US Pat. No. 10,363,249

FATTY ACID SYNTHASE INHIBITOR FOR USE IN THE TREATMENT OF DRUG RESISTANT CANCER

3-V Biosciences, Inc., S...

1. A method of treating a taxane-resistant tumor or cancer in a subject, the method comprising administering to the subject in need thereof a therapeutically effective amount of:(i) a fatty acid synthase inhibitor having the structure of:

 and
(ii) a taxane.

US Pat. No. 10,363,248

SALTS OF HETEROCYCLIC MODULATORS OF HIF ACTIVITY FOR TREATMENT OF DISEASE

Board of Regents, The Uni...

1. A method of treatment of cancer comprising administering to a patient with cancer a therapeutically effective amount of a compound of structural Formula III:
wherein:
M is selected from the group consisting of an inorganic acid, an organic acid, an amino acid;
with the proviso that M is not trifluoroacetic acid;
a is a fractional or whole number between about 0.5 and about 3.5 inclusive;
b is a fractional or whole number between about 0 and about 10 inclusive;
X2 and X4 are N and X5 is O; X4 and X5 are N and X2 is O; X2 and X5 are N and X4 is O; X2 is CH, X4 is N, and X5 is O; or X2 is CH, X4 is O, and X5 is N;
Z2 is selected from the group consisting of N and CR14;
R1 is selected from the group consisting of heterocycloalkyl, alkoxyalkoxy, alkylsulfonylalkoxy, heterocycloalkyloxy, heterocycloalkylcarbonyl, alkoxyalkylamido, heterocycloalkylsulfonyl, alkoxyalkylsulfonamido, wherein said heterocycloalkyl, heterocycloalkyloxy, heterocycloalkylcarbonyl, and heterocycloalkylsulfonyl can be optionally substituted with one or more substituents selected from the group consisting hydrogen, alkyl, and oxo;
R14, R39, and R40 are independently selected from the group consisting of hydrogen, deuterium, halogen, alkyl, haloalkyl, perhaloalkyl, cyano, hydroxy, alkoxy, haloalkoxy, perhaloalkoxy, alkylthio, amino, and saturated 3- to 7-membered cycloalkyl, any of which may be optionally substituted; andR18 is selected from the group consisting of alkyl, haloalkyl, perhaloalkyl, alkoxy, haloalkoxy, perhaloalkoxy, alkylthio, haloalkylthio, and perhaloalkylthio.

US Pat. No. 10,363,247

(S,E)-3-(6-AMINOPYRIDIN-3-YL)-N-((5-(4-(3-FLUORO-3-METHYLPYRROLIDINE-1-CARBONYL)PHENYL-7-(4-FLUOROPHENYL)BENZOFURAN-2-YL)METHYL)ACRYLAMIDE FOR THE TREATMENT OF CANCER

Karyopharm Therapeutics I...

1. A compound represented by Structural Formula Ia:or a pharmaceutically acceptable salt thereof.

US Pat. No. 10,363,243

COMPOUNDS AND METHODS FOR TREATING INFLUENZA

Romark Laboratories L.C.,...

1. A method of treating a patient suffering from an influenza-like illness comprising administering to the patient a therapeutically effective amount of a compound of formula I
or a pharmaceutically acceptable salt thereof, wherein at least one of R1, R2, and R3 is OH or an ester thereof; R4, R5, and the remainder of R1, R2, and R3, are H; and R6 is NO2 and R9 is H,
wherein the influenza-like illness comprises one or more respiratory symptoms selected from the group consisting of erythematous oropharynx, hypertrophic tonsils, nasal congestion, rhonchi and adenomegaly, wherein the compound of formula I is administered at a dose selected from 100 mg to 600 mg.

US Pat. No. 10,363,241

SUBSTITUTED IMIDAZOLE DERIVATIVES AND METHODS OF USE THEREOF

vTv Therapeutics LLC, Hi...

1. A compound of Formula (X)
wherein
Q1 is selected from the group consisting of —CH2OCH2CH3 and —CH2CH2CH2CH3.

US Pat. No. 10,363,240

COMPOSITIONS AND METHODS FOR TREATING ALOPECIA

DAVID WEINSTEIN CONSULTIN...

1. A composition for the treatment of alopecia comprising 0.000012% w/v of a compound of formula (II)or a pharmaceutically acceptable salt or ester thereof, 5% w/v minoxidil, 0.12% w/v cyclosporine A, 28% w/v ethanol, 47% w/v propylene glycol and 19% w/v water, wherein w/v denotes weight by volume.

US Pat. No. 10,363,239

METHOD FOR INHIBITING GROWTH OF CANCER CELLS

Pain Therapeutics, Austi...

1. A method of inhibiting the growth of cancerous cells that contain an enhanced amount of one or more of phosphorylated-mTOR, phosphorylated-Akt1, phosphorylated-ERK2 and serine2152-phosphorylated filamin A that comprises contacting said cancer cells with an FLNA-binding effective amount of a compound or a pharmaceutically acceptable salt thereof that binds to the pentapeptide of FLNA of SEQ ID NO: 1 and exhibits at least about 60 percent of the FITC-labeled naloxone binding amount when present at a 10 ?M concentration, using unlabeled naloxone as the control inhibitor at the same concentration as said compound or salt, said pentapeptide of FLNA being biotinylated at its N-terminal valine residue and bound to a streptavidin-coated solid support, wherein said enhanced amount of phosphorylated-mTOR, phosphorylated-Akt1, phosphorylated-ERK2 and serine2152-phosphorylated filamin A being an amount that is greater by more than 1 standard deviation to three standard deviations than the amount present in a non-cancerous cell of the same type, wherein said compound is a compound of Series C-1 that corresponds in structure to Formula I below:whereinX and Y are the same or different and are SO2, C(O), CH2, CD2 (where D is deuterium), NHC(NH), OC(O), NHC(S) or NHC(O);
W is NR7, CH2, S or O, where R7 is H, C1-C12 hydrocarbyl, or C1-C12 hydrocarboyl (acyl);
Q is CHR9 or C(O);
Z is CHR10 or C(O);
J and F are the same or different and are CH or CD (where D is deuterium);
each of m, n and p is zero or one and the sum of m+n+p is 2 or 3; and
circles A and B are the same or different aromatic or heteroaromatic ring systems that contain one ring or two fused rings;
R1 and R2 are the same or different and each can be hydrogen or represent up to three substituents other than hydrogen that themselves can be the same or different (R1a, R1b, and R1c, and R2a, R2b, and R2c) each of those six groups, R1a-c and R2a-c, is separately selected from the group consisting of H, C1-C6 hydrocarbyl, C1-C6 hydrocarbyloxy, trifluoromethyl, trifluoromethoxy, C1-C7 hydrocarboyl, hydroxy-, trifluoromethyl- or halogen-substituted C1-C7 hydrocarboyl, C1-C6 hydrocarbylsulfonyl, halogen, nitro, phenyl, cyano, carboxyl, C1-C7 hydrocarbyl carboxylate, carboxamide or sulfonamide
wherein the amido nitrogen of either group has the formula NR3R4 wherein R3 and R4 are the same or different and are H, C1-C4 hydrocarbyl, or R3 and R4 together with the depicted nitrogen form a 5-7-membered ring that optionally contains 1 or 2 additional hetero atoms that independently are nitrogen, oxygen or sulfur,MAr, where M is where M is —CH2—, —O— or —N?N— and Ar is a single-ringed aryl group, and NR5R6 wherein R5 and R6 are the same or different and are H, C1-C4 hydrocarbyl, C1-C4 acyl, C1-C4 hydrocarbylsulfonyl, or R5 and R6 together with the depicted nitrogen form a 5-7-membered ring that optionally contains 1 or 2 additional hetero atoms that independently are nitrogen, oxygen or sulfur;
R8, R9, and R10 are each H, or two of R8, R9, and R10 are H and one is a C1-C8 hydrocarbyl group that is unsubstituted or is substituted with up to three atoms that are the same or different and are oxygen or nitrogen atoms;
R11, R12, R13 and R14 are all H, or R11 and R13 are H and R12 and R14 are H or D (where D is deuterium), or one of the pair R11 and R12 or the pair R13 and R14 together with the depicted ring form a saturated or unsaturated 6-membered ring, and the other pair are each H or they are H and D.

US Pat. No. 10,363,238

METHODS AND COMPOSITIONS TO ENHANCE BONE GROWTH COMPRISING A STATIN

Warsaw Orthopedic, Inc., ...

1. A method of treating a bone defect in which the bone defect site possesses at least one cavity, the method comprising inserting an implantable medical device at, near or in the defect site, the implantable medical device comprising a biodegradable polymer and a therapeutically effective amount of a statin disposed throughout the medical device to facilitate bone growth, the statin comprising at least cerivastatin, atorvastatin, simvastatin, pravastatin, fluvastatin, lovastatin, rosuvastatin, eptastatin, pitavastatin, velostatin, fluindostatin, dalvastain, or pharmaceutically acceptable salts thereof or a combination thereof, wherein the medical device allows influx of at least progenitor, and/or bone cells at, near or in the bone defect.

US Pat. No. 10,363,237

COMPOSITIONS AND METHODS OF INHIBITING N-ACYLETHANOLAMINE-HYDROLYZING ACID AMIDASE

The Regents of the Univer...

1. A method of treating a patient in need of increased levels of palmitoylethanolamide, comprising administering a pharmaceutical composition comprising a pharmaceutically acceptable carrier and a compound according to Formula I
wherein
A is O; B is O, or NRa; R1 and R2 are independently H, halogen, or optionally substituted lower alkyl; n is 1; X is NRb or CHRb; Y is C(O), C(S), or CHRc; Z is O, S, NRd, or CHRd; V is optionally substituted lower alkyl or optionally substituted lower alkenyl; wherein W is optionally substituted aryl, optionally substituted heteroaryl, optionally substituted cycloalkyl, optionally substituted cycloheteroalkyl, or C(R3R4R5); and wherein Y and V may optionally form a 5- or 6 membered ring;
wherein Ra, Rb, Rc, and Rd are independently selected from the group consisting of H, optionally substituted lower alkyl, or optionally substituted lower thioalkyl; and
wherein R3, R4, and R5 are independently H, optionally substituted lower alkyl, optionally substituted lower aryl, optionally substituted lower cycloheteroalkyl, or optionally substituted lower heteroaryl.

US Pat. No. 10,363,231

COMPOUNDS AND METHODS OF TREATING OCULAR DISORDERS

CASE WESTERN RESERVE UNIV...

1. A method of treating an ocular disorder in a subject associated with increased all-trans-retinal in an ocular tissue, the method comprising:administering to the subject a therapeutically effective amount of a primary amine compound of formula (I):

wherein R1 is a cyclic or polycyclic ring, wherein the ring is a substituted or unsubstituted aryl, heteroaryl, cycloalkyl, or heterocyclyl; wherein the ring of R1 does not include a dimethyl substituent in the ortho position to the polyene chain;
n=1-3;
where R2, R3, R4, R5, R6, and R7, are each individually hydrogen, a substituted or unsubstituted C1-C24 alkyl, C2-C24 alkenyl, C2-C24 alkynyl, C3-C20 aryl, heteroaryl, heterocycloalkenyl containing from 5-6 ring atoms (wherein from 1-3 of the ring atoms is independently selected from N, NH, N(C1-C6 alkyl), NC(O)(C1-C6 alkyl), O, and S), C6-C24 alkaryl, C6-C24 aralkyl, halo, —Si(C1-C3 alkyl)3, hydroxyl, sulfhydryl, C1-C24 alkoxy, C2-C24 alkenyloxy, C2-C24 alkynyloxy, C5-C20 aryloxy, acyl, acyloxy, C2-C24 alkoxycarbonyl, C6-C20 aryloxycarbonyl, C2-C24 alkylcarbonato, C6-C20 arylcarbonato, carboxy, carboxylato, carbamoyl, C1-C24 alkyl-carbamoyl, arylcarbamoyl, thiocarbamoyl, carbamido, cyano, isocyano, cyanato, isocyanato, isothiocyanato, azido, formyl, thioformyl, amino, C1-C24 alkyl amino, C5-C20 aryl amino, C2-C24 alkylamido, C6-C20 arylamido, imino, alkylimino, arylimino, nitro, nitroso, sulfo, sulfonato, C1-C24 alkylsulfanyl, arylsulfanyl, C1-C24 alkylsulfinyl, C5-C20 arylsulfinyl, C1-C24 alkylsulfonyl, C5-C20 arylsulfonyl, phosphono, phosphonato, phosphinato, phospho, or phosphino or combinations thereof,
wherein, R2 and R4 may be linked to form a cyclic or polycyclic ring, wherein the ring is a substituted or unsubstituted aryl, heteroaryl, cycloalkyl, or heterocyclyl; and pharmaceutically acceptable salts thereof.

US Pat. No. 10,363,230

6-SHOGAOL DERIVATIVES AND ACTIVITIES THEREOF

North Carolina Agricultur...

1. A compound having a structure of the formula:
wherein:
m is an integer between 0 and 4;
R1 is —H, halogen, halogen-substituted C1-C4 alkoxy, —COOH, or halogen-substituted C1-C4 alkyl;
R2 is —H, halogen, —OH, halogen-substituted C1-C4 alkoxy, —COOH, or halogen-substituted C1-C4 alkyl; and
R3 and R4 are independently selected from the group consisting of —H, —OH, amino, C1-C4 alkyl, C1-C4 alkylamino, and C1-C4 alkoxy, subject to the proviso that (a) when R1 and R2 are each H, (i) R3 is selected from hydroxyl and C1-C4 alkoxy and R4 is selected from OH and C2-C4 alkoxy or (ii) R3 is C1-C4 alkoxy and R4 is selected from —OH and C1-C4 alkoxy; and (b) when R4 is —H, R3 is —H, R2 is —CF3, and R1 is —F;
or a pharmaceutically acceptable salt thereof.

US Pat. No. 10,363,228

TRANSDERMAL ADMINISTRATION OF MEMANTINE

LTS Lohmann Therapie-Syst...

1. Transdermal therapeutic systems comprising memantine as an active ingredient, said memantine present as a free base or as a physiologically compatible salt or prodrug,said transdermal therapeutic systems including at least one transdermal therapeutic system comprising
a backing layer impermeable to active ingredient;
a fabric or paper stabilizer;
at least one active-ingredient-containing layer having an area concentration of memantine of at least 15 mg/cm2 to 70 mg/cm2 and which further comprises a storage material into which the active ingredient is introduced;
a tmax of 30 h to 48 h;
and wherein either consecutive or staggered administration of one or more of the transdermal therapeutic system at a time for administration intervals each lasting 12 h to 168 h independently of one another, for achieving active ingredient concentrations in a blood plasma of an individual requiring treatment, achieves, in the blood plasma, active ingredient concentrations from a beginning of the administration of a first of one or more of said transdermal therapeutic system as follows:
after 24 h, at least 14 ng/ml to no more than 50 ng/ml,
after 48 h, at least 27 ng/ml to no more than 90 ng/ml,
after 60 h, at least 32 ng/ml to no more than 110 ng/ml,
after 72 h, at least 37 ng/ml to no more than 130 ng/ml,
after 96 h, at least 44 ng/ml to no more than 150 ng/ml,
after 144 h, at least 54 ng/ml to no more than 180 ng/ml,
after 192 h, at least 60 ng/ml to no more than 195 ng/ml,
after 240 h, at least 63 ng/ml to no more than 200 ng/ml, and
after 300 h, at least 65 ng/ml to no more than 210 ng/ml,
and said transdermal therapeutic systems have a memantine pharmacokinetic delay, tlag, of not more than 6 hours.

US Pat. No. 10,363,227

PHARMACEUTICAL FORMULATION FOR USE IN THE TREATMENT AND/OR PREVENTION OF RESTENOSIS

Centre Hospitalier Univer...

1. A method of treatment of restenosis after open surgical revascularization in a subject in need thereof, said method comprising administering by the perivascular route a pharmaceutical formulation consisting in a gel phase comprisingi) at least one rapidly delivered compound effective on the acute inflammatory phase of the early stage of restenosis development comprising a statin, and
ii) a sustained release formulation comprising a statin effective on later phases of restenosis development, wherein the sustained release formulation is in the form of microspheres or nanospheres.

US Pat. No. 10,363,226

PLATELET MEMBRANE-COATED DRUG DELIVERY SYSTEM

North Carolina State Univ...

1. A platelet membrane-coated nanovehicle, comprisinga) an inner core comprising a drug delivery matrix, wherein the drug delivery matrix comprises an antineoplastic therapeutic agent; and
b) an outer shell platelet membrane coating the inner core, wherein the outer shell platelet membrane further comprises tumor necrosis factor (TNF)-related apoptosis inducing ligand (TRAIL) and endogenous P-selectin protein.

US Pat. No. 10,363,222

MULTIPLE UNIT DOSAGE FORM HAVING A THERAPEUTIC AGENT IN COMBINATION WITH A NUTRITIONAL SUPPLEMENT

JDS Therapeutics, LLC, P...

1. A dosage form for oral administration comprising:an inner therapeutic agent core comprising a therapeutic agent, wherein the therapeutic agent core is located at the center of the dosage form;
a middle barrier layer disposed directly on and surrounding the inner therapeutic agent core; and
an outer nutritional supplement layer disposed directly on and surrounding the middle barrier layer consisting of a nutritional supplement and one or more additional components selected from the group consisting of a pharmaceutically acceptable carrier, a sweetener, a flavoring agent, a coloring agent, a preservative and an excipient, and wherein the nutritional supplement is selected from the group consisting of biotin, choline, folate, niacin, pantothenic acid, riboflavin, thiamine, vitamin A, vitamin B6, vitamin B12, vitamin C, vitamin E, bromine, cobalt, copper, fluorine, germanium, iodine, iron, magnesium, manganese, molybdenum, potassium, selenium, silicon, zinc, calcium, phosphorous, sodium, sulfur, and vanadium, or combinations thereof.

US Pat. No. 10,363,220

COMPARTMENTED PHARMACEUTICAL DOSAGE FORMS

Triastek, Inc., Nanjing ...

1. A dosage form comprising:a single substrate having a top and a bottom that forms at least a first compartment and a second compartment, wherein the first compartment has a first top and a first bottom, wherein the second compartment has a second top and a second bottom, wherein the first top and the second top are positioned at the top of the single substrate, wherein the first bottom and the second bottom are positioned at the bottom of the single substrate;
wherein the first compartment has a first aperture of a first pre-defined shape and the second compartment has a second aperture of a second pre-defined shape;
a first drug loaded into the first compartment such that the first drug is linked to the internal wall of the first compartment;
a second drug loaded into the second compartment such that the second drug is either linked to the internal wall of the second compartment or freely moving within the second compartment,
wherein each of the first compartment and the second compartment comprises a void space that provides a floating effect to the dosage form;
a first plug that seals the first aperture; and
a second plug that seals the second aperture,
wherein the first plug and the second plug are water soluble or erodible, and
wherein the first plug seals the first aperture at the first top, and wherein the second plug seals the second aperture at the second top.

