US Pat. No. 10,506,761

SYSTEM AND METHOD FOR MODIFYING TIRE PRESSURE IN AGRICULTURAL EQUIPMENT

1. An agricultural vehicle comprising:a frame supported by a plurality of tires;a plurality of load sensors, each load sensor of the plurality of load sensors configured to measure a weight or loading parameter of a portion of the agricultural vehicle;a tire pressure monitoring sensor associated with at least one tire of the plurality of tires, the tire pressure monitoring sensor configured to measure the internal pressure of the associated at least one tire;
a processor operable to receive a signal from each load sensor of the plurality of load sensors and to determine a target tire pressure for the at least one tire;
a gas system operable to increase or decrease the tire pressure of the at least one tire in response to the signal from the processor;
an accumulator configured to store cotton; and
a module builder configured to form the cotton from the accumulator into a module,
wherein some sensors of the plurality of sensors are configured to cooperate to determine the weight of cotton distributed within the agricultural vehicle.

US Pat. No. 10,506,754

VARIABLE TOOTH COULTER BLADE WITH SIZED INSERTS

PRESCRIPTIONA TILLAGE TEC...

1. A coulter blade for altering soil and surface stubble, comprising:a discoidal coulter blade configured with a blade hub and a blade circumference, the coulter blade having a first lateral side and a second lateral side, the first lateral side and the second lateral side being planar and extending from the blade hub to the blade circumference and being parallel with one another, the blade hub configured for detachably mounting the discoidal coulter blade to an implement;
a plurality of teeth configured proximal to and integral with the blade circumference, each one of the plurality of teeth having a rounded gullet adjacent thereto, each one of the plurality of teeth and gullet having a cutting edge and a back edge extending toward the blade circumference to an upward point so that each one of the plurality of teeth forms an upward saber shape for piercing the soil and rotating the discoidal coulter blade, the back edge longitudinally opposite the cutting edge, the cutting edge and the back edge extending away from the blade circumference continuing to its adjacent gullet, the cutting edge configured to cut the surface stubble and the soil, the back edge configured for rotationally driving the discoidal coulter blade parallel to the surface as the soil acts on the back edge, the gullet being rounded to continue the cut begun by the cutting edge;
the cutting edge of a first half of the plurality of teeth and the gullet adjacent thereto being sharpened on a first lateral side and the cutting edge of a second half of the plurality of teeth and the gullet adjacent thereto being sharpened on a second lateral side, each tooth of the first half having two teeth of the second half planarly adjacent and each tooth of the second half having two teeth of the first half planarly adjacent thereby resulting in an opposing tooth bevel pattern and tooth bevel angle;
wherein the plurality of teeth is adapted to drive the coulter blade in a forward motion altering soil and surface stubble while simultaneously mulching, tiling and aerating the soil.
US Pat. No. 10,508,249

GREASE COMPOSITION FOR ROLLING BEARINGS AND ROLLING BEARING

KYODO YUSHI CO., LTD., F...

1. A grease composition for rolling bearings, comprising, with respect to the total mass of the composition, 75 to 90 mass % of a base oil, 8 to 20 mass % of a urea thickener and 0.1 to 5 mass% of a metal deactivator, wherein;the base oil is a mixture of a paraffinic mineral oil and poly-alpha-olefin at a mass ratio of 50/50 to 99/1, the base oil having an aniline point of 130° C. or more and having a kinematic viscosity at 40° C. of 15 to 200 mm2/s,
the urea thickener is at least one selected from the group consisting of diurea compounds represented by formulas (2) to (4)
R4—NHCONH—R2—NHCONH—R4  (2)
R4—NHCONH—R2—NHCONH—R5  (3)
R5—NHCONH—R2—NHCONH—R5  (4)
wherein R2 represents a bivalent aromatic hydrocarbon group having 6 to 15 carbon atoms; R4 represents a C10-26 alkyl group, and R5 represents a C5-7cycloalkyl group and the ratio of the number of moles of R4 to the total number of moles of R4 and R5, expressed by [100 x (the number of moles of R4) / (the number of moles of R4+the number of moles of R5)] is in the range of 50 to 90 mol % in the urea thickener, and
the metal deactivator is at least one selected from the group consisting of 1-[N,N-bis(2-ethylhexyl)aminomethyl]-4-methyl-benzotriazole, thiadiazole, 2-mercaptothiadiazole, 2,5-bis(alkyldithio)-1,3,4-thiadiazole, 2-mercaptobenzimidazole and 2-(decyldithio)-benzimidazole.
US Pat. No. 10,509,026

GENETICALLY ENCODED CALCIUM INDICATORS AND METHODS OF USE

Howard Hughes Medical Ins...

