another along the length of the arm, the plurality of grooves collectively defining a threaded portion; and
a translating member threadedly assembled to the threaded portion of the compression member so that rotation of the translating member relative to the compression member moves the translating member along the arms from an initial position in which the arms are in the first orientation and the translating member is relatively close to the support to a final position in which the arms are in the second orientation and the translating member is relatively distant from the support, movement of the translating member from the initial position to the final position pivoting the arms from the first orientation to the second orientation.

US Pat. No. 11,109,967

SYSTEMS AND METHODS FOR LOADING AND DEPLOYING AN INTRAVASCULAR DEVICE

CEPHEA VALVE TECHNOLOGIES...


1. An intravascular device delivery system for delivery of an intravascular device, the system comprising:an intravascular device, and
an elongated member having a distal end and a proximal end with a longitudinal axis extending therebetween, the elongated member including:a coil extending from the proximal end of the elongated member toward the distal end of the elongated member,
a distal end cap longitudinally fixed to a distal end of the coil and positioned within an intravascular device cover that selectively retains the intravascular device,
a delivery catheter positioned longitudinally overlapping at least a portion of the coil, and
a delivery disc longitudinally fixed to the delivery catheter, the delivery disc being proximal to the distal end cap; and

a disc handle configured to move the distal end cap and delivery disc, the disc handle including:a main body distal end cap configured to move the distal end cap, and
a movable body configured to move the delivery disc longitudinally relative to the distal end cap,
wherein, the distal end cap is disposed on a disc handle side of the intravascular device positioned within the intravascular device cover in a pre-deployed configuration.


US Pat. No. 11,109,966

CENTERING DEVICES FOR USE WITH A VALVE PROSTHESIS DELIVERY SYSTEM AND METHODS OF USE THEREOF

MEDTRONIC VASCULAR, INC.,...


1. A method of delivering a valve prosthesis configured for delivery within a vasculature, the method comprising the steps of:percutaneously introducing a valve centering catheter into a vasculature, the valve centering catheter having a longitudinal centering device at a distal portion thereof, wherein the longitudinal centering device is in a delivery configuration;
tracking the valve centering catheter through the vasculature until the longitudinal centering device is positioned distal to a treatment site;
radially expanding the longitudinal centering device into an expanded configuration, wherein the longitudinal centering device defines a central opening there-through when in the expanded configuration;
percutaneously introducing a valve delivery system into the vasculature separately from the valve centering catheter, the valve delivery system comprising a shaft and having a valve prosthesis mounted at a distal portion thereof and including a circumferential centering device proximal to the valve prosthesis, wherein the valve prosthesis and the circumferential centering device are in delivery configurations;
tracking the valve delivery system through the vasculature until the valve prosthesis is positioned at the treatment site, proximal to the expanded longitudinal centering device, wherein the expanded longitudinal centering device serves as a depth marker in order to longitudinally center the valve prosthesis within the native anatomy of the treatment site;
radially expanding the circumferential centering device of the valve delivery system into an expanded configuration, wherein the circumferential centering device defines a central opening there-through when in the expanded configuration;
deploying the valve prosthesis into apposition with the native anatomy of the treatment site, thereby anchoring and securing the valve prosthesis within the native anatomy of the treatment site.

US Pat. No. 11,109,965

TRANSCATHETER HEART VALVE PROSTHESIS ASSEMBLED INSIDE HEART CHAMBERS OR BLOOD VESSELS

Laplace Interventional In...


1. A prosthetic tricuspid valve comprising:a main body comprising an occluder having valve leaflets;
a first anterior flap extending laterally from an end of the main body; and
a second anterior flap extending laterally from the end of the main body in a same direction as the first anterior flap,
wherein portions of the first anterior flap and the second anterior flap overlap each other when the prosthetic tricuspid valve is deployed, and
wherein having the portions of the first anterior flap and the second anterior flap that overlap each other increases a bending resistance of the first anterior flap and the second anterior flap in combination as compared to the first anterior flap and the second anterior flap individually.

US Pat. No. 11,109,964

AXIALLY-SHORTENING PROSTHETIC VALVE

CARDIOVALVE LTD., Or Yeh...


1. A method for use at an atrioventricular valve that has an annulus and is disposed between an atrium and a ventricle of a heart of a subject, the method comprising:transluminally advancing a catheter to the heart;
via the catheter, advancing to the heart a prosthetic valve including:an upstream annular skirt,
a downstream skirt having:a first portion defining a lumen therethrough, and
a second portion circumscribing the first portion,

a plurality of anchoring arms, each of the anchoring arms having a first end that is coupled to the second portion, and an opposite end that is a free end, and
a plurality of prosthetic leaflets attached to the first portion and disposed within the lumen;

expanding the upstream annular skirt in the atrium and expanding the anchoring arms in the ventricle such that:the upstream annular skirt becomes disposed over the annulus, and
each of the anchoring arms becomes oriented to lead in a direction from the first end to the opposite end, the direction being radially outward and toward the upstream annular skirt; and

subsequently to expanding the upstream annular skirt in the atrium, and while each of the anchoring arms remains oriented to lead in the direction from the first end to the opposite end, squeezing tissue of the atrioventricular valve between the upstream annular skirt and the anchoring arms by causing the second portion of the downstream skirt and the anchoring arms to move:(i) with respect to the prosthetic leaflets, and
(ii) toward the upstream annular skirt.


US Pat. No. 11,109,963

PROSTHETIC VALVES WITH MECHANICALLY COUPLED LEAFLETS


1. A prosthetic valve comprising:a plurality of leaflets including a first leaflet and a second leaflet, each leaflet having a leaflet attachment region and each leaflet having a free edge; and
a frame including a commissure post that comprises:a first tine including a first interior edge and a first exterior edge opposite the first interior edge, the first tine including a first projection extending from the first exterior edge of the first tine;
and a second tine including a second interior edge and a second exterior edge opposite the second interior edge, the second tine including a second projection extending from the second exterior edge of the second tine;
a spine positioned between the first and second tines such that the interior edges of the first and second tines face the spine, the spine being positioned between at least a portion of the first and second leaflets such that a gap is defined between the leaflet free edges of the first and second leaflets adjacent the commissure post; and
a first slot and a second slot, the first slot being defined between the first tine and the spine, and the second slot being defined between the second tine and the spine,

wherein the leaflet attachment region of the first leaflet extends through the first slot and wraps around the first tine and engages the first projection, and wherein a first portion of the leaflet attachment region of the second leaflet extends through the second slot and wraps around a portion of the second tine and engages the second projection.

US Pat. No. 11,109,960

DUAL OPTIC, CURVATURE CHANGING ACCOMMODATIVE IOL

Alcon Inc., Fribourg (CH...


