US Pat. No. 10,335,660

BALL RETURN DEVICE

1. A device for returning a thrown ball, comprising:a rim that is shaped and dimensioned to receive a ball;
an elastic reflector having a first open end and an opposite second end, wherein said first end is connected to said rim and defines an opening; wherein said elastic reflector is downwardly tapered from said first end to form a vertex at said second end; and wherein said reflector has an axis passing through the vertex of the reflector and the centroid of the opening of the reflector; and
a frame; and wherein
said rim and said vertex are connected to said frame;
a tension cord that connects the vertex of the reflector to the frame;
wherein the tension cord is connected at a first point on the tension cord to the vertex of the reflector and connected at a second point on the tension cord to the frame; and
wherein the reflector and the tension cord are under tension;
a tension cord fastener configured to connect the tension cord at a desired point along the tension cord to at least one of the frame and the vertex of the reflector;
wherein the tension cord is configured such that changing the point along the tension cord at which the tension cord is connected to at least one of the frame and the vertex of the reflector varies the degree of tension in the tension cord and varies the distance between the first end of the reflector and the second end of the reflector; and
wherein the tension cord fastener comprises a collar slidably mounted on the frame.

US Pat. No. 10,335,659

GOLF CLUB HEAD, METHOD FOR MEASURING PERFORMANCE OF THE SAME, AND METHOD FOR MANUFACTURING THE SAME

SUMITOMO RUBBER INDUSTRIE...

1. A golf club head comprising:a top portion;
a sole portion opposite the top portion; and
a striking face configured to impact a golf ball, the striking face comprising a face center and a variable thickness distribution such that the club head exhibits an Expected COR value of not less than 0.810, the Expected COR value being determined based on the following relationship:

wherein:
(a) a virtual rectangular evaluation region is superimposed onto the striking face, the virtual rectangular evaluation region comprising a first pair of horizontal sides having a length of 45 mm, a second pair of vertical sides having a length of 25 mm, and a geometric center that coincides with the face center;
(b) the virtual rectangular evaluation region is divided into 5 rows (m) having an equal height of 5 mm and is divided into 9 columns (n) having an equal width of 5 mm, thereby forming a matrix of bins having coordinates i and j;
(c) cij corresponds to an average COR value associated with bin i, j;
(d) pij corresponds to a bin-specific impact probability value in accordance with the following:
and(e) the golf club head exhibits a characteristic time no greater than 257 microseconds.

US Pat. No. 10,335,658

BASEBALL BAT CONTROL SYSTEM AND METHOD OF USE

1. A control apparatus for securing to a handle, the control apparatus comprising:a sleeve body that extends along an axis from a first end to a second end and is configured to removably attach to the handle, the sleeve body having:
an inner cavity for receiving the handle;
at least one protrusion extending away from the sleeve body from a proximal end at the sleeve body to a distal end that defines a distal tip;
wherein the distal tip extends past the first end and is at least level with the second end of the sleeve body along the axis;
wherein the sleeve body is elastic, thereby allowing flexibility for securing the sleeve body to the handle;
wherein the sleeve body alters a grip associated with the handle via the at least one protrusion; and
wherein the at least one protrusion provide leverage associated with the handle.

US Pat. No. 10,335,657

GOLF CLUB

SUMITOMO RUBBER INDUSTRIE...

1. A golf club comprising:a head;
a shaft; and
a grip, wherein
a forward club flex is greater than or equal to 140 mm,
a grip weight Wg is less than or equal to 30 g, and
when a weight of the head is denoted by Wh, and a weight of the club is denoted by Wc, Wh/Wc is greater than or equal to 0.72.

US Pat. No. 10,335,656

GOLF BAG WITH CLUB SPACING FEATURES

1. A golf bag configured to eliminate contact between golf club heads, comprising:a body including an elongated octagonal shape in a top view, a flat top surface in parallel with a flat bottom surface, and four pairs of opposing flat sides, each pair of opposing flat sides being in parallel to define an interior octagonal space;
a plurality of club openings formed through the top surface and spaced apart from each other by a distance greater than a length of a golf club head such that when golf club shafts are inserted into a respective one of the club openings the golf club heads of the shafts are disposed outside the golf bag and cannot contact a shaft of an adjacent golf club while the shafts rotate within the respective club opening; and
a plurality of bases disposed one above another and extending horizontally from one side of the interior of the bag to the other and from a front side to a rear side, each of the bases having a predetermined number and sequence of holes disposed therethrough such that adjacent golf clubs extending through aligned base holes and respective club openings are maintained at different heights such that adjacent golf club heads cannot contact each other during rotation within the holes.

US Pat. No. 10,335,655

GOLF CLUBS AND GOLF CLUB HEADS

Karsten Manufacturing Cor...

1. A golf club head, comprising:a golf club head body including a ball striking face, a top, a bottom, a heel edge, and a toe edge, wherein the ball striking face is constructed at least in part from a first material having a first hardness, and wherein the ball striking face further includes: (a) a first elongated channel extending from a top-to-bottom center line of the ball striking face toward the heel edge and from the top-to-bottom center line toward the toe edge (b) a second elongated channel separated from the first elongated channel at the ball striking face by a first portion of the first material, wherein the second elongated channel extends from the top-to-bottom center line of the ball striking face toward the heel edge and from the top-to-bottom center line toward the toe edge and (c) a first groove defining a first recess in the first portion of the first material between the first elongated channel and the second elongated channel, and wherein, at the top-to-bottom center line, a first edge of the first groove constitutes the first material and a second edge of the first groove opposite the first edge of the first groove constitutes a first fill material, wherein the first groove is adjacent the second channel and the second channel extends deeper into the club head, measured in a direction perpendicular to the ball striking face, than the first groove;
a first fill material partially filling the first elongated channel, wherein the first fill material has a different hardness than the first material of the ball striking face, wherein a first portion of the first fill material extends flush to the ball striking face and a second portion of the first fill material defines a second groove, and wherein a first edge of the second groove constitutes the first fill material and a second edge of the second groove opposite the first edge of the second groove constitutes the first fill material; and
the second fill material partially filling the second elongated channel, wherein the second fill material has a different hardness than the first material of the ball striking face, wherein a first portion of the second fill material extends flush to the ball striking face and a second portion of the second fill material defines a third groove, and wherein a first edge of the third groove constitutes the second fill material and a second edge of the third groove opposite the first edge of the third groove constitutes the second fill material, and wherein the first fill material is separate and independent from the second fill material.

US Pat. No. 10,335,654

GOLF CLUBS AND GOLF CLUB HEADS HAVING A CONFIGURED SHAPE

Karsten Manufacturing Cor...

1. A golf club head comprising:a wood type golf club head body including a ball striking face portion at a front side thereof, a rear side opposite the front side, a crown portion, and a sole portion;
the golf club head body comprising an imaginary XY coordinate axis,
wherein a Y-axis is defined in a front-to-rear direction perpendicular to a front tangent and a rear tangent through a geometric center of the golf club head, and
wherein an X-axis is defined in a heel-to-toe direction perpendicular to the Y-axis through the geometric center of the golf club head,
the golf club head body including:
a maximum breadth that extends from a forwardmost point of the ball striking face portion to a rearwardmost point of the rear side;
a maximum depth that extends from a topmost point of the crown portion to a bottommost point of the sole portion;
a first portion of the golf club head body that extends from the crown portion to the sole portion and includes a first depth of the golf club head body;
a second portion of the golf club head body that extends from the crown portion to the sole portion and includes a second depth that is less than the first depth;
wherein the sole portion of the golf club head body is configured so that it includes:
a sloped boundary portion that separates a sole region of the first portion from a sole region of the second portion, wherein the sloped boundary portion has a height of at least 2 mm and extends from the sole region of the first portion to the sole region of the second portion, thereby defining a transition in depth between the first portion and the second portion of the golf club head body;
further wherein the sloped boundary portion extends so as to define a rear heel quadrant of the golf club head body,
wherein the rear heel quadrant of the body is heelward of the Y-axis and rearward of the X-axis; and
wherein the first portion of the golf club head body is the rear quadrant of the golf club head body,
further wherein the first portion and second portion are configured so that a center of gravity of the golf club head body is positioned nearer to the rear heel quadrant than the toe edge or the front side,
wherein at least 26% of the mass of the golf club head body is in the first portion of the golf club head body.

US Pat. No. 10,335,653

METHOD OF MANUFACTURING GOLF CLUB HEADS

Callaway Golf Company, C...

1. A method comprising the steps of:providing an electrical resistance welder comprising a pair of electrodes;
placing between the pair of electrodes a golf club head comprising a first piece composed of a metal material and a second piece composed of a metal material, wherein the first piece is at least partially disconnected from the second piece;
applying power to a plurality of regions of the golf club head so that at least one weld bead forms between the first and second pieces;
removing the golf club head from the electrical resistance welder; and
finishing the golf club head.

US Pat. No. 10,335,652

GOLF CLUB HEAD

SUMITOMO RUBBER INDUSTRIE...

1. An iron-type golf club head comprising:a striking wall having a strike face and a rear surface opposite the strike face;
a perimeter-weighting element located about the periphery of the rear surface and forming a rear cavity;
a resilient insert comprising a recess, the resilient insert being located within the rear cavity and abutting the perimeter-weighting element and the rear surface of the striking wall; and
a constraining member comprising a rigid metallic material and having a retaining portion that is disposed at least partially in the recess of the resilient insert such that a portion of the resilient insert is in a compressed state.

US Pat. No. 10,335,651

IRON-TYPE GOLF CLUB HEADS WITH A DUAL-DENSITY INSERT

Karsten Manufacturing Cor...

1. An iron-type golf club head comprising:a top surface adjacent and above a ball striking surface configured for striking a ball, wherein the top surface defines an upper portion of the iron-type golf club head, a sole adjacent the ball striking surface and opposite the top surface, a heel side near a hosel, and a toe side opposite the hosel, the top surface having a width within a range of 6 mm and 8 mm and the sole having a width within a range of 8 mm and 16 mm; and
a rear surface opposite the ball striking surface having an upper blade portion, a blade interface portion, and a lower muscle portion,
wherein the upper blade portion is adjacent to the top surface and extends across the rear surface from the heel side of the rear surface to the toe side of the rear surface and further extends downward from the top surface to the blade interface portion,
wherein the blade interface portion extends across the rear surface from the heel side of the rear surface to the toe side of the rear surface and is a smooth arcuate surface extending between and in direct contact with both the upper blade portion and the lower muscle portion,
wherein the lower muscle portion extends across the rear surface from the heel side of the rear surface to the toe side of the rear surface and the lower muscle portion extends upward from the sole to the blade interface portion, and wherein the lower muscle portion has a thickness greater than the upper blade portion, wherein the upper blade portion has a substantially constant thickness;
a recess provided in the rear surface;
wherein the recess comprises a constant depth;
wherein the recess comprises a recess floor that is substantially planar;
wherein the recess comprises a perimeter wall;
wherein the perimeter wall comprises a perimeter wall height;
wherein the perimeter wall height is substantially constant; and
an insert received within the recess;
wherein the insert consists of at least two metallic materials;
wherein the insert is affixed within the recess by means of welding or brazing;
wherein at least a portion of the recess extends behind a location of a center of gravity of the iron-type golf club head,
wherein the insert has a first portion having a first density and a second portion having a second density which is less than the first density,
wherein the first portion and the second portion are located adjacent and contiguous to each other, and further wherein the second portion of the insert has a majority of its volume located on the heel side of the rear surface, and
wherein the first portion of the insert is located entirely within the lower muscle portion and the second portion is located within the upper blade portion, the blade interface portion, and the lower muscle portion.

