US Pat. No. 10,137,287

DRUG DELIVERY DEVICES AND METHODS FOR CONTROLLED DRUG RELEASE THROUGH DEVICE ORIFICE

TARIS Biomedical LLC, Le...

1. An intravesical drug delivery device comprising:a device body comprising an elongated drug reservoir lumen and a retention frame lumen;
a drug positioned in the drug reservoir lumen;
a retention frame which comprises an elastic wire; and
at least one end plug positioned at an end of the device body comprises an aperture through which the drug is released from the drug reservoir lumen,
wherein the aperture has an initial diameter which is configured to release the drug in vivo predominately driven by osmosis, and, after a period within the bladder, the aperture has a second diameter which is greater than the initial diameter and with which release of the drug in vivo is predominately driven by diffusion.

US Pat. No. 10,137,286

APPARATUS FOR BENDING MALLEABLE GUIDE OF SURGICAL INSTRUMENT

Acclarent, Inc., Irvine,...

1. An apparatus comprising:(a) a grounding member, wherein the grounding member comprises:
(i) a first grounding feature, wherein the first grounding feature is configured to engage a dilation instrument,
(ii) a bending channel, wherein the bending channel is configured to receive a malleable member of the dilation instrument, and
(iii) a fixed indicator; and
(b) an actuator, wherein the actuator is pivotably coupled with the grounding member, wherein the actuator is configured to pivot between a first angular position and a second angular position, wherein the actuator comprises:
(i) a bearing surface, wherein the bearing surface is configured to cooperate with the bending channel to thereby bend the malleable member of the dilation instrument as the actuator is pivoted relative to the grounding member, and
(ii) a first movable indicator configured to align with the fixed indicator at the first angular position, and
(iii) a second moveable indicator spaced away from the first movable indicator an angular distance such that the second movable indicator is configured to align with the fixed indicator at the second angular position.

US Pat. No. 10,137,285

BALLOON DILATION SYSTEM WITH MALLEABLE INTERNAL GUIDE

Acclarent, Inc., Irvine,...

1. An apparatus comprising:(a) a handle assembly;
(b) a guide assembly extending distally from the handle assembly, wherein the guide assembly comprises:
(i) a malleable guide member having a distal end, wherein the malleable guide member is configured to assume and maintain a bent shape relative to a longitudinal axis of the guide assembly, and
(ii) a flexible guide member having a distal end, wherein the distal end of the flexible guide member is distal to the distal end of the malleable guide member, wherein the flexible guide member is slidably disposed positioned about the malleable guide member, wherein an entirety of the flexible guide member is translatable relative to the malleable guide member to advance the distal end of the flexible guide member relative to the distal end of the malleable guide member, wherein a portion of the flexible guide member is slidable along the malleable guide member; and
(c) a dilation catheter, wherein the dilation catheter is slidably disposed about the flexible guide member, wherein the flexible guide member and the dilation catheter are slidable independently of one another relative to the malleable guide member via the handle assembly.

US Pat. No. 10,137,284

PLEURAL SPACE DRAINING ASSEMBLY

1. A pleural space draining assembly comprising:a catheter;
a plurality of walls coupled to and positioned in said catheter defining a first channel, a second channel, and a third channel within said catheter;
a first port positioned through said catheter proximate to a first end of said catheter, said first port being fluidically coupled to said first channel;
a stylet having a tip, said tip being blunt, said stylet being complementary to said first channel;
a second port positioned through said catheter between said first port and a midpoint of said catheter, said second port being fluidically coupled to said second channel;
a balloon sealably positioned in said second channel, said balloon having an open end protruding from said first end of said catheter, said balloon being configured for reversible and selective inflation;
a plurality of holes positioned through said catheter, said holes being fluidically coupled to said third channel;
a valve fluidically coupled to said third channel at said first end of said catheter; and
wherein said first port is positioned in said catheter such that said first port is positioned for insertion of said stylet into said first channel, wherein said catheter is configured for insertion into a pleural space of a patient, wherein said balloon is positioned in said second channel such that said balloon is configured for inflation such that an inflated portion of said balloon protrudes from said catheter to fixedly position said catheter between a lung and an internal chest wall of the patient, wherein said holes are positioned in said catheter such that said holes are configured for gas and fluid to enter said third channel, and wherein said valve is positioned on said catheter such that said valve is configured for coupling to an accessory utilized in removing air and liquid from the pleural space through said third channel.

US Pat. No. 10,137,283

TEXTILE-REINFORCED HIGH-PRESSURE BALLOON

Cook Medical Technologies...

1. A textile-reinforced medical dilation balloon, comprising:a seamlessly woven tubular textile sleeve including substantially longitudinal warp threads that are substantially parallel to a central longitudinal axis of the sleeve and at least one weft thread having a high modulus, high tensile strength yarn, the at least one weft thread woven helically along a winding pitch that is substantially perpendicular relative to the warp threads without crossing over itself nor crossing over any other at least one weft thread between a proximal neck portion and a distal neck portion, wherein the sleeve defines a sleeve lumen; and
a medical dilation balloon disposed within the sleeve lumen.

US Pat. No. 10,137,282

STRETCH VALVE BALLOON CATHETER AND METHODS FOR PRODUCING AND USING SAME

Mayser, LLC, Fort Lauder...

1. A safety catheter, comprising:a flexible, multi-lumen shaft having an outer diameter, a distal tip, and a proximal catheter end with a drain end, the multi-lumen shaft defining:
a drain lumen extending through the shaft and shaped to drain fluid adjacent the distal tip proximally through the drain lumen and out the drain end;
a distal hollow balloon portion defining a balloon interior and having at least one inflation port fluidically connected to the balloon interior, the balloon portion inflating outwardly to a diameter greater than the outer diameter of the shaft when inflated with inflation fluid;
at least one inflation lumen parallel to the drain lumen and fluidically connected to the balloon interior through the at least one inflation port, the at least one inflation lumen shaped to inflate the balloon interior with the inflation fluid; and
a balloon drainage port fluidically connecting the balloon interior to the drain lumen; and
a stretch valve having:
a body removably disposed in the balloon drainage port and shaped to prevent fluid from passing through the balloon drainage port when disposed in the balloon drainage port; and
a connector:
fixedly attached to the body;
fixedly attached at a location adjacent the proximal catheter end; and
extending proximally from the body such that:
in a steady state, the stretch valve prevents the inflation fluid from passing through the balloon drainage port; and
in a stretched state when the proximal catheter end is stretched, the connector causes the body to remove from the balloon drainage port to permit the inflation fluid in the balloon interior to pass through the balloon drainage port and into the drain lumen.

US Pat. No. 10,137,281

CATHETER FOR TREATMENT OF SINUSITIS

Tsukada Medical Research ...

1. A catheter for treatment of sinusitis comprising:an anterior nasal aperture balloon;
an anterior nasal aperture balloon air supply lumen for inflating the anterior nasal aperture balloon;
a posterior nasal aperture balloon;
a posterior nasal aperture balloon air supply lumen for inflating the posterior nasal aperture balloon;
a drainage lumen having an opening between the anterior nasal aperture balloon and the posterior nasal aperture balloon;
a drainage catheter comprising the anterior nasal aperture balloon air supply lumen and the drainage lumen therein;
a posterior nasal aperture balloon catheter comprising the posterior nasal aperture balloon air supply lumen therein; and
an external air communication lumen having an opening on a distal side from the posterior nasal aperture balloon is further provided in the posterior nasal aperture balloon catheter,
wherein the catheter comprising the external air communication lumen is formed of silicone rubber,
wherein the drainage catheter and the posterior nasal aperture balloon catheter are arranged in a side-by-side configuration,
wherein a distance between the posterior nasal aperture balloon and the anterior nasal aperture balloon is adjustable, and
wherein adjustment of the distance between the posterior nasal aperture balloon and the anterior nasal aperture balloon is realized by an internal space having a circular section formed in the anterior nasal aperture balloon through which the posterior nasal aperture balloon catheter passes, and at least one annular sealing rib formed on a wall surface which surrounds the internal space, and the at least one annular sealing rib is configured to seal an annular gap between an outer surface of the posterior nasal aperture balloon catheter and the wall surface such that liquid does not pass through the annular gap between the outer surface and the wall surface.

US Pat. No. 10,137,279

CATHETER GUIDE AND METHOD FOR UTILIZING THE SAME

WILLIAM BEAUMONT HOSPITAL...

1. A catheter guide comprising:a first conduit for guiding a catheter, wherein the first conduit includes a tube-shaped body having a proximal end and a distal end, and wherein the distal end of the tube-shaped body is sized and configured to be inserted into a urethra;
a second conduit connected to an outer surface of the first conduit, wherein a passage extending through the first conduit is fluidly-connected to a passage extending through the second conduit;
a shield member, wherein the shield member includes an inner surface and an outer surface, wherein the shield member is connected to the outer surface of the first conduit, and wherein the distal end of the tube-shaped body of the first conduit extends through the shield member and beyond at least part of the inner surface of the shield member;
a grasping member that extends radially outwardly from and is integrally connected to the outer surface of the first conduit, wherein the grasping member is angularly offset from the second conduit at a first angle; and
a third conduit connected to the outer surface of the first conduit, wherein the passage extending through the first conduit is fluidly-connected to a passage extending through the third conduit, wherein the grasping member is angularly offset from the third conduit at a second angle, and wherein the second conduit is angularly offset from the third conduit at a third angle,
wherein the first conduit of the catheter guide includes one or more weakened zones, wherein at least one first weakened zone of the one or more weakened zones longitudinally extends along the length of the first conduit.

US Pat. No. 10,137,278

CANNULA STABILIZATION DEVICE

1. A cannula stabilization device comprising:a bearing platform;
a tubing holder located on a first end of the bearing platform;
a tubing holder located on a second end of the bearing platform opposite the first end, wherein each tubing holder is configured to secure and route continuous tubing, and wherein the tubing is configured to intersect the bearing platform only at each tubing holder;
a rotational joint fixedly attached to the bearing platform on a bottom side of the bearing platform; and
a helmet releasably attachable to the rotational joint;
wherein the helmet and the bearing platform are independently rotatable around a common rotational axis when the helmet is attached to the rotational joint.

US Pat. No. 10,137,277

CIRCADIAN-FRIENDLY LED LIGHT SOURCE

Soraa, Inc., Fremont, CA...

1. A light emitter comprising:one or more LEDs configured to emit LED light, said one or more LEDs comprising at least a violet pump LED configured to emit a pump light with a peak wavelength around 405 nm;
at least one phosphor configured to emit converted light by converting a fraction of said pump light; and
wherein said light emitter emits an emitted light formed by a combination of a fraction of said LED light and said converted light, said emitted light having a spectral power distribution (SPD), said SPD has a first power from 350 nm to 850 nm and a second power from 400 nm to about 440 nm, wherein said second power is at least 25% of said first power, and wherein said SPD has a CRI greater than 80 and an R9 greater than 0.

US Pat. No. 10,137,276

SYSTEM AND METHOD FOR SLEEP SESSION MANAGEMENT BASED ON SLOW WAVE SLEEP ACTIVITY IN A SUBJECT

Koninklijke Philips N.V.,...

1. A system configured to manage a sleep session of a subject, the system comprising:one or more sensory stimulators configured to provide sensory stimuli to the subject;
one or more sensors configured to generate output signals conveying information related to a current sleep stage of the subject during the sleep session; and
one or more processors configured by machine-readable instructions to:
determine a dissipation threshold level for triggering a sensory waking stimulus;
obtain, during the sleep session, the output signals from the one or more sensors, at least some of the output signals being related to slow wave activity in the subject;
monitor, during the sleep session, the slow wave activity based on the output signals;
determine, based on the monitoring of the slow wave activity, a rate of change in the slow wave activity over time with respect to the sleep session;
determine a sleep pressure dissipation level of the subject based on the rate of change in the slow wave activity, the sleep pressure dissipation level being a metric indicating a level of dissipation with respect to sleep pressure of the subject, the sleep pressure indicating the subject's remaining need for sleep; and
responsive to the sleep pressure dissipation level breaching the dissipation threshold level, control the one or more sensory stimulators to generate the sensory waking stimulus to cause the subject to wake from the sleep session.

US Pat. No. 10,137,275

OXYGEN CONCENTRATOR FOR HIGH PRESSURE OXYGEN DELIVERY WITH OXYGEN CIRCULATION LOOP AND IMPROVED PORTABILITY

BreatheTechnologies, Inc....

1. A portable apparatus for concentrating and delivering high pressure oxygen to a ventilator, the apparatus comprising:an enclosure defining an air inlet, an oxygen outlet and a flow pathway extending between the air inlet and the oxygen outlet;
a high pressure compressor disposed within the enclosure and integrated into the flow pathway, the high pressure compressor having a compressor inlet fluidly coupled to the air inlet, and a compressor outlet;
an adsorbent sieve bed disposed within the enclosure and integrated into the flow pathway, the sieve bed having a sieve bed inlet fluidly coupled to the compressor outlet of the high pressure compressor, and a sieve bed outlet, with the sieve bed being operative to remove nitrogen from air flowing therethrough;
a high pressure accumulator disposed within the enclosure and integrated into the flow pathway, the high pressure accumulator having an accumulator inlet fluidly coupled to the sieve bed outlet of the adsorbent sieve bed, and an accumulator outlet fluidly coupled to the oxygen outlet;
a first valve disposed within the enclosure and integrated into the flow pathway so as to be interposed between and fluidly coupled to both the sieve bed outlet of the sieve bed and the accumulator inlet of the accumulator, the first valve being operative to prevent flow from the high pressure accumulator to the sieve bed;
a third valve disposed within the enclosure and integrated into the flow pathway so as to be interposed between and fluidly coupled to both the air inlet and the compressor inlet of the high pressure compressor; and
an oxygen circulation loop having a first end fluidly coupled to the flow pathway between the third valve and the compressor inlet of the high pressure compressor, and a second end fluidly coupled to the flow pathway between the sieve bed outlet of the sieve bed and the first valve;
the oxygen circulation loop being operative to permit oxygen enriched gas to be circulated through the sieve bed, with the third valve being operative to prevent flow of the oxygen enriched gas to ambient via the air inlet;
the high pressure compressor, the sieve bed and the high pressure accumulator being sized and configured to allow the apparatus to operate at a pressure level in the range of from about 40-80 psi.

US Pat. No. 10,137,274

PATIENT INTERFACES

1. A patient interface comprising:a mask assembly configured to be coupled with an elbow assembly for delivering a pressurized gas to a patient;
the elbow assembly comprising:
a first leg configured to connect to a source of the pressurized gas at a first end of the elbow assembly; and
a second leg configured to swivelably connect to the mask assembly, the second leg comprising:
a second end of the elbow assembly configured to insertably interface with the mask assembly;
an outer conduit and an inner conduit fixed within the outer conduit, a first tubular section of the outer conduit disposed radially outward of a second tubular section of the inner conduit, the inner conduit and the outer conduit extending towards the second end of the elbow assembly from a front wall of the outer conduit, a distal end of the outer conduit disposed beyond a distal portion of the second tubular section of the inner conduit in an axial direction such that the distal portion of the second tubular section is disposed within a straight section of the second leg;
a first flow path defined between the inner conduit and the outer conduit, the first flow path accommodating a first flow of gases in a first direction;
a second flow path defined within the inner conduit, the second flow path accommodating a second flow of gases in a second direction, the first direction being directly opposite the second direction in at least a portion of the second leg; and
a diffuser comprising a plurality of exhaust vents in the front wall of the outer conduit.

US Pat. No. 10,137,273

PATIENT INTERFACES

1. A patient interface for use as part of a system for delivering a supply of gases to a patient comprising:a hollow body configured to be disposed on the patient's face in use and configured to deliver gases to the patient, said hollow body comprising an aperture extending from an inside of the hollow body to an outside of said hollow body; and
an elbow connector comprising a first end configured to be connected to a gas supply conduit, a second end configured to be swivelably connected to said aperture of said hollow body, and an exhaust port positioned between said first end and said second end, said exhaust port comprising a plurality of outlet vent holes extending through an outer wall of the elbow connector, and at least one wall at least partially defining an exhaust passage and extending from said exhaust port toward said second end, and said at least one wall being interposed between said exhaust passage and a delivery passage extending from said first end of said elbow connector to said second end of said elbow connector such that incoming gases are separated from said exhaust passage by said at least one wall, wherein said wall forms an enclosed perimeter such that a space within the wall is separated from a space that completely surrounds the wall, and wherein the wall extends in a direction aligned with the second end of the elbow connector;
wherein said at least one wall is rigid and fixed in position inside said elbow connector.

US Pat. No. 10,137,272

DEVICE FOR POSITIONING A PATIENT INTERFACE

Loweenstein Medical Techn...

1. An adjusting device for a patient interface that is fixed on the head of a patient by a head harness, wherein the device comprises at least one harness receiving element, a support body for supporting the patient interface in a region of the forehead of the patient and a single spring element which contacts the support body at least in a compressed state, wherein a tightening force of the head harness is transmitted to the spring element by the at least one harness receiving element such that the spring element is at least partially compressed to thereby exert a force which presses the support body against the forehead of the patient, and wherein the support body engages at least in part in a horizontal receiving element of a mask body and the spring element in a mounted state is present in part in the receiving element and in part in a guide to thereby be covered over its entire length.

US Pat. No. 10,137,271

NASAL INTERFACE

1. A nasal interface for use in a system for providing a flow of respiratory gases to a user, the nasal interface comprising:a body made from a pliable first material, the body comprising an inlet configured to receive a flow of gases and at least one nasal outlet, the at least one nasal outlet comprising a tubular structure configured to interface with a user's nostril, the at least one nasal outlet being fluidly connected to the inlet, wherein at least one plastically deformable member is attached to or integrally formed with the body, the at least one plastically deformable member having an elastic limit less than the elastic limit of the pliable first material; and
a flow restrictor comprising a member coupled to the body in a fixed position, the flow restrictor blocking a center of the flow of gases through the body and defining a gradually reducing cross sectional flow area such that all flow into and through the body passes through and is thereby restricted by the flow restrictor, wherein the flow restrictor is a dominant flow restriction of all gases flow in the system.

US Pat. No. 10,137,270

CUSHION TO FRAME ASSEMBLY MECHANISM

ResMed Limited, Bella Vi...

1. A mask assembly for treatment of sleep disorder breathing by delivering a flow of pressurized gas to a patient, the mask assembly comprising:a first frame including a first wall that at least partially delimits a breathing chamber, a second wall surrounding an opening through the first wall and defining a first substantially cylindrical surface surrounding the opening and defining a central axis, the second wall extending from the first wall, the opening being configured to allow the flow of pressurized gas to the breathing chamber;
a second frame including a third wall that is cylindrical and defines a second substantially cylindrical surface, a fourth wall, a member extending toward a forehead support and two headgear attachment locations, the third wall extending away from the fourth wall, the second substantially cylindrical surface at least partially overlapping with and passing completely around the first substantially cylindrical surface, and the second frame being configured to removably interlock with the first frame proximate the opening when the first frame and the second frame are moved towards one another along the central axis; and
a cushion molded to the first frame and including a side wall and a membrane adapted to seal around a patient's nose, the membrane being connected to the side wall at an outer periphery of the membrane and being unconnected at an inner periphery of the membrane; wherein
the membrane is on an opposite side of the first frame with respect to the opening,
the first frame comprises a first material and the cushion comprises a second material that is more flexible than the first material and the first wall and the second wall comprise the first material.

US Pat. No. 10,137,269

CUSHION-TO-FRAME COMPONENT FOR AN INTERFACING STRUCTURE

RESMED LIMITED, Bella Vi...

1. An interfacing structure for a mask system, comprising:a cushion component adapted to contact the patient's face in use; and
a cushion-to-frame component provided to the cushion component, the cushion-to-frame component structured to secure the cushion component to a mask frame of the mask system,
the cushion-to-frame component including a cushion side adapted to interface with the cushion component and a frame side adapted to interface with the mask frame,
wherein the cushion side includes a platform including an inner flange and an outer flange provided to opposing ends of the platform and an engagement surface between the inner flange and the outer flange to engage the cushion component, and
wherein the engagement surface is non-linear along its width and includes incline portions, decline portions, and flat portions along its width.

US Pat. No. 10,137,268

SYSTEM AND METHOD FOR SECURING A BREATHING GAS DELIVERY HOSE

CPAP Miracle LLC, Beachw...

1. A device comprising:a substantially rigid, elongated contiguous, tubular support member comprised of a tube wall having a first distal end, a second distal end, and a centralized living hinge biasing portion, integrated in the tube wall and comprised of a series of spaced apart slits in the tube wall, the living hinge, configured to bias arcuate movement between the first distal end and the second distal end, and wherein
the living hinge has an axial length smaller than axial lengths of the first and second distal ends,
a bias of the living hinge is configured to be adjustable while maintaining a fixed distance between the first and second distal ends, and
the bias of the living hinge corresponds to a position of an outer tube disposed circumferentially along a surface of the tube so as to be slide-able relative to the biasing portion;
a generally planar, rigid base configured to receive an associated pillow on an upper surface thereof so as to secure the first distal end so that the support member extends from a surface of the base to hold the first distal end in a generally vertical position relative to the second distal end when a radial force is applied to the second distal end during flexure of the living hinge;
a mount comprised of first and second coaxial, biased C-clips secured to the second distal end, the mount configured to snap fit an associated tube thereto with substantially unrestricted fluid flow therethrough; and
a mount support, formed from a cutaway portion of the tube wall, extending radially outwardly from the tube.

US Pat. No. 10,137,267

TRACHEOSTOMY TUBES

SMITHS MEDICAL INTERNATIO...

1. A tracheostomy tube having a shaft with a length, a patient end, a machine end and a fenestrated region locating substantially midway along the length and spaced from the machine end and the patient end including at least one opening at a location adapted to lie within the trachea, characterized in that the shaft is formed of a first material that is relatively soft and that the fenestrated region of the tube is formed only by a plate that includes the at least one opening, the plate formed of a second material that is stiffer than the first material to increase the overall stiffness of the shaft at the fenestrated region such that the portion of the shaft between the patient end of the tube and the patient end of the plate is more flexible than the fenestrated portion.

US Pat. No. 10,137,266

PATIENT-VENTILATOR DYSSYNCHRONY DETECTION

KONINKLIJKE PHILIPS N.V.,...

1. A method of detecting dyssynchrony between a patient and a pressure support system, comprising:receiving patient flow data representing a patient flow waveform, the patient flow waveform representing a flow of gas provided to the patient by the pressure support system;
obtaining an I/E state signal indicating whether a current respiratory phase of the patient is inspiratory or expiratory, the I/E state signal being in binary form and having only a first binary state and a second binary state, the first binary state indicating that the current respiratory phase is inspiratory and the second binary state indicating that the current respiratory phase is expiratory; and
analyzing both the patient flow data and the I/E state signal for a breath to determine whether at least one of a number of predetermined criterion is satisfied based on both the patient flow data and the I/E state signal and declaring a dyssynchrony for the breath and outputting a dyssynchrony indicator if it is determined that at least one of the number of predetermined criterion is satisfied based on both the patient flow data and the I/E state signal, wherein the dyssynchrony is a condition where a respiratory drive of the patient is out of sync with breaths being generated by the pressure support system, wherein the number of predetermined criterion includes all of; (i) a number of volume qualified flow slope reversals in the patient flow data for the breath exceeding a predetermined number; (ii) an incremented tidal volume during at least a portion of an expiratory phase of the breath as indicated by the I/E state signal exceeding a predetermined positive value; (iii) an absolute value of a tidal volume during the breath exceeds a predetermined value; and (iv) a tidal volume during an inspiratory phase of the breath as indicated by the I/E state is less than a predetermined negative value.

US Pat. No. 10,137,265

SYSTEMS AND METHODS FOR WIRELESS FEEDBACK DURING VENTILATION

ZOLL MEDICAL CORPORATION,...

1. A system for providing feedback on delivery of cardiopulmonary resuscitation (CPR), the system comprising:a manual patient ventilation unit defining an airflow path, the unit arranged so that when the unit is applied to a patient, the airflow path is in fluid communication with the patients airway, the patient ventilation unit comprising:
a ventilation bag configured to enable manual ventilation of the patient by a rescuer;
at least one first sensor in the airflow path positioned to sense the presence of ventilation airflow and measure a gas flow rate in the airflow path; and
at least one second sensor in the airflow path positioned to sense gas pressure in the airflow path;
at least one chest compression sensor configured to detect and measure compression information based on chest compressions applied to the patient; and
a feedback unit separate from the manual patient ventilation unit comprising a processor arranged to:
wirelessly receive data generated by the at least one first sensor and the at least one second sensor;
determine one or more ventilation quality parameters based at least in part on a gas flow volume calculated based on the sensed gas flow rate and gas pressures;
receive compression data generated by the at least one chest compression sensor;
determine one or more chest compression parameters based at least in part on the measured compression information; and
provide both ventilation feedback and chest compression feedback to a rescuer, the ventilation feedback comprising the one or more ventilation quality parameters and instructions for performing ventilations based upon a comparison of the ventilation quality parameters with a ventilation protocol comprising ranges of predetermined acceptable values for administering ventilations to the patient and the chest compression feedback comprising the one or more chest compression parameters and instructions for performing chest compressions based upon a comparison of the chest compression parameters with a chest compression protocol comprising ranges of predetermined acceptable values for administering chest compressions to the patient,
wherein the ventilation quality parameters comprise one or more of tidal volume, minute volume, end-inspiratory pressure, and maximum ventilation pressure.

US Pat. No. 10,137,264

RESPIRATORY ASSISTANCE APPARATUS

1. A head-mounted respiratory assistance apparatus configured to provide a respiratory gases stream to a user, comprising:a main body securable to the head of a user;
a blower unit provided on the main body having a gases inlet to receive a supply of gases from the surrounding atmosphere and which is operable to generate a pressurised gases stream at a gases outlet, wherein the blower unit comprises a casing and wherein the gases outlet extends radially outward from a center of the casing; and
a patient interface provided on the main body having a gases inlet which is fluidly connected via a gases flow path to the gases outlet of the blower unit and which is configured to deliver the pressurised gases to the user's nose and/or mouth via one or more gases outlets,
wherein the gases flow path from the gases inlet of the blower unit to the gases outlet(s) of the patient interface is substantially sealed such that there is zero bias flow along the gases flow path, and
wherein the blower unit comprises a lightweight shroudless impeller, wherein the impeller comprises a plurality of separated impeller blades extending outward from a central hub of the impeller, and a motor with a rotatable drive shaft that is configured to rotate the impeller.

