US Pat. No. 10,166,459

MODULAR RAMP SYSTEM

1. A modular ramp system, comprising:a first ramp component made from a single piece material and having a bottom surface, a top surface above the bottom surface at a height, a first and second inclined surface extending from opposite sides of the top surface to the bottom surface, and a connecting portion formed on the top surface and positioned between the first and second inclined surfaces; and
a first connector releasably joined to the connecting portion of the first ramp component, wherein the first connector has a bottom side formed with a coupling portion including a first and second coupling section connectible to the connecting portion;
wherein the first connector is positionable in a first position in which one of the first and second coupling sections is releasably joined to the connecting portion of the first ramp component and the other of the first and second coupling sections is adapted to releasably couple to a ramp or an external structure, and a second position in which the first and second coupling sections are releasably joined to connecting portion of the first ramp component.

US Pat. No. 10,166,458

SKI POLE BASKET AND SKI POLE WITH SUCH SKI POLE BASKET

KV2 Sagl, Dongio (CH)

1. Ski pole basket (1), comprising at least:a barrel shaped body (2) of the basket, wherein a thread (21) of the body extends along the body (2) at least from one open end face of the body to the opposite end face of the body, and on the opposite end face of the body an end piece (3) of the basket is attached, and
a nut (5) being formed slidably moveable on the ski pole shaft and enterable into a thread joint with the body (2) of the basket,
characterised in that
the basket (1) is made fixedly attachable to the ski pole shaft by means of a sleeve (4), wherein at least on one open end face of the sleeve a circumferential collar (41) of the sleeve is formed, and a guiding ridge (42) of the sleeve extends from the collar (41) of the sleeve to the opposite end face of the sleeve (4),
wherein the thread (21) of the body is formed on the inner surface of the body (2) of the basket, and a guiding recess (24) of the body formed in the body (2) of the basket extends from the thread (21) of the body to the opposite end face of the body, and
wherein the ridge (42) of the sleeve is made to be engageable with the recess (24) of the body when the sleeve (4) is moved into the body (2) of the basket and fixedly attachable in the recess (24) of the body by means of resting the nut (5) against the collar (41) of the sleeve.

US Pat. No. 10,166,457

TAPERED TRAMPOLINE ENCLOSURE

1. A trampoline comprising:a frame, wherein the frame includes legs for supporting the frame above a ground surface;
a bed suspended on the frame by springs, wherein the springs attach between the frame and the bed;
an enclosure including enclosure poles, wherein the enclosure poles are upwardly extending from the frame so that the enclosure poles terminate at pole tips, wherein the enclosure further includes an enclosure net suspended from the pole tips; and
a plurality of tapered pole connector panels, wherein each one of the plurality of tapered pole connector panels connect to a respective one of the pole tips, wherein the plurality of tapered pole connector panels are connected to the enclosure net to support the enclosure net and hang the enclosure net from the pole tips, wherein the plurality of tapered pole connector panels are formed from sheet material, wherein the enclosure net is suspended from an enclosure net strapping, wherein the enclosure net strapping is connected to the plurality of tapered pole connector panels that pull a strapping line inside of the enclosure net strapping and the enclosure net toward the pole tips, wherein the enclosure net forms a strapping line angle, wherein the strapping line angle is pulled toward the pole tips.

US Pat. No. 10,166,456

FRONT TOSS MACHINE

1. A method of using a ball tossing machine with a ball comprising the steps of:pivoting a first lever arm about a shoulder joint having a shoulder joint axis of rotation;
pivoting a second lever arm about an elbow joint having an elbow joint axis of rotation, wherein the second lever arm is coupled with the first lever arm by the elbow joint, and wherein the elbow joint axis of rotation is substantially parallel to the shoulder joint axis of rotation;
opening a hand to receive the ball, the hand comprising a finger and a thumb; and
closing the hand around the ball by pivoting the finger and the thumb to clasp the ball.

US Pat. No. 10,166,455

ADJUSTABLE PUTTING GREEN SYSTEM AND METHOD THEREOF

DERON, LLC, Providence, ...

1. A system for a person to practice putting, the system comprising:a framework;
a plurality of actuators coupled to the framework in an array, each actuator including guide structure, a motor and a shaft, the shaft vertically extending between the motor and an upper support, the upper support coupled to an end of the shaft such that the upper support maintains a fixed position relative to linear movement of the end of the shaft, the motor configured to linearly move the shaft and the upper support relative to the framework, the upper support having an upward facing surface, the guide structure configured to guide vertical and linear movement of both the motor and the shaft to move the upper support to various predetermined heights;
an artificial green having multiple layers and a putting surface with a cup defined in the putting surface, the artificial green positioned over the actuators, the upward facing surface of the upper support directly contacting an underside of the multiple layers of the artificial green below the putting surface;
a control system coupled to the actuators, the control system including multiple controllers configured to control actuation of the actuators; and
a computing device coupled to the control system and configured to communicate with the control system, the computing device coupled to a display and including user input controls.

US Pat. No. 10,166,454

SWING ANALYSIS DEVICE, SWING ANALYSIS SYSTEM, SWING ANALYSIS METHOD, AND STORAGE MEDIUM

SEIKO EPSON CORPORATION, ...

1. A swing analysis device comprising:an angle calculator that calculates an upper limit angle and a lower limit angle during a predetermined period of swing of a sporting apparatus based on a plurality of angles, formed by the sporting apparatus and predetermined plane, in a plurality of locations during the predetermined period; and
an index setting unit that sets an upper limit plane based on the upper limit angle and a stroke direction, and sets a lower limit plane based on the lower limit angle and the stroke direction,
wherein the upper limit angle and the lower limit angle are the maximum angle and the minimum angle, respectively, of a swing zone determined based on the plurality of angles and a standard deviation of the plurality of angles.

US Pat. No. 10,166,453

SPORTS BALL REBOUNDER NET

Rukket, LLC, Wilmington,...

1. A sports ball rebounder net, comprising:a frame having first and second side posts;
a net suspended within the frame;
a back support adapted to maintain the frame in one or more angles from horizontal over a ground or support surface, said back support having a first arm and a second arm;
a first bracket depending from the first side post, said first bracket defining a pivot point and defining two or more holes therethrough spaced apart from the pivot point;
a second bracket depending from the second side post, said second bracket defining a pivot point and defining two or more holes therethrough spaced apart from the pivot point;
a first plunger associated with the first arm, said plunger retractably deploying a first pin to engage with one of the two or more holes of the first bracket;
a second plunger associated with the second arm, said plunger retractably deploying a second pin to engage with one of the two or more holes of the second bracket; and
a cord directly or indirectly joined at one end to the first plunger and at an opposite end to the second plunger, said cord adapted to be pulled in order to retract the first pin and the second pin out of the two or more holes of the first and second brackets.

US Pat. No. 10,166,452

BAT SWING TRAINING DEVICE

1. A bat swing training device comprising:a bat having a first end and a second end,
a handle portion positioned at said first end of the bat and having a length from about 160 mm to about 350 mm, wherein said handle portion includes a knob;
a barrel portion positioned at said second end of the bat and having a diameter from about 60 mm to about 90 mm, and a length from about 300 mm to about 675 mm, wherein the barrel portion widens from the shaft portion for a distance and then retains a larger diameter for a distance before terminating in the second end;
a shaft portion having a length from about 50 mm to about 150 mm, wherein the shaft portion is positioned between the handle portion and the barrel portion;
wherein said shaft portion includes a first bend of about 90 degrees and a second bend of about 90 degrees, and wherein said first and said second bends form a plane with said handle portion and said barrel portion; and
wherein said barrel portion and handle portion include a longitudinal axis, and wherein said longitudinal axis of said barrel portion is parallel to said longitudinal axis of said handle portion and said handle portion and said barrel portion do not have the same longitudinal axis.

US Pat. No. 10,166,451

RING TOSS GAME

1. A game, comprising:a target box, comprising:
a game board, comprising:
a first game surface positioned in a vertical orientation;
a second game surface positioned in a horizontal orientation to said first game surface when opened;
wherein said first game surface comprises a lid section and a target marking area surrounding said ring hook;
wherein said second game surface comprises a base section having a box section comprising a side wall extending along a perimeter of said base section and forming a barrier around said second game surface;
wherein said box section is pivotally connected to said lid section;
wherein said base section defines said second game surface;
a ring hook connected to said game board and extending from said first game surface, and said ring hook comprises a shank portion connected to said lid section and extending perpendicular to said first game surface, and an arcuate portion extending from said shank portion; wherein said arcuate portion has a sweep of one-hundred and eighty degrees, said ring post is connected to said base section at said center of said second game surface; and said ring post comprises a shaft portion connected said base section and extending perpendicular to said second game surface, and a head portion extending from said shaft portion, wherein said head portion has a cross-sectional dimension larger than a cross-sectional dimension of said shaft portion;
a ring post connected to said game board and extending from said second game surface; and
a ring;
wherein, when said ring is tossed at said game board, said ring hangs on said ring hook, encircles said ring post, or lands on said second game surface; and
wherein said lid section pivots relative to said box section between an open position, in which said lid section is perpendicular to said base section exposing said first game surface and said second game surface, and a closed position, in which said lid section is parallel with said base section enclosing said box section and securing said first game surface and said second game surface within said game.

US Pat. No. 10,166,450

DEVICE FOR ALLOWING SMALL CUPS TO TEMPORARILY SIT INSIDE LARGER BEER PONG CUPS

1. A device adapted for contacting with an uppermost rim of a smaller diameter cup and enabling the uppermost rim of the smaller diameter cup to sit parallel to and on a same horizontal plane as an uppermost rim of a larger diameter cup when both the smaller diameter cup and the larger diameter cup are used for a beer pong drinking game, said smaller diameter cup designed to hold a different beverage than the larger diameter cup, said device comprising:a continuous elastic band for: (i) clipping onto the uppermost rim of the smaller diameter cup and (ii) enabling the uppermost rim of the smaller diameter cup to rest substantially parallel to and on a same horizontal plane as the uppermost rim of the larger diameter cup when the smaller diameter cup is positioned inside the larger diameter cup for use during the beer pong drinking game in which the smaller diameter cup holds a different beverage than the larger diameter cup, said continuous elastic band having three or more spaced downward protrusions for at least temporarily clipping onto the uppermost rim of the smaller diameter cup when the smaller diameter cup and the larger diameter cup are used together in the beer pong drinking game.

US Pat. No. 10,166,449

COMBINED GOLF CLUB HEAD COVER AND STAND

PutterUp, LLC, Louisvill...

1. A combined golf club cover and stand, comprising:a substantially rigid base with a bottom platform; and
a cover portion which, in combination with the substantially rigid base, defines an internal cavity with an open end for receiving a head of a golf club;
wherein the substantially rigid base further includes a first side wall and an opposing second side wall, wherein the second side wall includes a bottom ledge that extends toward the first side wall;
wherein the cover portion spans from the first side wall to the second side wall; and
wherein, in use, when the head of the golf club is received in the internal cavity, the head of the golf club is held against the substantially rigid base, with a toe end of the head of the golf club in contact with an interior surface defined by the first side wall and a heel end of the head the golf club sitting on the bottom ledge of the second side wall, such that, when the bottom platform of the combined golf club cover and stand is on a substantially flat underlying ground surface, the heel end of the head is oriented at an angle relative to an underlying ground surface, and the golf club will stand upright.

US Pat. No. 10,166,448

GOLF CLUB COVER HAVING A PULL MEMBER

SRI SPORTS LIMITED, Kobe...

1. A golf club equipment grouping comprising:a golf club comprising:
a shaft;
a club head attached to the shaft, the club head including a toe portion, a heel portion, a face portion, a rear portion, a sole portion, a crown portion, and a hosel configured for attachment to the shaft; and
a golf club cover configured to cover at least a portion of the golf club, the golf club cover comprising:
a main body comprising:
a first side panel configured to substantially cover the face portion;
a second side panel configured to substantially cover the rear portion; and
an upper panel configured to substantially cover the sole portion, the upper panel extending between the first side panel and the second side panel and defining an upper panel width between the first side panel and the second side panel that varies along a length of the upper panel thereby defining a tapered region of the upper panel;
a sleeve attached to the main body configured to cover at least a portion of the shaft, at least a portion of the sleeve extending between the first side panel and the second side panel;
a pull member attached to the upper panel, the pull member comprising:
a first attachment point fixing the pull member to the main body; and
a second attachment point fixing the pull member to the main body, the second attachment point opposite the first attachment point;
wherein:
the first attachment point and the second attachment point collectively define a body distance, the body distance defined as the shortest distance between the first attachment point and the second attachment point as measured along the exterior of the main body; and
the body distance is greater than or equal to a width between the first side panel and the second side panel of the tapered region.

US Pat. No. 10,166,447

PROGRESSIVE WEIGHTED AEROBIC PING PONG EXERCISE RACQUET

1. An enhanced table tennis racket comprising:a blade portion with an elongated handle portion and a striking surface;
a surface covering on at least a portion of said striking surface;
a recess formed in said blade portion for receiving and securing a mobile computing device; and
a spacer for varying a volume of said recess to provide a secure fit to said mobile computing device, and
wherein said mobile computing device is a smartphone or tablet.

US Pat. No. 10,166,446

COLLECTION CONTAINER FOR BROKEN GOLF TEES

1. An apparatus for collecting broken golf tees utilizing a golf cart or a similar vehicle, wherein said apparatus comprises:a collection container comprised of a resilient shock resistant material, wherein the collection container has a planar bottom that provides dampened flexibility, wherein the bottom has a plurality of elliptical holes/slots that are sufficient in size and number to drain away rain water keeping the collection container free of standing water, yet small enough to retain any fractional element of the broken golf tees, a set of fastener openings, and contiguous with the planar bottom there is a perimeter wall having sections that are inclined or vertical, wherein the perimeter wall has a height that is at least one fifth as high as the bottom is wide, which is sufficient to retain broken golf tees at any slope angle the golf cart is capable of traversing or at any nominal acceleration or deceleration the golf cart is capable of operating;
a clip-on suspension assembly of attachment brackets that is composed of a resilient elastic material, wherein each attachment bracket has a lower portion shaped similar to a counterclockwise rotated block “U” that is sized to elastically fit over and under a portion of a golf cart's dashboard or another suitably shaped part of a golf cart or a similar vehicle, wherein the lower portion is contiguous with an upper portion shaped similar to a clockwise rotated block “L”, wherein a leg on the “L” is about horizontal and has one or more bracket fastener holes that are aligned with one or more fastener openings on the bottom of the collection container, when using rivets or binding fasteners, and the horizontal leg on the “L” extends rearward elevated over the golf cart's dashboard, wherein an angled section of the “L” functions as a cantilevered spring suspension support for the collection container; and
a fastening means for attaching the top section of the bracket to the container using fastening elements.

US Pat. No. 10,166,445

GOLF PUTTER HEAD ASSEMBLY AND METHOD OF USE

1. A head assembly for a golf putter, comprising:a hosel having a body portion and a finger extension extending from said body portion, said body portion being provided with a concavity defined in major part by a cylindrical concave surface having an axis and a first radius of curvature, said finger extension having a bore for receiving an end of a putter shaft;
a head piece including an elongate body having a putting face on one side and a cylindrical convex surface on an opposite side, said cylindrical convex surface having a second radius of curvature approximately equal to and smaller than said first radius of curvature so that said cylindrical convex surface is engageable with said cylindrical concave surface, said cylindrical convex surface being inserted into said concavity so that said cylindrical convex surface is in contact with said cylindrical concave surface, said head piece being provided at opposite ends of said elongate body with two arms extending in parallel relationship to one another in a direction opposite said putting face, said head piece and said putting face having a width extending from an top side to a bottom side of said head piece, said arms having at free ends thereof opposite said elongate body a height extending between an upper side and a lower side of said arms, said height being at least substantially equal to said width; and
a releasable clamping element operatively engageable with said hosel and said head piece to adjustably fix said hosel and said head piece to one another,
each of said arms being a linear bar provided at a free end, opposite said head piece, with an enlarged end portion.

US Pat. No. 10,166,444

GOLF CLUB WITH REMOVABLE FACE

Acushnet Company, Fairha...

1. A golf club head, comprising:a body including a recess having a top line side wall, a heel side wall, and a sole side wall defining a face support slot that is opened to a toe portion of the body, wherein the body defines a fastener bore that extends into the toe end of the body and includes a threaded portion;
a face member disposed in the face support slot and defining a ball striking surface, wherein a plurality of score lines are recessed into the face member from the ball striking surface;
a toe cap that forms a toe portion of the golf club head, wherein the toe cap defines a through bore that aligns with the threaded bore of the body; and
a threaded fastener that extends through the through bore of the toe cap and is threaded into the threaded portion of the fastener bore of the body,
wherein the fastener extends through the toe cap and into the body to couple the toe cap to the body, and
wherein the toe cap closes the opening of the face support slot, so that the face member is circumscribed by the top line side wall, the heel side wall, the sole side wall and the toe cap.

US Pat. No. 10,166,443

GOLF CLUB HEAD

SUMITOMO RUBBER INDUSTRIE...

1. A golf club head comprising:a face portion;
a crown portion; and
a sole portion,
wherein the sole portion includes:
a toe-side recessed portion arranged on a toe side;
a heel-side recessed portion arranged on a heel side; and
a middle recessed portion arranged between the toe-side recessed portion and the heel-side recessed portion, and
at least one readily deformable portion that extends linearly in a toe-heel direction is formed in the toe-side recessed portion and the heel-side recessed portion.

US Pat. No. 10,166,442

MULTI-LAYER CORE GOLF BALL

Acushnet Company, Fairha...

1. A golf ball comprising a core and a cover, wherein the core comprises:a solid inner core layer formed from an unfoamed composition and having a diameter of 1.10 inches or less, a center Shore C hardness (Hcenter) of 15 or less, and an interface Shore C hardness (Hinner core interface) of from 5 to 15;
one or more optional intermediate core layers; and
an outer core layer having a thickness of 0.20 inches or greater, an inner surface Shore C hardness (Houter core inner surface) of from 40 to 75, and an outer surface Shore C hardness (Houter surface) of 80 or greater;
wherein Houter surface?Hcenter?70;
wherein the inner core layer has a hardness gradient slope (Sinner core) defined as

the outer core layer has a hardness gradient slope (Souter core) defined as
andwherein the interface Shore C hardness of the inner core layer is within 1 Shore C unit of the center Shore C hardness.

US Pat. No. 10,166,441

THREE-COVER-LAYER GOLF BALL HAVING TRANSPARENT OR PLASTICIZED POLYAMIDE INTERMEDIATE LAYER

Acushnet Company, Fairha...

1. A golf ball comprising:a core; and
a two-layer cover disposed about the core, the two-layer cover comprising:
an inner cover layer disposed about the core, the inner layer comprising a polyamide composition; and
a castable thermoset polyurethane outer cover layer having a hardness from about 40 Shore D to about 62 Shore D;
wherein the polyamide composition comprises a transparent polyamide having a light transmission of about 50% or greater, a glass transition temperature of about 75° C. to about 160° C., and a ratio of Charpy notched impact-resistance measured at 23° C. and at ?30° C. of at least about 2.0.

US Pat. No. 10,166,440

GOLF BALL DIMPLE PROFILE

Acushnet Company, Fairha...

1. A golf ball having a generally spherical surface and comprising a plurality of dimples separated by a land area formed on the ball surface, wherein at least a portion of the dimples consist of a top conical sidewall, a bottom portion, and a transition surface that connects the top conical sidewall to the land area, wherein:the bottom portion is defined by a function rotated about a central axis, the function being selected from the group consisting of polynomial, trigonometric, hyperbolic, exponential functions, and the superposition of two or more thereof, excluding linear functions and functions that result in a cone or sphere;
the transition surface is defined by a linear function rotated about a central axis;
the dimples consisting of a top conical sidewall, a bottom portion, and a transition surface have a saucer ratio (Sr), defined as the ratio of the bottom portion diameter (DS) to the dimple diameter (DD), of from about 0.05 to about 0.75; and
the dimples consisting of a top conical sidewall, a bottom portion, and a transition surface have a transition ratio (Tr) of from 0.02 to 0.50, where the transition ratio (Tr) is defined by the equation Tr=1?(DT/DD), where DD is the dimple diameter and DT is the diameter at the point of intersection between the transition surface and the top conical sidewall.

US Pat. No. 10,166,439

BIOMETRIC MONITORING SYSTEM

International Business Ma...

1. A computer-implemented method for monitoring biometric information for a user, the computer-implemented method comprising:receiving, by a computer system, the biometric information corresponding to the user from an activity tracking device worn by the user that generated the biometric information;
identifying, by the computer system, a current activity of the user;
applying, by the computer system, a policy to the biometric information and the current activity of the user;
monitoring, by the computer system, the biometric information corresponding to the user from the activity tracking device worn by the user while the current activity occurs;
generating, by the computer system, an identification of the current activity;
generating, by the computer system, a confidence level percentage value corresponding to the identification of the current activity that is directly related to an amount of information utilized to derive the confidence level percentage value identifying the current activity of the user;
generating, by the computer system, an alert that includes the identification of the current activity, the confidence level percentage value corresponding to the identification of the current activity, an identification of a desired range for the current activity, and an identification of a user-specified recipient corresponding to the alert when the biometric information is out of the desired range for the current activity; and
displaying, by the computer system, the alert that includes the identification of the current activity, the confidence level percentage value corresponding to the identification of the current activity, the identification of the desired range for the current activity, and the identification of the user-specified recipient corresponding to the alert on a display of the activity tracking device worn by the user.

US Pat. No. 10,166,438

APPARATUS, METHOD, AND PROGRAM PRODUCT FOR TRACKING PHYSICAL ACTIVITY

MOTOROLA MOBILITY LLC, C...

1. An apparatus comprising:a processor;
a memory that stores code executable by the processor to:
detect, by use of the apparatus held by a first person, a second person in close proximity to the first person by detecting a wireless device corresponding to the second person, by detecting a voice profile corresponding to the second person, or a combination thereof;
track physical activity of the first person, wherein the physical activity comprises a number of steps the first person takes, a number of stairs the first person steps, a location of the first person over time, an elevation of the first person, an activity of the first person, movements corresponding to the first person, or some combination thereof, and wherein the tracked physical activity comprises information indicating whether the second person is in close proximity to the first person at certain times during the physical activity upon detecting whether the second person is in close proximity to the first person during the physical activity; and
transmit at least a portion of the tracked physical activity of the first person to an electronic identity corresponding to the second person as a result of detecting the second person in close proximity to the first person by detecting the wireless device corresponding to the second person, by detecting the voice profile corresponding to the second person, or the combination thereof to enable attaching at least the portion of the tracked physical activity of the first person to the electronic identity corresponding to the second person and to show that the second person had the same physical activity as the tracked physical activity of the first person, wherein the electronic identity corresponding to the second person comprises an account of the second person used to track physical activity of the second person, and the physical activity of the second person is stored on a storage device.

US Pat. No. 10,166,437

BIOMETRIC MONITORING SYSTEM

International Business Ma...

1. A computer system for monitoring activity information for a user, the computer system comprising:a storage device, wherein the storage device stores program instructions; and
a processor coupled to the storage device via a communications framework, wherein the processor executes the program instructions to:
receive biometric information corresponding to the user from an activity tracking device worn by the user that generated the biometric information;
identify a current activity of the user;
monitor the biometric information corresponding to the user being received from the activity tracking device worn by the user while the current activity occurs;
generate an identification of the current activity;
generate a confidence level percentage value corresponding to the identification of the current activity that is directly related to an amount of information utilized to derive the confidence level percentage value identifying the current activity of the user;
generate an alert that includes the identification of the current activity, the confidence level percentage value corresponding to the identification of the current activity, an identification of a desired range for the current activity, and an identification of a user-specified recipient corresponding to the alert when the biometric information is out of the desired range for the current activity; and
display the alert that includes the identification of the current activity, the confidence level percentage value corresponding to the identification of the current activity, the identification of the desired range for the current activity, and the identification of the user-specified recipient corresponding to the alert on a display of the activity tracking device worn by the user.

US Pat. No. 10,166,436

METHODS AND PROGRAM PRODUCTS FOR BUILDING A WORKOUT

adidas AG, Herzogenaurac...

1. A method for generating a workout with a computing device comprising:the computing device receiving user input indicating features of a desired workout;
the computing device generating the workout, wherein the workout comprises a plurality of intervals, and wherein a first interval comprises an interval intensity and an interval duration
the computing device initiating a graphical display that conveys the number of intervals making up the workout and the interval intensity and the interval duration of the first interval; and
the computing device determining whether a user has performed above the interval intensity for a portion of the interval duration, and adjusting the interval intensity in response to the determination,
wherein the graphical display comprises a plurality of adjacent segments,
wherein each segment represents one of the plurality of intervals,
wherein receiving the user input indicating features of the desired workout comprises receiving at least three numerical inputs from the user: a first numerical input specifying a desired number of intervals, a second numerical input specifying a desired intensity of the first interval, and a third numerical input specifying a desired duration of the first interval,
wherein receiving the user input indicating features of the desired workout further comprises receiving feedback from direct user manipulation of at least one of the segments representing at least one of the plurality of intervals, and
wherein direct user manipulation comprises placing an object over a portion of the segment.

US Pat. No. 10,166,435

BACK EXTENSION EXERCISE APPARATUS

Cybex International, Inc....

1. An exercise apparatus for performing a back extension exercise by a user having a lower back, legs and a trunk that has a longitudinal trunk axis and a trunk weight, the apparatus comprising:a frame,
a seat having a seating surface and a pelvic stabilization pad having a lower back engagement surface,
an input arm assembly interconnected by a first interconnection to a first resistance mechanism,
the input arm assembly including a manually graspable mechanism and being arranged on the apparatus such that the input arm assembly is pivotable beginning from a start motionless position along a path of travel rearwardly toward the pelvic stabilization pad under resistance exerted by the first resistance mechanism,
the seating surface and the pelvic stabilization pad being mounted, adapted and arranged on the frame in a disposition such that the user can simultaneously sit on the seating surface, engage the user's lower back against the lower back engagement surface and manually engage the manually graspable mechanism to pull the input arm assembly against resistance exerted by the first resistance mechanism,
wherein the first resistance mechanism is adapted to increase resistance as a degree of pivoting of the input arm assembly increases along the path of travel away from the start motionless position rearwardly toward the pelvic stabilization pad,
wherein the input arm assembly is interconnected to the first resistance mechanism by a cable, the input arm assembly being interconnected to a cam having a receiving groove that receives the cable, the cam being interconnected to the input arm assembly such that the cam rotates together with pivoting of the input arm assembly, the receiving groove having a profile selected to create a lesser torque force against the user's pulling force when the user starts pulling the arm assembly from the start motionless position and gradually increase torque force against the user's pulling force as the user continues to pull the input arm assembly rearwardly, and wherein the apparatus includes a second interconnection to a second manually selectively adjustable fixed weight resistance mechanism.