US Pat. No. 10,363,216

FOAMABLE VEHICLES AND PHARMACEUTICAL COMPOSITIONS COMPRISING APROTIC POLAR SOLVENTS AND USES THEREOF

Foamix Pharmaceuticals Lt...

1. A method of treating a skin, mucosal, or body cavity disorder comprising administering to skin, mucosal, or body cavity a composition comprising:a) about 1% to about 5% of a minocycline;
b) one or more short chain alcohols comprising ethanol;
c) about 2% to about 50% by weight of the composition of one or more protic polar solvents comprising propylene glycol;
d) one or more polymeric agents comprising a cellulose ether; e) one or more modulating agents comprising an antioxidizing agent;
f) a metal; and
g) an essential oil;
wherein the composition is essentially free of fatty alcohol;
wherein the composition is surfactant free; and
wherein the composition is waterless.

US Pat. No. 10,363,201

BABY BOTTLE APPARATUS WITH FLOW CONTROL

ELIEZER ELIMELECH ROSE, ...

1. A baby bottle apparatus, comprising:a nipple;
a liquid container;
a flexible tube connecting said nipple to said container;
a normally-closed valve, for controlling fluid flow from said container to said nipple;
at least one lever, for opening said valve for fluid passage from said container to said nipple, thereby allowing a user to control fluid flow from said baby bottle apparatus,
wherein said valve comprises:
two parallel bars, at least one of said parallel bars being connected to one of said at least one lever; and
at least one elastic member, for pulling or pushing one of said parallel bars toward the other, and
wherein said flexible tube is disposed between said parallel bars, thereby resulting in said normally-closed state valve.

US Pat. No. 10,363,200

TABLET SPLITTING APPARATUS

TOSHO, INC., Tokyo (JP)

1. A tablet splitting apparatus comprising:a guide having a groove passage for guiding a falling tablet;
a catcher for holding a tablet moving downward through the groove passage at a mid-portion of the groove passage; and
a splitting mechanism for splitting a tablet held by the catcher;
wherein the splitting mechanism comprises a pair of blades for splitting the tablet received by the catcher, and a pair of blade shifters that allow the blades to be attached thereto at predetermined positions,
a housing is further provided in which the guide, the catcher, and the splitting mechanism are accommodated,
the housing comprises an opening allowing the guide and the blades to move therethrough, and a support detachably fixing the guide at a supporting position in the housing,
the support and the guide each comprise a sliding portion for fixing the guide, and the support and the guide are in a slidable contact with each other at the sliding portions while the guide is supported at the supporting position,
the guide disposed at the supporting position is slid along the sliding portion of the support so as to be detachable from the supporting position through the opening,
the blades and the blade shifters each comprise a sliding portion at which each of the blades is attached to a corresponding one of the blade shifters or at which each of the blade shifters allows a corresponding one of the blades to be attached thereto, and the blades and the blade shifters are in a slidable contact with each other at the sliding portions for attaching the blades while the blades are attached to the respective predetermined positions, and
the blades attached to the respective predetermined positions of the blade shifters are slid along the sliding portions of the blade shifters so as to be detachable from the blade shifters through the opening.

US Pat. No. 10,363,199

SYRINGE ADAPTER

1. A syringe adapter for connecting a dosing syringe to a container for taking up a fluid comprising:a fluid delivery channel for creating a flow connection between the inside of the container and the inside of the dosing syringe,
at least one ventilation channel for creating an air connection between the inside of the container and the container surroundings,
wherein in at least one of the channels a non-return valve is arranged which in an open position enables the passage of media and in a closed position closes the channel,
wherein a main adapter body on the one hand and the at least one non-return valve on the other hand are made at least partly from different plastic materials,
wherein the at least one non-return valve comprises an anti-drip valve which is arranged in the fluid delivery channel, which opens with the application of negative pressure to a syringe-side end of the fluid delivery channel, and which otherwise closes, and
further comprising at least one additional non-return valve which comprises a normally closed ventilation valve which is arranged in the ventilation channel, and which opens with the application of negative pressure to a container-side end of the ventilation channel
wherein the anti-drip valve comprises a duckbill valve.

US Pat. No. 10,363,198

HAND-PRESSING HEADACHE-RELIEVING DEVICE

1. A hand-pressing headache-relieving device, comprising:a C-shaped device body having a first side and a second side arranged in a spaced-apart relationship with one another and connected to one another by a connecting portion, the C-shaped body delimiting a hand space therewithin;
a pressing element provided on the second side and protruding into the hand space of the device body, the pressing element configured to apply pressure against a pressure point on a user's hand positioned in the hand space; and
at least one strap connecting the first side and the second side of the device body on at least one side of the connecting portion.

US Pat. No. 10,363,197

SYSTEMS AND METHODS FOR PROVIDING NETWORK CONNECTIVITY AND REMOTE MONITORING, OPTIMIZATION, AND CONTROL OF POOL/SPA EQUIPMENT

Hayward Industries, Inc.,...

1. A method for remotely monitoring and controlling a pump for a pool or a spa, comprising the steps of:assigning by a processor of the pump an Internet Protocol (IP) address to the pump;
establishing a network connection between the processor of the pump and a remote device;
providing for remote monitoring of operational parameters associated with the pump from the remote device over the network connection;
providing for remote control of the pump from the remote device over the network connection;
receiving at the processor data on forecasted weather conditions based on the location of the pump; and
determining by the processor if periods of forecasted temperatures above a temperature setpoint and load conditions above a load setpoint coincide based on the forecasted weather conditions and a pump schedule received at the processor from a memory; and
controlling, by the processor, the pump based on the determination.

US Pat. No. 10,363,196

VIBRATOR APPARATUS FOR USE IN PHYSICAL TREATMENT

1. A vibrator apparatus in a vibration device for physical treatment usage comprising:a coil which is configured to rigidly attach to a member of the vibration device, the coil being configured to receive electric signals from a signal unit, and
a permanent magnet suspended by springy elements which are configured to attach to said member and is movable relative to the member,
wherein the coil and the permanent magnet are co-axially aligned, and wherein the permanent magnet is linearly and coaxially mutually movable relative to the coil between extreme positions being farthest away from the coil and between extreme positions being closest to the coil upon application of said electric signals to the coil, and
an actual distance of movement for the permanent magnet, relative to the coil, is less than axial length of the coil,
wherein the springy elements which provide tensioning and suspension of the permanent magnet relative to said member are provided by using a pair of springs located at a distance from a respective axial end portion of the permanent magnet, wherein a central part of each spring is configured to be rigidly connected to the member,
wherein from each central part there extends a spring material face which at its radially outer edge region is rigidly linked to said respective axial end portion of the permanent magnet, and
wherein the spring material face at its outer edge region is fixedly linked to the respective axial end portion of the permanent magnet at least at three locations having a space therebetween by respective spacers.

US Pat. No. 10,363,195

DEVICES AND METHODOLOGIES FOR PHYSICAL THERAPY AND WELL BEING

1. A device for physical therapy, comprising:an axis;
a plurality of balls rotatably mounted on said axis, wherein each ball is equipped with a shaft through which said axis extends, and wherein a surface of said shaft is equipped with a plurality of spaced apart protrusions; and
an adjustable locking feature disposed on said axis that rotatably and releasably engages grooves formed by spaces between said protrusions such that the length of the device in the longitudinal direction of said axis is adjustable to any of a plurality of fixed, predetermined values;wherein each ball is equipped with an annular indentation, and wherein said axis is a ball lock pin.

US Pat. No. 10,363,194

ORAL APPLIANCE FOR ADMINISTRATION OF ELECTRICAL STIMULATION AND METHOD FOR THE USE THEREOF

TRUDELL MEDICAL INTERNATI...

6. A method of administering an electrical stimulation to a posterior region of an oral cavity of a subject comprising:inserting spaced apart first and second flexible tubes into the oral cavity of the subject;
disposing output ends of the first and second spaced apart flexible tubes in first and second posterior regions of the oral cavity of the subject, wherein the first flexible tube is positioned in a first buccal region such that occlusal surfaces of the subject's teeth are not covered by the first flexible tube, and wherein the second flexible tube is positioned in a second buccal region opposite the first buccal region such that the occlusal surfaces of the subject's teeth are not covered by the second flexible tube;
supplying electrical current to electrode leads disposed within each of the first and second flexible tubes; and
applying electrical stimulation to the first and second posterior regions of the oral cavity with bipolar electrodes connected to each of the electrode leads of each of the first and second flexible tubes, respectively, wherein the bipolar electrodes are coupled to the first and second flexible tubes adjacent the output ends thereof.

US Pat. No. 10,363,193

SYSTEMS AND METHODS FOR DECOMPRESSION, ELLIPTICAL TRACTION, AND LINEAR TRACTION OF THE OCCIPUT, CERVICAL SPINE, AND THORACIC SPINE

21. A method of treating a spine, the method comprising the steps of:securing a traction device to a head of a user, the traction device comprising a support frame having a transverse neck support projecting upwardly from a base of the support frame and first, second, and third inflatable bladders coupled to the neck support, wherein securing the traction device to the head comprises positioning the traction device such that:
the first inflatable bladder transverses a cervical spine of the user;
the second inflatable bladder transverses an upper thoracic spine of the user; and
the third inflatable bladder transverses an occiput of the user;
expanding the first inflatable bladder in a direction outward from the neck support and toward and substantially normal to the cervical spine to force the cervical spine to curve forwardly;
expanding the second inflatable bladder in a direction toward the upper thoracic spine to force the thoracic spine to decompress and reduce hyper-kyphosis of the upper thoracic spine; and
expanding the third inflatable bladder in a direction toward the occiput to apply an angular traction to a cervical spine of the user;
wherein the first inflatable bladder is positioned anteriorly to the second inflatable bladder and the third inflatable bladder; and
wherein the shape of the second inflatable bladder corresponds the shape of the third inflatable bladder.

US Pat. No. 10,363,192

DEVICE AND METHOD FOR INSTILLING INTRINSIC MOTIVATION REGARDING EYE CONTACT IN CHILDREN AFFECTED BY EYE CONTACT DISORDERS

Matthew Casey, Woburn, M...

1. A therapy method for encouraging a patient diagnosed with autism, an autism spectrum disorder, and/or a neurodevelopment disorder to make eye contact with other individuals, said therapy method comprising:treating the patient by placing a robot in a field of view of the patient such that the robot can interact with the patient thereby creating intrinsic motivation in the patient to make eye contact with the other individuals after a therapy session has ended, the robot comprising:
prominently featured animatronic eyes on a front side thereof;
a video camera;
a processor configured to:
process data from the video camera to determine a gaze direction of the patient during the therapy session; and
select a gaze direction for the animatronic eyes based on the determined gaze direction of the patient; and
an actuator that allows the interaction with the patient by controlling the animatronic eyes based on the selected gaze direction for the animatronic eyes; and
refraining from providing the patient with a positive reinforcement for gazing at the animatronic eyes during the therapy session;
wherein movement of the animatronic eyes constitutes the only electronically actuated movement of the robot.

US Pat. No. 10,363,191

MULTIFUNCTIONAL CURVED BOARD

Gymba Oy, Joensuu (FI)

1. A multi-functional curved board used as a support for legs of a user and for general maintenance of muscle strength, the multi-functional curved board having one or more curved bodies comprising a radius of curvature, a longitudinal axis, and at least one raised foot support, wherein the one or more curved bodies are rigid in a direction of the radius of curvature, supporting at least a weight of the user, and flexible in a direction transverse to the radius of curvature so that the multi-functional curved board can be bent in the direction transverse to the radius of curvature to enable the multi-functional curved board to rotate around the longitudinal axis.

US Pat. No. 10,363,190

ATTACHMENT DEVICE FOR A SURGICAL LIMB SUPPORT

1. An attachment device for use with a limb support for supporting a patient's limb adjacent to a support surface of an operating table, the attachment device comprising:1) an elongate support member extending in a substantially vertical orientation, the elongate support member having a first attachment portion at an upper end thereof, the first attachment portion configured to releasably attach to a horizontal side rail of an operating table so that the elongate support member extends vertically below a support surface of the operating table; and
2) an adjustment member including:
a first portion configured to allow movable engagement of the adjustment member both rotationally and along the elongate support member; and
a second attachment portion configured to attach the limb support to the attachment device, or wherein the adjustment member is integrally formed with the limb support;
wherein the attachment device is configured to provide at least two positions of the adjustment member, including:
a use position, wherein the adjustment member is positioned at the upper end of the elongate support member, to position the limb support outwards of and adjacent to the support surface of the operating table; and
a non-use position, wherein the adjustment member is positioned distal from the upper end of the elongate support member and rotated on the elongate support member about a vertical axis such that the limb support is oriented and positioned under the support surface of the operating table.

US Pat. No. 10,363,189

SURGICAL PATIENT SUPPORT FOR ACCOMMODATING LATERAL-TO-PRONE PATIENT POSITIONING

Allen Medical Systems, In...

1. A surgical patient support, comprising:a support frame including first and second support rails extending parallel to each other from a head end to a foot end of the patient support, a head-cross beam and a foot-cross beam connected to each of the support rails at the head end and foot end respectively, and a connection arm engaged with the head-cross beam,
a platform mounted on the frame and including a torso section and a leg section, and
an actuator assembly coupled to the support frame and configured to support the leg section,
wherein the leg section is configured to move between a raised position and a lowered position,
wherein the first and second support rails each include a torso rail and a leg rail, the torso rails each extending from the head-cross beam towards the foot end to connect with the leg rail of the respective support rail, and each leg rail extends from connection with the torso rail of the respective support rail towards the foot end,
wherein each leg rail includes a first sub-rail and a second sub-rail, and each first sub-rail extends from connection with the torso rail of the respective support rail towards the foot end at an angle relative to the torso rail of the respective support rail,
wherein each second sub-rail extends from connection with the foot-cross beam for connection with the first sub-rail of the respective support rail.

US Pat. No. 10,363,188

PATIENT MANEUVERING APPARATUS

1. A patient maneuvering apparatus comprising: a substantially planar body having a perimeter, a top surface, a bottom surface opposing the top surface, a length and a width, a left end of the length, and a right end of the length; a mesh layer including a mesh layer thickness at least partially defining the bottom surface; a fabric layer of an absorbent material at least partially defining the top surface, the fabric layer including a fabric layer thickness; and a strip of continuous material defining a border, a first handle, and a second handle, the border spanning the perimeter of the body, surrounding the mesh and fabric layers, and with a border thickness greater than each of the mesh layer thickness and the fabric layer thickness; the strip of continuous material is sewn to the planar body about the perimeter and is folded and mitered at at least three points around the perimeter, and the strip of continuous material is sewn to the planar body at the points where it is folded and mitered, the first handle defining a first aperture sized and shaped to receive at least a portion of a user's hand at the left end and having a length that is longer than, and which spans, the width of the planar body, and the second handle defining a second aperture sized and shaped to receive the at least a portion of a user's hand at the right end and having a length that is longer than, and which spans, the width of the planar body.

US Pat. No. 10,363,187

METHODS AND APPARATUS FOR MOVING A PATIENT FROM A RECLINING POSITION TO AN UPRIGHT SITTING POSITION

CNS Solutions, LLC, Gree...

1. An apparatus for moving a patient between a reclining position on a bed and a generally upright sitting position, the apparatus comprising:a base;
a lifting mechanism secured to the base; and
an articulating patient support platform secured to the lifting mechanism, wherein the patient support platform is movable via the lifting mechanism between raised and lowered generally horizontal positions, wherein the patient support platform comprises:
a first panel comprising opposite first and second ends;
a second panel movably attached to the first panel first end and upwardly pivotable from a substantially co-planar relationship with the first panel to a substantially orthogonal relationship with the first panel; and
a third panel secured to the second panel in spaced-apart, substantially co-planar relationship therewith;
wherein the patient support platform is positionable on the bed such that a patient lying on the bed can be moved onto the patient support platform and positioned such that the patient's upper body is supported by the first and second panels and the patient's legs are supported by the third panel, and wherein the weight of the patient's legs on the third panel causes the third panel to move and pivot the second panel upwardly such that the patient is moved to a generally upright sitting position.

US Pat. No. 10,363,186

MODULAR, DEFORMABLE, CUSHIONED, RESISTIVE INFANT POSITIONING SYSTEM AND METHOD

1. A method of using an infant positioning system (100) to position an infant, comprising:obtaining a first tubular pillow (20) fashioned from fabric formed into a tubular shape extending from a left distal end (21) to a right distal end (29) by seaming said fabric along at least one peripheral edge to create a seamline (23) and filled with a first pre-determined amount of a manipulatable resilient cushioning material (35); said first tubular pillow (20) comprising a first pillow left chamber (22); a first pillow right chamber (28); and a first seam (25) disposed at a midpoint of said tubular shape that enables flexing of said first pillow left chamber (22) with respect to said first pillow right chamber (28) at said first seam (25);
placing the infant in a supine position;
obtaining a second tubular pillow (40) fashioned from fabric formed into a second tubular outer shell extending from a left distal end (41) to a right distal end (49) by seaming said fabric along at least one peripheral edge to create a seamline (43) and filled with a second pre-determined amount of said manipulatable resilient cushioning material (35); said second tubular pillow (40) comprising a second pillow left chamber (42); a second pillow right chamber (48); and a second seam (45) disposed at a midpoint of said tubular shape that enables flexing of said second pillow left chamber (42) with respect to said second pillow right chamber (48) at said second seam (45);
manipulating said second pre-determined amount of said manipulatable resilient cushioning material (35) within said second tubular pillow (40);
flexing said second tubular pillow (40) at said second seam (45) to form a U-shape;
positioning said second tubular pillow (40) with inward-facing portions of said second pillow left chamber (42) snuggly touching the outer left side of the infant's legs and the outer left side of the infant's trunk to create a left lower boundary;
positioning said second tubular pillow (40) with inward-facing portions of said second tubular pillow right chamber (48) snuggly touching the outer right side of the infant's legs and the outer right side of the infant's trunk to create a right lower boundary;
obtaining a compact pillow (60) filled with a third pre-determined amount of a manipulatable resilient cushioning material (35);
manipulating said third pre-determined amount of a manipulatable resilient cushioning material (35) within said compact pillow (60);
placing said compact pillow (60) adjacent the infant;
manipulating said first pre-determined amount of said manipulatable resilient cushioning material (35) within said first tubular pillow (20);
flexing said first tubular pillow (20) at said first seam (25);
positioning said first tubular pillow (20) with inward-facing portions of said first pillow left chamber (22) snuggly touching the left top of the infant's head, the left upper side of the infant's head, and the left distal end (41) of said second tubular pillow (40); and
positioning said first tubular pillow (20) with inward-facing portions of said first pillow right chamber (28) snuggly touching the right top of the infant's head, the right upper side of the infant's head, and the right distal end (49) of said second tubular pillow (40).