US Pat. No. 10,137,263

APPARATUS AND METHOD FOR MONITORING AN AIRWAY DEVICE SUCH AS AN ENDOTRACHEAL TUBE

Indian Ocean Medical Inc....

1. A method of detecting a leak of fluid from an inflatable airway device in a closed volume pressure system, the method comprising:periodically receiving a pressure value for the inflatable airway device from a pressure sensor in a pressure control and monitoring apparatus in the closed volume pressure system;
in a processor of the pressure control and monitoring apparatus, comparing the received pressure value with a setpoint value to determine a difference between the received pressure value and the setpoint value;
calculating in the processor if the difference is within a predefined tolerance band of the setpoint value;
calculating in the processor a rate of change of volume as a number of steps of a stepper motor in the closed volume pressure system required to correct the difference between the received pressure value and the setpoint value;
if the received pressure value is higher than the predefined tolerance band, setting the number of steps of the stepper motor as negative, if the received pressure value is lower than the predefined tolerance band, setting the number of steps of the stepper motor as positive, and driving the stepper motor the number of steps required to correct the difference between the received pressure value and the setpoint value;
calculating in the processor a statistical average of the rate of change of volume calculated using the received pressure value and a predetermined number of previously received pressure values to indicate whether significant changes have been necessary over a preceding time interval to increase pressure to the setpoint value;
determining if the statistical average is greater or lower than a threshold value, wherein the threshold value is a minimum average value that is indicative of an ineffective operation of pressure regulation in response to pressure reduction arising during normal usage of a patient and the minimum average value represents an average value for a breathing cycle, including inflation, deflation, and static steps, over a predetermined number of seconds; and
if the statistical average is greater than the threshold value, activating an alarm in the pressure control and monitoring apparatus to indicate a leak of fluid from the airway device.

US Pat. No. 10,137,262

SYNCHRONIZING MECHANICAL IN-EXSUFFLATION AND DIAPHRAGMATIC PACING

KONINKLIJKE PHILIPS N.V.,...

1. A system for synchronizing machine-induced inexsufflation with a diaphragmatic pacing of a subject, the system comprising;a pressure generator configured to generate a pressurized flow of breathable gas for delivery to an airway of the subject;
one or more sensors configured to generate one or more output signals conveying information related to one or both of
i) one or more gas parameters of a flow of breathable gas being breathed by the subject and/or
ii) one or more respiratory parameters of the subject; and
one or more processors configured to execute computer program modules, the computer program modules comprising:
a configuration module configured to obtain one or more configurable operational settings of the diaphragmatic pacing of the subject;
a detection module configured to detect onsets of inhalations of the subject such that, for a first respiratory cycle, the detection module detects an onset of a first inhalation of the subject based on the one or more output signals, wherein the first inhalation is included in the first respiratory cycle;
a target module configured to determine a target parameter for machine-induced inexsufflation during respiratory cycles such that, responsive to detection of the onset of the first inhalation, the target module determines the target parameter for machine-induced inexsufflation during a second respiratory cycle such that the machine-induced inexsufflation occurs in synchrony with the diaphragmatic pacing of the subject, wherein the second respiratory cycle is subsequent to the first respiratory cycle, and wherein the target parameter corresponds to an onset of inhalation during the second respiratory cycle or an onset of exhalation during the second respiratory cycle; and
a control module configured to control the pressure generator to inexsufflate the subject such that during the second respiratory cycle the control module controls the pressure generator to inexsufflate the subject in accordance with the target parameter for machine-induced inexsufflation, wherein:
inexsufflating the subject comprises controlling the pressure generator to generate a pressure cycle providing a positive pressure during a first time period, a negative pressure during a second time period, and a pause in pressure generation during a third time period, wherein the third time period occurs subsequent to the second time period and the second time period occurs subsequent to the first time period; and
at least two of the first, second, or third time periods are adjusted based on the target parameter in one or more subsequent pressure cycles to enhance synchronization of the machine-induced inexsufflation with the diaphragmatic pacing over multiple pressure or respiratory cycles.

US Pat. No. 10,137,261

INHALATOR

LK INVESTMENT APS, Humle...

1. An inhalator comprising a housing with at least a first compartment and a second compartment, and including one or more substances, and a release device, said second compartment including at least one air entry port, said inhalator having a first proximal end of said first compartment and a second proximal end of said second compartment and a first distal end of the first compartment, a second distal end distal of the second compartment, the at least one entry port is at the second distal end, an inhalation part being at said second proximal end, said first compartment being for storing at least one substance and including in an inoperative state of said inhalator a plurality of sealing bodies arranged in a neighboring relationship, without the release device inserted into the housing, wherein being proximal is closest to a mouth of a user and being distal is furthest away from the mouth of said user;wherein at least one pair of neighboring sealing bodies defines at least in part a sealed chamber for containing a substance, said at least one pair of neighboring sealing bodies being movable together with said at least one substance from said first compartment into said second compartment to define an operative state of said inhalator;
said operative state of the inhalator being a state;
wherein said one or more substances are contained and are allowed to mix and blend in said second compartment;
the release device is in the first compartment, and
air entering through said at least one air entry port obtains at least a part of said at least one substance contained in said second compartment and is inhaled through said inhalation part while the release device is in the first compartment; and
wherein said release device is for moving at least one of the sealing bodies from the first compartment to the second compartment when being inserted into the first compartment from the first distal end, and is configured to allow said air to flow to said at least one air entry port in the operative state, and the second compartment is located between the inhalation part and the first compartment.

US Pat. No. 10,137,260

NEBULIZER KIT AND NEBULIZER

OMRON HEALTHCARE CO., LTD...

1. A nebulizer kit comprising:an external air introduction tube defining an external air introduction path that introduces external air into the nebulizer kit;
an atomization portion that generates aerosol using compressed air from a compressed air tube unit, the atomization portion including a conically shaped liquid aspiration tube forming body that has an opening formed at both ends thereof, the atomization portion being provided at a center position within the external air introduction tube such that the external air introduction tube surrounds at least an upper portion of the atomization portion; and
a case body surrounding the external air introduction tube and defining an aerosol carrier path that communicates with an aerosol discharge port, the aerosol carrier path having at least a first region and a second region, the first region being located closer to the aerosol discharge port, and the second region being located opposite to the first region, wherein:
the case body includes an aerosol stream changing portion being provided in the second region of the aerosol carrier path, the atomization portion being located between the first region and the second region;
the aerosol changing portion is configured to redirect a stream of the aerosol flowing in a direction away from the aerosol discharge port to a direction toward the aerosol discharge port;
the case body is semicircular in shape and has a first curved wall surface that surrounds a portion of the external air introduction tube, the first wall surface is provided with the aerosol discharge port, and a second wall surface opposite to the first wall surface;
the second wall surface is a flat planar surface;
a distance from the second wall surface to the atomization portion along a horizontal plane passing through the atomization portion being smaller than a distance from the first wall surface to the atomization portion along the same horizontal plane;
the second wall surface is the aerosol stream changing portion;
the first region of the aerosol carrier path extends vertically through the case body;
the aerosol discharge port is directly disposed vertically above a reservoir that surrounds the external air introduction tube; and
the compressed air tube unit being off center from a vertical axis of the case body.

US Pat. No. 10,137,259

PORTABLE ULTRASONIC NEBULIZER AND NEBULIZATION STRUCTURE THEREOF

HCMED INNOVATIONS CO., LT...

1. A nebulization structure, comprising:a carrier unit having a first carrier portion, a first surrounding portion extended outward from an outer perimeter of the first carrier portion, a second carrier portion extended outward from an outer perimeter of the first surrounding portion, and a second surrounding portion extended outward from an outer perimeter of the second carrier portion, wherein the first carrier portion has a through hole, and the first surrounding portion, the second carrier portion and the second surrounding portion are sequentially connected to form a surrounding groove, wherein the first surrounding portion is extended backward and slantwise from the outer perimeter of the first carrier portion;
a vibration unit including an annular vibrating sheet received in the surrounding groove;
a waterproof package unit received in the surrounding groove to enclose the annular vibrating sheet;
a nebulization unit disposed on the first carrier portion, wherein the nebulization unit has a plurality of micro holes communicated with the through hole; and
a position-limiting unit having a first position-limiting portion disposed on the nebulization unit and a second position-limiting portion extended outward and slantwise from an outer perimeter of the first position-limiting portion and along the first surrounding portion, wherein the nebulization unit is positioned between the first carrier portion and the position-limiting unit, and the first position-limiting portion has an opening for exposing the micro holes.

US Pat. No. 10,137,257

SLACK-TIME HEATING SYSTEM FOR BLOOD AND FLUID WARMING

Belmont Instrument, LLC, ...

1. A system for heating an infusate, the system comprising:a reservoir for containing an infusate;
an induction fluid heater comprising a circular single flow path therewithin;
a diversion valve;
a patient line; and
a recirculation line,
wherein the induction fluid heater comprises an inlet to receive the infusate from the reservoir and to direct the infusate to the circular single flow path,
wherein the induction fluid heater comprises an outlet to direct a heated infusate from the circular single flow path into the patient line and/or the recirculation line,
wherein the diversion valve operates to direct the heated infusate from the induction fluid heater into the patient line and/or the recirculation line, said diversion valve controlling a ratio of a flow in the patient line to a flow in the recirculation line,
wherein the patient line directs the heated infusate to a patient, and
wherein the recirculation line directs the heated infusate to the reservoir, so that the system increases a temperature of the infusate in the reservoir.

US Pat. No. 10,137,256

AUTOINJECTOR

Sanofi-Aventis Deutschlan...

1. An autoinjector comprising:a case adapted to hold a medicament container having a needle;
a needle shroud telescopically coupled to the case and movable between a first extended position relative to the case in which the needle is covered, a retracted position relative to the case in which the needle is exposed, and a second extended position relative to the case in which the needle is covered and the needle shroud is inhibited from translating relative to the case; and
a plunger slidably disposed in the case and movable between a proximal position, an intermediate position and a distal position relative to the case,
wherein, when the plunger is in the intermediate position and the needle shroud is in the retracted position, the plunger abuts the case to prevent the needle shroud from returning to the first extended position, and
wherein, when the plunger is in the distal position and the needle shroud is in the second extended position, the plunger abuts the case to prevent the needle shroud from returning to the retracted position.

US Pat. No. 10,137,255

AUTOINJECTOR

Sanofi-Aventis Deutschlan...

1. An autoinjector comprising:a case having a rib;
a needle shroud telescopically coupled to the case and movable between a first extended position, a retracted position and a locked second extended position;
a carrier slidably arranged in the case and adapted to hold a medicament container, the carrier movable from a first axial position to a second axial position relative to the case;
a collar rotatably and slidably disposed in the case, the collar coupled to the needle shroud and the carrier; and
a control spring biasing the collar in a distal direction relative to the case,
wherein the collar is adapted to abut the rib when the needle shroud is in the first extended position and the carrier is in the first axial position, and the collar is adapted to disengage the rib when the needle shroud is in the retracted position and the carrier is in the second axial position,
wherein the collar includes a shroud boss adapted to engage a shroud slot in the needle shroud, a carrier boss adapted to engage a carrier slot in the carrier, and a case boss adapted to engage the rib in the case,
wherein the collar is adapted to couple a force of the control spring to one of the carrier, the needle shroud and the case based on axial and rotational positions of the needle shroud, the carrier, and the rib in the case relative to the collar.

US Pat. No. 10,137,254

TELESCOPIC DRIVE ARRANGEMENT FOR DRUG DELIVERY DEVICE

1. A drug delivery device, comprising:a compartment adapted to receive and hold a drug-filled cartridge having an axially moveable piston,
a support structure,
a drive tube comprising an inner thread,
a motor assembly having a distal portion and a proximal portion, the distal portion comprising a rotatable drive shaft and being adapted to be received inside the drive tube,
a drive member comprising an outer thread, and
a controller for controlling the motor assembly,wherein:the drive member outer thread is in threaded engagement with the drive tube inner thread,
the motor assembly is arranged non-rotational relative to the support structure,
the drive tube is arranged axially displaceable but non-rotational relative to the motor assembly and is adapted to engage and axially move, directly or indirectly, the piston of a loaded cartridge to thereby expel drug from the cartridge,
the motor assembly proximal portion is connected to the support structure via a first flexible joint, and
the drive shaft is connected to the drive member via a second flexible joint,whereby rotation of the drive shaft results in axial, non-rotational displacement of the drive tube relative to the support structure.

US Pat. No. 10,137,252

PEN-SHAPED TORSION SPRING DRIVEN INJECTION DEVICE

1. A pen-shaped torsion spring driven injection device for apportioning set dose of a liquid drug comprising:A housing having a window,
A piston rod having an external thread,
A rotatable piston rod guide engaging and driving the piston rod during dose expelling,
A torsion spring for rotating the piston rod guide,
A rotatable scale drum having a thread engaging the external thread of the piston rod and carrying a plurality of indicia viewable through the window of the housing,
A rotatable dose setting member cooperating with the scale drum such that rotation of the dose setting member during dose setting is transformed to a rotation of the scale drum, and whereinthe piston rod is held inrotatable during dose setting whereby the scale drum rotates helically on the external thread of the piston rod.

US Pat. No. 10,137,251

ASSEMBLY FOR A DRUG DELIVERY DEVICE AND DRUG DELIVERY DEVICE

Sanofi-Aventis Deutschlan...

1. An assembly for a drug delivery device, comprising:a compression spring, wherein the compression spring is compressed during a setting of a dose of a drug;
a sleeve member,
a rotation member, wherein the sleeve member is rotationally fixed and axially moveable with respect to the rotation member;
a dose setting member which is configured to be rotated in a dose setting direction in order to set a dose, wherein a rotation of the dose setting member in the dose setting direction causes a rotation of the rotation member in the dose setting direction, wherein the rotation member is coupled to the dose setting member by means of a drive shaft;
an actuator which is configured to be operated in order to dispense the dose of the drug, wherein the compression spring is enabled to relax when the actuator is operated; and
a locking member which is configured to inhibit a rotation of the rotation member in a dose dispensing direction during the setting of the dose, thereby inhibiting a relaxation of the compression spring,
wherein the compression spring abuts the sleeve member and wherein the compression spring and the sleeve member are configured such that the relaxation of the compression spring effects a rotational movement and an axial movement of the sleeve member in a proximal direction away from a dispensing end of the drug delivery device, thereby causing a dispensing of the dose from the drug delivery device, and wherein the assembly further comprises a housing, wherein the compression spring is arranged between a bearing surface of the housing and the sleeve member, and wherein the compression spring exerts a force on the sleeve member which is directed in the proximal direction.

US Pat. No. 10,137,250

SYRINGE AND PREFILLED SYRINGE

TERUMO KABUSHIKI KAISHA, ...

1. A syringe comprising:a cylindrically-shaped gasket comprising a closed distal end, an open proximal end, and an inner cavity portion extending distally from a proximal side;
a barrel comprising a distal opening portion and configured to slidably contain the gasket; and
a plunger comprising a head portion configured to be contained in the inner cavity portion of the gasket,
wherein the head portion comprises:
a shaft portion, and
a helical rib located at an outer surface of the shaft portion, the helical rib comprising a starting end on a distal side and a terminal end on a proximal side,
wherein the gasket comprises, on an inner surface of the inner cavity portion, a helical crest portion forming a helical valley portion configured to threadedly engage with the helical rib of the plunger, and a plunger-retaining annular rib positioned distally from the helical crest portion, wherein the inner cavity portion further comprises an accommodation portion positioned distally from the plunger-retaining annular rib, the accommodation portion configured to contain a part of the head portion of the plunger at which the helical rib is formed, and wherein the plunger-retaining annular rib further comprises a rib absent portion configured to guide, to the accommodation portion, the helical rib reaching the plunger-retaining annular rib as threaded engagement is advanced between the plunger and the gasket,
wherein the plunger comprises, at the terminal end of the helical rib, an entrance-restricting terminal end portion configured to restrict the entrance of the helical rib into the rib absent portion after the part of the plunger at which the helical rib is formed is contained in the accommodation portion of the gasket,
wherein the helical rib includes a proximal surface extending outward from the shaft portion, a distal surface extending outward from the shaft portion, and an outer surface extending between the proximal surface to the distal surface, and
wherein the entrance-restricting terminal end portion comprises a terminal end surface that extends (i) between the proximal surface of the helical rib and the distal surface of the helical rib, and (ii) between the shaft portion and the outer surface of the helical rib.

US Pat. No. 10,137,249

PRIMING CONFIGURATION FOR A MEDICAL DEVICE AND DRUG DELIVERY DEVICE COMPRISING A PRIMING CONFIGURATION

Sanofi, Paris (FR)

1. A priming configuration for a medical device, the priming configuration comprising:a piston rod configured to operate the device; and
a movable element comprising an inclined surface being arranged to engage the piston rod, wherein the inclined surface is arranged to be movable in a transverse direction with respect to the piston rod by a user of the medical device, wherein the inclined surface slides along the piston rod during a movement of the inclined surface in the transverse direction, and wherein the movement of the inclined surface in the transverse direction from one end of the inclined surface to an opposite end of the inclined surface causes the engagement of the inclined surface and the piston rod to advance the piston rod in a further direction different from the transverse direction thereby providing a priming of the medical device before use.

US Pat. No. 10,137,248

AUTO-INJECTION DEVICE

SHL Group AB, Nacka Stra...

1. A medical delivery device comprising:a housing; and
a syringe holder having a syringe holder wall comprising a substantially tubular shape, the syringe holder wall being parallel to a longitudinal axis of the medical delivery device, the syringe holder wall comprising:
an open proximal end,
a slot extending from the open proximal end, resulting in a C-shaped cross sectional shape of the syringe holder wall in the proximal end,
wherein the open proximal end comprises a C-shaped proximal supporting collar arranged around an inner periphery of the syringe holder wall, wherein the C-shaped proximal supporting collar is configured such that, when a syringe having an outer diameter that is greater than an inner diameter of the C-shaped proximal supporting collar is longitudinally inserted into the syringe holder, the C-shaped proximal supporting collar flexes radially outward from a first position to a second position for allowing a tubular needle shield of the syringe to pass until a neck of the syringe is supported by the C-shaped proximal supporting collar, and
an open distal end comprising a distal supporting collar, wherein the distal supporting collar is arranged around and in contact with an outer periphery of the syringe holder wall, and wherein the distal supporting collar comprises a surface that is perpendicular to the longitudinal axis and configured to abut a proximal side of a radially extending flange of the syringe after the syringe is inserted into the syringe holder,
wherein the syringe holder is movably arranged in the housing between a distal position in which the syringe can be longitudinally inserted into the syringe holder and a proximal assembled position,
wherein an outer periphery of the proximal end of the syringe holder is configured to be radially supported by at least one contact surface on an inside surface of the housing when the syringe holder is in the proximal assembled position, and
wherein the at least one contact surface is configured to prevent the C-shaped proximal supporting collar from flexing radially outward to the second position when the syringe holder is in the proximal assembled position, thereby restraining the syringe within the syringe holder.

US Pat. No. 10,137,247

APPARATUS AND METHODS FOR DELIVERY OF THERAPEUTIC AGENTS TO MUCOUS OR SEROUS MEMBRANE

1. A method, comprising:receiving from a sensor at least one body signal from a patient;
detecting a condition of said patient based on said body signal, said detecting a condition being detected by a therapy device; and
administering a therapy with said therapy device to at least one of a mucous membrane or a serous membrane of said patient, in response to said detecting; wherein said body signal is a signal indicative of a concentration of a therapeutic medication in a body fluid; said condition is said concentration of said therapeutic medication being above a second concentration; and said therapy comprises at least one of reducing a dose of said therapeutic medication, reducing a rate of delivery of said therapeutic medication, or delaying a delivery of said therapeutic medication.

US Pat. No. 10,137,246

INFUSION PUMP ASSEMBLY AND METHOD

Bigfoot Biomedical, Inc.,...

1. A medical infusion pump system, comprising: a portable pump housing configured to receive insulin for dispensation to a user, the pump housing at least partially containing a pump drive system to dispense the insulin through a flow path to the user; a controller communicatively coupled with the pump drive system to cause dispensation of the insulin from the portable pump housing, the controller having computer memory for storing instructions, and one or more processors for executing the instructions stored in the computer memory; a first wireless communication device configured to receive a suggested bolus dosage amount from a mobile device, wherein the suggested bolus dosage amount has been calculated by a dosage calculator executing on the mobile device, the dosage calculator using at least one recent blood glucose measurement of the user to calculate the suggested bolus dosage amount; and a near field communication (NFC) circuit configured to receive NFC communications from the mobile device; wherein, the instructions stored in the computer memory, when executed by the one or more processors of the controller, cause the controller to perform operations comprising: in response to receiving the suggested bolus dosage amount from the mobile device, prompting the user for confirmation of acceptance of the suggested bolus dosage; receiving an NFC communication, via the NFC circuit, indicating confirmation of acceptance of the suggested bolus dosage; and in response to receiving the NFC communication indicating confirmation of acceptance of the suggested bolus dosage, controlling the pump drive system to cause dispensation of the suggested bolus dosage.

US Pat. No. 10,137,245

CENTRAL SITE PHOTOPLETHYSMOGRAPHY, MEDICATION ADMINISTRATION, AND SAFETY

University of Florida Res...

1. A system for monitoring and control for safe administration, reduction or cessation of administration of at least one of medication to a subject, comprising:(a) at least one photoplethysmography (PPG) sensor adapted to secure to a central source site of the subject;
(b) an infusion pump for delivering the at least one medication to the subject, wherein the infusion pump comprises an infusion controller for increasing or decreasing flow of medication to the subject; and
(c) an infusion pump agnostic safety device that is adapted to be deployed onto tubing adapted to deliver the at least one medication from the infusion pump to the subject, wherein the safety device comprises an occlusion apparatus and an occlusion controller, wherein the occlusion controller receives signals from the PPG sensor, calculates at least one respiratory parameter based on the signals from the PPG sensor, and if the at least one respiratory parameter is determined by the occlusion controller to be adverse, the occlusion controller directs the occlusion apparatus to partially or completely occlude the tubing
wherein the infusion pump agnostic safety device only occludes the tubing in the event the occlusion controller determines that an adverse event has occurred.

US Pat. No. 10,137,244

MICROFLUIDIC DRUG DELIVERY DEVICES WITH VENTURI EFFECT

ALCYONE LIFESCIENCES, INC...

1. A microfluidic convection-enhanced-delivery (CED) device, comprising:a shank portion;
at least one fluid delivery conduit having a proximal end, a distal end, a fluid inlet port, and at least one fluid outlet port, the at least one fluid delivery conduit being formed in or on the shank portion, the at least one fluid delivery conduit comprising first and second upstream lumens and a single downstream lumen;
a flow restriction formed within the at least one fluid delivery conduit at a merge of the first and second upstream lumens into the single downstream lumen, the flow restriction being configured to adjust a pressure of fluid being directed through the at least one fluid delivery conduit;
wherein the flow restriction comprises a constricted region of the at least one fluid delivery conduit having a cross-sectional area that is less than a cross-sectional area of a proximally-adjacent portion of the at least one fluid delivery conduit;
wherein the at least one fluid outlet port includes a plurality of fluid outlet ports formed in the first and second upstream lumens and a plurality of fluid outlet ports formed in the single downstream lumen; and
wherein the plurality of fluid outlet ports formed in the first and second upstream lumens are formed in an outermost surface of the microfluidic CED device and disposed such that fluid exits from the first and second upstream lumens directly to a location exterior to the microfluidic CED device.

US Pat. No. 10,137,243

INFUSION DEVICES WITH DISTRIBUTED MOTOR CONTROL AND RELATED OPERATING METHODS

Medtronic MiniMed, Inc., ...

1. An infusion device comprising:a motor operable to deliver fluid to a body of a user;
a driver module coupled to the motor;
a first switching arrangement coupled between the driver module and an energy source;
a second switching arrangement coupled between the driver module and the motor;
a first control module coupled to the first switching arrangement; and
a second control module coupled to the first control module, the driver module, and the second switching arrangement, the first control module operating the first switching arrangement to provide a path for input power from the energy source to the driver module in accordance with a handshaking sequence of communications between the first control module and the second control module and providing a dosage command to the second control module, the second control module operating the second switching arrangement to provide a path for output power from the driver module to the motor in accordance with the handshaking sequence of communications and operating the driver module to deliver the output power comprising a portion of the input power to the motor based at least in part on the dosage command.

US Pat. No. 10,137,242

FLUID DISPENSING DEVICE WITH A FLOW DETECTOR

Roche Diabetes Care, Inc....

1. A portable therapeutic fluid delivery device for delivering a therapeutic fluid into a body of a patient, the fluid delivery device comprising:a first part comprising,
a driving mechanism,
a flow detector comprising at least one heating element and at least two temperature sensors, and
a processor;
a second part comprising,
a reservoir,
an exit port, and
a delivery tube communicating between the reservoir and the exit port;
wherein the first part and the second part are designed such that upon pairing of the first part with the second part, the at least one heating element and the at least two temperature sensors touch the delivery tube, and wherein the processor, upon activation of the at least one heating element, determines a flow condition of the therapeutic fluid inside the delivery tube based on signals provided by the at least two temperature sensors.

US Pat. No. 10,137,241

AUTOMATED INSERTION ASSEMBLY

DEKA PRODUCTS LIMITED PAR...

1. An automated insertion system comprising:a cartridge assembly comprising:
a toothed track;
a toothless groove; and
at least one dermal perforation assembly having an interior passage configured to releasably engage at least a portion of a subdermal device therein; and
an actuation assembly configured to drive the at least one dermal perforation assembly a predetermined distance, the actuation assembly comprising:
a drive gear set comprising an uppermost gear, the drive gear set for engaging the cartridge assembly;
an actuator; and
a torsion spring,
wherein when the uppermost gear of the drive gear set is engaged with the toothed track of the cartridge assembly, the actuator is raised and the torsion spring is wound,
wherein after the at least one dermal perforation assembly is driven the predetermined distance, the uppermost gear of the drive gear set is seated in the toothless groove.

US Pat. No. 10,137,240

CAPILLARY CHANNEL STRUCTURE FOR DISPENSE INTERFACE

Sanofi-Aventis Deutschlan...

