US Pat. No. 11,027,033

STERILIZING APPARATUS

SEOUL VIOSYS CO., LTD., ...

1. A portable sterilizing apparatus comprising:a housing having an outer surface facing a target region and an inner surface opposite to the outer surface;
a cover body having a portion with a curved shape and coupled to the housing to define a space inside the housing and cover an upper portion of the housing;
an irradiation opening disposed on the inner surface of the housing to face the target region;
a window member receiving portion disposed on the inner surface of the housing around the irradiation opening, the window member receiving portion surrounding the irradiation opening;
a window member received by the window member receiving portion;
a light source disposed on a substrate in the housing and configured to emit light toward the target region through the irradiation opening;
a power supply configured to supply power to the light source to turn on the light source;
a detection unit disposed over the substrate and configured to detect status of the cover body; and
a control unit configured to control the power supply based on a detection result of the detection unit,
wherein the irradiation opening has a diameter allowing at least 50% of the light emitted from the light source to pass therethrough.

US Pat. No. 11,027,032

SYSTEMS, METHODS, AND DEVICES FOR STERILIZING ANTISEPTIC SOLUTIONS

CAREFUSION 2200, INC., S...

1. A sterile antiseptic solution comprising:an antimicrobial molecule selected from the group consisting of: an octenidine salt and a biguanide; and
an alcohol solvent,
wherein the sterile antiseptic solution is sterile and at least about 92% pure,
wherein the sterile antiseptic solution is made sterile by a method comprising the steps of:
providing a container containing an antiseptic solution, the antiseptic solution having an initial purity;
selecting a sterilization temperature from about 85° C. to about 135° C. and a sterilization time from about 1 minute to about 19 hours;
heating the antiseptic solution to the selected sterilization temperature;
maintaining the antiseptic solution at the sterilization temperature for the selected sterilization time; and
terminating the heating of the antiseptic solution when the selected sterilization time expires, thereby providing the sterile antiseptic solution,
wherein after terminating the heating, the sterile antiseptic solution has a post-sterilization purity, and
wherein the sterilization temperature and the sterilization time are selected such that after terminating the heating, the sterile antiseptic solution has a post-sterilization purity of at least about 92% and a percentage point change in purity from the initial purity to the post-sterilization purity of at most about 5%.

US Pat. No. 11,027,029

PEPTIDE THIOUREA DERIVATIVE, RADIOISOTOPE LABELED COMPOUND CONTAINING SAME, AND PHARMACEUTICAL COMPOSITION CONTAINING SAME AS ACTIVE INGREDIENT FOR TREATING OR DIAGNOSING PROSTATE CANCER

Cellbion Co., Ltd, Seoul...

1. A compound represented by formula 1 below or a pharmaceutically acceptable salt of the same:
wherein
X is single bond;
n is an integer of 3;
Y is —N(CH2COOH)(CH2)aCH2CH2—,
m is an integer of 1 or 2; and
a, b and c are independently an integer of 0 or 1.

US Pat. No. 11,027,028

MANGANESE COMPLEXES WITH SUBSTITUTED BISPHOSPHONATES USEFUL AS IMAGING AND THERAPEUTIC AGENTS

Duke University, Durham,...

1. A compound useful as a magnetic resonance imaging (MRI) contrast agent and a therapeutic agent, said compound having a structure represented by:Y—X—Z
wherein,
X is Mn(II), and Y and Z are each independently a bisphosphonate of the formula:

wherein:
R1 is —OH,
R2, R3, R4, R5 and R6 are each independently H, alkyl, or -LR?, wherein at least one of R2, R3, R4, R5 and R6 is -LR?,
wherein each L is present or absent and when present is a linking group, and
wherein each R? is independently a therapeutic agent,
or a pharmaceutically acceptable hydrate thereof,
wherein said compound has a stoichiometry of 1:2 (Mn(II): bisphosphonate),
wherein said compound is a salt comprising at least one alkali metal and at least one alkaline earth metal, and
wherein the contrast agent has a molecular weight of less than 2,000 daltons.

US Pat. No. 11,027,027

PYRIDAZINOINDOLE COMPOUNDS AND METHODS FOR PET IMAGING

Vanderbilt University, N...

1. A compound of the following formula:
wherein R1 and R2 are independently ethyl; and n is 8.

US Pat. No. 11,027,026

POLYMER, AND CONTRAST AGENT FOR PHOTOACOUSTIC IMAGING, INCLUDING THE POLYMER

CANON KABUSHIKI KAISHA, ...

1. A polymer represented by formula (A1):
wherein in the formula (A1), R0 represents a residue derived from a cationic polymerization initiator, or a functional group; L1 represents a linker and L1 may not be present; D1 is represented by formula (d1-1); and Z1 represents a structure comprising at least one unit represented by formula (A2), at least one unit represented by formula (A3), and at least one unit represented by formula (A4):

wherein in the formula (A2), D2 is represented by the formula (d1-1); and R1 to R4 each independently represents a hydrogen atom, or a substituted or unsubstituted hydrocarbon group having 1 to 4 carbon atoms, in which, when a substituent is present, the substituent is a functional group including at least one selected from the group consisting of a halogen atom, an oxygen atom and a nitrogen atom;

wherein in the formula (A3), R1 to R4 each independently represents a hydrogen atom, or a substituted or unsubstituted hydrocarbon group having 1 to 4 carbon atoms, in which, when a substituent is present, the substituent is a functional group including at least one selected from the group consisting of a halogen atom, an oxygen atom, and a nitrogen atom; and
R5 represents any of a methyl group, an ethyl group, an isopropyl group, a n-propyl group, a n-butyl group, a n-octyl group, a n-heptyl group, a phenyl group, a butenyl group, and a pentynyl group;

wherein in the formula (A4), R1 to R4 each independently represents a hydrogen atom, or a substituted or unsubstituted hydrocarbon group having 1 to 4 carbon atoms, in which, when a substituent is present, the substituent is a functional group including at least one selected from the group consisting of a halogen atom, an oxygen atom, and a nitrogen atom, and
wherein a ratio of a unit represented by the formula (A4) to repeating units of the polymer is 12.6% or less as measured by electric conductivity:

wherein, in the formula (d1-1), * represents binding to L1 in the formula (A1) or represents binding to Z1 in the formula (A1) when L1 is not present.

US Pat. No. 11,027,022

CONJUGATES AND CONJUGATING REAGENTS

POLYTHERICS LIMITED, Cam...

1. A conjugate of a protein or peptide conjugated to a therapeutic agent via a linker, in which the linker also includes a cyclodextrin, and in which the cyclodextrin is present as a pendant group which is tethered to the backbone of the linker, wherein the conjugate is represented schematically by the formula:in which:D represents said therapeutic agent,
F? represents a group of formula I:
in which Pr represents said protein or peptide, each Nu represents a sulfur atom or amine group present in or attached to the protein or peptide, each of A and B independently represents a C1-4alkylene or alkenylene chain, and W? represents a keto group —CO—, an ester group —O—CO—, a sulfone group —SO2—, or a group obtained by reduction of one of these groups; and CD represents said cyclodextrin.

US Pat. No. 11,027,021

COMBINATIONS OF PBD-BASED ANTIBODY DRUG CONJUGATES WITH BCL-2 INHIBITORS

Seagen Inc., Bothell, WA...

1. A method of treating cancer in a subject in need of such treatment, the method comprising administering an antibody drug conjugate (ADC) and a Bcl-2 inhibitor, wherein the ADC comprises an antibody conjugated to a PBD cytotoxic agent, wherein the Bcl-2 inhibitor is selected from the group consisting of ABT-199 and ABT-263, and wherein the antibody is selected from the group consisting of:a) an anti-CD33 antibody comprising the light chain variable region of SEQ ID NO: 1 and the heavy chain variable region of SEQ ID NO: 2; and
b) and anti-CD19 antibody comprising the light chain variable region of SEQ ID NO: 10 and the heavy chain variable region of SEQ ID NO: 11.

US Pat. No. 11,027,019

METHODS OF MAKING ANTIMICROBIAL BIOPOLYMER FROM SODIUM ALGINATE AND ALGAE EXTRACT USING AMINOGLYCOSIDES, AND METHODS OF USING THE SAME

1. A polymer, comprising:a sodium alginate; and
an aminoglycoside, wherein the polymer is used to heal a wound.

US Pat. No. 11,026,993

CYCLIC TETRAMER COMPOUNDS AS PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9 (PCSK9) INHIBITORS FOR THE TREATMENT OF METABOLIC DISORDERS

Novartis AG, Basel (CH)

1. A compound of Formula (I):
wherein:
X1 and X2 are each independently H or (C1-C6)alkyl, or X1 and X2 together with the carbon atom to which they are attached form ?(O);
X3 is —CH2— when X1 and X2 are each independently H or (C1-C6)alkyl, or X1 and X2 together with the carbon atom to which they are attached form ?(O), or X3 is —O—, —NH— or —N(C1-C6)alkyl-, when X1 and X2 together with the carbon atom to which they are attached form ?(O);
R1 is (C6-C10)aryl or 5- or 6-membered heteroaryl comprising 1-3 heteroatoms selected from N, O, and S, wherein the aryl and heteroaryl are substituted with —OR10 or —NR21R10 and optionally substituted with one or more R11;
R2 is H, (C1-C6)alkyl, (C2-C6)alkenyl, (C1-C6)haloalkyl, —NR12R13, (C3-C7)carbocyclyl, (C3-C7)cycloalkenyl, 5- to 7-membered heterocyclyl comprising 1-3 heteroatoms selected from N, O, and S, (C6-C10)aryl, or 5- or 6-membered heteroaryl comprising 1-3 heteroatoms selected from N, O, and S, wherein the alkyl is optionally substituted with one or more R18, and the carbocyclyl, (C3-C7)cycloalkenyl, heterocyclyl, aryl and heteroaryl are optionally substituted with one or more R19;
R3 is H, D, (C1-C6)alkyl, (C1-C6)alkoxy, (C1-C6)haloalkyl, (C1-C6)haloalkoxy, or (C1-C6)hydroxyalkyl, wherein the alkyl is optionally substituted with one or more R14;
R4 is H or (C1-C6)alkyl; or
R3 and R4 together with the atoms to which they are attached form a 5- to 7-membered heterocyclyl ring comprising 1-3 heteroatoms selected from N, O, and S;
R5 and R7 are each independently H, D, (C1-C6)alkyl, (C1-C6)alkoxy, (C1-C6)haloalkyl, (C1-C6)haloalkoxy, or (C1-C6)hydroxyalkyl, wherein the (C1-C6)alkyl is optionally substituted with one or more D;
R6 is (C1-C6)alkyl, (C1-C6)alkoxy, (C1-C6)haloalkyl, (C1-C6)haloalkoxy, or (C1-C6)hydroxyalkyl, wherein the alkyl is optionally substituted with one or more substituents each independently selected from (C1-C6)alkoxy, (C1-C6)haloalkoxy, —C(O)(C1-C6)alkyl, —C(O)OH, and —C(O)O(C1-C6)alkyl;
R8 is H, (C1-C6)alkyl, or (C1-C6)haloalkyl, wherein the alkyl is optionally substituted with one or more substituents each independently selected from (C3-C7)carbocyclyl, 4- to 7-membered heterocyclyl comprising 1-3 heteroatoms selected from N, O, and S, —NR16R17, and —C(O)NR16R17;
R9 is halogen, (C1-C6)alkyl, (C1-C6)alkoxy, (C1-C6)haloalkyl, (C1-C6)haloalkoxy, —OH, or CN;
R10 is (C6-C10)aryl or 5- or 6-membered heteroaryl comprising 1-3 heteroatoms selected from N, O, and S, wherein the aryl and heteroaryl are optionally substituted with one or more R22;
each R11 is independently at each occurrence halogen, (C1-C6)alkyl, (C1-C6)alkoxy, (C1-C6)haloalkyl, (C1-C6)haloalkoxy, —OH, or CN;
R12 and R13 are each independently H or (C1-C6)alkyl;
each R14 is independently at each occurrence D, NR15R15?, (C3-C7)carbocyclyl, or 3- to 7-membered heterocyclyl comprising 1-3 heteroatoms selected from N, O, and S, wherein the carbocyclyl and heterocyclyl are optionally substituted with one or more substituents each independently selected from halogen, (C1-C6)alkyl, (C1-C6)alkoxy, (C1-C6)haloalkyl, and (C1-C6)haloalkoxy;
R15 and R15? are each independently H or (C1-C6)alkyl;
R16 and R17 are each independently H or (C1-C6)alkyl, or
R16 and R17 together with the nitrogen atom to which they are attached form a 4- to 7-membered heterocyclyl ring optionally comprising 1-2 additional heteroatoms selected from N, O, and S;
each R18 is independently at each occurrence (C3-C7)carbocyclyl, 5- to 7-membered heterocyclyl comprising 1-3 heteroatoms selected from N, O, and S, (C6-C10)aryl, or 5- or 6-membered heteroaryl comprising 1-3 heteroatoms selected from N, O, and S, wherein the carbocyclyl, heterocyclyl, aryl and heteroaryl are optionally substituted with one or more R20;
each R19 is independently at each occurrence halogen, (C1-C6)alkyl, (C1-C6)alkoxy, (C1-C6)haloalkyl, (C1-C6)haloalkoxy, —OH, or CN; or
two R19 together, when on adjacent atoms, form a (C6-C10)aryl or 5- or 6-membered heteroaryl ring comprising 1-3 heteroatoms selected from N, O, and S, wherein the aryl and heteroaryl are optionally substituted with one or more substituents each independently selected from halogen, (C1-C6)alkyl, (C1-C6)alkoxy, (C1-C6)haloalkyl, (C1-C6)haloalkoxy, —OH, and CN;
each R20 is independently at each occurrence halogen, (C1-C6)alkyl, (C1-C6)alkoxy, (C1-C6)haloalkyl, (C1-C6)haloalkoxy, oxo, —OH, or CN; or
when R18 a carbocyclyl or a heterocyclyl, two R20, when attached to the same carbon atom, together form ?(O);
R21 is H or (C1-C6)alkyl;
each R22 is independently at each occurrence halogen, (C1-C6)alkyl, (C1-C6)alkoxy, (C1-C6)haloalkyl, (C1-C6)haloalkoxy, —OH, CN, (C6-C10)aryl, or 5- or 6-membered heteroaryl comprising 1-3 heteroatoms selected from N, O, and S, wherein the aryl and heteroaryl are optionally substituted with one or more R23;
each R23 is independently at each occurrence halogen, (C1-C6)alkyl, (C1-C6)alkoxy, (C1-C6)haloalkyl, (C1-C6)haloalkoxy, —CH2(OCH2CH2)1-3OCH2CH3, —OH, CN, or 4- to 7-membered heterocyclyl comprising 1-3 heteroatoms selected from N, O, and S, wherein the heterocyclyl is optionally substituted with one or more substituents each independently selected from halogen, (C1-C6)alkyl, (C1-C6)alkoxy, (C1-C6)haloalkyl, (C1-C6)haloalkoxy, —OH, —C(O)R24R25, —NR24C(O)R25, —NH2, —NH(C1-C6)alkyl, and —N((C1-C6)alkyl)2, and the alkyl is optionally substituted with —NR24R25 or a 4- to 7-membered heterocyclyl comprising 1-3 heteroatoms selected from N, O, and S optionally substituted with one or more substituents each independently selected from halogen, (C1-C6)alkyl, (C1-C6)alkoxy, (C1-C6)haloalkyl, (C1-C6)haloalkoxy, —OH, —NH2, —NH(C1-C6)alkyl, and —N((C1-C6)alkyl)2; and
R24 and R25 are each independently H, (C1-C6)alkyl, or (C3-C7)carbocyclyl optionally substituted with one to two (C1-C6)alkyl;
or a pharmaceutically acceptable salt, hydrate, solvate, prodrug, stereoisomer, N-oxide, or tautomer thereof.

US Pat. No. 11,026,987

COMPOSITION FOR REMEDYING FEMALE CLIMACTERIC SYNDROME SYMPTOMS

1. A method for treating or remedying female climacteric syndrome symptoms by administering to a subject in need thereof a therapeutically effective amount of a composition comprising an extract of buds of Pueraria thomsonii.

US Pat. No. 11,026,981

LDL-CHOLESTEROL-LOWERING CELL EXTRACT AND FOOD SUPPLEMENT

ezCol B.V., Rosmalen (NL...

1. An extract of Rhodospirillum rubrum that is obtained by extracting R. rubrum with a solvent mixture of petroleum ether and methanol containing sodium chloride, wherein the petroleum ether has boiling point between 60° C. and 80° C. wherein the R. rubrum is extracted for a period of time between 10 minutes and 48 hours at a temperature between 8° C. and 37° C., while mixing the R. rubrum cells with the solvent mixture, and wherein the ratio of petroleum ether to methanol comprising sodium chloride in a solvent mixture is between 10:1 and 1:10.

US Pat. No. 11,026,968

ANTICOAGULATION FLUID COMPRISING CITRATE AND PHOSPHATE

Gambro Lundia AB, Lund (...

1. A single compartment bag comprising an anticoagulation fluid for regional citrate anticoagulation in an extracorporeal blood circuit, wherein the anticoagulation fluid in the single compartment bag comprises 18-40 mM basic citrate; 0.1-5 mM acid citrate; 0.5-1.5 mM total calcium; and 0.1-3 mM phosphate, the anticoagulation fluid having a pH between 7.4 and 8.

US Pat. No. 11,026,965

NITRIC OXIDE-RELEASING CYCLODEXTRINS AS BIODEGRADABLE ANTIBACTERIAL SCAFFOLDS AND METHODS PERTAINING THERETO

The University of North C...

1. A functionalized cyclodextrin represented by the following structure:
wherein
n is an integer selected from 1 to 8;
m is an integer from 0 to 7;
each instance of R1 is represented by —X1—((CH2)f?X2)g?((CH2)qX3)r—(CH2)h?H;
wherein
each of f?, q, g?, r, and h? is independently selected from an integer from 0 to 4;
each instance of X1, X2, or X3 is independently selected from O, NH, or a nitric oxide donating substituent; and at least one instance of X1, X2, or X3 in said functionalized cyclodextrin is

US Pat. No. 11,026,963

SENOLYTIC COMPOSITIONS AND USES THEREOF

Rubedo Life Sciences, Inc...

1. A compound having the structure:
or pharmaceutically acceptable salts, hydrates or solvates thereof.

US Pat. No. 11,026,960

ESTERS OF 2-DEOXY-MONOSACCHARIDES WITH ANTI PROLIFERATIVE ACTIVITY

Board of Regents, The Uni...

1. A method of treating brain or pancreatic cancer in a patient in need thereof comprising administering a therapeutically effective amount of one or more compounds of the Formula I:
or a salt thereof, wherein:
each R1, R2, R3 and R4 are independently H, or C(O)R5;
at least two of R1, R2, R3 and R4 is C(O)R5; and
each R5 is independently selected from C3-C7 straight- or branched-chain alkyl, C4-C10 alkylcycloalkyl, and C3-C7 cycloalkyl.

US Pat. No. 11,026,958

SUBSTITUTED 6-MEMBERED ARYL OR HETEROARYL ALLOSTERIC MODULATORS OF NICOTINIC ACETYLCHOLINE RECEPTORS

1. A compound having the formula I:or a pharmaceutically acceptable salt thereof, wherein:X is selected from

Y is 4 substituents, each independently selected from H, (C1-C4)alkyl, halogen, and OH, wherein said alkyl is optionally substituted with one or more halogen or OH;
A is a 6-membered heteroaryl ring which is substituted with 1 to 4 R groups each independently selected from OH, oxo, amino, amido, carboxyl, keto, cyano, alkoxy, S(O)m-alkyl, halogen, aminoalkyl, hydroxyalkyl, alkyl, cycloalkyl, alkynyl, aryl, heteroaryl, and heterocyclyl, wherein said amino, amido, carboxyl, keto, alkoxy, S(O)m-alkyl, aminoalkyl, hydroxyalkyl, alkyl, cycloalkyl, alkynyl, aryl, heteroaryl and heterocyclyl are optionally substituted with one or more substituents independently selected from halogen, OH, oxo, CF3, OCF3, CN, (C1-C6)alkyl, O(C1-C4)alkyl, S(O)m—(C1-C4)alkyl, C?O(C1-C4)alkyl, (C?O)NR7R8, (C?O)OR7, (C2-C4)alkynyl, (C3-C6)cycloalkyl, O(C3-C6)cycloalkyl, C?O(C3-C6)cycloalkyl, aryl, heteroaryl and heterocyclyl, wherein said alkyl, aryl, heteroaryl and heterocyclyl are optionally independently substituted with one or more halogen, CF3, OH and oxo;
R1 is H or (C1-C4)alkyl;
R2 is H or (C1-C4)alkyl;
R3 is H, halogen, Si(CH3)3 or (C1-C4)alkyl, wherein said alkyl is optionally substituted with one or more halogen;
R4 is H, halogen or (C1-C4)alkyl, wherein said alkyl is optionally substituted with one or more halogen;
or, R3 and R4 optionally can come to together to form a cyclopropyl, cyclobutyl, cyclopentyl or cyclohexyl ring wherein said ring may be optionally substituted with one or more substituents independently selected from OH, halogen, or (C1-C4)alkyl;
R5 is H or (C1-C4)alkyl;
R6 is H or (C1-C4)alkyl;
R7 and R8 are independently selected from H, (C1-C6)alkyl, cycloalkyl, aryl, heteroaryl and heterocyclyl, wherein said alkyl, cycloalkyl, aryl, heteroaryl and heterocyclyl are optionally substituted with one or more substituents independently selected from halogen, OH, CF3, (C1-C4)alkyl, O(C1-C4)alkyl, cycloalkyl, CN, aryl, heteroaryl, and heterocyclyl, wherein said alkyl, cycloalkyl, aryl, heteroaryl and heterocyclyl are optionally substituted with one or more substituents independently selected from halogen, OH, CF3, (C1-C4)alkyl, O(C1-C4)alkyl, CN;
Ra is H or (C1-C4)alkyl;
Rb is H or (C1-C4)alkyl; and
m is 0, 1, or 2.

US Pat. No. 11,026,955

SYNTHETIC BILE ACID COMPOSITIONS AND METHODS

Allergan Sales, LLC, Mad...

1. A method for emulsifying fat in a mammal in need thereof, the method comprising administering locally to said mammal a composition comprising: a therapeutically effective amount of DCA
or a pharmaceutically acceptable salt thereof, wherein the DCA comprises a synthetic side chain of formula:

and at least one pharmaceutically acceptable excipient and/or carrier.

US Pat. No. 11,026,954

3-BETA-HYDROXY-5-ALPHA-PREGNAN-20-ONE FOR USE IN MEDICAL TREATMENT

ASARINA PHARMA AB, Solna...

1. A method of treating Tourette's syndrome, obsessive compulsive disorder and/or gambling disorder, comprising administering a pharmaceutically effective amount of 3beta-hydroxy-5alpha-pregnan-20-one, to a patient in need thereof.

US Pat. No. 11,026,951

METHODS OF TREATING BIPOLAR DISORDER

INTRA-CELLULAR THERAPIES,...

1. A method for the treatment of bipolar disorder I and/or bipolar II disorder comprising administering to a patient in need thereof an effective amount of a Compound of Formula I:
wherein:
X is —N(CH3)— and Y is —C(O)—;
in free or pharmaceutically acceptable salt form, wherein said Compound is not used in combination with another antipsychotic agent.

US Pat. No. 11,026,950

METHODS AND COMPOSITIONS FOR TREATING MESOTHELIOMA AND SMALL LUNG CANCER THAT EXPRESS MIDKINE

1. A method of treating malignant mesothelioma, comprising the step of administering to an individual in need thereof, an effective amount of a pharmaceutical composition comprising a compound selected from
or a pharmaceutically acceptable salt thereof, and a pharmaceutical carrier.

US Pat. No. 11,026,949

COMBINATION THERAPY FOR TREATING CANCER

Epizyme, Inc., Cambridge...