US Pat. No. 10,363,185

SYSTEM AND METHOD FOR OFF-LOADING OF THE BODY IN THE PRONE POSITION AND FOR PATIENT TURNING AND REPOSITIONING

1. A support system for support and off-loading of a received body part comprising:a positioner filled with a flowable composition that has no shape memory;
a first air plenum, the first air plenum consisting of a gas therein, and
a second air plenum adjacent to the first air plenum, said second air plenum consisting of a gas therein,
wherein the first and second air plenums comprise bladder portions that are of a substantially similar size and shape and are configured to be placed on top of one another in a planar relationship in use;
wherein said positioner is adapted to be received under either said first air plenum or said second air plenum, said positioner displaces said gas within said first air plenum and said second air plenum,
wherein at least one of the first air plenum or the second air plenum comprises an upper bladder and a lower bladder, wherein the lower bladder has a smaller width than the upper bladder such that it forms a tail extension portion, and
one or more handles associated with the tail extension portion, such that the tail extension portion can be folded underneath the support system.

US Pat. No. 10,363,184

PATIENT SUPPORT APPARATUS HAVING URINARY DRAINAGE BAG LOCKOUT FEATURE

Hill-Rom Services, Inc., ...

1. A patient support apparatus comprising:a frame having a first portion and a second portion, the first portion being pivotally movable to raise and lower relative to the second portion;
a drainage bag support coupled to the first portion of the frame to move therewith, the drainage bag support having a first rung that is substantially horizontal to a floor when the first portion is raised and a second rung that is angled with respect to the first rung and is substantially horizontal to the floor when the first portion is lowered;
control circuitry to control movement of the first portion of the frame, wherein the control circuitry has a lockout mode to prevent movement of the first portion of the frame relative to the second portion of the frame, and
an indicia positioned adjacent the drainage bag support notifying a caregiver to activate the lockout mode in response to a drainage bag being coupled to the first rung of the drainage bag support so that the first portion is unable to be moved to place the drainage bag in an unwanted position.

US Pat. No. 10,363,183

METHOD OF PATIENT CARE DEVICE INTEGRATION WITH A HOSPITAL BED

Hill-Rom Services, Inc., ...

1. A method comprisingcoupling a catheter monitor to a first barrier of a frame of a patient bed,
coupling a patient care device to a second barrier of the frame of the patient bed,
operating bed control circuitry of the patient bed to control at least one function of the patient bed,
operating the catheter monitor so that first circuitry of the catheter monitor communicates with the bed control circuitry, and
operating the patient care device so that second circuitry of the patient care device communicates with the bed control circuitry.

US Pat. No. 10,363,182

PATIENT CONTROL ARM WITH PHONE DOCK AND HEAD OF BED LOCKOUT

Hill-Rom Services, Inc., ...

1. A patient control unit for controlling functions of a hospital bed, the patient control unit comprising a housing having a first side that includes a plurality of user inputs to control the functions of the hospital bed, the housing having a second side having a dock to secure a handheld electronic device in place on the housing, wherein the first and second sides face in opposite directions, wherein the dock comprises a pair of clamp members that are spaced apart from one another and that are substantially similarly shaped so that the electronic device is securable to the dock in a first orientation or a second orientation, wherein the handheld electronic device is clamped at opposite sides thereof between the pair of clamp members due to a spring bias of a spring acting on a movable first clamp member of the pair of clamp members with a second clamp member of the pair of clamp members being a stationary clamp member fixed to the second side of housing, wherein the spring is located relative to the housing so that the movable first clamp member is situated between the spring and the second clamp member, and wherein when the first and second sides of the housing are generally vertically oriented, the patient control unit is devoid of any structure beneath the handheld device that engages a bottom of the handheld device when the handheld device is secured to the housing by the pair of clamp members.

US Pat. No. 10,363,181

PATIENT POSITION DETECTION FOR PATIENT SUPPORT APPARATUS

Hill-Rom Services, Inc., ...

1. A patient support apparatus comprisinga patient support structure configured to support a patient, the patient support structure having a head end and a foot end spaced apart in a longitudinal dimension of the patient support structure, the patient support structure having a head section that is configured to support a torso of a patient and that is movable between a raised position for supporting the patient in a sitting up position and a lowered position for supporting the patient in a lying down position,
a set of user inputs configured to receive input from a caregiver to initiate the movement of the head section between the raised and lowered positions,
a graphical user interface (GUI) supported by the patient support structure, and
control circuitry coupled to the GUI, the GUI being controlled by the control circuitry to display information indicating, when the patient is lying down on the patient support structure about midway between opposite sides of the patient support structure, that the patient is improperly positioned on the patient support structure in the longitudinal dimension of the patient support structure due to being shifted too far towards the head end or too far towards the foot end for the movement of the head section toward the raised position, wherein the information indicating that the patient is improperly positioned includes all three of the following: (i) a text box with a message conveying the information, (ii) a pictorial representation of a patient lying on the patient support surface too close to the at least one of the head end and foot end, and (iii) a hip position icon that is color coded.

US Pat. No. 10,363,180

SUPPORT ASSEMBLY WITH SELECTIVE ORBITAL ROTATION ABOUT BRACKET

Adaptive Engineering Lab,...

1. A support assembly for a wheelchair, the support assembly comprising:a fixable portion adapted to be fixedly mounted to the wheelchair, the fixable portion including:
at least one mount adapted to be mounted to the wheelchair; and
a shaft having a keyway formed therein, the shaft being supportable by the at least one mount; and
a rotatable portion received on the shaft of the fixable portion and being in selective locked engagement therewith, the rotatable portion including:
a bracket body defining an opening into which the shaft of the fixable portion is received; and
a key member providing a key, the key member being supported by the bracket body and movable in linear translation between an engaged position in which the key is engaged with the keyway in the shaft to lock an orientation of the bracket body of the rotatable portion relative to the shaft of the fixable portion and a disengaged position in which the key is disengaged from the keyway in the shaft to permit the rotatable portion to rotate relative to the fixable portion about an axis of rotation defined by the shaft
wherein the bracket body includes a cavity extending from one side to the other side of the bracket body in which the key member is received, the cavity of the bracket body being in communication with the opening in the bracket body in which the shaft is received such that the key of the key member is engageable with the keyway in the shaft in at least one orientation of the rotatable portion relative to the fixable portion;
wherein the rotatable portion further comprises a post connected to the key member, a biasing element that is interposed between the post and the bracket body to bias the key member to the engaged position, and a depressible button connected to the bracket body that is positioned to contact the post and, upon depression of the depressible button overcome the biasing force of the biasing element to move the key member to the disengaged position.

US Pat. No. 10,363,179

WHEELCHAIR INCLUDING ACCOMMODATION POCKET

SWANY CORPORATION, Kagaw...

1. A wheelchair comprising:driving wheels;
a pair of side frames that rotatably support the driving wheels coupled to exterior sides of the side frames, each of the side frames including
an elbow rest frame portion that has an elbow rest,
a vertical frame portion that is coupled to a rear end part of the elbow rest frame portion,
a lower frame portion that is arranged under the elbow rest frame portion, the vertical frame portion being coupled to a rear end part of the lower frame portion, and
a middle frame portion that is positioned between the elbow rest frame portion and the lower frame portion, the vertical frame portion being coupled to a rear end of the middle frame portion; and
an accommodation pocket that is arranged above the front part of one of the driving wheels as viewed in side view, and is at least partially positioned on an exterior side relative to the elbow rest frame portion as viewed in front view, and
grip rings that are arranged on exterior surfaces of the driving wheels,
wherein the whole accommodation pocket is arranged between the elbow rest frame portion and the middle frame portion, and
wherein the accommodation pocket has an exterior-side plate, which is a plate-shaped material and defines the exterior side of the accommodation pocket, and the exterior-side plate is arranged on the interior side relative to the grip ring.

US Pat. No. 10,363,178

MOTOR VEHICLE WITH A MOBILE VEHICLE SEAT

FORD MOTOR COMPANY, Dear...

1. A motor vehicle having a mobile vehicle seat, the mobile vehicle seat comprising:a frame that forms a seating surface and a backrest;
an energy source arranged in the frame;
a drive motor arranged in the frame and connected to the energy source;
a control device to control the drive motor;
a first coupling arranged on the frame that releasably fixes the frame to the motor vehicle;
a second coupling corresponding to the first coupling seating surface arranged on an inside of a vehicle door that is mounted pivotably on a vehicle superstructure, wherein the second coupling releasably engages with the first coupling of the frame of the seating surface;
two wheels arranged on an axle and in drive connection with the drive motor provided on the frame, wherein the control device is configured to dynamically balance a vehicle seat using the two wheels during driving operation.

US Pat. No. 10,363,177

FOLDING STRETCHER

FIBRELIGHT DEVELOPMENTS L...

1. A rescue device comprising:at least two collapsible columns defining a core section structured to support a subject to lie on the core section during use, with each collapsible column lying adjacent at least one other column; and
a plurality of links, wherein
each respective collapsible column of the at least two collapsible columns comprises:
a plurality of rods;
at least one connector; and
a plurality of sleeves;
wherein:
each rod is located within at least one of the respective sleeves;
the plurality of rods are connectable in series by the at least one connector to form the respective collapsible column of the at least two collapsible columns; and
each sleeve is connected to at least one other sleeve by attachment to at least one of the links, the links being arranged substantially perpendicularly to the at least two collapsible columns and being flexible, at least some of the links comprising an extension strap that extends out from a side of the core section and being attached to quick release buckles to enable the subject to be carried to be secured into the rescue device during use;
the rescue device further comprises handles to lift the rescue device, the handles formed either by ends of the links or by extension straps being secured between two of the links to form a loop configured to be grasped;
wherein the device further comprises at least one biaser attached to at least one end of the respective collapsible column and passing through a lumen of the respective collapsible column, and
wherein an end of the at least one biaser is restrained adjacent to or around a stopper, such that the stopper is prevented from being drawn into the lumen of the respective collapsible column and is structured to prevent an entirety of the at least one biaser from being drawn into the lumen of the respective collapsible column.

US Pat. No. 10,363,176

REFASTENABLE DISPOSABLE GARMENT HAVING A CURLED EDGE, AND PROCESS FOR MAKING SAME

Kimberly-Clark Worldwide,...

1. A refastenable disposable absorbent garment defining a longitudinal direction and a transverse direction, the garment defining longitudinally spaced apart first and second waist edges extending generally in the transverse direction, the garment comprising:a first waist region contiguous with the first waist edge and defining first and second side edges spaced apart in the transverse direction, the first waist region defining opposed first and second surfaces, wherein the first surface is a body-facing surface and the second surface is a garment facing surface, wherein the first waist region is elastomeric proximal both the first side edge and the second side edge of the first waist region;
a second waist region contiguous with the second waist edge and defining first and second side edges spaced apart in the transverse direction;
a crotch region that extends between and interconnects the first and second waist regions;
the garment further comprising a non-extensible, relatively rigid first fastening component comprising a mechanical fastener attached to the body-facing surface of the first waist region at a location transversely inward from its first side edge and further comprising a non-extensible, relatively rigid second fastening component comprising a mechanical fastener attached to the body-facing surface of the first waist region at a location transversely inward from its second side edge, the first and second fastening components each having a length;
wherein the first waist region defines a first flange portion located transversely outward of the first fastening component such that the first flange portion is positioned between the first side edge and the first fastening component and has a first transverse width defined as the transverse distance from an outward-most edge of the first fastening component to the first side edge and a second flange portion located transversely outward of the second fastening component such that the second flange portion is positioned between the second side edge and the second fastening component and has a second transverse width defined as the transverse distance from an outward-most edge of the second fastening component to the second side edge,
wherein the first flange portion is transversely curled toward the garment facing surface of the first waist region along a first flange portion curled length, and wherein the second flange portion is transversely curled toward the garment facing surface of the first waist region along a second flange portion curled length.

US Pat. No. 10,363,175

CARTON WITH A RECLOSABLE OPENING

1. A reclosable carton for accommodating a plurality of disposable absorbent articles, the carton comprising:a wall defined by opposing first and second longitudinal edges and opposing first and second transversal edges, the wall comprising a frame having a first portion extending inwardly from the first longitudinal edge, a second portion extending inwardly from the second longitudinal edge and a third portion extending inwardly from the second transversal edge, the third portion having an inwardmost edge with an inwardly projecting portion defined by a first curve; and
a lid extending inwardly from a proximal portion at a hinge line proximate the first transversal edge, the lid having opposing longitudinal lid edges and a distal transversal lid edge, the transversal lid edge having a recessing portion defined by a second curve;
wherein the third portion, the inwardly projecting portion, the lid, and the recessing portion are sized and configured to permit closing of the lid and engagement of the recessing portion and the projecting portion in a configuration wherein the lid overlays the first and second portions of the frame and the recessing portion underlies the projecting portion.

US Pat. No. 10,363,174

EYE TISSUE MEASUREMENTS

AMO DEVELOPMENT, LLC, Sa...

1. A method for the precise incision of tissue in a cornea, comprising:docking a femtosecond laser patient interface to a cornea of a patient;
attenuating the femtosecond laser power to a level for measuring,
wherein the attenuated femtosecond laser has a power at the focus point of less than 40 milliwatts;
focusing the femtosecond laser to a beam at a focal point in the interior side of the cornea of the patient in x lateral axis, y lateral axis and a z depth axis;
moving the femtosecond laser focal point in the z axis from the interior side of the cornea through the cornea and toward an exterior side of the cornea;
capturing a backscatter of the femtosecond laser focal point as it moves in the z axis from the interior side of the cornea to the exterior side of the cornea; and
recording a time the femtosecond laser focal point moves in the z depth axis from the interior side of the cornea to the exterior side of the cornea;
calculating a power of the captured backscatter as the laser focal point moves in the z depth axis from the interior side of the cornea to the exterior side of the cornea;
determining a cutting distance, based on the recorded time the laser focal point moves and the calculated power of the captured backscatter;
powering up the femtosecond laser from the measuring power to an incision power; and
incising the cornea at the determined cutting distance in the cornea to remove a portion of the cornea.

US Pat. No. 10,363,173

CONFOCAL DETECTION TO MINIMIZE CAPSULOTOMY OVERCUT WHILE DYNAMICALLY RUNNING ON THE CAPSULAR SURFACE

OPTIMEDICA CORPORATION, ...

1. A method of modifying an intraocular target of an eye, the method comprising:focusing a treatment beam to a focal point at a first location in the eye so as to therapeutically alter tissue at the first location;
measuring an intensity signal of electromagnetic radiation reflected from the first location in response to the treatment beam;
identifying a second location in the eye using the measured intensity signal of the electromagnetic radiation reflected from the first location;
scanning the focal point toward the second location and altering tissue at the second location with the treatment beam; and
repeating the measuring step and the identifying step for the second location and a plurality of additional locations in the eye, and repeating the scanning step and the altering step to alter tissue at the plurality of additional locations in the eye with the treatment beam, wherein the altering of the tissue at the first, second and the plurality of additional locations collectively form an incision surface in the eye.

US Pat. No. 10,363,172

OPHTHALMIC LASER TREATMENT APPARATUS

NIDEK CO., LTD., Gamagor...

1. An ophthalmic laser treatment apparatus comprising:an aiming optical system configured to irradiate an aiming beam to a patient's eye;
a laser irradiation optical system configured to irradiate a laser beam for treatment to the patient's eye;
a shift unit configured to shift a focus shift position, which corresponds to a focus position of the laser beam, between maximum posterior and maximum anterior positions with respect to a focus position of the aiming beam;
a drive unit configured to drive the shift unit to shift the focus shift position;
a selection receiving unit configured to receive an instruction to select any one of a plurality of treatment modes; and
a processor and associated memory configured to control operations of the ophthalmic laser treatment apparatus, wherein:
the processor sets, according to the treatment mode selected with the selection receiving unit, a value of at least one parameter related to irradiation of the laser beam, and
the at least one parameter includes a parameter that includes an adjustment range of the focus shift position, the adjustment range being within and different from a maximum range of the focus shift position that is bounded by the maximum posterior and maximum anterior positions.

US Pat. No. 10,363,171

SYSTEM AND PROCESS FOR RETINA PHOTOTHERAPY

Ojai Retinal Technology, ...

1. A process for performing retinal photostimulation, comprising the steps of:generating a laser light comprised of a plurality of treatment light beams that creates a therapeutic effect to retinal tissue exposed to the laser light beams without destroying the retinal tissue;
simultaneously applying the treatment laser light beams to a first treatment area of the retina;
moving the laser light from the first treatment area to a second treatment area of the retina that is spaced apart from the first treatment area and simultaneously applying the treatment laser light beams to the second treatment area; and
within a predetermined period of time comprising less than one second, within a single treatment session, returning the laser light to the first treatment area and simultaneously reapplying the treatment laser light beams to the first treatment area.

US Pat. No. 10,363,170

APPARATUS FOR CORNEAL CROSSLINKING

Novartis AG, (CH)

1. An apparatus for corneal crosslinking, the apparatus comprising:a source of laser radiation having an energy and a pulse rate sufficient for creating photodisruption in a human cornea;
a scanner device configured to scan the laser radiation;
a control computer configured to control the scanner device;
a fluence reduction component selected to reduce the fluence of the laser radiation below a threshold at which corneal photodisruption occurs and at a level sufficient to activate a photosensitizer, wherein the fluence reduction component is, in response to an instruction from the control computer, configured to be alternatively moved to a first position out of a beam path of the laser radiation and moved to a second position into the beam path of the laser radiation, the fluence reduction component comprising a lens arrangement; and
the control computer further programmed to:
allow for the laser radiation having the energy and the pulse rate sufficient for creating photodisruption by moving the fluence reduction component to a first position out of the beam path of the laser radiation;
control the scanner device to create in the cornea, with the laser radiation, at least one incision for the introduction of or application of the photosensitizer into or onto the cornea; and
reduce the fluence of the laser radiation to the level sufficient to activate the photosensitizer for corneal crosslinking by moving the fluence reduction component to a second position into the beam path of the laser radiation.

US Pat. No. 10,363,169

SYSTEM AND METHOD FOR TREATING AN EYE

TEL HASHOMER MEDICAL RESE...

1. A method, comprising:providing a system that comprises a laser source and a hardware-implemented beam-shaping device comprising one or more optical elements;
generating electromagnetic radiation by the laser source; and
irradiating one or more regions of a trabecular meshwork of an eye with the electromagnetic radiation generated by the laser source, by directing the electromagnetic radiation using the beam-shaping device through an entire thickness of a scleral limbus of the eye without any contact with the eye.

US Pat. No. 10,363,168

OCULAR IMPLANTS FOR DELIVERY INTO THE EYE

IVANTIS, INC., Irvine, C...

1. A method of deploying at least a distal portion of an ocular implant into Schlemm's canal of an eye, the ocular implant comprising a plurality of curved supports, each support comprising a first end extending from a first location on a first side of the ocular implant and a second end extending from a second location on a second side of the ocular implant, the second location being proximal to the first location, so that each support forms a portion of a helix and the plurality of curved supports collectively forms a helix, the eye having a cornea defining an anterior chamber and an iris defining a pupil, the method comprising:advancing a distal portion of a cannula through the cornea so that a curved portion of the cannula is at least partially disposed in the anterior chamber of the eye;
advancing a distal tip of the cannula through trabecular meshwork of the eye so that a distal opening of the cannula is placed in fluid communication with Schlemm's canal;
advancing the ocular implant through the curved portion of the cannula;
rotating the ocular implant as at least a distal portion of the ocular implant is advanced through the distal opening and into Schlemm's canal; andusing the curved supports to advance the ocular implant into Schlemm's canal as the ocular implant is rotated.