1. A dispense interface for a drug delivery device for delivering at least two drug agents, comprising:at least two flow regulation structures configured to connect to at least two fluid reservoirs; and
a confluence at which the at least two flow regulation structures meet,
wherein each flow regulation structure has a first end and a second end and comprises:
a fluid inlet opening at the first end, the fluid inlet opening of each flow regulation structure configured to connect to a different one of the at least two fluid reservoirs, and
a fluid outlet opening at the second end connected to the confluence,
wherein one or more of the at least two flow regulation structures each further comprises a capillary fluid channel that ends at the confluence,
each capillary fluid channel having a volume configured to contain a backflow from one or more others of the at least two flow regulation structures, and arranged in a meandering pattern on a plane perpendicular to a direction of fluid flow through an outlet of the confluence.

US Pat. No. 10,137,239

SYSTEMS AND METHODS FOR MONITORING TIME BASED PHOTO ACTIVE AGENT DELIVERY OR PHOTO ACTIVE MARKER PRESENCE

Avedro, Inc., Waltham, M...

1. A system for monitoring treatment of corneal tissue, comprising:an excitation source that directs light to the corneal tissue treated with a cross-linking agent, the light causing the cross-linking agent to fluoresce;
an image capture system that captures one or more images of the corneal tissue in response to the excitation source directing the light to the corneal tissue, the one or more images showing the fluorescing cross-linking agent; and
a controller that is configured to receive the one or more images of the corneal tissue and to provide information relating to cross-linking activity with the cross-linking agent in the corneal tissue based on one or more wavelengths emitted by the fluorescing cross-linking agent,
wherein the excitation source directs the light to the corneal tissue along an axis; the image capture system includes a camera and a lens; the camera captures the one or more images of the corneal tissue via the lens; the camera and the lens are offset from the axis defined by the light; the camera defines an image plane; the lens defines a lens plane; the lens plane is separate from the image plane; the one or more images of the corneal tissue are associated with a focal plane defined by the camera and the lens; and the camera and the lens are oriented such that the image plane, the lens plane, and the focal plane all intersect each other at a common intersection.

US Pat. No. 10,137,238

METHOD OF STORING BOTH NEW AND USED PEN NEEDLES

Becton, Dickinson and Com...

1. A method for storing both new and used pen needles of an injection apparatus in a single storage assembly, comprising the steps of:removing a cover to access a new pen needle secured within an opening of said assembly;
attaching said new pen needle to a drug delivery pen, wherein said new pen needle is releasably secured within said opening and prevented from rotating; and
pulling the new pen needle from one end of said opening to remove the new pen needle, wherein such removal motion serves to pull a slidable internal holder within the assembly forward, thereby creating a space at an opposite end of said opening for a used pen needle to be inserted and stored.

US Pat. No. 10,137,237

NEEDLE ARRANGEMENT

1. A needle arrangement for an injection device comprising:a needle cannula having a lumen and mounted such that a distal part having a distal tip extend in a distal direction,
a telescopically movable shield slidable between a first extended position and a second retracted position and wherein the telescopically movable shield distally carries a cleaning chamber containing a cleaning solvent for cleaning at least the tip of the needle cannula between subsequent injections and which cleaning chamber at least distally is provided with a pierceable distal septum, wherein the telescopically movable shield in the first extended position is extended to at least cover the distal tip of the needle cannula and in the second retracted position is retracted to at least expose the tip of the needle cannula,
a telescopically movable tube for guiding the needle cannula, the telescopically movable tube having a tube lumen and a distal end wherein the needle cannula is guided inside the tube lumen, and which tube lumen is movable relatively to the needle cannula, and wherein the distal end of the telescopically movable tube at least partly penetrates the distal septum when the telescopically movable shield is moved from the first extended position to the second retracted position.

US Pat. No. 10,137,235

AUTOMATED PERITONEAL DIALYSIS SYSTEM USING STEPPER MOTOR

Baxter International Inc....

1. A peritoneal dialysis system comprising:an enclosure;
a stepper motor housed by the enclosure;
a solid pump piston including a solid piston shaft attached to or integrally formed with a solid pump head, the solid pump piston in operable communication with the stepper motor;
a disposable unit including at least one flexible membrane attached to a rigid piece, the enclosure and the disposable unit structured and arranged to allow the flexible membrane to move beyond a relaxed position of the flexible membrane, the enclosure structured and arranged to receive the disposable unit such that the stepper motor can move the solid pump head towards and away from the disposable unit to allow (i) the flexible membrane adjacent to the solid pump head to move outwardly beyond the rigid piece as the solid pump head is moved away from the disposable unit, and (ii) the flexible membrane adjacent to the solid pump head to move within the rigid piece as the solid pump head is moved towards the disposable unit; and
an encoder operable with the stepper motor, the encoder configured to provide an output indicative of a position of the solid pump head after the solid pump head has moved towards or away from the disposable unit.

US Pat. No. 10,137,233

DETECTING PRESSURE PULSES IN A BLOOD PROCESSING APPARATUS

GAMBRO LUNDIA AB, Lund (...

1. An apparatus for extracorporeal blood processing comprising:an extracorporeal blood circuit for connection to the vascular system of a subject;
a blood processing unit in the extracorporeal blood circuit;
a blood pumping device in the extracorporeal blood circuit operable to pump blood through the blood processing unit;
a treatment fluid supply system operable to pump treatment fluid through the blood processing unit;
a first pressure sensor arranged in the extracorporeal blood circuit to detect pressure variations in the blood which is pumped through the blood processing unit;
a second pressure sensor arranged in the treatment fluid supply system to detect pressure variations in the treatment fluid which is pumped through the blood processing unit; and
a monitoring device including
a first input block configured to obtain a first pressure signal (y) from the first pressure sensor, wherein the extracorporeal blood circuit is connected to a vascular system of a subject,
a second input block configured to obtain a second pressure signal (u) from the second pressure sensor,
an emulation block configured to generate, as a function of the second pressure signal (u), an emulated first pressure signal (?) which emulates a signal response of the first pressure sensor concurrently over a period of time of the first pressure signal of the first pressure sensor,
a filtering block configured to generate a filtered signal (yf) as a function of the first pressure signal (y) and the emulated first pressure signal (?), so as to suppress, in the filtered signal (yf) compared to the first pressure signal (y), signal interferences originating from the treatment fluid supply system, and
a pulse detection block configured to process the filtered signal (yf) for detection of subject pulses originating from the subject.

US Pat. No. 10,137,232

TET SYSTEM FOR IMPLANTED MEDICAL DEVICE

HeartWare, Inc., Miami L...

1. A system, comprising:an implantable electrical device including a pump having a motor, the electrical device sized to be received within a body of a patient;
an implantable power unit sized for mounting within the body of the patient and in electrical communication with the implantable electrical device, the power unit having a receiving coil and a power circuit in communication with the receiving coil to transmit power from the receiving coil to the implantable electrical device; and
a power supply external to the patient having:
a transmitting coil adapted for transcutaneous mutual inductive coupling with the receiving coil, the transmitting coil and the receiving coil including a resonant frequency;
a drive circuit configured to apply an alternating current having a variable transmission frequency to the transmitting coil;
a control circuit configured to maintain a difference between the transmission frequency and the resonant frequency; and
a monitoring circuit operable to monitor a condition of the power circuit and to send a transcutaneous telemetry signal representing the monitored condition, the monitoring circuit being configured to measure a voltage at the receiving coil.

US Pat. No. 10,137,231

INTRA-AORTIC BALLOON APPARATUS, ASSIST DEVICES AND METHODS FOR IMPROVING FLOW, COUNTERPULSATION AND HAEMODYNAMICS

1. A circulatory assist apparatus for use to generate pressure and create and augment flow in an aorta or other circulatory lumen, the apparatus comprising:an inflatable pumping balloon having a proximal end joined to an elongated balloon catheter, the balloon catheter having a distal end joined to the pumping balloon and a proximal end, separated from the distal end by a length sufficient to extend from within the circulatory lumen to the outside of a patient's body, for receiving positive and negative pressure pulses from a pump to inflate and deflate the pumping balloon; and
a radially and reversibly expandable frame, mounted on one of a segment extending distally from the pumping balloon, the balloon catheter, and a sleeve tube surrounding the balloon catheter;
wherein the expandable frame is manipulable to expand and collapse within the circulatory lumen, and functions to space apart the inflatable pumping balloon, when inflated, from the circulatory lumen, said expandable frame having a first diameter in a collapsed configuration for intraluminal delivery and withdrawal and a second, larger diameter in an expanded configuration achieved by said manipulation; and
wherein said expandable frame includes a radially and reversibly expandable check valve mounted on said expandable frame and configured to, upon expansion, substantially block flow away from the inflatable pumping balloon and permit flow toward the pumping balloon.

US Pat. No. 10,137,230

SKIN INTERFACE DEVICE HAVING A SKIN ATTACHMENT DEVICE AND METHOD TO IMPLANT SAME

NuPulseCV, Inc., Raleigh...

1. A skin attachment device, comprising:a) an annular ring having a central aperture extending therethrough and defining an inside surface;
b) a fixturing assembly,
wherein the fixturing assembly is adapted to couple to the annular ring via one or more threaded screws which extend through apertures disposed in the fixture assembly and are received by one or more threaded apertures disposed in the annular ring,
wherein the annular ring further comprises a groove extending annularly around an outside surface of the ring thereby defining upper and lower lips,
wherein the upper lip comprises one or more vertical apertures extending therethrough adapted to accept a suture, and
wherein the groove is texturized to promote tissue ingrowth upon implantation of the skin attachment device.

US Pat. No. 10,137,229

TREATING CONGESTIVE HEART FAILURE

Mayo Foundation for Medic...

1. A method for treating heart disease in a mammal using an assist device comprising (i) a conduit comprising a proximal region, a distal region and an intermediate region located between said proximal and distal regions, wherein said proximal region is adapted to be positioned within an aorta of said mammal, wherein said distal region is adapted to be positioned within a left atrium of said mammal, and wherein said intermediate region is adapted to define a lumen through a shared wall between said aorta and said left atrium, and (ii) a pump, wherein said pump is adapted to be positioned within said conduit,wherein said method comprises implanting said assist device with said proximal region positioned within said aorta, said distal region positioned within said left atrium, and said intermediate region positioned to extend from said aorta to said left atrium across said shared wall between said aorta and said left atrium without being positioned outside of said aorta, said left atrium, and said shared wall, wherein said shared wall extends along the ascending aorta to the aortic valve,
wherein blood flow in said mammal is enhanced, thereby treating said heart disease.

US Pat. No. 10,137,228

SYSTEM AND METHOD FOR SEALING AN INCISIONAL WOUND

KCI Licensing, Inc., San...

17. A system to treat an incisional wound having incisional walls, the system comprising:a scaffold fluidly coupled to a conduit to receive reduced pressure from a reduce pressure source, and configured to be positioned within the incisional wound adjacent the incisional walls, the scaffold being formed from an elongated porous material; and
an internal manifold having a primary flow channel extending within the scaffold and configured to be fluidly coupled to the conduit, wherein the primary flow channel is formed by an alignment of interconnected pores of the scaffold.

US Pat. No. 10,137,227

BONE MARROW ASPIRATION DEVICE

SpineSmith Partners, L.P....

6. A method for extracting bone marrow from a subject comprising the steps of:inserting a needle of a bone marrow aspiration device into a bone of a subject, the bone marrow aspiration device comprising:
a housing configured to couple to a first syringe, a second syringe, and a needle;
a first one-way valve disposed within the housing and positioned between the needle and the first syringe, the first one-way valve configured to allow a fluid to only flow from the needle to the first syringe;
a second one-way valve disposed within the housing and positioned between the first syringe and the second syringe, the second one-way valve configured to allow a fluid to flow only from the first syringe to the second syringe; and
a coupler disposed within the housing and joining flow paths of the first syringe, the first one-way valve, and the second one-way valve together;
creating a vacuum in the first syringe sufficient to withdraw bone marrow from the subject through the needle into the first syringe;
filling a portion of the volume of the first syringe with bone marrow;
releasing the bone marrow from the first syringe into the second tubing; and
causing the second syringe to fill with bone marrow from the first syringe.

US Pat. No. 10,137,226

MEDICAL DRAINAGE DEVICES WITH CARBON-BASED STRUCTURES FOR INHIBITING GROWTH OF FIBROBLASTS

Mobius Therapeutics, LLC,...

1. A composition for use in manufacturing an implantable medical device, having a body with an opening therethrough defining a fluid path for passage of body fluids therethrough, the composition comprising:a carbon scaffold consisting essentially fibers combined with a biocompatible polymer; and
a layer of carbon nanotubes grown on the carbon fibers providing a resulting structure and configured to be provided at least on inner walls defining the body of the implantable medical device, the resulting structure forming a carbon fuzzy veil;
wherein: the carbon fuzzy veil resulting from the carbon nanotubes grown on the carbon scaffold is fibroblast-inhibiting relative to a carbon scaffold alone.

US Pat. No. 10,137,223

ALIGNED FIBER AND METHOD OF USE THEREOF

LifeNet Health, Virginia...

1. A scaffold comprising one or more electrospun fibers comprising collagen, wherein a fast Fourier transform (FFT) analysis result of the fibers have adjacent major peaks with about 180° apart from each other.

US Pat. No. 10,137,219

COHERENT BLOOD COAGULATION STRUCTURE OF WATER-INSOLUBLE CHITOSAN AND WATER-DISPERSIBLE STARCH COATING

1. An absorbent layer comprising a non-woven fabric layer of water-insoluble chitosan fibers having a continuous coating of water-absorbent starch on at least one face of the fabric layer, wherein the starch has been modified to include hydrophilic groups into or onto molecular chains of the starch.

US Pat. No. 10,137,217

METHOD AND APPARATUS FOR STERILIZING PREFORM

Dai Nippon Printing Co., ...

1. A method of sterilizing a preform, comprising the steps of:sterilizing bacteria adhering to the preform made of resin by gasifying a sterilizer, discharging a sterilizer gas toward the preform in a chamber whose pressure is lower than atmospheric pressure, now traveling, so as to adhere to the preform by discharging the sterilizer gas from a nozzle;
activating the sterilizer adhering to the preform by blasting hot air to the preform; and
sterilizing the bacteria adhering to the preform, and removing the sterilizer adhering to the preform,
wherein the above-mentioned steps are performed subsequently in order.

US Pat. No. 10,137,216

FLUID DISINFECTION DEVICE AND METHOD

Molekule Inc., San Franc...

1. A device for decontaminating a fluid, comprising: a porous filter medium having a predetermined path of fluid travel therethrough, the porous filter medium comprisinga filter, and
a fiber having a first end and a second end, wherein the first end is fixed to the filter and the second end is freely movable within the predetermined path of fluid travel, wherein the fiber is operable between a first configuration and a second configuration, wherein the fiber is opaque;at least one photocatalytic particle disposed on the fiber between the first and second ends for generating electron-hole pairs and having a cross sectional area normal to the path of fluid travel;a source of photons having a wavelength corresponding to at least a band gap energy of the at least one photocatalytic particle, and arranged to illuminate the at least one photocatalytic particle during device operation; andan agitator coupled to the porous filter medium, the agitator operable to oscillate the fiber, relative to the filter wherein the filter is fixed, between the first configuration and the second configuration during device operation, wherein the at least one photocatalytic particle is swept through an area greater than the cross sectional area in a direction normal to the path of fluid travel.

US Pat. No. 10,137,214

STERILIZATION CONTAINER WITH MOVABLE AND NESTABLE LID

SYMMETRY MEDICAL MANUFACT...

1. A sterilization container comprising:a floor;
a first sidewall connected to a first side of the floor and a second sidewall connected to a second side of the floor, wherein the first side is opposite the second side, wherein each of the first and second sidewalls has an elongated blind cavity formed along a length thereof;
a first hinge positioned partially within the blind cavity of the first sidewall, and a second hinge positioned partially within the blind cavity of the second sidewall, wherein each of the first and second hinges are movable along a length of the first and second blind cavities, respectively; and
a lid connected between the first and second hinges, wherein the lid is positionable between at least a first position substantially parallel with the floor on a third side of the floor, and a second position substantially parallel with the floor on a fourth side of the floor, wherein the third side is substantially opposite the fourth side, wherein the lid and the floor each define a plurality of holes adapted to allow a sterilization fluid to pass therethrough;
further comprising a membrane tray insert positioned between the first and second sidewalls, wherein the membrane tray insert is connected to each of the first and second sidewalls.

US Pat. No. 10,137,213

UV DISINFECTING SYSTEM FOR A DENTAL OPERATORY

KAVO DENTAL TECHNOLOGIES,...

1. A fluid treatment system comprising:a dental instrument adapted to receive a fluid;
a fluid supply line configured to be coupled to the dental instrument and to provide fluid to the dental instrument for use of the fluid during a dental procedure, and
a UV source positioned to be in fluid communication with the fluid such that UV light from the UV source disinfects the fluid;
wherein the UV source includes
a conduit adapted to carry the fluid and having a first index of refraction, the conduit having an outside surface;
a pliable sheath surrounding the conduit, the sheath having an inside surface in contact with the outside surface of the conduit, the sheath having a second index of refraction, the second index of refraction being lower than the first index of refraction, and
a light source configured to produce UV light and arranged to send the UV light into the conduit.

US Pat. No. 10,137,212

TETRAHYDROXAMATE CHELATORS OF ZIRCONIUM89 AND NIOBIUM90 FOR USE IN DIAGNOSTIC APPLICATIONS

The United States of Amer...

1. A compound of formula (I) or (II)whereinZ1-Z4 and Z1?-Z4? are the same or different and each is

R1, R2, R3, R4, R2?, R3?, and R4?, are the same or different and each is —(CR6R7)n— or —(CR8R9)m—X—(CR10R11)m?—,
R1? is —(CR6R7)nR12 or —(CR8R9)m—X—(CR10R11)m?—R12,
R5?, R6, R7, R8, R9, R10, R11, and R12 are the same or different and each is selected from hydrogen, alkyl, alkenyl, cycloalkyl, alkoxy, aryl, aryloxy, heteroaryl, hydroxyalkyl, thioalkyl, thioalkoxy, thioaryl, and an amino acid-containing group, wherein each group other than hydrogen is optionally substituted,
X is O, S, or NR13,
R13 is hydrogen, alkyl, alkenyl, cycloalkyl, aryl, or amino-acid containing group, wherein each group other than hydrogen is optionally substituted,
n is an integer selected from 5-7, and
m and m? are the same or different and each is an integer selected from 0-6, such that 4?(m+m?)?6; and
wherein the compound optionally further comprises a biomolecule
(i) that is covalently linked, either directly or through a linker in the compound of formula (I), to a carbon or nitrogen atom of one or more of R1-R4, or
(ii) that is covalently linked, either directly or through a linker in the compound of formula (II), to carbon or nitrogen atom of one or more of R1?-R5? or a nitrogen atom of one or both of Z1? or Z4?.

US Pat. No. 10,137,211

PROBES FOR IMAGING HUNTINGTIN PROTEIN

CHDI Foundation, Inc., N...

1. An imaging agent comprising a compound of Formula I,or a pharmaceutically acceptable salt thereof, whereinm is 0, 1, or 2;
n is 1 or 2;
J is C(?O) or —CH2-;
X is S or N;
Y is CH or N;
Z is CH or N;
W is N;
for each occurrence, R1 is independently chosen from halo, lower alkoxy, hydroxy, aryl, heteroaryl, cycloalkoxy, or lower alkyl, wherein the lower alkoxy, cycloalkoxy, lower alkyl, aryl, or heteroaryl are each optionally substituted with one, two, or three groups independently selected from lower alkoxy, alkenyl, —NR4R5, halo, or heteroaryl optionally substituted with one to three lower alkoxy;
R2 is hydrogen or lower alkyl; and
R3 is alkyl, aryl, aralkyl, heterocycloalkyl, heterocycloalkenyl, heteroaryl, or heteroaralkyl, each of which is optionally substituted with one, two, or three groups independently chosen from hydroxy, lower alkoxy optionally substituted with lower alkoxy or halo, lower alkyl optionally substituted with halo, halo, heteroaryl, —(CH2)tNR4R5, oxo, cyano, or —C(O)—NR4R5, or
R2 and R3 taken together with the nitrogen to which they are bound form a heterocycloalkyl ring, optionally substituted with one, two, or three groups independently chosen from hydroxy, lower alkoxy, lower alkyl, halo, or —C(O)—NR4R5;
t is 0, 1, or 2;
each R4 is independently chosen from hydrogen or lower alkyl;
each R5 is independently chosen from hydrogen or lower alkyl; or
R4 and R5 taken together with the nitrogen to which they are bound form a heterocycloalkyl ring, optionally substituted with one, two, or three groups independently chosen from hydroxy, lower alkoxy, lower alkyl, halo, or —C(O)—NR6R7;
each R6 is independently chosen from hydrogen or lower alkyl; and
each R7 is independently chosen from hydrogen or lower alkyl;
wherein the compound of Formula I, or a pharmaceutically acceptable salt thereof, is labeled with one or more positron-emitting radionuclides.

US Pat. No. 10,137,210

THIOFLAVIN DERIVATIVES FOR USE IN ANTEMORTEM DIAGNOSIS OF ALZHEIMER'S DISEASE AND IN VIVO IMAGING AND PREVENTION OF AMYLOID DEPOSITION

1. An amyloid binding compound having a structure selected from the group consisting of:wherein at least one of the atoms of the structure is replaced with 3H.

US Pat. No. 10,137,209

GADOLINIUM CHELATE COMPOUNDS FOR USE IN MAGNETIC RESONANCE IMAGING

BAYER PHARMA AKTIENGESELL...

1. A compound of general formula (I), comprising 4, 5, 6, 7 or 8 gadolinium [4,7,10-tris(carboxylatomethyl)-1,4,7,10-tetraazacyclododecan-1-yl] groups,
in which:
represents a group selected from:

in which * on the A group indicates a point of attachment of the A group with R1;
R1 represents, independently from each other, a hydrogen atom or a substituent group selected from:

R3,
in which * on the substituent group indicates a point of attachment of the substituent group with A group,
with the proviso that zero or only one of the R1 groups present in the compound represent a hydrogen atom;
n represents an integer of 3 or 4;
R2 represents, independently from each other, a hydrogen atom or a methyl group;
R3 represents a group selected from:

in which * on the R3 group indicates a point of attachment of the R3 group with a nitrogen on the A group or the substituent group;
R4 represents, independently from each other, a hydrogen atom or a methyl group; and
R5 represents, independently from each other, a hydrogen atom or a methyl group;
or a stereoisomer, a tautomer, an N-oxide, a hydrate, a solvate, or a salt thereof, or a mixture of same.

US Pat. No. 10,137,207

METHODS OF USING OPTICAL AGENTS

MediBeacon, Inc., St. Lo...

1. A process for using a fluorescent agent in a surgical procedure, the process comprising:administering a renally excretable fluorescent agent into the bloodstream of a patient, wherein the renally excretable optical agent is selected from the group consisting of phenylxanthenes, phenothiazines, phenoselenazines, cyanines, indocyanines, squaraines, dipyrrolo pyrimidones, anthraquinones, tetracenes, quinolines, pyrazines, acridines, acridones, phenanthridines, azo dyes, rhodamines, phenoxazines, azulenes, azaazulenes, triphenyl methane dyes, indoles, benzoindoles, indocarbocyanines, benzoindocarbocyanines, derivatives having the general structure of 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene, and conjugates thereof and derivatives thereof;
irradiating a ureter of the patient's renal system with infrared radiation, visible radiation, ultraviolet radiation or combinations thereof to excite the agent in the patient's urine and cause the agent to fluoresce; and
detecting the agent's fluorescence in the irradiated ureter to demarcate the position of the ureter and distinguish the ureter from the surrounding tissue during the surgical procedure, wherein the surgical procedure is selected from an abdominal surgery and a pelvic surgery.

US Pat. No. 10,137,194

IMMUNOGENIC PEPTIDE CONJUGATE AND METHOD FOR INDUCING AN ANTI-INFLUENZA THERAPEUTIC ANTIBODY RESPONSE THEREWITH

The Admininstrators of th...

1. An immunogenic peptide conjugate consisting of a hemagglutinin fusion initiation region (FIR) peptide or a variant thereof, conjugated to an immunogenic carrier protein by a linking group; wherein the hemagglutinin FIR peptide consists of 16 amino acid residues and has an amino acid sequence that consists of SEQ ID NO: 1 or a variant of SEQ ID NO: 1 sharing at least 50% sequence identity therewith and differing from SEQ ID NO: 1 by one or more amino acid substitutions selected from the group consisting of V1I, V1L, V1A, V1G, V1T, V1S, V1M, E2D, E2K, E2R, D3E, T4G, T4S, T4Q, T4A, K5F, K5M, K5I, K5V, K5L, K5A, I6L, I6V, I6A, I6T, I6S, I6Q, I6N, D7E, L8I, L8V, L8A, W9Y, S10T, S10G, S10A, S10M, and E14K; wherein the immunogenic carrier protein is selected from the group consisting of the outer membrane protein complex of Neiserria meningitidis (OMPC), tetanus toxoid protein, diphtheria toxin derivative CRM197, Concholepas concholepas hemocyanin (CCH), hepatitis B virus (HBV) surface antigen protein (HBsAg), HBV core antigen protein, a rotavirus capsid protein, bovine papilloma virus (BPV) L1 protein, a human papilloma virus (HPV) L1 protein, ovalbumin, and a full-length influenza hemagglutinin protein; and wherein the linking group comprises a sulfide bond or a 4-(N-succinimidomethyl)cyclohexane-1-carbonyl group of Formula (I):wherein a primary amine on the carrier protein is bound by an amide bond to the 1-carbonyl moiety of the 4-(N-succinimidomethyl)cyclohexane-1-carbonyl group, and the Cys residue in Formula (I) is bound by peptide bond to the to the N-terminus of the FIR peptide, optionally with an additional spacer peptide of 1 to 5 residues between the Cys and the FIR peptide.

US Pat. No. 10,137,186

COMPOSITIONS AND METHODS FOR LIVE, ATTENUATED ALPHAVIRUS FORMULATIONS

Takeda Vaccines, Inc., C...