1. A method of treating a vision disorder, comprising:inserting an intraocular lens within a capsular bag of a patient's eye, the intraocular lens comprising:a fluid optic body comprising a cavity for containing an optical fluid, the cavity at least partially defined by:a deformable optical membrane defining an anterior surface of the cavity;
a second optical membrane defining a posterior surface of the cavity; and
a sidewall having an anterior end connected to the deformable optical membrane and a posterior end connected to the second optical membrane such that the sidewall extends between the deformable optical membrane and the second optical membrane;

a second optic body spaced a distance apart from the fluid optic body; and
a plurality of struts extending from the sidewall and coupling the fluid optic body to the second optic body, the struts being configured such that axial compression of the capsular bag causes the plurality of struts to rotate the sidewall about a pivot in a manner that increases a diameter of the cavity at the anterior end of the sidewall more than a diameter of the cavity at the posterior end of the sidewall such that a radius of curvature of the deformable optical membrane is increased;

disposing the fluid optic body within the capsular bag such that the deformable optical membrane is disposed across an optical axis of the eye; and
disposing the second optic body within the capsular bag such that the second optic body is disposed across the optical axis of the eye.

US Pat. No. 11,109,959

INTRAOCULAR LENS AND METHOD OF MANUFACTURING THE SAME

KOREA INSTITUTE OF SCIENC...


1. An intraocular lens (IOL), comprising:an optic portion having a circular shape and including a first pattern which includes a plurality of ridges and a plurality of grooves; and
a plurality of haptic portions extending from an outer circumferential edge of the optic portion and each including a second pattern which includes a plurality of ridges and a plurality of grooves,
wherein at least one of the ridges included in the first pattern and the second pattern and at least one of the grooves included in the first pattern and the second pattern includes a section in which a width is formed differently,
wherein the widths of the grooves of the second pattern in a haptic portion of the plurality of haptic portions is wider than the widths of the grooves of the first pattern in the optic portion,
wherein a groove of at least one of the first and second patterns includes a rugged part of nanometer units formed on a bottom surface thereof and a plurality of nano-sized projections formed on a side surface thereof,
wherein the first pattern is formed over the haptic portions and the optic portion, and the second pattern is formed only on the haptic portions.

US Pat. No. 11,109,958

POSTERIOR CHAMBER PHAKIC INTRAOCULAR LENS

PhysIOL, Angleur (BE)


1. A posterior chamber phakic intraocular lens comprising:an anterior surface and a posterior surface;
a central optical part comprising a lens, and extending radially relative to an optical axis directed from said anterior surface to said posterior surface;
a peripheral haptic part extending radially outward relative to said central optical part, said peripheral haptic part comprising:a proximal portion extending circumferentially around said central optical part;
a distal portion at least around said proximal portion and comprising a plurality of support elements extending both radially outward and posteriorly relative to said central optical part, said support elements being configured for supporting said phakic intraocular lens on a ciliary zonule when the phakic intraocular lens is in the implantation position in an eye;

said central optical part and said peripheral haptic part forming a dome;
at least one flexible haptic comprising:a proximal region at least around said proximal portion of said peripheral haptic part;
a distal region at least around said proximal region and comprising a plurality of distal elongated flexible footplates that extend at least partially radially outward relative to said central optical part, and that border distal cavities extending between said anterior and said posterior surfaces,

wherein the peripheral haptic part has a thickness, measured in parallel to the optical axis, larger, on average, than that of the flexible haptic,
a first diameter of said phakic intraocular lens being strictly greater than a second diameter of an optical assembly consisting of said central optical part and said peripheral haptic part, measured perpendicularly to said optical axis;
at least one of said distal elongated flexible footplates extending substantially between said second and said first diameters;
said distal region comprising a distal border connecting at least two of said distal elongated flexible footplates, said distal border being configured for stabilizing said phakic intraocular lens into a ciliary sulcus when the phakic intraocular lens is in an implantation position in the eye,
wherein said proximal region of the at least one flexible haptic comprises a plurality of proximal elongated flexible footplates that extend at least partially radially outward and posteriorly relative to said central optical part, and that border proximal cavities extending between said anterior and said posterior surfaces,
wherein said proximal elongated flexible footplates of said proximal region are oriented and substantially parallel to a first direction, and/or said distal elongated flexible footplates of said distal region are oriented and substantially parallel to a second direction, and
wherein said first direction is transverse to said second direction and said first and said second directions form a smaller angle between them of between 80° and 140°.

US Pat. No. 11,109,957

INTRAOCULAR PSEUDOPHAKIC CONTACT LENS WITH MECHANISM FOR SECURING BY ANTERIOR LEAFLET OF CAPSULAR WALL AND RELATED SYSTEM AND METHOD

OnPoint Vision, Inc., Al...


1. An apparatus comprising:an intraocular pseudophakic contact lens comprising:an optical lens; and
haptics extending radially from the optical lens and configured to be inserted under an anterior leaflet of a capsular wall in an eye in order to capture and confine the haptics under the anterior leaflet and secure the intraocular pseudophakic contact lens against an artificial intraocular lens in the eye;

wherein anterior surfaces of the haptics comprise capsular wall-engaging surfaces configured to contact an inner capsular wall surface at the anterior leaflet, the capsular wall-engaging surfaces configured to promote confinement, capture, or attachment of the haptics;
wherein posterior surfaces of the haptics comprise ridges configured to capture at least one edge of the artificial intraocular lens in order to secure the intraocular pseudophakic contact lens to the artificial intraocular lens; and
wherein at least part of the anterior surface of each of the haptics is angled posteriorly with respect to an anterior surface of the optical lens and at least part of the posterior surface of each of the haptics is angled posteriorly with respect to a posterior surface of the optical lens.

US Pat. No. 11,109,955

DERMAL LAYER FOR GRAFTING HAVING IMPROVED GRAFT SURVIVAL RATE AND METHOD FOR PRODUCING SAME

PHARMARESEARCH CO., LTD.,...


1. A method for producing a dermal layer for grafting, the method comprising:a) preparing a stock solution containing a DNA fragment mixture, wherein the DNA fragment mixture is from fish testis or sperm;
b) preparing a chitosan stock solution;
c) mixing the DNA fragment mixture stock solution and the chitosan stock solution in a weight ratio of 20:1-10,000:1 of the DNA fragment mixture to chitosan;
d) stirring the resulting mixture of the DNA fragment mixture stock solution and the chitosan stock solution;
e) sterilizing the mixture of the DNA fragment mixture stock solution and the chitosan stock solution to obtain a loading solution; and
f) loading the loading solution to an acellular dermal matrix to obtain the dermal layer.

US Pat. No. 11,109,954

ANCHOR FOR MEDICAL USE, TO BE INSERTED INTO A BONY WALL

Dediene Sante, Mauguio (...