US Pat. No. 10,363,167

DEVICE FOR AUTOMATED CAPSULOTOMY

Mynosys Cellular Devices,...

1. A surgical device for tissue cutting, the device comprising:a reversibly collapsible supporting element; and
a reversibly collapsible cutting element attached to the supporting element, the cutting element comprising:
an electrically conductive outer layer on an outer diameter of the supporting element, the outer layer comprising a layer of a first metal having a first resistivity and a layer of a second metal having a second resistivity lower than the first resistivity,
an electrically conductive inner layer on an inner diameter of the supporting element, the inner layer comprising a layer of the first metal and a layer of the second metal, and
an electrically conductive bottom layer on a bottom edge of the supporting element, the bottom layer being connected to the outer layer and the inner layer, the bottom layer having a third resistivity greater than the first resistivity and the second resistivity, the bottom layer configured to conduct an electrical current between the outer layer and the inner layer that causes a temperature increase in the bottom layer for cutting the tissue, the bottom layer comprising a layer of the first metal.

US Pat. No. 10,363,166

SYSTEM AND METHOD FOR CONTROLLING A TRANSVERSE PHACOEMULSIFICATION SYSTEM USING SENSED DATA

1. An apparatus configured for use in an ocular surgical procedure, comprising:a handpiece having a tip configured to ultrasonically vibrate, the handpiece configured to support a plurality of operating modes comprising a first operating mode and a second operating mode, wherein the plurality of operating modes are selected from the group consisting of transversal, longitudinal, and torsional;
a user interface configured to receive a relationship between a change in a system parameter and a change in a ratio between the first operating mode and the second operating mode, from a user;
a sensor configured to provide the change in the system parameter; and
a controller connected to the handpiece, the user interface, and the sensor, wherein the controller is configured to:
receive the relationship,
receive the change in the system parameter,
determine an operational ratio between the first operating mode and the second operating mode based on the change in the system parameter and the relationship;
dynamically select at least one operational parameter associated with the first operating mode and at least one operational parameter associated with the second operating mode, and
concurrently modify the at least one operational parameter associated with the first operating mode and the at least one operational parameter associated with the second operating mode to obtain the operational ratio between the first operating mode and the second operating mode.

US Pat. No. 10,363,165

INDEPENDENT SURGICAL CENTER

DOHENY EYE INSTITUTE, Lo...

1. A self-powered surgical system for a surgical procedure, comprising:a surgical tray;
a plurality of handheld instruments;
a power source in at least one of the surgical tray and a handheld instrument;
and a processing unit;
wherein the processing unit is configured to execute program instructions, the program instructions including instructions for:
detecting power from the at least one power source;
directing power to the plurality of handheld instruments from the at least one power source;
wirelessly detect identification information from at least one of the plurality of handheld instruments;
establishing communication with each of the plurality of handheld instruments; and
transmit an initial configuration setting to at least one of the plurality of handheld instruments based on the identification information.

US Pat. No. 10,363,164

TOOL AND TOOL SYSTEM HAVING INDEPENDENT AXIAL AND TRANSVERSE FORCE SENSING

The Johns Hopkins Univers...

1. A force-sensing tool, comprising:a tool shaft comprising a proximal end and a distal end;
a flexure section attached at a first end to said distal end of said tool shaft;
a tool tip operatively connected to said flexure section such that axial forces applied to said tool tip are coupled primarily to a first portion of said flexure section and transverse forces applied to said tool tip are coupled primarily to a second portion of said flexure section;
an axial force sensor coupled to said first portion of said flexure section; and
a transverse force sensor coupled to said second portion of said flexure section,
wherein said first portion of said flexure section is substantially free to move in an axial direction relative to said second portion of said flexure section,
wherein said axial force sensor responds to axial forces applied to said tool tip substantially independently of said transverse forces applied to said tool tip under a designed operating range of forces, and
wherein said transverse force sensor responds to transverse forces applied to said tool tip substantially independently of said axial forces applied to said tool tip under said designed operating range of forces.

US Pat. No. 10,363,163

INJECTOR APPARATUS

EYEPOINT PHARMACEUTICALS,...

1. An injector device, comprising:a housing;
a cannula defining a lumen and having a proximal end received in the housing and a distal end extending from the housing; wherein the cannula further comprises an aperture that is located in a wall of the cannula between the proximal end of the cannula and the distal end of the cannula;
a hollow needle comprising a distal end with a tip for piercing a tissue;
a shifter that shifts the needle from an extended position to a retracted position; and
an actuator for advancing a payload from an initial position to exit from the distal end of the cannula,
wherein the device is configured so that, in the extended position, the needle extends through the aperture and occupies at least part of the lumen of the cannula, and the distal end of the needle extends past the distal end of the cannula;
wherein, when the needle is shifted from the extended position to the retracted position, the tip of the needle exits the lumen of the cannula through the aperture, and
wherein, in the retracted position, the distal end of the needle is withdrawn from the lumen of the cannula sufficiently to permit the payload to advance from the initial position through the distal end of the cannula.

US Pat. No. 10,363,162

DEVICES AND METHODS FOR CONTROLLING PATIENT TEMPERATURE

ADVANCED COOLING THERAPY,...

1. A method for cooling esophageal tissue in a patient undergoing a cardiac ablation procedure, the method comprising:nasally or orally inserting a heat transfer device into the patient, wherein the heat transfer device comprises one or more lumens providing a fluid path for flow of a heat transfer medium, a heat transfer region having a diameter of about 1.0 to about 2.0 centimeters, and a gastric tube that, when the heat transfer region is positioned in an esophagus of the patient, extends into a stomach of the patient; and
initiating flow of the heat transfer medium along the fluid path.

US Pat. No. 10,363,161

SLEEP APNEA ORAL APPLIANCE FOR USE DURING ORTHODONTIC TREATMENT

SELANE PRODUCTS, INC., C...

1. A method for accomplishing an orthodontic treatment while treating snoring and/or sleep apnea in a subject, comprising:applying a first orthodontic tray to maxillary dentition of a subject, wherein the first orthodontic tray has an anterior portion, a posterior portion, a right side, a left side, an inner surface, and an outer surface, wherein the inner surface of the first orthodontic tray contacts at least some of the subject's maxillary dentition;
applying a second orthodontic tray to mandibular dentition of the subject, wherein the second orthodontic tray has an anterior portion, a posterior portion, a right side, a left side, an inner surface, and an outer surface, wherein the inner surface of the second orthodontic tray contacts at least some of the subject's mandibular dentition;
applying a first appliance tray over the first orthodontic tray, the first appliance tray having an anterior portion, a posterior portion, a right side, a left side, a buccal side, a lingual side, an inner surface, and an outer surface, wherein a receptacle formed in the inner surface of the first appliance tray contacts and surrounds at least a portion of the outer surface of the first orthodontic appliance; and
applying a second appliance tray over the second orthodontic tray, the second appliance tray having an anterior portion, a posterior portion, a right side, a left side, a buccal side, a lingual side, an inner surface, and an outer surface, wherein a receptacle formed in the inner surface of the second appliance tray contacts and surrounds at least a portion of the outer surface of the second orthodontic appliance,
wherein the first appliance tray and second appliance tray cooperate to maintain the mandible of the subject in a relatively forward position during use, thereby treating snoring and/or sleep apnea in the subject.

US Pat. No. 10,363,160

MANDIBULAR REPOSITIONING DEVICE

ResMed SAS, Saint Priest...

1. An intra-oral device designed to fit in a patient's mouth, comprising:an upper splint, structured to engage with at least a portion of one or more teeth on the maxilla, wherein the upper splint includes at least one upper gutter portion, that engages with a portion of one or more teeth on the maxilla, to retain the upper splint on the maxilla; and
a lower splint, structured to engage with at least a portion of one or more teeth on the mandible, wherein the lower splint include at least one lower gutter portion, that engages with a portion of one or more teeth on the mandible, to retain the lower splint on the mandible,
wherein:
the thickness of at least one of the at least one upper gutter portion and the at least one lower gutter portion varies across a profile of the teeth,
at least one of the at least one upper gutter portion and the at least one lower gutter portion has a retention portion with a varied thickness profile, and
the retention portion has an inside surface shaped and dimensioned to engage a side wall of the tooth, the inside surface including an undercut portion adapted to hold the device on the tooth, the undercut portion having a length that is adapted to extend from an apex of the tooth to a sub-apex position adjacent the apex and oriented towards the gingival part of the patient's tooth, the inside surface having a shape adapted to engage the tooth side wall continuously from substantially a distal end of the tooth side wall, continuing through the apex, and to the sub-apex position, wherein (a) the inside surface is configured to diverge away and be spaced from the tooth side wall at a position of the side wall between the sub-apex position and the gingival part of the patient's tooth, and (b) the retention portion has a distal end configured to diverge away and be spaced from the patient's gum.

US Pat. No. 10,363,159

PAIN MANAGEMENT AND POST-OPERATIVE HIP ORTHOSIS

1. An orthosis comprising:a waist strap having opposed first and second ends and a lateral portion therebetween, the first and second ends having coupling means for coupling the first and second ends;
a lower strap having opposed first and second ends and a lateral portion therebetween, the first and second ends of the lower strap having coupling means for coupling the first and second ends of the lower strap;
a pocket extending between the waist strap and the lower strap, the pocket comprising an inner panel and an outer panel fastened to each other to define an upper opening at a top of the pocket and a lower opening at a bottom of the pocket, the upper opening larger than the lower opening; and
an abduction harness, for laterally abducting a leg, comprising two upper straps and a lower strap coupled to each other at a central union, wherein the upper straps are secured to the top of the pocket, and the lower strap is secured to the bottom of the pocket;
wherein the top of the pocket is secured to the lateral portion of the waist strap, and the first and second ends of the lower strap are secured on the bottom of the pocket.

US Pat. No. 10,363,158

ATHLETE FINGER GUARD

1. A guard configured to protect a finger while allowing finger mobility during athletic activity, the injured finger having a distal part, a proximal part, a fingertip on the distal part, a fingernail near the fingertip, a nail bed just proximal of the fingernail, a proximal interphalangeal joint between the distal part and proximal part, a superior surface and an inferior surface, the guard comprising:a core having a distal segment and a proximal segment, the proximal segment and distal segment each having a top surface and a bottom surface, the core adapted for receiving the superior surface of the finger along the bottom surfaces of the proximal and distal segments, the proximal segment has side extensions having rear side edges that substantially oppose each other, the proximal segment curves transversely downwardly toward the rear side edges, the distal segment has a distal end and a distal end edge at the distal end, the distal segment has forward side edges extending proximally from the distal end edge, the rear side edges at the proximal segment extend wider than the forward side edges at the distal segment, the distal segment adapted for receiving the distal part of said finger and the proximal segment adapted for receiving the proximal part of said finger, the distal segment extending on top of but not alongside the distal part of the finger, and extending toward the fingertip to substantially the nail bed; and
a hinge assembly, located above the top surfaces of the proximal and distal segments, and positioned just distal of the proximal interphalangeal joint and the side edges of the proximal segment extending alongside the proximal part of the finger, the hinge assembly including a pair of brackets on the proximal segment having a flat bridge surface therebetween, and a fin rib attached to the distal segment and extending distally thereon, the fin rib extends between the brackets and protrudes upwardly from the top surface of the distal segment, centered between the forward side edges and tapering downwardly toward the top surface as it extends distally, the fin rib has a tongue that interacts with the bridge surface to limit movement of the hinge assembly such that the distal part reaches a maximum position where the bottom surfaces of the proximal part and distal part do not fully align but instead form an obtuse angle that thereby is adapted to prevent the finger from fully straightening.

US Pat. No. 10,363,157

TORQUE GENERATING POUCH AND RELATED METHODS

Rehabilitation Institute ...

1. An apparatus, comprising:a. a material pouch defining a volume of space, the material pouch comprising a flexible portion and having a first surface and a second surface;
b. the material pouch having a first position, in which the material pouch is bent along the flexible portion and the first surface contacts the second surface at an interface;
c. wherein, when the material pouch is in the first position, an increase in pressure to the space creates a force between the first surface and the second surface; and
d. wherein the material pouch transitions from the first position to a second position in response to the force between the first surface and the second surface.

US Pat. No. 10,363,156

GASTRIC TUBES HAVING TETHERED PLUGS AND METHODS OF USE

Covidien LP, Mansfield, ...

1. A gastric tube for use in a bariatric procedure, the gastric tube comprising:an elongate tube having a proximal end portion and a distal end portion, the elongate tube defining a lumen along a length thereof, the proximal end portion defining an opening in communication with the lumen, the elongate tube including:
a blunt tip formed on the distal end portion; and
an outer surface that extends between the proximal and distal end portions and defines a side opening in communication with the lumen, the side opening configured and dimensioned for at least one of aspiration or irrigation;
a balloon supported on the elongate tube and configured to receive an inflation medium to inflate the balloon; and
a cannulated plug coupled to the elongate tube, the cannulated plug including:
a proximal end configured for connection to a vacuum source; and
a distal end configured for removable receipt in the opening of the proximal end portion of the elongate tube to control a flow of one of aspiration or irrigation through the lumen, wherein the cannulated plug tapers between the proximal end and the distal end thereof.

US Pat. No. 10,363,155

STENT GRAFT

JOTEC GMBH, Hechingen (D...

1. A stent graft comprising:a hollow cylindrical body and
a sleeve catheter,
wherein the body has at least one self-expanding stent and a prosthetic material, wherein the body, in a compressed state, has a circumference that is smaller than a circumference of the body in an expanded state,
wherein the sleeve catheter is designed as a flap-shaped compression element having two longitudinal edges, a first longitudinal edge and a second longitudinal edge,
wherein the first longitudinal edge is fixedly secured bar stitching the first longitudinal edge to the prosthetic material of the body,
wherein an extent of the flap-shaped compression element perpendicular to the first longitudinal edge is smaller than the circumference of the body in the expanded state, wherein, for the purpose of compressing the body, the flap-shaped compression element can be placed around the body, and wherein the second longitudinal edge is not attached to the prosthesis material of the body and is releasably attachable to fixation points arranged on the flap-shaped compression element.

US Pat. No. 10,363,154

STENT DESIGNS FOR USE WITH ONE OR MORE TRIGGER WIRES

Cook Medical Technologies...

1. A prosthesis comprising:a graft having a first end, a second end, a first edge at the first end, and a second edge at the second end, each of the first and second graft edges at the ends of the graft;
an expandable stent attached to the graft at one of the ends of the graft, and having a first end, a second end, and a plurality of apices at the second end, each apex having a surface;
a suture bore disposed through the surface of each of the plurality of apices of the second end of the stent, the suture bore disposed inwardly of an edge of the graft;
an imaging bore disposed through the surface of each of the plurality of apices of the second end of the stent, the imaging bore disposed directly axially adjacent the suture bore;
an imaging element disposed in each imaging bore;
wherein each imaging element is aligned with one of the first and second edges of the graft such that the location of the imaging element corresponds with the edge of the graft with which it is aligned and provides exact imaging of the edge of the graft.

US Pat. No. 10,363,152

HELICAL HYBRID STENT

Medinol Ltd., Tel Aviv (...

1. A stent comprising:a helical main stent component having a tubular structure extending from a first end to a second end, the helical main stent component having a first side band and a second side band, wherein the first and second side bands are coextensive and wherein each of the first side band and the second side band has an undulating pattern and forms a plurality of helical windings;
a polymer material interconnecting the plurality of the helical windings, wherein the polymer material extends in gaps between the plurality of helical windings; and
a drug included with at least one of the group consisting of the helical main stent component and the polymer material.

US Pat. No. 10,363,151

DEVICE FOR ENDOVASCULAR AORTIC REPAIR AND METHOD OF USING THE SAME

Aortic Innovations, LLC, ...

1. A vascular prosthesis assembly comprising:a first prosthetic component comprising:
a first stent device having a wireframe assembly, the wireframe assembly defining a top portion that spans but does not extend into, the brachiocephalic artery, left common carotid artery, and left subclavian artery when placed within the aortic arch of a patient;
a prosthesis portion on an end of the first prosthetic device, the prosthesis portion being a covered graft material and configured to engage with a first portion of the aortic arch;
a second prosthetic component comprising:
a prosthesis portion configured for being stitchably engaged with the prosthesis portion of the first prosthetic device, wherein the prosthesis portion of the second prosthetic device is configured for engaging a second portion of the aorta, wherein the second portion is spaced-apart from the first portion and configured for engaging with a valve of the patient or prosthetic valve element;
wherein the first prosthetic component is placed into engagement with the first portion of a patient's aorta and the second prosthetic component is then secured to the first prosthetic component at the second portion of the patient's aorta to thereby define a total length of the combined first and second prosthetic components.

US Pat. No. 10,363,150

PROSTHETIC DEVICE WITH A ROTATABLE PYRAMID AND LATERAL TRAVEL LIMIT

American Prosthetic Compo...

1. A device comprising:a first member with a bar and a central hole, said central hole receiving a limiter;
a second member having a ring with a diameter; and
a third member with a channel and a tapered hole, said bar being laterally movably received within said channel and said second member being received within said tapered hole, said third member being laterally adjustable relative to said first member by a distance that is no greater than said diameter of said ring as said limiter contacts said ring at outer travel limits preventing additional lateral travel of said bar relative to said channel.

US Pat. No. 10,363,149

HIP REPLACEMENT NAVIGATION SYSTEM AND METHOD

OrthAlign, Inc., Aliso V...

1. A method of performing a hip joint replacement procedure, the hip joint comprises a pelvis and a femur that is movable relative to the pelvis, the method comprising:placing a patient in a position with the femur of the hip joint in an extended position;
mounting a laser projecting device to the pelvis adjacent to the hip joint;
projecting a laser light onto a target to illuminate a portion of the target away from the hip joint;
recording a position of an incidence of the laser light;
positioning an acetabular shell after recording the position;
projecting the laser light onto the target after positioning the acetabular shell; and
aligning the femur with the pelvis by aligning the recorded position with the incidence of laser light.

US Pat. No. 10,363,146

OSTEOTOMY PROTECTIVE COVER

DePuy Synthes Products, I...

1. A cover for use in protecting a resected surface of a long bone for use in joint arthroplasty, comprising:a body;
a plurality of independently moveable members moveably attached to the body, two of the plurality of independently movable members configured to move linearly with respect to the body along a first plane and along a first axis, the body and the plurality of independently moveable members having a first configuration and a second configuration, the first configuration defining a first periphery of the cover along the first plane, the second configuration defining a second periphery of the cover along the first plane, wherein the first periphery encompasses a first area when projected onto the first plane and the second periphery encompasses a second area when projected onto the first plane, the second area larger than the first area and including all of the first area; and
a lip fixedly extending downwardly along an outer radial periphery of one of the body and the plurality of independently moveable members in a direction not co-planar with the first plane, the lip having an inwardly facing portion, the inwardly facing portion configured such that when the cover is positioned on the resected surface of the long bone, the inwardly facing portion can abut a surface of the long bone extending about the resected surface.