1. A live, attenuated alphavirus virus composition comprising:one or more live, attenuated alphaviruses, wherein the live, attenuated alphaviruses are selected from the group consisting of chikungunya (CHIK) virus, o'nyong'nyong virus, Eastern equine encephalitis, Western equine encephalitis, and Venezuelan equine encephalitis;
10.0 mM to 20.0 mM HEPES buffer;
one or more carbohydrate agents having a concentration from 1.0% to 15% (w/v) selected from the group consisting of: trehalose, sucrose, mannitol, sorbitol, and galactose; and
0.1% to 1.0% (w/v) gelatin but does not contain human serum albumin (HSA), wherein the composition stabilizes the live attenuated alphaviruses.

US Pat. No. 10,137,183

PEPTIDE COMPOSITIONS HAVING 4 LINKED CTL EPITOPES AND USES THEREOF

Taiho Pharmaceutical Co.,...

1. A peptide having the general formula: A-(L)-B-(L)-C-(L)-Dwherein (L) is a linker and wherein A, B, C, and D consist of a total of four CTL epitope peptides and are independently selected from the group consisting of:PEP1 as represented by SEQ ID NO: 1;
PEP2 as represented by SEQ ID NO: 2;
PEP4 as represented by SEQ ID NO: 4;
PEP5 as represented by SEQ ID NO: 5;
PEP6 as represented by SEQ ID NO: 6;
PEP7 as represented by SEQ ID NO: 7;
PEP8 as represented by SEQ ID NO: 8;
PEP9 as represented by SEQ ID NO: 9;
PEP10 as represented by SEQ ID NO: 10;
PEP13 as represented by SEQ ID NO: 13;
PEP15 as represented by SEQ ID NO; 15;
PEP17 as represented by SEQ ID NO: 17; and
PEP18 as represented by SEQ II) NO: 18; and wherein
(a) the peptide comprises PEP2 at the C terminus but not when the peptide comprises PEP7 at the N terminus followed by PEP8; or
(b) the peptide comprises PEP4 at the C terminus; or
(c) the peptide comprises PEP10 at the C terminus; or
(d) the peptide comprises PEP5 at the C terminus preceded by PEP6; or
(e) the peptide-consists of PEP5, PEP6, PEP9, and PEP18, and
wherein the peptide optionally comprises hydrophilic amino acids at the N terminus or C terminus to improve solubility of the peptide.

US Pat. No. 10,137,179

COMPOSITION AND METHOD OF PREPARATION OF PROTEASE MICROPARTICULATE SLOW RELEASE PREPARATION

HYALO TECHNOLOGIES, LLC, ...

1. A composition, comprising a plurality of biodegradable polymer microparticies comprising a protease enzyme therein, the biodegradable polymer and the protease enzyme forming a controlled release matrix for extended release of the enzyme; wherein (a) the protease is selected from the group consisting of collagenase, papain, elastase and mixtures thereof; (b) the plurality of the biodegradable polymer microparticies is a mixture of biodegradable polymer microparticles containing different proteases; (c) a first portion of the plurality of the biodegradable polymer microparticles contains collagenase, and (d) a second portion of the plurality of the biodegradable polymer microparticles contains papain or elastase.

US Pat. No. 10,137,161

MEDICAL CANNABIS LOZENGES AND COMPOSITIONS THEREOF

1. A lozenge consisting essentially of extracted cannabis sativa oil, extracted cannabis indica oil, and xylitol, wherein the extracted cannabis sativa oil and the extracted cannabis indica oil comprise cannabidiol and tetrahydrocannabinol.

US Pat. No. 10,137,148

REDUCING THE PROLIFERATION OF ADENOCARCINOMA CELLS (CACO-2) BY ADMINISTRATION OF A POLY-OXYGENATED METAL HYDROXIDE

BAYLOR UNIVERSITY, Waco,...

1. A method of treating a mammal, comprising administering a therapeutically effective amount of a poly-oxygenated aluminum hydroxide composition to the mammal in need thereof to reduce a proliferation of colon adenocarcinoma CaCo-2 cells, wherein the poly-oxygenated aluminum hydroxide composition comprises a clathrate containing fee oxygen gas (O2) molecules; and wherein the therapeutically effective amount of the poly-oxygenated aluminum hydroxide composition ranges from 10 mg/L to 1000 mg/L.

US Pat. No. 10,137,147

REDUCING THE PROLIFERATION OF LUNG CARCINOMA CELLS (A549) BY ADMINISTRATION OF A POLY-OXYGENATED METAL HYDROXIDE

BAYLOR UNIVERSITY, Waco,...

1. A method of treating a mammal, comprising administering a therapeutically effective amount of a poly-oxygenated aluminum hydroxide composition to the mammal in need thereof to reduce a proliferation of lung carcinoma A549 cells, wherein the poly-oxygenated aluminum hydroxide composition comprises a clathrate containing fee oxygen gas (O2) molecules; and wherein the therapeutically effective amount of the poly-oxygenated aluminum hydroxide composition ranges from 10 mg/L to 1000 mg/L.

US Pat. No. 10,137,138

SULFONYLUREA DERIVATIVES OF OLEANOLIC ACID

King Saud University, Ri...

1. A sulfonylurea derivative of oleanolic acid, comprising a compound having the formula:where R is selected from the group consisting H and CH3, or a pharmaceutically acceptable salt thereof.

US Pat. No. 10,137,137

ATP SYNTHASE INHIBITORS AND STEROID ALKALOIDS AND USES THEREOF AS ANTIMICROBIAL AGENTS AND AS POTENTIATORS FOR AMINOGLYCOSIDES AGAINST PATHOGENIC BACTERIA

Socpra Sciences et Genie ...

1. A method for preventing or treating a bacterial infection in a subject or for the disinfection, sterilization and/or antisepsis of an object contaminated by the bacteria by administering to the subject or applying on the object a compound of formula (I):
wherein:
R1 is H; and R2 is —NR5R6; or
R1 is —NR5R6; and R2 is H;
wherein R5 and R6 are identical or different and are selected from the group consisting of H; substituted or unsubstituted alkyl; substituted or unsubstituted aryl; substituted or unsubstituted aralkyl; substituted or unsubstituted cycloalkyl, and substituted or unsubstituted —(CH2)nNR7R8,
wherein n is 2-10; and
R7 and R8 are identical or different and are selected from the group consisting of H, substituted or unsubstituted alkyl, substituted or unsubstituted aryl; substituted or unsubstituted cycloalkyl, and substituted or unsubstituted aralkyl;
wherein the substituted alkyl(s), substituted aryl(s), substituted aralkyl(s), substituted cycloalkyl(s), and substituted —(CH2)nNR7R8 comprise(s) one or more identical or different substitutions selected from alkyl, aryl, cycloalkyl and aralkyl; and
R10 is H, substituted or unsubstituted alkyl, or substituted or unsubstituted —(CH2)pNR13R14,
wherein p is 2-10; and
R13 and R14 are identical or different and are selected from the group consisting of H, substituted or unsubstituted alkyl, substituted or unsubstituted aryl, substituted or unsubstituted cycloalkyl, and substituted or unsubstituted aralkyl;
wherein substituted alkyl, substituted aryl, substituted aralkyl, substituted cycloalkyl, and substituted —(CH2)pNR13R14 comprises one or more identical or different substitutions selected from alkyl, aryl, cycloalkyl and aralkyl,
with the proviso that when R1 is NH2 and R2 is H; or R1 is H and R2 is NH2, R10 is not H,
or a stereoisomer or mixture of stereoisomers or a salt thereof.

US Pat. No. 10,137,134

MOLYBDENUM COMPOUNDS FOR USE IN THE TREATMENT OF CYANIDE POISONING

1. A compound according to the following formula:
Wherein
X is S or a bond; and
R1, R2, and R3 independently or together are one or more of the ligands selected from: a mono- or disaccharide having 3 to 12 carbon atoms, a mono- or di-carboxylic acid having 1 to 5 carbon atoms, which may be substituted with O, S, CH3S— or N, a thiocarboxylic acid having 1 to 5 carbon atoms, a primary, secondary or tertiary amide having 1 to 5 carbon atoms, wherein the side chains attached to the nitrogen is an alkyl having 1 to 5 carbon atoms, threonine, serine, glutamate, malate, oxalate, mercapto succinate, cyanide thiocyanate, thiosulfate, or sulfite; and wherein R3 may be an electron pair.

US Pat. No. 10,137,133

METHODS FOR TREATMENT OF DISEASES

GALERA LABS, LLC, Creve ...

1. A method of treating an inflammatory disease or condition selected from the group consisting of pancreatitis, colitis, inflammatory bowel disease, rheumatoid arthritis, chronic obstructive pulmonary disorder (COPD) and asthma in a human patient, the method comprising administering to the patient 25 mg to 450 mg of a superoxide dismutase mimetic at a rate of at least 100 mg/hr, wherein the superoxide dismutase mimetic corresponds to Formula (GC4419):and X and Y are independently halo ligands.

US Pat. No. 10,137,131

PHARMACEUTICAL COMPOSITIONS COMPRISING MELOXICAM

AXSOME THERAPEUTICS, INC....

1. A dosage form comprising a combination of: 1) a complex of meloxicam with a sulfobutyl ether ?-cyclodextrin (SBE?CD), 2) a bicarbonate, and 3) a triptan; wherein the dosage form contains 400 mg to 600 mg of the bicarbonate, about 5 mg to about 50 mg of meloxicam, and about 50 mg to about 200 mg of SBE?CD; and wherein the dosage form is a solid oral dosage form having a shorter Tmax of meloxicam in a human being than a reference dosage form that: 1) contains the same amount of meloxicam, 2) does not contain an SBE?CD, and 3) does not contain a bicarbonate.

US Pat. No. 10,137,130

METHODS OF TREATMENT OF MALIGNANCIES

Celgene Corporation, Sum...

1. A method of treating acute myeloid leukemia in a subject comprising administering to the subject a mutant isocitrate dehydrogenase 2 (IDH2) inhibitor 2-methyl-1-[(4-[6-(trifluoromethyl)pyridin-2-yl]-6-{[2-(trifluoromethyl)pyridin-4-yl]amino}-1,3,5-triazin-2-yl)amino]propan-2-ol having the following formula:or a pharmaceutically acceptable salt, solvate, or tautomer thereof, wherein the acute myeloid leukemia is characterized by the presence of a mutant allele of IDH2 and the absence of a mutant allele of FLT3.

US Pat. No. 10,137,127

LIQUID FORMULATIONS OF (S)-N-(5-((R)-2-(2,5-DIFLUOROPHENYL)-PYRROLIDIN-1-YL)-PYRAZOLO[1,5-A]PYRIMIDIN-3-YL)-3-HYDROXYPYRROLIDINE-1-CARBOXAMIDE

Loxo Oncology, Inc., Sta...

1. A liquid formulation comprising:(S)—N-(5-((R)-2-(2,5-difluorophenyl)-pyrrolidin-1-yl)-pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide having the formula (I):
a pharmaceutically acceptable salt thereof, or a combination thereof;a ?-cyclodextrin; and
a base;
wherein:
the formulation has a pH of about 2.5 to about 5; and
the compound of formula (I), the pharmaceutically acceptable salt thereof, or the combination thereof, has a concentration of about 15 mg/mL to about 35 mg/mL in the liquid formulation.

US Pat. No. 10,137,125

BENZENESULFONAMIDE DERIVATIVES OF QUINOXALINE, PHARMACEUTICAL COMPOSITIONS THEREOF, AND THEIR USE IN METHODS FOR TREATING CANCER

NEUPHARMA, INC., Foster ...

1. A compound of Formula I:or a pharmaceutically acceptable salt thereof, whereinR1, R2, R3, R4, R5, R6, R8, and R10 are independently hydrogen, cyano, halo, hydroxy, azido, nitro, carboxy, sulfinyl, sulfanyl, sulfonyl, optionally substituted alkoxy, optionally substituted aryloxy, optionally substituted heteroaryloxy, optionally substituted heterocycloalkyloxy, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted aryloxy, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted heterocycloalkyl, optionally substituted amino, optionally substituted acyl, optionally substituted alkoxycarbonyl, optionally substituted aminocarbonyl, optionally substituted aminosulfonyl, optionally substituted carbamimidoyl, or optionally substituted alkynyl;
R7 is halo;
R9 is optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted aryl, or optionally substituted heteroaryl; and
R11 is hydrogen, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted aryl, or optionally substituted heteroaryl.

US Pat. No. 10,137,122

KINASE INHIBITORS AND METHODS OF USE THEREOF

The Broad Institute, Inc....

1. A method of treating Fragile X syndrome comprising administering to a subject suffering from Fragile X syndrome an effective amount of a compound of formula I:
or a pharmaceutically acceptable salt thereof,
wherein:
R1 is selected from the group consisting of optionally substituted phenyl and optionally substituted heteroaryl;
R2 is unsubstituted C1-6 aliphatic or C1-6 aliphatic substituted with one or more instances of halogen;
or R1 and R2 are taken together with their intervening atoms to form optionally substituted, 3- to 7-membered, monocyclic, saturated, carbocyclyl or heterocyclyl, wherein the carbocyclyl or heterocyclyl formed by taking together R1 and R2 is optionally fused to optionally substituted phenyl or optionally substituted heteroaryl;
R3 is selected from the group consisting of hydrogen, halogen, —CN, —NO2, optionally substituted C1-6 aliphatic, —ORA, —N(RB)2, and —SRA;
each RA is independently selected from the group consisting of hydrogen and optionally substituted C1-6 aliphatic;
each RB is independently selected from the group consisting of hydrogen and optionally substituted C1-6 aliphatic;
R4a and R4b are each hydrogen;
R5a and R5b are each independently selected from the group consisting of hydrogen, halogen, —CN, —ORA, —N(RB)2, unsubstituted C1-6 aliphatic, and C1-6 aliphatic substituted with one or more instances of halogen, or R5a and R5b are taken together with their intervening atoms to form unsubstituted, 3- to 7-membered, monocyclic, saturated, carbocyclyl or heterocyclyl; and
R6a and R6b are each hydrogen;
wherein:
each instance of the heteroaryl is independently 5- or 6-membered, monocyclic heteroaryl comprising 1 to 4 ring heteroatoms independently selected from the group consisting of nitrogen, oxygen, and sulfur, as valency allows;
each instance of the heterocyclyl independently comprises 1 to 4 ring heteroatoms independently selected from the group consisting of nitrogen, oxygen, and sulfur, as valency allows;
when any one of the aliphatic, carbocyclyl, heterocyclyl, phenyl, and heteroaryl referred to above is substituted with one or more substituents at a carbon atom, the one or more substituents at the carbon atom are independently selected from Group (i);
when any one of the heterocyclyl and heteroaryl referred to above is substituted with one or more substituents at a nitrogen atoms, the one or more substituents at the nitrogen atom are independently selected from Group (ii);
Group (i) consists of halogen, —CN, —NO2, —N3, —SO2H, —SO3H, —OH, —ORaa, —ON(Rbb)2, —N(Rbb)2, —N(Rbb)3+X?, —N(ORcc)Rbb, —SH, —SRaa, —SSRcc, —C(?O)Raa, —CO2H, —CHO, —C(ORcc)2, —CO2Raa, —OC(?O)Raa, —OCO2Raa, —C(?O)N(Rbb)2, —OC(?O)N(Rbb)2, —NRbbC(?O)Raa, —NRbbCO2Raa, —NRbbC(?O)N(Rbb)2, —C(?NRbb)Raa, —C(?NRbb)ORaa, —OC(?NRbb)Raa, —OC(?NRbb)ORaa, —C(?NRbb)N(Rbb)2, —OC(?NRbb)N(Rbb)2, —NRbbC(?NRbb)N(Rbb)2, —C(?O)NRbbSO2Raa, —NRbbSO2Raa, —SO2N(Rbb)2, —SO2Raa, —SO2ORaa, —OSO2Raa, —S(?O)Raa, —OS(?O)Raa, —Si(Raa)3, —OSi(Raa)3—C(?S)N(Rbb)2, —C(?O)SRaa, —C(?S)SRaa, —SC(?S)SRaa, —SC(?O)SRaa, —OC(?O)SRaa, —SC(?O)ORaa, —SC(?O)Raa, —P(?O)(Raa)2, —OP(?O)(Raa)2, —OP(?O)(ORcc)2, —P(?O)(NRbb)2, —OP(?O)(NRbb)2, —NRbbP(?O)(ORcc)2, —NRbbP(?O)(NRbb)2, —P(Rcc)2, —OP(Rcc)2, —B(Raa)2, —B(ORcc)2, —BRaa(ORcc), C1-10 alkyl, C1-10 perhaloalkyl, C2-10 alkenyl, C2-10 alkynyl, C3-10 carbocyclyl, 3-14 membered heterocyclyl, C6-14 aryl, and 5-14 membered heteroaryl, wherein each alkyl, alkenyl, alkynyl, carbocyclyl, heterocyclyl, aryl, and heteroaryl is independently substituted with 0, 1, 2, 3, 4, or 5 Rdd groups; or two geminal hydrogens on a carbon atom are replaced with the group ?O, ?S, ?NN(Rbb)2, ?NNRbbC(?O)Raa, ?NNRbbC(?O)ORaa, ?NNRbbS(?O)2Raa, ?NRbb, or ?NORcc; and
Group (ii) consists of hydrogen, —OH, —ORaa, —N(Rcc)2, —CN, —C(?O)Raa, —C(?O)N(Rcc)2, —CO2Raa, —SO2Raa, —C(?NRbb)Raa, —C(?NRcc)ORaa, —C(?NRcc)N(Rcc)2, —SO2N(Rcc)2, —SO2Rcc, —SO2ORcc, —SORaa, —C(?S)N(Rcc)2, —C(?O)SRcc, —C(?S)SRcc, —P(?O)(Raa)2, —P(?O)(NRcc)2, C1-10 alkyl, C1-10 perhaloalkyl, C2-10 alkenyl, C2-10 alkynyl, C3-10 carbocyclyl, 3-14 membered heterocyclyl, C6-14 aryl, and 5-14 membered heteroaryl, wherein each alkyl, alkenyl, alkynyl, carbocyclyl, heterocyclyl, aryl, and heteroaryl is independently substituted with 0, 1, 2, 3, 4, or 5 Rdd groups;
wherein:
each instance of Raa is, independently, selected from C1-10 alkyl, C1-10 perhaloalkyl, C2-10 alkenyl, C2-10 alkynyl, C3-10 carbocyclyl, 3-14 membered heterocyclyl, C6-14 aryl, and 5-14 membered heteroaryl, or two Raa groups are joined to form a 3-14 membered heterocyclyl or 5-14 membered heteroaryl ring, wherein each alkyl, alkenyl, alkynyl, carbocyclyl, heterocyclyl, aryl, and heteroaryl is independently substituted with 0, 1, 2, 3, 4, or 5 Rdd groups;
each instance of Rbb is, independently, selected from hydrogen, —OH, —ORaa, —N(Rcc)2, —CN, —C(?O)Raa, —C(?O)N(Rcc)2, —CO2Raa, —SO2Raa, —C(?NRcc)ORaa, —C(?NRcc)N(Rcc)2, —SO2N(Rcc)2, —SO2Rcc, —SO2OR, —SORaa, —C(?S)N(Rcc)2, —C(?O)SRcc, —C(?S)SRcc, —P(?O)(Raa)2, —P(?O)(NRcc)2, C1-10 alkyl, C1-10 perhaloalkyl, C2-10 alkenyl, C2-10 alkynyl, C3-10 carbocyclyl, 3-14 membered heterocyclyl, C6-14 aryl, and 5-14 membered heteroaryl, or two Rbb groups are joined to form a 3-14 membered heterocyclyl or 5-14 membered heteroaryl ring, wherein each alkyl, alkenyl, alkynyl, carbocyclyl, heterocyclyl, aryl, and heteroaryl is independently substituted with 0, 1, 2, 3, 4, or 5 Rdd groups;
each instance of Rcc is, independently, selected from hydrogen, C1-10 alkyl, C1-10 perhaloalkyl, C2-10 alkenyl, C2-10 alkynyl, C3-10 carbocyclyl, 3-14 membered heterocyclyl, C6-14 aryl, and 5-14 membered heteroaryl, or two Rcc groups are joined to form a 3-14 membered heterocyclyl or 5-14 membered heteroaryl ring, wherein each alkyl, alkenyl, alkynyl, carbocyclyl, heterocyclyl, aryl, and heteroaryl is independently substituted with 0, 1, 2, 3, 4, or 5 Rdd groups;
each instance of Rdd is, independently, selected from halogen, —CN, —NO2, —N3, —SO2H, —SO3H, —OH, —ORee, —ON(Rff)2, —N(Rff)2, —N(Rff)3+X?, —N(ORee)Rff, —SH, —SRee, —SSRee, —C(?O)Ree, —CO2H, —CO2Ree, —OC(?O)Ree, —OCO2Ree, —C(?O)N(Rff)2, —OC(?O)N(Rff)2, —NRffC(?O)Ree, —NRffCO2Ree, —NRffC(?O)N(Rff)2, —C(?NRff)ORee, —OC(?NRff)Ree, —OC(?NRff)ORee, —C(?NRff)N(Rff)2, —OC(?NRff)N(Rff)2, —NRffC(?NRff)N(Rff)2, —NRffSO2Ree, —SO2N(Rff)2, —SO2Ree, —SO2ORee, —OSO2Ree, —S(?O)Ree, —Si(Ree)3, —OSi(Ree)3, —C(?S)N(Rff)2, —C(?O)SRee, —C(?S)SRee, —SC(?S)SRee, —P(?O)(Ree)2, —OP(?O)(Ree)2, —OP(?O)(ORee)2, C1-6 alkyl, C1-6 perhaloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocyclyl, 3-10 membered heterocyclyl, C6-10 aryl, 5-10 membered heteroaryl, wherein each alkyl, alkenyl, alkynyl, carbocyclyl, heterocyclyl, aryl, and heteroaryl is independently substituted with 0, 1, 2, 3, 4, or 5 Rgg groups, or two geminal Rdd substituents can be joined to form ?O or ?S;
each instance of Ree is, independently, selected from C1-6 alkyl, C1-6 perhaloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocyclyl, C6-10 aryl, 3-10 membered heterocyclyl, and 3-10 membered heteroaryl, wherein each alkyl, alkenyl, alkynyl, carbocyclyl, heterocyclyl, aryl, and heteroaryl is independently substituted with 0, 1, 2, 3, 4, or 5 Rgg groups;
each instance of Rff is, independently, selected from hydrogen, C1-6 alkyl, C1-6 perhaloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocyclyl, 3-10 membered heterocyclyl, C6-10 aryl and 5-10 membered heteroaryl, or two Rff groups are joined to form a 3-14 membered heterocyclyl or 5-14 membered heteroaryl ring, wherein each alkyl, alkenyl, alkynyl, carbocyclyl, heterocyclyl, aryl, and heteroaryl is independently substituted with 0, 1, 2, 3, 4, or 5 Rgg groups;
each instance of Rgg is, independently, halogen, —CN, —NO2, —N3, —SO2H, —SO3H, —OH, —OC1-6 alkyl, —ON(C1-6 alkyl)2, —N(C1-6 alkyl)2, —N(C1-6 alkyl)3+X?, —NH(C1-6 alkyl)2+X?, —NH2(C1-6 alkyl)+X?, —NH3+X?, —N(OC1-6 alkyl)(C1-6 alkyl), —N(OH)(C1-6 alkyl), —NH(OH), —SH, —SC1-6 alkyl, —SS(C1-6 alkyl), —C(?O)(C1-6 alkyl), —CO2H, —CO2(C1-6 alkyl), —OC(?O)(C1-6 alkyl), —OCO2(C1-6 alkyl), —C(?O)NH2, —C(?O)N(C1-6 alkyl)2, —OC(?O)NH(C1-6 alkyl), —NHC(?O)(C1-6 alkyl), —N(C1-6 alkyl)C(?O)(C1-6 alkyl), —NHCO2(C1-6 alkyl), —NHC(?O)N(C1-6 alkyl)2, —NHC(?O)NH(C1-6 alkyl), —NHC(?O)NH2, —C(?NH)O(C1-6 alkyl), —OC(?NH)(C1-6 alkyl), —OC(?NH)OC1-6 alkyl, —C(?NH)N(C1-6 alkyl)2, —C(?NH)NH(C1-6 alkyl), —C(?NH)NH2, —OC(?NH)N(C1-6 alkyl)2, —OC(NH)NH(C1-6 alkyl), —OC(NH)NH2, —NHC(NH)N(C1-6 alkyl)2, —NHC(?NH)NH2, —NHSO2(C1-6 alkyl), —SO2N(C1-6 alkyl)2, —SO2NH(C1-6 alkyl), —SO2NH2, —SO2C1-6 alkyl, —SO2OC1-6 alkyl, —OSO2C1-6 alkyl, —SOC1-6 alkyl, —Si(C1-6 alkyl)3, —OSi(C1-6 alkyl)3 —C(?S)N(C1-6 alkyl)2, C(?S)NH(C1-6 alkyl), C(?S)NH2, —C(?O)S(C1-6 alkyl), —C(?S)SC1-6 alkyl, —SC(?S)SC1-6 alkyl, —P(?O)(C1-6 alkyl)2, —OP(?O)(C1-6 alkyl)2, —OP(?)(OC1-6 alkyl)2, C1-6 alkyl, C1-6 perhaloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocyclyl, C6-10 aryl, 3-10 membered heterocyclyl, 5-10 membered heteroaryl; or two geminal Rgg substituents can be joined to form ?O or ?S; and
X? is a counterion, wherein the counterion is a halide ion, NO3?, ClO4?, OH?, H2PO4?, HSO4?, a sulfonate ion, or a carboxylate ion.

US Pat. No. 10,137,120

AZA-ARYL 1H-PYRAZOL-1-YL BENZENE SULFONAMIDES

ChemoCentryx, Inc., Moun...