US Pat. No. 10,166,434

EXERCISE BIKE

Alexander Caccia, Oxford...

1. An exercise bike comprising:a base;
a frame having a head tube; and
a steering stem mounted in the head tube, and operable to be rotatable about the longitudinal axis of the stem by a user,
wherein a lower part of the frame is pivotally mounted to the base to allow rotation of the frame, relative to the base, about a substantially horizontal axis,
wherein a first resilient mounting is attached to the frame and the base, the first resilient mounting comprising: a first component having an aperture, a second component configured to be rotatably received within the aperture, and a resilient member disposed between the first component and the second component, and a second resilient mounting is attached to the steering stem and the base,
the first and second resilient mountings, together, configured to bias the frame towards a substantially upright position relative to the base, the second resilient mounting further configured to urge the stem substantially into rotational alignment with a predetermined point on the base.

US Pat. No. 10,166,433

EXERCISE MACHINE

Nautilus, Inc., Vancouve...

1. An exercise apparatus for use by a user in performing a striding exercise in which the length of the strides are determined by the length of the user's steps on the apparatus, comprising:a frame;
a first foot link operatively associated with the frame, and a second foot link operatively associated with the frame, each of the first and second foot links having an engagement structure coupled thereto;
a first foot engagement pad fixedly coupled to the first foot link, and a second foot engagement pad fixedly coupled to the second foot link; and
first and second crank arms operatively associated with the first and second foot links, respectively, wherein: the first and second crank arms reciprocally lift and lower rearward end portions of the first and second foot links, respectively, during a striding exercise by a user, and the rearward end portions of the first and second foot links are movable in forward and rearward directions relative to the first and second crank arms, respectively, to permit the first and second foot links to move relative to the first and second crank arms, respectively, with a variable forward-rearward motion determined by the user's striding steps during the striding exercise,
wherein the engagement structure of the first foot link includes a first downward facing surface that is rollingly supported by the first crank arm during the striding exercise; and the engagement structure of the second foot link includes a second downward facing surface that is rollingly supported by the second crank arm during the striding exercise; and
wherein the first downward facing surface is configured to lift the user at the front and rear of each stride to thereby increase the difficulty of the striding exercise, and wherein the second downward facing surface is configured to lift the user at the front and rear of each stride to thereby increase the difficulty of the striding exercise.

US Pat. No. 10,166,432

BED EXERCISE APPARATUS

1. A bed exercise apparatus for a bed with a bed frame, and a headboard positioned by a head of the bed frame, the bed exercise apparatus comprising:a. a lower frame disposed between the head of the bed frame and the headboard; and
b. an upper frame with exercise equipment mounting connections, the upper frame configured to movably connect to the lower frame in such manner that all or a portion of the upper frame may be disposed above a top surface of the lower frame.

US Pat. No. 10,166,431

SELECTORIZED DUMBBELL WITH A WEIGHT SELECTOR HAVING A CONTINUOUS PERIPHERY THAT ENCLOSES AN OPEN INTERIOR

PowerBlock Holdings, Inc....

1. A selectorized dumbbell, which comprises:(a) a plurality of nested weights that provide a stack of left weight plates and a stack of right weight plates;
(b) a handle located between the weight plate stacks, the handle comprising a hand grip extending along an axis and left and right ends extending perpendicularly to the hand grip;
(c) a selector that is insertable into a selected one of a plurality of vertically spaced positions on the handle to couple a selected number of the weights to the handle, wherein the selector has a substantially continuous periphery that substantially encloses an open interior; and
(d) wherein arrays of vertically spaced, inwardly facing slots are provided on the left and right ends of the handle with each slot in the left end of the handle having a corresponding slot at an identical elevation in the right end of the handle so that a plurality of corresponding sets of slots at different vertical elevations are provided by the arrays of slots with the sets of slots defining the plurality of vertically spaced positions on the handle into which the selector may be inserted, and wherein left and right side walls of the selector slide into and are received within one selected set of the inwardly facing slots in the left and right ends of the handle when the selector is installed in the handle.

US Pat. No. 10,166,430

BARBELL COLLAR

VENICE GRAVITY WORX, INC....

1. A barbell collar, comprising:a plate; and
at least two weight bars, a first weight bar and a second weight bar;
wherein said plate comprises a barbell engagement portion, and at least two arm portions;
wherein said two arm portions comprise a heavy arm, and a light arm;
wherein said heavy arm weighs more than said light arm;
wherein said barbell engagement portion is configured to engage with a barbell;
wherein each of said at least two weight bars is attached to each of said at least two arm portions of said plate; and
wherein said at least two weight bars are adapted to engage and hold one or more weights.

US Pat. No. 10,166,429

ADJUSTABLE KETTLEBELL DEVICE

1. An adjustable kettlebell device comprising:a kettlebell base including a housing having a handle provided on said housing, said housing including a chamber formed in said housing and defined by an upper wall and a bottom wall, and including an opening formed in said bottom wall and communicating with said chamber of said housing,
a first weight element including a tubular member extended therefrom for selectively engaging through said opening of said bottom wall of said housing and into said chamber of said housing, said tubular member of said first weight element including a channel formed therein, said tubular member of said first weight element including a rib for forming said channel of said tubular member, and
a latch slidably received in said chamber of said housing and movable to engage with said tubular member for detachably attaching said tubular member of said first weight element to said kettlebell base, said latch including a projection for selectively engaging with said channel of said tubular member of said first weight element, and said latch being selectively engaged with said rib of said tubular member.

US Pat. No. 10,166,428

ADJUSTABLE CLUB

1. An adjustable club comprising:an elongate handle, defined by a proximal end and a distal end, having an opening to a bore at the distal end;
a stud, having an end cap at a distal end of the stud and a rod at a proximal end of the stud configured to engage the bore of the elongate handle;
one or more weights having a centrally located bore extending between a first opening and a second opening, configured to accommodate the stud;
wherein each of the one or more weights has one or more dowels protruding from a proximal side and one or more receiving holes on a distal side, the one or more receiving holes configured to engage the one or more dowels protruding from another of the one or more weights, thereby preventing the one or more weights from rotating relative to one another;
wherein the distal end of the elongate handle has a frustoconical configuration and tapers outward in a distal direction;
wherein the elongate handle further comprises at least one receiving hole, configured to engage the one or more dowels of one of the one or more weights, thereby preventing the one or more weights from rotating relative to the elongate handle;
wherein a proximal end of the rod engages the centrally located bore the one or more weights and the bore of the elongate handle having a friction fit that prevents rotational movement;
wherein the bore of the elongate handle is a threaded bore and the rod of the stud is configured to engage the threaded bore having a frictional fit that prevents longitudinal and rotational movement; and
wherein the proximal end of the elongate handle is a counterweight with a weight equal to a weight of one of the one or more weights such that the center of gravity is down shifted by fifty percent along a longitudinal axis of the elongate handle.

US Pat. No. 10,166,427

WEIGHT SET SELECTOR AND LOCKING MECHANISM

Vintage Gold Holdings Lim...

1. A selectable weight set apparatus comprising:a handle assembly comprising a handle having a first end portion and a second end portion opposite the first end portion;
a first weight set adapted to be supported on the first end portion of the handle and a second weight set adapted to be supported on the second end portion of the handle, each of the first and second weight sets comprising a plurality of weight plates;
an adjustment assembly for selecting a number of weight plates to be retained to the handle assembly, the adjustment assembly comprising at least one selector for movement relative to at least one of the first and second weight sets to engage and select the weight plates in said at least one of the first and second weight sets; and
a locking assembly for fixing the at least one selector relative to said at least one of the first and second weight sets, the locking assembly comprising a first locking element and a plurality of second locking elements, the first locking element being configured for releasable engagement with the at least one selector and one of the plurality of second locking elements on the at least one selector after the at least one selector is moved to engage and select the weight plates in said at least one of the first and second weight sets;
wherein the adjustment assembly further comprises a selector element fixed to the first locking element and operatively connected to the at least one selector for moving the at least one selector to retain a selected number of weight plates, movement of the selector element to advance the at least one selector to a selected weight plate aligning the first locking element with a second locking element associated with the selected weight plate; and
wherein the adjustment assembly further comprises at least one gear assembly for moving the at least one selector to engage and select the weight plates in said at least one of the first and second weight sets, the gear assembly engaging the at least one selector at a first location and the first locking element engaging the at least one selector at a second location different from the first location.

US Pat. No. 10,166,426

EXERCISE APPARATUS

1. A running exercise apparatus, comprising:a belt configured for an engagement around the waist of a user in an as-used position;
a first shoulder strap having a first end in a connection to said belt at a frontal portion of said belt on a front of the body of said user with said belt in said as-used positioning;
a second shoulder strap having a first end in a connection to said belt on said frontal portion of said belt;
a second end of said first shoulder strap and a second end of said second shoulder strap in an operative engagement to maintain said first shoulder strap extending over a first shoulder of said user and said second shoulder strap extending over a second shoulder of said user;
a first leg belt engageable around an upper leg portion of a first leg of said user;
a second leg belt engageable around an upper leg portion of a second leg of said user;
a first elastic band extending between a first end in a first connection to said belt, to a second end in a second connection said first leg belt;
a second elastic band extending between a first end in a first connection to said belt, to a second end in a second connection said first leg belt;
a pair of belt members extending across said belt;
a first of said pair of belt members extending between said connection of said first end of said first shoulder strap to said belt and said first connection of said first elastic band to said belt; and
a second of said pair of belt members extending between said connection of said first end of said second shoulder strap to said belt and said first connection of said second elastic band to said belt.

US Pat. No. 10,166,425

HYBRID RESISTANCE SYSTEM

1. A resistance system for incorporation in exercise equipment, comprising:a first resistance unit having a first resistance property;
a second resistance unit having a second resistance property that is non-inertial and different than the first resistance property, said second resistance unit comprising a user selectable load adjuster;
a user interface that is movable by a user in a first direction and a second direction, wherein the resistance system comprises a uni-directional mode in which the user interface utilizes a load of the first resistance unit in only one of the first and second directions and utilizes a load of the second resistance unit in at least one of the first and second directions;
wherein the user selectable load adjuster is configured to permit adjustment of the load of the second resistance unit in each of the first and second directions.

US Pat. No. 10,166,424

EXERCISE MACHINE HAVING CHANGEABLE DAMPING MECHANISM

1. An exercise machine having a changeable damping mechanism, the exercise machine comprising a first rotating shaft, a damping device and a first changeable damping mechanism which are disposed at a front end of a main body of the exercise machine, characterized by:one side of the first rotating shaft being provided with a first shifting wheel, stepped grooves of different diameters being provided on the first shifting wheel and sized down;
the damping device being disposed on a damping shaft, the damping shaft being disposed close to the first rotating shaft and located at the front end of the main body, the first rotating shaft and the damping shaft being disposed on the main body of the exercise machine, the first rotating shaft and the damping shaft being parallel and spaced apart from each other;
the first changeable damping mechanism including a first speed control mechanism disposed close to the first shifting wheel and a first transmission rope, the first transmission rope having stretch elasticity and being wound on the first shifting wheel and the damping shaft; the first speed control mechanism including a first support, at least one first pull rod, at least one first spring, a first push rod, at least one first pull rope, and a rope fastener; the first support being fixed to the main body, the first pull rod being axially inserted through the first support, a front end of the first pull rod being connected with the first pull rope, a rear end of the first pull rod being sleeved with the first spring, the first push rod being fixed to the rear end of the first pull rod to hold against the first spring; the rope fastener being fixed on the first pull rod to press the first transmission rope wound on the first shifting wheel and the damping shaft, the rope fastener being interlinked with the first push rod; and
a first knob connected with the first pull rope for controlling advance of the first pull rod;
wherein after released, the push rod biased by the first spring being returned, the first transmission rope being shifted on the stepped grooves with different diameters of the first shifting wheel to provide a rotational speed of different gear ratios to drive the damping device on the damping shaft for damping control.

US Pat. No. 10,166,423

SUPPORT APPARATUS FOR PLYOMETRIC EXERCISE

Escape Fitness Limited, ...

1. A support apparatus for use during plyometric exercise comprising a resilient body having a cuboid shape, wherein the cuboid body has a height, width and depth which are all of different lengths to each other such that the apparatus may be arranged in three different orientations in which the uppermost face defines a landing platform of three different heights, and wherein the body comprises a shock absorbing layer formed of a resilient material located at all six sides of the apparatus such that a shock absorbing layer is located at the upper face of the apparatus to define a landing platform whatever the orientation of the apparatus, wherein said support apparatus further comprises a flexible cover surrounding the resilient body and an outer cushioning layer surrounding and encapsulating the shock absorbing layer between the intermediate layer and the flexible cover.

US Pat. No. 10,166,422

TRAMPOLINE SUPPORT FRAME

CROWNTEC (JIANG XI) SPORT...

1. A trampoline support frame comprising a plurality of transversal branch pipes connected to each other so as to form an annular frame provided for a bouncing component to be mounted at inner side thereof, and a plurality of longitudinal branch pipes provided to one of said transversal branch pipes, characterized in that each of said longitudinal branch pipes is respectively provided with a fitting portion, two reinforcing portions integrally extended from said fitting portion to corresponding two side surfaces of said transversal branch pipe and then fixed to said transversal branch pipe by welding, an accommodating space formed between said two reinforcing portions and provided for one of said transversal branch pipes to be located therein, and two bearing surfaces, each of which is formed between two ends of said two reinforcing portions and toward said accommodating space so as to support one of said transversal branch pipes; wherein each of said transversal branch pipes is respectively provided with a curved portion, a first connecting portion provided at one end of said curved portion, and a second connecting portion provided at another end of said curved portion and covering while being fixed to said first connecting portion of another transversal branch pipe, and said first connecting portion is provided with a first opening, and said second connecting portion is provided with a second opening covering said first opening, each of said first connecting portion is respectively provided with two first stepped surfaces located at two opposite outer sides of said first opening while in parallel with each other, and each of said second connecting portions is respectively provided with two second stepped surfaces located at two opposite outer sides of said second opening while in parallel with said two first stepped surfaces, said two reinforcing portions of each of said longitudinal branch pipes being attached to said two second stepped surfaces by welding.

US Pat. No. 10,166,421

COGNITIVE SOLUTION TO ENHANCE FIREFIGHTING CAPABILITIES

International Business Ma...

1. A method for improving firefighting, the method comprising:collecting, by a computer, sensor data from one or more sensors located in proximity to a fire site;
analyzing, by the computer, the sensor data from the one or more sensors located in proximity to the fire site;
receiving, by the computer, additional input data from a source selected from the group consisting of: news articles, weather forecasts, real time weather information, social media posts related to the fire, emergency dispatch data, and historical data related to other fires;
analyzing, by the computer, the additional input data;
retrieving, by the computer, a corpus of firefighting knowledge, wherein the corpus of firefighting knowledge comprises previously generated firefighting recommendations, previously collected sensor data, and previously collected admin input;
performing, by the computer, analytics on the sensor data from the one or more sensors located in proximity to the fire site and the corpus of firefighting knowledge;
identifying, by the computer and based on the sensor data from the one or more sensors located in proximity to the fire site, on the additional input data, and on the corpus of firefighting knowledge, one or more firefighting goals;
generating, by the computer and based on the one or more firefighting goals and the corpus of firefighting knowledge and using supervised machine learning, one or more firefighting recommendations;
scoring, by the computer and using the corpus of firefighting knowledge, the one or more firefighting recommendations based on historical effectiveness of prior firefighting actions;
displaying, by the computer, the one or more firefighting recommendations to an admin;
receiving, by the computer, input from the admin;
updating, by the computer, the one or more firefighting recommendations based upon the input received from the admin;
outputting, by the computer, the one or more firefighting recommendations to one or more devices;
tracking, by the computer, one or more firefighting actions taken by a firefighter;
collecting, by the computer, additional sensor data from one or more sensors located in proximity to the fire site;
determining, by the computer, an effectiveness value for the one or more firefighting actions taken by the firefighter based upon comparison of a change in sensor data collected before and after the one or more firefighting actions with information within the corpus of firefighting knowledge; and
updating, by the computer, the corpus of firefighting knowledge with data selected from the group consisting of sensor data from one or more sensors, analyzed data from the one or more sensors, analytics from the sensor data and the corpus of firefighting knowledge, firefighting recommendations, and scores of the one or more firefighting recommendations.

US Pat. No. 10,166,419

METHOD AND SYSTEM FOR DILUTING MULTIPLE CHEMICAL CONCENTRATES AND DISPERSING RESULTANT SOLUTIONS UTILIZING A SINGLE PORTABLE SOURCE

PERIMETER SOLUTIONS LP, ...

1. A system for diluting concentrated liquids and dispersing resultant solutions comprising:a plurality of concentrated liquid chemical containers;
a plurality of control valves each correspondingly connected to the plurality of concentrated liquid chemical containers and in fluid relationship therewith;
a single high pressure pump connected to each of the plurality of control valves and in fluid relationship therewith, wherein the plurality of control valves are connected between the plurality of concentrated liquid chemical containers and the single high pressure pump such that when the single high pressure pump is energized, the single high pressure pump solely draws the concentrated liquid chemicals from the plurality of liquid chemical containers through the corresponding control valves;
a liquid pressure adjustment valve connected to both the single high pressure pump and a source of diluent or solvent and in fluid relationship;
a hose connected to the liquid pressure adjustment valve and in fluid relationship; and
a nozzle connected to the hose and in fluid relationship for dispersing a diluted solution, wherein the hose is connected between the liquid pressure adjustment valve and the nozzle.

US Pat. No. 10,166,418

FIRE PROTECTION STRIP

HILTI AKTIENGESELLSCHAFT,...

1. A fire-protection tape, comprising:at least two main plies comprising an intumescent material, wherein the plies have a first longitudinal edge on one outer side and a second longitudinal edge on an opposite outer side, in each instance; and
at least one intermediate ply comprising a second intumescent material disposed between adjacent main plies;
wherein the second intumescent material has a lower intumescence temperature than the material of the main plies, and
wherein the intermediate ply is disposed at the first longitudinal edges of the main plies, wherein the second longitudinal edges of the main plies are flexibly connected with one another, such that the main plies are configured to gape apart at the first longitudinal edges after activation of the intermediate ply, and wherein the intermediate ply does not extend to the second longitudinal edges of the main plies.

US Pat. No. 10,166,417

RESPIRATOR HAVING AN INTEGRATED ORONASAL MASK

1. A respirator comprising:an outer mask defining a first volume;
an oronasal mask defining a second volume, the oronasal mask being positioned within the first volume;
a conduit positioned within the first volume, the conduit having a first end and second end distal the first end, the first end of the conduit being in communication with the first volume and allowing air to flow from the first volume into the conduit, the second end of the conduit including a one-way valve that allows air to flow out of the conduit and into the second volume, at least a portion of the conduit being positioned below the oronasal mask;
a primary filter affixed to the outer mask; and
a secondary filter located within the conduit and within the portion of the conduit below the oronasal mask.

US Pat. No. 10,166,416

RESPIRATOR MASK SPEECH ENHANCEMENT APPARATUS AND METHOD

3M Innovative Properties ...

1. A respirator mask comprising:a mask body configured to define a clean air envelope between the mask and the mouth and nose of wearer;
speech enhancement apparatus comprising:
a microphone configured for attachment to the mask body, the microphone further configured to detect acoustic energy within the clean air envelope when attached to the mask body;
a speaker configured to produce acoustic energy outside of the clean air envelope;
a controller operably connected to the speaker and the microphone, wherein the controller is configured to:
receive a speech signal from the microphone, wherein the speech signal is indicative of acoustic energy detected by the microphone within a first frequency range; and
deliver an output signal to the speaker, wherein the output signal is configured to cause the speaker to emit compensating acoustic energy, wherein the compensating acoustic energy is emitted in one or more predetermined attenuated frequency ranges that cover less than all of the first frequency range, and wherein the compensating acoustic energy comprises a predetermined attenuated amplitude profile over each predetermined attenuated frequency range of the one or more predetermined attenuated frequency ranges.

US Pat. No. 10,166,415

BREATHING APPARATUS WITH TANK ALIGNMENT SYSTEM

MSA Technology, LLC, Cra...

1. A system, comprising:a carrier system adapted to be worn by a user and comprising a rigid backplate to support at least one of a plurality of tanks of pressurized breathing gas having different tank diameters, each of the plurality of tanks comprising a tank valve at an end thereof, the tank valve having an outlet,
at least one pressure regulator attached to the carrier system and a connector attached to the carrier system which is in fluid connection with the at least one pressure regulator;
a bracket connector attached to the rigid backplate of the carrier system; and
a plurality of brackets, each of the plurality of brackets having a different configuration, each of the plurality of brackets being attachable to an associated one of the plurality of tanks prior to attachment of an assembly comprising one of the plurality of brackets and the associated one of the plurality of tanks to the carrier system to capture at least a portion of the tank valve thereof and being severally and removably attachable to the bracket connector, wherein, for each one of the plurality of brackets, the assembly comprising the one of the plurality of brackets and the associated one of the plurality of tanks, when attached to the bracket connector, positions the associated one of the plurality of tanks adjacent the rigid backplate and positions the outlet of the tank valve of the associated one of the plurality of tanks of the assembly at a unique predetermined rearward position relative to the carrier system and at a unique predetermined vertical position relative to the carrier system, wherein the unique predetermined rearward position of the tank valve outlet relative to the carrier system and the unique predetermined vertical position of the tank valve outlet relative to the carrier system for each of the plurality of tanks coincides generally with a predetermined arc so that a distance between the tank valve outlet of the associated one of the plurality of tanks and the connector varies by less than 0.5 inches.

US Pat. No. 10,166,414

HANDHELD FORCIBLE ENTRY DEVICE

20. A handheld forcible entry device, comprising:a tubular housing formed extending along a longitudinal axis between a proximal end and a distal end of the tubular housing;
a torque application end provided at an exposed portion of said forcible entry device, said torque application end configured to rotate about a torque application axis, said torque application axis arranged in a transverse direction generally perpendicular to said longitudinal axis of the tubular housing;
a lead screw comprising a threaded body extending between a proximal end and a distal end of the lead screw, wherein said lead screw is housed within and rotationally assembled to said tubular housing, wherein said lead screw is formed about a lead screw axis oriented generally parallel to said longitudinal axis of the tubular housing;
a gear assembly comprising a gear connecting portion coupled to the proximal end of the lead screw providing unison rotation therewith about the lead screw axis, the gear assembly configured to convert a rotation of the torque application end about the torque application axis into a rotation of the gear connecting portion of the gear assembly about the lead screw axis;
a movable platform threadably engaged with said threaded body of the lead screw;
a fixed wedge plate comprising an operating edge, said fixed wedge plate being assembled to said distal end of the tubular housing;
a movable wedge plate comprising an operating edge; and
at least one column, each column of said at least one column having a distal end and a proximal end, said proximal end of said each column assembled to said movable platform and said distal end of said each column assembled to said movable wedge plate; wherein
a torque applied to said torque application end rotates said torque application end, which in turn rotates said gear connecting portion of said gear assembly, which in turn rotates said lead screw in unison therewith, rotation of the lead screw causing a translation of said movable platform in a direction parallel to said lead screw axis, said translation of said movable platform causing a translation of said at least one column, said translation of said at least one column moving said movable wedge plate relatively to said fixed wedge plate; and further wherein
said movable wedge plate is configured to adopt a compressed position relative to said fixed wedge plate in which respective exposed surfaces of said fixed and movable wedge plates are coplanar.

US Pat. No. 10,166,413

CONTROLLED DESCENT SAFETY SYSTEMS AND METHODS

BAILOUT SYSTEMS, LLC, Ci...

1. A system for controlled release of a descent line, the system comprising:a housing;
a shaft at least partially retained within the housing and having a central axis, the shaft being secured to a first end of a descent line, wherein the shaft rotates about the central axis when a force is applied to a second end of the descent line;
a magnet cradle housing coupled to a first end of the shaft such that the magnet cradle housing rotates together with the shaft;
at least one magnet retained by the magnet cradle housing, such that the at least one magnet is coupled with the shaft;
a coil assembly coupled with the housing is magnetic proximity to the at least one magnet, the coil assembly and the at least one magnet cooperating to facilitate generation of electric current when the shaft is rotating;
a ferrous body coupled to a second end of the shaft;
an electromagnet coupled with the housing in magnetic proximity to the ferrous body;
a first terminal electrically coupled with the coil assembly;
a second terminal electrically coupled with the electromagnet and in electrical communication with the first terminal to facilitate transmission of the electric current generated by the coil assembly to the electromagnet such that the electromagnet cooperates with the ferrous body to facilitate reduction of a rotational speed of the shaft.

US Pat. No. 10,166,411

SYSTEMS AND METHODS FOR ACCELERATING HEALING OF IMPLANTED MATERIAL AND/OR NATIVE TISSUE

Guided Therapy Systems, L...

1. A method of enhancing a cosmetic implant, the method comprising:targeting a location of the cosmetic implant in a patient;
determining an enhancement necessary to improve an aesthetic of the cosmetic implant;
delivering ultrasound energy to tissue surrounding the cosmetic implant, the ultrasound energy creating at least one lesion in the tissue surrounding the cosmetic implant;
improving the aesthetic of the cosmetic implant with the ultrasound energy.

US Pat. No. 10,166,410

FOCUSED ULTRASOUND GUIDING SYSTEM AND METHOD THEREOF

CHANG GUNG UNIVERSITY, T...

1. An ultrasound system, which guides a focused ultrasound energy to a target point located in a tissue of a central nervous system, comprising:a focused ultrasound device generating a focus point and delivering said energy to said target point which is a tissue wrapped by a hard tissue, and said target point is located in an interested region of an individual;
a first tracking point, a second tracking point and a computer unit, wherein said first tracking point provides fixed reference coordinates and is arranged at a location whose relative position to said interested region of said individual is invariable, and wherein said second tracking point is arranged on an ultrasonic transducer of said focused ultrasound device, and said computer unit retrieves an image of said interested region of said individual, and said image of said interested region of said individual is a previously obtained image obtained with an MRI (Magnetic Resonance Imaging) technology or a CT (Computed Tomography) technology;
reference points on said interested region with spatial positions, and wherein said computer unit records said reference points on said interested region to determine coordinates of said reference points in said image of said interested region;
a calibration tracker connecting with said computer unit;
a dummy arranged on said ultrasonic transducer, wherein said dummy includes a tip pointing out a spatial position of said focus point, and said tip of said dummy, said second tracking point and said first tracking point are tracked by said calibration tracker and said computer unit to search said spatial position of said, focus point and said computer unit compares said spatial positions of said first tracking point, said second tracking point and said reference points with said coordinates of said first tracking point, said second tracking point and said reference points in said image of said interested region to establish the positional relationship between said first tracking point, said second tracking point and said reference points in said image of said interested region, whereby said spatial position of said focus point corresponds to coordinates of said focus point in said image of said interested region based on known positional relationship between said second tracking point and said focus point; and
a fixture fixing said interested region of said individual.

