US Pat. No. 10,767,251

SPRAY MATERIAL, SPRAYED MEMBER AND MAKING METHOD

Shin-Etsu Chemical Co., L...

1. A spray material comprising composite particles comprising (A) particles of rare earth fluoride and (B) particles of at least one rare earth compound selected from rare earth oxide, rare earth hydroxide, and rare earth carbonate,wherein the particles (A) and the particles (B) are consolidated together,
wherein a crystal phase of the spray material comprises a first phase corresponding to the rare earth fluoride and a second phase corresponding to the at least one rare earth compound, and
wherein the crystal phase of the spray material does not contain a phase corresponding to rare earth oxyfluoride.

US Pat. No. 10,767,249

MAGNETIC POWDER AND PRODUCTION METHOD THEREOF, MAGNETIC CORE AND PRODUCTION METHOD THEREOF, COIL COMPONENT AND MOTOR

Murata Manufacturing Co.,...

1. A magnetic powder comprisinga principal component represented by a general formula Fea-eMe(Sib(B1-?C?)cPd)100-a,
wherein M is one or more selected from the group consisting of Ni and Co, e is 0 to 12.0, ? is 0, and b+c+d=1.00,
when representing as (a, b) the a and the b, (a, b) is within a region surrounded by A1 (71.0, 0.19), B1 (79.6, 0), C1 (80.0, 0), D1 (81.0, 0.17), E1 (81.0, 0.44), F1 (79.6, 0.78) and G1 (71.0, 0.38),
when representing as (a, c) the a and the c, (a, c) is within a region surrounded by A2 (71.0, 0.48), B2 (78.1, 0), C2 (79.6, 0), D2 (81.0, 0.18), E2 (81.0, 0.26), F2 (79.1, 0.75) and G2 (71.0, 0.72), and
when representing as (a, d) the a and the d, (a, d) is within a region surrounded by A3 (71.0, 0.08), B3 (71.9, 0), C3 (79.1, 0), D3 (81.0, 0.36), E3 (81.0, 0.62), F3 (77.2, 0.67) and G3 (71.0, 0.23).

US Pat. No. 10,767,247

ALUMINUM ALLOY MAGNETIC DISK SUBSTRATE AND METHOD FOR PRODUCING SAME

UACJ Corporation, Tokyo ...

1. An aluminum alloy magnetic disk substrate comprising: an aluminum alloy base material comprising an aluminum alloy containing 0.4 to 3.0 mass % of Fe, 0.1 to 3.0 mass % of Mn, 0.005 to 1.000 mass % of Cu, and 0.005 to 1.000 mass % of Zn, with a balance of Al and unavoidable impurities; and an electroless Ni—P plated layer formed on a surface of the aluminum alloy base material, wherein a maximum value (BLEI) of Fe emission intensity in a range of 50 to 84% of Al emission intensity in an interior of the aluminum alloy base material, at an interface between the electroless Ni—P plated layer and the aluminum alloy base material, as determined by a glow discharge optical emission spectrometry device, is lower than Fe emission intensity (AIEI) in the aluminum alloy base material, as determined by the glow discharge optical emission spectrometry device.

US Pat. No. 10,767,246

ENHANCED SUPERALLOYS BY ZIRCONIUM ADDITION

General Electric Company,...

1. A Hf-containing, gamma prime nickel-based superalloy, comprising:about 10 wt % to about 22 wt % cobalt;
about 9 wt % to about 14 wt % chromium;
0 wt % to about 10 wt % tantalum;
about 2 wt % to about 6 wt % aluminum;
about 2 wt % to about 6 wt % titanium;
about 1.5 wt % to about 6 wt % tungsten;
about 1.5 wt % to about 5.5 wt % molybdenum;
1.3 wt % to 3.2 wt % niobium;
about 0.01 wt % to 0.8 wt % hafnium;
about 0.02 wt % to about 0.1 wt % carbon;
about 0.01 wt % to about 0.4 wt % boron;
about 0.15 wt % to about 1.3 wt % zirconium; and
the balance nickel and impurities.

US Pat. No. 10,767,243

PURIFICATION PROCESS

Curium US LLC, St. Louis...

1. An apparatus for carrying out a process for purifying Mo-99, the apparatus comprising:a column or vessel containing an adsorbent comprising a zirconium oxide, zirconium hydroxide, zirconium alkoxide, zirconium halide and/or zirconium oxide halide; a source of a solution of a strong base, the source of strong base solution being arranged in fluid communication at an inlet of the column or vessel containing the adsorbent;
a column or vessel containing an anion exchange material on which Mo-99 can be quantitatively adsorbed and arranged in downstream fluid communication with the column or vessel containing the adsorbent;
a source of a solution of an acid, the source of acid solution being arranged in fluid communication at an inlet of the column or vessel containing the anion exchange material; and
a column or vessel containing MnO2 material and arranged in downstream fluid communication with the column or vessel containing the anion exchange material;
a source of a solution of sulfuric acid containing thiocyanide ions and a reducing agent, the source of sulfuric acid solution containing thiocyanide ions and a reducing agent being arranged in fluid communication at an inlet of the column or vessel containing the MnO2 material;
and a column or vessel containing an ion exchange material comprising iminodiacetate groups and arranged in downstream fluid communication with the column or vessel containing the MnO2 material.

US Pat. No. 10,767,242

METHODS AND SYSTEMS FOR LEACHING A METAL-BEARING ORE USING A BIO-AUGMENTATION PROCESS

FREEPORT MINERALS CORPORA...

1. A method comprising:inoculating a first agglomerated ore comprising a metal-bearing material with bacteria to form a first augmented ore;
leaching the first augmented ore comprising bacteria in a heap leach to yield a metal-bearing solution;
directing at least a portion of the metal-bearing solution to a separate growth pond;
adding a nutrient directly to the metal-bearing solution in the separate growth pond to yield a fortified liquid medium; and
directing at least a portion of the fortified liquid medium from the separate growth pond to a second agglomerated ore.

US Pat. No. 10,767,241

SUPPORT FIXTURE FOR HEAT TREATING SHEETS HAVING COMPLEX SHAPES

1. A fixture for holding one or more sheets having complex shapes during heat-treating processes, the fixture comprising:a base having at least one central opening extending there through, the base defining a peripheral foundation;
a support structure having walls extending upwardly from the base and traversely across the at least one central opening of the base, the walls defining a plurality of first axial openings and a plurality of traverse openings;
a sheet engagement structure secured to the support structure, the sheet engagement structure having a peripheral section and at least one connecting leg extending between portions of the peripheral section defining a plurality of second axial openings extending through the sheet engagement structure, the peripheral section and the at least one connecting leg of the sheet engagement structure defining an upper engagement surface configured to conform to a surface of the complex shapes of the one or more sheets to support the one or more sheets on the upper engagement surface of the sheet engagement structure; and,
a sheet securing ring removably secured to the sheet engagement structure forming a peripheral channel disposed between the peripheral section of the sheet engagement structure and the sheet securing ring for slidingly securing the one or more sheets disposed within the peripheral channel to accommodate expansion, contraction and float of the one or more sheets in one or more of an X direction, a Y direction and a Z direction during a first heat-treating process;
wherein the at least one central opening of the base, the plurality of first axial and traverse openings of the support structure and the plurality of second axial openings of the sheet engagement structure are in fluid communication to create a uniform and accelerated flow of fluid through the fixture during the first heat-treating process.

US Pat. No. 10,767,240

COOLANT SPRAY MODULE SYSTEM FOR HEAT TREATED METAL PRODUCT

DAEWON APPLIED ENG. CO., ...

1. A coolant spray module system for a heat treatment metal product, comprising:a first coolant spray module (1A),
wherein the first coolant spray module (1A) comprises a first module housing (10), a first module cover (20), and a first nozzle (30),
wherein the first module housing (10) comprises:
a first passing hole (11) provided in the first module housing (10), wherein the heat treatment metal product passes through the first passing hole (1);
a first coolant distribution pipe (12) provided on the first module housing (10) along an inner circumference of the first module housing (10); and
a coolant supply port (14) provided on an outer circumferential surface of the first module housing (10) and connected to the first coolant distribution pipe (12) via a coolant supply pipe (15),
wherein the first module cover (20) comprises:
a second passing hole (21) provided in the first module cover (20), wherein the heat treatment metal product passes through the second passing hole (21), wherein the first passing hole (11) of the first module housing (10) and the second passing hole (21) are aligned with each other along a first axis, wherein the heat treatment metal product passes through the first passing hole (11) and the second passing hole (21) along the first axis; and
a second coolant distribution pipe (22) provided on the first module cover (20) along an inner circumference of the first module cover (20),
wherein the first coolant distribution pipe (12) and the second coolant distribution pipe (22) are integrated together to form a combined coolant distribution pipe (12, 22), wherein the combined coolant distribution pipe (12, 22) carries a coolant,
wherein the first nozzle (30) comprises:
a first nozzle panel (32) in a disk shape;
a third passing hole formed in the first nozzle panel (32), wherein the heat treatment metal product passes through the third passing hole; and
nozzle grooves (31) provided on the nozzle panel (32) along an inner circumference of the nozzle panel (32),
wherein the first nozzle (30) is fixed between the first module housing (10) and the first module cover (20) by first nozzle fixing blocks (13) and second nozzle fixing blocks (23),
wherein the first nozzle fixing blocks (13) protrudes from the first coolant distribution pipe (12),
wherein the second nozzle fixing blocks (23) protrudes from the second coolant distribution pipe (22),
wherein the heat treatment metal product is in a round-bar shape or a pipe shape,
wherein the coolant spray module system sprays the coolant onto the heat treatment metal product to quench and clean the heat treatment metal product.

US Pat. No. 10,767,239

PRODUCTION METHOD FOR SMELTING CLEAN STEEL FROM FULL-SCRAP STEEL USING DUPLEX ELECTRIC ARC FURNACES

UNIVERSITY OF SCIENCE AND...

1. A production method for smelting clean steel from full-scrap steel using duplex electric arc furnaces, comprising: performing smelting by combining a decarbonization electric arc furnace and 1-3 dephosphorization electric arc furnaces, a specific process of performing the smelting comprises:(1) in a charging period of the 1-3 dephosphorization electric are furnaces, adding the full-scrap steel for the smelting, lime, slag in the decarbonization electric arc furnace, auxiliary materials and carbon powder or a carbon block into the dephosphorization electric arc furnace;
wherein, the full-scrap steel is brought into the dephosphorization electric are furnace using any one or several ways selected from the group consisting of continuous charging, shaft charging and basket charging; the lime, the slag in the decarburization electric arc furnace, the auxiliary materials and the full-scrap steel are all added into the 1-3 dephosphorization electric arc furnaces; an amount of addition of the lime is 0-50 kg per ton of steel; an amount of addition of the slag in the decarburization electric arc furnace is 0-50 kg per ton of steel; the carbon powder or the carbon block is added into a furnace hearth of the dephosphorization electric arc furnace through a charging bin, and an amount for adding or injecting the carbon block or the carbon powder is 0-200 kg per ton of steel;
(2) in a melting period of the full-scrap steel, melting the full-scrap steel in the dephosphorization electric arc furnace through power-on and switching a furnace wall cluster oxygen lance to a burner mode, to increase a temperature in the furnace hearth to melt the full-scrap steel; injecting powder-air flow of a carrier gas and the carbon powder to an interior of molten steel by a submerged spray lance to reduce a melting point of the full-scrap steel; controlling a time of the melting period of the full-scrap steel within 10-150 min, and entering a dephosphorization period once the full-scrap steel is melted down;
wherein, the furnace wall cluster oxygen lance in the burner mode has a first main oxygen flow rate of 100-2000 Nm3/h, a first gas flow rate of 50-1000 Nm3/h, and a first epoxy flow rate of 50-1000 Nm3/h: the carrier gas and a seam protection gas of the submerged spray lance are both any one selected from the group consisting of nitrogen, a fuel gas, carbon dioxide, and a mixture gas of any two of the nitrogen, the fuel gas, and carbon dioxide; a flow rate of the carrier gas is 50-1000 Nm3/h, an injection rate of the carbon powder is 0-200 kg/min, a flow rate of injecting the seam protection gas is 10-1000 Nm3/h, and a particle diameter of the carbon powder is 15 ?m-3.0 mm;
(3) in the dephosphorization period in the dephosphorization electric arc furnace, forming the slag to perform dephosphorization using characteristics of the furnace hearth in an earlier stage of the smelting; switching the furnace wall cluster oxygen lance to an oxygen supply mode to form foam slag; continuing to inject the carbon powder by the submerged spray lance, and controlling a temperature in the decarburization electric arc furnace at 1530-1580° C.; adopting an automatic operation of flowing the slag out of a furnace door, and adding the lime into the decarburization electric arc furnace in a middle stage of the smelting to control basicity of the slag at 2.5-3.5;
wherein, the furnace wall cluster oxygen lance in the oxygen supply mode has a second main oxygen flow rate of 50-2000 Nm3/h, a second gas flow rate of 50-1000 Nm3/h, and a second epoxy flow rate of 50-1000 Nm3/h the injection rate of the carbon powder of the submerged spray lance is 0-200 kg/min, and the amount of addition of the lime is 5-50 kg per ton of steel;
(4) performing a terminal output of the 1-3 dephosphorization electric arc furnaces to an inside of a semisteel ladle, comprising the following steps: sampling the molten steel to measure a phosphorus content and a carbon content in a later stage of the smelting in the 1-3 dephosphorization electric arc furnaces, outputting steel from a bottom of an eccentric furnace when a predetermined standard for the steel is satisfied, and adopting a steel reserve operation to prevent dephosphorization oxidation slag from entering into the decarbonization electric arc furnace;
wherein, a smelting time of the 1-3 dephosphorization electric arc furnaces is controlled at 60-120 min; after a dephosphorization process is finished, the carbon content in the molten steel is controlled between 0.4%-2_wt %, the phosphorus content in the molten steel is controlled below 0.010%, a tapping temperature is greater than 1540° C., and remaining steel in the 1-3 dephosphorization electric arc furnaces is 10%-30% of the total amount of the molten steel;
(5) in a charging period of the decarbonization electric arc furnace, adding the molten steel in the semisteel ladle into the decarburization electric arc furnace, and adding the lime and the auxiliary materials into the decarburization electric arc furnace;
wherein, the molten steel is added into the decarbonization electric arc furnace for charging by ways of a furnace door, a charging tank of a furnace wall or unscrewing a furnace cover; if a special circumstance occurs in a process of entering into the decarbonization electric arc furnace, and the molten steel fails to enter into the furnace, the molten steel is directly cast to steel blocks for use: the amount of addition of the lime in the decarburization electric arc furnace is 2-50 kg per ton of steel;
(6) in a period of decarbonization degassing, detecting a temperature of the molten steel after the molten steel enters into the decarburization electric arc furnace; calculating an oxygen consumption and a power consumption during decarbonization by calculating modules and in combination of a predetermined tapping temperature for the molten steel and the carbon content: forming the slag continuously in the decarburization electric arc furnace, and controlling the basicity of the slag to be 2-3.5; injecting, by the furnace wall cluster oxygen lance and the submerged spray lance, oxygen to the interior of the molten steel according to results of a calculation, blowing argon from the bottom of the eccentric furnace and stirring carbon dioxide; deeply removing [N], [H] and impurities in the molten steel through stirring bubbles generated by a carbon-oxygen reaction, argon, or carbon dioxide in a process of floatation;
wherein, an oxygen supply flow rate of the furnace wall cluster oxygen lance is 50-3000 Nm3/h, an oxygen supply flow rate of the submerged spray lance is 50-2000 Nm3/h, the second gas flow rate of the furnace wall cluster oxygen lance is 50-1000 Nm3/h, a flow rate for blowing argon or carbon dioxide from the bottom of the eccentric furnace is 1-100 NL/min, a power-on time for electrodes is 0-100 min, and a converting time is 10-100 min;
(7) performing an end point control of the decarbonization electric arc furnace, comprising the following steps: sampling the molten steel to measure the phosphorus content, the carbon content and the temperature of the molten steel in the later stage of the smelting, outputting steel, and adopting the steel reserve operation to prevent the slag from entering into the molten steel, and controlling the tapping temperature of the molten steel at 1550-1700° C.;
wherein, the carbon content of the molten steel is controlled above 0.1 wt % after a decarburization process is finished; the phosphorus content of the molten steel is controlled below 0.003%; the slag discharged from the decarbonization electric arc furnace returns back to the 1-3 dephosphorization electric are furnaces for continuing use.

US Pat. No. 10,767,238

GRAY CAST IRON INOCULANT

ELKEM ASA, Oslo (NO)

1. A ferrosilicon inoculant for cast iron consisting ofabout 15 to 90% by weight silicon;
about 0.1 to 10% by weight strontium;
less than about 0.35% by weight calcium;
about 1.5 to 10.0% by weight aluminum;
about 0.1 to 15% by weight zirconium, and
a balance of iron with residual impurities.

US Pat. No. 10,767,237

METHODS OF REFINING A LIGNOCELLULOSIC HYDROLYSATE

VIRDIA, INC., Raceland, ...

1. A method for refining a lignocellulosic hydrolysate, the method comprising:(a) contacting the lignocellulosic hydrolysate with a liquid anion exchange medium (LAEM) in a separation system comprising two liquid-liquid separation centrifuges fluidically coupled in counter-current mode to form a mixture;
(b) separating the mixture in the separation system into an organic stream and an aqueous stream, wherein the organic stream comprises the LAEM, a mineral acid and an impurity selected from the group consisting of an organic acid, a lignin, a phenol, and a furfural, and wherein the aqueous stream comprises one or more sugars;
(c) contacting the organic stream with a base, thereby forming a neutralized mixture; and
(d) recovering a portion of the LAEM from the neutralized mixture;
wherein steps (a) through (b) are a continuous process.

US Pat. No. 10,767,235

MICROARRAY BASED MULTIPLEX PATHOGEN ANALYSIS AND USES THEREOF

PathogenDX, Inc., Scotts...

1. A method for identifying plant DNA, comprising the steps of:a) obtaining a plant tissue sample;
b) isolating total nucleic acids comprising DNA and non-DNA nucleic acids from the plant tissue sample;
c) amplifying, in a first amplification in a single assay, the plant tissue DNA in the total nucleic acids using at least one first primer pair selective for at least one plant-specific DNA to generate one or more plant-specific first amplicons;
d) amplifying, in a second amplification using the one or more plant-specific first amplicons as a template and at least one first fluorescent labeled second primer pair to generate first fluorescent labeled second amplicons;
e) hybridizing the first fluorescent labeled second amplicons with nucleic acid probes specific for signature sequence determinants in the plant DNA, said nucleic acid probes immobilized at specific known positions on a 3-dimensional lattice microarray via second fluorescent labeled bifunctional polymer linkers;
f) washing the 3-dimensional lattice microarray at least once;
g) imaging the 3-dimensional lattice microarray to detect a first fluorescent signal corresponding to the first fluorescent labeled second amplicons and a second fluorescent signal corresponding to the nucleic acid probes immobilized at the specific known positions on the 3-dimensional lattice microarray via the second fluorescent labeled bifunctional polymer linkers;
h) superimposing the first fluorescent signal with the second fluorescent signal to obtain a superimposed signal image; and
i) comparing the sequence of the nucleic acid probe at one or more superimposed signal positions on the 3-dimensional lattice microarray with a database of signature sequence determinants for a plurality of plant DNA, thereby identifying the plant in the plant tissue sample.

US Pat. No. 10,767,226

HONEYCOMB TUBE

Cepheid, Sunnyvale, CA (...

1. A reaction tube comprising:a planar frame defining a fluidic path between a first planar substrate that encloses a first side of the planar frame and a second planar substrate that encloses a second side of the planar frame;
a fluidic interface disposed at one end of the planar frame, the fluidic interface comprising a fluidic inlet of the fluidic path and fluidic outlet of the fluidic path;
wherein the fluidic path further includes a well chamber including a well-substrate configured with a plurality of wells, the well chamber being arranged in the planar frame between the first substrate and a well-substrate on or within the second substrate, the well chamber being in fluidic communication between the fluidic inlet and the fluidic outlet and in fluid communication with the fluidic inlet and the fluidic outlet;
wherein the well-substrate is planar and configured with a plurality of wells that open on one-side of the well-substrate into the well chamber;
wherein the fluidic path includes an inlet passage extending from the fluidic inlet and in fluid communication with the well chamber and an outlet passage in fluid communication with the well chamber and extending to the fluidic outlet; and
wherein fluidic path further includes an intermediate channel between the inlet passage and the well chamber, wherein the intermediate channel includes a plurality of elongated channel portions connected in a serpentine manner.

US Pat. No. 10,767,225

VALVED CARTRIDGE AND SYSTEM

IntegenX, Inc., Pleasant...

1. An instrument comprising a cartridge interface and a cartridge engaged with the cartridge interface, wherein:(I) the cartridge comprises:
(a) a cartridge body comprising a malleable material and having, disposed on a surface of the body, at least one valve body comprising a valve inlet and a valve outlet, each fluidically connected to a fluidic channel, the at least one valve body comprising a groove, the groove comprising a wall including an upper part and a floor, wherein the wall is curved or sloped in a direction that is non-normal to a plane defined by the surface of the body; and
(b) a layer comprising a deformable material attached to a surface of the cartridge body and sealing the at least one valve body at points of attachment, thereby forming at least one valve,
wherein the at least one valve body is depressed in the cartridge body relative to the points of attachment,
wherein the deformable material retains sufficient elasticity after deformation such that in a ground state the valve is open, and
wherein, while the valve is open, the layer is in contact with the upper part, but is not in contact with the floor; and
(II) the cartridge interface comprises:
(A) at least one mechanical actuator, each mechanical actuator positioned to actuate a valve; and
(B) at least one motor operatively coupled to actuate a mechanical actuator toward or away from a valve.

US Pat. No. 10,767,224

HIGH DATA RATE INTEGRATED CIRCUIT WITH POWER MANAGEMENT

Life Technologies Corpora...

1. A method for operating a sequencing system including a sensor array, comprising:applying a sequence of alternating flows of reactant solutions during active intervals and flows of wash solutions during wash intervals;
applying bias arrangements to the sensor array to produce sensor data;
producing streams of sensor data from the sensor array using peripheral circuitry having an active mode and an idle mode; and
switching the peripheral circuitry between the active mode and the idle mode to control power consumption.

US Pat. No. 10,767,222

COMPOSITIONS AND METHODS FOR DETECTING RARE SEQUENCE VARIANTS

ACCURAGEN HOLDINGS LIMITE...

1. A method of distinguishing a sequence variant from an error in a nucleic acid sample comprising a plurality of cell-free polynucleotides, each cell-free polynucleotide of the plurality having a 5? end and a 3? end, the method comprising:(a) circularizing individual cell-free polynucleotides of said plurality to form a plurality of circular polynucleotides, each of which having a junction between the 5? end and 3? end;
(b) amplifying the circular polynucleotides of (a);
(c) sequencing the amplified polynucleotides to produce a plurality of sequencing reads; and
(d) identifying a sequence difference between sequencing reads and a reference sequence as the sequence variant only when the sequence difference occurs in at least two circular polynucleotides having different junctions and not when the sequence difference only occurs in circular polynucleotides having the same junction thereby distinguishing the sequence variant from the error.

US Pat. No. 10,767,221

ENZYME-LINKED NUCLEOTIDES

Illumina, Inc., San Dieg...

1. A modified DNA polymerase comprising:a) a point mutation wherein a surface-exposed amino acid residue is replaced with a cysteine residue;
b) a flexible linker having a first end and second end, the first end covalently attached to the cysteine residue;
c) a nucleotide attached to the second end of the flexible linker, wherein the flexible linker attachment to the nucleotide allows, the nucleotide to interact at a catalytically active region of said modified DNA polymerase and incorporate the nucleotide to the 3? end of a polynucleotide in the presence of a template nucleic acid sequence thereby producing a detectable increase in dwell time at the site of incorporation; and
c) an optically detectable label comprising a fluorophore attached to the modified DNA polymerase.

US Pat. No. 10,767,219

DISPOSABLE, INTEGRATED MICROFLUIDIC CARTRIDGE AND METHODS OF MAKING AND USING SAME

ILLUMINA, INC., San Dieg...

1. A microfluidic cartridge for detecting biological reactions, comprising:(a) a flow cell including a reaction site area encompassing one or more reaction sites; (b) fluidics channels for delivering reactants to and/or removing reactants from the reaction site area; and (c) an image sensor having an active area configured to detect signals of biological reactions in the reaction site area,
wherein:
the reaction site area is proximal to the active area of the image sensor;
the reaction site area spans substantially all of the active area of the image sensor;
the fluidics channels do not substantially overlap with the active area of the image sensor; the flow cell comprises a sequencing chamber; the sequencing chamber is formed on a sequencing chamber layer; the image sensor is disposed in an opening of a sequencing chamber bottom layer under the sequencing chamber layer; and the fluidics channels are formed on a fluidics channels layer under the sequencing chamber bottom layer.

US Pat. No. 10,767,216

METHODS FOR DISTINGUISHING 5-HYDROXYMETHYLCYTOSINE FROM 5-METHYLCYTOSINE

1. A method comprising:(a) obtaining a sample comprising a nucleic acid sequence, wherein said nucleic acid sequence comprises a 5-hydroxymethylcytosine and a 5-methylcytosine;
(b) labeling said 5-hydroxymethylcytosine;
(c) sequencing said nucleic acid sequence; and
(d) distinguishing said 5-hydroxymethylcytosine from said 5-methylcytosine.

US Pat. No. 10,767,213

QUANTIFICATION OF VACCINE COMPOSITIONS

Boehringer Ingelheim Anim...


b) digesting the sample with a protease;
c) running mass-spectroscopic analyses of the sample; and
d) determining an amount of the one or more PCV2 viral proteins in the sample, wherein the one or more PCV2 viral proteins are capable of forming a virus like particle and/or wherein the sample comprises virus like particles composed of a plurality of the one or more PCV2 viral proteins comprising PCV subtype 2a (PCV2a) open reading frame 2(ORF2) and/or PCV subtype 2b (PCV2b) ORF2; wherein the sample is removed from one of: an animal material selected from a body fluid and a tissue, a preparation of the animal material, and a vaccine preparation.

US Pat. No. 10,767,210

FIBER SAMPLER FOR RECOVERY OF BIOAEROSOLS AND PARTICLES

Research Triangle, Inc., ...

1. A method for collecting aerosols, comprising:humidifying or dehumidifying bioparticles in a first gas stream by transport of water vapor a) between an exterior side of a partition member and an interior side of the partition member and b) into a vapor phase of a second gas stream including the bioparticles;
delivering the bioparticles into the second gas stream;
controlling a pressure of the first gas stream on the exterior side of the partition member to adjust a relative humidity for the bioparticles in the second gas stream; and
collecting the bioparticles by a collection medium.

US Pat. No. 10,767,202

TRANSAMINASE REACTIONS

Codexis, Inc., Redwood C...

1. A process for preparing the compound of formula (I):
wherein, R7 is optionally substituted C1-C4 alkyl, and R10 is H, Cl, Br, F, CH3, CF3, CN, SO2, —OCH3, —C(O)CH3, or NO2,
the process comprising:
contacting a ketone substrate of formula:

wherein R7 and R10 are as defined above,
with a transaminase polypeptide in the presence of an amino donor, wherein said amino donor comprises isopropylamine, under reaction conditions suitable for converting the ketone substrate to the compound of formula (I),
wherein the transaminase polypeptide comprises an amino acid sequence that has at least 90% sequence identity to the amino acid sequence of SEQ ID NO: 74, wherein said transaminase polypeptide comprises a substitution at the position corresponding to residue 223 of SEQ ID NO: 2, and is capable of converting the ketone substrate to the compound of formula (I) at a rate that is increased as compared to SEQ ID NO:2.

US Pat. No. 10,767,185

METHOD OF PREPARING PORCINE CIRCOVIRUS TYPE 2 CAPSID PROTEIN AND PHARMACEUTICAL COMPOSITION COMPRISING SAME

AGRICULTURAL TECHNOLOGY R...

1. A composition for preventing porcine circovirus type 2 (PCV2) infection, comprising:an effective amount of 2.5 to 250 ?g/mL PCV2 capsid protein for inducing a protective immune response;
2.5 to 25 ?g/mL porcine interferon-?;
2.5 to 25 ?g/mL porcine interferon-?; and
a pharmaceutically acceptable carrier,
wherein a combination of the porcine interferon-? and the porcine interferon-? elicits a synergistic humoral response to the PCV2 capsid protein.

US Pat. No. 10,767,166

METHODS AND COMPOSITIONS FOR PRODUCTION OF VACCINA VIRUS

SILLAJEN BIOTHERAPEUTICS,...

1. A method for producing a vaccinia virus comprising:(a) infecting HeLa cells adhered to a cell culture bioreactor surface with a Western Reserve strain vaccinia virus by contacting the HeLa cells with the vaccinia virus at a multiplicity of infection (m.o.i.) of between 0.005 and 1.0 plaque forming units (pfu)/cell;
(b) culturing the infected cells in an infection medium having a pH of 7.2 to 7.6 at temperature of 30° C. to 40° C.; and
(c) harvesting vaccinia virus from the culture, whereby at least 50 pfu of vaccinia virus per HeLa cell is produced, calculated as

US Pat. No. 10,767,158

BIOPROTECTION USING LACTOBACILLUS PARACASEI STRAINS

1. An antifungal composition comprising at least one Lactobacillus paracasei strain selected from Lactobacillus paracasei strain CHCC14676 (DSM25612) and mutant strains derived therefrom, wherein the mutant strains have substantially the same or improved antifungal properties as CHCC14676 (DSM25612), wherein the Lactobacillus paracasei strain is capable of inhibiting or preventing the growth of Mucor spp, and wherein the composition comprises an amount of the at least one Lactobacillus paracasei strain effective to inhibit growth of yeasts and molds in the composition and further comprises an effective amount of an added cryoprotectant for the at least one Lactobacillus paracasei strain.

US Pat. No. 10,767,154

TEMPERATURE CONTROLLING SURFACES AND SUPPORT STRUCTURES

GLOBAL LIFE SCIENCES SOLU...

1. A heat exchange module for use in a chemical, pharmaceutical or biological reactor system, comprising:a generally hollow body having an interior space for receiving a replaceable or single use reactant container, and at least one thermally conductive surface adapted to contact the replaceable or single use reactant container to facilitate heat transfer;
a conduit forming a fluid circulation path within the body between an outer wall of the body and an inner wall of the body through which a heat exchange fluid can be circulated; and
at least one baffle protruding from the inner wall of the body surrounding the interior space, the at least one baffle protruding into the interior space.

US Pat. No. 10,767,153

MECHANICAL BIOREACTOR

THE UNIVERSITY COURT OF T...