1. A nucleic acid molecule encoding a genetically encoded calcium indicator (GECI) polypeptide, wherein the GECI polypeptide comprises an amino acid sequence having at least 99% sequence identity to the sequence set forth in SEQ ID NO:8.
US Pat. No. 10,507,243

NANOPARTICLE COMPLEXES OF RITUXIMAB, ALBUMIN AND PACLTAXEL

Mayo Foundation for Medic...

1. An antibody-albumin nanoparticle complex, the nanoparticle complex comprising albumin, a rituximab antibody, and paclitaxel, wherein the nanoparticle complex has been pre-formed in vitro by mixing an aqueous albumin-paclitaxel nanoparticle with the antibody under conditions to form the nanoparticle complex, such that the nanoparticle complex has CD20 binding specificity, said complex having a diameter of between 0.1 ?m and 1 ?m.
US Pat. No. 10,508,267

MUTANT 3-HYDROXYBUTYRATE DEHYDROGENASE FROM ALCALIGENES FAECALIS AS WELL AS METHODS AND USES INVOLVING THE SAME

Roche Diagnostics Operati...

1. A mutant 3-hydroxybutyrate dehydrogenase (3-HBDH) from Alcaligenes faecalis with improved performance relative to the wild-type 3-HBDH, wherein the mutant comprises an amino acid sequence that is at least 80% identical to the amino acid sequence of SEQ ID NO: 1 (3-HBDH from Alcaligenes faecalis; wild-type 3-HBDH) or the amino acid sequence of SEQ ID NO: 2 (extended core sequence of wild-type 3-HBDH) andwherein the mutant has at least three amino acid substitutions relative to the wild-type 3-HBDH, wherein the amino acid at the position corresponding to
position 253 of SEQ ID NO: 1 is substituted with Ile (253Ile), Ala (253Ala) or Cys (253Cys),
position 233 of SEQ ID NO: 1 is substituted with Ser (233Ser), Ile (233Ile), Ala (233Ala), Pro (233Pro), Arg (233Arg), Thr (233Thr), Lys (233Lys), or Cys (233Cys), and
position 234 of SEQ ID NO: 1 is substituted with Thr (234Thr), wherein improved performance relative to the wild-type 3-HBDH is
increased thermal stability relative to the wild-type 3-HBDH; and/or
increased substrate affinity relative to the wild-type 3-HBDH; and/or
increased cofactor affinity.
US Pat. No. 10,508,275

METHOD FOR THE CONSTRUCTION OF SPECIFIC PROMOTERS

Synpromics Ltd., Edinbur...

1. A method for making a transcription-enhancing combined promoter cassette, the method comprising:(a) identifying a plurality of transcription factor regulatory elements (TFREs), wherein each of the plurality of TFREs is associated with a plurality of genes, each of which is differentially expressed in a particular cell type or tissue type, or under a particular condition;
(b) determining the frequency, length and SYN value for each of said plurality of TFREs provided in step (a), and selecting TFREs from among the plurality of TFREs provided in step (a), wherein each of the selected TFREs (1) is within 20 kilobases of more than fifty percent of the plurality of genes defined in step (a), and (2) has a SYN value larger than 0.3, wherein the SYN value of a TFRE is defined as frequency(1/length), wherein frequency is defined as the number of occurrences of a given TFRE being associated with any of the plurality of genes, divided by the total number of all TFREs associated with any of the plurality of genes, and wherein the frequency is its frequency within 20 kilobases of any of the plurality of the genes and length is the length in nucleotides of the TFRE;
(c) constructing a library of randomly combined elements by randomly combining TFREs selected in step (b); and
(d) inserting combined elements from the library of (c) in a vector with a minimum promoter and a reporter gene, thereby generating a transcription-enhancing combined promoter cassette.
US Pat. No. 10,507,252