1. A compound of the following formula:

US Pat. No. 10,137,119

ANTI-MALARIAL AGENT

RIKEN, Wako (JP)

1. A method of treating, malaria comprising administering a therapeutically effective amount of one or more compounds selected from the group consisting of(a) a compound of the Formula (III)
whereineach hydrogen (H) is optionally independently substituted with a halogen, C1-C10alkyl, C1-C10 alkoxy, phenyl, hydroxyl (—OH), carboxyl (—COOH), amino (—NH2), benzamide (—NHCOC6H5), benzylamino (—NHCH2C6H5), tert-butylamide (—NHCO-tBu), neopentylamino (—NHCH2-tBu), —C(?O)OR, —S(?O)2OR, or —OP(?O)(OR)(OR?);
R and R? each independently represent hydrogen or C1-C10 alkyl; and further,
each hydrogen (H) in the alkyl, alkoxy, phenyl, “—C6H5” of the benzamide, “—C6H5” of the benzylamino, “-tBu” of the tert-butylamide, and “—CH2—” and “-tBu” of the neopentylamino is optionally independently substituted with a halogen, hydroxyl, amino, —C(?O)OR, —S(?O)2OR, or —OP(?O)(OR)(OR?), and
(b) pharmaceutically acceptable salts and metal complexes thereof, to a subject suffering from malaria.

US Pat. No. 10,137,118

CRYSTALLINE POLYMORPHS OF THE FREE BASE OF 2-HYDROXY-6-((2-(1-ISOPROPYL-1H-PYRAZOL-5-YL)PYRIDIN-3-YL)METHOXY)BENZALDEHYDE

Global Blood Therapeutics...

1. A crystalline ansolvate of Compound 1:
characterized by at least three X-ray powder diffraction peaks (Cu K? radiation) selected from 11.65°, 11.85°, 12.08°, 16.70°, 19.65° and 23.48 °2? (each ±0.2 °2?).

US Pat. No. 10,137,117

CRYSTALLINE N-[5-(AMINOSULFONYL)-4-METHYL-1,3-THIAZOL-2-YL]-N-METHYL-2[4-(2-PYRIDINYL)PHENYL]ACETAMIDE MONO MESYLATE MONOHYDRATE HAVING A SPECIFIC PARTICLE SIZE DISTRIBUTION RANGE AND A SPECIFIC SURFACE AREA RANGE FOR USE IN PHARMACEUTICAL FORMULATIONS

AiCuris Anti-Infective Cu...

1. A composition of crystalline N-[5-(aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-N-methyl-2-[4-(2-pyridinyl)-phenyl]acetamide mono methanesulfonic acid monohydrate particles of the following formula
having a purity of >99%,
wherein said particles in the composition have a particle size range from 2 ?m to 500 ?m, a particle size distribution which is defined by d(0.1) from 2 to 100 ?m, d(0.5) from 30 to 210 ?m and d(0.9) from 70 to 400 ?m and a specific surface area of less than 1.0 m2/g.

US Pat. No. 10,137,116

BENZIMIDAZOLE SULFIDE DERIVATIVES FOR THE TREATMENT OR PREVENTION OF TUBERCULOSIS

1. A method of treating tuberculosis in a subject comprising administering to a subject in need thereof a therapeutically effective amount of a benzimidazole sulfide derivative of general formula (I):wherein R is selected from the group consisting of hydrogen, C1-C6-alkyl, C1-C6-heteroalkyl, C1-C6-haloalkyl, aryl, C1-C6-alkyl aryl, heteroaryl, C1-C6-alkyl heteroaryl, C2-C6-alkenyl, C2-C6-alkenyl aryl, C2-C6-alkenyl heteroaryl, C3-C8-cycloalkyl, C1-C6-alkyl cycloalkyl, heterocycloalkyl, C1-C6-alkyl heterocycloalkyl, carboxy, C1-C6-alkyl carboxy, acyl, C1-C6-alkyl acyl, acyloxy, C1-C6-alkyl acyloxy, alkoxy, C1-C6-alkoxy, C1-C6-heteroalkoxy, C1-C6-haloalkoxy, C1-C6-alkoxycarbonyl, halogen, sulfanyl, and C1-C6-alkylsulfanyl, a pharmaceutically acceptable salt thereof, and/or a mixture thereof.

US Pat. No. 10,137,110

1-CYCLOHEXYL-2-PHENYLAMINOBENZIMIDAZOLES AS MIDH1 INHIBITORS FOR THE TREATMENT OF TUMORS

Bayer Pharma Aktiengesell...

1. A compound of formula (I)
wherein:
R1 is a halogen atom or a group selected from the group consisting of:
C1-C6-alkyl, C1-C6-alkoxy, C1-C6-haloalkyl, C1-C6-haloalkoxy, cyano, (C1-C6-alkyl)-S—, and (C1-C6-haloalkyl)-S—;
R2 is a hydrogen atom;
R3 is a hydrogen atom;
R4 is a hydrogen atom;
R5 is a phenyl or heteroaryl group,
wherein said phenyl or heteroaryl group is optionally substituted with one or more substituents independently selected from the group consisting of:
halo-, cyano, C1-C6-alkyl, C3-C6-cycloalkyl, C1-C6-haloalkyl, C1-C6-haloalkoxy, nitro, R13O—, R13S—, R13OC(?O)—(C1-C6-alkyl)-, R13OC(?O)—(C2-C6-alkenyl)-, R13OC(?O)—(C1-C6-alkoxy)-, R14(R15)NC(?O)—(C1-C6-alkyl)-, R14(R15)NC(?O)—(C2-C6-alkenyl)-, R14(R15)NC(?O)—(C1-C6-alkoxy)-, (C1-C6-alkyl)-S—, (C1-C6-alkyl)-S(?O)—, (C1-C6-alkyl)-S(?O)2—, (C1-C6-haloalkyl)-S—, —C(?O)OR13, —C(?O)N(R14)R15, —C(?O)N(R14)S(?O)2R16, —N(R14)R15, —N(R14)C(?O)R16, —N(R14)C(?O)R17, —N(R14)S(?O)2R16, —S(?O)2OR13, and —S(?O)2N(R14)R15;
R6 is a hydrogen atom, a halogen atom, or a group selected from the group consisting of C1-C6-alkyl and C1-C6-alkoxy;
R7 is a hydrogen atom;
R8 is C1-C3-alkyl;
R9, R10, and R11
are independently selected from the group consisting of hydrogen and C1-C3-alkyl;
R12 is a hydrogen atom;
R13 is a hydrogen atom or a group selected from the group consisting of:
C1-C6-alkyl, C3-C6-cycloalkyl, HO—(C2-C6-alkyl)-, and (C1-C3-alkoxy)-(C2-C6-alkyl)-;
R14 and R15
are independently selected from the group consisting of:
hydrogen, C1-C6-alkyl, C3-C6-cycloalkyl, HO—(C2-C6-alkyl)-, (C1-C3-alkoxy)-(C2-C6-alkyl)-, H2N—(C2-C6-alkyl)-, (C1-C3-alkyl)N(H)(C2-C6-alkyl)-, (C1-C3-alkyl)2N(C2-C6-alkyl)-, R13OC(?O)—(C1-C6-alkyl)-, 4- to 6-membered heterocycloalkyl, phenyl, heteroaryl, phenyl-(C1-C6-alkyl)-, and
heteroaryl-(C1-C6-alkyl)-,
wherein said phenyl and heteroaryl groups are optionally substituted with one or two substituents independently selected from the group consisting of:
C3-C6-cycloalkyl, C1-C3-alkoxy, C3-C6-cycloalkyloxy, C1-C3-haloalkoxy, halogen, cyano, —C(?O)OR13, and —C(?O)NH2;
or
R14 and R15
are taken together with the nitrogen atom to which they are attached to form a 4-6-membered heterocycloalkyl,
wherein said 4-6-membered heterocycloalkyl is optionally substituted with one substituent selected from the group consisting of:
C1-C3-alkyl C1-C3-haloalkyl C1-C3-alkoxy, C1-C3-haloalkoxy, C3-C6-cycloalkyl, C3-C6-cycloalkyloxy, amino, hydroxy, halogen, and cyano,
or
wherein said 4-6-membered heterocycloalkyl is optionally substituted with one or two halogen atoms;
R16 is a hydrogen atom or a group selected from the group consisting of:
C1-C6-alkyl, C3-C6-cycloalkyl, HO—(C3-C6-cycloalkyl)-, C1-C6-haloalkyl, (C1-C3-alkoxy)-(C1-C6-alkyl)-, phenyl, heteroaryl, and 4- to 6-membered heterocycloalkyl,
wherein said phenyl and heteroaryl groups are optionally substituted with one or two substituents independently selected from the group consisting of:
C1-C3-alkyl, C3-C6-cycloalkyl, C1-C3-alkoxy, C3-C6-cycloalkyloxy, C1-C3-haloalkyl, C1-C3-haloalkoxy, halogen, cyano, —C(?O)OR13, and —C(?O)N(R14)R15; and
R17 is a group selected from the group consisting of —N(R14)R15 and C1-C6-alkoxy,
or a stereoisomer, a tautomer, an N-oxide, a hydrate, a solvate, or a salt thereof, or a mixture of any of the foregoing.

US Pat. No. 10,137,109

CARBAZOLE COMPOUNDS AND THERAPEUTIC USES OF THE COMPOUNDS

INCURON, INC., Buffalo, ...

1. A method for treating melanoma, comprising intraarterially administering to a patient in need thereof an effective amount of a compound of a structural formula:
wherein Ra is selected from the group consisting of C1-6 alkyl, C1-6 haloalkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, ORe, N(Re)2, and SRe; alternatively, either Ra and R1 or NRe and R1 together with the carbon atoms to which they are attached form a five or six-membered aliphatic carbocyclic or heterocyclic ring;
Rb is selected from the group consisting of C1-6 alkyl, C1-6 haloalkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, ORe, N(Re)2, and SRe, alternatively, either Rb and R6 or NRe and R6 together with the carbon atoms to which they are attached form a five or six-membered aliphatic carbocyclic ring or a five or six-membered aliphatic carbocyclic or heterocyclic ring;
Rc is selected from the group consisting of hydrogen, C1-6 alkyl, C1-6 hydroxyalkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, and C(?O)Re, or Rc and Rd are taken together to form a five, six, or seven-membered aliphatic ring, optionally containing an oxygen atom;
Rd is selected from the group consisting of hydrogen, C1-6alkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, and C(?O)Re, or Rd and R7 together with the atoms to which they are attached form a five or six-membered aliphatic ring;
Re, independently, is selected from the group consisting of hydrogen, C1-6alkyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl, or two Re groups taken together with a nitrogen to which they are attached to form a five or six-membered aliphatic ring;
R1, R2, R3, R4, R5, and R6, independently, are selected from the group consisting of hydrogen, C1-6alkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, halo, ORe, C(?O)Re, C(?O)ORe, OC(?O)Re, C(?O)N(Re)2, C(?O)NReSO2Re, N(Re)2, NReC(?O)Re, NReC(?O)N(Re)2, CN, NO2, CF3, OCF3, SRe, SORe, SO2N(Re)2, and OSO2CF3;
R7 is selected from the group consisting of hydrogen, C1-6alkyl, cycloalkyl, heterocycloalkyl, aryl, and heteroaryl; and
n is 1, 2, 3, 4, or 5,
or a pharmaceutically acceptable salt or hydrate thereof and
wherein the intraarterial administration is intraarterial infusion.

US Pat. No. 10,137,105

COMBINATION TREATMENT PROTOCOL

Bionomics Limited, Theba...

1. A method for treating chronic lymphocytic leukemia (CLL) in a patient comprising the step of administering effective amounts of (i) a compound which induces egress of CLL cells from lymph node or bone marrow or a pharmaceutically acceptable salt, solvate, stereoisomer or prodrug thereof; and (ii) a compound of Formula (I):or a pharmaceutically acceptable salt, solvate or prodrug thereof, in either order or simultaneously.

US Pat. No. 10,137,103

COMPOSITIONS AND METHODS FOR THE TREATMENT OF FATTY ACID METABOLISM DISORDERS

1. A method for treating a fatty acid oxidation disorder in a subject, said method comprising administering at least one S-nitrosylating agent to said subject,wherein said S-nitrosylating agent is a mononitrated-diheptanoin.

US Pat. No. 10,137,102

OLIGOMERIC FORMS OF 3-HYDROXYBUTYRATE

1. A method of treatment of an individual having an ophthalmic disorder, said method comprising:administering to the individual a therapeutically effective amount of a molecule of general formula I,
whereinn is an integer 1 or 2, andZ is selected from a carboxylic acid, its pharmaceutically acceptable salt or ester and the disorder is associated with oxidative stress.

US Pat. No. 10,137,093

MILRINONE CONTROLLED-RELEASE FORMULATION

Cardiora Pty Ltd., Melbo...

1. An oral controlled-release formulation comprising:(i) a core comprising:
(a) milrinone, or a pharmaceutically acceptable salt thereof;
(b) hydroxypropylmethylcellulose having a viscosity of 80,000 to 120,000 cps:
hydroxypropylmethylcellulose having a viscosity of about 50 cps;
and at least one pharmaceutically acceptable excipient;
and
(ii) a sustained release coating; and
(iii) an enteric coating; wherein the formulation permits the release of milrinone, or a pharmaceutically acceptable salt thereof, into the bloodstream in an amount that is effective to ameliorate symptoms of heart failure for a period of at least 6 hours,
wherein the hydroxypropylmethylcellulose (80,000 to 120,000 cps) and the hydroxypropylmethylcellulose (about 50 cps) are in a ratio of about 1.5:1 to 1:1.5, and the ratio of milrinone, or a pharmaceutically acceptable salt thereof, to total hydroxypropylmethylcellulose is about 1:3 to 1:5, and
wherein the formulation exhibits zero order release of about 100% of milrinone, or a pharmaceutically acceptable salt thereof, over about 12 hours at pH 6.8.

US Pat. No. 10,137,092

DOUBLE-LAYER TABLET AND PREPARATION METHOD THEREOF

1. A method of preparing a double-layer tablet comprising an upper layer on top of a lower layer, comprising:1) pressing a first active ingredient and a first pharmaceutically acceptable excipient to form the upper layer, wherein the upper layer is a sustained-release layer and comprises one or more holes, and the diameter of each hole is between about 2 mm and about 6 mm; and
2) pressing the upper layer onto a second active ingredient and a second pharmaceutically acceptable excipient, which are configured to form the lower layer, to form the double-layer tablet comprising the upper layer on top of the lower layer,
thereby part of the second active ingredient and the second pharmaceutically acceptable excipient of the lower layer are filled into the hole(s) of the upper layer.

US Pat. No. 10,137,090

NOZZLE, APPARATUS, AND METHOD FOR PRODUCING MICROPARTICLES

1. A nozzle for producing microparticles, comprising:a nozzle body including a first fluid passageway therein, with a plurality of extension tubes communicated with an end of the first fluid passageway and spaced from each other, with each of the plurality of extension tubes including a distant end having an outlet port and located distant to the first fluid passageway; and
a cover mounted to the nozzle body and including a second fluid passageway having an end, with a plurality of sleeves communicated with the end of the second fluid passageway, with each of the plurality of sleeves including a far end having an opening and located distant to the second fluid passageway, wherein the nozzle body and the cover are detachable from each other,
with each of the plurality of extension tubes extending into one of the plurality of sleeves, with each of the plurality of extension tubes having an outer wall spaced from an inner wall of the one of the plurality of sleeves by a spacing, with the outlet port of each of the plurality of extension tubes located between the second fluid passageway and the opening of the one of the plurality of sleeves.

US Pat. No. 10,137,089

SOLVENT EXTRACTION FROM BIODEGRADABLE MICROPARTICLES

Rezolute, Inc, Louisvill...

1. A system for reducing a solvent concentration in a plurality of microparticles, the system comprising:an emulsifier that mixes an oil phase from an oil phase mix tank and a water phase from a water phase mix tank;
a first solvent extraction tank in fluid communication with the emulsifier;
a concentration unit in fluid communication with the first solvent extraction tank, the concentration unit comprising a cross-flow filtration column in fluid communication with a second solvent extraction tank;
a washing unit adapted to receive a microparticle concentrate from the concentration unit; and
a water tank separate from the water phase mix tank;
wherein:
the water tank is in fluid communication with the concentration unit without passing through the emulsifier, the first solvent extraction tank, or the washing unit,
the water tank is in fluid communication with the first solvent extraction tank without passing through the emulsifier, the concentration unit, or the washing unit,
the first solvent extraction tank comprises a mixer to keep the microparticles from settling to the bottom of the first solvent extraction tank,
the cross-flow filtration column is operable to remove water and a solvent from the second solvent extraction tank without removing the microparticles, and
the cross-flow filtration column comprises a ceramic membrane.

US Pat. No. 10,137,088

THERAPEUTIC NANOPARTICLES HAVING EGFR LIGANDS AND METHODS OF MAKING AND USING SAME

Pfizer Inc., New York, N...

1. A therapeutic nanoparticle, comprising:about 0.2 to about 35 weight percent of a therapeutic agent; and
about 50 to about 98 weight percent of a diblock poly(lactic)acid-poly(ethylene)glycol copolymer or a diblock poly(lactic)-co-poly(glycolic)acid-poly(ethylene)glycol copolymer; and
about 2% to about 12% PLA-PEG-EGFR ligand density, wherein the EGFR ligand is bound or associated to an azide functionalized PEG-PLA, wherein PLA is poly(lactic)acid and PEG is poly(ethylene)glycol; and wherein the EGFR ligand is a peptidyl ligand comprising a sequence selected from the group consisting of: Ac-DPCTWEVWGRECLQGGK(PEG4-DBCO)-CONH2 (SEQ ID NO: 185), Ac-DACTWEVWGRECLQGGK(PEG4-DBCO)-CONH2 (SEQ ID NO: 186), Ac-DPCT(2Ind)GEV(5MeO)WGRECLQGGK(PEG4-DBCO)-CONH2(SEQ ID NO: 187), Ac-DPPenTWEVWGREPenLQGGK(PEG4-DBCO)-CONH2 (SEQ ID NO: 188), AcDAPenTWEVWGREPenLQGGK(DBCO)-CONH2 (SEQ ID NO: 189), Ac-DACT(2Ind)GEV(5MeO)WGRECLQGGK(DBCO)-CONH2 (SEQ ID NO: 190), Ac-DPPenT(2Ind)GEV(5MeO)WGREPenLQGGK(DBCO)-CONH2 (SEQ ID NO: 191), Ac-DAPenT(2Ind)GEV(5MeO)WGREPenLQGGK(DBCO)-CONH2 (SEQ ID NO: 192), Ac-DAPenTWEVWGREPenLQGGK(DBCO)-CONH2 (SEQ ID NO: 193), Ac-DPCTWEVWGRECLQGGK(PEGS-DBCO)-CONH2 (SEQ ID NO: 194), Ac-DACT (2Ind)GEV(5MeO)WGRECLQGGK(DBCO)-CONH2 (SEQ ID NO: 195), AcDPPenT(2Ind)GEV(5MeO)WGREPenLQGGK(DBCO)-CONH2 (SEQ ID NO: 196), and AcDAPenT(2Ind)GEV(5MeO)WGREPenLQGGK(DBCO)-CONH2 (SEQ ID NO: 197), Ac-DPCTWEVWGRECLQGGK(PEG5-DBCO)-CONH2 (SEQ ID NO: 198), or modifications thereof.

US Pat. No. 10,137,087

LIPID-DERIVED NEUTRAL NANOPARTICLES

Translate Bio, Inc., Lex...

1. A composition comprising a lipid nanoparticle having an overall neutral surface charge and encapsulating negatively charged mRNA, wherein said lipid nanoparticle is made by a method comprising the steps of:(a) encapsulating said negatively charged mRNA within a lipid nanoparticle, wherein the lipid nanoparticle comprises:
a cationic lipid, the cationic lipid comprising a polar head-group bound to a lipophilic tail-group via a linker group, the polar head-group being exposed on the surface of the lipid nanoparticle, and the linker group being susceptible to chemical or enzymatic cleavage;
a PEG-modified lipid;
one or more non-cationic lipids that is zwitterionic or anionic; and
one or more non-cationic lipids that is neutral;
and
(b) exposing the lipid nanoparticle to chemical or enzymatic cleavage thereby releasing the polar head-group from the surface of the lipid nanoparticle to provide an overall neutral surface charge to the lipid nanoparticle.

US Pat. No. 10,137,086

LIPID-DERIVED NEUTRAL NANOPARTICLES

Translate Bio, Inc., Lex...

1. A composition comprising a lipid nanoparticle having an overall neutral surface charge and encapsulating negatively charged mRNA encoding cystic fibrosis transmembrane conductance regulator (CFTR) protein, wherein said lipid nanoparticle is made by a method comprising the steps of:(a) encapsulating said negatively charged mRNA encoding cystic fibrosis transmembrane conductance regulator (CFTR) protein within a lipid nanoparticle, wherein the lipid nanoparticle comprises:
a cationic lipid, the cationic lipid comprising a polar head-group bound to a lipophilic tail-group via a linker group, the polar head-group being exposed on the surface of the lipid nanoparticle, and the linker group being susceptible to chemical or enzymatic cleavage;
a PEG-modified lipid;
one or more non-cationic lipids that is zwitterionic or anionic; and
one or more non-cationic lipids that is neutral;
and
(b) exposing the lipid nanoparticle to chemical or enzymatic cleavage thereby releasing the polar head-group from the surface of the lipid nanoparticle to provide an overall neutral surface charge to the lipid nanoparticle.

US Pat. No. 10,137,078

METHODS FOR INTRAVESICAL DRUG DELIVERY AND METHODS AND SYSTEMS FOR LOADING DEVICES WITH DRUG TABLETS

TARIS Biomedical LLC, Le...

1. A method for administration of a drug into the urinary bladder of a patient, the method comprising:deploying into the urinary bladder of the patient a drug delivery device which comprises (i) elastic walls defining a drug reservoir lumen and a retention frame lumen, (ii) a plurality of solid drug tablets positioned in the drug reservoir lumen, and (iii) a retention frame positioned in the retention frame lumen, the retention frame comprising a shape memory material set in a coiled retention shape, wherein the device is elastically deformable between a relatively lower-profile shape to permit insertion of the device through the patient's urethra and a relatively higher-profile coiled shape for retention of the device within the patient's urinary bladder; and then
releasing solubilized drug from the device into the patient's urinary bladder,
wherein the device comprise a drug reservoir tube that defines the drug reservoir lumen; and a retention frame tube that defines the retention frame lumen, the retention frame tube being longitudinally aligned with and coupled to the drug reservoir tube along their entire lengths, wherein the drug reservoir tube and the retention frame tube are each substantially cylindrical and together form a monolithic structure.

US Pat. No. 10,137,061

DENTAL FILLERS AND COMPOSITIONS INCLUDING PHOSPHATE SALTS

3M Innovative Properties ...

1. A dental composition comprising:a hardenable resin comprising water, wherein the hardenable resin is polymerizable and/or crosslinkable; and
a phosphate salt of the formula:

where x=2-4;
each R is independently H or P(O)(O?)2(M+n)2/n, with the proviso that at least one R group is P(O)(O?)2(M+2n)2/n and at least one R group is H; and
M is a metal of valence n,
wherein the phosphate salt is dissolved in the hardenable resin of the dental composition.

US Pat. No. 10,137,060

INFANT PACIFIER WITH IMPROVED RETENTION

1. A pacifier, comprising:a nipple portion comprising a bulb and a stem, the bulb extending proximally from the stem;
a shield, the nipple portion extending proximally from the shield, the shield extending radially outwardly about the circumference of the stem and having an outer edge comprising top, side and bottom edge portions, the entire shield outer edge being distal of the bulb;
a retainer portion spaced from the nipple portion, the retainer portion extending proximally and terminating at a contact pad; and
an extension extending between the nipple portion and the retainer portion, at least part of the extension being distal of the nipple portion and attached to the shield, the extension depending below the bottom edge portion of the shield, the extension supporting the retainer portion so as to maintain the retainer portion at a position wherein the retainer portion extends proximally, generally parallel to and spaced from the stem;
wherein the retainer portion is biased toward the nipple portion; and
wherein no portion of the pacifier proximal of the shield extends higher than the top edge portion of the shield when the pacifier is held so that the stem extends horizontally with the top edge portion of the shield higher than the stem.

US Pat. No. 10,137,059

NURSING BOTTLE WITH INTEGRATED COLLAR AND NIPPLE FLANGE VENTING STRUCTURE

3. A single vented container for use for holding a liquid, and for dispensing of the same, said container consisting of a body portion, a neck portion, the neck portion having integral threads, a collar provided for the container, and having internal threads capable of engagement with the neck portion of said container, a nipple provided upon the upper neck portion of the bottle, said nipple having an upstanding dispensing portion, and an integral flange extending radially from the bottom of the nipple, said flange having a vertical aperture extending therethrough, communicating with the interior of the bottle, and said flange having an upper surface, and a flange passage provided upon the upper surface of the flange nipple, communicating with the flange vertical aperture, and extending radially to the perimeter edge of the nipple flange, and communicating with the space between the threads securing the collar to the neck of the bottle, said nipple flange having a lower surface, an integral sleeve provided upon the lower surface of the nipple flange, and said sleeve being in alignment with the vertical aperture through said flange, a vent tube securing with the integral sleeve upon the lower surface of said nipple flange, and said vent tube provided for securing with said integral sleeve for holding the vent tube into position when applied for venting with the single vented container during usage, wherein said container comprises a nursing bottle, and wherein said nipple is a nursing bottle nipple.

US Pat. No. 10,137,058

UNIT DOSE DISPENSING MECHANISMS

Omnicell, Inc., Mountain...

1. A dispensing mechanism, comprising:a connector for receiving electrical signals from a cabinet in which the dispensing mechanism is installed;
an actuator that operates in response to the electrical signals;
a non-circular sprocket driven by the actuator, wherein the teeth of the non-circular sprocket are not all the same distance from an axis of rotation of the non-circular sprocket;
a belt driven by the sprocket, the belt comprising a plurality of links, and the belt configured to circulate within a chamber when driven by the actuator;
a plurality of paddles integrally formed with the links of the belt for receiving between pairs of the paddles items to be dispensed, the paddles extending from the belt; and
a housing defining the chamber and defining an opening at the bottom of the chamber, such that a single item drops from between its respective paddles and through the opening when the segmented belt is incrementally advanced and the paddle supporting the item approaches a vertical orientation due to the advancement of the belt.

US Pat. No. 10,137,057

TABLET CASSETTE

YUYAMA MFG. CO., LTD., O...