US Pat. No. 10,166,409

FLUOROSCOPIC DEVICE, MOVING BODY TRACKING DEVICE FOR RADIATION THERAPY, AND X-RAY DETECTOR

SHIMADZU CORPORATION, Ky...

1. An X-ray fluoroscopic device that is used for a radiation therapy apparatus to perform a radiation therapy by irradiating a therapeutic beam to a subject, comprising:an X-ray imaging mechanism having an X-ray tube and an X-ray detector that detects an X-ray that is irradiated from the X-ray tube and then transmits through the subject;
a correction region of said X-ray detector;
wherein a scattered radiation caused by irradiating said therapeutic beam to said subject can be incident therein, but the X-ray that is irradiated from said X-ray tube and transmits through the subject cannot be incident therein; and
a correction element that corrects data acquired from a region other than the correction region of the X-ray detector by applying the data acquired from the correction region.

US Pat. No. 10,166,408

CANCER THERAPY SYSTEM TREATMENT BEAM PROGRESSION AND METHOD OF USE THEREOF

1. A method for treating a tumor with positively charged particles, comprising the steps of:transporting the positively charged particles sequentially from an accelerator, along a beam transport path, through a nozzle system, and along a treatment beam path; and
while scanning the treatment beam path along each of a set of vectors for treating the tumor, on average for the set of vectors, intentionally deviating the treatment beam path from a current vector of the set of vectors off of the current vector by at least one-eighth of a treatment beam diameter at least once for every twenty movements of the treatment beam.

US Pat. No. 10,166,407

SYSTEM AND METHOD FOR COUCH SAG COMPENSATION IN IMAGE GUIDED RADIO THERAPY

SHANGHAI UNITED IMAGING H...

1. A method for using in a two-modality apparatus, wherein the two-modality apparatus comprises a couch with a table top, a first modality unit having a first isocenter, a second modality unit having a second isocenter, the method comprising:acquiring an image of a target portion of the object when the table top is at a second working position of the second modality unit;
determining a second sag of the table top at a second measurement point of the table top according to the image, the second measurement point of the table top relating to the second isocenter of the second modality unit;
retrieving standard data that provide a relationship relating to a sag of the table top positioned between the first modality unit and second modality unit; and
estimating, based on the second sag and the standard data, a first sag of the table top at a first measurement point of the table top when the table top carrying an object is at a first working position of the first modality unit, the first measurement point of the table top relating to the first isocenter of the first modality unit.

US Pat. No. 10,166,406

RADIATION TREATMENT PLANNING AND DELIVERY USING COLLISION FREE REGIONS

Varian Medical Systems In...

1. A method of determining a radiation treatment plan for delivering radiation to a patient using an external-beam radiation treatment system, the method comprising:receiving, by a computer system, one or more class solutions, wherein each class solution includes field geometry limits for one or more treatment axes of the external-beam radiation treatment system and a corresponding collision free region, and wherein the collision free region comprises a three-dimensional space for allowed initial isocenter positions determined based on a delivery machine model and a patient model;
receiving, by the computer system, a three-dimensional image of the patient;
aligning the three-dimensional image of the patient with the collision free regions of the one or more class solutions;
receiving, via a user interface, a desired initial isocenter position;
determining, by the computer system, that the desired initial isocenter position is within at least one collision free region of the one or more class solutions;
identifying, by the computer system, one or more treatment fields within the field geometry limits of a class solution corresponding to the at least one collision free region; and
determining, by the computer system, the radiation treatment plan using the one or more identified treatment fields.

US Pat. No. 10,166,405

IMAGE-GUIDED RADIOTHERAPY FOR INTERNAL TUMOR BOOST

1. An image-guided radiotherapy method for treating a radio-resistant tumor, wherein the method comprises:a. obtaining a three-dimensional visualized tumor image to identify the tumor;
b. identifying a tumor boundary of the tumor;
c. identifying a planning target volume (PTV) region outside of the tumor boundary, wherein the PTV region is between the tumor boundary and a planning target volume boundary;
d. identifying a boost region within the tumor boundary, wherein a predetermined safety region is between the boost region and the tumor boundary, wherein the predetermined safety region has a predetermined minimum distance from a boost region boundary to the tumor boundary, wherein the boost region is more than 20% of a tumor volume within the tumor boundary;
e. identifying a neighboring structure adjacent to the tumor, wherein the neighboring structure is bounded within a neighboring structure boundary;
f. applying a boosted radiation dose in the boost region;
g. simultaneously applying with the boosted radiation dose a predetermined prescribed radiation dose in the PTV region and within the tumor boundary, wherein the predetermined prescribed radiation dose is smaller than the boosted radiation dose; and
h. repeating steps a. through g. for each subsequent treatment;
wherein the boosted radiation dose is at least 110% of the predetermined prescribed radiation dose for the tumor, wherein the predetermined prescribed radiation dose is about 250 centiGray per day and the boosted radiation dose ranges from about 300 to 450 centiGray per day;
wherein the radiation resistant tumor includes melanoma or renal cancer;
wherein the predetermined minimum distance is dependent on one or more of the boosted radiation dose, the prescribed radiation dose, an importance level, and a radiation sensitivity level of the neighboring structure;
wherein the boosted radiation dose outside of the boost region decreases at a boost dose decreasing rate such that the boosted radiation dose at the tumor boundary is equal to the predetermined prescribed radiation dose; and
wherein the boosted radiation dose and the predetermined prescribed radiation dose decrease at an average decreasing rate such that the boosted radiation dose and the predetermined prescribed radiation dose at the neighboring structure boundary are below a radiation dose threshold of the neighboring structure.

US Pat. No. 10,166,404

METHOD FOR IRRADIATION PLANNING

GSI Helmholtzzentrum fur ...

15. Control device for a radiation facility that provides a scanned particle beam, havinga control unit that controls the radiation facility during irradiation in order to approach target points of a target volume located in a body with the scanned particle beam,
wherein an irradiation plan is divided into a plurality of temporally consecutive irradiation sub-plans including a first irradiation sub-plan and a second irradiation sub-plan, wherein the target points of the target volume are divided among the irradiation sub-plans into a plurality of subsets of target points including a first subset of target points of the first irradiation sub-plan and a second subset of target points of the second irradiation sub-plan wherein the second subset of target points is different from the first subset of target points, and wherein the subsets are each distributed over the entire target volume, and
wherein mutually adjacent target points are assigned to different subsets, such that approach of the target points is varied from irradiation sub-plan to irradiation sub-plan.

US Pat. No. 10,166,403

BRACHYTHERAPY SOURCE ASSEMBLY

Nuvletron Operations B.V....

1. A brachytherapy source assembly for delivering high dose-rate (HDR) or pulsed dose-rate (PDR) brachytherapy using a computer-controlled remote afterloading device, the source assembly comprising:a source device, comprising:
a push/pull wire having a proximal end and a distal end;
a capsule located at a distal end region of the push/pull wire, wherein the capsule includes a chamber at least partially defined by a wall and containing a radioactive source, and wherein a proximal end of the capsule has a diameter that is greater than a diameter of the distal end of the push/pull wire;
a weld attaching the capsule to the push/pull wire;
a plug configured to maintain the radioactive source within the chamber; and
a wear-indication coating covering an exterior surface of the capsule wall, wherein the wear-indication coating has a first color and the exterior surface of the capsule wall has a second color that visibly contrasts the first color of the coating upon visual inspection; and
a dummy device, comprising:
a push/pull wire having a proximal end and a distal end;
a capsule located at a distal end region of the push/pull wire;
a weld attaching the capsule to the push/pull wire; and
a wear-indication coating covering an exterior surface of the capsule, wherein the wear-indication coating has a first color and the exterior surface of the capsule has a second color that visibly contrasts the first color of the coating upon visual inspection;
wherein the dummy device does not include a radioactive source.

US Pat. No. 10,166,402

VISIBLE LIGHT PHOTO-DISINFECTION PATCH

Excelitas Technologies Co...

1. A light conveying device configured to convey light received from a radiation source to a wound, comprising:a radiation conduit optically coupled to the radiation source comprising a radiation ingress portion and a radiation egress portion; and
a flexible panel of radiation transmitting material optically coupled to the radiation conduit, and configured to at least partially conform to a surface contour of the wound,
the flexible panel formed of a single flexible film of the radiation transmitting material defining a first surface, a second surface opposite the first surface,
wherein the first surface has a disrupted surface area that causes radiation received from the radiation conduit to be emitted from the first surface toward the wound,
wherein all of the light that is emitted from the light conveying device toward the wound passes through the first surface of the flexible panel at the disrupted surface area,
wherein the radiation conduit comprises a plurality of fibrous appendages contiguously extending from the flexible panel,
wherein the radiation conduit, including the fibrous appendages of the radiation conduit, is integral with the flexible panel such that the radiation conduit and the flexible panel are formed as a single continuous element, and
wherein the radiation conduit and the flexible panel are formed from the same material and by a process consisting of:
providing a thin sheet or film of the material that includes a panel portion and a skiving portion; and
skiving the skiving portion into the plurality of fibrous appendages,
wherein the panel portion forms the flexible panel of the light conveying device.

US Pat. No. 10,166,401

ANTIGEN DELIVERY DEVICE AND METHOD

PCI BIOTECH AS, Oslo (NO...

1. A device for activating light-induced rupture of endocytic vesicles in target cells of a patient so as to effect delivery of an administered antigen to cytosol in the target cells, the device being adapted to be worn by a patient over a region of the patient's skin where an antigen and a photosensitising agent have been or are to be administered, wherein the device comprises:a rear surface that is configured to be worn against the patient's skin;
a retaining part for retaining the device in place over the region of the patient's skin during an activation cycle;
a light source arranged to illuminate the region of the patient's skin from the rear surface of the device;
a control system to control the operation of the light source after initiation of the activation cycle; and
a power supply to power the light source and the control system,
wherein the control system is configured to vary the output of the light source with respect to time in accordance with a pre-configured output sequence, wherein the output sequence includes an initial stage of at least six hours where the output of the light source is set to be zero or generally below that which could deliver a light dose that can activate light-induced rupture of endocytic vesicles to allow time for the antigen and photosensitising agent to reach the target cells, and a later stage where the output of the light source is set to deliver a light dose to activate light-induced rupture of the endocytic vesicles for effecting the delivery of the administered antigen to the cytosol of the target cells, wherein the light dose is at least 0.05 J/cm2 and is delivered over 5 minutes to 15 hours at an intensity of 0.5 mW/cm2 or less.

US Pat. No. 10,166,400

METHOD FOR SEPARATING NANOGENERATOR AND METHOD FOR MANUFACTURING NANOGENERATOR USING THE SAME

Korea Advanced Institute ...

1. A method for separating a nanogenerator, comprising:laminating a buffer layer on a sacrificial substrate;
making a nanogenerator on the buffer layer;
laminating a metal layer on the nanogenerator; and
separating the nanogenerator from the buffer layer,
wherein said separating the nanogenerator from the buffer layer is performed by applying a mechanical or thermal energy to the metal layer, and
by applying the mechanical or thermal energy to the metal layer, a difference between a residual tensile stress generated at the metal layer and a residual compressive stress at the sacrificial substrate is generated.

US Pat. No. 10,166,399

CHARGE BALANCING CIRCUIT, STIMULATOR CIRCUIT AND METHOD FOR CHARGE BALANCING

1. A charge balancing circuit adapted to be connected to an electrode and to a stimulation source, the stimulation source configured to provide a stimulus to the electrode for functional electrical stimulation of biological tissue, the charge balancing circuit comprising:an electrode terminal configured to receive an electrode voltage;
an amplifier coupled to the electrode terminal and configured to amplify and invert the electrode voltage to generate an intermediate voltage; and
a compensation stage implemented as a transistor stage with a first transistor, the compensation stage configured to generate, when the electrode voltage lies outside a specified safety range, an output current depending on the intermediate voltage by controlling a conductance of the first transistor, and to supply the output current to the electrode terminal for driving the electrode voltage towards and/or into the specified safety range, wherein the specified safety range is predetermined by threshold conditions of the transistor stage.

US Pat. No. 10,166,398

METHODS AND APPARATUS FOR MANAGING MULTIPLE CATHODE PACING

Cardiac Pacemakers, Inc.,...

1. An apparatus for electrical coupling to a plurality of implantable electrodes, the apparatus comprising:a stimulus circuit configured to deliver electrical pacing stimulation to the plurality of implantable electrodes;
a switch circuit configured to electrically couple different combinations of the plurality of implantable electrodes to the stimulus circuit; and
a control circuit to configure a stimulation vector that includes a first electrode of the plurality of implantable electrodes as a first vector electrode and multiple other electrodes of the plurality of implantable electrodes electrically coupled together to form a second combined vector electrode, wherein the control circuit includes a capture detection sub-circuit configured to determine individual capture stimulation energy level thresholds between the first vector electrode and each single electrode of the combined vector electrode; and wherein the control circuit is configured to determine a capture stimulation energy level threshold of the stimulation vector using the determined individual capture thresholds.

US Pat. No. 10,166,397

SYSTEMS AND METHODS FOR INTERMITTENT MULTIPOINT PACING

Pacesetter, Inc., Sunnyv...

1. An implantable cardiac device for providing cardiac resynchronization therapy, the implantable cardiac device comprising:a plurality of electrodes; and
a controller configured to cause alternating between multipoint pacing (MPP) and standard biventricular (BiV) pacing being applied to a patient's heart using the plurality of electrodes or one or more subsets thereof;
wherein whenever the MPP is applied to the patient's heart, two left ventricular (LV) pulses are delivered per cardiac cycle; and
wherein whenever the standard BiV pacing is applied to the patient's heart, only one LV pulse is delivered per cardiac cycle.

US Pat. No. 10,166,396

EFFICIENT DELIVERY OF MULTI-SITE PACING

Medtronic, Inc., Minneap...

1. A pacing device comprising a set of electrodes including a first ventricular electrode and a second ventricular electrode, spatially separated from one another and all coupled to an implantable pulse generator, the device comprising:a processor configured for selecting a first cathode and a first anode from the set of electrodes to form a first pacing vector at a first pacing site along a heart chamber and selecting a second cathode and a second anode from the set of electrodes to form a second pacing vector at a second pacing site along the same heart chamber;
the pulse generator configured to deliver first pacing pulses to the first pacing vector and delivering second pacing pulses to the second pacing vector;
the pulse generator for generating a recharging current for recharging a first coupling capacitor over a first recharge time period in response to the first pacing pulses;
the pulse generator for generating a recharging current for recharging a second coupling capacitor over a second recharge time period in response to the second pacing pulses; and
wherein an order of recharging the first and second coupling capacitors is dependent upon ventricular pacing mode, left ventricle to right ventricle delay, (V-V) pace delay, multiple point LV delay, and latest delivered pacing pulses to one of the first and second pacing vectors.

US Pat. No. 10,166,394

DEVICE AND METHOD TO AUTOMATICALLY TUNE THE NERVE STIMULATION PATTERN OF A SENSORY-FEEDBACK CAPABLE PROSTHESIS

HRL Laboratories, LLC, M...

1. A system for automatically tuning the sensory feedback of a prosthetic device, the system comprising:an implantable electrode configured to administer a stimulus to a peripheral nerve of a user wearing a prosthetic device, the stimulus configured to evoke a muscle response in the user;
a muscle activation sensor configured to measure the muscle response; and
one or more processors and a memory, the memory being a non-transitory computer-readable medium having executable instructions encoded thereon, such that upon execution of the instructions, the one or more processors are configured to perform operations of:
applying a current stimulation pattern to the electrode, the current stimulation pattern corresponding to a position of a prosthetic device of the user;
using the muscle activation sensor to detect the measured muscle response to the current stimulation pattern;
determining a predicted muscle activation using the current stimulation pattern and the posture of the prosthetic device using a spinal cord model; and
using the measured muscle response and predicted muscle activations to dynamically determine an adjusted stimulation pattern configured to compensates for a neuroplastic or hardware change.

US Pat. No. 10,166,393

ACTIVE IMPLANTABLE MEDICAL DEVICE FOR HEART FAILURE TREATMENT BY STIMULATION OF THE VAGUS NERVE

SORIN CRM SAS, Clamart (...

1. An active implantable medical device for the treatment of heart failure by stimulation of a vagus nerve (VNS) or one of its branches, comprising:a VNS pulse generator and an electrode adapted to be placed on or close to the vagus nerve of a patient;
an activity sensor capable of delivering successive values of the patient's current activity level; and
a processor configured to:
collect the electrical activity of the heart, the electrical activity used to determine successive values of a current intrinsic heart rate of the patient;
calculate successive values of a reference heart rate based on the respective successive values of the patient's current activity level, wherein calculating the successive values of the reference heart rate comprises filtering the values of the calculated reference heart rate, by application of a time constant;
construct a first histogram from the reference heart rate depending on the respective values of the patient's current activity level delivered by the activity sensor, over a predefined monitoring period;
construct a second histogram, distinct from the first histogram, from the intrinsic heart rate values over the predefined monitoring period; and
derive an index representative of the patient's condition at the end of the predefined monitoring period, by comparing the first and second histograms.

US Pat. No. 10,166,392

APPARATUS AND METHOD FOR OPTIMIZED STIMULATION OF A NEUROLOGICAL TARGET

ECOLE POLYTECHNIQUE FEDER...

1. An implantable signal router, comprising:a plurality of inputs each configured to receive signals from an implantable stimulator;
a plurality of outputs each configured to electrically communicate with a respective microelectrode; and
a routing circuit comprising a plurality of switches, the routing circuit coupled with each of the plurality of inputs and each of the plurality of outputs, the routing circuit configured to:
selectively interconnect, with at least one switch of the plurality of switches, a first of the plurality of inputs with a first two or more outputs of the plurality of outputs;
route a first signal from the first of the plurality of inputs to the first two or more outputs of the plurality of outputs;
selectively interconnect, with a second at least one switch of the plurality of switches, a second of the plurality of inputs with a second two of more outputs of the plurality of outputs; and
route a second signal from the second of the plurality of inputs to the second two or more outputs of the plurality of outputs.

US Pat. No. 10,166,391

RESPONSIVE NEUROSTIMULATION FOR THE TREATMENT OF CHRONIC CARDIAC DYSFUNCTION

Cybertronics, Inc., Hous...

1. A neurostimulation system, comprising:an electrode assembly; and
a neurostimulator coupled to the electrode assembly, the neurostimulator comprising:
a control circuit; and
a memory operably coupled to the control circuit and comprising instructions that, when executed by the control circuit, cause the control circuit to:
deliver stimulation signals to a patient via the electrode assembly;
increase an intensity of the stimulation signals until a tachycardia heart rate response in the patient is detected;
continue to increase the intensity of the stimulation signals until a bradycardia heart rate response in the patient is detected; and
deliver therapeutic stimulation signals to the patient at an intensity producing a transition heart rate response in the patient, wherein the transition heart rate response corresponds to a zone between the tachycardia heart rate response and the bradycardia heart rate response and is a heart rate reduction between a baseline heart rate and a predefined threshold.

US Pat. No. 10,166,390

HELICAL INSERTER

1. A helical inserter for inserting an insert helically into soft tissue including:a. a housing assembly;
b. a hollow helical insert guide held in functional relationship by the housing assembly such that a proximal aperture of the insert guide is concentric with the housing assembly, wherein the insert guide is adapted to be loaded with the insert through the proximal aperture for helical transport therewith into the soft tissue;
c. a helical insert guide drive which drives the helical insert guide in rotation into the soft tissue; and
d. a guide removal device which, when an insert is present within the insert guide, removes the insert guide while leaving the insert in its intended implant location in the soft tissue.

US Pat. No. 10,166,389

SINGLE-WIRE ELECTRODE ARRAY

Cochlear Limited, Macqua...

1. A tissue-stimulating prosthesis system, comprising:a stimulator unit configured to generate, based on one or more processed signals, electrical stimulation signals for delivery to a recipient; and
a single conductive connection;
a single-wire electrode array comprising a plurality of electrode devices all electrically connected to the stimulator unit via only the single conductive connection,
wherein each of a plurality of the electrode devices comprises a configurable current source, and wherein each of the plurality of the electrode devices are individually addressable by the stimulator unit via the single conductive connection for delivery of the electrical stimulation signals to the recipient using commands encoded with a unique code set for each of the electrode devices.

US Pat. No. 10,166,388

METHOD FOR EXTRACTING TEMPORAL FEATURES FROM SPIKE-LIKE SIGNALS

MED-EL Elektromedizinisch...

1. A system for cochlear implant signal processing, the system comprising:a cochlear implant signal processor configured to convert a speech signal input into multi-channel stimulation pulse sequences for a cochlear implant electrode array;
a temporal feature processing module configured to extract temporal feature information based on fine structure information from the stimulation pulse sequences; and
a speech recognition engine configured to evaluate the temporal feature information using automatic speech recognition to produce speech recognition outputs corresponding to the speech signal input.

US Pat. No. 10,166,386

IMPLANTABLE ELECTRODE ASSEMBLY

The Board of Regents of t...

1. An electrode apparatus comprising:a retainer comprising a stem and at least three clasping arms extending from the stem and movable between an open position and a closed position;
a flexible sheath positioned below a lower surface of the retainer and at least partially surrounded by the at least three clasping arms of the retainer, the retainer is configured to hold the flexible sheath in contacting engagement around a target tissue when the retainer is in the closed position; and
an electrode configured for conducting electrical signals to or from the target tissue, the electrode detachably connected and reattachable to the retainer, the retainer is configured to hold the electrode in electrical communication with the target tissue when the retainer is disposed around the target tissue in the closed position.

US Pat. No. 10,166,385

LEAD AND METHODS FOR BRAIN MONITORING AND MODULATION

BOSTON SCIENTIFIC NEUROMO...

1. An electrical stimulation lead, comprising:an elongate body having a circumference, a proximal portion, a distal portion, and a distal tip;
a first multiple contact connecting terminal disposed along the proximal portion of the elongate body and comprising a plurality of first electrical contacts;
a second multiple contact connecting terminal, separated from the first multiple contact connecting terminal, disposed along the proximal portion of the elongate body and comprising a plurality of second electrical contacts;
at least two stimulating regions longitudinally spaced-apart from each other and disposed along the distal portion of the elongate body, each stimulating region comprising at least three independent stimulation electrodes arranged around the circumference of the elongate body and first insulating material disposed between the stimulation electrodes;
a ring electrode longitudinally spaced-apart and proximal to at least two of the at least two stimulating regions, wherein the ring electrode is a single electrode forming an unbroken ring around the electrical stimulation lead;
and
a plurality of conductors extending along the elongate body to electrically couple the first and second electrical contacts of the first and second multiple contact connecting terminals with the stimulation electrodes and the ring electrode, wherein each of the stimulation electrodes and the ring electrode is attached to a different one of the conductors and each of the conductors is attached to a different one of the first and second electrical contacts of the first and second multiple contact connecting terminals.

US Pat. No. 10,166,384

SYSTEMS AND METHODS FOR TREATING SHOULDER PAIN RELATED TO SUBACROMIAL IMPINGEMENT SYNDROME

SPR Therapeutics, Inc., ...

1. A method comprising the steps of:placing an electrode in subepidermal tissue of a human; and
delivering electrical stimulation through the electrode,
wherein, after the delivering step, a level of pain perceived by the human, wherein the pain was caused by or occurring secondarily to subacromial impingement syndrome, is reduced, and
wherein during the delivering step, a level of pain perceived by the human, wherein the pain was caused by or occurring secondarily to subacromial impingement syndrome, is reduced.

US Pat. No. 10,166,383

METALLIZED FILM ELECTRODE FOR NONINVASIVE ELECTROTHERAPY

EMPI, Inc., Vista, CA (U...

1. An electrode for noninvasive electrotherapy, comprising:a metallized film having a base layer and a metal coating disposed on a bottom surface of the base layer, the metallized film having a first metal-coated area configured for application of therapeutic electrical stimulation to a patient's tissue, wherein a circumference of the first metal-coated area is approximately coextensive with a perimeter of the base layer, wherein the metal coating consists of particles of metal deposited by physical vapor deposition, and wherein the base layer further comprises a tail having a third metal-coated area and a second metal-coated area configured as a unitary extension of the first metal-coated area, wherein the second metal-coated area is situated between the third metal-coated area and the first metal-coated area and is configured to provide a fuse-like functionality;
a gel layer disposed beneath the first metal-coated area, wherein the gel layer extends around a side of the metallized film to cover perimeter side surfaces of the metal coating; and
a connector configured to provide electrical communication to the first metal-coated area, wherein the connector comprises a metal anchor and a lead wire, wherein the metal anchor is disposed beneath the first metal-coated area and wherein the lead wire is configured to provide electrical communication to the metal anchor, the lead wire comprising a metal core and an insulating layer, wherein a first end of the metal core is disposed between the metal anchor and a bottom surface of the first metal-coated area, and wherein the metal anchor is a same type of metallic material as used for the metal coating, and is configured to drive current input from the lead wire through a path of least resistance to the metal coating instead of the gel layer,
wherein a width of the second metal-coated area changes from the proximal end of the second metal-coated area to the distal end of the second metal-coated area and reaches a minimum pinch point at a connection point, wherein a cross-sectional area of a metal coating at the connection point is smaller or narrower than at other points along a longitudinal extension of the second metal-coated area, such that the smaller cross-sectional area at the connection point is configured to concentrate a current density at the connection point.

US Pat. No. 10,166,382

DEVICE FOR BREAKING CANNULAS OF HEMATIC SACS OR SIMILAR, AND CORRESPONDING METHOD

DELCON SRL, Milan (IT)

1. Device for breaking cannulas of sacs comprising a breaking head, and replaceable means for positioning and breaking a cannula which can be driven by the breaking head, wherein said replaceable means are associated to a plurality of mobile breaking pegs, wherein said breaking head is configured to make an alternate backward and forward movement, along an arched or curvilinear segment, or along a linear segment, of said mobile breaking pegs, and wherein the replaceable means comprise at least two fixed contrast pegs, wherein the replaceable means includes a plurality of replaceable members, wherein at least the fixed contrast pegs and/or the mobile breaking pegs associated to at least one of said replaceable members are configured in a different way with respect to at least one other of said replaceable members,wherein each of the replaceable means includes a rotary carousel on which the mobile breaking pegs are disposed,
wherein the mobile breaking pegs are positionable and replaceable with respect to the rotary carousel and/or are positionable and replaceable with respect to the combination formed by the rotary carousel and the mobile breaking pegs,
wherein the rotary carousel has a lower part having a rapid connection portion configured to be inserted in a fork end of a connection element of a motor for kinematically connecting the motor to the replaceable means.