US Pat. No. 10,335,650

GOLF CLUB HEAD WITH ADJUSTABLE CENTER OF GRAVITY

Callaway Golf Company, C...

1. A golf club head comprising:a body comprising a hosel, a striking face, a heel side, a toe side, a rear side, and a sole;
a rail comprising a stem and a ledge extending approximately perpendicular to, and away from, the stem; and
a slidable weight assembly comprising a weight body and a rotatable portion,
wherein the weight body comprises an upper portion, a base portion extending from and perpendicular to the upper portion, and at least one nub extending from and approximately perpendicular to the base portion,
wherein the rotatable portion comprises a body and a protrusion extending from a lower end of the body,
wherein the protrusion extends only partially around the body,
wherein the upper portion comprises an opening sized to receive an upper end of the body,
wherein the upper end of the body is permanently trapped within the opening,
wherein the stem extends from, and is approximately perpendicular to, the sole,
wherein the ledge is spaced from the floor, and
wherein rotating the rotatable portion causes at least a portion of the curved protrusion to slide under the ledge and reversibly fixes the slidable weight assembly to the rail.

US Pat. No. 10,335,649

GOLF CLUB

TAYLOR MADE GOLF COMPANY,...

1. A golf club comprising:a shaft having a proximal end and a distal end;
a grip attached to the shaft proximal end; and
a golf club head attached to the shaft distal end producing a club length of at least 41 inches and no more than 45 inches, the golf club head having:
(i) a face positioned at a front portion of the golf club head where the golf club head impacts a golf ball, wherein the face has a loft of at least 12 degrees and no more than 27 degrees, and wherein the face includes an engineered impact point and a top edge height, and the face has a center face progression of less than 0.525 inches;
(ii) a sole positioned at a bottom portion of the golf club head;
(iii) a crown positioned at a top portion of the golf club head;
(iv) wherein an outer shell defines a head volume of less than 250 cubic centimeters, and wherein the golf club head has a rear portion opposite the face and a front-to-back dimension from a furthest forward point on the face to the furthest rearward point at the rear portion of the golf club head;
(v) a bore having a center that defines a shaft axis which intersects with a horizontal ground plane to define an origin point, wherein the bore is located at a heel side of the golf club head and receives the shaft distal end for attachment to the golf club head, and wherein a toe side of the golf club head is located opposite of the heel side;
(vi) a blade length measured horizontally from the origin point toward the toe side of the golf club head a distance that is generally parallel to the face and the ground plane to the most distant point on the golf club head in this direction, wherein the blade length includes a heel blade length section measured in the same direction as the blade length from the origin point to the engineered impact point;
(vii) a club head mass of less than 230 grams;
(viii) a center of gravity located:
(a) vertically toward the top portion of the golf club head from the origin point a distance Ycg, wherein the Ycg distance is less than 0.65?;
(b) horizontally from the origin point toward the toe side of the golf club head a distance Xcg that is generally parallel to the face and the ground plane; and
(c) a distance Zcg from the origin toward the rear portion in a direction generally orthogonal to the vertical direction used to measure Ycg and generally orthogonal to the horizontal direction used to measure Xcg;
(ix) a first moment of inertia (MOIy) about a vertical axis through the CG of at least 2000 g*cm2;
(x) a second moment of inertia (MOIfc) about a vertical axis through the origin of at least 4250 g*cm2;
(xi) a ratio of the first moment of inertia (MOIy) to the club head mass is at least 14; and
(xii) a ratio of the second moment of inertia (MOIfc) to the club length is at least 95.

US Pat. No. 10,335,648

GOLF CLUB HEAD WITH HEEL-SIDE WEIGHT PLUG

Callaway Golf Company, C...

1. A golf club head comprising:a body comprising a face portion, a sole portion, a crown portion, a heel side, a toe side, and a heel-side opening extending into the sole portion;
a hosel comprising a hosel bore and an internal hosel flange extending into and at least partially encircling the hosel bore;
a shaft sleeve comprising a shaft sleeve tip end with an internally threaded opening;
a first weight plug comprising a wall, a base end, a plug flange opposite the base end, a side opening extending into the wall proximate the plug flange, and a through-opening extending from the base end to the side opening;
a screw comprising a head portion, a midsection, and a threaded tip portion sized to engage the threads of the internally threaded opening in the shaft tip end; and
a washer disposed between the head portion of the screw and the plug flange,
wherein the heel-side opening communicates with the hosel bore,
wherein the first weight plug is sized to fit within the heel-side opening, and
wherein, when the first weight plug is disposed within the heel-side opening and the shaft sleeve is disposed within the hosel bore, the screw connects the weight plug to the shaft sleeve so that the internal hosel flange is sandwiched between the plug flange and the shaft tip end.

US Pat. No. 10,335,647

METHOD OF MANUFACTURING GOLF CLUB HEAD HAVING STRESS-REDUCING FEATURES

Callaway Golf Company, C...

10. A method comprising:preparing a wax of a golf club head body, the wax of the golf club head body comprising a striking face section, a sole section extending from a lower edge of the striking face section, and a return section extending from an upper edge of the striking face section, the striking face section, sole section, and return section defining a hollow body interior, the return section comprising a receiving pocket, and the sole section comprising a through-hole;
preparing a wax of a solid rod comprising an upper end and a lower end;
inserting the solid rod into the through-hole and seating the upper end in the receiving pocket so that the solid rod is located within 1 inch of a rear surface of the striking face section measured along a vertical plane extending through a face center perpendicular to the striking face section;
bonding the solid rod to the body with an adhesive material to form a combined wax mold; and
casting a golf club head from the combined wax mold,
wherein the through-hole is aligned with the receiving pocket,
wherein the solid rod has a variable diameter,
wherein each of the upper end and lower end of the solid rod has a diameter of 0.140 to 0.170 inch,
wherein a midpoint of the solid rod has a diameter of 0.100 to 0.125 inch, and
wherein no portion of the solid rod makes contact with the striking face section.

US Pat. No. 10,335,646

GOLF CLUB FACE PLATES WITH INTERNAL CELL LATTICES

Karsten Manufacturing Cor...

1. A golf club head comprising:a faceplate having:
an inner skin;
an outer skin;
a first region; and
a second region;
wherein:
the first region comprises one or more cell lattices, wherein a cell lattice comprises a plurality of walls defining a plurality of cells bounded between the inner skin and the outer skin;
the second region comprises one or more cell lattices; and
a density of the plurality of cells decreases towards a target strike region of the faceplate.

US Pat. No. 10,335,645

GOLF CLUB HEADS AND METHODS TO MANUFACTURE GOLF CLUB HEADS

PARSONS XTREME GOLF, LLC,...

1. A golf club head comprising:a body portion having a toe portion, a heel portion, a top portion, a bottom portion, a rear portion, and a front portion;
a face portion having a thickness of less than or equal to 0.075 inch (1.905 millimeters);
a first interior cavity portion;
a second interior cavity portion separate from the first interior cavity portion; and
a port on the body portion connected to the first interior cavity portion, the port configured to receive a polymer material,
wherein the first interior cavity portion extends to the face portion and the second interior cavity portion extends to the rear portion,
wherein the first interior cavity portion is at least partially filled with the polymer material, and
wherein the polymer material is coupled to the face portion.

US Pat. No. 10,335,644

REINFORCED FACES OF CLUB HEADS AND RELATED METHODS

Karsten Manufacturing Cor...

1. A club head comprising:a front face,
the front face comprising a front surface and a back surface opposite the front surface; andone or more reinforcing structures;wherein:
the one or more reinforcing structures are coupled with the front face at the back surface;
the one or more reinforcing structures consist of a solidified welding material; and
the one or more reinforcing structures are devoid of an adjoining structure other than the back surface of the front face;
the front face comprises a front face material;
the solidified welding material comprises a filler material; and
the one or more reinforcing structures are coupled symmetrically about a center of the back surface.

US Pat. No. 10,335,642

GOLF BALL

SUMITOMO RUBBER INDUSTRIE...

1. A golf ball comprising a core, an inner cover positioned outside the core, a main cover positioned outside the inner cover, and an outer cover positioned outside the main cover, with a large number of dimples formed on a surface of the outer cover, whereina TH value X at a central point of the core, a TH value S at a surface of the core, a TH value M of the main cover, a TH value I of the inner cover, a TH value O of the outer cover, and an average Q are defined by the following formulas (1) to (6) from a radius Rc (mm) of the core, a Shore C hardness Hc at the central point of the core, a Shore C hardness Hs at the surface of the core, a thickness Tm (mm) of the main cover, a Shore C hardness Hm of the main cover, a thickness Ti (mm) of the inner cover, a Shore C hardness Hi of the inner cover, a thickness To (mm) of the outer cover, and a Shore C hardness Ho of the outer cover,
X=Hc×Rc×0.05  (1)
S=Hs×Rc×0.05  (2)
M=Hm×Tm  (3)
I=Hi×Ti  (4)
O=Ho×To  (5)
Q=(I+O)/2  (6), and
the TH value X, the TH value S, the TH value M, the TH value I, the TH value O, and the average Q satisfy the following formulas (7) to (10),
15?M?S?100  (7)
0.25 ?10?I?O?30  (9)
Q/X?0.8  (10).

US Pat. No. 10,335,641

GOLF BALL

Bridgestone Sports Co., L...

1. A golf ball comprising a core and a cover of one or more layer encasing the core, wherein, letting HU-A and HU-B be respectively the Martens hardnesses measured at positions 100 ?m and 200 ?m inward from a surface of an outermost layer of the cover and toward a center of the core, and letting HU-C be the Martens hardness measured at a position 100 ?m from an inner side of the outermost cover layer and toward the surface, HU-A or HU-B is harder than HU-C, wherein the value of HU-A is from 14.8 to 53.4 N/mm2 and the value of HU-B is from 13.6 to 45.2 N/mm2.

US Pat. No. 10,335,640

GOLF BALL DIMPLE SURFACE

Acushnet Company, Fairha...

1. A golf ball having a plurality of recessed dimples on the surface thereof, wherein at least one of the dimples has a chord depth of from 0.001 inches to 0.030 inches and a dimple surface defined by a Bessel function with a membrane fixed at the boundary, wherein the Bessel function is of the mth order wherein m=2 and n=1.

US Pat. No. 10,335,638

TURNING PLATE FOR MEASURING THE PUSHING-OFF FORCES OF SWIMMERS

Kistler Holding AG, Wint...

1. A turning plate for measuring push-off forces of swimmers during turning in a swimming pool defined in part by a pool wall that is disposed generally normal to a pool edge, comprising:a stiff plate,
at least four force sensors for detecting the push-off forces applied by swimmers to the stiff plate,
a stiff, rectangular frame on which the plate is mounted on in at least four locations under pretension with a respective clamping screw and a respective force sensor.

US Pat. No. 10,335,634

ROLLER EXERCISE DEVICE

Samir Hanna Safar, San D...

1. A roller exercise device, capable of being placed on a flat support surface, comprising:a pair of roller support members, designated as a left roller support member and a right roller support member,
each roller support member having a semi-cylindrical configuration and a flat side surface, such that the flat side surface is placed on the support surface;
a cylindrical core roller member configured to support at least a portion of a user's body above the support surface during an exercise activity,
wherein the cylindrical core roller member is centrally and parallelly positioned in between the left roller support member and the right roller support member;
a bottom rest unit, said bottom rest unit further comprising:
a cushion member, a cushion base member, a plurality of carriage wheels, a plurality of carriage track members, a plurality of bottom rest support members, a position locking means wherein the position locking means comprises a mechanical fastener to secure the bottom rest supports with carriage track members;
a head rest unit configured with a central depression,
a core roller support member, configured as cylindrical elongated member, having a first end and a second end,
wherein the core roller support member is coaxially positioned and connected to the head rest unit at the first end, and the cylindrical core roller member at the second end, such that cylindrical core roller member is coaxially rotatable around the core roller support member;
a base support assembly, said base support assembly further comprising a plurality of structural support members,
wherein each structural support member has at least one flat surface configured to rest on the support surface and said plurality of structural support members are positioned below and non-removably attached to the left roller support member, the right roller support member, the cylindrical core roller member, the bottom rest unit and the head rest unit at predetermined locations.