US Pat. No. 10,363,145

LATERAL PLATE AND SPINAL IMPLANT SYSTEM AND METHOD

1. A lateral plate assembly comprising:an elongated lateral plate for attachment to adjacent vertebrae having a first closed end portion and a second closed end portion, a top surface and a bottom surface, and a pair of apertures, a first aperture extending through the top surface and the bottom surface, a second aperture communicating with a slot and positioned in a first surface below the top surface and extending through the bottom surface, the first aperture having an opening positioned in the first closed end portion for receiving a first bone screw and the second aperture communicating with the slot to receive a second bone screw, the slot extending toward the second closed end portion, the second closed end portion being defined by an open end above the second closed end portion; and
wherein the open end and a pair of sides with grooves and overhanging lips is configured for receiving and holding a moveable washer on top of the second aperture communicating with the slot, the washer after being slid through the open end being configured to move along a length of the second aperture communicating with the slot, the moveable washer having an inner surface defining an opening, a head of the second bone screw held by the inner surface, movement of the washer relative to the second aperture communicating with the slot increases or decreases the distance between locations of a head of the first bone screw and the head of the second bone screw.

US Pat. No. 10,363,144

EXPANDABLE SPINAL IMPLANT

41MEDICAL AG, Bettlach (...

1. An expandable spinal implant assembly for insertion between two adjacent vertebral bodies, comprising:a) a substantially hollow first body with a first superior endplate with a first top inside face and a first inferior endplate with a first bottom inside face, said first superior endplate and said first inferior endplate being connected together on at least one side by a lateral wall;
b) at least one strut being arranged within said first body and connecting the first top inside face of said superior endplate with the first bottom inside face of said inferior endplate, said strut comprising a first threaded through bore with a central axis;
c) a substantially hollow second body with a second superior endplate and a second inferior endplate, said second body being at least partially inserted within said first body;
d) a central screw with a first end comprising a ball-head and a drive, said central screw further having a threaded shaft which is engaged within said first threaded through bore,
wherein
at least one track is arranged on a second top inside face of said second superior endplate and/or on a second bottom inside face of said second inferior endplate, said at least one track being oriented at an acute angle relative to the central axis of said first threaded through bore when said substantially hollow second body is at least partially inserted into said substantially hollow first body and wherein said ball-head of said central screw is engaged into said at least one track.

US Pat. No. 10,363,143

HARVESTING BONE GRAFT MATERIAL FOR USE IN SPINAL AND OTHER BONE FUSION SURGERIES

1. A bone cutter assembly for harvesting bone graft material for use in fusion surgery, comprising:an elongated cannula extending from a proximal end to a distal end along a longitudinal axis, said elongated cannula having a bend formed at the distal end or a distal tip of the cannula, and having a through bore extending along said longitudinal axis through said proximal end and said distal tip of the cannula, wherein the cannula is constructed and arranged to be supported at inserted to a desired position in a space between bones to be fused; and
an elongated wire having a cutting distal tip, wherein the wire is inserted through the through bore of the cannula so that the cutting distal tip is configured to extend a desired distance distally beyond the distal tip of the elongated cannula for contacting the bones to be fused, and the cutting tip is operative to cut grooves in the bones when the cannula is rotated about its axis by an outside drive so that a slurry of morselized bone and blood effuses from the grooved bones to promote fusion of the bones;
the cannula has an elongated side slot opens the through bore into an outside of the elongated cannula and a proximal end of the wire in the cannula is bent to project radially through the slot, and including a first proximal knob mounted coaxially on the cannula for sliding movement over the slot, wherein the proximal end of the wire is captured by the first knob so that the cutting tip of the wire is configured to be set to extend a desired distance from the distal end of the cannula according to the position of the first knob over the slot;
a second distal knob mounted coaxially for sliding movement over the elongated cannula and for rotation about the longitudinal axis relative to the cannula, wherein the second distal knob comprises a retaining collar mounted coaxially over the elongated cannula and having radially extending ears configured to engage by friction a fixed surface of a device in the region of the bones to be fused for supporting the cannula at the desired position in the space between the bones;
two stop rings mounted coaxially on a distal portion of the elongated cannula and at corresponding distal and proximal sides of the second distal knob, for limiting the axial sliding of the elongated cannula relative to the second distal knob when the distal end is inserted into the space between the bones to be fused and the retaining collar is engaged to the fixed surface, so that a surgeon can define the location and the overall width of a series of cuts to be made by the cutting tip of the wire into bone above and below the distal end of the cannula by adjusting the axial positions of the stop rings over the length of the cannula at the sides of the second knob; and
wherein the axial sliding of the second distal knob along the elongated cannula causes the retaining collar to slide axially along the elongated cannula, and the rotation of the second distal knob about the longitudinal axis relative to the elongated cannula causes the retaining collar to rotate about the longitudinal axis relative to the elongated cannula.

US Pat. No. 10,363,142

EXPANDABLE SPINAL IMPLANTS

K2M, Inc., Leesburg, VA ...

1. A spinal implant having a proximal region and a distal region, the spinal implant comprising:an upper body including an outer surface and an inner surface;
a lower body including an outer surface and an inner surface, the inner surfaces of the upper and lower bodies disposed in opposed relation relative to each other;
a proximal adjustment assembly disposed between the upper and lower bodies at the proximal region of the spinal implant and adjustably coupled to the upper and lower bodies; and
a distal adjustment assembly disposed between the upper and lower bodies at the distal region of the spinal implant and adjustably coupled to the upper and lower bodies, the proximal and distal adjustment assemblies independently movable to change a vertical height of at least one of the proximal region or the distal region of the spinal implant, the distal adjustment assembly including:
a pivot linkage assembly including an upper pivot linkage pivotably connected to the inner surface of the upper body and a lower pivot linkage pivotably connected to the inner surface of the lower body, the upper and lower pivot linkages pivotably connected to each other and movable with respect to each other to change the vertical height of the distal region of the spinal implant;
a threaded post including a distal end movable into and out of contact with the pivot linkage assembly to effect movement of the upper and lower pivot linkages with respect to each other; and
an expander including a body portion defining a cavity therein and a distal end including a double ramped inner surface, wherein the pivot linkage assembly extends through the cavity of the expander such that the upper and lower pivot linkages contact the double ramped inner surface of the expander when moved by the threaded post.

US Pat. No. 10,363,141

ARTIFICIAL DISC

AXIOMED, LLC, Malden, MA...

1. An artificial disc to replace a damaged spinal disc in a spinal column, said artificial disc comprising:a first plate having an outer side engagable with a first vertebra of the spinal column and an inner side,
a second plate having an outer side engagable with a second vertebra of the spinal column and an inner side, and
a resilient core disposed between said first and second plates, said resilient core being fixedly bonded to said inner sides of said first and second plates by molding the resilient core to the first and second plates,
said inner side of at least one of said first and second plates having an array of recesses which includes a plurality of recesses into which said resilient core is molded and extends,
wherein each one of said recesses comprises a bottom portion having a polygonal configuration and being configured to be filled with and comprising molded resilient core material,
wherein said plurality of recesses are integrally formed in the entire inner side of said at least one plate of said first and second plates and wherein each one of said recesses of said plurality of recesses has surfaces which are integrally formed as one piece with said at least one plate of said first and second plates,
wherein the resilient core comprises a material that is configured to flow into each of one said recesses by heating and softening the material, and
wherein the second plate comprises a peripheral flange that restricts transverse or sideways deflection of the resilient core.

US Pat. No. 10,363,139

BALL AND SOCKET ASSEMBLY

MOXIMED, INC., Fremont, ...

1. A ball and socket assembly, comprising:a generally non-deformable ball component having a surface forming a portion of a sphere;
an elongated shaft coupled to said ball component;
a single piece, generally non-deformable socket component, the socket including a bearing surface defining a contour assuming a portion of a sphere and an opening that is smaller than the diameter of the ball component in at least one diameter;
wherein the ball component includes a cavity formed therein; and
wherein the assembly includes a filler component sized to fit the cavity.

US Pat. No. 10,363,138

DEVICES FOR ADJUSTING THE CURVATURE OF CARDIAC VALVE STRUCTURES

EVALVE, INC., Santa Clar...

1. An interventional system for temporarily adjusting the structure of a heart, the system comprising:a curvature device moveable between a collapsed configuration having a profile suitable for delivery of the device to a coronary sinus and great cardiac vein of a patient and an expanded configuration having a profile suitable for lodging of the device at the coronary sinus and great cardiac vein, the curvature device including:
a distal end section, at least a portion of the distal end section being configured to anchor within the great cardiac vein when deployed to the expanded position at the great cardiac vein;
a proximal end section, at least a portion of the proximal end section being configured to anchor within the coronary sinus when deployed to the expanded position at the coronary sinus; and
a tether disposed at the distal end section and extending through and past the proximal end section, the tether being tensionable such that an increase in tension increases the curvature of the device, and a release of tension lessens the curvature of the device,
a delivery catheter having a proximal end and a distal end, the delivery catheter including a sheath at the distal end configured to house the curvature device to maintain the curvature device in the collapsed configuration while housed within the sheath; and
a handle coupled to the proximal end of the delivery catheter, the tether extending to the handle, the handle including a tether control operatively coupled to the tether to enable adjusting of tension in the tether through actuation of the control and including a deployment control operatively coupled to the sheath or curvature device to enable proximal retraction of the sheath or distal pushing of the curvature device.

US Pat. No. 10,363,137

IMPLANTATION OF REPAIR DEVICES IN THE HEART

Valtech Cardio, Ltd., Or...

1. An apparatus, comprising:a plurality of helical tissue anchors; and
an annuloplasty structure for placement on an annulus of a heart valve, the annuloplasty structure comprising:
a plurality of compressible subunits, and
a plurality of anchor mounts alternately disposed with respect to the plurality of compressible subunits, each anchor mount defining a path for passage of a respective one of the plurality of helical tissue anchors;
wherein the annuloplasty structure can be transitioned from a first configuration having a first diameter to a second configuration having a second diameter different from the first diameter.

US Pat. No. 10,363,136

IMPLANT HAVING MULTIPLE ADJUSTMENT MECHANISMS

Valtech Cardio, Ltd., Or...

1. A method for use with an implant structure, a first tool, a second tool, and a longitudinal guide member, the implant structure including (i) a body portion, (ii) a first implant-adjustment mechanism coupled to the body portion and configured to adjust the implant structure, and (iii) a second implant-adjustment mechanism coupled to the body portion, the method comprising:delivering the implant structure to a heart of a subject while the first implant-adjustment mechanism is coupled to the first tool, and the second implant-adjustment mechanism is coupled to the longitudinal guide member;
subsequently, coupling the implant structure to tissue of the heart; and
subsequently, advancing the second tool along the longitudinal guide member to the second implant-adjustment mechanism, the second tool configured to actuate the second implant-adjustment mechanism.

US Pat. No. 10,363,135

APPARATUS AND METHODS FOR DELIVERY OF TRANSCATHETER PROSTHETIC VALVES

Tendyne Holdings, Inc., ...

12. A method, comprising:inserting a prosthetic heart valve into an interior region of a valve loading device while in a biased expanded configuration;
moving the prosthetic heart valve from the biased expanded configuration to a compressed configuration while disposed within the valve loading device;
transferring the prosthetic heart valve while in the compressed configuration from the valve loading device to a valve holding tube;
after transferring the prosthetic heart valve to the valve holding tube, coupling the valve holding tube with the prosthetic heart valve disposed therein in the compressed configuration to a distal end portion of a handle assembly; and inserting a sheath of a catheter assembly into a heart.

US Pat. No. 10,363,134

DEVICE FOR THE IMPLANTATION AND FIXATION OF PROSTHETIC VALVES

JenaValve Technology, Inc...

1. A method of treating a native aortic valve, the method comprising:positioning a first expandable stent component adjacent the native aortic valve, the first stent component including three struts, wherein the three struts include exactly one strut for placement between each leaflet of the native aortic valve and a wall of an aorta, wherein each strut includes an apex pointing in a proximal direction towards a native heart;
expanding the struts of the first stent component;
after expanding the struts, positioning each strut between the respective leaflet and the wall of the aorta, wherein the struts align the first stent component with the native aortic valve in an axial direction;
positioning a second expandable stent component radially inward of the leaflets of the native aortic valve and of the first stent component, wherein the second stent component includes a prosthetic heart valve; and
expanding the second stent component to press the leaflets of the native aortic valve radially outward toward the first stent component, such that the leaflets of the native aortic valve are positioned between the first stent component and the second stent component.

US Pat. No. 10,363,133

METHODS AND APPARATUS FOR ENGAGING A VALVE PROSTHESIS WITH TISSUE

Neovac Tiara Inc., Richm...

1. A system for deploying a prosthetic valve, said system comprising:a prosthetic cardiac valve comprising an atrial skirt, a ventricular skirt, and a tab coupled to the ventricular skirt; and
a delivery system comprising an outer sheath and pusher element, wherein the prosthetic cardiac valve is carried by the delivery system and the pusher element is slidably disposed under the outer sheath,
wherein partial retraction of the outer sheath releases a constraint from the atrial skirt and the ventricular skirt thereby allowing self-expansion thereof, and
wherein further retraction of the outer sheath releases a constraint from the tab thereby allowing a tip of the tab to radially self-expand outward forming a window between an edge of the atrial skirt and the tip of the tab, and
wherein a base portion of the tab remains constrained by the outer sheath and actuation of the pusher element into engagement with the base portion actuates the tip of the tab to open the window to its maximum size, and
wherein further retraction of the outer sheath or further actuation of the pusher element removes the constraint from the base portion of the tab, thereby at least partially closing the window.

US Pat. No. 10,363,132

PROSTHETIC HEART VALVE HAVING IMPROVED COMMISSURE SUPPORTS

Edwards Lifesciences Corp...

1. A prosthetic valve comprising:a radially collapsible and expandable annular frame, the frame comprising an inlet end and an outlet end, the frame comprising a plurality of angularly spaced, commissure attachment portions, each comprising two inner struts and two outer struts; and
a leaflet structure comprising a plurality of leaflets, each leaflet comprising opposing side portions, an upper edge extending between the side portions, and a lower edge extending between the side portions;
wherein each side portion of a leaflet is paired with an adjacent side portion of another leaflet to form commissures of the leaflet structure supported by respective commissure attachment portions, wherein each pair of adjacent side portions extends through a gap between the inner struts of a corresponding commissure attachment portion and one side portion of the pair is folded to form a first fold layer that extends through a gap between one of the inner struts and one of the outer struts of a corresponding commissure attachment portion and the other side portion of the pair is folded to form a second fold layer that extends through a gap between the other inner strut and the other outer strut of the corresponding commissure attachment portion;
wherein the leaflets are movable between an open position to allow blood to flow through the prosthetic valve from the inlet end to the outlet end and a closed position to inhibit the flow of blood through the prosthetic valve from the outlet end to the inlet end.

US Pat. No. 10,363,131

AORTIC INSUFFICIENCY VALVE PERCUTANEOUS VALVE ANCHORING

St. Jude Medical, Cardiol...

1. A method of implanting a stented device in a cardiovascular system of a mammalian subject, the method comprising:guiding a delivery device having an anchoring device connected to a distal end thereof within the cardiovascular system to a target location, the anchoring device having a body and a mooring feature extending from the body;
anchoring the anchoring device at the target location by penetrating tissue at the target location with the mooring feature, the mooring feature being configured to anchor the body to the tissue when penetrated therein;
guiding the stented device through the cardiovascular system to the target location; and
deploying the stented device such that a native valve leaflet is positioned between a stent of the stented device and the anchoring device and so that, when the native valve leaflet is positioned between the stented device and the anchoring device, the stented device and the anchoring device together pinch the native valve leaflet to create a pinching effect on the native valve leaflet so as to restrict movement of the stented device within the cardiovascular system.

US Pat. No. 10,363,130

DEVICES AND SYSTEMS FOR DOCKING A HEART VALVE

Edwards Lifesciences Corp...

1. An expandable docking station for an expandable valve comprising:a valve seat that is substantially unexpandable beyond a deployed size;
one or more sealing portions connected to the valve seat that are constructed to expand radially outward of the valve seat and provide a seal over a range of sizes; and
one or more retaining portions connected to the one or more sealing portions that are configured to retain the docking station at a deployed position;
wherein the valve seat and the one or more sealing portions act as an isolator that reduces or prevents radial outward forces of an expandable valve in the valve seat from being transferred to the one or more sealing portions or the one or more retaining portions.

US Pat. No. 10,363,129

VARIABLE STRENGTH INTRAOCULAR LENS AND METHOD OF USING SAME

Mag Optics, London (GB)

1. A variable optical strength intraocular lens comprising:a lens complex comprising:
an anterior segment comprising an anterior lens,
a posterior segment comprising a posterior lens portion and a haptic plate portion, wherein the haptic plate portion surrounds an optical zone, and
at least one spring in contact with the anterior segment and the posterior segment to provide a separation distance between the anterior lens and the posterior lens portion, and
at least one spring comprises one, two, three, four, or more than four springs having a C-shaped cross-section; and
a ciliary haptic complex comprising:
a central ring,
a first pair of ciliary muscle haptics extending outwardly from the central ring, and
a second pair of ciliary muscle haptics extending outwardly from the central ring wherein upon insertion into an eye, the central ring is in contact with an inferior side of the anterior lens and the first pair of ciliary muscle haptics and the second pair of ciliary muscle haptics are in communication with ciliary muscle of the eye and wherein contraction of the ciliary muscle causes the separation distance between the anterior lens and the posterior lens to increase.

US Pat. No. 10,363,128

DEVICE AND METHOD FOR PROSTHETIC REHABILITATION OF THE RETINA

1. A device for prosthetic vision rehabilitation, the device comprising:a scleral explant with a shape that is suitable for being in contact with at least one portion of the sclera of an eye;
at least one inducer arranged on the scleral explant, and
an insulating layer arranged on the at least one inducer, the at least one inducer constructed and arranged to create an electromagnetic field for neuronal stimulation of ganglionic neurons of the eye, the insulating layer galvanically insulating the at least one inducer from an excitation zone where the ganglionic neurons are located.

US Pat. No. 10,363,127

MESH POUCH FOR MEDICAL IMPLANT AND METHOD FOR USING SAME

SURGICAL INNOVATION ASSOC...

1. A mesh pouch for holding a surgical implant within a patient's body, the mesh pouch comprising:a mesh wall that defines an enclosure having an opening at an end of the enclosure;
a drawstring configured to close the opening when drawn so as to prevent the surgical implant from leaving the enclosure; and
a mesh tab extending from the mesh wall, the mesh tab providing a surface for suturing the mesh pouch to an inner surface of the patient's body.

US Pat. No. 10,363,126

ARTHROSCOPIC TENODESIS TOOL

1. A method for performing arthroscopic tenodesis on a joint having a tendon, comprising the steps of:a. severing the tendon;
b. using a guide comprising an elongate member having a length with a distal portion having one or more spring arms configured to open toward a free end of the distal portion of the guide to directly and releasably engage a tendon, and directly engaging the tendon with one or more of the spring arms;
c. forming a tunnel or channel into the joint from a location at the outside of the joint to a bone within the joint;
d. using the guide to urge the tendon down the tunnel or channel to the bone;
e. applying force to the guide to imbed an end of the guide into the bone;
f. sliding a cannulated fixation screw along the guide to the bone and rotating the fixation screw to seat the fixation screw into the bone and fix the tendon to the bone;
g. releasing the tendon from the guide; and
h. removing the guide in its entirety from the bone and withdrawing the guide in its entirety from the joint.