US Pat. No. 10,166,381

ANTISEPTIC CAP

Excelsior Medical Corpora...

1. An antiseptic cap for use with a male luer medical connector, comprising:a base;
an annular wall extending from the base, the annular wall comprising:
a sintered porous plastic material that is substantially rigid, compressible, and absorbent,
an outer surface, and
an inner surface,
wherein the annular wall defines a chamber having an open end and is configured to receive and be compressed by the male luer medical connector; and
an antiseptic material retained within the sintered porous plastic material of the annular wall and configured to be released onto the outer surface of the annular wall and the inner surface of the annular wall when compressed by the male luer medical connector.

US Pat. No. 10,166,380

IMPLANTABLE VENOUS DEVICE

1. An implantable venous device comprising:a catheter including a catheter end and a passage;
a locking nut including an annular convex end and another end opposite to the annular convex end, with a channel extending from the other end to the annular convex end for receipt of the catheter, and with the annular convex end adjacent to the catheter;
an injection seat including a base, a peripheral wall on the base, a space defined by the base and the peripheral wall, and a mounting member projecting out of one side of the peripheral wall, wherein the mounting member and the peripheral wall are formed integrally, and wherein a convex portion is formed at a joining portion of the mounting member and the space;
a connecting tube projecting out of the mounting member and formed integrally therewith, with the connecting tube including a bulged central portion and an annular curved outward end, wherein the locking nut is secured onto the bulged central portion, with the catheter end and the other end abutting with the mounting member and the annular convex end spaced from the mounting member;
a base member including a groove;
a housing including a top opening, a clamping portion on an inner surface of the housing, and a passageway through a bottom edge for receipt of the base member, wherein the injection seat is fastened in the housing, and wherein the locking nut is disposed in the groove of the base member and the passageway; and
an implant member disposed in the top opening and including a peripheral flange urged downward by the clamping portion, with the implant member including a bottom disposed above and parallel to the base of the injection seat.

US Pat. No. 10,166,379

SYSTEMS AND METHODS FOR OPENING OF A TISSUE BARRIER

THE TRUSTEES OF COLUMBIA ...

1. A method for opening a tissue to a target value using microbubbles, comprising:targeting a region of the tissue to open;
determining at least one acoustic parameter corresponding to the target value, the at least one acoustic parameter is selected to control one or more acoustic cavitation events to open the tissue to the target value to thereby allow passage of molecules and/or agents; and
applying an ultrasound beam at the at least one acoustic parameter to the targeted region such that the tissue is opened with the microbubbles to the target value.

US Pat. No. 10,166,378

PERMEANT DELIVERY SYSTEM AND METHODS FOR USE THEREOF

NITTO DENKO CORPORATION, ...

1. A patch for delivering a permeant through a biological membrane of a subject comprising:a) a matrix;
b) at least one hydrophilic permeant disposed within the matrix, wherein at least a portion of the hydrophilic permeant can dissolve in biological moisture received from at least one formed pathway through the biological membrane of the subject;
c) at least one permeability enhancer disposed within the matrix, and
d) at least one solubility control agent disposed within the matrix for controlling the dissolution of the hydrophilic permeant in the biological moisture received by the matrix to control delivery of the hydrophilic permeant into the subject via the at least one formed pathway, wherein the at least one solubility control agent comprises at least one selected from the group consisting of:
an agent that selectively controls the pH of the biological moisture relative to the isoelectric point of the hydrophilic permeant, an agent that selectively controls the ionic strength of the biological moisture, and a salting-out agent.

US Pat. No. 10,166,377

SPINAL TREATMENT METHOD AND SPINAL TREATMENT CATHETER

TERUMO KABUSHIKI KAISHA, ...

1. A spinal treatment method comprising:inserting a balloon catheter along an axis of a spine into a treatment site between nerves extending from the spine, while the nerves are being bifurcated, and a lesion area that compresses the nerves at the treatment site;
positioning a balloon, on which an anti-inflammatory agent is disposed, of the balloon catheter at the treatment site by following the axis of the spine, wherein an axial length of the balloon is disposed in a space between the lesion area and the nerves being compressed;
dilating the balloon in the space between the lesion area and the nerves being compressed, the balloon contacting the lesion area and the nerves being compressed along the axial length of the balloon; and
applying, at least via the balloon contacting the lesion area and the nerves being compressed, the anti-inflammatory agent to the treatment site.

US Pat. No. 10,166,376

RESTRICTED EXPANSION DISSECTOR

Covidien LP, Mansfield, ...

1. A surgical apparatus configured and dimensioned to create an internal surgical worksite, the surgical apparatus comprising: an expandable dissection element having a first resiliency and being expandable to an expanded configuration; and a restrictor formed of a single piece of material having a second resiliency less than the first resiliency, the restrictor being fixedly secured to the dissection element, the restrictor including a pair of first arms and a pair of second arms, the pair of first arms being secured together with a hinge element, wherein the hinge element is a living hinge, and the pair of second arms being secured together, the restrictor being configured to restrict expansion of the dissection element in at least one direction such that the dissection element defines a generally planar configuration in the expanded configuration.

US Pat. No. 10,166,375

BODY FLUID DRAINAGE SYSTEM

University of Washington,...

1. A body fluid drainage system, comprising:a catheter having a proximal portion and a distal portion opposite the proximal portion, wherein the proximal portion is configured to be in fluid communication with a site of excess body fluid within the patient;
a valve device configured to change resistance to flow through the catheter;
a pressure sensor assembly including a first pressure sensor upstream of the valve device configured to measure pressure within a catheter portion upstream of the valve device and a second pressure sensor downstream of the valve device configured to measure pressure within a catheter portion downstream of the valve device, wherein the pressure sensor assembly is configured to be spaced apart from the inlet of the catheter and the ventricles of the patient's brain, and wherein pressure measurements taken from the pressure sensor assembly are used to derive pressure at a position spaced apart from the first and second pressure sensors; and
a controller operatively coupled to the valve device and the pressure sensor assembly, wherein the controller is configured to derive pressure via the pressure sensor assembly, and wherein the controller is configured to change the resistance to flow through the valve device in response to the derived pressure.

US Pat. No. 10,166,374

WEDGE DISSECTORS FOR A MEDICAL BALLOON

Cagent Vascular, LLC, Wa...

1. A medical balloon catheter, comprising:an elongate member comprising a lumen, the elongate member defining a longitudinal axis;
an expandable balloon connected to the elongate member at a distal end of the elongate member;
a plurality of strips, each strip of the plurality of strips including a plurality of wedge dissectors spaced apart along a surface of each strip, each strip extending longitudinally along an outer surface of the expandable balloon,
a base layer on the outer surface of the expandable balloon;
a bonding layer on top of the base layer and on an underside of each of the plurality of strips;
a first retention bonding layer surrounding the outer surface of the expandable balloon and the plurality of wedge dissectors;
at least a second retention bonding layer on top of the first retention bonding layer, wherein the first retention bonding layer and the second retention bonding layer comprise the same material; and
a slip layer over the first retention bonding layer and the second retention bonding layer;
wherein the wedge dissectors comprise a strip-facing base surface directly adjacent the surface of each of the strips, an unhoned radially outward facing surface having a length between a proximal edge of the unhoned radially outward facing surface and a distal edge of the unhoned radially outward facing surface and defining a height of each wedge dissector, and lateral surfaces between the strip-facing base surface and the unhoned radially outward facing surface, wherein the unhoned radially outward facing surface has a first width at the proximal edge, a second width smaller than the first width between the proximal edge and the distal edge, and a third width at the distal edge larger than the second width,
wherein the expandable balloon comprises a plurality of pleats extending from the outer surface and spaced apart from the plurality of strips, wherein the expandable balloon comprises a first reduced configuration in which the wedge dissectors of each strip lie between two adjacent pleats such that a longitudinal axis of each wedge dissector of each strip is in a tangential non-perpendicular orientation with respect to the outer surface of the expandable balloon directly below each wedge dissector of each strip, and wherein the expandable balloon comprises a second expanded configuration wherein the longitudinal axis of each wedge dissector of each strip is in a perpendicular orientation with respect to the outer surface of the expandable balloon directly below each wedge dissector of each strip.

US Pat. No. 10,166,373

ELASTIC TIP FOR AN ADJUSTABLE LENGTH ANGIOPLASTY BALLOON SHEATH

Biosensors International ...

1. An angioplasty balloon catheter comprising an axially moveable retractable sheath and a distal tip attached to a distal end of the sheath,where a distal portion of the retractable sheath is positioned concentrically around an inflatable balloon; and
where the distal tip attached to the distal end of the sheath is an elastomeric plastic having a tensile strength of 41 MPa to 50 MPa, a flexural modulus of between 0.04-0.10 GPa (gigapascals) and a thickness of 140 microns to 191 microns,
wherein the distal tip is capable of returning to substantially its original shape after expansion and deflation of the balloon.

US Pat. No. 10,166,372

ANGIOPLASTY BALLOON IMPROVED WITH GRAPHENE

Cook Medical Technologies...

1. An inflatable medical balloon comprising:a balloon wall defining a balloon interior portion and a balloon exterior portion, wherein the balloon wall comprises an inner layer and an outer layer, wherein the outer layer comprises graphene, and wherein the balloon wall excludes a polymer matrix.

US Pat. No. 10,166,371

NON-COMPLIANT MULTILAYERED BALLOON FOR A CATHETER

ABBOTT CARDIOVASCULAR SYS...

1. A method of making a multilayer balloon for a catheter comprising:selecting a first polymer material having a first maximum blow-up-ratio;
selecting a second polymer material having a second maximum blow-up-ratio greater than the first maximum blow-up-ratio;
selecting a third polymer material having a third maximum blow-up-ratio greater than the second maximum blow-up-ratio; and
forming a multilayer balloon having at least a first layer of the first polymer material, a second layer of the second polymeric material, and a third layer of the third polymeric material having a combined wall thickness, wherein the second layer is an inner layer relative to the first layer and the third layer is an inner layer relative to the second layer, and wherein the at least first, second, and third layers define a compliance less than that of a single layer balloon made of the first polymer material with a wall thickness equal to the combined wall thickness.

US Pat. No. 10,166,370

CATHETER INSERTION DEVICE

B. Braun Melsungen AG, M...

1. A catheter insertion device comprising:a catheter hub comprising a body having an interior surface defining a bore with a Luer taper, a shoulder inside the bore and distal of a proximal opening to the bore, and a catheter tube attached at a distal end of the catheter hub;
a valve comprising at least one slit located inside the bore of the catheter hub for limiting fluid flow through the bore and remaining inside the bore in a ready position and a needle guarded position;
a valve actuator slidably disposed in the bore of the catheter hub; said valve actuator comprising a nose section, a bore, a projection extending radially of a lengthwise axis of the valve actuator, and a plunger section comprising plunger components located proximally of the nose section, said plunger section comprising a gap between the plunger components to permit fluid flow through the gap and the bore of the valve actuator, wherein said plunger section comprises an abutting surface at a proximal end for pushing by a male Luer tip when said male Luer tip is located in said bore of said catheter hub;
a needle having a needle shaft defining a needle axis projecting distally of an end of a needle hub and through the catheter tube with a needle tip of the needle shaft extending out a distal end opening of the catheter tube; and
a needle guard comprising a surface for guarding the needle tip from unintended needle sticks when the needle tip is removed from the catheter hub, said surface of the needle guard being located to a side of the needle shaft in the ready position and being located distal of the needle tip in the needle guarded position to guard the needle tip.

US Pat. No. 10,166,369

DEVICES AND METHOD FOR MAXILLARY SINUS LAVAGE

Acclarent, Inc., Irvine,...

1. A method for lavaging a maxillary sinus, said method comprising:(a) positioning a distal portion of a lavage catheter instrument in nasal anatomy of a patient, wherein the lavage catheter instrument comprises:
(i) an elongate shaft with a bend angle of between about 90 degrees and 140 degrees,
(ii) a distal irrigation tube in coaxial arrangement with said elongate shaft, the distal irrigation tube being coaxially surrounded by the elongate shaft, the distal irrigation tube having side irrigation holes and an atraumatic ball tip that blocks a distal end of the distal irrigation tube,
(ii) a handle comprising:
(A) a proximal end,
(B) a distal end, wherein the elongate shaft extends distally from the distal end, and
(C) an actuator, wherein the actuator is positioned between the proximal end of the handle and the distal end of the handle, and
(iv) a proximal portion comprising an irrigation luer and irrigation tubing, wherein the proximal portion extends proximally from the proximal end of the handle;
(b) connecting a fluid source to the irrigation catheter;
(c) with one hand, advancing the distal end of the irrigation tube into the maxillary sinus by sliding the actuator along the handle, wherein sliding the actuator along the handle comprises sliding the actuator from a proximal position to a distal position, wherein the proximal position is distal to the proximal end of the handle, wherein the distal position is proximal to the distal end of the handle; and
(d) delivering fluid to the maxillary sinus from the fluid source though the lavage catheter.

US Pat. No. 10,166,368

AUTONOMOUSLY CONTROLLABLE PULL WIRE INJECTION CATHETER, ROBOTIC SYSTEM COMPRISING SAID CATHETER AND METHOD FOR OPERATING THE SAME

1. Autonomously controllable pull wire injection catheter (1) comprising an outer catheter guide (2, 33) having an outer catheter guide casing (39) and an inner operating catheter (3, 31) having an inner operating catheter casing (16), wherein the inner operating catheter (3, 31) comprises a catheter handle (30), a catheter tip (10), at least one needle (5) that is connected to at least one source of medicinal solution via at least one needle channel (4, 26), at least one contact force sensor (9a-f, 25), at least one electrode (7, 24), at least four actuator driven pull wires (12-15, 20-23) for moving the tip (10) of the inner operating catheter (3, 31), wherein the inner diameter of the outer catheter guide casing (39) is larger than the outer diameter of the inner operating catheter casing (16), characterized in that the inner operating catheter (3, 31) is adapted to be controlled by a microcontroller, wherein the at least one electrode (7, 24) and the at least one contact force sensor (9a-f, 25) are adapted for data exchange with the microcontroller, and wherein the at least four actuator driven pull wires (12-15, 20-23) are attached inside the inner operating catheter (3, 31) perpendicular to each other at a pre-defined distance from the tip (10) in the distal region (6).

US Pat. No. 10,166,367

MEDICAL DEVICE WITH A NESTED LAP JOINT AND FUSED CONDUCTIVE ELEMENT AND METHOD FOR FABRICATING THE SAME

St. Jude Medical, Cariolo...

1. A medical device for diagnosis or treatment of tissue in a body, comprising:a first shaft including
a longitudinal axis,
a first shaft axial end, and
a first shaft inner surface with an inner step extending axially from the first shaft axial end to an inner edge of the first shaft inner surface extending radially; and
a second shaft including
a second shaft axial end disposed within the first shaft, and
an outer surface including a first outer step extending in an axial direction and a second outer step extending in the axial direction;
a first nested lap joint formed between and connecting the second shaft to the first shaft, the first nested lap joint corresponding to the first outer step of the second shaft;
a second nested lap joint formed between and connecting the first and second shafts, the second nested lap joint corresponding to the second outer step of the second shaft and the inner step of the first shaft; and
a conductive element disposed within at least one of the first and second shafts, the conductive element includes a fused portion fused to at least one of the inner surface of the first shaft and an inner surface of the second shaft.

US Pat. No. 10,166,366

COMPACT URINARY CATHETERS AND METHODS FOR MAKING THE SAME

HOLLISTER INCORPORATED, ...

1. A catheter sub-assembly comprising:a gripping member and a catheter tube carried by and attached to said gripping member, said catheter sub-assembly having a central longitudinal axis,
said catheter tube having a proximal end and a distal end and defining a flow path between said distal and proximal ends wherein said catheter tube is angularly adjustable relative to said axis; and
said gripping member including an outer gripping surface and an aperture in said outer gripping surface in liquid flow communication with said flow path of said catheter tube wherein said gripping member is configured for retaining said catheter tube in an angularly adjusted position relative to said axis.

US Pat. No. 10,166,365

CATHETER ASSEMBLY INCLUDING SEALING MEMBER

Covidien LP, Mansfield, ...

1. A catheter assembly, comprising:a catheter defining at least one lumen;
a hub including at least one hub extension dimensioned to be received within the at least one lumen of the catheter; and
a sealing member being of an expandable material which increases in volume upon exposure to moisture, wherein the at least one hub extension defines a first connector surface and the at least one lumen of the catheter is defined by a second connector surface,
wherein when the at least one hub extension is received within the at least one lumen of the catheter, the first connector surface engages the second connector surface to define an interface, wherein the sealing member is positioned adjacent the interface and is configured to expand into the interface between the first connector surface and the second connector surface upon exposure to the moisture such that the expandable material fills in any gaps between the at least one hub extension and the at least one lumen at the interface.

US Pat. No. 10,166,364

SYSTEMS AND METHODS FOR IMPROVING CATHETER HOLE ARRAY EFFICIENCY

Becton, Dickinson and Com...

1. A peripheral catheter, comprising:a tubular body member of a predetermined diameter and having a wall thickness, the tubular body member having a proximal end, a distal end and a lumen extending therebetween, the tubular body member further having a truncated length sufficient to access a peripheral vein of a patient, the distal end comprising a tapered tip;
a first stripe of a stiffening material;
a second stripe of the stiffening material;
a third stripe of the stiffening material, wherein each of the first stripe, the second stripe and the third stripe are generally aligned with a longitudinal axis of the tubular body member and embedded within the wall thickness of the tubular body member; and
a plurality of holes comprising a first hole disposed between the first stripe and the second stripe and at least partially disposed on the tapered tip of the tubular body member, the plurality of holes further comprising a second hole disposed between the second stripe and the third stripe and at least partially disposed on the tapered tip of the tubular body member, the first hole and the second hole being formed through the wall thickness of the tubular body member and in communication with the lumen.

US Pat. No. 10,166,363

CATHETER

ASAHI INTECC CO., LTD., ...

1. A catheter comprising:a tube body including an inner layer, a reinforcing body covering the inner layer, and an outer layer covering the reinforcing body;
a tubular metallic distal end tip provided at a distal end of the tube body;
a slit on the distal end tip; and
an outer coating on an outer peripheral surface of the distal end tip, at least part of the outer coating is disposed within the slit,
wherein:
the distal end tip has a tapered portion so that a diameter of the distal end tip decreases toward a distal end of the distal end tip, and
a depth of the slit gradually reduces towards the distal end of the distal end tip.

US Pat. No. 10,166,362

PULMONARY EMBOLISM APPARATUS

Sanford Health, Sioux Fa...

1. An apparatus comprising:a first catheter having a proximal end and a distal end, wherein a distal portion of the first catheter includes a first plurality of outlets, and wherein the first catheter has an opening arranged between the proximal end of the first catheter and the first plurality of outlets;
a first tubular housing having a proximal end and a distal end, wherein an exterior surface of the first tubular housing is coupled to an exterior surface of the first catheter proximal to the first plurality of outlets;
one or more pressure sensors coupled to the distal end of the first tubular housing;
a second catheter having a proximal end and a distal end, wherein a distal portion of the second catheter includes a second plurality of outlets, and wherein the distal end of the second catheter is configured to be positioned substantially within the first catheter when the second catheter is in a first position, and wherein the distal end of the second catheter is configured to extend through the opening in the first catheter in a second position; and
a catheter diverter coupled to an interior surface of the first catheter and projecting inward from the opening of the first catheter towards the proximal end of the first catheter to partially obstruct a lumen of the first catheter, such that the second catheter is configured to contact the catheter diverter and is thereby directed through the opening of the first catheter as the second catheter moves from the first position to the second position.

US Pat. No. 10,166,361

METHOD AND APPARATUS FOR AMBIENT SOUND THERAPY USER INTERFACE AND CONTROL SYSTEM

1. An ambient therapy recording and playback system comprising:a rectangular array of microphones comprising four independent multi-directional matched microphones and each of said matched microphones are independent of any other microphone and positioned symmetrically about a center point of the rectangular array and each microphone positioned at one of the four corners of the array thereby having an established sound pickup time delay between matched microphones; and
a recording system having four independent recording channels where each channel receives an independent microphone signal from one of the independent matched microphones independent of any other microphone signal for receiving sounds independently captured by each matched microphone, and further having an electronic storage having stored an electronic recording of each channel's captured sounds thereby having an established recording as an audio sound bed,
where the matched microphones are positioned in a 200 ft. by 200 ft. rectangular array,
where the audio sound bed contains a naturally occurring transient audio event, and
where the recording system has a musical composition stored and has a musical overlay function that overlays the naturally occurring transient audio event with a matching musically composed audio event from the musical composition establishing an audio program.

US Pat. No. 10,166,360

SYSTEM AND METHOD FOR CONTROLLING FLOW DURING EXHALATION IN A RESPIRATORY SUPPORT SYSTEM

KONINKLIJKE PHILIPS N.V.,...

1. An exhalation valve system configured to control gas flow during exhalation of a subject. the system comprising:a pressure generator configured to generate a pressurized flow of breathable gas for delivery to an airway of the subject;
a subject interface comprising a conduit configured to communicate the pressurized flow of breathable gas to the airway of the subject, and an exhalation port configured to place an interior of the subject interface in communication with an exterior of the subject interface,
a valve, coupled to the exhalation port of the subject interface configured to selectively control flow through the exhalation port, the valve comprising a pressure chamber having flexible walls, the pressure chamber comprising a hollow area in fluid communication with the pressure generator via a pressurization control line that is separate from the conduit,
wherein gas from the pressure generator conducted to the valve by the pressurization control line causes movement of the flexible walls to change a volume of the pressure chamber but does not escape the pressure chamber through the valve. the exhalation port, or the conduit, the valve operating in a first mode in which the exhalation port is opened to permit gas flow from the airway of the subject during exhalation, and a second mode in which flow through the exhalation port is restricted with respect to the flow in the first mode; and
wherein the valve is coupled to the pressurization control line at a first end of the valve and coupled to the exhalation port at a second opposite end of the valve, the pressurization control line affecting the volume of the pressure chamber;
a flow component configured to adapt the valve to the exhalation port, the flow component being configured to removably couple with the exhalation port and the valve to form a flow path between the exhalation port and the valve;
one or more sensors configured to generate output signals conveying information related to one or more gas parameters of the pressurized flow of breathable gas; and
one or more processors configured to execute computer program modules, the computer program modules comprising:
a disordered breathing event detection module configured to detect the onset of a disordered breathing event, wherein the onset of the disordered breathing event is detected based on the output signals of the sensors; and
a control module configured to control operation of the valve between the first mode and the second mode based on detections by the disordered breathing event detection module, wherein the control module is configured to cause movement of the flexible walls and thereby cause the volume of the pressure chamber to (i) expand such that the valve operates in the second mode or (ii) contract such that the valve operates in the first mode.

US Pat. No. 10,166,359

CONNECTOR FOR RESPIRATORY DUCTS

Intersurgical AG, Vaduz ...

1. A connector for connecting respiratory ducts together such that they are placed in fluid communication, the connector comprising:a first conduit having a female connector end; and
a second conduit having a male connector end adapted to be received within the female connector end of the first conduit such that the male and female connector ends overlap to provide a common conduit having an inner surface formed at least in part by the male connector end,
wherein the male connector end has a retaining formation which is adapted to abut a corresponding engagement formation on an overlapping portion of the female connector end so as to resist separation of the first and second conduits whilst permitting relative rotation thereof when connected,
and wherein the engagement formation comprises an annular recess on an inner surface of the female connector end shaped to accommodate the retaining formation with a close fit, and the inner surface of the overlapping portion of the female connector end comprises a plurality of depressions and raised portions in the regions between the depressions, the plurality of depressions and raised portions extending in a direction substantially parallel with an axis of the first conduit, the depressions leading into the annular recess.

US Pat. No. 10,166,358

MASK ASSEMBLY SUPPORTING ARRANGEMENTS

ResMed Limited, Bella Vi...

1. A headgear assembly for supporting a patient interface for treating a wearer having a breathing disorder with gas pressurized above atmospheric pressure, the headgear assembly comprising:first and second joining portions configured to be arranged on and removably attachable to opposite ends of the patient interface, each of the first and second joining portions having a patient interface attachment portion at a first end configured to attach to the patient interface, and a headgear attachment portion at a second end; and
headgear having a first strap assembly and a second strap assembly, each of the first and second strap assemblies having:
a first strap portion including:
a first end that is removably attachable to the headgear attachment portion of the respective joining portion; and
a second end that is attached to an ear interface assembly; and
a second strap portion including:
a first end that is removably attachable to the headgear attachment portion of the respective joining portion; and
a second end that is attached to the ear interface assembly; and
the ear interface assembly being structured and dimensioned to be secured to the wearer's ear in use.

US Pat. No. 10,166,357

DELIVERY OF RESPIRATORY THERAPY WITH NASAL INTERFACE

RESMED LIMITED, Bella Vi...

1. A respiratory mask for continuous positive airway pressure treatment comprising:a cushion adapted to be positioned against the face of a patient to deliver breathable gas to the patient,
the cushion being constructed from a polyurethane foam and being configured to form a gasket sealing arrangement around an entrance to the airways of the patient, the cushion including only one exit orifice formed therein to expel the breathable gas from the cushion to deliver the breathable gas to the patient's airways, the exit orifice being configured to be positioned externally of the patient's airways and in fluid communication therewith,
the cushion having a main body and two wings integral with the main body and extending respectively from opposite lateral sides of the main body,
wherein the cushion comprises a single continuous sealing surface extending across the main body, at least a portion of the sealing surface being arranged to, in use, seal with the underside of the patient's nose, the sealing surface having a saddle shape with curvature in two directions including a first direction and a second direction, the first direction being transverse to the second direction,
wherein the curvature in the first direction forms a concave shape, and the curvature in the second direction forms a convex shape structured to accommodate the naso-labial angle of a patient's nose.

US Pat. No. 10,166,356

REVERSIBLE FRAME FOR A PATIENT INTERFACE ASSEMBLY

KONINKLIJKE PHILIPS N.V.,...