US Pat. No. 10,335,633

DETACHABLE SPEED DETERMINING DEVICE CAPABLE OF COMPUTING ACCURATE SPEED INFORMATION OF A BICYCLE AND FIXING A BIKE COMPONENT OF THE BICYCLE

PixArt Imaging Inc., Hsi...

1. A detachable speed determining device, comprising:an optical detecting module adapted to determine axial rotational displacement of a bike component by detecting a movement of a pattern on the bike component;
an energy generating module adapted to generate energy;
an energy storage module sealed inside a housing of the detachable speed determining device in a water-resistance manner and electrically connected with the optical detecting module and the energy generating module, the optical detecting module being powered by the energy storage module, and the energy storage module being charged by the energy generating module;
a bolted joint connected with the optical detecting module and the bolted joint detachably passing through a rotation axle of the bike component; and a quick releasing handle foldably disposed on the bolted joint and including the energy generating module and the energy storage module.

US Pat. No. 10,335,632

TREADMILL INCLUDING A DECK LOCKING MECHANISM

Nautilus, Inc., Vancouve...

1. A treadmill comprising:a frame;
a deck assembly including a front end portion pivotally connected to the frame, the deck assembly positionable in an operating position and a storage position;
a first tube connected to one of the frame or the deck assembly, the first tube defining an aperture and a slot spaced apart from each other along a length of the first tube, wherein the slot extends lengthwise along the length of the first tube;
a second tube connected to the other of the frame or the deck assembly and slidably connected to the first tube; and
a lock mechanism operative to lock the deck assembly in the operating position and the storage position, the lock mechanism comprising:
a pin operatively connected to the second tube and engageable with the aperture and the slot of the first tube; wherein:
engagement of the pin with the aperture locks the deck assembly in the storage position; and
engagement of the pin with the slot locks the deck assembly in the operating position while allowing incline adjustment of the front end portion of the deck assembly relative to the frame during operation of the treadmill, wherein the slot is dimensioned to receive at least a portion of the pin and allow the pin to slide within the slot.

US Pat. No. 10,335,631

EXERCISE APPARATUS

Cybex International, Inc....

1. An exercise apparatus comprising:a foot support suspended from above by a suspension assembly on a frame, the foot support being adapted to support a user in an upright position with the user's foot disposed on the foot support,
the foot support being movable by the user on the frame back and forth between a rearwardmost downward position and a forwardmost upward position through any one of a plurality of different arc segments of a master arcuate path,
each said different arc segment being defined by movement of the foot support between a corresponding different forwardmost upward position and different rearwardmost downward position,
a resistance assembly interconnected to the foot support, the resistance assembly being adapted to exert a resistance to movement of the foot support by the user,the foot support being interconnected to an arm having a handle manually graspable by the user that can be pushed or pulled by the user such that pushing or pulling on the handle by the user reduces or increases power or energy required by the user to move the foot support,an arc segment selection device interconnected to the foot support, the arc segment selection device being manually actuatable by the user to enable the user to select one of the plurality of different arc segments by exerting a selected amount or degree of manual force on the arc segment selection device,
one or more detectors adapted to detect one or more of force, energy or power exerted by the user over time on the foot support or to detect distance or velocity of travel of the foot support or of the resistance assembly, the one or more detectors sending signals that are indicative of one or more of the detected force, energy, power, time, distance or velocity to a processor,
the processor receiving and processing the signals from the one or more detectors to generate a visual display output of one or more of said force, energy, power, time, distance, velocity or other result calculable from said signals for display,
a user interface including a display of the visual display output in a location on the apparatus that is readily observable by the user,
the user interface including an interval button interconnected to the processor that is manually actuatable by the user to input and send a signal to the processor that is indicative of a preselected interval of exercise time and rest time,
wherein the processor includes control instructions that instruct the processor to send signals to the display to repeat the preselected interval of exercise time and rest time a preselected number of times.

US Pat. No. 10,335,629

EXERCISE APPARATUS AND METHODS

1. An exercise device, comprising:a rigid spherical structure having a hand-opening in the surface, a cavity in the approximate center of the spherical structure, and a passageway coupling the hand-opening and the cavity, wherein the hand-opening is relatively small and sized to accommodate insertion of a hand and forearm to permit only limited movement thereof during exercises, wherein the passageway increases in size toward the cavity, and wherein the cavity is relatively larger and sized to more freely accommodate the hand; and
a rigid handle laterally positioned in the cavity and affixed in the approximate center of the spherical structure.

US Pat. No. 10,335,627

METHODS OF RESISTANCE TRAINING TO ARM AND LEG MOVEMENTS WHILE RUNNING

1. A method for resistance training to arm and leg movement, comprising:a. connecting a horizontally oriented raised weight base to a moveable sled in a spaced apart relationship for supporting a plurality of removable weights mounted to the horizontally oriented raised weight base, the horizontally oriented raised weight base configured to align and support a plurality of removable weights on the horizontally oriented raised weight base; the moveable sled comprising:
(i) a front;
(ii) a back opposite the front;
(iii) a first base side connected between the front and back; and
(iv) a second base side connected between the front and back opposite the first base side;
b. mounting a agility box mounted over the moveable sled;
c. threading a first flexible and extendable one piece stretch cord through a plurality of aligned first upper rollers mounted on the agility box and through a first remote roller mounted to the moveable sled spaced apart from the agility box and connecting the first flexible and extendable one piece stretch cord to a first lockable pulley system bracket mounted to the agility box;
d. securing a static non-extending stretch cord between the moveable sled and a subject, wherein the static non-extending stretch cord is secured to at least one of: a waist and an upper torso of the subject;
e. pulling on the first flexible and extendable one piece stretch cord connected to the moveable sled by the subject to receive a first load of resistance causing a physiological change to a first targeted part of the subject and simultaneously receiving a second load of resistance to a second targeted part of the subject while pulling the moveable sled with the static non-extendable stretch cord.

US Pat. No. 10,335,624

FIRE EXTINGUISHING COMPOSITIONS AND METHOD

Tyco Fire Products LP, L...

1. A firefighting foam preservative composition, comprising:a suspension system comprising water and at least one suspension agent, which comprises glycol, glycol ether, polyethylene glycol, or a mixture of two or more thereof;
a first polysaccharide that is soluble in the suspension system, wherein the firefighting foam preservative composition includes 0.1 to 1.0 wt. % of the first polysaccharide;
a second polysaccharide that is insoluble in the suspension system but soluble in water alone, wherein the firefighting foam preservative composition includes 3 to 12 wt. % of the second polysaccharide;
wherein the foam preservative composition has a viscosity of 1000 cPs to 6000 cPs; and
wherein the ratio of water to suspension agent is at least 2:8.

US Pat. No. 10,335,622

SPRINKLER HEAD WITH SMA SPRING

1. A sprinkler head for use in a structure for the delivery of a liquid, said sprinkler head comprising:a housing defining an inlet passage;
a sleeve with a first portion positioned in said housing, wherein said first portion has a valve face that seals said inlet passage to close a liquid flow path;
a cap assembled to said housing;
a spray assembly assembled to a second portion of said sleeve;
a return spring positioned between said cap and said first portion, wherein said return spring applies a force between said cap and said first portion to seal said inlet passage to close the liquid flow path;
an SMA spring positioned between said cap and said spray assembly; and
wherein said sleeve is movable relative to said housing to open said liquid flow path due to activation of said SMA spring, wherein said SMA spring applies a force to said sleeve to move said sleeve to open said inlet passage to open said liquid flow path when said SMA spring is activated.

US Pat. No. 10,335,621

FLEXIBLE DRY SPRINKLERS

The Reliable Automatic Sp...

1. A flexible dry sprinkler comprising:(A) a flexible tube having an inlet end and an outlet end;
(B) an inlet attached to the inlet end of the flexible tube, the inlet having an inlet orifice;
(C) an inlet seal assembly configured to seal the inlet orifice;
(D) an inlet release unit provided in the inlet and configured to release the inlet seal assembly, the inlet release unit including a frangible member configured to support the inlet seal assembly in the inlet orifice;
(E) an outlet attached to the outlet end of the flexible tube, the outlet having an outlet orifice;
(F) an outlet seal assembly having:
(a) a thermally responsive element configured to fail when ambient temperature reaches a predetermined temperature; and
(b) an outlet seal that is supported by the thermally responsive element in the outlet orifice, and that seals the outlet orifice until the thermally responsive element fails; and
(G) a flexible linkage (a) having an inlet end and an outlet end, (b) extending between the inlet and the outlet through the flexible tube such that bending of the flexible tube causes bending of the flexible linkage, (c) translating, when the outlet seal is released, a predetermined distance from (i) a first position, in which the flexible linkage is supported by the outlet seal assembly, to (ii) a second position along an outlet direction from the inlet towards the outlet, and (d) operating, upon translating the predetermined distance, the inlet release unit by breaking the frangible member to release the inlet seal assembly.

US Pat. No. 10,335,619

FIREFIGHTER MULTIFUNCTION LADDER AND ESCAPE BELT

Fire Innovations LLC, Pe...

1. A multifunction escape and ladder belt, comprising:a front buckle having a first buckle member and a second buckle member, coupling apparatus to connect said first member to said second member, each of said first and second members having a slot through which a fabric side strap may be passed;
left and right adjustment buckles, each configured with rigid bars defining front, middle, and rear adjustment slots through which strap fabric portions may be passed;
left and right side straps, said left side strap connected at a first end to said first buckle member and having a second end threaded through said middle adjustment slot of said left adjustment buckle, then through said front adjustment slot of said left adjustment buckle, and said right side strap connected at a first end to said second buckle member and having a second end threaded through said middle adjustment slot of said right adjustment buckle, then through said front adjustment slot of said right adjustment buckle; and
a rear strap having an outward facing continuous back portion, a first end threaded through said rear slot of said left adjustment buckle and extending to a medial portion of said rear strap, a second end threaded through said rear slot of said right adjustment buckle and extending to said medial portion of said rear strap so as to put said first end and said second end in an overlapping configuration, and first and second energy-release double-loop portions, one of each formed in said rear strap proximate each of said left and right adjustment buckles forming a double-looped overlapping portion secured by stitching;
wherein said stitching forms a stitched strap connection having a predetermined minimum breaking strength.

US Pat. No. 10,335,618

BREATHING APPARATUS WITH ULTRAVIOLET LIGHT EMITTING DIODE

1. A breathing apparatus, comprising:a facemask portion sized to cover a lower portion of a wearer's face, the facemask portion comprising:
a flow chamber comprising:
a conduit, comprising:
a first opening disposed near a first end of the flow chamber;
a second opening disposed near a second end of the flow chamber; and
at least two internal walls that form a serpentine passage disposed between the first opening and the second opening, the serpentine passage including at least a first section in communication with the first opening, a second section connected by a first U-shaped bend with the first section, and a third section connected by a second U-shaped bend with the second section;
at least one light emitting diode configured to emit light having a peak wavelength in the ultraviolet range disposed in one of the first, the second, and the third sections of the conduit, wherein;
the at least one light emitting diode is disposed off center relative to a centerline of the one of the first, the second, and the third sections; and
the centerline is parallel to one of the two internal walls.