US Pat. No. 10,363,125

METHOD OF MAKING IMPLANTABLE MEDICAL DEVICES HAVING CONTROLLED SURFACE PROPERTIES

Vactronix Scientific, LLC...

1. A method for controlling surface properties of an implantable medical device, comprising:a. vacuum depositing at least one device forming metal selected from one of elemental nickel, elemental titanium, chromium-cobalt alloy, nickel-titanium alloy and nickel-titanium ternary alloy onto a cylindrical substrate maintained at a temperature range between about 300 to 1100 degrees Centigrade, to form a tubular device forming biomaterial on the cylindrical substrate;
b. controlling the formation of heterogeneities at a blood or tissue contacting surface of the tubular device forming biomaterial during the vacuum depositing step, such that controlled heterogeneities are formed at the blood or tissue contacting surface; and
c. removing the formed biomaterial from the substrate.

US Pat. No. 10,363,124

METHODS AND APPARATUSES FOR FORMING FIBROUS TUBES

HUMACYTE, INC., Durham, ...

1. A system for forming tubular scaffolds for tissue engineering, comprising:a mandrel with an outer circumference configured to receive a strip of scaffolding material wound there around;
at least one first structure configured with at least one first recess configured to receive at least a first portion of the circumference of the mandrel with the wound scaffolding material;
at least one second structure configured with at least one second recess configured to receive at least a second portion of the circumference of the mandrel with the wound scaffolding material;
at least one channel provided along a length of the second structure and arranged between the internal surface of the second recess and an external surface of the second structure,
wherein
the at least one first structure and the at least one second structure are configured for mated arrangement such that upon mating the circumference of the mandrel having the strip of scaffolding material wound there around is substantially encompassed by the first and second recesses,
the strip of scaffolding material wound around the circumference of the mandrel such that a first lengthwise edge of the strip is aligned immediately adjacent to a second lengthwise edge of the strip to form a tubular structure,
the two adjacently positioned lengthwise edges forming a lengthwise boundary, the lengthwise boundary being arranged adjacent the channel;
and
at least one needle arranged adjacent the channel and configured for insertion through the channel to tangentially puncture the tubular structure proximate to and along the lengthwise boundary from at least one side of the lengthwise boundary such that a portion of one or more fibers from the strip near at least one of the lengthwise edges traverses the lengthwise boundary and intertwines with one or more fibers from the strip near the other lengthwise edge thereby forming a seam.

US Pat. No. 10,363,123

DISTAL PROTECTION SYSTEMS AND METHODS WITH PRESSURE AND ULTRASOUND FEATURES

VOLCANO CORPORATION, San...

1. A system for providing embolic protection, the system comprising:a guidewire having a proximal end, a distal end, and a first pressure sensor disposed between the proximal end and the distal end of the guidewire;
a first sheath having a proximal end, a distal end, and a first sheath lumen, and a port between the proximal end and the distal end of the first sheath, wherein the port is in fluid communication with the first sheath lumen, the first sheath lumen configured to receive the guidewire;
a first distal protection filter attached to a distal portion of the first sheath;
a second sheath having a proximal end, a distal end and a second sheath lumen, the first sheath disposed within the second sheath lumen;
a second distal protection filter attached to a distal portion of the second sheath; and
an outer sheath disposed over both the first sheath and the second sheath,
whereupon being in a pre-deployed configuration, the first pressure sensor is axially disposed proximally of the first distal protection filter and the second distal protection filter, and whereupon being in a deployed configuration, the first pressure sensor is axially disposed between the first distal protection filter and the second distal protection filter and axially aligned with the port.

US Pat. No. 10,363,122

COMPOSITE MATERIAL FOR MEDICAL DEVICES AND METHOD OF MANUFACTURING THE SAME

TERUMO KABUSHIKI KAISHA, ...

1. A medical device comprising:one of a stent, a guide wire, an embolization coil, an inferior vena cava filter, and an orthodontics wire made of a composite material comprising a superelastic shape memory alloy matrix in which a metal oxide is dispersed;
wherein the superelastic shape memory alloy matrix is a sintered body made from a superelastic shape memory alloy powder, and the metal oxide is metal oxide particles dispersed in the superelastic shape memory alloy powder in an amount from 0.10% by volume to 0.5% by volume, and wherein the metal oxide particles are any one of 0.15% by volume to 0.5% by volume of TiO2 and 0.10% by volume to 0.2% by volume of Al2O3; and
wherein the superelastic shape memory alloy powder is a TiNi-based alloy powder.

US Pat. No. 10,363,121

KIT FOR MEASURING VERTICAL DIMENSION FOR DENTAL RESTORATION

King Saud University, Ri...

1. A kit for measuring vertical dimension for dental restoration, the kit consisting of:a base consisting of:
a planar member having first and second longitudinally opposed ends, transversely opposed side edges and opposed upper and lower surfaces, the upper surface having a plurality of longitudinally extending parallel grooves defined therein; and
first and second legs extending from the first and second longitudinally opposed ends of the planar member and projecting downward from the lower surface, the first and second legs defining a gap therebetween; and
a plurality of measurement sheets, each of the measurement sheets consisting of opposed upper and lower surfaces and a plurality of longitudinally extending ribs projecting from the lower surface of the sheet and a plurality of longitudinally extending grooves defined in the upper surface of the sheet, each of the plurality of ribs projecting from the sheet being dimensioned and configured for alternately seating in the corresponding groove defined in the upper surface of the base and the upper surface of the measurement sheets in order to interchangeably stack a variable number of the measurement sheets on the upper surface of the base, each of the plurality of measurement sheets having an equal thickness and being dimensioned and configured to extend coextensively with the entire upper surface of the base from end to end and side edge to side edge,
whereby the base is adapted for removable placement about at least one tooth of a patient in need of dental restoration such that the at least one tooth is positioned in the gap between the first and second legs, at least one coronal face of the at least one tooth being positioned below the lower surface of the planar member, so that the vertical dimension needed to compensate for worn teeth may be estimated by stacking the measurement sheets on the base to a height desired for the dental restoration.

US Pat. No. 10,363,120

APPARATUS AND METHODS FOR CLEANING TEETH AND ROOT CANALS

SONENDO, INC., Laguna Hi...

1. An apparatus for treating a tooth, the apparatus comprising:a chamber having an access port which places the chamber in fluid communication with a treatment region of the tooth when the chamber is coupled to the tooth, the access port having a central axis;
a fluid motion generator being arranged to generate rotational fluid motion in the chamber; and
a suction port having a distal-most plane exposed to the chamber on a side of the chamber opposite of the access port, and being disposed relative to the access port such that the central axis of the access port passes through the suction port.

US Pat. No. 10,363,119

DENTAL PROSTHESIS MANUFACTURING AIDS

Geodigm Corporation, Cha...

1. A jig for aiding in manufacturing a dental prosthesis to be mounted to a preparation site having at least a first adjacent dental structure within a mouth of a patient, the jig comprising:(a) a tooth preparation die including a first keying arrangement and a tapered top surface, wherein the first keying arrangement projects downwardly opposite the tapered top surface;
(b) a base including a seating region having a second keying arrangement that is structurally configured to fit with the first keying arrangement of the tooth preparation die such that the base is structurally configured to securely hold the dental prosthesis, the tooth preparation die representing the preparation site;
(c) a first side member configured to mount to a first side of the base, the first side member having a surface representing a side of the first adjacent dental structure within a mouth of a patient, wherein the first side member represents only a portion of the first adjacent dental structure within a mouth of a patient;
(d) a second side member configured to mount to a second side of the base; and
(e) a cover member configured to mount above the base.

US Pat. No. 10,363,118

METHODS AND SYSTEMS FOR GENERATING COLOR IMAGES

Align Technology, Inc., ...

1. A system for generating focused color image data of an object, the system comprising:a polychromatic light source that produces light comprising a first range of wavelengths, a second range of wavelengths, and a third range of wavelengths;
an optics system optically coupled to the polychromatic light source and operable to focus each of the first, second, and third ranges of wavelengths to a corresponding plurality of respective focal lengths;
a detector configured to collect color intensity data for each of the first, second, and third ranges of wavelengths at each corresponding plurality of respective focal lengths, the detector comprising first pixels sensitive to the first range of wavelength, second pixels sensitive to the second range of wavelengths, and third pixels sensitive to the third range of wavelengths; and
a processor configured to, for a location in the color intensity data:
determine, for each of the first, second, and third ranges of wavelengths, a focal length for which the respective range of wavelengths is focused relative to an object at the location in the color intensity data; and
combine the color intensity data for each of the first, second, and third ranges of wavelengths at the determined focal length, thereby generating focused color image data for the location in the color intensity data.

US Pat. No. 10,363,117

OVERLOAD FAILURE REDUCING DENTAL IMPLANTS

Board of Supervisors of L...

1. A dental implant comprising:a base;
a central shaft having an external tooth attachment portion adjacent a first end thereof, for engagement with a dental prostheses, and a strut portion, located adjacent a second end of the central shaft, supporting a shock absorber;
the shock absorber coupling the second end of the central shaft to the base and allowing limited movement between and spacing the base and the central shaft;
the shock absorber including a plurality of arcuate flex struts;
wherein a first end of each of the plurality of flex struts are directly attached to the central shaft and a second end of each of the plurality of flex struts are directly attached to the base; and
each one of the arcuate flex struts initially projects toward the second end of the central shaft before bending back toward the first end of the central shaft and then directly attaching to the base.

US Pat. No. 10,363,116

DIRECT FABRICATION OF POWER ARMS

Align Technology, Inc., ...

1. An appliance for placement on teeth of a patient, the appliance comprising:a plurality of power arms comprising a first power arm having a first connection point for connecting to a shell or tooth and a second power arm having a second connection point for connecting to a shell or tooth;
a connecting structure coupled to the first and second power arms to apply a first force to each of the first and second power arms; and
a counter-force connector coupled to the first power arm and extending toward the second power arm to apply a second force to each of the first and second power arms opposing the first force when engaging the second power arm,
wherein the connecting structure and the counter-force connector are coupled to the first power arm at respective locations separate from the first connection point, the connecting structure is coupled to the second power arm at a location separate from the second connection point, and the counter-force connector, when engaging the second power arm, contacts the second power arm at a location separate from the second connection point.

US Pat. No. 10,363,115

METHOD OF USING AN ENDENTULOUS SURGICAL GUIDE

IBUR, LLC, Troy, MI (US)...

1. A method comprising:receiving a digitally stored scan of a preoperative dental model including preoperative scan coordinates of at least a subset of at least one of a tomography of an oral structure of a patient, a topography of the oral structure, a dental impression of the oral structure, and a removable prosthesis of the patient as applied to the oral structure;
designing digitally a guide appliance with design coordinates using the preoperative dental model, the guide appliance comprising at least one opening configured to provide a view of a surgical site on the oral structure;
storing the design coordinates of the guide appliance as part of the preoperative dental model;
receiving a digitally stored postoperative scan including postoperative scan coordinates of at least a subset of a physical representation of the guide appliance manufactured using the design coordinates positioned on the oral structure and at least a portion of at least one of (i) an installed implant installed at the surgical site and (ii) an implant component associated with the installed implant, thereby locating the at least one implant in the postoperative scan;
superimposing the postoperative scan coordinates onto the preoperative dental model represented by the preoperative scan coordinates; and
aligning common coordinates of at least the guide appliance stored as part of the preoperative dental model and the postoperative scan, thereby forming a postoperative dental model including the location of the at least one implant.

US Pat. No. 10,363,114

AIMING AND STATUS INDICATOR SYSTEM FOR SURGICAL LIGHTHEADS AND CAMERAS

American Sterilizer Compa...

1. A lighting system, comprising:a support assembly;
a control unit for controlling operation of the lighting system; and
an accessory device mounted to the support assembly, the accessory device having an aiming and status indicator system comprising a plurality of marker lights mounted to the accessory device, each marker light providing a respective marker indicator beam aimed onto a work area to provide a respective marker indicator pattern on the work area, wherein the marker indicator patterns simultaneously indicate: (i) a geometric center that corresponds to a boresight of the accessory device for aiming the accessory device; and (ii) an operating condition.

US Pat. No. 10,363,113

ADJUSTABLE CONTAINMENT SHIELD

1. An adjustable containment shield operable to mount on an output housing of a surgical instrument, the containment shield comprising:a substantially transparent body including:
a distal face;
a proximal face opposite the distal face;
a generally consistent thickness defined between the distal face and the proximal face such that the body is pliable and resilient;
a mounting hole defined in the body and operable to engage the output housing of the surgical instrument;
a plurality of folds configured to allow the containment shield to move from a retracted position to an expanded position;
the body further comprises an outer edge and a plurality of facets defined on the proximal face, each facet bounded by respective folds and the outer edge;
at least one facet is configured to pivot relative to the mounting hole such that the containment shield moves from the retracted position to the expanded position; and
when mounted on the output housing of the surgical instrument, the distal face is at an acute angle with respect to a longitudinal axis through the mounting hole and facing toward a patient engagement end of the surgical instrument while the proximal face is at an obtuse angle with respect to the longitudinal axis and facing toward a housing side of the surgical instrument.

US Pat. No. 10,363,112

SKIN TEAR KIT, INSTRUCTIONAL LABELING SYSTEM, AND METHODS THEREFOR

Medline Industries, Inc.,...

1. A medical assembly, comprising:a package comprising a housing and a peelable lid having a major face; and
one or more medical implements for treating a wound, arranged in a stacked configuration within the package;
the peelable lid comprising:
an identification of a wound type the one or more medical implements are designed to treat;
a description of the wound type; and
printed instructions defining one or more steps instructing when to use each medical implement within the package to treat the wound.

US Pat. No. 10,363,111

PHACOEMULSIFICATION SURGICAL MULTI-USE PACK USAGE TRACKER SYSTEM

1. A reusable cassette sensing apparatus, configured to be part of a surgical device, comprising:a film configured to indicate a maximum number of uses of the surgical device;
a tracking system comprising an implement, at least one sensor and a processor, wherein the implement is configured to irreversibly modify the film, and wherein the at least one sensor is configured to sense the maximum number of uses from the film, and, prior to a use of the surgical device, the processor is configured to determine if the maximum number of uses has been reached based at least on a number of irreversible modifications of the film, by the implement.

US Pat. No. 10,363,110

SURGICAL DRAPE WITH SEPARABLE ELEMENTS

Creative Surgical Solutio...

1. A surgical drape to temporarily cover a surgical table while maintaining a sterile field during a sterile surgical procedure to lower a risk of infection, comprising:a drape having a generally rectangular shape and an area defined by a predetermined length and a predetermined width, the drape having an upper portion and an under-table wrapping element;
a selectively separable portion on the upper portion and extending an entirety of the predetermined length of the drape, said selectively separable portion having a single pleat extending the entirety of the predetermined length of the drape, said selectively separable portion having a single longitudinal serrated tear line disposed below the single pleat, said selectively separable portion adapted to be positioned on top of the surgical table to maintain a sterile field;
said selectively separable portion having a closed position and an unclosed position, wherein the single pleat covers said single longitudinal serrated tear line when in said closed position; and wherein the single pleat is adapted to be opened when said selectively separable portion is in said unclosed position to allow said drape to be separated along said single longitudinal serrated tear line, so that longitudinal effaced lateral sides of said drape separate and fall away from respective sides of the surgical table in a sterile fashion.

US Pat. No. 10,363,109

SIGNAL CONNECTOR FOR STERILE BARRIER BETWEEN SURGICAL INSTRUMENT AND TELEOPERATED ACTUATOR

Intuitive Surgical Operat...

1. An instrument sterile drape comprising:a plastic sheet;
an instrument sterile adapter (ISA) coupled to the plastic sheet, the ISA including a bottom plate located on a first side of the plastic sheet and a top plate located on a second side of the plastic sheet and joined to the bottom plate, the bottom plate including a passage that allows a flux connection of an instrument carriage to pass through the plastic sheet and the bottom plate to be placed adjacent to the top plate, the top plate including a signal transmission area that will be adjacent to an upper surface of the flux connection of the instrument carriage; and
a flux connector that closes an opening in the signal transmission area of the top plate and provides a path for one of an electrical signal and an optical signal.

US Pat. No. 10,363,108

SURGICAL DRAPE WITH SEPARABLE ELEMENTS

Creative Surgical Solutio...

1. A surgical drape to temporarily cover a surgical table while maintaining a sterile field during a surgical procedure to lower a risk of infection, comprising:a drape having a generally rectangular shape and an area defined by a predetermined length and a predetermined width, the drape having an upper portion and an under-table wrapping element;
a selectively separable portion on the upper portion and extending along a substantial portion of the predetermined length of the drape, the selectively separable portion having a pleat extending the entirety of the predetermined length of the drape, the selectively separable portion having a single longitudinal score line disposed below the pleat, said selectively separable portion adapted to be positioned on top of the surgical table;
said pleat having a closed position and an unclosed position wherein said pleat covers said single longitudinal score line when in said closed position; and wherein said pleat is adapted to be opened when said pleat is in said unclosed position to allow said drape to be separated along said single longitudinal score line, so that longitudinal effaced lateral sides of said drape separate and fall away from respective sides of the surgical table in a sterile fashion;
wherein the single longitudinal score line comprises a serration; and
wherein at least a portion of the drape is substantially transmissive to a radiographic signal.

US Pat. No. 10,363,107

WIRELESS FORCE SENSOR ON A DISTAL PORTION OF A SURGICAL INSTRUMENT AND METHOD

Intuitive Surgical Operat...

1. A surgical instrument comprising:a shaft having an exterior surface:
a wrist joint coupled to the shaft; and
a surgical end effector mounted distal to said wrist joint, the surgical instrument comprising a jaw portion,
the jaw portion having an external non-contact surface bounding a contact surface, wherein a force sensor is mounted on the non-contact external surface, the force sensor comprising:
a wireless package comprising a surface acoustic wave strain sensor and a folded antenna, the folded antenna being electrically coupled to the surface acoustic wave strain sensor.

US Pat. No. 10,363,106

SURGICAL ROBOT FOR STEREOTACTIC SURGERY AND METHOD FOR CONTROLLING STEREOTACTIC SURGERY ROBOT

KOH YOUNG TECHNOLOGY INC....