1. An apparatus comprising:an array of vibration actuators; and
a sample receiving plate vibratably coupled to the array of vibration actuators,
wherein the array of vibration actuators is arranged to vertically oscillate the sample receiving plate at nanoscale amplitudes,
wherein the sample receiving plate has a plurality of sample mounting locations, and wherein the sample receiving plate is configured to:
provide physical engagement to a sample container at each of the plurality of sample mounting locations, and
transmit mechanical vertical vibrations having a substantially uniform nanoscale amplitude across the plurality of sample mounting locations.

US Pat. No. 10,767,152

TANGENTIAL FLOW DEPTH FILTRATION SYSTEMS AND METHODS OF FILTRATION USING SAME

Repligen Corporation, Wa...

1. A bioprocessing system comprising:a process vessel;
a tangential flow depth filtration (TFDF) unit comprising a thick-walled hollow fiber formed from at least one polymer and comprising a porous wall defining a lumen that is in fluid communication with the process vessel;
a permeate fluid outlet in fluid communication with an exterior surface of the porous wall; and
a pump in fluid communication with the lumen;
wherein a density of the hollow fiber is between 51% and 56% of the density of an equivalent solid volume of the polymer.

US Pat. No. 10,767,151

DEVICE FOR CELL CULTURE

CNRS-DAE, Paris (FR) INS...

1. A device for cell culture comprising:a support defining a first microfluidic chamber seeded with a first cell culture, and at least one second microfluidic chamber, and
a fluidic interconnection system connecting the first and the at least one second microfluidic chambers,
wherein:
the fluidic interconnection system is arranged for directing cell connection between the first microfluidic chamber and the at least one second microfluidic chamber, and comprises at least one microchannel, wherein a width of the at least one microchannel monotonically decreases from the first microfluidic chamber to the at least one second microfluidic chamber,
the at least one microchannel comprises at least one portion having a width that decreases from the first microfluidic chamber to the at least one second microfluidic chamber, and configured to promote progression of at least one first type of cell extension compared with at least one second type of cell extension, said first and second types of cell extension differing either by virtue of the microfluidic chamber from which they originate, or by virtue of the cell type of which they are the extension,andeach one of the first microfluidic chamber and the at least one second microfluidic chamber comprises a macrochannel, an end of each macrochannel connected to a reservoir, wherein the at least one microchannel connects the macrochannel of the first microfluidic chamber to the macrochannel of the at least one second microfluidic chamber.

US Pat. No. 10,767,150

EXPANSION KIT FOR BIOREACTORS USED FOR PERFORMING MICROBIAL BIO-ELECTROSYNTHESIS

1. An expansion kit for reversible introduction into a bioreactor for dividing the bioreactor into two separate reaction chambers and for performing microbial bio-electrosynthesis, wherein the expansion kit comprises a reaction chamber which is open at a top and which has a window in a sidewall, said window having a membrane disposed therein, characterized in that the expansion kit is formed such that, when the expansion kit has been introduced into the bioreactor: the reaction chamber of the expansion kit and a reaction chamber of the bioreactor are adjacent to each other on opposite sides of the sidewall and are connected to each other by the membrane disposed in the window of the sidewall, the expansion kit having a reactor lid that covers the open portions of both reaction chambers, the sidewall being coupled to and extending from the reactor lid such that the sidewall is substantially perpendicular to the reactor lid, the reactor lid having at least two through-openings into which electrodes are introduced in such a way that each of the electrodes projects into a separate one of the reaction chambers separated by the membrane and each of the electrodes functions as an anode or cathode.

US Pat. No. 10,767,149

MICROFLUIDIC DEVICE FOR THREE DIMENSIONAL AND COMPARTMENTALIZED COCULTURE OF NEURONAL AND MUSCLE CELLS, WITH FUNCTIONAL FORCE READOUT

Massachusetts Institute o...

1. A microfluidic device for coculture of a muscle cell and a neuronal cell for innervating a muscle bundle, the microfluidic device comprising:a coculture chamber or a plurality of coculture chambers, each of said chamber comprising:
a first culture compartment including one or more retaining features, the first culture compartment having a width of at least 100 ?m;
a second culture compartment including one or more compliant pillars, the second culture compartment having a width of at least 100 ?m; and
a buffer compartment separating the first compartment and the second compartment by a distance of at least about 200 ?m;
wherein the compliant pillars are deflectable to measure force generated by the muscle bundle and the one or more compliant pillars have a height of at least 50 ?m.

US Pat. No. 10,767,147

WIRELESS MODULAR BREWING SENSOR AND BREW MONITORING SYSTEM

1. A wireless modular brewing sensor comprising:a processor housing, comprising:
a power source in communication with the sensor; a microprocessor connected to the power source; a transceiver;
a wireless antenna communicatively coupled to the microprocessor, adapted to send signals to an external control or monitoring system; and
a removable back plate to access the power source, wherein the back plate further comprises a back plate seal member configure to prevent moisture intrusion into the power source; and
a probe housing, comprising:
a probe, wherein said probe is selected from a group comprising: a temperature probe, hydrometer probe, pH probe, flow probe configured to transmit data related to the environmental conditions within a vessel; and
a fitting having an expanded end portion on which is positioned a fitting face, the entire expanded end portion being positioned internal of a vessel and a vessel wall, said fitting further having a coupling end being larger in diameter than said expanded end portion and being spaced from said expanded end portion, at least a portion of said coupling end being positioned external of said brewing vessel and said vessel wall;wherein said processor housing is couplable with said probe housing utilizing a press fit coupling mechanism wherein said coupling end further having a coupling seal configured to inhibit moisture from entering the processor housing and maintaining a coupling relationship between the processor housing and probe housing.

US Pat. No. 10,767,146

BLOOD CULTURE BOTTLES WITH MECHANISMS FOR CONTROLLED RELEASE OF SUBSTANCES INTO CULTURE MEDIA

BECTON, DICKINSON AND COM...

1. An apparatus for a controlled combination of reagents, the apparatus comprising:a vessel adapted for receiving a biological sample having a neck portion and a body portion wherein the body portion of the vessel contains a culture media prior to receiving the biological sample and wherein the body portion of the vessel comprises one or more sensors for monitoring conditions in the culture media or a headspace gas in the vessel;
a cap element attached to the vessel;
a vessel insert secured in the neck portion of the vessel by the cap element and adapted for receiving at least one reagent wherein the at least one reagent is selected from the group consisting of adsorption resin, culture medium, lytic reagent, and a combination thereof, wherein the culture media is a lytic media adapted to grow microorganisms therein, the microorganisms selected from the group consisting of aerobic microorganisms, anaerobic microorganisms, mycobacteria, fungi, and yeast and wherein the culture media is in liquid or lyophilized form;
wherein the cap element further comprises a pierceable aperture through which is received the biological sample into the vessel or vessel insert;
at least one sealing element separating the at least one reagent received by the vessel insert from the body portion of the vessel, and
a rod having a proximal end and a distal end positioned within the vessel so that the proximal end is adjacent to the cap element and distal end is in a first position proximal to the at least one sealing element; and
wherein force applied to the proximal end of the rod results in the distal end of the rod moving from the first position to a second position thereby disrupting the at least one sealing element to allow contents of the vessel insert to release into the body portion of the vessel, and wherein the apparatus is operable to initiate disruption separately from and after receiving of the biological sample via the pierceable aperture into the vessel or vessel insert.

US Pat. No. 10,767,145

SINGLE DOSE SACCHARIDE-BASED SCENT BOOSTING PACKS

1. A single dose scent-boosting pack comprising:a container comprising a water-soluble film; and
a single dose scent-boosting composition encapsulated within said container, wherein said single dose scent-boosting composition comprises:
A. about 0.1 to about 10 weight percent of a fragrance based on a total weight of said scent-boosting composition;
B. about 45 to about 75 weight percent of a saccharide based on a total weight of said scent-boosting composition;
C. about 0.1 to about 6 weight percent of a surfactant based on a total weight of said scent-boosting composition; and
D. about 10 to about 25 weight percent of water based on a total weight of said scent-boosting composition.

US Pat. No. 10,767,144

SOAP REFORMING ASSEMBLY

1. A soap reforming assembly being configured to melt a plurality of soap pieces and subsequently form a bar of soap, said assembly comprising:a housing having a top wall and a front wall, said top wall having an opening extending in an interior of said housing for receiving pieces of soap, said front wall having a form opening extending into an interior of said housing, said front wall having a drawer opening extending into said interior of said housing;
a control circuit being coupled to said housing, said control circuit including an electronic timer;
a soap collection unit being coupled to said housing, said soap collection unit configured for collecting and transporting pieces of soap when the pieces of soap are dropped into said housing via said opening;
a heating element being coupled to said housing, said heating element being in thermal communication with said soap collection unit, said heating element configured for heating said soap collection unit when said heating element is turned on wherein said soap collection unit is configured to melt the soap pieces into a fluid soap when said heating element heats said soap collection unit;
a forming unit being positioned within said housing, said forming unit being electrically coupled to said control circuit, said forming unit arranged for receiving the fluid soap from said soap collection unit, said forming unit configured for cooling and forming the fluid soap into the bar of soap for bathing;
an opener being positioned within said housing, said opener being electrically coupled to said control circuit, said opener is configured to close the forming unit when the forming unit is cooling and forming the fluid soap, said opener is configured to open the forming unit after the forming unit forms the bar of soap, wherein said control circuit is configured to actuate the opener; and
a drawer being slidably positioned in said housing via said drawer opening, said drawer arranged for receiving the bar of soap from said forming unit when said opener opens said forming unit, wherein said drawer is configured to dispense the bar of soap when the drawer is moved to an open position, the open position having said drawer extending outwardly from said housing.

US Pat. No. 10,767,143

PARTICLE REMOVAL FROM ELECTROCHROMIC FILMS USING NON-AQUEOUS FLUIDS

SAGE ELECTROCHROMICS, INC...

1. A method of forming an electrochromic device comprising:depositing a first conductive layer over a substrate;
depositing a first electrode layer over the first conductive layer, wherein the first electrode layer is one of an electrochromic layer or a counter electrode layer;
depositing an ion conductor layer over the first electrode layer, wherein a film stack includes the first conductive layer, the first electrode layer, and the ion conductor layer;
exposing the ion conductor layer to a non-aqueous liquid to remove particulate material having a size between about 0.1 ?m and about 1000 ?m, wherein the non-aqueous liquid is selected from the group consisting of a hydrofluorocarbon, a fluorocarbon, a polymeric fluorinated solvent, and a fluoride surfactant;
depositing a second electrode layer over the film stack after exposing the ion conductor layer to the non-aqueous liquid, wherein the second electrode layer is the other of the electrochromic layer or the counter electrode layer; and
depositing a second conductive layer on the second electrode layer, wherein the electrochromic device has a defect density of less than 1 defect/m2, and wherein the electrochromic device is configured for use in a window.

US Pat. No. 10,767,136

PRO-FRAGRANCE COMPOUNDS

Firmenich SA, Satigny (C...

10. A method of releasing a fragrant compound from a precursor compound, wherein the fragrant compound is selected from the group consisting of a compound of Formula III
by exposing a precursor compound of Formula I:

to an environment wherein the compound is oxidized and wherein R1 and R2 are as set forth in claim 1.

US Pat. No. 10,767,135

METHOD OF PRODUCING OILS AND FATS AND OIL- AND FAT- PRODUCING APPARATUS

Joji Takase, Yokohama-Sh...

1. A method of producing oil comprising:a step of feeding a raw material composed of an agricultural residue or a fishery residue into a reaction vessel;
a step of injecting saturated water vapor in the reaction vessel after the feeding of the raw material;
a step of starting kneading in the reaction vessel with keeping on injecting the water vapor;
a step of terminating the injection of the water vapor at a timing when pressure in the reaction vessel and temperature of a lower part of the reaction vessel respectively rise to a predetermined pressure and a predetermined temperature being set based on a type of the raw material;
a step of depressurizing the interior of the reaction vessel, and then taking a product out from the interior of the reaction vessel; and
a step of extracting oil from the product in an oxygen-free condition,
wherein the step of extracting oil from the product in the oxygen-free condition includes a step of solid-liquid separation where the solid is removed from the product, and a step of obtaining oil by removing water from the liquid obtained in the step of solid-liquid separation, and
the step of extracting oil from the product in an oxygen-free condition is performed in a housing in which nitrogen gas is introduced.

US Pat. No. 10,767,134

LESS CORROSIVE ORGANOMOLYBDENUM COMPOUNDS AS LUBRICANT ADDITIVES

VANDERBILT CHEMICALS, LLC...

1. A molybdate ester represented by the following formula:
where R1 is a hydrocarbon chain, R2 is either a hydrogen atom or a hydrocarbon chain, and m and n are independently from 1 to 5.

US Pat. No. 10,767,133

PROTECTED MERCAPTOPHENOLS AND THIOPHENOLS FOR LUBRICATING COMPOSITIONS

The Lubrizol Corporation,...

1. A lubricating composition comprising:at least 10 wt. % of an oil of lubricating viscosity comprising at least one of an API Group I, Group II, Group III, Group IV, and Group V base oil; and
at least 0.01 wt. % of a compound comprising a protected mercaptophenol represented by the salt form of Formula I:

where R1 is a poly(ether) group;
n is 1;
x is 0, and
a cation selected from metal cations and pnictogen cations, the pnictogen cations being cations comprising elements in column 15 of the periodic table.

US Pat. No. 10,767,132

GUIDING MEMBER IN THE FORM OF A METAL RING FOR ASSEMBLY WITH FRICTION AND WITH THE ARTICULATING AND/OR SLIDING CAPABILITY OF A SHAFT

H.E.F., Andrezieux Bouth...

1. A guidance device, comprising:a metal ring with a bore for assembly with a pin with friction and with a capability for articulation and/or sliding of the pin, the bore having a friction surface and workings suitable to act as a grease reserve to the friction surface, at least the friction surface of the bore having a first wettability,
wherein the friction surface and the workings are provided with a solid layer of self-lubricating coating having a second wettability and being overlaid with grease,
wherein the second wettability is inferior to the first wettability with respect to the grease,
wherein after total wearing of the self-lubricating coating at the friction surface of the bore, a difference in wettability between the friction surface and the workings still having the solid layer of self-lubricating coating is configured to draw out grease from the workings so as to lubricate the friction surface devoid of the solid layer of self-lubricating coating, and
wherein the coating is configured such that if applied to a bearing with a friction surface that is 20 mm wide and of a 30 mm interior diameter, and a 16 NC 6 grade steel pin that is cemented and hardened, and has a surface roughness Ra 0.4 ?m, is alternatingly rotated in the bearing over 100 degrees with a surface pressure of about 50 Mpa at a sliding speed of 8 mm/sec, and the bearing is greased only prior to assembly with a grease containing lithium soap, the friction factor between the pin and the bearing does not increase to the point of failure prior to 320,000 cycles.

US Pat. No. 10,767,130

METHOD AND ADDITIVE FOR CONTROLLING NITROGEN OXIDE EMISSIONS

ADA-ES, Inc., Highlands ...

1. A method for reducing NOx emissions in a pulverized coal boiler system, comprising:contacting a feed material comprising coal particles with an additive composition to form an additive-containing feed material, the additive composition comprising: a nitrogenous material comprising one or more of ammonia, an amine, an amide, cyanuric acid, a nitride, and urea; a binder; and a thermal stability agent comprising one or more of a metal hydroxide, a metal carbonate, a metal bicarbonate, a metal hydrate, and a metal nitride, wherein the thermal stability agent is bound by the binder to and substantially surrounds the nitrogenous material and wherein a molar ratio of the thermal stability agent:nitrogenous material ranges from about 1:1 to about 10:1; and
combusting the additive-containing feed material to produce a contaminated gas stream comprising a contaminant produced by combustion of the coal particles and the additive composition or a derivative thereof, wherein the additive composition or the derivative thereof removes or causes removal of the contaminant.

US Pat. No. 10,767,128

COPOLYMER SUITABLE FOR USE AS A DETERGENT ADDITIVE FOR FUEL

TOTAL MARKETING SERVICES,...

1. A fuel composition comprising:(1) a fuel derived from one or more sources chosen from the group consisting of mineral, animal, plant and synthetic sources; and
(2) from 10 to 5000 ppm of one or more copolymers obtained by copolymerization of at least:
non-polar monomer (ma) corresponding to the following formula (I)
where:u=0 or 1,
w=0 or 1,
E=—O— or —NH(Z)—, or —O—CO—, or —NH—CO— or —CO—NH—, with Z representing H or a C1-C6 alkyl group, it being understood that when E=—O—CO— E is connected to the vinyl carbon by the oxygen atom, and
G represents a group selected from the group consisting of (i) a C4-C34 alkyl, (ii) an aromatic ring, and (iii) an aralkyl comprising at least one aromatic ring and at least one C1-C34 alkyl group, and
a polar monomer (mb) chosen from those of the following formula (II):
where:t=0 or 1,
Q is chosen from an oxygen atom and a group —NR?— with R? being chosen from a hydrogen atom and C1 to C12 hydrocarbon-based chains, and
R is a C1 to C34 hydrocarbon-based chain substituted with at least one quaternary ammonium group and optionally one or more hydroxyl groups.

US Pat. No. 10,767,127

CHEMICALS AND FUEL BLENDSTOCKS BY A CATALYTIC FAST PYROLYSIS PROCESS

ANELLOTECH, INC., Pearl ...

1. A catalytic fast pyrolysis process for preparing chemicals comprising steps of:i) feeding biomass, catalyst composition, and transport fluid to a catalytic fast pyrolysis process fluidized bed reactor maintained at reaction conditions to manufacture a raw fluid product stream,
ii) feeding the raw fluid product stream of step i) to a solids separation and stripping system to produce separated solids and a fluid product stream,
iii) feeding the fluid product stream of step ii) to a quench vapor/liquid separation system utilizing water or hydrocarbon quench to produce a liquid phase stream comprising water, char, coke, ash, catalyst fines, oxygenates, and C9+ aromatics, and a vapor phase stream comprising carbon monoxide, carbon dioxide, hydrogen, olefins, and aromatics, said aromatics selected from the group consisting of benzene, toluene, xylenes, phenols, naphthols, benzofuran, ethylbenzene, styrene, naphthalene, methylnaphthalene and combinations thereof,
iv) feeding the vapor phase stream of step iii) to a condensation system to produce an organic phase stream,
v) feeding the organic phase stream of step iv) to a separation system to produce a high boiling fraction and a low boiling fraction,
vi) feeding the low boiling fraction of step v) to a separation system to produce a fraction boiling above 85° C. and a fraction boiling below 85° C.,
vii) hydrogenating at least a portion of the fraction boiling below 85° C. of step
vi) at hydrogenating conditions to produce a hydrogenated fraction, and
viii) recovering chemicals comprising at least 10% by volume cyclohexane from the hydrogenated fraction of step vii), in a product recovery system.

US Pat. No. 10,767,125

GROUP III BASE STOCKS AND LUBRICANT COMPOSITIONS

EXXONMOBLE RESEARCH AND E...

1. A Group III base stock comprising;at least 90 wt. % saturated hydrocarbons:
kinematic viscosity at 100° C. of 4.0 cSt to 5.0 cSt;
a viscosity index of 120 to 140;
a ratio of multi-ring naphthenes to single ring naphthenes (2R+N/1RN) of less than 0.52; and
a ratio of branched carbons to straight chain carbons (BC/SC) less than or equal to 0.21.

US Pat. No. 10,767,124

PROCESS FOR RECOVERING HYDROGEN AND LIQUEFIED PETROLEUM GAS FROM GASEOUS STREAMS

UOP LLC, Des Plaines, IL...

1. A process for recovering hydrogen comprising:hydroprocessing a hydrocarbon feed stream in a hydroprocessing reactor to provide a hydroprocessed effluent stream;
separating said hydroprocessed effluent stream in a separation section comprising a separator to provide a liquid separated hydroprocessed stream and a gaseous separated hydroprocessed stream;
stripping said liquid separated hydroprocessed stream to provide a stripper gaseous stream having a pressure of about 0.35 MPa (gauge) to about 2.0 MPa (gauge);
increasing the pressure of the stripper gaseous stream to about 1.4 MPa (gauge) to about 6.9 MPa (gauge);
absorbing C3+ hydrocarbons from said gaseous separated hydroprocessed stream and said stripper gaseous stream together by contact with a sponge oil in a sponge absorber, wherein said sponge absorber operates at an overhead pressure of between about 1.4 MPa (gauge) and about 6.9 MPa (gauge); and
recovering hydrogen from said gaseous separated hydroprocessed stream and said stripper gaseous stream together.

US Pat. No. 10,767,123

COIL-WOUND HEAT EXCHANGER FOR HYDROTREATMENT OR HYDROCONVERSION

AXENS, Rueil Malmaison (...

1. A device suitable for hydroconversion or hydrotreatment of a hydrocarbon feedstock, comprising:a single coil-wound heat exchanger (S-1), said coil-wound exchanger being a single-pass heat exchanger formed by a vertical chamber in which one or more bundles of tubes are helically wound around a central core, as numerous superposed layers, suitable for: preheating and directly distributing the hydrocarbon feedstock and optionally a hydrogen stream or a hydrocarbon feedstock/hydrogen stream mixture to a reactor inlet furnace (F-1) of a hydrotreatment or hydroconversion reaction section (R-1), and cooling reaction effluent from the hydrotreatment or hydroconversion reaction section (R-1); the reactor inlet furnace (F-1) for heating and distributing the preheated hydrocarbon feedstock/hydrogen stream mixture to the hydrotreatment or hydroconversion reaction section (R-1); the hydrotreatment or hydroconversion reaction section (R-1) suitable for hydrotreating or hydroconverting the hydrocarbon feedstock; a high-pressure cold separator (B-2) suitable for separating at least one portion of cooled reaction effluent into a first liquid effluent comprising at least one light fraction and a first gaseous effluent comprising hydrogen; and a separation column (C-1) suitable for separating the first liquid effluent comprising at least one light fraction into a bottoms liquid and an overhead effluent and further comprising a first bypass (19) suitable for directly distributing a portion of the hydrocarbon feedstock or a portion of the hydrocarbon feedstock/hydrogen stream mixture from the inlet of the coil-wound heat exchanger (S-1) to the outlet of the coil-wound heat exchanger (S-1).

US Pat. No. 10,767,122

METHOD FOR PRODUCING HIGH-QUALITY FEEDSTOCK FOR A STEAM CRACKING PROCESS

SABIC GLOBAL TECHNOLOGIES...

1. A method for producing high-quality feedstock for a steam cracking process, said method comprising the steps of:i.) providing an aromatics and naphthenes containing hydrocarbon feedstock;
ii.) contacting said hydrocarbon feedstock with furfural at a dosage effective to remove aromatics and naphthenes from said feedstock forming a refined feedstock and one or more aromatics and naphthenes containing streams;
iii.) processing said refined feedstock in a steam cracking process;
wherein step ii) comprises two sub steps, namely a step iia) comprising separation of aromatics from said hydrocarbon feedstock of step i) thereby forming a naphthenes containing intermediate stream and an aromatics containing stream, and a step iib) comprising separation of naphthenes from said intermediate stream thereby forming a naphthenes containing stream and said refined feedstock;
wherein said hydrocarbon feedstock originates from a naphthenic crude oil;
wherein step iia) comprises a temperature range of 50 to 125° C. and a solvent dosage within a range of 50 to 450 percent;
wherein said hydrocarbon feedstock has a boiling range in a range of 300-550° C.;and wherein the refined feedstock consists of paraffinic vacuum gas oil that does not contain aromatics or naphthenes.

US Pat. No. 10,767,120

METHOD OF OPERATING AN EBULLATED BED PROCESS TO REDUCE SEDIMENT YIELD

Shell Oil Company, Houst...

1. A method of operating an ebullated bed process for the hydroconversion of a heavy hydrocarbon feedstock, wherein said method comprises:providing an ebullated bed reactor system, comprising an ebullated bed reactor vessel that defines a reactor volume within which is an ebullated bed reaction zone defined by a catalyst bed comprising first shaped hydroprocessing catalyst particles having a first geometry providing for a first ratio of the cross section perimeter-to-cross sectional area that is less than 5 mm?1, and wherein said reactor volume further includes an upper zone above said ebullated bed reaction zone and a lower zone below said ebullated bed reaction zone;
introducing said heavy hydrocarbon feedstock into said ebullated bed reaction zone, which is operated under hydroconversion reaction conditions;
removing a portion of said first shaped hydroprocessing catalyst particles from said catalyst bed at a removal rate in the range upwardly to 5% of the total weight of catalyst inventory within said reactor volume per day of operation;
replacing said first shaped hydroprocessing catalyst particles removed from said catalyst bed by adding to said catalyst bed an incremental amount of a second shaped hydroprocessing catalyst particles at an addition rate in the range upwardly to 5% of the total weight of catalyst inventory within said reactor volume per day of operation, wherein said second shaped hydroprocessing catalyst particles have a second geometry that is polylobal and provides for a second ratio of the cross section perimeter-to-cross sectional area that is at least 5 mm?1 and less than 8 mm?1 and a cross sectional area-to-particle volume in the range of from 5 mm?1 to 15 mm?1; and
yielding from said reactor volume a heavy hydrocarbon conversion product having a reduced sediment content.

US Pat. No. 10,767,119

AMPHIPHILIC ASPHALTENE IONIC LIQUIDS AS DEMULSIFIERS FOR HEAVY PETROLEUM CRUDE OIL-WATER EMULSIONS

King Abdulaziz University...

1. A method of demulsifying a petroleum crude oil-water emulsion, comprisingcombining a first petroleum crude oil-water emulsion with a quantity of an amphiphilic asphaltene ionic liquid sufficient to demulsify the first petroleum crude oil-water emulsion,
wherein the amphililic asphaltene ionic liquid is or comprises an asphaltene quaternary alkylaminopyridinium cation with one or more different organic anionic salts, and
wherein the amphililic asphaltene ionic liquid is made by either
a) oxidizing one or more alkyl chains on a periphery of asphaltene molecules to form asphaltene carboxylic acids (ACA),
converting carboxylic acid groups to acid chlorides forming asphaltene acid chlorides (As—COCl), and
reacting the As—COCl with one or more quaternized ethoxylated alkyl pyridinium salts,
or
b) reacting the asphaltene with malic anhydride to form asphaltene malic anhydride adducts (AMA) which have one or more carboxylic acids on a periphery of the AMA molecules,
converting carboxylic acid groups to acid chlorides forming asphaltene acid chlorides (As—COCl), and
reacting the As—COCl with one or more quaternized ethoxylated alkyl pyridinium salts,
or
c) reacting the asphaltene with malic anhydride to form asphaltene malic anhydride adducts (AMA) which have one or more carboxylic acids on a periphery of the AMA molecules, and
reacting the AMA molecules with one or more quaternized ethoxylated alkyl pyridinium salts.

US Pat. No. 10,767,117

ENHANCED LIGHT OLEFIN YIELD VIA STEAM CATALYTIC DOWNER PYROLYSIS OF HYDROCARBON FEEDSTOCK

SAUDI ARABIAN OIL COMPANY...

1. A method for steam and catalytic cracking of hydrocarbons, the method comprising the steps of:supplying a catalyst feed, where the catalyst feed comprises a fluid and a heterogeneous catalyst, the heterogeneous catalyst operable to catalyze cracking of the hydrocarbons on surfaces of the heterogeneous catalyst, the hydrocarbons comprising a crude oil feed;
supplying steam, where the steam is operable to effect steam cracking of the hydrocarbons, and where the steam is operable to decrease coking of the heterogeneous catalyst, the amount of steam supplied to effect steam catalytic cracking resulting in a product stream comprising ethylene and propylene with total yield of ethylene and propylene together at about at least 20% from the crude oil feed; and
mixing the hydrocarbons, the catalyst feed, and the steam to produce light olefins by steam cracking and catalytic cracking simultaneously, while operating at a temperature to produce light olefins, and residence time to prevent secondary reactions responsible for consumption of the light olefins, where the heterogeneous catalyst flows downwardly by gravity.

US Pat. No. 10,767,114

PYROLYSIS SYSTEM AND METHOD FOR BIO-OIL COMPONENT EXTRACTION

Tolero Energy, LLC, Sacr...

1. A pyrolysis system comprising:a pyrolyzer;
a primary condenser, coupled to the pyrolyzer and configured to receive pyrolytic vapors from the pyrolyzer, and further configured to condense the pyrolytic vapors by contacting the pyrolytic vapors with a non-polar condensing liquid, to form a component mixture, such that the component mixture is phase separated into multiple separated phases, the component mixture including a non-polar bio-oil component originating from the pyrolytic vapors and a non-polar solvent component not originating from a pyrolysis process;
wherein at least a portion of the non-polar condensing liquid comprises a fraction that is extracted as a separated stable phase from a second bio-oil component mixture resulting from a prior pyrolysis cycle.

US Pat. No. 10,767,113

LIQUID CRYSTAL COMPOUND CONTAINING 2,3,4-TRISUBSTITUTED BENZENE AND COMPOSITION THEREOF

SHIJIAZHUANG CHENGZHI YON...

1. A liquid crystal composition, wherein the liquid crystal composition comprises one or more compounds of formula I and one or two compounds of formula II-B,
wherein R1 represents an alkyl group having a carbon atom number of 1-10, a fluoro-substituted alkyl group having a carbon atom number of 1-10, an alkoxy group having a carbon atom number of 1-10, a fluoro-substituted alkoxy group having a carbon atom number of 1-10, an alkenyl group having a carbon atom number of 2-10, a fluoro-substituted alkenyl group having a carbon atom number of 2-10, an alkenoxy group having a carbon atom number of 3-8 or a fluoro-substituted alkenoxy group having a carbon atom number of 3-8, and any one or more non-connected CH2 in the groups represented by R1 may be substituted with cyclobutyl, cyclopropyl or —O—;
Y represents ethyl or vinyl;
R2 represents F, OCF3, OCHF2 or OCH2F;

each independently represent one of

 and any fluorobenzene; and
m and n each independently represent 1 or 2.

US Pat. No. 10,767,112

METHODS OF PRODUCING METAL SULFIDES, METAL SELENIDES, AND METAL SULFIDES/SELENIDES HAVING CONTROLLED ARCHITECTURES USING KINETIC CONTROL

The Trustees of the Colum...