US Pat. No. 10,335,617

RESPIRATORY PROTECTION EQUIPMENT

1. A respiratory protection hood, comprising: a flexible bag adapted and configured to be slipped over a head of a user; and a reservoir of pressurized oxygen comprising an outlet orifice opening into an internal volume of the flexible bag, the outlet orifice being closed off by a removable or contrived-rupture stopper, wherein:the pressurized-oxygen reservoir comprises, upstream of the orifice, a passage for the pressurized gas and a valve needle able to move in a determined direction of travel in said passage;
the valve needle is subjected to two opposing forces in the direction of travel that are respectively generated, on one hand, by the pressure of the gas in the reservoir, and on the other hand, by a return member;
the valve needle has a cross section of determined profile that varies in the direction of travel in order to alter a degree of closure of the passage according to its position relative to the passage so as to regulate the flow rate of gas allowed to escape via the passage to the orifice as a function of time and as a function of the pressure of gas in the reservoir.

US Pat. No. 10,335,613

SYSTEMS, METHODS, AND DEVICES FOR COMMISSIONING AND QUALITY ASSURANCE DATA VALIDATION OF RADIATION THERAPY SYSTEMS

VARIAN MEDICAL SYSTEMS IN...

1. A method for determining commissioning data of a first radiation therapy device, comprising:obtaining, at a commissioning device, a first data set from the first radiation therapy device undergoing a commissioning process, the first data set including irradiation beam data from the first radiation therapy device and corresponding system parameters;
receiving, at the commissioning device, data from a plurality of already commissioned radiation therapy devices, said data being data obtained during respective commissioning of the plurality of radiation therapy devices, and including irradiation beam data from the plurality of radiation therapy devices and corresponding system parameters;
compiling the data received from the plurality of radiation therapy devices so as to allow for a direct comparison between the compiled data and the first data set;
performing an analysis of the first data set obtained from the first radiation therapy device with respect to predetermined limits and the compiled data;
generating a notification signal based on a result of the analysis;
determining an entity appropriate to receive the notification signal; and
communicating the notification signal to the appropriate entity for further processing,
wherein when the result of the analysis is that the first data set does not violate the predetermined limits and that a deviation from the compiled data is less than a predetermined threshold, the first data set is saved as the commissioning data for the first radiation therapy device and/or the first data set is sent to a dose calculation device for further processing.

US Pat. No. 10,335,612

PARTICLE BEAM TREATMENT SYSTEM, PARTICLE BEAM TREATMENT METHOD, AND COMPUTER PROGRAM PRODUCT

Kabushiki Kaisha Toshiba,...

1. A particle beam treatment system comprising:one or more hardware processors configured to function as:
a first calculator configured to calculate a respiratory movement signal indicative of an amount of displacement of an affected area attributed to respiration of a test subject, from a plurality of captured images in which a movement of the affected area is captured;
a second calculator configured to calculate a signal related to respiration of the test subject from a respiration detection output of a respiration sensor;
a model generator configured to generate a respiratory movement model obtained by synchronizing the respiratory movement signal with the signal related to respiration of the test subject and performing modeling;
an estimator configured to compare a measured signal related to respiration with the respiratory movement model, estimate a respiration phase of the measured signal related to respiration, and estimate the amount of displacement of the affected area corresponding to the estimated respiration phase;
a target value generator configured to generate a target value, which is used for performing movement control on a platform on which the test subject is lying down, on the basis of the estimated amount of displacement of the affected area;
a target value corrector configured to correct the target value in such a way that a control delay with respect to a position of the platform is absorbed;
an irradiation controller configured to control a particle beam treatment device to irradiate, with particle beams, the affected area of the test subject who is lying down on the platform which is subjected to movement control according to the target value that is corrected; and
a phase marker displaying unit configured to display, on a display, a phase marker indicative of a position of the affected area in accordance with the respiratory movement model and a signal waveform of the measured signal related to respiration.

US Pat. No. 10,335,611

GANTRY IMAGE GUIDED RADIOTHERAPY SYSTEM AND RELATED TREATMENT DELIVERY METHODS

ACCURAY INCORPORATED, Su...

1. A method, comprising:receiving a pre-acquired image data set of a target acquired in a reference frame generally independent of a reference frame of an image guided radiation treatment (IGRT) apparatus;
during a patient setup interval, positioning the target into an initial treatment position relative to the IGRT apparatus, the initial treatment position being along an axis of rotation of a rotatable gantry structure of the IGRT apparatus;
rotating the rotatable gantry structure through a range of gantry angles;
subsequent to the patient setup interval, operating a first x-ray cone beam imaging source and a first imaging detector to acquire a first population of x-ray cone beam projection images of the target for a respective first population of gantry angles and acquisition times;
processing the first population of x-ray cone beam projection images to compute therefrom a time sequence of sliding-window tomographic image volumes characterized in that each subsequent member of the time sequence is computed using at least one same x-ray cone beam projection image as used in computing at least one previous member of the time sequence, wherein the sliding-window tomographic image volume comprises a tomosynthesis reconstructed image volume; and
operating the IGRT apparatus to deliver treatment radiation to the target based at least in part on a comparison between at least one of the time sequence of sliding-window tomographic image volumes and the pre-acquired image data set.

US Pat. No. 10,335,609

MULTITUBE ESOPHAGEAL BRACHYTHERAPY CATHETER

THE CLEVELAND CLINIC FOUN...

1. A system for delivery of radiation to a target portion of a native tissue, the system comprising:a catheter comprising a catheter body having a proximal portion, a distal portion, and a longitudinally oriented lumen therebetween;
an expansion device disposed about at least a portion of the catheter body and having an expanded configuration and a non-expanded configuration;
an anchor balloon disposed about the catheter body distal to the expansion device and having an inflated configuration and a deflated configuration, the anchor balloon having a curved outer surface in an inflated configuration;
a plurality of tubes disposed about at least a portion of the expansion device and disposed only part-way along the longitudinal length of the anchor balloon along the curved outer surface, each of the plurality of tubes being configured to selectively guide exposure of a radiation source to the target portion of the native tissue.

US Pat. No. 10,335,607

IMPLANTABLE OPTICAL STIMULATION LEAD AND METHODS OF MAKING AND USING

BOSTON SCIENTIFIC NEUROMO...

1. An optical stimulation lead, comprising:a lead body comprising a distal end, a distal portion, and a proximal portion; and
an optical assembly attached to the distal end of the lead body and comprising
a light emitter,
a feedthrough assembly comprising at least one ceramic block, at least one feedthrough pin extending through the at least one ceramic block and electrically coupled to the light emitter, and a metal housing attached to the at least one ceramic block,
a metal tube attached to the feedthrough assembly and disposed around the light emitter, and
an emitter cover disposed over the light emitter and coupled to the metal tube.

US Pat. No. 10,335,606

USE OF TRANSCRANIAL MAGNETIC STIMULATION TO MODULATE PERMEABILITY OF THE BLOOD-BRAIN BARRIER

BRAINSWAY, LTD., Jerusal...

1. A method for modulating permeability of a blood brain barrier, the method comprising:providing a system for transcranial magnetic stimulation;
placing said system on a scalp; and
providing a series of magnetic pulses to a brain via the system, said providing done in a range of at least 0.2 Hz stimulation frequency, greater than 120% of resting motor threshold stimulation amplitude, and at least 100 stimulation pulses, wherein said series of magnetic pulses is configured to temporarily increase permeability of the blood brain barrier, wherein the temporary increase is for a period of at least 1 minute.

US Pat. No. 10,335,605

IMPEDANCE SPECTROSCOPY FOR DEFIBRILLATOR APPLICATIONS

ZOLL Medical Corporation,...

1. A defibrillation system for treating cardiac arrhythmia, comprising:a defibrillator having at least two electrodes and a charge storage device for administering electrotherapy, wherein the charge storage device is configured to administer the electrotherapy to a patient through the at least two electrodes and is configured to be located external to the patient;
a memory associated with the defibrillator and configured to store instructions for operation of the defibrillator; and
a processor associated with the defibrillator and configured to execute the instructions to perform operations comprising:
providing an alternating electrical signal to a patient through the at least two electrodes,
estimating a transthoracic impedance of the patient from the alternating electrical signal sampled immediately prior to charging the charge storage device;
charging the charge storage device to a target voltage level based on the transthoracic impedance,
selecting a schedule for applying resistance values for controlling a discharge of the charge storage device, and
executing the schedule for applying resistance values during the discharge of the charge storage device to control a shape of a waveform of the alternating electrical signal during application of electrotherapy to the patient.

US Pat. No. 10,335,604

APPARATUS FOR MONITORING A CARDIAC RHYTHM DURING CPR

KONINKLIJKE PHILIPS N.V.,...

1. An automated external defibrillator (AED) for use during cardiopulmonary resuscitation (CPR) comprising:an input of an ECG signal;
a user interface having at least one of an aural instruction output and a visual display;
an ECG analyzer in communication with the input and operable to determine a shockable cardiac rhythm in the presence of CPR-related signal noise artifact from the input;
a memory for storing instructions related to a CPR rescue protocol that includes a period for providing CPR compressions; and
a processor in communication with the ECG analyzer and the user interface, the processor operable to issue instructions via the user interface responsive to the determined shockable cardiac rhythm,
wherein the ECG analyzer is operable to determine the shockable cardiac rhythm in the presence of CPR-related signal noise artifact from the input with a sensitivity of greater than about 70% and a specificity of greater than about 95%,
wherein the input comprises a stream of digitized ECG signal data, and further wherein the ECG analyzer segments the ECG signal data corresponding to a predetermined time segment,
wherein the ECG analyzer further comprises a set of fixed-frequency band pass filters which operate to filter the CPR-related signal noise artifact from the ECG signal data,
wherein the ECG analyzer further comprises an algorithm which determines the shockable cardiac rhythm from both a measure of a filtered ECG signal data centered on one frequency at about 25 Hz and of a second filtered ECG signal data centered on a second frequency of about 35 Hz, and
wherein the ECG analyzer further determines that the cardiac rhythm is shockable if both the filtered ECG signal data and the second filtered ECG signal data are below respective predetermined thresholds.

US Pat. No. 10,335,603

MEDICAL DEVICES INCLUDING FLEXIBLE CIRCUIT BODIES WITH EXPOSED PORTIONS OF CIRCUIT TRACES ATTACHED TO ELECTRICAL CONTACTS OF COMPONENTS

MEDTRONIC, INC., Minneap...

8. A medical device, comprising:a housing;
a first circuit within the housing that generates stimulation pulses;
an electrical component within the housing and spaced from the first circuit, the electrical component having an electrical contact; and
a flexible circuit body within the housing and having at least one conductive circuit trace with an insulative body having a first external surface and a second external surface on an opposite side from the first external surface and with the first and second external surfaces covering the at least one conductive circuit trace, the at least one conductive circuit trace having a longitudinal axis and having a first portion that extends along the longitudinal axis and that is exposed from the insulative body in proximity to a first end of the insulative body by spanning a first window present in the first external surface and the second external surface of the insulative body and having a second portion that is exposed from the insulative body in proximity to a second end of the insulative body by spanning a second window present in the first external surface and the second external surface of the insulative body, with at least one of the first and second portions being attached to the electrical contact of the electrical component by a resistive weld to create an electrical connection between the first or second portion of the circuit trace and the electrical contact of the electrical component, and the circuit trace being electrically coupled to the first circuit.

US Pat. No. 10,335,602

HOLDER FOR AN IMPLANTABLE MEDICAL DEVICE

Boston Scientific Neuromo...