1. A rotor for a tablet cassette rotatably disposed in a cassette body, the rotor comprising:a plurality of tablet guide grooves extending in a rotation axial direction so that the tablets contained in the cassette body are discharged through the tablet guide grooves, wherein:
first and second side surfaces of each of the plurality of tablet guide grooves are formed by first and second movable plates which are movable relative to one another in a circumferential direction of the rotor, the first movable plate defining a first adjustment hole and a second adjustment hole, the second movable plate defining a third adjustment hole and a fourth adjustment hole; and
a groove width adjustment mechanism configured to move the movable plates in the circumferential direction of the rotor relative to one another to adjust a width of each of the plurality of tablet guide grooves in response to a size of the tablet, the groove width adjustment mechanism including an operating member having a first adjustment pin, a second adjustment pin, and a base interconnecting the first and second adjustment pins, the first adjustment pin passing through the first and third adjustment holes, the second adjustment pin passing through the second and fourth adjustment holes.

US Pat. No. 10,137,056

DEVICE FOR SEXUAL STIMULATION

1. A device for sexual stimulation of a human body, said device comprising a phallus-shaped stimulation body having a thickness and/or a length that is variable in regions, wherein the stimulation body comprises a length adjustment element that is movable to lengthen and shorten the stimulation body in an axial direction in relation to a main body of the stimulation body, and has a hollow cylinder that is mounted on and displaceable on the main body, wherein the stimulation body is provided with permanent magnets to vary the length of the stimulation body, the permanent magnets being arrangeable in a starting position, in which the permanent magnets mutually attract, and in a lengthening position, in which the permanent magnets mutually repel, and the length adjustment element is movable on the main body by movement of the permanent magnets between the starting position and the lengthening position.

US Pat. No. 10,137,055

PORTABLE FITNESS ROLLER

1. A portable fitness roller comprising:an outer contact skin having an outer compressible surface configured for use as a fitness roller, wherein the outer contact skin includes a series of rigid axial stiffeners running parallel to a central roller axis and extending a length of the outer contact skin, adjacent axial stiffeners being joined together via joints parallel to the central roller axis so that the axial stiffeners and outer contact skin can be formed into a tubular expanded shape defining a cylindrical volume and the axial stiffeners may be released from the tubular expanded shape so as to convert to a collapsed shape, the fitness roller in the expanded shape having sufficient strength to support the weight of a person rolling thereon without collapse; and
a plurality of stiffening elements disposed within the outer contact skin so as to contact and radially support the outer contact skin in the tubular expanded shape and that are movable relative to each other to permit the outer contact skin to assume the collapsed shape by manually displacing two of the plurality of stiffening elements located at each longitudinal end of the support structure.

US Pat. No. 10,137,054

MASSAGE DEVICE EQUIPPED WITH INTERCHANGEABLE MASSAGE HEADS

SEB S.A., Ecully (FR)

1. Massage device (1) including:a body (2) which contains a drive mechanism (3),
at least one type of massage head (4, 5, 6, 7 and 8) which includes massage elements,
a transmission mechanism which allows the massage elements to be activated by the drive mechanism,
an installation mechanism (9) which is configured for the installation and removal of the at least one type of massage head with the body, characterized in that the device includes recognition means (146) of the type of massage head installed on the body and control mechanisms (161) for controlling said massage device based on the recognition of the type of massage head, wherein the massage device comprises a reduction gear installed on an output of a motor,
wherein the installation mechanism comprises a snapping mechanism comprising a blockage system with a notch and a release latch,
wherein the recognition means comprises: (i) mechanical sensors installed on the at least one type of massage head and the body, and are configured to transfer information to the control mechanisms based on the type of massage head installed on the body; or (ii) magnetic sensors installed on the at least one type of massage head and the body, and are configured to transfer information to the control mechanisms based on the type of massage head installed on the body, and
wherein the mechanical or magnetic sensors are formed in grooves of the body that receive protuberances of the at least one type of massage head such that the protuberances trigger the mechanical or magnetic sensors and are recognized based on binary code programmed into a command box.

US Pat. No. 10,137,053

MASSAGE APPARATUS

DAITO ELECTRIC MACHINE IN...

1. A massage apparatus comprising:a backrest for supporting user's back; and
a massager disposed inside the backrest for producing massage action on the user's back,
said backrest having its front side with a two-layer structure, and being provided with a warm-cool air supply section capable of feeding warm air or cool air into an interlayer region of said two-layer structure,
said massager being configured to move up and down along a direction of length of said backrest,
said warm-cool air supply section being located outside of a movement area of the massager,
said movement area of said massager having a shape of an elongated strip that extends in the length direction,
said warm-cool air supply section being disposed on at least a right side or a left side of said movement area,
said two-layer structure comprising a front cover body constituting a front face of said backrest and a back cover body disposed in a state of overlying a back side of the front cover body,
the interlayer region is configured to store warm air or cool air created between said front cover body and said back cover body,
said warm-cool air supply section being connected to the interlayer region and is configured to feed warm air or cool air into said interlayer region,
said warm-cool air supply section including a blower fan, a fan motor, and a heater, the blower fan delivering air to the heater to produce heated air and to feed the heated air into the interlayer region of the two-layer structure, and
when viewed from a lateral direction, the warm-cool air supply section, including the blower fan, the fan motor, and the heater, is located in overlapping relation with the movement area of the massager,
wherein the massage apparatus further comprises a cover plate being plate shaped and overlying a front face of the massager, the cover plate being provided with an opening at a location corresponding to the movement area of the massager,
wherein the warm-cool air supply section includes right and left warm-cool air supply sections being disposed on at least either of a right side and a left side of the opening on a rear face of the cover plate in a horizontal direction, with said opening lying in between the right and left warm-cool air supply sections,
wherein the back cover body is attached to the opening of said cover plate,
wherein the front cover body overlies the cover plate to cover an entire front side of the cover plate,
wherein the right and left warm-cool air supply sections are configured to feed warm air or cool air from a respective open hole of the cover plate, and
wherein the open holes of the right and left warm-cool air supply sections are located at a lower end side of the cover plate.

US Pat. No. 10,137,052

COMPRESSION DEVICE WITH WEAR AREA

KPR U.S., LLC, Mansfield...

1. A device for applying compression treatment to a part of a wearer's body, the device having an inner face for being placed adjacent to the part of the wearer's body in use and an outer face opposite the inner face, the device comprising:a pressure applicator to apply compression to the wearer's body part when the device is placed on the wearer's body part;
a plurality of patches of hook material on the inner face of the device; and
loop material mounted on the entirety of the outer face of the device and adapted for releasably connecting to at least one of said plurality of patches of hook material for use in holding the device on the wearer's body part, the loop material including a plurality of colored areas spaced apart from each other along a longitudinal axis of the device indicating areas of engagement for at least one of said plurality of patches of hook material, the colored areas having a different color from loop material immediately adjacent the colored areas, the colored areas and the loop material immediately adjacent the colored areas form a continuous loop material section.

US Pat. No. 10,137,051

SINGLE TUBE CRUTCH AND METHOD OF NESTING AND PACKAGING THE SAME

Medline Industries, Inc.,...

1. A crutch, comprising:a single tube support comprising an upper leg and a lower leg comprising a slip-resistant tip, the lower leg fully insertable into a first end of the upper leg such that only the slip-resistant tip is exposed;
an underarm support coupled to a second end of the upper leg opposite the first end;
a grip assembly configured to translate along the upper leg between a usage position and a stowed position, the grip assembly comprising an annular receiver and a grip extending distally from the annular receiver;
a plurality of grip assembly apertures disposed along the upper leg, each of which the grip assembly may align when in the usage position; and
a stowage aperture disposed along the upper leg, with which the grip assembly may align when in the stowed position.

US Pat. No. 10,137,050

GAIT DEVICE WITH A CRUTCH

ReWalk Robotics Ltd., Yo...

1. A system comprising:a motorized gait device for facilitating a gait of a person over a surface;
two crutches, separate from the motorized gait device and configured to be mechanically coupled to the motorized gait device via a limiter; and
a processing unit configured to set and/or maintain a limit on angular motion on the limiter,
the crutches being manipulable to move forward or backward through an angular range that is limited by the limiter, the two crutches being coupled to one another to prevent substantially different forward or backward motions of the two crutches, the crutches comprising a locomotion facilitator to enhance locomotion of the crutches over the surface and a mechanism to modify the locomotion of the crutches over the surface.

US Pat. No. 10,137,049

DRIVING MODULE, MOTION ASSISTANCE APPARATUS INCLUDING THE DRIVING MODULE, AND METHOD OF CONTROLLING THE MOTION ASSISTANCE APPARATUS

Samsung Electronics Co., ...

1. A driving module comprising:a driving source adapted to be on one side of a user, and configured to provide power;
a first decelerator including a first input terminal coupled to the driving source, and a first output terminal and a second output terminal configured to receive power from the first input terminal;
a second decelerator including a second input terminal coupled to the first output terminal, and a third output terminal and a fourth output terminal configured to receive power from the second input terminal; and
a third decelerator including a third input terminal coupled to the second output terminal, and a fifth output terminal and a sixth output terminal configured to receive power from the third input terminal,
wherein the first decelerator is coupled to the second decelerator such that the first output terminal transmits power to the second input terminal,
the first decelerator is coupled to the third decelerator such that the second output terminal transmits power to the third input terminal, and
the first decelerator is between the second decelerator and the third decelerator.

US Pat. No. 10,137,048

STRETCHING APPARATUS FOR STRETCHING THE BACK

1. A stretching appliance, comprising:a floor plate (9) having a mast (6, 8) upwardly disposed on said floor plate (9) and having an adjustable height;
a rest mounted on said mast and being configured for supporting a human body, said rest is pivotably mounted to said mast (6, 8) and is being configured to pivot about a horizontal axis (42);
shoulders restraining means adjustably mounted on a first end of said rest and being configured to hold shoulders of a human body laying on said rest;
feet restraining means adjustably mounted on a second end of said rest and being configured to hold feet of the human body laying on said rest; and
an adjusting mechanism configured for adjusting distance between said shoulder restraining means and feet restraining means by way of pivoting the rest about the horizontal axis.

US Pat. No. 10,137,047

AUTOMATED PILOTLESS AIR AMBULANCE

1. An automated pilotless air ambulance system comprising:an air vehicle (AV) having a fuselage, the fuselage having a stretcher mounted thereon for carrying a patient, the air vehicle configured to be dispatched to a point of injury of the patient and further configured to transport the patient to a medical treatment facility;
a plurality of air-lift motors coupled to the fuselage for vertically lifting the air vehicle, each air lift motor being coupled to a mounting arm such that the air lift motors are disposed substantially in the front and back of the fuselage, thereby enabling the stretcher to be transported with the patient thereon into and out of the AV, and wherein each mounting arm is securely coupled to the fuselage to form a low-profile configuration, whereby the patient is nested in the AV such that each air lift motor is disposed substantially on the same plane as the patient;
an automated life support and monitoring patient suite having a plurality of life support and monitoring devices and medical supplies; and
a bidirectional datalink coupled to the air vehicle, the datalink configured to execute the following functions:
receive and send signals to a patient's or first responder's mobile device or a networked device having geolocation capabilities, thereby enabling the air vehicle to obtain a geographic earth location of the patient;
receive and send signals to the patient's or first responder's mobile device for allowing the air vehicle to be autonomously dispatched when contacted by the patient's or the first responder's mobile device or the networked device;
receive and send signals to at least one medical health provider or physician who is using another air vehicle (AV) system to provide guidance to the first responder; and
receive and send signals to the at least one medical health provider or physician in order to allow the at least one medical health provider or physician to monitor the patient's vitals and to prepare the medical treatment facility for the patient's arrival.

US Pat. No. 10,137,046

DISPOSABLE BEDPAN WITH LID

1. A disposable bedpan with lid, comprising:A) a bedpan comprising a base and a sidewall having at least one lateral support, said bedpan further comprises a top ridge and a front ridge, said bedpan further comprises a front top cavity defined between said top ridge and said front ridge;
B) a cover comprising a cover base and a u-shaped cover base ridge, said u-shaped cover base ridge is inserted into said front top cavity when said cover mounts upon said bedpan, said cover is connected to said bedpan by a hinge; and
C) a lid comprising a lid panel, said lid is connected to said bedpan by a lid hinge, said lid further comprises at least one panel locking protrusion that secures upon said cover when in a closed configuration, said cover and said lid seal said bedpan to prevent waste from coming out when in said closed configuration, said lid panel comprising at least one lid ridge.

US Pat. No. 10,137,045

PATIENT REPOSITIONING SYSTEM

Hillenbrand Management Co...

1. A patient repositioning system comprising:a mattress having a head end and a foot end and an upper surface and opposing longitudinal sides;
a sheet residing on the upper surface;
a pulling device operatively connected to the sheet and adapted to pull the sheet toward the head end with a patient residing thereon, thereby to reposition the patient;
a housing holding the pulling device;
an arrestor operatively connected to the pulling device and adapted to normally hold the sheet in place so as to prevent movement of the sheet toward the foot end of the mattress, and operable to selectively enable the sheet to be repositioned, reversed, or removed from the housing; and
a hand held device operable to selectively cooperate with the housing so as to actuate the pulling device from outside the housing, thereby to enable the patient to be repositioned from outside the housing.

US Pat. No. 10,137,044

PATIENT SUPPORT APPARATUS WITH SENSOR ASSEMBLY

Hill-Rom Services, Inc., ...

1. A patient support system, comprising:a patient support device including an air fluidizable section, the air fluidizable section including a basin containing fluidization material for creating a two-phase support surface for patient support by distribution of pressurized fluid through the fluidization material, and
a sensor assembly configured to detect a temperature within the air fluidizable section, the sensor assembly comprising:
a housing defining an interior space, the housing being coupled to a wall of the air fluidizable section,
a processor, the processor being positioned within the interior space of the housing,
a thermal conductor, and
a thermal insulator.

US Pat. No. 10,137,043

TILT-TIP MOLDABLE TOTAL CARE BED

Utopix Medical, LLC, Fri...

1. A moldable mattress comprising:a casing comprising a bladder defining an inner volume and a top compliant surface over a top surface of the bladder, the compliant surface configured to conform to a shape of a displacing structure;
a plurality of beads within the inner volume; wherein:
the casing is configured so that the inner volume can be inflated and evacuated with a fluid medium, such that the casing is moldable when inflated, and maintains a resilient shape when an actuating volume of the fluid medium is evacuated;
the plurality of beads are distributed in the fluid medium within the inner volume;
in use, with the inner volume of the casing inflated the displacing structure disposed on the compliant surface causes a displacement of at least a portion of the fluid medium and at least a portion of the plurality of beads in the inner volume of the casing and the casing compresses the plurality of beads to maintain a shape of the displacement by the displacing structure when an actuating volume of the fluid medium is evacuated; and
wherein the casing in a plan view has a hemispheric egg-shape.

US Pat. No. 10,137,042

TRAVELLING APPARATUS

THE UNIVERSITY OF TOKYO, ...

1. A travelling apparatus comprising:a first wheel, the first wheel being a driving wheel;
a vehicle body;
a first linear motion actuator configured to be extendable and retractable and couple the first wheel to the vehicle body;
a second wheel configured to be disposed at a back of the first wheel;
a second linear motion actuator configured to be extendable and retractable and couple the second wheel to the vehicle body;
a third wheel configured to be disposed at a back of the second wheel;
a first link configured to couple the second wheel to the third wheel;
a second link configured to couple the first link to the vehicle body; and
an actuator configured to change an angle between the vehicle body and the second link,
wherein the second wheel and the third wheel are non-driven wheels.

US Pat. No. 10,137,041

HANDY TYPE ELECTRIC CARRIAGE

KUIANDA COMPANY LIMITED, ...

1. A handy type electric carriage, comprising:a vehicle body, comprising a main vehicle frame, two driving wheels individually pivoted to said main vehicle frame at two sides thereof, and two front wheel sets individually and correspondingly provided at two sides in front of said two driving wheels as well as pivoted to said main vehicle frame, wherein said two front wheel sets and said main vehicle frame are pivoted in a manner of quick-release structure; and
a footrest unit connected to said vehicle body, said footrest unit comprising a foot board connected to said main vehicle frame, and two first auxiliary wheels individually provided at left and right sides of said foot board.

US Pat. No. 10,137,040

ABSORBENT ARTICLES FORMING A THREE-DIMENSIONAL BASIN

1. An absorbent article having a wearer-facing side and a garment-facing side, and extending in a longitudinal direction and a transversal direction, the article comprising:a topsheet on the wearer-facing side for contact with a wearer's skin;
a backsheet on the garment-facing side;
an absorbent core between the topsheet and the backsheet, wherein the absorbent core comprises an absorbent material layer, the absorbent material layer comprising an absorbent material and further comprising a longitudinally-extending central portion, a first side portion disposed transversally outward of the central portion and a second side portion disposed transversally outward of the central portion on another side of the central portion;
wherein the absorbent core further comprises a first folding guide dividing the central portion and the first side portion, and a second folding guide dividing the central portion and the second side portion;
wherein the central portion and the side portions form a three-dimensional basin when the absorbent core is folded along the folding guides;
wherein the absorbent article further comprises:
at least one liquid management layer substantially free of superabsorbent polymer, the liquid management layer being at least partially disposed between the topsheet and the absorbent core; and wherein the liquid management layer comprises a liquid management layer's central portion, a first and second liquid management layer's side portions, and a first and second liquid management layer's folding guides between the liquid management layer's central portion and the first and second liquid management layer's side portions respectively, wherein the liquid management layer's folding guides are at least partially superposed with the folding guides of the absorbent core; and wherein each side portion comprises a plurality of winglets arranged in the longitudinal direction, each winglet having a proximal side relative to a folding guide and extending outward from this proximal side, wherein neighboring winglets are separated by a gap between their neighboring sides.

US Pat. No. 10,137,039

ABSORBENT CORES HAVING CHANNEL-FORMING AREAS AND C-WRAP SEALS

1. A absorbent core extending in a transversal direction and a longitudinal direction, the absorbent core having a front edge, a back edge and two longitudinally extending side edges, the absorbent core comprising:(a) a core wrap comprising a first substrate and a second substrate wherein each substrate comprises an inner surface and an outer surface;
(b) an absorbent material comprising a periphery defining an absorbent material deposition area, between the first substrate and the second substrate, the absorbent material deposition area encompassing one or more areas substantially free of absorbent material; and
(c) an auxiliary glue applied directly to the inner surface of the first substrate and defining an auxiliary glue application area;
wherein the auxiliary glue at least partially bonds the inner surface of the first substrate to the inner surface of the second substrate through the one or more areas substantially free of absorbent material, so that when the absorbent material swells, the core wrap forms channels in the areas substantially free of absorbent material that have a width from 2 mm to 20 mm;
wherein the auxiliary glue application area is smaller than the absorbent material deposition area and the first substrate and/or the second substrate comprises at least one outwardly extending flap which is folded around at least one of the front, back, or any of the side edges of the core, and the at least one flap is bonded to the external surface of the other substrate to form a C-wrap seal along the at least one edge of the absorbent core; and
wherein the channels do not extend to any edge of the absorbent material deposition area.

US Pat. No. 10,137,038

STERILE ADHESIVE BANDAGE CONTAINING A POCKET

1. An adhesive bandage comprising a base portion having at least one gauze portion adapted to contact a wound in a skin surface and an adhesive portion; the adhesive portion having an adhesive on a first surface of the base portion adapted to adhere to skin around three sides of and peripheral to the wound; the base portion defining a pocket adapted for storing the at least one gauze portion, wherein the pocket comprises a folded over flap of the base portion and a side opening of the pocket allowing inspection and replacement of the at least one gauze portion without having to remove the entire bandage.

US Pat. No. 10,137,037

REDUCED-PRESSURE, TUNNEL-WOUND DRESSINGS, SYSTEMS, AND METHODS

KCI Licensing, Inc., San...

1. A method to treat a tunnel wound or fistula, the method comprising:providing a dressing, wherein the dressing comprises:
a distal end, a proximal end, and a longitudinal profile between the distal end and the proximal end, wherein a length of the dressing between the distal end and the proximal end is greater than a width of the dressing,
a longitudinal core member formed from a closed-cell foam and configured to expand under reduced pressure, and
a first longitudinal concentric member formed from an open-cell foam, wherein the first longitudinal concentric member is concentrically disposed on a circumference of the longitudinal core member;
inserting the distal end of the dressing into the tunnel wound or the fistula such that the distal end is positioned proximate to a bottom of the tunnel wound or the fistula and the proximal end of the dressing is positioned proximate to an opening of the tunnel wound or the fistula, wherein a gap is formed between the dressing and an inner wall of the tunnel wound or the fistula;
delivering the reduced pressure to the dressing to expand the longitudinal core member and to cause an outer circumference of the dressing to contact the inner wall of the tunnel wound or the fistula, wherein the first longitudinal concentric member compresses upon contact with the inner wall of the tunnel wound or the fistula; and
removing the reduced pressure to retract the dressing away from the inner wall of the tunnel wound or the fistula.

US Pat. No. 10,137,036

UNDERWATER MASK

TABATA CO., LTD., Tokyo ...

1. An underwater mask having an up-down direction and a lateral direction, comprising: a mask body having opposing sides and which comprises a lens frame having a lens on a front; a skirt extending rearward from the lens frame; and a strap configured to be coupled to at least one of the opposing sides of the mask body through a buckle, the strap having a plurality of engaging teeth, the buckle comprising: a base; a strap adjuster body; a handling member; and a stopper, the base comprising: a second coupling portion configured to be coupled to a first coupling portion on the at least one of the opposing sides turnably in the lateral direction; a fitting hole; and a spring comprising a locking hook, the strap adjuster body comprising: a plurality of engaging teeth opposite the spring configured to sequentially engage with the locking hook; a fitting shaft configured to be fitted into the fitting hole turnably by a predetermined angle in a circumferential direction of the fitting shaft; a guide shaft configured to be wound by the strap; a slide guide groove extending in the up-down direction; and a pair of guide openings opposite to each other in the up-down direction, the handling member comprising: an approximately V-shaped spring; a slider configured to slide along the slide guide groove; a pair of sliding portions near the slider; and a finger pad outside each sliding portion of the pair of sliding-portions, the finger pads configured to be exposed from the guide openings of the strap adjuster body, the stopper comprising: a pawl configured to sequentially engage with the engaging teeth of the strap; and a sliding contact tapered protrusion near the pawl, the sliding contact tapered protrusion slidably disposed between the pair of sliding portions, wherein the stopper is configured to be held by the strap adjuster body swingably toward a direction opposite to the body.

US Pat. No. 10,137,035

ROUND POSTERIOR CAPSULOTOMY FOR THE OPACIFICATION OF A POSTERIOR CAPSULE AND LENS

1. A method of treating loss of visual quality and acuity from changes of a posterior capsule of an eye the method comprising:examining characteristics of a patient's eye after surgery for insertion of an intraocular lens;
determining that one or more of: opaque cells, fibrotic tissue, wrinkles in a posterior capsule, folds in the posterior capsule and fluid in a space between the inserted intraocular lens and the posterior capsule, has occurred:
determining a start point and an end point in three dimensional space on the posterior capsule of the patient's eye; and
performing a Generally Round Posterior Capsulotomy in a continuous manner, eliminating irregular borders and sharp converging cuts, while the intraocular lens remains inserted in the eye, wherein the Generally Round Posterior Capsulotomy is based upon the determined start point and end point and comprises a generally round shape that prevents an increase in diameter over time and prevents loss of vitreous in the patient's eye and the performing of the Generally Round Posterior Capsulotomy does not induce pressure changes inside the eye.

US Pat. No. 10,137,034

PRESSURE-SENSING VITRECTOMY SURGICAL SYSTEMS AND METHODS

Novartis AG, Basel (CH)

1. A system for providing irrigation into an eye of a patient during a medical procedure, the system comprising:an infusion line configured to place a fluid source in fluid communication with the eye of the patient, the infusion line including:
a flexible elongate member having a proximal end, a distal end, and a lumen extending therethrough from the proximal end to the distal end, the lumen being configured to pass irrigation fluid to the eye of the patient;
an engagement member at the distal end, the engagement member being more rigid than the flexible elongate member and being configured to enter into a vitreous chamber of the eye of the patient; and
at least three pressure sensors internally disposed in the infusion line and configured to measure one or more pressures within the infusion line during the medical procedure, wherein the at least three pressure sensors are arranged to detect a pressure differential associated with a flow impediment along the infusion line between two of the at least three pressure sensors, such that the flow impediment is locatable between the two pressure sensors associated with the flow impediment pressure differential.

US Pat. No. 10,137,033

TORSIONAL MODE NEEDLE FOR PHACOEMULSIFICATION

Moog Inc., Elma, NY (US)...

1. A phacoemulsification needle for attachment to an ultrasonic handpiece operable to drive the needle back-and-forth in opposite longitudinal directions of the needle at a longitudinal drive frequency and a longitudinal drive magnitude, the phacoemulsification needle comprising:a base adapted for removable attachment to the handpiece; and
an elongated shaft extending from the base along a longitudinal axis, the shaft terminating at a distal tip having a cutting edge;
the base and the shaft including an aspiration lumen passing therethrough;
the shaft further including a plurality of external grooves extending in a longitudinal direction of the shaft;
wherein the plurality of grooves have a configuration that converts oscillatory longitudinal drive motion applied at the base of the needle to torsional motion at the tip of the needle, the torsional motion having a fundamental torsional mode frequency and a torsional mode magnitude, wherein the torsional mode magnitude is greater than the longitudinal drive magnitude;
wherein the plurality of grooves are helical grooves extending in the longitudinal direction of the shaft; and
wherein i) the plurality of grooves consists of exactly six grooves each having a helical pitch less than or equal to 22.86 mm, or ii) each of the plurality of grooves has a depth in a range from 0.102 mm through 0.124 mm and an axial length of 7.62 mm or iii) each of the plurality of grooves has a depth in a range from 0.116 mm through 0.142 mm and an axial length of 10.16 mm, or iv) the plurality of grooves consists of exactly five grooves each having a depth in a range from 0.127 mm through 0.152 mm.

US Pat. No. 10,137,032

SLUSH GENERATION

42 TECHNOLOGY LIMITED, C...

1. An apparatus for generating, at a target ice/liquid ratio with a corresponding target temperature, a slush comprising a frozen and non-frozen liquid, the apparatus comprising:a flow path that recirculates the frozen and non-frozen liquid therethrough; and
a heat exchanger, forming part of the flow path, comprising a coolant conduit extending longitudinally through the heat exchanger and a freeze conduit extending longitudinally through the heat exchanger, wherein the coolant conduit and the freeze conduit share a contiguous boundary along their longitudinal length through the heat exchanger such that thermal energy is transferred between the freeze conduit and the coolant conduit to partially freeze the non-frozen liquid in the conduit loop to generate the slush at the target ice/liquid ratio;
wherein the freeze conduit is devoid of an ice scraper and the coolant conduit is configured for flow therethrough of coolant at a temperature below the target temperature, the apparatus being configured to vary the rate of coolant flow through the coolant conduit between a first rate and a second rate that is lower than the first rate.