1. A method of preparing metal sulfide, metal selenide, metal sulfide/selenide, mixed metal sulfide, mixed metal selenide, or mixed metal sulfide/selenide nanoparticles, the method comprising:(a) contacting at least two precursor metal salts with a sulfur-containing precursor, a selenium-containing precursor, or a combination or mixture of the sulfur- and selenium-containing precursors, or
(b) contacting a precursor metal salt with a sulfur-containing precursor, a selenium-containing precursor, or a mixture of sulfur- and selenium-containing precursors,
in each case where plural precursor metal salts and/or sulfur-/seleno-containing precursors are employed, the contacting being done simultaneously or sequentially in either order in a solution, each precursor metal salt being capable of reacting with each sulfur- and selenium-containing precursor to form the corresponding metal sulfide and metal selenide, the contacting giving rise to reaction conditions sufficient to control at least one parameter of particle size, particle distribution, and particle composition of the nanoparticles to-a predetermined architecture, the sulfur- or selenium-containing precursor each independently having a structure of Formula (I), Formula (II), or Formula (III), or an isomer, salt, or tautomer thereof,

 wherein
Q1 is independently —O—, —S—, Se—, —CR3R4—, —N(R4)— or P(R4)—;
Q2 is independently —O—, —S—, Se—, —CR3R4—, —N(R3)— or P(R3)—;
Q3 is an optionally substituted aryl or optionally substituted heteroaryl;
R1, R2, R3, and R4 are independently at each occurrence H, optionally substituted C1-24 alkyl, optionally substituted C3-12 cycloalkyl, optionally substituted C2-24 alkenyl, optionally substituted C3-12 cycloalkenyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted heteroaryl, or optionally substituted heteroaralkyl;
or any two of R1, R2, R3, and R4 are, within the same structure, linked to form a 5- to 10-membered heterocycle comprising an optionally substituted alkylene or an optionally substituted and/or conjugated alkenylene linkage;
or optionally one or more of R1, R2, and R3 is not H;
R5 is halogen, —CN, —NO2, C1-6 alkoxy, C1-6 alkyl, C3-6 cycloalkyl, C2-6 alkenyl, optionally substituted aryl, optionally substituted aryloxy, optionally substituted aralkyl, optionally substituted heteroaryl, or optionally substituted heteroaralkyl;
q is 0, 1, 2, or 3;
X is S or Se; and
Y is a bond —O—, —S—, or —N(R3)—;
with the provisos that, in Formula (I):
when Q1R1 is NH2, then Q2R2 is not CH3;
when Q2R2 is NH2, then Q1R1 is not CH3; and
when Q1 is —N(R4)— and Q2 is —N(R3)—, then R1 and R2 are linked to form a 5- or 6-membered heterocycle comprising an optionally substituted alkylene linkage or a 6-membered heterocycle comprising an optionally substituted alkenylene linkage.

US Pat. No. 10,767,111

PHOSPHOR COMPOSITION

CREE, INC., Durham, NC (...

1. A method of making a phosphor composition that down-converts photons in the blue and ultraviolet portions of the visible spectrum into photons in the longer wavelength portions of the visible spectrum, the method comprising:forming a mixture comprising:
a cation from the group consisting of calcium, strontium, lithium, sodium, potassium, rubidium, cesium, magnesium, barium, scandium, yttrium, lanthanum, gadolinium, and lutetium; with
a cation from the group consisting of aluminum, silicon, boron, gallium, carbon, germanium, and phosphorus; with
an anion selected from the group consisting of nitrogen, sulfur, chlorine, bromine, and iodine; and with an activator selected from the group of europium (II), cerium (Ill), ytterbium (II), samarium (II) and manganese (II);
heating the mixture in the presence of a forming gas at or near atmospheric pressure; and
forming from the mixture a first phase comprising a nitride phosphor.

US Pat. No. 10,767,108

PERFLUOROETHER-STABILIZED QUANTUM DOTS

3M INNOVATIVE PROPERTIES ...

1. A composite particle comprising a fluorescent core/shell nanoparticle and a fluoroether ligand bound to the surface of the nanoparticle of the formula:Rf—[X1—R2—X2—R3(L)n]m
wherein
Rf is a perfluoroether group,
R2 is a hydrocarbyl group including alkylene, arylene, alkarylene and aralkylene;
R3 is a hydrocarbyl group including alkylene, arylene, alkarylene and aralkylene;
X1 is —CH2—O—, —O—, —S—, —CO2—, —CONR1—, or —SO2NR1? where R1 is H or C1-C4 alkyl;
X2 is a covalent bond, —S—, —O— or —NR1—, —CO2—, —CONR1—, or —SO2NR1? where R1 is H or C1-C4 alkyl;
n at least one;
m is 1 or 2
L is an ligand group selected from —CO2H, —SH, —P(O)(OH)2, —P(O)OH, —NH2—OH, and —SO3H.

US Pat. No. 10,767,106

VISCOSITY REDUCTION SYSTEM FOR MICROWAVE EXTRACTION OF HEAVY OIL AND PREPARATION METHOD THEREOF

CHINA UNIVERSITY OF PETRO...

1. A viscosity reduction system for microwave extraction of heavy oil, wherein the viscosity reduction system is a magnetic graphene oxide; wherein the magnetic graphene oxide is compounded by Fe3O4 nanospheres and a graphene oxide; wherein the mass ratio of the Fe3O4 nanospheres to the graphene oxide is 2:1;the viscosity reduction system is produced by the following steps:
(1) preparing a catalyst suspension: adding the Fe3O4 nanospheres into deionized water to obtain a suspension, and adjusting the suspension to be acidic by an acid to obtain a catalyst suspension;
(2) preparing a carrier solution: adding graphene oxide into deionized water, and stirring to obtain a graphene oxide carrier solution;
(3) placing the catalyst suspension obtained in step (1) in a flask, introducing nitrogen into the flask, and heating in a constant temperature water bath of 60° C.;
(4) adding the graphene oxide carrier solution into the flask heated in the constant temperature water bath of step (3) dropwise while stirring to obtain a mixed solution; wherein the weight ratio of the graphene oxide carrier solution to the catalyst suspension is 1:2;
(5) placing the mixed solution obtained in step (4) in an infiltration bag to obtain a magnetic graphene oxide precipitate; and
(6) placing the magnetic graphene oxide precipitate obtained in step (5) in a vacuum oven for drying to obtain the viscosity reduction system.

US Pat. No. 10,767,105

REDISPERSION OF SCHIZOPHYLLAN

BASF SE, Ludwigshafen (D...

1. A method for preparing a concentrated polysaccharide mass, wherein the method comprises:(1) blending the concentrated polysaccharide mass having a polysaccharide concentration [c1] in the range from ?50 g to ?800 g of polysaccharide per liter of concentrated polysaccharide mass, to obtain a mash having a polysaccharide concentration [c2] in the range from ?5 g to ?50 g of polysaccharide per liter of mash, wherein the blending comprises adding a first dilution liquid, and during the blending a particle size of particles of the concentrated polysaccharide mass is decreased and mixing with the first dilution liquid proceeds;
(2) homogenizing the mash having a polysaccharide concentration [c2], in order to obtain a homogenized mash having a polysaccharide concentration [c3] in the range from ?5 g to ?50 g of polysaccharide per liter of homogenized mash, wherein, during the homogenization, homogenization of particles in the mash proceeds;
(3) diluting the homogenized mash having a polysaccharide concentration [c3], in order to obtain a diluted homogenized mash having a polysaccharide concentration [c4] in the range from ?0.05 g to ?2.0 g of polysaccharide per liter of diluted homogenized mash, wherein the dilution comprises addition of a third dilution liquid,
wherein the ratio of [c1] to [c4] is in the range from ?1:30 to ?1:20 000.

US Pat. No. 10,767,104

COMPOSITIONS FOR ENHANCED OIL RECOVERY

Ecolab USA Inc., St. Pau...

1. A method of increasing recovery of crude oil from a subterranean hydrocarbon-containing formation, the method consisting essentially of:forming an emulsion, the emulsion consisting of
(i) one or more coupling agents,
(ii) one or more water soluble or dispersible nonionic surfactants having an HLB greater than about 10,
(iii) one or more zwitterionic surfactants,
(iv) one or more anionic surfactants, and
(v) water;
optionally combining the emulsion with one or more oil field additives selected from the group consisting of viscosifying agents, solvents, alkali, non-emulsifiers, corrosion inhibitors, biocides, friction reducers, emulsion breakers, and proppants;
contacting the emulsion with a high total dissolved solids water source comprising at least about 4 wt % nonpolymeric solids dissolved therein to form a fracturing fluid, the fracturing fluid comprising about 98 wt % to 99.99 wt % of the high total dissolved solids water source;
injecting the fracturing fluid into a subterranean hydrocarbon-containing formation; and
collecting a hydrocarbon from the subterranean hydrocarbon-containing formation.

US Pat. No. 10,767,102

CLEAN GRAVEL PACK FLUID COMPOSITION AND METHOD FOR SAND CONTROL APPLICATIONS

HALLIBURTON ENERGY SERVIC...

1. A method of gravel packing a wellbore penetrating a subterranean formation comprising:providing a gravel packing fluid comprising a particulate agent and hydroxypropyl starch phosphate, wherein the hydroxypropyl starch phosphate is present in the gravel packing fluid in an amount of about 0.1 to 10 weight percent of the gravel packing fluid; and
contacting the subterranean formation with the gravel packing fluid so as to place a gravel pack in or near a portion of the subterranean formation.

US Pat. No. 10,767,100

COMPATIBILIZED RESIN-CEMENT COMPOSITE COMPOSITIONS

Halliburton Energy Servic...

1. A method of treating a subterranean formation, comprising:placing a resin-cement composite composition into a subterranean formation, wherein the resin-cement composite composition comprises:
a resin;
a cement; and
a substituted or unsubstituted poly(alkylamine) compatibilizer having the following structure:

wherein:
at each occurrence, R1 is selected from the group consisting of —H and a substituted or unsubstituted (C1-C30)hydrocarbyl,
at each occurrence, R2 is a substituted or unsubstituted (C1-C30)hydrocarbylene,
at each occurrence, R3 is selected from the group consisting of —H, a substituted or unsubstituted (C1-C30)hydrocarbyl, and a substituted or unsubstituted (C1-C30)hydrocarbylene terminated with —NR12, and
m1 is 3 to about 50,000.

US Pat. No. 10,767,099

COMPOSITIONS AND METHODS FOR SEALING OFF FLOW CHANNELS IN CONTACT WITH WET CEMENT

Saudi Arabian Oil Company...

15. A method of treating a subterranean formation, the method comprising:providing to the subterranean formation a composition comprising:
a maleic anhydride copolymer comprising:
first repeat units I and II:

wherein each R1 is independently selected from the group consisting of —H, —O(C1-C5) alkyl, and —(C1-C5) alkyl, and each R2 is independently selected from the group consisting of —H, —O(C1-C5) alkyl, and —(C1-C5) alkyl;
an amine crosslinker; and
a gelling agent comprising at least one of:
a calcium chelating agent;
a calcium precipitating agent;
a pH buffer;
an agent reactive with hydroxide; or
an acid generating agent; and
crosslinking the maleic anhydride copolymer of the composition with the amine crosslinker of the composition to form a sealant, wherein the gelling agent promotes formation of the sealant in contact with set cement.

US Pat. No. 10,767,096

DATE TREE WASTE-BASED BINARY FIBROUS MIX FOR MODERATE TO SEVERE LOSS CONTROL

Saudi Arabian Oil Company...

1. A lost circulation material (LCM) composition, the composition consisting of:a first plurality of fibers produced from date tree trunks, wherein each of the first plurality of fibers produced from date tree trunks has a diameter in the range of 0.4 millimeters (mm) to about 0.8 mm; and
a second plurality of fibers produced from at least one of date tree leaves and date tree leaf stems, wherein each of the second plurality of fibers produced from at least one of date tree leaves and date tree leaf stems has a diameter in the range of 0.5 millimeters (mm) to about 1 mm.

US Pat. No. 10,767,094

NANOSILICA DISPERSION WELL TREATMENT FLUID

Saudi Arabian Oil Company...

1. A treatment fluid for reducing water production in a treatment zone in a wellbore, comprising:an acidic nanosilica dispersion, the acidic nanosilica dispersion comprising amorphous silicon dioxide, water, and acetic acid; and
an alkanolamine, the alkanolamine selected to form a gelled solid after interaction with the acidic nanosilica dispersion for a period,
wherein the acidic nanosilica dispersion has a pH of less than 7 before interaction with the alkanolamine and a pH of at least 9 after the treatment fluid contacts the treatment zone in the carbonate formation.

US Pat. No. 10,767,093

PHASE CHANGE COMPOSITIONS

SunAmp Limited, Edinburg...

1. A phase change material in the form of a thermodynamically stable aqueous liquid composition which is resistant to the nucleation of crystalline sodium acetate on heating and cooling, the thermodynamically stable aqueous liquid composition comprising:a mixture of sodium acetate anhydrous with at least one suitable alkali soluble polymer for inhibition of sodium acetate anhydrous crystal formation and crystalline sodium acetate trihydrate; and at least one sodium acetate trihydrate nucleation promoter wherein the phase change material is in the form of an aqueous solution which comprises:
from 40% to 60% of sodium acetate anhydrous;
from 0.1% to 10% of at least one alkali soluble polymer;
from 0.1% to 5% of at least one nucleation promoter;
optionally, from 1% to 25% of a melting point depressing agent; and
water to balance.

US Pat. No. 10,767,091

HEAT TRANSFER COMPOSITIONS, METHODS, AND SYSTEMS

HONEYWELL INTERNATIONAL I...

1. A refrigerant comprising at least about 97% by weight of the following four compounds, with each compound being present in the following relative percentages: 36.8 to 72% by weight trifluoroiodomethane (CF3I);2 to 36% by weight of tetrafluoropropene selected from trans-1,3,3,3-tetrafluoropropene (HFO-1234ze(E), 2,3,3,3-tetrafluoropropene (HFO-1234yf) and combinations of these;
15 to 31% by weight difluoromethane (HFC-32); and
1 to 4.5% by weight pentafluoroethane (HFC-125).

US Pat. No. 10,767,089

THERMOPLASTIC POLYMER COMPOSITION AND MOLDED ARTICLE

KURARAY CO., LTD., Kuras...

1. An adhesive comprising:100 parts by mass of a thermoplastic elastomer (A) that is a polystyrene-polyisoprene-polystyrene triblock copolymer comprising (i) 13 to 30 mass % of styrene units and (ii) polyisoprene blocks having a total amount of 1,2-bonds and 3,4-bonds of 60 to 78 mol %, and
25 to 60 parts by mass of a maleic anhydride modified polypropylene resin (B) per 100 parts by mass of the thermoplastic elastomer (A), the maleic anhydride modified polypropylene resin (B) having a melt flow rate of 10 to 250 g/10 min under the conditions of 230° C. and a load of 21.18N,
provided that a thermoplastic polymer composition containing 1 part by mass or more of a polyvinyl acetal resin is excluded from the adhesive,
wherein a polar group-containing structural unit is present in the maleic anhydride modified polypropylene resin (B) in an amount of 3.0 to 6.0 mass %, based on a total mass of the maleic anhydride modified polypropylene resin (B).

US Pat. No. 10,767,088

PHOTOREVERSIBLE ADHESIVE AGENT

NATIONAL INSTITUTE OF ADV...

1. A photo-reactive pressure-sensitive adhesive agent comprising, as a main component, a polymeric compound with a weight average molecular weight of 3,000 to 800,000 represented by General Formula (1):wherein A represents a block polymer of monomers represented by Formula (2) below with a molecular weight of 1,000 to 100,000; and B represents a block polymer with a molecular weight of 1,000 to 400,000 having a glass transition point and a melting point of 20° C. or lower, which is liquid or plastically deformable at room temperature, wherein B does not absorb light of a wavelength range of 350 to 600 nm:wherein R1 represents a group having an azobenzene structure represented by Formula (3) below; n is an integer of 2 to 18; m is an integer of 0 to 16; and R2 represents hydrogen or a methyl group.

US Pat. No. 10,767,086

AQUEOUS ADHESIVE COMPOSITION BASED ON POLYALDEHYDE AND POLYPHENOL

Compagnie Generale Des Es...

1. An aqueous adhesive composition comprising:an unsaturated elastomer latex; and
a phenol/aldehyde resin, wherein the phenol/aldehyde resin is based on at least:
an aromatic polyaldehyde including at least one aromatic nucleus bearing at least two aldehyde functional groups, and
a flavonoid.

US Pat. No. 10,767,084

ENHANCED ADHESIVE MATERIALS AND PROCESSES FOR 3D APPLICATIONS

International Business Ma...

1. A method of making a polymer based composite system for an electronic device, comprising:forming a dielectric layer over a device sublaminate;
depositing metal catalyst nanoparticles at a plurality of sites on a top surface of the dielectric layer;
growing a plurality of carbon nanotubes over the device sublaminate at the plurality of sites to a uniform length and in a vertical growth direction, thereby causing the metal catalyst nanoparticles to be positioned at top portions of the carbon nanotubes;
backfilling the plurality of carbon nanotubes and the metal catalyst nanoparticles with a polymer base resin, the polymer base resin having a thermal stability of 350° Centigrade or above and being compatible with copper, the plurality of carbon nanotubes and the polymer base resin forming a composite layer;
removing an upper portion of the polymer base resin, thereby causing the polymer base resin to have a thickness substantially equal to the uniform length of the plurality of carbon nanotubes; and
removing the metal catalyst nanoparticles.

US Pat. No. 10,767,079

ICE-PHOBIC COATING FORMULATIONS AND USES THEREOF

AMES RUBBER CORPORATION, ...

1. An ice-phobic coating formed by curing a solventless coating formulation comprising:an elastomer;
nanoparticles present in an amount from 1 wt % to 5 wt % based on a total weight of the solventless coating formulation; and
a cryoprotectant present in an amount from 1 wt % to 3 wt % based on the total weight of the solventless coating formulation.

US Pat. No. 10,767,077

LOAD-BEARING MEMBER SURFACE TREATMENT

OTIS ELEVATOR COMPANY, F...

16. A method of removing wax from a surface of a substrate, comprising applying a liquid composition to the surface of the substrate, said liquid composition consisting of 5-95 wt. % of a water-soluble organic polyol or water-soluble polymer, 2-50 wt. % of a surfactant, optionally an ionic strength booster selected from the group consisting of sodium chloride, potassium chloride, sodium bromide, potassium bromide and combinations of the foregoing, and the balance of the liquid composition being water to a total of 100 wt. %, each of the weight percentages based on the total weight of the liquid composition, said weight percentages subject to the limitation that the water-soluble organic polyol or a water-soluble-organic polymer is present in an amount within a solubility limit of the water-soluble organic polyol or water-soluble organic polymer in water, wherein said water-soluble organic polyol or a water-soluble-organic polymer comprises propylene glycol, ethylene glycol, polyethylene glycol, glycerin, pentaerythritol, sucrose, sucralose, polyacrylic acid, polyvinyl alcohol, ethylene vinyl alcohol, polyacrylamide, dextran, glucose, or polysaccharide.

US Pat. No. 10,767,073

CURABLE FILM-FORMING COMPOSITIONS CONTAINING HYDROXYL FUNCTIONAL, BRANCHED ACRYLIC POLYMERS AND MULTILAYER COMPOSITE COATINGS

PPG Industries Ohio, Inc....

1. A curable film-forming composition comprising:(a) a polymeric binder comprising repeating ester groups in the polymer backbone and further comprising a plurality of carbamate groups of the structure:

(b) a curing agent comprising functional groups that are reactive with the carbamate functional groups of (a); and
(c) a reaction product of:
(1) a hydroxyl functional (meth)acrylic polymer comprising the reaction product of:
(i) at least 1 percent by weight of a (meth)acrylic monomer comprising at least two ethylenically unsaturated double bonds;
(ii) at least 10 percent by weight of a (meth)acrylic monomer comprising a carbon atom that is bonded to four moieties wherein one of said moieties is a hydrogen atom and the remainder of said moieties comprises an alkyl group, wherein at least one of the alkyl group-containing moieties comprises an ethylenically unsaturated double bond; and
(iii) at least one ethylenically unsaturated monomer that is polymerizable with (i) and (ii); wherein each monomer (i), (ii), and (iii) is different and wherein the monomer (i), (ii) and/or (iii) contains a hydroxyl functional group; and
(2) a lactone or lactam; wherein the reaction product (c) has a weight average molecular weight of at least 500 to 8504.

US Pat. No. 10,767,062

SYSTEM AND METHOD FOR FORMING ACTIVATED CARBON AEROGELS AND PERFORMING 3D PRINTING

Lawrence Livermore Nation...

1. A 3-D printing ink, comprising:water;
an organic thickener selected from the group consisting of water soluble cellulose derivatives, polyoxyalkylene compounds, polyvinyl alcohol, and mixtures thereof;
a resin that comprises resorcinol and formaldehyde;
an acid catalyst that catalyzes a reaction between the resorcinol and formaldehyde; and
a thixotropic additive;
wherein the 3-D printing ink does not contain graphene oxide; and
wherein the 3-D printing ink is a viscous thixotropic ink that is operable to gel after printing to form a printed part.

US Pat. No. 10,767,060

ULTRA-STABLE PRINTING AND COATINGS USING AQUEOUS COMPLEX COACERVATES, AND COMPOSITIONS AND METHODS THEREOF

University of Massachuset...

1. A method for forming a coating on a substrate, comprising:providing an aqueous coacervate suspension comprising a polyanion or macroanion, a polycation or macrocation, and a salt;
coalescing the aqueous coacervate suspension into a homogeneous coacervate phase; and
depositing the coacervate phase on a substrate to form a coating on the substrate, wherein the polycation or macrocation comprises poly(diallyldimethyl ammonium), the polyanion or macroanion comprises poly(styrene sulfonate), and the salt comprises KBr.

US Pat. No. 10,767,058

CONTROLLED RELEASE MATERIALS FOR ANTI-CORROSION AGENTS

United States of America ...

1. A corrosion inhibitor material comprising:particles comprising:
(I) a complex comprising:
(a) an ionic surfactant, an ionic polymer, an ionic polymer precursor, or an ionic liquid; and
(b) an ionic water-soluble corrosion inhibitor;
wherein (a) and (b) have opposite charges and (a) and (b) are bonded to one another;
wherein the particles are embedded in the framework of: a solid or gel matrix structure;
wherein the particles have (i) the property that if they are placed in an aqueous solution in an acidic pH they release some of the water-soluble corrosion inhibitor, (ii) the property that if they are placed in an aqueous solution in a basic pH they release some of the water-soluble corrosion inhibitor, or (iii) the property that if they are heated they release some of the water-soluble corrosion inhibitor.

US Pat. No. 10,767,055

MINERAL MATERIAL POWDER WITH HIGH DISPERSION ABILITY AND USE OF SAID MINERAL MATERIAL POWDER

Omya International AG, O...

1. A process for preparing a ground mineral material in the absence of a dispersing agent consisting of the steps of:a) wet grinding mineral material in at least one grinding step in an aqueous suspension or slurry in the absence of a dispersing agent until the mineral material has a weight median particle diameter d50 from 1.1 ?m to 1.5 ?m, wherein the mineral material is selected from the group consisting of marble, chalk, dolomite, calcite, limestone, magnesium hydroxide, talc, gypsum, titanium oxide, and any mixture thereof;
b) up-concentrating or dewatering the aqueous suspension or slurry of step a) in the absence of a dispersing agent to achieve a solids content of between 50% and 70%;
c) drying the aqueous suspension or slurry of step a) or b) to achieve a solid content of 99.8%, wherein no dispersing agent is present in the mineral material so obtained; and
d) optionally surface treating the mineral material obtained in step c) with at least one aliphatic carboxylic acid; and
e) optionally de-agglomerating the mineral material after step d), wherein the calcium carbonate after grinding in step a) and before optional treatment in step d) has a BET/N2 specific area of from 3 m2/g to 13 m2/g, wherein the mineral material obtained in step c) has a top cut d98 of 1.8 ?m-5.9 ?m.

US Pat. No. 10,767,051

CURED BODY AND MULTILAYERED SUBSTRATE

SEKISUI CHEMICAL CO., LTD...

1. A cured body of a resin composition including an epoxy compound, a curing agent, an inorganic filler, and a polyimide,a content of the inorganic tiller being 30% by weight or more and 90% by weight or less in 100% by weight of the cured body,
the cured body having a sea-island structure having a sea part and an island part, the island part having an average long diameter of 5 ?m or less, and the island part containing the polyimide.

US Pat. No. 10,767,050

LIQUID HIGH SOLIDS BINDER COMPOSITION

Knauf Insulation, Inc., ...

1. A method of fabricating a fiberglass or stone wool product, comprising spraying a liquid, curable, thermosetting, aqueous, substantially formaldehyde free, binder composition, which is free of solid particles, which comprises a primary or secondary polyetheramine and a carbohydrate and which has a concentration of at least 35% solids on a collection of glass or stone wool fibers; dehydrating the aqueous binder composition disposed on the collection of glass or stone wool fibers to form an uncured fiberglass or stone wool product; and subjecting the uncured fiberglass or stone wool product to heat to cure the binder composition.

US Pat. No. 10,767,049

LIQUID CRYSTALLINE POLYMER COMPOSITION FOR CAMERA MODULES

Ticona LLC, Florence, KY...

1. A camera module comprising a polymer composition that comprises a liquid crystalline polymer, an inorganic particulate material having a hardness value of about 2.5 or more based on the Mohs hardness scale and a median particle size of from about 0.1 to about 35 micrometers, and an epoxy-functionalized olefin copolymer, wherein the polymer composition exhibits a tensile elongation at break of about 3.5% or more, as determined in accordance with ISO Test No. 527:2012 at 23° C.

US Pat. No. 10,767,044

IONIZING RADIATION RESISTANT POLYCARBONATE RESIN COMPOSITION AND MOLDED ARTICLE CONTAINING SAME

Lotte Advanced Materials ...

1. A polycarbonate resin composition, comprising:a polycarbonate resin; and
about 0.1 parts by weight to 0.375 parts by weight relative to about 100 parts by weight of the polycarbonate resin of a polycarbonate polyol having a number average molecular weight of about 1,000 g/mol to about 5,000 g/mol and containing terminal hydroxyl groups; a repeat unit represented by Formula 1a; and a repeat unit represented by Formula 1b:

where R2 is a C1 to C4 linear alkylene group or a C3 to C4 branched alkylene group; and

where R3 is a C5 to C15 linear alkylene group, a C5 to C15 branched alkylene group, or a C5 to C15 cyclic alkylene group.

US Pat. No. 10,767,041

POLYMER COMPOSITIONS AND SUBSTRATES FOR HIGH TEMPERATURE TRANSPARENT CONDUCTIVE FILM APPLICATIONS

Eastman Chemical Company,...

1. A polymer composition comprising a blend of a first PCTA copolyester and a second PCTA copolyester,said first PCTA copolyester comprising:
(a) diacid residues comprising from about 90 to about 99 mole percent of terephthalic acid (TPA) residues and from about 1 to about 10 mole percent isophthalic acid (IPA) residues; and
(b) diol residues comprising at least 85 mole percent of 1,4-cyclohexanedimethanol (CHDM) residues, wherein the first PCTA copolyester comprises a total of 100 mole percent diacid residues and a total of 100 mole percent diol residues;
said second PCTA copolyester comprising:
(a) diacid residues comprising from 70 to 80 mole percent of TPA residues and from 20 to 30 mole percent IPA residues; and
(b) diol residues of 100 mole percent of CHDM residues, wherein the second PCTA copolyester comprises a total of 100 mole percent diacid residues and a total of 100 mole percent diol residues;
wherein the first PCTA copolyester is semi-crystalline;
wherein the second PCTA copolyester is amorphous; and
wherein the blend comprises diacid residues comprising from about 5 to about 20 net mole percent of IPA residues, wherein the blend comprises a total of 100 mole percent diacid residues and a total of 100 mole percent diol residues.

US Pat. No. 10,767,038

RUBBER MODIFIED VINYL-BASED GRAFT COPOLYMER, AND THERMOPLASTIC RESIN COMPOSITION CONTAINING SAME

Lotte Advanced Materials ...

1. A thermoplastic resin composition comprising:a rubber-modified vinyl-based graft copolymer having a core-shell structure, in which a shell is formed by graft polymerization of a monomer mixture to a core comprising a rubber polymer,
wherein the monomer mixture comprises about 30 wt % to about 80 wt % of an aromatic monomer comprising an alpha position-substituted aromatic vinyl-based monomer represented by Formula 1 and an aromatic vinyl-based monomer other than the alpha position-substituted aromatic vinyl-based monomer, wherein the alpha position-substituted aromatic vinyl-based monomer and the aromatic vinyl-based monomer other than the alpha position-substituted aromatic vinyl-based monomer are present in a weight ratio of about 0.5:1 to about 5:1; about 10 wt % to about 30 wt % of a vinyl cyanide-based monomer; and about 10 wt % to about 30 wt % of a maleimide-based monomer:

wherein R1 is a C1 to C5 alkyl group and Ar is a substituted or unsubstituted C6 to C20 aryl group or a substituted or unsubstituted C7 to C20 alkylaryl group; and
an aromatic vinyl-based copolymer resin,
wherein the thermoplastic resin composition has an Izod impact strength of about 20 kgf·cm/cm to about 40 kgf·cm/cm, as measured on a ¼? thick specimen in accordance with ASTM D256, a melt-flow index of about 3 g/10 min to about 5 g/10 min, as measured at 200° C. under a load of 10 kg in accordance with ISO 1133, and a Vicat softening temperature (VST) of about 110° C. to about 130° C., as measured under a load of 5 kg in accordance with ASTM D1525.

US Pat. No. 10,767,037

HYALURONIC ACID CONJUGATES AND USES THEREOF

UNIVERSITE DE GENEVE, Ge...

1. A graft polymer of a hyaluronic acid polymer and a N-isopropylacrylamide based polymer wherein the hyaluronic acid polymer and the N-isopropylacrylamide based are conjugated through at least one linker L of Formula (II):
wherein one of Ra and Rb is covalently linked to the N-isopropylacrylamide based polymer and one of Ra and Rb is covalently linked to the hyaluronic acid polymer and when Ra or Rb is covalently linked to the N-isopropylacrylamide based polymer, it is equal to R1 and when Ra or Rb is covalently linked to the hyaluronic acid polymer, it is equal to R3, wherein R1 is a group selected from (CH2)x—NH(CH2)y—S—, —(CH2)x—NH—O—C(O)—(CH2)y—S—, —(CH2)x—NH—(CH2)y—C(O)—NH—(CH2)z—S—, —(CH2)x—O—C(O)—CR7R8—, —C(O)—(CH2)x—C(O)—NH—(CH2)z—S and an optionally substituted polyethylene chain wherein R7 and R8 are optionally substituted C1-C6 alkyl; R3 is a group -E-G-L1- wherein E is either absent or selected from —C(O)—NR9—, —C(O)—O— and —C(O)—, G is linker group selected from optionally substituted C1-C20 alkyl, optionally substituted polyethylene glycol (PEG) chain, optionally substituted acylamino C1-C6 alkyl, optionally substituted acyl C1-C6 alkyl, optionally substituted aminocarbonyl C1-C6 alkyl and optionally substituted C1-C6 alkoxy and L1 is selected from —NR10C(O)—, —C(O)—NR10—, —C(O)—O— and —C(O)— wherein R9 and R10 are independently selected from H and optionally substituted C1-C6 alkyl; A is an optionally substituted C5-C10-cycloalkyl, or optionally substituted heterocycloalkyl ring wherein R5 represents one or more substituent(s) independently selected from H, optionally substituted alkoxy and optionally substituted C1-C6 alkyl; x, y and z are integers independently selected from 1 to 20 or any pharmaceutically acceptable salts thereof.