1. A medical device system, comprising:an implantable medical device (IMD) comprising a receptacle configured to connect with a connecting pin of an electrode lead cable, wherein, when the connecting pin of the electrode lead cable is inserted into the receptacle, lead connectors within the IMD contact mating conductors of the connecting pin, and
a holder comprising a compartment configured to hold the IMD, the holder further comprising an opening configured to allow the connecting pin to access the receptacle only when the IMD is contained within the holder in a keyed orientation;
wherein the IMD further comprises a housing comprising a conductive material and configured to operate as an electrode, and
wherein the holder comprises a window configured to provide contact between the housing and tissue of the patient when the holder and the IMD are implanted in the patient.

US Pat. No. 10,335,601

USER INTERFACE FOR CUSTOM PATTERNED ELECTRICAL STIMULATION

Boston Scientific Neuromo...

1. A neurostimulation system, comprising:a stimulation device configured to deliver neurostimulation pulses and to control the delivery of the neurostimulation pulses using a plurality of stimulation parameters;
a programming device configured to transmit the plurality of stimulation parameters to the stimulation device, the programming device including a programming control circuit configured to generate the plurality of stimulation parameters according to scheduled one or more neurostimulation programs each specifying a pattern of the neurostimulation pulses; and
a user interface coupled to the programming control circuit and including a display screen, a user input device, and a neurostimulation program circuit coupled to the display screen and the user input device, the neurostimulation program circuit configured to display a program creation area including a pulse train (PT) construction area and a train grouping (TG) construction area on the display screen, to create building blocks of the one or more neurostimulation programs including constructing PTs by temporally arranging one or more pulse blocks (PBs) in the PT construction area using the user input device and constructing TGs by temporally arranging one or more PTs selected from the constructed PTs in the TG construction area using the user input device, wherein constructing the TGs further includes receiving an order and a number of repetitions of the one or more PBs in each PT of the one or more PTs in the TG construction area using the user input device, to display a program scheduling area on the display screen, to schedule the one or more neurostimulation programs by temporally arranging one or more TGs selected from the constructed TGs for each program of the one or more neurostimulation programs and specifying one or more delivery times for the each program in the program scheduling area using the user input device, and to transmit the scheduled one or more neurostimulation programs to the programming device, the one or more PBs each including a plurality of pulses of the neurostimulation pulses.

US Pat. No. 10,335,600

CARDIAC DEVICE FOR TREATING BRUGADA SYNDROME

NEWSTIM, INC., La Lucila...

1. A cardiac device for treating Brugada syndrome, comprising:a cardiac pacing device comprising a pulse generator and a pair of pacing electrodes electrically coupled to the pulse generator via an endocardial lead and positioned in one of a region near the His bundle and a para-Hisian region of a patient's heart, the pulse generator configured to deliver at least two single-phased superimposed waveforms of opposite polarity through the pair of pacing electrodes relative to a reference electrode and substantially coincident to propagation of an activation wave front proceeding from the atrioventricular node of the patient's heart; and
a diagnostic module operatively coupled to the pulse generator and configured to sense via at least one sensing electrode physiology indicative of a presence of Brugada syndrome in the patient, the diagnostic module further configured to control the pulse generator in delivering the at least two single-phased superimposed waveforms in response to the presence of Brugada syndrome, wherein the physiology indicative of a presence of Brugada syndrome comprises an electrocardiogram that exhibits an ST segment elevation in the anterior precordial (V1, V2, V3) leads with QRS complexes exhibiting an image of right bundle branch block in the right precordial leads and an elevation at the J point.

US Pat. No. 10,335,599

METHOD AND APPARATUS FOR PROGRAMMING CHARGE RECOVERY IN NEUROSTIMULATION WAVEFORM

Boston Scientific Neuromo...

1. A method for neurostimulation, comprising:determining a stimulation waveform representing a pattern of neurostimulation pulses each including a charge injection phase;
generating charge recovery parameters based on a charge recovery scheme and one or more predetermined values of each parameter of one or more of the charge recovery parameters;
adjusting the determined stimulation waveform by automatically inserting charge recovery phases into the determined stimulation waveform to recover charges injected during the charge injection phases using the charge recovery parameters; and
programming a stimulation device for delivering the neurostimulation pulses according to the adjusted stimulation waveform.

US Pat. No. 10,335,597

SPINAL CORD STIMULATOR SYSTEM

Cirtec Medical Corp., Br...

1. A method of providing electrical pulse therapy to patient via an implantable spinal cord stimulation device, comprising the steps of:providing an implantable pulse generator with a microcontroller and an application specific integrated circuit (ASIC), wherein the ASIC comprises a digital circuit and an analog circuit;
receiving one or more commands sent by an external remote at a transceiver within the implantable pulse generator and transmitting the one or more commands to the microcontroller;
receiving, by the ASIC data representing the one more commands;
performing, by the digital circuit of the ASIC, signal processing in accordance with the one or more commands to generate one or more corresponding signals for the electrical pulse therapy, wherein the corresponding signals include timing information for the electrical pulse therapy; and
delivering the one or more signals for the electrical pulse therapy to an epidural space of a patient as directed by the analog circuit of the ASIC.

US Pat. No. 10,335,595

DYNAMIC CONTROL OF TRANSCUTANEOUS ELECTRICAL NERVE STIMULATION THERAPY USING CONTINUOUS SLEEP DETECTION

Neurometrix, Inc., Walth...

1. Apparatus for providing transcutaneous electrical nerve stimulation (TENS) therapy to a user, said apparatus comprising:a housing;
an application unit for providing mechanical coupling between said housing and the user's body;
a stimulation unit for electrically stimulating at least one nerve of the user;
a sensing unit for (i) sensing the body movement and body orientation of the user to determine whether the user is in an “out-of-bed” state or a “rest-in-bed” state, and (ii) analyzing sleep characteristics of the user during said “rest-in-bed” state; and
a feedback unit for at least one of (i) providing the user with feedback in response to said analysis of said sleep characteristics of the user, and (ii) modifying the electrical stimulation provided to the user by said stimulation unit in response to said analysis of said sleep characteristics of the user;
wherein said sleep characteristics comprise a likelihood measure of the sleep quality of the user.

US Pat. No. 10,335,594

DESENSITIZING DEVICE

GIMER MEDICAL CO., LTD., ...

1. A desensitizing device, comprising an electrical stimulation member; wherein the electrical stimulation member comprises:a controller for producing a stimulating signal, wherein the stimulating signal is a pulse signal having a frequency between 200 KHz and 800 KHz and its pulse repetition frequency is between 0 and 1 KHz;
at least two electrodes configured to be attached to a user's wrist and electrically connected to the controller to receive the stimulating signal from the controller and to apply the stimulating signal to a subcutaneous nerve via the skin, wherein the stimulating signal makes the at least two electrodes generate an electric field at least partially covering the subcutaneous nerve such that when the simulating signal is applied, the subcutaneous nerve is temporarily desensitized; and
a support member having an outer circumference, an inner circumference, a through channel surrounded by the inner circumference, and an accommodation space with a first opening on the outer circumference and at least two second openings on the inner circumference.

US Pat. No. 10,335,593

DEVICES AND METHODS FOR MONITORING NON-INVASIVE VAGUS NERVE STIMULATION

Electrocore, Inc., Baski...

1. A method for treating a medical condition of a patient, the method comprising:contacting an outer skin surface of the patient with a contact surface of a housing;
generating an electrical impulse within the housing;
transmitting, as the contact surface contacts the outer skin surface, the electrical impulse from the housing, non-invasively, through the outer skin surface, to a nerve at a target region within the patient such that the electrical impulse modulates the nerve;
measuring a physiological response of the patient, wherein the physiological response is directly associated with modulation of the nerve based on the transmitting; and
detecting, based on the physiological response, whether the electrical impulse was transmitted to the nerve.

US Pat. No. 10,335,592

SYSTEMS, DEVICES, AND METHODS FOR IMPROVING HEMODYNAMIC PERFORMANCE THROUGH ASYMPTOMATIC DIAPHRAGM STIMULATION

VisCardia, Inc., Beavert...

1. A method of improving hemodynamic performance of a heart, the method comprising:sensing a plurality of cardiac events directly from a diaphragm;
for each of the sensed cardiac events, determining whether the sensed cardiac event represents a valid cardiac event or a non-valid cardiac event;
establishing a diaphragmatic stimulation delay period based on a plurality of sensed cardiac events that are determined to be valid; and
delivering asymptomatic electrical stimulation therapy directly to the diaphragm based on the established diaphragmatic stimulation delay period.

US Pat. No. 10,335,591

AUDITORY SIGNAL PROCESSING

COCHLEAR LIMITED, Macqua...

1. A method, comprising:dividing an acoustic signal into first and second stimulation frames, wherein the first and second stimulation frames each include a stimulus period during which stimuli are delivered to electrodes of an auditory prosthesis and a wait period during which no stimuli are delivered to the electrodes of the auditory prosthesis;
determining a length for one or more of the wait periods of the first and second stimulation frames based on at least one feature of the acoustic signal; and
sequentially applying the first and second stimulation frames to the electrodes of the auditory prosthesis.

US Pat. No. 10,335,590

MRI COMPATIBLE LEADS FOR A DEEP BRAIN STIMULATION SYSTEM

The General Hospital Corp...

1. A lead for an implanted medical device in which the lead is adapted for electrical communication with an electrical signal source and has a distal tip with an electrode, the lead comprising:a wire adapted to be placed in electrical communication with the electrode, the wire including (i) a core comprising a polymeric material, (ii) a continuous metallic layer surrounding and contacting an outer surface of the core, the continuous metallic layer extending along the core a first length and having a layer thickness, and (iii) an outer metallic layer disposed on the continuous metallic layer, the outer metallic layer extending axially along the first length and having a first section and a second section, the first section defined by a first thickness greater than the layer thickness, the first section extending continuously and axially along the continuous metallic layer toward the second section, the second section having a second thickness greater than the first thickness and extending continuously and axially away from the first section, the first section having a first resistance and the second section having a second resistance different than the first resistance,
wherein the lead is substantially transparent to radio frequency waves in clinically-applicable magnetic resonance environments to reduce radio frequency absorption and avoid substantial heating effects.

US Pat. No. 10,335,588

UNWRAPPED 2D VIEW OF A STIMULATION LEAD WITH COMPLEX ELECTRODE ARRAY GEOMETRY

Medtronic, Inc., Minneap...

1. A lead comprising:a lead housing defining a longitudinal axis and a circumference;
a ring stimulation electrode disposed at a first axial position along the longitudinal axis of the lead housing; and
a plurality of stimulation electrodes disposed at respective different positions around the circumference of the lead housing, wherein the plurality of stimulation electrodes comprises at least three stimulation electrodes, and wherein the plurality of stimulation electrodes is disposed at a second axial position proximal from a distal end of the lead housing and different than the first axial position along the longitudinal axis of the lead housing.

US Pat. No. 10,335,587

WEARABLE BAND FOR LOW-FREQUENCY THERAPY

1. A low-frequency therapy wearing band 20 allowing a low-frequency therapy device 10 including a control box 11 constituted of a case, a power supply 12, a controller 13, a low-frequency wave output unit 14, and a control switch 15 to be connected thereto to provide a low-frequency stimulus to a body part of a wearer to enable physical therapy, the wearing band 20 comprising outer yarn 21 shaped as a cylinder by continuously knitting fiber yarn loops and knitted with fiber yarn, inner yarn 22 knitted with covering yarn, and pile yarn 23 formed of a conductive fiber, knitted at inner surfaces of the inner yarn 22, and applying a low-frequency stimulus while tightly contacting a skin, wherein a cable 16 of the low-frequency therapy device 10 is connected to electrode terminals 24 protruding from a surface to transmit a negative low-frequency current and a positive low-frequency current to the pile yarn 23, and wherein a stainless fiber 30 is knitted on an outside of the outer yarn 21 to prevent static electricity that occurs due to a contact to the wearing band 20.