1. A method for treating clear cell renal cell carcinoma in a patient in need thereof comprising administering a therapeutically effective amount of an EZH2 inhibitor and one or more tyrosine kinase inhibitors, wherein the EZH2 inhibitor is GSK-126 having the following formula:
or a pharmaceutically acceptable salt thereof;
or
a compound of Formula (I):

or a pharmaceutically acceptable salt thereof;
wherein:
R701 is H, F, OR707, NHR707, —(C?C)—(CH2)n7-R708, phenyl, 5- or 6-membered heteroaryl, C3-8 cycloalkyl, or 4-7 membered heterocycloalkyl containing 1-3 heteroatoms, wherein the phenyl, 5- or 6-membered heteroaryl, C3-8 cycloalkyl or 4-7 membered heterocycloalkyl each independently is optionally substituted with one or more groups selected from halo, C1-3 alkyl, OH, O—C1-6 alkyl, NH—C1-6 alkyl, and, C1-3 alkyl substituted with C3-8 cycloalkyl or 4-7 membered heterocycloalkyl containing 1-3 heteroatoms, wherein each of the O—C1-6 alkyl and NH—C1-6 alkyl is optionally substituted with hydroxyl, O—C1-3 alkyl or NH—C1-3 alkyl, each of the O—C1-3 alkyl and NH—C1-3 alkyl being optionally further substituted with O—C1-3 alkyl or NH—C1-3 alkyl alkyl;
each of R702 and R703, independently is H, halo, C1-4 alkyl, C1-6 alkoxyl or C6-C10 aryloxy, each optionally substituted with one or more halo;
each of R704 and R705, independently is C1-4 alkyl;
R706 is cyclohexyl substituted by N(C1-4 alkyl)2 wherein one or both of the C1-4 alkyl is substituted with C1-6 alkoxy; or R706 is tetrahydropyranyl;
R707 is C1-4 alkyl optionally substituted with one or more groups selected from hydroxyl, C1-4 alkoxy, amino, mono- or di-C1-4 alkylamino, C3-8 cycloalkyl, and 4-7 membered heterocycloalkyl containing 1-3 heteroatoms, wherein the C3-8 cycloalkyl or 4-7 membered heterocycloalkyl each independently is further optionally substituted with C1-3 alkyl;
R708 is C1-4 alkyl optionally substituted with one or more groups selected from OH, halo, and C1-4 alkoxy, 4-7 membered heterocycloalkyl containing 1-3 heteroatoms, or O—C1-6 alkyl, wherein the 4-7 membered heterocycloalkyl can be optionally further substituted with OH or C1-6 alkyl; and
n7 is 0, 1 or 2.

US Pat. No. 11,026,948

PLATINUM-RESISTANT CANCER TREATMENT

BTG INTERNATIONAL LIMITED...

1. A method of treating ovarian cancer that is platinum refractory or resistant in a patient in need thereof comprising administering to the patient in need thereof a compound of formula Ior a pharmaceutically acceptable salt or ester thereof wherein(i) the treatment is with a dose of from 8 mg/m2 to 15 mg/m2 of compound per patient body surface area per administration, and
(ii) the treatment is administered by infusions of the dose, wherein the infusions are spaced from 10 to 21 days apart.

US Pat. No. 11,026,947

ALK2 INHIBITORS AND METHODS FOR INHIBITING BMP SIGNALING

The United States of Amer...

1. A compound of formula (I):or a pharmaceutically acceptable salt and/or prodrug thereof, whereinA1 is NR4a or CR4bR5;
B1 is N or CR2;
Z1 is N or CR3;
R1 is selected from cycloalkyl, aryl, heteroaryl, and heterocyclyl;
R2 is H, CN, NO2, alkyl, or amino;
R3 is selected from H, CN, NO2, alkyl, alkoxy, heterocyclyloxy, heteroaryloxy, aryloxy, cycloalkyloxy, carbonyl, amino, amido, sulfonyl, sulfonamido, cycloalkyl, aryl, heterocyclyl, and heteroaryl;
R4a is selected from alkyl, alkenyl, alkynyl, carbonyl, O?, alkoxycarbonyl, cycloalkyl, aryl, heterocyclyl, and heteroaryl;
R4b is selected from halo, CN, NO2, hydroxy, alkyl, alkenyl, alkynyl, alkoxy, heterocyclyloxy, heteroaryloxy, aryloxy, cycloalkyloxy, amino, amido, carbonyl, alkoxycarbonyl, carboxy, sulfonyl, sulfonamido, thio, cycloalkyl, aryl, heterocyclyl, and heteroaryl;
R5 is selected from H, halo, hydroxy and alkyl, or
R4b and R5 together with A1 form a ring selected from cycloalkyl and heterocyclyl;
each R6 is independently selected from H, halo, CN, NO2, hydroxy, alkyl, alkenyl, alkynyl, alkoxy, heterocyclyloxy, heteroaryloxy, aryl oxy, cycloalkyloxy, amino, amido, carbonyl, alkoxycarbonyl, carboxy, sulfonyl, sulfonamido, thio, cycloalkyl, aryl, heterocyclyl, and heteroaryl and oxo;
n is 0 or 1;
m is 0 or 1; and
x is 0, 1, 2, 3, or 4.

US Pat. No. 11,026,946

PHARMACOLOGICALLY ACTIVE ALICYCLIC-SUBSTITUTED PYRAZOLO[1,5-A]PYRIMIDINE DERIVATIVES

RICHTER GEDEON NYRT., Bu...

1. A compound of formula (I) wherein:
R1 and R2 are independently selected from hydrogen, halogen atom, C1-6alkyl, or haloC1-6alkyl;
R3 is hydrogen, halogen atom, C1-6alkyl, or cyano group;
R4 is C1-6alkyl;
R5 is C1-6alkyl optionally substituted by a halogen atom, halogen atoms, C3-5 cycloalkyl; C3-5 cycloalkylC1-6alkyl, dialkylamino, C1-6alkoxy, C1-6alkoxyC1-6alkyl, C1-6alkylthio group, tetrahydrofuranyl, tetrahydrofuranylC1-6alkyl, tetrahydropyranyl, or tetrahydropyranylC1-6alkyl;
or R4 and R5 together form a 3 to 7-membered saturated ring, wherein the 3 to 7-membered saturated ring is unsubstituted or substituted by one or more C1-3alkyl, C1-3alkoxy, haloC1-3alkyl, or C1-3alkylcarbonyl, and wherein the members of the ring are selected from the group consisting of carbon, nitrogen, oxygen, and sulphur;
R6 is hydrogen, halogen atom, C1-6alkyl, hydroxyl, C1-6alkoxy, C1-6alkoxyC1-6alkyl, haloC1-6alkyl, or an amino group; or pharmaceutically acceptable salts, hydrolysable esters, racemates, enantiomers, diastereomers, solvates and hydrates thereof.

US Pat. No. 11,026,944

COMPOSITIONS AND METHODS FOR TREATING INSOMNIA

1. A dosage form comprising a therapeutically effective amount of compound A, wherein said therapeutically effective amount is a single daily dose ranging from about 2.5 mg to about 10 mg, wherein said dosage form provides a dissolution rate of 85% or more in a dissolution medium (0.1 mol/L hydrochloric acid containing 0.5% polysorbate 80, 900 mL, 37±0.5° C.) within 30 minutes from the onset of a dissolution study using Apparatus 2 (Paddle Apparatus, paddle speed; 75 rpm) according to the procedure for immediate-release dosage form in 6.10 Dissolution test of JP16 or <711>Dissolution of USP37, wherein said compound A is (1R,2S)-2-(((2,4-dimethylpyrimidin-5-yl)oxy)methyl)-2-(3-fluorophenyl)-N-(5-fluoropyridine-2-yl)cyclopropanecarboxamide represented by the following formula:

US Pat. No. 11,026,943

AMINOQUINOLINE DERIVATIVES AND USES THEREOF

The McLean Hospital Corpo...

1. A method of ameliorating symptoms of Parkinson's disease, the method comprising administering to a subject in need thereof a therapeutically effective amount of a compound selected from the group consisting of Formula (1)-Formula (X) and any pharmaceutically acceptable salt, hydrate, solvate, ester, stereoisomer mixture, or enantiomer thereof, where
wherein:
X, Y, and Z are independently CR18, N, O, or S;
Z1 is N and Z2 is CR14;
R16 is chlorine;
R10-R15 and R17-R18 are independently H, linear or branched alkyl, linear or branched alkenyl, linear or branched alkynyl, cyclyl, heterocyclyl, aryl, heteroaryl, halogen, trifluoromethyl, alkoxy, nitro, cyano, carbonyl, hydroxyl, phenoxy, amino, alkylamino, thiol, or alkylthio, each of which can be optionally substituted; and
L is a linker

wherein:
X and Y are independently CR18, N, O, or S;
A and B are independently CR18, N, O, or S;
Z1 is N and Z2 is CR14;
R16 is chlorine;
R11-R15 and R17-R18 are independently H, linear or branched alkyl, linear or branched
alkenyl, linear or branched alkynyl, cyclyl, heterocyclyl, aryl, heteroaryl, halogen, trifluoromethyl, alkoxy, nitro, cyano, carbonyl, hydroxyl, phenoxy, amino, alkylamino, thiol, or alkylthio, each of which can be optionally substituted;
----- forms a cyclyl, heterocyclyl, aryl, or heteroaryl, each of which can be optionally substituted; and
L is a linker;

wherein:
A and B are independently CR18 or N;
Z1 is N and Z2 is CR14;
R16 is chlorine;
R, R10-R15 and R17-R18 are independently H, linear or branched alkyl, linear or branched alkenyl, linear or branched alkynyl, cyclyl, heterocyclyl, aryl, heteroaryl, halogen, trifluoromethyl, alkoxy, nitro, cyano, carbonyl, hydroxyl, phenoxy, amino, alkylamino, thiol, or alkylthio, each of which can be optionally substituted; and
L is a linker;

wherein:
X and Z are independently CR18, N, O, or S;
Z1 is N and Z2 is CR14;
R16 is chlorine;
R11-R15 and R17-R18 are independently H, linear or branched alkyl, linear or branched alkenyl, linear or branched alkynyl, cyclyl, heterocyclyl, aryl, heteroaryl, halogen, trifluoromethyl, alkoxy, nitro, cyano, carbonyl, hydroxyl, phenoxy, amino, alkylamino, thiol, or alkylthio, each of which can be optionally substituted;
----- forms a cyclyl, heterocyclyl, aryl, or heteroaryl, each of which can be optionally substituted; and
L is a linker;

wherein:
X, Y, and Z are independently CR18, N, O, or S;
Z1 is N and Z2 is CR14;
R16 is chlorine; and
R11-R15 and R17-R18 are independently H, linear or branched alkyl, linear or branched alkenyl, linear or branched alkynyl, cyclyl, heterocyclyl, aryl, heteroaryl, halogen, trifluoromethyl, alkoxy, nitro, cyano, carbonyl, hydroxyl, phenoxy, amino, alkylamino, thiol, or alkylthio, each of which can be optionally substituted; and
R10 is linear or branched alkyl, linear or branched alkenyl, linear or branched alkynyl, cyclyl, heterocyclyl, aryl, heteroaryl, halogen, trifluoromethyl, alkoxy, nitro, cyano, carbonyl, hydroxyl, phenoxy, amino, alkylamino, thiol, or alkylthio, each of which can be optionally substituted;

wherein:
X, Y, and Z are independently CR18, N, O, or S;
R27 is chlorine;
R10, R11, R18, R21-R26 and R28 are independently H, linear or branched alkyl, linear or branched alkenyl, linear or branched alkynyl, cyclyl, heterocyclyl, aryl, heteroaryl, halogen, trifluoromethyl, alkoxy, nitro, cyano, carbonyl, hydroxyl, phenoxy, amino, alkylamino, thiol, or alkylthio, each of which can be optionally substituted; and
L is a linker;

wherein:
X, Y, and Z are independently CR18, N, O, or S;
Z1 is N and Z2 is CR14;
R16 is chlorine; and
R10-R15 and R17-R22 are independently H, linear or branched alkyl, linear or branched alkenyl, linear or branched alkynyl, cyclyl, heterocyclyl, aryl, heteroaryl, halogen, trifluoromethyl, alkoxy, nitro, cyano, carbonyl, hydroxyl, phenoxy, amino, alkylamino, thiol, or alkylthio, each of which can be optionally substituted;

wherein:
X, Y, and Z are independently CR18, N, O, or S;
Z1 is N and Z2 is CR14;
R16 is chlorine; and
R10-R15 and R17-R21 are independently H, linear or branched alkyl, linear or branched alkenyl, linear or branched alkynyl, cyclyl, heterocyclyl, aryl, heteroaryl, halogen, trifluoromethyl, alkoxy, nitro, cyano, carbonyl, hydroxyl, phenoxy, amino, alkylamino, thiol, or alkylthio, each of which can be optionally substituted;

wherein:
X, Y, and Z are independently CR18, N, O, or S;
Z1 is N and Z2 is CR14;
R16 is chlorine; and
R10-R15 and R17-R22 are independently H, linear or branched alkyl, linear or branched alkenyl, linear or branched alkynyl, cyclyl, heterocyclyl, aryl, heteroaryl, halogen, trifluoromethyl, alkoxy, nitro, cyano, carbonyl, hydroxyl, phenoxy, amino, alkylamino, thiol, or alkylthio, each of which can be optionally substituted;

wherein:
R is hydrogen, CH3, Cl, CF3 or CN;
R1 is cyclic or acylic amine; and
L is an optionally substituted C2-C30 alkyl, optionally substituted aromatic ring, optionally substituted heteroaryl ring, saturated cyclic ring; amino acid, or peptide.

US Pat. No. 11,026,937

HETEROARYL INHIBITORS OF PAD4

Padlock Therapeutics, Inc...

1. A compound of formula I or formula II:or a pharmaceutically acceptable salt thereof, wherein:R1 is S(CH3),

R2 is hydrogen or optionally substituted C1-6-aliphatic;
L is

R3 is

R4 is R or C(O)OR;
each R is independently hydrogen or Ci-6 aliphatic optionally substituted with 1-3 fluorine atoms;
R5 is hydrogen or CN;
Rx and Ry are taken together with their intervening atoms to form a optionally substituted 5-6 membered saturated, partially unsaturated, or aromatic fused ring having 1-2 heteroatoms independently selected from nitrogen, oxygen, or sulfur.

US Pat. No. 11,026,936

PIPERIDINYL-PROPANONE DERIVATIVES

Merck Patent GmbH, Darms...

1. A compound of the formula I
in which
X denotes NH or O,
Q denotes C(CH3)2 or 1,1-cyclopropylene,
R1 denotes H, A, Cyc, Ar or Het,
R2 denotes H or CH3,
R3 denotes H or A?,
Ar denotes phenyl, which is unsubstituted or mono-, di- or trisubstituted by Hal, NO2, CN, A, OR3, S(O)mR3, N(R3)2, COA, COOR3, CON(R3)2, SO2N(R3)2, NR3COR3, NR3SO2A and/or NR3CON(R3)2,
Het denotes a mono- or bicyclic saturated, unsaturated or aromatic heterocycle having 1 to 4 N, O and/or S atoms, which is unsubstituted or mono- or disubstituted by Hal, NO2, CN, A, OR3, S(O)mR3, N(R3)2, COA, COOR3, CON(R3)2, SO2N(R3)2, NR3COR3, NR3SO2A and/or NR3CON(R3)2,
A denotes unbranched or branched alkyl with 1-10 C-atoms, wherein one or two non-adjacent CH- and/or CH2-groups may be replaced by N-, O- and/or S-atoms and/or wherein 1-7 H-atoms may be replaced by R4,
R4 denotes F, Cl or OH,
A? denotes unbranched or branched alkyl with 1-6 C-atoms, wherein 1-5 H-atoms may be replaced by F,
Cyc denotes cyclic alkyl with 3, 4, 5, 6 or 7 C-atoms, which is unsubstituted or monosubstituted by OH,
Hal denotes F, Cl, Br or I,
m denotes 0, 1 or 2,
and pharmaceutically acceptable salts, tautomers and stereoisomers thereof, including mixtures thereof in all ratios.

US Pat. No. 11,026,935

FREE BASE CRYSTALLINE FORM OF A COMPLEMENT COMPONENT C5A RECEPTOR

ChemoCentryx, Inc., San ...

1. A free base crystalline form of Compound 1characterized by an X-ray powder diffraction (XRPD) pattern comprising peaks at 8.1, 8.4, 14.1, 16.9, and 19.0 degrees 2? (±0.2 degrees 2?).

US Pat. No. 11,026,934

TOPICAL RETINOID COMPOSITIONS

1. A topical lotion composition, comprising:a) a retinoid compound;
b) an oil phase comprising one or more water immiscible substances;
c) a hydrophilic phase comprising water;
d) a thickener;
e) one or more dermatologically acceptable excipient; and
f) one or more surfactants in the range from about 0.01% w/w to about 10% w/w of the total weight of the composition;
wherein the composition is free of propellant, and wherein the composition has pH from about 4 to about 7; wherein the composition excludes peanut oil.

US Pat. No. 11,026,933

COMPOSITIONS AND METHODS FOR TREATMENT OF CANCER

1. A method of treating a proliferative disorder due to increased expression of the FOXM1 gene, comprising the step of administering a composition comprising
or a pharmaceutically acceptable salt thereof;
and a pharmaceutically acceptable excipient.

US Pat. No. 11,026,932

MEDICINAL COMPOSITION FOR PREVENTING OR TREATING INFLAMMATORY RESPIRATORY DISEASE

NATIONAL UNIVERSITY CORPO...

1. A method for treating an inflammatory respiratory disease, comprising administering an effective amount of RXR agonist as an active ingredient, wherein the inflammatory respiratory disease is emphysema or bronchial asthma wherein the RXR agonist is a compound represented by Formula (1)
wherein D is selected cMe2, N-ethyl N-isopropyl;
R1 is selected from a methyl group, a hydroxy group, a methoxy group or an ethoxy group,
R2 is selected from H, a methyl group or an ethyl group;
X is selected from N, CH or C—CF3,
Y is selected from N or CH;
Z is CH.

US Pat. No. 11,026,928

COMPOSITIONS AND METHODS FOR TREATING CONDITIONS RELATED TO ELEVATED LEVELS OF EOSINOPHILS AND/OR BASOPHILS

Knopp Biosciences LLC, P...

1. A method of treating a gastrointestinal disease associated with increased eosinophils comprising administering to a subject in need thereof a therapeutically effective amount of dexpramipexole, or a pharmaceutically acceptable salt thereof, wherein the gastrointestinal disease associated with increased eosinophils is selected from the group consisting of sclerosing cholangitis, irritable bowel disease, ulcerative colitis, eosinophilic esophagitis, eosinophilic gastroenteritis, inflammatory bowel disease, eosinophilic colitis, gluten sensitivity, Cronkhite-Canada syndrome, and any combination thereof.

US Pat. No. 11,026,926

SUBSTITUTED BICYCLIC COMPOUNDS AS BROMODOMAIN INHIBITORS

Zenith Epigenetics Ltd., ...

1. A method for treating a cancer in a mammal, comprising administering to said mammal a therapeutically effective amount of a compound of formula:
or a tautomer, pharmaceutically acceptable salt, or hydrate thereof,
wherein:
D1 is isoxazole, optionally substituted with one or more groups independently selected from deuterium, alkyl(C1-C4), alkoxy(C1-C4), amino, halogen, amide, —C(O)cycloamino, —CF3, CN, —N3, —S(O)Alkyl(C1-C4), —SO2alkyl(C1-C4), -thioalkyl(C1-C4), —COOH, and ester,
wherein said alkyl(C1-C4), alkoxy(C1-C4), amino, amide, —S(O)Alkyl(C1-C4), —SO2alkyl(C1-C4), -thioalkyl(C1-C4), and ester are optionally substituted with one or more groups independently selected from hydrogen, F, Cl, Br, —OH, —NH2, —NHMe, —OMe, —SMe, oxo, and thio-oxo;
X is present and selected from —(NH)—, —O—, —NHCRxRy—, —NHSO2—, and —CRxRyNH—;
Z1 is —NRa;
Ra is selected from hydrogen, deuterium, and alkyl(C1-3);
R3 is selected from isoxazole, pyrazole, pyridyl, thiazole, isothiazole, pyrimidine, phenyl, cyclohexene, benzo[d]oxazolyl, naphthyl, and quinolyl, optionally substituted with one or more groups independently selected from deuterium, alkyl(C1-C4), —OH, alkoxy(C1-C4), amino, halogen, amide, —CF3, CN, —N3, —S(O)Alkyl(C1-C4), —SO2alkyl(C1-C4), C4), carboxyl, and ester,
wherein said alkyl(C1-C4), alkoxy(C1-C4), amino, amide, —S(O)Alkyl(C1-C4), —SO2alkyl(C1-C4), -thioalkyl(C1-C4), and ester are optionally substituted with one or more groups independently selected from hydrogen, F, Cl, Br, —OH, —NH2, —NHMe, —OMe, —SMe, oxo, and thio-oxo;
R1 and R2 are independently selected from hydrogen, deuterium, alkyl, —OH, —NH2, -thioalkyl, and alkoxy; and
Rx and Ry are each independently selected from hydrogen, alkyl(C1-5), halogen, —OH, —CF3, deuterium, amino, and alkoxy(C1-5), or two substituents selected from Rx, Ry, and R1 may be connected in a 5- or 6-membered ring to form a bicyclic carbocycle or bicyclic heterocycle,
and wherein said cancer is selected from B-acute lymphocytic leukemia, Burkitt's lymphoma, diffuse large cell lymphoma, multiple myeloma, primary plasma cell leukemia, atypical carcinoid lung cancer, bladder cancer, breast cancer, cervix cancer, colon cancer, gastric cancer, glioblastoma, hepatocellular carcinoma, large cell neuroendocrine carcinoma, medulloblastoma, melanoma, neuroblastoma, esophageal cancer, osteosarcoma, ovarian cancer, renal carcinoma, retinoblastoma, rhabdomyosarcoma, small cell lung carcinoma, NUT midline carcinoma, B-cell lymphoma, non-small cell lung cancer, head and neck squamous cell carcinoma, chronic lymphocytic leukemia, follicular lymphoma, diffuse large B cell lymphoma with germinal center phenotype, Hodgkin's lymphoma, activated anaplastic large cell lymphoma, primary neuroectodermal tumor, pancreatic cancer, adenoid cystic carcinoma, T-cell prolymphocytic leukemia, malignant glioma, thyroid cancer, Barrett's adenocarcinoma, hepatoma, pro-myelocytic leukemia, and mantle cell lymphoma.

US Pat. No. 11,026,924

1H-PYRAZOLO[4,3-B]PYRIDINES AS PDE1 INHIBITORS

1. A compound of formula (I):
or a pharmaceutically acceptable salt thereof, wherein:
L is NH;
R1 is methyl;
R2 is 2-butyl;
R3 is methyl substituted with a 5-membered heteroaryl which is substituted with methyl; and
R4 is pyridinyl which is substituted with C1-C3 alkoxy.

US Pat. No. 11,026,923

1H-PYRAZOLO[4,3-B]PYRIDINES AS PDE1 INHIBITORS

1. A compound of formula (I):
or a pharmaceutically acceptable salt thereof, wherein:
L is NH;
R1 is H or C1-C5 alkyl;
R2 is C1-C4 alkyl;
R3 is methyl substituted with a 5-membered heteroaryl which is substituted with methyl, or is methyl substituted with a pyridinyl which is substituted with C1-C3 fluoroalkyl or C1-C3 alkoxy; and
R4 is pyridinyl which is substituted with C1-C3 alkoxy.

US Pat. No. 11,026,919

FORMULATION FOR SOFT ANTICHOLINERGIC ANALOGS

BODOR LABORATORIES, INC.,...

1. An anhydrous topical gel composition comprising:(a) a compound having the formula:

said compound having the R stereoisomeric configuration at the 2 position and the R, S or RS stereoisomeric configuration at the 1? and 3? positions, or being a mixture thereof;
(b) anhydrous ethanol;
(c) at least one gelling or viscosity-controlling ingredient comprising hydroxypropyl cellulose;
(d) citric acid;
(e) hexylene glycol;
(f) isopropyl myristate; and
(g) optionally, at least one additional carrier or excipient;
provided that said anhydrous topical gel composition comprises from about 1% to about 25% w/v or w/w of the compound of formula (2), said composition having greater storage stability compared to a composition comprising an aqueous solvent or aqueous buffer.