NANOPARTICLE PROBES AND METHODS OF MAKING AND USE THEREOF

1. A nanoparticle probe comprising:a nanoparticle base structure; and
a slip bond moiety comprising a binding motif for a glycocalyx and having a binding strength to the glycocalyx of less than about 100 pN, wherein the slip bond moiety is configured to reversibly bind to the glycocalyx of a cell;
a polymeric tether functionalized to the nanoparticle base structure and to an associative moiety comprising a cell surface binding moiety configured to bind to a one or more of a cell surface protein, receptor, and/or biomarker of the cell with a binding strength of larger than 100 pN;
wherein the associative moiety preferentially binds to the protein, receptor, and/or biomarker of the cell based on the thickness of a glycocalyx layer of the cell.
US Pat. No. 10,509,310

PATTERNING DEVICES FOR USE WITHIN A LITHOGRAPHIC APPARATUS, METHODS OF MAKING AND USING SUCH PATTERNING DEVICES

ASML Netherlands B.V., V...

1. A patterning device carrying a pattern of features to be transferred onto a target portion of a substrate using a lithographic apparatus and a resist process, at least an area of the patterning device being free of radiation absorber material and configured to define features of the pattern in that area by phase differences alone, wherein an individual feature in the area is defined at least in one direction by a pair of edges between regions having a phase different than that between the edges, and wherein a distance between the pair of edges is at least 15% smaller than a size of an associated feature to be formed on the substrate in the resist process once adjusted by a magnification factor, if any, of the lithographic apparatus.
US Pat. No. 10,507,265

CANCELLOUS BONE PRODUCT INCLUDING VIABLE OSTEOGENIC CELLS

NuVasive, Inc., San Dieg...

1. A bone product, comprising:cancellous bone matrix essentially free of hematopoietic cells, said cancellous bone matrix including native, viable osteogenic cells;
demineralized bone matrix; and
a cryopreservative;
wherein the cancellous bone matrix has been treated to partially digest the cancellous bone matrix and enhance availability of the native, viable osteogenic cells for carrying out their osteogenic function.
US Pat. No. 10,507,524

METALLIC COPPER DISPERSION, METHOD FOR MANUFACTURING SAME, AND USAGE FOR SAME

ISHIHARA SANGYO KAISHA, L...

1. A metallic copper dispersion liquid comprising at least metallic copper particles having a gelatin on surfaces thereof, a polymeric dispersant, and an organic solvent, whereinthe polymeric dispersant has an amine value of 18 to 61 mgKOH/g, a glass transition point within a range of ?65.7 to ?8.7° C., and a specific heat capacity of 1.40 to 1.77 J/(g·K) at a glass transition point of the polymeric dispersant, and
the metallic copper particles have, in the dispersion liquid, a 50% cumulative particle diameter (D50) of 67 to 94 nm and a 90% cumulative particle diameter (D90) of 139 to 200 nm, wherein the gelatin on the surfaces of the metallic copper particles comprises a collagen peptide having a molecular weight of 3000 to 5000.
US Pat. No. 10,508,294

ASSAYS AND OTHER REACTIONS INVOLVING DROPLETS

President and Fellows of ...

1. A composition comprising a plurality of droplets in an emulsion, wherein a droplet of the plurality of droplets comprises a cell and a particle, wherein the particle comprises one or more reagents for facilitating a reaction on a nucleic acid molecule of the cell.
US Pat. No. 10,508,301

DETECTION OF 5-HYDROXYMETHYLCYTOSINE BY GLYCOSYLATION

THE UNITED STATES OF AMER...

1. A method comprising:contacting a mammalian nucleic acid sequence with an enzyme that utilizes a labeled glucose or a labeled glucose-derivative donor substrate to add a labeled glucose molecule or a labeled glucose-derivative to a 5-hydroxymethylcytosine in said mammalian nucleic acid sequence to generate a labeled glucosylated-5-hydroxymethylcytosine, wherein said enzyme comprises a beta-glucosyltransferase and wherein said labeled glucose or said labeled glucose-derivative donor substrate comprises a uridine diphosphate glucose (UDPG).
US Pat. No. 10,508,309

METHODS FOR DETECTING AND TREATING VARIANTS OF SEBORRHEIC KERATOSES

THE GENERAL HOSPITAL CORP...