US Pat. No. 10,335,586

IRREVERSIBLY CLOSABLE FLOW CONTROL CLAMP

Fenwal, Inc., Lake Zuric...

1. A flow control clamp for association with a tubing segment, the clamp comprising:a) a one-piece, integrally-formed body having a first leg and a second leg, each with a first end and a second end, the first end of the first leg and the first end of the second leg being interconnected, the first and second legs being movable from a first spaced-apart position to a second irreversibly-closed position;
b) a first aperture in the body located at the interconnection of the first ends of the first and second legs and a second aperture located in the second end of one of the first and second legs, the apertures being configured to permit the clamp to be received on the tubing segment, with the tubing segment passing through the apertures;
c) the first leg including a first inwardly-projecting contacting member and the second leg including a second inwardly-projecting contacting member opposed thereto, the first and second contacting members being configured to occlude the tubing segment when the first and second legs are in the closed position; and
d) the second end of each of the first and second legs including an engagement member, the engagement members cooperating to maintain the first and second legs in the closed position when the engagement members are brought into contact upon moving the first and second legs to the closed position.

US Pat. No. 10,335,585

PATIENT FLUID LINE ACCESS VALVE ANTIMICROBIAL CAP/CLEANER

Becton, Dickinson and Com...

1. A cap device for reducing risk of contamination of a patient fluid line access valve, the cap device comprising:a housing forming:
a first inner cavity which contains a first material storing an antimicrobial agent, the first inner cavity comprising a first opening through which an access portion of the patient fluid access valve may be inserted to contact the antimicrobial agent, and
a second inner cavity which contains a second material storing a cleaning solution, the second inner cavity having a second opening through which the access portion of the patient fluid access valve may be inserted to contact the cleaning solution; and
a wall interposed between the first and second inner cavities, said wall comprising:
a first surface opposite said first opening to said first inner cavity, and
a second surface opposite to said second opening to said second inner cavity.

US Pat. No. 10,335,584

PATIENT FLUID LINE ACCESS VALVE ANTIMICROBIAL CAP/CLEANER

Becton, Dickinson and Com...

1. A device for maintaining a patient fluid line access valve having an access portion with a distalmost end face that includes a septum and external threads on the access portion proximate the distalmost end face, the device comprising:a housing having an inner cavity, wherein an opening to the inner cavity is configured for receiving the access portion of the patient fluid tine access valve;
a material impregnated with a liquid antimicrobial agent prior to receiving the access portion of the patient fluid line access valve, wherein the material is disposed in the inner cavity;
threading protruding inwardly into the inner cavity from an inner wall of the housing near the opening, the threading configured to engage the external threads of the access portion of the patient fluid line access valve as the housing is placed over the access portion of the patient fluid line access valve to contact the material with the distalmost end face of the access portion of the patient fluid line access valve, and configured to disinfect the distalmost end face and at least a portion of the external threads of the access portion of the patient fluid line access valve with the liquid antimicrobial agent from the material,
wherein the threading receives the external threads of the access portion of the access valve thereby causing the distalmost end face to advance into the inner cavity such that the septum contacts the material.

US Pat. No. 10,335,583

CONDUIT CONNECTOR FOR A PATIENT BREATHING DEVICE

1. A connector assembly for a gas delivery conduit of a respiratory system, the respiratory system configured for providing respiratory gases to a patient, the connector assembly comprising:a first connector, the first connector comprising one or more locking tabs formed on an inner surface thereof, the one or more locking tabs protruding radially inward from the interior surface, the first connector coupled with a first conduit configured to transport respiratory gases from a flow generator or to a patient interface; and
a second connector, the second connector comprising:
a first aperture,
a second aperture, and
one or more locking fingers, the locking fingers configured to releasably attach with the one or more locking tabs of the first connector to removably couple the first connector and the second connector, the one or more locking fingers protruding longitudinally from the first aperture of the second connector, the second connector coupled with a second conduit configured to transport respiratory gases.

US Pat. No. 10,335,582

ALCOHOL PREP APPLICATOR

1. An improved applicator for application of an alcohol solution prior to medical procedures comprising:an applicator body comprising a top portion connected to a central portion, the central portion connected to a squeezable bladder, and the squeezable bladder connected to a bottom portion, the central portion and the squeezable bladder each defining a separate hollow internal chamber;
the hollow internal chamber of the central portion integral to the applicator body is designed to hold at least one cartridge having a plurality of swabs, each swab having a top portion for application of an alcohol solution;
the hollow internal chamber of the squeezable bladder integral to the applicator body is designed for holding alcohol solution and for holding at least one of the plurality of swabs, and the bladder capable of being squeezed to allow for an alcohol solution to fill an interior of the bladder and to release the solution from the bladder;
a spring-loaded hinge lever extending from the internal chamber of the central portion of the applicator body and extending outwards from the top portion of the applicator body for loading and ejecting individual swabs from the cartridge;
a hinge door positioned on the central portion of the applicator body, the hinge door being provided to load and remove the cartridge of swabs in the internal chamber of the central portion;
wherein the spring-loaded hinge lever is used to advance at least one swab from the cartridge held in the central portion through the bladder and then through an opening of the bottom portion of the applicator body for the application of alcohol solution to a patient's skin, such that only the top portion of the swab touches a patient's skin, causing the applicator to have minimal contact with a patient's skin;
wherein the internal chamber of the squeezable bladder can be partially or wholly filled with alcohol solution by squeezing the bladder, the squeezing of the bladder allowing a user to adjust the flow of alcohol solution on the patient's skin;
wherein the bladder is squeezed to release alcohol solution through the bottom portion of the applicator body, which is absorbed by the at least one swab protruding from the opening of the bottom portion of the applicator body; and
whereby the improved applicator allows for the application of an alcohol solution to a patient's skin with minimal contact, and allows the user to control and adjust the flow of alcohol solution to be applied to a patient's skin.

US Pat. No. 10,335,581

MEDICAL BALLOON INCLUDING PLEATS

Covidien LP, Mansfield, ...

1. A balloon for a balloon catheter comprising:a proximal cone section having proximal and distal ends, a length extending between the proximal and distal ends, an exterior surface having a generally conical shape, an interior surface, a wall thickness between the exterior and interior surfaces, and a circumference tapering proximally toward the proximal end of the proximal cone section;
a distal cone section having proximal and distal ends, a length extending between the proximal and distal ends, an exterior surface having a generally conical shape, an interior surface, a wall thickness between the exterior and interior surfaces, and a circumference tapering distally toward the distal end of the distal cone section; and
a balloon body section extending between and interconnecting the distal end of the proximal cone section and the proximal end of the distal cone section, the proximal and distal cone sections and the balloon body section defining an interior chamber configured to receive fluid to expand the balloon from a non-expanded state to an expanded state,
wherein one of the proximal and distal cone sections comprises grooves spaced apart around the circumference of said one of the proximal and distal cone sections, each groove having a length extending lengthwise of said one of the proximal and distal cone sections, a depth extending inward from the exterior surface of said one of the proximal and distal cone sections, and a width extending circumferentially of said one of the proximal and distal cone sections,
wherein the width of at least a portion of each groove tapers toward the balloon body section, and
wherein said one of the proximal and distal cone sections includes a plurality of ribs extending inward from the interior surface of said one of the proximal and distal cone sections at locations of the grooves on the exterior surface of said one of the proximal and distal cone sections such that each of the plurality of ribs extends at the respective location of each groove.

US Pat. No. 10,335,580

GUIDEWIRE WITH VARYING PROPERTIES

Abbott Cardiovascular Sys...

1. A method of making a medical guidewire core element comprising:providing a wire of nickel titanium alloy with superelastic properties having a proximal end and a distal end, wherein a first length separates the proximal end from the distal end;
applying cold work to the wire through a rotary swaging machine in a sequence that comprises:
swaging the wire over a second length that includes the distal end by using a die set having a first diameter wherein the second length is less than the first length;
swaging the wire over a third length that includes the distal end by using a die set having a second diameter, the third length being less than the second length, and the second diameter being less than the first diameter; and
applying a reducing process to the wire, following swaging the wire over the second length and the third length, whereby the wire is reduced to have a constant diameter over the first length wherein the reducing process includes applying centerless grinding.

US Pat. No. 10,335,579

INTRAVENOUS CATHETER APPARATUS

POLY MEDICURE LIMITED, F...

1. An intravenous catheter apparatus comprising:a catheter tube;
a catheter hub having a distal end and a proximal end, wherein the distal end is joined to the catheter tube and the proximal end defines a housing;
a needle extending through the catheter hub and the catheter tube and defining an axial direction, wherein the needle has opposite proximal and distal ends, the distal end forming a needle tip;
a needle hub attached to the proximal end of the needle;
a needle guard slidably arranged on the needle, wherein the needle guard is movably retained in the housing of the catheter hub, when the needle extends through the catheter hub and the catheter tube, wherein the needle guard is removable from the catheter hub once the needle tip is received in the needle guard upon withdrawal of the needle from the catheter tube, wherein the housing defines a chamber at one end thereof ensuring that a first and second arm of the needle guard do not engage or interact with an inner surface of the chamber prior and during venipuncture of a patient, wherein the catheter hub is made of two separate parts comprising a first part and a second part, wherein the first and second parts form the chamber, wherein the inner surface of the chamber is parallel to the axial direction and defined only by the second part, wherein the first part comprises a chamfered surface abutting the inner surface of the chamber, which chamfered surface is inclined towards the inside of the housing in a proximal direction of the catheter hub, and wherein the chamfered surface has a smaller inside diameter at its innermost end than a distance between outermost points of the arms in their deflected state inside the chamber.

US Pat. No. 10,335,578

CATHETER ASSEMBLY

TERUMO KABUSHIKI KAISHA, ...

14. A catheter assembly comprising:a hollow catheter;
a catheter hub to which the catheter is fixed;
an inner needle including a needle tip, the inner needle being detachably disposed inside of the catheter;
a needle hub to which the inner needle is fixed;
a catheter operation member configured to move the catheter relative to the inner needle; and
a support member disposed at the needle hub,
wherein the support member includes a support main body portion that is movable relative to the needle hub between (i) a first position at which the support main body portion contacts and supports the catheter, and (ii) a second position that is a different position from the first position, at which the support main body portion does not contact the catheter,
wherein the support member is rotatably attached to the needle hub, and
wherein the support member includes an axial rod portion rotatably attached to the needle hub, and the support main body portion projects in a direction orthogonal to an axial direction of the axial rod portion.

US Pat. No. 10,335,576

ANCHOR SYSTEMS AND METHODS

INTERRAD Medical, Inc., ...

1. A method for securing a catheter relative to a skin penetration point, comprising:inserting a catheter through a skin penetration point;
adjusting a first anchor and a second anchor of an anchor instrument from a first configuration to a deployed configuration, the first and second anchors being coupled to an external retainer device of the anchor instrument and being configured to extend distally away from a distal end of the external retainer device, wherein a first subcutaneous flexible tine of the first anchor and a second subcutaneous flexible tine of the second anchor are deployed in a subcutaneous region adjacent to an underside of a skin layer to secure the external retainer device relative to the skin penetration point;
inserting the first and second anchors of an anchor instrument through the skin penetration point while the catheter is occupying the skin penetration point;
connecting a removable cap member to the external retainer device; and
releasably engaging the external retainer device to an external portion of the catheter while the catheter is occupying the skin penetration point and while the first and second anchors extend distally away from the distal end of the external retainer device.