US Pat. No. 11,026,917

ANTIOXIDATIVE STRESS COMPOSITIONS, METHODS OF PREPARING AND USES THEREOF

1. A dietary supplement comprising at least three active agents selected from the group consisting of resveratrol, genistein, curcumin, quercetin, and salts thereof, wherein the at least three active agents are in an amount that provides a decrease in plasma level of IL-2 after oral or intravenous administration of the dietary supplement to a mammal for three weeks, whereinthe decrease in plasma level of IL-2 is below 0.4 ng/ml,
resveratrol comprises from about 1% to about 80% of the dietary supplement by weight, and
the dietary supplement, after said administration, provides a serum level of resveratrol of from about 3.86 ng/ml to about 154 ?g/ml.

US Pat. No. 11,026,911

METHOD OF DIETARY TREATMENT FOR GENETIC AND EPIGENETIC DISEASES AND DISORDERS

1. A method for treating a trinucleotide repeat disorder in a subject in need thereof, the method comprising orally administering to the subject about 375 mg to about 15,000 mg of acetate per day, wherein said acetate is provided as a composition comprising magnesium acetate, calcium acetate, or ethylacetate; wherein administration of the composition increases acetylation of histone H3K9 and/or histone H3K14 in the subject.

US Pat. No. 11,026,910

?- AND ?-TRUXILLIC ACID DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS THEREOF

The Research Foundation f...

1. A mixture of compounds having the structure:
wherein the mixture is enantiomerically enriched in a compound having the structure:

wherein
one of R1 or R2 is —C(?O)OR13,
wherein R13 is substituted C1-10 alkyl, C2-10 alkenyl or C2-10 alkynyl; and
the other of R1 or R2 is —C(?O)OH,
wherein the substituted C1-10 alkyl is substituted with halogen, alkoxy, heteroaryloxy, sulfonyl, nitro, mercapto, sulfanyl, cyano, amino, carbamoyl, carboxyl or acyl;
R3, R4, R5, R6, R7, R8, R9, R10, R11 and R12 are each independently, H, halogen, —NO2, —CN, —NHR15, —OR15 or CF3;
wherein R15 is H, C1-10 alkyl, C2-10 alkenyl or C2-10 alkynyl;
or a pharmaceutically acceptable salt thereof.

US Pat. No. 11,026,908

EXTENDED RELEASE DOSAGE FORMS OF PREGABALIN

MAPI PHARMA LTD., Ness Z...

1. An oral, extended-release (ER) pharmaceutical composition comprising as an active ingredient pregabalin or a salt thereof and a pharmaceutically acceptable carrier or excipient, wherein the composition comprises a first component that provides pH independent controlled release of the pregabalin active ingredient over a time period of about 4 to about 6 hours, and a second component that provides pH independent controlled release of the pregabalin active ingredient over a time period of about 24 hours,wherein the first component and the second component are each in the form of ER beads or mini-tablets that are filled into hard or soft gelatin capsules or compressed into dispersible tablets,
wherein the mini-tablets or ER beads of the first component are uncoated, and wherein the mini-tablets or ER beads of the second component are coated.

US Pat. No. 11,026,905

STAT3 INHIBITORS

Tvardi Therapeutics, Inc....

1. A pharmaceutical composition, comprising(a) a compound of Formula III,

or a pharmaceutically acceptable salt thereof, and
(b) a pharmaceutically acceptable carrier or diluent.

US Pat. No. 11,026,904

MITOFUSIN ACTIVATORS AND METHODS OF USE THEREOF

Mitochondria Emotion, Inc...

1. A method comprising:administering a therapeutically effective amount of a composition comprising one or more of a mitofusin activator or a pharmaceutically acceptable salt thereof to a subject having or suspected of having a mitochondria-associated disease, disorder or condition, the mitofusin activator having a formula of

wherein:
X is

Z is optionally substituted phenyl;
Ra and Rb are independently H, F, alkyl, or C3-7 cycloalkyl, or Ra and Rb taken together form a C3-7 cycloalkyl or heterocycloalkyl;
Rc and Rd are independently H, F, alkyl, CORg, or C3-7 cycloalkyl, or Rc and Rd taken together form a C3-7 cycloalkyl or heterocycloalkyl;
Y is 0, CH2, cyclopropyl, or cyclobutyl;
Rg is H, alkyl, or C3-7 cycloalkyl;
o is 0 or 1;
p is 1; and
q is 1, 2, 3, or 4, provided that if Y is cyclopropyl or cyclobutyl, the sum of o+p+q is not less than 3 or greater than 5 and otherwise the sum of o+p+q is 5.

US Pat. No. 11,026,903

METHODS AND COMPOSITIONS FOR TREATMENT OF PAIN USING CAPSAICIN

Centrexion Therapeutics C...

1. A method of ameliorating joint pain in a human patient, comprising:a. optionally applying a cooling article to a human patient's skin in proximity to a joint in need of pain relief therapy; then
b. optionally administering a local anesthetic agent into said joint; then
c. applying a cooling article to the patient's skin in proximity to said joint to achieve a temperature in the range of from 28° C. to 30° C. for tissue or fluid in the interior of the joint; then
d. administering by injection into said joint 2 mL of a pharmaceutical composition comprising capsaicin in order to deliver a dose of capsaicin in an amount of 1 mg; and then
e. optionally applying a cooling article to the patient's skin in proximity to said joint; to thereby ameliorate joint pain in the human patient,
wherein the joint pain is osteoarthritic joint pain, the joint is a knee joint, and after administration of the pharmaceutical composition comprising capsaicin in step (d) but prior to step (e) said joint is flexed 5 times; and
the following additional step is performed between steps (c) and (d):
administering into said joint 15 mL of a pharmaceutical composition comprising a single pain-relief local anesthetic agent selected from the group consisting of lidocaine and a pharmaceutically acceptable salt thereof, in order to deliver a dose of lidocaine in an amount ranging from about 0.1 g to about 0.5 g;
wherein other than administration of (i) a local anesthetic agent and (ii) the pharmaceutical composition comprising capsaicin, the patient does not receive any other pain-relief medicine.

US Pat. No. 11,026,902

TOPICAL COMPOSITION AND DELIVERY SYSTEM AND ITS USE

SAMBRIA PHARMACEUTICALS, ...

1. A topical delivery system comprising a pharmaceutical composition formulated for application directly to a skin of a subject in need thereof, comprising:(a) a therapeutic amount of an amino benzoate local anesthetic agent;
(b) chemical drivers comprising ethoxydiglycol, propylene glycol, and methylsulfonylmethane (MSM), wherein the chemical drivers are cooperatively effective to deliver the amino benzoate local anesthetic agent into skin; and
(c) a depot component that is effective to keep the aminobenzoate local anesthetic agent locally in the skin and to reduce distribution of the aminobenzoate local anesthetic agent to the blood stream, wherein the depot component is selected from the group consisting of a liposome, a polymer, a polymersome, and a combination thereof.

US Pat. No. 11,026,894

LIPID NANOPARTICLES AND USE THEREOF TO DELIVER RNA POLYNUCLEOTIDES

Massachusetts Institute o...

1. A lipid nanoparticle comprising 1,2-dioleoyl-3-trimethylammonium propane (DOTAP), 1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC), cholesterol, and 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[amino(polyethylene glycol)-2000] (DSPE-PEG2000), wherein the molar ratio of DOTAP: DSPC: cholesterol: DSPE-PEG2000 is 40:10:48:2.

US Pat. No. 11,026,892

MINIMIZING AGGLOMERATION OF DRUG PARTICLE COATING MATERIAL DURING STORAGE TO STABILIZE DISINTEGRATION TIMES OF PHARMACEUTICAL PRODUCTS

Catalent U.K. Swindon Zyd...

1. A method of preparing a pharmaceutical composition comprising:mixing active pharmaceutical ingredient (“API”) particles with a coating material comprising one or more deformable components;
exposing the mixture of API particles and coating material to mechanical and thermal energy to deform the one or more deformable components and form coated API particles;
mixing the coated API particles with silica;
exposing the mixture of coated API particles and silica to mechanical and thermal energy to at least one of adhere, partially embed, or embed the silica on the coated API particles, wherein the coated API particles comprise 0.5-5% w/w silica;
sieving the coated API particles comprising silica to remove excess coating material not bound to the coated API particles comprising silica;
mixing the coated API particles comprising silica into a matrix solution or suspension to form a pharmaceutical suspension;
dosing the pharmaceutical suspension into a mold;
freezing the pharmaceutical suspension in the mold; and
freeze drying the frozen pharmaceutical suspension to form the pharmaceutical composition.

US Pat. No. 11,026,891

TRANSMEMBRANE PH-GRADIENT POLYMERSOMES AND THEIR USE IN THE SCAVENGING OF AMMONIA AND ITS METHYLATED ANALOGS

Eth Zurich, Zurich (CH)

16. A method treating an ammonia or ammonia methylated analog-associated disease or disorder, or a symptom thereof, comprising a step of administering to a subject in need thereof, a composition comprising a polymersome comprising:(a) a membrane, which comprises a diblock copolymer of poly(styrene) (PS) and poly(ethylene oxide) (PEO), wherein the PS/PEO molecular weight ratio is from 1.3 to 3.8, and
(b) a core which encloses an acid, wherein the composition optionally includes at least one pharmaceutically acceptable excipient.

US Pat. No. 11,026,889

POLYMERIC DRUG DELIVERY SYSTEMS FOR TREATMENT OF DISEASE

Board of Regents, The Uni...

1. A polymer, wherein the polymer is a block copolymer comprising a polyacrylic acid backbone with a first plurality of PEG sidechains and a second plurality of ?-caprolactone sidechains, and wherein the ?-caprolactone sidechains terminates with carboxy, phosphonate, or hydroxysulfonyl.

US Pat. No. 11,026,885

BIOERODIBLE SILICON-BASED DEVICES FOR DELIVERY OF THERAPEUTIC AGENTS

EYEPOINT PHARMACEUTICAS, ...

1. A method of administering a sustained-release therapeutic agent, comprising contacting a bioerodible porous silicon-based carrier material preloaded in a syringe with an aqueous solution comprising the therapeutic agent and administering the carrier material to a patient, wherein the bioerodible porous silicon-based carrier material wherein the carrier material comprises at least one large molecule therapeutic agent disposed in pores of the carrier material, wherein the therapeutic agent is a protein, and either:a) the pores have an average pore size from about 15 nm to about 40 nm and the therapeutic agent has a molecular weight from about 100,000 to about 200,000 amu, or
b) the pores have an average pore size from about 25 nm to about 40 nm and the therapeutic agent has a molecular radius from about 6 nm to about 8 nm.

US Pat. No. 11,026,883

LYOPHILIZED PHARMACEUTICAL COMPOSITIONS FOR VAGINAL DELIVERY

Catalent U.K. Swindon Zyd...

1. A solid lyophilized vaginal dosage form including:a) an effective amount of at least one active ingredient;
b) a crystalline structure forming agent in an amount of 12.5 wt. % to 25 wt. %, based on the total weight of the lyophilized dosage form; and
c) at least one polymeric mucoadhesive matrix forming agent;
wherein the dosage form disintegrates within 120 seconds after being contacted with a vaginal mucosa.

US Pat. No. 11,026,867

BABY BOTTLE

TOMY INTERNATIONAL, INC.,...

1. A container assembly comprising:a container body including an upper end having a first compression surface and a first upwardly extending lip;
a container capable of being received within the container body, the container including a first flange configured to engage the first compression surface and a first downwardly extending lip when the container assembly is in a disassembled state, the first downwardly extending lip being configured to align the container with the container body when a user places the container into the container body;
a collar capable of being releasably secured to the container body, the collar including a second compression surface and a second downwardly extending lip; and
a dispensing portion including a second flange configured to engage the second compression surface and a second upwardly extending lip;
wherein, when securing the collar to the container body, the first compression surface engages the first flange and the second compression surface engages the second flange to cause the first flange to sealingly engage the second flange,
wherein the first upwardly extending lip of the container body has a substantially vertical surface configured to engage a substantially vertical surface of the first downwardly extending lip of the container and the second upwardly extending lip of the dispensing portion has a substantially vertical surface configured to engage a substantially vertical surface of the second downwardly extending lip of the collar when the collar is secured to the container body,
wherein the first upwardly extending lip includes at least a portion of the first compression surface and extends above an upper surface of the container body, and
wherein the substantially vertical surface of the first downwardly extending lip is positioned radially outward with respect to the substantially vertical surface of the first upwardly extending lip and the at least the portion of the first compression surface.

US Pat. No. 11,026,866

BOX WITH TAMPER BAND AND METHOD OF MANUFACTURING THE SAME

Tessy Plastics Corporatio...

1. A method of forming a cap assembly by a two-shot method, the method comprising:injection molding a cap in a first shot from a first polymeric material, wherein the cap has an opening at one end defined by a perimeter; and
injection molding a tamper band in a second shot from a second polymeric material such that the tamper band is monolithically attached to the perimeter of the cap, the step of injection molding the tamper band providing a cap assembly,
wherein the first polymeric material and the second polymeric material comprise dissimilar resins and wherein the tamper band is configured to sever from the cap with no burrs remaining on the perimeter of the cap.

US Pat. No. 11,026,865

ACCELERATED DRYING OF SOFT CAPSULES IN A CONTROLLED ENVIRONMENT

R.P. Scherer Technologies...

1. A method of drying soft capsules comprising steps of:a) supplying an airflow to said soft capsules at a velocity of the air across the soft capsules of from about 0.15 m/s to about 13 m/s;
b) increasing, over time, a drying temperature to which said soft capsules are exposed while ensuring that the drying temperature remains below a melting temperature of a capsule shell of the soft capsules;
c) exposing said soft capsules to an initial relative humidity of from about 49% RH to about 79% RH;
d) decreasing the relative humidity to which the soft capsules are exposed as the capsules dry until an equilibrium relative humidity of the soft capsules reaches a desired relative humidity; and
e) exposing the soft capsules from step d) to a temperature of from 20-25° C.

US Pat. No. 11,026,864

CONNECTOR SECTION

EQUASHIELD MEDICAL LTD., ...

1. A locking element for a connector configured to connect a first component to a second component of a fluid transfer system, the locking element comprising:a. a body comprising an upper part having a hollow interior and a lower part having a channel passing through it;
b. elongated flexible arms having distal enlarged elements attached to the sides of the upper part of the body and projecting downwards parallel to the sides of lower part of the body; and
c. an insert configured to be inserted into the channel, wherein the insert is made of flexible material and comprises at least one bore passing through it which forms a sleeve through which at least one hollow needle is able to pass;
characterized in that the locking element comprises a rigid flat plastic annular disc at the free end of the lower part of the body; the rigid flat plastic annular disc configured to be pressed tightly against a septum that seals against a proximal end of the second component of the fluid transfer system.

US Pat. No. 11,026,863

CONNECTING AND CONTAINER SYSTEM

BOEHRINGER INGELHEIM VETM...

1. A container having a connecting arrangement for providing a fluidic connection between the container and another container, wherein, in an initial state, the connecting arrangement is fluidically sealed in an opening region and can be opened in order to produce the fluidic connection, the opening region being covered by another connecting arrangement, whereinthe container comprises a sealing arrangement which uninterruptedly seals off a volume, the volume covering or bordering to the opening region, by means of the other connecting arrangement during movement of the other connecting arrangement relative to the connecting arrangement,
wherein the connecting arrangement and the other connecting arrangement are configured for mutual opening by breaking frangible points of the opening regions, whereby a continuous fluidic connection is producible by irreversible destruction of the connecting arrangements in the opening region, and
wherein the connecting arrangement and the other connecting arrangement comprise mouth-shaped portions which are formed such that the mouth-shaped portion of one of the connecting arrangement and the other connecting arrangement is able to extend into the mouth-shaped portion of the other of the connecting arrangement and the other connecting arrangement.

US Pat. No. 11,026,862

MEDICATION DELIVERY, DOSING AND SAFETY DEVICES, SYSTEMS AND KITS

ANAL-GESIC LLC, Lexingto...

1. A kit, comprising:a first compartment defining a reservoir, the first compartment including a first lid enclosing the reservoir, the first lid including a first tab that facilitates opening or removing the first lid to access the reservoir, the first compartment removably packaging a single application dosage of a topical medicament such that the topical medicament is positioned inside the reservoir; and
a second compartment defining a cavity, the second compartment including a second lid enclosing the cavity, the second lid including a second tab that facilitates opening or removing the second lid to access the cavity, the second compartment removably packaging a glove having one finger lumen such that the glove is positioned inside the cavity;
wherein the first compartment and the second compartment are rigid;
wherein the first tab and the second tab extend beyond a periphery of the first compartment and the second compartment, respectively;
wherein the first compartment and the second compartment are separately openable;
wherein the second compartment is positioned on top of the first compartment such that the first lid of the first compartment forms a bottom wall of the second compartment that separates and seals the first compartment from the second compartment;
wherein the glove lays on top of and along the first lid;
wherein the first compartment defines an opening through which the topical medicament is removable from the reservoir in response to the first lid being opened;
wherein the first lid continues to form the bottom wall of the second compartment when the first lid is opened; and
wherein the kit is configured for a single use prior to disposal.

US Pat. No. 11,026,861

PHYSICAL THERAPY DEVICE

1. A therapeutic device comprising:a base, a plurality of telescopic stanchions, and a massaging structure;
wherein the massaging structure and the base attach to the plurality of telescopic stanchions;
wherein the plurality of telescopic stanchions elevate the massaging structure above a supporting surface;
wherein the therapeutic device is adapted for use with a patient;
wherein the therapeutic device massages a leg of the patient;
wherein the massaging structure rotates such that the rotation of the massaging structure massages the leg of the patient;
wherein the massaging structure comprises a roller structure and a foam cushion;
wherein the roller structure is a prism-shaped structure;
wherein the roller structure is a rotating structure;
wherein the foam cushion covers a lateral face of the prism-shaped structure of the roller structure;
wherein the roller structure comprises a first rolling element bearing, a second rolling element bearing, and a rotating shaft;
wherein the first rolling element bearing attaches a sixth arm to the rotating shaft such that the rotating shaft rotates relative to a fifth arm of a rotating post;
wherein the second rolling element bearing attaches a second roller post of a third arm to the rotating shaft such that the rotating shaft rotates around an axis of rotation with a center axis of the rotating shaft.

US Pat. No. 11,026,860

METHOD AND DEVICE FOR OPTICAL OPHTHALMIC THERAPY

IRIDEX, Mountain View, C...

1. An optical scanning system for performing therapy on target eye tissue of a patient, comprising:a light source for producing a beam of light;
a scanning device that includes at least one movable optical element for moving the beam of light to produce a pattern of the light beam;
a controller for controlling the scanning device to create the light beam pattern in response to a user command from an input device;
at least one lens for focusing the pattern of the light beam from the scanning device in a telecentric manner; and
an ophthalmic lens assembly having a contact surface for contacting the patient and having a reflective optical element for reflecting the light beam pattern from the at least one lens onto the target eye tissue;
wherein the at least one lens is configured such that the telecentric focusing of the pattern is parallel to an optical axis of the ophthalmic lens assembly before reaching the ophthalmic lens assembly.

US Pat. No. 11,026,859

WEARABLE ROBOTIC UPPER BODY GARMENT

United States of America ...

5. A method for actively controlling an upper extremity of a user, comprising:providing an upper-body apparatus comprising:
a shoulder saddle wherein said shoulder saddle is comprised of a yoke and a first elevated shoulder section;
a back torso section structurally connected to said yoke;
a front torso section structurally connected to said yoke;
a torso wrap structurally connected to said back torso section and capable of structural connection with said front torso section, wherein the torso wrap is comprised of two or more components;
one or more actuators each structurally connected to either said back torso section or front torso section wherein each of said one or more actuators are comprised of one or more motors;
one or more flexible tendons operationally connected to a predetermined one of said one or more actuators, wherein said one or more flexible tendons is comprised of a first flexible tendon, a second flexible tendon, a third flexible tendon, and a fourth flexible tendon;
an upper arm cuff in operational relationship with said one or more flexible tendons;
a lower arm cuff in operational relationship with said one or more flexible tendons;
wherein said first flexible tendon is routed from said one or more motors to said first elevated shoulder section at a first predetermined position on said first elevated shoulder section, wherein said first flexible tendon is connected to said upper arm cuff at a first predetermined termination point,
wherein said second flexible tendon is operationally connected to said one or more motors and routed from said one or more motors to said first elevated shoulder section at a second predetermined position on said first elevated shoulder section, wherein said second flexible tendon is connected to said upper arm cuff at a second predetermined termination point,
wherein said third flexible tendon is routed from said one or more motors to said first elevated shoulder section at a third predetermined position on said first elevated shoulder section, wherein said third flexible tendon is connected to said upper arm cuff at a third predetermined termination point,
wherein said fourth flexible tendon is routed from said one or more motors and is connected to said upper arm cuff at a fourth predetermined termination point, and
wherein said first flexible tendon, said second flexible tendon, said third flexible tendon, and said fourth flexible tendon are configured to effectuate shoulder movement of the user,
wherein said upper arm cuff includes an anterior section, a lateral section, a medial section, and a posterior section,
wherein said first predetermined position is located on an anterior side of said first elevated shoulder section, said second predetermined position is located on a lateral side of said first elevated shoulder section, and said third predetermined position is located on a posterior side of said first elevated shoulder section,
wherein said first predetermined termination point is located on said anterior section of said upper arm cuff,
wherein said second predetermined termination point is located on said lateral section of said upper arm cuff,
wherein said third predetermined termination point is located on said posterior section of said upper arm cuff, and
wherein said fourth predetermined termination point is located on said medial section of said upper arm cuff;
donning said upper body apparatus on said user;
moving said first flexible tendon and said third flexible tendon in combination to move a shoulder of said user of the upper body apparatus in a shoulder flexion movement and a shoulder extension movement; and
moving said second flexible tendon and said fourth flexible tendon in combination to move the shoulder of the user of the upper body apparatus in a shoulder abduction movement and a shoulder adduction movement.

US Pat. No. 11,026,858

STANDING-UP ASSISTANCE APPARATUS, STANDING-UP ASSISTANCE METHOD, AND NON-TRANSITORY COMPUTER-READABLE RECORDING MEDIUM

PANASONIC INTELLECTUAL PR...

1. A standing-up assistance apparatus, comprising:a first sensor that measures a muscle potential of a lower leg of a user;
a second sensor that measures a knee angle of the user;
a processor that determines whether starting to assist the user in a standing-up motion from a seated state is seated possible based on the measured muscle potential and the measured knee angle; and
an assistance mechanism,
wherein the processor outputs an instruction signal if the processor determines that starting to assist the user in the standing-up motion is possible, wherein the first sensor continues to measure the muscle potential of the lower leg of the user and the second sensor continues to measure the knee angle of the user if the processor determines that starting to assist the user in the standing-up motion is not possible, and
wherein the assistance mechanism starts to assist the user in the standing-up motion when the assistance mechanism receives the instruction signal from the processor.

US Pat. No. 11,026,857

SHOULDER HOLD-DOWN AND LOCKING MECHANISM THEREFOR FOR USE WITH A SURGICAL FRAME

WARSAW ORTHOPEDIC, INC., ...

