US Pat. No. 10,245,467

PISTON CONFIGURATIONS FOR PNEUMATIC POGO STICK

Vurtego, LLC, Mission Vi...

1. A pogo stick comprising:a housing having a first end and a second end;
a piston disposed within the housing, such that there is an upper confined space between the piston and the first end of the housing; and
a sliding shaft at least partially disposed within the housing, said sliding shaft connected to the piston and extending from the second end of the housing;
wherein the piston comprises:
an upper rim;
a lower surface;
a cylindrical piston body extending between the upper rim and the lower surface; and
a hollowed out volume of space between the upper rim and the lower surface and within the piston body to form a concave structure, the lower surface enclosing a lower end of the hollowed out volume of space;
wherein the upper rim of the piston defines an opening into the hollowed out volume of space facing the first end of the housing such that the hollowed out volume of space within the piston body is in fluid communication with the upper confined space;
wherein a total internal air volume of the housing includes the hollowed out volume of space at both a maximum extension of the piston and at a maximum compression of the piston to reduce a compression ratio of the total internal volume of the housing.

US Pat. No. 10,245,466

FOOT STRETCHING AND STRENGTHENING APPARATUS

1. An apparatus for stretching and strengthening the forefoot of a user, comprising:a pair of parallel leg members having first and second ends, wherein each lea member is a hollow tube having a cross bore at each first and second end;
a curved barrel bridging the pair of leg members and positioned intermediate the first and second end of each leg member, the barrel providing a support for the arch of a user's forefoot for flexing and strengthening the forefoot over the barrel; and
a removable elastic band positionable over the leg members intermediate the first end and the barrel to hold the toes of the user's forefoot over the barrel during flexing of the foot, further comprising a pair of extenders, each extender adapted to fit within the hollow tube and extend therefrom, and wherein each of the extenders is sized to fit within one of the cross bores.

US Pat. No. 10,245,465

DEVICE FOR PELVIC LIMB BLOOD FLOW

1. A device for pelvic limb blood flow comprising:a vertical supporter extending vertically from a lower plate of a main body in a vertical direction;
a rotary shaft configured in a form of a bar at a predetermined height on the vertical supporter and extending horizontally from the vertical supporter in;
left and right rotary bars each having an upper end and a lower end that are configured to rotate up and downward, respectively, around the rotary shaft;
first and second weights provided at the upper ends of the left and right rotary bars, respectively; and
left and right footplates provided at the lower ends of the left and right rotary bars, respectively,
wherein when a user sequentially presses on the left and right footplates, the first and second weights sequentially rotate upward by a rotation of the left and right rotary bars around the rotary shaft, respectively, and when the user releases pressure off the left and right footplates, the first and second weights rotate downward by gravity to return the left and right footplates back to an initial position.

US Pat. No. 10,245,464

SQUAT RACK FOR GROUP FITNESS CLASSES

1. A stackable squat rack designed for storability and mobility, comprising a pair of vertical rack members angled on an incline from a vertical position and connected via a crossbar; a pair of vertical support members each connected to a respective vertical rack member of the pair of vertical rack members, the pair of vertical support members configured to support the pair of vertical rack members; a pair of base members connected to each other via a floorbar, said pair of base members adapted to engage a floor surface, said pair of base members each connected to a respective vertical rack member of said pair of vertical rack members and to a respective vertical support member of said pair of vertical support members; a pair of horizontal support members each connected to a respective portion of said pair of vertical support members at one end and to a respective base member of said pair of base members at another end; a plurality of bar supports boated on the pair of vertical support members and said pair of horizontal support members; and two wheels connected to an end of said pair of base members, wherein each of the two wheels are connected to a respective base member of the pair of base members, wherein the pair of base members are angled such that the stackable squat rack is narrower at its rear than its front to allow the stackable squat rack to fit into another stackable squat rack of similar configuration for storage.

US Pat. No. 10,245,463

METHOD AND SYSTEM FOR AN EXERCISE DEVICE

Custom Product Innovation...

1. An exercise device comprising:a flat base comprising a first end and an opposing second end, said flat base configured to engage a flat exercise surface;
a pair of opposing sidewalls extending away from said flat base;
an arcuate upper surface extending between a first edge of said first end and a second edge of said opposing second end between said pair of opposing sidewalls, a first angle defined between said flat base and said upper surface proximate said first end, a second angle defined between said flat base and said upper surface proximate said opposing second end; and
a first coccyx cutout in said upper surface proximate said first end and extending to said first edge, and a second coccyx cutout in said upper surface proximate said opposing second end and extending to said second edge, wherein said first coccyx cutout extends completely through said exercise device and said second coccyx cutout extends only partially through said exercise device.

US Pat. No. 10,245,462

CARRIAGE SIT BOX FOR REFORMER EXERCISE APPARATUS

Balanced Body, Inc., Sac...

1. A sit box for use on a carriage of a reformer exercise apparatus, the sit box comprising:a unitary block shaped body having a rectangular flat top surface portion merging via curved wall portions into an upright front wall, an upright back wall, an upright left side wall, and an upright right side wall, wherein the upright front wall, the upright back wall, the upright left side wall and the upright right side wall terminate at a flat bottom parallel to the rectangular flat top surface portion, the rectangular flat top surface portion having a plurality of features providing a gripping surface for contact with a user's body, wherein the flat bottom has a plurality of spaced recesses including at least two spaced vertical recesses therein adjacent to the upright front wall, each of the at least two spaced vertical recesses adapted to receive therein one shoulder stop of a pair of shoulder stops projecting from the carriage of the reformer exercise apparatus, and wherein a vertical height of each of the at least two spaced vertical recesses, as measured along the respective upright left and upright right side walls and from the flat bottom upward toward the rectangular flat top surface portion, is greater than a horizontal width of each of the respective at least two spaced vertical recesses.

US Pat. No. 10,245,461

STRENGTH TRAINING SYSTEM AND METHOD OF USING SAME

1. An exercise system comprising:a first stationary support member having a lower portion and an upper portion, the upper portion of the first stationary support member being at an acute angle relative to the lower portion of the first stationary support member;
a second stationary support member having a lower portion and an upper portion, the upper portion of the second stationary support member being at an acute angle relative to the lower portion of the second stationary support member;
a first rotatable support member configured to rotate about a first axis between a first position wherein the first rotatable support member is generally adjacent to the upper portion of the first stationary support member and a second position wherein the first rotatable support member is generally adjacent to the lower portion of the first stationary support member;
a second rotatable support member configured to rotate about a second axis between a first position wherein the second rotatable support member is generally adjacent to the upper portion of the second stationary support member and a second position wherein the first rotatable support member is generally adjacent to the lower portion of the first stationary support member;
a first carriage member translatable along at least a portion of the first rotatable support member;
a second carriage member translatable along at least a portion of the second rotatable support member; and
a barbell coupled with the first and second carriage members.

US Pat. No. 10,245,460

APPARATUS, KIT, AND METHOD FOR PERFORMING STRAP-BASED EXERCISES

FITNESS ANYWHERE LLC, Sa...

1. A method for configuring and using an inelastic exercise device, wherein the inelastic exercise device comprises an elongated member having a pair of ends separated by a length, a first loop formed by folding a first portion of said elongated member against a second portion of said elongated member, wherein said second portion of said elongated member is proximate said first portion of said elongated member, and a second loop formed by folding a third portion of said elongated member against said second portion of said elongated member, wherein the third portion of said elongated member is proximate said second portion of said elongated member, said second loop is proximate said first loop, and said second portion of said elongated member is secured to said first portion of said elongated member and said third portion of said elongated member, the method comprising:securing the elongated member to a structure by wrapping a first end of the elongated member around the structure and removably attaching the first end of the elongated member to the second loop using a first strap attachment mechanism;
removably attaching a grip to the first loop using a second strap attachment mechanism; and
performing an exercise by applying force to the grip.

US Pat. No. 10,245,459

SPORTS TRAINING SYSTEM AND METHOD

1. A physical training system for use by a person, comprising:a belt adapted for fixing around the waist of the person and including a plurality of belt extension straps each having a belt connecting mechanism at a top end thereof and a connection loop at a bottom end thereof, each belt extension strap adapted for fixing with the belt at any location therearound and including a length adjustment mechanism adapted for allowing the length of the belt extension strap to be selectively adjusted;
the belt including a loop-type fastening material on both an inside surface and an outside surface thereof, and a cooperative hook-type fastening material on an inside surface thereof at opposing first and second ends, the belt including a buckle mechanism adapted to receive the first and second ends of the belt therethrough, and wherein the belt connecting mechanism at the top end of each belt extension strap includes a hook-type fastening material on an inside surface thereof adapted for fixing about the loop-type fastening material on the inside surface and on the outside surface of the belt to fix the belt extension strap at a desired location on the belt;
two shoes adapted for wearing on the person's feet, each shoe including an outer side, an inner side, a rear end, a front end, a top side, and a bottom side, the shoe including at least four attachment loops, including an inner/front attachment loop attached with the shoe proximate the front end of the shoe on the inner side, an inner/rear attachment loop attached with the shoe proximate the rear end of the shoe on the inner side, an outer/front attachment loop attached with the shoe proximate the front end of the shoe on the outer side, and an outer/rear attachment loop attached with the shoe proximate the rear end of the shoe on the outer side;
a plurality of elastomeric bands each having a first end and a second end, the first end being selectively fixable with the connection loop of any of the belt extension straps, the second end being selectively fixable with any of the attachment loops of the shoes;
whereby with the person wearing the belt and shoes, and with the plurality of elastomeric bands stretched between the connection loops of the belt extension straps and the attachment loops of the shoes, the person while walking or running experiences resistance as each leg extends into a fully extended position, and experiences a reduction or cessation of resistance as each leg retracts into a non-extended position.

US Pat. No. 10,245,458

MUSCLE TRAINING METHOD AND MUSCLE TRAINING SYSTEM

KAATSU JAPAN CO., LTD., ...

1. A muscle training method, comprising the following steps that are repeated alternately to perform training of a muscle of a user:a pressuring and exercise step of winding a belt around an arm of the user, the muscle being in the arm of the user, and applying a specific pressure thereto so as to restrict blood circulation to the muscle without stopping the blood circulation, and having the user perform a load-applied exercise to apply a load of specific weight to the muscle of the user; and
an exercise stopping step of having the user stop the load-applied exercise while continuously applying the specific pressure to the user,
wherein the load-applied exercise is a one-arm curl exercise which is performed by the arm of the user;
wherein
the specific weight is set at 20-30% of a maximum weight necessary for the user to exert a maximum muscle force,
wherein the pressuring and exercise step is performed three times or more including a first pressuring and exercise step, a second pressuring and exercise step, and a third pressuring and exercise step, wherein a number of the load-applied exercise performed in the second pressuring and exercise step is set at ½ or less of the number of the load-applied exercise performed in the first pressuring and exercise step, and a number of the load-applied exercise performed in the third pressuring and exercise step is set at ½ or less of a number of the load-applied exercise performed in the second pressuring and exercise step,
wherein a number of the load-applied exercise performed in the first pressuring and exercise step is set at 25 to 30,
wherein, in the exercise stopping step, a stopping duration of the load-applied exercise is set at 10 to 20 seconds,
wherein the muscle training method further comprises a pressure setting step to set the specific pressure,
wherein the pressure setting step comprises an attachment step, in which the belt is wound around the arm of the user for attachment with a specific attachment pressure, a pressurization step, in which pressure higher than the specific attachment pressure is applied to the user, and a depressurization step, in which the pressure applied in the pressurization step is removed to return to the specific attachment pressure, and
wherein the pressurization step and the depressurization step are performed alternately a plurality of times while setting a value of pressure in a given pressurization step larger than a value of pressure in a preceding pressurization step compared to the given pressurization step, and a pressure applied when a color of a palm of the user turns red or reddish brown in the pressurization step is set as the specific pressure.

US Pat. No. 10,245,457

TRAMPOLINE ASSEMBLY HAVING ADJUSTABLE RESILIENT MEMBERS

1. A trampoline assembly comprising:a trampoline bed;
a trampoline frame that supports the trampoline bed; and
a plurality of spaced apart, resilient members that are attached to and extend substantially between the trampoline bed and the trampoline frame to maintain the trampoline bed in tension, wherein at least one of the plurality of spaced apart, resilient members is an adjustable resilient member that can be selectively adjusted while simultaneously connected to both the trampoline frame and the trampoline bed to selectively adjust the tension of the trampoline bed; and wherein the adjustable resilient member includes a resilient assembly, wherein the resilient assembly includes a single spring, a first plug that is fixedly secured to the single spring, and a second plug that is fixedly secured to the single spring, the second plug being spaced apart from the first plug, a first connector that connects the resilient assembly to the trampoline bed, the first connector including a first externally threaded surface that is threaded into the first plug, and a second connector that connects the resilient assembly to the trampoline frame, the second connector including a second externally threaded surface that is threaded into the second plug, wherein threads of the first externally threaded surface are opposite from threads of the second externally threaded surface such that one of the first externally threaded surface and the second externally threaded surface includes right-hand threads and the other of the first externally threaded surface and the second externally threaded surface includes left-hand threads; wherein the resilient assembly is rotatable (i) in a first rotational direction relative to the first connector and the second connector while the adjustable resilient member is simultaneously connected to both the trampoline frame and the trampoline bed to increase the tension of the trampoline bed, and (ii) in a second rotational direction relative to the first connector and the second connector while the adjustable resilient member is simultaneously connected to both the trampoline frame and the trampoline bed to decrease the tension of the trampoline bed; wherein threads of the first externally threaded surface have a differently spaced pitch than threads of the second externally threaded surface.

US Pat. No. 10,245,455

FIREFIGHTER TRAINING UNIT

Deakin University, Geelo...

1. A firefighter training unit for simulating use of a fire extinguishing system including a hose and liquid spray outlet for expelling a fire extinguishing liquid, the firefighter training unit including:a reel;
a user-manipulable nozzle;
a flexible and elongate member having opposite ends attached respectively to the reel and the user-manipulable nozzle and being partially wound around the reel, wherein rotation of the reel in a first rotational direction allows the flexible and elongate member to be unwound from the reel;
a motor configured to drive the reel in a second rotational direction opposite to the first rotational direction which causes the flexible and elongate member to be wound onto the reel;
one or more devices for providing one or more output signals corresponding to one or more simulated operating conditions of the fire extinguishing system; and
a controller configured to drive the motor in response to the one or more output signals so as to apply torque to the reel in the second rotational direction to simulate forces applied to the hose during operation of the fire extinguishing system.

US Pat. No. 10,245,454

FIREFIGHTER PROTECTIVE GARMENT HAVING A THERMAL BARRIER WITH SPACERS TO INCREASE DISSIPATION OF METABOLIC HEAT

INNOTEX INC., Richmond (...

1. A firefighter protective coat comprising:a plurality of superimposed layers, the plurality of superimposed layers comprising:
an outer shell defining an outermost layer of the firefighter protective coat;
a moisture barrier inwardly affixed to the outer shell; and
a thermal barrier inwardly affixed to the moisture barrier, the thermal barrier defining an innermost layer of the plurality of superimposed layers; and
an array of spacer pads inwardly affixed to the thermal barrier, the array of spacer pads being configured to maintain a gap between the thermal barrier and a firefighter's body when the firefighter protective coat is worn by the firefighter.

US Pat. No. 10,245,453

SAFETY AIRBAG SYSTEM

1. An airbag device to cushion the free fall of a subject from an elevated height comprising:an inflatable base bag capable of sustaining an air pressure;
an inflatable structure comprised of a plurality of individual inflatable members, each comprising:
a wall with an annular cross-section; a top first end that is closed; and
a second end opposite the first end,
wherein the second end is coupled to an exterior upper surface of the base bag and is in fluid communication with the base bag,
wherein a space is located between each of the individual inflatable members and the other inflatable members such that the individual inflatable members do not touch and are not in direct fluid communication with the other individual inflatable members;
a net directly attached by net fasteners to a top portion of the inflatable structure, the net comprising:
a first set of frame members;
a second set of frame members oriented transverse to the first set of frame members;
and
wherein the first set of frame members are coupled to the second set of frame members by a plurality of knots and form a lattice having a plurality of open cells adapted to decelerate and support the subject from free fall; and
a top cover attached indirectly to the base bag, the top cover having a top sheet and side sheets that substantially cover and enclose the inflatable structure, while not being directly attached by fasteners to the net or the inflatable structure.

US Pat. No. 10,245,452

APPARATUS FOR SUSPENDING A LOAD ON A ROPE

TAZ, Saint Vincent de Me...

1. An apparatus for suspending a load on a suspension rope, comprising:a body (3) provided with a means (19, 20) for attaching the load and provided with a stationary member (6) and with a pivotal rocker arm member (7) between which the rope (2) passes and which are capable of immobilizing the body along the rope (2) when said body tilts in a direction determined by the load, wherein the rope comprises a taut upper strand (25), an intermediate portion (26), and a loose strand (27), said body also being provided with a stationary abutment (22) and with an unlocking lever (14) mounted pivotably on this body, said unlocking lever being capable of acting on the pivotal rocker arm member (7) in order to cause the pivotal rocker arm member (7) to pivot with respect to the body (3) as far as said abutment (22) and in order to cause said body (3) to tilt in the opposite direction when the rocker arm member (7) bears against said abutment (22), wherein the rocker arm member (7) has a pinching part (10) located facing a pinching part (9) of the stationary member and a bearing part (12) remote from its pinching part in such a manner that the intermediate portion (26) of the rope extends through a gap (11) separating said pinching parts and in front of said bearing part; wherein said means (19, 20) for attaching the load is located on the side of the stationary member relative to the rope and on the side of the bearing part of the rocker arm member relative to said gap; such that, through the effect of the suspended load, said intermediate portion of the rope is diverted relative to the taut upper strand of the rope and acts on said bearing part (12) of the rocker arm member in the direction that tends to bring the pinching parts closer together, in such a manner as to produce a local pinching effect on the suspension rope between these pinching parts (9, 10); wherein the pinching parts are held together irrespective of whether the loose strand of the rope is taut or loose; wherein said abutment (22) for the rocker arm member limits the gap (11) between said pinching parts (9, 10) to a maximum separation, wherein, in a first phase of releasing the rope, said unlocking lever (14) is configured to act on the rocker arm member (7) in the direction of the distancing of said pinching parts (9, 10) when said unlocking lever (14) is pivoted relative to the body in the opposite direction from the pivoting direction of the rocker arm member (7); and wherein, in a second phase of releasing the rope, said unlocking lever (14) is configured to cause the body to tilt in the direction of the reduction of the deviation of the intermediate portion (26) of the suspension rope relative to said taut strand (25) when the rocker arm member bears against said abutment (22) through the effect of said unlocking lever.

US Pat. No. 10,245,450

ULTRASOUND PROBE FOR FAT AND CELLULITE REDUCTION

Guided Therapy Systems, L...

1. An ultrasound treatment probe for treatment of cellulite, the probe comprising:a piezoelectric ultrasound therapy element connected to a motion mechanism,
wherein the piezoelectric ultrasound therapy element is configured for acoustic coupling to a skin surface,
wherein the piezoelectric ultrasound therapy element is configured for delivery of ultrasound energy at a temperature sufficient to coagulate fat cells in fat lobuli that protrude into a dermis layer to create an appearance of cellulite at a depth under the skin surface,
wherein the motion mechanism is configured to operate with an encoder configured to determine movement of the piezoelectric ultrasound therapy element within the probe,
wherein the motion mechanism moves the piezoelectric ultrasound therapy element to form one or more thermal foci at the depth for coagulating fat thereby reducing an appearance of cellulite.

US Pat. No. 10,245,449

SYSTEMS AND METHODS FOR COUPLING AN ULTRASOUND SOURCE TO TISSUE

Guided Therapy Systems, L...

1. A system comprising:an ultrasound source comprising a transducer;
an acoustically transparent standoff acoustically coupled to the transducer;
an acoustic window at a surface of the standoff, the acoustic window having a thickness of an integer multiple of half wavelength of ultrasound energy emitted by the ultrasound source; and
an ultrasound controller coupled to the transducer, the ultrasound controller configured to cause the transducer to emit the ultrasound energy, the ultrasound energy being frequency swept over time, the ultrasound controller monitoring a coupling status of the ultrasound source by measuring at least a portion of the ultrasound energy that is reflected by the acoustic window.

US Pat. No. 10,245,448

PARTICLE BEAM MONITORING SYSTEMS AND METHODS

Varian Medical Systems Pa...

1. A radiation system comprising:a primary particle beam generator that generates a primary particle beam; and
a monitoring component that monitors the primary particle beam, wherein the monitoring component comprises:
a reaction component configured as an external window through which the primary particle beam exits the radiation system, wherein the reaction component is impacted by the primary particle beam and results of an impact include creation of secondary photons;
a detection component that detects a secondary photon characteristic; and
a primary particle beam characteristic determination component that determines a primary particle beam characteristic based upon the secondary photon characteristic.

US Pat. No. 10,245,447

MAGNETIC RESONANCE IMAGING GUIDED BRACHYTHERAPY WITH DISPLAYING THE CATHETER PLACEMENT POSITION

Koninklijke Philips N.V.,...

1. A medical apparatus (200, 300, 400) comprising:A magnetic resonance imaging system (202) for acquiring magnetic resonance data (244, 250) from an imaging zone (208);
a display (270, 501) for displaying images (252, 500);
a processor (228) for controlling the medical apparatus;
a memory (234) for storing machine executable instructions for execution by the processor,wherein execution of the instructions causes the processor to receive a brachytherapy treatment plan (240) for treating a subject (210),wherein execution of the instructions further causes the processor to acquire (100) planning magnetic resonance data (244) using the magnetic resonance imaging system,wherein execution of the instructions further causes the processor to calculate (102) a catheter placement position (246, 900, 902) and a catheter control command (248) for each of the multiple brachytherapy catheters using the brachytherapy treatment plan and the planning magnetic resonance data, wherein the catheter control command is descriptive of locations and dwell times for the locations for one of the multiple brachytherapy catheters,wherein execution of the instructions causes the processor, for each catheter placement position, to repeatedly:acquire (106) guidance magnetic resonance data (250);
reconstruct (108) an image (252, 500) from the guidance magnetic resonance data;
display (110) the image on the display;
display (112) the catheter placement position on the image;
receive (114) a catheter inserted signal from a user interface;
segment (116) the image to determine the catheter placement position after receiving the catheter inserted signal;
recalculate (116) the catheter placement positions for each remaining catheter placement position after receiving the catheter inserted signal; and
recalculate (116) the catheter control command for the multiple catheters after receiving the catheter inserted signal.

US Pat. No. 10,245,446

MARKER-FLANGE FOR MRI-GUIDED BRACHYTHERAPY

UNIVERSITY OF IOWA RESEAR...

1. A marker-flange for use with a brachytherapy applicator, comprising:a flange body having a first face and a second face, with a hollow chamber positioned in the flange body between the first and second faces;
a cavity comprising a first cavity opening on the first face and a second cavity opening on the second face, the cavity extending through the flange body and dimensioned to receive a tandem in a brachytherapy applicator in a press-fit connection;
a port comprising a port opening positioned on one of the first and second faces of the flange body, the port being configured to communicate with the hollow chamber; and
a sealing agent contained within the port opening, the sealing agent providing an air-tight seal between the hollow chamber and an external environment outside the flange body.

US Pat. No. 10,245,445

INFRARED-RAY LAMP TUBE

Yong-Joo Sin, Yongin-si,...

1. An infrared-ray lamp tube comprising:an elongate tube-shaped housing having an inner space defined therein, wherein the elongate tube-shaped housing have both side open ends;
an infrared-ray emitting array disposed in the inner space, wherein an infrared-ray emitting array includes a plurality of halogen lamp units spacedly arranged in an array in the inner space in a length direction of the elongate tube-shaped housing;
a filtering liquid filling the inner space of the elongate tube-shaped housing;
two plugs respectively fitted into the both side open ends of the elongate tube-shaped housing, and including:
a first plug having an inlet through which the filtering liquid flows into the inner space; and
a second plug opposite to the first plug and having an outlet through which the filter liquid in the inner space flows out; and
a bubble-discharge guide in the inner space in a position adjacent to the outlet, and including:
a front surface facing the first plug, and positioned to conceal the outlet when viewed from the first plug;
an outer circumferential surface spaced apart from an inner surface of the elongate tube-shaped housing with a first gap; and
a rear surface opposite to the front surface, facing the outlet, and spaced apart from an inner wall of the second plug with a second gap being in fluid communication with the first gap such that the filtering liquid in the inner space flows toward the outlet over the front surface through the first pap and the second gap in order.