1. An anchor (1) for medical use, intended to be inserted into a bony wall, comprising:an outer part having a proximal side and a longitudinal direction, intended to be fastened to the bone, which forms an inner longitudinal cavity therethrough; and
an inner part having a longitudinal direction, intended to be inserted and held in said cavity of the outer part, which forms a transverse conduit passing all the way through it;
having an axis; at least one suture thread is intended to be engaged in said cavity through the proximal side of the outer part, to be engaged through said transverse conduit and to emerge from said outer part, through said proximal side;
wherein:
the outer part forms at least one first jamming surface arranged in the longitudinal direction of the outer part and the inner part forms at least one second jamming surface located on the proximal side relative to the transverse conduit that it comprises, the second jamming surface being arranged in the longitudinal direction of the inner part;
said at least one suture thread is intended to extend along said first jamming surface and along said second jamming surface;
the inner part is movable relative to the outer part between a distal position not blocking the suture thread, in which said second jamming surface is at a distance from said first jamming surface not performing any jamming of this thread, and a proximal blocking position of the suture thread, in which said second jamming surface is at a distance from said first jamming surface performing jamming of the thread;
wherein said outer part comprises two said first jamming surfaces, diametrically opposite, and said inner part comprises two corresponding said second jamming surfaces; and
wherein at least one of said first and second jamming surfaces is inclined relative to the longitudinal axis of the anchor.

US Pat. No. 11,109,953

PACKAGE, PREFERABLY MEDICAL, AND CORRESPONDING SET OF PACKAGES

SELENIUM MEDICAL, La Roc...


1. A package for an object said package comprising:a bottom shell; and
a top shell;
wherein the package the top shell comprises:
a closure portion; and
a connection portion configured in the form of a hollow body, and connected to the closure portion by a hinge;
the connection portion being provided with a stiffener element configured to impart stiffness to the top shell, the stiffener element being spaced apart from the hinge; and
in that said package also comprises:
a sealing strip connecting together facing edges of the closure portion and of the connection portion over an entire length of said facing edges in such a manner as to seal the package; and
the bottom shell and said connection portion of the top shell being two parts that are fastened to each other in a non-separable manner.

US Pat. No. 11,109,952

VAGINAL DEVICE

Invent Medic Sweden AB, ...


1. A vaginal device for preventing urinary incontinence made of an elastic material, the vaginal device comprises:a longitudinal portion having a geometrical centre line, a first end and a second end, the first end being the innermost of the vaginal device during use;
at least one supporting portion protruding from the longitudinal portion at the first end, the at least one supporting portion being configured to support against the urethra, through the vaginal wall, at a site located adjacent the maximal urethral pressure point;
a reference member protruding from the longitudinal portion at the second end, wherein the reference member during use is fixated against the vaginal introitus, holding the vaginal device securely fixated inside of the vagina and ensuring the at least one supporting portion is arranged at the intended site;
wherein a section of the longitudinal portion, arranged between the supporting portion and the reference member, has a decreasing cross-section towards the reference member and/or has at least one groove in an outer surface along an axial direction of the section.

US Pat. No. 11,109,951

ORAL CARE IMPLEMENT SUBSTRATES FOR ORAL CARE DEVICES

Willo 32 SAS, Limoges (F...


1. An oral care implement comprising:a woven substrate having a mesh of woven material woven in two different directions, and having a first mounting surface and a second surface which is different than the first mounting surface; and
a plurality of oral care elements extending from the first mounting surface in another direction distinct from the two different directions;
wherein the plurality of oral care elements each form at least one return path through the first mounting surface; and
wherein the plurality of oral care elements are attached to the second surface.

US Pat. No. 11,109,950

COMBINATION ELECTRIC TOOTHBRUSH AND WATER IRRIGATION DEVICE


1. A compact portable combination oral hygiene device combining an electric toothbrush and a water irrigator, the combination oral hygiene device comprising:(a) a pump housing and handle portion, the pump housing and handle portion comprising a bottom, a top, an inner wall, and an outer wall;
(b) a water exit tube comprising an exit port end and a connection fitting port end;
(c) a brush assembly composed of a brush head and a brush neck, the brush head comprising an aperture, wherein the exit port end is located in the brush head aperture for dental irrigation wherein the irrigation is activated by a user by a switch provided on the pump housing and handle portion;
(d) a hollow portion above the pump housing and handle portion comprising connection means for removably attaching the brush assembly and the water exit tube to the hollow portion, wherein the connection means comprises a quarter turn brush neck connector joint and a fitting exit tube male connector; the hollow portion furthermore comprising a direct current vibration generating motor having an off-center weight attached to a motor shaft, wherein the off-center weight causes vibrations to the motor shaft, wherein furthermore the brush neck and the brush head are vibrated by the motor shaft vibrations, wherein the direct current vibration generating motor is controlled independently of the water irrigator by a dedicated switch located on the brush neck;
(e) a water reservoir housing, comprising an open top, a closed bottom, an inner wall, an outer wall, and a gasket at the water reservoir housing top; the pump housing and handle portion slidably inserted into the water reservoir housing through the gasket, wherein the gasket provides a water-tight seal between the water reservoir housing inner wall and the pump housing and handle portion outer wall, thereby providing for a slidably variable length and variable volume no-spill water container; and
(f) a charging stand.

US Pat. No. 11,109,948

WORKPIECE UNIT AND METHOD OF PRODUCING SAME

KURARAY NORITAKE DENTAL I...


1. A workpiece unit, comprising:a workpiece body formed from a first material with a first thermal expansion coefficient; and
a holding member formed from a second material with a second thermal expansion coefficient, the second thermal expansion coefficient being larger than the first expansion coefficient,
wherein the workpiece body has a first face, a second face arranged opposite to the first face, and outer circumferential sidewalls between the first face and the second face;
wherein the holding member has a first holding face, a second holding face opposite to the first face, and inner circumferential sidewalls between the first holding face and the second holding face, the inner circumferential sidewalls sized and shaped to surround the workpiece body and substantially match at least a portion of the outer circumferential sidewalls;
wherein the holding member is configured to thermally expand by heating to allow the workpiece to be inserted inside the holding member and thermally contract with the removal of heat and secure the inner circumferential sidewalls to at least a portion of the outer circumferential sidewall with contraction stress of the holding member against the workpiece body without adhesive; and
wherein the holding member is configured to be removable from the workpiece body by thermally expanding the holding member by heating both the holding member and the workpiece body.

US Pat. No. 11,109,947

METHOD FOR PERFORMING AN OPTICAL THREE-DIMENSIONAL RECORDING

DENTSPLY SIRONA Inc., Yo...


1. A method of recording three-dimensional images of a physical jaw using a dental camera, comprising:displaying a virtual three-dimensional standard jaw model corresponding to the physical jaw on a display device;
displaying a first and a second virtual control point on a first and second virtual tooth of the virtual three-dimensional standard jaw model respectively;
determining a virtual recording path disposed between two virtual teeth, said virtual recording path disposed between two virtual teeth is defined by a visible path disposed between the first virtual control point on the first virtual tooth and the second virtual control point on the second virtual tooth, the first virtual tooth is different from the second virtual tooth;
displaying said virtual recording path disposed between two virtual teeth on the virtual three-dimensional standard jaw model;
operating the camera to automatically generate a plurality of three-dimensional images of the physical jaw in succession along portions of the physical jaw corresponding to the virtual recording path, by moving the dental camera relative to the physical jaw and automatically recording the plurality of three-dimensional images at a constant frequency, the automatic recording at the constant frequency starts from a portion of the physical jaw corresponding to the first virtual tooth, follows a direction of the virtual recording path, and ends at another portion of the physical jaw corresponding to the second virtual tooth.