1. A method of using a patient interface assembly including a patient interface device and a support assembly, the patient interface device includes a cushion assembly having a support assembly coupling, the support assembly including at least one strap and a reversible frame assembly, the reversible frame assembly including a frame assembly body having a first side and a second side, the frame assembly body including at least a first substantially flat, elongated member and a second substantially flat elongated member, a cushion assembly coupling, and a reversing device, each of the first body member and the second body member coupled at a proximal end to the cushion assembly coupling, the frame assembly body structured to be coupled to the cushion assembly at the cushion assembly coupling with the cushion assembly substantially disposed on one of the first or second sides of the frame assembly body, the frame assembly body structured to be disposed in one of two concave configurations, a first concave configuration, wherein the body first side is concave about at least a portion of the cushion assembly, and a second concave configuration, wherein the body second side is concave about at least a portion of the cushion assembly, and the reversing device structured to allow the frame assembly body to move between the first configuration and second configuration, the method comprising the steps of:coupling the cushion assembly to the frame assembly body while the frame assembly body is in the first configuration;
decoupling the cushion assembly from the frame assembly body;
placing the frame assembly body in the second configuration; and
coupling the cushion assembly to the frame assembly body while the frame assembly body is in the second configuration.

US Pat. No. 10,166,355

NASAL MASK SYSTEM

ResMed Limited, Bella Vi...

1. A nasal mask for delivery of a supply of air to an entrance of a patient's airways, the nasal mask comprising:a superior sealing portion and an inferior sealing portion,
wherein the superior sealing portion and the inferior sealing portion provide a sealing region including a flexible membrane adapted to engage a patient's face and form a seal around both nares of a patient's nose,
wherein the superior sealing portion is constructed and arranged to be substantially located on and to form a seal with a portion of the cartilaginous framework of a patient's nose,
wherein the superior sealing portion comprises the flexible membrane without an undercushion or backup band to provide a first sealing mechanism,
wherein the inferior sealing portion is constructed and arranged to be located in part on a portion of an upper lip of a patient and to direct a sealing force to a portion of a maxilla bone of the patient,
wherein the inferior sealing portion comprises the flexible membrane and an undercushion or backup band to provide a second sealing mechanism that is different than the first sealing mechanism, and
wherein the first and second sealing mechanisms are configured and arranged around a perimeter of the sealing region such that a contact area of the sealing region engaged with the patient's face in use varies around the perimeter of the sealing region to form the seal around both nares of the patient's nose.

US Pat. No. 10,166,354

MASK BEAD FOR PATIENT INTERFACE

Loewenstein Medical Techn...

1. A mask bead for a patient interface, wherein the mask bead has a maximum bead width (B2) and comprises a contact area, a nose bridge area having a width (B1), a ratio (B1) to (B2) being one to three or greater, side areas, a base area, and a bearing area on a patient, the bearing area extending from the side areas and the base area and the nose bridge area to a central opening and being designed as a sealing lip which frames the central opening that serves at least for introduction of a nose of the patient, and wherein (i) a height (H1) in the nose bridge area is greater than a height (H2) of a side area and/or (ii) a ratio of a length (L) of the mask bead to the maximum bead width (B2) is approximately 1 to 1.

US Pat. No. 10,166,353

TOOL AND METHOD FOR INSERTING AN ENDOTRACHEAL TUBE

1. A tool for inserting an endotracheal tube, the endotracheal tube comprising a tubular sheath defining therein a longitudinally extending lumen, the tool comprising:a longitudinal insertion member; and
a guide member configured to facilitate relative longitudinal motion between the insertion member and the endotracheal tube when the insertion member is received within its lumen and comprising a guide wheel having a circumferentially formed engagement arrangement configured to engage with the exterior of the endotracheal tube, when the insertion member is received within its lumen, to move it longitudinally relative to said insertion member.

US Pat. No. 10,166,352

SYSTEMS AND METHODS FOR COMPENSATING LONG TERM SENSITIVITY DRIFT OF ELECTROCHEMICAL GAS SENSORS EXPOSED TO NITRIC OXIDE

Mallinckrodt Hospital Pro...

1. A method for compensating nitric oxide sensor drift affiliated with therapeutic gas delivery, comprising:delivering, via a flow control valve affiliated with a therapeutic gas delivery system, a predetermined dosage of therapeutic gas comprising nitric oxide to a breathing circuit for delivery to a patient;
detecting, via a system controller affiliated with the therapeutic gas delivery system, if an alarm is active or has been active within a predetermined timeframe at a time a nitric oxide sensor calibration is to be executed according to an identified sensor calibration schedule stored in a system controller memory, wherein the nitric oxide sensor calibration is postponed if the active alarm is detected or has been detected within the predetermined timeframe, and the nitric oxide sensor calibration is executed when the active alarm is not detected or has not been detected within the predetermined timeframe, wherein the nitric oxide sensor calibration schedule is modified based upon a change in the predetermined dosage of nitric oxide being delivered to the patient, and wherein the change in the predetermined dosage is an increase in the predetermined dosage, the nitric oxide sensor calibration occurs with a greater frequency;
continuously monitoring, via the nitric oxide sensor affiliated with the therapeutic gas delivery system, a signal indicative of a concentration of nitric oxide in the breathing circuit; and
determining a compensated response to the signal indicative of the nitric oxide concentration in the breathing circuit after the nitric oxide sensor calibration occurs.

US Pat. No. 10,166,351

ENHANCED SYSTEMS, PROCESSES AND APPARATUS FOR FACILITATING INTRANASAL TREATMENT OF A PATIENT AND PRODUCTS THEREBY

Dolor Technologies, LLC, ...

1. An apparatus facilitating intranasal treatment of a patient's sphenopalatine/pterygopalatine recess, the apparatus comprising:a sheath hub comprising a tapered distal end portion, the sheath hub having an exterior surface opposing an interior surface, wherein the exterior surface defines a diameter of the sheath hub, and wherein the interior surface defines a catheter hub receiving space;
a catheter hub positioned longitudinally adjacent to the sheath hub and partially received within the catheter hub receiving space of the sheath hub, the catheter hub comprising a manipulation portion, an insertion portion and a coupling portion collectively forming a unitary body of the catheter hub, wherein:
(i) the manipulation portion has an increased diameter with respect to both the coupling portion and the insertion portion, the manipulation portion is located between the coupling portion and the insertion portion, the manipulation portion is located externally with respect to the sheath hub, the increased diameter of the manipulation portion is the same as the diameter of the sheath hub, and the manipulation portion defines a stopping surface of the catheter hub for contacting an adjoining end of the adjacent sheath hub to arrest further insertion of the catheter hub within the catheter hub receiving space;
(ii) the insertion portion comprises a lumen, the insertion portion extends from the stopping surface defined by the manipulation portion, and the insertion portion is slideably received within the catheter hub receiving space; and
(iii) the coupling portion comprises a treatment receiving port, the treatment receiving port in fluid communication with the lumen of the insertion portion;
a sheath coupled to and extending from the tapered distal end portion of the sheath hub, and a catheter coupled to and extending from the lumen of the insertion portion of the catheter hub, wherein:
(i) an insertion end of the catheter has an intrinsic curvature specifically adapted to access the sphenopalatine/pterygopalatine recess between the patient's middle sinus turbinate and superior sinus turbinate for delivering a medication at a posterior of the sphenopalatine/pterygopalatine recess;
(ii) the sheath straightens the intrinsic curvature of the catheter when the catheter hub is positioned in an extended position;
(iii) the catheter is traversed within the sheath when the insertion portion of the catheter hub is advanced into the catheter hub receiving space of the sheath hub from the extended position;
(iv) the sheath is structurally rigid enough to maintain the intrinsic curvature of the catheter in a straightened form until the insertion end of the catheter exits from a distal end portion of the sheath; and
(v) an outer diameter of the distal end portion of the sheath is tapered and rotationally symmetric around a longitudinal axis of the sheath such that the distal end portion of the sheath slopes to a vertex, the vertex aligning with a beginning of a curve of a tip of the insertion end of the catheter to form a continuous transition between the vertex and the beginning of the curve when the catheter hub is positioned in the extended position; and
an arresting element comprising a flange with a sloped surface extending perpendicularly from a distal end of the insertion portion of the catheter hub, and an engagement element comprising a stopping element with a sloped surface extending perpendicularly from the interior surface defining the catheter hub receiving space, wherein the sloped surface of the stopping element is engaged by the sloped surface of the flange to facilitate insertion of the catheter hub into the catheter hub receiving space, wherein the arresting element continuously engages the engagement element when the catheter hub is received in the catheter hub receiving space and repositioned along a longitudinal axis of the sheath hub, and wherein engagement between the arresting element and the engagement element prevents rotation of the sheath hub with respect to the catheter hub.

US Pat. No. 10,166,350

ACTIVE DRY POWDER INHALER

Inspiro Medical Ltd., Ne...

19. A method of preparing an inhaler capsule containing dry powder medicament with a capsule outlet for the medicament, the method comprising:introducing a needle comprising a gas lumen having at least one gas outlet into an interior of the capsule;
puncturing a wall of the inhaler capsule by forcing the wall against the needle from a capsule interior to define the capsule outlet;
withdrawing the capsule relative to the needle to de-obstruct the capsule outlet, positioning the at least one gas outlet within the capsule interior; and
directing gas into the at least one gas outlet while it remains in the interior and the capsule outlet is de-obstructed, thereby releasing the dry powder medicament from the capsule.

US Pat. No. 10,166,349

FLOW REGULATING INHALER DEVICE

Syqe Medical Ltd., Tel-A...

1. A method of flushing drug residues from a conduit of an inhaler device, the device comprising at least a first conduit for conducting a carrier airflow which delivers at least one drug substance to a user, the method comprising:allowing air to be drawn into said first conduit during inhalation;
during a first time period within said inhalation, heating a drug dose to release said drug substance into said carrier airflow for delivering to said user, while regulating a rate of said carrier airflow according to a target profile;
during a second time period within said inhalation, after heating has terminated, allowing increased carrier airflow through said first conduit to flush drug residues from said first conduit:
wherein said drug residues are flushed via said first conduit into a mouth of said user.

US Pat. No. 10,166,348

INSUFFLATION SYSTEM

Aerosurgical Limited, Da...

1. An apparatus for use in procedures involving insufflation, comprising:an aerosol generator for aerosolizing a fluid into an aerosol and positioned within a generator housing including an entrainment portion;
a trocar for delivery of the aerosol, the trocar comprising a trocar housing to which the aerosol generator is mounted, the trocar having an entry port for an insufflation gas and a distal end through which the aerosol is delivered;
an aerosol delivery tube extending from the entrainment portion and into the trocar housing, wherein the insufflation gas is entrained with the aerosol in the entrainment portion of the generator housing; and
a space between a radially external wall of the aerosol delivery tube and a radially internal wall of the trocar housing define an insufflation gas flow channel therebetween.

US Pat. No. 10,166,347

CLOSURE ASSEMBLY FOR A MEDICAL DEVICE

1. A closure assembly for a medical device structured to provide an indication of tampering, said closure assembly comprising:an outer sleeve including an indicator window,
an end cap connected to said sleeve and movable there with, said end cap including an indicator shield,
a tip cap movably retained within said sleeve and including an indicator member removably connected to said tip cap,
said indicator member movable with said tip cap, within said outer sleeve, between at least a first retained position and a detached position,
said first retained position comprising said indicator member disposed in visually observable relation with said indicator window,
said first retained position further comprising said indicator member positioned in a visually obscuring relation to said indicator shield, relative to said indicator window,
said detached position comprising said indicator member removed from said tip cap, and
said detached position further comprising said indicator shield disposed in a viewable position within said outer sleeve, relative to said indicator window.

US Pat. No. 10,166,346

BRUISELESS CANNULA

Q-MED AB, Uppsala (SE)

1. A needle device configured for an injection apparatus, wherein said needle device comprises:a housing configured to be mounted to an injector, said housing comprising a first housing element provided towards a proximal end of said needle device and a second housing element provided towards a distal end of said needle device;
a cutting element arranged at a proximal end of said first housing element, said cutting element having a sharp proximal end;
a cannula fitted to the second housing element, said cannula having a blunt proximal end; and
an opening for said cannula provided at the proximal end of the first housing element,
wherein the first housing element and the second housing element are moveable relative to each other between an extended position and a compressed position,
wherein the proximal end of the cannula does not extend beyond the proximal end of the cutting element when the first and second housing elements are in the extended position,
wherein the cannula extends through the opening of the first housing element and past the proximal end of the cutting element when the first and second housing elements are in the compressed position, and
wherein the first housing element is provided within the second housing element, and a resilient member is provided within the housing and biases the first housing element and the second housing element in a direction from the compressed position towards the extended position.

US Pat. No. 10,166,345

SAFETY SYRINGE AND NEEDLE SHIELD

ULTIMED, INC., Exclesior...

1. A safety syringe comprising:a barrel having a distal end and a proximal end;
a plunger sealingly slidable within the barrel;
a collar having proximal and distal ends;
a hollow needle attached to the distal end of the barrel; and
an elongate generally tubular needle shield which is moveable over the barrel from a first proximally retracted configuration in which a distal portion of the hollow needle is exposed to a second distally extended configuration in which the hollow needle is fully within the elongate generally tubular needle shield, said elongate generally tubular needle shield having a proximal end, a distal end, a lumen therebetween, and a longitudinal axis,
wherein the hollow needle is attached to the barrel via a generally tubular needle hub integrally formed with the distal end of the barrel, said generally tubular needle hub having disposed about its external surface a plurality of ribs adapted to join the collar to the generally tubular needle hub;
wherein each rib of the plurality of ribs includes an at least partially relieved circumferential region;
further wherein the collar is adapted to be slidably received within the elongate generally tubular needle shield and to be prevented from being withdrawn proximally therefrom.

US Pat. No. 10,166,344

INJECTION NEEDLE ASSEMBLY

SHL GROUP AB, Nacka Stra...

1. An injection needle assembly having opposite distal and proximal ends, comprising:(a) a tubular needle cover comprising,
an open distal end having an inner diameter;
an inner circumferential surface having,
a plurality of axially extending ledges; and
a first thread having a first pitch in a first direction;
(b) a tubular needle holder comprising,
an injection needle; and
an outer circumferential surface having two separate engagement devices, the first engagement device comprising cut-outs configured to engage the axially extending ledges of the needle cover and the second engagement device comprising a second thread having a second pitch in a second direction; and
(c) a tubular cap comprising,
an outer circumferential surface having a third thread that engages the first thread of the needle cover, a central passage having a diameter larger than the outer circumferential surface of the tubular needle holder and a fourth thread configured to engage the second thread of the needle holder, wherein the third thread is configured to threadedly engage a proximal end of a container attachment device that operatively connects to a proximal end of a medicament container,
wherein the inner diameter of the open distal end of the needle cover completely encloses the needle holder and the cap, where a protective cover seals the open distal end to maintain sterility of the needle.

US Pat. No. 10,166,343

NOISE EVIDENT TAMPER CAP

1. A noise tamper evident cap assembly for a medical injection device comprising:a sleeve assembly comprising at least one side wall, said side wall forming circumferentially around a tip cap, and being permanently affixed to a bottom cap,
at least one noise fin formed along an interior of said at least one side wall, and disposed in at least partially obstructing and overlying relations relative to a bottom portion of said tip cap,
said tip cap being removably connected to said bottom cap via an engagement mechanism, said bottom portion of said tip cap interacting with said at least one noise fin upon removal of said tip cap from said sleeve assembly creating an audio indicator to a user, and
said bottom cap structured and dimensioned to enclose a dispensing portion of the medical injection device.

US Pat. No. 10,166,341

MEDICAMENT DELIVERY DEVICE

Carebay Europe Ltd, Slie...

1. A medicament delivery device having a proximal end and a distal end, the medicament delivery device comprising:a front housing and a rear housing interconnected and axially displaceable relative to each other between an extended position and a retracted position, wherein an axial displacement of the front housing relative to the rear housing sets a dose to be delivered;
a plunger rod configured to act on a plunger of a medicament container;
a drive mechanism configured to drive the plunger rod;
an actuator operably connected to each of the front and rear housings and axially movable in the front and rear housings between a proximal end position and a distal end position, wherein the actuator is biassed by a first biassing element toward the distal end position;
a drive sleeve releasably connected to the actuator and configured to act on the drive mechanism to drive the plunger rod;
a locking ring rotatably arranged at a distal end of the rear housing and in threaded connection with an outer surface of the actuator, wherein the locking ring is prevented from axial movement relative to the rear housing; and
a release button movably disposed on the rear housing between an active state and an inactive state, wherein the release button in the active state allows unidirectional rotational movement of the locking ring relative to the rear housing such that the actuator is axially movable toward the proximal end position by rotational movement of the locking ring, and the release button in the inactive state allows bidirectional rotational movement of the locking ring relative to the rear housing such that the actuator is axially movable toward the proximal end position or the distal end position by rotational movement of the locking ring.

US Pat. No. 10,166,340

APPARATUS FOR DETERMINING INFORMATION ASSOCIATED WITH REFLECTION CHARACTERISTICS OF A SURFACE

Sanofi-Aventis Deutschlan...

1. An apparatus comprising:a sensor configured to generate sensor output dependent on an intensity of light incident on the sensor, the sensor having a field of view directed at an external surface;
an illumination source configured to emit light onto the external surface;
a window configured to allow light to pass from the illumination source to the external surface and to allow light to pass to the sensor from the external surface;
a shield attached to a surface of the window or integral with a material of the window, the shield being substantially opaque to substantially all wavelengths of light detectable by the sensor and defining an aperture which limits the field of view of the sensor to light reflected from the external surface and through the window;
a light concentrator for concentrating light from the illumination source onto the external surface from which it may reflect through the window onto the sensor; and
a processor coupled to the sensor, the processor configured to use the sensor output to determine information associated with reflection characteristics of the external surface.

US Pat. No. 10,166,339

DISINFECTING CAP FOR MEDICAL CONNECTORS

Merit Medical Systems, In...

1. A disinfecting cap for accepting a needleless injection site and applying an antiseptic agent to the needleless injection site, the cap comprising:a cap body defining a chamber having an opening at a proximal end for accepting the needleless injection site, the chamber having a proximal portion and a distal portion;
an antiseptic agent disposed in the distal portion of the chamber; and
a breakable seal located in the chamber between the proximal and distal portions so as to be spaced away from the opening, the breakable seal preventing evaporation of the antiseptic agent until the needleless injection site is accepted into the cap,
wherein the cap body includes a compliant wall about the proximal portion,
wherein the compliant wall deforms when the needleless injection site is inserted into the opening so that the compliant wall engages threading elements on the outer diameter of the needleless injection site to removably hold the cap on the needleless infection site.

US Pat. No. 10,166,338

DRUG DELIVERY SYSTEM AND DEVICE WITH CAP FUNCTION

1. A drug delivery system comprising two drug delivery devices,the first drug delivery device comprising:
a first main portion (410) comprising:
a first reservoir holding a first type of drug,
a first drug outlet, and
a first drug expelling mechanism for expelling drug from the first reservoir through the first drug outlet,
a first cap (420) releasably mountable to the first main portion to enclose the first drug outlet, the first cap comprising a first user-identifiable marking indicating the first type of drug,
the second drug delivery device comprising:
a second main portion (510) comprising:
a second reservoir holding a second type of drug,
a second drug outlet, and
a second drug expelling mechanism for expelling drug from the second reservoir through the second drug outlet,
a second cap (520) releasably mountable to the second main portion to enclose the second outlet, the second cap comprising a second user-identifiable marking indicating the second type of drug,
wherein the cap and main portion of each drug delivery device comprise a pair of corresponding key structures (421, 422, 423, 411, 412, 413) preventing the first cap from being mounted on the second main portion, and the second cap from being mounted on the first main portion, and
wherein the two drug delivery devices in the system are based on the same technology platform by having at least 50% interchangeable parts.

US Pat. No. 10,166,337

HAND-ACTUATED SYRINGE WITH VACUUM CHAMBER FOR AUTO REFILL

LIEBEL-FLARSHEIM COMPANY ...

1. A method for operating a fluid delivery system that is separate from but connectable to a patient, said fluid delivery system comprising a syringe and a separate fluid source, said syringe comprising a syringe body, a plunger comprising a plunger head disposed within said syringe body, a vacuum chamber within said syringe body, a discharge chamber within said syringe body, a fill port to said discharge chamber, and a discharge port from said discharge chamber, wherein said plunger head is disposed between and separates said discharge chamber from said vacuum chamber such that said discharge chamber and said vacuum chamber are disposed on opposite sides of said plunger head within said syringe body, and wherein said plunger head fluidly isolates said vacuum chamber from said discharge chamber, said method comprising:executing a first moving step comprising moving said plunger and said plunger head relative to said syringe body and in a discharge direction to discharge a gaseous fluid from said discharge chamber, while said discharge port is disconnected from said patient, and by said plunger head interfacing with said gaseous fluid within said discharge chamber;
creating a vacuum within said vacuum chamber, wherein said vacuum within said vacuum chamber biases said plunger and said plunger head in a retraction direction that is opposite of said discharge direction, and wherein said creating a vacuum step results from said first moving step;
exerting a separate biasing force on said plunger that also biases said plunger and said plunger head in said retraction direction;
executing second moving step after said first moving step, said second moving step comprising moving said plunger and said plunger head relative to said syringe body in said retraction direction using each of said vacuum within said vacuum chamber and said separate biasing force, wherein said vacuum within said vacuum chamber and said separate biasing force exert separate forces on said plunger that each tend to move said plunger and said plunger head in said retraction direction;
drawing fluid into said discharge chamber from said fluid source and through said fill port using said second moving step;
fluidly connecting said discharge port with said patient; and
executing a third moving step after said drawing step, said third moving step comprising moving said plunger and said plunger head relative to said syringe body said discharge direction and with said plunger head interfacing with said fluid within said discharge chamber, all to discharge said fluid from said discharge chamber through said discharge port and to then inject said fluid into said patient.

US Pat. No. 10,166,336

AUTO-INJECTOR FOR RETRACTABLE PREFILLED SYRINGE

UNL Holdings LLC, New Yo...

1. An actuation mechanism for an automatic injector, comprising: a first actuation spring, a first actuation pill, a second actuation spring arranged distal to and coaxially with the first actuation spring and a second actuation pill, wherein in an initial configuration the first actuation spring resides in a compressed, energized state substantially within an upper portion of the first actuation pill, and the second actuation spring resides in a compressed, energized state between the first actuation pill and the second actuation pill, and the first actuation pill and the second actuation pill are detachably, directly connected to prevent relative movement between the first actuation pill and the second actuation pill and to maintain the second actuation spring in the compressed, energized state between the first actuation pill and the second actuation pill.

US Pat. No. 10,166,335

DRIVE ASSEMBLY FOR AN AUTOINJECTOR AND A METHOD OF ASSEMBLING AN AUTOINJECTOR

OVAL MEDICAL TECHNOLOGIES...

1. An autoinjector for use at an injection site, the autoinjector comprising a drive mechanism and a drug containing portion,the drive mechanism comprising:
a housing;
a drive means coupled to, or forming part of, the housing, the drive means comprising a resilient member;
a retaining means coupled to, or forming part of the housing, the retaining means engaging the drive means in a first position to retain the drive means in a first deformed condition; and
a coupling means for coupling with the drug containing portion, wherein the coupling means is a latch, an aperture, or a screw fitting provided on the housing,
the retaining means releasing the drive means from the first deformed condition when the retaining means is moved to a second position, and the drug containing portion being configured such that the drug containing portion retains the drive means in the second deformed condition when the retaining means is moved the second position until selective release of the drive means from the second deformed condition, wherein the drive means in the second deformed condition is expanded relative to the first deformed condition, wherein the drive means in the second deformed condition stores sufficient potential energy for driving the autoinjector, the autoinjector further comprising a release mechanism configured to selectively release the drive means from the second deformed condition when the autoinjector is to be used.

US Pat. No. 10,166,334

MEDICINE INJECTION APPARATUSES

Washington Biotech Corpor...

1. An apparatus forming a medicine injector, comprising:a barrel;
a receiving cavity within the barrel, the receiving cavity configured to receive a medicine ampule and needle assembly with an injection needle capable of being projected from the barrel to perform an injection;
a driver configured to operate within the barrel, the driver configured to move the needle into an injection position and dispense a medicine from the medicine ampule; and
a penetration controller configured to achieve a desired needle penetration depth when engaging the medicine ampule and needle assembly, the penetration controller comprising:
a control sleeve having flange lobes;
a spring located radially adjacent the control sleeve, wherein the control sleeve resides between the barrel and the spring in one cross section, and the spring includes at least one winding engaging the flange lobes; and
a cushion ring between the driver and the control sleeve.

US Pat. No. 10,166,333

METHOD FOR GENERATING A MONITORING SIGNAL USING A SUPERVISING ENTITY OR SAFETY MODULE

Roche Diabetes Care, Inc....

1. A method for generating a monitoring signal by monitoring laboratory values of a patient using a medical app, the medical app being executed on a mobile device of the patient, wherein the execution of the medical app on the mobile device of the patient is supervised by a supervising entity or safety module, the supervising entity or safety module comprising at least executable program instructions, the medical app comprising executable instructions for executing at least one sequence of processes for generating the monitoring signal, the processes comprising safety critical processes, the sequence of processes being triggered by the measurement of the laboratory values, such as the blood glucose level of the patient, the method comprising:executing a first process of the sequence of processes, wherein the execution results in the generation of an information,
forwarding the information of the executed process to the supervising entity or safety module,
evaluating the received information by the supervising entity or safety module, and
executing a second process of the sequence of processes depending on the result of the evaluation;wherein identifiers are assigned to the processes of the sequence, wherein the supervising entity or the safety module is operable to access a sequence table, wherein the sequence table comprises entries specifying allowed sequences of processes, wherein the information comprises the identifier of the second process, wherein the supervising entity or the safety module verifies whether the second process may be executed subsequent to the first process by looking up the sequence table, and wherein in response to determining that the second process is not allowed to be executed subsequent to the first process the supervising entity or safety module interrupts the execution of the sequence.

US Pat. No. 10,166,332

APPARATUS TO INJECT FLUIDS INTO BONE MARROW AND OTHER TARGET SITES

1. An apparatus for delivering a quantity of fluid to bone marrow comprising:a drive housing comprising a first portion configured to engage a driver assembly and a second portion configured to engage a cartridge assembly, the drive housing configured to receive a rotational force from the driver assembly and to transmit the rotational force to the cartridge assembly, the cartridge assembly comprising a fluid reservoir and a plunger assembly slidably disposed in the fluid reservoir, the cartridge assembly engaged with a bone penetrating needle and configured to rotate to insert the bone penetrating needle into the bone marrow;
a plunger operating assembly configured to receive a portion of the plunger assembly of the cartridge assembly;
a retractable sleeve configured to displace longitudinally relative to the drive housing and the plunger operating assembly, the retractable sleeve configured to move from a first position to a second position;
a first spring configured to bias the retractable sleeve in the first position;
a second spring configured to move the plunger operating assembly such that the plunger operating assembly moves the plunger assembly of the cartridge assembly to deliver the quantity of fluid to the bone marrow;
a first release mechanism configured to release the second spring to move the plunger operating assembly; and
a second release mechanism configured to release the engagement between the second portion of the drive housing and the cartridge assembly when the quantity of fluid is delivered to the bone marrow,
wherein the first release mechanism releases the second spring to move the plunger operating assembly when the cartridge assembly is rotated to insert the bone penetrating needle into the bone marrow and the retractable sleeve is moved to its second position.