1. A locking mechanism for use with a surgical frame, the locking mechanism comprising:an arm portion including a first shaft portion, a second shaft portion, and a first flange portion, the arm portion including a first end, an opposite second end, a mid-longitudinal axis extending through the first end and the second end, and a channel extending from at least adjacent the first end to at least adjacent the second end along the mid-longitudinal axis, the channel receiving portions of the second shaft portion therein, the first shaft portion including a first exterior surface, the second shaft portion including a second exterior surface, the first shaft portion adjacent the first end of the arm portion including a first aperture on a first side of the channel, the first shaft portion adjacent the first end of the arm portion including a second aperture on a second side of the channel, and the second shaft portion adjacent the first end of the arm portion including a third aperture;
a handle portion having a clevis portion including a first lateral portion and a second lateral portion, the first lateral portion and the second lateral portion of the handle portion being spaced apart from one another, the first lateral portion of the handle portion including a fourth aperture and a first cam surface formed thereon, and the second lateral portion of the handle portion including a fifth aperture and a second cam surface formed thereon, end portions of each of the first shaft portion and the second shaft portion adjacent the first end of the arm portion being received between the first lateral portion and the second lateral portion of the clevis portion;
a bracket portion and a second flange portion, the bracket portion including at least a third lateral portion and a fourth lateral portion, the third lateral portion and the fourth lateral portion of the bracket portion being spaced apart from one another, the second flange portion being positioned between the third lateral portion and the fourth lateral portion of the bracket portion, the third lateral portion of the bracket portion including a sixth aperture, and the fourth lateral portion of the bracket portion including a seventh aperture, the first lateral portion and the second lateral portion of the handle portion being received between the third lateral portion and the fourth lateral portion of the bracket portion; and
one of a rod and a fastener extending through the first aperture, the second aperture, the third aperture, the fourth aperture, the fifth aperture, the sixth aperture, and the seventh aperture to attach the arm portion, the bracket portion, and the handle portion to one another;
wherein the first cam surface and the second cam surface of the handle portion are contactable to at least one surface of the first flange portion, and movement of the handle portion from an unactuated position to an actuated position causes the first cam surface and the second cam surface to translate on the at least one surface, and simultaneously move the first contact surface of the first flange and the second contact surface of the second flange toward one another, and move the second shaft portion at least partially out of the channel in the first shaft portion to expand the first shaft portion and the second shaft portion relative to one another via interaction of the one of the rod and the fastener in the first aperture, the second aperture, the third aperture, the fourth aperture, the fifth aperture, the sixth aperture, and the seventh aperture.

US Pat. No. 11,026,856

SURGICAL UNDERLAY PAD FOR SECURING A PATIENT TO AN OPERATING TABLE IN A TRENDELENBURG POSITION

Bergad, Incorporated, Ki...

1. A surgical underlay pad (100) for securing a torso of a patient (40) to a top surface (30a) of an operating table (30), where the surgical underlay pad is positioned on the top surface and configured to support the torso prior to tilting the operating table beyond a horizontal position, the surgical underlay pad (100) comprising:a substrate (10) having an upper side (10a) and a lower side (10b); and
a gel material forming a gel coat (20) affixed to at least a portion of the lower side of the substrate (10) and to the upper side of the substrate;
wherein the substrate (10) is flexible and at least one of a polyurethane open cell foam, a paper based material, a fabric, and combinations thereof;
wherein the gel coat (20) is a polyurethane gel having a shear strength;
wherein the shear strength of the gel coat is of a sufficient strength to prevent the surgical underlay pad from sliding on the top surface after the operating table is tilted beyond the horizontal position;
wherein the shear strength of the gel coat allows the surgical underlay pad to be repositioned by vertically lifting and repositioning the pad off the top surface of the operating table without affecting the shear strength of the gel coat;
wherein the shear strength of the gel coat (20) applied to the lower side (10b) of the substrate has a first predetermined shear strength, and the sheer strength of the gel coat (20) applied to the upper side (10a) of the substrate has a second predetermined shear strength;
wherein the gel coat on the upper side of the substrate is a predetermined pattern visually indicating a preferred positioning of the patient's body on the surgical underlay pad (100); and
wherein the torso (40) is configured to be positioned on the gel coat (20) on the upper side of the substrate (10).

US Pat. No. 11,026,855

SYSTEM AND METHOD FOR PATIENT POSITIONING IN AN AUTOMATED SURGERY

1. An apparatus for positioning a patient during a surgical procedure comprising:a support adapted to be positioned against a patient's body, the support comprising means for adjusting the height of the support, the support also comprising a drive mechanism with actuator for moving the support along a generally linear path, and at least one bracket for mounting the drive mechanism to the side of an operating table; and
a remote device for actuating the drive mechanism, the remote device configured at least in part as a controller for the support, the controller communicatively coupled to a surgical navigation system, the surgical navigation system configured to cooperate with the controller to position the support with respect to a change demanded to a boundary, the boundary defining tissue of the patient to which an automated surgical instrument should be applied and tissue of the patient to which the surgical instrument should not be applied.

US Pat. No. 11,026,854

PATIENT STABILIZATION, INFECTION BARRIER, PRESSURE ULCER PREVENTION AND EQUIPMENT PROTECTION DEVICE AND METHODS OF USE

1. A patient position device comprising:a main body portion, the main body portion having:
a first layer having a plurality of pressure distribution features,
a second layer disposed beneath the first layer,
a layer of infection barrier material disposed between the first and second layer;
wherein the main body portion is configured as a general planar support having opposed superior and inferior edges, opposed left and right lateral edges and opposed top and bottom surfaces, and
the layer of infection barrier material has opposed superior edge and inferior edges, opposed left and right lateral edges and opposed top and bottom surfaces, and
the layer of infection barrier material extends laterally beyond the left and right lateral edges of the main body portion, with the opposed lateral edges of the infection barrier material free from bonding;
a pair of arm portions, wherein:
at least one arm portion is adapted to extend laterally from the main body portion,
at least one arm portion includes a layer having a plurality of pressure distribution features;
at least one arm portion includes a sleeve, the sleeve having an open end and a closed end; and
at least one strap, the strap including at least one fastener.

US Pat. No. 11,026,853

PATIENT REPOSITIONING SYSTEM

Hillenbrand Management Co...

1. A patient repositioning system comprising:a mattress having a head end and a foot end and an upper surface;
a sheet residing on the upper surface;
a pulling device operatively connected to the sheet and adapted to pull the sheet toward the head end with a patient residing thereon, thereby to reposition the patient;
a housing holding the pulling device, the housing configured to receive at least a portion of the pulled sheet;
a controller operatively connected to the pulling device; and
a UV disinfection module disposed within the housing and operatively connected to the controller,
wherein the controller activates the UV disinfection module to disinfect the sheet within the housing.

US Pat. No. 11,026,852

SUPPORTING STRUCTURE

HEXOWHEEL, Orsay (FR)

1. A supporting structure (100), comprising:a load-receiving part (1), configured for receiving a load to be transported or assisted during moving;
two pairs of legs (2), each leg pair being arranged from one lateral side of the load-receiving part which is opposite another lateral side of said load-receiving part dedicated to the other leg pair, all legs (2) extending from the load-receiving part (1) towards ground when the supporting structure (100) is in a use condition on horizontal ground, and being adapted for maintaining the load-receiving part above the ground; and
four wheels (2w) with respective rotation axes oriented horizontally when the supporting structure (100) is in the use condition on horizontal ground, each leg (2) being provided with one of said wheels at a lower end of said leg which is opposite a connection of said leg to the load-receiving part (1),
wherein each leg (2) comprises an upper segment (2u) and a lower segment (21),
wherein for each leg an upper end of the upper segment is rotationally connected to the load-receiving part (1) with a first rotation axis (A1), and a lower end of the upper segment is rotationally connected to an upper end of the lower segment with a second rotation axis (A2), and a lower end of the lower segment forming the lower leg end opposite the connection of said leg to the load-receiving part, first and second rotation axes of all legs being parallel and horizontal when the supporting structure (100) is in the use condition on horizontal ground,
wherein the supporting structure (100) is adapted to be configured into a reference crossed leg position in the use condition on horizontal ground with the wheels (2w) all located on the ground, in which both legs (2) on each lateral side of the load-receiving part (1) extend downwards while crossing each other in projection into a sagittal plane of the supporting structure,
wherein the supporting structure (100) is further adapted for performing a lowering of the load-receiving part (1) towards the ground from the reference crossed leg position, by bending each leg (2) upwardly about the second axis (A2) of said leg so as to reduce an angle (?) between the upper (2u) and lower (21) segments of said leg at the second axis, simultaneously for all four legs, thus increasing a first distance (d1) between both wheels (2w) on each lateral side of the load-receiving part, while both legs on each lateral side keep crossing each other in projection into the sagittal plane,
said supporting structure (100) configured for forming an exoskeleton for a disabled person in which the load-receiving part (1) is a seat or backrest adapted for supporting at least one among a pelvis or a trunk of the disabled person, the wheels (2w) being freewheels during at least part of use of said supporting structure by the disabled person, and the supporting structure being movable on the ground by feet of the disabled person contacting and pulling the ground while the pelvis or trunk of said disabled person is supported by the load-receiving part (1).

US Pat. No. 11,026,851

ABSORBENT ARTICLE

UNICHARM CORPORATION, Eh...

1. An absorbent article having a longitudinal direction, a lateral direction intersecting the longitudinal direction, and a front-back direction intersecting the longitudinal direction and the lateral direction, the absorbent article comprising:a front waist portion extending along the lateral direction;
a back waist portion extending along the lateral direction; and
a crotch portion provided between the front waist portion and the back waist portion,
wherein
a lateral end portion of the back waist portion on a first side of the absorbent article and a lateral end portion of the front waist portion on the first side are joined by a first joining portion,
the back waist portion has a fastening portion provided on a second side of the absorbent article opposite to the first side in the lateral direction, the fastening portion being configured to be fastened to the front waist portion when putting on the absorbent article,
the front waist portion has a target region, the target region being a region to which the fastening portion is to be fastened,
the crotch portion has a central line that bisects a dimension of the crotch portion in the lateral direction,
a lateral end of the target region on the first side is located, in the lateral direction, between the lateral end portion of the front waist portion and the central line of the crotch portion,
when putting on the absorbent article, a first leg opening is formed on the first side of the absorbent article and a second leg opening is not formed on the second side of the absorbent article, and
the absorbent article is configured such that the second leg opening is formed by fastening the fastening portion to the target region while one of a wearer's legs has been inserted through the first leg opening.

US Pat. No. 11,026,850

NONWOVEN FABRIC FOR OUTER SHEET OF ABSORBENT ARTICLE, AND ABSORBENT ARTICLE INCLUDING THE NONWOVEN FABRIC AS OUTER SHEET

UNICHARM CORPORATION, Eh...

1. A nonwoven fabric for an outer sheet of an absorbent article comprising a liquid-impermeable sheet having moisture vapor permeability, whereinthe nonwoven fabric has a thickness direction and a planar direction, and a first surface and a second surface,
the nonwoven fabric includes thermoplastic resin fibers, and cellulosic fibers of which at least a portion form a plurality of separate fiber masses,
the nonwoven fabric comprises a plurality of gaps that are adjacent to first regions of each of the plurality of separate fiber masses that are facing the first surface,
each of the plurality of separate fiber masses are not joined with the thermoplastic resin fibers,
the nonwoven fabric comprises a matrix including at least the thermoplastic resin fibers, and
the plurality of separate fiber masses are dispersed in the matrix of the thermoplastic resin fibers.

US Pat. No. 11,026,849

MALE INCONTINENCE GUARD AND METHOD FOR MANUFACTURING A MALE INCONTINENCE GUARD

1. A male incontinence guard comprising a fluid-impermeable backsheet, a fluid-permeable topsheet and an absorbent body arranged between said backsheet and said topsheet, wherein said topsheet faces the user when the incontinence guard is worn by said user, said guard having a longitudinal extension along a longitudinal axis (Y1) and a transverse extension along a transverse axis (X1), said transverse axis (X1) dividing said guard into an upper region and a lower region, said upper region having a greater maximum extension along the transverse axis (X1) than the maximum extension of the lower region along said transverse axis (X1), said absorbent body comprising a primary core and a secondary core arranged in a stacked configuration, wherein said primary core has an area in an XY plane which is greater that the area of said secondary core, and the secondary core is formed with side edges being at least partly generally parallel to said longitudinal axis (Y1), wherein the length of each of said generally parallel side edges is within an interval of 10-70% of a maximum extension of the incontinence guard in a longitudinal direction of the incontinence guard.

US Pat. No. 11,026,848

METHOD AND APPARATUS FOR ADVANCING AND FOLDING AN ABSORBENT ARTICLE

1. A method of folding an absorbent article comprising:rotating a drum about a central longitudinal drum axis, wherein the drum comprises a fluid chamber and an outer circumferential drum surface;
rotating a carrier member, at least a portion of the carrier member being disposed adjacent a portion of the outer circumferential drum surface, wherein the carrier member defines a plurality of apertures, wherein the plurality of apertures are configured to be disposed over the fluid chamber of the drum;
positioning a central body portion of the absorbent article on the carrier member;
holding the central body portion of the absorbent article against the carrier member;
advancing the absorbent article on the drum about the central longitudinal drum axis creating a centrifugal force, wherein a first end region of a belt on the absorbent article is deflected in a first direction away from and at an angle ? to the central longitudinal drum axis and a second end region of the belt is deflected in the first direction away from and at an angle ? to the central longitudinal drum axis, wherein the angle ? is from 30 degrees to 135 degrees;
pushing the first end region toward the central body portion of the absorbent article such that the first end region is disposed on the central body portion; and
pushing the second end region of the belt toward the central body portion of the absorbent article such that the second end region is disposed on a portion of the first end region to form a folded absorbent article.

US Pat. No. 11,026,847

SYSTEMS AND METHODS FOR WOUND HEALING

15. A system for improving wound healing, comprising:a wound dressing having a wound-facing surface and a second surface, the wound-facing surface configured to contact a wound of a patient; and
at least one conduit having an interior lumen, the conduit operably connectable to the second surface of the wound dressing, wherein the conduit comprises a window configured to allow air flow from the interior lumen of the conduit to the wound-facing surface of the wound dressing;
wherein the conduit is configured to be positioned beneath a user's nostrils.

US Pat. No. 11,026,846

ELBOW COMPRESSION WRAP AND CORRESPONDING METHODS

Medline Industries, Inc.,...

1. A compression wrap, comprising:an elongated wrap body extending from a first end to a distal end;
a fastening tab coupled to a first major face of the elongated wrap body at the first end;
a fastening loop coupled to the first major face of the elongated wrap body at the distal end;
a compression pad disposed along a second major face of the elongated wrap body between the first end and the distal end, the compression pad defining an ovular perimeter along the second major face of the elongated wrap body; and
a stretchable layer straddling the compression pad with a first stretchable layer end coupled to the second major face of the elongated wrap body to a first side of the compression pad and a second stretchable layer end coupled to the second major face of the elongated wrap body to a second side of the compression pad such that the stretchable layer and a portion of the elongated wrap body comprising the compression pad define a stretchable sleeve, the stretchable layer defining a width that is less than another width of the portion of the elongated wrap body comprising the compression pad.

US Pat. No. 11,026,845

WOUND-CONNECTION PADS FOR FLUID INSTILLATION AND NEGATIVE PRESSURE WOUND THERAPY, AND SYSTEMS AND METHODS

KCI Licensing, Inc., San...

1. A fluid-delivery system for providing fluid to a wound insert adapted to be in fluid communication with a wound, comprising:a wound dressing comprising a drape configured to be disposed over a wound insert;
a fluid-delivery connection pad configured to be fluidly coupled to the wound insert through a first aperture in the drape, comprising:
a first domed cover having a dressing side and a connection side, the dressing side forming a cavity having an upper portion and a base portion adapted to be disposed proximate the wound insert,
a fluid lumen connection on the connection side configured to be coupled to a fluid source and having a fluid-delivery lumen on the dressing side extending from the fluid lumen connection, and
a flange extending radially outward from the first domed cover and defining a terminus of the base portion, wherein the fluid-delivery lumen extends into the cavity for providing fluid to the wound insert; and
a vacuum connection pad configured to be fluidly coupled to the wound insert through a second aperture in the drape, the second aperture being separated a distance from the first aperture.

US Pat. No. 11,026,844

LOW PROFILE FLEXIBLE PRESSURE TRANSMISSION CONDUIT

KCI Licensing, Inc., San...

1. A system for treating a tissue site, comprising:a foam interface adapted to be positioned in fluid communication with the tissue site;
a dressing adapted to cover the foam interface at the tissue site, the dressing comprising:
a first sealing member adapted to provide a sealed space between the first sealing member and the tissue site,
a first wicking layer disposed in the sealed space,
a second wicking layer disposed in the sealed space, and
an absorbent layer disposed between the first wicking layer and the second wicking layer;
wherein a peripheral portion of the first wicking layer is directly coupled to a peripheral portion of the second wicking layer providing a wicking layer enclosure surrounding the absorbent layer between the first and the second wicking layer;
a low-profile conduit adapted to be fluidly coupled to the dressing and comprising a receiving end and a transmitting end separated by a length, the transmitting end configured to be coupled to the dressing, the low-profile conduit further comprising a receiving end aperture at the receiving end, a transmitting end aperture at the transmitting end, a manifold, and a second sealing member, the manifold sealingly enclosed and encapsulated within the second sealing member;
a conduit interface adapted to be coupled to the receiving end of the low-profile conduit, the conduit interface in fluid communication with the dressing through the low-profile conduit;
a reduced pressure source; and
a conduit adapted to be fluidly coupled between the conduit interface and the reduced pressure source, wherein a distal end of the conduit includes a coupling configured to attach to the reduced pressure source.

US Pat. No. 11,026,843

ACOUSTIC ATTENUATING EAR MUFFS WITH MECHANICALLY ACTUATED ATTENUATION PLUGS

INTERNATIONAL BUSINESS MA...

1. Acoustic attenuating ear muffs comprising:a first ear pod including a first ear cup having an inner surface and an outer surface and a first acoustic attenuating member including a first opening coupled to the first ear cup;
a second ear pod including a second ear cup having an inner surface portion and an outer surface portion and a second acoustic attenuating member including a second opening coupled to the second ear cup;
a connecting member linking the first ear pod to the second ear pod;
a first selectively deployable plug member arranged between the inner surface and the first acoustic attenuating member; and
a second selectively deployable plug member arranged between the inner surface portion and the second acoustic attenuating member.

US Pat. No. 11,026,842

METHOD OF PROVIDING AGENTS TO THE COCHLEA

NewSouth Innovations Pty ...

1. A cochlear implant, comprising:auditory nerve stimulator circuitry to generate an auditory nerve stimulator electrical pulse profile;
a linear array of electrodes configured as a series of independently addressable nodes along a length of the cochlear implant which lies within the cochlea, each of the series of independently addressable nodes coupled to the auditory nerve stimulator circuitry for providing the auditory nerve stimulator electrical pulse profile to the cochlea; and
electroporation-driving circuitry, separate from the auditory nerve stimulator circuitry, coupled to a plurality of the independently addressable nodes of the linear array of electrodes of the cochlear implant for electroporation using one or more electrodes as anodes and one or more other electrodes interspersed along the linear electrode array as cathodes for electroporation current delivery such that the cochlear implant can generate an electroporation mode electrical pulse profile delivering high field strength current, and
provide the electroporation electrical pulse profiles to the cochlea via the plurality of addressable nodes to transfect cells along the length of the linear array.

US Pat. No. 11,026,841

CLOSED-LOOP LASER EYE SURGERY TREATMENT

AMO Development, LLC, Sa...

1. A laser eye surgery system, comprising:a laser system to generate a laser beam and direct the laser beam to an eye of a patient;
a topography measurement system for measuring topography of a cornea of the eye;
a processor coupled to the laser system and the topography measurement system, the processor comprising a tangible non-volatile computer recordable medium embodying instructions to:
measure a first corneal topography of the eye using the topography measurement system;
determine a first curvature of the cornea based on the first corneal topography, and determine a target curvature of the cornea that provides a desired treatment of the eye;
determine a first set of incisions in the cornea to achieve the target curvature of the corneal;
determine a first set of first partial incisions in the cornea, wherein the first partial incisions are smaller than the incisions of the first set of incisions;
perform the first set of first partial incisions on the cornea using the laser system;
measure a second corneal topography using the topography measurement system after performing the first set of first partial incisions;
determine a second curvature of the cornea based on the second corneal topography;
determine whether the second curvature differs from the target curvature by more than a predetermined threshold;
when it is determined that the second curvature and the target curvature do not differ by more than the predetermined threshold, then end treatment of the eye; and
when it is determined that the second curvature and the target curvature differ by more than the predetermined threshold, then:
determine a second set of incisions in the cornea different from the first set of incisions to achieve the target curvature in the cornea; and
determine a second set of second partial incisions in the cornea; wherein the second partial incisions of the second set of partial incisions are smaller than the incisions of the second set of incisions; and
perform the second set of second partial incisions on the cornea using the laser system.

US Pat. No. 11,026,840

OPHTHALMIC SURGERY METHOD

CARL ZEISS MEDITEC AG, J...

1. A treatment apparatus for eye surgery, comprising:a laser device which produces at least one cut surface in the cornea by use of laser radiation in accordance with control data, and
a planning device for producing the control data, wherein the planning device comprises a computer configured to determine the at least one corneal cut surface on the basis of data of a laser induced refractive index change (LIRIC) structure, and, for the at least one corneal cut surface, produce a control data record for use in treating an eye of a Patient by actuating the laser device to produce the at least one corneal cut surface by making laser cuts on the eye based on the control data, and
wherein the computer is configured to determine the treatment of at least one corneal cut surface in such a way that the LIRIC structure is enclosed by the at least one cut surface, and the planning device is further configured to receive the data of the LIRIC structure and to transmit control data of the control data record to the laser device to enable the laser device to treat the eye by producing the at least one corneal cut surface that encloses the LIRIC structure when actuated.

US Pat. No. 11,026,839

TREATMENT TO IMPROVE ADHESIVE PROPERTIES OF CORNEAL IMPLANT

EyeYon Medical Ltd., Nes...

1. A method for preparing an implant for attachment to a posterior surface of the cornea, comprising:providing a corneal copolymer implant comprising the monomer 2-hydroxyethyl methacrylate and having an anterior surface and a posterior surface, and
exposing at least the anterior surface of the implant to a treatment that improves adhesion between the implant and the cornea.

US Pat. No. 11,026,838

PHOTODISRUPTIVE LASER FRAGMENTATION OF TISSUE

Alcon Inc.

1. An ophthalmic laser surgical system, comprising:a pulsed laser source configured to generate a pulsed laser beam;
an imaging device configured to capture image data and measure structural properties of a lens of an eye;
an optics module with optics configured to direct the laser beam towards a plurality of target regions in the lens of the eye, wherein the laser beam is applied as a plurality of spots at the target regions, wherein the plurality of spots are generated in a laser pattern with a spot separation selected based on the structural properties of the lens, wherein at least a portion of the target regions include a bulk portion of the lens having concentric layers of elongated fibers; and
a system control module configured to control, based on the image data and the structural properties of the lens, the optics module to form an array of cells in the target region by creating a plurality of layers of photodisrupted bubbles and a plurality of walls of photodisrupted bubbles to generate cell boundaries, wherein the system control module is further configured to control the optics module to direct pulsed laser source to generate the laser pattern with a spot separation with a higher spot density and/ or a higher laser pulse energy to form cell boundaries that are perpendicular to the elongated fibers, as compared to when the cell boundaries are located parallel to elongated fibers.

US Pat. No. 11,026,837

SYSTEMS AND METHODS FOR OCULAR LASER SURGERY AND THERAPEUTIC TREATMENTS

ACE VISION GROUP, INC., ...

1. A system for delivering microporation medical treatments to improve biomechanics, the system comprising:a laser for generating a beam of laser radiation on a treatment-axis not aligned with a patient's visual-axis, operable for use in subsurface ablative medical treatments to create an array pattern of micropores that improves biomechanics;
a housing;
a controller within the housing, in communication with the laser and operable to control dosimetry of the beam of laser radiation in application to a target tissue;
a lens operable to focus the beam of laser radiation onto a target tissue;
an automated off-axis subsurface anatomy tracking, measuring, and avoidance system; and
wherein the array pattern of micropores is at least one of a radial pattern, a spiral pattern, a phyllotactic pattern, or an asymmetric pattern, and wherein the array pattern of micropores has a controlled asymmetry which is an at least partial rotational asymmetry about the center of the array pattern and extends to at least 51 percent of the micropores of the array pattern.

US Pat. No. 11,026,836

OCULAR IMPLANTS FOR DELIVERY INTO AN ANTERIOR CHAMBER OF THE EYE

IVANTIS, INC., Irvine, C...