1. A stereotactic surgery robot comprising:a rotating unit configured to have a surgical instrument that is able to be attached thereto, and configured to rotate the surgical instrument on at least one of two rotational axes according to an entry posture of the surgical instrument;
a moving unit configured to move the rotating unit in a direction of at least one of three linear axes according to a position of a surgical target; and
a surgical portion support unit configured to be connected to the moving unit, and configured to be detachable with respect to an operating table,
wherein the moving unit moves the rotating unit such that an intersection point of the two rotational axes matches the surgical target, wherein the moving unit comprises: wherein the moving unit comprises: a first direction driving unit configured to move along a first linear axial direction; a second direction driving unit configured to move along a second linear axial direction while being connected to the first direction driving unit; and a third direction driving unit configured to move along a third linear axial direction while being connected to the second direction driving unit, and wherein the rotating unit comprises: a first rotational driving unit configured to rotate on a first rotational axis of the at least two rotational axes, while one end of the first rotational driving unit is connected to the third direction driving unit; and a second rotational driving unit configured to rotate on a second rotational axis of the at least two rotational axes, while one end of the second rotational driving unit is connected to the other end of the first rotational driving unit and while the surgical instrument is attached to the other end of the second rotational driving unit.

US Pat. No. 10,363,105

VIBRATION ACTUATOR SUITABLE FOR USE IN MAGNETIC FIELD ENVIRONMENT AND MEDICAL SYSTEM

Canon Kabushiki Kaisha, ...

1. A vibration actuator in which a vibration element and a driven element are in contact with each other, with relative movement being effected between the driven element and the vibration element,the vibration element comprising:
an elastic body of which a main ingredient comprises a material which is electrically insulating, dielectric, or semi-conductive, said elastic body being in contact with the driven element; and
an electromechanical energy conversion element that is joined to said elastic body, said electromechanical energy conversion element comprising:
a piezoelectric body;
a first electrode that is provided on a surface of said piezoelectric body, through which surface said piezoelectric body is joined to said elastic body, said first electrode having a first gap to form an open loop structure;
at least two second electrodes that are provided in a manner opposed to said first electrode via said piezoelectric body;
at least one third electrode that is provided in a manner opposed to said first electrode via said piezoelectric body; and
at least one conduction path that electrically connects said first electrode and said at least one third electrode,
wherein a second gap is formed between said at least two second electrodes, and
wherein when viewed in a direction along which the vibration element is pressed against the driven element, a width of the first gap is narrower than a width of the second gap.

US Pat. No. 10,363,104

INTERFACES FOR SURGICAL SYSTEMS

Covidien LP, Mansfield, ...

1. An interface for a surgical system, comprising:an instrument drive unit including:
a connection hub; and
at least one drive shaft rotatably supported in the connection hub, the at least one drive shaft extending between and having a first end configured for connection with a motor and a second end having an oblique end surface; and
a surgical instrument releasably connectable to the instrument drive unit, the surgical instrument including:
a connecting member; and
at least one driven shaft rotatably supported in the connecting member, the at least one driven shaft extending between and having a first end and a second end, the second end having an oblique end surface corresponding to the oblique end surface of the at least one drive shaft of the instrument drive unit,
wherein the oblique end surfaces are configured such that the oblique end surface of the at least one driven shaft of the surgical instrument is connectible with the oblique end surface of the at least one drive shaft of the instrument drive unit via a first connection pathway and a second connection pathway, the second connection pathway oriented transversely relative to the first connection pathway.

US Pat. No. 10,363,103

FLEXIBLE AND STEERABLE ELONGATE INSTRUMENTS WITH SHAPE CONTROL AND SUPPORT ELEMENTS

Auris Health, Inc., Redw...

1. A steerable elongate instrument, comprising:an elongate body, comprising:
a proximal portion;
a distal portion;
a first lumen extending through the proximal portion and the distal portion; and
multiple secondary lumens extending through the proximal portion and the distal portion;
multiple flex tubes disposed within the secondary lumens within the proximal portion of the elongate body, wherein a proximal portion of each flex tube is slideable into and out of the elongate body at a proximal end of the elongate body, wherein a distal end of each flex tube is fixedly coupled to a distal end of the proximal portion of the elongate body, and wherein, when the elongate body is placed in a bend such that a first side of the elongate body contracts and a second side of the elongate body stretches, one of the flex tubes located in the first side slides at least partially out of the secondary lumen in which it is disposed, and another of the flex tubes located in the second side slides at least partially into the secondary lumen in which it is disposed;
multiple pull wires, wherein each of the flex tubes has a different one of the pull wires disposed therein; and
a control unit positioned proximal to the elongate body,
wherein a distal portion of each of the pull wires is coupled to the distal portion of the elongate body, and wherein a proximal portion of each of the pull wires is operatively coupled to the control unit.

US Pat. No. 10,363,102

INTEGRATED SURGERY METHOD

MAKO Surgical Corp., For...

1. A method for conducting a medical procedure in an operating room, comprising:defining a predetermined operational plan comprising a plurality of positions of a procedure object over time;
assigning a desired time milestone within the procedure for each position of the object in the predetermined operational plan;
using a first camera-based 3-D motion sensor mounted in a known position and orientation in a global coordinate system of the operating room to generate signals related to a 3-D position of the procedure object in the operating room relative to the first camera-based 3-D motion sensor;
automatically monitoring progress of the medical procedure based at least in part upon one or more positions of the procedure object over time, the one or more positions based at least in part upon the signals from the first camera-based 3-D motion sensor;
comparing the one or more positions of the procedure object over time with the desired time milestone within the procedure for each position of the object in the predetermined operational plan;
recording data relating to an actual time for each position of the object in the predetermined operational plan compared with the desired time milestone; and
using the data during or after the procedure to provide a recommendation for a change to a future predetermined operational plan.

US Pat. No. 10,363,101

OPTICAL SHAPE SENSING SYSTEM, MEDICAL APPARATUS AND METHOD FOR OPTICAL SHAPE SENSING

KONINKLIJKE PHILIPS N.V.,...

1. A system for sensing a shape of a medical device, comprising:an input polarization controller for setting an input polarization state of an input light signal,
at least one interferometer unit for dividing input light signal into a medical device signal and a reference signal, guiding said device signal to be scattered within an optical fiber inserted into said medical device and coupling said scattered device signal with said reference signal to form an output light signal, and
at least one measurement branch comprising an output polarization controller arrangement for setting an output polarization state of said output light signal, a polarizing beam splitter for splitting said output light signal into two signal portions, each being in a corresponding one of two signal portion polarization states, and a detector arrangement, comprising two detectors, each for detecting a corresponding one of said two signal portions, said input polarization controller being configured to set two pairs of input polarization states, or said output polarization controller arrangement is configured to set two output polarization states each for enabling a corresponding one of two pairs of signal portion polarization states, wherein: each pair of input or signal portion polarization states are representable by a corresponding one of two axes in a Poincaré sphere different from each other; and said input polarization controller is configured to set a reference polarization state of said reference signal, said reference polarization state corresponding to an eigen polarization mode of an optical fiber guiding said reference signal.

US Pat. No. 10,363,100

SYSTEMS AND METHODS FOR PATIENT-SPECIFIC MODELING OF THE HEART FOR PREDICTION OF TARGETS FOR CATHETER ABLATION OF VENTRICULAR TACHYCARDIA IN PATIENTS WITH IMPLANTABLE CARDIOVERTER DEFIBRILLATORS

The Johns Hopkins Univers...

1. A computer implemented method of non-invasively simulating a subject-specific cardiac procedure, comprising:receiving three-dimensional imaging data of a subject's heart, the subject having an ICD, wherein said ICD causes an imaging artifact in said three-dimensional imaging data of said subject's heart, said three-dimensional imaging data including regions that are free of said artifact and regions that are affected by said artifact;
segmenting said regions of said three-dimensional imaging data that are free of said artifact into a plurality of normal tissue regions and remodeled tissue regions for said subject;
extrapolating from said regions of said three-dimensional imaging data that are free of said artifact to provide extrapolated three-dimensional imaging data corresponding to said regions that are affected by said artifact; and
simulating at least one of electrophysiological or electromechanical activity of at least a portion of said subject's heart using said segmented and extrapolated three-dimensional imaging data, said simulating including providing a preselected alteration of at least one of electrophysiological or electromechanical behavior of said subject's heart for a target of said subject-specific cardiac ablation procedure.

US Pat. No. 10,363,099

HYBRID CATHETER FOR VASCULAR INTERVENTION

1. An atherectomy catheter for removing an undesired tissue from a vessel wall, said catheter having a tip section comprising:a wall forming a lumen, wherein a distal extremity of said wall form an end opening;
a tissue debulking element configured to debulk at least part of said undesired tissue; and
a drug delivering element configured to administer a drug to the undesired tissue or the vessel wall; wherein the drug delivering element is constructed and positioned to abut the undesired tissue or the vessel wall when applying the drug and wherein the drug delivering element comprises a roller configured to roll over the tissue, thereby delivering the drug to the tissue.

US Pat. No. 10,363,098

MICROWAVE ENERGY-DELIVERY DEVICE AND SYSTEM

COVIDIEN LP, Mansfield, ...

1. An ablation system, comprising:a microwave ablation device including:
a feedline including an outer conductor;
a balun operably coupled to the outer conductor of the feedline; and
a temperature sensor directly coupled to the feedline and disposed in proximity to the balun to sense a temperature of a portion of the feedline;
a fluid delivery system configured to operably couple to the microwave ablation device and provide a fluid to the microwave ablation device; and
an energy source configured to operably couple to the microwave ablation device and provide microwave energy to the microwave ablation device.

US Pat. No. 10,363,097

ABLATION SYSTEM HAVING MULTIPLE ENERGY SOURCES

COVIDEN LP, Mansfield, M...

1. An ablation system comprising:a generator including a first energy source configured to supply a first type of energy to tissue, a second energy source configured to supply a second type of energy to tissue different from the first type of energy, a power source configured to power the first and second energy sources, and a user interface;
a switch coupled to the generator; and
a cable coupled to the generator, the cable configured to transmit the first type of energy to tissue and to transmit the second type of energy to tissue,
wherein the switch allows the first type of energy and the second type of energy to flow through the cable simultaneously.

US Pat. No. 10,363,096

METHOD FOR CONSTRUCTING A DIPOLE ANTENNA

COVIDIEN LP, Mansfield, ...

1. A method of constructing an antenna, comprising:providing a mold including a cavity;
placing an antenna element within the cavity, the antenna element including a proximal portion and a distal portion separated from the proximal portion; and
injecting a material into the cavity to adhere a ceramic layer of the distal portion of the antenna element to the proximal portion of the antenna element.

US Pat. No. 10,363,095

MICROWAVE THERMOMETRY FOR MICROWAVE ABLATION SYSTEMS

COVIDIEN LP, Mansfield, ...

1. A microwave ablation system comprising:a microwave applicator including an antenna configured to deliver microwave energy to ablate tissue;
a microwave generator coupled to the microwave applicator via a transmission network and configured to generate a microwave signal and transmit the microwave signal to the antenna;
a radiometer configured to measure a noise temperature from a signal propagating through the transmission network;
a controller configured to turn off the microwave signal generated by the microwave generator for a predetermined period and to control the radiometer to measure the noise temperature during the predetermined period; and
at a first thermocouple configured to measure a first temperature of a cooling fluid and a second thermocouple configured to measure a second temperature of the cooling fluid, the radiometer configured to measure the noise temperature when the first temperature is substantially the same as the second temperature.

US Pat. No. 10,363,093

SYSTEM AND METHODS OF TREATMENT USING ELECTROMAGNETIC ILLUMINATION

Old Dominion University R...

1. A method for treatment of patient tissue, the method comprising:generating a first radiation and a second radiation, the first radiation configured to cause a distribution of temperatures in the patient tissue, and the second radiation configured to produce a distribution of electric fields in the patient tissue configured to affect cell functions in patient tissue non-thermally; and
directing the first radiation and the second radiation to the patient tissue so that the relative position of a peak of the distribution of temperatures and a peak of the distribution of electric fields provides a pre-determined target combination of temperatures and electric fields in a target volume of the patient tissue.

US Pat. No. 10,363,074

DYNAMIC AXIAL NAIL FOR INTRAMEDULLARY TREATMENT OF LONG BONE FRACTURES

1. An intramedullary nail configured for insertion across a fracture site of a bone, the fracture site comprising first and second portions, comprising:a distal portion having a distal end having a first diameter and a proximal end having a second diameter smaller than the first diameter, the distal end also having a first land formed at an intersection of the proximal and distal ends of the distal portion;
a proximal portion having a proximal end and distal end, the distal end of the proximal portion configured to moveably receive the proximal end of the distal portion, the first land, and a portion of the distal end of the distal portion, the distal end of the proximal portion having a first bore having a first diameter extending from the distal end of the proximal portion to a second land formed by an intersection of the first bore with a second bore having a second diameter less than the first diameter of the first bore;
a space fined by the first land and second land;
a reversibly compressible bias member disposed in the space for biasing the distal and proximal portions apart along a longitudinal axis; and
an adjusting assembly configured to engage the distal and proximal portions such that actuation of the adjusting assembly alters a longitudinal length of the space so that an overall length of the intramedullary nail results in separation of the first and second portions of the fractured bone when the intramedullary nail is disposed across the fracture site.

US Pat. No. 10,363,019

BIOPSY NEEDLE, BIOPSY NEEDLE ASSEMBLY, AND METHODS FOR BIOPSY

Secretary, Department of ...

1. A biopsy needle to pierce a biopsy region and extract a tissue sample, the biopsy needle comprising:a primary needle section formed as a hollow tube, wherein the primary needle section comprises a first end and a second end; and
a converging section arcuately converging from a wall of the hollow tube of the first end to form a piercing tip, wherein the converging section comprises a first cutting edge and a second cutting edge that converge arcuately for piercing the biopsy region, and wherein the converging section comprises an opening on a lateral wall extending from the wall of the primary needle section to the piercing tip, the opening having a third cutting edge for cutting the tissue sample under application of a negative pressure,
wherein the opening is inclined at a predetermined angle ? ranging from an angle greater than 0 degrees to an angle of 15 degrees to a central axis of the biopsy needle, and wherein the first cutting edge is inclined to a transverse axis of the biopsy needle at a predetermined angle ? ranging from an angle greater than 0 degrees to an angle of 30 degrees, and the second edge is inclined to the transverse axis of the biopsy needle at a predetermined angle ? ranging from an angle greater than 0 degrees to an angle of 30 degrees, and
wherein a surface of at least one of the first cutting edge, the second cutting edge, and the third cutting edge is curved, and wherein the converging section includes a curvature defined by a radius R, the radius R being in a range of 5-15 times of an outer diameter of the primary needle section to provide an in-plane bend that spans across the opening, the in-plane bend extending below the opening from the piercing tip to the wall of the primary needle section, whereby the piercing tip is positioned above the central axis of the biopsy needle.

US Pat. No. 10,362,998

SENSOR-BASED DETECTION OF CHANGES IN HEALTH AND VENTILATION THRESHOLD

SAMSUNG ELECTRONICS CO., ...

1. An apparatus for monitoring health status of a user, comprising:a photoplethysmography sensor adapted to generate photoplethysmography sensor data;
a memory adapted to store a baseline biological marker for the user, wherein the baseline biological marker includes respiratory rhythm, heart rate, and a rating of perceived exertion corresponding to an occurrence of ventilation threshold;
a processor coupled to the memory and the sensor, wherein the processor is adapted to:
in response to receiving a user input specifying that a maximum rating of perceived exertion for the user is reached indicating a subsequent occurrence of ventilation threshold, determine a biological marker from the photoplethysmography sensor data, wherein the biological marker includes respiratory rhythm and heart rate corresponding to the subsequent occurrence of ventilation threshold;
compare the biological marker determined from the photoplethysmography sensor data with the baseline biological marker stored in the memory; and
in response to detecting a difference between the biological marker and the baseline biological marker, provide a notification indicating a change in health status.

US Pat. No. 10,362,990

PASSIVE CATHETER IDENTIFICATION AND SELF-CONFIGURATION SYSTEM

General Electric Company,...

1. A catheter identification system for providing information about one or more attributes of a catheter connectable to an electrophysiology (EP) recording or mapping system, the identification system comprising:a) a catheter;
b) a resistor network operably connected to the catheter, the resistor network including at least one identification resistor and a return connected to the at least one identification resistor; and
c) an identification resistor measurement circuit operably connected to the catheter and configured to send an identification signal through the at least one resistor in the resistor network to retrieve an altered identification signal from the identification resistor, where the altered identification signal provides information on an attribute of the catheter.

US Pat. No. 10,362,960

MULTI POINT TREATMENT PROBES AND METHODS OF USING THEREOF

Renal Dynamics Ltd., Roa...

1. A system of intrabody treatment, comprising:a multi point probe transported by a catheter to a lumen of a body of a treated patient, the multi point probe having at least two transmission points; and
a processor configured to:
select a transmission pattern including for each of the at least two transmission points, a respective signal of a plurality of radio frequency transmission signals, said transmission pattern forms at least one interaction between the respective signals from the at least two transmission points, the at least one interaction defines at least one hot spot at the treatment location; and
control delivery of the respective signals from the transmission points;wherein the processor determines a timing for each of said respective signals.

US Pat. No. 10,362,941

METHOD AND APPARATUS FOR PERFORMING REGISTRATION OF MEDICAL IMAGES

Samsung Electronics Co., ...

1. A method of performing registration of medical images, comprising:mapping, by a processor, a virtual coordinate system used by a first medical apparatus and a virtual coordinate system used by a second medical apparatus to each other, wherein a real-time medical image is captured in a first position of a patient by the first medical apparatus and a three-dimensional (3D) medical image is previously captured in a second position of the patient by the second medical apparatus;
detecting, by the processor, a position of a probe of the first medical apparatus in the virtual coordinate system used by the second medical apparatus, based on a result of the mapping;
determining, by the processor, a volume image, corresponding to the detected position of the probe, from the previously captured 3D medical image;
selecting a reference cross-section from the determined volume image using the detected position of the probe;
estimating a relative movement range of a scanning plane of the probe from the reference cross-section according to a patient's physical movement with the probe being static relative to the virtual coordinate system used by the second medical apparatus and by using previously stored information about a range in which an organ can be moved by the patient's physical movement;
selecting neighboring cross-sections that exist in the estimated relative movement range of the scanning plane;
reconstructing a volume image by accumulating the reference cross-section and the neighboring cross-sections; and
extracting, by the processor, from the reconstructed volume image a cross-sectional image corresponding to the real-time medical image, wherein the cross-sectional image changes according to the patient's physical movement, and
wherein the determined volume image comprises a volume image smaller than the previously captured 3D medical image and has a dimension determined by the estimated relative movement range of the scanning plane of the probe from the reference cross-section.

US Pat. No. 10,362,917

CLEANING ROBOT

SAMSUNG ELECTRONICS CO., ...

1. A cleaning robot comprising a main body and a drive unit to move the main body, further comprising:an input unit to input a motion instruction for the cleaning robot;
a tilt sensor to measure an inclination of the cleaning robot moving in accordance with the input motion instruction; and
a controller to determine a stuck state of the cleaning robot by using an angle value obtained by measuring an angle the cleaning robot has moved based on sensor information of the tilt sensor.

US Pat. No. 10,362,914

CLEANER AND CONTROL METHOD THEREOF

SAMSUNG ELECTRONICS CO., ...