US Pat. No. 10,166,331

AUTOMATIC CLOSED-LOOP CONTROL ADJUSTMENTS AND INFUSION SYSTEMS INCORPORATING SAME

Medtronic MiniMed, Inc., ...

1. A method of operating an infusion device comprising a motor operable to deliver a fluid to a user, the method comprising:identifying a condition of the user that is likely to influence a response to the fluid in a body of the user;
classifying the condition as exercise; and
after classifying the condition as exercise:
estimating an amount of energy expenditure during the exercise;
calculating a change in glycemic level for the user based on the amount of energy expenditure;
determining an equivalent insulin amount based on the change in glycemic level;
determining an adjusted proportional gain coefficient based on a first difference between a daily insulin requirement for the user and the equivalent insulin amount;
determining a delivery command by applying the adjusted proportional gain coefficient to a second difference between a measured glucose value obtained from a glucose sensing arrangement and a target blood glucose; and
operating the motor of the infusion device in accordance with the delivery command to deliver the fluid to the user in accordance with the adjusted proportional gain coefficient.

US Pat. No. 10,166,330

PHARMACEUTICAL DRUG DELIVERY SYSTEM

1. A pharmaceutical drug delivery system having a heater, a base comprising at least two inlets, an outlet and a passive mixing chamber having micro pin fins with heights in the range of 10 to 100 ?m, wherein the micro pin fins enhance heat transfer from the heater and promote passive mixing by generating turbulence within a flowing fluid mixture thereby providing an even distribution of temperature and concentration within the passive mixing chamber, wherein a surface portion of the base is coated with a coating material different from a material of said surface portion of the base, wherein a height of said coating material from said surface portion of the base is in nano scale, wherein distribution of said coating material throughout said surface portion of the base varies from the inlets towards the outlet such that the surface portion of the base comprises a plurality of regions R1 to RN each having a different distribution of the coating material relative to each other, thereby establishing a surface tension gradient among regions R1 to RN for promoting fluid flow towards the outlet.

US Pat. No. 10,166,329

PATCH-SIZED FLUID DELIVERY SYSTEMS AND METHODS

DEKA Products Limited Par...

15. A method of making a delivery device, the method comprising:providing a first housing portion;
providing a second housing portion comprising providing a housing structure with an internal volume configured to selectively engage with and disengage from the first housing portion;
supporting a rotatable rotor for rotation comprising supporting the rotatable rotor on the second housing portion outside of the internal volume, the rotor having at least one pad or roller for movement in an annular path with the rotation of the rotor;
providing a conduit having a flexible portion;
coupling an interior volume of a reservoir in fluid flow communication with the conduit, the interior volume of the reservoir for containing a fluid;
supporting the flexible portion of the conduit on the first housing portion and arranging the flexible portion of the conduit within at least a portion of the annular path of the at least one pad or roller to be engaged at locations along the annular path by the at least one pad or roller when the second housing portion and the first housing portion are engaged, the flexible portion of the conduit being resiliency collapsible at the locations of engagement of the at least one pad or roller to provide a pumping action as the rotor rotates while the first and second housing portions are engaged, the conduit being connectable in fluid flow communication with an injection site;
supporting a drive device on the second housing portion; and
operatively coupling the drive device to the rotor for selectively rotating the rotor to provide the pumping action while the first and second housing portions are engaged comprising extending a rotor shaft having a longitudinal axis into the interior volume of the second housing portion, operatively coupling the rotor shaft to the rotor and to the drive device to transfer drive force from the drive device to the rotor.

US Pat. No. 10,166,328

INFUSION SYSTEM WHICH UTILIZES ONE OR MORE SENSORS AND ADDITIONAL INFORMATION TO MAKE AN AIR DETERMINATION REGARDING THE INFUSION SYSTEM

ICU Medical, Inc., San C...

1. An infusion system configured to be connected to a fluid delivery line and to an infusion container containing an infusion fluid, the infusion system comprising:a pump for pumping infusion fluid from the infusion container;
at least one force sensor connected to the pump or the fluid delivery line, the at least one force sensor configured to measure force on a plunger of the pump;
at least one processor in electronic communication with the pump and the at least one force sensor;
a memory in electronic communication with the at least one processor, the memory comprising programming code for execution by the at least one processor; and
wherein the programming code is configured to cause the at least one processor to:
estimate future derived force measurement based on an application of a Kalman filter on the measured force on the plunger, wherein the estimation of future derived force measurement comprises at least one of:
determine a mean force measurement based on the measured force;
determine a variance force measurement based on the measured force; and
determine a derivative force measurement based on the measured force;
calculate a residual between the future derived force measurement and the measured force;
construct a cumulative sum control chart based on the calculated residual; and
determine air in the fluid delivery line based on the cumulative sum control chart and volume of infusion fluid pumped from the infusion container.

US Pat. No. 10,166,327

SMART CONNECTION INTERFACE

Medtronic MiniMed, Inc., ...

1. A connector interface system, comprising:a cap to connect to a reservoir to form a reservoir/cap unit for installation into an infusion pump device; and
at least two different types of detectable features arranged on the cap for detection by at least one sensor element on the infusion pump device when the reservoir of the reservoir/cap unit is received in a reservoir receptacle of the infusion pump device,
wherein the at least two different types of detectable features include at least one detectable parameter that is associated with one or more characteristics of the cap, the reservoir, a cannula, or a tubing connected between the cap and the cannula;
wherein the one or more characteristics of the cap, the reservoir, the cannula, or the tubing includes a type or identity of a manufacturer of the cap, the reservoir, the cannula or the tubing, or a size of the cap, the reservoir, the cannula or the tubing;
wherein a first of the at least two different types of detectable features includes a magnetically detectable feature that is attached to a housing of the cap; and
wherein the at least two different types of detectable features are detected by the at least one sensor element when the cap is in a proper or fully installed position within the reservoir receptacle of the infusion pump device.

US Pat. No. 10,166,326

DEVICES, SYSTEMS AND METHODS FOR DETERMINING PARAMETERS OF ONE OR MORE PHASES OF AN INJECTION PROCEDURE

BAYER HEALTHCARE LLC, Wh...

1. A system for enabling delivery of fluid in an injection procedure to be performed on a patient in connection with a diagnostic imaging procedure, the system comprising:(a) a controller operably associated with at least one pressurizing mechanism though which at least one of a first fluid and a second fluid contained within at least one fluid container is injectable into the patient, the first fluid comprising a contrast enhancing agent and adapted to enhance contrast of images obtained during the diagnostic imaging procedure, the second fluid comprising a non-contrast enhancing fluid;
(b) the controller including a programming system for programming of an injection protocol comprising a plurality of phases to effect enhancement of at least one region of interest of the patient over a scan duration of the diagnostic imaging procedure, the plurality of phases comprising a first phase in which the first fluid is to be injected and a second phase in which an admixture of the non-contrast enhancing fluid with the first fluid is to be injected;
(c) a parameter generator inclusive of an algorithm associated with the programming system, the parameter generator for determining parameters of the injection protocol based in part upon a type of the injection procedure to be performed and the algorithm according to which at least a volume of the first phase, Vol1, and a volume of the second phase, Vol2, are determined using:
Vol1=durationscan×Q1 and
Vol2=((tscan_end?propagation delay)?duration1)×Q2
where durationscan is the scan duration, Q1 is a flow rate of the first phase; duration1 is a duration of the first phase, propagation delay is a delay in propagation of the contrast enhancing fluid from an injection site to the at least one region of interest, Q2 is a flow rate of the second phase, and tscan-end is computed using:
tscan-end=ttest-bolus-peak+durationscan
where ttest-bolus-peak is a time to peak enhancement that can be obtained from an injection of a test bolus of the contrast enhanced fluid into the patient; and
(d) the parameter generator is further characterized in that the algorithm enables computation of a ratio of the admixture based on at least a peak enhancement that occurs in the at least one region of interest as a result of the injection of the test bolus.

US Pat. No. 10,166,325

PACKAGING FOR MEDICAL DEVICE AND MEDICAMENT

Sanofi, Paris (FR)

19. A method comprising:pivoting a first region and a second region of a packaging body relative to one another about a hinge of the packaging body from a storage position in which the first and second regions are spaced apart to a loading position in which the first region lies adjacent to the second region; and
causing a medicament container in the second region to be loaded into a chamber of a medicament delivery device in the first region by the first and second regions being pivoted into the loading position, the medicament delivery device comprising a delivery mechanism for administering medicament to a patient.

US Pat. No. 10,166,324

METHODS AND SYSTEM FOR TREATING ARTHRITIS

TERUMO KABUSHIKI KAISHA, ...

1. An arthritis treatment method comprising:a gel injection step of injecting a gel-like material toward a lesion area in which crystal-induced arthritis occurs, wherein the gel-like material covers the lesion area;
an instrument introducing step of causing at least one instrument having a tubular shape to communicate with the lesion area, wherein the instrument is inserted between the gel-like material and the lesion area; and
a treatment step of removing a causative agent of the crystal-induced arthritis from the lesion area by perfusion and discharge of a lavage fluid through the at least one instrument while the instrument is inserted between the gel-like material and the lesion area, and wherein the lavage fluid is prevented from spreading from the lesion area via the gel-like material covering the lesion area during the treatment step.

US Pat. No. 10,166,323

BLOOD SEPARATION BY MICROFLUIDIC ACOUSTIC FOCUSING

The Charles Stark Draper ...

1. A method of cleansing blood comprising:flowing whole blood, including plasma, a plurality of formed elements, and a plurality of undesirable particles, into an inlet of a microfluidic separation channel having a predetermined width and defined in a thermoplastic;
introducing a plurality of lipid-based capture particles into the whole blood such that the lipid-based capture particles bind to a plurality of the undesirable particles;
selecting a wavelength of a standing acoustic wave such that the predetermined width of the microfluidic separation channel is between 30% and 45% of the wavelength of the standing acoustic wave; and
applying the standing acoustic wave transverse to a direction of flow of the whole blood through the microfluidic separation channel such that the formed elements aggregate to about the axial center of the microfluidic separation channel and the capture particles aggregate along at least one wall of the microfluidic separation channel; and
cycling off the standing acoustic wave such that the duty cycle of the standing acoustic wave is between 75% and 95%.

US Pat. No. 10,166,322

GAIN IN SEPARATION PROCESSES WITH CONTROL LOOP

Terumo BCT, Inc., Lakewo...

1. A method of separating components from whole blood, the method comprising:receiving, by at least one processor, a first data related to a first platelet concentration in a first whole blood;
separating, with a separator, the first whole blood into at least a first buffy coat and first red blood cells;
determining, by the at least one processor, a first gain based on the first data related to the first platelet concentration;
using the first gain in controlling a position of an interface between the first buffy coat and the first red blood cells by using the first gain when changing a speed of a pump that pumps one or more of the first buffy coat and the first red blood cells;
receiving, by the at least one processor, a second data related to a second platelet concentration in a second whole blood, wherein the second platelet concentration is different from the first platelet concentration;
separating, with the separator, the second whole blood into a second buffy coat and second red blood cells;
determining, by the at least one processor, a second gain based on the second data related to the second platelet concentration, wherein the second gain is different from the first gain; and
using the second gain in controlling a position of an interface between the second buffy coat and the second red blood cells by using the second gain when changing a speed of the pump that pumps one or more of the second buffy coat and the second red blood cells.

US Pat. No. 10,166,321

HIGH-FLOW PORT AND INFUSION NEEDLE SYSTEMS

AngioDynamics, Inc., Lat...

1. A multi-reservoir port system, comprising:a vascular access port, including:
a housing defining first and second reservoirs,
a first septum mounted within the housing sealing the first reservoir, the first septum comprising an elastomeric material having a first septum first layer having a first durometer and a first septum second layer having a second durometer, the first septum second layer being encapsulated on all sides by the first septum first layer,
a second septum mounted within the housing sealing the second reservoir, the second septum comprising an elastomeric material having a second septum first layer having a first durometer and a second septum second layer having a second durometer, the second septum second layer being encapsulated on all sides by the second septum first layer,
an inlet stem having an inlet lumen in fluid communication with the first reservoir, and
an outlet stem having an outlet lumen in fluid communication with the second reservoir; and
a dual-lumen catheter having a proximal end, a distal end, and first and second lumens extending therebetween;
wherein the inlet stem is dimensioned to receive the first lumen at the proximal end of the catheter; and
wherein the outlet stem is dimensioned to receive the second lumen at the proximal end of the catheter.

US Pat. No. 10,166,320

DETECTING A HEATER BAG

Fresenius Medical Care Ho...

1. A peritoneal dialysis machine, comprisinga source of dialysate;
a patient line for passing dialysate to and from the patient's abdominal cavity;
a controller for delivering a quantity of dialysate to the patient's abdomen via the patient line;
a heater tray for heating a heater bag containing the dialysate before delivering it to the patient, the heater tray comprising a temperature sensor; and
at least one processor configured to receive input data from the temperature sensor and determine, based on input data received from the temperature sensor over a period of time, a status of the heater bag other than a temperature of the heater bag,
wherein the temperature sensor comprises a first thermistor and a second thermistor, wherein the processor is configured to determine whether the heater bag is positioned on the heater tray based on output of the first thermistor, and the processor is configured to determine whether the heater bag positioned on the heater tray is correctly positioned based on output of the second thermistor.

US Pat. No. 10,166,319

IMPLANTABLE PUMP SYSTEM HAVING A COAXIAL VENTRICULAR CANNULA

CorWave SA, Clichy (FR)

1. An implantable cardiovascular pump system comprising,a housing configured to be implanted in or coupled to a patient's heart;
a pump assembly disposed within the housing, the pump assembly comprising an actuator assembly coupled to a circumference of a vibrating membrane, the vibrating membrane unsupported other than at the circumference;
an outflow cannula in fluid communication with the pump assembly, the outflow cannula having an inlet and an outlet; and
an inflow cannula in fluid communication with the pump assembly, the inflow cannula having an inlet and an outlet disposed within the patient's heart,
wherein the actuator assembly is configured to cause the vibrating membrane to vibrate to transfer blood from the inlet of the inflow cannula through the housing around the actuator assembly and out the outlet of the outflow cannula, and wherein the outflow cannula is disposed coaxially within the outlet of the inflow cannula.

US Pat. No. 10,166,318

SYSTEM AND METHOD FOR CONTROLLING THE POSITION OF A LEVITATED ROTOR

TC1 LLC, Pleasanton, CA ...

1. A method of operating a blood pump, wherein the method comprises:applying a rotating magnetic field with a stator to rotate a rotor;
applying a first axial force on the rotor;
applying at least a second axial force on the rotor with the stator, wherein a combination of the first axial force and at least the second axial force suspends the rotor at a first balanced position; and
modifying a plurality of phase voltages provided to the stator to modify the second axial force such that the rotor is moved from the first balanced position to a second balanced position, wherein the second balanced position is different than the first balanced position.

US Pat. No. 10,166,317

SURGICAL HAND PIECE WITH DUAL LUMEN WORK TIP FOR USE WITH INFUSION CANNULA

SURGICAL DESIGN CORPORATI...

1. A surgical hand piece comprising:a source of ultrasonic energy;
a connecting body having a proximal end connected to said ultrasonic energy source and a distal end;
a work tip having a hub at a proximal end from which extend at least first and second tubes aligned side by side and adjacent to each other, said hub having first and second external openings, each of the at least first and second tubes having a proximal end connected to separate passages in said hub leading to the external openings, said work tip being detachably connected to said connecting body distal end and being of a material suitable for conveying the ultrasonic energy from said ultrasonic energy source to the distal end of the at least first and second tubes, wherein ultrasonic energy may be transmitted from said source of ultrasonic energy through said connecting body to said hub in order to ultrasonically vibrate both at least first and second tubes; and
a housing that covers the source of ultrasonic energy and the connecting body, but not the work tip;
wherein the work tip is detachable from the connecting body while leaving the connecting body attached to said source of ultrasonic energy, and the work tip is designed to be disposed after a single use and
wherein each of said first and second tubes has a lumen that is to receive or discharge a fluid at the proximal ends of said first and second tubes from one of first and second fluid sources that are respectively irrigation and aspiration fluids, the lumen of each of said first and second tubes being separate and spaced apart, and each said tube having an opening at its distal end through which the fluid received at or discharged from the proximal end of the respective lumen of each said tube exits from or enters the tube, with each said tube distal end opening being separate, independent of, spaced from and without being in communication with the distal end opening of the other tube, aspiration fluid flow being in one of said first and second tubes and irrigation fluid flow being in the other, and said aspiration and irrigation fluid flows being selectively and alternately reversible in said tubes.

US Pat. No. 10,166,316

CONTROLLED RANDOMIZED POROUS STRUCTURES AND METHODS FOR MAKING SAME

1. A method for fabricating a porous structure for a medical implant, the method comprising the steps of:creating a model of a porous structure, said creating step comprising causing a computing device to perform the steps of:
defining a first three dimensional space having an outer boundary and an inner volume,
placing a plurality of seed points for the first three dimensional space, wherein placing the plurality of seed points includes placing a plurality of outer seed points along the outer boundary, and placing a plurality of inner seed points in the inner volume,
moving at least one seed point from one of said plurality of outer seed points and said plurality of inner seed points,
dividing the volume of the first three dimensional space among the outer and inner seed points, thereby defining a divided volume including a plurality of divided portions, wherein each of said divided portions corresponds to one of said seed points and partially defines a boundary of said divided volume, and wherein dividing the volume includes defining each of said divided portions based upon relative positions of the corresponding seed point and at least some of the other seed points,
defining a portion of the boundary of said divided volume with a plurality of struts and one or more nodes to form a scaffold, where each strut has a first end, a second end, and a continuous elongated body between the first and second ends for each strut, and each node is an intersection of at least two struts, and
selecting at least one thickness and at least one shape for one or more struts; and
fabricating the porous structure according to the model by exposing fusible material to an energy source.

US Pat. No. 10,166,313

MEDICAL OR DENTAL MATERIAL FOR OSTEOGENESIS

MARUHA NICHIRO CORPORATIO...

1. A medical or dental material for osteogenesis, comprising a DNA/protamine/elastin complex, as an active ingredient for bone formation, comprising:(1) DNA;
(2) at least one protamine compound selected from the group consisting of protamine, a protamine derivative, and a prolamine hydrolysate; and
(3) an enzymatic degradation product of elastin having a molecular weight ranging from 350 to 3,600 Da; wherein the DNA and the at least one protamine compound form a DNA/protamine complex and the enzymatic degradation product of elastin is incorporated into the DNA/protamine complex to form the DNA/protamine/elastin complex; wherein the ratio of the DNA and the at least one protamine compound is from about 1:9 to about 9:1 by weight; and wherein about 1 to about 75 parts by weight for the enzymatic degradation product of elastin is blended with about 100 parts by weight of the DNA/protamine complex.

US Pat. No. 10,166,312

ABSORBENT ARTICLE COMPRISING A SYNTHETIC POLYMER DERIVED FROM A RENEWABLE RESOURCE AND METHODS OF PRODUCING SAID ARTICLE

1. A method for making a disposable absorbent article, the method comprising:(a) deriving a sugar from a renewable resource;
(b) fermenting the sugar to yield lactic acid using a microorganism;
(c) dehydrating the lactic acid to provide acrylic acid;
(d) polymerizing the acrylic acid to form a synthetic superabsorbent polymer; and
(e) incorporating the synthetic superabsorbent polymer into the disposable absorbent article;wherein the superabsorbent polymer has a 14C/C ratio of about 1.0×10?14 or greater and exhibits an Absorption Against Pressure (AAP) value of at least about 15 g saline per gram of superabsorbent polymer.

US Pat. No. 10,166,311

TWIST ACTIVATED DISPENSER

F-MATIC, INC., Lehi, UT ...

1. A dispenser comprising:a container for storing a fluid, the container including a cap with a breakable seal, the cap attached to the container at a first end;
a lid fixedly attached to a second end of the container, the lid having a set of vents;
an absorbing device disposed around the outside of the container and cap;
a cage structure attached to the lid and a base, the cage structure, lid and base collectively being configured to enclose the container, cap and absorbing device;
the base including a set of blades positioned inside the base and aligned with the breakable seal in the cap; and
the cage structure and base being connected with a rotational connection, when rotated with respect to each other, the cage structure and base are drawn together, collapsing the dispenser on itself and pulling the set of blades into the container and puncturing the breakable seal.

US Pat. No. 10,166,310

COMBINATION DECONTAMINATION SYSTEM FOR TRANSPORTATION ASSETS

AEROCLAVE, LLC, Winter P...

1. A decontamination system, comprising:a plurality of interconnected and insulated panels configured to form a wall and a roof and to define an interior of an enclosure configured to enclose a transportation asset;
a humidifying module in fluid communication with the interior of the enclosure and configured to raise a temperature and a humidity of the interior of the enclosure to a predetermined temperature level and a predetermined humidity level for a timed duration, wherein the humidifying module is external relative to the interior of the enclosure;
at least one insulated conduit providing fluid flow communication between the humidifying module and the interior of the enclosure via at least one first opening in the enclosure;
a dehumidifying module in fluid communication with the interior of the enclosure and configured to lower the temperature and the humidity of the interior of the enclosure from the predetermined temperature level and the predetermined humidity level to ambient levels, wherein the dehumidifying module is external relative to the interior of the enclosure; and,
at least one insulated conduit providing fluid flow communication between the dehumidifying module and the interior of the enclosure via at least one second opening in the enclosure.

US Pat. No. 10,166,309

WHITE LIGHT LEDS AND UV LEDS IN SAME LUMINAIRE FOR LIGHTING AND DISINFECTION

RayVio Corporation, Hayw...

1. A combined disinfection and lighting luminaire comprising:a first set of light emitting diodes (LEDs) and a second set of LEDs housed in a single luminaire configured for emitting light downward into a room;
the first set of LEDs generating a first light for producing white light to illuminate the room when energized;
the second set of LEDs generating invisible light in the UV range to disinfect the room when energized, wherein the light from the second set of LEDs is controllable to be either only emitted toward a ceiling of the room to disinfect the air or emitted both toward the ceiling and downward to disinfect surfaces; and
a sensor in the luminaire detecting that there are no people in the vicinity of the luminaire, wherein the sensor is coupled to automatically control the second set of LEDs;
the luminaire being configured to operate in at least two modes wherein,
the luminaire being operable in a first mode in which the first set of LEDs is energized for illuminating the room when a person is in the vicinity of the luminaire, while the second set of LEDs automatically ceases to emit the downward light and only emits the light toward the ceiling when a person is in the vicinity of the luminaire,
the luminaire being operable in a second mode in which the sensor detects no people in the vicinity of the luminaire and automatically controls the second set of LEDs to be energized to emit the light from the second set of LEDs toward the ceiling and downward to disinfect the room.

US Pat. No. 10,166,308

DISSINFECTOR AND METHOD OF DISINFECTION

READYDOCK, INC., West Ha...

1. A disinfecting station, comprising:a substantially opaque enclosure configured to receive at least one device therein through at least one openable side, the enclosure further including means for selectively sealing the at least one openable side;
at least one means for supporting the at least one device; and
at least one ultraviolet light source configured to produce disinfecting wavelengths of light only when the means for selectively sealing is in a closed position;
the at least one ultraviolet light source being activatable to produce disinfecting wavelengths of light, and configured to illuminate substantially each surface of the at least one device for a predetermined period of time when the at least one device is supported by the at least one means for supporting within the enclosure and the means for selectively sealing is in the closed position.

US Pat. No. 10,166,307

ADHESIVE DEVICE WITH ULTRAVIOLET ELEMENT

Sensor Electronic Technol...

17. A self-adhesive treatment device, comprising:a substrate having a first side and a second side, wherein the substrate comprises a light guiding layer having a first light guiding layer part and a second light guiding layer part separated from the first light guiding layer part, the first light guiding layer part and the second light guiding layer part each having a multi-layered structure;
an adhesive layer formed on the first side of the substrate that is configured to adhere to an object;
an opening formed in the second side of the substrate; and
an ultraviolet treatment system disposed in the opening that is configured to treat a surface of the object, wherein the ultraviolet treatment system comprises an ultraviolet radiation source that is configured to emit ultraviolet radiation onto the surface of the subject via the light guiding layer, wherein the ultraviolet radiation source is placed in the opening at a predetermined orientation angle to emit ultraviolet radiation onto the surface of the object at a target angle.

US Pat. No. 10,166,306

CONTAINERS AND SYSTEMS FOR PROCESSING A FLUID

Life Technologies Corpora...

1. A container comprising:a first wall comprised of a polymeric material;
a second wall comprised of a polymeric material; and
a plurality of elongated baffles, spacers or seam lines formed between the first wall and the second wall and securing together the first wall and the second wall along a majority of a length of the first wall and the second wall so as to form a plurality of separate, elongated fluid flow paths, each of the plurality of fluid flow paths being separated from the other fluid flow paths by at least one of the baffles, spacers or seam lines, each of the plurality of fluid flow paths having a first end in fluid communication with an inlet and having a second end in fluid communication with an outlet.

US Pat. No. 10,166,305

MOBILE STERILIZATION APPARATUS AND METHOD FOR USING THE SAME

PMBS, LLC, Nutley, NJ (U...

1. A mobile sterilization system comprising:a sterilization cabinet, the sterilization cabinet comprising:
a bottom panel, a top panel, two side panels, a back panel and a door configured so as to define an interior chamber;
a plurality of casters or wheels mounted to the bottom panel each having a lateral projection;
at least one of the bottom panel, top panel and two side panels having a perforated area; and
at least one filter configured to cover the perforated area; and
a transfer cart comprising:
an upper platform for receiving the sterilization cabinet, the upper platform comprising a pair of transfer cart tracks extending longitudinally along the upper platform, wherein each of the transfer cart tracks comprises a lateral projection; and
a lower support structure for supporting the upper platform and for receiving wheels;
wherein the sterilization cabinet is received on the transfer cart such that the lateral projections of the caster or wheel brackets engage the lateral projections of the transfer cart tracks to prevent side-to-side and up-and-down movement of the sterilization cabinet relative to the transfer cart.

US Pat. No. 10,166,301

CHELATED PSMA INHIBITORS

CANCER TARGETED TECHNOLOG...