US Pat. No. 11,109,945

METHOD OF EVALUATING AN ORTHODONTIC ALIGNER

DENTAL MONITORING, Paris...


1. A method for evaluating the shape of an orthodontic aligner worn by a patient, said method comprising the following steps:1) acquisition of at least one two-dimensional image of teeth of said patient, referred to as “updated image”, under actual acquisition conditions;at least one updated image referred to as “aligner image”, at least partially representing the aligner in a service position in which it is worn by said teeth; and at least one updated image referred to as “dentition image”, identical to or different from the aligner image, representing said teeth,

2) if the dentition image is different from the aligner image, conversion of the dentition image so that it represents said teeth as seen under the acquisition conditions used during the acquisition of the aligner image in step 1);
3) determination, by means of image processing software, for each of a plurality of teeth represented on the dentition and aligner images, of interior and exterior tooth outlines representing the outline of the free end of said tooth on the dentition and aligner images, respectively;
4) comparison of the interior and exterior tooth outlines, so as to determine at least one score according to said comparison.

US Pat. No. 11,109,944

DEVICE FOR PROVIDING ENDODONTIC MATERIAL HAVING A CARTRIDGE INCLUDING AN ELECTRICALLY CONDUCTIVE HEATING LAYER

DENTSPLY SIRONA Inc., Yo...


1. A cartridge comprising:an endodontic material unit having a chamber structure configured to contain endodontic material;
an electrical insulation layer provided on an outer surface of the chamber structure along a length of the endodontic material unit; and
an electrically conductive heating layer having at least two zones of different resistive values provided on the electrical insulation layer, along a length of the endodontic material unit;
a first electrode positioned at one side of the endodontic material unit, the first electrode being in electrical contact with the heating layer;
a second electrode positioned at a second side of the endodontic material unit, the second electrode being in electrical contact with the heating layer;
an outer sleeve encasing the endodontic material unit including the chamber structure, the heating layer, and the electrodes;
a thermal insulation layer provided on the heating layer and between the electrodes;
wherein an air gap is provided between the thermal insulation layer and the outer sleeve.

US Pat. No. 11,109,943

POWDER-BLASTING DEVICE


1. A powder-blasting device for cleaning dental surfaces by applying a powder-gas mixture, comprising:a stationary unit with a connecting section for a mixing chamber for producing the powder-gas mixture,
a handpiece with a nozzle device for blasting the powder-gas mixture onto a dental surface, and
a joining unit for connecting the handpiece with the stationary unit,
wherein the joining unit comprises a joining guide, between the stationary unit and the handpiece, and a powder gas line disposed in the joining guide,
wherein a lockable tube section, lockable by means of elastic deformation, is disposed in the powder gas line between the mixing chamber and the nozzle device,
wherein the joining unit is detachably connected with the stationary unit, and comprises a housing body that includes a rigid housing for holding and accommodating the lockable tube section,
wherein the joining unit comprises a first coupling section for coupling to a corresponding second coupling section of the stationary unit, and the first coupling section is disposed on the housing body of the joining unit such that the housing body of the joining unit is directly detachably connected to the housing of the stationary unit;
wherein a pinch valve is at least partially integrated into the joining unit; and
wherein between the stationary unit and the joining unit an air connection is provided for operating the pinch valve.

US Pat. No. 11,109,941

TRACKING SURGICAL ITEMS WITH PREDICTION OF DUPLICATE IMAGING OF ITEMS

Gauss Surgical, Inc., Me...


1. A computer-implemented method for tracking surgical textiles, comprising:receiving a first image comprising a first textile-depicting image region;
receiving a second image comprising a second textile-depicting image region;
measuring a likelihood that the first and second image regions depict at least a portion of the same textile;
incrementing an index counter without requiring user confirmation, based on the likelihood not meeting a predetermined first threshold;
determining an image transformation between the first and second image regions;
adjusting the second image region relative to the first image region based on the image transformation;
displaying the first image region and the adjusted second image region on a display device,
incrementing the index counter, after providing notification and receiving user confirmation that the first and second images do not represent the same textile, based on the likelihood exceeding the predetermined first threshold but not exceeding a predetermined second threshold; and
not incrementing the index counter, despite receiving user input that the first and second images do not represent the same textile, based on the likelihood exceeding the predetermined second threshold.

US Pat. No. 11,109,940

DEVICES, APPARATUSES, SYSTEMS AND METHODS FOR FACILITATING CLEANING OF AN IMAGING ELEMENT OF AN IMAGING DEVICE

ClearCam Inc., Austin, T...


1. An imaging element cleaning apparatus, comprising:a surgical system attachment body adapted for being engaged with one or more structural components of a robotic surgical system for at least partially securing the imaging element cleaning apparatus thereto;
a sheath assembly comprising a scope sheath, a cleaning member and a coupling element, wherein the coupling element is movably attached to the scope sheath and wherein the cleaning member is attached to a first end portion of the coupling element and is adjacent a first end portion of the scope sheath;
a sheath mount attached to the surgical system attachment body, wherein the scope sheath is attached at a second end portion thereof to the sheath mount; and
a motion control device having a mounting portion attached to the surgical system attachment body and a rotational movement imparting portion attached to a second end portion of the coupling element;
wherein the scope sheath is detachably attached to the sheath mount.

US Pat. No. 11,109,939

INTRAVASCULAR DEVICES WITH RADIOPAQUE BODY MARKERS

DEPUY SYNTHES PRODUCTS, I...


1. An intravascular treatment device comprising:an elongated guide; and
an expandable framework movable from a collapsed configuration sized to traverse a lumen of a catheter to an expanded configuration sized to extend within a lumen of a blood vessel, the expandable framework comprising:a plurality of ring struts, each ring strut encircling the elongated guide, and each ring strut movable from a constricted position around the elongated guide when the expandable framework is in the collapsed configuration to a radially expanded position around the elongated guide when the expandable framework is in the expanded configuration;
a plurality of central struts, each central strut joining two adjacent ring struts of the plurality of ring struts such that each ring strut is joined by one or more central struts of the plurality of central struts to only a first adjacent ring strut, each central strut comprising a shape when the expandable framework is in the collapsed configuration that is essentially the same as a shape of the central strut when the expandable framework is in the expanded configuration; and
a plurality of bent struts, each bent strut joining two adjacent ring struts of the plurality of ring struts such that each ring strut is joined by one or more bent struts of the plurality of bent struts to only a second adjacent ring strut opposite the first adjacent ring strut, each of the plurality of bent struts movable from a longitudinally elongated shape when the expandable framework is in the collapsed configuration to a radially expanded shape when the expandable framework is in the expanded configuration, wherein the expandable framework further comprises a proximal end and a distal end, wherein the proximal end is affixed to the elongated guide, and wherein the distal end is slidably movable over the elongated guide.


US Pat. No. 11,109,938

MULTI-SPOT LASER PROBE WITH ILLUMINATION FEATURES

Alcon Inc., Fribourg (CH...