US Pat. No. 10,767,035

METHOD FOR PRODUCING THERMOPLASTIC RESIN COMPOSITION FILM

RIKEN TECHNOS CORPORATION...

1. A method for producing a film comprising a thermoplastic resin composition, the method comprising:(1) a step of subjecting a thermoplastic resin composition to preliminary heating at 100 to less than 190° C.;
(2) a step of subjecting a first roller and second roller of a calender-roll film-forming apparatus to pre-heating at 100 to 190° C. for each of the first and second rollers; and
(3) a step of introducing the thermoplastic resin composition, which has been subjected to preliminary heating in step (1), into a clearance between the first roller and second roller, which have been pre-heated in step (2), and continuously winding a melted film of the thermoplastic resin composition on the first roller,
wherein a rotation rate of the first roller is faster than a rotation rate of the second roller, and
wherein a ratio of the speed of the first roller to the speed of the second roller ranges from 1.3:1 to 3:1, which is kept at a constant ratio during the production of the film.

US Pat. No. 10,767,033

ASPHALT COMPOSITIONS AND METHODS OF MAKING SAME

Kraton Polymers LLC, Hou...

1. A coupled block copolymer composition comprising: (i) a diblock copolymer comprising one block of a monovinylaromatic hydrocarbon and one block of a conjugated diene, and having a peak molecular weight from 30,000 to 78,000, and a vinyl content from 8 to 80 mol percent based on the number of repeat monomer units in the conjugated diene block, (ii) a linear triblock copolymer having a peak molecular weight that is 1.5 to 3.0 times the peak molecular weight of the diblock copolymer, and (iii) a multiarm coupled block copolymer having a peak molecular weight that is 1.5 to 9.0 times the peak molecular weight of the diblock copolymer,wherein the ratio of (i) to (ii) in the block copolymer composition is less than 1;
wherein the coupled block copolymer composition has a sufficient coupling efficiency to have a melt viscosity at less than 110° C. of greater than 2.0E7 Poise;
wherein the composition is prepared in a reaction mixture consisting of a diblock copolymer, a coupling agent, a microstructure control reagent, and a solvent, wherein the diblock copolymer is coupled with the coupling agent, and wherein the coupling agent is represented by Formula I:
wherein Y is R, OR, SR?, or X (where X?F, Cl, Br and/or I); Z is O, S, or NR? where R, R?, and R? are independently an alkyl group or an aryl group; and Ar is an aromatic group comprises one or more rings;and wherein the coupled block copolymer composition, heated at 180° C. for 24 hours, decouples to a coupling efficiency of less than 20%.

US Pat. No. 10,767,032

BISTABLE AUXETICS

1. An auxetic metamaterial comprising an assembly of a plurality of interconnected building blocks displaceable relative to each other, the building blocks including rotating elements defining sides interconnected to each other at vertex points and translating elements pivotally connected to the rotating elements at the vertex points, the vertex points defining hinges between the rotating elements and the translating elements, a shape of the rotating elements different than that of the translating elements, the assembly being non-plastically and reversibly deformable from a collapsed position to an expanded position upon application of a first load, and the assembly being non-plastically and reversibly deformable from the expanded position to the collapsed position upon application of a second load, the assembly being bistable and thereby defining a first stable state in the collapsed position and a second stable state in the expanded position, wherein in the first stable state the assembly maintains the collapsed position after removal of the second load applied thereon and, in the second stable state, the assembly maintains the expanded position after removal of the first load applied thereon, and wherein, between the expanded position and the collapsed position, the translating elements being substantially non-rotatable from the first stable state to the second stable state, the building blocks move relative to each other such that the assembly deforms toward a closest one of the expanded position and the collapsed position after removal of either of the first load and the second load applied on the assembly, a dimension of the assembly of the plurality of interconnected building blocks taken in a direction normal to a direction of application of the first load being greater in the expanded position than that in the collapsed position.

US Pat. No. 10,767,030

OPTICAL ARTICLE AND OPTICAL FILTER COMPRISING SAME

LMS Co., Ltd., Pyeongtae...

1. An optical article comprising:a transparent base containing one or more near-infrared absorbing dyes, and
wherein an absorption spectrum measured using a spectrophotometer in a wavelength range of 380 to 1,200 nm has two or more absorption peaks including first and second absorption peaks as below,
the first absorption peak has an absorption maximum (?max1) in a wavelength range of 650 to 750 nm,
the second absorption peak has an absorption maximum (?max2) in a wavelength range of 830 to 980 nm, and
when an optical density value (OD1) at the absorption maximum of the first absorption peak is normalized to be 1, an optical density value (OD2) at the absorption maximum of the second absorption peak satisfies the following Equation 1:
0.03 wherein the optical article comprises
a first selective wavelength reflection layer formed on a first main surface of the transparent base; and
a second selective wavelength reflection layer formed on a second main surface of the transparent base, and
satisfies the following Equation 3:
0.8 in Equation 3,
D1 represents a thickness of the first selective wavelength reflection layer, and
D2 represents a thickness of the second selective wavelength reflection layer; and
wherein the first and second selective wavelength reflection layers are each independently formed of a dielectric multilayer film, and satisfy the following Equation 4:
0?|P1?P2|<6  [Equation 4]
in Equation 4,
P1 represents the number of stacked layers of the dielectric multilayer film constituting the first selective wavelength reflection layer, and
P2 represents the number of stacked layers of the dielectric multilayer film constituting the second selective wavelength reflection layer.

US Pat. No. 10,767,024

SOFT ACTUATOR AND METHODS OF FABRICATION

Cornell University, Itha...

1. A method for producing a soft actuator, comprising the steps of:combining two or more materials into a mixture, wherein a first material is an elastomer material and a second material is an additive material;
curing the mixture to obtain a cured mixture that produces an elastomeric foam structure with an open-celled architecture in the form of an interconnected network of pore elements with each pore element defined by a wall; and
sealing the structure of the soft actuator by coating it in a sealant material, wherein the actuator is configured to be operated by fluid inflation and deflation; and
wherein the coated sealant material is configured to seal the elastomeric foam structure and prevent release of fluid into a surrounding environment during fluidic inflation and deflation.

US Pat. No. 10,767,023

POROUS WATER-SOLUBLE NONIONIC CELLULOSE ETHER HAVING EXCELLENT SOLUBILITY AND METHOD FOR PRODUCING THE SAME

Shin-Etsu Chemical Co., L...

1. A method for continuously producing a porous water-soluble nonionic cellulose ether having an average pore size of 36 ?m or smaller and an average particle size of from 30 to 300 ?m, comprising the steps of:pulverizing a first water-soluble nonionic cellulose ether to obtain a first pulverized product, and
sieving the first pulverized product through a sieve having an opening of from 40 to 400 ?m to obtain a first residue-on-sieve and a first sieve-passing fraction,
wherein a portion or all of the first residue-on-sieve containing particles having particle sizes smaller than and greater than the opening of the sieve is re-pulverized together with a second water-soluble nonionic cellulose ether in the step of pulverizing to obtain a second pulverized product, which is sieved to obtain the porous water-soluble nonionic cellulose ether as a second sieve-passing fraction containing the re-pulverized particles; and
wherein each of the first and second residues-on-sieve contains 10% by weight or more of particles having particle sizes smaller than the opening of the sieve.

US Pat. No. 10,767,022

FIBER WOUND BODY, FIBER-REINFORCED RESIN MATERIAL, AND METHOD FOR MANUFACTURING FIBER WOUND BODY

KABUSHIKI KAISHA TOYOTA J...

1. A fiber wound body comprising:reinforced fiber yarns wound about a winding axis, wherein
each of the reinforced fiber yarns includes a gradual cross-section change portion, and
the gradual cross-section change portion has a fiber content rate that is constant in a longitudinal direction of the yarn and has a cross section that gradually changes.

US Pat. No. 10,767,021

CUT SHEET AND METHOD FOR REDUCING CUTS

TBM CO., LTD., Tokyo (JP...

1. A cut sheet that is formed of a resin composition including inorganic particles of 50% by mass or larger relative to a total mass of the composition and a thermoplastic resin, whereinthe cut sheet has a water absorption rate of 10% or lower measured in accordance with JIS K-7209, and
an actual occupancy rate of an exposed area of inorganic particles is lower by at least 2% than a theoretical occupancy rate of an area of inorganic particles in at least one end face.

US Pat. No. 10,767,018

ISOTACTIC POLYPROPYLENE BASED COMPOSITE

1. A process for producing an isotactic polypropylene based composite, comprising: reactive blending of an isotactic polypropylene homo-polymer; a polypropylene grafted with a carboxylic anhydride or a furan type moiety; and an amino silane, in the presence of an organically modified nanoclay to produce an isotactic polypropylene based composite.

US Pat. No. 10,767,016

VAPOR-PHASE CURING CATALYSIS AND PASSIVATION OF SILOXANE RESINS IN LED APPLICATIONS

LUMILEDS LLC, San Jose, ...

1. A method comprising:contacting a solid viscoelastic film with a first catalyst that is in a vapor phase, the solid viscoelastic film comprising an uncured polymer; and
curing the uncured polymer after the solid viscoelastic film is contacted with the first catalyst to provide a cured polymer,
laminating the solid viscoelastic film over a light emitting device.

US Pat. No. 10,767,013

POROUS/NANOPOROUS PHT

International Business Ma...

1. An article comprising a porous polymer having a plurality of hexahydrotriazine units, a plurality of hemiaminal units, or a combination thereof, the porous polymer having an average pore size less than about 100 nm and density less than about 1.5 g/cm3, wherein the porous polymer has a plurality of hexahydrotriazine units having the general structure
or a plurality of hemiaminal units having the general structure

wherein at least one starred bond of each hexahydrotriazine unit or hemiaminal unit is bonded to a bridging group, and wherein each bridging group is a divalent bridging group or a trivalent bridging group and is bonded to at least two hexahydrotriazine units or hemiaminal units.

US Pat. No. 10,767,002

POLYCYCLOOLEFIN POLYMER AND INORGANIC NANOPARTICLE COMPOSITIONS AS OPTICAL MATERIALS

PROMERUS, LLC, Brecksvil...

1. A composition comprising:a) one or more monomers of formula (I):

wherein:
m is an integer 0, 1 or 2;
R1, R2, R3 and R4 are the same or different and each independently selected from the group consisting of hydrogen, halogen, methyl, ethyl, linear or branched (C3-C16)alkyl, perfluoro(C1-C12)alkyl, hydroxy(C1-C16)alkyl, (C3-C12)cycloalkyl, (C6-C12)bicycloalkyl, (C7-C14)tricycloalkyl, (C6-C10)aryl, (C6-C10)aryl(C1-C6)alkyl, perfluoro(C6-C10)aryl, perfluoro(C6-C10)aryl(C1-C3)alkyl, tri(C1-C6)alkoxysilyl and a group of formula (A):
—Z-Aryl  (A)
wherein:
Z is a bond or a group selected from the group consisting of:
(CR5R6)a, O(CR5R6)a, (CR5R6)aO, (CR5R6)a—O—(CR5R6)b, (CR5R6)a—O—(SiR5R6)b, (CR5R6)a—(CO)O—(CR5R6)b, (CR5R6)a—O(CO)—(CR5R6)b, (CR5R6)a—(CO)—(CR5R6)b, where a and b are integers which may be the same or different and each independently is 1 to 12;
R5 and R6 are the same or different and each independently selected from the group consisting of hydrogen, methyl, ethyl, linear or branched (C3-C6)alkyl, hydroxy, methoxy, ethoxy, linear or branched (C3-C6)alkyloxy, acetoxy, (C2-C6)acyl, hydroxymethyl, hydroxyethyl, linear or branched hydroxy(C3-C6)alkyl, phenyl and phenoxy;
Aryl is phenyl or phenyl substituted with one or more of groups selected from the group consisting of methyl, ethyl, linear or branched (C3-C6)alkyl, hydroxy, methoxy, ethoxy, linear or branched (C3-C6)alkyloxy, acetoxy, (C2-C6)acyl, hydroxymethyl, hydroxyethyl, linear or branched hydroxy(C3-C6)alkyl, phenyl and phenoxy;
b) a latent organo-ruthenium compound selected from the group consisting of a compound of formula (IIIA) and a compound of formula (IIIC):
andwherein:
X is selected from the group consisting of chlorine and iodine;
Y is O;
L is PR3, where R is independently selected from the group consisting of isopropyl, sec-butyl, tert-butyl, cyclohexyl, bicyclo(C5-C10)alkyl, phenyl, benzyl, isopropoxy, sec-butoxy, tert-butoxy, cyclohexyloxy, phenoxy and benzyloxy;
each R8 is independently selected from the group consisting of methyl, ethyl, linear or branched (C1-C6)alkyl, (C6-C10)aryl, methoxy, ethoxy, linear or branched (C1-C6)alkoxy, (C6-C10)aryloxy, —NHCO(C1-C6)alkyl, —NHCO-perfluoro(C1-C6)alkyl, —SO2N((C1-C6)alkyl)2 and —NO2;
Ar3 and Ar4 are the same or different and each independently selected from the groan consisting of substituted or unsubstituted phenyl, substituted or unsubstituted biphenyl and substituted or unsubstituted naphthyl;
wherein said substituents are selected from the group consisting of methyl, ethyl, iso-propyl, tert-butyl and phenyl; and
c) one or more additives selected from the group consisting of a photoactive acid generator, a photoactive base generator, a thermal acid generator, a thermal base generator and a mixture in any combination thereof; and wherein
said monomer of formula (I) is having a refractive index of at least 1.5 and said composition is in a clear liquid form at room temperature.

US Pat. No. 10,766,993

ABA BLOCK COPOLYMER, DISPERSANT, AND PIGMENT DISPERSION COMPOSITION

OTSUKA CHEMICAL CO., LTD....

1. An ABA block copolymer comprising:an A block containing a structural unit represented by a general formula (1) below and a structural unit derived from a vinyl monomer with an acid group; and a B block containing a structural unit derived from a vinyl monomer with an aromatic ring group or an alicyclic alkyl group, the ABA block copolymer having an acid value of 30 to 250 mgKOH/g,

wherein in the general formula (1) R1 is a hydrogen atom or a methyl group and R2 is an alkyl group having 2 to 10 carbon atoms,
the structural unit represented by the general formula (1) is at a content of 20 to 80% by mass in 100% by mass of the A block
and wherein the content of the structural unit derived from a vinyl monomer with an acid group is, in 100% by mass of the A block, 5 to 40% by mass.

US Pat. No. 10,766,991

SULFONATE GROUP-CONTAINING POLYMER AND METHOD OF PRODUCING THE SAME

NIPPON SHOKUBAI CO., LTD....

1. A sulfonate group-containing copolymer, comprising:a structural unit (a) derived from a sulfonate group-containing monomer (A);
a structural unit (b) derived from a (poly)oxyalkylene monomer (B) represented by the following formula (1):
wherein R1 represents a hydrogen atom or a methyl group; R2 represents a direct bond, CH2, or CH2CH2; and X0 represents a structural unit represented by the following formula (2):—Zn—OR0  (2)wherein Z may be the same or different and each represents a structural unit derived from a C2-C5 alkylene oxide; R0 represents hydrogen atom or a methyl group; and n is an integer of from 5 to 100; anda structural unit (c) derived from a carboxyl group-containing monomer (C) that is at least one selected from the group consisting of (meth)acrylic acid, maleic acid, maleic anhydride, and salts thereof,
wherein the sulfonate group-containing copolymer comprises from 2% to 38% by mass of the structural unit (a), from 9% to 70% by mass of the structural unit (b), and from 20% to 90% by mass in an acid form equivalent of the structural unit (c) in 100% by mass of all the structural units constituting the sulfonate group-containing copolymer,
wherein the product (P×Mw×n) of the ratio by mass P of the structural unit (b) to the structural unit (a) multiplied by the weight average molecular weight Mw of the sulfonate group-containing copolymer multiplied by the value n in the formula (2) is from 950,000 to 33,300,000,
wherein the sulfonate group-containing monomer (A) is at least one of 2-acrylamide-2-methylpropanesulfonic acid and a compound represented by the following formula (3):
wherein R3 represents a hydrogen atom or a methyl group; R4 represents a direct bond, CH2, or CH2CH2; X and Y each represent a hydroxy group or SO3M where M represents a hydrogen atom, Li, Na, or K, and at least one of X and Y is SO3M,wherein the sulfonate group-containing copolymer optionally comprises a structural unit (e) derived from a monomer (E) that is none of the monomer (A), the monomer (B), and the monomer (C) in an amount no more than 20% by mass based on 100% by mass of the structural units (a), (b), (c), and (e), and
wherein the degree of neutralization of the sulfonate group-containing copolymer is 1 to 100 mol %,
wherein an anti-redeposition property exhibited by the sulfonate group-containing copolymer, evaluated as follows, is 64.8% to 68.1%:

In evaluation of anti-redeposition properties under high hardness condition, clay is used in item (4) as soil
(1) A cotton cloth obtained from Testfabrics, Inc. is cut into 5 cm×5 cm to prepare white clothes and whiteness of each of the white clothes is previously measured as reflectance using colorimetry color difference meter SE6000 type produced by Nippon Denshoku Industries Co., Ltd.
(2) Pure water is added to calcium chloride dihydrate (5.0 g) to prepare hard water (17 kg)
(3) Pure water is added to polyoxyethylene (8) lauryl ether (4.0 g) to prepare an aqueous surfactant solution (100.0 g) and pH is controlled to 8.5 with sodium hydroxide
(4) The temperature of a Terg-o-Tometer was set at 25° C., to a pot are added hard water (1 L), an aqueous surfactant solution (5 g), a 2% (solids content) aqueous polymer solution (1 g), and test powder 1 (class 11) (1 g) according to JIS Z 8901, the contents are stirred for 1 min at 100 rpm, five white cloths are put into the solution, and the solution is stirred for 10 min at 100 rpm
(5) The white cloths are wrung by hand, and hard water (1 L) at 25° C. is charged into the pot, and is stirred for 2 min at 100 rpm
(6) Each of the white cloths is pressed with a filler cloth to be dried while smoothing wrinkles, and the dried clothes are measured for whiteness again as reflectance with the above colorimetric difference meter
(7) From the measurement results, the anti-redeposition performance is determined according to the following formula
Anti-redeposition performance(%)=(whiteness after washing)/(whiteness of original white cloth)×100.

US Pat. No. 10,766,990

TETRAFLUOROETHYLENE/HEXAFLUOROPROPYLENE COPOLYMERS INCLUDING PERFLUOROALKOXYALKYL PENDANT GROUPS AND METHODS OF MAKING AND USING THE SAME

3M Innovative Properties ...

1. A copolymer comprising tetrafluoroethylene units, hexafluoropropylene units, and units represented by formulain a range from 0.02 to 2 mole percent, based on the total amount of the copolymer, wherein n is from 1 to 6, m is 0 or 1, and Rf is a linear or branched perfluoroalkyl group having from 1 to 8 carbon atoms and optionally interrupted by one or more —O— groups, wherein the copolymer has a melt flow index in a range from 25 grams per 10 minutes to 35 grams per 10 minutes measured at a temperature of 372° C. and at a support weight of 5.0 kg, and wherein the copolymer comprises at least 25 parts per million alkali-metal cations.

US Pat. No. 10,766,971

SYSTEM FOR MAKING AND USING A COMPOSITION OF MATTER

Economy Mud Products Comp...

1. A system for making and using a ground product composition of matter, the system comprising:a reactor operated with a reaction temperature range of 120° F. to 180° F., wherein
a guar split and at least one reagent are fed to, and reacted within, the reactor to form a guar derivative;
a transfer and treatment section operably coupled with the reactor, wherein the guar derivative is treated and transferred;
a co-grinder operably associated with the transfer and treatment section, whereby the guar derivative is transferred thereto, wherein the co-grinder is further fed an acid, and wherein the co-grinder operates to grind the guar derivative and the acid together to form a ground product characterized by at least 90% by weight of a given quantity thereof having an average particle bulk diameter less than or equal to 74 microns;
a heated vacuum system operably associated with the co-grinder, the heated vacuum system comprising:
a combustion burner;
a dust collector configured for use as a dryer; and
a blower configured for pulling a vacuum.

US Pat. No. 10,766,970

MODIFIED CARBOHYDRATES, COMPOSITIONS COMPRISING THE SAME, AND METHODS OF MAKING AND USING THE SAME

Wake Forest University He...

1. A compound comprising at least one unit having a structure of Formula I:
wherein
Y is absent or a C1-C4 alkyl or C1-C4 alkenyl;
R1 is each independently selected from the group consisting of —H, —OH, —NH2, —COOH, —NO2, —CN, —Br, —Cl, —F, —C1-C6 alkylhalide, unsubstituted or substituted —C1-C6 alkyl, unsubstituted or substituted —C1-C6 alkenyl, —SO2H, —SO3H, —COCH3, —Si(OH)3, —SO2NH2, —PO(OR?)2, and —B(OH)2, wherein R? is unsubstituted or substituted alkyl, alkenyl, alkynyl, or aryl;
n is from 1 to 1,000,000; and
o is 1, 2, 3, 4, or 5,
wherein at least one R1 is in the para position and is selected from the group consisting of —NH2, —COOH, —NO2, —CN, —Br, —Cl, —F, —C1-C6 alkylhalide, unsubstituted or substituted —C1-C6 alkyl, unsubstituted or substituted —C1-C6 alkenyl, —SO2H, —SO3H, —COCH3, —Si(OH)3, —SO2NH2, —PO(OR?)2, and —B(OH)2, and wherein R? is unsubstituted or substituted alkyl, alkenyl, alkynyl, or aryl, and
wherein the compound is an alginate polymer.

US Pat. No. 10,766,964

COMPOSITIONS AND METHODS FOR TREATING AND PREVENTING INFLAMMATION

RSEM, LIMITED PARTNERSHIP...

1. A fusion polypeptide comprising a neuropilin-1 (NRP1) polypeptide consisting of an amino acid sequence having at least 90% identity with residues 22-424 of SEQ ID NO: 107, wherein said fusion polypeptide does not comprise the b2 and c domains of native human NRP1 and has a purification tag linked to said NRP1 polypeptide.

US Pat. No. 10,766,948

MONOCLONAL ANTIBODIES SPECIFIC FOR THE PIII ANTIGEN OF HUMAN ADENOVIRUS (ADV), PRODUCED AND SECRETED BY CELL HYBRIDOMAS, USEFUL FOR DETECTION AND DIAGNOSIS OF ADV INFECTION

PONTIFICIA UNIVERSIDAD CA...

1. A monoclonal antibody, or a fragment thereof, which binds to the pIII protein of Adenovirus (ADV), comprising a variable region of the heavy chain having a sequence with at least 90%, 95% or 99% identity with SEQ ID NO: 1 or SEQ ID NO: 5 and a variable region of the light chain having a sequence with at least 90%, 95% or 99% identity with SEQ ID NO: 2 or SEQ ID NO: 6.

US Pat. No. 10,766,925

OPIOID RECEPTOR MODULATORS

Arizona Board of Regents ...

1. A compound of the formula:whereinAr1 is H or optionally substituted heteroaryl;
R1 is a heteroalkyl;
R2 is alkyl;
R3 is an oligopeptide;
R4 is alkylene;
each of X1 is O, NR6 or S; and
each of R5 and R6 is independently H or alkyl.

US Pat. No. 10,766,922

SUBSTITUTED STEROIDS FOR THE TREATMENT OF CANCER

AQUAVAN TECHNOLOGY CO., L...

1. A method for inhibiting a cancer cell proliferation in a subject, comprising administering to a subject in need thereof a therapeutically effective amount of a pharmaceutical composition comprising a pharmaceutically acceptable carrier, a pharmaceutically acceptable diluent, a pharmaceutically acceptable excipient, and/or a pharmaceutically acceptable adjuvant and a compound represented by formula (vi):

US Pat. No. 10,766,921

PROCESS AND INTERMEDIATES FOR THE 6,7-ALPHA-EPOXIDATION OF STEROID 4,6-DIENES

NZP UK Limited, Bristol ...

1. A process for preparing a compound of general formula (Ia):and salts and isotopic variants thereofwherein:R2 is selected from the group consisting of H, halo, OH and a protected OH group;Y is selected from the group consisting of a bond, and a C1-20 alkylene, C2-20 alkenylene or C2-20 alkynylene linker group any of which is optionally substituted with one or more R3;wherein each R3 is independently selected from H, halo, OH, a protected OH group and NR8R9;
wherein each of R8 and R9 is independently selected from H, C1-6 alkyl, C(O)Ph, benzyl, phthalimide, tert-butyloxycarbonyl and carboxybenzyl;R4 is selected from the group consisting of C(O)OR10, OC(O)R10, C(O)NR10R11, OR10, OSi(R13)3, S(O)R10, SO2R10, OSO2R10, SO3R10, OSO3R10, halo, CN, C(O)R10, NR10R11, BR10R11, C(O)CH2N2, —CH?CH2, —C?CH, CH[C(O)OR10]2, CH(BR10R11)2, azide, NO2, NR10C(O)NR10SO2R11, NR10C(O)NR10SO2NR10R11, NR10SO2R11, C(O)NR10SO2R11, CH(XR10)(XR11), CH(R10)(XR11), phthalimide and a carboxylic acid mimetic group;wherein each X is independently selected from O, S and NR8;
wherein each R10 and R11 is independently selected from:
a. hydrogen;
and
b. C1-20 alkyl, C3-7 cycloalkyl, C2-20 alkenyl or C2-20 alkynyl, any of which is optionally substituted with one or more substituents selected from:
C1-4 alkyl, C1-4 haloalkyl, halo, NO2, CN, OR19, SR19, C(O)OR19, C(O)N(R19)2, SO2R19, OSO2R19, SO3R19, OSO3R19, N(R19)2 and a 6- to 14-membered aryl or 5- to 14-membered heteroaryl group, either of which is optionally substituted with one or more substituents selected from C1-6 alkyl, C1-6 haloalkyl, halo, NO2, CN, OR19, SR19, C(O)OR19, C(O)N(R19)2, SO2R19, SO3R19 and N(R19)2;
and
c. a 6- to 14-membered aryl, 5- to 14-membered heteroaryl group or 3- to 10-membered heterocyclic ring, any of which is optionally substituted with one or more substituents selected from:
C1-6 alkyl, C3-7 cycloalkyl, C1-6 haloalkyl, halo, NO2, CN, OR19, C?O, C(O)C1-4alkyl, SR19, C(O)OR19, C(O)N(R19)2, SO2R19, SO3R19, N(R19)2, phenyl, 5- to 14-membered heteroaryl, 3- to 10-membered heterocyclic ring, methylenedioxy and ethylenedioxy;
and
d. a polyethylene glycol residue;
or
e. when R4 is selected from C(O)NR10R11, CH(XR10)(XR11), CH(R10)(XR11), NR10R11, BR10R11, CH[C(O)OR10]2 and CH(BR10R11)2, an R10 and an R11 group, together with the atom or atoms to which they are attached, may combine to form a 3- to 10-membered heterocyclic ring;
wherein each R19 is independently selected from:
H, C1-6 alkyl, C1-6 haloalkyl, and a 6- to 14-membered aryl or 5- to 14-membered heteroaryl group either of which is optionally substituted with one or more substituents selected from halo, C1-6 alkyl and C1-6 haloalkyl;
and wherein each R13 is independently selected from:
a. C1-20 alkyl, C2-20 alkenyl or C2-20 alkynyl, any of which is optionally substituted with one or more substituents selected from:
halo, NO2, CN, OR19, SR19, C(O)OR19, C(O)N(R19)2, SO2R19, SO3R19, OSO3R19, N(R19)2 and a 6- to 14-membered aryl or 5- to 14-membered heteroaryl group, either of which is optionally substituted with one or more substituents selected from C1-6 alkyl, C1-6 haloalkyl, halo, NO2, CN, OR19, SO2R19, SO3R19 and N(R19)2;
and
b. a 6- to 14-membered aryl or 5- to 14-membered heteroaryl group either of which is optionally substituted with one or more substituents selected from:
C1-6 alkyl, C1-6 haloalkyl, halo, NO2, CN, OR19, SR19, C(O)OR19, C(O)N(R19)2, SO2R19, SO3R19 and N(R19)2;
wherein each R19 is independently selected from:
H, C1-6 alkyl and C1-6 haloalkyl; orY and R4 together form a=CH2 group; andR5 is selected from H, OH or a protected OH group;comprising:oxidation of a compound of general formula (IIa) or a salt or isotopic variant thereofusing an oxidant and methyltrioxorhenium as catalyst:wherein R2, R4, R5 and Y are as defined for compounds of general formula (Ia).