US Pat. No. 10,245,444

PORTABLE NON-INVASIVE DEVICES FOR INTEGRATIVE MEDICINE AND HOLISTIC HEALING

1. A portable, non-invasive therapeutic device adapted for treatment comprising:a) an energy-emitting plate with a central opening defining a front portion of the device and a wall extending outwardly therefrom and enclosing an hollow interior space behind an the inner surface of the energy-emitting plate, wherein the energy-emitting plate is coated with mineral ore adapted to emit a therapeutically effective level of light energy;
b) a rivet comprised of germanium and located at an approximately center point on the energy-emitting plate:
c) a heating element disposed in the hollow interior space behind the inner surface of the energy-emitting plate and attached to an the inner surface of the energy-emitting plate;
and
d) a power circuit in electrical connection with a microprocessor, which is further in electrical connection with a heater line/heat control circuit, a temperature sensor circuit, a digital display circuit and a switch control circuit, wherein the heater line/heat control circuit is, in turn, in electrical connection with the heating element;
wherein the microprocessor is programmed to cause the heat control circuit to pulse heat the heating element, and in turn, the energy-emitting plate, on and off along a person's body; and wherein the microprocessor further sends digital data to and in digital communications with the digital display circuit and the switch control circuit; and
wherein the energy-emitting plate and the rivet are configured to provide light energy to a subject's body when placed over at least one or more sensitive points or portions of the subject's body.

US Pat. No. 10,245,443

RED LIGHT IMPLANTS FOR TREATING OSTEOPOROSIS

DePuy Synthes Products, I...

1. A method of treating a patient, involvinga) injecting a flowable material into a cancellous bone region of a bone, wherein the material is adapted to facilitate tissue regeneration, and
b) irradiating the cancellous bone region with an effective amount of NIR/red light effective to stimulate bone repair.

US Pat. No. 10,245,442

APPARATUS FOR RELAXING RESPIRATORY TRACT AND BRONCHIAL TUBE

COLOR SEVEN CO., LTD., S...

1. A necklace shape apparatus for treating a respiratory ailment, comprising:a color light therapy device (110) that relaxes a treatment area by emitting color light in a wavelength band of visible light through a color light emitting protrusion (113) formed protruding from a rear surface of a body (111) and positioned in a front of the treatment area for a predetermined duration with a predetermined emitting pattern and causing the treatment area to secrete a material that relaxes the treatment area when an operation button (112) installed on a front surface of the body (111) is pushed and an operation of the color light therapy device (110) is started; and
a pair of neck bends (120) that extend from both side surfaces of the color light therapy device (110), elastically gird a perimeter above the treatment area allowing the rear surface of the body (111) to be placed in front of the treatment area, and having two ends at which pressing protrusions (121) press against an area above and behind the treatment area, wherein the pair of neck bends (120) extend from the both side surfaces of the color light therapy device (110), and a battery (111a) and a printed circuit board (PCB) (111b) are installed inside the color light therapy device (110), and
wherein the color light therapy device (110) comprises:
the body (111) in which a controller (111c) that outputs a color light emitting signal for emitting color light for a predetermined duration with a predetermined emitting pattern according to an operation start signal and at least one of any one of a light emitting diode (LED), an organic LED (OLED), a laser diode (LD), and a three color LED that is allowed to generate various color light as a light source (111d) that is turned on according to the color light emitting signal and emits color light of a wavelength band of visible light for relaxing the treatment area are mounted on the PCB (111b);
an operation button (112) that is installed on the front surface of the body (111) and alternately outputs an operation start signal and an operation end signal every time the operation button (112) is pushed;
the color light emitting protrusion (113) protruding from the rear surface of the body (111) and has a leading end in which a light emitting port (113a) is formed for concentrating color light emitted from the light source (111d) and emitting the concentrated color light to the outside;
a light filter (114) that is installed inside the color light emitting protrusion (113), filters and focuses color light emitted from the light source (111d) and emits the color light through the light emitting port (113a); and
a vibration detection signal generator (115) that is installed inside the body (111) and, when the operation end signal is output and a vibration detector (115a) exposed from the rear surface of the body (111) detects vibrations greater than a predetermined reference value, outputs a vibration detection signal to transmit the vibration detection signal to the controller (111c).

US Pat. No. 10,245,441

IMPLANTABLE DEVICE WITH OPTICAL LEAD

MEDTRONIC, INC., Minneap...

1. An implantable active medical device system comprising:an active medical device;
a lead extending between a proximal portion electrically coupled to the active medical device and a distal end portion configured to emit light, the distal end portion comprising:
a solid state light source disposed within a light transmissive ring element, the light transmissive ring element forming an exterior segment of the distal end portion, the light transmissive ring element defining at least a portion of a hermetic cavity;
wherein the light transmissive ring element is hermetically bonded to an electrode ring element and the electrode ring element forming an exterior segment of the distal end portion.

US Pat. No. 10,245,440

TISSUE TREATMENT APPARATUS AND SYSTEMS WITH PAIN MITIGATION AND METHODS FOR MITIGATING PAIN DURING TISSUE TREATMENTS

SOLTA MEDICAL, INC., Hay...

1. A method of operating a tissue treatment apparatus to transcutaneously treat tissue located beneath a skin surface with electromagnetic energy delivered from a treatment electrode, the method comprising:contacting a first portion of a surface of the treatment electrode with the skin surface, wherein the first portion of the surface of the treatment electrode is exposed through an opening located inside an inner edge of a tip frame;
covering a second portion of the surface of the treatment electrode with the tip frame, wherein the second portion of the surface of the treatment electrode is located between an outer peripheral edge of the tip frame and the inner edge of the opening in the tip frame; and
while maintaining contact between the first portion of the surface of the treatment electrode and the skin surface, transcutaneously delivering the electromagnetic energy from the first portion of the surface of the treatment electrode through the skin surface to the tissue,
wherein the tip frame is composed of an electrically-insulating material.

US Pat. No. 10,245,439

AESTHETIC METHOD OF BIOLOGICAL STRUCTURE TREATMENT BY MAGNETIC FIELD

MEDICAL TECHNOLOGIES CZ A...

1. A method for treating pelvic floor issues of a patient using a time-varying magnetic field applied to a pelvic floor of the patient wherein the time-varying magnetic field is applied to a muscle and/or a nerve innervating the muscle within a body region between coccyx and pubic bone of the patient in order to cause a contraction of the muscle in the pelvic floor, the magnetic field generated by a treatment device which includes a switching device, an energy storage device and a magnetic field generating device, comprising:a) charging the energy storage device;
b) switching the switching device on for a first time period having a duration in a range of 3 to 1000 ?s and enabling a current discharge from the energy storage device to the magnetic field generating device in order to generate an impulse of the time-varying magnetic field and applying the impulse of the time-varying magnetic field to the patient;
c) switching the switching device off for a second time period at least four times longer than the first time period and generating no magnetic field by the magnetic field generating device;
d) repeating steps a)-c) for a third time period having a duration in a range of 5 to 500 ms in order to generate a first train of pulses wherein each pulse consists of the impulse of the time-varying magnetic field and the second time period;
e) switching the switching device off after the third time period for a fourth time period having a duration in a range of 10 to 1200 ms and generating no magnetic field;
f) repeating steps a)-e) at least once during a fifth time period having a duration in a range of 3 to 120 seconds;
g) repeating steps a) and b) and switching the switching device off for a sixth time period at least nine times longer than the first time period and different from the second time period;
h) repeating step g) for a seventh time period having a duration in a range of 1.5 to 6 seconds in order to generate a second train of pulses of the time-varying magnetic field wherein the second train of pulses differs from the first train of pulses and wherein the seventh time period consists of first, second, and third subperiods each having a duration in a range of 0.5 to 2 seconds;
wherein an amplitude of a magnetic flux density of each subsequent magnetic pulse of the second train of pulses increases to a predetermined magnetic flux density value during the first subperiod;
wherein the amplitude of the magnetic flux density of each subsequent magnetic pulse of the second train of pulses maintains the predetermined magnetic flux density value during the second subperiod; and
wherein the amplitude of the magnetic flux density of each subsequent pulse of the second train of pulses decreases during the third subperiod from the predetermined magnetic flux density value;
i) switching the switching device off after the seventh time period for an eighth time period having a duration in a range of 1 to 5 seconds and generating no magnetic field by the magnetic field generating device; and
j) repeating steps g)-i) at least once during a ninth time period having a duration of at least 30 seconds.

US Pat. No. 10,245,438

AUTOMATED EXTERNAL DEFIBRILLATOR

NIHON KOHDEN CORPORATION,...

1. An automated external defibrillator comprising:a first pad at least partially colored in a first color;
a second pad at least partially colored in a second color; and
a main unit to which the first pad and the second pad are connected, the main unit comprising a first guidance surface indicating how to attach the first pad and the second pad,
wherein the first guidance surface comprises a first marker comprising an first indicator capable of being turned on and/or blinked in the first color at a position corresponding to an attachment position of the first pad and a second marker comprising a second indicator capable of being turned on and/or blinked in the second color at a position corresponding to an attachment position of the second pad.

US Pat. No. 10,245,437

SYSTEM AND METHOD FOR PROVIDING NONINVASIVE VENTILATION

INOVYTEC MEDICAL SOLUTION...

1. A system configured to assist minimally trained persons to operate it to provide treatment in emergency situations involving respiratory failure and/or cardiac arrhythmias, said system comprising:A) an Airway and Ventilation device (AV) comprising:
i) a face mask;
ii) at least one sensor adapted to monitor vital signs (VS);
iii) a pressurized oxygen source configured to provide a flow of oxygen via said face mask and an airway to a patient and to adjust the oxygen flow on the basis of said monitored vital signs;
B) an Automated External Defibrillator (AED) device comprising one or more electrocardiogram (ECG) detectors that are adapted to be attached to the chest of said patient and are configured to both monitor ECG and to apply electrical shock to said patient via one or more chest pads;
C) a user interface for providing audible or visual instructions to an operator;
D) components that provide communication functionality;
E) a data management unit adapted to operate said system, to provide instructions to the operator, and to record ECG and VS data said data management unit comprising:
i) a processor;
ii) dedicated software; and
iii) memory units;characterized in that the face mask comprises:a) a face attachment unit configured to be attached and secured to the face of a patient by means of connectors that ensure a tight fitting of the face attachment unit to the face contours;
b) a mask body configured to be releasably connected to said face attachment unit by a quick release/attachment mechanism;
wherein said face mask body comprises:
i) a hollow tube that passes from the interior side to the exterior side of said face mask body and is configured to provide a mouth airway securing channel;
ii) a CO2 sensor configured to measure end tidal CO2 (ETCO2) in exhalations of said patient; and
iii) a ventilation tube connected to a portable ventilator configured to deliver air or oxygen to said patient and to remove exhaled air from said patient; and
wherein said quick release/attachment mechanism is configured to allow quick removal of said mask body from said face attachment unit, leaving only the face attachment unit attached by the connectors to the patients' face and leaving the mouth and nose of the patient exposed to the surroundings; and
additionally characterized in that the processor and dedicated software are configured to determine when to apply electric shock according to evaluation of the state of ventilation, wherein the state of ventilation is evaluated according to the ETCO2 measured in each chest compression applied by the operator to the patient.

US Pat. No. 10,245,436

MINIATURE IMPLANTABLE DEVICE AND METHODS

Stimwave Technologies Inc...

1. An implantation system, comprising:a stylet comprising an elongate member and a first mating feature at a distal end of the elongate member; and
an implantable device configured to receive a wireless signal and to generate one or more electrical pulses from the wireless signal for exciting a tissue, the implantable device comprising:
a cylindrical body defining a longitudinal axis of the implantable device,
a plurality of electrodes distributed along the cylindrical body and configured to deliver the one or more electrical pulses,
an anchoring feature adjacent the cylindrical body and disposed proximal to the plurality of electrodes for securing the implantable device to the tissue, and
a second mating feature disposed proximal to the anchoring feature, disposed in-line with the longitudinal axis of the implantable device, and defining a proximal end of the implantable device, the second mating feature configured to mate with the first mating feature such that the stylet and the implantable device can be delivered percutaneously to a body of a subject together as an assembly;
wherein the assembly of the stylet and the implantable device is sized and shaped to be passed through a lumen of an introducer needle that is of gauge 18 or smaller and further through a percutaneous incision site on the body, and
wherein the stylet is sufficiently rigid such that the assembly of the stylet and the implantable device can be passed through the lumen of the introducer needle and further through the percutaneous incision site on the body.

US Pat. No. 10,245,435

WIRELESS NEURAL STIMULATOR IMPLANTATION

Stimwave Technologies Inc...

1. A method for implanting a neurostimulator system, comprising:inserting an introducer sheath and a needle, carried by the introducer sheath, through an incision site on a patient and into an epidural space of the patient;
withdrawing the needle through the introducer sheath and out of the patient;
after withdrawing the needle out of the patient, inserting the neurostimulator system through the introducer sheath and into the epidural space of the patient, the neurostimulator system comprising an enclosure housing electrodes and at least one passive antenna, the at least one passive antenna configured to receive, via electric radiative coupling, electrical energy and waveform parameters from an antenna located exteriorly to the patient, and the electrodes configured to generate electrical waveforms from the electrical energy and the waveform parameters received at the at least one passive antenna;
advancing the neurostimulator system through the epidural space until the electrodes are positioned adjacent a targeted tissue of the patient so that the electrodes can apply the electrical waveforms to render pain relief therapy to the targeted tissue and in a manner such that a proximal portion of the enclosure remains external to the patient;
removing the introducer sheath from the epidural space of the patient;
removing the proximal portion of the enclosure from the neurostimulator system to leave an implanted portion of the enclosure remaining in the epidural space such that the implanted portion of the enclosure has a customized length that is specific to the patient;
after removing the proximal portion of the enclosure, attaching a cap carrying a radiopaque marker to the implanted portion of the enclosure; and
after attaching the cap to implanted portion of the enclosure, further attaching the cap to a connective tissue at the incision site to anchor the implanted portion of the enclosure to the patient.

US Pat. No. 10,245,434

SYSTEMS, METHODS, AND DEVICES FOR EVALUATING LEAD PLACEMENT BASED ON PATIENT PHYSIOLOGICAL RESPONSES

NUVECTRA CORPORATION, Pl...

1. A method of evaluating a placement of a lead configured to deliver an electrical stimulation therapy for a patient, comprising:programming a pulse generator to generate electrical stimulation to target a sacral nerve or a pudendal nerve of the patient, the electrical stimulation being delivered at least in part via a lead, the electrical stimulation being applied by ramping up a stimulation parameter over time;
detecting, via an observation by a healthcare professional or via feedback provided by the patient, a first physiological response, a second physiological response, and a third physiological response from the patient as a result of the electrical stimulation;
measuring a first value of the stimulation parameter associated with the first physiological response, a second value of the stimulation parameter associated with the second physiological response, and a third value of the stimulation parameter associated with the third physiological response; and
evaluating a placement of the lead inside the patient based on at least one of: a chronological sequence in which the first, second, and third physiological responses occurred, a comparison of the first value with a predetermined threshold, or respective deviations of the second value or the third value from the first value.

US Pat. No. 10,245,433

SELECTIVE HIGH FREQUENCY SPINAL CORD MODULATION FOR INHIBITING PAIN WITH REDUCED SIDE EFFECTS, AND ASSOCIATED SYSTEMS AND METHODS

Nevro Corp., Redwood Cit...

1. A spinal cord modulation system, comprising:an implantable signal generator having a machine-readable medium containing instructions that, when executed, generate a therapy signal having a frequency between 1.5 kHz and 10 kHz, an amplitude between 0.5 mA and 4 mA, and pulse widths between 30 microseconds and 35 microseconds; and
an implantable signal delivery device coupleable to the implantable signal generator and designed to be implanted within a patient's epidural space to deliver the therapy signal from the implantable signal generator to the patient's spinal cord.

US Pat. No. 10,245,432

METHOD AND APPARATUS FOR TREATMENT OF FOCAL DYSTONIA

MED-EL Elektromedizinisch...

1. A method of treating focal dystonia comprising:a. providing a system comprising a stimulating electrode operably connected with a processor configured to set one or more stimulation parameters for an electrical impulse deliverable by said electrode;
b. placing said electrode in communication with at least one muscle;
c. using said processor to set said stimulation parameters such that said electrical impulse is adapted to cause a level of stimulation which does not exceed an excitability threshold of one or more alpha motor neurons located within said at least one muscle; and
d. delivering said electrical impulse to said at least one muscle.

US Pat. No. 10,245,431

REAL-TIME SEIZURE PREDICTION INFORMED BY HIDDEN MARKOV MODEL EVENT STATES

The Trustees of the Unive...

1. An implantable medical device for predicting and treating electrical disturbances in tissue, the medical device including:an implantable telemetry unit (ITU) including a processor and an electrode circuit; and
an implantable leads assembly (ILA) including a first electrode and a second electrode implantable in the tissue and electrically coupled to the electrode circuit of the ITU,
wherein the processor of the ITU is configured to perform training by:
receiving electrical signals input to the electrode circuit by the first and second electrodes,
parsing the electrical signals into dynamic event states using Bayesian Non-Parametric Markov Switching, and
modeling each event state as a multi-dimensional probability distribution,
wherein the processor of the ITU is further configured to perform analysis of the electrical signals and therapy to the tissue by:
receiving other electrical signals input to the electrode circuit by the first and second electrodes,
applying the other electrical signals to the multi-dimensional distribution to predict future electrical disturbances in the tissue, and
controlling the electrode circuit to apply an electrical therapy signal to the first and second electrodes to mitigate effects of the future electrical disturbances in the tissue.

US Pat. No. 10,245,430

SIGNAL PROCESSING METHOD FOR COCHLEAR IMPLANT

iMEDI PLUS Inc., Zhubei ...

1. A signal processing method for a cochlear implant, the cochlear implant comprising a microphone and a speech processor, the signal processing method being executed by the speech processor comprising:receiving an electrical speech signal from the microphone;
segmenting the electrical speech signal to a plurality of time-sequenced noisy frames;
reducing noise in each of the plurality of time-sequenced signal frames to obtain a plurality of clean signal frames, the plurality of clean signal frames comprising a (t-1)-th clean frame xt-1 and a t-th clean frame xt;
obtaining a (t-1)-th compression factor ?t-1 according to the (t-1)-th clean frame xt-1;
obtaining a t-th compression factor ?t for the t-th clean frame xt according to the compression factor ?t-1 and the t-th clean frame xt;
obtaining a t-th output frame zt based on the t-th compression factor ?t; and
outputting the t-th output frame zt.

US Pat. No. 10,245,429

METHODS AND APPARATUS FOR RENAL NEUROMODULATION

Medtronic Ardian Luxembou...

1. A method for catheter-based renal denervation of a hypertensive human patient, the method comprising:intravascularly positioning a distal region of a catheter within a renal artery associated with a kidney of the patient; and
at least partially ablating target neural tissue innervating the kidney of the patient via ultrasound energy from the catheter, wherein the ultrasound energy is delivered via an ultrasound transducer carried by a shaft of the catheter,
wherein at least partially ablating the target neural tissue results in a therapeutically beneficial reduction in blood pressure of the patient.

US Pat. No. 10,245,428

IONTOPHORETIC SYSTEM FOR TRANSDERMAL DELIVERY OF ACTIVE AGENTS FOR THERAPEUTIC AND MEDICINAL PURPOSES

INCUBE LABS, LLC, San Jo...

1. A system for transdermal delivery of active agents for therapeutic and medicinal purposes, the system comprising:a power source that generates a charged balanced alternating output current that varies between a first current value and a second current value;
a pair of electrode assemblies comprising a first electrode assembly and a second electrode assembly, each electrode assembly applied to a corresponding skin layer of a user, and wherein each electrode assembly includes an electrode that is coupled to the power source to receive the output current;
an operative interface coupled to the power source, the operative interface being configured to cause the power source to provide output current to the pair of electrode assemblies based on input detected from one or more sensors provided with the user; and
wherein at least one of the electrode assemblies in the pair includes a contact thickness configured to carry an active agent having a charge, the contact thickness being provided on the at least one electrode assembly to enable a corresponding received output current to alternatively repel the active agent into the skin layer from the at least one electrode assembly for a duration in which the output current has a polarity that is the same as a polarity of the active agent, wherein the operative interface, based on the detected input from the one or more sensors, causes the power source to provide output current to the at least one electrode assembly corresponding to (i) a delivery mode in which the output current has the polarity that is the same as the polarity of the active agent, or (ii) a non-delivery mode in which the output current has the polarity that is opposite from the polarity of the active agent.

US Pat. No. 10,245,427

IMPLANTABLE LEAD WITH FLEXIBLE PADDLE ELECTRODE ARRAY

Advanced Neuromodulation ...

1. A neurostimulation lead comprising:a lead body having a proximal end and a distal end
a plurality of conductive terminals being disposed at the proximal end of the lead body;
a flexible paddle being disposed at the distal end of the lead body, the flexible paddle comprising:
a row of laterally aligned flexible electrodes, the row of laterally aligned flexible electrodes at least partially contributing to the formation of a flex line in the flexible paddle; and
a row of laterally aligned nonflexible electrodes longitudinally offset from the row of laterally aligned flexible electrodes such the flex line does not extend across the row of laterally aligned nonflexible electrodes.

US Pat. No. 10,245,426

MEDICAL PATCH

Seoul National University...

1. A medical patch having an electric potential generating structure which is attachable to a wound to thus regenerate injured skin tissues, the medical patch having a piezoelectric potential generating structure comprising a plurality of unit patches stacked one on another, each of the plurality of unit patches comprising a first layer, a second layer and a plurality of piezoelectric nanorods disposed between the first and second layers,wherein when the medial patch is attached to a skin for use, the piezoelectric potential generating structure converts mechanical energy originating from a movement of muscle into a piezoelectric potential,
wherein the plurality of piezoelectric nanorods comprise a plurality of biaxially-grown piezoelectric nanorods, which are aligned horizontally along with in-plane direction of the first layer or the second layer,
wherein the plurality of biaxially-grown piezoelectric nanorods have an average length ranging from 2.5 ?m to 3 ?m and an average diameter ranging from 200 nm to 250 nm, and are symmetrically bent based on middle portion of the nanorods by the muscle movement of the skin to which the patch is attached,
wherein when mechanical load is applied to the biaxially-grown piezoelectric nanorods by the muscle movement of the skin, a first half of each of the biaxially-grown piezoelectric nanorods exhibits positively polarized piezoelectric potentials and a second half opposed to the first half of each of the biaxially-grown piezoelectric nanorods exhibits negatively polarized piezoelectric potentials,
wherein the first and second layers are flexible such that the medical patch is attachable to the skin for use.

US Pat. No. 10,245,425

ELECTRIC DEVICE FOR MEASURING EEG SIGNAL OR ELECTRIC STIMULATION

YBRAIN INC., Seoul (KR)

1. An electric device for measuring an Electroencephalogram (EEG) signal from a subject's head and for providing electric stimulation to the subject's head, the electric device comprising:a plurality of electrode units configured to be attached to each different position of the head of the subject, and configured to
detect the EEG signal from the subject's head, and
supply electric current to the each different position, each of the plurality of electrode units including a plurality of microelectrodes forming an electric array;
an electric stimulation unit configured to supply electric current in order to provide the electric stimulation to the subject's head;
a switching unit connected to the electric stimulation unit and the plurality of electrode units, and configured to switch
the each of the plurality of electrode units to be selectively connected and
each of the plurality of microelectrodes to be selectively connected; and
a controller connected to the switching unit, and configured to
control the switching unit to be selectively connected to each of the plurality of the electrode units to receive the EEG signal from the subject's head through connected electrode unit among the plurality of electrode units, and
control the switching unit to selectively supply, through the switching unit and the connected electrode unit, the electric current from the electric stimulation unit to the subject's head,
wherein the controller is configured to control the switching unit to supply the electric current from the electric stimulation unit to the subject's head through the each of the plurality of the microelectrodes, and
wherein the controller is configured to
receive a first plurality of EEG signals detected from a first plurality of microelectrodes included in first electrode unit among the plurality of electrode units,
select at least one microelectrode, which is configured to simultaneously receive the EEG signal from the subject's head and supply the electric current to the subject's head, from the first plurality of microelectrodes based on the received first plurality of EEG signals,
receive a first EEG signal from the subject's head through the selected at least one microelectrode among the first plurality of microelectrodes, and
control, at the same time as receiving the first EEG signal, the switching unit to supply the electric current to the subject's head through the selected at least one microelectrode.