US Pat. No. 10,137,030

SELF-TITRATABLE MANDIBULAR REPOSITIONING DEVICE

Sleep Science Partners, I...

1. A mandibular re-positioning device, comprising:a first component adapted to receive a user's top teeth and a second component adapted to receive the user's bottom teeth and an intermediate component adapted to fit between the upper component and the lower component and to couple the upper and lower components;
a first mechanism coupling together the upper component with the intermediate component;
the first mechanism coupling the upper and intermediate components in either of two states comprising an unlocked state or a locked state;
the unlocked state allowing the upper and intermediate components to slide, relative to each other, along a sagittal axis, thereby allowing the user's mandible to freely move in an anterior or posterior direction while the mandibular re-positioning device is positioned within the user's mouth;
the locked state bringing the first component into closer contact with the intermediate component, thereby preventing the two components from sliding, relative to each other, along the sagittal axis, thereby preventing any change in mandibular advancement while the mandibular re-positioning device is positioned within the user's mouth;
the first mechanism being able to transition from the unlocked state to the locked state through application of a force along a vertical axis, the force coming from the user biting down;
a second mechanism coupling together the intermediate component with the second component and adapted to allow movement of the user's mandible in a lateral direction while the mandibular re-positioning device is positioned within the user's mouth; and
the second mechanism including a groove along the lateral direction within the second component, the groove coupling to a rail or to a tab on the intermediate component that travels within the groove, the groove being curved within the second component to match a natural movement of the user's mandible.

US Pat. No. 10,137,029

ANTI-SNORING DEVICE

1. An anti-snoring device, comprising:a housing having a front side, a rear side, and at least one sidewall extending therebetween;
a speaker disposed on the front side of the housing;
a microphone disposed on the front side of the housing;
wherein the speaker and microphone are disposed on the front side such that the speaker and microphone are facing a same direction;
a memory disposed within the housing;
wherein the memory is configured to store a plurality of audio files thereon;
a microprocessor operably connected to the memory;
a logic stored in the memory that, when executed by the microprocessor, causes the anti-snoring device to perform a method, the method comprising:
receiving an audio signal detected by the microphone;
determining if the audio signal matches one of a first set of audio files representing the sound of human snoring within a pre-defined certainty;
selecting one of a second set of audio files stored on the memory; and
playing the selected audio file of the second set of audio files through the speaker at a volume between 40-50 dB;
a power source disposed within the housing, wherein the power source is configured to provide power to the microprocessor, the memory, the speaker, and the microphone.

US Pat. No. 10,137,028

EYEWEAR SYSTEM FOR SECURING LENS ON A USER'S NOSE AND DILATING USER'S NOSE

1. A device for coupling at least one eyewear lens to at least one nasal applique attachable to a user's nose which results in dilation of a nasal passageway, the device comprising:a base engageable with the at least one eyewear lens;
an adjustment shaft coupled to the base and extending longitudinally along a rotation axis, the adjustment shaft being rotatable relative to the base about the rotation axis;
a first pivot unit coupled to the base and pivotable relative to the base about a first pivot axis in response to rotation of the adjustment shaft about the rotation axis; and
a second pivot unit coupled to the base and pivotable relative to the base about a second pivot axis in response to rotation of the adjustment shaft about the rotation axis;
the first pivot unit and the second pivot unit being interactable with at least one nasal applique to magnetically couple the first pivot unit and the second pivot unit to the at least one nasal applique, the magnetic coupling between the first pivot unit and the second pivot unit and the at least one nasal applique imparting a dilating force on the user's nose to dilate the nasal passageway when the at least one nasal applique is attached to the user's nose.

US Pat. No. 10,137,027

NASAL APPLIQUE AND RELATED APPLICATOR FOR APPLYING APPLIQUE TO A NOSE OF A WEARER

1. An applicator for placing a pair of nasal appliques on opposing lateral regions of a nose of a user, the applicator comprising:a base;
a nose rest coupled to the base and adapted to rest adjacent the nose of the user;
a pair of stop members coupled to the base and arranged in generally opposed relation to each other; and
a pair of placement members coupled to the base, each placement member including an arm coupled to the base and a pad coupled to the arm, each placement member being engageable with a respective one of the pair of nasal appliques, each placement member being selectively transitional between a first position and a second position, when each placement member is in its first position, the placement member is positioned adjacent the respective one of the pair of stop members and when each placement member is in its second position, the placement member is moved away from the respective one of the pair of stop members for placing the respective one of the pair of nasal appliques on the nose of the user.

US Pat. No. 10,137,026

WATER RESISTANT BANDAGE

BSN MEDICAL, INC., Charl...

1. A knitted bandage, consisting of:an inner face adapted to be positioned contacting skin and an outer face adapted to be positioned apart from the skin;
nylon monofilament yarns knitted into only the inner face and having a maximum diameter of 0.1 mm;
polyproylene monofilament yarns knitted into only the outer face and having a maximum diameter of 0.1 mm; and
elastic yarns knitted or laid in with wales of the knitted bandage to impart elasticity in the knitted bandage;
wherein the knitted bandage has a moisture vapor transmission rate of at least 500 g/m2 per 24 hours.

US Pat. No. 10,137,025

DEVICE AND METHOD FOR ELECTRIC STIMULATION OF MUSCLES INVOLVED IN HUMAN PHYSIOLOGICAL GAIT PATTERN AND BRACE TO SUPPORT AN ANATOMICAL JOINT WITH SUCH DEVICE

EVOMOTION GMBH, Luenebur...

5. A device for electrical stimulation of muscles involved in the physiological gait of a human, comprising: an element for electrical muscle stimulation; a sensor to detect information relevant to the muscle stimulation, wherein the sensor comprises a single gyroscope constructed to detect information including an angular speed ? and a swing direction in an extension direction and flexion direction of an anatomical lower leg of the human; an evaluation unit including a microprocessor to evaluate the information detected by the gyroscope and to determine a defined switching time for the muscle stimulation on the basis of the angular speed ? and the swing direction, and to transmit the determined switching time; and a control and regulation unit to trigger muscle stimulation by said element in response to receipt of the determined switching time.

US Pat. No. 10,137,024

APPARATUS, SYSTEM, AND METHOD FOR CONTROLLING MOVEMENT OF AN ORTHOPEDIC JOINT PROSTHESIS IN A MAMMALIAN SUBJECT

Elwha LLC, Bellevue, WA ...

1. A method for preventing dislocation of an orthopedic joint prosthesis in a mammalian subject comprising:providing an orthopedic brace external to the subject's body and including a first member and a second member, wherein the first member is configured to control movement of a first component of an internal orthopedic joint prosthesis and the second member is configured to control movement of a second component of the internal orthopedic joint prosthesis in the subject;
detecting one or more alignment orientations of the first component relative to the second component by one or more sensors in proximity to the first component and the second component of the internal orthopedic joint prosthesis, wherein the one or more sensors contact the internal orthopedic joint prosthesis;
communicating the one or more alignment orientations from the one or more sensors to one or more controllers; and
adjusting an alignment of the first component relative to the second component of the internal orthopedic joint prosthesis in response to a signal from the one or more controllers in operation with the first member and the second member of the orthopedic brace external to the subject's body.

US Pat. No. 10,137,023

COLONNADE (TM) EXPANDABLE INTRAGASTRIC FOOD FLOW LUMEN DEVICE

Medibotics LLC, St. Paul...

1. An implantable expandable intragastric device for reducing food consumption and/or absorption comprising:a plurality of longitudinal expandable members, wherein these expandable members are configured to be inserted into and expanded within a person's stomach, wherein these expandable members are expanded by being filled with one or more flowable substances selected from the group consisting of a gas, a liquid, a gel, and a foam, wherein each expandable member has a proximal surface which is configured to be closer to the gastroesophageal junction, wherein each expandable member has a distal surface which is configured to be closer to the pylorus, and wherein each expandable member has a central axis which spans from its proximal surface to its distal surface, wherein the expandable members have lateral cross sections that are shaped like keystones or rounded trapezoids, and wherein first portions of walls of the expandable members that are closer to a food flow lumen are less elastic than second portions of the walls of the expandable members that are farther from the food flow lumen;
the food flow lumen, wherein this food flow lumen has a proximal opening which is configured to be closer to the gastroesophageal junction, wherein this food flow lumen has a distal opening which is configured to be closer to the pylorus, wherein food flows into the proximal opening and out of the distal opening, wherein this food flow lumen has a central axis which spans from its proximal opening to its distal opening, wherein there is at least one plane of this device which is intersected by the central axis of the food flow lumen and the central axes of the expandable members, wherein the points where the central axes of the expandable members intersect this plane can be geometrically connected to form a polygon, wherein the point where the central axis of the food flow lumen intersects this plane is located inside this polygon, and wherein the expandable members are arranged symmetrically around the food flow lumen in a first cross-sectional plane and in a second cross-sectional plane, but are arranged asymmetrically around the food flow lumen in a third cross-sectional plane which is in between the first and second cross-sectional planes.

US Pat. No. 10,137,022

IMPLANTATION DEVICE WITH HANDLE AND METHOD OF USE THEREOF

QUALIMED INNOVATIVE MEDIZ...

1. An instrument for deploying an implantable medical device in a body lumen, the device comprising:a base member comprising a base handle;
a deployment extension having a distal end and a proximate end, the proximate end is connected to the base handle;
a first tubular member that fits over the deployment extension and is longitudinally slidable over the deployment extension, the first tubular member comprising: a first tubular body with a distal end and a proximate end, and a first handle for controlling movement of the first tubular member; and
a second tubular member that fits over the first tubular member and is longitudinally slidable over the first tubular member, the second tubular member comprising: a second tubular body with a distal end and a proximate end, and a second handle for controlling movement of the second tubular member,
wherein the first handle is located between the base handle and the second handle and wherein the distal ends of the deployment extension, the first tubular body, and the second tubular body are adapted to deploy an implantable medical device, and
wherein the distal ends in each of the deployment extension, the first tubular body and the second tubular body comprises a screw, luer or hub that is configured to facilitate removable attachment of a catheter to the distal ends in each of the deployment extension, the first tubular body and the second tubular body.

US Pat. No. 10,137,021

METHOD AND APPARATUS FOR CONTROLLING THE DEPLOYMENT OF A STENT

VASCUTEK LIMITED, Renfre...

1. A delivery apparatus, the apparatus comprising:a delivery shaft with a tubular prosthesis mounted on a proximal end thereof for insertion into a lumen and a distal end remote from the proximal end, the prosthesis comprising a sleeve and at least one discrete saddle-shaped ring stent with opposing peaks and opposing valleys positioned between the peaks, the at least one discrete saddle-shaped ring stent is attached to the sleeve to maintain the patency of the sleeve after deployment of the prosthesis;
a retractable sleeve adapted to contain the tubular prosthesis mounted on the delivery shaft;
a control handle adjacent the distal end of the delivery shaft;
at least one stent peak control wire extending from the control handle and directly attached to at least one peak of the opposing peaks at an at least one peak connection point;
at least one peak controller at the control handle adapted to control the position of the at least one stent peak control wire to selectively open the at least one peak from a collapsed state and collapse the at least one peak from an open state;
at least one stent valley control wire extending from the control handle and directly attached to at least one valley of the opposing valleys at an at least one valley connection point; and
at least one valley controller at the control handle adapted to control the position of the at least one stent valley control wire to selectively open the at least one valley from a collapsed state and collapse the at least one valley from an open state.

US Pat. No. 10,137,020

TWO PRONGED HANDLE

Cook Medical Technologies...

1. A delivery system comprising:a catheter having a proximal end and a distal end and an outermost surface extending there between, wherein the distal end comprises a deployable prosthesis;
a sheath slidably disposed about the outermost surface of the catheter; anda bifurcated gripping member disposed on the proximal end of the catheter,wherein the gripping member comprises a first stationary gripping prong and a second stationary prong, the first stationary gripping prong and the second stationary prong connected by a connection member,
and
wherein the first gripping prong comprises a handle configured to be grasped by a user and wherein a proximal end of the sheath is retracted proximally over, and generally conforms to, the shape of an outermost surface of the second stationary prong.

US Pat. No. 10,137,019

MEDICAL INSTRUMENT, RING PROSTHESIS, STENT AND STENTED VALVE

DAIDALOS SOLUTIONS B.V., ...

1. A stent, comprising:a tubular element with an open grid structure which is radially expandable from a compressed condition to an expanded condition, and which has a proximal and distal end; and
a ring structure provided around the tubular element,
wherein the tubular element and ring structure are interconnected,
wherein the ring structure is a variable-diameter ring structure with distal and proximal flange feet,
wherein the ring structure has an axial direction and a radial direction disposed transverse to the axial direction,
wherein the ring structure is constructed from a series of elongated closed loops lying next to one another which, in each case, at the midpoint of the longitudinal sides of the loops, are attached laterally to one another via a junction to form the ring structure, in such a way that a) an imaginary center line through all junctions forms a closed ring and divides each loop into a distal flange foot of said distal flange feet and a proximal flange foot of said proximal flange feet, and b) the ring structure is expandable,
wherein the distal and proximal flange feet each have a fixed end arranged at the imaginary center line and a free end pointing away from the imaginary center line,
wherein the distal and proximal flange feet have a radial position, in which the free ends of the flange feet point in the radial direction,
wherein the distal and proximal flange feet have an extended position, in which the distal and proximal flange feet extend in the axial direction,
wherein the distal flange feet and the proximal flange feet lie in a longitudinal direction of the tubular element when the tubular element is in the compressed condition and the distal and proximal flange feet are in the extended position,
wherein the distal and proximal flange feet, when in the extended position, are under a pre-tension, which, upon release, bends the distal and proximal flange feet from the extended position to the radial position,
wherein, in the extended position, the free ends of the distal flange feet point in the distal direction whilst the free ends of the proximal flange feet point in the proximal direction such that, after the distal and proximal flange feet have bent from the extended position to the radial position, the distal and proximal flange feet interact to clamp surrounding tissue between the distal and proximal flange feet, and
wherein the distal flange feet, at the fixed ends of the distal flange feet, have a concave-curved part including a hollow side facing toward the proximal flange feet, and in the hollow side of the concave-curved part, a filling is provided that is configured to increase a clamping force with which the distal and proximal flange feet clamp the tissue in situ when the distal and proximal flange feet are in the radial position.

US Pat. No. 10,137,018

ENDOVASCULAR ROUTER DEVICE AND METHOD

1. A router device for repairing a tubular vessel of a patient, where the tubular vessel is joined to at least one branch vessel, the router device comprising:a) a single wall and skeleton-free tubular graft having a proximal end and a distal end and at least one unobstructed fenestration formed therein before deployment in the patient, said fenestration adapted to receive and affix a stent, and a malleable annulus formed in a side of said tubular graft wherein the inner diameter of the annulus defines the fenestration and where the annulus inner diameter when deformed has a portion adjacent to the stent with a greater width than the outer diameter of the annulus and said fenestration sized and positioned to generally align with the branch vessel;
b) said distal end of the tubular graft having a diameter less than a diameter of the proximal end, and said single wall of the tubular graft including a tapered portion between the proximal and distal ends, wherein said fenestration is positioned within the tapered portion;
c) a cylindrical element including an outer surface that is adapted to be juxtaposed circumferentially to an interior surface of the tubular vessel so as to releasably affix the proximal end of the tubular graft to an interior surface of the tubular vessel so that the tubular graft may be repositioned within the tubular vessel of the patient; and
d) said distal end of the tubular graft configured so as to be suspended within an aneurysm formed in the tubular vessel when the proximal end of the tubular graft is affixed to the interior surface of the tubular vessel by the cylindrical element.

US Pat. No. 10,137,017

CRIMPER DEVICE

SUZHOU JIECHENG MEDICAL T...

1. A device for collapsing a stent frame, the device comprising:a stationary first component comprising a first grip section and a first guide section coupled to the first grip section, the first guide section comprising (i) a first central aperture having a first central axis and (ii) a plurality of first elongate guide slots extending in a radial direction from the first central aperture;
a rotatable second component comprising a second grip section and a second guide section, the second guide section comprising (i) a second central aperture having a second central axis coaxially aligned with the first central axis and (i) a plurality of driving structures extending about the second central aperture;
an alignment mechanism configured to maintain the second central axis coaxially aligned with the first central axis as the second guide section rotates relative to the first guide section; and
a plurality of compression members, each comprising a contact surface for engaging an expandable implant, each compression member being slidably positioned at least partially within a respective first elongate guide slot and slidably engaged with a respective driving structure for urging slidable movement of the compression members within the first elongate guide slots as the second guide section rotates relative to the first guide section, thereby moving the contact surfaces between expanded and collapsed positions upon rotation of the second component relative to the first component to increase or decrease a size of a compression aperture formed by the contact surfaces,
wherein each of the plurality of compression members comprises an axial engagement mechanism having an engagement arm extending radially therefrom and an engagement slot for receiving an adjacent engagement arm of an adjacent compression member, and wherein during movement to a closed configuration, adjacent engagement arms are configured to radially interconnect with adjacent engagement slots to restrict axial movement of the plurality of compression members with respect to each other.

US Pat. No. 10,137,016

HOLLOW DRUG-FILLED STENT AND METHOD OF FORMING HOLLOW DRUG-FILLED STENT

Medtronic Vascular, Inc.,...

1. A stent comprising:a wire formed into stent pattern, wherein the wire includes,
an outer member having an outer member outer surface and an outer member inner surface, the outer member inner surface defining an outer member inner dimension,
a radiopaque core member disposed within at least a portion of the outer member, the radiopaque core member having a radiopaque core member outer surface defining a radiopaque core member outer dimension, wherein the radiopaque core member outer dimension is smaller than the outer member inner dimension,
an annular lumen defined between the outer member inner surface and the radiopaque core member outer surface,
a biologically or pharmacologically active substance disposed in the annular lumen, and
at least one opening disposed through the outer member.

US Pat. No. 10,137,015

KNITTED STENT JACKETS

INSPIREMD LTD., Tel Aviv...

1. An assembly for opening a vessel lumen comprising:a radially expandable stent configured to open the vessel lumen, said radially expandable stent comprising a curved wall having a proximal portion, a distal portion, and a lumen connecting said proximal portion and said distal portion;
a knitted stent jacket comprising a tubular wall that substantially surrounds an exterior surface of said radially expandable stent; and
a plurality of buffering element cords having an external surface placed against an external surface of said knitted stent jacket, covering only a minor portion of a surface of the knitted stent jacket, in a manner which spaces the knitted stent jacket from an adjacent element of the assembly to buffer the knitted stent jacket from movement of the adjacent element, wherein each of the plurality of buffering element cords has a thickness greater than the knitted stent jacket and an entire length of each of the plurality of buffering element cords overlays the knitted stent jacket,
wherein said knitted stent jacket comprises at least three interconnected loops at its distal end, at least one first loop, at least one second loop and at least one third loop; andwherein the assembly comprises at least one separate retainer belt having at least one portion woven through said at least one first loop, past said at least one second loop and through said at least one third loop;said at least one second loop configured to create a run in said knitted stent jacket upon expansion of said radially expandable stent, wherein the distal end forms a terminal end of the knitted stent jacket and the at least three interconnected loops are arranged circumferentially at the terminal end.

US Pat. No. 10,137,014

STENT

NIPRO Corporation, Osaka...

1. A stent comprising a structure of a skeleton that is expandable and contractible in a radial direction so as to have a tubular shape, the stent being configured to be placed in a body lumen, whereinthe skeleton has a heteromorphic structure due to changes of a cross section shape thereof in a thickness direction,
the cross section shape of the skeleton has a triangle shape with three straight surfaces for which a width dimension becomes larger from an inner circumference surface thereof toward an outer circumference surface thereof, and
the skeleton is a metal skeleton comprising first and second annular parts that are formed integrally by electroforming using a different type of metal for each annular part and that have different rigidities.

US Pat. No. 10,137,013

ENDOLUMINAL DEVICE AND METHOD

Intact Vascular, Inc., W...

1. A self-expanding intravascular implant comprising:a proximal sinusoidal ring forming a proximal end of the self-expanding intravascular implant, the proximal sinusoidal ring comprising:
a plurality of proximal ring struts, each proximal ring strut of the plurality of proximal ring struts having a proximal end and a distal end;
a plurality of proximal ring proximal apices, wherein each proximal ring proximal apex of the plurality of proximal ring proximal apices connects two proximal ends of two proximal ring struts of the plurality of proximal ring struts; and
a plurality of proximal ring distal apices, wherein each proximal ring distal apex of the plurality of proximal distal apices connects two distal ends of two proximal ring struts of the plurality of proximal ring struts;
a distal sinusoidal ring forming a distal end of the self-expanding intravascular implant, the distal sinusoidal ring comprising:
a plurality of distal ring struts, each distal ring strut of the plurality of distal ring struts having a proximal end and a distal end;
a plurality of distal ring distal apices, wherein each distal ring distal apex of the plurality of distal ring distal apices connects two distal ends of two distal ring struts of the plurality of distal ring struts; and
a plurality of proximal ring distal apices, wherein each distal ring proximal apex of the plurality of proximal ring distal apices connects two proximal ends of two distal ring struts of the plurality of distal ring struts;
a plurality of bridge members, each bridge member of the plurality of bridge members comprising a proximal end, a distal end, and a bridge midpoint, wherein the proximal end of each bridge member of the plurality of bridge members is connected to the proximal sinusoidal ring and the distal end of each bridge member of the plurality of bridge members is connected to the distal sinusoidal ring;
a plurality of anchors, the plurality of anchors being located on the plurality of bridge members;
wherein an outer surface of the proximal sinusoidal ring, an outer surface of the distal sinusoidal ring, an outer surface of each bridge member of the plurality of bridge members, and an outer surface of each anchor of the plurality of anchors forms a generally cylindrical shape when the self-expanding intravascular implant is in an unconstrained state, wherein the plurality of anchors remain in-plane when the self-expanding intravascular implant is in a generally cylindrical configuration, and wherein the plurality of anchors is configured to project out of plane when the self-expanding intravascular implant is forced into a non-round configuration.

US Pat. No. 10,137,012

ANTI-THROMBOGENIC MEDICAL DEVICES AND METHODS

COVIDIEN LP, Mansfield, ...

1. A method comprising:forming an expandable tubular body comprising a plurality of braided filaments, wherein the expandable tubular body is configured to be implanted in a blood vessel, the plurality of braided filaments comprising a first filament comprising platinum or platinum alloy and a second filament comprising cobalt-chromium alloy;
applying a first phosphorylcholine material directly on the platinum or platinum alloy of the first filament;
applying a silane material to the second filament comprising the cobalt-chromium alloy, wherein the silane material comprises a silane selected from the group consisting of 3-glycidoxypropyltrimethoxysilane, 2-(3,4-epoxycyclohexyl)ethyltriethoxysilane, 2-(3,4-epoxycyclohexyl)ethyl-trimethoxysilane, (3-glycidoxypropyl)trimethoxysilane, (3-glycidoxypropyl)triethoxysilane, 5,6-epoxyhexyltriethoxysilane, (3-glycidoxypropyl)methyldiethoxysilane, (3-glycidoxypropyl)methyldimethoxysilane, (3-glycidoxypropyl)dimethylethoxysilane, 3-isocyanatopropyltriethoxysilane, (isocyanatomethyl)methyldimethoxysilane, 3-isocyanatopropyltrimethoxysilane, tris(3-trimethoxysilylpropyl)isocyanurate, (3-triethoxysilylpropyl)-t-butylcarbamate, triethoxysilylpropylethylcarbamate, 3-thiocyanatopropyltriethoxysilane, and combinations thereof; and
applying a second phosphorylcholine material on the silane material on the second filament,
wherein the first and second phosphorylcholine materials each define a thickness of less than 100 nanometers.

US Pat. No. 10,137,011

POWERED ANKLE-FOOT PROSTHESIS

Massachusetts Institute o...

1. An autonomous, wearable powered leg device, comprising:a) a controllable powered actuator including a motor being linkable to an ankle joint to thereby impart torque about the ankle joint;
b) a controller that includes an electromyographic processing unit linked to the controllable powered actuator;
c) at least one electromyographic sensor coupled to the electromyographic processing unit and connectable to limb muscles of an individual wearing the device, whereby electromyographic signals measured from the limb muscles are transmitted to the electromyographic processing unit and thereby modulate control commands from the controller; and
d) a plurality of servo controllers, at least one of the servo controllers linking the electromyographic processing unit to the controllable powered actuator, whereby the individual wearing the device can modulate the controller to adjust between the plurality of the servo controllers, wherein the servo controllers include:
i) a torque controller that provides an offset torque during powered plantar flexion push-off of the powered leg device;
ii) an impedance controller that modulates at least one of joint stiffness and damping of the powered leg device during a stance phase of a gait of the individual; and
iii) a position controller that controls foot position of the powered leg device during a swing phase of the gait of the individual.

US Pat. No. 10,137,010

COORDINATING OPERATION OF MULTIPLE LOWER LIMB DEVICES

VANDERBILT UNIVERSITY, N...

1. A method for operating an autonomous powered leg prosthesis for a lower limb of a body having at least one powered joint, at least one sensor for collecting real-time sensor information for the autonomous powered leg prosthesis, and a communications device, the method comprising:generating, via a first control system of the autonomous leg prosthesis, first control data for the communications device to establish a communications link with a second leg prosthesis associated with another lower limb of the body contralateral to the lower limb and having a second control system operating independently of the first control system;
receiving, at the first control system over the communications link, remote data for the second leg prosthesis, the remote data comprising state information for a second finite state model used by the second control system for operating the second leg prosthesis;
generating, via the first control system, second control data for transitioning the autonomous leg prosthesis from a current state in a first finite state model for operating the autonomous powered leg prosthesis to a different state in the first finite state model,
wherein the different state is selected based on the real-time sensor information and the remote data, wherein at least one state in the first finite state model is configured for causing the at least one powered joint to deliver net power, wherein the second control data further comprises instructions to transition the autonomous leg prosthesis to the at least one state only if the state data in the remote data indicates that the second leg prosthesis is in a weight bearing state.