1. A method of treating glaucoma in a human eye, the method comprising:inserting a cannula through a cornea of the eye into an anterior chamber of the eye;
placing a distal opening of the cannula in communication with Schlemm's canal of the eye;
moving an ocular implant out of the cannula through the opening and into Schlemm's canal, the ocular implant comprising a central channel, a central channel opening and first and second landing surfaces on first and second sides of the implant, respectively, the first and second sides being unequal in height, the first and second landing surfaces being disposed on opposite sides of the central channel and the central channel opening, the central channel and the first and second landing surfaces extending longitudinally along Schlemm's canal; and
engaging a scleral wall of Schlemm's canal with the first and second landing surfaces such that reaction forces on the first and second landing surfaces from engagement with the scleral wall as the ocular implant is moving out of the cannula and into Schlemm's canal are substantially equal.

US Pat. No. 11,026,835

SYSTEMS, DEVICES AND METHODS INCLUDING GALVANIC AND CALORIC VESTIBULAR STIMULATION

Scion NeuroStim, LLC, Ra...

1. A method of vestibular neurostimulation, comprising:delivering a modulated electrical signal to a patient through galvanic vestibular stimulation (GVS); and
delivering a time varying thermal waveform to the patient through caloric vestibular stimulation (CVS) simultaneous with the delivery of the modulated electrical signal through GVS,
wherein the modulated electrical signal delivered through GVS and/or the time varying thermal waveform delivered through CVS is configured to increase a passage of insulin-like growth factor 1 (IGF-1) through a blood-brain-barrier.

US Pat. No. 11,026,834

BODY TEMPERATURE CONTROLLING SYSTEM

Cesaroni Aerospace Incorp...

1. A wearable body temperature controlling system comprising:a manifold comprising a feed blower, a return blower, and at least one regenerative heat exchanger, the feed blower drawing an incoming flow of gas, the at least one regenerative heat exchanger cooling the incoming flow of gas; and
at least one conduit receiving the incoming flow of gas from the manifold and directing the incoming flow of gas onto a wearer thereof,
wherein the return blower draws a return flow of gas from the wearer, and wherein the at least one regenerative heat exchanger receives the return flow of gas to cool the incoming flow of gas.

US Pat. No. 11,026,833

TEMPERATURE CONTROL DEVICE FOR FLUID-BASED HYPER/HYPOTHERMIA SYSTEMS

1. A method of running a perfusion hyper/hypothermia system including a temperature control device and a connection unit, wherein the temperature control device includes a fluid temperature control unit including a plurality of electrical consuming components, a supply pump to pump fluid, and a power supply unit, wherein the method of running the perfusion hyper/hypothermia system comprises:receiving an alternating current power input from a local power network through the connection unit;
performing power conversions, using the power supply unit, from the alternating current power input to a plurality of direct current power outputs, such that each of the plurality of direct current power outputs is one of a constant mode output and a variable mode output and the plurality of direct current power outputs includes a first direct current power output that is a first variable mode output and a second direct current power output that is a second variable mode output;
supplying the plurality of direct current power outputs to the supply pump and the plurality of electrical consuming components including a heater, a cooler, a temperature sensor, and a temperature controller, including supplying the first direct current power output with the first variable mode output to the supply pump and the second direct current power output with the second variable mode output to at least one of the heater and the cooler;
controlling the plurality of direct current power outputs to regulate a fluid temperature and a pumping rate; and
circulating the fluid from a fluid container through a pipeline to outside of the temperature control device in the perfusion hyper/hypothermia system and back to the fluid container using the supply pump.

US Pat. No. 11,026,832

INTRAUTERINE DEVICE WITH A RESTRICTED UPWARD MOVEMENT OF A STRING

Pregna International Limi...

1. An intrauterine device with a restricted upward movement of a plurality of strings, having an elongated central vertical stem of an order of 29 to 35 mm in length with a plurality of arms attached on a proximal end of the central vertical stem and a spherical bulge attached on a distal end of the central vertical stem, wherein the plurality of strings are terminated together on one end at the spherical bulge, and each of the plurality of strings has an opposite, unterminated end that together form a hanging portion of said plurality of strings configured to suspend freely from the spherical bulge in the vaginal cavity, and an envelope directly connected to the spherical bulge by at least covering the spherical bulge and wherein the envelope has sealed ends to prevent harboring of infection, and wherein the envelope is disposed around the hanging portion of the plurality of strings emerging from below the spherical bulge to achieve an enhanced stiffness fora projected length of the hanging portion of plurality of strings proximal to the attachment to the spherical bulge, with the hanging portion of plurality of strings extending away from the spherical bulge and beyond said envelope without retention between the envelope and the unterminated ends of the hanging portion of strings, and configured to remain inside the endocervical canal so as to restrict the upward movement of the plurality of strings in the uterus.

US Pat. No. 11,026,831

DENTAL APPLIANCE FEATURES FOR SPEECH ENHANCEMENT

Align Technology, Inc., ...

1. An orthodontic device to manage speech articulation of a patient, the orthodontic device comprising:an occlusal portion having a dentition-receiving cavity configured to receive the patient's teeth and to exert repositioning forces on the patient's teeth, the occlusal portion having an incisor region configured to receive the patient's incisors, wherein the occlusal portion has a first vertical height; and
a barrier portion extending laterally and adjacent to the occlusal portion, wherein the barrier portion is positioned lingual to the incisor region of the occlusal portion while the orthodontic device is worn by the patient, wherein the barrier portion has a second vertical height that is greater than the first vertical height, wherein the barrier portion comprises a sealing surface that is laterally continuous at least along a lateral length of the incisor region to reduce or prevent air leakage and form a seal against the patient's tongue, wherein the sealing surface is configured to preventing lisping while the patient is speaking and wearing the orthodontic device in the patient's mouth; and
wherein a lingual side of the incisor region is physically separated from the barrier portion by a space to reduce pushing forces applied to the patient's incisors from the patient's tongue.

US Pat. No. 11,026,830

TONGUE ADVANCER SYSTEM FOR USE IN A TONGUE MANIPULATION SYSTEM

KONINKLIJKE PHILIPS N.V.,...

1. An implantable tongue advancer system for use in a tongue manipulation device, comprising:a tissue anchor comprising a set of retractable fingers having a retracted configuration in which the tissue anchor is adapted to be loaded into a delivery tube and a deployed configuration in which the fingers are adapted for extending into tongue tissue in forward and lateral directions; and
a spacer which extends from a first end positioned against a head of the tissue anchor to a second end beyond the maximum forward extent of the retractable fingers.

US Pat. No. 11,026,829

HYDRO-BLOCK AIR VENT COMBINATION CATHETER SYSTEM AND METHOD OF USE

1. A hydro-block air vent combination catheter system comprised of:an external catheter selected from the group consisting of: a condom catheter or a catheter capable of covering the female genitalia and containing urine therein;
an external catheter attachment means attached to the external catheter;
an indwelling catheter attachment means attached to the external catheter such that the hydro-block air vent combination catheter system can be used by a user with either the external catheter alone or in combination with an indwelling catheter attached to the external catheter;
a liquid sensor;
a liquid hose;
a pressure relief balloon capable of regulating liquids in the liquid hose such that the liquid sensor will detect the presence of liquids without air bubble interference;
a liquid blocking air vent attached to the external catheter wherein the liquid blocking air vent permits ambient air to enter into or escape from the external catheter and prevents liquid from escaping from within the external catheter; and
a collection means attached to the external catheter wherein the collection means facilitates the passage of urine from the external catheter to a user selected disposal means;
the collection means is comprised of a pump and sensor connector wherein the pump and sensor connector is capable of being connected to a user selected pump, wherein the collection means is attached to the external catheter by the external catheter attachment means thereby permitting a user's urine to: pass out of the external catheter; be detected by the liquid sensor thereby electronically transmitting data regarding the presence of the user's urine to the pump and sensor connector through the sensor hose thereby facilitating the activation of the user selected pump which when attached and activated draws urine away from the external catheter exiting the external catheter into the liquid hose, then through the pump and sensor connector and then through the user selected pump to a user selected disposal means.

US Pat. No. 11,026,828

CLUBFOOT ORTHOTIC

University of Iowa Resear...

1. A kit for treating clubfoot in a patient, the kit comprising:a first platform;
the first platform defines a first slot having a longitudinally aligned central axis extending therethrough,
a second slot having a longitudinally aligned central axis extending therethrough, and
a first locking hole;
a second platform; and
the second platform defines a third slot having a longitudinally aligned central axis extending therethrough,
a fourth slot having a longitudinally aligned central axis extending therethrough, and
a second locking hole;
wherein the longitudinally aligned central axis of the first slot is perpendicular to the longitudinally aligned central axis of the second slot;
a bar having a first end and a second end;
the bar comprises a flexible first cantilever having a first button proximate a first end and a flexible second cantilever having a second button proximate a second end,
the first button sized and shaped to mate with the first locking hole when the first slot mates with the first end, and
the second button sized and shaped to mate with the second locking hole when the second slot mates with the second end.

US Pat. No. 11,026,827

ANKLE FOOT ORTHOSIS (AFO) AND METHOD OF MAKING THE SAME

Bracemasters Internationa...

1. An ankle foot orthosis, comprising:a brace body comprising a first polyolefin elastomeric material, the brace body comprising:
a back portion;
a medial side portion having a medial front edge;
a lateral side portion having a lateral front edge;
a sole portion;
a proximal edge;
a first reinforcement strip of a second polyolefin elastomeric material, the first reinforcement strip being a single medial stirrup-type strip having a first end situated on the medial side portion below the proximal edge and extending as a continuous strip along the medial side portion, under the sole portion and along the lateral side portion, to a second end situated on the lateral side portion below the proximal edge, to hinder talus range of motion and guard against unwanted tri-planar ankle foot motion;
the medial front edge and the lateral front edge being configured for an overlapping arrangement; and
a closure mechanism to tighten the ankle foot orthosis on a foot;
wherein the brace body comprises a closed cell foam inner lining bonded to an outer layer comprising the first polyolefin elastomeric material, with the first reinforcement strip situated between the inner lining and the outer layer;
wherein the first polyolefin elastomeric material is an ethylene-butene copolymer or an ethylene-octene copolymer, and the second polyolefin elastomeric material is selected from the group consisting of polypropylene, polyethylene, and modified polyethylene (MPE); and
wherein the first polyolefin elastomeric material has a melt index of less than 0.5 30 g/10 minutes (measured according to ASTM D 1238), a density of 0.857 to 0.910 g/cc (measured according to ASTM D 792), a melting range of 36° C. to 140° C., a Shore A hardness of 56 to 96 (measured according to ASTM D 2240), and a flexural modulus of from 3 to 110 MPa (measured according to ASTM D 790).

US Pat. No. 11,026,826

FLANGED GASTROINTESTINAL DEVICES AND METHODS OF USE THEREOF

GI Dynamics, Inc., Bosto...

1. A gastrointestinal device comprising:(a) a sleeve configured to carry fluid from its proximal end to its distal end, wherein its proximal end is configured to be at or proximal to a subject's pyloric orifice and its distal end is configured to be at or distal to the subject's duodenum;
(b) an anchor connected to the sleeve, the anchor configured to be retained within a duodenal bulb; and
(c) a flange positioned proximal to the anchor, the flange configured to resist distal migration of the gastrointestinal device,
wherein a coupling liner connects the anchor to the sleeve at a sleeve-coupling interface, wherein a relaxed diameter of the anchor is greater than a maximum diameter of the sleeve at the sleeve-coupling interface; or
wherein the anchor is configured to exert an outward radial force on the sleeve at the sleeve-coupling interface, wherein the outward radial force on the sleeve at the sleeve-coupling interface is configured to maintain the sleeve in an open configuration at the sleeve-coupling interface, wherein the sleeve-coupling interface is at or distal to the distal-most end of the anchor or wherein the sleeve-coupling interface is from 1-6 inches distal to the flange.

US Pat. No. 11,026,825

METHODS, DEVICES, AND SYSTEMS FOR OBESITY TREATMENT

Fulfillium, Inc., Napa, ...

21. A system for obesity treatment, comprising:an obesity treatment apparatus comprising
at least two expandable balloons, wherein each balloon of the at least two expandable balloons comprises a means for receiving and retaining one or more gasses, and
a means for conforming the obesity treatment apparatus, in an inflated state, to a natural three-dimensional kidney shape of the stomach, wherein
the obesity treatment apparatus is configured for delivery via an esophagus of a patient in an uninflated state, and
upon inflation, each balloon of the at least two expandable balloons is configured to occupy a respective volume in a stomach of the patient; and
an inflation apparatus comprising
an inflation catheter releasably securable to the means for receiving and retaining the one or more gasses of each balloon of the at least two expandable balloons for inflating the respective balloon in the stomach of the patient, and
an external pressurized fluid source for coupling to the inflation catheter, wherein
one or more gasses of the external pressurized fluid source are selected to provide buoyancy to the obesity treatment apparatus within the stomach, and
each balloon of the at least two expandable balloons is filled with a same one or more gasses;
wherein, after inflating each expandable balloon with the one or more gasses through the inflation catheter using the pressurized fluid source and releasing the inflation catheter from the respective balloon,
the obesity treatment apparatus is configured to float freely within the stomach of the patient without exerting pressure at any point in the stomach sufficient to cause ulceration.

US Pat. No. 11,026,824

WEARABLE APPARATUS FOR THE TREATMENT OR PREVENTION OF OSTEOPENIA AND OSTEOPOROSIS, STIMULATING BONE GROWTH, PRESERVING OR IMPROVING BONE MINERAL DENSITY, AND INHIBITING ADIPOGENESIS

TheraNova, LLC, San Fran...

1. A wearable apparatus for treating or preventing osteoporosis, comprising:one or more vibrating elements configured for imparting repeated mechanical loads to the hip, femur, and/or spine of an individual at a frequency and acceleration sufficient to induce strain in bone tissue for therapeutic effect on osteoporosis;
one or more securing mechanisms for securing said one or more vibrating elements to the body of said individual such that the one or more vibrating elements are maintained against the body while maintaining portability, wherein said securing mechanisms are configured to position the one or more vibrating elements such that the mechanical loads are applied laterally to the individual; and
an embedded electronics assembly which is configured to track and/or report compliance of apparatus use with a prescribed or recommended usage in accordance with treating or preventing osteoporosis.

US Pat. No. 11,026,823

METHOD AND APPARATUS FOR CONTROLLING THE DEPLOYMENT OF A STENT

Vascutek Limited, Renfre...

1. A delivery apparatus, the apparatus comprising:a delivery shaft with a tubular prosthesis mounted on a proximal end thereof for insertion into a lumen and a distal end remote from the proximal end, the tubular prosthesis comprising a sleeve and at least one discrete axially-extending ring stent that includes a plurality of peaks defining a first axial end thereof and a plurality of valleys defining a second axial end thereof opposite the first axial end, the plurality of peaks and the plurality of valleys being alternatingly arranged and comprising portions thereof that change axial directions, wherein the at least one discrete axially-extending ring stent is attached to the sleeve and configured to maintain patency of the sleeve after deployment of the tubular prosthesis;
a retractable sleeve adapted to contain the tubular prosthesis mounted on the delivery shaft;
a control handle proximate to the distal end of the delivery shaft;
at least one stent peak control wire extending from the control handle and physically coupled to at least one peak of the plurality of peaks at an at least one peak connection point located directly at the at least one peak;
at least one peak controller at the control handle adapted to control the position of the at least one stent peak control wire to selectively open the at least one peak from a collapsed state and collapse the at least one peak from an open state;
at least one stent valley control wire extending from the control handle and physically coupled to at least one valley of the plurality of valleys at an at least one valley connection point located directly at the at least one valley; and
at least one valley controller at the control handle adapted to control the position of the at least one stent valley control wire to selectively open the at least one valley from a collapsed state and collapse the at least one valley from an open state.

US Pat. No. 11,026,822

STENT DELIVERY SYSTEM

C. R. Bard, Inc., Frankl...

1. A stent delivery system, comprising:an inner member having a distal end sized and shaped to receive a stent;
a longitudinally slidable outer member disposed over the inner member and the stent;
a handle connected to the outer member, the handle including a retraction mechanism designed to retract the outer member into the handle; and
a stability sheath disposed over the outer member, wherein the stability sheath is rotatable relative to the inner member and the outer member, the stability sheath comprising:
a proximal end coupled to the handle at an internal section of the handle; and
a disk coupled to the proximal end, wherein the disk is disposed in a circular cavity in the handle to permit free rotation of the stability sheath while preventing axial movement of the stability sheath.

US Pat. No. 11,026,821

DEVICE FOR CATHETER SHEATH RETRACTION

C. R. Bard, Inc., Frankl...

1. A stent delivery device having a locked position and a use position, comprising:a sheath covering a compressed stent;
a housing including a mover reel, the mover reel designed to rotate in the housing, the mover reel coupled to a mover reel actuator, wherein actuation of the mover reel actuator rotates the mover reel in a winding direction;
a sheath pull wire having a proximal end coupled to the mover reel and a distal end coupled to the sheath, wherein rotation of the mover reel in the winding direction winds the sheath pull wire on the mover reel and moves the sheath in a proximal direction; and
a pre-mover separate from the mover reel actuator, the pre-mover comprising:
an arm having a proximal end engaged with the mover reel to prevent rotation in the locked position; and
a pre-mover actuator coupled to the arm and having a portion projecting outside of the housing, wherein movement of the pre-mover actuator disengages the arm from the mover reel and transitions the stent delivery device from the locked position to the use position, wherein disengagement of the arm from the mover reel rotates the mover reel a predetermined amount in the winding direction.

US Pat. No. 11,026,820

STENT DELIVERY DEVICE

BOSTON SCIENTIFIC SCIMED,...

1. A stent delivery device comprising:a handle having a grip, a guide, and a cavity, the guide extending along an inner surface of the cavity; and
a sliding body comprising a body portion defining a longitudinal axis, the sliding body having a plurality of flange portions spaced apart longitudinally and fixed to the body portion, wherein the sliding body is slidable on the guide along the longitudinal axis to a position in which at least a portion of the sliding body including at least one flange portion is disposed within the cavity of the handle.

US Pat. No. 11,026,819

VASCULAR STENT, CONVEYING BALLOON THEREOF, AND IMPLANTING SYSTEM

Evans Scientific (Beijing...

1. An implanting system for implanting a vascular stent, comprising a vascular stent, a stent conveying device for releasably receiving the vascular stent, a light source for illuminating the vascular stent, and a liquid supply pipe for conveying a liquid photocuring supporting material, wherein the vascular stent comprises a flexible light-transmitting body, the flexible light-transmitting body being provided with a hardenable channel, the hardenable channel being arranged in a circumferential direction and an axial direction of the flexible light-transmitting body, wherein the hardenable channel is filled with a liquid photocuring supporting material, and the liquid photocuring supporting material is cured after being illuminated so as to radially support the flexible light-transmitting body; and the liquid supply pipe is detachably connected to the vascular stent,wherein the stent conveying device is a conveying balloon, the conveying balloon comprises a balloon body and a control pipeline for filling the balloon body with air or liquid, the light source is disposed in the balloon body, and a side wall of the balloon body is made of a light-transmitting material,
the implanting system further comprising a pipe cutting assembly, the pipe cutting assembly comprising a top core and a cutting wire, a distal end surface of the top core being formed with a cutting groove, two ends of the cutting wire movably penetrating through the top core along the axial direction from the cutting groove and stretching out from a proximal end, and the liquid supply pipe passing between the cutting wire and the cutting groove.

US Pat. No. 11,026,818

STENT WITH SELECTIVELY COVERED REGION

BOSTON SCIENTIFIC SCIMED,...

1. A stent comprising:a radially expandable tubular framework having a proximal end, a distal end, and a lumen extending therethrough; and
a covering surrounding the tubular framework, the covering being affixed to the tubular framework at a first affixment location;
the covering including a proximal region extending proximal of the first affixment location and surrounding a medial region of the tubular framework;
the covering including a skirt extending distal of the first affixment location and surrounding a distal end region of the tubular framework;
wherein the skirt is selectively removable from the distal end region of the tubular framework to expose the distal end region of the tubular framework; and
a drawstring attached to the skirt, wherein the drawstring extends along the tubular framework to the proximal end of the tubular framework, wherein manipulation of the drawstring removes the skirt from the distal end region of the tubular framework;
wherein the drawstring extends along the tubular framework between an inner surface of the proximal region of the covering and an outer surface of the tubular framework.

US Pat. No. 11,026,817

DEVICE FOR AORTIC REPAIR AND METHOD OF USING THE SAME

Aortic Innovations, LLC, ...

1. A transcatheter heart valve assembly comprising:an inner frame comprising a first graft covering about a prosthetic heart valve, wherein the first graft covering extends proximal the prosthetic heart valve for providing sealing to the prosthetic heart valve;
an outer frame formed from a metallic material and defining an open cell configuration, and being secured to the first graft covering by a plurality of stitches, the outer frame being positioned at least partially radially outwardly of the inner frame; and
a sealing material positioned externally to the outer frame and configured for providing sealing between the outer frame and a patient's anatomical wall to prevent paravalvular leaks,
wherein the sealing material includes a plurality of radially extending fibers, wherein at least some of the radially extending fibers are fibers that extend outwardly of the outer frame;
wherein the first graft covering is made of a polymer,
wherein at least some other of the radially extending fibers engage the first graft covering at a proximal end of the heart valve assembly to seal an inflow end portion thereof,
wherein a second graft covering extends about a distal end of the heart valve assembly to seal an outflow end portion thereof.

US Pat. No. 11,026,816

PROSTHETIC DEVICE

DEKA Products Limited Par...

1. A prosthetic device comprising:a flexure cut extending from a surface of the prosthetic device towards an inner part of the prosthetic device;
a sensor located in a distal portion of the prosthetic device to detect movement in accordance with a degree of movement wherein the sensor is disposed within the flexure cut; and
at least one wire configured to connect the sensor to a proximal portion of the prosthetic device, wherein the at least one wire annularly traversing a joint of the prosthetic device.

US Pat. No. 11,026,815

CONTROLLING POWER IN A PROSTHESIS OR ORTHOSIS BASED ON PREDICTED WALKING SPEED OR SURROGATE FOR SAME

OTTO BOCK HEALTHCARE LP, ...

16. A method, comprising:receiving a sensor output associated with an ankle-foot prosthesis or orthosis, the sensor output serving as a surrogate for a walking speed of a user of the prosthesis or orthosis;
determining, based on the sensor output, a control value corresponding to at least one of: (i) an angular rate w of a shank member at a start of controlled dorsiflexion, the shank member operatively connected to a foot member of the prosthesis or orthosis so as to support walking and permit the foot member to plantarflex and dorsiflex with respect to the shank member, (ii) an angular rate of a leg section above a knee of a user of the prosthesis or orthosis, (iii) a knee linear moving velocity in a stance phase, or (iv) a Cartesian trajectory of an ankle joint of the prosthesis or orthosis or the knee; and
transmit a torque control signal to a motor of the prosthesis or orthosis, the torque control signal being calculated based on the determined control value and configured to control the motor's torque so that the motor's torque for slow walking speeds is lower than the motor's torque for fast walking speeds.

US Pat. No. 11,026,814

PIVOT-FLEX FOOT

University of Washington,...

1. A prosthetic device, comprising:an ankle component;
a foot component coupled to the ankle component, wherein the foot component has a longitudinal length configured to extend at least partially along a sagittal plane of a user when the prosthetic device is in use, wherein the foot component has a thickness configured to extend at least partially along a transverse plane of the user when the prosthetic device is in use, and wherein the foot component comprises a lower cantilever leaf spring; and
a coupling mechanism positioned between the foot component and the ankle component, wherein the coupling mechanism couples a rotation of the foot component with respect to the sagittal plane to a rotation of the foot component with respect to the transverse plane, wherein the coupling mechanism comprises one or more upper cantilever leaf springs each having a transverse cross-section defined by a width configured to extend at least partially along a coronal plane of the user when the prosthetic device is in use and a thickness configured to extend at least partially along the transverse plane of the user when the prosthetic device is in use, and wherein the transverse cross-section of the one or more upper cantilever leaf springs are each configured to be misaligned with the sagittal plane by a rotation angle when the prosthetic device is in use such that if the foot component is subjected to a bending moment along the sagittal plane, the sagittal plane bending moment will simultaneously deflect the foot component along both the sagittal plane and the transverse plane.