1. A multi-fiber, multi-spot laser probe, comprising:a plurality of fibers extending from a proximal end of the laser probe to at least near a distal end of the laser probe, wherein the proximal end of the laser probe is configured to be coupled to a laser source;
a cannula having a distal end and surrounding the plurality of fibers along at least a portion of the laser probe at or near the distal end of the laser probe; and
an illumination fiber extending from the proximal end of the laser probe to at least near the distal end of the laser probe, wherein the illumination fiber has a diameter substantially smaller than corresponding diameters for the plurality of fibers and is arranged, at the proximal end of the illumination fiber, for coupling to a visible light source;
wherein the illumination fiber extends along the laser probe within the cannula;
wherein the illumination fiber is arranged at approximately a longitudinal center of the cannula;
wherein the plurality of fibers are movable as a group onto one or more distal ramps that are configured to curve the plurality of fibers outward relative to each other;
wherein the illumination fiber is fixed relative to the probe such that the plurality of fibers move relative to the fixed illumination fiber.

US Pat. No. 11,109,937

INSTRUMENTS AND METHODS FOR SUBPERIOSTEAL TUNNELING AND RELATED SURGICAL PROCEDURES


1. A suite of surgical instruments for subperiosteal tunneling comprising:a first elevator having a base portion comprised of a handle having an ergonomic grip, a first elongated shaft region, a second elongated shaft region and terminating in a distal curved and rectangular atraumatic tip;
a second elevator having an ergonomic grip, a first elongated shaft region, a second shaft region having a curved transitional portion and terminating in a distal curved atraumatic tip, wherein a combination of an angled portion of the first elongated shaft region and a second curved transitional portion and the second shaft region have positive values for at least two angles along the length of the second elevator such that the distal curved atraumatic tip is comprised of an arc region that disposes a most distal portion of the distal tip outside an axis of the first elongated shaft region; and
a third elevator having an ergonomic grip, and first, second, and third shaft regions having an angled portion therebetween such that the third shaft region has an angled portion relative to the first shaft region greater than 90° and less than 180°.

US Pat. No. 11,109,936

CATHETER STABILITY INDICATION

Biosense Webster (Israel)...


1. A method, comprising the steps of:introducing a probe into a fluid-filled body cavity of a subject, the fluid-filled body cavity having a temperature, the probe having a temperature sensor on a distal portion of the probe thereon, the body cavity having an interior wall;
passing an irrigating fluid through the probe, wherein the irrigating fluid exits the probe at the distal portion into the body cavity, and wherein a temperature of the irrigating fluid is different from the temperature of the body cavity;

while passing the irrigating fluid, recording temperature readings of the temperature sensor, wherein recording temperature readings comprises recording a first temperature reading and thereafter recording a second temperature reading, the contact criteria comprising the second temperature reading being lower than the first temperature reading, the method further comprising reporting a contact between the probe with the interior wall responsively to the determination and wherein the second temperature reading comprises transient elevations between 1 to 4 degrees C. that are between 0.3 to 5 seconds in duration and the method still further comprising reporting an intermittent contact between the probe and the interior wall;making a determination from the temperature readings that predetermined contact criteria between the probe and the interior wall of the body cavity are satisfied; and
thereafter alerting an operator that the contact criteria are satisfied.

US Pat. No. 11,109,935

DISPOSABLE CONTAINER FOR SURGICAL INSTRUMENTS

HPC Healthline UK Limited...


10. A method of sterilising a surgical instrument comprising:sealing a surgical instrument within a sterilising bag;
placing the sterilising bag containing the instrument within a disposable container, the disposable container being formed from a moulded pulp material and comprising;an enclosure comprising a base and an upstanding wall extending from the base and tapering outwardly an upwards direction towards its upper edge and a securing lip located at the upper edge of the upstanding wall;
a lid configured to close the enclosure, the lid being hingedly connected to the upper edge of the upstanding wall;
the lid includes a roof, an inner wall extending downwardly from the roof to a base, an outer wall extending upwardly from the base of the inner wall tapering outwardly away from the inner wall in the upwards direction at substantially the same angle as the upstanding wall of the enclosure, and a securing lip located at the upper end of the outer wall configured to secure over the securing lip of the enclosure, wherein when the lid and the enclosure are configured such that when the lid is in the closed position the base of the inner and outer walls is located within the enclosure at a position below the securing lip, a portion of the inner wall of the lid is located inwardly of the upstanding wall with the inner and outer walls forming a double walled arrangement inwardly of the upstanding wall for providing lateral cushioning to contents of the enclosure in use, with the outer wall being seated against the inner surface of the upstanding wall of the enclosure; and

placing the enclosure containing the instrument into a steriliser and exposing the enclosure to a sterilising gas such that said gas permeates the enclosure and sterilises the instrument contained therein.

US Pat. No. 11,109,934

SYSTEM, METHOD, AND APPARATUS FOR REMOTE PATIENT CARE

DEKA Products Limited Par...


1. A portable patient-care kit, comprising:two-housing portions pivotally coupled together to form a container space;
a plurality of compartments disposed within at least one of the two-housing portions, each compartment configured to retain at least one medical apparatus;
a central control unit comprising a touch-screen user interface device having a transceiver configured to communicate via a mobile data network; and
a plurality of lights, each of the plurality of lights being configured to supply light within a separate one of each of the plurality of compartments,
wherein a compartment of the plurality of compartments includes a door, wherein the touch-screen user interface device is in operative communication with the door to instruct the door to automatically open, and
wherein the central control unit is configured to illuminate the plurality of lights so as to illuminate the plurality of compartments and the at least one medical apparatus retained therein in a sequence of operation, the control unit configured to automatically illuminate a next compartment in the sequence of operation based on data from at least one of the at least one medical apparatus.