US Pat. No. 10,335,575

MEDICAL ELONGATED BODY

TERUMO KABUSHIKI KAISHA, ...

1. A medical elongated body, the medical elongated body comprising:a tubular body, which extends in an axial center direction, at least a part of the tubular body having a spiral slit, the tubular body including sites in which spiral inclination angles of the spiral slit in an extending direction of a spiral of the spiral slit with respect to a cross-section orthogonal to the axial center direction are different from each other, and a stepped portion in which a spiral inclination angle of the spiral slit changes with respect to the spiral inclination angle on one opposed surface side of a pair of opposed surfaces constituting the spiral slit, and an abutting portion on which the stepped portion abuts when the tubular body is twisted in a direction in which the spiral of the slit is released on the other opposed surface side of the opposed surfaces; and
a length of the stepped portion in the axial center direction is longer in a site having a first spiral inclination angle with respect to the cross-section orthogonal to the axial center direction than in a site having a second spiral inclination angle with respect to the cross-section orthogonal to the axial center direction, and wherein the first spiral inclination angle is greater than the second spiral inclination angle.

US Pat. No. 10,335,574

ACCELEROMETER-BASED CONTACT SENSING ASSEMBLY AND SYSTEM

St. Jude Medical, Atrial ...

1. A method comprising:providing a catheter having a proximal portion and a flexible distal portion, the proximal portion being stiff relative to the flexible distal portion;
providing an electrode coupled to the flexible distal portion, and an accelerometer coupled to the electrode; and
monitoring an output of the accelerometer to recognize when the electrode comes into contact with a tissue surface of an endocardial wall of a heart of the patient, and detecting when the electrode contacts the tissue surface by recognizing, using said accelerometer output, when the electrode motion corresponds to a motion of the tissue surface.

US Pat. No. 10,335,573

INTRAPERITONEAL CHEMOTHERAPY MEDICAL DEVICES, KITS, AND METHODS

Cook Medical Technologies...

1. A catheter, comprising:an elongate member having an elongate member proximal end, an elongate member distal end, and an elongate member main body extending between the elongate member proximal end and the elongate member distal end, the elongate member main body defining an elongate member circumferential wall, first, second, and third openings on the elongate member proximal end, a first heating lumen extending from the first opening toward the elongate member distal end, a second heating lumen extending from the second opening toward the elongate member distal end, and a treatment lumen extending from the third opening toward the elongate member distal end; and
a distal cap disposed on the distal end of the elongate member, the distal cap defining a terminating surface that terminates the treatment lumen and a return lumen extending and providing fluid communication between the first heating lumen and the second heating lumen;
wherein the treatment lumen comprises a blind passage and the elongate member circumferential wall defines a plurality of passageways providing fluid communication between the treatment lumen and an environment external to said catheter.

US Pat. No. 10,335,572

SYSTEMS AND METHODS FOR COMPUTER ASSISTED OPERATION

1. A monitoring system, comprising:a projector aimed at a retina, the projector providing three dimensional images with different depth view points;
a camera to capture vision and transmit the vision to the projector to sweep the retina with images associated with the vision;
a mobile device coupled to the projector;
sensors coupled to a body to detect pain based on biometric and physical conditions, the sensor having a wireless transceiver adapted to communicate with the mobile device; and
a software module to display information from the mobile device and the camera using the projector to provide sexual stimulation with explicit augmented or virtual reality views of sex organ body part of an adult entertainer during pain episodes to distract a patient from feeling the pain.

US Pat. No. 10,335,568

NECK STRAP, CROWN STRAP ASSEMBLY AND HEADGEAR FOR A BREATHING MASK

ResMed Limited, Bella Vi...

1. Neck strap for a headgear, comprising:a one-piece main body adapted to engage a patient's neck, the main body including:
first and second lower connection portions adapted to connect to respective first and second lower mask connection straps, and
first and second upper connection portions adapted to connect to respective first and second lateral crown straps,
wherein the main body comprises two opposing major side edges and two opposing minor side edges that interconnect the opposing major side edges,
wherein the first upper connection portion and the first lower connection portion are located along a first of the two opposing minor side edges, and wherein the second upper connection portion and the second lower connection portion are located along a second of the two opposing minor side edges, and
wherein, in a flat state of the main body, each of the opposing major side edges comprises a curved portion.

US Pat. No. 10,335,565

MEASURING RESPIRATORY MECHANICS PARAMETERS OF VENTILATED PATIENTS

1. A system for measuring respiratory resistance of a subject breathing with use of a ventilator comprising:an airflow perturbation device comprising:
a sealed housing having an airflow path, a first port at one end of the path, and a second port at an opposite end of the path, each configured to couple to a ventilator hose, wherein the housing is sealed against the atmosphere;
a perturbation mechanism positioned within the airflow path between the first and second ports, wherein the perturbation mechanism includes an element disposed in the airflow path and an actuator coupled to the element to control the element to intermittently create an obstruction to airflow and periodically alter airflow resistance between the first port and the second port;
a pneumotachometer comprising a flow sensor, a first pressure tap disposed proximate the first port and a second pressure tap disposed proximate the second port to measure airflow between the first port and the second port;
a pressure sensor to measure a difference in air pressure between the first port and the second port, wherein the pressure sensor is coupled to the first pressure tap to access pressure at a position between a mouth of the subject and the perturbation mechanism, and to the second pressure tap to access pressure at a position between the perturbation mechanism and the ventilator; and
a computing system comprising at least one processor configured to:
receive data from the flow sensor and pressure sensor; and
determine an airflow resistance based on the received data.

US Pat. No. 10,335,564

SYSTEM AND METHOD FOR CONTROLLING EXSUFFLATION PRESSURE DURING IN-EXSUFFLATION

KONINKLIJKE PHILIPS N.V.,...

6. A method to reduce airway collapse in a subject during in-exsufflation therapy the method comprising:generating, with a pressure generator, a pressurized flow of breathable gas for delivery to an airway of the subject;
generating, with one or more sensors, output signals conveying information related to one or more parameters of the pressurized flow of breathable gas;
controlling, with one or more processors, the pressure generator based on an in-exsufflation therapy regime and the output signals to apply the pressurized flow of breathable gas, the in-exsufflation therapy regime including an exsufflation pressure of the pressurized flow of breathable gas during exhalation of the subject;
determining, with the one or more processors, based on a percentage of an actual inhalation tidal volume of the subject during a first respiratory cycle, a target exhalation tidal volume for exhalation of the subject during a second respiratory cycle, the percentage being less than 100%;
monitoring, with the one or more processors, based on the output signals, an actual exhalation tidal volume of the subject during the second respiratory cycle;
detecting, with the one or more processors, based on the monitoring, an airway collapse of the subject, the detection of the airway collapse being based on a comparison of the actual exhalation tidal volume and the target exhalation tidal volume during the second respiratory cycle; and
responsive to the detection of the airway collapse, adjusting, with the one or more processors, the control of the pressure generator by adjusting the exsufflation pressure in the in-exsufflation therapy regime.

US Pat. No. 10,335,563

ACTUATOR FOR AN INHALER

3M Innovative Properties ...

1. An inhaler for delivery of a medicament, the inhaler comprising an actuator and a canister, said canister comprising propellant and medicament, the actuator comprisinga body, a stem post and fixing means for fixing the stem post in the body, wherein
the body comprises a delivery passage for delivery of a medicament and a canister opening for insertion of a canister having a metering valve with a valve stem,
the stem post comprises a stem socket for receiving the valve stem of a canister and comprises an orifice for discharging a medicament to the delivery passage, and wherein
the stem post is adapted and the body is adapted so that the stem post and body cooperate to define a transition chamber when the stem post is fixed in the body, wherein the transition chamber is situated between the stem socket and the orifice.

US Pat. No. 10,335,562

METERED DOSE DISPENSERS WITH POROUS BODY

3M Innovative Properties ...

1. A pressurized metered dose inhaler for dispensing an aerosol formulation comprising particles of a medicament suspended in liquefied propellant, the inhaler comprising an aerosol container equipped with a metered dose valve having entrances into the valve, where a formulation chamber is defined in part by internal walls of the container, the formulation chamber configured to contain multiple doses of the aerosol formulation, and wherein the inhaler further comprises a porous, fluid permeable, particulate semi-permeable body, the porous body comprising a material, and the material having a nominal pore size from about 125 micrometers to about 2000 micrometers, the porous body located within the formulation chamber adjacent to the metered dose valve; and wherein the porous body is configured and positioned relative to the valve such that the aerosol formulation must pass through a porous body region defined by the porous body en route into the valve when the metered dose inhaler is operated in an upright position, and a sampling region defined between the porous body, portion of the valve, and a portion of an internal wall of the container, so that, in use, aerosol formulation will be sampled from said sampling region into an internal chamber of the valve, wherein the porous body region has a volume at least equal to or greater than the volume of a metering chamber of the valve.

US Pat. No. 10,335,561

VALVE

1. A valve for an inhalation device comprising an interior volume that is delimited at least partially by a valve wall, a permanent opening as well as a valve functional area, whereby the valve functional area is configured to be at least almost closed below an opening pressure difference and to be open above the opening pressure difference such that above the opening pressure difference, a fluid can flow through the permanent opening into the interior volume and out of the valve functional area,wherein
the valve comprises an inversion protector that is configured to impede or prevent inversion of the valve wall,
the inversion protector comprises a reinforcing region of the valve wall,
the valve functional area is configured to have a slit below the opening pressure difference,
the reinforcing region is elongated and extends from an end of the slit or from a vicinity of the end of the slit along a shortest path or almost along the shortest path in a direction of the permanent opening, and
the valve wall is invertible, in the absence of the reinforcing region, when a surrounding pressure exceeds a pressure in the interior volume of the valve.

US Pat. No. 10,335,560

SINGLE HIGH DOSE DRY-POWDER INHALER AND METHOD

3M INNOVATIVE PROPERTIES ...

1. A dry-powder inhaler comprising:a housing comprising at least one air inlet to a first air passage and a second air passage extending from the first air passage and terminating in a mouthpiece; the housing thereby providing a continuous air passage through the at least one air inlet, the first and second air passages, and the mouthpiece;
a rigid, fixed, powdered-medicament reservoir comprising a base, the reservoir being associated with the first air passage, and together with the first air passage forming a powder chamber;
wherein air passing through the powder chamber travels substantially parallel to an upper surface of the reservoir and substantially parallel to powdered medicament positioned on the base in the reservoir, the upper surface of the reservoir having a surface area, and the reservoir having a volume, the surface area being at least 1 cm2, and the surface area to volume ratio being at least 1 cm?1 and not more than 10 cm?1;
wherein the dry-powder inhaler has a single respirable-dose delivery capability of at least 5 mg of the powdered medicament; and
wherein the dry-powder inhaler has a plurality of entrainment-modulating structures in contact with the powdered medicament in the reservoir.

US Pat. No. 10,335,559

COMBINED LARYNO-TRACHEAL ANESTHETIC AND STYLET DEVICE

1. A medication delivery device, the device comprising:a malleable conduit comprising an upstream end and a downstream end configured to deliver medication, wherein the conduit is reversibly deformable into a shape that facilitates intubation;
a dispenser comprising:
a housing comprising a reservoir, a first end and a second end, the first end of the housing attached to a syringe containing a medication, the syringe further comprising a plunger and a barrel for transferring the medication from the syringe to the reservoir; and
a releasing mechanism for releasing the medication from the reservoir;
a pressurizing mechanism for keeping the medication pressurized within the reservoir; and
a connector that provides fluid communication between the syringe and the upstream end of the conduit through the second end of the housing.