US Pat. No. 10,766,919

CYCLIC DI-NUCLEOTIDE COMPOUNDS AS STING AGONISTS

1. A method of inducing e-STING-dependent type I interferon production in a subject, said method comprising administering a therapeutically effective amount of a compound selected from the group consisting of a compound of formula (I?) to the subject, wherein the compound of formula (I?) is:or a pharmaceutically acceptable salt thereof, whereinBase1 and Base2 are each independently selected from the group consisting of
where Base1 and Base2 each may be independently substituted by 0-3 substituents R10, where each R10 is independently selected from the group consisting of F, Cl, I, Br, OH, SH, NH2, C1-3alkyl, C3-6cycloalkyl, O(C1-3 alkyl), O(C3-6 cycloalkyl), S(C1-3 alkyl), S(C3-6cycloalkyl), NH(C1-3 alkyl), NH(C3-6 cycloalkyl), N(C1-3 alkyl)2, and N(C3-6 cycloalkyl)2,Y and Ya are each independently selected from the group consisting of —O— and —S—;
Xa and Xa1 are each independently selected from the group consisting of O, and S;
Xb and Xb1 are each independently selected from the group consisting of O, and S;
Xc and Xc1 are each independently selected from the group consisting of OR9, SR9, and NR9R9;
Xd and Xd1 are each independently selected from the group consisting of O and S;
R1 and R2 are each independently selected from the group consisting of H, F, Cl, Br, I, OH, CN, N3, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 haloalkyl, C2-C6 haloalkenyl, C2-C6 haloalkynyl, —O—C1-C6 alkyl, —O—C2-C6 alkenyl, and —O—C2-C6 alkynyl, where said R1 and R1a C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 haloalkyl, C2-C6 haloalkenyl, C2-C6 haloalkynyl, —O—C1-C6 alkyl, —O—C2-C6 alkenyl, and —O—C2-C6 alkynyl are substituted by 0 to 3 substituents selected from the group consisting of F, Cl, Br, I, OH, CN, and N3;
R2 and R2a are each independently selected from the group consisting of H, F, Cl, Br, I, OH, CN, N3, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 haloalkyl, C2-C6 haloalkenyl, C2-C6 haloalkynyl, —O—C1-C6 alkyl, —O—C2-C6 alkenyl, and —O—C2-C6 alkynyl, where said R2 and R2a C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 haloalkyl, C2-C6 haloalkenyl, C2-C6 haloalkynyl, —O—C1-C6 alkyl, —O—C2-C6 alkenyl, and —O—C2-C6 alkynyl are substituted by 0 to 3 substituents selected from the group consisting of F, Cl, Br, I, OH, CN, and N3;
R3 is selected from the group consisting of H, F, Cl, Br, I, OH, CN, N3, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 haloalkyl, C2-C6 haloalkenyl, C2-C6 haloalkynyl, —O—C1-C6 alkyl, —O—C2-C6 alkenyl, and —O—C2-C6 alkynyl, where said R3 C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 haloalkyl, C2-C6 haloalkenyl, C2-C6 haloalkynyl, —O—C1-C6 alkyl, —O—C2-C6 alkenyl, and —O—C2-C6 alkynyl are substituted by 0 to 3 substituents selected from the group consisting of F, Cl, Br, I, OH, CN, and N3;
R4 and R4a are each independently selected from the group consisting of H, F, Cl, Br, I, OH, CN, N3, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 haloalkyl, C2-C6 haloalkenyl, C2-C6 haloalkynyl, —O—C1-C6 alkyl, —O—C2-C6 alkenyl, and —O—C2-C6 alkynyl, where said R4 and R4a C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 haloalkyl, C2-C6 haloalkenyl, C2-C6 haloalkynyl, —O—C1-C6 alkyl, —O—C2-C6 alkenyl, and —O—C2-C6 alkynyl are substituted by 0 to 3 substituents selected from the group consisting of F, Cl, Br, I, OH, CN, and N3;
R5 is selected from the group consisting of H, F, Cl, Br, I, OH, CN, NH2, N3, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 haloalkyl, C2-C6 haloalkenyl, C2-C6 haloalkynyl, —O—C1-C6 alkyl, —O—C2-C6 alkenyl, and —O—C2-C6 alkynyl, where said R5 C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 haloalkyl, C2-C6 haloalkenyl, C2-C6 haloalkynyl, —O—C1-C6 alkyl, —O—C2-C6 alkenyl, and —O—C2-C6 alkynyl are substituted by 0 to 3 substituents selected from the group consisting of F, Cl, Br, I, OH, CN, NR9R9, and N3;
R6 and R6a are each independently selected from the group consisting of H, F, Cl, Br, I, OH, CN, N3, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 haloalkyl, C2-C6 haloalkenyl, C2-C6 haloalkynyl, —O—C1-C6 alkyl, —O—C2-C6 alkenyl, and —O—C2-C6 alkynyl, where said R6 and R6a C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 haloalkyl, C2-C6 haloalkenyl, C2-C6 haloalkynyl, —O—C1-C6 alkyl, —O—C2-C6 alkenyl, and —O—C2-C6 alkynyl are substituted by 0 to 3 substituents selected from the group consisting of F, Cl, Br, I, OH, CN, and N3;
R7 and R7a are each independently selected from the group consisting of H, F, Cl, Br, I, OH, CN, N3, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 haloalkyl, C2-C6 haloalkenyl, C2-C6 haloalkynyl, —O—C1-C6 alkyl, —O—C2-C6 alkenyl, and —O—C2-C6 alkynyl, where said R7 and R7a C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 haloalkyl, C2-C6 haloalkenyl, C2-C6 haloalkynyl, —O—C1-C6 alkyl, —O—C2-C6 alkenyl, and —O—C2-C6 alkynyl are substituted by 0 to 3 substituents selected from the group consisting of F, Cl, Br, I, OH, CN, and N3;
R8 and R8a are each independently selected from the group consisting of H, F, Cl, Br, I, OH, CN, N3, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 haloalkyl, C2-C6 haloalkenyl, C2-C6 haloalkynyl, —O—C1-C6 alkyl, —O—C2-C6 alkenyl, and —O—C2-C6 alkynyl, where said R8 and R8a C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 haloalkyl, C2-C6 haloalkenyl, C2-C6 haloalkynyl, —O—C1-C6 alkyl, —O—C2-C6 alkenyl, and —O—C2-C6 alkynyl are substituted by 0 to 3 substituents selected from the group consisting of F, Cl, Br, I, OH, CN, and N3;
each R9 is independently selected from the group consisting of H, C1-C20 alkyl,
where each R9 C1-C20 alkyl is optionally substituted by 0 to 3 substituents independently selected from the group consisting of OH, —O—C1-C20 alkyl, —S—C(O)C1-C6 alkyl, and C(O)OC1-C6 alkyl;optionally R1a and R3 are connected to form C1-C6 alkylene, C2-C6 alkenylene, C2-C6 alkynylene, —O—C1-C6 alkylene, —O—C2-C6 alkenylene, or —O—C2-C6 alkynylene, such that where R1a and R3 are connected to form —O—C1-C6 alkylene, —O—C2-C6 alkenylene, or —O—C2-C6 alkynylene, said O is bound at the R3 position;
optionally R2a and R3 are connected to form C1-C6 alkylene, C2-C6 alkenylene, C2-C6 alkynylene, —O—C1-C6 alkylene, —O—C2-C6 alkenylene, or —O—C2-C6 alkynylene, such that where R2a and R3 are connected to form —O—C1-C6 alkylene, —O—C2-C6 alkenylene, or —O—C2-C6 alkynylene, said O is bound at the R3 position;
optionally R3 and R6a are connected to form —O—C1-C6 alkylene, —O—C2-C6 alkenylene, or —O—C2-C6 alkynylene, such that where R3 and R6a are connected to form —O—C1-C6 alkylene, —O—C2-C6 alkenylene, or —O—C2-C6 alkynylene, said O is bound at the R3 position;
optionally R4 and R5 are connected to form are connected to form C1-C6 alkylene, C2-C6 alkenylene, C2-C6 alkynylene, —O—C1-C6 alkylene, —O—C2-C6 alkenylene, or —O—C2-C6 alkynylene, such that where R4 and R5 are connected to form —O—C1-C6 alkylene, —O—C2-C6 alkenylene, or —O—C2-C6 alkynylene, said O is bound at the R5 position;
optionally R5 and R6 are connected to form —O—C1-C6 alkylene, —O—C2-C6 alkenylene, or —O—C2-C6 alkynylene, such that where R5 and R6 are connected to form —O—C1-C6 alkylene, —O—C2-C6 alkenylene, or —O—C2-C6 alkynylene, said O is bound at the R5 position;
optionally R7 and R8 are connected to form C1-C6 alkylene, C2-C6 alkenylene, or C2-C6 alkynylene; and
optionally R7a and R8a are connected to form C1-C6 alkylene, C2-C6 alkenylene, or C2-C6 alkynylene; and
with the provisos that
(a) when Y and Ya are each O, Xa and Xa1 are each O, Xb and Xb1 are each O, and Xc and Xc1 are each OH or SH, Xd and Xd1 are each O, R1 and R1a are each H, R2 is H, R6 and R6a are each H, R7 and R7a are each H, R8 and R8a are each H, and Base1 and Base2 are each selected from the group consisting of
then R5 and R3 are not both selected from the group consisting of H, F and OH; and(b) the compound is not selected from the group consisting of

US Pat. No. 10,766,918

MODIFIED OLIGONUCLEOTIDES AND METHODS FOR THEIR SYNTHESIS

Noogen LLC, Novosibirsk ...

1. A compound of Formula (I)
wherein
Z is selected from —O?, —S?, —Se?, —(N?)RN, or a protecting group (PG);
X is selected from the 5?-O— of a nucleoside or oligonucleotide and Y is selected from the 3?-O— of a nucleoside oligonucleotide; —H, —OH, —SH, —NHRN, —O-PG, or —S-PG, wherein PG is a protecting group; a linker, a monophosphate or diphosphate, or a label or quencher;
or
Y is selected from the 3?-O— of a nucleoside or oligonucleotide and X is selected from the 5?-O— of a nucleoside, oligonucleotide, —H, —OH, —SH, —NHRN, —O-PG, or —S-PG, wherein PG is a protecting group; a linker, a monophosphate or diphosphate, or a label or quencher;
R1 is selected from —NR1AR1B, —OR3, —SR3, —H, —S(O)H, —S(O)R3, —S(O)2H, —S(O)2R3, —S(O)2NH2, —S(O)2NHR3, —S(O)2NR32, —C1-10alkyl, —C2-10alkenyl, —C2-10alkynyl, or —C6-10 aryl;
R2 is selected from —H, —NR2AR2B, —OR3, —SR3, —CN, —S(O)H, —S(O)R3, —S(O)2H, —S(O)2R3, —S(O)2NH2, —S(O)2NHR3, —S(O)2NR32, —C1-10alkyl, —C2-10alkenyl, —C2-10alkynyl, or —C6-10aryl;
wherein each R1A, R1B, R2A, and R2B is independently selected from —H, —C1-10alkyl, —C2-10alkenyl, —C2-10alkynyl, or —C6-10aryl;
optionally, wherein R1A and R2A together form an alkylene chain of 2-4 atoms in length;
optionally, wherein R1A and R1B, together with the atom to which they are bound, form a 5-8 membered heterocyclic substituent moiety, selected from the group consisting of N-pyrrolidinyl, N-piperidinyl, N-azepanyl, or N-azocanyl;
optionally, wherein R2A and R2B, together with the atom to which they are bound, form a 5-8 membered heterocyclic substituent moiety, selected from the group consisting of N-pyrrolidinyl, N-piperidinyl, N-azepanyl, or N-azocanyl;
R3 is selected from —C1-10alkyl, —C2-10alkenyl, —C2-10alkynyl, or —C6-10aryl;
wherein the linker is selected from the group consisting of succinyl, diglycolyl, oxalyl, hydroquinone-O,O?-diacetyl (Q-linker), phthaloyl, 4,5-dichlorophthaloyl, malonyl, glutaryl, diisopropylsilyl and 1,1,3,3-tetraisopropyldisiloxane-1,3-diyl, or dodecane-12-oxy-1-phosphatidyl,
the label is fluorescein-derived substituent,
the quencher is 2-((2-hydroxy-ethyl)-{4-[2-methoxy-5-methyl-4-(4-methyl-2-nitro-phenylazo)-phenylazo]-phenyl}-amino)-ethanol-derived substituent;
wherein RN is —H or —C1-4alkyl; and
when Z is PG, the compound is a salt with anion counterpart selected from the group consisting of I?, Br?, Cl?, N-succinimido ((CH2)2(CO)2N?), CCl3?, CBr3?, CI3?, CHI2?, trifluoromethanesulfonate (CF3SO3?), p-toluenesulphonate (C7H7SO3?), dichlorophosphate (PO2Cl2?), perchlorate (ClO4?), tetrafluoroborate (BF4?), tetraphenylborate (BPh4?), or hexafluorophosphate (PF6?).

US Pat. No. 10,766,917

NUCLEOTIDES FOR THE TREATMENT OF CANCER

IDENIX PHARMACEUTICALS LL...

1. A compound according to Formula I:
or a pharmaceutically acceptable salt thereof, wherein:
Base is a nucleobase:
X is O or S;
V is hydrogen, halogen or amino;
Z1 is halogen;
Z2 is halogen;
R1 and R2 together with the two oxygen atoms to which they are attached form the ring:

R8 is C1-10alkylcarbonylthioC1-10alkoxy,

R9 is C1-10alkyl, C3-10cycloalkyl, aryl or arylC1-6alkyl;
R10 is C1-10alkyl or COOR9;
R11 is C1-10alkylcarbonyloxyC1-10alkyl, C3-10cycloalkylcarbonyoxy, aryl, aryloxy, C1-10alkylaryl, arylC1-10alkyl, heteroaryl, heteroarylC1-10alkyl or C1-10alkylheteroaryl;
Rz is C2-11alkenyl, C2-11alkynyl, C1-10alkoxycarbonylC1-10alkyl, C1-10alkylcarbonylthioC1-10alkyl, C1-10alkyldisulfideC1-6alkyl, aryl or heteroarylC1-10alkyl, wherein alkyl is optionally substituted by one, two or three substituents independently selected from halogen and hydroxy, and heteroaryl is substituted by one or two substituents selected from C1-10 alkyl and nitro; and
W is O or S.

US Pat. No. 10,766,916

E-SELECTIN ANTAGONIST COMPOUNDS, COMPOSITIONS, AND METHODS OF USE

GLYCOMIMETICS, INC., Roc...

1. A pharmaceutically acceptable salt of:

US Pat. No. 10,766,915

METAL-BASED COORDINATION COMPLEXES AS PHOTODYNAMIC COMPOUNDS AND THEIR USE

1. A compound having the formula (V)
including hydrates, solvates, pharmaceutically acceptable salts, prodrugs and complexes thereof, wherein:
M is selected from the group consisting of osmium, manganese, molybdenum, rhenium, ruthenium, iron, cobalt, rhodium, iridium, nickel, and platinum;
X is selected from the group consisting of Cl?, PF6?, Br?, BF4?, ClO4?, CF3SO3?, and SO4?2;
n=0, 1, 2, 3, 4, or 5;
Lig3 is a bidentate ligand that at each occurrence is each independently selected from the group consisting of

R3a, R3b, R3c, R3d, R3e, R3f, R3g, R3h, R3i, R3j, R3k, and R3l at each occurrence are each independently selected from the group consisting of hydrogen, C1-6 optionally substituted alkyl, C1-6 optionally substituted branched alkyl, C1-6 optionally substituted haloalkyl, C1-6 optionally substituted alkoxy, optionally substituted phenyl, and CO2R8;
R8 at each occurrence is independently selected from the group consisting of hydrogen and optionally substituted alkyl;
wherein: (a) the compound is not Os(biq)3(ClO4)2·H2O, where biq is 2,2?-biquinoline, and (b) when M is ruthenium: (i) no more than two substituents on M are identical, and (ii) no more than one substituent on M is 2,2?-biquinoline.

US Pat. No. 10,766,914

DNA ALKYLATING AGENTS

OBI PHARMA, INC., Taipei...

1. A method of treating cancer expressing AKR1C3 reductase, comprising:administering to a patient in need thereof a therapeutically effective amount of a compound of formula I or a composition comprising the compound and at least a pharmaceutically acceptable excipient or carrier thereby treating the cancer

or a pharmaceutically acceptable salt, or a solvate of each thereof, wherein
X10 is O, S, SO, or SO2;
A is C6-C10 aryl, 5-15 membered heteroaryl, or —N?CR1R2;
each R1 and R2 independently is hydrogen, —CN, C1-C6 alkyl, C3-C8 cycloalkyl, C6-C10 aryl, 4-15 membered heterocycle, 5-15 membered heteroaryl, ether, —CONR13R14, or —NR13COR14;
each X and Z independently is hydrogen or C1-C6 alkyl;
Y is hydrogen, halo, or C1-C6 alkyl;
R is hydrogen or C1-C6 alkyl;
each R13 and R14 independently is hydrogen, C1-C6 alkyl, C3-C8 cycloalkyl, C6-C10 aryl, 4-15 membered heterocycle, 5-15 membered heteroaryl, or ether;
T is OP(Z1)(NHCH2CH2Cl)2, OP(Z1)(NHCH2CH2Br)2, OP(Z1)(NH2)(N(CH2CH2X1)2), OP(Z1)(N(CH2)2)2, or OP(Z1)(N(CH2CH2Cl)2)2, wherein Z1 is O or S, and X1 is Cl, Br, or OMs; and
wherein the alkyl, cycloalkyl, aryl, heterocycle, heteroaryl, ether groups are optionally substituted, and wherein the cancer is selected from the group consisting of a cancer of the adrenal gland, bone, brain, breast, bronchi, colon and/or rectum, gallbladder, head and neck, kidneys, larynx, liver, lung, neural tissue, pancreas, prostate, parathyroid, skin, stomach, and thyroid; and acute and chronic lymphocytic and granulocytic tumors, adenocarcinoma, adenoma, basal cell carcinoma, cervical dysplasia and in situ carcinoma, Ewing's sarcoma, epidermoid carcinomas, giant cell tumor, glioblastoma multiforma, hairy-cell tumor, intestinal ganglioneuroma, hyperplastic corneal nerve tumor, islet cell carcinoma, Kaposi's sarcoma, leiomyoma, leukemias, lymphomas, malignant carcinoid, malignant melanomas, malignant hypercalcemia, marfanoid habitus tumor, medullary carcinoma, metastatic skin carcinoma, mucosal neuroma, myeloma, mycosis fungoides, neuroblastoma, osteo sarcoma, osteogenic and other sarcoma, ovarian tumor, pheochromocytoma, polycythermia vera, primary brain tumor, small-cell lung tumor, squamous cell carcinoma of both ulcerating and papillary type, hyperplasia, seminoma, soft tissue sarcoma, retinoblastoma, rhabdomyo sarcoma, renal cell tumor, topical skin lesion, veticulum cell sarcoma, and Wilm's tumor.

US Pat. No. 10,766,912

SILICON-CONTAINING COMPOUND FOR RESISTANCE TO HEPATITIS C VIRUS INFECTION

Chia Tai Tianqing Pharmac...

1. A compound of Formula I, a pharmaceutically acceptable salt, a tautomer, a stereoisomer or a deuteride thereof, or a mixture thereof:
wherein:
R1 and R2 are each independently selected from the group consisting of hydroxyl, alkyl, alkoxy and aryl, or R1 and R2 are joined to form a silicon-containing saturated aliphatic ring containing 1, 2 or 3 silicon atoms;
R3, R4, R5 and R6 are each independently selected from the group consisting of hydrogen and halogen;
X is selected from the group consisting of the following groups:

Y is selected from the group consisting of the following groups:

R7 and R8 are each independently selected from the group consisting of —CH(alkyl)(alkoxy), —CH(alkyl)2, —CH(alkoxy)2, —C(alkyl)2(alkoxy), —C(alkyl)(alkoxy)2, —C(alkyl)3 and —C(alkoxy)3;
R9 and R10 are each independently selected from the group consisting of hydrogen, halogen, alkyl, alkoxy, and alkoxyalkyl;
each of Ra and Rb is independently selected from the group consisting of hydrogen, halogen, and alkyl;
each m is independently selected from the group consisting of 0, 1, 2, 3, and 4; and
n is selected from the group consisting of 0, 1, 2, 3, 4, 5, 6, 7, and 8.

US Pat. No. 10,766,910

NITROGEN-CONTAINING COMPOUND AND COLOR CONVERSION FILM COMPRISING SAME

LG CHEM, LTD., Seoul (KR...

1. A compound represented by the following Chemical Formula 1:
in Chemical Formula 1,
p is 2, and structures in the parenthesis are the same as each other,
L1 and L2 are the same as or different from each other, and are each independently a direct bond; —SiR101R102—; —SO2—; —O—; —NR103—; —C(?O)O—; a substituted or unsubstituted alkylene group; a substituted or unsubstituted cycloalkylene group; a substituted or unsubstituted arylene group; or a substituted or unsubstituted divalent heterocyclic group,
R1 and R2 are the same as or different from each other, and are each independently hydrogen; deuterium; a halogen group; a cyano group; a nitro group; a carbonyl group; a carboxyl group (—COOH); an ether group; a hydroxy group; —C(?O)NR104R105; —C(?O)OR106; a substituted or unsubstituted alkyl group; a substituted or unsubstituted cycloalkyl group; a substituted or unsubstituted alkoxy group; a substituted or unsubstituted aryloxy group; a substituted or unsubstituted alkenyl group; a substituted or unsubstituted silyl group; a substituted or unsubstituted amine group; a substituted or unsubstituted alkylamine group; a substituted or unsubstituted arylamine group; a substituted or unsubstituted aryl group; or a substituted or unsubstituted heterocyclic group, or adjacent groups are optionally bonded to each other to form a ring,
m is an integer of 0 to 4, and when m is 2 or more, R1's are the same as or different from each other,
n is an integer of 0 to 5, and when n is 2 or more, R2's are the same as or different from each other,
X1 and X2 are the same as or different from each other, and are each independently a halogen group; a cyano group; an ether group; an ester group; a substituted or unsubstituted alkyl group; a substituted or unsubstituted alkynyl group; a substituted or unsubstituted alkoxy group;
a substituted or unsubstituted aryloxy group; a substituted or unsubstituted aryl group; or a substituted or unsubstituted heterocyclic group, or X1 and X2 are bonded to each other to form a substituted or unsubstituted ring, and
R101 to R106 are the same as or different from each other, and are each independently hydrogen; deuterium; a substituted or unsubstituted alkyl group; a substituted or unsubstituted fluoroalkyl group; a substituted or unsubstituted aryl group; or a substituted or unsubstituted heterocyclic group.

US Pat. No. 10,766,907

CRYSTALLINE FORMS OF THERAPEUTIC COMPOUNDS AND USES THEREOF

Kala Pharmaceuticals, Inc...

1. A method of treating a disease comprising administering to a subject in need thereof a therapeutically effective amount of a pharmaceutical composition comprising a crystalline form of Compound 1:
wherein the crystalline form has an X-ray powder diffraction (XRPD) pattern comprising peaks at 8.5-9.5 degrees 2?, 18-19 degrees 2?, 19-19.5 degrees 2?, and 25.0-25.5 degrees 2?; and
wherein the disease is a proliferative disease, cancer, or an ocular disease.

US Pat. No. 10,766,906

FUSED HEXACYCLIC IMIDAZOLE DERIVATIVES AS MODULATORS OF TNF ACTIVITY

UCB Biopharma SRL, Bruss...

1. A compound of formula (I) or an N-oxide thereof, or a pharmaceutically acceptable salt thereof:whereinA represents C—R6;
B represents C—R7;
D represents C—R8;
—(X-M-Q)- represents an optionally substituted five-membered heteroaromatic ring selected from pyrrolyl, pyrazolyl, imidazolyl, triazolyl and tetrazolyl optionally substituted by one, two or three substituents selected from C1-6 alkyl, trifluoromethyl, hydroxy and oxo;
Z represents methylene;
E represents a fused heteroaromatic ring system of formula (Ea)
wherein the asterisks (*) represent the site of attachment of E to the remainder of the molecule;R1 represents chloro; or R1 represents pyrimidinyl, cyclobutylpyridinyl, cyclopentylpyridinyl, cyclobutylpyrimidinyl, azetidinylpyrimidinyl or piperazinyl-pyrimidinyl, any of which groups may be optionally substituted by one two or three substituents independently selected from halogen, trifluoromethyl, hydroxy, hydroxy(C1-6)alkyl, oxo, amino and amino(C1-6)alkyl;
R2 represents hydrogen or halogen;
R3 and R4 independently represent hydrogen, halogen or or C1-6 alkyl;
R5 represents difluoro-methoxy or methoxy;
R6 represents hydrogen, halogen or trifluoromethyl;
R7 represents hydrogen or trifluoromethyl;
R8 represents hydrogen or trifluoromethyl; and
R12 represents hydrogen or C1-6 alkyl.

US Pat. No. 10,766,901

PREPARATION METHOD FOR CHIRAL PYRROLOPYRIMIDINE COMPOUND

CHIA TAI TIANQING PHARMAC...

1. A method for preparing a compound of formula I, comprising reacting a compound of formula A with a compound of formula 6 or a salt thereof to obtain a compound of formula 7 or a compound of formula 14, and preparing the compound of formula I from the compound of formula 7 or the compound of formula 14:
wherein R1 is selected from the group consisting of H and an amino-protecting group; and RA is selected from the group consisting of H and CH3.

US Pat. No. 10,766,900

BARICITINIB INTERMEDIATE, METHOD FOR FORMING BARICITINIB INTERMEDIATE, AND METHOD FOR PREPARING BARICITINIB OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF

FORMOSA LABORATORIES, INC...

1. A method for forming a compound of formula (1):
wherein R1 is CH2OC(O)R?, R? is a substituted or unsubstituted alkyl group or a substituted or unsubstituted cycloalkyl group, and R2 is selected from the group consisting of substituted or unsubstituted cyclic ether group, 1-(ethoxy)ethyl group, p-methoxybenzyl group, triphenylmethyl group, diphenylmethyl group, hydroxymethyl group, methoxymethyl group, triisopropylsilyl group and t-butyldimethylsilylmethyl group, comprising:
reacting a compound of formula (2) with a boron-containing compound selected from the group consisting of a compound of formula (3), a compound of formula (4) and a compound of formula (5) in the presence of bis(triphenylphosphine)palladium(II) dichloride (Pd(PPh3)2Cl2) and in the absence of an additional phosphine ligand, wherein the formula (2), the formula (3), the formula (4), and the formula (5) are as follows:

wherein X is selected from the group consisting of Br, Cl, and I; and R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, R13 and R14 are each independently H or C1-C4 alkyl group.

US Pat. No. 10,766,899

METHODS FOR PREPARING SUBSTITUTED IMIDAZO[4,5-B]PYRAZINES

CYTOKINETICS, INCORPORATE...

1. A method of producing a compound of Formula 201:
wherein:
R1 is selected from halogen, mesyloxy, p-nitrobenzenesulfonyloxy and tosyloxy;
R4 is hydrogen; and
R2 is selected from pentan-3-yl, heptan-4-yl, 4-methyl-1-morpholinopentan-2-yl, isobutyl, cyclohexyl, cyclopropyl, sec-butyl, tert-butyl, isopropyl, 1-hydroxybutan-2-yl, tetrahydro-2H-pyran-4-yl, 1-methoxybutan-2-yl, 1-aminobutan-2-yl and 1-morpholinobutan-2-yl;
the method comprising:
(a) treating a compound of Formula 101:

wherein X is halogen;
with an amine of formula R2—NH2 in a suitable solvent to produce a compound of Formula 102:

and
(b) treating the compound of Formula 102 with a di-activated carbonyl equivalent selected from carbonyl diimidazole, phosgene and triphosgene in a suitable solvent to produce the compound of Formula 201.

US Pat. No. 10,766,898

THERAPEUTIC COMPOUND FOR PAIN AND SYNTHESIS THEREOF

Janssen Pharmaceutica NV,...

1. A compound of Formula XXIII(A):
wherein R2 is selected from the group consisting of hydrogen, C(O)R? wherein R? is CH2OCH3, or pyridine optionally substituted with halo;
wherein R3 is selected from the group consisting of hydrogen, BOC, optionally substituted phenyl, or methylbenzodioxole; and
wherein R4 is hydrogen, alkyl, or cycloalkyl, or a stereoisomer, pharmaceutically acceptable salt, or mixture thereof.

US Pat. No. 10,766,897

IMIDAZO[4,5-C]PYRIDINE AND PYRROLO[2,3-C]PYRIDINE DERIVATIVES AS SSAO INHIBITORS

PROXIMAGEN, LLC, Plymout...

1. A process for the preparation of a compound of formula (I) or a pharmaceutically acceptable salt, or N-oxide thereofcomprising reacting a compound of formula (IIIb) with a compound of formula (IX) to form the compound of formula (I)
wherein:
Y is selected from hydrogen, hydroxyl, —NH2, —NH—C1-4-alkyl, —NH-halo-C1-4-alkyl, and —C1-4-alkoxy;
Z is selected from hydrogen, halogen, hydroxyl, cyano, C1-4-alkyl, halo-C1-4-alkyl, C1-4-alkoxy, halo-C1-4-alkoxy, —CONH2, —SO2NH2, —NH2, —NHC1-4-alkyl, and —NHhalo-C1-4-alkyl;
R1 is a phenyl ring, or a 5 or 6-membered heteroaryl ring, the ring being optionally substituted with one or more substituents selected from halogen, cyano, C1-4-alkyl, halo-C1-4-alkyl, cyano-C1-4-alkyl, a 3-7 membered cycloalkyl ring, —OR5, —NR6C(O)OR5, —NR6C(O)R5, —NR6C(O)NR4AR4B, —C(O)NR4AR4B, —C(O)R5, —C(O)OR5, and —NR6S(O)2R5;
R4A, R4B, R5, and R6 are each independently selected from hydrogen, C1-4-alkyl, and halo-C1-4-alkyl, or
R4A and R4B together with the nitrogen to which they are attached form a 3-7 membered cyclic amino group, optionally substituted by one or more substituents selected from halogen, hydroxyl, cyano, C1-4-alkyl, halo-C1-4-alkyl, C1-4-alkoxy, halo-C1-4-alkoxy, —CONH2, —SO2NH2, —NH2, —NHC1-4-alkyl, and —NHhalo-C1-4-alkyl;
X is —C(R2)?;
R2 is selected from hydrogen, halogen, cyano, C1-4-alkyl, halo-C1-4-alkyl, cyano-C1-4-alkyl, —OR5, —NR4AR4B, —NR6C(O)OR5, —NR6C(O)R5, —NR6C(O)NR4AR4B, —SO2R5, —SO2NR4AR4B and —NR6S(O)2R5;
W is a phenyl ring or a 5 or 6-membered heteroaryl ring, the ring being optionally substituted with one or more substituents selected from halogen, cyano, oxo C1-4-alkyl, halo-C1-4-alkyl, cyano-C1-4-alkyl, —OR5, —NR7AR7B, —NR6C(O)OR5, —NR6C(O)R5, —NR6C(O)NR7AR7B, —C(O)NR7AR7B, —C(O)R5, —C(O)OR5, —SO2R5, —SO2NR7AR7B, and —NR6S(O)2R5;
R7A and R7B are independently hydrogen, C1-4-alkyl, or halo-C1-4-alkyl;
V is selected from a bond, —O—, —N(R6)—, —(C?O)—, —CONR6—, —NR6C(O)—, and —C1-4-alkylene-, wherein the C1-4-alkylene group is optionally substituted by halogen, and wherein any one of the carbon atoms of the C1-4-alkylene group may be replaced by —O— or —N(R6)—;
R3 is selected from hydrogen, —C1-4-alkyl, —C1-4-alkyl-C1-4-alkoxy, a 3-7 membered heterocyclic ring, a 3-7 membered cycloalkyl ring, and a 5 or 6-membered heteroaryl ring, any one of the rings being optionally substituted with one or more substituents selected from halogen, oxo, hydroxyl, cyano, C1-4-alkyl, halo-C1-4-alkyl, cyano-C1-4-alkyl, —OR5, —NR4AR4B, —NR6C(O)OR5, —NR6C(O)R5, —NR6C(O)NR4AR4B, —C(O)NR4AR4B, —C(O)R5, —C(O)OR5, —SO2R5, —SO2NR4AR4B, and —NR6S(O)2R5;
provided that groups —WVR3 and/or R1 are not:
wherein:n is 0, 1, or 2;
R? and R? are independently selected from the group consisting of H, —C1-C6 alkyl, —(C?O)—C1-C6 alkyl, and —(C?O)OC(CH3)3; and
R?? is H, OH, or C1-C6 alkyl; and
further provided that when —R3 is H, R1 is not a phenyl ring substituted with one —OCH3.