US Pat. No. 11,109,933

DEVICES FOR SUPPORTING A MEDICAL INSTRUMENT AND METHODS OF USE


1. A medical instrument support device, the device comprising: a base comprising: a central base portion; a first, elongated base extension protruding from the central base portion along at least a portion of a first axis; and a second, elongated base extension protruding from the central base portion along at least a portion of a second axis, the first and second axes being in a base plane that extends through the central base portion, and the first and second axes intersecting through the central base portion and being at an angle of greater than 00 and less than 1800 to each other; a grasper for receiving a medical instrument; and a flexible elongated neck portion having a first end and a second end, wherein the first end is coupled with the grasper and the second end is coupled with the base, wherein a position of the first end of the flexible elongated neck portion relative to the base is adjustable, wherein the base has a first side and a second side, the first side being proximal to the second end of the flexible elongated neck portion and the second side being distal to the second end of the flexible elongated neck portion, at least a portion of the second side lying in a plane that is parallel to the base plane, and wherein at least a portion of the second side of the base portion comprises an adhesive coating, wherein the grasper comprises: a first grasper portion and a second grasper portion, the first and second grasper portions each having an inner surface and an outer surface, the inner surface and the outer surface of each of the first and second grasper portions being spaced apart and opposite each other, wherein the inner surfaces of the first and second grasper portions face each other; and a central grasper portion coupling the first and second grasper portions, wherein the central grasper portion includes an arcuate shaped portion that extends between the first and second grasper portions, wherein: the first grasper portion extends along a first grasper axis and the second grasper portion extends along a second grasper axis, the first and second grasper axes lying within a grasper plane that extends through the central grasper portion, and distal ends of the first and second grasper portions are spaced apart from the central grasper portion along the first and second grasper axes, respectively, the distal ends of the first and second grasper portions being biased toward each other into a first position and urgable away from each other into a second position, and the medical instrument is receivable between portions of the inner surfaces adjacent the distal ends of the first and second grasper portions, wherein each of the first and second grasper portions comprises an engagement portion that is spaced apart from the distal end of the respective first and second grasper portions along the respective grasper axis, the central grasper portion is coupled to the first and second grasper portions at an intermediate portion of each of the first and second grasper portions, wherein the intermediate portion of each of the first and second grasper portions is disposed between the distal end and the engagement portion of the respective first or second grasper portion along the respective grasper axis, the engagement portions are urgable toward each other to urge the distal ends of the first and second grasper portions away from each other, and the arcuate shaped portion of the central grasper portion has a continuous concave surface, as viewed from the distal ends of the first and second grasper portion, that extends between the first grasper portion and the second grasper portion.

US Pat. No. 11,109,932

SURGICAL DRAPE INCLUDING A LAYER TO PROTECT THE OPERATOR FROM SCATTERED RADIATION DURING CARDIOLOGIC AND RADIOLOGIC INVASIVE PROCEDURES


1. A method for shielding an operator from radiation during a coronary intervention procedure of a patient with X-ray imaging comprising spreading a sterile surgical drape over the patient to provide shielding,wherein the sterile surgical drape comprises an integrated radio-protective layer that does not move independently from the sterile surgical drape and that does not lie in the path of the primary X-ray beam during the coronary intervention procedure,
wherein the sterile surgical drape is at least 130 cm in width and at least 130 cm in length,
wherein the integrated radio-protective layer is at least 130 cm in width, and
wherein the integrated radio-protective layer is at least 60 cm in length,
wherein the integrated radio-protective layer comprises at least one precut hole that can be opened to allow access to the patient; and
performing the coronary intervention procedure with X-ray imaging,
wherein the sterile surgical drape reduces the cumulative dose of the operator of the coronary intervention procedure to 0-5 ?Sv when accessed through the right radial artery.

US Pat. No. 11,109,931

MULTI-LAYER PRE-DRAPE APPARATUS AND PROCESS

Work Fluidics, LLC, San ...


1. A multi-layered pre-drape comprising:a lower layer with an aperture;
a middle layer having a flat section that surrounds the aperture and a folded drape section surrounds the flat section of the middle layer wherein the folded drape section is expandable from a folded configuration into an unfolded configuration that drapes outward;
an upper layer that is a sterile cover that covers the middle layer, the lower layer, and the aperture which are sterile, wherein the upper layer covers the folded drape section and holds the folded drape section in place;
a first adhesive that is configured to secure a lower surface of the lower layer to a patient with a surgical area within the aperture of the lower layer; and
a second adhesive that secures a lower surface of the upper layer to an upper surface of the lower layer and an upper surface of the flat section of the middle layer wherein an adhesive strength of the first adhesive is greater than the second adhesive.

US Pat. No. 11,109,930

ENHANCED HAPTIC FEEDBACK SYSTEM

COVIDIEN LP, Mansfield, ...


1. An enhanced haptic feedback system for medical diagnostics, comprising:a laparoscope configured to be inserted into a body cavity to view tissue, the laparoscope configured to obtain an image of the viewed tissue;
an imaging device configured to acquire physiological data about tissue, process the acquired physiological data, and output the processed data to a graphical user haptic interface (GUHI) capable of generating tangible sensations utilizing one or more haptic interfaces, the GUHI configured to receive the image from the laparoscope, combine the image received from the laparoscope and the processed physiological data received from the imaging device, and provide tangible sensations on both a front screen of the GUHI and a rear screen of the GUHI allowing a surgeon the sensation of feeling for abnormal tissue conditions between the surgeon's hands.

US Pat. No. 11,109,929

MEDICAL TOOL GRIP MECHANISM WHICH GRIPS AND CONTROLS MEDICAL TOOL

MEDICAROID CORPORATION, ...


1. A medical tool grip mechanism which is configured to grip a medical tool including a shaft extending in a longitudinal axis of the shaft, a treatment tool arranged on a side of one end portion of the shaft in the longitudinal axis of the shaft, and a treatment tool control portion which is arranged on a side of the other end portion of the shaft in the longitudinal axis of the shaft and controls the treatment tool, the medical tool grip mechanism comprising:a gripping portion which is provided at a distal end of a manipulator arm, is rotatably supported by a drive shaft provided orthogonal to the longitudinal axis of the shaft so as to be rotatable between a grip position and a released position with respect to the manipulator arm about the drive shaft and is configured to grip the treatment tool control portion in such a manner that the treatment tool control portion is movable in the longitudinal axis of the shaft when the gripping portion is being rotated about the drive shaft of the gripping portion,
wherein the gripping portion includes a space for gripping the treatment tool control portion in the grip position, the space having a longitudinal axis thereof extending along a radial axis of the drive shaft in the grip position and having first and second ends along the longitudinal axis of the space such that, when the gripping portion is rotated about the drive shaft from the grip position to the released position, the treatment tool control portion in the space is moved toward the first end of the space along the longitudinal axis of the space while the longitudinal axis of the space of the gripping portion is rotated with respect to the longitudinal axis of the shaft, and
the medical tool grip mechanism is configured to couple the treatment tool control portion of the medical tool to the gripping portion at the grip position in such a manner that the treatment tool control portion is located in the space of the gripping portion and thus gripped by the gripping portion and is configured to decouple the treatment tool control portion of the medical tool from the gripping portion at the released position in such a manner that the treatment tool control portion comes out of the space of the gripping portion from a side of the first end of the space of the gripping portion.

US Pat. No. 11,109,928

MEDICAL INSTRUMENTS INCLUDING WRISTS WITH HYBRID REDIRECT SURFACES

Auris Health, Inc., Redw...


1. A medical instrument, comprising:a shaft extending between a proximal end and a distal end;
a wrist positioned at the distal end of the shaft, the wrist comprising:a proximal clevis connected to the distal end of the shaft,
a distal clevis pivotally connected to the proximal clevis, the distal clevis configured to rotate about a pitch axis,
a plurality of proximal pulleys configured to rotate about the pitch axis, and
a plurality of distal pulleys configured to rotate about a yaw axis; and

an end effector connected to the plurality of distal pulleys;
a plurality of pull wires engaged with the plurality of proximal pulleys and the plurality of distal pulleys and configured to articulate the wrist and actuate the end effector, wherein the plurality of pull wires comprise at least:a first pull wire segment having a first cable path length extending from a first proximal pulley of the plurality of proximal pulleys to a first distal pulley of the plurality of distal pulleys, and
a second pull wire segment having a second cable path length extending from a second proximal pulley of the plurality of proximal pulleys to the first distal pulley,
wherein the first cable path length is less than the second cable path length.