1. A method for preparing a compound of the formulaor a pharmaceutically acceptable salt thereof, whereinR comprises a divalent linking group bonded to a chelating agent, wherein the divalent linking agent comprises
whereinL2 is —(CH2)tN(H)-*, wherein
t is 1 to 30; and
the *-end is attached to the chelating agent;
L3 is #-(CH)u—C(O)—, #-(CH2)u—Z-Y—C(O)—, #-C(O)—(CH2)u—C(O)— or #-C(O)—(CH2)u—Z-Y—C(O)—, wherein
u is 1 to 30; and
the # end of L3 is attached to the dibenzocyclooctyne or triazolyl group above;
Y is **-CH2CH2—(OCH2CH2)n—, wherein
n is 1-20; and
the **-end is attached to Z; and
Z is —C(O)O—, —C(O)N(R00)-, —OC(O)—, —N(R00)C(O)—, —S(O)2N(R00)-, —N(R00)S(O)2—, —OC(O)O—, —OC(O)N(R00)-, —N(R00)C(O)O—, or —N(R00)C(O)N(R00)-, wherein each R00 is independently hydrogen or C1-C6 alkyl;and —(C(O)(CH2)p—(C(O))0-1—NH)-*, whereinp is 1 30; and
the *-end is attached to L3,wherein the chelating agent is optionally associated with a PET-active or therapeutic radioisotope,the method comprisingreacting an azide terminated chelating agent optionally associated with a PET-active or therapeutic radioisotope with a DBCO-modified PMSA inhibitor of the formula

wherein
R comprises a DBCO-modified divalent linking group comprising
whereinL3 is #-(CH2)u—C(O)—, #-(CH2)u—Z-Y—C(O)—, #-C(O)—(CH2)u—C(O)— or #-C(O)—(CH2)u—Z-Y—C(O)—, wherein
u is 1 to 30;
the # end of L3 is attached to the dibenzocyclooctyne or triazolyl group above;
Y is **-CH2CH2—(OCH2CH2)n—, wherein
n is 1-20; and
the **-end is attached to Z; and
Z is —C(O)O—, —C(O)N(R00)-, —OC(O)—, —N(R00)C(O)—, —S(O)2N(R00)-, —N(R00)S(O)2—, —OC(O)O—, —OC(O)N(R00)-, —N(R00)C(O)O—, or —N(R00)C(O)N(R00)-, wherein each R00 is independently hydrogen or C1-C6 alkyl;and —(C(O)(CH2)p—(C(O))0-1—NH)-*, whereinp is 1-30; and
the *-end is attached to L3.

US Pat. No. 10,166,298

LIPIDS AND LIPID NANOPARTICLE FORMULATIONS FOR DELIVERY OF NUCLEIC ACIDS

Acuitas Therapeutics, Inc...

1. A compound having the following structure (IE):
or a pharmaceutically acceptable salt or stereoisomer thereof, wherein:
G1 and G2 are each independently unsubstituted alkylene;
G3 is unsubstituted C1-C12 alkylene;
R1 and R2 are each independently C6-C24 alkyl;
R3 is OR5, CN, —C(?O)OR4, —OC(?O)R4 or NR5C(?O)R4;
R4 is C1-C12 alkyl; and
R5 is H or C1-C6 alkyl.

US Pat. No. 10,166,296

HAPTENS OF ARIPIPRAZOLE

Janssen Pharmaceutica NV,...

1. A compound of Formula I:
wherein:
R1 is H,

R2 is H or

R3 is H; provided that either R1 or R2 must be H, and further provided that both R1 and R2 may not be H simultaneously;
m is 1, 2, 3, 4, or 5; and
n is 1, 2, 3, 4, or 5.

US Pat. No. 10,166,295

PEGYLATED OXM VARIANTS

OPKO Biologics Ltd., Kir...

1. A method for the preparation of an oxyntomodulin (OXM) conjugate represented by the structure of formula II:
wherein R2 is H or SO3H;
said method comprises:
reacting MAL-Fmoc-NHS (R2?H) represented by the following structure:

MAL-FMS-NHS (R2?SO3H) represented by the following structure:

with a resin-bound oxyntomodulin of SEQ ID NO:1, wherein the amino side chains of Lys12 and Lys30 of said resin-bound oxyntomodulin are each protected by a protecting group, to obtain a resin-bound MAL-Fmoc-protected OXM or a resin-bound MAL-FMS-protected OXM, respectively;
followed by
(b) reaction of the resin-bound MAL-Fmoc-protected OXM or the resin-bound MAL-FMS-protected OXM with sulfhydryl PEG polymer (PEG-SH) and subsequently removing the protecting groups and said resin; or
(c) removal of the protecting group and the resin to provide MAL-Fmoc-OXM and a MAL-FMS-OXM, respectively, and subsequent reaction of the MAL-Fmoc-OXM or the MAL-FMS-OXM with sulfhydryl PEG polymer (PEG-SH);
to yield the structure of formula II, wherein the amino residue of His1 of said OXM is linked to said Fmoc or FMS.

US Pat. No. 10,166,291

TARGETED NANOPARTICLES

California Institute of T...

1. A polymer conjugate comprising a polymer containing a polyol and a polymer containing a nitrophenylboronic acid,wherein the polymer containing the nitrophenylboronic acid has a linkage cleavable under reducing conditions and is conjugated to the polymer containing the polyol with a reversible borate ester linkage, and
wherein the polymer containing the polyol is derived from the coupling of a compound of Formula A with a compound of Formula B;whereinthe compound of Formula A is:
in whichthe spacer is independently selected from any organic group;
the amino acid is selected from any organic group bearing a free amine and a free carboxylic acid group;
n is 1-20; and
Z1 is independently selected from —NH2, —OH, —SH, and COOH; andthe compound of Formula B is:in whichq is a number from 1 to 20;
p is a number from 20 to 200; and
L is a leaving group.

US Pat. No. 10,166,250

BICYCLIC ARYL SPHINGOSINE 1-PHOSPHATE ANALOGS

BIOGEN MA INC., Cambridg...

1. A method for treatment of neuropathic pain in a mammal comprising administering to said mammal an effective amount of a compound of formula (IIa), (IIIa) or (IIIb):or a pharmaceutically acceptable salt thereof, wherein:each of X1, X2, X3, X4, X5, and X6, independently, is hydrogen, halo, hydroxy, nitro, cyano, alkyl, haloalkyl, cycloalkyl, halocycloalkyl, alkoxy, haloalkoxy, cycloalkoxy, halocycloalkoxy, acyl, aminoacyl, —N(RfRg), —N(Rf)SO2Rg, —SO2Rf, —S(O)2N(RfRg), —CO2Rf, trialkylamino, aryl, or heteroaryl;
W is —O—;
Cy has the formula:

wherein:
Z1 is —CH2CH2—;
Z2 is —CH2—;
Z3 is a bond;
R1a and R1b, independently, are hydrogen, halo, hydroxy, nitro, cyano, —NRfRg, alkyl, haloalkyl, cycloalkyl, cycloalkenyl, cycloalkylalkyl, cycloalkenylalkyl, heterocyclylalkyl, arylalkyl, heteroarylalkyl, alkoxy, cycloalkylalkoxy, cycloalkenylalkoxy, heterocyclylalkoxy, arylalkoxy, heteroarylalkoxy, acyl, cycloalkylacyl, cycloalkenylacyl, heterocyclylacyl, arylacyl, heteroarylacyl, thioalkyl, alkenyl, alkynyl, cycloalkenyl, heterocyclyl, aryl, or heteroaryl;
or R1a and R1b, when taken together, are C2-C5 alkylene or C2-C5 alkenylene;
R2a and R2b, independently, are hydrogen, halo, hydroxy, nitro, cyano, —NRfRg, alkyl, haloalkyl, cycloalkyl, cycloalkenyl, cycloalkylalkyl, cycloalkenylalkyl, heterocyclylalkyl, arylalkyl, heteroarylalkyl, alkoxy, cycloalkylalkoxy, cycloalkenylalkoxy, heterocyclylalkoxy, arylalkoxy, heteroarylalkoxy, acyl, cycloalkylacyl, cycloalkenylacyl, heterocyclylacyl, arylacyl, heteroarylacyl, thioalkyl, alkenyl, alkynyl, cycloalkenyl, heterocyclyl, aryl, or heteroaryl;
or R1a and R2a, when taken together, are C1-C5 alkylene or C2-C5 alkenylene;wherein R1a, R1b, R2a, and R2b are each, independently, substituted with 0-5 substituents selected from halo, hydroxy, nitro, cyano, —NRfRg, or —CO2Rf;R3 is -L1-J-L2-T1;
L1 is —C(RfRg)—;
J is —N(Rf)—; or J is

wherein
each of D1 and D3, independently, is

D2 is —[C(RfRg)]k—, —[C(RfRg)]k—N(Rf)—, —[C(RfRg)]k—O—, —N(Rf)—, or —N(Rf)—[(CRfRg)]k—; and
D4 is —[C(RfRg)]m—;
wherein k is 1 or 2; and m is 0, 1, 2, or 3;
provided that no more than 2 ring atoms of D1-D4 are N or O;
L2 is —C(RfRg)—, —C(RfG)-, —C(G)2-, —C(RfRg)—C(RfRg)—, —C(RfRg)—C(RfG)-, —C(RfRg)—C(G)2-, or a bond;
T1 is —C(O)(ORf), —C(O)N(Rf)S(O)2Rf, tetrazolyl, —S(O)2ORf, —C(O)NHC(O)—Rf, —Si(O)OH, —B(OH)2, —N(Rf)S(O)2Rf, —S(O)2NRf, —O—P(O)(ORf)ORf, or —P(O)2(ORf);
each G, independently, is hydrogen, hydroxy, a halogen, or trifluoromethyl;
each Rf, independently, is hydrogen, hydroxy, halo, alkyl, haloalkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, aryl, heteroaryl, heterocyclyl or NH2; wherein each of alkyl, cycloalkyl, cycloalkenyl, aryl, heteroaryl and heterocycle are optionally substituted with 1 to 5 substituents independently selected from the group consisting of halo, oxo, —CN, —CHO, —CG3, —OH, —NO2, alkyl, —OCG3, alkoxy, cycloalkoxy, cycloalkenoxy, amino, alkylamino, dialkylamino, acylamino, aminoacyl, alkylsulfonyl, alkylaminosulfonyl, and dialkylaminosulfonyl; and
each Rg, independently, is hydrogen, hydroxy, halo, alkyl, haloalkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, aryl, heteroaryl, or heterocyclyl; wherein each of alkyl, cycloalkyl, cycloalkenyl, aryl, heteroaryl and heterocycle are optionally substituted with 1 to 5 substituents independently selected from the group consisting of halo, oxo, —CN, —CHO, —CG3, —OH, —NO2, alkyl, —OCG3, alkoxy, cycloalkoxy, cycloalkenoxy, amino, alkylamino, dialkylamino, acylamino, aminoacyl, alkylsulfonyl, alkylaminosulfonyl, and dialkylaminosulfonyl.

US Pat. No. 10,166,249

SUBSTITUTED BICYCLIC COMPOUNDS

Bristol-Myers Squibb Comp...

1. A compound of Formula (III):
or a salt thereof, wherein:
R1 is —OH or —OP(O)(OH)2;
R2a is —(CH2)3-6CH3, —(CH2)1-4CH?CRxRx, —(CH2)1-4CH?CRx(CH2CH3), —CH?CH(CH2)1-3C(Rx)3, —CH?CH(CH2)1-3OCH3, —(CH2)1-3CH?CHCH?CRxRx, —CH?CH(CH2)1-3CH?CRxRx, —CH?CHRz, —(CH2)1-3Rz, —(CH2)1-3O(CH2)0-3Rz, —(CH2)1-3 S(CH2)0-3Rz, —CH2S(O)Rz, —CH2S(O)2Rz, —O(CH2)1-2Rz, —O(CH2)1-2O(CH2)0-2Rz, —OC(O)Rz, —(CH2)1-4O(CH2)0-9C(Rx)3, —(CH2)1-4O(CH2)0-9CF3, —(CH2)1-4CRxRxO(CH2)0-4C(Rx)3, —(CH2)1-3O(CH2)1-4CH?CRx(CH2)0-3CH3, —(CH2)1-3O(CH2)1-4CH?CRxRx, —(CH2)1-3O(CH2)1-4C (OH)RxRx, —(CH2)1-3O(CH2)1-4O(CH2)0-3CH3, —(CH2)1-3 S(CH2)0-4C(Rx)3, —(CH2)0-3O(CH2)1-4S(CH2)0-3C (Rx)3, —(CH2)1-3 S(CH2)1-4Si(CH3)3, —(CH2)1-3S(O)(CH2)0-4C(Rx)3, —(CH2)1-3S(O)2(CH2)0-4C(Rx)3, —(CH2)1-5NRxRx, —O(CH2)1-7C (Rx)3, —O(CH2)1-4O(CH2)0-4C(Rx)3, —O(CH2)1-4CH?CRX(CH2)1-3CH3, —O(CH2)1-4O(CH2)0-3C(Rx)3, —O(CH2)1-4O(CH2)1-3CH?CRxRx, —O(CH2)1-4O(CH2)1-3C?CRx, —C(O)(CH2)0-4C(Rx)3, —OC(O)(CH2)0-4C(Rx)3, —OC(O)CRxRx(CH2)0-4C(Rx)3, —OC(O)NRx(CH2)0-5C(Rx)3, —NRxC(O)NRx(CH2)0-5C(Rx)3, —C(CH3)?N—O(CH2)0-5C(Rx)3, —C(CH3)?N—O(CH2)1-2(phenyl), —C(CH3)?N—O(CH2)1-2(fluorophenyl), —C(CH3)?N—O(CH2)1-2(methoxyphenyl), phenyl, or pyridinyl;
each Rx is independently H or —CH3; and
Rz is phenyl, imidazolyl, pyrazolyl, pyridinyl, pyrimidinyl, pyrazinyl, quinolinyl, thiophenyl, thiazolyl, oxetanyl, C3-6 cycloalkyl, adamantanyl, or tetrahydropyranyl, each substituted with zero to 4 substituents independently selected from F, Cl, I, C1-4 alkyl, —O(C1-3 alkyl), —CF3, —OCF3, —(CH2)1-6OCH3, —CH2NRxRx, —C(O)NRxRx, —C(O)NRx(C1-4 alkyl), and —CH2C(O)NRxRx.

US Pat. No. 10,166,248

METHODS OF PREVENTING PLATELET ACTIVATION

Vanderbilt University, N...

1. A method of reducing the occurrence of malondiadehyde protein modification in a subject in need thereof, comprising:identifying a subject with increased platelet activation;
administering to said subject a malondiadehyde adduct formation reducing amount of a compound of the following formula:

or a pharmaceutically acceptable salt thereof;
to thereby reduce said protein modification.

US Pat. No. 10,166,246

TGR5 AGONIST COMPLEXES FOR TREATING DIABETES AND CANCER

City of Hope, Duarte, CA...

1. A complex of the following structure:

US Pat. No. 10,166,241

COMBINATION THERAPY III

Turun yliopisto, Turun y...

1. A combination of at least one type of HDAC4 silencing agent and a compound of Formula (I):
wherein
R? is H or alkyl;
R? is H or alkoxy;
R1 and R2 are H or together form oxo;
R3 and R4 are independently H, OH or together form oxo:
R5, R6, R6?, R7, and R8 are independently selected from the group consisting of H, alkyl, alkoxy, hydroxy, hydroxylalkyl, alkoxycarbonyl, or mono- and dialkylamino;
X is CH2 or O; and
n is 0 or 1.

US Pat. No. 10,166,239

TROPOMYOSIN-RELATED KINASE (TRK) INHIBITORS

Genzyme Corporation, Cam...

1. A method of treating osteoarthritis in a patient in need thereof, the method comprising administering to the patient a compound of the structure of Formula (I):
wherein:
n is 1, 2, 3, 4 or 5;
m is 0, 1, 2, 3 or 4;
Q1 is H, halo, (C6-C14)aryl, (C2-C9)heteroaryl, (C3-C10)cycloalkyl, or (C2-C9)heterocycloalkyl,
wherein the (C6-C14)aryl, (C2-C9)heteroaryl, (C3-C10)cycloalkyl, or (C2-C9)heterocycloalkyl is optionally substituted by one to four groups selected from (C1-C10)alkyl, (C2-C9)heteroalkyl, (C3-C10)cycloalkyl, (C2-C9)heterocycloalkyl, (C6-C14)aryl, (C2-C9)heteroaryl, (C1-C10)alkylamine, (C1-C10)alkyl-C(O)O—, COOH—(C1-C10)alkyl, COOH—(C3-C10)cycloalkyl, (C1-C10)alkyl-O—, —OH, —NH2, R7R8N—, R7R8N(O)C—, R7(O)CR8N—, F3C—, NC—, (C3-C10)alkyl(O)P—, (C3-C10)alkyl-S—, (C3-C10)cycloalkyl-S—, (C6-C14)aryl-S—, (C2-C9)heteroalkyl-S—, (C2-C9)heterocycloalkyl-S—, (C2-C9)heteroaryl-S—, (C3-C10)alkyl(O)S—, (C3-C10)cycloalkyl(O)S—, (C6-C14)aryl(O)S—, (C2-C9)heteroalkyl(O)S—, (C2-C9)heterocycloalkyl(O)S—, (C2-C9)heteroaryl(O)S—, (C3-C10)alkyl-O2S—, (C3-C10)cycloalkyl-O2S—, (C6-C14)aryl-O2S—, (C2-C9)heteroalkyl-O2S—, (C2-C9)heterocycloalkyl-O2S—, (C2-C9)heteroaryl-O2S—, or R7R8NO2S—,
wherein R7 and R8 is each independently H, (C1-C10)alkyl, (C2-C9)heteroalkyl, (C3-C10)cycloalkyl, (C2-C9)heterocycloalkyl, (C6-C14)aryl, or (C2-C9)heteroaryl;
Q2 is (C6-C14)aryl, (C2-C9)heteroaryl, (C3-C10)cycloalkyl, or (C2-C9)heterocycloalkyl,
wherein the (C6-C14)aryl, (C2-C9)heteroaryl, (C3-C10)cycloalkyl, or (C2-C9)heterocycloalkyl is optionally substituted by one to four groups selected from (C1-C10)alkyl, (C2-C9)heteroalkyl, (C3-C10)cycloalkyl, (C2-C9)heterocycloalkyl, (C6-C14)aryl, (C2-C9)heteroaryl, (C1-C10)alkylamine, (C1-C10)alkyl-C(O)O—, COOH—(C1-C10)alkyl, COOH—(C3-C10)cycloalkyl, (C1-C10)alkyl-O—, —OH, —NH2, R7R8N—, R7R8N(O)C—, R7(O)CR8N—, F3C—, NC—, (C3-C10)alkyl(O)P—, (C3-C10)alkyl-S—, (C3-C10)cycloalkyl-S—, (C6-C14)aryl-S—, (C2-C9)heteroalkyl-S—, (C2-C9)heterocycloalkyl-S—, (C2-C9)heteroaryl-S—, (C3-C10)alkyl(O)S—, (C3-C10)cycloalkyl(O)S—, (C6-C14)aryl(O)S—, (C2-C9)heteroalkyl(O)S—, (C2-C9)heterocycloalkyl(O)S—, (C2-C9)heteroaryl(O)S—, (C3-C10)alkyl-O2S—, (C3-C10)cycloalkyl-O2S—, (C6-C14)aryl-O2S—, (C2-C9)heteroalkyl-O2S—, (C2-C9)heterocycloalkyl-O2S—, (C2-C9)heteroaryl-O2S—, or R7R8NO2S—,
wherein R7 and R8 is each independently H, (C1-C10)alkyl, (C2-C9)heteroalkyl, (C3-C10)cycloalkyl, (C2-C9)heterocycloalkyl, (C6-C14)aryl, or (C2-C9)heteroaryl;
X is CH, N or CR9,
wherein R9 is (C1-C10)alkyl, (C2-C9)heteroalkyl, (C3-C10)cycloalkyl, (C2-C9)heterocycloalkyl, (C6-C14)aryl, (C2-C9)heteroaryl, (C1-C10)alkylamine, (C1-C10)alkyl-C(O)O—, COOH—(C1-C10)alkyl, COOH—(C3-C10)cycloalkyl, (C1-C10)alkyl-O—, —OH, or —NH2;
R1 is H, halo, (C1-C10)alkyl, (C2-C9)heteroalkyl, (C1-C10)alkylamine, or NH2;
R2 is H, halo, (C1-C10)alkyl, (C2-C9)heteroalkyl, (C1-C10)alkylamine, (C1-C10)alkyl-O—, or NH2;
R3 and R4 are each independently H, (C1-C10)alkyl, (C2-C9)heteroalkyl, (C1-C10)alkylamine, O—(C1-C10)alkyl, or NH2 or R3 and R4 are taken together with the carbon to which they are attached to form a 3 to 10 member ring,
wherein the 3 to 10 member ring is optionally substituted by one to four groups selected from (C1-C10)alkyl, (C2-C9)heteroalkyl, (C3-C10)cycloalkyl, (C2-C9)heterocycloalkyl, (C6-C14)aryl, (C2-C9)heteroaryl, (C1-C10)alkylamine, (C1-C10)alkyl-C(O)O—, COOH—(C1-C10)alkyl, COOH—(C3-C10)cycloalkyl, (C1-C10)alkyl-O—, —OH, or —NH2; and
R5 and R6 are each independently H, (C1-C10)alkyl, (C2-C9)heteroalkyl, (C1-C10)alkylamine, O—(C1-C10)alkyl, or NH2 or R5 and R6 are taken together with the carbon to which they are attached to form a 3 to 10 member ring,
wherein the 3 to 10 member ring is optionally substituted by one to four groups selected from (C1-C10)alkyl, (C2-C9)heteroalkyl, (C3-C10)cycloalkyl, (C2-C9)heterocycloalkyl, (C6-C14)aryl, (C2-C9)heteroaryl, (C1-C10)alkylamine, (C1-C10)alkyl-C(O)O—, COOH—(C1-C10)alkyl, COOH—(C3-C10)cycloalkyl, (C1-C10)alkyl-O—, —OH, or —NH2;or a pharmaceutically acceptable salt thereof.

US Pat. No. 10,166,237

COMPOUNDS AND METHODS FOR INDUCING CHONDROGENESIS

The Scripps Research Inst...

1. A method for stimulating chondrocyte proliferation and cartilage production in cartilaginous tissues in a mammal, the method comprising administering to the mammal a composition comprising a therapeutically effective amount of a compound of formula I:
wherein
each of ring A and ring B are independently selected from the group consisting of cycloalkyl, aryl and heteroaryl;
each R1 and R2 is independently selected from the group consisting of H, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 alkoxy, C1-6 heteroalkyl, halogen, C1-6 haloalkyl, C1-6 haloalkoxy, C1-6 alkyl-CN, C1-6 alkylhydroxy, —OR2a, —NR2bR2d, C1-6 alkyl-NR2bR2d, —C(O)R1a, —C(O)R2d, —C(O)OR2a, C1-6 alkyl-C(O)OR2b, —OC(O)R2b, —OC(O)OR2b, —C(O)NR2aR2b, —C(O)N(OH)R2b, —NR2bC(O)R2c, C1-6 alkyl-NR2bC(O)R2c, —NR2bC(O)OR2c, C1-6 alkyl-NR2bC(O)OR2c, —OC(O)NR2bR2c, —NR2bC(O)NR2bR2c, —NR2bC(NR2b)N R2bR2c, —C(O)NR2bC(O)R2b, C1-6 alkyl-NR2bC(O)NR2bR2c, —SR2a, —SO2R2b, —SO2OR2b,—SO2NR2bR2d, —NR2bSO2 R2b, —P(O)(OR2b)2, —B(OR2b), —CN, —NO2, —N3, heterocycloalkyl, aryl, heteroaryl, C1-6 alkyl-heterocycloalkyl, C1-6 alkyl-aryl, C1-6 alkyl-O-aryl, C1-6 alkyl-heteroaryl, and heteroaryl-aryl, and wherein the heterocycloalkyl, aryl and heteroaryl groups are optionally substituted with 1 to 2 R2a groups;
R1a is selected from the group consisting of —OR1b and —NR1bR1c;
R1b and R1c are each independently selected from the group consisting of H, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, C1-6 alkyl-aryl, and C1-6 alkyl-heteroaryl, wherein the cycloalkyl, heterocycloalkyl, aryl and heteroaryl groups are optionally substituted with from 1 to 4 Rid groups;
each R1d is independently selected from the group consisting of H, C1-6 alkyl, C1-6 alkoxy, and —NO2;
each R2a is independently selected from the group consisting of H, C2-6 alkenyl, C2-6 alkynyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, C1-6 alkyl-cycloalkyl, C1-6 alkyl-heterocycloalkyl, C1-6 alkyl-aryl and C1-6 alkyl-heteroaryl, optionally substituted with 1 to 2 R2b groups;
each R2b and R2c is independently selected from the group consisting of H, and C1-6 alkyl;
each R2d is independently selected from the group consisting of H, C1-6 alkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, C1-6 alkyl-cycloalkyl, C1-6 alkyl-heterocycloalkyl, C1-6 alkyl-aryl and C1-6 alkyl-heteroaryl, each optionally substituted with 1 to 2 R2b groups;
each of L1 and L2 are independently selected from the group consisting of a bond, C1-6 alkylene, C2-6 alkenylene, C1-6 alkylene-O—, —O—C1-6 alkylene, C1-6 alkylene-NR3a—, —NR3a—C1-6 alkylene, —C(O)—, C1-6 alkylene-C(O)—, —C(O)—C1-6 alkylene-NH—, —NH—C1-6 alkylene-C(O)—, —C(O)N H—, —NHC(O)—, C1-6 alkylene-NHC(O)—, —SO2NH—, —NHSO2—, —NHC(O)NH—, cycloalkylene, —N?N—, and —C(R3a)?N(R3c)—, wherein the alkylene group is optionally substituted with from 1-4 R3b groups; R3a is selected from the group consisting of H, and C1-6 alkyl;
each R3b is independently selected from the group consisting of H, C1-6 alkyl, halogen, —OR3a and —NR3aR3a;
R3c is absent or —OH;
alternatively, L2 is combined with R1, L1 is combined with L2, L1 is combined with R2, two R1 groups on adjacent ring atoms, or two R2 groups on adjacent ring atoms are combined to form a 5-6 membered heterocycloalkyl with from 1 to 3 heteroatoms selected from N, O and S, or a 5-6 membered heteroaryl with from 1 to 3 heteroatoms selected from N, O and S, and optionally substituted with from 1 to 3 groups selected from the group consisting of H, C1-6 alkyl and oxo;
subscripts m and n are each an integer from 1 to 3;
wherein:
(a) L1 is a bond, L2 is —C(O)NH—, ring B is phenyl, and at least one R2 is —CN or phenyl, or
(b) at least one R1 is —C(O)OH, ring A is phenyl, L2 is —C(O)NH—, and L1 is a bond or C1-6 alkylene, or
(c) each of ring A and ring B is phenyl, at least one R1 is —C(O)OH or combined with L2, and at least one R2 is selected from the group consisting of H, —CN and —C(O)OH;
wherein when R1 is —CO2H, subscript n is 1, ring A is phenyl, L2 is —C(O)NH—, L1 is a bond, ring B is phenyl, subscript m is 1, and R2 is phenyl, then the phenyl of R2 is substituted with C1-6 alkyl,
or salts and isomers thereof, thereby stimulating chondrocyte proliferation and cartilage production in the cartilaginous tissues in the mammal.