US Pat. No. 10,766,896

IMIDAZO[4,5-C] RING COMPOUNDS CONTAINING GUANIDINE SUBSTITUTED BENZAMIDE GROUPS

3M INNOVATIVE PROPERTIES ...

1. A compound of the Formula (I):wherein:R3 and R4 are taken together to form a fused benzene ring, a fused pyridine ring, a fused cyclohexene ring, or a fused tetrahydropyridine ring; wherein the fused benzene ring, fused pyridine ring, fused cyclohexene ring, or fused tetrahydropyridine ring is either unsubstituted or substituted by one or more R groups;
R is selected from the group consisting of halogen, hydroxyl, alkyl, alkoxy, haloalkyl, —C(O)—O-alkyl, —C(O)—O—CH2Ph, —C(O)—O-aryl, amino, alkylamino, and dialkylamino aryl, arylalkylenyl, aryloxyalkylenyl, arylalkyleneoxy, aryloxy, heteroaryl, heteroarylalkylenyl, heteroaryloxyalkyenyl, heteroarylalkyleneoxy, and heteroaryloxy, wherein the alkyl, aryl, arylalkylenyl, aryloxyalkylenyl, arylalkyleneoxy, aryloxy, heteroaryl, heteroarylalkylenyl, heteroaryloxyalkyenyl, heteroaryalkyleneoxy, and heteroaryloxy groups can be unsubstituted or substituted by one or more substituents independently selected from the group consisting of alkyl, alkoxy, halogen, haloalkyl, hydroxyl, hydroxyalkylenyl, alkoxyalkylenyl, arylalkyleneoxy, and nitrile;
W is selected from the group consisting of a covalent bond, —O—, and NH—;
X is selected from the group consisting of alkylene, alkenylene, and alkynylene, wherein any of the alkylene, alkenylene, and alkynylene groups can be optionally interrupted or terminated by arylene or heteroarylene and optionally interrupted by one or more —O— groups;
R9 is -Q-N(R7)—C(?N—R5)—N(H)R6;
Q is selected from the group consisting of a covalent bond and alkylene;
R2 is selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, —O-alkyl, hydroxyalkylenyl, alkoxyalkylenyl, alkylaminoalkylenyl, hydroxyl, —CH2—NH—O-alkyl, and —CH2NHC(O)-alkyl;
R8 is selected from the group consisting of hydrogen, alkyl, arylalkylenyl, alkoxyalkylenyl, aryloxyalkylenyl, benzyloxyalkylenyl, aryl-(CH2)2-6—O-alkylenyl, and cycloalkylalkylenyl; wherein any of the alkyl, arylalkylenyl, alkoxyalkylenyl, aryloxyalkylenyl, benzyloxyalkylenyl, aryl-(CH2)2-6—O-alkylenyl, and cycloalkylalkylenyl groups can be either unsubstituted or substituted with one or more substituents selected from the group consisting of halogen, hydroxyl, alkyl, alkoxy, haloalkyl, and nitrile;
R7 is selected from the group consisting of hydrogen, alkyl, arylalkylenyl, alkoxyalkylenyl, aryloxyalkylenyl, benzyloxyalkylenyl, aryl-(CH2)2-6—O-alkylenyl, and cycloalkylalkylenyl; wherein any of the alkyl, arylalkylenyl, alkoxyalkylenyl, aryloxyalkylenyl, benzyloxyalkylenyl, aryl-(CH2)2-6—O-alkylenyl, and cycloalkylalkylenyl groups can be either unsubstituted or substituted with one or more substituents selected from the group consisting of halogen, hydroxyl, alkyl, alkoxy, haloalkyl, and nitrile;
R5 and R6 are independently selected from the group consisting of hydrogen, —C(O)—O— alkyl, alkyl, cycloalkyl, aryl, arylalkylenyl, aryloxyalkylenyl, heteroaryl, heteroarylalkylenyl, heteroaryloxyalkylenyl, cycloalkylalkylenyl, aryl-(CH2)2-6—O-alkylenyl, and benzyloxyalkylenyl; wherein any of the alkyl, cycloalkyl, aryl, arylalkylenyl, aryloxyalkylenyl, heteroaryl, heteroarylalkylenyl, heteroaryloxyalkylenyl, cycloalkylalkylenyl, aryl-(CH2)2-6—O-alkylenyl, and benzyloxyalkylenyl groups can be either unsubstituted or substituted with one or more substituents independently selected from the group consisting of halogen, hydroxyl, alkoxy, alkyl, haloalkyl, cycloalkyl, nitrile, aryl, heteroaryl, and dialkylamino; or a pharmaceutically acceptable salt thereof.

US Pat. No. 10,766,895

PREPARATION METHODS FOR PALBOCICLIB FREE BASE CRYSTAL FORM A AND CRYSTAL FORM B

ZHEJIANG HUAHAI PHARMACEU...

1. A method for preparing crystal form B of palbociclib of the Formula I: the method comprising:
treating a pharmaceutically acceptable salt of palbociclib with a base selected from the group consisting of ammonia, sodium hydroxide, potassium hydroxide, sodium carbonate and potassium carbonate in an aqueous solvent selected from the group consisting of water and a co-solvent mixture consisting of water and a water-miscible organic solvent selected from the group consisting of methanol, ethanol, isopropanol and tetrahydrofuran, at a temperature in the range of 0° C. to 20° C., to obtain crystal form B of palbociclib;
wherein crystal form B of palbociclib exhibits an X-ray powder diffraction pattern comprising characteristic peaks having 2? angles selected from the group consisting of 6.094°, 6.692°, 11.049°, 12.154°, 12.940°, 16.498°, 19.879°, 22.684°, and 26.778°.

US Pat. No. 10,766,894

AZA-INDAZOLE COMPOUNDS FOR USE IN TENDON AND/OR LIGAMENT INJURIES

NOVARTIS AG, Basel (CH)

1. A compound of formula (I) or a pharmaceutically acceptable salt thereofwherein,R1 is selected from C1-C3alkyl and halogen;
R2 is selected from NHSO2(CH2)nR3 and SO2NR5R6;
n is 0 or 1;
R3 is selected from phenyl optionally substituted once or more than once with R4; C3-C6cycloalkyl optionally substituted with hydroxyl; and a fused bicyclic aromatic ring system;
R4 is independently selected from halogen, C1-C3alkoxy, cyano, C1-C3alkyl, hydroxyl, haloC1-C3alkyl, NHC(O)CH3, haloC1-C3alkoxy, and SO2NH(CH3); or
two R4 at adjacent carbon atoms form a 5- or 6-membered heterocyclic non-aromatic ring comprising at least one heteroatom selected from N, O, or S said heterocyclic ring being fused to the phenyl ring and being optionally substituted with C(O)CH3;
R5 is selected from H and C1-C3alkyl;
R6 is selected from a C3-C6cycloalkyl optionally substituted once or more than once with R7; phenyl optionally substituted once or more than once with halogen; C1-C6alkyl optionally substituted with hydroxyl; 4- to 6-membered heterocyclic non-aromatic ring comprising at least one heteroatom selected from N, O or S optionally substituted once or more than once with oxo; and benzyl;
R7 is independently selected from hydroxyl, haloC1-C3alkyl, halogen, C1-C3alkyl, C(O)OH, and hydroxyC1-C3alkyl;
or
R5 and R6 together with the N atom to which they are attached form a 4-, 5- or 6-membered heterocyclic non-aromatic ring optionally comprising one additional heteroatom selected from N, O or S, said ring being optionally substituted once or more than once with R8; a 6- to 8-membered saturated bicyclic ring system;
R8 is independently selected from halogen; hydroxyC1-C3alkyl; C(O)NH2; hydroxyl; haloC1-C3alkyl optionally substituted with hydroxyl; phenoxy; and SO2C1-C3alkyl.

US Pat. No. 10,766,892

GLS1 INHIBITORS FOR TREATING DISEASE

Board of Regents, The Uni...

1. A compound of structural Formula II:
or a salt thereof, wherein:
n is chosen from 3, 4, and 5;
each RX and RY is independently chosen from alkyl, cyano, H, and halo, or two RX groups together with the atoms to which they are attached optionally form a cycloalkyl ring;
A1 and Z1 are independently chosen from C and N;
A2, A3, A4, Z2, Z3, and Z4 are independently chosen from N, O, S, and CH, wherein at least one of A1, A2, A3, and A4 and at least one of Z1, Z2, Z3, and Z4 is chosen from N, 0, and S;
R1 and R2 are each independently chosen from alkenyl, alkyl, aryl, arylalkyl, cycloalkyl, cycloalkylalkyl, H, halo, haloalkyl, heteroaryl, heteroarylalkyl, heterocycloalkyl, and heterocycloalkylalkyl, wherein R1 and R2 each may be optionally substituted with one to three RZ groups, wherein R1 and R2 together with the atoms to which they are attached optionally form an heteroaryl, or heterocycloalkyl ring, which may be optionally substituted with one to three RZ groups;
R3 is chosen from alkenyl, alkoxy, alkyl, aryl, arylalkyl, cyano, cycloalkyl, cycloalkylalkyl, H, halo, haloalkyl, heteroaryl, heteroarylalkyl, heterocycloalkyl, heterocycloalkylalkyl, hydroxyl, C(R4)2C(O)R4, C(R4)2C(O)N(R4)2, C(R4)2N(R4)2, C(R4)2NR4C(O)R4, C(R4)2NR4C(O)OR4, C(R4)2NR4C(O)N(R4)2, C(R4)2NR4S(O)R4, C(R4)2NR4S(O)2R4, NR4C(O)R4, NR4C(O)OR4, NR4C(O)N(R4)2, NR4S(O)R4, NR4S(O)2R4, C(O)N(R4)2, S(O)N(R4)2, S(O)2N(R4)2, C(O)R4, SR4, S(O)R4, and S(O)2R4;
wherein each R3 may be optionally substituted with one to three RZ groups;
each R4 is independently chosen from aryl, arylalkyl, cycloalkyl, cycloalkylalkyl, H, heteroaryl, heteroarylalkyl, heterocycloalkyl, and heterocycloalkylalkyl wherein each R4 may be optionally substituted with one to three RZ groups, wherein two R4 groups together with the atoms to which they are attached optionally form an heteroaryl, or heterocycloalkyl ring, which may be optionally substituted with one to three RZ groups;
each RZ group is independently chosen from alkenyl, alkoxy, alkoxyalkyl, alkoxyaryl, alkoxyarylalkyl, alkoxycycloalkyl, alkoxycycloalkylalkyl, alkoxyhaloalkyl, alkoxyheteroaryl, alkoxyheteroarylalkyl, alkoxyheterocycloalkyl, alkoxyheterocycloalkylalkyl, alkyl, alkylaryl, alkylarylalkyl, alkylcycloalkyl, alkylcycloalkylalkyl, alkylheteroaryl, alkylheteroarylalkyl, alkylheterocycloalkyl, alkylheterocycloalkylalkyl, aryl, arylalkyl, arylalkyloxy, arylhaloalkyl, aryloxy, cyano, cycloalkyl, cycloalkylalkyl, cycloalkylalkyloxy, cycloalkylhaloalkyl, cycloalkyloxy, H, halo, haloalkoxy, haloalkoxyalkyl, haloalkoxyaryl, haloalkoxyarylalkyl, haloalkoxycycloalkyl, haloalkoxycycloalkylalkyl, haloalkoxyheteroaryl, haloalkoxyheteroarylalkyl, haloalkoxyheterocycloalkyl, haloalkoxyheterocycloalkylalkyl, haloalkyl, haloalkylaryl, haloalkylarylalkyl, haloalkylcycloalkyl, haloalkylcycloalkylalkyl, haloalkylheteroaryl, haloalkylheteroarylalkyl, haloalkylheterocycloalkyl, haloalkylheterocycloalkylalkyl, haloaryl, haloarylalkyl, haloarylalkyloxy, haloaryloxy, halocycloalkyl, halocycloalkylalkyl, halocycloalkylalkyloxy, halocycloalkyloxy, haloheteroaryl, haloheteroarylalkyl, haloheteroarylalkyloxy, haloheteroaryloxy, haloheterocycloalkyl, haloheterocycloalkylalkyl, haloheterocycloalkylalkyloxy, haloheterocycloalkyloxy, heteroaryl, heteroarylalkyl, heteroarylalkyloxy, heteroarylhaloalkyl, heteroaryloxy, heterocycloalkyl, heterocycloalkylalkyl, heterocycloalkylalkyloxy, heterocycloalkylhaloalkyl, heterocycloalkyloxy, hydroxyl, oxo, N(R5)2, NR5C(O)R5, NR5C(O)OR5, NR5C(O)N(R5)2, NR5S(O)R5, NR5S(O)2R5, C(O)N(R5)2, S(O)N(R5)2, S(O)2N(R5)2,C(O)R5,C(O)OR5, SR5, S(O)R5, and S(O)2R5;
each R5 is independently chosen from alkenyl, alkoxy, alkyl, aryl, arylalkyl, cyano, cycloalkyl, cycloalkylalkyl, H, haloalkyl, heteroaryl, heteroarylalkyl, heterocycloalkyl, and heterocycloalkylalkyl, wherein two R5 groups together with the atoms to which they are attached optionally form an aryl, cycloalkyl, heteroaryl, or heterocycloalkyl ring, which may be optionally substituted with one to three RX groups.

US Pat. No. 10,766,891

METHYLAMINE DERIVATIVES AS LYSYSL OXIDASE INHIBITORS FOR THE TREATMENT OF CANCER

1. A compound of Formula (I):
wherein:
X is selected from the group consisting of: S, NRN and O; wherein RN is selected from the group consisting of: H, C1-4 alkyl, C1-4 haloalkyl and C3-6 cycloalkyl, wherein the C1-4 alkyl, C1-4 haloalkyl and C3-6 cycloalkyl groups are themselves optionally substituted with a substituent selected from the group consisting of: RA1, halo, —ORA1, ?O, —NRA1RB1, —SRA1, —CN, —NO2, —NRA1C(O)RB1, —C(O)NRA1RB1, —NRA1C(O)ORB1, —OC(O)NRA1RB1, —NRA1C(O)NRA1RB1, —NRA1SO2RB1, —SO2NRA1RB1, —SO2RA1, —C(O)RA, —C(O)ORA1 and C3-6 cycloalkyl;
Y is selected from the group consisting of: N and CR; wherein R is selected from the group consisting of: H, halo, C1-4 alkyl, CI-4 haloalkyl, —ORA1, —NRA1RB1, —SRA1, —CN, —NO2, —NRA1C(O)RB1, —C(O)NRA1RB1, —NRA1C(O)ORB1, —OC(O)NRA1RB1, —NRA1C(O)NRA1RB1, —NRA1SO2RB1, —SO2NRA1RB1, —SO2RA, —C(O)RA1, —C(O)ORA1 and C3-6 cycloalkyl, wherein the C1-4 alkyl, C1-4 haloalkyl and C3-6 cycloalkyl groups are themselves optionally substituted with a substituent selected from the group consisting of: RA1, halo, —ORA, ?O, —NRA1RB1, —SRA1, CN, —NO2, —NRA1C(O)RB1, —C(O)NRA1RB1, —NRA1C(O)ORB1, —OC(O)NRA1RB1, —NRA1C(O)NRA1RB1, —NRA1SO2RB1, —SO2NRA1RB1, —SO2RA, —C(O)RA1, —C(O)ORA1 and C3-6 cycloalkyl;
one of W and Z is carbon and is bonded to the

 residue and the other of W and Z is selected from the group consisting of: N and CR; wherein R is selected from the group consisting of: H, halo, —ORA1, —NRA1RB1, —SRA1, —CN, —NO2, —NRA1C(O)RB1, —C(O)NRA1RB1, —NRA1C(O)ORB1, —OC(O)NRA1RB1, —NRA1C(O)NRA1RB1, —NRA1SO2RB1, —SO2NRA1RB1, —SO2RA1, —C(O)RA1, —C(O)ORA1 and C3-6 cycloalkyl, wherein the C3-6 cycloalkyl groups are themselves optionally substituted with a substituent selected from the group consisting of: RA1, halo, —ORA1, ?O, —NRA1RB, —SRA1, CN, —NO2, —NRA1C(O)RB1, —C(O)NRA1RB1, —NRA1C(O)ORB1, —OC(O)NRA1RB1, —NRA1C(O)NRA1RB1, —NRA1SO2RB1, —SO2NRA1RB1, —SO2RA1, —C(O)RA1, —C(O)ORA1 and C3-6 cycloalkyl;
x is 1 or 2;
n is 0, 1,2, 3,4, 5 or 6;
R1 and R2 are independently selected at each occurrence from: H, halo, C1-4 alkyl, C1-4 haloalkyl, —ORA1, —NRA1RB1, —CN, —NO2, —NRA1C(O)RB1, —C(O)NRA1RB1, —NRA1SO2RB1, —SO2NRA1RB1, —SO2RA1, —C(O)RA1, —C(O)ORA1 and C3-6 cycloalkyl, or together R1 and R2 are ?O, wherein the C1-4 alkyl, C1-4 haloalkyl and C3-6 cycloalkyl groups are themselves optionally substituted with RA1, halo, —ORA1, ?O, —NRA1RB1, —SRA1, —CN, —NO2, —NRA1C(O)RB1, —C(O)NRA1RB1, —NRA1C(O)ORB1, —OC(O)NRA1RB1, —NRA1C(O)NRA1RB1, —NRA1SO2RB1, —SO2NRA1RB1, —SO2RA1, —C(O)RA1, —C(O)ORA1 and C3-6 cycloalkyl;
when n is 0, R3 is optionally substituted 3- to 15-membered ring system, including 0, 1, 2 or 3 heteroatoms selected from N, O or S, wherein the ring system is connected to the remainder of the compound of Formula (I) via a carbon atom, and when n is 1, 2, 3, 4, 5 or 6 R3 is selected from the group consisting of optionally substituted 3- to 15-membered ring system, including 0, 1, 2 or 3 heteroatoms selected from N, O or S, halo, —ORA1, —NRA1RB1, —SRA1, —CN, —NO2, —NRA1C(O)RB1, —C(O)NRA1RB1, —NRA1C(O)ORB1, —OC(O)NRA1RB1, —NRA1C(O)NRA1RB1, —NRA1SO2RB1, —SO2NRA1RB1, —SO2RA1, —C(O)RA and —C(O)ORA1; and
RA1 and RB1 are at each occurrence independently selected from the group consisting of: H, C1-4 alkyl, C1-4 haloalkyl and C1-4 alkyl substituted with a substituent selected from the group consisting of: —ORA5, —NRA5RB5, —CN, —NO2, —N3, —NRA5C(O)RB5, —C(O)NRA5RB5, —NRA5SO2RB5, —SO2NRA5RB5, —SO2RA5, —C(O)RA5, —C(O)ORA5 and C3-6 cycloalkyl, wherein RA5 and RB5 are each independently selected from the group consisting of H and C1-4 alkyl; wherein in the specific group —NRA1RB1, RA1 and RBI, together with the nitrogen atom to which they are bonded can form a 4- to 7-membered ring system; and wherein in the specific group —NRA5RB5, RA5 and RB5, together with the nitrogen atom to which they are bonded can form a 4- to 7-membered ring system;
with the proviso that the following compounds are excluded:

or a pharmaceutically acceptable salt thereof.

US Pat. No. 10,766,890

HEPATITIS B CORE PROTEIN MODULATORS

Assembly Biosciences, Inc...

1. A compound represented by:
wherein
Y is S(O)y, wherein y is 2;
Rz is H;
Rm? and Rm are each H;
R21 is selected for each occurrence from the group consisting of H, and C1-6alkyl;
q is 0, 1, or 2;
R22 is selected from the group consisting of hydroxyl, nitro, cyano, carboxy, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, NR?R?, —C(O)—C1-6alkyl, —C(O)—C1-6alkoxy, —C(O)—NR?R?, —C(?NH)—NR?R?, X2-phenyl (optionally substituted by one, two or three substituents represented by R63), phenyl (optionally substituted by one, two or three substituents represented by R63), 5-6 membered monocyclic heteroaryl (optionally substituted by one, two or three substituents represented by R63), 9-10 membered bicyclic heteroaryl (optionally substituted by one, two or three substituents represented by R73), C3-6cycloalkyl, —S(O)w-C1-6alkyl (where w is 0, 1 or 2), —S(O)w—NR?R? (where w is 0, 1 or 2), and —NR?—S(O)w, (where w is 0, 1 or 2);
R? is selected, independently for each occurrence, from H, methyl, ethyl, and propyl;
R? is selected, independently for each occurrence, from H, methyl, ethyl, propyl, butyl, —C(O)-methyl and —C(O)-ethyl, or R? and R? taken together with the nitrogen to which they are attached may form a 4-7 membered heterocycle;
each of moieties R4, R5, R6, R7, R8, R9, and R10 is independently selected for each occurrence from the group consisting of hydrogen, C1-6alkyl, C2-6alkynyl, C2-6alkenyl, halogen, hydroxyl, nitro, cyano, and NR?R?;
R63 is selected independently at each occurrence from the group consisting of H, halogen, hydroxyl, nitro, cyano, carboxy, C1-6alkyl, —C(O)—O—C1-6alkyl, heterocycle (optionally substituted by halogen or NR?R?), —C(O)—NR?R?, —C(?NH)—NR?R?, heteroaryl, phenyl, benzyl, C2-6alkenyl, C2-6alkynyl, C1-6alkoxy, carboxy, NR?R?, —C(O)—C1-6alkyl, —C(O)—C1-6alkoxy, C3-6cycloalkyl, —S(O)w—C1-6alkyl (where w is 0, 1 or 2), —S(O)w—NR?R? (where w is 0, 1 or 2), —NR?—S(O)w—C1-6alkyl (where w is 0, 1 or 2), X2—R69;
R69 is selected from the group consisting of H, halogen, hydroxyl, nitro, cyano, C1-6alkyl, —C(O)—O—C1-6alkyl, heterocycle (optionally substituted by halogen or NR?R?),), —C(O)—NR?R?, —C(?NH)—NR?R?, heteroaryl, phenyl, C2-6alkenyl, C2-6alkynyl, C1-6alkoxy, carboxy, NR?R?, —C(O)—C1-6alkyl, —C(O)—C1-6alkoxy, C3-6cycloalkyl, —S(O)w—C1-6alkyl (where w is 0, 1 or 2), —S(O)w—NR?R? (where w is 0, 1 or 2), and —NR?—S(O)w— C1-6alkyl (where w is 0, 1 or 2),
X2 is selected from S(O)w (wherein w is 0, 1, or 2), O, CH2, or NR?;
wherein for each occurrence, C1-6alkyl may be optionally substituted with one, two, three or more substituents selected from the group consisting of halogen, hydroxyl, nitro, cyano, carboxy, C2-6alkenyl, C2-6alkynyl, NR?R?, —NR?—S(O)w—C1-6alkyl (where w is 0, 1 or 2), and S(O)w—NR?R?(where w is 0, 1 or 2); C1-6alkoxy may be optionally substituted with one, two, three or more substituents selected from the group consisting of halogen, hydroxyl, nitro, cyano, carboxy, C1-6alkyl, NR?R?, —NR?—S(O)w— C1-6alkyl (where w is 0,1 or 2), and S(0)w—NR?R? (where w is 0, 1 or 2);
and pharmaceutically acceptable salts thereof.

US Pat. No. 10,766,889

ARYL-2,2?-TANDEM BISTHIAZOLE COMPOUND AND PREPARATION METHOD AND USE THEREOF

Shanghai Institute of Mat...

1. A compound of formula I or an optical isomer thereof, or a pharmaceutically acceptable salt thereof:
wherein,
R1 is selected from the group consisting of H, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C6 cycloalkyl, and C5-C10 aryl; and R2 is selected from the group consisting of C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C6 cycloalkyl, and C5-C10 aryl; or
R1 is selected from the group consisting of C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C6 cycloalkyl, and C5-C10 aryl; and R2 is selected from the group consisting of H, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C6 cycloalkyl, and C5-C10 aryl;
or R1 and R2 together with the carbon atom to which they are attached form a 5-7 membered saturated or partially saturated ring;
R3 is selected from the group consisting of H, C1-C6 alkyl, C3-C6 cycloalkyl, C2-C6 alkenyl, C2-C6 alkynyl, and C5-C10 aryl; and
R4 is selected from the group consisting of C1-C6 alkyl, C3-C6 cycloalkyl, C2-C6 alkenyl and C2-C6 alkynyl;
wherein the C1-C6 alkyl, C3-C6 cycloalkyl, C2-C6 alkenyl, C2-C6 alkynyl, or C5-C10 aryl is unsubstituted or substituted with one or more groups selected from the group consisting of halogen, C1-C6 alkyl, halogenated C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 alkoxy, halogenated C1-C6 alkoxy, C3-C6 cycloalkyl, and C5-C10 aryl.

US Pat. No. 10,766,885

SILIBININ 3,3?-THIODIPROPIONIC ACID ESTER WITH HEPATOPROTECTIVE ACTIVITY AND A METHOD OF PREPARING THE SAME

1. A compound having the following formula (I):

US Pat. No. 10,766,884

CYCLIN DEPENDENT KINASE INHIBITORS

Pfizer Inc., New York, N...

4. A pharmaceutical composition comprising the compound of claim 1, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier or excipient.

US Pat. No. 10,766,882

1,2-NAPHTHOQUINONE BASED DERIVATIVE AND METHOD OF PREPARING THE SAME

YUNGJIN PHARM CO., LTD., ...

1. A method of preparing 2-isopropyl-1H-naphtho[2,1-d]imidazole-4,5-dione comprising the following steps:1) synthesizing compound B-1 by reacting compound A and isobutyric anhydride under basic conditions formed using pyridine;
2) reacting compound B-1 and HNO3 under acidic conditions formed using acetic acid anhydride;
3) reducing compound B-2 using Pd/C and hydrazine;
4) cyclizing compound B-3 under acidic conditions formed using acetic acid; and
5) oxidation of compound B-4 using 2-iodoxybenzoic acid (IBX) under basic conditions formed using DMF to generate 2-isopropyl-1H-naphtho[2,1-d]imidazole-4,5-dione (compound B-5):

US Pat. No. 10,766,881

2-ARYL- AND 2-HETEROARYL-SUBSTITUTED 2-PYRIDAZIN-3(2H)-ONE COMPOUNDS AS INHIBITORS OF FGFR TYROSINE KINASES

Array Biopharma Inc., Bo...

1. A method for treating cancer in a patient in need thereof, the method comprising administering to the patient a therapeutically effective amount of a compound of general Formula I:and pharmaceutically acceptable salts thereof, wherein:X is N or CH;
Ring A is a 5-membered heteroaryl ring having 1-2 ring nitrogen atoms;
z is 1, 2 or 3;
each R1 is independently selected from the group consisting of:
(a) hydrogen;
(b) C1-C6 alkyl optionally substituted with 1-3 fluoros,
(c) hydroxy(C1-C6 alkyl)- optionally substituted with 1-3 fluoros,
(d) dihydroxy(C1-C6 alkyl)- optionally substituted with 1-3 fluoros,
(e) cyano(C1-C6 alkyl)-,
(f) RaRbN(C1-C6 alkyl)-,
(g) (C1-C3 alkoxy)C1-C6 alkyl- optionally substituted with 1-3 fluoros,
(h) (C3-C6 cycloalkyl)(CH2)n— where n is 0-3 and said cycloalkyl is optionally substituted with CN, OH, RaRbN—, (1-3C)alkyl, or (1-3C)alkoxy;
(i) hetCyc1(CH2)m— where m is 0-3,
(j) hetCyc2(CH2)p— where p is 0 or 1,
(k) hetAr1(CH2)q— where q is 1 or 2,
(l) halogen, and
(m) hetCyc1C(?O)CH2—;
hetCyc1 is a 4-7 membered saturated heterocyclic ring having 1-2 ring heteroatoms independently selected from N and 0, wherein said heterocyclic ring is optionally substituted with one or more substituents independently selected from the group consisting of fluoro, HO, C1-C6 alkyl (optionally substituted with 1-3 fluoros), (C1-C6 alkoxy)C1-C6 alkyl- (optionally substituted with 1-3 fluoros), (C3-C6 cycloalkoxy)C1-C6 alkyl-, hydroxy(C1-C6 alkyl)-, RcRdN— and (C1-C6 alkyl)C(?O)-;
hetCyc2 is a 7-10 membered heterospirocyclic ring having 1-2 ring heteroatoms independently selected from N and 0, wherein said heterospirocyclic ring is optionally substituted with one or more substituents independently selected from the group consisting of C1-C6 alkyl (optionally substituted with 1-3 fluoros), (C1-C6 alkoxy)C1-C6 alkyl- (optionally substituted with 1-3 fluoros), (C3-C6 cycloalkoxy)C1-C6 alkyl-, hydroxy(C1-C6 alkyl)-, RcRdN— and (C1-C6 alkyl) C(?O)-;
hetAr1 is a 6-membered heteroaryl ring having 1-2 ring nitrogen atoms, wherein said ring is optionally substituted with one or more substituents independently selected from C1-C6 alkyl and halogen;
R2 is Ar1 or hetAr2;
Ar1 is phenyl substituted with one or more groups independently selected from halogen, cyano, C1-C3 alkyl, C1-C3 alkoxy, (C1-C3 alkyl)NHC(?O)—, (C1-C3 alkyl)C(?O)NH—, (cyclopropyl)C(?O)NH— and (cyclopropyl)NHC(?O)—, wherein each of said C1-C3 alkyl and C1-C3 alkoxy portions is optionally substituted with 1-3 fluoros;
hetAr2 is a 6-10 membered heteroaryl ring having 1-2 ring nitrogen atoms, wherein said ring is optionally substituted with one or more groups independently selected from halogen, C1-C3 alkyl, C1-C3 alkoxy, (C1-C3 alkyl)NHC(?O)—, (C1-C3 alkyl)C(?O)NH—, (C3-C4 cycloalkyl)C(?O)NH- and (C3-C4 cycloalkyl)NHC(?O)—, wherein each of said C1-C3 alkyl and C1-C3 alkoxy portions is optionally substituted with 1-3 fluoros;
R3 is H, C1-C4 alkyl or (C3-C4)cycloalkyl; and
Ra, Rb, Rc and Rd are independently hydrogen or C1-C6 alkyl optionally substituted with F, OH or C1-C6 alkoxy.