US Pat. No. 11,109,927

JOINT DRIVING ACTUATOR AND MEDICAL SYSTEM

SONY CORPORATION, Tokyo ...


1. A joint driving actuator comprising:an ultrasonic motor configured to generate driving force for driving a joint, the ultrasonic motor including a stator fixed to a side of one arm that relatively rotates in the joint and a rotor fixed to a side of another arm that relatively rotates in the joint, the stator including a piezoelectric element that generates ultrasonic vibration;
a torque sensor configured to detect external force applied to the joint; and
an encoder configured to detect a rotational angle of the ultrasonic motor, wherein
the encoder is mouthed on the one arm the stator being fixed on the side thereof, and
the torque sensor is mounted on the another arm, the rotor being fixed on the side thereof.

US Pat. No. 11,109,926

ROBOTIC SURGICAL ASSEMBLIES AND SURGICAL INSTRUMENT HOLDERS THEREOF

Covidien LP, Mansfield, ...


1. A surgical instrument holder, comprising:a carriage configured for movable engagement to a surgical robotic arm; and
a drive coupler including:an outer member extending from the carriage, the outer member defining a lateral slot therein configured for lateral receipt of a surgical instrument;
a first gear defining a lateral slot therein and being rotatable within the outer member to a first position, in which the lateral slot of the first gear is in alignment with the lateral slot of the outer member such that the surgical instrument is receivable within the drive coupler through the lateral slots of the outer member and the first gear;
a second gear operably coupled with the first gear and configured to be drivingly rotated by an instrument drive unit to effect rotation of the first gear relative to the outer member; and
an inner member including:an internal housing rotatably disposed within the outer member, the internal housing having the first gear non-rotatably disposed therein;
an upper plate fixed to a first side of the internal housing and supported on and extending over an upper surface of the outer member; and
a lower plate fixed to a second side of the internal housing and supported on and extending over a lower surface of the outer member such that the outer member is captured between the upper and lower plates.



US Pat. No. 11,109,925

ARTICULATABLE MEMBERS HAVING CONSTRAINED MOTION AND RELATED DEVICES AND METHODS

INTUITIVE SURGICAL OPERAT...


1. An articulatable member, comprising:a plurality of links extending in a series from a proximal end link to a distal end link, adjacent links of the plurality of links being pivotably coupled to form joints between adjacent links;
an actuation member extending from the proximal end link to the distal end link,wherein the actuation member is operably coupled to the plurality of links to transmit force to bend the articulatable member from a neutral position; and

a constraint member extending from the proximal end link to the distal end link,wherein the constraint member has opposite ends that are fixed to the distal end link and the proximal end link, respectively,
wherein the constraint member extends through a throughhole in each link of the plurality of links, the throughhole being radially offset from a central axis of the link, and
wherein the constraint member follows a helical path along at least a portion of the articulatable member from the proximal end link to the distal end link;

wherein, in a straight configuration of the articulatable member, the constraint member is under tensile force between the opposite ends.

US Pat. No. 11,109,924

SYSTEM AND METHODS FOR POSITIONING A MANIPULATOR ARM BY CLUTCHING WITHIN A NULL-PERPENDICULAR SPACE CONCURRENT WITH NULL-SPACE MOVEMENT

Intuitive Surgical Operat...


1. A method of operating a robotic system comprising a manipulator arm, the manipulator arm comprising a distal portion configured to support an instrument, a proximal portion coupled to a base, and a plurality of joints between the distal portion and the base, wherein the plurality of joints provide sufficient degrees of freedom to allow a range of differing joint states of the plurality of joints for a given state of the distal portion, the method comprising:when the robotic system is in a manipulation mode, driving the plurality of joints to move an end effector of the instrument while pivoting the instrument about a remote center; and
when the robotic system is in a first clutch mode, concurrently:servoing the plurality of joints in a first joint velocity space, wherein movement of the plurality of joints in the first joint velocity space moves a remote center,
floating the plurality of joints in a second joint velocity space, wherein movement of the plurality of joints in the second joint velocity space moves the end effector, and
controlling motion of the plurality of joints within a third joint velocity space, wherein movement of the plurality of joints in the third joint velocity space does not move the end effector and does not move the remote center.


US Pat. No. 11,109,923

TROCAR HOLDER

avateramedical GmbH, Jen...


1. A trocar holder for a manipulator of a robotic surgical system, comprising:a base element for securing the trocar holder to the manipulator;
a clamp element which is replaceably connected to the base element via a coupling mechanism and on which two limbs, connected via a spine, movable relative to each other in a clamp plane and with free tips are formed;
a clamp mechanism for opening and closing the limbs; and
a receiving element for a trocar; a radial-axial bearing is formed in an area of the tips of each of the two limbs; the receiving element is formed as an axle and has a continuous opening perpendicular through the axle to feed the trocar through; wherein the receiving element is prevented from moving axially by the radial-axial bearings when the limbs are closed.

US Pat. No. 11,109,922

SURGICAL TOOL SYSTEMS AND METHOD

Globus Medical, Inc., Au...


1. A medical robot system, comprising:a robot coupled to an end-effector, the robot configured for controlled movement and positioning of the end-effector, the end-effector including a guide tube;
a motor assembly coupled to the robot, the motor assembly being configured to move the end-effector along one or more of an x-axis, a y-axis, and a z-axis;
a surgical instrument positionable within the guide tube, the surgical instrument including at least one detectable feature which is reflective; and
a detection device configured and arranged to detect the reflection of light from the at least one detectable feature,
wherein a depth of the surgical instrument in the guide tube is determined by the at least one detectable feature,
wherein the at least one detectable feature includes at least one reflective marker having a radius of curvature terminating at a substantially flat collar or flange.

US Pat. No. 11,109,921

INTERLOCKING SYSTEM AND METHOD FOR JOYSTICKS IN A CATHETER PROCEDURE SYSTEM

Corindus, Inc., Waltham,...


11. A catheter procedure system comprising:a bedside system comprising a percutaneous device and at least one drive mechanism coupled to the percutaneous device; and
a workstation coupled to the bedside system, the workstation comprising:an input device configured to generate a first voltage output signal based on a physical activation of the input device;

an input device cover disposed over the input device and comprising a first portion having an electrode plating on the first portion;
a capacitive touch detection circuit coupled to the input device cover, the capacitive touch detection circuit mounted on a second portion of the input device cover and configured to detect a proximal change in capacitance in the electrode plating of the first portion of the input device cover and to generate a touch output signal to indicate whether a change in capacitance has been detected; and
a signal enable circuit coupled to the input device and the capacitive touch detection circuit, the signal enable circuit configured to generate an enable voltage output based on whether a change in capacitance has been detected.

US Pat. No. 11,109,919

OCCLUSION TRAVERSAL ROBOTIC CATHETER SYSTEM

Corindus, Inc., Waltham,...