US Pat. No. 10,245,424

UV STERILIZING CATHETERS AND CATHETER CONNECTORS

1. A catheter connector system releasably connecting a supply port of an intravenous line to a patient connector of an catheter, comprising:a connector body having:
(a) an inner wall defining an interior of the connector body, said inner wall being transmissive to ultraviolet (UV) light; and
(b) an outer wall defining an exterior of the connector body;
one or a plurality of UV light sources disposed between the inner wall and the outer wall or on the outer wall and positioned to emit UV light into the interior of the connector body;
a flow sensor for sensing a flow of fluid in the interior of the catheter;
circuitry for electrically connecting the UV light sources, the flow sensor and a power source, such that electrical power is supplied to the UV light sources when fluid flow is sensed through the interior of the catheter;
wherein the supply port and the inner wall of the connector body are both at least partially transmissive to UV light;
wherein the flow sensor comprises electrodes which extend into the interior of the connector body, wherein electrical power is supplied to the UV light sources when the fluid in the interior of the connector body has a conductivity sufficient to conduct electricity between said electrodes; and
a UV light reflector disposed between the outer wall and inner wall of the connector body or on the outer wall of the connector body and positioned to reflect UV light into the interior of the connector body and said connected supply port.

US Pat. No. 10,245,423

METHOD FOR MANUFACTURING MICROSTRUCTURE USING CENTRIFUGAL FORCE AND MICROSTRUCTURE MANUFACTURED BY SAME

JUVIC INC., Seoul (US)

1. A method for manufacturing a microstructure, the method comprising:applying a viscous material onto a surface of a substrate; and
rotating the substrate about an axis such that the surface faces away from the axis while rotating, which causes the viscous material to extend generally in a direction perpendicular to the surface and away from the axis by centrifugal force applied to the viscous material, thereby providing a microstructure comprising at least one microneedle elongated from and attached to the surface,
wherein the method adjusts at least one dimension of the microstructure which is selected from the group consisting of a length, a diameter, and an aspect ratio by adjusting the centrifugal force.

US Pat. No. 10,245,422

MICROPROJECTION APPLICATORS AND METHODS OF USE

Corium International, Inc...

1. An applicator, comprising:a rigid planar plate member with an upper surface on a first side of the plate member and a lower surface on a second side of the plate member, the plate member having at least one opening therethrough;
a blocking element in contact with the upper surface of the plate member and being capable of moving between a first position and a second position;
a plunger having a proximal end, a distal end on which at least one microprojection is retained, and a shaft extending therebetween, at least a portion of the proximal end rests directly on and is at least partially retained by the blocking element in its first position; wherein, the plunger is slidably accommodated within the opening of the plate member;
an energy-storing element positioned between the lower surface of the plate member and the distal end of the plunger; and
an actuating member having an external surface for application of a force, and having at least one surface in mechanical communication with the blocking element, wherein the actuating member moves the blocking element from its first position to its second position when a force is applied to the external surface of the actuating member, thereby to effect release of the plunger and the energy-storing element.

US Pat. No. 10,245,421

NANOPATTERNED MEDICAL DEVICE WITH ENHANCED CELLULAR INTERACTION

Sorrento Therapeutics, In...

1. A medical device for delivering a drug compound through a stratum corneum and to a subdermal location, the device comprising:a support having an aperture;
an array of microneedles that extend outwardly from the support, wherein at least one microneedle contains a shaft that has an outer wall extending from the support to a tip, wherein the tip and at least a portion of the outer wall are configured to penetrate the stratum corneum, wherein a plurality of nanostructures are spaced about an external surface of the outer wall in a predetermined pattern, and wherein at least a portion of the nanostructures have a cross-sectional dimension of less than about 500 nanometers and greater than about 5 nanometers and an aspect ratio of from about 0.2 to about 5, wherein the microneedle contains a channel in a side of the microneedle, wherein the aperture is in at least partial alignment with the channel of the microneedle, wherein at least a portion of the microneedles has a cross-sectional dimension of from about 1 micrometer to about 1 millimeter; and
a reservoir wherein the drug compound is retained, the reservoir being in fluid communication with the channel of the microneedle for delivery to the subdermal location.

US Pat. No. 10,245,420

MEDICAMENT DISTRIBUTION SYSTEMS AND RELATED METHODS OF USE

PicoLife Technologies, H...

1. A medical device for releasing a medicament, comprising:a multi-layer patch, including:
a base layer configured to secure the patch to a body of a user;
a medicament array located adjacent the base layer, wherein the medicament array includes a plurality of wells each configured to contain and release a quantity of medicament from the medicament array to the body of the user; a bottom surface of each of the plurality of wells being configured to allow the quantity of medicament contained in each well to pass from the well to the body of the user in response to an increase in pressure against the well, and wherein the medicament array is configured to be elevated off of the body of the user when the patch is secured to the body of the user;
a cover layer located on a side of the medicament array opposite the base layer;
a pump operably coupled to the patch and configured to deliver a quantity of fluid to the patch;
a controller operably coupled to the pump; and
one or more sensors configured to measure one or more body parameters, wherein at least one body parameter is at least partially indicative of an effectiveness of the quantity of medicament, wherein the sensors are configured to relay information about the one or more body parameters to the controller, wherein at least one sensor is located on or proximate to the multi-layer patch, wherein at least one sensor comprises one or more electrodes and at least one body parameter comprises nerve conduction velocity, and wherein one or both the controller and pump comprise programming configured to receive input feedback from the one or more sensors, wherein the input feedback is used to adjust one or more dosage and delivery rate.

US Pat. No. 10,245,419

POSITIONABLE VALVULOPLASTY CATHETER

InterValve Medical, Inc.,...

1. A method of operating a balloon catheter comprising:A. advancing a balloon catheter to a valve, said balloon catheter having a balloon disposed at a distal end of an elongated shaft, said balloon having a distal bulb, a proximal bulb, and a waist located between said distal bulb and said proximal bulb, said balloon extending through an annulus of the valve from a first side to an opposite second side of the annulus,
B. said distal bulb being formed from a noncompliant material, said proximal bulb being formed from a material more compliant than said noncompliant material of said distal bulb,
C. inflating said balloon to a first pressure ranging from zero to 0.5 atmospheres to inflate said distal bulb to a fully inflated distal bulb diameter, said proximal bulb having a maximum diameter smaller than said fully inflated distal bulb diameter at the first pressure,
D. positioning said balloon with the waist being positioned in the annulus of the valve and the distal bulb being adjacent to the annulus of the valve at the second side,
E. further inflating said balloon to a second pressure that is larger than said first pressure thereby expanding said proximal bulb to a fully inflated proximal bulb diameter, said proximal bulb expanding against leaflets of the valve,
F. said fully inflated proximal bulb diameter and said fully inflated distal bulb diameter being larger than a waist diameter.

US Pat. No. 10,245,418

APPARATUS FOR A MEDICAL SYSTEM INFLATION SYRINGE

Semler Technologies, Inc....

1. A medical system inflation syringe that enables fluid communication selective interconnectability to other medical systems or devices, by means of removable attachment to a female Luer connector that complies to the ISO 594 standard, said syringe comprising at least a plunger and a barrel, a distal end of said barrel further including a barrel lumen and a nozzle, at least one shroud tab, at least one standoff rib, at least one vent, and a nozzle base, wherein:The nozzle further includes at least an insertion outside diameter, a lumen, and a distal opening at the nozzle's distal-most end, the lumen of the nozzle in open communication with the barrel lumen;
The at least one shroud tab is placed circumferentially around and at a distance from the nozzle and enables a friction fit between the interior wall of the at least one shroud tab and an exterior wall of the female Luer connector;
The at least one standoff rib is placed so that it extends radially from the nozzle and nozzle base to the interior wall of the at least one shroud tab;
The at least one vent is placed at the same distance from the nozzle as the at least one shroud tab and has the same height from the distal end of the barrel as said shroud tab;
The at least one vent enables a backflow of air that escapes from the connected female Luer connector that is not a swabable valve, when air is injected from the syringe into said connected female Luer connector against a resistance on the interior side of said female Luer connector;
The insertion outside diameter is located on the nozzle where the distal-most portion of the standoff rib connects to the nozzle and is less than the minimum inside diameter of any female Luer connector compliant to ISO 594 standard;
The at least one standoff rib has a height, measured from the distal end of the barrel so that when said standoff rib: i) comes into contact with the rim of the female Luer connector that is not part of a swabable valve, and the nozzle is inserted into said female Luer connector, an airtight connection between said connector and the distal opening of the nozzle is precluded, and, ii) comes into contact with the rim of the female Luer connector that is part of a swabable valve, and the nozzle is inserted into said female Luer connector, an airtight connection between said connector and the distal opening of the nozzle is established.

US Pat. No. 10,245,417

PACKAGE FOR EXTENDED SHELF LIFE OF LIQUID CORE CATHETERS

RA MEDICAL SYSTEMS, INC.,...

1. A package assembly to extend a shelf life of a liquid core catheter, comprising:a liquid core catheter comprising a core liquid;
a polymer spiral tube which includes an inner lumen filled with a storage liquid that is soluble in or miscible with the core liquid of the liquid core catheter and which is sealed at both ends to contain the storage liquid in the inner lumen of the polymer spiral tube; and
a sealed pouch which is made of either metallized plastic or polychlorotrifluoroethylene that acts as a hermetic seal for liquids disposed within the sealed pouch and which includes a hermetically sealed inner volume with the polymer spiral tube and liquid core catheter being disposed within the hermetically sealed inner volume.

US Pat. No. 10,245,416

INTRAVENOUS CATHETER DEVICE WITH INTEGRATED EXTENSION TUBE

Becton, Dickinson and Com...

1. An assembled intravenous catheter device, comprising:a catheter adapter having a proximal end, a distal end, and a lumen interposed therebetween, the catheter adapter further comprising a securement platform, the distal end comprising an intravenous catheter and the proximal end comprising an extension tube and an access port extending outwardly from the extension tube, wherein the intravenous catheter, the access port, and the extension tube are in fluid communication with the lumen;
a needle hub having a closed end, an open end, and a compartment interposed therebetween, the closed end being configured to receive a terminal end of the extension tube and the open end configured to receive the proximal end of the catheter adapter, wherein the extension tube is stored within the compartment, the needle hub having an access slot extending through the open end, wherein the access port extends through the access slot and is slidable in a distal direction within the access slot; and
an introducer needle having a base end, a tip end and a body extending therebetween, the base end being securely attached to the closed end of the needle hub, and the body extending through the proximal end, the lumen, the distal end, and the intravenous catheter such that the tip end of the introducer needle is exposed beyond a terminal end of the intravenous catheter.

US Pat. No. 10,245,415

MEDICAL ARTICLE WITH ROTATABLE WINGS

Venetec International, In...

1. A medical device assembly, comprising:a catheter, including a catheter hub;
a housing surrounding the catheter hub, the housing spaced from the catheter hub such that a channel is defined therebetween;
a first wing having a first hook disposed in the channel to permit rotation of the first wing about the catheter hub, the first wing extending from the catheter hub in a first direction; and
a second wing having a second hook disposed in the channel to permit rotation of the second wing about the catheter hub, the second wing extending from the catheter hub in a second direction opposite the first direction.

US Pat. No. 10,245,414

MEDICAL DEVICE WITH SELECTIVE RIGIDITY

Cook Medical Technologies...

1. An expandable and compressible medical device for obtaining selective rigidity with respect to a patient, comprising:an elongate flexible catheter that extends between a distal end portion and a proximal end portion with a first lumen disposed through the catheter, and a second lumen that extends through a catheter wall into the distal end portion, wherein the distal end portion of the catheter wall is an expandable portion;
the catheter wall comprises a first layer that defines an inner surface of the first lumen and a second layer disposed radially outside of the first layer, and wherein the first and second layers are sealed together proximate to a distal tip of the catheter, and an interface is established between the first and second layers, wherein the interface is established within a volume bounded by the first layer, the second layer, and locations where the first and second layers are sealed together, the interface is located within the expandable portion of the catheter wall; and
further comprising a retention member disposed within the interface between the first and second layers within the distal end portion, and wherein the second lumen is fluidly connected with the interface,
wherein the retention member is configured to be aligned in a dense configuration under an influence of a vacuum force applied to the interface via the second lumen, wherein the retention member is biased to expand to a less dense configuration when the interface is at atmospheric pressure,
wherein at least a portion of a surface of one or both of the first and second layers that establish the interface is a sticky portion, and the sticky portion is configured to releasably stick to other portions of the interface under the influence of the vacuum force.

US Pat. No. 10,245,413

DISTAL ACCESS ASPIRATION GUIDE CATHETER

COVIDIEN LP, Mansfield, ...

2. A guide catheter comprising:an elongate tubular member having a proximal end and a distal end and a passageway defining an inner lumen extending between those ends, the elongate tubular member comprising:
a) a relatively stiff proximal segment, the proximal segment comprising an inner proximal tubular liner comprising a proximal liner material in coaxial relationship with an outer proximal tubular cover comprising a proximal cover material, a metallic braid structure positioned upon the inner proximal tubular liner and covered by the outer proximal tubular cover;
b) a relatively flexible distal segment, the distal segment comprising an inner distal tubular liner comprising a distal liner material in coaxial relationship with an outer distal tubular cover comprising a distal cover material, a distal tubular member between the distal liner material and the distal cover material, the distal tubular member comprising and a metal helix defining a helical gap and a polymeric kink resistance member structure positioned within the helical gap, the elongate tubular member, in the region of the distal end, having an inner diameter to wall thickness ratio greater than or equal to 16:1 and a kink radius of about 4.42 millimeters (mm)+/?0.203 mm (about 0.174 inch+/?0.008 inch) or less; and
c) at least one intermediate segment defining a passageway between the relatively stiff proximal segment and the relatively flexible distal segment, the at least one intermediate segment providing a transition from the metallic braid structure to the distal tubular member.

US Pat. No. 10,245,412

CATHETER

ASAHI INTECC CO., LTD., ...

1. A catheter comprising:a catheter body having a distal end and a proximal end and forming a lumen,
a resin front end tip having a lumen in communication with the lumen of the catheter body, the front end tip being attached to the distal end of the catheter body,
a wound body disposed in the catheter body and in the front end tip such that the wound body extends along the lumen of the catheter body, the wound body being a coil and/or a braid, and
a resin reinforcement body disposed at least partly within the front end tip, the resin reinforcement body radially covering the wound body such that the wound body is embedded in the resin reinforcement body, and the resin reinforcement body including a plurality of protrusions extending toward an outer periphery of the front end tip.

US Pat. No. 10,245,411

MEDICAL ELONGATED BODY

TERUMO KABUSHIKI KAISHA, ...

1. A medical elongated body comprising:a tubular main body comprising a lumen, the tubular main body extending in an axial direction, the tubular main body possessing an outer surface, a distal portion and a proximal portion;
a hub connected to the proximal portion of the tubular main body, the hub comprising an interior that communicates with the lumen of the tubular main body, the hub possessing a distal portion; and
a strain relief supported by the distal portion of the hub and surrounding a predetermined range of the proximal portion of the tubular main body;
a hydrophilic lubricating coating layer on the outer surface of the tubular main body, the hydrophilic lubricating coating layer exhibiting lubricating characteristics when wet;
a temperature responsive lubricating coating layer on the outer surface of the tubular main body, the temperature responsive lubricating coating layer exhibiting hydrophilic characteristics and lubricating characteristics at a temperature lower than a critical temperature when wet and exhibiting hydrophobic characteristics and non-lubricating characteristics at a temperature equal to or higher than the critical temperature when wet; and
the temperature responsive lubricating coating layer being proximal to the hydrophilic lubricating coating layer on the outer surface of the tubular main body.

US Pat. No. 10,245,410

RAPID EXCHANGE CATHETER

Cook Medical Technologies...

1. A rapid exchange catheter assembly comprising an outer proximal tube, an outer distal tube, an aperture located at the junction between the distal tube and the proximal tube, and a guide wire tube extending from the aperture and within the distal tube, wherein the distal tube, the proximal tube and the guide wire tube are bonded together at the junction, wherein the aperture is disposed within a distal end portion of the proximal tube, wherein the aperture is disposed proximal of and immediately adjacent to a proximal end of the distal tube, wherein the proximal end of the distal tube has an outer diameter that is greater than an outer diameter of the distal end portion of the proximal tube, wherein a central longitudinal axis of the distal tube is offset from a central longitudinal axis of the proximal tube at the junction so as to form an offset and stepped outer configuration, and wherein an outer surface of the distal tube along a side opposite the aperture is flush with an outer surface of the proximal tube at the junction, andwherein the proximal tube includes a hypotube comprising a tubular portion and a skived portion, the tubular portion having a constant diameter and extending to a proximal end of the assembly, the skived portion extending distally of the tubular portion, the skived portion of the hypotube extending across the junction between the distal tube and the proximal tube, and
wherein an outer surface of the distal end of the proximal tube opposite the aperture is flush with an outer surface of the proximal end of the distal tube at the junction, and wherein an outer surface of the distal end of the proximal tube adjacent to the aperture is disposed inwardly of an outer surface of the proximal end of the distal tube at the juncture.

US Pat. No. 10,245,409

PACKAGING AND ORGANIZING COILS OF MEDICAL TUBING

Fresenius Medical Care Ho...

1. A device for holding medical tubing, comprising:a semi-rigid sheet having a circular shape with an edge region and an interior region disposed radially inward from the edge region on the semi-rigid sheet;
a plurality of adjustable tabs disposed on the semi-rigid sheet; and
a plurality of locking slits that receive the plurality of adjustable tabs in a configuration to secure coils of medical tubing to the semi-rigid sheet, wherein the plurality of adjustable tabs and the plurality of locking slits are disposed on the semi-rigid sheet in:
(i) a front and reverse configuration in which at least one of the plurality of adjustable tabs and at least one of the plurality of locking slits are disposed on a front side of the semi-rigid sheet, and at least another one of the plurality of adjustable tabs and at least another one of the plurality of locking slits are disposed on a reverse side of the semi-rigid sheet, and
(ii) an inverted configuration in which at least one of the plurality of locking slits is disposed in the edge region of the semi-rigid sheet and at least one of the plurality of adjustable tabs is flexible towards the edge region, and at least another one of the plurality of locking slits is disposed in the interior region of the semi-rigid sheet and at least another one of the plurality of adjustable tabs is flexible towards the interior region,
wherein each side of the semi-rigid sheet is configured to hold at least two coils of tubing, including a first coil of tubing at the edge region and a second coil of tubing at the interior region radially within the first coil of tubing, using the plurality of adjustable tabs and locking slits in the front and reverse configuration and the plurality of adjustable tabs and the plurality of locking slits in the inverted configuration.

US Pat. No. 10,245,408

METHOD, APPARATUS AND COMPUTER PROGRAM PRODUCT FOR PROVIDING A DYNAMIC WAKE-UP ALERT

NOKIA TECHNOLOGIES OY, E...

1. A method comprising:determining, with a processor, a sleep recovery need of a user, wherein the sleep recovery need of the user comprises at least one needed sleep quality component and at least one needed sleep duration component, the at least one needed sleep duration component corresponding to a respective one of the at least one needed sleep quality component;
receiving a desired sleep recovery from a user input, the desired sleep recovery being a ratio of the determined sleep recovery need that the user desires to achieve;
adjusting the determined sleep recovery need of the user based on the desired sleep recovery;
in response to a sleep event indication indicative of a sleep event, monitoring with the processor, sleep data relating to the user to calculate a real-time gained recovery indicative of gained sleep qualities and gained sleep durations, each gained sleep durations corresponding to a respective one of the gained sleep qualities, wherein the sleep event indication is generated based on at least a sensor;
comparing the real-time gained recovery to the at least one needed sleep quality component and the at least one needed sleep duration component indicated by the adjusted sleep recovery need of the user to determine that the real-time gained recovery satisfies the adjusted sleep recovery need of the user; and
in response to determining that the real-time gained recovery satisfies the adjusted sleep recovery need of the user, causing a wake-up alert to be provided via a user interface of a device.

US Pat. No. 10,245,407

CONNECTIONS FOR HUMIDIFICATION SYSTEM

14. A cartridge for use with a respiratory humidifier, the cartridge comprising:a housing comprising an upper laterally extending surface, at least one securing member extending upwardly beyond the upper laterally extending surface of the housing,
the housing comprising a rear surface extending downward from the upper laterally extending surface; and
a first rearwardly protruding element extending rearwardly beyond an immediately adjacent portion of the housing and a second rearwardly protruding element extending rearwardly beyond an immediately adjacent portion of the housing, the first rearwardly protruding element and the second rearwardly protruding element being generally vertically aligned, the first rearward protruding element and the second rearwardly protruding element being positioned vertically lower than the upper laterally extending surface,
the first rearwardly protruding element comprising a first deflectable portion and the second rearwardly protruding element comprising a second deflectable portion such that the first deflectable portion and the second deflectable portion are deflectable laterally inward toward each other.

US Pat. No. 10,245,406

VENTILATOR WITH INTEGRATED OXYGEN PRODUCTION

Ventec Life Systems, Inc....

1. A method of providing a breath to a human patient using a ventilator device, a patient circuit having a first end coupled to the ventilator device and a second end spaced apart from the ventilator device, and a patent connection configured to be coupled to the human patient, the breath having an inspiratory phase with a beginning and an end, the method comprising:detecting the beginning of the inspiratory phase of the breath has been initiated by the patient, and in response intiating delivery of a bolus of oxygen to the patient circuit, the patient circuit delivering the bolus of oxygen to the patient connection;
terminating the delivery of the bolus of oxygen before the end of the inspiratory phase of the breath; and
delivering breathing gases comprising air to the patient circuit before the end of the inspiratory phase of the breath, the patient circuit delivering the breathing gases to the patient connection; wherein
delivering the breathing gases to the patient circuit comprises providing the breathing gases to the patient circuit at a first input location of the patient circuit, and
delivering the bolus of oxygen to the patient circuit comprises providing the bolus of oxygen to the patient circuit at a second input location of the patient circuit closer than the first input location to the patient connection.

US Pat. No. 10,245,405

FACE MASK

RIC INVESTMENTS, LLC, Wi...

1. A mask assembly configured to provide gas to a patient, comprising:a mask body having an opening for reception of the gas, the mask body including a seal structure configured to sealingly engage with the face of the patient and surround at least the nose and mouth of the patient, the mask body having a connecting portion; and
an elbow-shaped conduit releasably connected with the connecting portion of the mask body and being configured to deliver the gas to the patient through the opening, the conduit comprising a first connector portion which connects with the connecting portion, and a second connector portion constructed and arranged to connect with a circuit tubing, wherein the first connector portion comprises a plurality of recesses at an interface with the connecting portion to allow exhaled gas to escape therethrough, the conduit being separate and distinct from the mask body and configured to be separate and distinct from the circuit tubing.

US Pat. No. 10,245,404

PATIENT INTERFACE SYSTEMS

ResMed Limited, Bella Vi...

1. A patient interface system for delivering a flow of breathable gas to a patient, comprising:a patient interface support structure configured to be connected to a hose that delivers the flow of breathable gas;
a pair of nasal pillows supported by the patient interface support structure, wherein each nasal pillow is configured to seal against an interior of the patient's nares;
a support member configured to engage a bridge of the patient's nose; and
a connecting member configured to connect the support member and the patient interface support structure,
wherein said pair of nasal pillows is selectively repositionable in a plurality of positions relative to the support member while remaining engaged with the patient's nares.

US Pat. No. 10,245,403

BREATHING MASK ARRANGEMENT AS WELL AS AN APPLICATION DEVICE AND A FOREHEAD SUPPORT DEVICE FOR SAME

1. A respiratory mask assembly for providing respiratory therapy to a patient, the respiratory mask assembly comprising:a frame including a main body and a forehead support extending from the main body, the forehead support including a pair of upper headgear holding members, and the frame further including a conduit carrier portion having an insert opening;
a pair of lower headgear holding members configured to be provided to the main body of the frame;
a mask releasably coupled with the frame, the mask including a body portion and a sealing portion, and
the mask forming a mask internal space pressurizable to a therapeutic pressure above ambient pressure,
wherein the body portion includes a circular inlet opening structured to receive a flow of air at the therapeutic pressure for breathing by the patient,
wherein the body portion includes an inside surface exposed to said therapeutic pressure in use and an outside surface exposed to ambient pressure, and the main body of the frame includes a wall arranged along the outside surface of the body portion so that the wall is outside the mask internal space,
wherein the body portion includes a plurality of outlet openings for discharge of gas from the mask internal space to ambient atmosphere,
wherein the frame includes an opening configured and arranged to expose the plurality of outlet openings when the mask and the frame are coupled to one another,
the sealing portion is constructed and arranged to form a seal with a patient's nose and mouth, the sealing portion including a hole therein adapted to receive the patient's nose and mouth such that the flow of air at the therapeutic pressure is delivered to the patient's nose and mouth,
wherein the sealing portion comprises an elastomer material and the body portion does not comprise an elastomer material;
a positioning and retaining arrangement structured and arranged to releasably couple the mask to the frame,
the positioning and retaining arrangement comprising a mask retainer part provided to the body portion of the mask and a frame retainer part provided to the frame,
wherein the main body, the conduit carrier portion, and the frame retainer part of the frame comprise a one-piece structure,
wherein the frame retainer part is structured and arranged to engage the mask retainer part to releasably retain the mask to the frame;
a respiratory gas conduit member structured to connect to a respiratory gas conduit to deliver the flow of air at the therapeutic pressure to the mask internal space, and the respiratory gas conduit member is mounted within the insert opening of the conduit carrier portion of the frame; and
headgear to maintain the respiratory mask assembly in position on a patient's head, the headgear including upper bands adapted to connect to the upper headgear holding members of the frame and lower bands adapted to connect to the lower headgear holding members, and the upper bands adapted to be routed over respective ones of a patient's ears and the lower bands adapted to be routed under respective ones of the patient's ears.