US Pat. No. 10,166,236

PHARMACEUTICAL FORMULATIONS COMPRISING SUBSTITUTED PYRAZOLO[5,1-C]PYRIDO[4,3-E][1,2,4]TRIAZINES FOR TREATING LYSOSOMAL STORAGE DISORDERS

Perlara PBC, South San F...

1. A method for treating a lysosomal storage disorder in a subject in need thereof comprising administering to the subject a therapeutically effective amount of a pharmaceutical formulation comprising a pharmaceutically acceptable excipient and a compound of Formula I:
or a pharmaceutically acceptable salt thereof, wherein:
R1 is —(C2-C6 alkylidene)-NR6R7, —(C2-C6 alkylidene)-X1—(C2-C6 alkylidene)-NR6R7, or —(C3-C6 cycloalkylidene)-NR6R7, each of which is optionally substituted with one or more groups independently selected from C1-C6 alkyl, C3-C6 cycloalkyl, halogen, —OH, alkoxy, —NO2, amino, —CN, —COOH, —COOR8, and amido;
R2, R3, R4, and R5 are independently selected from H, halogen, —CN, amino, —NO2, C1-C6 alkyl, C3-C6 cycloalkyl, alkoxy, —(C1-C6 alkylidene)-X2—(C1-C6 alkyl), aryl, heterocyclyl, heteroaryl, aralkyl, heteroarylalkyl, and heterocyclylalkyl, wherein the amino, C1-C6 alkyl, C3-C6 cycloalkyl, alkoxy, —(C1-C6 alkylidene)-X2—(C1-C6 alkyl), aryl, heterocyclyl, heteroaryl, aralkyl, heteroarylalkyl, and heterocyclylalkyl are optionally substituted with one or more groups independently selected from C1-C6 alkyl, C3-C6 cycloalkyl, halogen, —OH, -alkoxy, —NO2, amino, —CN, —COOH, —COOR9, and amido;
X1 and X2 are independently selected from null, —O—, —S—, —SO2—, —(C?O)—, —N(R11)—, and —C(O)N(R12)—;
R6 and R7 are independently selected from H, C1-C6 alkyl, and C3-C6 cycloalkyl; or R6, R7, and the nitrogen to which they are attached join together to form a heterocyclic ring;
R8 and R9 are independently selected from H, C1-C6 alkyl, and C3-C6 cycloalkyl; and
R11 and R12 are independently selected from H, C1-C6 alkyl, and C3-C6 cycloalkyl, wherein the C1-C6 alkyl and C3-C6 cycloalkyl are optionally substituted with one or more groups independently selected from halogen, —OH, amino, alkoxy, —CN, and —NO2;
and wherein the lysosomal storage disorder is Niemann Pick type A disease, Niemann Pick type C disease, Gaucher type 1 disease, or Gaucher type 2 disease.

US Pat. No. 10,166,234

PHARMACEUTICAL PREPARATION COMPRISING PHENYLALANINE DERIVATIVE

EA Pharma Co., Ltd., Tok...

1. A pharmaceutical preparation, comprising:the compound of the formula (A) or a pharmaceutically acceptable salt thereof, which is dispersed in a matrix consisting of a water-soluble high molecular weight substance:

and
Crospovidone,
wherein the compound of the formula (A) or the pharmaceutically acceptable salt thereof is included in the pharmaceutical preparation in an amount of not less than 100 mg.

US Pat. No. 10,166,232

ARYLAMIDE COMPOUNDS AND COMPOSITIONS AND USES THEREOF

Innovation Pharmaceutical...

1. A pharmaceutical composition comprising a compound having the formula:
or a pharmaceutically acceptable salt thereof, and water.

US Pat. No. 10,166,229

COMPOUNDS AND METHODS FOR THE TREATMENT OF CANCER

The Board of Trustees of ...

1. A method for treating cancer comprising administering to a patient having cancer a therapeutically effective amount of a compound of formula ZZ:whereineach R is independently hydrogen, halogen, allyl, or short alkyl;
n is 1 or 2;
R2 is hydrogen or short alkyl;
R3 is hydrogen, halogen, alkyl, haloalkyl, allyl, alkenyl, alkenol, alkanol, or haloalkenyl;
R4 and R5 are N; or R4 is N and R5 is C; or R4 and R5 is C; and
A is oxygen or sulfur;or a salt thereof;wherein the cancer is thereby treated.

US Pat. No. 10,166,226

CGRP RECEPTOR ANTAGONISTS

Heptares Therapeutics Lim...

1. A method of preparing a compound of formula (I), or a salt thereof or an optical isomer thereof, the method comprising:reacting a compound of formula (V) wherein Ar1 is an optionally substituted 5 membered heterocyclic ring containing at least two nitrogen atoms,
with a compound of formula (III), or an optical isomer thereof, wherein R1 is H or F,
under conditions effective to provide the compound of formula (I), or a salt thereof or an optical isomer thereof, wherein R1 is H or F and Ar1 is an optionally substituted 5 membered heterocyclic ring containing at least two nitrogen atoms:

US Pat. No. 10,166,223

PHARMACEUTICAL COMPOSITION FOR PREVENTION OR TREATMENT OF DIABETES OR FATTY LIVER COMPRISING CYP4A INHIBITOR

KOREA BASIC SCIENCE INSTI...

1. A method for treating diabetes or fatty liver in a subject in need thereof, the method comprising administering to a subject in need thereof an effective amount of a composition comprising a compound represented by the following Formula 1 or a pharmaceutically acceptable salt thereof as an active ingredient:
wherein
R is phenyl or a 5 or 6 membered heteroaryl containing at least a heteroatom selected from the group consisting of N, O and S, which is unsubstituted or substituted with at least a substituent;
the substituent is at least a substituent selected from the group consisting of linear or branched C1-C6 alkyl; heterocyclic ring or heteroaryl ring containing one or more heteroatoms in the ring and substituted with C1-C6 alkyl or C1-C6 alkylcarbonyl; C2-C4 alkenylene substituted with halogen-substituted phenyl; C1-C6 alkyloxycarbonyl; C1-C6 alkyloxy; halogen; C1-C6 alkyloxy substituted with C1-C6 alkylamino group; hydroxycarbonyl C1-C6 alkyl; C1-C6 alkylamino; phenyl; phenyl substituted with at least a substituent selected from the group consisting of linear or branched C1-C6 alkyl, linear or branched C1-C6 alkyloxy, linear or branched C1-C6 alkyloxycarbonyl, halogen atoms, and alkyl substituted with one or more fluoro atoms; phenoxy; phenoxy substituted with one or more substituents selected from the group consisting of linear or branched C1-C6 alkyl, halogen atoms, and linear or branched C1-C6 alkyloxy; aminosulfonyl; halo; cyano; acetyl; nitro; ethynyl; hydroxy; morpholino; naphthyl; thienyl; pyridyl; tetrahydrofuranyl; indolyl; indolyl substituted with linear or branched C1-C6 alkyloxy; dihydrobenzooxynil; and furylmethylsulfanyl; and
the aryl, heterocyclic ring and heteroaryl ring may be a heterocyclic structure in which two or more rings are fused, respectively, and may contain a carbonyl group in the ring.

US Pat. No. 10,166,222

PIPERIDINE-2, 6-DIONE DERIVATIVES AND THEIR USE AS TUMOR NECROSIS FACTOR INHIBITORS

Tianjin Hemay Bio-Tech Co...

1. A method for treating an infectious disease in a patient, comprising administering a compound of formula (I) or an organic or inorganic salt thereof as an active pharmaceutical ingredient to the patient,whereinn is 1, 2, 3, 4, 5 or 6,
R1 represents from one to four of the same or different substituents selected from F, Cl, Br, C1-4 alkyl, OH, OC1-4 alkyl, NO2, NHC(O)C1-4 alkyl, NH2, NH(C1-4 alkyl), N(C1-4 alkyl)2;
R2 represents OR3, NR3R4, or N(R3)COR4; and
R3 and R4 represent independently and at each occurrence H or C1-4 alkyl.

US Pat. No. 10,166,221

FORMULATIONS OF AN LSD1 INHIBITOR

Incyte Corporation, Wilm...

1. A pharmaceutical formulation in solid oral dosage form comprising:(a) an inhibitor of LSD1 which is Compound 1 di-tosylate salt of the formula:

or a solvate or hydrate thereof, and
(b) an organic acid selected from the group consisting of ascorbic acid, citric acid, fumaric acid, lactic acid, maleic acid, malic acid, sorbic acid, succinic acid, tartaric acid, and hydrates or solvates thereof, wherein the organic acid is from about 1% and to about 50% by weight.

US Pat. No. 10,166,220

FEXOFENADINE MICROCAPSULES AND COMPOSITIONS CONTAINING THEM

ADARE PHARMACEUTICALS S.R...

1. A process for preparing a pharmaceutical composition comprising a water suspendable co-granulate of immediate release microcapsules and at least one inactive ingredient, wherein said microcapsules comprise fexofenadine coated with a water-insoluble polymer, wherein said process comprises the steps of: (a) dissolving a water-insoluble polymer in an organic solvent; (b) suspending fexofenadine in said organic solvent; (c) applying a coating of said water-insoluble polymer onto said fexofenadine by phase separation to provide microcapsules; (d) separating said microcapsules from said organic solvent and (e) co-granulating the microcapsules with at least one inactive ingredient to provide a water suspendable co-granulate.

US Pat. No. 10,166,218

3-(1H-INDOL-2-YL)-1H-PYRAZOLO[3,4-C]PYRIDINES AND THERAPEUTIC USES THEREOF

Samumed, LLC, San Diego,...

1. A compound, or a pharmaceutically acceptable salt thereof, of Formula I:
wherein:
R1 and R4 are independently selected from the group consisting of H and halide;
R3 is selected from the group consisting of -heteroaryl optionally substituted with 1-4 R6 and -heterocyclyl optionally substituted with 1-10 R7;
X is CR5 or N;
R5 is selected from the group consisting of H, -heteroaryl optionally substituted with 1-4 R8, -heterocyclyl optionally substituted with 1-10 R9, and -aryl optionally substituted with 1-5 R10;
each R6 is independently selected from the group consisting of halide, —(C1-6 alkyl), —(C2-6 alkenyl), —(C2-6 alkynyl), —(C1-4 alkylene)pheterocyclyl optionally substituted with 1-10 R11, —(C2-4 alkenylene)pheterocyclyl optionally substituted with 1-10 R11, —(C2-4 alkynylene)pheterocyclyl optionally substituted with 1-10 R11, —(C1-4 alkylene)pcarbocyclyl optionally substituted with 1-12 R12, —(C2-4 alkenylene)pcarbocyclyl optionally substituted with 1-12 R12, —(C2-4 alkynylene)pcarbocyclyl optionally substituted with 1-12 R12, —(C1-4 alkylene)paryl optionally substituted with 1-5 R13, —(C2-4 alkenylene)paryl optionally substituted with 1-5 R13, —(C2-4 alkynylene)paryl optionally substituted with 1-5 R13, —NHC(?O)R14, —NR15R16, —(C1-6 alkylene)NR17R18, —(C2-6 alkenylene)NR17R18, —(C2-6 alkynylene)NR17R18, and —(C1-4 alkylene)pOR24;
each R7 is independently selected from the group consisting of —(C1-4 alkyl), —(C2-4 alkenyl), —(C2-4 alkynyl), halide, —CF3, and —CN;
each R8 is independently selected from the group consisting of —(C1-6 alkyl), —(C2-6 alkenyl), —(C2-6 alkynyl), halide, —CF3, —OCH3, —CN, and —C(?O)R19;
each R9 is independently selected from the group consisting of —(C1-6 alkyl), —(C2-6 alkenyl), —(C2-6 alkynyl), halide, —CF3, —CN, and —OCH3;
each R10 is independently selected from the group consisting of —(C1-6 alkyl), —(C2-6 alkenyl), —(C2-6 alkynyl), halide, —CF3, —CN, —(C1-6 alkylene)pNHSO2R19, —(C2-6 alkenylene)pNHSO2R19, —(C2-6 alkynylene)pNHSO2R19, —NR15(C1-6 alkylene)NR15R16, —NR15(C2-6 alkenylene)NR15R16, —NR15(C2-6 alkynylene)NR15R16, —(C1-6 alkylene)pNR15R16, —(C2-6 alkenylene)pNR15R16, —(C2-6 alkynylene)pNR15R16, and —OR27;
each R11 is independently selected from the group consisting of amino, —(C1-4 alkyl), —(C2-4 alkenyl), —(C2-4 alkynyl), halide, —CF3, and —CN;
each R12 is independently selected from the group consisting of —(C1-4 alkyl), —(C2-4 alkenyl), —(C2-4 alkynyl), halide, —CF3, and —CN;
each R13 is independently selected from the group consisting of —(C1-4 alkyl), —(C2-4 alkenyl), —(C2-4 alkynyl), halide, —CF3, and —CN;
each R14 is independently selected from the group consisting of —(C1-9 alkyl), —(C1-4 haloalkyl), —(C2-9 alkenyl), —(C2-9 alkynyl), -heteroaryl optionally substituted with 1-4 R20, -aryl optionally substituted with 1-5 R21, —CH2aryl optionally substituted with 1-5 R21, -carbocyclyl optionally substituted with 1-12 R22, —CH2carbocyclyl optionally substituted with 1-12 R22, —(C1-4 alkylene)pNR25R26, —(C2-4 alkenylene)pNR25R26, —(C2-4 alkynylene)pNR25R26, -heterocyclyl optionally substituted with 1-10 R23, and —CH2heterocyclyl optionally substituted with 1-10 R23;
each R15 is independently selected from the group consisting of H, —(C1-6 alkyl), —(C2-6 alkenyl), and —(C2-6 alkynyl);
each R16 is independently selected from the group consisting of H, —(C1-6 alkyl), —(C2-6 alkenyl), —(C2-6 alkynyl), —CH2aryl optionally substituted with 1-5 R21, and —CH2carbocyclyl optionally substituted with 1-12 R22;
each R17 is independently selected from the group consisting of H, —(C1-6 alkyl), —(C2-6 alkenyl), and —(C2-6 alkynyl);
each R18 is independently selected from the group consisting of H, —(C1-6 alkyl), —(C2-6 alkenyl), —(C2-6 alkynyl), —CH2aryl optionally substituted with 1-5 R21, and —CH2carbocyclyl optionally substituted with 1-12 R22;
each R19 is independently selected from the group consisting of —(C1-6 alkyl), —(C2-6 alkenyl), and —(C2-6 alkynyl);
each R20 is independently selected from the group consisting of —(C1-4 alkyl), —(C2-4 alkenyl), —(C2-4 alkynyl), halide, —CF3, and —CN;
each R21 is independently selected from the group consisting of —(C1-4 alkyl), —(C2-4 alkenyl), —(C2-4 alkynyl), halide, —CF3, and —CN;
each R22 is independently selected from the group consisting of —(C1-4 alkyl), —(C2-4 alkenyl), —(C2-4 alkynyl), halide, —CF3, and —CN;
each R23 is independently selected from the group consisting of —(C1-4 alkyl), —(C2-4 alkenyl), —(C2-4 alkynyl), halide, —CF3, and —CN;
R24 is selected from the group consisting of H, —(C1-6 alkyl), —(C2-6 alkenyl), —(C2-6 alkynyl), —(C1-4 alkylene)pheterocyclyl optionally substituted with 1-10 R23, —(C2-4 alkenylene)pheterocyclyl optionally substituted with 1-10 R23, —(C2-4 alkynylene)pheterocyclyl optionally substituted with 1-10 R23, —(C1-4 alkylene)pcarbocyclyl optionally substituted with 1-12 R22, —(C2-4 alkenylene)pcarbocyclyl optionally substituted with 1-12 R22, —(C2-4 alkynylene)pcarbocyclyl optionally substituted with 1-12 R22, —(C1-4 alkylene)paryl optionally substituted with 1-5 R21, —(C2-4 alkenylene)paryl optionally substituted with 1-5 R21, —(C2-4 alkynylene)paryl optionally substituted with 1-5 R21, —(C1-6 alkylene)pNR25R26, (C2-4 alkenylene)pNR25R26, and —(C2-4 alkynylene)pNR25R26;
each R25 is independently selected from the group consisting of H, —(C1-6 alkyl), —(C2-6 alkenyl), and —(C2-6 alkynyl);
each R26 is independently selected from the group consisting of H, —(C1-6 alkyl), —(C2-6 alkenyl), and —(C2-6 alkynyl);
R27 is selected from the group consisting of H, —(C1-6 alkyl), —(C2-6 alkenyl), —(C2-6 alkynyl), —(C1-4 alkylene)pheterocyclyl optionally substituted with 1-10 R23, —(C2-4 alkenylene)pheterocyclyl optionally substituted with 1-10 R23, —(C24 alkynylene)pheterocyclyl optionally substituted with 1-10 R23, —(C1-6 alkylene)pNR25R26, —(C2-6alkenylene)pNR25R26, and —(C2-6 alkynylene)pNR25R26; and
each p is independently an integer of 0 or 1.

US Pat. No. 10,166,216

SUBSTITUTED TRIAZOLES USEFUL AS AXL INHIBITORS

Rigel Pharmaceuticals, In...

1. A method of inhibiting Axl activity in a cell, wherein the method comprises contacting the cell with an effective amount of a compound of formula (Ia1):
wherein:
R1, R4 and R5 are each independently selected from the group consisting of hydrogen, alkyl, aryl, aralkyl, —C(O)R8 and —C(O)N(R6)R7;
R2a is —R10a—N(R6a)R7a where R6a and R7a, together with the common nitrogen to which they are both attached, form an optionally substituted pyrrolidinyl or an optionally substituted piperidinyl, and R10a is an optionally substituted straight or branched alkylene chain;
R2g is selected from the group consisting of hydrogen, halo, alkyl, haloalkyl, aryl, aralkyl, —R9g—C(O)R8g, —R9g—C(O)OR8g, —R9g—N(R6g)R7g and —R9g—C(O)N(R6g)R7g, where each R6g, R7g and R8g is independently selected from the group consisting of hydrogen, alkyl, haloalkyl, aryl and aralkyl, and each R9g is independently selected from the group consisting of a direct bond and an optionally substituted straight or branched alkylene chain;
R3 is selected from the group consisting of aryl and heteroaryl, where the aryl and the heteroaryl are each independently optionally substituted by one or more substituents selected from the group consisting of oxo, thioxo, cyano, nitro, halo, haloalkyl, alkyl, cycloalkyl, cycloalkylalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted heteroaryl, optionally substituted heteroarylalkyl, optionally substituted heteroarylalkenyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heterocyclylalkenyl, —R9—OR8, —R9—O—R10—OR8, —R9—O—R10—O—R10—OR8, —R9—O—R10—CN, —R9—O—R10—C(O)OR8, —R9—O—R10—C(O)N(R6)R7, —R9—O—R10—S(O)pR8 (where p is 0, 1 or 2), —R9—O—R10—N(R6)R7, —R9—O—R10—C(NR11)N(R11)H, —R9—OC(O)—R8, —R9—N(R6)R7, —R9—C(O)R8, —R9—C(O)OR8, —R9—C(O)N(R6)R7, —R9—N(R6)C(O)OR8, —R9—N(R6)C(O)R8, —R9—N(R6)S(O)tR8 (where t is 1 or 2), —R9—S(O)tOR8 (where t is 1 or 2), —R9—S(O)pR8 (where p is 0, 1 or 2), and —R9—S(O)tN(R6)R7 (where t is 1 or 2);
each R6 and R7 is independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, haloalkyl, haloalkenyl, haloalkynyl, hydroxyalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted aralkenyl, optionally substituted aralkynyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted cycloalkylalkenyl, optionally substituted cycloalkylalkynyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heterocyclylalkenyl, optionally substituted heterocyclylalkynyl, optionally substituted heteroaryl, optionally substituted heteroarylalkyl, optionally substituted heteroarylalkenyl, optionally substituted heteroarylalkynyl, —R10—OR8, —R10—CN, —R10—NO2, —R10—N(R8)2, —R10—C(O)OR8 and —R10—C(O)N(R8)2, or any R6 and R7, together with the common nitrogen to which they are both attached, form an optionally substituted N-heteroaryl or an optionally substituted N-heterocyclyl;
each R8 is independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, haloalkyl, haloalkenyl, haloalkynyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted aralkenyl, optionally substituted aralkynyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted cycloalkylalkenyl, optionally substituted cycloalkylalkynyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heterocyclylalkenyl, optionally substituted heterocyclylalkynyl, optionally substituted heteroaryl, optionally substituted heteroarylalkyl, optionally substituted heteroarylalkenyl, optionally substituted heteroarylalkynyl;
each R9 is independently selected from the group consisting of a direct bond, an optionally substituted straight or branched alkylene chain, an optionally substituted straight or branched alkenylene chain and an optionally substituted straight or branched alkynylene chain;
each R10 is independently selected from the group consisting of an optionally substituted straight or branched alkylene chain, an optionally substituted straight or branched alkenylene chain and an optionally substituted straight or branched alkynylene chain; and
each R11 is hydrogen, alkyl, cyano, nitro or —OR8;
as an isolated stereoisomer or mixture thereof, or a pharmaceutically acceptable salt thereof.

US Pat. No. 10,166,215

SUBSTITUTED BICYCLIC COMPOUNDS AS BROMODOMAIN INHIBITORS

Zenith Epigenetics Ltd., ...

1. A method for inhibiting BET proteins in a mammal, comprising administering a therapeutically effective amount of a compound of formula:or a stereoisomer, tautomer, pharmaceutically acceptable salt, or hydrate thereof, wherein:the A-B bicyclic ring is optionally substituted with one or more groups independently selected from deuterium, —NH2, —OH, alkyl(C1-C6), thioalkyl(C1-C6), and alkoxy(C1-C9);
D1 is selected from isoxazole and pyrazole optionally substituted with one or more groups independently selected from deuterium, alkyl(C1-C4), —OH, alkoxy(C1-C4), amino, halogen, amide, —CF3, CN, —OCF3, —N3, ketone (C1-C4), —S(O)Alkyl(C1-C4), —SO2alkyl(C1-C4), -thioalkyl(C1-C4), carboxyl, and/or ester,
wherein said alkyl(C1-C4), alkoxy(C1-C4), amino, amide, ketone (C1-C4), —S(O)Alkyl(C1-C4), —SO2alkyl(C1-C4), -thioalkyl(C1-C4), and ester may be optionally substituted with F, Cl, Br, —OH, —NH2, —NHMe, —NMe2, —OMe, —SMe, oxo, and/or thio-oxo;
X is optionally present, and if present, is selected from —(NH)—, —O—, —NHCRxRy—, —NHSO2—, —CRxRyNH—, or —NH2 and R3 is absent; and
R3 is selected from isoxazolyl, oxazolyl, pyrazolyl, pyridyl, pyridonyl, thiazolyl, isothiazolyl, pyrimidinyl, thiozolyl, pyrazinyl, pyridazinyl, azetidinyl, pyrrolidyl, piperidinyl, morpholinyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, and phenyl, optionally substituted with one or more groups independently selected from deuterium, alkyl(C1-C4), —OH, alkoxy(C1-C4), amino, halogen, amide, —CF3, CN, —OCF3, —N3, ketone (C1-C4), —S(O)Alkyl(C1-C4), —SO2alkyl(C1-C4), -thioalkyl(C1-C4), carboxyl, and/or ester,
wherein said alkyl(C1-C4), alkoxy(C1-C4), amino, amide, ketone (C1-C4), —S(O)Alkyl(C1-C4), —SO2alkyl(Ci-C4), -thioalkyl(C1-C4), and ester may be optionally substituted with F, Cl, Br, —OH, —NH2, —NHMe, —NMe2, —OMe, SMe, oxo, and/or thio-oxo.

US Pat. No. 10,166,214

SOMATOSTATIN RECEPTOR SUBTYPE 4 (SSTR4) AGONISTS

Centrexion Therapeutics C...

1. A method for the treatment of pain selected from the group consisting of visceral pain, phantom limb pain, stump pain, and pain due to rheumatoid arthritis, which comprises administering to a host suffering from said pain a therapeutically effective amount of a compound of Formula I to treat the pain, wherein Formula I is represented by:
or a salt thereof, wherein:
A is selected from the group consisting of H and C1-6-alkyl;
R1 and R2 are independently selected from the group consisting of H, C1-6-alkyl and C3-6-cycloalkyl, wherein at least one of R1 or R2 is C1-6-alkyl or C3-6-cycloalkyl, and the C1-6-alkyl or the C3-6-cycloalkyl is optionally substituted with halogens or MeO—;
W is a mono- or bicyclic heteroaryl, each of which is optionally substituted with one or more R3, and wherein the heteroaryl comprises up to 4 heteroatoms and one or two 5- or 6-membered ring(s);
R3 is independently selected from the group consisting of C1-6-alkyl, C1-6-alkyl-O—, halogen, HO—, and NC—; and
Y is selected from the group consisting of a bond, —CH2—, —CH2CH2—, and —CH2O—.

US Pat. No. 10,166,213

DERIVATIVES OF KORORMICIN USEFUL AS ANTIBIOTICS

8. A method of treating a bacterial disease comprising administering an effective amount of the compound of claim 1 to a subject in need thereof, wherein the bacterial disease is caused by a gram-negative bacteria.

US Pat. No. 10,166,212

ORAL USE OF ZINC AND COPPER GLUCONATES IN THE TREATMENT OF DIGITAL DERMATITIS

Dantrace-Danfeed IVS, Ta...

1. A method of treating and preventing digital dermatitis in a claw-bearing animal, comprising supplying zinc gluconate and copper gluconate for oral use in to the feed of said animal in an effective amount of zinc and copper, feeding said animal with said feed for a time period of at least 3 weeks, and concomitantly treating any diagnosed digital dermatitis lesion in said animal with a standard care topical treatment until said lesion is healed, wherein said zinc gluconate is administered in an amount of between 35 to 500 mg zinc per kg dry feed and said copper gluconate is administered in an amount of between 5 and 40 mg copper per kg dry feed.