1. A method of treating a keratoacanthoma in a subject, the method comprising(a) receiving the results of an assay distinguishing a keratoacanthoma cell(s) from a squamous cell carcinoma in a skin sample, wherein the results are generated by the steps of:
(i) assaying a level of FOXN1 in a skin sample obtained from a subject, wherein the skin sample is a skin biopsy taken from the part of the skin suspected of having a keratoacanthoma;
(ii) detecting an increase in the level of FOXN1 of at least 10% as compared to the level of FOXN1 in a sample of normal skin cells, thereby detecting a keratoacanthoma cell(s) in the skin sample, and
(b) administering a therapeutically effective amount of a composition comprising kaempferol, ellipticine, nutlin-3 or pyromycin to the subject.
US Pat. No. 10,508,054

TRANSPORT VEHICLE GLAZING WITH WATER REPELLENT AND ANTI-DUST COATING ASSOCIATED WITH A DETECTION DEVICE

SAINT-GOBAIN GLASS FRANCE...

1. A transport vehicle glazing comprising a first side to face an interior of a transport vehicle and a second side to face an exterior atmosphere, the second side being opposite the first side, at least one zone of the second side not wiped by windscreen wipers and facing the exterior atmosphere, and said at least one zone being located to face a detecting device placed in the interior of the transport vehicle,wherein the transport vehicle glazing comprises a substrate and a mineral oxide layer provided on the substrate,
the mineral oxide layer being of 0.1 to 20 ?m thickness, wherein 30% to 90% of the volume of the mineral oxide layer consists of 20 to 300 nm open pores that are distributed uniformly throughout the thickness of the mineral oxide layer, and a majority of the open pores are connected to one another, an internal surface and an external surface of the mineral oxide layer being functionalized with a compound containing a perfluoroalkyl or alkyl functional group, saturated with a hydrophobic oil that impregnates the functionalized porous layer and forms a film on the surface thereof, and
wherein the mineral oxide layer is made of silica and formed at least in the zone of the second side not wiped by windscreen wipers and facing the exterior atmosphere.
US Pat. No. 10,508,068

PRODUCTION METHOD FOR INCLUSION COMPOUND

NIPPON SODA CO., LTD., T...

1. A method for producing a thermodynamically stable crystal of a clathrate compound, comprising a mixing step of mixing the following component (A), component (B), and component (C); and a heating step:(A): a mixed solvent comprising a first solvent which is at least one solvent selected from the group consisting of water and methanol; and a second solvent which is at least one solvent selected from the group consisting of ethyl acetate, hexane, methyl ethyl ketone, and methanol, the second solvent being a solvent different from the first solvent,
(B): at least one compound selected from the group consisting of 1,1,2,2-tetrakis(4-hydroxyphenyl)ethane and 5-hydroxyisophthalic acid,
(C): at least one compound selected from the group consisting of 2-phenyl-4-methyl-5-hydroxymethylimidazole and 2-ethyl-4-methylimidazole.
US Pat. No. 10,508,083

SUBSTITUTED PIPERIDINE COMPOUND AND USE THEREOF

Takeda Pharmaceutical Com...

1. (2R,3S)-N-ethyl-2-(((cis-4-isopropylcyclohexyl)oxy)methyl)-3-((methylsulfonyl)amino)piperidine-1-carboxamide or a salt thereof.
US Pat. No. 10,508,087

CRYSTALLINE FORMS OF TRISODIUM SUPRAMOLECULAR COMPLEX COMPRISING VALSARTAN AND AHU-377 AND METHODS THEREOF

CRYSTAL PHARMATECH CO., L...

1. Trisodium [3-((1S,3R)-1-biphenyl-4-ylmethyl-3-ethoxycarbonyl-1-butylcarbamoyl) propionate-(S)-3?-methyl-2?-(pentanoyl{2?-(tetrazol-5-ylate)biphenyl-4?-ylmethyl}amino)butyrate] trihydrate in crystalline form.
US Pat. No. 10,508,140

PEPTIDE HAVING HAIR GROWTH-PROMOTING ACTIVITY AND/OR MELANIN GENERATION-PROMOTING ACTIVITY, AND USE THEREOF

CAREGEN CO., LTD., Anyan...