US Pat. No. 10,245,402

ENDOBRONCHIAL TUBE WITH INTEGRATED IMAGE SENSOR

1. An endobronchial tube comprising:a first lumen having an open distal end;
a first inflatable cuff;
a second lumen having an open distal end;
a second inflatable cuff distal to the open distal end of the first lumen;
a dedicated image sensor lumen located at least partially within a wall of said endobronchial tube, the dedicated image sensor lumen comprising a distal end;
an image sensor and an illumination source, disposed in the dedicated image sensor lumen adjacent the open distal end of said first lumen;
at least one dedicated cleaning lumen disposed within said wall of said endobronchial tube, the at least one dedicated cleaning lumen having a distal end,
wherein said at least one dedicated cleaning lumen curves at the distal end of the dedicated cleaning lumen to form a cleaning nozzle having an opening in an external surface of the dedicated image sensor lumen distal to the image sensor, and
wherein the dedicated image sensor lumen comprises a tubular surface within the wall of the endobronchial tube and a partially annular surface extending from the tubular surface, the partially annular surface forming the external surface of the endobronchial tube on which the opening of the cleaning nozzle is located.

US Pat. No. 10,245,401

SUBGLOTTIC SUCTIONING SYSTEM

Avent, Inc., Alpharetta,...

1. A tracheal tube for a subglottic suctioning system, the tracheal tube comprising:a flexible cannula having a length, a distal end, and a proximal end, the cannula comprising a plurality of separate lumens including a respiratory lumen, a suction lumen and an inflation lumen;
an inflatable cuff surrounding the cannula above the distal end and adapted to seal the trachea of a patient and further having the inflation lumen in fluid communication with the inflatable cuff; and
a port extending through a side wall of the cannula proximal to the inflatable cuff, the port in fluid communication with the suction lumen; and
a valve body located proximal to the cannula, the valve body having
a first valve on the suction lumen on a proximal end of the body having a failsafe open position and a second position that requires positive action by a user to close the suction lumen, and
a check valve that operates independently of the first valve and through which rinsing fluid will flow from a bullet or syringe into the suction lumen distal to the first valve when the bullet or syringe is squeezed by a user,
wherein the first valve returns to the failsafe open position when the positive action by the user stops and the check valve closes and stops the flow of rinsing fluid when the user stops squeezing the bullet or syringe.

US Pat. No. 10,245,400

HANDHELD PRESSURE SUPPORT SYSTEM FOR TREATING HYPERINFLATION

KONINKLIJKE PHILIPS N.V.,...

1. A portable handheld pressure support system configured to deliver a pressurized flow of breathable gas to the airway of a subject, the pressure support system comprising:(a) a pressure generator configured to generate the pressurized flow of breathable gas;
(b) a subject interface configured to communicate the pressurized flow of breathable gas to the airway of the subject;
(c) one or more sensors configured to generate output signals conveying information related to one or more gas parameters of the pressurized flow of breathable gas;
(d) one or more processors configured to execute computer program modules, the computer program modules comprising:
(1) a control module configured to control operation of the pressure generator to generate the pressurized flow of breathable gas based on the output signals from the one or more sensors according to a positive pressure support therapy regime, the positive pressure support therapy regime dictating an inspiratory pressure level and an expiratory pressure level,
(2) a hyperinflation module configured to identify hyperinflation during exhalation based on the output signals, and
(3) an expiratory pressure module configured to control the pressure generator to adjust, responsive to identification of hyperinflation by the hyperinflation module, the expiratory pressure level to relieve hyperinflation during exhalation;
(e) a portable power system configured to power the pressure generator, the one or more sensors, and the one or more processors;
(f) a housing configured to contain the pressure generator, the subject interface, the one or more sensors, the one or more processors, and the power system; and
(g) a handle attached to and/or formed by the housing configured to be grasped by the subject to hold the housing in proximity to the mouth of the subject such that the subject interface contained by the housing is in position with respect to the mouth of the subject to be engaged by the mouth of the subject as the pressurized flow of breathable gas is delivered to the airway of the subject.

US Pat. No. 10,245,399

AUTOMATED INSPIRATORY MUSCLE TRAINING FOR PATIENTS RECEIVING MECHANICAL VENTILATION

UNIVERSITY OF FLORIDA RES...

1. A system for automated inspiratory muscle strength training of a patient during mechanical ventilation comprising:a gas delivery device, wherein said gas delivery device comprises an inhalation assembly that provides breathing gas for inspiratory air flow during patient spontaneous inhalation and includes a valve that controls the breathing gas during a pre-determined number of the spontaneous inhalations;
a control module configured to instruct the gas delivery device to control the breathing gas to maintain a pressure adapted to be below a baseline pressure of a mechanical ventilator during the pre-determined number of spontaneous inhalations; and
a sensing assembly, operably connected to the control module, wherein the sensing assembly, through the operable connection to the control module, is configured to monitor the pressure and facilitate control of the gas delivery device to provide breathing gas for inspiratory air flow.

US Pat. No. 10,245,398

RESPIRATORY HUMIDIFIER AND LIGHTING DEVICE FOR RESPIRATORY HUMIDIFIER

Hamilton Medical AG, (CH...

1. A respiratory humidifier with a lighting device to facilitate observation of the fill level of water in a liquid container from which humidity is added to the breathing gas, the humidifier including a housing with a heating plate and the liquid container with a bottom plate which, when brought into contact with the heating plate, heats the liquid in the liquid container, wherein:the housing includes a projecting portion having a downwardly-facing wall surface with a light-exit portion, the housing containing an electrical light source directed toward the light-exit portion such that light from the electrical light source exits downwardly therefrom;
the liquid container includes an upwardly-facing light-entrance portion directly adjacent to and facing the light-exit portion and positioned above the water therein such that light proceeds from the light source through the light-exit portion and light-entrance portion downwardly into the liquid container to illuminate the surface of the water, and at least certain parts of the container surfaces of the liquid container being transparent.

US Pat. No. 10,245,397

DEVICE AND METHOD FOR PERFORMING RESPIRATORY TRAINING

Rheinisch-Westfaelische-T...

1. An apparatus for respiratory training, the apparatus comprising:a mouthpiece through which a person is able to exhale and inhale respiratory gas;
a variable-volume container forming at least part of a closed space connected to the mouthpiece;
at least one gas-permeable membrane delimiting a part of the closed space on one side and forming on an opposite side a gas-exchange chamber; and
means operated by the respiratory gas flow of the inhaled and exhaled respiratory gas for flowing an O2 or CO2 gas-exchange fluid over the opposite side of the membrane.

US Pat. No. 10,245,396

INHALATION DEVICES AND SYSTEMS AND METHODS INCLUDING THE SAME

Cerecor, Inc., Baltimore...

1. A collapsible inhalation device for use with a metered dose inhaler (MDI) dispenser, the MDI dispenser operable to dispense a dose of a medication therefrom, the inhalation device comprising:an outlet end member including a mouthpiece;
an inlet end member including an inlet port and an MDI dispenser mount structure configured to receive and engage the MDI dispenser; and
a tubular, pliable, collapsible sleeve member having first and second opposed ends attached to the inlet end member and the outlet end member, respectively;
wherein the inhalation device is positionable in each of an open position, wherein the outlet end member and the inlet end member are spaced apart and the sleeve member is extended such that the outlet end member, the inlet end member and the sleeve member define a chamber, and a closed position, wherein the sleeve member is collapsed and the outlet end member and the inlet end member are proximate one another and envelope the sleeve member; and
wherein, when the inhalation device is in the open position with the MDI dispenser mounted in the MDI dispenser mount structure, a dose of the medication can be dispensed from the MDI dispenser into the chamber through the inlet port to mix with air in the chamber and thereby form a mixture of the air and the dose of the medication that can be inhaled by a patient from the chamber through the mouthpiece.

US Pat. No. 10,245,395

METERING SYSTEM AND METHOD FOR AEROSOL DELIVERY

DEKA Products Limited Par...

1. An apparatus for determining the volume of a fluid, the apparatus comprising:a printed circuit board wherein the printed circuit board separates a first volume and a second volume including a gas region and a fluid region, the printed circuit board comprising:
an acoustic source;
a first microphone disposed within the first volume; and
a second microphone disposed within the second volume; and
a processor configured to calculate a change in volume of the gas region wherein the processor determines an amount of fluid output from the fluid region.

US Pat. No. 10,245,394

POWDER DISPERSION APPARATUS, METHOD OF MAKING AND USING THE APPARATUS, AND COMPONENTS THAT CAN BE USED ON THE APPARATUS AND OTHER DEVICES

1. A powder dispensing apparatus, comprising:a support for supporting a powder-containing blister, the blister having at least one wall;
an outlet for communicating a flow of powder to a user of the apparatus;
a feed tube communicating with the outlet, the feed tube structured and arranged to deliver powder from the blister to the outlet;
a deoccluding device arranged within the feed tube, the deoccluding device comprising a bent wire for puncturing the wall of the blister so as to allow an air flow from the blister and into the feed tube, and for deoccluding;
a blister impacting device comprising at least one arm that impacts the blister; and a cutting mechanism configured to create at least one air inlet opening in the wall of the blister, whereby air may be drawn into the blister to aerosolize the powder therein.

US Pat. No. 10,245,393

METHODS, SYSTEMS, AND DEVICES RELATED TO A SUPPLEMENTAL INHALER

Elwha LLC, Bellevue, WA ...

1. A system comprising:circuitry configured to assess one or more parameters associated with flow through at least one flow channel disposed within an inhaler used by a subject to obtain at least one assessed flow value;
circuitry configured to calculate an amount of propellant that will increase flow through the at least one flow channel to meet or exceed a threshold flow value if the at least one assessed flow value is below the threshold flow value including at least circuitry configured to compare the at least one assessed flow value to a particular threshold flow value related to the subject; and
circuitry configured to dispense at least one agent with the amount of propellant that will cause the flow through the at least one flow channel to meet or exceed the particular threshold flow value.

US Pat. No. 10,245,392

OXYGEN CONCENTRATING DEVICE, WOUND CARE APPARATUS, AND TREATMENT METHODS

NEOGENIX, LLC, Fort Laud...

1. A wound care device comprising:an oxygen port for supplying oxygen gas for wound care;
an oxygen concentrating device fluidly connected to the oxygen port, the oxygen concentrating device including:
a first membrane electrode assembly (MEA) for the production of oxygen gas from air, which comprises:
a first electrode fluidly connected to a source of ambient air;
a cover disposed between the first electrode and the source of ambient air, the cover including at least one passage which fluidly connects the first electrode to the source of ambient air such that the cover restricts moisture loss from the first electrode,
a second electrode spaced from the first electrode, the second electrode being fluidly connected to a first basin such that the first basin is fluidly connected to the oxygen port, and
a first ion conducting membrane positioned between the first and second electrodes, which comprises:
a first conductive wire connected to the first electrode, and
a second conductive wire connected to the second electrode, such that the application of a substantially constant flow of electrical current through the first conductive wire and the second conductive wire electrochemically produces oxygen on the second electrode from ambient air adjacent the first electrode, and such that when the source of ambient air has an ambient relative humidity which is equal to or less than 30%, the voltage across the first electrode and the second electrode increases less than 25% after 15 days of electrochemically producing oxygen on the second electrode as the result of the application of the substantially constant flow of electrical current;
wherein the at least one passage has a radius that is equal to or greater than 0.159 mm.

US Pat. No. 10,245,391

FLUID RESERVOIR FOR AN AEROSOL GENERATION DEVICE, COMBINATION OF FLUID RESERVOIR AND PRIMARY FLUID PACKAGE, AND AEROSOL GENERATION DEVICE FOR USE WITH THE FLUID RESERVOIR

PARI Pharma GmbH, Starnb...

1. A fluid reservoir which is attachable to an aerosol generation device for guiding a fluid to the aerosol generation device, the fluid reservoir comprising:a fluid container; and
an interface portion affixed to the fluid container and configured to attach the fluid container to the aerosol generation device, wherein
the interface portion includes a locking element configured to lock the fluid container to the aerosol generation device after attachment of the fluid container to the aerosol generation device, and
the interface portion includes a weakened portion that is breakable to enable detachment of the fluid container from the aerosol generation device.

US Pat. No. 10,245,390

ADHESIVE AND PERIPHERAL SYSTEMS AND METHODS FOR MEDICAL DEVICES

DEKA Products Limited Par...

1. A needle injector device for connection in fluid-flow communication with the inlet or outlet port of a reservoir, the needle injector comprising:a housing;
a hollow needle supported in the housing for movement relative to the housing between a start position, an extended position and a retracted position, the needle having a piercing end having an opening and an opposite, second end having an opening;
a fluid conduit connected to the opening on the second end of the hollow needle and moveable with the hollow needle;
a first bias member supported by the housing and arranged to impart a first bias force in a first direction on the attached needle from the start position to the extended position of the needle;
a second bias member arranged to impart a second bias force in a second direction, opposite to the first direction, for moving the attached needle from the extended position to the retracted position;
wherein at least a portion of the first bias member is located outside the housing, and wherein at least a portion of the second bias member is located outside the housing.

US Pat. No. 10,245,389

ADHESIVE AND PERIPHERAL SYSTEMS AND METHODS FOR MEDICAL DEVICES

DEKA Products Limited Par...

1. A delivery device for delivering an infusion medium to a user, the device comprising:a disposable housing assembly adapted to be secured to a user's skin;
a reservoir having an interior for containing a fluidic medium, the reservoir having an outlet port and being operatively coupled to a pumping assembly to selectively drive fluid out the outlet port from the reservoir interior;
a base portion comprising the reservoir, the base portion having a reservoir cavity, and a fluid path, the reservoir cavity comprising the outlet port and a septum, the fluid path comprising a fluid channel from the outlet port to a cannula port;
at least one flexible membrane portion attached onto the base portion and forming a top of the reservoir cavity and a top of the fluid channel; and
a tubing connected to the base portion at the cannula port, the tubing in fluid communication with the reservoir cavity; and
a needle insertion device for inserting a cannula into the user's skin, the needle insertion device comprising an introduction needle for movement between a retracted position and an extended position;
wherein the disposable housing assembly has a passage through which the introduction needle extends, and
wherein the cannula has a central passage through which the introduction needle extends.

US Pat. No. 10,245,388

INJECTION DEVICE FOR MINIMALLY INVASIVE PROCEDURES AND USES THEREOF

Global Bio Therapeutics, ...

1. An injection device, comprising:a) a syringe barrel, wherein the syringe barrel provides a fluid reservoir;
b) a plunger configured to be controlled by the operator of the device and to move within the syringe barrel for loading and releasing fluid from the fluid reservoir in the syringe barrel;
c) an injection needle that is fixed and operably coupled to the syringe barrel providing a fluid pathway for fluid contained in the syringe barrel to be injected into a target tissue when the plunger is depressed, wherein extraction or retraction of the needle is independent of movement of the plunger;
d) an elongate sheath, comprising an internal lumen that contains the injection needle and having a distal tip that contains an opening for the injection needle, wherein:
the sheath is movable around the injection needle; and
control of the sheath is independent from movement of the plunger; and
e) a controller for positioning the sheath, comprising:
a housing, comprising at least a first and second stop to control exposure of the injection needle and that are provided within the housing at a predetermined distance from each other, wherein the stops can be locked;
a central lumen in the housing comprising a connection member, wherein the connection member is configured to be movable in the central lumen in the housing and is coupled to the sheath, wherein the proximal end of the sheath is coupled to the distal end of the connection member so that movement of the connection member controls movement of the sheath; and
a positioner mounted within the housing configured to move forward towards the distal end of the controller and rearward towards the proximal end of the controller, between the stops in the housing, wherein the positioner comprises a lock and release element that is configured in the positioner to engage the positioner with the stops, and is operatively connected to the connection member to guide movement of the connection member in the same direction, whereby movement of the positioner forward towards the distal end engages the first stop and moves the sheath to enclose the injection needle inside the lumen of the sheath, and movement of the positioner rearward towards the proximal end engages the second stop and moves the sheath to expose no more than a predetermined length of the distal tip of the injection needle through the opening for the injection needle for injection into the tissue.

US Pat. No. 10,245,387

MEDICAMENT DELIVERY DEVICE

SHL MEDICAL AG, Zug (CH)...

1. A multi-dose medicament delivery device comprising:a device front end;
a device back end;
a central longitudinal axis;
a housing having a housing front end and a housing back end;
a medicament container assembly, the medicament container assembly being configured for accommodating a medicament container with a stopper;
a dose drum that is supported in the housing via a first threaded connection;
wherein the dose drum is axially movable with respect to the housing in a backward direction from an initial position to at least one dosing position when rotated in a first direction in order to set a dose to be delivered; and
wherein the dose drum is axially movable with respect to the housing in a forward direction from the dosing position to the initial position when rotated in a second, opposite direction in order to deliver the dose set;
a plunger rod that is operationally associated with the stopper and supported in the housing via a second threaded connection, wherein the threaded connection is configured to axially guide the plunger rod toward the device front end when the plunger rod is rotated in the second direction, where the plunger rod has an inner surface with an inwardly radial protruding tooth corresponding to a predetermined dosing position; and
an activation assembly comprising:
a plunger rod rotator that is coupled to the dose drum and has at least one first deflecting member comprising an outwardly radial protruding tooth;
an activator rod that is axially movable with respect to the plunger rod rotator from an uncoupling position to a coupling position, wherein, when the activator rod is in the coupling position and the dose drum is rotated in the second direction from the dosing position the plunger rod does not rotate until the outwardly radial protruding tooth of the at least one first deflecting member engages the inwardly radial protrusion; and
at least one second deflecting member that is configured to lock the activator rod with respect to the plunger rod rotator in the coupling position until the dose drum reaches the initial position again.

US Pat. No. 10,245,386

FORCE AMPLIFIER

Niswey, L.L.C., Atlantic...

1. A linear force amplifier, comprising:a housing having a length;
a force multiplier having an input screw substantially non-rotating relative to said housing and having an axis, to which an input force to be amplified is applied relative to said housing, an output screw substantially non-rotating relative to said input screw, providing a resulting output force relative to said housing, and a rotating nut rotatable about said input screw axis and disposed to receive and engage each of said input screw and said output screw and disposed to engage said housing and provide a force to said housing opposite to said resulting output force, wherein said output screw is movable in a first direction when said input force is applied and is retractable opposite said first direction upon relief of said input force;
an advancement ratchet disposed to engage said output screw and receive said output force relative to said housing having an output member providing an increasing ratchet output member displacement in said first direction in response to a plurality of cycles of force multiplier output screw motion in said first direction advancement and retraction therefrom.

US Pat. No. 10,245,385

REMOVABLE DISPOSABLE CONTAINER FOR MEDICAMENT DELIVERY AND TRAINING

JBCB HOLDINGS, LLC, Orla...

1. A medicament device configured to provide stepwise instructions for using the device to a user in a particular sequence, the device comprising:a reusable housing comprising a receptacle for receiving a container, said reusable housing comprising a control interface, the control interface comprising at least one responsive member reactive to a user input;
a container removably receivable within the receptacle, the container comprising a first housing and a second housing, a first spring disposed between the first and second housings, and an injection member or an Injection simulation member associated with a lower portion of the first housing, a first contaminant barrier disposed at a distal portion of the second housing and a second contaminant barrier disposed between the first and second housings;
an actuation member configured to interact with the container;
a signal output component associated with the reusable housing;
circuitry associated with the reusable housing configured to control a provision of the stepwise instructions to the user in the particular sequence;
at least one sensor to detect a condition of the device, wherein the at least one sensor comprises a sensor for detecting a contact between the device and the user; and
a program code module to record an error condition of the device, wherein the error condition comprises an error in using the device based at least in part on an input form the at least one sensor, said error condition comprising at least one of: 1) a use of the device in an incorrect sequence; 2) a failure to complete a step in the use of the device; or 3) a failure to perform one or more steps in the sequence within a predetermined time period, such that a feedback is provided to the user via the signal output component about the use of the device during the use, and sterility of the injection member or injection simulation member is maintained from prior to insertion of the container into the reusable housing through delivery member from the container by at least the first and second contaminant barriers, and sterility of a medicament contained within the first housing is maintained by at least the second contaminant barrier until the medicament is delivered through the injection member.

US Pat. No. 10,245,384

SENSOR FOR USE WITH A DRUG DELIVERY DEVICE

Sanofi-Aventis Deutschlan...

1. An optical decoding system comprising:a single optical sensor integral with or attachable to a housing of a drug delivery device and configured to be directed at first and second rotatable components of a dose setting and dispensing mechanism of the drug delivery device; and
a processor configured to:
cause the single optical sensor to capture one or more images of the first and second rotatable components at least at a beginning and an end of a medicament dose dispensing process;
determine a rotational position of both the first and second rotatable components in each of the captured images; and
determine from the rotational positions of the first and second rotatable components an amount of medicament delivered by a dose setting and a dispensing mechanism of the drug delivery device.

US Pat. No. 10,245,383

INJECTION DEVICE

1. An injection syringe apparatus by which a dose can be set by rotating a dose setting member and by which an injection button elevates from an end of the syringe apparatus a distance proportional to the set dose, the injection syringe apparatus comprising:a. a non-rotatable, longitudinally displaceable, guided threaded piston rod having a distal end for pressing medicine out of a cartridge;
b. a tubular element that is rotatable and axially displaceable, wherein the injection button is fixed to the tubular element at a proximal end of the tubular element so that the injection button rotates and translates with the tubular element;
c. a housing element;
d. a nut element threadedly engaging the thread on the piston rod thereby forming a first threaded arrangement, wherein the nut element screws up the piston rod away from a defined position in the housing element and can be pressed back to the defined position carrying the piston rod with it when a set dose is injected, wherein the axial distance the nut element is moved is less than the axial distance the injection button is moved; wherein the nut element comprises a connecting element comprising a tubular connection element for rotating the nut element when the dose setting member is rotated;
e. a dose setting drum that rotates during the setting of a dose, the dose setting drum being threadedly engaged with the housing element via a second threaded arrangement so that when the threaded dose setting drum is rotated it is axially displaced relative to the housing element, wherein the second threaded arrangement is different than the first threaded arrangement so that the injection button has a larger stroke than the piston rod;
f. a helical scale disposed on an exterior surface of the dose setting drum; and
g. a coupling that couples and decouples rotational motion of the dose setting drum with the tubular element and the injection button, the coupling comprised of a pair of releaseably engageable elements, wherein when a dose is set by rotating the dose setting drum, the tubular element and dose setting drum rotate together but when a user injects a dose by pressing on the injection button, the dose setting drum is rotationally decoupled from the tubular element so that the dose setting drum rotates back to a zero position while the tubular element, the nut element, the piston rod, and the injection button move axial without rotating.