11. A cleaner comprising:a power supply;
a suction unit including a main suction port;
a driving unit including a motor including a rotor and a stator;
a sensing unit including a hall sensor to detect a position of the rotor; and
a controller configured to control the power supply to supply predetermined rotor rearrangement power, which is power supplied for rearrangement of the position of the rotor, to the motor for a predetermined time period until cogging torque of the motor reaches a maximum, ending the supply of the predetermined rotor rearrangement power to the motor when the cogging torque of the motor reaches the maximum, supply start-up power to the motor according to the position of the rotor detected by the hall sensor, and supply stopping power to the motor after the cogging torque of the motor reaches the maximum,
wherein the stopping power is supplied in an opposite direction to that of the rotor rearrangement power, or the stopping power is a zero voltage, and
wherein the rotor rearrangement power is supplied such that torque that is generated by the rotor rearrangement power is greater than cogging torque of the motor.

US Pat. No. 10,362,912

VACUUM CLEANER

LG ELECTRONICS INC., Seo...

1. A vacuum cleaner comprising:a cleaner body; and
a dust collector received in the cleaner body, wherein the dust collector includes:
an external case having a first dust storage space therein;
an upper cover installed to cover an upper opening of the external case;
a lower cover coupled to a lower opening of the external case;
a first cyclone installed within the external case, having a mesh filter to filter first contaminants from air sucked from outside the dust collector, and configured to introduce the filtered air inside the first cyclone;
a second cyclone provided in the first cyclone and configured to separate second contaminants from the filtered air introduced inside of the first cyclone;
one or more cleaning extensions configured to remove a portion of the first contaminants clinging on an outer circumferential surface of the mesh filter; and
a rotary case coupled to the mesh filter and relatively rotating the mesh filter with respect to the cleaning extensions.

US Pat. No. 10,362,877

CUSHION WITH SUPPORTING FRAME FOR UPHOLSTERED FURNITURE

EDRA S.P.A., Perignano d...

1. A cushion for upholstered furniture for leaning or sitting such as beds, sofas or armchairs, including a cushion element, constituted by an upholstery of soft material stuffed in a flabby covering, the cushion element being configured so that two opposite main sides are defined that are peripherally joined by connection sides, comprising:an elongated fixed frame arranged so as to define in the cushion element an upper section located above the fixed frame;
at least two movable frames housed within the same cushion element in correspondence of the upper section, with each of the movable frames being hinged, independently from the other, to the fixed frame according to at least one hinge axis substantially parallel to a direction of elongation of the fixed frame, and arranged to take different positions, each of which is provided to determine a desired orientation of at least one portion of the upper section of the cushion element;
movement control means associated with the hinge axes, adapted to determine an amount of deformation action needed to rotate the at least one movable frame, so as to maintain a stable position when a deformation action is applied that is lower than a certain predetermined amount; and
connecting members for connecting the cushion element to an external structure;
wherein the fixed frame extends horizontally at a vertically intermediate level of the cushion element so as to define a lower section of the cushion element located below the fixed frame, the lower section being devoid of rigid frame elements.

US Pat. No. 10,362,816

EXPANDABLE HEADBAND

1. An expandable headband comprising:an elongated, pleated, expandible cover having two opposing ends, a front edge and a rear edge;
means for securing the cover whereby the cover is adapted to rest atop a wearer's crown to form a headband;
an extendable support rod integral with the front edge of the cover that allows a wearer to grasp the front edge and expand the cover to form a visor;
an elongated channel on the front edge of said cover, said channel receiving said support rod;
a pair of buttons attached to said cover, each of said buttons having a central passageway aligned with said channel, a portion of said rod slidably received within each of said passageways to allow the rod to deploy and retract concomitant with expansion of the cover.

US Pat. No. 10,362,723

HAND-OPERATED SPREADER

1. A hand-operated spreader comprising:a base having a transmission mechanism with an operating arm and a rotating disk driven by the transmission mechanism;
an assembly member disposed above the rotating disk of the base, an open end provided on a side of the assembly member and configured for distributing, a limiting portion with a continuous curve provided on the open end, a feeding opening provided at a center portion of the assembly opposite engaging slots disposed on a circular sidewall corresponding to a container;
a feeding rudder rotatably mounted in the feeding opening of the assembly member, the feeding rudder having an inclined surface and a through aperture on the inclined surface, the feeding rudder further having a rotating handle extending from the open end of the assembly member and configured to move along the limiting portion with a plurality of predetermined positions;
an adjusting member rotatably mounted inside the circular sidewall of the feeding opening, the circular sidewall having a T-shaped limiting gap for limiting the adjusting member, the adjusting member further having a tapered casing with at least three holes inside the circular sidewall, opposing sides of the three holes provided with a mixing rod; a side of the adjusting member provided with a control handle extending from the limiting gap, a guiding slot disposed on the assembly member, the guiding slot having a slidable limiting bar for moving the control handle; and
a feeding cone fixed in the circular sidewall of the feeding opening and overlaying the tapered casing of the adjusting member and having at least three feeding apertures corresponding to the three holes of the tapered casing.
US Pat. No. 10,363,301

STABILIZED INFLUENZA HEMAGGLUTININ STEM REGION TRIMERS AND USES THEREOF

The United States of Amer...

1. A nanoparticle comprising a protein construct that comprises an HA protein domain and a linker sequence, wherein the HA protein domain comprises the sequence of an influenza hemagglutinin (HA) protein that lacks at least 95% of the head region amino acid sequence, and in place of the missing sequence comprises a linker sequence, wherein the linker sequence is less than 10 amino acids in length; and,wherein the HA protein comprises at least one alteration selected from the group consisting of:
a. deletion of the amino acid region corresponding to amino acids N403-W435 of SEQ ID NO:8; and,
b. substitution of at least one amino acid residue in a pair of amino acid residues, wherein the amino acid residues correspond to K1 and E53 of SEQ ID NO:149; and, wherein the strength of the bond between the amino acid pair in the folded, altered protein is greater than the strength of the bond between the amino acid pair in the folded, wild-type protein.
US Pat. No. 10,363,314

SPRAYABLE TOPICAL CARRIER AND COMPOSITION COMPRISING PHOSPHATIDYLCHOLINE

LIPIDOR AB, Stockholm (S...

1. Pharmaceutical or cosmetic carrier for topical administration, said carrier comprisingfrom 2%-40% by weight of phosphatidylcholine;
from 2%-25% by weight of monoglyceride;
from 2% to 30% by weight of fatty acid ester of C1-C3 alcohol; and
volatile solvent selected from the group consisting of:
ethanol; ethanol and C3-C4 alcohol; ethanol and volatile silicone oil; and ethanol, C3-C4 alcohol and volatile silicone oil.
US Pat. No. 10,364,350

VESICULAR SYSTEM AND USES THEREOF

AGENCY FOR SCIENCE, TECHN...

1. A process of forming a vesicle with an associated membrane protein, comprising:providing a vesicle having a circumferential membrane of an amphiphilic polymer, wherein the vesicle is a synthetic polymer vesicle and the amphiphilic polymer is a synthetic block copolymer, the amphiphilic polymer comprising a molecule with a non-polar moiety, wherein a portion of the non-polar moiety of the molecule is integrated into the circumferential membrane of the vesicle, wherein the molecule with the non-polar moiety is capable of coupling the vesicle to a surface via a covalent or non-covalent bond, the non-polar moiety being one of an aliphatic, an alicyclic, an aromatic and an arylaliphatic moiety,
wherein the non-polar moiety comprises a main chain of 3 to about 30 carbon atoms and 0 to about 12 heteroatoms selected from Si, O, S, N, and Se; and
contacting the vesicle with a cell-free expression system and a nucleic acid molecule encoding the associated membrane protein under conditions suitable for transcription and translation of the nucleic acid molecule such that the associated membrane protein is formed in situ and associated with the circumferential membrane of the amphiphilic polymer of the vesicle, wherein the associated membrane protein is an odorant receptor 5 protein, an alpha-hemolysin protein, or a claudin-2 protein,
wherein a portion of the associated membrane protein is integrated into the circumferential membrane of the amphiphilic polymer of the vesicle,
wherein the amphiphilic polymer is a diblock (A-B) or a triblock copolymer (A-B-A or A-B-C),
wherein the cell-free expression system is selected from the group consisting of eukaryotic cell-free expression system, prokaryotic cell-free expression system, and archaic cell-free expression system.
US Pat. No. 10,364,158

AMORPHOUS MESOPOROUS ALUMINA WITH HIGH CONNECTIVITY AND PRODUCTION METHOD THEREOF

IFP Energies Nouvelles, ...

1. A process for preparing amorphous mesoporous alumina, said process consisting of:a) a first alumina precipitation step, in an aqueous reaction medium, of at least one basic precursor selected from sodium aluminate, potassium aluminate, ammonia, sodium hydroxide and potassium hydroxide, and at least one acidic precursor selected from aluminum sulphate, aluminum chloride, aluminum nitrate, sulphuric acid, hydrochloric acid, and nitric acid, in which at least one of the basic or acidic precursor comprises aluminum, the relative flow rate of the acidic and basic precursors is chosen so as to obtain a pH of the reaction medium between 8.5 and 10.5, and the flow rate of the acidic and basic precursor or precursors containing aluminum is regulated so as to obtain a rate of progress between 40 and less than 100%, the rate of progress being defined as the proportion of alumina formed as Al2O3 equivalent during the first precipitation step with respect to the total amount of alumina formed at the end of a second precipitation step a?), the first precipitation step a) being carried out at a temperature between 10 and 40° C. and for a period between 2 minutes and 30 minutes, wherein the first precipitation step a) produces a suspension,
wherein the second precipitation step a?) is performed after the first precipitation step, and, between the first and second precipitation steps a) and a?) the suspension obtained at the end of first precipitation step a) is heated in an intermediate heating step carried out at a temperature between 20 and 90° C. and for a period of between 7 and 45 minutes, and
said second precipitation step a?) is performed on the suspension obtained at the end of the intermediate heating step by adding to the said suspension obtained at the end of the intermediate heating step at least one basic precursor selected from sodium aluminate, potassium aluminate, ammonia, sodium hydroxide and potassium hydroxide and at least one acidic precursor selected from aluminum sulphate, aluminum chloride, aluminum nitrate, sulphuric acid, hydrochloric acid, and nitric acid, in which at least one of the basic or acidic precursors contains aluminum, the relative flow rate of the acidic and basic precursors is chosen so as to obtain a pH of the reaction medium between 8.5 and 10.5 and the flow rate of the acidic and basic precursor or precursors containing aluminum is regulated so as to obtain a rate of progress of second precipitation step a?) between 0 and 60%, the rate of progress of second precipitation step a?) being defined as the proportion of alumina formed as Al2O3 equivalent during the second precipitation step a?) with respect to the total amount of alumina formed at the end of second precipitation step a?), second precipitation step a?) being carried out at a temperature between 40 and 90° C., and for a period of between 2 minutes and 50 minutes,
b) a heat treatment step wherein the suspension obtained at the end of second precipitation step a?) is heated at a temperature between 50 and 200° C. for a period between 30 minutes and 5 hours,
c) a filtration step wherein the suspension obtained at the end of the heat treatment step b) is filtered and an alumina gel is obtained, followed by at least one washing step of the obtained gel,
d) a drying step wherein the alumina gel obtained at the end of the step c) is dried to obtain a powder,
e) a molding step wherein the powder obtained at the end of the step d) is molded to obtain crude material, and
f) a heat treatment step wherein the crude material obtained at the end of the step e) is heated at a temperature between 500 and 1000° C., in the presence or otherwise of a stream of air containing up to 60% by volume of water.
US Pat. No. 10,364,417

INCREASED ALCOHOL TOLERANCE USING THE PNTAB GENE

The United States of Amer...

1. A transformed microorganism,wherein the transformed microorganism contains an alcohol tolerance gene,
wherein the transformed microorganism has a higher alcohol tolerance as compared to a non-transformed microorganism, and
wherein the alcohol tolerance gene is one of pntAB, pntA, and pntB,
wherein each of pntA, pntB, and pntAB is a transhydrogenase gene,
wherein the alcohol tolerance gene comprises a nucleotide sequence having at least 75% similarity to one of SEQ ID NO: 17, SEQ ID NO: 18, SEQ ID NO: 19, SEQ ID NO: 20, SEQ ID NO: 21, and SEQ ID NO: 22, and
wherein the microorganism expresses at least one alcohol tolerance protein, the alcohol tolerance protein being at least one of PntA and PntB.
US Pat. No. 10,364,425

RECOMBINANT OR TRANSGENIC FACTOR VII COMPOSITION, EACH FACTOR VII MOLECULE HAVING TWO N-GLYCOSYLATION SITES WITH DEFINED GLYCAN UNITS

LABORATOIRE FRANCAIS DU F...

1. A composition comprising recombinant Factor VII (FVII), produced by a transgenic female rabbit,wherein each molecule of FVII of the composition exhibits glycan moieties and two N-glycosylation sites,
wherein among all the molecules of FVII of the composition, the proportion of Gal?1,3Gal glycan moieties is between 0 and 4%,
wherein the molecules of FVII of the composition do not comprise sialic acid bound in ?2-3 links,
wherein among all the glycan moieties bound to N-glycosylation sites of the FVII of the composition, more than 50% of the glycan moieties are biantennary, monosialylated, glycan moieties,
wherein the molecules of FVII of the composition exhibit two O-glycosylation sites at position Ser52 and Ser60
wherein the molecules of FVII of the composition exhibit nine ?-carboxylated N-terminal glutamic acids, and
wherein the molecules of FVII of the composition exhibit 12 specific disulfide bridges.
US Pat. No. 10,364,440

NANOTUBES AS CARRIERS OF NUCLEIC ACIDS INTO CELLS

Brown University, Provid...

1. A method of delivering one or more nucleic acids into a cell comprising contacting the cell with a complex of a rosette nanotube and the one or more nucleic acids in a manner to deliver the complex into the cell, wherein the one or more nucleic acids are released from the complex after entry into the cell.
US Pat. No. 10,362,922

ADSORPTION OF PARTICLES ON A MATERIAL CONTAINING A SILICONE POLYMER

Wacker Chemie AG, Munich...

1. A method for adsorption of particles by triboelectric charging, comprising adsorbing the particles on a material M which comprises an organic polymer material with silicone polymer(s) finely distributed therein, wherein the content of the silicone polymer in the material M is at least 0.0001 wt. % and less than 10 wt. % and wherein said silicon polymer comprises UHMW polysiloxane (ultra-high molecular weight silicone) having a dynamic viscosity from 1 kPa·s to 50 kPa·s at 25° C.
US Pat. No. 10,364,462

COMPOSITIONS AND METHODS FOR POLYNUCLEOTIDE SEQUENCING

Illumina, Inc., San Dieg...

1. A system for characterizing a target polynucleotide, comprising:a polypeptide pore inserted into a membrane having a cis and a trans surface;
a Hel308 helicase contacting the pore on the cis surface of the membrane;
a solution comprising a target polynucleotide and less than 1 mM ATP or analogue thereof contacting the cis surface of the membrane;
an amplifier adapted to provide a potential difference across the membrane;
a processor with instructions to characterize signals from fractional step translocations of the polynucleotide through the polypeptide pore; and
a detector adapted to measure an ionic current flowing through the pore.
US Pat. No. 10,363,210

ORAL CARE COMPOSITIONS

Colgate-Palmolive Company...

1. A toothpaste composition comprising:(i) a whitening complex comprising crosslinked polyvinylpyrrolidone complexed with hydrogen peroxide, wherein the whitening complex contains about 10-30% hydrogen peroxide, by weight, and about 5-15% total nitrogen by weight, and
(ii) 25-40% by weight of humectants selected from propylene glycol, glycerin, and combinations thereof;
(iii) 5-15% by weight of polyethylene glycol of average molecular weight 400 to 800 Da;
and wherein the composition comprises 0.5 to 3% of total hydrogen peroxide by weight of the composition, and wherein the composition comprises less than 2% by weight of water; and
(iv) 25-45% by weight of a calcium abrasive.
US Pat. No. 10,363,213

IMMUNOGENIC COMPOSITION AGAINST CAMPYLOBACTER JEJUNI

The United States of Amer...

1. A method of inducing an immune response in a mammal against a Campylobacter jejuni strain comprising administering to said mammal an immunogenic composition comprising one or more isolated capsule polysaccharides or polysaccharide polymers derived from Campylobacter jejuni strain HS50; wherein said immunogenic composition does not contain Campylobacter jejuni lipooligosaccharide structures associated with Guillain-Barré Syndrome; wherein said immune response is against a Campylobacter jejuni strain of an HS4 complex selected from the group consisting of Campylobacter jejuni strains HS4, HS13, HS4/13/64, and HS50; wherein the structure of HS4 is [?3)-L-?-D-ido-Hep-(1?4)-?-D-GlcNAc-(1?]n, with non-stoichiometric MeOPN at C-4 of LD-ido-Hep; wherein the structure of HS4/13/64 is [?3)-6d-?-D-ido-Hep-(1?4)-?-D-GIcNAc-(1?]n with non-stoichiometric MeOPN at C-2 and/or C-7 of 6d-ido-Hep; and wherein “n” is 1 to 100.
US Pat. No. 10,364,273

CYTOMEGALOVIRUS ANTIGENS

GLAXOSMITHKLINE BIOLOGICA...

1. A recombinant cytomegalovirus (CMV) gB protein, or an immunogenic fragment thereof, wherein(i) said gB protein, or immunogenic fragment thereof, does not comprise a transmembrane (TM) domain;
(ii) said gB protein, or immunogenic fragment thereof, comprises a hydrophobic surface 1 that corresponds to amino acid residues 154-160 and 236-243 of SEQ ID NO: 1 which comprises a mutation that results in a glycosylation site within said hydrophobic surface 1, but wherein the mutation is not a substitution of one amino acid in fusion loop 1 (FL1) which corresponds to amino acid residues 155-157 of SEQ ID NO: 1.
US Pat. No. 10,362,748

WHEAT CULTIVAR 01071526

Monsanto Technology LLC, ...

1. A plant of wheat cultivar 01071526, wherein a sample of seed of said cultivar has been deposited under ATCC Accession No. PTA-125546.
US Pat. No. 10,363,286

PEPTIDE INHIBITION OF CCR3-MEDIATED DISEASES OR CONDITIONS

The Board of Trustees of ...

1. A C—C chemokine receptor (CCR3) peptide analog comprising the amino acid sequence LLNLAISDLLFLVTLPFWIHY (SEQ ID NO:17) or LLFLVTLPFWIHYVRGHNWVFGH (SEQ ID NO:18), wherein said peptide analog is PEGylated and is up to 50 amino acid residues in length.
US Pat. No. 10,363,546

MULTILAYER POLYMERIC MEMBRANE

Liso Plastics LLC, Charl...

1. A multilayer sorbent polymeric membrane comprising at least one layer comprising: a matrix polymer, sorbent materials of about 100 wt. % or less, and a plurality of interconnecting pores having an average pore size of about 0.1 nm or greater,wherein the matrix polymer is a film-forming thermoplastic polymer selected from the group consisting of petroleum-based polymers, bio-based polymers, biodegradable polymers, and combinations thereof;
wherein the sorbent materials present in the membrane retain their initial sorbability and/or their initial porosity of about 100% or less; and
wherein the membrane has a porosity of about 85% or less and a Gurley air permeability of about 1 sec/100 cc or greater.