1. A peptide having an activity to stimulate hair production or melanogenesis, the peptide consisting of the amino acid sequence of SEQ ID NO: 1 or SEQ ID NO: 2, optionally wherein (i) the C-terminal end of the peptide is modified by the presence of an amino group or an azide group, or (ii) the N-terminal end of the peptide comprises a protecting group.
US Pat. No. 10,508,186

CHEMICAL RECYCLING OF POLYETHYLENE TEREPHTHALATE BY MICROWAVE IRRADIATION

The University of North C...

1. A method of making bis(2-hydroxyethyl) terephthalate (BHET) from polyethylene terephthalate (PET), comprising:(a) combining PET with ethylene glycol and a catalyst system to produce a heterogeneous reaction mixture, wherein the catalytic system comprises a catalyst and a microwave absorber, with the catalyst being selected from the group consisting of: zinc acetate, zinc chloride, manganese acetate, 1, 5, 7-triazabicyclo [4.4. 0] dec-5-ene (TBD), 1, 8-diazabicyclo [5. 4. 0]undec-7-ene (DBU), magnesium acetate, 4-dimethylaminopyridine (DMAP), and combinations thereof, and with the microwave absorber being selected from the group consisting of a sodium salt, lithium salt, potassium salt, calcium salt, a magnesium salt, or combination thereof; and then
(b) heating by microwave irradiation the reaction mixture to produce a reaction product comprising BHET.
US Pat. No. 10,508,204

SELF-HEALING COATING

The Board of Trustees of ...

1. An autonomic self-healing material comprisinga plurality of microcapsules having a first outer shell;
a photopolymer composition encapsulated within he first shell of the microcapsules; and
a Pickering emulsion of photo-protecting solid particles lining the inside wall of the first outer shell, wherein the first outer shell and Pickering emulsion of photo-protecting solid particles form a photo-protecting outer shell that absorbs or reflects electromagnetic radiation to effectively prevent curing of the encapsulated photopolymer composition;where the self-healing process is autonomically initiated when a region of the material is sufficiently damaged to induce rupturing of one or more microcapsules, which release the photopolymer composition in and/or around the damaged region, and the released photopolymer composition is exposed to electromagnetic radiation.
US Pat. No. 10,507,186

METHODS AND COMPOSITIONS PARTICULARLY FOR TREATMENT OF ATTENTION DEFICIT DISORDER

Purdue Pharma L.P., Stam...

when tested according to the USP paddle method, 100 rpm, at 37° C.; (i) starting with 900 ml simulated gastric fluid for 2 hours, (ii) followed by 900 ml phosphate buffer pH 6.0 for 4 hours, and (iii) for the 7th hour onwards, 900 mL of phosphate buffer pH 7.4; USP <711> Acceptance Table 2; andwherein the plurality of coated beads provides, in a fasted state, an in vivo methylphenidate Tmax0-4 of about 1.63 hours and a methylphenidate Tmax8-16 of about 12.5 hours.
US Pat. No. 10,511,039

SOLID STATE HYDROGEN STORAGE DEVICE AND SOLID STATE HYDROGEN STORAGE SYSTEM

Hyundai Motor Company, S...

1. A solid-state hydrogen storage device, comprising:a storage unit configured to store a first hydrogen storage material therein;
a heat medium pipe disposed in the storage unit including a heat medium;
a separating pipe disposed in the heat medium pipe including a second hydrogen storage material, wherein the second hydrogen storage material is enclosed in the heat medium; and
a first gas supply pipe connected with a storage vessel and the separating pipe,
wherein the first gas supply pipe supplies gaseous hydrogen included in a storage vessel to the separating pipe,
wherein the second hydrogen storage material releases heat during hydrogen absorption,
wherein heat is released from the second hydrogen storage material during hydrogen absorption, and
wherein the heat released during the hydrogen absorption is supplied to the first hydrogen storage material included in the storage unit through the heat medium included in the heat medium pipe, thereby releasing hydrogen from the first hydrogen storage material.