US Pat. No. 10,245,382

PNEUMATIC NEEDLE-FREE INJECTION DEVICE

1. A pneumatic needle-free injection device comprising:a tube body having a hollow configuration and including a first connecting end, a second connecting end, and at least one through hole;
a linking element including a first linking end engaged with the second connecting end of the tube body, a first concave portion formed at said first linking end, a second linking end, and a second concave portion formed at said second linking end; a through hole formed between said first and second concave portions;
a rear section including a third connecting end engaged with the second linking end of the linking element, a first axial hole formed in the rear section and communicating with the second concave portion of the linking element, and a screw hole formed at an end of the rear section in opposing relationship to the third connecting end;
a solenoid disposed inside the tube body, the solenoid including a coil, a hollow tube formed inside the coil, and an electric wire connected to the coil and passing through the at least one through hole of the tube body;
a printed circuit board disposed outside the tube body and electrically connected to the electric wire to control operation of the coil;
an engaging element having two ends with one end thereof fixedly engaging a rear section of the hollow tube, and another end of the engaging element fixedly engaging the first concave portion, and the engaging element having a second axial hole communicating with the through hole of the linking element;
a movable element disposed inside the hollow tube at a front section thereof and having a third axial hole therein, said movable element being displaceable by a magnetic force from the solenoid;
a storage device including a cylinder and a cap; said cylinder defining a shrunk opening at a front end thereof, said cap covering a rear opening of the cylinder and engaged within the first connecting end of the tube body; said cap having a through hole engaged with the front section of the hollow tube;
a moving rod having a tail end connected to the movable element and a front end formed with an abutting section which has a greater diameter than the shrunk opening, and the moving rod being displaced for controlling opening and closing of the shrunk opening, said abutting section having a stick extending from a front thereof and the stick stretching into the shrunk opening, said tail end having a fourth axial hole communicating with the third axial hole, and a front of the tail end having at least one radial hole;
a first spring disposed in the second axial hole of the engaging element and the third axial hole of the movable element to provide elasticity for the movable element and the moving rod and thereby displace the abutting section forward to close the shrunk opening and define a pressure room inside the storage device, wherein pressurized air flows through the first axial hole, the second axial hole, the third axial hole, and the fourth axial hole in sequence and then to the pressure room via the at least one radial hole;
a housing having said tube body, said linking element, said rear section, said solenoid, said printed circuit board, said engaging element, said movable element, said storage device, said moving rod, and said first spring disposed therein, a front end of the shrunk opening being exposed through said housing, and said housing having at least one button on a surface thereof electrically connected to the printed circuit board; and
a pressure delivery tube engaged to the front end of the shrunk opening with a delivery hole therein connecting to the shrunk opening;
whereby the solenoid controls displacement of the movable element and the abutting section to ensure circulation of the pressurized air in the pressure room for delivery at high speed and under high pressure into the delivery hole via the shrunk opening.

US Pat. No. 10,245,381

TWO-STEP AUTO-INJECTION DEVICE

Chalbourne Brasington, G...

1. An auto-injection device defining a longitudinal direction, the auto-injection device comprising:an ampoule, the ampoule comprising a fluid medicament contained between a first stopper located towards a proximal end of the ampoule and a second stopper located towards a distal end of the ampoule, wherein the first stopper includes a first recess located at a proximal edge of the first stopper and a second recess located at a distal edge of the first stopper, wherein the second recess is disposed between the first recess and the second stopper;
a first sleeve movable along the longitudinal direction relative to the ampoule;
a second sleeve at least partially surrounding the ampoule and movable along the longitudinal direction relative to the ampoule, wherein the second sleeve is movable from a proximal end of the auto-injection device towards a distal end of the auto-injection device; and
a needle located at the proximal end of the auto-injection device;
wherein the first sleeve is movable along the longitudinal direction relative to the second sleeve and the ampoule between a first position and a second position, wherein in the first position the needle is unexposed along the longitudinal direction and in the second position the needle is exposed along the longitudinal direction, further wherein a proximal end of the first sleeve is in direct contact with a proximal end of the second sleeve in the second position, and
wherein the second sleeve is movable along the longitudinal direction relative to the ampoule between a first position and a second position, wherein in the first position the needle is fluidly isolated from the fluid medicament and in the second position the needle is in fluid communication with the fluid medicament.

US Pat. No. 10,245,380

CONTAINER CLOSURE, CONTAINER ASSEMBLY AND METHOD FOR UTILIZING THE SAME

William Beaumont Hospital...

1. A portion of a container assembly comprising:a container closure including an end wall connected to a side wall, wherein the end wall includes a central portion and an outer perimeter portion, wherein the side wall includes a proximal end and a distal end, wherein the proximal end of the side wall is connected to and extends away from the outer perimeter portion of the end wall, wherein the end wall includes an inner surface and an outer surface, wherein the side wall includes an inner surface and an outer surface; and
a needle sheath member that extends axially away from and is integral with the inner surface of the end wall of the container closure, wherein the needle sheath member forms a needle-receiving passage that is sized for receiving a needle extending from a needle hub that is removably-attached to a syringe, wherein the needle-receiving passage is in fluid communication with a needle hub-engaging portion that is defined by the outer surface of the end wall of the container closure, and wherein the needle hub-engaging portion is sized for receiving the needle hub that is removably-attached to a syringe;
wherein the outer surface of the end wall of the container closure defines a syringe-engaging portion, and
wherein the container closure includes a fluid-drawing member that extends axially away from and is integral with the inner surface of the end wall of the container closure, wherein the fluid-drawing member includes a proximal end and a distal end, wherein a fluid-flow passage extends through the fluid-drawing member between the proximal end of the fluid-drawing member and the distal end of the fluid-drawing member, and wherein the proximal end of the fluid-drawing member is connected to and extends away from the inner surface of the end wall of the container closure.

US Pat. No. 10,245,379

CANNULATED DOSE DELIVERY DEVICE, SYSTEM AND METHOD OF USE

Med Dose Solutions, LLC, ...

1. An apparatus comprising:a plunger housed in a barrel, wherein the plunger comprises;
a plunger proximal end connector configured to receive a washing agent;
a plunger end cap configured to facilitate the washing of a delivery chamber of the barrel;
an elongated cylinder having an internal chamber defining a fluid pathway between the plunger proximal end connector and the plunger end cap; wherein the plunger end cap comprises a plurality of slits in the distal end of the plunger end cap, wherein the slits are spaced apart.

US Pat. No. 10,245,378

RESERVOIR VOLUME SENSING

MEDTRONIC, INC., Minneap...

1. An implantable medical infusion device comprising:a housing;
an expandable reservoir located in the housing to contain therapeutic fluid, wherein the expandable reservoir defines a volume and is configurable between an empty state and a full state, wherein the expandable reservoir comprises a movable wall that moves in response to the expansion and contraction of the expandable reservoir between the empty state and the full state; and
a light-based volume sensor located in the housing to sense a light signal representative of a distance between the volume sensor and the movable wall of the expandable reservoir to determine the volume of the expandable reservoir, wherein the light-based volume sensor transmits and receives light to and from the movable wall through the volume of the expandable reservoir.

US Pat. No. 10,245,377

DRUG DELIVERY SYSTEMS WITH SEALED AND STERILE FLUID PATHS AND METHODS OF PROVIDING THE SAME

INSULET CORPORATION, Act...

1. A system, comprising:a container having a main body and a neck, the container configured to hold a liquid drug;
a cap coupled to the neck, the cap configured to seal an open end of the container;
a fluid path having a first end disposed within the cap and a second end disposed within a cover;
an energy source configured to emit energy; and
a shield positioned adjacent to the container, the shield configured to expose the fluid path to the emitted energy while blocking exposure of the liquid drug to a substantial portion of the emitted energy.

US Pat. No. 10,245,376

ASSEMBLY INCLUDING A NEEDLE FOR ADMINISTERING A FLUID

Sanofi, Paris (FR)

1. An assembly comprising:a needle for administering a fluid, the needle comprising:
a hollow needle body configured to guide the fluid, the needle body being formed such that an inlet section of the needle body defines a first flow direction for the fluid, and an outlet section of the needle body defines a second flow direction for the fluid, wherein the first flow direction is inclined with respect to the second flow direction, and wherein the needle body comprises a bend which connects the inlet section and the outlet section;
a needle unit comprising the needle, the needle being fixed to a needle hub, wherein the needle unit further comprises a needle housing which covers a part of the bend of the needle body,
a reservoir retaining fluid, wherein the needle is fluidly connected to the reservoir, and
an assembly housing, wherein the needle unit is rotatably mounted to the assembly housing such that the needle hub is axially secured but rotatable with respect to the assembly housing, the needle unit being rotatable relative to the assembly housing such that a longitudinal axis of the outlet section of the needle body points toward a dose member.

US Pat. No. 10,245,375

SELF-ORIENTING SYRINGE AND SYRINGE INTERFACE

BAYER HEALTHCARE LLC, Wh...

1. A medical injector comprising at least one syringe port for engaging a syringe, the at least one syringe port comprising a locking mechanism comprising: a housing; a first retaining ring at a distal end of the housing, the first retaining ring having a central opening and a sidewall, wherein the sidewall has one or more first recesses extending radially outward into the sidewall and lateral surfaces of each first recess defining a travel path for guiding movement of one or more retaining lugs of the syringe; anda second retaining ring that is rotatable relative to the first retaining ring and the housing,
wherein the second retaining ring comprising one or more locking elements extending radially inward from an inner sidewall of the second retaining ring and are separated by one or more second recesses for receiving the one or more retaining lugs when an insertion section of the syringe is inserted through the central opening of the first retaining ring, wherein the one or more locking elements comprise a first inclined surface for engaging a corresponding inclined surface of the one or more retaining lugs for axially ejecting the syringe upon disengagement of the syringe from the at least one syringe port.

US Pat. No. 10,245,374

SYRINGE PUMP

DEKA Products Limited Par...

1. A syringe pump for administering an agent to a patient, the syringe pump comprising:a plunger head assembly configured to actuate a syringe;
at least one latch configured to releasably secure the syringe to the plunger head assembly;
a shaft disposed within the syringe pump;
a sliding block assembly configured for engaging with a lead screw to move along the lead screw in accordance with rotation of the lead screw, wherein the sliding block assembly comprises:
a half-nut housing having a lead screw void configured to receive the lead screw therewithin;
a half nut disposed within the half-nut housing and having half nut threads at an end adjacent to the lead screw void, the half nut is slideable between an engagement position whereby the half nut threads engage with threads of the lead screw thereby creating slack and a disengagement position whereby the half nut threads are disengaged from the threads of the lead screw, wherein the half nut includes a cam follower surface and a half nut slot; and
a barrel cam disposed within the half-nut housing and configured to engage with the cam follower surface, the barrel cam includes a pin configured to fit within the half nut slot, wherein the barrel cam is configured to rotate between a first position and a second position to actuate the half nut between the engagement position and the disengagement position, respectively.

US Pat. No. 10,245,373

PUMP CASSETTES WITH POSITIONING FEATURE AND INFUSION PUMP SYSTEMS

CareFusion 2200, Inc., S...

1. A pump cassette comprising:a rigid body comprising a frame portion, a base portion, a compliant membrane disposed substantially therebetween, two opposing edge sections, and an interface-facing surface;
a controllable fluid pathway defined at least in part by the base portion and the compliant membrane;
a first positioning feature on the frame portion and arranged substantially orthogonal to a general plane of the interface-facing surface, the first positioning feature configured to mechanically interact with a first corresponding positioning feature on a surface of a cassette recess of an infusion pump for positioning of the pump cassette within the cassette recess;
a second positioning feature on the frame portion, laterally separated from the first positioning feature, arranged substantially orthogonal to the general plane of the interface-facing surface, and configured to mechanically interact with a second corresponding positioning feature on the surface of the cassette recess of the infusion pump for positioning of the pump cassette within the cassette recess, wherein the second positioning feature comprises a protrusion on the frame portion within which a portion of the controllable fluid pathway is disposed; and
a slider coupled to the two opposing edge sections and longitudinally articulable with respect to the rigid body.

US Pat. No. 10,245,372

CLEANING INSTRUMENT FOR LARGE INTESTINE

WONJIN CO., LTD., Hwaseo...

1. A colonic irrigator comprising:a cleansing body (10) having a laid down egg shape, having a spray hole (12) formed at a lifted portion (11) provided on the upper part thereof and having a cleansing solution channel (13) formed therein to communicate with the spray hole (12); and
a connector (20) which has a screw part (21) formed at one side thereof so as to be connected to a shower hose (40), is bent at 90 degrees such that another side thereof is connected to a lower part of the cleansing body (10), and has a cleansing solution channel (23) formed therein to communicate with the cleansing solution channel (13) of the cleansing body (10),
wherein the cleansing body (10) and the connector (20) are integrated, and
wherein a water pressure regulating member is provided at a side of the cleansing body (10), wherein the water pressure regulating member comprises: a cylinder-shaped extension portion (15) extended from a longitudinal end of the cleansing body (10) and having a pressure regulating hole (16) at a side thereof; a pressure regulating channel (17) formed at the extension portion (15) and the cleansing body (10) to connect the cleansing solution channel (13) of the cleansing body (10) and the pressure regulating hole (16) formed at the extension portion (15), and a silicone band (18) connected to the extension portion (15) and regulating an opening of the pressure regulating hole (16).

US Pat. No. 10,245,371

ANASTOMOTIC DEVICE AND METHODS

1. A stent graft comprising:a sidewall port device configured for coupling the stent graft to an aperture in a tissue wall; and
a conduit configured to extend through the aperture in the tissue wall for transporting fluid when implanted, the side wall port device comprising a lattice inverted onto itself to form an inner tube disposed coaxially within an outer tube.

US Pat. No. 10,245,370

RENAL FAILURE THERAPY MACHINES AND METHODS INCLUDING CONVECTIVE AND DIFFUSIVE CLEARANCE

Baxter International Inc....

1. A renal failure therapy machine comprising:a blood cleaning filter;
a dialysis fluid circuit including a balance chamber, the balance chamber including a fresh dialysis fluid compartment configured to send fresh dialysis fluid to the blood cleaning filter and a used dialysis fluid compartment configured to receive used dialysis fluid from the blood cleaning filter;
a fresh dialysis fluid line in fluid communication with the fresh dialysis fluid compartment of the balance chamber and the blood cleaning filter; and
a flow restrictor in fluid communication with the blood cleaning filter, the flow restrictor configured to cause fresh dialysis fluid delivered from the fresh dialysis fluid compartment, through the fresh dialysis fluid line, to the blood cleaning filter to be pressurized so that a first amount of the fresh dialysis fluid performs convective clearance and a second amount of the fresh dialysis fluid performs diffusive clearance.

US Pat. No. 10,245,369

SYSTEMS AND METHODS FOR PRIMING HEMODIALYSIS USING DIALYSIS FLUID

Baxter International Inc....

1. A method for priming a hemodialysis treatment comprising:providing a disposable cassette including at least a portion of a dialysate circuit and at least a portion of a blood circuit;
placing a dialyzer in fluid communication with the dialysate circuit via a to-dialyzer dialysate line and a from-dialyzer dialysate line;
placing the dialyzer in fluid communication with the blood circuit via an arterial blood line and a venous blood line;
placing a source of dialysis fluid in fluid communication with the dialyzer;
priming the dialysate circuit with dialysis fluid from the source while both the to-dialyzer dialysate line and the from-dialyzer dialysate line are connected at their dialyzer ends to the dialyzer; and
priming the blood circuit with dialysis fluid from the source by actuating at least one valve provided by the disposable cassette.

US Pat. No. 10,245,368

INTEGRATED HYBRID BIO-ARTIFICIAL LIVER BIOREACTOR DESIGN AND METHOD THEREOF

INDIAN INSTITUTE OF TECHN...

1. A hybrid Bioartificial liver bioreactor comprising:at least three chambers adapted to be positioned as ax integrated and a single unit including:
a top chamber, provided with a first inlet/outlet port, comprising a plasma separation membrane configured to separate a blood stream received from a patient into plasma and blood cells;
a middle chamber, provided with a second inlet/outlet port to connect with the top or a bottom chamber, said middle chamber seeded with hepatocyte cells in a semi-interpenetrating supermacroporous cryogel;
the bottom chamber provided with a third inlet/outlet port to connect with the top or middle chambers, the bottom chamber configured for plasma collection and reintroduction of said plasma or part thereof to one of said top or middle chambers;
where said top and middle chambers are configured to be separated in position by a means for filtering, toxic compounds, and
where said middle and bottom chambers are separated by a means for trapping cellular material from leaking out of said bioreactor.

US Pat. No. 10,245,367

AMBULATORY LUNG ASSIST DEVICE WITH IMPLANTED BLOOD PUMP AND OXYGENATOR

HeartWare, Inc., Miami L...

1. A portable lung assist system, comprising:an implantable blood pump having a pump outlet and a pump inlet configured for communication with a circulatory system of a patient at an inlet location; and
an external and portable blood oxygenator having a blood inlet releasably connectable to the pump outlet and a blood outlet releasably connectable to the circulatory system of the patient at a return location; and
a bypass conduit connectable to the blood pump, wherein the oxygenator and the bypass conduit are in continuous fluid communication with the blood pump when the blood inlet is connected to the pump outlet.

US Pat. No. 10,245,366

IMPLANTABLE HEART TREATMENT SYSTEMS, DEVICES, AND METHODS

Elwha LLC, Bellevue, WA ...

1. A method of treating a heart with an implanted heart treatment device, comprising:generating, via a heart treatment device implanted within a body of a biological subject, one or more electric signals configured to stimulate one or more tissues of a heart within the body during a fibrillation event of the heart;
administering the one or more electric signals to the one or more tissues of the heart; and
delivering, via the heart treatment device, one or more non-oxygen cellular energy sources to one or more tissues of the heart, after the fibrillation event has proceeded for a duration sufficient to exhaust the myoglobin-based oxygen of the heart.

US Pat. No. 10,245,365

REPLENISIHING UREASE IN DIALYSIS SYSTEMS USING A UREASE INTRODUCER

Medtronic, Inc., Minneap...

1. A method, comprising the steps of:detecting an amount of urea directly or indirectly by measuring products proportional to an amount of urea in a sample in a dialysate downstream of a sorbent cartridge; wherein the sorbent cartridge contains urease and at least one or more other sorbent materials; and
supplying urease to the sorbent cartridge by a urease introducer if the amount of urea downstream of the sorbent cartridge is above a threshold, wherein the sorbent cartridge is adapted to receive an adjustable amount of urease, wherein the urease introducer comprises any one of a slideable tray and a door.

US Pat. No. 10,245,364

SAFETY APPARATUS FOR EXTRACORPOREAL BLOOD TREATMENT

Fresenius Medical Care De...

1. A blood purification device comprising:an extracorporeal blood circuit with a blood inflow to a dialysis unit for blood removed from a patient and a blood outflow from the dialysis unit for blood being guided back into the patient, wherein the dialysis unit comprises an inflow for a dialysis solution and a dialysate outflow,
a citrate anticoagulation apparatus, wherein citrate is supplied to the extracorporeal blood circuit at a citrate supply point upstream of the dialysis unit and a substitute medium dosing apparatus, wherein substitution medium is supplied at a substitution medium supply point downstream of the dialysis unit,
a control loop for controlling the acid-base balance of the blood, wherein bicarbonate is supplied to the blood by means of an aqueous bicarbonate-containing solution, wherein at least one measuring means for measuring a blood buffer parameter is associated with the control loop and upstream of the citrate supply point in the extracorporeal blood circuit, wherein the blood buffer parameter is selected from the group consisting of bicarbonate concentration and CO2 partial pressure, and wherein a signal corresponding to the measured actual value of the blood buffer parameter can be supplied to a control apparatus, which regulates the actual value of the blood buffer parameter via the supply of bicarbonate to a predeterminable intended value or intended value range,
at least one pH-measuring means, which is arranged upstream of the citrate supply point in the extracorporeal blood circuit, wherein a signal corresponding to the pH value can be supplied to an alarm apparatus, which triggers an alarm signal if a predeterminable pH value or a pH-value range is exceeded or undershot,
wherein the arrangement of the at least one measuring means for measuring a blood buffer parameter located upstream of the citrate supply point in the extracorporeal blood circuit and the at least one pH-measuring arranged upstream of the citrate supply point are configured to detect and prevent or treat disturbances of the acid-base balance during an extracorporeal blood purification selected from the group of compensated acidosis, non-compensated acidosis, compensated alkalosis and compensated or non-compensated alkalosis,
at least one additional measuring means for measuring a blood buffer parameter that is associated with the control loop and arranged downstream of the dialysis unit and upstream of the substitution medium supply point in the extracorporeal blood circuit, and
at least one additional pH-measuring means that is arranged downstream of the substitution medium supply point in the extracorporeal blood circuit, wherein a signal corresponding to the pH value can be supplied to the alarm apparatus, which triggers an alarm signal if a predeterminable pH value or pH-value range is exceeded or undershot.

US Pat. No. 10,245,363

CATHETER-BASED PUMP FOR IMPROVING ORGAN FUNCTION

Stanton J. Rowe, Newport...

1. A method for improving renal function of a patient, comprising:mechanically occluding an inferior vena cava downstream of a renal vein ostium to form an upstream region and a downstream region of the inferior vena cava; and
mechanically pumping blood through the inferior vena cava from the upstream region to a discharge location in the downstream region while the inferior vena cava is occluded, wherein the blood remains in the inferior vena cava while being mechanically pumped.

US Pat. No. 10,245,362

BLOOD PUMP FOR TREATMENT OF BRADYCARDIA

HeartWare, Inc., Miami L...

1. A ventricular assist device comprising:a rotary pump configured to be implantable in fluid communication with a ventricle and an artery of a subject to assist blood flow from the ventricle to the artery;
a pump drive circuit for applying power to the pump;
a pump drive circuit to control the speed of the pump;
one or more sensors for sensing one or more electrogram signals in a patient;
a signal processing circuit in communication with the sensors and the pump drive circuit, the signal processing circuit being configured to receive the electrogram signals and:
determine an impending onset or absence of a bradycardia arrhythmia based on the electrogram signals from the sensors;
during the impeding onset of a bradycardia arrhythmia, determine the impending onset of sinus bradycardia or heart block;
control power supplied to the pump from the pump drive circuit so as to control the speed of the pump and:
operate the pump in a normal sinus rhythm mode in the absence of an arrhythmia;
operate the pump in a first modified mode of operation during the impending onset of heart block or sinus bradycardia.

US Pat. No. 10,245,361

IMPELLER SUSPENSION MECHANISM FOR HEART PUMP

TC1 LLC, Pleasanton, CA ...

1. A centrifugal blood pump, comprising:a housing that defines an inlet passage, a chamber, and an outlet passage;
an impeller rotatably positioned in the chamber to transfer blood from the inlet passage through the chamber and to the outlet passage, the impeller comprising an inner portion and an outer portion;
a plurality of impeller magnets embedded in the impeller such that the impeller and the plurality of impeller magnets rotate together within the chamber, the plurality of impeller magnets comprising an inner impeller magnet and an outer impeller magnet relative to a central axis of the impeller;
a motor to control movement of the impeller in the chamber, the motor being positioned adjacent the chamber and separated from the chamber by a partition member;
an inner annular magnetic member embedded in a wall of the housing opposite the partition member; and
an outer annular magnetic member embedded in the wall of the housing opposite the partition member, wherein a first net magnetic force between the inner annular magnetic member and the inner impeller magnet exhibits greater attraction than a second net magnetic force between the outer annular member and the outer impeller magnet.

US Pat. No. 10,245,360

CONNECTOR RING CLAMP AND ASSOCIATED METHODS OF USE

HeartWare, Inc., Miami L...

1. A connector ring assembly comprising:an annular wall defining a first opening adapted to receive a conduit, the first opening having an opening axis;
a clamp having a body and a first arm and a second arm coupled to each other by the body, the first arm and the second arm defining a distance therebetween extending away from body and entirely along the first arm and the second arm, the clamp engaging the annular wall and defining a second opening co-axial with the first opening, the clamp operably configured to rotate relative to the annular wall in a first state and remain fixed relative to the annular wall in a second state, and the distance between the first arm and second arm in the first state being greater than the distance between the first arm and second arm in the second state;
an actuator disposed substantially parallel with respect to the annular wall and the clamp, the actuator adapted to transition the clamp between the first state and the second state; and
an actuator receiver defining an actuator opening including the actuator disposed therein, the actuator opening having an actuator axis generally parallel to the opening axis.

US Pat. No. 10,245,359

SUCTION AND IRRIGATION APPARATUS WITH ANTI-CLOGGING CAPABILITY

Peter L. Bono, Bingham F...

1. A handheld tool for providing irrigation and suction for surgical procedures comprising:a housing, comprising at least one valve assembly, said at least one valve assembly including a suction terminal for fluid connection to a source of suction, said at least one valve assembly including an irrigation terminal for fluid connection to a source of pressurized irrigation fluid, said at least one valve assembly including an outlet terminal for connection to a cannula, said cannula extending outwardly from said housing, said valve assembly including a flush button, progressive movement of said flush button in a first direction causes progressive restriction of said suction inwardly through said cannula and simultaneously provides progressive flow of said pressurized irrigation fluid outwardly through said cannula, whereby progressive movement of said flush button in a second direction progressively restores flow of said suction inwardly through said cannula and simultaneously and progressively restricts flow of said pressurized irrigation fluid outwardly through said cannula.

US Pat. No. 10,245,358

EVAPORATIVE BODY-FLUID CONTAINERS AND METHODS

KCI Licensing, Inc., San...