US Pat. No. 11,026,813

SPINAL IMPLANT SYSTEM AND METHOD

Warsaw Orthopedic, Inc., ...

1. A surgical system comprising:an interbody implant comprising a substrate, a first endplate and a second endplate, the substrate comprising opposite top and bottom surfaces, the first endplate including a first surface configured to engage the top surface and an opposite second surface, the second endplate including a first surface configured to engage the bottom surface and an opposite second surface, the second surfaces each including teeth; and
a surgical tool including a first jaw and a second jaw, the first jaw comprising a first slot configured for disposal of a perimeter of the first endplate, the second jaw comprising a second slot configured for disposal of a perimeter of the second endplate, the first slot comprising grooves matching a configuration of the teeth of the second surface of the first endplate, the second slot comprising grooves matching a configuration of the teeth of the second surface of the second endplate.

US Pat. No. 11,026,812

INTERVERTEBRAL IMPLANT DEVICE WITH LORDOTIC EXPANSION

Spinal Elements, Inc., C...

1. An expandable interbody fusion implant device comprising:a frame having a first lateral side, a second lateral side, a distal end, and a proximal end;
a distal ramp assembly and a proximal ramp assembly, each having a translating ramp with a threaded opening and at least one pivoting hinged ramp;
a first overlying base plate disposed between the distal end and the proximal end of the frame and hinged to the first lateral side of the frame, the first overlying base plate being hinged to the distal ramp assembly at a first of the at least one pivoting hinged ramp, the first overlying base plate being hinged to the proximal ramp assembly at a second of the at least one pivoting hinged ramp;
a second overlying base plate disposed between the distal end and the proximal end of the frame and hinged to the first lateral side of the frame, the second overlying base plate being hinged to the distal ramp assembly at a third of the at least one pivoting hinged ramp, the second overlying base plate being hinged to the proximal ramp assembly at a fourth of the at least one pivoting hinged ramp;
a drive shaft, the drive shaft having a distal drive shaft component having threads for translating the distal ramp assembly and a proximal drive shaft component having threads for translating the proximal ramp assembly, wherein the distal drive shaft component is coupled to the proximal drive shaft component; and
wherein rotation of the drive shaft drives the distal ramp assembly and the proximal ramp assembly simultaneously in opposite directions to selectively expand or contract a distance between the first overlying base plate and the second lateral side of the frame.

US Pat. No. 11,026,811

ACETABULAR CUP PROSTHESIS ALIGNMENT SYSTEM AND METHOD

DEPUY SYNTHES PRODUCTS, I...

1. A system for aligning an acetabular prosthetic component in a patient's surgically prepared acetabulum, the system comprising:a reference sensor module securable to the patient's bony anatomy and including (i) a first orientation sensor configured to generate first sensor data indicative of the orientation of the patient's bony anatomy in three-dimensions, and (ii) a first communication circuit to transmit the first sensor data;
an inserter sensor module securable to an acetabular prosthetic component inserter, the inserter sensor module including (i) a second orientation sensor configured to generate second sensor data indicative of the orientation of the acetabular prosthetic component inserter in three-dimensions, (ii) a second communication circuit to transmit the second sensor data, and (iii) an alignment indicator;
a display module separate from the reference sensor module and the inserter sensor module, the display module including (i) a display, (ii) a third communication circuit configured to receive the first sensor data and the second sensor data, and (iii) a processing circuit to determine an orientation of an acetabular prosthetic component coupled to the acetabular prosthetic component inserter relative to the patient's bony anatomy based on the first sensor data and the second sensor data, display indicia of the determined orientation of the acetabular prosthetic component on the display, and communicate with the inserter sensor module to activate the alignment indicator in response to the determined orientation being within threshold amount of a reference orientation;
wherein the processing circuit of the display module is configured to determine a coordinate system conversion factor to convert the second sensor data from a coordinate system of the inserter sensor module to a patient coordinate system of the patient's bony anatomy and determine the orientation of the acetabular prosthetic component inserter relative to the patient's bony anatomy using the coordinate system conversion factor.

US Pat. No. 11,026,810

PROSTHESIS ALIGNMENT SYSTEM

Biomet Manufacturing, LLC...

1. A system for placement of an implant in a predetermined orientation, comprising:a rod extending from a first end to a second end;
a sleeve member extending from a proximal end to a distal end having a through bore extending through the sleeve member configured to slidably receive the rod; and
an alignment plate, comprising:
a body having an exterior-facing surface and an implant-facing surface;
a through bore extending at least partially through the body, the rod configured to extend through the through bore;
at least one adjustable finger extending in a direction transverse to a plane defined by the body; and
at least one patient-engaging surface positioned on the at least one adjustable finger, the at least one patient-engaging surface structured to be spaced radially outward of the implant and also spaced radially from the body, wherein the adjustable finger is adjustable to vary the distance between the patient-engaging surface and the implant-facing surface, wherein the patient-engaging surface is configured to engage a portion of a patient during placement of the implant to align the alignment plate relative to the patient in the predetermined orientation, wherein the patient-engaging surface is adjustable in a direction transverse to a plane defined by the body from a first position to a second position, such that the patient-engaging surface is configured to engage the portion of the patient in the second position,
wherein the distal end of the sleeve is configured to terminate at the alignment plate for placement of the implant.

US Pat. No. 11,026,809

PROSTHESIS INSTALLATION AND ASSEMBLY

Kambiz Behzadi, Pleasant...

1. A grasper for a head of a modular prosthesis having an opening to a bore complementary to a morse taper of a complementary trunnion of the modular prosthesis, the head including a planar face centered on the opening and a bore axis centered through the opening and aligned with the morse taper, comprising:a set of two or more pivoting gripping elements, each gripping element defining a portion of a spherical cavity disposed between a first edge and a second edge with said second edge defining a ledge complementary to a portion of the planar face when the head is disposed within said portion of said spherical cavity;
a clamp top rotatively coupled to said first edge of each said gripping element and defining a longitudinal clamp axis; and
a locking mechanism, coupled to said clamp top and operatively coupled to said set of pivoting gripping elements, said locking mechanism configured to secure said pivoting locking members in either a first mode or a second mode, said first mode configured to permit said set of pivoting gripping members to pivot about said clamp top to open and close and said second mode configured to secure said set of pivoting gripping members in a closed position while inhibiting said set of pivoting gripping members from transitioning to an opened position, said closed position configured to align an axis of said spherical cavity with said longitudinal clamp axis responsive to a collective interaction of said ledges with the planar face when the head is disposed within all said portions of said spherical cavity;
wherein said locking mechanism includes a lock ring that includes two positions, a locked position that engages with said set of pivoting gripping elements to inhibit their transition and an unlocked position that disengages from said set of pivoting gripping elements to permit their transition.

US Pat. No. 11,026,808

BONE GRAFTING AND COMPACTION

Alphatec Spine, Inc., Ca...

1. A tool for delivery and/or compaction of bone graft material comprising:a cannula with an inner lumen extending along a longitudinal axis from a hopper end of the cannula to a delivery tip of the cannula;
a hopper with an internal volume for storing bone graft material, wherein the hopper is connected to the hopper end of the cannula with the internal volume of the hopper in communication with the inner lumen of the cannula for delivery of bone graft material from the hopper to the delivery tip of the cannula;
an output shaft within the inner lumen extending along the longitudinal axis, the output shaft including a helical screw thread extending radially outward from the output shaft toward an inner surface of the cannula; and
an actuator connected to the hopper and to the output shaft to drive the output shaft rotationally relative to the hopper and to the cannula,
wherein the actuator is configured to drive motion of the output shaft that alternates between a first stroke motion including linear motion extending along the longitudinal axis to push bone graft material out of the inner lumen of the cannula and a second stroke motion including combined linear and rotary motion withdrawing in a direction toward the internal volume of the hopper so that continued alternating between the first stroke motion and the second stroke motion repeatedly moves bone graft material from the hopper to the delivery tip of the cannula, wherein in the first stroke motion the actuator is configured to extend the output shaft axially along the longitudinal axis in a direction out of the hopper for pushing bone graft material engaged with the helical screw thread out of the hopper and out of the inner lumen of the cannula, wherein for at least part of the first stroke motion, the actuator is configured to extend the output shaft axially along the longitudinal axis in a direction out of the hopper without rotating the output shaft.

US Pat. No. 11,026,807

EXPANDABLE, ANGULARLY ADJUSTABLE INTERVERTEBRAL CAGES

EIT Emerging Implant Tech...

1. An expandable spinal implant comprising:a body having an upper plate and a lower plate connected together by an elastically deformable hinge, each of the plates including an inner ramped surface, the implant further having a channel, wherein the body defines a leading end and a trailing end with respect to insertion into an intervertebral space; and
a lever pin disposed in the channel, the lever pin comprising a shaft having at one end a keyed surface, the lever pin further having at an opposed end an enlarged, shaped head, the shaped head further including an exterior adjustment surface configured to cooperate with the inner ramped surfaces of the plates upon rotation to urge the upper and lower plates apart,
wherein the lever pin has a length that spans a majority of a distance from the leading end to the trailing end, and the exterior adjustment surface spans a majority of the length of the lever pin.

US Pat. No. 11,026,806

INTERVERTEBRAL IMPLANT

DePuy Synthes Products, I...

1. A method of implanting an expandable intervertebral implant comprising:positioning the implant between two vertebral bodies via a transforaminal approach, wherein the implant comprises:
upper and lower body portions each having respective first and second surfaces, the first and second surfaces of the upper and lower body portions generally facing each other, wherein the upper and lower body portions are one-piece structures from their respective first surfaces to their respective second surfaces;
vertebral engaging projections that extend from the upper and lower body portions;
a threaded shaft disposed between the upper and lower body portions, the threaded shaft having a first end and a second end spaced from the first end in a select direction;
an outer sleeve threadedly coupled to the first end of the threaded shaft, wherein the outer sleeve supports a first wedge member that defines first ramp surfaces, and the outer sleeve extends out from the first wedge member in the select direction; and
a second wedge member carried by the threaded shaft at a location spaced from the first wedge member in the select direction, wherein the second wedge member defines second ramp surfaces sloped opposite the first ramp surfaces;
after the positioning step, causing relative rotation between the outer sleeve and the threaded shaft about a shaft axis so as to cause the first wedge member to threadedly move with respect to the threaded shaft toward the second wedge member, wherein the causing step forces 1) the first ramp surfaces against the first surfaces of the upper and lower body portions, and 2) the second ramp surfaces against the second surfaces of the upper and lower body portions, thereby increasing a distance between the upper and lower body portions; and
wherein the causing step causes an alignment projection to ride in an alignment opening, thereby restricting movement of the upper body portion relative to the lower body portion to a direction substantially perpendicular to the shaft axis.

US Pat. No. 11,026,805

EXPANDABLE INTERVERTEBRAL FUSION IMPLANT

1. An expandable intervertebral fusion implant, comprising:a first vertical member operatively arranged to extend;
an inferior component, including:
first longitudinal member including a first proximal end pivotably connected to the first vertical member and a first distal end; and,
a second longitudinal member including a second proximal end pivotably connected to the first vertical member and a second distal end, the second distal end being displaceable with respect to the first distal end; and,
a superior component, including:
a third longitudinal member including a third proximal end pivotably connected to the first vertical member and a third distal end; and,
a fourth longitudinal member including a fourth proximal end pivotably connected to the first vertical member and a fourth distal end, the fourth distal end being displaceable with respect to the third distal end;
wherein the superior component is operatively arranged to displace relative to the inferior component.

US Pat. No. 11,026,804

COAXIAL SCREW GEAR SLEEVE MECHANISM

SpineX Tec, LLC, Gering,...

1. A method comprising:placing a lifting device in a retracted state in which a first member of the lifting device is adjacent a second member of the lifting device; and
rotating a first sleeve rotatably coupled to the first member, which, in turn, non-rotatably translates a first post extending from the second member, thereby transitioning the lifting device to an expanded state in which the first and second members are spaced apart.

US Pat. No. 11,026,803

INTERVERTEBRAL SPACER

Globus Medical, Inc., Au...

1. An assembly for implant installation between adjacent vertebral bodies of a patient, comprising:an implant having a support body and a rotatable insert therein;
the support body having a proximal end portion and a distal end portion and the support body being configured and dimensioned for installation between adjacent vertebral bodies;
wherein the support body includes a superior surface and an inferior surface,
wherein the support body defines a longitudinal opening extending therethrough from the superior surface to the inferior surface and positioned in between the proximal end and the distal portion to accommodate the rotatable insert therein,
wherein the insert is rotatable about a central longitudinal axis within the longitudinal opening to permit the support body to rotate about the insert and the central longitudinal axis,
wherein in a first position the insert is rotationally fixed with respect to the support body and in a second position the support body may rotate with respect to the insert, and
wherein the insert includes a circumferential rib that mates to a corresponding indentation shaped on the support body,
wherein the support body further includes a groove that extends adjacent the proximal end portion and extends along an interior curved wall of the support body.

US Pat. No. 11,026,802

BONE PLATE STABILIZATION SYSTEM AND METHOD FOR ITS USE

RSB Spine LLC, Cleveland...

1. An apparatus, comprising:a base plate having a top surface, a bottom surface, and first and second ends, the base plate defining a plurality of bone anchor holes that each extend from the top surface toward one of the first and second ends, the plurality of bone anchor holes including a first bone anchor hole extending from the top surface and terminating in a first opening at least partially defined by the first end and a second bone anchor hole extending from the top surface and terminating in a second opening at least partially defined by the first end, the first end including a substantially flat portion extending from the first opening to the second opening; and
a chamber structure configured to be coupled to the base plate, the chamber structure configured to maintain disc space across a bone graft site between adjacent vertebral bones,
the base plate and the chamber structure configured to be implanted between the adjacent vertebral bones with (1) the base plate fitting primarily between anterior portions of the adjacent vertebral bones and (2) the chamber structure extending posteriorly from the base plate,
the base plate, when implanted, configured to bear weight along portions of the first and second ends of the base plate fitted between the anterior portions of the adjacent vertebral bones, while sharing weight with bone graft material placed between the adjacent vertebral bones and in a space at least partially defined by the chamber structure;
the top surface of the base plate is generally (1) flat and (2) of rectangular shape when viewed in an anterior-to-posterior direction.

US Pat. No. 11,026,801

MODULAR PLATE AND CAGE ELEMENTS AND RELATED METHODS

CTL Medical Corporation, ...

1. An interbody system for implanting between vertebrae, comprisinga cage body that includes a pair of sagittal walls, an aft-wall and a wall membrane that is made of a shape memory form material, and
an interbody device that attaches to the cage body, wherein the interbody device comprises an aperture that receives a bone fastener, and wherein the wall membrane bends under a force applied by the bone fastener.

US Pat. No. 11,026,800

EXPANDABLE VERTEBRAL IMPLANT

Global Medical Inc, Exto...

1. A method for therapeutically maintaining a separation of bones of a joint, comprising:inserting a spacer between bones of the joint, the spacer comprising:
a body member;
a translation member received in the body member;
an upper endplate having an upper plate portion comprising a bottom post;
a lower endplate having a lower plate portion comprising a top post;
an actuation member operably connected to the translation member, whereby movement of the actuation member in a first direction causes the translation member to increase the distance of separation between the upper endplate and the lower endplate; and
a first socket,
wherein in a contracted position the upper plate portion and the lower plate portion are configured to be received in the body member without exposing the top post and the bottom post;
positioning a first anchor configured to fasten the spacer to the patient, wherein the first anchor is received in the first socket.

US Pat. No. 11,026,799

ETHNIC-SPECIFIC ORTHOPAEDIC IMPLANTS AND CUSTOM CUTTING JIGS

ZIMMER, INC., Warsaw, IN...

1. An orthopedic implant comprising:a distal femoral component comprising a first condyle bearing surface having a first profile formed of a plurality of consecutive arcs of curvature selected based on an identified ethnic descent of a patient, the plurality of consecutive arcs selected as a single set of arcs including one of:
a first set of arcs including a total of three separate arcs of curvature corresponding with a patient being of Asian descent,
a second set of arcs including a total of four separate arcs of curvature corresponding with a patient being of African descent, or
a third set of arcs including a total of four separate arcs of curvature corresponding with a patient being of European descent; and
a proximal tibial component comprising a first condyle bearing surface having a second profile comprising at least three parallel arcs of curvature.

US Pat. No. 11,026,798

SHEET BASED TRIPLY PERIODIC MINIMAL SURFACE IMPLANTS FOR PROMOTING OSSEOINTEGRATION AND METHODS FOR PRODUCING SAME

RESTOR3D, INC., Durham, ...

1. A 3D-printed implant comprising:a top surface and a bottom surface;
a titanium frame comprising:
an interior portion, wherein the interior portion defines a void area; and
a titanium sheet-based triply periodic minimal surface (TPMS) portion integrally formed with the titanium frame via SLM 3D printing extending from the top surface through the void area of the titanium frame to the bottom surface, the TPMS portion comprising:
a wall density greater than 99%;
a stiffness modulus of about 3-14 GPa;
a porosity of about 55-85%; and
an ultimate compression strength of about 50-230 MPa.

US Pat. No. 11,026,797

JOINT IMPLANT PART, JOINT ENDOPROSTHESIS AND METHOD FOR PRODUCING A JOINT IMPLANT PART AND A JOINT ENDOPROSTHESIS

Aesculap AG, Tuttlingen ...

1. A joint implant part of a joint endoprosthesis, comprising:at least one first volume region,
at least one second volume region, and
at least one third volume region,
the at least one first volume region defining a bone contact surface region with at least one bone contact surface, the at least one second volume region defining a joint surface region with at least one joint surface, and the at least one third volume region does not contact a bone surface or a joint surface in an implanted position,
wherein:
a modulus of elasticity of at least one of the at least one first, second, and third volume regions varies in at least one spatial direction,
the at least one first, second, and third volume region each comprises a plurality of cavities,
a total volume defined by the plurality of cavities in an entirety of the at least one third volume region is greater than a total volume defined by the plurality of cavities in an entirety of the at least one first volume region and greater than a total volume defined by the plurality of cavities in an entirety of the at least one second volume region;
compared total volumes of the at least one first volume region, the at least one second volume region and the at least one third volume region are identical in size, and
an average total volume defined by the plurality of cavities in the at least one first volume region increases starting from the at least one bone contact surface in a direction towards the at least one third volume region, an average total volume defined by the plurality of cavities in the at least one third volume region has a maximum in the at least one third volume region, and an average total volume defined by the plurality of cavities in the at least one second volume region decreases in a direction towards the at least one joint surface.

US Pat. No. 11,026,796

ROBOTIC BONE PREPARATION FOR INCREASING IMPLANT CONTACT SURFACE AREA

Mako Surgical Corp., For...

1. A bone implant comprising:a proximal surface; and
a distal surface having a wave pattern with alternating curved peaks and curved valleys, each valley connecting adjacent peaks,
wherein the distal surface is adapted to engage with an outer surface of a bone, and
wherein each peak extends towards the proximal surface in a proximal direction and each valley extends away from the proximal surface in a distal direction,
wherein the wave pattern on the distal surface of the implant is configured to match a wave pattern on the outer surface of the bone, such that the alternating peaks and valleys of the respective implant are configured to align with the respective peaks and valleys of the bone wave pattern.

US Pat. No. 11,026,795

GRAFT COLLECTION AND CONTAINMENT SYSTEM FOR BONE DEFECTS

DEPUY SYNTHES PRODUCTS, I...

1. A device for containing bone graft material, comprising:a first shell member defining a first portion of an inner sleeve and a first portion of an outer sleeve to form a first bone graft collecting space therebetween;
a second shell member defining a second portion of the inner sleeve and a second portion of the outer sleeve to form a second bone graft collecting space therebetween, the first portion of the inner sleeve and the first portion of the outer sleeve of the first shell being openable and closable relative to the second portion of the inner sleeve and the second portion of the outer sleeve of the second shell such that, in a closed configuration, a contour of the outer sleeve substantially matches a contour of an exterior of a bone about which the device is to be employed.

US Pat. No. 11,026,793

SYSTEMS AND METHODS FOR MAGNETIC INDUCTION OF A PENILE PROSTHESIS

The Board of Trustees of ...

1. A magnetic induction apparatus for generating heat in a shape memory alloy penile prosthesis, the apparatus comprising:a power source for generating a current;
a sheath having a length extending from a first end to a second end and including a bore configured to receive an entire length of the penile prosthesis, the bore extending the length of the sheath; and
a coil operatively connected to the power source for receiving the current, wherein the current in the coil generates an alternating magnetic field which induces eddy currents and generates heat in the penile prosthesis to change the penile prosthesis from a flaccid state to a rigid state.

US Pat. No. 11,026,792

LEAFLET-GROUPING SYSTEM

CARDIOVALVE LTD., Or Yeh...

1. A method for grouping prosthetic valve leaflets of an aggregate of prosthetic valve leaflets, the method comprising, using a computer processor:for each leaflet of the aggregate, in response to an image parameter of the leaflet, deriving a leaflet-flexibility value;
receiving a group size value;
designating at least some of the leaflets of the aggregate into designated leaflet groups, (i) based on similarity between the respective leaflet-flexibility value of each leaflet of the aggregate, and (ii) such that each of the designated leaflet groups includes a number of leaflets equal to the group size value; and
outputting an indication of the designated leaflet groups.

US Pat. No. 11,026,791

FLEXIBLE CANOPY VALVE REPAIR SYSTEMS AND METHODS OF USE

MEDTRONIC VASCULAR, INC.,...

1. A system for treating valvular regurgitation in a heart valve, the system including a delivery configuration and a deployed configuration, the system comprising:a flexible canopy including a first surface and a second surface opposite the first surface;
an elongated tether configured to be placed under tension in situ, the elongated tether including an elastic portion and an inelastic portion coupled to the elastic portion, wherein the elastic portion is at least as long as the inelastic portion with a ratio of the elastic portion to the inelastic portion being between 50/50 and 70/30 and a proximal end of the elongated tether is attached to a distal end of the flexible canopy; and
a distal anchor configured to be embedded into tissue of a ventricle, wherein a distal end of the elongated tether is coupled to the distal anchor,
wherein when the system is in the deployed configuration, a proximal end of the flexible canopy is anchored to an annulus of the heart valve and the distal end of the elongated tether is anchored to tissue of a ventricle via the distal anchor such that the first surface of the flexible canopy overlays an underlying first surface of a first leaflet of the heart valve, and the elongated tether is placed under tension such that the system is configured to prevent the first leaflet of the heart valve from prolapsing, and to permit a portion of the second surface of the flexible canopy to coapt with at least an opposing mating portion of a second leaflet of the heart valve.

US Pat. No. 11,026,790

REPLACEMENT MITRAL VALVES

Cephea Valve Technologies...

1. A prosthetic mitral valve comprising:a valve support assembly configured to self-expand from a collapsed configuration to an expanded configuration and including an anchor assembly having a ventricular anchor, a central portion, and an atrial anchor, the anchor assembly including a plurality of diamond-shaped cells;
a plurality of leaflets attached to the valve support assembly; and
a plurality of retention hooks attached to the anchor assembly, when the valve support assembly is in the expanded configuration, each retention hook curving radially outwards and extending from an apex of a respective one of the plurality of diamond-shaped cells.

US Pat. No. 11,026,789

SYSTEM TO ASSIST IN THE RELEASE OF A COLLAPSIBLE STENT FROM A DELIVERY DEVICE

St. Jude Medical, Cardiol...

1. A delivery device for an implantable medical device having a plurality of retention members at an end thereof, the delivery device comprising:a shaft extending in a longitudinal direction and defining a longitudinal axis;
an elongated sheath surrounding a longitudinal portion of the shaft, the sheath being slidable relative to the shaft in the longitudinal direction;
a compartment defined inside the sheath and adapted to receive the medical device in an assembled condition;
a retainer positioned at one end of the compartment, the retainer including a plurality of circumferentially spaced recesses, each of the recesses having a bottom surface and a plurality of sidewalls, each of the recesses being adapted to receive one of the retention members of the medical device in the assembled condition; and
an energy storage element configured to be radially compressed by the medical device when the elongated sheath covers the compartment containing the medical device, the energy storage element being a plurality of recess inserts, each of the recess inserts including a compressible elastomeric material overlying and attached to the bottom surface of a respective one of the recesses so that the compressible elastomeric material is sandwiched between the bottom surface of the respective one of the recesses and one of the retention members of the medical device when the medical device is in the assembled condition the compressible material exerting a sufficient force to assist in ejecting the retention members from the recesses when the elongated sheath no longer covers the compartment.