1. A robotic catheter procedure system, comprising:a bedside system, the bedside system comprising:a first percutaneous device;
a second percutaneous device;
a first actuating mechanism configured to engage and to impart movement to the first percutaneous device; and
a second actuating mechanism configured to engage and to impart movement to the second percutaneous device; and

a remote workstation, the remote workstation comprising:a user interface; and
a control system operatively coupled to the user interface and to the bedside system, the control system controlling:the first actuating mechanism to cause movement of the first percutaneous device; and
the second actuating mechanism to cause movement of the second percutaneous device;
the control system configured to provide movement of the first percutaneous device and the second percutaneous device by operation of a single input control,
wherein operation of the single input control during advancement of the first percutaneous device controls movement of both the first percutaneous device and the second percutaneous device such that the relative motion between the first percutaneous device and the second percutaneous device is substantially zero.



US Pat. No. 11,109,918

SYSTEM AND METHOD FOR A DEEP TISSUE MASSAGER


16. A therapeutic massage device communication system comprising:a plurality of therapeutic massage devices that are separate from each other, each of a first therapeutic massage device and a second therapeutic massage device, in the plurality, being configured to a device configuration selected from the following:a manually operated motorized therapeutic massage device, or
a motorized therapeutic massage device communicatively coupled to and disposed upon a robotically controlled system;

and wherein
each of the first therapeutic massage device and the second therapeutic massage device comprising:a computer-controlled electrical motor having a motor drive shaft that is rotationally driven by the computer-controlled electrical motor;
a contact surface arrangement being coupled to the motor drive shaft by means of a rigid transfer member having an offset hub coupled to the motor drive shaft, the offset hub being directly coupled and rotationally coupled to a bearing assembly and thereby rotationally coupled to the contact surface arrangement, a center axis of the motor drive shaft at the offset hub being offset from a center axis of the offset hub which is coincident to a center axis of the contact surface arrangement, and wherein the motor drive shaft at the offset hub, the rigid transfer member, the offset hub, and the bearing assembly, collectively disposed within an enclosure, and wherein the motor drive shaft is coupled to the contact surface arrangement to rotationally drive and impart rotational motion to the contact surface arrangement and thereby treat a body of a user with therapeutic massage;
at least one sensor including a rotational motion sensor for sensing rotational motion of the contact surface arrangement; and
a computer controller, communicatively coupled with the computer-controlled electrical motor, the at least one sensor, and a computer network; and wherein
the computer controller, responsive to executing computer instructions, being adapted to perform the following operations:determining a configured pre-set value for rotational motion revolutions per minute (RPM) for the contact surface arrangement individualized to the user for treating the user's body with a same therapeutic massage by either the first therapeutic massage device or the second therapeutic massage device, wherein the determining the configured pre-set value being performed by the computer controller by at least one of:accessing data stored in the respective each therapeutic massage device, the data corresponding to the configured pre-set value; or
accessing data corresponding to the configured pre-set value by network communication with a computer system communicatively coupled to the computer network;

controlling, with the computer controller, the computer-controlled electrical motor, to rotationally impart rotational motion to the contact surface arrangement based on the configured pre-set value for rotational motion revolutions per minute (RPM); and
communicating, with the computer controller, data corresponding to sensor data from the at least one sensor, over the computer network, to the computer system communicatively coupled to the computer network, wherein the computer system includes one or more of: a robotically controlled system, a computer, a smart phone, or another of the first therapeutic massage device or the second therapeutic massage device.



US Pat. No. 11,109,917

INTEGRATED SURGERY METHOD AND SYSTEM

MAKO Surgical Corp., Ft....


1. A system for conducting a procedure in an operating room, comprising:a first camera-based 3-D motion sensor mounted in a known position and orientation in a global coordinate system of the operating room and configured to generate signals related to the 3-D position of an object in the operating room based upon a shape of the object relative to the first camera-based 3-D motion sensor; and
a controller operatively coupled to the first camera-based 3-D motion sensor and configured to:define a predetermined operational plan comprising a plurality of positions of the object over time;
assign a desired time milestone within the procedure for each position of the object in the predetermined operational plan;
automatically monitor progress of the procedure based at least in part upon one or more positions of the object over time, the one or more positions based at least in part upon the signals from the first camera-based 3-D motion sensor;
compare the one or more positions of the object over time with the desired time milestone within the procedure for each position of the object in the predetermined operational plan;
record data relating to an actual time for each position of the object in the predetermined operational plan compared with the desired time milestone; and
use the data during or after the procedure to provide a recommendation for a change to a future predetermined operational plan.


US Pat. No. 11,109,916

PERSONALIZED HAND-EYE COORDINATED DIGITAL STEREO MICROSCOPIC SYSTEMS AND METHODS

DIGITAL SURGICALS PTE LTD...


1. A personalized digital microscope system for use in microsurgery, comprising:a camera system comprising an array of camera pairs, each camera pair configured to produce a stereo pair of images captured in real-time;
an image processing system communicatively coupled to the camera system and configured to extract the stereo pair of images, captured by a camera pair, synchronized in time with each other and to combine the stereo pair of images with encoded images of differences between the stereo pair of images; and
a video processing system communicatively coupled to the image processing system and configured to create a stream from the encoded images of the camera pair by processing the encoded images based on parameters to personalize the processing by the video processing system for the user,
wherein the parameters are determined based on a test procedure performed by the user,
wherein the parameters for the user are stored for use by the video processing system during the processing of the encoded images and for use by the image processing system to select the camera pair from the array of camera pairs based thereon, and
wherein the parameters obtained from the test procedure relate to at least one of the stereo acuity of the user, ocular muscle abilities of the user, interpupillary distance of the user, and a dominant eye of the user.

US Pat. No. 11,109,915

METHOD AND DEVICE FOR NAVIGATING ACTIVE SURGICAL INSTRUMENTS

Fiagon GmbH, Hennigsdorf...


1. A method for detecting a location and operating state of a surgical instrument, the surgical instrument having an active operating state and an inactive state, the surgical instrument emitting or influencing a first electromagnetic field when in the active operating state, comprising the following method steps:positioning a first sensor for detecting the first electromagnetic field emanating from, or influenced by, the surgical instrument when in the active operating state thereof at a known location;
detecting by means of the first sensor the first electromagnetic field emanating from, or influenced by, the surgical instrument in the active operating state thereof;
generating an output signal by the first sensor, the output signal indicating the detection by the first sensor of the first electromagnetic field emanating from, or influenced by, the surgical instrument in the active operating state;
establishing the location and the operating state of the surgical instrument in the active operating state on the basis of the output signal and the known location of the first sensor, and generating location data, the location data corresponding to the established location;
generating a second alternating electromagnetic field by a field generator,
arranging an instrument sensor at the surgical instrument so as to detect said second alternating electromagnetic field generated by the field generator, and
generating an induced current dependent on a position of the instrument sensor, and evaluating the induced current so as to determine a position of the surgical instrument relative to a patient when the surgical instrument is in the inactive state and therefore when the surgical instrument is not emitting or influencing said first electromagnetic field.