1. A system for treating a tissue site with reduced pressure, the system comprising:a manifold configured to be placed proximate to the tissue site;
a sealing member configured to cover the manifold and the tissue site to form a sealed space;
a reduced-pressure source configured to be fluidly coupled to the sealed space; and
a container for receiving body fluids from the tissue site, the container comprising:
at least one wall having a plurality of apertures,
a liquid-impermeable, vapor-permeable material defining a portion of an interior space of the container, wherein the liquid-impermeable, vapor-permeable material is coupled to the at least one wall and covers the plurality of apertures,
a fluid inlet fluidly coupled to the interior space and configured to be fluidly coupled to the sealed space,
a fluid outlet fluidly coupled to the interior space and configured to be fluidly coupled to the reduced-pressure source, wherein the fluid outlet is separate from the plurality of apertures, and
a filter disposed in the fluid outlet;
wherein the liquid-impermeable, vapor-permeable material is adapted to come into contact with the body fluids received in the container and is adapted to retain the body fluids received in the container.

US Pat. No. 10,245,357

SYSTEM AND KIT FOR THE COLLECTION AND PROCESSING OF AMNIOTIC FLUID AND PLACENTAL ASPIRATE

PENSARA, INC, Richmond, ...

6. A kit for collection, separation and reuse of cellular material from amniotic fluid and placental aspirate comprising:a canister having a coil, wherein the coil is hollow and has a tear drop shaped cross-section, and a cellular accumulation chamber, said cellular accumulation chamber having a port, said canister having an inlet and an outlet, said coil connected to said inlet and to said outlet, said canister suitable for attachment to a vacuum line;
a syringe having a needle suitable for insertion into said port of said cellular accumulation chamber; and
a dual-chambered applicator suitable for receiving cellular material from said syringe.

US Pat. No. 10,245,355

MODIFICATION OF SURFACES FOR FLUID AND SOLID REPELLENCY

President and Fellows of ...

1. An article having a slippery surface, comprising:a substrate comprising an anchoring layer, the anchoring layer comprising:
anchoring molecules comprising a head group attached to the substrate and a functional tail group directly or indirectly attached to the head group; and
a crosslinking agent that crosslinks the anchoring molecules to one another;
a lubricating layer comprising a lubricating liquid having an affinity for the functional tail group and disposed over the anchoring layer, wherein the anchoring layer and the lubricating layer are held together by non-covalent attractive forces,
wherein the anchoring layer and the lubricating layer form a slippery surface configured and arranged for contact with a material that is substantially immiscible with the lubricating liquid,
wherein the slippery surface is omniphobic, and
wherein the article is substantially free of anchoring molecules not bound to the substrate, unreacted crosslinking agent, and reaction byproducts between the anchoring molecules and the crosslinking agent.

US Pat. No. 10,245,353

HYDROPHILIC ELECTROSPINNING BIOLOGICAL COMPOSITE STENT MATERIAL USED FOR TISSUE REGENERATION AND PREPARATION METHOD AND APPLICATION THEREOF

1. A hydrophilic electrospinning biological composite scaffold material, wherein it is prepared by blending an aqueous solution of fibrinogen and L-arginine or hydrochloride thereof with a P(LLA-CL) solution using an electrospinning technique, wherein the hydrophilic electrospinning biological composite scaffold material has an equilibrium contact angle, and the equilibrium contact angle thereof is less than 55°.

US Pat. No. 10,245,352

CATHETER SHAFT HAVING HIGH STRENGTH AND FLEXIBILITY

ABBOTT CARDIOVASCULAR SYS...

1. An elongated shaft for a catheter, comprising a single layer biaxially oriented nonporous thermoplastic polymer tubular member having a Shore durometer hardness of less than about 75D.

US Pat. No. 10,245,346

ION EXCHANGE ABSORBENT SYSTEMS, APPARATUSES, AND METHODS

KCI Licensing, Inc., San...

1. A fiber, comprising:an absorbent core; and
a filter layer surrounding the absorbent core and comprising an ion-exchange media adapted to reduce an ionic concentration of a fluid prior to the fluid coming into contact with the absorbent core;
wherein the ion-exchange media comprises cation-exchange media and anion-exchange media that are dispersed throughout the filter layer.

US Pat. No. 10,245,345

ATOMIZATION SEPARATING AND SILENCING APPARATUS AND METHOD

1. A system operable as a diffuser, the system comprising;a reservoir, operable to contain a liquid and defining axial, radial, and circumferential directions mutually orthogonal to one another;
a first chamber and a second chamber separated by a wall therebetween as a barrier to flow directly therebetween in the axial direction;
a nozzle operably connected to introduce into the first chamber a flow comprising droplets of the liquid, drawn from the reservoir, entrained in air; and
a separator, comprising a channel, simultaneously progressing axially and circumferentially through the wall to conduct the flow from the first chamber into the second chamber.

US Pat. No. 10,245,344

DEODORIZING CATCH TRAY FOR HAND DRYERS

1. A device for catching water drippings below a hand dryer, comprising:a catch tray adapted to mount to a wall, the catch tray defining a recess in a top surface thereof, the catch tray including a base tray and a back wall, wherein a first recess portion is disposed in a top surface of the base tray and a second recess portion, continuous with the first recess portion, is disposed in an angled front face of the back wall;
a deodorizing screen removably disposed in the recess, the deodorizing screen comprising a first screen portion disposed in the first recess portion and a second screen portion, at an angle to the first screen portion and continuous therewith, disposed in the second recess portion; and
a sponge disposed in the recess below the first screen portion;
wherein the catch tray does not include a cover such that the deodorizing screen is at all times exposed and visible from above the catch tray.

US Pat. No. 10,245,343

SCENTED WAFER

1. A scented wafer for emitting a scent to a surrounding open environment,said scented wafer being uncovered to present a large surface area for emission of scent to the surrounding open environment, and comprising a body material formed of a heat-resistant fibrous material having a predetermined porosity resulting from a selected denier and length of fibers; and
a scented material impregnated into the body material and constructed to melt and release a scent when exposed to heat of a predetermined temperature that exceeds the temperature of the surrounding open environment and a melting point of the scented material;
wherein the body material retains structural integrity and does not melt at the predetermined temperature to facilitate the reuse or replacement of the wafer, and
the body is formed with numerous edges and grooves to create a large surface area for emission of the scented material when heated and melted.

US Pat. No. 10,245,342

ANTIMICROBIAL DEVICES FOR USE WITH MEDICAL DEVICES AND RELATED ASSEMBLIES AND METHODS

Health Line International...

1. An antimicrobial device for use in disinfecting at least a portion of a medical device, the antimicrobial device comprising:a monolithic, nonporous flexible housing formed from a flexible material, the flexible housing having a first open end forming an access port in the antimicrobial device to a cavity formed in the flexible housing for receiving the at least portion of the medical device within the antimicrobial device, a second closed end opposing the first open end, and a longitudinal axis extending between the first open end and the second closed end, the first open end being defined by a furthest longitudinal extent of the housing at a first longitudinal end of the housing, wherein the cavity in the flexible housing and an outer surface of the flexible housing are both tapered along the longitudinal axis of the flexible housing;
an antimicrobial substance contained within the cavity in an amount sufficient to disinfect at least a portion of the medical device;
a plurality of flexible concentric protrusions, at least one flexible protrusion of the plurality of flexible protrusions positioned at and directly adjacent to the first open end and extending around and into the cavity from an inner surface of the flexible housing in a direction perpendicular to the longitudinal axis of the flexible housing, wherein the at least one flexible protrusion is configured to directly engage with and secure the antimicrobial device to the at least a portion of the medical device in a manner allowing for the antimicrobial substance to make surface contact with the at least a portion of the medical device, wherein each successive concentric protrusion of the plurality of flexible concentric protrusions has a diameter that is less than a diameter of an adjacent concentric protrusion of the plurality of flexible concentric protrusions, wherein the at least one flexible protrusion and the flexible housing comprise a single unitary structure formed by injection molding; and
a nonporous sealing member adhered to the first open end, the sealing member and the nonporous flexible housing configured to entirely contain the antimicrobial substance within the cavity, while only enabling the antimicrobial substance to pass through the access port at the first open end after the nonporous sealing member has been removed from the housing.

US Pat. No. 10,245,341

ROOM AND AREA DISINFECTION UTILIZING PULSED LIGHT WITH MODULATED POWER FLUX AND LIGHT SYSTEMS WITH VISIBLE LIGHT COMPENSATION BETWEEN PULSES

Xenex Disinfection Servic...

1. A method for reducing bacterial contamination on surfaces in an enclosed space which is suitable for human occupancy, wherein the method comprises:generating pulses of light at a frequency greater than approximately 20 Hz from a germicidal light source of a disinfection apparatus that is arranged in an enclosed space which is suitable for human occupancy; and
projecting the pulses of light to surfaces in the enclosed space at least 1.0 meter from the disinfection apparatus, wherein the pulses of light generated by the germicidal light source comprise a pulse duration and an energy flux sufficient to generate a power flux between approximately 200 W/m2 and approximately 5000 W/m2 of ultraviolet light in the wavelength range between 200 nm and 320 nm at the surfaces.

US Pat. No. 10,245,340

ROOM AND AREA DISINFECTION UTILIZING PULSED LIGHT WITH MODULATED POWER FLUX AND LIGHT SYSTEMS WITH VISIBLE LIGHT COMPENSATION BETWEEN PULSES

Xenex Disinfection Servic...

1. A disinfection apparatus, comprising:a germicidal pulsed light source arranged within the disinfection apparatus such that germicidal light generated from the germicidal pulsed light source is projected exterior to the disinfection apparatus;
trigger voltage circuitry for applying a trigger voltage to the germicidal pulsed light source at a set frequency greater than approximately 20 Hz;
power supply circuitry;
one or more electrical charge storage devices coupled to the power supply circuitry and to the germicidal pulsed light source;
pulse duration circuitry coupled between the one or more electrical charge storage devices and the germicidal pulsed light source, wherein the one or more electrical charge storage devices and the pulse duration circuitry are configured to discharge a set amount of stored energy in a set amount of time such that energy flux of ultraviolet light in the wavelength range between 200 nm and 320 nm generated at the germicidal pulsed light source is between approximately 20 J/m2 and approximately 1000 J/m2;
an occupancy sensor for determining presence of an individual in a region extending at least 1.0 meter from the disinfection apparatus;
a processor; and
program instructions executable by the processor for inhibiting and terminating the generation of light from the germicidal pulsed light source upon the occupancy sensor detecting presence of an individual.

US Pat. No. 10,245,339

APPARATUS AND METHOD OF STERILIZING LUMENS IN MEDICAL INSTRUMENTS

19. A method of sterilizing an internal surface of a lumen in a medical instrument comprising:a) providing an apparatus including an elongated UVC light guide having a central longitudinal axis, a distal end portion and a proximal end portion, said distal end portion including a reflective attachment comprising a sleeve or tube and at least one reflective surface, said sleeve or tube being secured to said distal end portion of said UVC light guide and being formed of a material through which UVC light can readily pass, said at least one reflective surface being located within said sleeve or tube and extending at an angle to said central longitudinal axis and being configured for directing UVC light radially outward from said central longitudinal axis through said sleeve or tube;
b) coupling a source of UVC light to said proximal end portion of said elongated UVC light guide, said source of UVC light including at least one LED for producing UVC light when said at least one LED is energized;
c) inserting said UVC light guide within said lumen of said instrument;
d) energizing said source of UVC light to produce UVC light, whereupon said UVC light guide carries said UVC light from said source of UVC light internally down said UVC light guide to said reflective attachment from whence said UVC light is directed radially outward through said sleeve or tube to impinge said internal surface of said lumen to sterilize that surface; and
e) moving said UVC light guide through said lumen while said source of UVC light is producing said UVC light to thereby sterilize the length of said internal surface of said lumen.

US Pat. No. 10,245,338

ULTRAVIOLET DIFFUSIVE ILLUMINATION

Sensor Electronic Technol...

1. A system comprising:an illuminator including:
a reflective cavity comprising a plurality of surfaces, wherein at least one of the plurality of surfaces is formed of a first material configured to reflect at least 70% of ultraviolet radiation, wherein the first material is patterned to include a plurality of diffusive elements, and wherein at least one of the plurality of surfaces is formed of a second material configured to transmit at least 30% of the ultraviolet radiation through the second material and out of the reflective cavity and reflect at least 10% of the ultraviolet radiation;
a plurality of ultraviolet radiation sources located within the reflective cavity; and
a set of optical elements located within the reflective cavity and configured to distribute the ultraviolet radiation within the cavity before the ultraviolet radiation exits the reflective cavity through the second material, wherein each optical element is located a distance away from an ultraviolet radiation source, and wherein the distance is approximately equal to a diameter of the corresponding ultraviolet radiation source and is configured to increase uniformity of the ultraviolet radiation exiting the reflective cavity;
a feedback component including a sensor configured to acquire fluorescence data corresponding to fluorescent visible radiation emitted from a surface radiated by the illuminator; and
a computer system for operating the plurality of ultraviolet radiation sources based on the fluorescence data.

US Pat. No. 10,245,337

MULTIFUNCTION LIGHT-EMITTING DIODE LIGHTING APPARATUS

SEOUL VIOSYS CO., LTD., ...

1. A multifunction Light-Emitting Diode (LED) lighting apparatus installed on a product, including:a module including a substrate having a first surface and a second surface opposite to the first surface;
at least one lighting LED disposed on the first surface of the substrate;
at least one ultraviolet (UV) LED disposed on the first surface of the substrate; and
a cover disposed to face the substrate at a specific interval from the substrate and configured to cover the at least one lighting LED and the at least one UV LED,
wherein the at least one lighting LED and the at least one UV LED are integrally disposed over the substrate to form the module,
wherein the module is disposed on the product such that the second surface of the substrate is installed on an inside wall of the product,
wherein the module is configured to radiate ultraviolet rays to a fluid in an interior of the product and provide illumination to the interior of the product, and
wherein the cover includes a first region facing the at least one lighting LED and a second region facing the at least one UV LED,
wherein the cover further includes a light diffusion unit formed in the first region and configured to diffuse light emitted from the lighting LED,
wherein the cover further includes an opening unit formed in the second region such that UV rays radiated from the light UV LED are directed to the product and the cover further includes a material covering the opening unit and having a property to allow the UV rays to pass through the material, and
wherein the cover further includes a partition that partitions the first region and the second region.

US Pat. No. 10,245,336

SYSTEM FOR HANDLING STERILISATION OF THIN-BODY FLEXIBLE CONTAINERS (POUCH)

Guala Pack S.P.A., (IT)

1. Method of sterilisation of flexible pouches, comprising the steps of:producing a plurality of pouches, wherein each pouch comprises a container body formed by walls made of flexible film and a spout comprising an entrance portion with an inlet and a tube with an outlet, said spout being sealingly applied to the container body so as to protrude outside of it with at least a section of the tube;
providing a plurality of sacrificial closures reversibly applicable to the outlet mouth of the spout;
applying, sealingly and reversibly, the sacrificial closure to the outlet of the spout, thereby obtaining provisionally closed non-filled pouches to be sterilised;
loading a plurality of provisionally closed non-filled pouches to be sterilised on a transport device for collective transport;
forming a transport group, containing a plurality of transport devices, each carrying the provisionally closed non-filled pouches to be sterilised, stacked;
transporting the transport group from the site of the producer subject to a steriliser subject;
performing a sterlisation of the entire transport group loaded with provisionally closed non-filled pouches, by ionising radiation;
picking the sterilised provisionally closed non-filled pouches from the transport device and sending them in succession to a sterile chamber;
for each sterilised provisionally closed non-filled pouch, making at least a portion of the tube provided with the sacrificial closure to pass through the sterile chamber;
during said passing through of the sterile chamber, separating the sacrificial closure from the tube, filling the sterilised open pouch and applying a tamper-proof cap to the tube to close the pouch.

US Pat. No. 10,245,335

STERILIZING METHOD AND APPARATUS

Turbett Surgical LLC, Ro...

1. A sterilizing cabinet assembly, comprising:(a) a cabinet having an access port;
(b) a door connected to the cabinet, the door moveable between an open position permitting passage through the access port to an interior of the cabinet and a closed position precluding passage through the access port;
(c) at least one of the cabinet and the door having a vent port;
(d) a primary filter overlying the vent port and forming a sealed interface with an adjacent portion of the one of the cabinet and the door;
(e) a secondary filter overlying at least a portion of the primary filter; and
(f) a filter holder moveable between an open position and a closed position and configured to hold the primary and secondary filters, the filter holder having a first filter holder section overlying the primary filter and a second filter holder section overlying the secondary filter, wherein the secondary filter is separable from the filter holder and the primary filter when the second filter holder section is in the open position, while maintaining the sealed interface between the primary filter and the adjacent portion of the one of the cabinet and the door.

US Pat. No. 10,245,334

REFRACTION TECHNOLOGY SYSTEM

Richard J. Barrett, Roth...

1. A method for modifying the monoatomic oxygen level in a fluid, comprising:(a) providing a first electrode defining a first conductive surface spaced from a second electrode defining a second conductive surface;
(b) providing a porous divider positioned intermediate the first electrode and second electrode and defining a first fluid treatment chamber with the first conductive surface and a second fluid treatment chamber with the second conductive surface;
(c) providing a positive charge to the first electrode and a negative charge to the second electrode;
(d) flowing an initial fluid having an initial oxidation reduction potential (ORP) value from an inlet to the first chamber and the second chamber via an end cap defining a first fluid inlet to the first chamber and a second fluid inlet to the second chamber, wherein the first fluid inlet is configured to allow a greater volume of fluid per unit time to the first chamber than the second fluid inlet allows to the second chamber, thereby modifying the monoatomic oxygen level of the initial fluid in both chambers; and
(e) collecting positive oxygen fluid having a positive ORP value greater than the initial ORP value from the first chamber and negative oxygen fluid having a negative ORP value lower than the initial ORP value from the second chamber.

US Pat. No. 10,245,333

PLASMA GENERATING APPARATUS AND TREATMENT METHOD USING THE SAME

ELECTRONICS AND TELECOMMU...

1. A plasma generating apparatus comprising:a housing configured to provide an inner space in which plasma is generated;
a ground electrode coupled to one side of the housing;
a power electrode coupled to the other side of the housing; and
a controller configured to control a generation mode of the plasma,
wherein the generation mode comprises:
a first mode in which the plasma is provided to a target to be processed while generating the plasma; and
a second mode in which the plasma is generated in the housing, and then the generated plasma is provided to the target to be processed.

US Pat. No. 10,245,332

CONTRAST AGENTS FOR APPLICATIONS INCLUDING PERFUSION IMAGING

Lantheus Medical Imaging,...

1. A method of imaging cancer in a subject, comprising:administering to a subject with cancer a contrast agent which comprises an imaging moiety and a compound bound to the imaging moiety, scanning the patient using diagnostic imaging to produce an image of at least a portion of the cancer, wherein the contrast agent has a structure as in Formula (II),
wherein:J is selected from N(R27) S, O, C(?O), C(?O)O, NHCH2CH2O, a bond, or C(?O)N(R27);
K and L, when present, are independently selected from hydrogen, alkoxyalkyl, alkyloxy, aryl, alkyl, heteroaryl, and an imaging moiety, each of which is optionally substituted;
M is selected from hydrogen, alkoxyalkyl, alkyloxy, aryl, alkyl, heteroaryl, and an imaging moiety, each of which is optionally substituted, or
L and M, together with the atom to which they are attached, form a ring, optionally substituted;
Q is halo or haloalkyl;
n is 0, 1, 2, or 3;
R21, R22, R23, R24, R25, R26, and R27 are independently selected from hydrogen, alkyl,
optionally substituted, and an imaging moiety;
R29 is alkyl, optionally substituted; and
Y is selected from a bond, carbon, and oxygen; provided that when Y is a bond, K and L are
absent and M is selected from aryl and heteroaryl, each of which is optionally substituted; and
provided that when Y is oxygen, K and L are absent and M is selected from hydrogen, alkoxyalkyl,
aryl, alkyl, and heteroaryl, each of which is optionally substituted,
wherein at least one imaging moiety is present in Formula (II) and is 18F.

US Pat. No. 10,245,330

COMPOSITIONS AND METHODS FOR IMAGING

The Regents of the Univer...

1. A method of detecting hydrogen peroxide in a cell, tissue, or organ, or extracellularly in an individual, the method comprising:a) administering to the individual a compound of the formula:

wherein Z is heteroaryl group, wherein the substituted aryl or heteroaryl group comprises one or more R1 substituent groups each independently selected from a halogen, cyano, nitro, trihalomethyl, alkoxy, aryloxy, alkyl, aryl, heterocycle, thiol, thioether, acyl and hydroxyl, wherein the compound includes one or more isotopically labeled atoms capable of being hyperpolarized by dynamic nuclear polarization at one or more positions selected from the keto carbon and any atom of the substituted aryl or heteroaryl group; and
b) detecting a signal produced by the compound upon reaction with hydrogen peroxide, wherein the compound is hyperpolarized and the detecting is by hyperpolarized magnetic resonance imaging.

US Pat. No. 10,245,329

COMPOSITION HAVING DYE AND CONJUGATE OF POLYETHYLENEGLYCOL AND ADDITIVE AND CONTRAST AGENT FOR PHOTOACOUSTIC IMAGING HAVING THE SAME

CANON KABUSHIKI KAISHA, ...

1. A contrast agent suitable for photoacoustic imaging, comprising: a compound represented by formula (1), (5), (6), or (7); and an additive, which interacts with the compound, wherein the additive is at least one selected from the group consisting of an ?-cyclodextrin, a ?-cyclodextrin, a hydroxypropyl-?-cyclodextrin, and a ?-cyclodextrin:
wherein R301 to R312 are each independently selected from the group consisting of a hydrogen atom, a halogen atom, —PO3T301, a substituted or unsubstituted phenyl group, thiophene group, or pyridinyl group and a linear or branched alkyl group having 1 to 18 carbon atoms;
T301 is selected from the group consisting of a hydrogen atom, a sodium atom and a potassium atom;
R31 to R34 are each independently selected from the group consisting of a hydrogen atom and a linear or branched alkyl group having 1 to 18 carbon atoms;
A31, B31 and B32 each independently represent a linear or branched alkylene group having 1 to 18 carbon atoms;
L31 to L37 are each independently selected from the group consisting of CH and CR35 and may form a 4- to 6-membered ring;
R35 is selected from the group consisting of a linear or branched alkyl group having 1 to 18 carbon atoms, a halogen atom, a substituted or unsubstituted phenyl group, pyridinyl group, or benzyl group, ST302 and a linear or branched alkylene group having 1 to 18 carbon atoms;
T302 is selected from the group consisting of a linear or branched alkyl group having 1 to 18 carbon atoms, a substituted or unsubstituted phenyl group and a linear or branched alkylene group having 1 to 18 carbon atoms;
Q31 is selected from the group consisting of —CONT31-, —NT31CO—, —NT31(C?O) NT31-, —NT31(C?S) NT31-, —NT31(C?O)O—, —O—, —S—, —S(?O)2NT31-, —OP(?O)(OT31)O—, —S—S—, —CT31=N—, —CT31=N—NH—, —CT31=N—O—, —CT31=N—NH—O—, —CONT31-R37—(C?O)O—, —CONT31-R37—CONT31-, formula (2) and formula (3);
T31 is selected from the group consisting of a hydrogen atom and an alkyl group having 1 to 5 carbon atoms;
R37 is selected from the group consisting of —CH(CO2T37)-, —CH(CH2CO2T37)- and a linear or branched alkylene group having 1 to 18 carbon atoms;
T37 is selected from the group consisting of a hydrogen atom, a sodium atom, a potassium atom and an alkyl group having 1 to 5 carbon atoms;
R38 is selected from the group consisting of an alkyl group having 1 to 18 carbon atoms, a hydrogen atom, —OCH3, —NH2, —OH, —CO2T38, —S(?O)2OT38, —P(?O)(OT38)2 and —OP(?O)(OT38)2;
T38 is selected from the group consisting of a hydrogen atom, a sodium atom and a potassium atom;
R39 is selected from the group consisting of a hydrogen atom, —OCH3, —NH2, —OH, —S(?O)2OT39, —CO2T39, —P(?O)(OT39)2, —CONH—CH(CO2T39)-CH2(C?O)OT39, —CONH—CH(CO2T39)-CH2CH2(C?O)OT39 and —OP(?O)(OT39)2;
T39 is selected from the group consisting of a hydrogen atom, a sodium atom and a potassium atom;
q is an integer from 1 to 20;
n is an integer from 2 to 250:

US Pat. No. 10,245,328

GADOLINIUM COMPLEX COMPRISING DO3A-TRANEXAMIC ACID CONJUGATE

KYUNGPOOK NATIONAL UNIVER...