US Pat. No. 10,137,009

EXPANDABLE INTERVERTEBRAL FUSION DEVICES AND METHODS OF INSTALLATION THEREOF

Globus Medical, Inc., Au...

1. An expandable fusion system comprising an expandable spinal implant having a distal end configured to lead into a space between adjacent vertebral bodies and a proximal end configured to trail the distal end, comprising:a body member comprising a first end section, a second end section, and a cavity therebetween, the first end section comprising a first bore and the second end section comprising a second bore;
a driving member, disposed on the distal end of the expandable spinal implant, the driving member comprising a tapered section configured to aid insertion of the expandable implant into the space between the intervertebral bodies;
a first endplate configured to engage the body member and the driving member;
a second endplate configured to engage the body member and the driving member; and
an actuator assembly comprising an actuation screw, the actuation screw comprising a head and a threaded body, wherein the head is configured to be completely contained between the first endplate and the second endplate,
wherein the driving member comprises a threaded bore extending longitudinally therethrough.

US Pat. No. 10,137,008

SURGICAL INSTRUMENT AND METHOD OF POSITIONING AN ACETABULAR PROSTHETIC COMPONENT

DEPUY IRELAND UNLIMITED C...

1. An orthopaedic surgical instrument for positioning an acetabular prosthetic component in a patient's surgically-prepared acetabulum, the instrument comprising:a base including a plurality of mounting legs configured to engage the patient's pelvis,
a first linkage pivotally coupled to the base, and
a locking mechanism operable to lock the first linkage in position relative to the base,
wherein the first linkage includes an indicator operable to provide an indication of a position of the instrument, and the instrument further comprises a second linkage removably coupled to the first linkage, the second linkage having an alignment axis corresponding to a desired abduction angle and a desired anteversion angle of the acetabular axis of the acetabular prosthetic component.

US Pat. No. 10,137,007

GEARED CAM EXPANDABLE INTERBODY IMPLANT AND METHOD OF IMPLANTING SAME

Warsaw Orthopedic, Inc., ...

1. An expandable spinal implant comprising:a proximal end and a distal end defining a mid-longitudinal axis therebetween the expandable spinal implant being configured for insertion into a patient's disc space between an upper vertebral body and a lower vertebral body, and the expandable spinal implant being expandable between a collapsed position, a fully expanded position, and at least one partially expanded position between the collapsed position and the fully expanded position;
an upper endplate, the upper endplate including a proximal end, a distal end, an outer surface, at least one side surface, and an inner surface, a portion of the inner surface including an upper rack portion, the upper rack portion including at least one downwardly-projecting tooth intermediate the proximal end and the distal end of the upper endplate, and at least one distal-most downwardly-projecting tooth proximate the distal end of the upper endplate;
a lower endplate, the lower endplate including a proximal end, a distal end, an outer surface, at least one side surface, and an inner surface, a portion of the inner surface including a lower rack portion, the lower rack portion including at least one upwardly-projecting tooth intermediate the proximal end and the distal end of the lower endplate, and at least one distal-most upwardly-projecting tooth proximate the distal end of the lower endplate, the proximal end of the lower endplate being pivotally connected to the proximal end of the upper endplate;
a chassis portion mounted within the implant between the upper endplate and the lower endplate, the chassis portion having a proximal end and a distal end, the proximal end having an opening defined therein, at least one depression defined therein proximate the opening, a first set of inner threads defined in the opening, and a second set of inner threads defined intermediate the proximal end and the distal end of the chassis portion;
a yoke movably mounted with respect to the chassis portion, the yoke having a proximal end and a distal end, and being defined by first and second substantially parallel spaced apart walls, each of the first and second spaced apart walls having a proximal end and a distal end;
a rotating portion rotatably mounted within the chassis portion, the rotating portion having an outer surface, a proximal end and a distal end, the proximal end having an opening defined therein, the distal end being positioned proximate the distal end of the yoke, and threads defined on at least a portion of the outer surface, the threads being engageable with the second set of inner threads in the chassis portion;
at least one first spur gear rotatably mounted to at least one of the distal ends of at least one of the first and second spaced apart walls of the yoke, the at least one first spur gear having at least one projecting first spur gear tooth configured to movably engage with the downwardly-depending teeth on the upper rack portion;
at least one second spur gear rotatably mounted to at least one of the distal ends of at least one of the first and second spaced apart walls of the yoke, the at least one second spur gear having at least one projecting second spur gear tooth configured to engage with the upwardly-projecting teeth on the lower rack portion; and
at least one spike pivotally attached to at least one of the first and second spaced apart walls of the yoke;
wherein the rotating portion is further configured to translate rotational motion thereof to linear motion of the yoke, the yoke translating the linear motion to rotational motion of at least the at least one first spur gear, thereby rotating the at least one first spur gear with respect to the yoke;
wherein the rotation of the at least one first spur gear with respect to the yoke defines a first linear walking motion of the at least one projecting first spur gear tooth along the downwardly-depending upper rack gear teeth toward the distal end of the implant, thereby pivoting the upper endplate to the at least one partially expanded position; and
wherein the linear motion of the yoke is translated to pivotal motion of the at least one spike from a collapsed position, to a fully deployed position transverse to the mid-longitudinal axis.

US Pat. No. 10,137,006

GEARED CAM EXPANDABLE INTERBODY IMPLANT AND METHOD OF IMPLANTING SAME

Warsaw Orthopedic, Inc., ...

1. An expandable spinal implant comprising:a proximal end and a distal end defining a mid-longitudinal axis therebetween, the expandable spinal implant being configured for insertion into a patient's disc space between an upper vertebral body and a lower vertebral body, and the expandable spinal implant being expandable between a collapsed position, a fully expanded position, and at least one partially expanded position between the collapsed position and the fully expanded position;
an upper endplate, the upper endplate including a proximal end, a distal end, an outer surface, at least one side surface, and an inner surface, a portion of the inner surface including an upper rack portion, the upper rack portion including at least one downwardly-projecting tooth intermediate the proximal end and the distal end of the upper endplate, and at least one distal-most downwardly-projecting tooth proximate the distal end of the upper endplate;
a lower endplate, the lower endplate including a proximal end, a distal end, an outer surface, at least one side surface, and an inner surface, a portion of the inner surface including a lower rack portion, the lower rack portion including at least one upwardly-projecting tooth intermediate the proximal end and the distal end of the lower endplate, and at least one distal-most upwardly-projecting tooth proximate the distal end of the lower endplate, the proximal end of the lower endplate being pivotally connected to the proximal end of the upper endplate;
a chassis portion mounted within the implant between the upper endplate and the lower endplate, the chassis portion having a proximal end and a distal end, the proximal end having an opening defined therein, at least one depression defined therein proximate the opening, a first set of inner threads defined in the opening, and a second set of inner threads defined intermediate the proximal end and the distal end of the chassis portion;
a yoke movably mounted with respect to the chassis portion, the yoke having a proximal end and a distal end, and being defined by first and second substantially parallel spaced apart walls, each of the first and second spaced apart walls having a proximal end and a distal end;
a rotating portion rotatably mounted within the chassis portion, the rotating portion having an outer surface, a proximal end and a distal end, the proximal end having an opening defined therein, the distal end being positioned proximate the distal end of the yoke, and threads defined on at least a portion of the outer surface, the threads being engageable with the second set of inner threads in the chassis portion;
at least one first spur gear rotatably mounted to at least one of the distal ends of at least one of the first and second spaced apart walls of the yoke, the at least one first spur gear having at least one projecting first spur gear tooth configured to movably engage with the downwardly-depending teeth on the upper rack portion; and
at least one second spur gear rotatably mounted to at least one of the distal ends of at least one of the first and second spaced apart walls of the yoke, the at least one second spur gear having at least one projecting second spur gear tooth configured to engage with the upwardly-projecting teeth on the lower rack portion;
wherein the rotating portion is further configured to translate rotational motion thereof to linear motion of the yoke, the yoke translating the linear motion to rotational motion of at least the at least one first spur gear, thereby rotating the at least one first spur gear with respect to the yoke; and
wherein the rotation of the at least one first spur gear with respect to the yoke defines a first linear walking motion of the at least one projecting first spur gear tooth along the downwardly-depending upper rack gear teeth toward the distal end of the implant, thereby pivoting the upper endplate to the at least one partially expanded position.

US Pat. No. 10,137,005

DEVICE AND METHOD FOR DEPLOYMENT OF AN ANCHORING DEVICE FOR INTERVERTEBRAL SPINAL FUSION

Globus Medical, Inc., Au...

1. An intervertebral fusion device comprising:a spacer adapted to be implanted between an upper vertebral body and a lower vertebral body;
a first anchor and a second anchor positioned within the spacer; and
an actuation screw positioned within the spacer and adapted to engage with the first anchor and the second anchor,
wherein when the actuation screw is actuated in a first direction, the first anchor moves to engage the upper vertebral body and the second anchor moves to engage the lower vertebral body, wherein the first anchor and the second anchor are configured to be moved simultaneously, and
wherein each of the first and second anchors includes a first side and a second side opposite the first side, the second side including a plurality of linear cuts configured to engage with the actuation screw.

US Pat. No. 10,137,004

INSERTION TOOLS AND METHODS FOR MINIMALLY INVASIVE SPINAL FUSION CAGE

Vivonics, Inc., Bedford,...

1. An intervertebral support insertion tool system comprising:a tube having a distal open end for insertion in a patient proximate vertebrae and a proximal open end;
a distal intervertebral support;
a shaft received in the tube proximal open end and having an interface for engaging the distal intervertebral support loaded inside the tube; and
a housing supporting the tube and shaft with a first drive mechanism to advance the shaft in the tube and a second drive mechanism to rotate the shaft.

US Pat. No. 10,137,003

LOW PROFILE INTERVERTEBRAL IMPLANT

DePuy Synthes Products, I...

1. A low profile intervertebral implant sized and configured to be implanted between adjacent upper and lower vertebral bodies, the implant comprising:a spacer having a first insertion end, a second end opposite the first insertion end, an upper surface configured to contact the upper vertebral body when the implant is implanted, and a lower surface configured to contact the lower vertebral body when the implant is implanted;
a plate including a first surface and a second surface opposite the first surface, the second surface spaced from the first surface in a first direction, the plate configured to be coupled to the spacer such that the second surface of the plate faces the second end of the spacer, the plate including an upper plate surface configured to face the upper vertebral body when the implant is implanted, the plate including a lower plate surface configured to face the lower vertebral body when the implant is implanted, the plate defining a first through hole configured to receive a first bone screw, the plate further including a first arm that extends from the second surface in the first direction, the first arm including a first inner spacer contacting surface, the plate further including a second arm that extends from the second surface in the first direction, the second arm including a second inner spacer contacting surface spaced from the first inner spacer contacting surface along a second direction that is perpendicular to the first direction; and
a bone fixation element that extends away from the upper plate surface at a location spaced from the first surface in the first direction, the location spaced from the second surface in a direction opposite the first direction;
wherein the second surface, the first inner spacer contacting surface, and the second inner spacer contacting surface combine to define a void that is configured to receive a portion of the spacer, the void defining a first width measured from the first inner spacer contacting surface to the second inner spacer contacting surface along the second direction at a first position, the void defining a second width measured from the first inner spacer contacting surface to the second inner spacer contacting surface along the second direction at a second position, the first width is greater than the second width, and the second width is spaced from the first width in the first direction.

US Pat. No. 10,137,002

STANDALONE INTERBODY IMPLANTS

Globus Medical, Inc., Au...

1. An intervertebral implant for implantation in an intervertebral space between adjacent vertebrae, the implant comprising:a spacer having a superior surface, an inferior surface, a proximal end, and a distal end, wherein the superior surface and the inferior surface each have a contact area configured to engage adjacent vertebrae, the spacer defining an opening extending from the superior surface to the inferior surface of the spacer, and the spacer defining a cutout extending from the proximal end to the opening;
a plurality of inserts, each insert at least partially defining a fastener aperture sized and dimensioned for receiving a fastener; and
a plurality of fasteners, each fastener received in the fastener aperture of each insert for engaging one of the adjacent vertebrae,
wherein each insert is coupled to the spacer such that at least a portion of the insert is received in the cutout in the spacer wherein the superior surface and the inferior surface are configured with a roughened or porous surface, and
wherein the plurality of inserts are spaced from each other,
wherein each of the fastener apertures is positioned in an oblique angle so that the plurality of fasteners extend at an angle from a longitudinal axis of the spacer and configured to engage with one of the adjacent vertebrae,
wherein the spacer includes torsional stabilizers on the superior and inferior surfaces opposite the plurality of inserts.

US Pat. No. 10,137,001

EXPANDABLE FUSION DEVICE AND METHOD OF INSTALLATION THEREOF

Globus Medical, Inc., Au...

1. A surgical method comprising:creating an access path to an intervertebral disc space;
inserting an expandable implant into the disc space, wherein the expandable implant comprises:
a first endplate having a pair of first tongues;
a second endplate opposed to the first endplate, the second endplate having a pair of second tongues;
a central ramp positioned between the first endplate and the second endplate, wherein the central ramp comprises a first end and a second end, wherein the second end includes a first ramped portion configured to engage a portion of the first endplate and a second ramped portion configured to engage a portion of the second endplate, and a third ramped portion configured to engage a portion of the first endplate and a fourth ramped portion configured to engage a portion of the second endplate positioned between the first and second ends, wherein the central ramp has a longitudinal bore, and wherein the first ramped portion has a pair of first grooves, each of the first grooves sized to receive one of the first tongues, and wherein the second ramped portion has a pair of second grooves, each of the second grooves sized to receive one of the second tongues;
a driving ramp positioned between the first endplate and the second endplate, wherein the driving ramp comprises a first end and a second end, wherein the second end includes a first angled portion configured to engage a portion of the first endplate and a second angled portion configured to engage a portion of the second endplate, wherein the driving ramp has a non-threaded longitudinal through bore extending from the first end to the second end of the driving ramp, the longitudinal bore of the of the central ramp and the non-threaded longitudinal through bore of the driving ramp are coaxially aligned;
an actuator insertable through the driving ramp, wherein a portion of the actuator extends through the non-threaded longitudinal through bore of the driving ramp and the longitudinal bore of the central ramp, the actuator is disposed and remains within the non-threaded longitudinal bore, and the actuator is movable with respect to the central ramp and the driving ramp, and wherein the actuator is configured to translate the driving ramp such that the second end of the driving ramp is moved closer to the second end of the central ramp to thereby cause expansion of the first endplate and the second endplate;
wherein the first tongues and the second tongues are configured to move within corresponding first grooves and second grooves to expand and compress the expandable implant;
wherein the third ramped portion and the fourth ramped portions extend outwardly from a rod receiving extension of the central ramp; andintroducing bone graft material adjacent the expandable implant.

US Pat. No. 10,137,000

METHOD AND APPARATUS FOR PLACEMENT INTO IATROGENICALLY CREATED SKELETAL VOIDS

1. A method of placing an implant into an iatrogenically created skeletal void within an individual vertebral body, the method comprising:creating a void by removing at least a portion of the individual vertebral body while leaving superior and inferior endplates functionally intact, the void extending through the individual vertebral body from an anterior wall through a posterior wall; and
placing the implant within the void between the superior endplate and the inferior endplate of the individual vertebra such that the implant does not engage with adjacent vertebra thereby permitting the endplates to perform their function.

US Pat. No. 10,136,999

SURGICAL IMPLANT, AND ASSOCIATED INSTALLATION TOOL, SURGICAL KIT AND METHOD OF PRODUCTION

IN2BONES, Ecully (FR)

1. A surgical implant (1) for correcting the mutual positioning or orientation of the bones of a patient designed to be inserted between at least two bone bodies (2, 3) of said patient, said surgical implant (1) comprising:a main body (5) extending along a longitudinal axis (X-X?) between a proximal end (6) and a distal end (7) of said main body (5),
a plurality of fins (9), each fin (9) being provided with a junction edge (10) connecting said fin (9) to said main body (5), such that said fins (9) protrude from said main body (5) from the respective junction edge (10) thereof, which substantially extends in a junction plane (Pj) whose normal is formed by said longitudinal axis (X-X?),
the surgical implant (1) being characterized in that each fin (9) has a sufficient flexibility so that it can be deformed along a direction centripetal and/or parallel to the longitudinal axis (X-X?) under the action of at least one of the bone bodies (2, 3) when said surgical implant (1) is inserted between said bone bodies (2, 3),
each fin (9) being provided with a free edge (11) and each fin comprising a portion extending between the junction edge (10) and the free edge (11), each fin (9) having at least:
one portion of constant width (12) along which the free edge (11) and the junction edge (10) are separated by a first distance (d1) substantially constant along said portion of constant width (12) and,
one flat portion (13), along which the free edge (11) and the junction edge (10) are separated by a second distance (d2) lower than the first distance (d1).

US Pat. No. 10,136,998

REVISION TOTAL ANKLE IMPLANTS

Wright Medical Technology...

1. A revision implant, comprising:a body extending between a first planar surface and a second planar surface;
a head extending from the first planar surface of the body and configured to couple the revision implant to an additional component of a multi-component prosthesis;
at least one coupling mechanism configured to couple the body to a first bone, wherein the at least one coupling mechanism comprises one or more protrusions extending from the second planar surface of the body; and
a dome-shaped projection extending from the second planar surface and defining a first fastener hole configured to receive a fastener coupling an augment to the body, where the augment is configured to fill a void of the first bone;
wherein the head defines a second fastener hole configured to receive the fastener.

US Pat. No. 10,136,997

TIBIAL PROSTHESIS FOR TIBIA WITH VARUS RESECTION

Zimmer, Inc., Warsaw, IN...

1. A system for forming a tibial implant configured for attachment to a tibia in a knee arthroplasty, the system comprising:one or more baseplates having a lateral portion and a medial portion oriented relative to an anteroposterior axis, each of the lateral portion and the medial portion having a distal surface configured to interface with a resected proximal surface of a tibia;
a plurality of fixation members each of the plurality of fixation members being configured to couple to the baseplate and extend both distally and medially from the baseplate such that each fixation member of the plurality of fixation members is oriented at an acute angle relative to the distal surface of the medial portion, and wherein each of the plurality of fixation members is configured to differ from others of the plurality of fixation members such that the acute angle formed by each of the plurality of fixation members, when mounted to the baseplate, differs in degree.

US Pat. No. 10,136,996

IMPLANTABLE PROSTHESIS FOR REPLACING THE HUMAN KNEE JOINT

1. An implantable prosthesis for replacing a human knee joint, comprising:a femoral prosthetic element and a tibial prosthetic element which are articulated with one another by means of a joint device for the purpose of executing a knee bend, the tibial prosthetic element having a through-opening for the passage of a tool, a rod-like tibial shaft anchoring part or an intramedullary lengthening nail,
wherein the joint device is designed to form a guide channel for the passage of the tool, the rod-like tibial shaft anchoring part or the intramedullary lengthening nail from outside, which guide channel is in alignment with the through-opening and is in connection therewith when the tibial prosthetic element and the femoral prosthetic element are arranged at a predetermined angle relative to one another in a functional position corresponding to a knee bend, and
wherein the joint device comprises a joint head which is connected to the femoral prosthetic element and has an interior space in which a joint element connected to the tibial prosthetic element is rotatably guided for guiding the knee bend, a passage opening into the interior space being formed in the joint head and a through-bore being formed in the joint element, the passage and the through-bore being in alignment with one another in the functional position to form the guide channel.

US Pat. No. 10,136,995

METHOD OF FUSING A SACROILIAC JOINT WITH AN IMPLANT WITH STRUTS

JCBD, LLC, Fort Collins,...

1. A method of fusing a sacroiliac joint defined between a sacrum and an ilium, the method comprising:implanting a joint implant at the sacroiliac joint, the joint implant comprising:
a length extending between a proximal end and a distal end;
an exterior surface extending the length;
an interior surface opposite the exterior surface and extending the length, the interior surface defining an internal volume therein;
a wall thickness defined between the external surface and the interior surface;
a proximal opening extending into the internal volume;
a first wall section comprising a first plurality of struts arranged along the length and defining a first plurality of openings extending through the wall thickness; and
a second wall section comprising a second plurality of struts arranged along the length and defining a second plurality of opening extending through the wall thickness,
wherein the first and second plurality of struts are each arranged along lengths of the first and second wall sections, respectively, such that each opening of the first and second plurality of openings are generally polygonal in shape.

US Pat. No. 10,136,994

COMPOSITE INTERBODY DEVICE AND ASSOCIATED MANUFACTURING METHOD

SB Technologies, LLC, Pa...

1. A composite interbody device, comprising:a plastic core having a superior surface and an inferior surface;
a superior endplate and an inferior endplate, each of the superior and inferior endplates including:
(a) a bone interface side for interfacing with bone and having a plurality of pores permitting bone growth therein, and
(b) a core interface side, opposite the bone interface side, having a plurality of voids that accommodate material of the plastic core to couple the endplate to a respective one of the superior and inferior surfaces, the voids being non-porously isolated from the pores to prevent the material of the plastic core from entering the pores.

US Pat. No. 10,136,993

NATIVE VALVE REPAIR DEVICES AND PROCEDURES

Edwards Lifesciences Corp...

1. A valve repair system for repairing a native valve of a patient during a non-open heart procedure, the valve repair system comprising:a delivery device having at least one lumen;
a valve repair device configured to be delivered through the lumen of the delivery device, and configured to attach to a native valve of a patient, the valve repair device comprising:
a pair of paddles that are movable between an open position and a closed position;
wherein each paddle includes a main portion and first and second side portions that are integrally formed with the main portion and extend from the main portion and are configured to contour to the shape of the native valve;
wherein the pair of paddles are configured such that the first and second side portions flex away from the main portion upon being attached to the native valve of the patient; and
a pair of gripping members that are configured to attach to the native valve of the patient.

US Pat. No. 10,136,992

CUFF CONFIGURATIONS FOR PROSTHETIC HEART VALVE

St. Jude Medical, Cardiol...

1. A prosthetic heart valve comprising:a collapsible and expandable stent having a proximal end, a distal end, an annulus section adjacent the proximal end and an aortic section adjacent the distal end, the stent including a plurality of struts;
a collapsible and expandable valve assembly including a cuff and a plurality of leaflets, the cuff being folded over itself to form an inner layer and an outer layer, the cuff being coupled to selected ones of the plurality of struts and having microspheres disposed therein, the microspheres being capable of expanding upon contact with blood.

US Pat. No. 10,136,991

REPLACEMENT HEART VALVE IMPLANT

Boston Scientific Scimed ...

1. A replacement heart valve implant, comprising:a braided anchor member configured to actuate between an elongated delivery configuration and an expanded deployed configuration, the braided anchor member formed from a plurality of filaments;
a circumferential seal member disposed about a distal portion of the braided anchor member, the circumferential seal member including a reinforcing band disposed at a distal end thereof; and
a plurality of valve leaflets connected to the braided anchor member;
wherein the reinforcing band is secured to the braided anchor member adjacent a distal end of the braided anchor member by a plurality of lashings, wherein each lashing is attached to two individual filaments of the plurality of filaments.

US Pat. No. 10,136,990

PIGGYBACK INTRAOCULAR LENS THAT IMPROVES OVERALL VISION WHERE THERE IS A LOCAL LOSS OF RETINAL FUNCTION

AMO Groningen B.V., Gron...

1. An ophthalmic lens configured to improve vision for a patient's eye, the lens comprising:an optic with a first surface and a second surface opposite the first surface, the optic having an optical axis that intersects the first and the second surface, wherein the optic when disposed in an eye of a patient is configured to reduce optical errors together with a cornea and an existing lens in the eye of the patient due to at least one of astigmatism or coma for light incident at an oblique angle with respect to an optical axis of the eye of the patient and focused at a peripheral retinal location disposed at a distance from the fovea and at an eccentricity of about 1 degree to about 25 degrees with respect to the fovea in a horizontal or a vertical plane,
wherein the first surface or the second surface of the optic is configured as a higher order aspheric surface, an aspheric Zernike surface or a Biconic Zernike surface described by at least one of (i) aspheric coefficients having an order greater than or equal to 8, or (ii) at least six Zernike coefficients,
wherein a thickness of the optic along the optical axis of the optic is less than 1.0 mm,
wherein a refractive power provided by the optic is between ?5.0 Diopter and +5.0 Diopter, and
wherein an astigmatic power provided by the optic is between 0.5 Diopter and 6.0 Diopter.

US Pat. No. 10,136,988

APPARATUS AND PROCESS FOR DELIVERING A SILICONE PROSTHESIS INTO A SURGICAL POCKET

KELLER MEDICAL, INC., St...

1. An apparatus for inserting an implant into a surgical pocket comprising:a conical sleeve defining an interior cavity having a first terminus and a second terminus and an interconnecting main body, said first terminus having a larger diameter than said second terminus, said conical sleeve being tapered to a reduced diameter outlet of said second terminus, said conical sleeve further comprising a series of indicia for predetermined dimensions and a lubricant on an interior surface of said conical sleeve;
said interconnecting main body comprising a flexible, non-elastic sheath selected from a material consisting of fabric, plastic, Mylar®, nylon, and combinations thereof;
wherein when an implant is positioned within the interior cavity of said conical sleeve through said first terminus, said main body is adapted to be manually manipulated to apply a directional pressure to said implant, forcing the implant along the length of the conical sleeve and exiting through said second terminus into the surgical pocket.

US Pat. No. 10,136,987

DEVICES FOR FLUID FLOW THROUGH BODY PASSAGES

LimFlow GmbH, Dresden (D...

1. A device comprising:a longitudinal axis;
a first end portion having a terminal first end diameter, the first end portion having a first length along the longitudinal axis, the first end portion being self-expanding;
a second end portion having a second end diameter smaller than the terminal first end diameter, the second end portion being substantially cylindrical, the second end portion having a second length along the longitudinal axis, the second end portion being self-expanding;
an intermediate portion between the first end portion and the second end portion, the intermediate portion tapering between the first end portion and the second end portion, the intermediate portion having a third length along the longitudinal axis, the first end portion being frustoconical, the first end portion tapering between the terminal first end diameter and the intermediate portion; and
a graft material coupled to at least the intermediate portion, the device configured to provide fluid flow between a first passage in which the first end portion is anchored and a second passage in which the second end portion is anchored.