US Pat. No. 11,026,788

LOADER AND RETRIEVER FOR TRANSCATHETER HEART VALVE, AND METHODS OF CRIMPING TRANSCATHETER HEART VALVE

Edwards Lifesciences Corp...

1. A loader assembly for loading a transcatheter heart valve into a delivery sheath for delivering the heart valve into a body of a patient, the loader assembly comprising:a loader tube having a first end, a second end, and a central axis extending through the first and second ends, the loader tube comprising a tube wall defining a coaxial bore, wherein the tube wall has a first section at the first end with a first inner diameter, a second section connected to a distal end of the first section and having a second inner diameter smaller than the first inner diameter, and a third section connected to a distal end of the second section and having a third inner diameter greater than the second inner diameter;
a hub in direct contact with and attached to at least an outer surface portion of the first section of the loader tube;
a cap directly coupled to a proximal-most end of the hub; and
at least one seal disposed in the cap and positioned proximal to the loader tube, the seal being configured to maintain hemostasis in the loader tube when the coaxial bore of the loader tube is in communication with a blood vessel of the patient;
wherein the tube wall has a first tapered section between the first section and the second section, wherein the first tapered section has an inner surface that tapers in a direction extending from the first end towards the second end of the loader tube;
wherein the tube wall has a second tapered section between the second section and the third section, wherein the second tapered section has an inner surface that tapers in a direction extending from the second end towards the first end of the loader tube, wherein the inner surface of the second tapered section progressively and continuously tapers from a proximal end of the third section to the distal end of the second section.

US Pat. No. 11,026,787

HEART VALVE HOLDER

St. Jude Medical, Cardiol...

1. A holder for a prosthetic heart valve, the holder comprising:a hub having an outer surface extending about a longitudinal axis;
a commissure support extending downward from the hub; and
a plurality of legs extending outward from the hub in first radial directions, each leg having a foot extending in a longitudinal direction generally parallel to the longitudinal axis, each foot having:
an inner surface, an outer surface, and a bottom; and
a structure defining two channels on the outer surface of the foot, each channel extending from a closed end at a spaced distance from the bottom of the foot to an open end at the bottom of the foot, each channel defining a concave inner surface, the structure further defining two suture holes each spaced apart from the bottom of the foot and extending between the inner surface and the outer surface of the foot.

US Pat. No. 11,026,786

PROSTHETIC HEART VALVE HAVING IDENTIFIERS FOR AIDING IN RADIOGRAPHIC POSITIONING

Medtronic, Inc., Minneap...

1. A method comprising the steps of:providing a valve prosthesis that includes a prosthetic heart valve and at least one commissural post formed of a material, the prosthetic heart valve being coupled to the at least one commissural post, the at least one commissural post being provided with a radiographic identifier that is shaped to be reflection-asymmetric about an axis of the at least one commissural post that is generally parallel with the central longitudinal axis of the valve prosthesis wherein the at least one commissural post is shaped to define an opening through a thickness of the material of the at least one commissural post such that the opening does not include the material of the at least one commissural post, the opening defining an entirety of the radiographic identifier such that the radiographic identifier is bounded by the material of the at least one commissural post and is void of the material of the at least one commissural post, the opening having a reflection-asymmetric shape about the axis of the at least one commissural post, and even further wherein a radiopacity of the valve prosthesis at the radiographic identifier is less than a radiopacity of the material of the at least one commissural post;
while the valve prosthesis is in the collapsed position, placing, via a blood vessel of the subject, the valve prosthesis at least partially in a heart of a subject in a vicinity of a native heart valve having native commissures;
generating a fluoroscopic image of the native commissures and valve prosthesis; and
rotationally aligning the radiographic identifier visible in the image with at least one of the native commissures;
wherein rotationally aligning comprises:
rotating the valve prosthesis;
observing whether the radiographic identifier appears to move in the image in the same direction that the valve prosthesis is rotated, or in an opposite direction; and
if the radiographic identifier appears to move in the image in the opposite direction, rotating the valve prosthesis to correct a rotational alignment of the valve prosthesis.

US Pat. No. 11,026,785

MECHANICALLY EXPANDABLE HEART VALVE

Edwards Lifesciences Corp...

1. A prosthetic valve assembly comprising:an annular frame being radially expandable and compressible between a radially compressed configuration and a radially expanded configuration;
a valvular structure comprising a plurality of leaflets mounted inside the annular frame, wherein each two adjacent leaflets form a pair of commissure tabs;
a plurality of posts mounted on an interior surface of the annular frame; and
a pair of commissure attachment members extending outwardly from each post and away from each other, wherein a tangent line that is tangent to a circumference of the frame at the post forms an acute angle relative to each corresponding commissure attachment member, wherein each pair of commissure tabs is attached to a corresponding pair of the commissure attachment members.

US Pat. No. 11,026,784

STENTLESS SUPPORT STRUCTURE

HLT, Inc., Maple Grove, ...

1. A prosthetic heart valve comprising:a first wire braided to form a tubular support structure having an elongated configuration and a folded configuration, said first wire heat set to be biased toward said folded configuration;
a second wire formed into an annular wire form having a plurality of commissural points;
a material attached to said annular wire form to create valve leaflets that remain open when fluid flows through the leaflets in a first direction and coapt to stop fluid from flowing through them when said fluid flows in a second direction, opposite said first direction.

US Pat. No. 11,026,783

REPLACEMENT MITRAL VALVES

Cephea Valve Technologies...

1. A replacement mitral valve, comprising:a self-expandable valve assembly comprising an anchor assembly having a ventricular anchor, a central portion, and an atrial anchor, the valve assembly having a collapsed configuration and a self-expanded configuration in which the ventricular anchor and the atrial anchor are flared radially outward relative to the central portion, the atrial anchor having a larger maximum diameter than a maximum diameter of the ventricular anchor when the valve assembly is in the self-expanded configuration prior to delivery, the valve assembly including an annular strut frame disposed radially inward of the anchor assembly and attached to the atrial anchor of the anchor assembly in the collapsed configuration, wherein the anchor assembly and the annular strut frame are unitary; and
a plurality of replacement leaflets secured to the valve assembly.

US Pat. No. 11,026,782

HEART CHAMBER PROSTHETIC VALVE IMPLANT WITH ELEVATED VALVE SECTION AND SINGLE CHAMBER ANCHORING FOR PRESERVATION, SUPPLEMENTATION AND/OR REPLACEMENT OF NATIVE VALVE FUNCTION

4C Medical Technologies, ...

1. A device for expanded implantation within a heart chamber that is in fluid communication with an annulus comprising an annular plane and with a native valve having leaflets, the expanded and implanted device comprising:a base section comprising a lower surface that is configured to be at least partially disposed on the annular plane, the lower surface comprising a raised portion configured to be spaced above the lower surface of the base section and the annular plane;
an atrial dome section configured to be in pressured and frictional engagement with a roof of the heart chamber when the device is expanded and implanted;
an intermediate section comprising an expandable mesh and operatively attached to the base section and the atrial dome section; and
a central cylinder valve support comprising a lower surface, the central cylinder valve support operatively attached to the raised portion of the base section and comprising at least one prosthetic valve leaflet operatively attached therein, the lower surface of the central cylinder valve support spaced above the lower surface of the base section.

US Pat. No. 11,026,781

VALVE ANCHOR AND INSTALLATION METHOD

Edwards Lifesciences Corp...

1. A system for securing a prosthetic valve at a native valve, comprising:an expandable/collapsible anchor device having a lower portion below an upper portion, the lower portion having an expandable tubular body about a vertical axis and comprising undulating struts, the tubular body defining at least two leaflet clamping portions each defined by at least one peak extending upward, wherein there are at least two downward valleys on the lower portion, one downward valley each on both sides of and adjacent the at least two leaflet clamping portions, the anchor device further including two and only two upstanding vertical posts each commencing at one of the at least two downward valleys and extending upward beyond a maximum height of the at least one peak of the leaflet clamping portion and terminating in the upper portion, wherein the lower portion further includes two or more integrally formed downwardly extending legs that extend downward below the valleys in buckles to facilitate manipulation and deployment of the anchor device.

US Pat. No. 11,026,780

CARTRIDGE FOR AN INJECTOR FOR IMPLANTING AN INTRAOCULAR LENS

IOLUTION GMBH, Hamburg (...

1. An injector system for implanting a lens into an eye, comprising:an injector body having a front end and a rear end;
a cannula arranged at the front end of the injector body, which provides a transport channel for the lens to be implanted;
a cartridge comprising a receiving region for the lens and at least one movable haptic slider for displacing a lens haptic within the cartridge, wherein the cartridge is arranged such that the lens can be fed into the transport channel;
a folding body insertable into the cartridge and receiving region of the lens, for pushing the lens into the transport channel in such a manner that the lens is foldable around the folding body; and
a slider arranged within the injector body so as to be displaceable, and which can be pushed through the front end of the injector body and into the transport channel in such a way that the lens can be ejected from the transport channel,
wherein the haptic slider is mounted to the cartridge so as to be movable.

US Pat. No. 11,026,779

INTRAOCULAR LENS AND METHODS FOR IMPLANTING THE SAME

1. A method of implanting an intraocular lens in a human eye having a ciliary sulcus, a lens capsule with an anterior portion and a posterior portion, a natural lens nucleus, a cortex and an anterior hyaloid membrane, the method comprising the steps of:performing a continuous curvilinear capsulotomy of the anterior portion of the lens capsule;
removing the natural lens nucleus and cortex from the lens capsule;
polishing the anterior portion and posterior portion of the lens capsule;
placing a viscoelastic OVD in the ciliary sulcus to flatten the anterior and posterior portions of the lens capsule together in a substantially horizontal plane;
performing a continuous curvilinear capsulotomy of the posterior portion of the lens capsule; and
implanting an intraocular lens in the eye, the intraocular lens having a generally circular, central lens body having first and second, opposite posterior and anterior surfaces, at least one of said surfaces having an arcuate cross-sectional configuration for providing vision correction for the eye, said posterior and anterior surfaces meeting in a rounded peripheral side surface, said central lens body having at least two haptics extending from said peripheral side surface of said central lens body, each of said at least two haptics having an arcuate configuration so that a radially distal end of each haptic is engageable within the ciliary sulcus of the eye for (i) stabilizing said central lens body at a location posterior of both the lens capsule anterior and posterior portions, and (ii) sealing the anterior and posterior portions together proximal to each capsulotomy in said anterior portion and said posterior portion, wherein the step of implanting said lens in the eye includes locating said at least two haptics within the ciliary sulcus and further locating said central lens body through both of said capsulotomies into a Berger's space.

US Pat. No. 11,026,778

KERATOPROSTHESIS APPARATUSES, SYSTEMS, AND METHODS

Massachusetts Eye and Ear...

1. A keratoprosthesis apparatus comprising:a circular backplate composed, at least in part, of a titanium alloy, wherein the circular backplate includes an annular rim portion having a central aperture extending therethrough;
a first plurality of tabs positioned along the annular rim portion and extending radially inwardly into the aperture; and
a plurality of flexible appendages extending radially outwardly from the annular rim portion and positioned along the annular rim portion at locations corresponding to the first plurality of tabs, wherein the plurality of flexible appendages is configured to provide leverage to pivot the first plurality of tabs outwardly.

US Pat. No. 11,026,777

LAYERED MEDICAL APPLIANCES AND METHODS

Merit Medical Systems, In...

1. A multilayered vascular prosthesis, comprising:a luminal surface comprising a serially deposited fiber layer; and
an expanded polytetrafluoroethylene (ePTFE) layer coupled to the serially deposited fiber layer, wherein,
the ePTFE layer comprises one or more sublayers of ePTFE, and
an axis of longitudinal expansion of at least one of the ePTFE sublayers is disposed at an angle to an axis of longitudinal expansion of at least one adjacent ePTFE sublayer;
wherein at least one of the ePTFE sublayers is configured to be impermeable to red blood cell migration; and
wherein the one or more sublayers of ePTFE comprise different average pore sizes.

US Pat. No. 11,026,776

OPTIMAL SIZING OF ILIAC VEIN STENTS AND METHOD OF USING

1. A method of diagnosing and treating diffuse stenosis, comprising:a. Using a duplex ultrasound (DUS) to measure a cross-sectional area of a vein portion of a patient; and
b. making a determination that the cross-sectional area is less than or equal to 90% of a calculated predetermined mean cross-sectional area fora vein segment in which the vein portion is located, where the calculated predetermined cross-sectional area is not measured from or determined from any said vein portion of said patient, or measured or determined cross sectional area of any non-stenotic vein portion in any other patient, examining the vein portion with intravascular ultrasound (IVUS) to determine an IVUS cross-sectional area of the vein portion; and
c. making a determination that the measured IVUS cross-sectional area is less than 50% of the predetermined mean cross-sectional area for the vein segment in which the vein portion is located, treat the vein portion by stenting.

US Pat. No. 11,026,775

TEXTURED SURFACES FOR BREAST IMPLANTS

Establishment Labs S.A., ...

1. A breast implant comprising a textured surface having, at an area scale of 1 mm×1 mm:a mean surface roughness Sa value of from 5 ?m to 7 ?m;
a root mean square height Sq value of from 5 ?m to 10 ?m;
a mean surface skewness Ssk value of from ?0.4 to +0.4; and
a mean excess kurtosis value (Sku minus 3) of from ?0.7 to +0.7;
wherein the surface comprises a biocompatible polymer.

US Pat. No. 11,026,774

HERNIA REPAIR PROSTHESES

THT BIO-SCIENCE, SOCIETE ...

1. A prosthesis for repair of an inguinal hernia, configured to be implanted preperitoneally by endoscope or open surgery, comprising openwork fabric of biocompatible material, comprising a first surface, called parietal surface, configured to be placed facing biological tissues of the inguinal region, and a second surface, opposite the first surface, called peritoneal surface, configured to be placed facing the peritoneum and the anterior face of the bladder, wherein the peritoneal surface comprises, on a portion of the surface thereof, a first zone provided with a non-stick coating, the parietal surface comprising, on a portion of the surface thereof, a second zone provided with a non-stick coating, the prosthesis being rectangular in shape, the first zone is extended over the full width of the prosthesis from one lateral edge of the prosthesis, the second zone is extended over a width of between one-third and one-half of the width of the prosthesis; wherein the first zone and the second zone are not substantially disposed one above the other, when the prosthesis is viewed from a top side.

US Pat. No. 11,026,773

ANIMAL SUPPORTING DEVICE

MY FAVORITE GROOMER, For...

1. An animal supporting device comprising a block having a first end, an opposing second end, and first and second pairs of opposed side ends extending between said first and second ends; said block having three primary dimensions of unequal lengths at generally regular length intervals; said block further having a plurality of non-opposing ends with a generally trough-shaped channel creating a channel portion and non-channel portions, wherein each channel depth is between about one-third and about two-thirds of the regular length interval; whereby said block can be placed beneath an animal and oriented such that the non-channel portions of the ends can engage the abdomen or other body part of the animal at elevations corresponding to said primary dimensions when those ends are positioned as the uppermost end, and the channel portions of the ends can engage the abdomen or other body part of the animal at elevations less than those of the corresponding non-channel portions when those ends are positioned as the uppermost end and the channel portion aligns with the torso or body part of the animal, such that said block can provide various support heights.

US Pat. No. 11,026,772

DRIVE TRAIN ASSEMBLY FOR AN ORAL CARE DEVICE

KONINKLIJKE PHILIPS N.V.,...

1. A drive train assembly for an oral care device, the oral care device having a housing, the drive train assembly comprising:a plurality of elongated leaf spring assemblies symmetrically disposed around the circumference of the drive train assembly, wherein each of the plurality of elongated leaf spring assemblies comprises a leaf spring with a first segment, a second segment, and an additional segment, wherein the additional segment is disposed substantially orthogonal to the first segment and the second segment;
a first end mount and a second end mount, wherein the plurality of elongated leaf spring assemblies are secured at a first end to the first end mount and at a second end to the second end mount; and
a ring encircling the plurality of elongated leaf springs assemblies, wherein the ring is fixedly connected to each of the plurality of elongated leaf springs assemblies and configured to be fixedly connected to the housing of the oral care device.

US Pat. No. 11,026,771

INTERDENTAL CLEANING INSTRUMENT

KOBAYASHI PHARMACEUTICAL ...

1. An interdental cleaning instrument comprising:a base part having a shape extending from a base end to an insertion end section in an axial direction of the interdental cleaning instrument, and having a first hardness; and
a cleaning part that is composed of an elastomer having a second hardness lower than the first hardness of the base part, covers at least a portion of the base part from the insertion end section, and is capable of cleaning an interdental space, wherein
the base part has:
a grip part that extends from the base end along the axial direction and has a shape to receive a grasp of fingers; and
a shaft part which has a shape that is insertable to an interdental space between neighboring teeth, and has the insertion end section and a base end section at which the grip part is connected to the shaft part;
the shaft part has a shape that can be flexurally deformed to displace the insertion end section in a direction which is perpendicular to the axial direction of the shaft part with respect to the base end section;
the cleaning part has a shape that covers the insertion end section to form a tip end of the cleaning part and a portion of the shaft part extending from the insertion end section by a length equal to or less than the entire axial dimension of the shaft part;
the base part has an in the axial dimension of 35 mm or more; and
the shape of the base part is set to obtain a first pressing force ranged from 0.3 N to 1.4 N to cause 10 mm of displacement at a first portion distant by 2.5 mm from the tip end of the cleaning part when the first pressing force is applied to the first portion in a state in which the interdental cleaning instrument is fixedly held at a portion 10 mm apart from the tip end of the cleaning part to the grip part side; and
a second pressing force ranged from 0.5 N to 2.5 N to cause 10 mm of displacement at a second portion distant by 8.0 mm from the tip end of the cleaning part when the second pressing force is applied to the second portion in a state in which the interdental cleaning instrument is fixedly held at a portion 35 mm apart from the tip end of the cleaning part to the grip part side.

US Pat. No. 11,026,770

SYSTEM AND METHOD FOR IMPROVED INTRA-ORAL SCANNING PROTOCOL AND CALIBRATION

Biomet 3I, LLC, Palm Bea...

1. A method of providing a three-dimensional scan of a dental arch area, the dental arch area having two segments and a soft tissue, homogeneous, cross-arch connecting area between the two segments, the method comprising:receiving, at a computing device, a scan dataset of a portion of a patient's mouth including data regarding the two segments, the soft tissue, homogeneous, cross-arch connecting area, and a connecting-geometry tool with at least one definable feature relative to the dental arch area, the at least one definable feature overlaying at least part of the soft tissue, homogeneous, cross-arch connecting area;
determining data relating to the at least one definable feature of the connecting-geometry tool overlaying the soft tissue, homogeneous, cross-arch connecting area based on the scan dataset of the portion of the patient's mouth; and
determining the dimensions of the soft tissue, homogeneous, cross-arch connecting area based on the data relating to the at least one definable feature.

US Pat. No. 11,026,769

DENTAL INSERT

1. A combination, comprising:a dental implant that integrates with the bone of the maxilla or mandible to support a dental prosthesis, the dental implant having an abutment to provide as an external connection, the abutment having a screw access channel;
a dental insert, comprising:
a spherical body of a medical grade elastomer, the body having a circumference with a plurality of outwardly extending projections of uniform size and shape distributed evenly about the circumference, the body being not more than 10 mm in diameter, as measured from an outer extremity of the projections;
wherein the dental insert is inserted into the screw access channel to prevent contaminants from entering the screw access channel.

US Pat. No. 11,026,768

DENTAL APPLIANCE REINFORCEMENT

Align Technology, Inc., ...

1. A dental appliance system, comprising:a series of dental appliances adapted to apply forces to a patient's teeth for moving the patient's teeth in accordance with a treatment path, the series of dental appliances including a first dental appliance associated with a first segment of the treatment path and a second dental appliance associated with a second segment of the treatment path, wherein each of the first and second dental appliances includes:
a shell formed from a polymeric material having tooth apertures arranged in an arch shape based at least in part on the patient's dental arch, the shell comprising:
at least one first arch-shaped rib integrally formed with the shell from the polymeric material and located on a lingual exterior surface of the shell, the at least one first arch-shaped rib following a contour of the lingual exterior surface of the shell along a first height of the shell; and
at least one second arch-shaped rib integrally formed with the shell from the polymeric material and located on a labial exterior surface of the shell, the at least one second arch-shaped rib following a contour of the labial exterior surface of the shell along a second height of the shell different than the first height,
wherein a thickness of the polymeric material of the shell at a location of the first arch-shaped rib or the second arch-shaped rib is larger than a thickness of the polymeric material of remaining portions of the shell that do not include the first or second arch-shaped rib;
wherein the first and second arch-shaped ribs of the first dental appliance cooperate and are digitally modelled with the shell of the first dental appliance to determine and apply a first set of forces onto the patient's teeth to achieve a first pre-calculated displacement of the patient's teeth in accordance with the first segment of the treatment path, wherein the first and second arch-shaped ribs of the second dental appliance cooperate and are digitally modelled with the shell of the second dental appliance to determine and apply a second set of forces onto the patient's teeth to achieve a second pre-calculated displacement of the patient's teeth in accordance with the second segment of the treatment path, wherein the first pre-calculated displacement is different than the second pre-calculated displacement.

US Pat. No. 11,026,767

SYSTEMS AND METHODS FOR PLANNING AN ORTHODONTIC TREATMENT

Oxilio Ltd, Larnaca (CY)...

1. A method for determining an orthodontic treatment based on generating a 3D representation of a given tooth of a subject, the given tooth including a crown portion and a root portion, the method being executable by a processor, the method comprising:acquiring a 3D representation of the crown portion of the given tooth,
the 3D representation of the crown portion being associated with a predetermined longitudinal tooth axis;
generating a 3D representation of the root portion of the given tooth by executing the steps of:
determining a location of a root apex of the 3D representation of the root portion relative to the predetermined longitudinal tooth axis, the determining being based on a predetermined instruction for locating the root apex;
generating, in a reference plane dissecting the predetermined longitudinal tooth axis and based on the 3D representation of the crown portion, a closed curve on the 3D representation of the crown portion,
segmenting the closed curve into a plurality of sub-curves;
for each one of the plurality of sub-curves, based on the root apex and the predetermined longitudinal tooth axis, generating a respective segment of a plurality of segments of the 3D representation of the root portion, the plurality of segments of the 3D representation of the root portion comprising a totality thereof;
merging the 3D representation of the crown portion with the 3D representation of the root portion, thereby generating the 3D representation of the given tooth; and
determining, based on the 3D representation of the given tooth, the orthodontic treatment for the subject.

US Pat. No. 11,026,766

PHOTO REALISTIC RENDERING OF SMILE IMAGE AFTER TREATMENT

Align Technology, Inc., ...

1. A method of orthodontically treating a patient's teeth comprising:receiving facial image of the patient that depicts the patient's teeth;
receiving a 3D model of the patient's teeth;
determining color palette of the depiction of the patient's teeth;
coding 3D model of the patient's teeth based on attributes of the 3D model;
providing the 3D model, the color palette, and the coded 3D model to a neural network;
processing the 3D model, the color palette, and the coded 3D model by the neural network to generate a processed image of the patient's teeth;
simulating specular highlights on the processed image of the patient's teeth; and
inserting the processed image of the patient's teeth into a mouth opening of the facial image.

US Pat. No. 11,026,765

STABILIZED, WATER-JET SLURRY APPARATUS AND METHOD

H2O Tech, Inc., Spanish ...