1. A DO3A-tranexamic acid compound having a structure of a following chemical formula 1, or an ester compound thereof:
where R is H, NH2 or CONN (CH2)2NH2.

US Pat. No. 10,245,326

AMANTADINE, MEMANTINE, AND RIMANTADINE CONJUGATES AND A PHARMACEUTICAL COMPOSITION FOR TREATMENT OF NEURONAL DISORDERS

1. A method of treating Parkinson's disease, the method comprising:administration to subject having Parkinson's disease, a therapeutically effective amount of an amantadine analog conjugate compound having the formula (II):
where R1 in each occurrence is independently H, or C1-C4 alkyl; R2 is a nullity or CH—CH3, R3 is a nullity or C(O)—R6—NH; R6 is C2-C6 alkyl, (CH2CH2—O)n, or (CH(OH)CH2)n; n is an integer of between 1 and 4; R4 is a nullity or NH—R6—C(O); and R5 is a moiety capable of crossing the blood brain barrier and is as a free compound is one of: serotonin, dopamine, blood brain barrier (BBB) peptide, membrane translocating peptide, TAT peptides, endocannabinoids, bradykinin, beta-endorphin, bombesin, calcitonin, cholecystokinin, an enkephalin, dynorphin, insulin, gastrin, substance P, neurotensin, glucagon, secretin, somatostatin, motilin, vasopressin, oxytocin, prolactin, thyrotropin, an angiotensin, galanin, neuropeptide Y, thyrotropin-releasing hormone, gonadotropnin-releasing hormone, growth hormone-releasing hormone, luteinizing hormone, vasoactive intestinal peptide transferrin, glucosyl ester, lactic acid, leucine, tryptophan, glutamic acid.

US Pat. No. 10,245,325

METHODS AND COMPOSITIONS FOR THE SUSTAINED RELEASE OF CHROMIUM

JDS Therapeutics, LLC, P...

1. A composition comprising:a chromium complex comprising:
an amount of a fast-acting chromium complex; and
an amount of a slow-acting chromium complex; wherein the fast-acting chromium complex is absorbed more quickly by an individual to whom it is administered than the slow-acting chromium complex;
wherein the amount of a fast acting chromium complex and the amount of the slow-reacting chromium complex are formulated to have a molar ratio of chromium between 1:10 and 10:1.

US Pat. No. 10,245,323

DRUG DEVICE CONFIGURED FOR WIRELESS COMMUNICATION

Pop Test Abuse Deterrent ...

1. A method for treatment of withdrawal from narcotics and subsequent prevention of relapse of narcotic use in a patient in need of such treatment, said method comprising:(a) forming an ingestible drug delivery device by a device manufacturer, said ingestible drug delivery device comprising:
a capsule body comprising:
a bioactive substance module comprising a container for holding a volume and/or quantity of bioactive substance therein and a microactuator for dispensing said bioactive substance from said container to a location outside of said capsule body, wherein said bioactive substance is a composition comprising:
i) a first therapeutic agent which is a GCR antagonist, or pharmaceutically acceptable salts thereof;
ii) separated from the first therapeutic agent, at least one additional therapeutic agent(s) selected from the group consisting of opioid analgesics and combinations thereof; and
iii) at least one pharmaceutically acceptable carrier, wherein the first therapeutic agent and said at least one additional therapeutic agent(s) are each present in an amount which, in combination, is a therapeutically effective amount for treatment of withdrawal from narcotics and subsequent prevention of relapse of narcotic use in a patient in need of such treatment;
an electronics module, coupled to said bioactive substance module, said electronics module comprising a processor, a transponder and a memory, said memory configured for storing data related to said bioactive substance;
a power source coupled to said bioactive substance module and said electronics module;
(b) establishing a unique device ID in said memory by the manufacturer and setting a first flag in said memory by the manufacturer;
(c) conveying said ingestible drug delivery device to a pharmacist, the pharmacist communicating with said ingestible drug delivery device using a programming terminal to store data related to the pharmacist and a patient ID authorized to ingest said ingestible drug delivery device in said memory and to set a second flag in said memory;
(d) selecting a patient in need of treatment of withdrawal from narcotics and subsequent prevention of relapse of narcotic use;
(e) administering said at least one ingestible delivery device to the patient based on need of treatment of withdrawal from narcotics and subsequent prevention of relapse of narcotic use, the patient having a patient interface device that communicates with said ingestible drug delivery device to provide said patient ID to said ingestible drug delivery device;
(f) analyzing, by said processor, to determine:(i) that said first flag is set;(ii) that said second flag is set; and(iii) that said patient ID provided by said patient interface device matches said patient ID provided by the pharmacist; and(g) dispensing said at least one bioactive substance to the patient only if said first and second flags are set and said patient ID provided by said patient interface device matches said patient ID provided by the pharmacist and disabling the dispensing of said at least one bioactive substance if either one of said first or second flags is not set or if no match is determined by said processor between said patient ID provided by said patient interface device and said patient ID provided by the pharmacist; and
wherein subsequent to the administration, the patient withdrawal from narcotics is treated and subsequent relapse of narcotic use is prevented.

US Pat. No. 10,245,322

NANOSTRUCTURED CARRIERS FOR GUIDED AND TARGETED ON-DEMAND SUBSTANCE DELIVERY

The Regents of the Univer...

1. A nanostructure device for carrying a payload, comprising:an interior particle structure that includes an opening to an internal cavity of the interior particle structure;
an exterior shell structure at least partially formed on an exterior surface of the interior particle structure;
a plurality of magnetic nanoparticles within the exterior shell structure;
a functionalization layer on a surface of the internal cavity capable of chemically attaching a molecular payload to the interior particle structure,
wherein the magnetic nanoparticles are structured to interact with an external magnetic field to magnetically steer the nanostructure device; and
a capping particle attached to the interior particle structure to cover the opening and enclose the molecular payload within the internal cavity, wherein attachment of the capping particle to the interior particle structure allows controllable movement of the capping particle to expose the opening based on a release stimulus, wherein the capping particle is attached to the interior particle structure by molecular self-assembly of a self-assembled monolayer (SAM) formed on the surface of the capping particle, or by a nucleic acid having two strands of a complementary sequence of nucleotides.

US Pat. No. 10,245,296

COMPOSITIONS INCLUDING GINGER FOR THE AMELIORATION OR PREVENTION OF INFLAMMATORY CONDITIONS

Colgate-Palmolive Company...

1. A method for treating inflammation or an inflammatory disorder in a companion animal in need thereof, comprising:measuring a baseline level of expression of one or more inflammatory biomarkers in the companion animal in need thereof;
treating the companion animal in need thereof by administering to the companion animal a pet food composition comprising an effective amount of ginger to treat the inflammation or inflammatory disorder in the companion animal, wherein the inflammatory disorder is arthritis; and
measuring a change in the level of expression of the one or more inflammatory biomarkers relative to the baseline level of expression in the companion animal in need thereof, thereby indicating treatment of the inflammation or the inflammatory disorder,
wherein the companion animal is a cat, and wherein measuring the change in the level of expression of the one or more biomarkers relative to the baseline level of expression consists of measuring an increase in biomarker C-propeptide of type II collagen (CPII).

US Pat. No. 10,245,285

BLOOD PLASMA AND PLASMA FRACTIONS AS THERAPY FOR TUMOR GROWTH AND PROGRESSION

Alkahest, Inc., San Carl...

1. A method of treating a subject for thymic cancer, the method comprising:administering an effective amount of a blood plasma product to the subject diagnosed with thymic cancer to treat the subject for thymic cancer.

US Pat. No. 10,245,275

TRITERPENOIDS WITH HIV MATURATION INHIBITORY ACTIVITY

VIIV HEALTHCARE UK (NO. 4...

1. A method for treating a human infected with HIV comprising administering to said human the compound
or a pharmaceutically acceptable salt thereof and an additional agent selected from the group consisting of dolutegravir, GSK1265744, and 3TC.

US Pat. No. 10,245,271

TREATMENT OF IMPAIRED COGNITIVE FLEXIBILITY WITH TRKB RECEPTOR ANTAGONISTS

Florida State University ...

1. A method of treating impaired cognitive flexibility, the method comprising administering to a subject having impaired cognitive flexibility a therapeutically effective amount of a selective tyrosine kinase B (TrkB) receptor antagonist compound, the therapeutically effective amount being sufficient to improve cognitive flexibility in the subject;wherein the selective TrkB receptor antagonist compound does not inhibit tyrosine kinase A (TrkA) or tyrosine kinase C (TrkC) receptors;
wherein the subject is identified as having at least one of attention deficit hyperactivity disorder (ADHD), autism spectrum disorder, and Asperger's syndrome; and
wherein the TrkB receptor antagonist compound is at least one compound selected from (a) ANA-12, (b) an ANA-12 based compound, and (c) a pharmaceutically acceptable salt of compound (a) or (b), wherein ANA-12 comprises the formula

US Pat. No. 10,245,270

SALT OF 3-[(3-{[4-(4-MORPHOLINYLMETHYL)-1H-PYRROL-2-YL]METHYLENE}-2-OXO-2,3-DIHYDRO-1H-INDOL-5-YL)METHYL]-1,3-THIAZOLIDINE-2,4-DIONE, ITS PREPARATION, AND FORMULATIONS CONTAINING IT

LES LABORATOIRES SERVIER,...

1. E isomer of 3-[(3-{[4-(4-morpholinylmethyl)-1H-pyrrol-2-yl]methylene}-2-oxo-2,3-dihydro-1H-indol-5-yl)methyl]-1,3-thiazolidine-2,4-dione methanesulphonate of formula (II):
having an X-ray powder diffractogram which exhibits the Bragg's angles 2 theta (expressed in terms of °+0.2) 7.55; 10.42; 14.84; 15.06; 15.25; 15.80; 16.81; 17.01; 17.95; 19.06; 20.00; 20.29; 21.88; 23.87; 24.31; 24.64; 26.13; 26.59.

US Pat. No. 10,245,267

BIARYL AMIDE COMPOUNDS AS KINASE INHIBITORS

Novartis AG, Basel (CH)

1. A compound, or a pharmaceutically acceptable salt thereof, selected from:

US Pat. No. 10,245,266

3-(4-((4-MORPHOLINOMETHYL-BENZYL)OXY)-1-OXOISOINDOLIN-2-YL)PIPERIDINE-2,6-DIONE FOR THE TREATMENT OF SYSTEMIC LUPUS ERYTHEMATOSUS

Celgene Corporation, Sum...

1. A method for identifying a subject having systemic lupus erythematosus (SLE) who is likely to be responsive to a treatment with a compound of formula Ior a pharmaceutically acceptable salt, stereoisomer, tautomer or racemic mixture thereof, comprising:(a) determining the level of a biomarker in a first sample from the subject, wherein the biomarker is selected from the group consisting of CRBN, IKZF1 (Ikaros), and IKZF3 (Aiolos); and
(b) comparing the level of the biomarker in the first sample to a reference level of the biomarker; wherein the subject is likely to be responsive to the treatment if the level of the biomarker in the first sample is higher than the reference level of the biomarker.

US Pat. No. 10,245,265

SALTS OF 2-FLUORO-N-METHYL-4-[7-(QUINOLIN-6-YL-METHYL)-IMIDAZO[1,2-B][1,2,4]TRIAZIN-2-YL]BENZAMIDE AND PROCESSES RELATED TO PREPARING THE SAME

INCYTE INCORPORATION, Wi...

1. A process of preparing a compound of Formula I:
or salt thereof;
comprising reacting a compound of Formula II:

with a compound of Formula III:

at a temperature from about 120° C. to about 150° C. to form a compound of Formula I, or salt thereof;
wherein X1 is chloro, bromo, or iodo.

US Pat. No. 10,245,264

SUBSTITUTED IMIDAZO[1,2-A]PYRAZINES AS SOLUBLE GUANYLATE CYCLASE ACTIVATORS

12. A pharmaceutical composition comprising the compound of claim 1, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.

US Pat. No. 10,245,263

TETRAHYDROPYRANYL AMINO-PYRROLOPYRIMIDINONE AND METHODS OF USE THEREOF

ArQule, Inc., Burlington...

1. A method of treating chronic lymphoid leukemia, comprising administering to a patient in need thereof a therapeutically effective amount of a compound of Formula (I):or a pharmaceutically acceptable salt, tautomer, prodrug, or solvate thereof.

US Pat. No. 10,245,262

IMMUNOLOGICAL REAGENTS AND USES THEREFOR

The University of Queensl...

1. An MR1-ligand subunit [MR1-L] which binds MAIT cells, wherein said ligand is represented by Formula (I):
or a salt, tautomer, or stereoisomer thereof
wherein:
R1 is selected from the group consisting of:
X—C(O)—R1? (where R1? is H, or optionally substituted C1-C6alkyl, and X is independently a bond or a divalent linker selected from the group consisting of C1-C3 optionally substituted alkylene, —NR2?— optionally substituted C1-C3alkylene-, —O— optionally substituted C1-C3alkylene-, —S— optionally substituted C1-C3alkylene-, —S(O)— optionally substituted C1-C3alkylene-, —N?CR2?—, —CR2??CR2?—, —NR2?—C(O)—, —O—C(O)—, or —S—C(O)— where each R2? and R2? is independently selected from H, halogen, CN, or optionally substituted C1-C6alkyl); —X?—C(O)NR3?R4? (where R3? is H or optionally substituted C1-C6alkyl and R4? is optionally substituted C1-C6alkyl, OH, or CN or R3?R4? together form an optionally substituted heterocyclyl or optionally substituted heteroaryl, and X? is independently a bond or a C1-C3 optionally substituted alkylene); —X?—C(O)OR5? (wherein R5? is H or optionally substituted C1-C6alkyl, and X? is independently a bond or a C1-C3 optionally substituted alkylene); —X??—C(O)NHSO2R6? (wherein R6? is optionally substituted aryl, or optionally substituted C1-C6alkyl, and X?? is independently a bond or a C1-C3 optionally substituted alkylene); and —X??—S(O)2NHR7? (wherein R7? is H, optionally substituted C1-C6alkyl, or optionally substituted aryl, and X?? is independently a bond or a C1-C3 optionally substituted alkylene);
R2 is selected from the group consisting of optionally substituted C1-8alkyl, —NH(optionally substituted C1-6alkyl), —N(optionally substituted C1-6alkyl)(optionally substituted aryl), —N(optionally substituted C1-6alkyl)2, —O(optionally substituted C1-6alkyl), —OC(O)(C1-6alkyl), —S(optionally substituted C1-6alkyl), —SC(O)(C1-6alkyl), and —S(O)(optionally substituted C1-6alkyl); and
Y and Z are oxo.

US Pat. No. 10,245,261

SUBSTITUTED INDOL-5-OL DERIVATIVES AND THEIR THERAPEUTIC APPLICATIONS

NantBio, Inc., Culver Ci...

1. A method of treating cancer in a mammal, wherein the cancer is selected from the group consisting of Chronic Myelogenous Leukemia (CIVIL), Acute Myelogenous Leukemia (AML) and thyroid, endometrial, gastric, breast and pancreatic carcinoma, and wherein the method comprises administering to the mammal a therapeutically effective amount of a composition comprising NTW-3475, wherein NTW-3475 is the compound having the structure:

US Pat. No. 10,245,260

ORGANIC COMPOUNDS

INTRA-CELLULAR THERAPIES,...

1. A method for the treatment of a central nervous system disorder, comprising administering to a patient in need thereof a compound of a Formula I:
wherein:
X is —NH—;
L is O;
Z is —O— or —C(O)—;
in free or salt form;
wherein the disorder is selected from the group consisting of obsessive-compulsive disorder (OCD), obsessive-compulsive personality disorder (OCPD), general anxiety disorder, social anxiety disorder, panic disorder, agoraphobia, compulsive gambling disorder, compulsive eating disorder, body dysmorphic disorder, hypochondriasis, pathological grooming disorder, kleptomania, pyromania, attention deficit-hyperactivity disorder (ADHD), attention deficit disorder (ADD), impulse control disorder, pain disorders, cephalic pain, neuropathic pain, idiopathic pain, chronic pain, fibromyalgia, chronic fatigue, opiate dependency, cocaine dependency, amphetamine dependency, alcohol dependency, and combinations thereof.

US Pat. No. 10,245,259

METHODS OF TREATING RBP4 RELATED DISEASES WITH TRIAZOLOPYRIDINES

Belite Bio, Inc, (KY)

1. A method of treating a metabolic disease or disorder in a subject in need thereof, the method comprising administering to the subject a composition comprising a therapeutically effective amount of a compound of Formula (I), or a pharmaceutically acceptable salt thereofwherein:each R1 is independently halogen, haloalkyl, or alkyl;
R2 is —H, —OH, or halogen;
p is 0, 1, 2, 3, 4, or 5; and
A has the structure:

wherein:
?, ?, ?, and ? are each independently absent or present, and when present each is a bond;
X is N;
Z1 is S, O, or N;
Z2 is S, O, N, or NR3;
R3 is H, C1-C4 alkyl, or oxetane; and
B is a substituted or unsubstituted fused 5-, 6-, or 7-membered ring structure; and
wherein the metabolic disease or disorder is non-alcoholic fatty liver disease (NAFLD) or non-alcoholic steatohepatitis (NASH).

US Pat. No. 10,245,258

TREATMENT OF A HEMATOLOGIC MALIGNANCY WITH 2-(4-CHLOROPHENYL)-N-((2-(2,6-DIOXOPIPERIDIN-3-YL)-1-OXOISOINDOLIN-5-YL)METHYL)-2,2-DIFLUOROACETAMIDE

Celgene Corporation, Sum...

1. A method for treating, managing, or ameliorating a hematological cancer comprising administering to a subject in need thereof 2-(4-chlorophenyl)-N-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)-2,2-difluoroacetamide, which has the following structure:or a stereoisomer or mixture of stereoisomers, isotopologue, pharmaceutically acceptable salt, tautomer, solvate, hydrate, co-crystal, clathrate, or polymorph thereof (Compound 1), wherein Compound 1 is administered to the subject in a dose of about 0.1 mg to about 20 mg, and the subject is further administered one or more of calcium, calcitriol, or vitamin D supplementation.

US Pat. No. 10,245,256

NITROXIDES FOR USE IN TREATING OR PREVENTING DIABETES AND OBESITY

Mitos Pharmaceuticals, In...

1. A method of treatment comprising:identifying a subject having elevated TNFa levels, and
administering to the subject an amount of a nitroxide antioxidant effective to reduce said levels in the subject, wherein the nitroxide antioxidant is selected from the following formulas:

wherein X is selected from O— and OH, and R is selected from COOH, CONH2, CN, and CH2NH2;

wherein X is selected from O— and OH, and R1 is CH3, R2 is C2H5, or R1 and R2 taken together are spirocyclohexyl;

wherein X is selected from O— and OH and R is selected from CONH2; and

wherein X is selected from O— and OH and R is selected from H, OH, and NH2, or wherein the nitroxide antioxidant is selected from the group consisting of 4-Oxo-2,2,6,6-tetramethylpiperidine-1-oxyl, 4-(2-bromoacetamido)-2,2,6,6-tetramethylpiperidine-1-oxyl, 4-(ethoxyfluorophosphonyloxy)-2,2,6,6-tetramethylpiperidine-1-oxyl, 4-hydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl, 4-(2-iodoacetamido)-2,2,6,6-tetramethylpiperidine-1-oxyl, 4-isothiocyanato-2,2,6,6-tetramethylpiperidine-1-oxyl, 4-maleimido-2,2,6,6-tetramethylpiperidine-1-oxyl, 4-(4-nitrobenzoyloxyl)-2,2,6,6-tetramethylpiperidine-1-oxyl, and 4-phosphonooxy-2,2,6,6-tetramethylpiperidine-1-oxyl.

US Pat. No. 10,245,255

COMPOSITIONS AND METHODS FOR THE TREATMENT OF OBESITY AND RELATED DISORDERS

THE REGENTS OF THE UNIVER...

1. A method of treating a human subject having a condition associated with obesity, insulin resistance, or hepatic steatosis by inhibiting TBK1 and/or IKK? consisting essentially of administering an orally effective amount of amlexanox, or a pharmaceutically acceptable salt thereof, to a human subject having a condition associated with obesity, insulin resistance, or hepatic steatosis, wherein the subject does not have an allergy, an aphthous ulcer, or bronchial asthma, and wherein the administering causes a reduction of body fat in the subject.

US Pat. No. 10,245,254

GLUTAMINASE INHIBITORS

Cornell University, Itha...

1. A compound, or a pharmaceutically acceptable salt thereof, of structure:wherein A is a piperidinyl;Y1 and Y2 are each independently N or C with the proper valency;
X1 and X2 are each independently —NH—, —O—, —CH2—O—, provided that when at least one of X1 and X2 is —CH2—O—, then the —CH2— is directly connected to A;
a and b are each independently 0 or 1;
c and d are each independently 0 or 1;
Z1 and Z2 are each independently selected from thiadiazole, pyridazine, or pyridine; and
R1 and R2 are each independently optionally substituted alkyl, optionally substituted aralkyl, optionally substituted cycloalkyl, amino, optionally substituted heteroaralkyl, optionally substituted alkylalkoxy, optionally substituted alkylaryloxy, optionally substituted aryl, optionally substituted heteroaryl, or optionally substituted heterocycloalkyl;
provided that if Y1 is N and Y2 is C, then a=0 and b=1;
provided that if Y1 is C and Y2 is N, then a=1 and b=0;
provided that if c=0 and d=0, then R1 and R2 are both amino;
provided that if c is 1 and d is 1, then both R1 and R2 are not amino;
provided that if c is 0 and d is 1, then R1 is amino and R2 is optionally substituted alkyl, optionally substituted aralkyl, optionally substituted cycloalkyl, optionally substituted heteroaralkyl, optionally substituted alkylalkoxy, optionally substituted alkylaryloxy, optionally substituted aryl, optionally substituted heteroaryl, or optionally substituted heterocycloalkyl; and
provided that if c is 1 and d is 0, then R2 is amino and R1 is optionally substituted alkyl, optionally substituted aralkyl, optionally substituted cycloalkyl, optionally substituted heteroaralkyl, optionally substituted alkylalkoxy, optionally substituted alkylaryloxy, optionally substituted aryl, optionally substituted heteroaryl, or optionally substituted heterocycloalkyl.

US Pat. No. 10,245,252

USE OF ALKYLAMIDOTHIAZOLES IN COSMETIC OR DERMATOLOGICAL PREPARATIONS FOR THE PROPHYLAXIS OR TREATMENT OF SENSITIVE SKIN

BEIERSDORF AG, Hamburg (...

1. A method for the treatment or prophylaxis of sensitive skin, itching, dry skin, as well as of inflammatory states of the human skin, wherein the method comprises applying to skin of a subject in need thereof a cosmetic or dermatological preparation comprising one or more alkylamidothiazoles of the following formula in an amount which is effective for the treatment or prophylaxis of sensitive skin, itching, dry skin, inflammatory states of the human skin:
in which
R1, R2, X and Y are different, partly identical or completely identical and, independently of one another, represent:
R1=—C1-C24-alkyl (linear and branched), —C1-C24-alkenyl (linear and branched), —C1-C8-cycloalkyl, —C1-C8-cycloalkyl-alkylhydroxy, —C1-C24-alkylhydroxy (linear and branched), —C1-C24 alkylamine (linear and branched), —C1-C24-alkylaryl (linear and branched), —C1-C24-alkylaryl-alkyl-hydroxy (linear and branched), —C1-C24-alkylheteroaryl (linear and branched), —C1-C24-alkyl-O—C1-C24-alkyl (linear and branched), —C1-C24 alkyl-morpholino, —C1-C4 alkyl-piperidino, —C1-C24 alkyl-piperazino, or —C1-C24 alkyl-piperazino-N-alkyl;
R2=H, —C1-C24-alkyl (linear and branched), —C1-C24-alkenyl (linear and branched), —C1-C8-cycloalkyl, —C1-C24-hydroxyalkyl (linear and branched), —C1-C24-alkylaryl (linear and branched), or —C1-C24-alkylheteroaryl (linear and branched);
X=-phenyl, optionally mono- or polysubstituted with —OH, —F, —Cl, —Br, —I, —OMe, —NH2, —CN, or cetyl;
Y=H, —C1-C24-alkyl (linear and branched), —C1-C24-alkenyl (linear and branched), —C1-C8-cycloalkyl, —C1-C24-aryl, —C1-C24-heteroaryl, —C1-C24-alkylaryl (linear and branched), —C1-C24-alkylheteroaryl (linear and branched), -phenyl, -2,4-dihydroxyphenyl, -2,3-dihydroxyphenyl, -2,4-dimethoxyphenyl, -2,3-dimethoxyphenyl, —COO-alkyl, —COO— alkenyl, —COO-cycloalkyl, —COO-aryl, or —COO-heteroaryl;
and wherein the one or more alkylamidothiazoles are present as a free base and/or as a cosmetically and dermatologically acceptable salt thereof.