US Pat. No. 10,766,880

SUBSTITUTED 1,2,3-TRIAZOLES AS NR2B-SELECTIVE NMDA MODULATORS

JANSSEN PHARMACEUTICA NV,...

1. A compound, and pharmaceutically acceptable salts thereof, having the structure of Formula (I):
wherein:
Ar1 is selected from the group consisting of:
(a) phenyl substituted with one substituent selected from the group consisting of: F, Br, I, C1-6alkyl, C1-6perhaloalkyl, and OC1-6perhaloalkyl; phenyl substituted with two or three substituents each independently selected from the group consisting of: halo, C1-6alkyl, C1-6perhaloalkyl, OC1-6alkyl, OC1-6perhaloalkyl, C3-6cycloalkyl, and azetidinyl;
(b) pyridinyl; pyridinyl substituted with one or two members each independently selected from the group consisting of: halo, CH3, CF3, and CF2H; and
(c) thienyl substituted with CF3; 1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl; or 2,3-dihydro-1H-inden-5-yl;
R1 is H, halo, or CH3;
R2 is H or CH3; and
Ar3 is selected from the group consisting of:
(a) pyridinyl; pyridinyl substituted with one or two substituents each independently selected from the group consisting of: Cl, F, CH3, OCH3, CF3, C(CH3)2OH; azetidin-1-yl; 3-fluoroazetidin-1-yl; and 3,3-difluoroazetidin-1-yl;
(b) pyridazinyl; pyridazinyl substituted with one or two substituents each independently selected from the group consisting of: CH3, OCH3, and CF3;
(c) pyrimidin-4-yl; pyrimidin-4-yl substituted with one or two substituents each independently selected from the group consisting of: Cl, CH3, CF3, and OCH3; pyrimidin-2-yl; pyrimidin-2-yl substituted one or two members each independently selected from the group consisting of: halo, C1-6alkyl, C1-6alkyl substituted with OH or OCH3, C(OH)(CH3)(CF3), CH2OCHF2, CH2OCF3, CH2OCH2CH3, CH(NH2)CH3, CH2NH(CH3), C1-6perhaloalkyl, OC1-6alkyl, OC1-6perhaloalkyl, C(?N-OH)(CH3), NH2, NH(CH3), N(CH3)2, NH(CH2CH3), NH(CH2CHF2), NH(cyclopropyl), NH(difluorocyclobutyl), NH-oxetanyl, CN, C(?O)CH3, C(?O)NH(CH3), C(?O)N(CH3)2, SO2CH3, CO2CH3, C(CH3)(?N-OH), cyclopropyl, azetidin-1-yl, 3-fluoroazetidin-1-yl, 3,3-difluoroazetidin-1-yl, 3-(difluoromethyl)azetidin-1-yl, 3-methoxyazetidin-1-yl, 3-fluoro-3-methyl-azetidin-1-yl, pyrrolidin-1-yl, 3-fluoropyrrolidin-1-yl, 3,3-difluoropyrrolidin-1-yl, piperidin-1-yl, morpholinyl, 1H-pyrrol-2-yl, 2-furyl, 1H-pyrazol-4-yl, 1H-pyrazol-5-yl, 1H-pyrazol-1-yl, 2-methyl-1H-imidazol-1-yl, 1-methylpyrazol-3-yl, and phenyl;
(d) 5-fluoro-pyrazin-2-yl; 5-methylpyrazin-2-yl; 6-methylpyrazin-2-yl; pyrazin-2-yl; (2-thienyl)pyrazin-2-yl, and 2,3-dimethyl pyrazin-5-yl; and
(e) 5-methyl-1H-imidazol-2-yl; 5-methylthiazol-2-yl.

US Pat. No. 10,766,879

PYRIMIDINE DERIVATIVES AS KINASE INHIBITORS AND THEIR THERAPEUTICAL APPLICATIONS

NANTBIOSCIENCE, INC., Cu...

1. A compound of the formula
or a pharmaceutically acceptable salt thereof, wherein:
W is selected from the group consisting of: Cl, Br, I, CN, and CONH2;
Ar represents heteroaryl or aryl, each of which is substituted with from 0 to 4 substituents independently chosen from the group consisting of:
(1) halogen, hydroxy, amino, amide, cyano, —COOH, —SO2NH2, oxo, nitro or alkoxycarbonyl;
(2) NR1; and
(3) groups of the formula

wherein:
R1 represents hydrogen, alkyl, cycloalkyl, alkenyl, alkynyl, alkylthio, aryl, or arylalkyl;
R4 represents hydrogen, C1-C4 alkyl, or oxo;
X—R3 is CH; or X—R3 is O; or X is N, and R3 represents hydrogen, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C10 aryl or heteroaryl, (C3-C7 cycloalkyl)C1-C4 alkyl, C1-C6 haloalkyl, C1-C6 alkoxy, C1-C6 alkylthio, C2-C6 alkanoyl, C1-C6 alkoxycarbonyl, C2-C6 alkanoyloxy, mono- and di-(C3-C8 cycloalkyl)aminoC0-C4alkyl, (4- to 7-membered heterocycle)C0-C4alkyl, C1-C6 alkylsulfonyl, mono- and di-(C1-C6 alkyl) sulfonamido, and mono- and di-(C1-C6 alkyl)aminocarbonyl, each of which is substituted with from 0 to 4 substituents independently chosen from halogen, hydroxy, cyano, amino, —COOH or oxo;
R5 and R6 are independently selected from the group consisting of: hydrogen, F, Cl, and Br; and
R7, R8 and R9 are independently selected from the group consisting of: hydrogen and CH3.

US Pat. No. 10,766,878

SULFONYLCYCLOALKYL CARBOXAMIDE COMPOUNDS

Genentech, Inc., South S...

1. A compound of formula (I) or a pharmaceutically acceptable salt thereof:
wherein:
n is 2 or 3;
R1 is aryl or heteoraryl, each optionally substituted with one or more groups independently selected from halogen, —CN, —C1-6 alkyl and —C1-6 haloalkyl;
m is 0, 1, 2, or 3;
each R2 is independently selected from halogen, —C1-6 alkyl, —C1-6 haloalkyl, —O—C1-6 alkyl, —C3-7 cycloalkyl, and —CN;
R3 is an amide selected from the orientation —NH—C(O)— and —C(O)—NH—;
R4 is a 4, 5, 6 or 7-membered heterocycle, aryl or heteroaryl optionally substituted with one or more groups independently selected from halogen, —C1-6 alkyl, —C1-6 haloalkyl, —O—C1-6 haloalkyl, and —CN;
A is selected from A1, A2 and A3 wherein:
A1 is unsubstituted or substituted 5-membered heteroaryl comprising one or two nitrogen hetero atoms;
A2 is unsubstituted or substituted aryl; and
A3 is unsubstituted or substituted 6-membered heteroaryl comprising one or two hetero nitrogen atoms; and
each * independently denotes a chiral center (i) in an R configuration or in an S configuration or (ii) a mixture of R and S configurations for a plurality of compounds of formula (I).

US Pat. No. 10,766,872

COMPOUNDS FOR THE TREATMENT OF MYCOBACTERIAL INFECTIONS

The Board Institute, Inc....

1. A compound of Formula I or a pharmaceutically acceptable salt thereof:wherein:R1 is selected from the group consisting of phenyl, substituted phenyl, pyridinyl, and substituted pyridinyl;
R3 is hydrogen, substituted C1-C8 alkyl, or unsubstituted C1-C8 alkyl;
R4 is hydrogen, substituted C1-C8 alkyl, or unsubstituted C1-C8 alkyl;
R2 is

R6 and R7 are each independently selected from the group consisting of hydrogen and unsubstituted C1-C8 alkyl;
R5 is selected from the group consisting of

R100 and R100? are each independently hydrogen or unsubstituted C1-C8 alkyl;
R101 and R102 are each independently hydrogen or unsubstituted C1-C8 alkyl;
wherein the term “substituted” refers to the replacement of one or more hydrogen radicals in a given structure with the radical selected from halo, alkyl, alkenyl, alkynyl, aryl, heterocyclyl, thiol, alkylthio, arylthio, alkylthioalkyl, arylthioalkyl, alkylsulfonyl, alkylsulfonylalkyl, arylsulfonylalkyl, alkoxy, aryloxy, aralkoxy, aminocarbonyl, alkylaminocarbonyl, arylaminocarbonyl, alkoxycarbonyl, aryloxycarbonyl, haloalkyl, amino, cyano, nitro, alkylamino, arylamino, alkylaminoalkyl, arylaminoalkyl, aminoalkylamino, hydroxy, alkoxyalkyl, carboxy, carboxyalkyl, alkoxycarbonylalkyl, aminocarbonylalkyl, acyl, and aralkoxycarbonyl.

US Pat. No. 10,766,871

PROCESS FOR THE EPOXIDATION OF PROPENE TO PROPYLENE OXIDE

BASF SE, Ludwigshafen am...

1. A continuous process for preparing propylene oxide, the process comprising:(i) passing a liquid feed stream, comprising propene, hydrogen peroxide, methanol, water, at least one dissolved potassium salt of hydroxyethylidene diphosphonic acid, and optionally propane, into an epoxidation reactor comprising a catalyst comprising a titanium zeolite of structure type MFI, and subjecting the liquid teed stream to epoxidation reaction conditions in the epoxidation reactor, to obtain a reaction mixture comprising propylene oxide, methanol, water, and the at least one dissolved potassium salt of hydroxyethylidene diphosphonic acid, and optionally propane; and
removing an effluent stream from the epoxidation reactor, the effluent stream comprising propylene oxide, methanol, water, at least a portion of the at least one potassium salt of hydroxyethylidenediphosphonic acid, and optionally propane.

US Pat. No. 10,766,868

METHODS FOR PREPARING SUBSTITUTED 5,6-DIHYDRO-6-PHENYLBENZO[F]ISOQUINOLIN-2-AMINE

ArQule, Inc., Burlington...

1. A method of making Compound A:or a salt thereof, comprisingStep 2: reacting Compound 2:

with Compound 3:

to form Compound 4:

US Pat. No. 10,766,867

HYDANTOINS THAT MODULATE BACE-MEDIATED APP PROCESSING

BUCK INSTITUTE FOR RESEAR...

1. A method of ameliorating one or more symptoms of a pre-Alzheimer's condition and/or cognitive dysfunction, or delaying the progression of a pre-Alzheimer's condition or cognitive dysfunction to Alzheimer's disease, said method comprising:administering to a subject in need thereof a hydantoin in an amount sufficient to ameliorate one or more symptoms of a pre-Alzheimer's cognitive dysfunction, and/or to delay the progression of a pre-Alzheimer's cognitive dysfunction to Alzheimer's disease, wherein said hydantoin is a compound having a formula selected from the group consisting of
or a pharmaceutically acceptable salt thereof.

US Pat. No. 10,766,866

DETERRENTS FOR ARTHROPODS AND MARINE ORGANISMS

University of North Texas...

1. An arthropod deterrent composition comprising:a) at least one of an effective amount of the arthropod deterrent of the compound of Formula (I) or a salt thereof;

b) at least one additional component selected from a group comprising fragrances, solvents, diluents, fixatives, carrier, paints, coatings, or combinations thereof;
wherein A1, A2, and A3 is independently selected from a group consisting of carbon, nitrogen, oxygen, and sulfur;
R1 and R2 are independently selected from a group consisting of hydrogen, deuterium, hydroxyl, C1-C6 substituted or unsubstituted alkyl, C2-C6 substituted or unsubstituted alkenyl, C1-C6 substituted or unsubstituted alkoxy; or R1 and R2 may be taken together to form a C1-C6 substituted or unsubstituted alkenyl, or ?O; and
R3, R4, R5, R6, and R7 are independently selected from a group consisting of hydrogen, deuterium, halogen, hydroxyl, C1-C6 substituted or unsubstituted alkoxy, C1-C6 substituted or unsubstituted alkyl, R1 and R3 may be taken together to form a C1-C6 substituted or unsubstituted cycloalkyl, or C2-C6 substituted or unsubstituted cycloalkenyl, R2 and R3 may be taken together to form a C1-C6 substituted or unsubstituted cycloalkyl, or C2-C6 substituted or unsubstituted cycloalkenyl, or R3 and R4 may be taken together to form a C1-C5 substituted or unsubstituted cycloalkyl, C2-C6 substituted or unsubstituted cycloalkenyl, or substituted or unsubstituted aryl.

US Pat. No. 10,766,865

PKM2 MODULATORS AND METHODS FOR THEIR USE

SUMITOMO DAINIPPON PHARMA...

1. A method for increasing PKM2 activity in the provision of decreased tumorigenicity in a subject in need thereof, the method comprising:administering an effective amount of a PKM2 activating compound in the form of a free-base or a pharmaceutically acceptable salt, or tautomer or prodrug thereof, to the subject, wherein said compound is:

US Pat. No. 10,766,864

MORPHINAN DERIVATIVES FOR THE TREATMENT OF NEUROPATHIC PAIN

Nektar Therapeutics, San...

1. A compound of Formula I:
wherein:
R1 is —N(R17)(R18);
R2, R3, R4, R5, R6, R7 R9, R19, and R11 are hydrogen;
R8 is —CH3;
R17 is a heteroaryl substituted with —X-POLY;
R18 is hydrogen;
X is a linker;
POLY is a poly(alkylene oxide); and
pharmaceutically acceptable salts thereof.

US Pat. No. 10,766,863

MONOCARBOXYLATE TRANSPORT MODULATORS AND USES THEREOF

NIROGYONE THERAPEUTICS, I...

1. A compound having the formula:or a pharmaceutically acceptable salt thereof,wherein:1) n is 0; W is a bond; X is CH2; andB is selected from:
or2) n is 1; W is a bond; X is —NCH3; andB is selected from:
R1 is selected from the group consisting of halogen, —CHF2, —CF3, —NO2, —CN, —C(O)R?, —C(O)OR?, —SO2R?, —C(O)NR?2, —C(O)N(OR?)R? andR4 is selected from the group consisting of(a) —C(O)R?, —O(CH2)0-4R?, —(CH2)0-4C(O)R?, —(CH2)0-4C(O)OR?, —NR?2, —(CH2)0-4C(O)NR?2, —(CH2)0-4S(O)R?, —(CH2)0-4S(O)2R?, or —N(OR?)R?; and
(b) a group selected from
(1)

(2) a 3-8 membered saturated or partially unsaturated cycloalkyl ring,
(3) a 3-8 membered saturated or partially unsaturated heterocycloalkyl ring having 1-2 heteroatoms independently selected from nitrogen, oxygen, and sulfur,
(4) phenyl, and
(5) a 5-6 membered heteroaryl ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, and sulfur; andR? is hydrogen or an optionally substituted group selected from:(a) C1-6 alkyl or C3-6 cycloalkyl;
(b) a 3-8 membered saturated or partially unsaturated cycloalkyl ring formed from two R?;
(c) a 3-8 membered saturated or partially unsaturated heterocycloalkyl ring formed from two R? having 1-2 heteroatoms independently selected from nitrogen, oxygen, and sulfur;
(d) phenyl; and
(e) a 5-6 membered heteroaryl ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, and sulfur,or3) n is 0; W is C(O);X is —NR5— or —CH2—, wherein R5 is hydrogen or C1-C3 alkyl;B is selected from the group consisting of phenyl; phenyl substituted with halogen, C1-C3 alkoxy, and trifluoromethyl; cyclohexyl; thiazolyl; oxazolyl; di(C1-C3 alkyl)pyrazolyl; thiophenyl; tetrahydropyranyl; pyridinyl; and N-(C1-C3 alkyl)piperidinyl;R1 is halogen, trifluoromethyl, cyano, orwherein
represents azetidinyl, pyrrolidinyl, piperidinyl or azepinyl; andR4 is selected from the group consisting of:

US Pat. No. 10,766,862

CRYSTAL FORM AND SALT FORM OF AND PREPARATION METHOD FOR TYROSINE KINASE INHIBITOR

Guangdong Raynovent Biote...

1. A crystal form of Compound 1 comprising a crystal form A, a crystal form B, a crystal form C, a crystal form D or a crystal form E,
wherein,
the crystal form A has an X-ray powder diffraction pattern with characteristic diffraction peaks at angles 2? of: 4.47±0.2°, 7.80±0.2°, 12.61±0.2°, 13.25±0.2°, 16.32±0.2°;
the crystal form B has an X-ray powder diffraction pattern with characteristic diffraction peaks at angles 2? of: 13.55±0.2°, 15.94±0.2°, 17.36±0.2°, 22.41±0.2°, 24.16±0.2°, 24.78±0.2°;
the crystal form C has an X-ray powder diffraction pattern with characteristic diffraction peaks at angles 2? of: 13.29±0.2°, 15.58±0.2°, 16.21±0.2°, 19.84±0.2°, 24.95±0.2°;
the crystal form D has an X-ray powder diffraction pattern with characteristic diffraction peaks at angles 2? of: 6.70±0.2°, 11.30±0.2°, 11.76±0.2°, 15.52±0.2°, 16.35±0.2°;
the crystal form E has an X-ray powder diffraction pattern with characteristic diffraction peaks at angles 2? of: 4.51±0.2°, 6.68±0.2°, 11.79±0.2°, 13.62±0.2°.

US Pat. No. 10,766,861

PHARMACEUTICALLY ACTIVE COMPOUNDS

BerGenBio ASA, Bergen (N...

1. A method of producing a compound of formula (I):
wherein
one of Q1 and Q2 represents a nitrogen atom and the other represents CH, or both Q1 and Q2 represent nitrogen atoms, and Q3 represents CH;
A represents an optionally substituted five- or six-membered aromatic ring;
R1 represents an aliphatic carbocyclic or heterocyclic ring, optionally substituted by —(C?O)xNRaRb, —ORc, —SO2Rg or optionally substituted alkyl, in which
x is 0 or 1;
Ra and Rb independently represent (a) H, (b) optionally substituted alkyl, (c) optionally substituted cycloalkyl, (d) optionally substituted heterocycloalkyl, (e) —(C?O)Rd, or (f) —SO2Re, wherein Rd and Re independently represent (i) optionally substituted alkyl, (ii) optionally substituted alkoxy, or (iii) optionally substituted cycloalkyl; or Ra and Rb together with the nitrogen atom to which they are attached form an optionally substituted aromatic or aliphatic heterocyclic ring;
Rc represents optionally substituted alkyl;
and
Rg represents optionally substituted cycloalkyl;
R2 represents H, optionally substituted alkyl or halo;
R3 represents an optionally substituted aryl or heteroaryl ring;
R5 and R6 independently represent H or optionally substituted alkyl; or R5 and R6 together with the carbon atom to which they are attached form an optionally substituted cycloalkyl ring, optionally containing a heteroatom;
and the corresponding N-oxides; and pharmaceutically acceptable salts and solvates of such compounds and their N-oxides;
the method comprising the steps of:
(i) reacting a compound of formula (IIc)

wherein,
Q4 represents CH or a nitrogen atom;
R4 represents H, halo or —ORf, where Rf is C1-6 alkyl; and
Rx and Ry independently represent H or a protecting group,
with a compound of formula (III)

in which R1 and R2 are as defined in connection with formula (I), and X represents OH or a halogen atom; and
(ii) removing any protecting groups.

US Pat. No. 10,766,860

LYSYL OXIDASE-LIKE 2 INHIBITORS AND USES THEREOF

PHARMAKEA, INC., San Die...

1. A compound of Formula (VI), or a pharmaceutically acceptable salt, or solvate thereof:
wherein,
each R1 is independently H, D, or F;
RA is H, D, halogen, —CN, —OR5, —N(R5)2, or substituted or unsubstituted phenyl;
L1 is absent, —O—, —S—, —S(?O)—, —S(?O)2—, or —NR2—;
R2 is H, C1-C6alkyl, C1-C6fluoroalkyl, or C1-C6deuteroalkyl;
each R3 is independently H, D, halogen, —CN, C1-C6alkyl, C1-C6fluoroalkyl, or C1-C6deuteroalkyl;
m is 0, 1, or 2;
each R4 is independently selected from C1-C6alkyl, C1-C6fluoroalkyl, C1-C6deuteroalkyl, C1-C6heteroalkyl, substituted or unsubstituted C3-C10cycloalkyl, and substituted or unsubstituted aryl;
each R5 is independently selected from H, C1-C6alkyl, C1-C6fluoroalkyl, C1-C6deuteroalkyl, C1-C6heteroalkyl, substituted or unsubstituted C3-C10cycloalkyl, substituted or unsubstituted aryl, —C1-C4alkylene-(substituted or unsubstituted C3-C8cycloalkyl), substituted or unsubstituted aryl, and —C1-C4alkylene-(substituted or unsubstituted aryl);
Ring A is phenyl;
or Ring A is bicyclic C9-C10carbocycle;
R6 is H, C1-C6alkyl, C1-C6fluoroalkyl, or C1-C6deuteroalkyl;
Q is substituted or unsubstituted C1-C6alkyl, substituted or unsubstituted C1-C6fluoroalkyl, substituted or unsubstituted C1-C6heteroalkyl, substituted or unsubstituted C3-C8cycloalkyl, —C1-C4alkylene-(substituted or unsubstituted C3-C8cycloalkyl), substituted or unsubstituted aryl, —C1-C4alkylene-(substituted or unsubstituted aryl), substituted or unsubstituted heteroaryl, or —C1-C4alkylene-(substituted or unsubstituted heteroaryl); wherein if Q is substituted then Q is substituted with one or more R8;
or Q and R6 are taken together with the N atom to which they are attached to form a ring B, wherein ring B is a substituted or unsubstituted pyrrolidinyl, wherein if ring B is substituted then ring B is substituted with 1-3 R8;
each R8 is independently D, halogen, CN, —OR5, —SR5, —S(?O)R4, —S(?O)2R4, —S(?O)2N(R5)2, NR5S(?O)2R4, C(?O)R4, OC(?O)R4, CO2R5, OCO2R4, N(R4)2, OC(?O)N(R5)2, —NHC(?O)R4, —NHC(?O)OR4, C1-C6alkyl, C1-C6fluoroalkyl, C1-C6deuteroalkyl, C1-C6heteroalkyl, substituted or unsubstituted C3-C10cycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
or two R8 groups attached to the same carbon atom are taken together with the carbon atom to which they are attached to form a substituted or unsubstituted carbocycle;
wherein any substituted group of RA, R3, R4, R5, and R8 is substituted with one or more additional groups individually and independently selected from halogen, —CN, —NH2, —NH(CH3), —N(CH3)2, —OH, —CO2H, —CO2(C1-C4alkyl), —C(?O)NH2, —C(?O)NH(C1-C4alkyl), —C(?O)N(C1-C4alkyl)2, —S(?O)2NH2, —S(?O)2NH(C1-C4alkyl), —S(?O)2N(C1-C4alkyl)2, C1-C4alkyl, C3-C6cycloalkyl, C1-C4fluoroalkyl, C1-C4heteroalkyl, C1-C4alkoxy, C1-C4fluoroalkoxy, —SC1-C4alkyl, —S(?O)C1-C4alkyl, and —S(?O)2C1-C4alkyl.

US Pat. No. 10,766,858

SUBSTITUTED BENZAMIDES AND METHODS OF USE THEREOF

GENENTECH, INC., South S...

1. A compound of formula I:
or a salt thereof wherein:
R1 is C1-8 alkyl, C2-8 alkenyl, C1-8 haloalkyl, C1-8 alkoxy, 3-20 membered carbocycle, C-linked 3-20 membered heterocycle, or —NR1AR1B, herein R1A and R1B are each independently selected from the group consisting of hydrogen, C1-8 alkyl, C1-8 alkoxy, and wherein R1A and R1B are optionally combined to form a 3-20 membered heterocycle; and wherein R1 is optionally substituted with from 1 to 5 substituents selected from the group consisting of C1-4 alkyl, C3-4 haloalkyl, F, Cl, Br, I, —OH, —CN, —NO2, —NRR1aRR1b, —ORR1a, —SRR1a, —Si(RR1a)3 and C3-6 carbocycle; wherein RR1a and RR1b are independently selected from the group consisting of hydrogen, C1-8 alkyl, and C1-8 haloalkyl;
RN is hydrogen, C1-4 alkyl or C1-4 haloalkyl;
L is a linker selected from the group consisting of C1-4 alkylene, C2-4 alkenylene and C2-4 alkynylene, wherein L is optionally substituted with from 1 to 3 substituents selected from the group consisting of ?O, C1-4 alkyl, halo, and C1-4 haloalkyl;
the subscript m is 0 or 1;
X1 and X2 are each independently selected from the group consisting of absent, —O—, —S(O)—, —S(O)2— and —N(RX)— wherein Rx is H, C1-8 alkyl, C1-8 alkanoyl, or —S(O)2(C1-8 alkyl), and wherein if the subscript m is 0 then one of X1 or X2 is absent;
the subscript n is 0, 1, 2, 3, 4, or 5;
the ring A is a 3-20 membered carbocyclyl, a 6-20 membered aryl, a 5-20 membered heteroaryl, or a 3-20 membered heterocyclyl;
each RAA is independently selected from the group consisting of C1-6 alkyl, C1-6 haloalkyl, C1-6 heteroalkyl, CN, F, Cl, Br and I; and
RA is selected from the group consisting of absent, CN, F, Cl, Br, I, RA1O—(XRB)—, (3-20 membered aryl)-(XRA)—, (3-20 membered heteroaryl)-(XRA)—, (3-20 membered carbocycle)-(XRA)—, (3-20 membered heterocycle)-(XRA)—, —RA2, and —S(O)2—RA2, wherein said 3-20 membered aryl, 3-20 membered heteroaryl, 3-20 membered carbocycle and 3-20 membered heterocycle of RA is optionally substituted with from 1 to 5 substitutents selected from, F, Cl, Br, I, —NH2, —OH, —CN, —NO2, C1-4 alkyl, C1-4 haloalkyl, C1-4 alkoxy, C1-4(halo)alkoxy, C1-4 alkylamino, C1-4 dialkylamino, C1-4 alkanoyl, C1-4 akyl-OC(?O)—, C1-4 alkyl-S(O)2—, C3-6 carbocycle, and phenyl that is optionally substituted with one or more substituents selected from fluoro, chloro, and bromo; RA1 is selected from the group consisting of hydrogen, C1-8 alkyl, C2-8 alkenyl, C1-8 haloalkyl, C3-8 cycloalkyl, phenyl and benzyl; RA2 is a C1-8 alkyl that is optionally substituted with one or more substituents selected from oxo (?O), fluoro, amino, C1-4 alkylamino and C1-4 dialkylamino; XRA is selected from the group consisting of absent, —O—, —S—, —N(H)—, —N(C1-4 alkyl)-, —S(O)—, —S(O)2—, —C(?O)—, C1-4 alkylene, C1-4 heteroalkylene, C2-4 alkenylene and C2-4 alkynylene; XRB is selected from the group consisting of absent, C1-4 alkylene, C1-4 heteroalkylene, C2-4 alkenylene and C2-4 alkynylene; wherein any C1-4 alkylene, C1-4 heteroalkylene, C2-4 alkenylene and C2-4 alkynylene of XRA or XRB is optionally substituted with 1 to 3 substituents selected from the group consisting of C1-4 alkyl, C1-4 haloalkyl, C1-4 heteroalkyl, oxo (?O), hydroxy, and phenyl that is optionally substituted with 1 to 5 substitutents selected from, F, Cl, Br, I, —NH2, —OH, —CN, —NO2, C1-4 alkyl, C1-4 haloalkyl, C1-4 alkoxy, C1-4(halo)alkoxy, C1-4 alkylamino and C1-4 dialkylamino; or wherein XRA or XRB is optionally substituted with 2 substituents that combine to form a 3-5 membered carbocycle or a 3-5 membered heterocycle;
the ring B is selected from:

D1 is N or C(RD1);
D3 is N or C(RD3);
RD1, RD2, RD3 and RD4 are each independently selected from the group consisting of H, F, Cl, Br, I, —CN, C1-8 alkyl, C1-8 haloalkyl, C1-8 alkoxy, 3-12 membered cycloalkyl, 3-12 membered heterocycle, phenyl and 5-6 membered heteroaryl comprising 1 to 3 heteroatoms selected from N, O and S, wherein said 5-6 membered heteroaryl is further optionally substituted with from 1 to 3 substituents selected from F, Cl, Br, I, —CN, C1-4 alkyl, C1-4 haloalkyl and C1-4 alkoxy;
R22 and R23 are each independently selected from the group consisting of H, F, Cl, Br, I, —CN, C1-8 alkyl, C1-8 haloalkyl and C1-8 alkoxy;
R24 is selected from the group consisting of H, F, CL, Br, I, —CN, C1-8 alkyl, C1-8 haloalkyl, C1-8 alkoxy, 3-12 membered carbocycle, 3-12 membered heterocycle, phenyl and 5-6 membered heteroaryl comprising 1 to 3 heteroatoms selected from N, O and S, wherein said 5-6 membered heteroaryl is further optionally substituted with from 1 to 3 R5 substituents selected from F, Cl, Br, I, —CN, C1-4 alkyl, C1-4 haloalkyl and C1-4 alkoxy;
R32 and R33 are each independently selected from the group consisting of H, F, Cl, Br, I, —CN, C1-8 alkyl, C1-8 haloalkyl and C1-8 alkoxy;
R34 is selected from the group consisting of H, F, Cl, Br, 1, —CN, C1-8 alkyl, C2-8 alkenyl, C1-8 haloalkyl, C1-8 alkoxy, 3-12 membered carbocycle, 3-12 membered heterocycle, phenyl and 5-6 membered heteroaryl comprising 1 to 3 heteroatoms selected from N, O and S, wherein said 5-6 membered heteroaryl is further optionally substituted with from 1 to 3 substituents selected from F, Cl, Br, I, —CN, C1-4 alkyl, C1-4 haloalkyl and C1-4 alkoxy;
R42 is selected from the group consisting of H, F, Cl, Br, I, —CN, C1-8 alkyl, C1-8 haloalkyl and C1-8 alkoxy;
R43 is selected from the group consisting of H, F, Cl, Br, I, —CN, C1-8 alkyl, C1-8 haloalkyl and C1-8 alkoxy;
R44 is selected from the group consisting of H, F, Cl, Br, I, —CN, C1-8 alkyl, C1-8 haloalkyl and C1-8 alkoxy; and
R45 is selected from the group consisting of H, C1-8 alkyl, C1-8 haloalkyl, C1-8 alkoxy, and 3-12 membered cycloalkyl, wherein said C1-8 alkoxy, and 3-12 membered cycloalkyl are optionally substituted with 1-3 substituents selected from F, Cl, Br and I.