1. A method for cutting a dental material, comprising:forming a hydrated polymerized acrylic acid by mixing water and a polymerized acrylic acid;
neutralizing the hydrated polymerized acrylic acid with a base to ionize and uncoil the polymer chains of the polymerized acrylic acid to obtain a neutralized polymerized acrylic acid solution for use in the mouth of a patient;
mixing an abrasive media with the neutralized polymerized acrylic acid to make a slurry comprising 5 to 30 wt % abrasive media and 0.05 to 0.5 wt % of the polymerized acrylic acid, wherein the abrasive media is mechanically suspended by polymer chains of the neutralized polymerized acrylic acid for at least one month;
delivering the slurry to a nozzle, wherein the abrasive media remains suspended by the polymer chains of the neutralized polymerized acrylic acid; and
expelling the slurry through the nozzle onto the dental material in the mouth of a patient with sufficient force so that the polymer chains of the neutralized polymerized acrylic acid are sheared, thereby reducing buildup of the neutralized polymerized acrylic acid on the dental material.

US Pat. No. 11,026,764

CANNULA ASSEMBLIES FOR USE WITH ROBOTIC SURGICAL SYSTEMS

COVIDIEN LP, Mansfield, ...

1. A surgical cannula assembly for use with a mounting structure of a robotic arm, the surgical cannula assembly comprising:a cannula configured for reception of a surgical instrument at least partially therethrough;
an attachment mechanism configured to releasably engage the cannula; and
a barrier configured to extend through a channel of the mounting structure, the barrier including a proximal ring for positioning adjacent a proximal face of the mounting structure, a distal ring for positioning adjacent a distal face of the mounting structure, and a cylindrical section defining a lumen therein and extending between the proximal ring and the distal ring, the cannula configured for insertion within the lumen in a distal-to-proximal direction; wherein the cannula is configured for removal from the lumen in a distal-to-proximal direction.

US Pat. No. 11,026,763

PROJECTION MAPPING APPARATUS

FUJIFILM Corporation, To...

1. A projection mapping apparatus comprising:a light source that emits measurement light to irradiate a subject with the measurement light;
a distance image sensor in which a plurality of light receiving elements are two-dimensionally arranged, wherein an amount of measurement light received by each light receiving element of the plurality of light receiving elements two-dimensionally arranged in the distance image sensor is dependent on a distance between each light receiving element and a surface of the subject, the distance image sensor outputting the amount of measurement light received by each element as a received light signal to a processor, the processor configured to:
acquire the received light signal outputted by the distance image sensor and generate a distance image on the basis of the acquired received light signal;
acquire a position of a leading end of a medical instrument inserted into the subject and determine a corresponding part of the subject which corresponds to the position of the leading end of the medical instrument in the subject;
acquire, as a leading end position image indicating the position of the leading end of the medical instrument in the subject, a transmission image of the corresponding part of the subject;
detect unevenness of a surface shape of the corresponding part of the subject on the basis of the generated distance image; and
transform the transmission image of the corresponding part of the subject to a shape fitted to the detected unevenness of the surface shape of the corresponding part of the subject to generate a projection image fitted to the surface shape of the corresponding part of the subject; and
a projector including a display optical element that displays the generated projection image, a projection light source that emits projection light so as to be incident on the display optical element, and a projection lens that projects the projection image emitted from the display optical element to the surface of the corresponding part of the subject.

US Pat. No. 11,026,762

MEDICAL OBSERVATION DEVICE, PROCESSING METHOD, AND MEDICAL OBSERVATION SYSTEM

SONY OLYMPUS MEDICAL SOLU...

1. A medical observation device, comprising:processing circuitry configured to
detect a pressing operation based on an operation signal according to the pressing operation output from an external operation device equipped with a switch pressed by a mouth; and
perform a process of controlling the medical observation device corresponding to the detected pressing operation, wherein
the process corresponding to the pressing operation includes some or all of a process related to an imaging operation of an imaging device, a process related to a display of a medical captured image which is captured in the imaging device, and an identification process of identifying a user's input indicating the process related to the imaging operation or the process related to the display of the medical captured image,
the processing circuitry is further configured to
switch to a mode for performing the identification process based on the detection of the pressing operation,
perform a process corresponding to the user's input identified by the identification process,
perform a voice recognition process of recognizing voice, as the identification process, on a voice signal output from a voice input device, and
perform a process corresponding to the recognized voice.

US Pat. No. 11,026,761

METHODS OF DETERMINING A RELATIVE STATE OF CHARGE OF A BATTERY FOR A SURGICAL INSTRUMENT AND SURGICAL INSTRUMENTS AND COMPUTER-READABLE MEDIA IMPLEMENTING THE SAME

Covidien LP, Mansfield, ...

1. A surgical instrument, comprising:an end effector configured to treat tissue with ultrasonic energy;
a user interface for receiving an input;
a generator coupled to the end effector;
a battery in communication with the generator; and
a controller coupled to the battery, the controller including:
a processor; and
a memory coupled to the processor, the memory storing a plurality of discharge profiles and having instructions stored thereon which, when executed by the processor, cause the processor to:
detect an input at the user interface,
in response to the detected input at the user interface, match a discharge profile among the plurality of discharge profiles to the detected input, the discharge profile corresponding to a discharge curve representing current discharge over time,
identify a relative state of charge from the discharge curve based on usage of the surgical instrument during a surgical procedure, and
provide the identified relative state of charge as an output.

US Pat. No. 11,026,760

DEVICES AND MOBILITY ASSISTANCE AND INFUSION MANAGEMENT

Firefly Medical, Inc., F...

1. A mobility assistance device comprising:a mast that is a central pole angled with respect to horizontal;
a first base leg connected to the mast;
a second base leg connected to the mast;
wherein the first and second base legs form an open two-sided base footprint having a triangle or truncated triangle footprint; wherein the mast and the base footprint form a mast angle having an acute angle so that the mast extends within a region that vertically extends from the two-sided base footprint;
a first wheel connected to the first base leg;
a second wheel connected to the second base leg;
a third wheel connected to a vertex region, wherein the vertex region is formed by one end of each of the first and second base legs connected to a bottom end of the mast;
a mobility handle connected to the mast;
an oxygen tank holder comprising:
an upper tank holder connected to the mast for coupling with an upper portion of an oxygen tank;
a lower tank holder connected to the first or the second base leg for coupling with a base portion of the oxygen tank wherein the lower tank holder is configured to position the oxygen tank on the first base leg or on the second base leg;
a pole connected to the mast for securing a medical component, the mast having a top end and an outer surface extending between the top end and the bottom end, wherein the pole has a longitudinal axis that is separated from the outer surface of the mast by a separation distance and is connected to the mast at the mast top end and the mast bottom end;
an outlet strip mount for securing an outlet strip;
a power cord management system comprising a first cord management bracket and a second cord management bracket connected to the mobility assistance device for storing a cord of the outlet strip; and
wherein the outlet strip mount is connected to the pole; and the power cord management system is connected to the mast.

US Pat. No. 11,026,759

SPLAYED CABLE GUIDE FOR A MEDICAL INSTRUMENT

Intuitive Surgical Operat...

1. A medical device, comprising:an instrument shaft, a housing coupled to the instrument shaft, a cable guide, a first cable, and a second cable;
the instrument shaft comprising a shaft passageway and a shaft center line;
the cable guide comprising a first guide surface, a second guide surface, one or more protrusions, and an opening;
the one or more protrusions being engaged with the housing to align the opening of the cable guide with the shaft passageway;
the first guide surface comprising a first bend portion transitioning into the opening, and the first bend portion being at a first position with reference to the shaft center line;
the second guide surface comprising a second bend portion transitioning into the opening, the second bend portion being at a second position with reference to the shaft center line, and the second position being different than the first position;
the first cable being routed along the first guide surface, around the first bend portion, through the opening, and into the shaft passageway; and
the second cable being routed along the second guide surface, around the second bend portion, through the opening, and into the shaft passageway.

US Pat. No. 11,026,758

MEDICAL ROBOTICS SYSTEMS IMPLEMENTING AXIS CONSTRAINTS DURING ACTUATION OF ONE OR MORE MOTORIZED JOINTS

Auris Health, Inc., Redw...

1. A robotic system comprising:a first robotic arm and a second robotic arm configured to control movement of a medical instrument with respect to at least first, second, and third axes, the first robotic arm comprising a first instrument driver and the second robotic arm comprising a second instrument driver, the first robotic arm comprising a plurality of linkages serially coupling a plurality of motorized joints, the plurality of motorized joints including:
a first motorized joint configured to actuate the movement of the medical instrument about the first axis,
a second motorized joint configured to linearly translate the medical instrument along the second axis, and
a plurality of additional motorized joints positioned serially between the first and second motorized joints, the plurality of additional motorized joints configured to actuate the movement of the medical instrument about the third axis;
at least one computer-readable memory having stored thereon executable instructions for operating the robotic system; and
at least one processor in communication with the at least one computer-readable memory and configured to execute the instructions to cause the system to operate in:
a first mode when the medical instrument comprises a rigid instrument, wherein operating in the first mode comprises (i) commanding the first robotic arm to control the movement of the rigid instrument in a manner that fixes a location of a remote center such that the second axis of the rigid instrument is aligned with an opening of a patient, and (ii) applying a first constraint to the motion of the plurality of motorized joints such that the second axis of the rigid instrument passes through the remote center, and
a second mode when the medical instrument comprises a flexible instrument, wherein operating in the second mode comprises (i) commanding the first robotic arm and the second robotic arm to control movement of the flexible instrument along a virtual rail such that the second axis of the flexible instrument is co-axial with the virtual rail, (ii) removing the first constraint from the motion of the plurality of motorized joints such that the second axis of the flexible instrument is not constrained to pass through the remote center, and (iii) applying a second constraint to the motion of the first robotic arm and the second robotic arm such that the first instrument driver and the second instrument driver are co-axial with the virtual rail.

US Pat. No. 11,026,757

SURGICAL CANNULAS, AND RELATED SYSTEMS AND METHODS

Intuitive Surgical Operat...

1. A surgical cannula, comprising:a bowl portion comprising an opening to permit removable insertion of a medical instrument into the bowl portion;
a tube portion extending distally from the bowl portion and configured to removably receive and permit advancement of a medical instrument inserted through the bowl portion;
an electrical connector interface at the bowl portion and configured to removably engage with an electrical connector electrically coupled to a patient return electrode, a state of engagement of the electrical connector interface being either an engaged state, in which the electrical connector interface is engaged with the electrical connector, or a disengaged state, in which the electrical connector interface is removed from engagement with the electrical connector; and
an electrical connector sensing device configured to sense whether the electrical connector interface is in the engaged state or in the disengaged state,
wherein the electrical connector sensing device is coupled to the bowl portion and is movable relative to the bowl portion between a first physical configuration and a second physical configuration;
the electrical connector sensing device is in the first physical configuration in the engaged state of the electrical connector interface; and
the electrical connector sensing device is in the second physical configuration in the disengaged state of the electrical connector interface.

US Pat. No. 11,026,756

SURGICAL ROBOT PLATFORM

Globus Medical, Inc., Au...

1. A surgical robot system comprising:a robot base including a display, the display mechanically coupled directly to the robot base;
a robot arm coupled to the robot base, wherein movement of the robot arm is electronically controlled by the robot base;
an end-effector, coupled to the robot arm, wherein the end-effector includes a guide tube configured to receive a surgical instrument; and
a force sensor configured to determine a force applied to the surgical instrument along an orientation axis of the guide tube,
wherein the robot arm includes a plurality of tracking markers configured to track the movement of the robot arm,
wherein at least one tracking marker is mounted and secured to the end-effector, and
wherein the robot arm is not moveable in six degrees of motion.

US Pat. No. 11,026,755

SYSTEMS AND METHODS FOR OPERATING AN END EFFECTOR

INTUITIVE SURGICAL OPERAT...

1. A device comprising:an end effector comprising:
a first jaw;
a second jaw;
a first actuation mechanism configured to actuate the first jaw and the second jaw toward each other with a first force; and
a second actuation mechanism configured to actuate the first jaw and the second jaw toward each other with a second force greater than the first force, the second actuation mechanism being different from the first actuation mechanism; and
a processor configured to:
actuate, using the first actuation mechanism, the first jaw and the second jaw to grasp a material at the first force;
measure a separation between the first jaw and the second jaw while grasping the material with the first force; and
determine, based on the measured separation, a prediction of success or failure in clamping the material at the second force using the second actuation mechanism.

US Pat. No. 11,026,754

MOTION EXECUTION OF A ROBOTIC SYSTEM

Verily Life Sciences LLC,...

1. A non-transitory machine readable storage medium storing logic, which when executed by a processing apparatus, causes the processing apparatus to perform operations including:receiving a signal from a controller of a surgical robot;
moving, with the surgical robot and in response to the signal, a surgical instrument through a first tissue along a trajectory that passes through the first tissue and a second tissue that differs from the first tissue; and
adjusting, based upon a difference between an actual position and a desired position of the surgical instrument, the actual position of the surgical instrument to the desired position by moving the surgical instrument through the second tissue using the surgical robot, wherein adjusting comprises using a machine learning algorithm to instruct the surgical robot to apply to the surgical instrument at least a force that is sufficient to move the surgical instrument through the second tissue, wherein the machine learning algorithm recognizes a composition of the second tissue based upon the force that is sufficient to move the surgical instrument through the second tissue.

US Pat. No. 11,026,753

SYSTEM AND METHOD FOR AUTOMATIC MUSCLE MOVEMENT DETECTION

SYNAPTIVE MEDICAL INC., ...

1. A medical navigation system for automatically detecting movement of a subject, comprising:an optical tracking system comprising an optical tracking device, the optical tracking device comprising a camera, the camera configured to couple with an end effector of a plurality of distinct end effectors;
an intelligent positioning system automatically adjusting position of the camera, the intelligent positioning system comprising an automated arm, a lifting column, and the plurality of distinct end effectors, the automated arm comprising a distal end adapted to couple with the plurality of distinct end effectors in one of switching among, independently using, and collectively using a plurality of distinct imaging instruments, the plurality of imaging instruments comprising the camera, the camera monitoring at least one muscle of the subject throughout a medical procedure, the at least one muscle comprising at least one appropriate muscle related to the medical procedure, and the position of the camera automatically adjusted to perform one of: maintain the at least one appropriate muscle within a field of view of the camera and focus on at least one different muscle when so directed;
a display; and
a controller electrically coupled with the optical tracking system and the display, the controller comprising a processor coupled with a memory, the controller configured to:
receive a data signal from the optical tracking system;
recognize and continuously monitor a plurality of optical tracking markers disposed in relation to the subject within the field of view of the camera;
provide an alert on the display when movement of the optical tracking markers disposed in relation the subject falls within predefined parameters, the predefined parameters indicative of a patient event signifying a physiological state of the subject that is of concern; and
at least one of: differentiate a muscle movement comprising a twitch from other muscle movement by determining whether at least one of a frequency and a magnitude of the muscle movement respectively exceeds at least one of a frequency threshold and a magnitude threshold of the other muscle movement, use machine learning and facial analysis software, the facial analysis software comprising an object and facial recognition engine, and use constructive feedforward neural networks for facial expression recognition,
wherein the intelligent positioning system, the optical tracking device, the automated arm, and the optical tracking markers form a feedback loop, and
wherein the feedback loop maintains a distal end of a port in constant view and in focus in relation to the end effector.

US Pat. No. 11,026,752

SYSTEM AND METHOD FOR PERFORMING AND EVALUATING A PROCEDURE

Medtronic Navigation, Inc...

1. A method of performing a procedure on a subject, comprising:determining a working volume in which a working end of an instrument is to operate;
saving the determined working volume; and
operating a navigation system to:
track a position of the working end;
determine the position of the working end relative to an edge of the working volume; and
output a representation to a user of the determined position of the working end relative to the edge of the working volume including at least one of a “planned working position” or a “not planned working position”;
wherein the representation to the user is operable to change based on the determined position of the working end relative to at least one of a “planned working position” or a “not planned working position”;
wherein the representation includes a first representation and a second representation;
wherein the first representation and the second representation are at a single indication position on a display device;
wherein the single indication position includes at least one of a horizontal bar or a vertical bar;
wherein the second representation includes the bar of a greater length than the first representation.

US Pat. No. 11,026,751

DISPLAY OF ALIGNMENT OF STAPLE CARTRIDGE TO PRIOR LINEAR STAPLE LINE

Cilag GmbH International,...

1. A surgical hub, comprising:a processor; and
a memory coupled to the processor, the memory storing instructions executable by the processor to:
receive image data from an image sensor;
generate a first image based on the image data, wherein the first image comprises a target on a first side of a tissue;
display the first image on a surgical hub display coupled to the processor;
receive a signal from a non-contact sensor, the signal indicative of a position of a surgical device on a second side of the tissue, wherein the second side is opposite of the first side;
generate a second image based on the signal indicative of the position of the surgical device on the second side of the tissue; and
display a position of the second image relative to the first image on the surgical hub display coupled to the processor.

US Pat. No. 11,026,750

REAL-TIME SURGICAL NAVIGATION

Kingston Health Sciences ...

1. A surgical navigation method, comprising:disposing one or more electromagnetic (EM) tracked localization devices in a tissue volume;
generating images of the tissue volume in real time using an EM tracked imaging device, wherein the images of the tissue volume are only generated intraoperatively;
using only data points in the images of the tissue volume to intraoperatively delineate a portion of the tissue volume at its current location;
disposing an EM tracked surgical tool in the tissue volume;
using EM tracking of the one or more localization devices, the imaging device, and the surgical tool to three-dimensionally visualize and register the surgical tool relative to the intraoperatively delineated portion of the tissue volume in real time; and
providing feedback about the location of the surgical tool relative to the intraoperatively delineated portion of the tissue volume.

US Pat. No. 11,026,749

COMPUTATIONAL SIMULATION PLATFORM FOR PLANNING OF INTERVENTIONAL PROCEDURES

Board of Regents of the U...

1. A computational simulation platform for interventional procedures planning, comprising a computer-implemented method that includes:generating a three-dimensional (3D) reconstruction of a vessel lumen and a surface of the vessel lumen based on invasive or non-invasive imaging;
generating a mesh of the 3D reconstructed vessel lumen and surface of the vessel lumen;
assigning material properties to the 3D reconstructed surface of the vessel lumen based on the invasive or non-invasive imaging, wherein the assigning of the material properties to the 3D reconstructed surface of the vessel lumen based on the invasive or non-invasive imaging includes: determining wall or plaque thickness, lumen area, plaque eccentricity and plaque constituents based on the invasive or non-invasive imaging; dividing the vessel lumen into sequential zones of plaque material; and assigning a quarter number ranging from purely calcium plaque material to purely lipid plaque material;
importing design and material properties of stents and balloons;
generating a mesh of a stent and balloon;
positioning the meshed stent and balloon within the mesh of the 3D reconstructed vessel lumen and surface of the vessel lumen, wherein the meshed stent and balloon in their crimped state are computationally positioned and bent in the mesh of the 3D reconstructed vessel lumen and surface of the vessel lumen;
performing balloon pre-dilation, stenting and balloon post-dilation computational simulations with the mesh of the 3D reconstructed vessel lumen and surface of the vessel lumen; and
assessing stent and vessel morphometric and biomechanical measures based on the computational simulations.

US Pat. No. 11,026,748

ROBOTIC SYSTEM CONFIGURED FOR NAVIGATION PATH TRACING

Auris Health, Inc., Redw...

25. A method of determining a navigation path of an instrument within a luminal network, the method comprising:displaying, on a user interface, a preoperative model corresponding to a mapped portion of a luminal network;
determining a position of a distal end of an instrument within the luminal network relative to the mapped portion of the luminal network;
moving the instrument within the luminal network;
determining that the position of the distal end of the instrument is within a predetermined distance of a boundary corresponding to a transition from an end of the mapped portion of the preoperative model to a portion of the luminal network that is unmapped in the preoperative model prior to the distal end of the instrument reaching the boundary;
entering a path tracing mode in response to determining that the position of the distal end of the instrument is within the predetermined distance of the boundary prior to the distal end of the instrument reaching the boundary; and
when in the path tracing mode, displaying visual indicia of a path traversed by the distal end of the instrument in the portion of the luminal network that is unmapped in the preoperative model relative to the preoperative model of the mapped portion of the luminal network as the instrument is navigated through the luminal network.

US Pat. No. 11,026,747

ENDOSCOPIC VIEW OF INVASIVE PROCEDURES IN NARROW PASSAGES

Biosense Webster (Israel)...

1. A method for visualization, comprising:registering, within a common frame of reference, a position sensing system and a three-dimensional (3D) computerized tomography (CT) image of at least a part of a body of a patient;
specifying, via user input, a performance characteristic, location, and orientation of at least one virtual camera within the common frame of references, wherein specifying the performance characteristic comprises instructing a processor to enable the at least one virtual camera to begin to render and display a virtual endoscopic image only when the medical tool approaches the specified location;
tracking coordinates of a medical tool moving within a passage in the body using the position sensing system; and
rendering and displaying the virtual endoscopic image, based on the 3D CT image, of the passage in the body from the specified location and orientation including an animated representation of the medical tool positioned in the virtual endoscopic image in accordance with the tracked coordinates.

US Pat. No. 11,026,746

DEVICES FOR THERAPEUTIC NASAL NEUROMODULATION AND ASSOCIATED METHODS AND SYSTEMS

National University of Ir...

1. A system for therapeutic neuromodulation in a nasal region of a human patient, the system comprising:a shaft having a proximal portion and a distal portion;
a therapeutic assembly at the distal portion of the shaft, wherein the therapeutic assembly comprises a plurality of struts, at least some of the struts comprising one or more electrodes configured to directly contact tissue, wherein the one or more electrodes are individually activatable; and
a controller operably coupled to the therapeutic assembly, wherein the controller is configured to selectively activate the electrodes of the therapeutic assembly by:
detecting a target location of postganglionic parasympathetic nerves innervating nasal mucosa and/or submucosa, inferior to a sphenopalatine foramen and/or at microforamina of a palatine bone of the human patient, based on measured bioelectric properties of a target tissue at a target site,
selecting two or more electrodes having a spacing therebetween configured to deliver neuromodulation energy at the target location of the postganglionic parasympathetic nerves,
activating the two or more electrodes while the two or more electrodes are in direct contact with the target tissue to deliver the neuromodulation energy at the target location; and
maintaining electrodes that are not proximate to the target tissue in an inactive state to avoid applying energy to non-target tissue.

US Pat. No. 11,026,745

OPEN-IRRIGATED ABLATION CATHETER WITH PROXIMAL INSERT COOLING

Boston Scientific Scimed ...

1. An open-irrigated ablation catheter system, comprising:a catheter body;
an electrode tip body mounted on a distal portion of the catheter body, the electrode tip body including a distal end and a proximal end, the proximal end configured for connection to the catheter body, the electrode tip body further including a central longitudinal axis and a wall defining an open interior region, the wall including one or more irrigation ports in fluid communication with the open interior region,
wherein the wall is conductive for delivering radio frequency (RF) energy; and
a proximal insert positioned partially within the catheter body and at least partially within the proximal end of the electrode tip body,
wherein the proximal insert includes a fluid inlet for receiving a cooling fluid delivered via the catheter body, and an exterior surface along an entire longitudinal length of the proximal insert, and
wherein the external surface of the proximal insert and an interior surface of the proximal end of the electrode tip body form an annular gap extending the entire longitudinal length of the proximal insert, the annular gap defining a flow path configured to direct the cooling fluid from the fluid inlet to cool the distal portion of the catheter body and to cool a junction of the catheter body and the electrode tip body.

US Pat. No. 11,026,744

TUMOR ABLATION DEVICES AND RELATED METHODS

DFine, Inc., South Jorda...

1. A medical device for spinal tumor ablation, the medical device comprising:a first tubular conductor;
a tubular insulator extending through the first tubular conductor such that a proximal end of the tubular insulator is proximal of the first tubular conductor and a distal end of the tubular insulator is distal of the first tubular conductor;
a second tubular conductor extending through the tubular insulator such that a distal portion of the second tubular conductor is disposed distal of the insulator, wherein at least a portion of the second tubular conductor is fixedly disposed relative to the first tubular conductor; and
an articulating distal portion of the medical device that is configured to transition from a linear configuration to a non-linear configuration;
wherein the medical device is configured such that, when the medical device is activated for ablation within a vertebra of a patient, an electrical current flows between the distal portion of the second tubular conductor and the first tubular conductor via tissue within the vertebra of the patient; and
an outer sleeve fixedly coupled to the distal portion of the second tubular conductor and distally offset from the first tubular conductor.