US Pat. No. 10,245,251

SYNERGISTIC PHARMACEUTICAL COMBINATION FOR THE TREATMENT OF SQUAMOUS CELL CARCINOMA OF HEAD AND NECK

PIRAMAL ENTERPRISES LIMIT...

1. A method for the treatment of squamous cell carcinoma of head and neck in a subject comprising administering to said subject a therapeutically effective amount of:a CDK inhibitor of formula I:

wherein Ar is 2-chloro-4-trifluoromethylphenyl; or a pharmaceutically acceptable salt or solvate thereof; and
a therapeutically effective amount of one or more antineoplastic agents selected from sorafenib, and lapatinib.

US Pat. No. 10,245,249

PHARMACEUTICAL COMPOSITIONS COMPRISING NITROXYL DONORS

Cardioxyl Pharmaceuticals...

1. A pharmaceutical composition comprising a N-hydroxysulfonamide type nitroxyl donor and an aqueous buffer, wherein the N-hydroxysulfonamide type nitroxyl donor is a compound of the formula (1)andwherein the composition has a pH of from about 5 to about 6.5.

US Pat. No. 10,245,248

FAP-ACTIVATED THERAPEUTIC AGENTS, AND USES RELATED THERETO

BACH BIOSCIENCES, LLC, C...

1. A prodrug represented by the general formula
or a pharmaceutically acceptable salt thereof, wherein:R1 represents (C1-C10)alkyl, (C1-C10)alkoxy, (C1-C10)alkyl-C(O)—(C1-C10)alkyl, (C3-C8)cycloalkyl, (C3-C8)cycloalkyl(C1-C10)alkyl, aryl, aryl(C1-C10)alkyl, heteroaryl, or heteroaryl(C1-C10)alkyl, wherein any R1 is optionally substituted with one or more substituents independently selected from the group consisting of halo, hydroxy, carboxylate, cyano, amino, nitro, and thio (—SH); or —C(?X)R1 represents an N-terminally blocked alpha amino acid residue and X is O;R2 represents H or a (C1-C6)alkyl;R3 represents a (C1-C6)alkyl;R4 is absent or represents one, two or three substituents, each independently selected from a (C1-C6)alkyl, —OH, —NH2, or halogen;X represents O or S;Cyt?, or Cyt?L-NH, represents a cytotoxic compound or cytostatic compound, less a hydrogen atom; andL represents a 4- to 8-membered ring which is part of the cytotoxic compound or cytostatic compound and is recognized by FAP as a P?1 residue; or L is a self-immolative linker which is metabolized after FAP cleavage to release Cyt?,wherein the prodrug is selectively converted to the cytotoxic compound or cytostatic compound by FAP+ stromal cells.

US Pat. No. 10,245,247

OMEGA-3 FATTY ACID ARTICLES OF MANUFACTURE, AND METHODS AND APPARATUS FOR MAKING SAME

AMBO INNOVATIONS, LLC, O...

1. An article of manufacture comprising a lipid resulting from a source of omega-3 fatty acids co-processed with a hydrophilic flavonoid, a lipophilic anti-oxidant, and melatonin in a concentration effective to inhibit lipid destroying enzymes.

US Pat. No. 10,245,240

TREATMENT OF PROSTATE CARCINOMA

PELLFICURE PHARMACEUTICAL...

1. A method of inhibiting or delaying the growth of prostate cancer, comprising administering to a human having prostate cancer a therapeutically effective amount of a compound of Formula (I) or a pharmaceutically acceptable salt of Formula (I):
wherein:
R1 is methyl;
R2 is hydrogen;
R3 is —OH;
R4 is hydrogen;
R5 is hydrogen;
R6 is hydrogen; and
wherein the compound of Formula (I) is administered to the human in combination with, subsequent to, or concomitantly with, an androgen deprivation therapy that reduces production of dihydrotestosterone (DHT), androsterone, androstenediol, androstenedione, dehydroepiandrosterone (DHEA), or dehydroepiandrosterone sulfate (DHEA-S); and wherein the growth of prostate cancer is inhibited or delayed.

US Pat. No. 10,245,234

METHOD OF TREATING CANCER WITH EDIBLE OIL DERIVED EXCIPIENTS

1. A method of treating breast cancer consisting intravenously administering to a subject in need thereof a therapeutically effective amount of substantially ethanol free nanoparticle composition wherein nanoparticle composition consists nanoparticles having hydrodynamic diameter of 10 to 200 nm consisting 1 to 10 percent by weight of a taxane and 90 to 99 percent by weight of a substantially hydroxyl free unsaturated oil saturated at least at one site of unsaturation by a covalently attached hydrogen atom and a covalently attached water soluble polymer of formula—S—(CH2)n—S-X-POLYwherein n is an integer selected from 2 to 12,X is thiol reactive linker containing functionalities selected from a group consisting maleimido, acrylate, methacrylate, isocyanate, isothiocyanate, iodoacetamido, bromoacetamido, sulfovinyl, thioether,
POLY is substantially biocompatible water soluble polymer selected from a group consisting polyethylene glycol, polyethylene oxide, polyethylene glycol methyl ether, homo and heterobifuctional polyethylene glycols, polyethylene glycol-co-polypropylene glycol, polyethylene oxide-block-polypropylene oxide, polyethylene glycol-acrylate, polyethylene glycol-methacrylate, methoxypolyethylene glycol-acrylate, methoxypolyethylene glycol-methacrylate, poly(polyethyleneglycol-metahcrylate)s, poly(methoxypolyethyleneglycol-methacrylate)s, poly(N-2-hydroxypropylmethacrylamide), poly(N-vinylpyrrolidone), poly(N-isopropylacrylamide), poly(acrylic acid), poly(methacrylic acid), poly(2-aminoethyl methacrylate), poly(N,N-dimethylaminoethyl methacrylate), poly(2-methacryloyloxyethylphosphorylcholine) and combinations thereof,
substantially hydroxyl free unsaturated oil is oil selected from a group of edible oils consisting olive oil, corn oil, canola oil, soybean oil, rapeseed oil, linseed oil, trilinolein, triolein, peanut oil, sunflower oil, mustard oil, almond oil, palm oil, sesame oil, safflower oil, cottonseed oil, grape seed oil, rice bran oil, mono, di, triglycerides of unsaturated fatty acids of C7 to C22 chain length, unsaturated fatty acids of C7 to C22 chain length, and mixtures thereof,
and taxane is selected from a group consisting paclitaxel, docetaxel, cabazitaxel.

US Pat. No. 10,245,228

SMALL VOLUME ORAL TRANSMUCOSAL DOSAGE FORMS CONTAINING SUFENTANIL FOR TREATMENT OF PAIN

AcelRx Pharmaceuticals, I...

1. A dosage form for oral transmucosal administration to a subject, comprising: from 5.0 micrograms to 100 micrograms sufentanil, wherein said dosage form is bioadhesive and has a volume of less than 30 microliters or a mass of less than 30 mg, wherein the administration of the dosage form to the subject provides a Tmax with a coefficient of variation less than 40%.

US Pat. No. 10,245,225

OIL-FREE EMOLLIENTS IN SUNSCREEN COMPOSITIONS

Rohm and Haas Company, P...

1. A sunscreen composition comprising:(a) an oil-soluble polyalkylene glycol of Formula II:
wherein R is a linear or branched C8-C12 alkyl, n has an average value of from 5 to 20, and m has an average value of from 4 to 16, wherein the polyalkylene glycol has a number average molecular weight of from 500 to 5,000, and wherein the weight ratio of CH2CH(CH2CH3)O units to CH2CH(CH3)O units ranges from 4:1 to 1:4;(b) a dermatologically acceptable carrier, wherein the dermatologically acceptable carrier is selected from the group consisting of oil-in-water emulsions or water-in-oil emulsions; and
(c) a sunscreen active,wherein the polyalkylene glycol is present in an amount of from 2 to 10 weight %, based on the total weight of the composition.

US Pat. No. 10,245,223

USE FOR DYEING KERATIN FIBRES OF A COMPOUND OF AZOMETHINE TYPE BEARING A PYRAZOLOPYRIDINE UNIT

1. A compound chosen from dyes of azomethine type bearing a pyrazolopyridine unit of formula (I), leuco forms of formula (II) thereof, optical isomers and geometrical isomers thereof, tautomers thereof, addition salts thereof with an acid or a base, and solvates or hydrates thereof:wherein in formulae (I) and (II), independently:Z1 represents an oxygen atom or a group —NR6—; and when Z1 represents —NR6—, then R1 and R6 may form, together with the nitrogen atom to which they are attached, an optionally substituted, 5- to 8-membered, saturated, unsaturated or aromatic heterocycle;
R1 and R6 each independently represent:
a hydrogen atom;
a C1-C10 alkyl radical optionally interrupted with one or more non-adjacent heteroatoms, and/or optionally substituted, with one or more groups chosen from i) hydroxyl, ii) optionally substituted 5- to 8-membered, saturated, unsaturated or aromatic (hetero)cycle, iii) —N(R?)R?, iv) —N+R?R?R?? with R?, R? and R?? each independently representing a C1-C6 alkyl group; or
an optionally substituted, saturated, unsaturated or aromatic 5- to 8-membered (hetero)cycle;
R2, R3, R4 and R5 each independently represent:
a hydrogen atom;
an optionally substituted C1-C4 alkyl radical; or
a group chosen from —NH2, —N(H)R10, —N(R11)—R12, —OH and —OR9, with R9 and R10 representing an optionally substituted, linear or branched C1-C6 alkyl, R11 and R12, which may be identical or different, representing an optionally substituted, linear or branched C1-C6 alkyl, it being optional for R11 and R12 to form, together with the nitrogen atom to which they are attached, a saturated, unsaturated or aromatic 5- to 8-membered heterocycle optionally containing one or more other heteroatoms or groups chosen from oxygen and nitrogen, the heterocycle being optionally substituted;
R2, R3, R4 and R5 may form, in pairs, with adjacent radicals, an optionally substituted, saturated or unsaturated or aromatic (hetero)cycle;
R?2 and R?3, which may be identical or different, represent:
a hydrogen atom;
a C1-C6 alkyl radical, optionally substituted with one or more hydroxyl radicals;
a C1-C6 alkyl carboxylate radical; or
a carboxyl radical;
R? represents:
a hydrogen atom;
a C1-C6 alkyl radical;
R?6 represents:
a hydrogen atom;
a halogen atom;
a linear or branched C1-C10 alkyl radical, optionally interrupted with one or more non-adjacent oxygen atoms and/or one or more non-adjacent divalent groups —N(R?9)— and optionally substituted with one or more radicals, which may be identical or different, chosen from —OH and —N(R?7)R?8;
a carboxyl radical;
a C1-C10 alkyl carboxylate;
a radical CONR?7R?8;
a C1-C10 alkoxy radical or a C1-C10 (poly)hydroxyalkoxy radical;
a (poly)(C1-C10 alkoxy)-(C1-C10 alkoxy) radical; or
a radical —O-Ak-N(R?9)R?10 in which Ak is a linear C1-C8 or branched C3-C8 divalent alkylene radical, optionally interrupted with one or more oxygen atoms and/or non-adjacent divalent groups —N(R?7)—;
R?7 and R?8, which may be identical or different, represent:
a hydrogen atom; or
a C1-C8 alkyl radical optionally substituted with one or more hydroxyl radicals;
R?9 and R?10, which may be identical or different, represent i) a linear or branched C1-C6 alkyl radical, ii) a C2-C6 alkenyl radical or iii) a C2-C6 alkynyl radical;
R?9 and R?10 may form, with the nitrogen that bears them, a saturated or unsaturated 5- to 8-membered heterocycle, one of the chain members optionally being an oxygen atom or a nitrogen atom, or a divalent radical —N(R?11)— with R?11 representing a hydrogen atom or a C1-C4 alkyl group, optionally substituted with one or more radicals chosen from —OH, —N(R?7)R?8 and C1-C4 alkyl;
R? represents:
a hydrogen atom; or
a linear or branched C1-C10 alkyl radical, optionally interrupted with an oxygen atom or a divalent group —N(R)— with R representing a hydrogen atom or a C1-C4 alkyl group;
wherein when the compound of formula (I) or (II) is positively charged, then it comprises as many anionic counterions as cationic charges to achieve the electrical neutrality of the molecule.

US Pat. No. 10,245,221

STABILIZED COLOR DEPOSITING SHAMPOO

Celeb LLC, Davie, FL (US...

1. A one-part coloring depositing shampoo composition for human hair comprising:at least one cationic dye;
a nonionic surfactant that is n-methyl alkyl glucamide with carbon chain lengths between 8 and 20;
an aqueous carrier;
a stablizer comprising a combination of Di-t-butyl-4-hydroxyhydrocinnamate and Tris (Tetramethylhydroxypiperidinol) Citrate;
wherein said composition does not contain any anionic surfactant.

US Pat. No. 10,245,220

PROCESS FOR PONGAMOL ENRICHMENT OF KARANJA OIL

BIOSYNTHIS, Saint Cyr So...

1. A cosmetic ingredient, that consists of a solution of at least one extract of karanja oil comprising pongamol (CAS 484-33-3) and karanjin (CAS 521-88-0) in at least one solvent selected from the group of compounds having the following formula (I), or mixtures thereof:
in which:
n is from 0 to 19;
R and R?, which may be identical or different, are alkyls derived from an esterification by a linear or branched alcohol of molecular formula CxH2x+2O, x being from 1 to 30,
R? is either a hydrogen atom or a C1-C3 alkyl group.

US Pat. No. 10,245,219

METHOD FOR THE REMOVAL OF TATTOOS AND SKIN DISCOLOURATION

1. A method for removal of tattoos or skin discoloration, the method comprising:applying from about 0.02 ml to about 0.5 ml of a removal fluid to a pigmentation device to form a wetted pigmentation device, the wetted pigmentation device comprising one or more needles; and
with the wetted pigmentation device, forming a treatment area by contacting the one or more needles to an epidermis while traversing a path defining a circumference a maximum of 3 to 4 times in about 10-15 seconds to remove at least a portion of the epidermis bounded by the circumference,
wherein the removal fluid from the wetted pigmentation device enters the treatment area during the forming the treatment area.

US Pat. No. 10,245,217

ENTERAL SAFETY SYSTEM AND METHODS

1. An enteral safety system, comprising:an oral dispenser having a matching feature and a second matching feature;
an oral dispenser-enteral tubing hub for connecting the oral dispenser to enteral tubing, the oral dispenser-enteral tubing hub having the matching feature and the second matching feature;
the enteral tubing having the matching feature and the second matching feature;
an enteral tubing-feeding tube hub for connecting the enteral tubing to a feeding tube, the enteral tubing-feeding tube hub having the matching feature and the second matching feature; and
the feeding tube having the matching feature and the second matching feature
the matching feature used to facilitate connection of only the elements displaying the matching feature.

US Pat. No. 10,245,216

SYSTEMS, METHODS, AND APPARATUSES FOR MANAGING ADHERENCE TO A REGIMEN

1. A device that removably attaches to a medication container, the device comprising:a housing;
a transducer for notifying a user;
one or more container opening detectors configured to detect when the medication container is opened;
a processor;
a memory configured to store medication information and activity information;
a communication module; and
a connector for attaching the device to the container;
wherein the communication module is configured to send the stored activity information to a user device at a calculated time, wherein the calculated time is determined based on a parameter selected from the group consisting of a user sleep schedule, a user medication schedule, and a time of at least one prior successful transmission of information from the attachable device to the user device.

US Pat. No. 10,245,215

PILL CUTTING AND STORAGE DEVICE

Tyson Triplett, Provo, U...

1. An apparatus, the apparatus comprising:a base;
a fixed member attached to the base, the fixed member comprising a first cutting wedge;
a lever arm pivotably attached to one or more of the base and the fixed member at a pivot point, the lever arm comprising a second cutting wedge, the lever arm positionable between an open position and a closed position, wherein the lever arm rotates to move the second cutting wedge to contact the first cutting wedge where a cutting surface of the first cutting wedge aligns with a cutting surface of the second cutting wedge when the lever arm is in the closed position, wherein the cutting surface of the first cutting wedge and the cutting surface of the second cutting wedge are oriented parallel to an axis of rotation of the pivot point, and wherein the base, the fixed member, and the lever arm form, in a closed position, a first compartment on a first side of the first and second cutting wedges and form a second compartment, separate from the first compartment, on a second side of the first and second cutting wedges, the first side opposite the second side, wherein the base forms a bottom to the first and second compartments; and
a cover positionable over only one side of the first and second compartments formed by the base, the fixed member, and the lever arm, wherein the first and second compartments are enclosed when the cover is positioned over the first and second compartments and the lever arm is in the closed position, wherein the cover is separately pivotable from the lever arm.

US Pat. No. 10,245,214

MEDICATION AND IDENTIFICATION INFORMATION TRANSFER APPARATUS

CRISI Medical Systems, In...

1. A system, comprising:a primary medication container containing medication;
a secondary medication container; and
an information transfer apparatus comprising an information transfer element to enable characterization of the medication, the information transfer apparatus configured to enable the primary medication container to couple to the secondary medication container to allow medication to pass from the primary medication container to the secondary medication container, wherein at least a portion of the information transfer apparatus decouples from the primary medication container when the primary medication container and the secondary medication container are decoupled, and wherein the at least a portion of the information transfer apparatus that decouples from the primary medication container when the primary medication container and the secondary medication container are decoupled is configured to be directly coupled to at least a portion of the information transfer apparatus that remains coupled to the primary medication container when the primary medication container and the secondary medication container are decoupled,
wherein the at least a portion of the information transfer apparatus that decouples from the primary medication container physically affixes to, or remains physically affixed to, the secondary medication container when the primary medication container and the secondary medication container are decoupled, the at least a portion of the information transfer apparatus that decouples from the primary medication container comprising the information transfer element including an information element including information about the medication in the primary medication container,
wherein the primary medication container comprises an information source including information about the medication in the primary medication container, and
wherein the information contained by the information source corresponds to the information contained by the information element,
wherein the information transfer apparatus further comprises an adapter, wherein the information transfer element is directly coupled on a first end to the adapter and configured to directly couple to the secondary medication container on a second end, and wherein the adapter is configured to directly couple to the primary medication container, and
wherein the information transfer element is configured to automatically transfer from the adapter coupled to the primary medication container and physically affix to, or remain physically affixed to, the secondary medication container when the primary medication container and the secondary medication container are decoupled,
wherein the information transfer element further comprises an information disk extending radially from the information transfer element, wherein the information disk is located between and spaced from the first end of the information transfer element and the second end of the information transfer element, and wherein the information element is on a planar and annular portion of an underside of the information disk facing in a direction toward the first end of the information transfer element.

US Pat. No. 10,245,213

DEVICE FOR RECONSTITUTING A PHARMACEUTICAL COMPOSITION

EVEON, (FR)

1. A device for reconstituting a pharmaceutical composition from at least a first component contained in a first container and a second component contained in a second container, comprising:a fluidic unit; and
a power unit releasably coupled to the fluidic unit,wherein the fluidic unit comprises:a first connector comprising a body defining an axial chamber and a rotatable crankpin arranged in the axial chamber, the crankpin comprising a mounting interface configured to mechanically couple to the first container, the crankpin further comprising an axial port configured to fluidically couple to the first container when said first container engages the mounting interface, and a radial port fluidically connected to the axial port of the first connector;
a second connector configured to mechanically and fluidically couple to the second container, the second connector comprising an axial port to fluidically couple to the second container when said second container engages the second connector and a radial port in fluidic link with the axial port of the second connector;
a pump; and
a fluidic circuit comprising channel portions connecting the first connector, the second connector and the pump;
wherein the body of the first connector comprises at least three radial ports connected to the fluidic circuit,
wherein the crankpin comprises at least one channel configured to cooperate with the at least three radial ports of the body of the first connector to selectively connect the axial port of the first connector with at least one channel portion of the fluidic circuit depending on the angular position of the crankpin with respect to the body, and
wherein the power unit comprises:
a power mechanism for actuating the pump; and
transmission means adapted to be connected between an actuator and the crankpin for rotating the first container.

US Pat. No. 10,245,212

VIAL HOLDER DEVICES, METHODS AND SYSTEMS

Orbit Biomedical Limited,...

1. A packaging apparatus for holding a sterile product comprising:(a) a primary packaging holder configured to hold a sterile product therein,
wherein the primary packaging holder includes:
(i) a body including a bottom surface,
(ii) a neck having a smaller cross-sectional area than the body, and
(iii) a top end having a larger cross-sectional area than the neck;
(b) a secondary packaging holder having configured to hold the primary packaging holder, wherein the secondary packaging holder includes:
(i) a base at a first end disposed adjacent the bottom surface of the primary packaging holder, and
(ii) a receiving portion at an opposing second end, wherein the receiving portion includes first and second arc-shaped regions configured to securely retain the neck of the primary packaging holder therebetween, wherein the first and second arc shaped regions are configured to move relative to each other; wherein the top end of the primary packaging holder is exposed outside of the secondary packaging holder based on a height relationship between the secondary packaging holder and the primary packaging holder;
(c) a tertiary packaging holder configured to hold the secondary packaging holder, wherein the tertiary packaging holder includes:
(i) a base at a first end,
(ii) first and second substantially planar opposing walls extending from the base of the tertiary packaging holder, wherein the first and second substantially planar opposing walls have an exterior surface; and
(d) an identifying label attached to the exterior surface of the first and second substantially planar opposing walls.

US Pat. No. 10,245,211

POROUS ACUPUNCTURE NEEDLE AND METHOD FOR MANUFACTURING SAME

DAEGU GYEONGBUK INSTITUTE...

5. A method of preparing a porous acupuncture needle having an interior and a surface, the method comprising forming a porous structure on the needle surface by performing an anodizing process in an electrolyte containing the needle and a carbon electrode,the needle is used as a positive electrode and the carbon electrode is used as a negative electrode, and
the anodizing process is performed by applying a direct current voltage of 20 to 38V for 30 minutes to 2 hours,
wherein the surface and interior both comprise iron (Fe) at 45% to 46%, chromium (Cr) at 17% to 19%, carbon (C) at 30% to 34%, nickel (Ni) at 2% to 3%, and aluminum (Al) at 1.5% to 2%, when measure by an energy dispersive spectrometer (EDS), wherein no layer is formed between the surface and the interior, and wherein the surface forms 5 to 20 holes per 100 ?m2 of the surface area.

US Pat. No. 10,245,210

WHIRLPOOL SPA MOTOR PUMP OF WHIRLPOOL MASSAGE BATHTUB

1. A whirlpool spa motor pump of a whirlpool massage bathtub, comprising:a lower housing having an upper flange and a lower flange;
an impeller for rotating by a motor, which is provided to the lower housing, so as to generate suction force;
an upper housing coupled to an upper portion of the lower housing by a coupling means and having suction holes and discharge holes;
two or more slider rails vertically provided on the outside of the lower housing;
a mounting bolt provided to the upper and lower flanges so as to be positioned at one side of the slider rail;
a slider fitted with the mounting bolt; and
a slider holder inserted into the slider so as to be screw-coupled with the mounting bolt.

US Pat. No. 10,245,209

SYSTEMS AND METHODS FOR GRAVITY-ASSISTED CARDIOPULMONARY RESUSCITATION

1. A method, comprising:performing CPR with at least the head of an individual elevated by bending the individual at the waist to at least 20 degrees relative to horizontal while the individual's legs are generally aligned with a horizontal plane, wherein CPR is performed with an automated device that compresses the chest while the head is elevated; and
interfacing a device for regulating the intrathoracic pressure with the individual:
wherein the automated device includes a band that is positioned around the thorax of the individual;
wherein the band around the thorax tightens with each compression and relaxes with each decompression, and
wherein the band around the thorax tightens when at least the head is elevated.

US Pat. No. 10,245,208

THERAPEUTIC DEVICE

HORSEWARE PRODUCTS LTD., ...

1. A therapeutic device for treating a limb of a human or a non-human animal, the therapeutic device comprising:a wrap having a pocket;
an elongate, flexible panel;
a plurality of recesses formed in the elongate, flexible panel;
a top covering on a top surface of the elongate, flexible panel and a bottom covering on a bottom surface of the elongate, flexible panel;
at least one vibrating source retained in a first recess of the plurality of recesses;
a battery retained in a second recess of the plurality of recesses; and
wires extending between the battery and the at least one vibrating source,
wherein the wrap is configured to be wrapped around a limb, and
wherein the elongate, flexible panel is located within the pocket, the wrap being dimensioned to fit around a part of the limb to be treated.