US Pat. No. 10,766,855

HYDROXAMATE TRITERPENOID DERIVATIVES

1. A triterpene derivative of Formula (Ia) or stereoisomers, pharmaceutically acceptable salts or pharmaceutically acceptable solvates thereof,
wherein independently,
A-B is a single carbon-carbon bond or a double carbon-carbon bond;
B is a methylene (—CH2—), an olefin methine (?CH—), a hydroxymethine [—CH(OH)—], or a hydroxylated olefin carbon [—C(OH)?];
B-C is a single carbon-carbon bond or a double carbon-carbon bond; or is part of a heterocyclic ring comprising one or more heteroatoms wherein at least one of said heteroatoms is nitrogen; and wherein said heterocyclic ring is a five-membered ring comprising one nitrogen and one oxygen;
C is a hydroxymethine [—CH(OH)—], an acyloxymethine [—CH(OCOR?)—], an olefin methine (?CH—), a carbonyl [—C(?O)—], an oxime [—C(?N—OH)—] or an hydrazone [—C(?N—NH2)—], wherein R? is methyl;
D-E is a single or a double carbon-carbon bond;
F is F1a, F2a or F3a;

G is a methylene (—CH2—) or a carbonyl [—C(?O)—]; and
R is a hydroxamate group (—CONHOH);
and wherein,
when C is an acyloxymethine [—CH(OCOR?)—], the triterpene derivative of Formula (Ia) is

when B is a methylene (—CH2—), C is a hydroxymethine [—CH(OH)—], D-E is a double carbon-carbon bond, G is a methylene (—CH2—) and R is a hydroxamate (—CONHOH), F is F3a;
when B is a methylene (—CH2—), C is a hydroxymethine [—CH(OH)—], D-E is a single carbon-carbon bond, G is a methylene (—CH2—) and R is a hydroxamate (—CONHOH), F is F1a or F2a;
when B is a methylene (—CH2—), C is an oxime [—C(?N—OH)—], D-E is a double carbon-carbon bond, G is a methylene (—CH2—) and R is a hydroxamate (—CONHOH), F is F1a or F3a.

US Pat. No. 10,766,852

IONIZABLE CATIONIC LIPIDS

Translate Bio, Inc., Lex...

1. A lipid nanoparticle comprising:mRNA; and
a cationic lipid having the following structure

US Pat. No. 10,766,849

FLUORINATED DIESTER COMPOUNDS AND THEIR USE IN HEAT TRANSFER SYSTEM

MEXICHEM FLUOR S.A. DE C....

1. A composition comprising a heat transfer fluid with one or more compounds of formula (II), formula (III), or formula (IV):

US Pat. No. 10,766,845

FLUORINATION OF ACRYLATE ESTERS AND DERIVATIVES

Vifor (International) Ltd...

1. A continuous process for fluorinating a double bond to form a compound of formula 2 comprising:forming a reaction stream comprising a compound of formula 1 dissolved in 2H,3H-decafluoropentane,
wherein R1 is alkoxy;the reaction stream flowing through a continuous fluorination reactor at a flow rate of from about 0.2 mL/minute to about 2 mL/minute and fluorine gas flows through the continuous fluorination reactor at a gas flow rate of from about 0.2 mmol/minute to about 2 mmol/minute;
whereby reaction of the compound of formula 1 with the fluorine gas forms a compound of formula 2
wherein R2 is alkoxy, andfurther reacting the compound of formula 2 with an alcohol and a catalyst, wherein the reaction is a transesterification.

US Pat. No. 10,766,843

METHOD FOR PURIFYING PHENOL

LG CHEM, LTD., Seoul (KR...

1. A method for purifying phenol, comprising a step of passing first impurities comprising phenol, acetone and hydrocarbon, which are prepared using cumene as a raw material, through a plurality of distillation columns sequentially and performing azeotropic distillation,wherein the plurality of distillation columns comprise:
a crude acetone column (CAC) for receiving the first impurities comprising phenol, acetone and hydrocarbon and for separating and purifying acetone;
a crude phenol column (CPC) for receiving second impurities comprising phenol and hydrocarbon discharged from a bottom part of the crude acetone column, for discharging light impurities comprising phenol and light hydrocarbon from a top part, and for discharging heavy impurities including heavy hydrocarbon and phenol from a bottom part;
a hydrocarbon removal column (HRC) for receiving the light impurities comprising phenol and light hydrocarbon and performing azeotropic distillation, for discharging third impurities comprising phenol from a bottom part, and for discharging fourth impurities comprising light hydrocarbon from a top part; and
a phenol finishing column (PFC) for receiving the third impurities comprising phenol from the HRC and for productization, and
wherein a weight ratio of phenol and water at an uppermost part of the top part of the HRC in which the azeotropic distillation is performed is from 60:40 to 65:35, so that separation of the hydrocarbon can be optimized.

US Pat. No. 10,766,839

PROCESS FOR CONVERTING OLEFINS TO ALCOHOLS, ETHERS, OR COMBINATIONS THEREOF

Dow Technology Investment...

1. A process for converting olefins to alcohols, ethers, or combinations thereof that are suitable for use as a gasoline additive, the process comprising:(a) receiving a feed stream, wherein the feed stream comprises one or more olefins having 2 to 5 carbon atoms in an amount of up to 80% by weight based on the weight of the feed stream, wherein the feed stream comprises at least 50% by weight ethylene, propylene, and/or butene and at least 15% by weight alkanes:
(b) hydroformylating the feed stream in the presence of a catalyst to convert at least 80% of the olefins from the feed stream to oxygenates, wherein the catalyst comprises rhodium and at least one of organophosphorous ligand:
(c) separating a product stream from step (b) into an oxygenate stream and a stream comprising unreacted olefins, inerts, the catalyst, and the remaining oxygenates; and
(d) treating the oxygenate stream to convert a plurality of the oxygenates into at least one of an alcohol, an ether, or combinations thereof having at least 3 carbon atoms, wherein at least 25 weight percent of the alcohols and ethers having at least 3 carbon atoms are branched based on the total weight of the alcohols and ethers having at least 3 carbon atoms, and wherein the alcohols, ethers, or combination thereof is suitable for use as a gasoline additive.

US Pat. No. 10,766,837

METHOD FOR THE PRODUCTION AND PURIFICATION OF 2,3,3,3-TETRAFLUOROPROPENE

Arkema France, Colombes ...

1. A process for the production and purification of 2,3,3,3-tetrafluoropropene (HFO-1234yf) carried out starting from a starting composition comprising at least one compound of formula (I) CH(n+2)(X)m—CHp(X)(n+1)—CX(3+p?m), where X independently represents F or Cl; n, m and p are, independently of one another, 0 or 1 with n+m=0 or 1, n+p=0 or 1 and m?p=0 or 1, at least one X being Cl; said process comprising the stages of:a) bringing the starting composition into contact, in the presence of a catalyst, with HF under conditions effective in producing a composition A comprising HCl, a part of the unreacted HF, 2,3,3,3-tetrafluoropropene (HFO-1234yf), intermediate products B comprising 2-chloro-3,3,3-trifluoropropene (HCFO-1233xf), 1,1,1,2,2-pentafluoropropane (HFC-245cb) and trans-1,3,3,3-tetrafluoro-1-propene (HFO-1234zeE) and byproducts C comprising trans-1-chloro-3,3,3-trifluoro-1-propene (HCFO-1233zdE), cis-1-chloro-3,3,3-trifluoro-1-propene (HCFO-1233zdZ), cis-1,3,3,3-tetrafluoro-1-propene (HFO-1234zeZ), 1,1,1,3,3-pentafluoropropane (HFC-245fa), 2-chloro-1,1,1,3,3-pentafluoropropane (HCFC-235da), 1,2-dichloro-3,3,3-trifluoropropene (HCFO-1223xd), 2-chloro-1,3,3,3-tetrafluoropropene (HCFO-1224xe), 1,1,1,3,3,3-hexafluoropropane (HFC-236fa) and optionally one or more compounds of formula (II) CnHxFyClz in which n=4, 5 or 6, x is an integer from 0 to 6, y is an integer from 4 to 12, z is an integer from 0 to 6, with 2n=x+y+z if w is 1 or 2n?2=x+y+z if w is 2 or 2n+2=x+y+z if w is 0, w being the number of unsaturations in the compound of formula (II) considered;
b) recovering and purifying said composition A in order to form and recover a gas stream G1 comprising HCl, 2,3,3,3-tetrafluoropropene (HFO-1234yf), a part of the unreacted HF, a part of the intermediate products B and a part of the byproducts C; and a stream, which is liquid, L1 comprising a part of the unreacted HF, a part of the intermediate products B and a part of the byproducts C;
wherein said gas stream G1 is purified by the following stages:
b1) distilling the gas stream G1 in order to recover a stream G1a comprising HCl and a stream G1b comprising 2,3,3,3-tetrafluoropropene (HFO-1234yf), a part of the unreacted HF, said a part of the intermediate products B and said a part of the byproducts C;
b2-1) distilling said stream G1b obtained in stage b1) under conditions effective in forming a gas stream G1c comprising 2,3,3,3-tetrafluoropropene (HFO-1234yf), a portion of said part of said unreacted HF, a portion of said part of the intermediate products B and a liquid stream G1d comprising a portion of said part of the intermediate products B and said part of the byproducts C and a portion of said part of said unreacted HF; and
b2-2) distilling said stream G1d obtained in stage b2-1) under conditions effective in forming a stream G1d? comprising said portion of said part of the intermediate products B, said portion of said part of said unreacted HF and a portion of said part of the byproducts C comprising cis-1,3,3,3-tetrafluoro-1-propene (HFO-1234zeZ), 1,1,1,3,3,3-hexafluoropropane (HFC-236fa) and a part of trans-1-chloro-3,3,3-trifluoro-1-propene (HCFO-1233zdE) and 1,1,1,3,3-pentafluoropropane (HFC-245fa); and a stream G1d? comprising a portion of said part of the byproducts C comprising cis-1-chloro-3,3,3-trifluoro-1-propene (HCFO-1233zdZ), 2-chloro-1,1,1,3,3-pentafluoropropane (HCFC-235da), 1,2-dichloro-3,3,3-trifluoropropene (HCFO-1223xd), 2-chloro-1,3,3,3-tetrafluoropropene (HCFO-1224xe), and optionally one or more compounds of formula (II) CnHxFyClz in which n=4, 5 or 6, x is an integer from 0 to 6, y is an integer from 4 to 12, z is an integer from 0 to 6, with 2n=x+y+z if w is 1 or 2n?2=x+y+z if w is 2 or 2n+2=x+y+z if w is 0, w being the number of unsaturations in the compound of formula (II) considered.

US Pat. No. 10,766,835

SYSTEM AND METHOD FOR SEPARATION OF PROPYLENE AND PROPANE

SABIC GLOBAL TECHNOLOGIES...

1. A method for separating a feed stream comprising propylene and propane using a separation system comprising:i) a distillation column for producing a light stream comprising propylene and a heavy stream comprising propane,
ii) a reboiler for reboiling a part of the first heavy stream to produce a boiled heavy stream,
iii) a condenser for cooling the light stream to produce a condensed light stream, and
iv) an absorption refrigerator for receiving water and providing chilled water by the vaporization of a circulating refrigerant, wherein the absorption refrigerator is arranged to receive hot water from a waste heat source to provide heat for the circulation of the refrigerant, and provide cooled hot water,
wherein the condenser is arranged such that the cooling of the light stream occurs by the chilled water from the absorption refrigerator, wherein the method comprises the steps of:
a) feeding the feed stream to the distillation column and collecting a part of the first heavy stream from the separation system,
b) feeding a part of the heavy stream to the reboiler and feeding back the boiled heavy stream to the distillation column and
c) feeding back a part of the condensed light stream to the distillation column as reflux and collecting a part of the condensed light stream from the separation system;
wherein the hot water is quench water.

US Pat. No. 10,766,829

YEAST EXTRACT HAVING EFFECT OF PROMOTING GROWTH OF PLANT AND ELONGATION OF ROOT AND EFFECT OF IMPROVING ADDED VALUES OF PLANT

KOHJIN LIFE SCIENCES CO.,...

9. A method of cultivating a plant, comprising:spraying onto a leaf surface of a plant, or adding to soil or a hydroponic solution used in plant cultivation, a composition for plants containing a yeast extract having a peptide content of 5 wt % or more and an RNA content of 5 wt % or more.

US Pat. No. 10,766,828

LIQUID FERTILIZER COMPOSITIONS COMPRISING NICKEL, COBALT, AND MOLYBDENUM, AND METHODS OF FORMING AND USING THE SAME

1. A liquid fertilizer composition comprising a source of nickel, a source of cobalt, and monoethanolamine molybdate, said liquid fertilizer composition having a solution pH of about 6.0 to 7.5.

US Pat. No. 10,766,826

PROCESS FOR PRODUCING A FUEL FROM LIGNOCELLULOSIC FEEDSTOCK

Iogen Energy Corporation,...

1. A process for producing ethanol from lignocellulosic feedstock comprising:(i) treating the lignocellulosic feedstock to produce sugar, said treating comprising:
(a) pretreating the lignocellulosic feedstock with acid to provide an acid pretreated feedstock, said acid pretreated feedstock comprising cellulose; and
(b) hydrolyzing the cellulose to glucose, said hydrolyzing comprising adding enzyme to at least a portion of the acid pretreated feedstock;
(ii) fermenting at least the glucose to produce a fermented mixture comprising ethanol; and
(iii) recovering ethanol from the fermented mixture in one or more stages to produce concentrated ethanol and still bottoms, said still bottoms comprising sulfur-containing salt derived from sulfur-containing process chemicals;
wherein a soil conditioning composition produced by recovering still bottoms in step (iii) comprises an organic component and an inorganic component, wherein said inorganic component comprises the sulfur-containing salt derived from the sulfur-containing process chemicals; and
wherein said soil conditioner composition is applied to land.

US Pat. No. 10,766,824

METHODS OF MINIMIZING PARTICLES ON WAFER FROM PLASMA SPRAY COATINGS

APPLIED MATERIALS, INC., ...

1. A method comprising:performing two or more successive thermal cycles on a ceramic article comprising a body and a ceramic coating on at least one surface of the body, wherein the two or more successive thermal cycles expand and contract the ceramic coating to weaken bonds of particles to the ceramic coating, and wherein each successive thermal cycle of the two or more successive thermal cycles comprises:
heating the ceramic article to a first target temperature of about 100° C. to about 150° C. at a first ramping rate;
maintaining the ceramic article at the first target temperature for a first duration of time; and
cooling the ceramic article to a second target temperature at a second ramping rate; and
responsive to performing the two or more successive thermal cycles, submerging the ceramic article in a bath for a second duration of time to remove the particles from the ceramic coating.

US Pat. No. 10,766,811

ION EXCHANGED GLASS WITH HIGH RESISTANCE TO SHARP CONTACT FAILURE AND ARTICLES MADE THEREFROM

CORNING INCORPORATED, Co...

1. An article comprising a glass material, the glass material having a thickness of less than about 1.5 mm, a compressive layer extending from a surface of the glass material to a depth of layer of at least 75 microns, an inner central region under a tension of up to about 75 MPa, and a Vickers crack initiation threshold of at least about 10 kgf, wherein the compressive layer is under a compressive stress of at least 250 MPa, wherein [(Al2O3 (mol %)+B2O3(mol %))/(? alkali metal modifiers (mol %))]>1.

US Pat. No. 10,766,810

TARGETED CHEMICAL STRENGTHENING OF GLASS ARTICLES

Apple Inc., Cupertino, C...

1. A glass article for an electronic device, the glass article comprising:a first region having a first surface roughness, wherein the first region defines a first compression layer having a first depth, wherein the first surface roughness has a corresponding surface roughness parameter Ra that is greater than 10 ?m; and
a second region having a second surface roughness less than the first surface roughness, wherein the second region defines a second compression layer having a second depth less than the first depth.

US Pat. No. 10,766,809

ION EXCHANGE PROCESSES AND CHEMICALLY STRENGTHENED GLASS SUBSTRATES RESULTING THEREFROM

Corning Incorporated, Co...

1. A glass article comprising:a glass substrate including a first ion-exchanged surface and a second ion-exchanged surface opposite the first ion-exchanged surface, the first and second ion-exchanged surfaces defining an average thickness therebetween;
a first compressive stress layer extending inward from the first ion-exchanged surface toward a center of the glass substrate comprising a first depth of layer DOL1, wherein DOL1 is greater than 25% of the average thickness of the glass substrate;
a second compressive stress layer extending inward from the second ion-exchanged surface toward the center of the glass substrate comprising a second depth of layer DOL2 less than DOL1; and
a second substrate is bonded to the first ion-exchanged surface.

US Pat. No. 10,766,808

COATED ARTICLE WITH LOW-E COATING HAVING LOW VISIBLE TRANSMISSION

GUARDIAN GLASS HOLDING S....

1. A coated article including a coating supported by a glass substrate, the coating comprising:first and second infrared (IR) reflecting layers comprising silver, the first IR reflecting layer being located closer to the glass substrate than is the second IR reflecting layer;
a first contact layer comprising NiCr located over and directly contacting the first IR reflecting layer comprising silver;
a dielectric layer comprising silicon nitride located over and directly contacting the first contact layer comprising NiCr;
wherein the dielectric layer comprising silicon nitride is split by a nonabsorbing splitting dielectric layer comprising zirconium oxide ZrO2, so that the splitting dielectric layer comprising zirconium oxide ZrO2 is located between and contacting a first portion of the dielectric layer comprising silicon nitride and a second portion of the dielectric layer comprising silicon nitride;
a second contact layer comprising NiCr located over and directly contacting the layer comprising silicon nitride;
the second IR reflecting layer comprising silver located over and directly contacting the second contact layer comprising NiCr;
a third contact layer comprising NiCr located over and directly contacting the second IR reflecting layer; and
another dielectric layer comprising silicon nitride located over and directly contacting the third contact layer comprising NiCr.

US Pat. No. 10,766,807

MACHINABLE AND CHEMICALLY TOUGHENABLE FLUORINE GLASS-CERAMIC

SCHOTT Glass Technologies...

1. A fluorine mica glass-ceramic, comprising:SiO2: 25-75 wt %;
Al2O3: 6-30 wt %;
Na2O: 3-30 wt %;
K2O: 0-15 wt %;
B2O3: 0.1-30 wt %;
MgO: 4-35 wt %;
CaO: 0-4 wt %;
F: 1-20 wt %;
ZrO2: 0-10 wt %;
P2O5: 1-10 wt %;
CeO2: 0-1 wt %;
SnO2: 0-1 wt %,
wherein P2O5+Na2O>5 wt %, and Al2O3+Na2O+P2O5>17 wt %, and,
wherein the glass ceramic has a microstructure comprising:
1). a glass matrix, and
2) at least one crystalline phase with the formula of (K,Na)1?xMg3(Al,B,P)1?xSi3+xO10F2, where x is 0 to 1,the glass ceramic is machinable and can be ion exchanged to achieve compress stress CS >300 MPa, and Dol >15 ?m.

US Pat. No. 10,766,805

EDGE POLISHING A GLASS SUBSTRATE AFTER CUTTING

SEAGATE TECHNOLOGY LLC, ...

1. A method comprising:projecting plasma onto an annular edge of a glass substrate, wherein the annular edge has a first roughness;
directing at least one laser beam onto the annular edge; and
guiding the plasma with the at least one laser beam to reduce the first roughness to a second roughness with the plasma, wherein the plasma reduces the first roughness without changing a roundness of the annular edge of the glass substrate.

US Pat. No. 10,766,804

GLASS FILM PRODUCTION METHOD

NIPPON ELECTRIC GLASS CO....

1. A method of producing a glass film, comprising:a conveying step of conveying a band-like glass film in a predetermined direction with a conveying device; and
a cutting step of melt-cutting the glass film into a first portion and a second portion with a cutting portion while conveying the glass film by the conveying step,
the cutting portion comprising:
a laser irradiation apparatus;
a first support configured to support the first portion;
a second support configured to support the second portion; and
an opening formed at a position between the first support and the second support and below the laser irradiation apparatus,
the cutting step comprising deforming the glass film so as to be convex downward through the opening, and radiating a laser beam from the laser irradiation apparatus to a position which is within a range of the opening, and which is prevented from coinciding with a top of the glass film.

US Pat. No. 10,766,803

METHOD FOR PRODUCING BENT GLASS ARTICLE, AND BENT GLASS ARTICLE

AGC Inc., Chiyoda-ku (JP...

1. A bent glass article comprising:a first main surface;
a second main surface;
an end face; and
a curvature part provided at least partially,
wherein a main stress difference near the end face in one of the main surfaces is 5 MPa or less.

US Pat. No. 10,766,802

FLEXIBLE 3D FREEFORM TECHNIQUES

National Tsing Hua Univer...

1. A process for making a three-dimensional article comprising a curved 3D surface, the process includes:dispensing a solidifiable material in a fluid state from a dispensing head onto a target area on a base member at predetermined ambient conditions to form band-shaped materials and sequentially build up multiple band-shaped materials into said curved 3D surface;
simultaneously with the dispensing of said solidifiable material, changing curvature of the dispensed band-shaped material in its longitudinal direction by applying a differential molding member in physical contact with selected positions on surfaces of the material dispensed at said target area and by varying geometric shape of the physical contact between the differential molding member and the material dispensed;
simultaneously with the dispensing of said material and the changing of band-shaped material curvature in the longitudinal direction, generating relative movements between said base member and a combination of said dispensing head and said differential molding member in free space, said relative movements creating curvatures along latitudinal directions of the dispensed band-shaped materials;
the dispensed band-shaped materials in combination forming said curved 3D surface with smooth curvature along directions of said relative movements as well as in directions perpendicular to the directions of said relative movements;
said differential molding member comprises a deformable member and said varying geometric shape of the physical contact is conducted by deforming said deformable member into shapes corresponding to said predesigned shapes.

US Pat. No. 10,766,801

METHOD FOR TREATING ANIMAL WASTE

EnviroKure Incorporated, ...

1. A method for producing a liquid fertilizer from animal waste, the method comprising:a) adjusting moisture content and pH of the animal waste to produce an animal waste slurry comprising at least about 75 wt % moisture and a pH of about 5.5 or above;
b) allowing components of the animal waste slurry to remain in contact for a period of time;
c) reducing particle size of solids in the animal waste slurry;
d) separating the animal waste slurry into a substantially liquid component and a substantially solid component; and
e) subjecting the substantially liquid component to one or more processing steps comprising (1) aging the substantially liquid component to facilitate breakdown of solids remaining in the substantially liquid component (2) removing part or all of solids remaining in the substantially liquid component, and/or (3) reducing particle size of solids remaining in the substantially liquid component, thereby producing the liquid fertilizer;
wherein steps b) through e) are conducted at a pH of about 5.5 or above.

US Pat. No. 10,766,800

REMOVAL OF NITRATES FROM GROUND WATER

1. A process for removal of nitrates from water, to produce (i) product water and (ii) a waste brine comprising sodium (Na+) concentration below about 250 mg/L and a chloride (Cl?) concentration below about 450 mg/, the process comprising the steps of:a. passing a sample of water through a nanofiltration (NF) membrane to obtain a NF permeate and a NF retentate;
b. passing the NF permeate obtained in step (a) through a reverse osmosis (RO) membrane to obtain an RO permeate and an RO retentate;
wherein steps (a) and (b) further comprise controlling NF and RO recovery ratios to result in RO retentate comprising waste brine having sodium (Na+) concentration below about 250 mg/L and a chloride (CI?) concentration below about 450 mg/L;
c. combining the NF retentate obtained in step (a) with the RO permeate obtained in step (b) so as to produce product water; and
d. discarding the RO retentate obtained in step (b).

US Pat. No. 10,766,799

METHOD FOR IMPROVING QUALITY OF AQUACULTURE POND WATER USING A NUTRIENT GERMINANT COMPOSITION AND SPORE INCUBATION METHOD

NCH Corporation, Irving,...

1. A method of adding bacteria to water used in an aquaculture application, the method comprising:providing a volume of nutrient germinant composition and a volume of bacteria spores, which may be premixed together as a nutrient spore composition or separate;
optionally mixing a portion of the nutrient germinant composition and a portion of the bacteria spores if separate to form the nutrient spore composition;
heating a portion of the nutrient spore composition to a temperature in a range of around 38° C. to 60° C. at or near a site of the aquaculture application;
maintaining the temperature in the range for an incubation period of around 2 minutes to around 6 hours to form a batch of germinated bacteria solution;
periodically repeating the heating and maintaining steps to form additional batches of germinated bacteria solution over the course of a treatment cycle;
dispersing each batch of germinated bacteria solution into the water used in the aquaculture application;
providing a nitrification enhancement agent;
dispersing the nitrification enhancement agent in the water contemporaneously with at least one of the batches of germinated bacteria solution; and
wherein the bacteria are useful for remediating the water by degrading organic waste and inhibiting the growth of pathogenic bacteria or the bacteria are probiotic for a species in the aquaculture application.

US Pat. No. 10,766,797

METHOD AND COMPOSITION FOR USE IN THE CYCLIC PROCESS FOR THE EFFICIENT GENERATION OF CHLORINE DIOXIDE IN DILUTE SOLUTIONS

TRUOX, INC., Alpine, WY ...

1. A method for determine the relative bromide concentration in an aqueous system of an aquatic facility using a cyclic process, the method comprising:the cyclic process comprising activating bromide ions with an oxidant to produce free bromine, the free bromine oxidizes chlorite ions to produce chlorine dioxide, and reducing at least some free bromine back to bromide ions,
applying a composition comprising a bromide donor and a tracer; the composition is applied to the aqueous system to sustain a bromide ion concentration ranging from 2 ppm to 5000 ppm;
monitoring the tracer to determine the relative concentration of bromide ion, and
sustaining the bromide ion concentration to ensure the cyclic process and subsequent microbiological efficacy is achieved.

US Pat. No. 10,766,796

CHEMICAL INJECTION AND CONTROL SYSTEM AND METHOD FOR CONTROLLING CHLORAMINES

UGSI Solutions, Inc., Po...

1. A method of automatically controlling chloramine concentration in a body of water contained in a reservoir, the method comprising:a) determining residual chloramine concentration in a first water sample obtained from the body of water;
b) automatically engaging a supply of chlorine to add chlorine to the body of water when:
i) the residual chloramine concentration in the first water sample is determined to be below a pre-determined residual chloramine concentration set-point; or
ii) the residual chloramine concentration in the first water sample is determined to be below a first chloramine concentration percentage of a pre-determined residual chloramine concentration set-point;
c) determining residual chloramine concentration in a second water sample obtained from the body of water after step b); and
d) automatically engaging a supply of ammonia and the supply of chlorine to add both ammonia and chlorine to the body of water if:
i) the residual chloramine concentration in the second water sample is determined to be below the residual chloramine concentration in the first water sample; or
ii) the residual chloramine concentration in the second water sample is determined to be below a second chloramine concentration percentage of the pre-determined residual chloramine concentration set-point,
wherein a controller, in operable communication with an analyzer and one or more computer-readable storage mediums containing programming instructions, automatically executes steps a)-d),
wherein the programming instructions comprise algorithm I for causing the controller to execute step b) i), or algorithm VIII for causing the controller to execute step b) ii):
Algorithm I: y Algorithm VIII: y<[(a)(x)]=add chlorine only, where y is the residual chloramine concentration determined in the first water sample, a is a percentage selected within a range of 99% to 80%, and x is the residual chloramine concentration set-point;
wherein the programming instructions further comprise algorithm II for causing the controller to execute step d) i) and after chlorine only was added to the body of water, or algorithm IX for causing the controller to execute step d) ii) and after chlorine only was added to the body of water:
Algorithm II: w Algorithm IX: w<[(b)(x)]=add chlorine and ammonia, where w is the residual chloramine concentration determined in the second water sample, b is a percentage selected within a range of 99% to 80%, and x is the residual chloramine concentration set-point.

US Pat. No. 10,766,795

ELECTROCHEMICAL DEVICES OR SYSTEMS COMPRISING REDOX-FUNCTIONALIZED ELECTRODES AND USES THEREOF

Massachusetts Institute o...

1. A method of separating at least one target molecule from a fluid source comprising:a. placing in a fluid source (i) a first electrode comprising a first solid substrate and a first redox species immobilized to the first solid substrate; and (ii) a second electrode comprising a second solid substrate and a second redox species immobilized to the second solid substrate, wherein the first redox species and the second redox species comprise chemically different metallocenes; and
b. applying an electrical potential across the first electrode and the second electrode such that the first redox species transforms to an oxidized state and selectively binds to a target electron-donating functional group of a target molecule present in the fluid source,
thereby separating at least one target molecule comprising the target electron-donating functional group from the fluid source.

US Pat. No. 10,766,794

RESOURCE RECOVERY METHOD USING DESALINATION WATER TREATMENT APPARATUS

KOOKMIN UNIVERSITY INDUST...

1. A resource recovery method using a membrane distillation water treatment apparatus including: a plurality of membrane distillation (MD) modules arranged in multiple stages ranging from a first stage to an n-th stage and submerged in raw water in respective raw water tanks arranged in multiple stages ranging from the first stage to the n-th stage, the MD modules discharging a portion of the raw water as vapor; and a plurality of heat exchangers arranged in multiple stages ranging from the first stage to the n-th stage, each heat exchanger performing heat exchange using the vapor supplied from a previous-stage MD module of the MD modules, thereby maintaining the raw water in each raw water tank at a predetermined temperature, the method comprising:a first step at which a raw water feeder feeds raw water to the first-stage raw water tank;
a second step at which a vapor generator supplies high-temperature vapor to the first-stage heat exchanger;
a third step at which the first stage heat exchanger performs heat exchange between the supplied high-temperature vapor and the raw water in the first-stage raw water tank, and the first-stage MD module changes a portion of the water into vapor and supplying the changed vapor to a subsequent-stage heat exchanger (second-stage heat exchanger);
a fourth step of repeatedly performing the third step for each of the raw water tanks sequentially in the order from the second state to the n-th stage;
a fifth step at which the raw water is feed to a crystallizer from the n-th stage raw water tank;
a sixth step at which a turbidimeter detects a turbidity of the raw water fed to the crystallizer from the n-th-stage raw water tank;
a seventh step at which a controller transits an operation signal to the crystallizer when the turbidity of the raw water detected by the turbidimeter becomes a predetermined reference value; and
an eighth step at which the crystallizer operated by the operation signal extracts crystals of valuable resources contained in the raw water fed to the crystallizer from the n-th-stage raw water tank.