US Pat. No. 10,335,558

METHODS OF TREATMENT

PARION SCIENCES, INC., D...

1. An apparatus comprising:an entrainment chamber including a gas inlet and a first aerosol outlet, the gas inlet configured to fluidically couple a gas source to the entrainment chamber to produce an entrained aerosol flow at the first aerosol outlet;
a nozzle in fluidic communication with the first aerosol outlet of the entrainment chamber, the nozzle configured to alter the velocity of the entrained aerosol flow; and
a particle selection chamber defining a fluid pathway, the particle selection chamber including a second aerosol outlet and configured to produce an outlet aerosol flow at the second aerosol outlet, the particle selection chamber further configured to receive the entrained aerosol flow from the nozzle and into the fluid pathway, at least a portion of the fluid pathway including a tortuous path configured to remove aerosol particles in the entrained aerosol flow below a predetermined diameter such that a volumetric median diameter (VMD) of the outlet aerosol flow is less than a VMD of the entrained aerosol flow.

US Pat. No. 10,335,557

METHOD FOR MAKING PATCH-SIZED FLUID DELIVERY SYSTEMS

DEKA Products Limited Par...

1. A method for making a delivery device for delivering an infusion medium to a user, the method comprising:providing a first housing portion adapted to be secured to a user;
providing a second housing portion configured to be selectively engaged with and disengaged from the first housing portion to allow disposal of the first housing portion without disposing of the second housing portion;
supporting a reservoir on the first housing portion, the reservoir having an interior for containing a fluidic medium;
supporting a pumping chamber on the first housing portion, for containing the fluidic medium for expanding an expandable structure, wherein the expandable structure comprises a bellows structure;
coupling a conduit in fluid flow communication with the pumping chamber and an interior volume of the expandable structure; and
operatively coupling a drive device for selectively conveying the fluidic medium through the conduit, from the pumping chamber to the interior volume of the expandable structure, to selectively expand the expandable structure, when the first housing portion and the second housing portion are engaged.

US Pat. No. 10,335,556

APPARATUS AND METHODS FOR LOW-VOLUME MEDICAMENT DELIVERY

Genentech, Inc., South S...

1. A fitting for a fluid dispenser, the fitting having a longitudinal axis and comprising:a detent that is configured to limit longitudinal insertion of the dispenser into the fitting by contacting a terminal surface of the dispenser, a top of the detent defining a first tangent plane;
a seal that is configured to be deformed by the surface, into a sealing contact against the surface, the contact defining a second tangent plane substantially coplanar with the first plane when the surface abuts the detent, the first plane maintaining a fixed orientation relative to the top throughout deformation of the seal; and
a body that is configured to:
receive the surface; and
support the detent and the seal;wherein;the seal is seated in the body in a recess having a bottom; and
the body includes an interior proximal-facing facet that is disposed;
more proximal than is the bottom; and
more distal than is the top.

US Pat. No. 10,335,555

SINGLE-USE PNEUMATIC SAFETY SYRINGE PROVIDING GAS-DRIVEN NEEDLE RETRACTION

L.O.M. Laboratories Inc.,...

1. A method of using a retractable-needle syringe having a plunger slidably engaged within a barrel of the syringe and a needle initially fixed at a distal end of the syringe, the method comprising the steps of:inserting a downstream tip of the needle into a source of medicament to be injected into a patient;
applying an upstream force to the plunger to withdraw medicament through the needle from the source of medicament into the medicament chamber to load the medicament into the medicament chamber;
inserting the tip of the needle into the patient;
injecting the medicament into the patient through the needle by applying a downstream injection force to the plunger;
after the medicament has been substantially injected into the patient, applying a downstream post-injection force to the plunger to:
couple a needle port seal provided within a retraction lumen of the plunger with a needle header that holds the needle in its in initial fixed position; and
force a gas cell into contact with a perforator to rupture the gas cell, thereby releasing compressed gas that forces the needle port seal, the needle header and the needle upstream into the retraction lumen; and
allowing air in the lumen to be released through a vent hole as the needle port seal, the needle header and the needle are forced upstream into the retraction lumen.

US Pat. No. 10,335,553

CAP ASSEMBLY FOR A MEDICAMENT DELIVERY DEVICE

SHL MEDICAL AG, Zug (CH)...

1. A cap assembly for a medicament delivery device, the cap assembly comprising:a cap body arranged to be connected to the medicament delivery device for protecting and for removing a medicament delivery member shield, which cap body has an inner cap structure defining a channel extending along a central axis of the cap body, where the channel has an open end; and
a gripping member configured to be received in the channel with a friction fit and to receive a medicament delivery member shield, where the gripping member has a first axial position relative to the inner cap structure and a second axial position relative to the inner cap structure;
wherein the gripping member has a proximal end and a distal end, a first leg, a second leg, and a transverse portion extending distally from the proximal end and between the first leg and the second leg to define a cavity comprising a support structure,
wherein each of the first leg and the second leg having a respective proximal portion extending distally from the transverse portion and extending parallel to each other and having distal portions with proximal ends extending distally from the proximal portions,
wherein when the gripping member is in the first axial position, the proximal ends of the distal portions are bent radially outward from the central axis extending away from each other to define a mouth that has a larger opening than the open end of the channel and large enough to receive a medicament delivery member shield between the distal portions,
wherein when the gripping member is moved to the second axial position, the proximal ends of the distal portions are bent radially inward closing the mouth around medicament delivery member shield such that the mouth opening is smaller than the open end of the channel,
wherein movement of the gripping member from the first axial position to the second axial position is caused by proximal axial movement of the medicament delivery member shield and by contact of the medicament delivery member shield with the support structure within the cavity, and
wherein each distal portion being provided with a medicament delivery member shield gripper configured to engage with the medicament delivery member shield when the gripping member is moved from the first axial position to the second axial position.

US Pat. No. 10,335,551

NEEDLE ASSEMBLY AND DRUG INJECTION DEVICE

TERUMO KABUSHIKI KAISHA, ...

1. A needle assembly configured to be connected to a drug container that includes a drug ejection portion having a male tapered shape with an outer diameter that becomes smaller toward a distal end, the needle assembly comprising:a needle tube that includes, at a distal end, a needle tip configured to puncture skin;
a fitting portion having a fitting opening in which the drug ejection portion of the drug container is insertable, the fitting portion having a female tapered shape;
an intermediate portion located distal of the fitting portion;
a retaining portion that retains the needle tube; and
an elastic member comprising:
a main body portion located in the intermediate portion, wherein an outer diameter of the main body portion before insertion in the intermediate portion is larger than an inner diameter of an inner wall surface of the intermediate portion, such that the main body portion is contacted by the inner wall surface and retained in the intermediate portion in a liquid-tight manner,
a contact portion that contacts the needle tube such that a proximal portion of the needle tube protrudes from the contact portion toward the fitting opening, and
a deformation portion that extends from the contact portion toward the fitting opening and is configured to deform when the drug ejection portion of the drug container comes into contact with the elastic member,
wherein a length of the deformation portion is in a range of 35% or more and 50% or less with respect to a length of the elastic member, and
wherein a length of a portion of the needle tube that protrudes from the close contact portion toward the fitting portion is in a range of 45% or more and 245% or less with respect to the length of the deformation portion.

US Pat. No. 10,335,549

DEVICES, SYSTEMS AND METHODS FOR MEDICAMENT DELIVERY

kaleo, Inc., Richmond, V...

1. An apparatus, comprising:a housing;
a medicament container disposed within the housing
a plunger having distal end configured to move within the medicament container between a first position and a second position in repsonse to a first force;
a needle coupled to the medicament container, a portion of the needle configured to be disposed outside of the housing;
a needle sheath covering the needle; and
a sheath retainer removably coupled to the housing such a portion of the sheath retainer is disposed within the housing, the sheath retainer configured to be disposed about at least a portion of the needle sheath, the sheath retainer including a grip surface including a grip protrusion configured to receive a second force to move the sheath retainer in a distal direction relative to the housing, the sheath retainer including a retaining tab that engages the needle sheath and is configured to exert at least a portion of the second force against the needle sheath when the sheath retainer is moved in the distal direction, the portion of the second force removing the needle sheath from about the needle when the sheath retainer is removed from the housing in the distal direction, the sheath retainer including a lock protrusion configured to engage the housing to resist movement of the sheath retainer in the distal direction, an outer surface of the sheath retainer including an indicium indicating an order of operation for removal of the sheath retainer.

US Pat. No. 10,335,547

METHOD AND APPARATUS FOR CLOSED-LOOP CONTROL OF NERVE ACTIVATION

PURDUE RESEARCH FOUNDATIO...

1. An apparatus for activating one or more neurons in a patient at a desired activation level for a therapeutic purpose comprising:a transducer for stimulating the one or more neurons according to a set of stimulus parameter values;
a measuring electrode configured to measure an activation level yielded by the stimulation of the one or more neurons, the activation level representing at least one of (1) a percentage of activated neurons inside a nerve, (2) a percentage activation of organ function, or (3) a percentage inhibition of organ function;
a neuron activation comparator for comparing the measured activation level of the one or more neurons to the desired activation level of the one or more neurons; and
a closed-loop micro controller configured to autonomously predict, at a microprocessor, a particular set of stimulus parameter values to apply to form a stimulation pulse shape yielding the desired activation level representing a particular non-zero percentage of a particular non-zero percentage of at least one of (1) activated neurons inside a nerve, (2) organ function, or (3) inhibition of organ function,
the closed-loop micro controller is configured to autonomously derive the predicted set of stimulus parameter values to apply from measured patient characteristics,
the closed-loop micro controller is configured to autonomously generate an activation profile of one or more neuron types based on a measured physiological response to the stimulation according to the predicted set of stimulus parameter values,
the generated activation profile comprises, for each of two or more particular non-zero activation levels of each of the one or more neuron types, a plurality of sets of stimulus parameter values observed or predicted to yield the particular non-zero activation level,
the closed-loop micro controller is configured to autonomously derive the measured patient characteristics via a linear regression from at least one of (1) measurements by the measuring electrode of the activation level of each of the one or more neuron types for different electrical pulse durations and amplitudes and (2) measurements of organ function for different electrical pulse durations and amplitudes,
the closed-loop micro controller is configured to actively maintain the desired activation level at the particular non-zero percentage by adjusting the predicted set of stimulus parameter values to apply to stimulate the one or more neurons,
the closed-loop micro controller applies changes to the activation profile of the one or more neuron types over time based on the adjusted set of stimulus parameter values and is configured to adapt to the changes in the activation profile of the one or more neuron types to maintain the desired activation level by autonomously updating the measured patient characteristics based on at least one of (1) additional measurements by the measuring electrode of the activation level of each of the one or more neuron types for different electrical pulse durations and amplitudes and (2) additional measurements of organ function for different electrical pulse durations and amplitudes.

US Pat. No. 10,335,545

TIME DEPENDENT DRUG DELIVERY APPARATUS

1. A drug delivery apparatus, comprising:a drug reservoir that stores a drug therein;
a temperature sensitive component that is at least one of the drug, the drug reservoir, or a power source that powers the drug delivery apparatus;
a temperature sensor in thermal communication with the temperature sensitive component to sense a temperature of the temperature sensitive component;
a transcutaneous device; a pump coupled to the transcutaneous device to deliver the drug via the transcutaneous device; and
processor that:
(i) receives from the temperature sensor an initial sensed temperature of the temperature sensitive component prior to initial delivery of the drug,
(ii) calculates a time delay for the temperature sensitive component to reach, starting from the initial sensed temperature, a predetermined working temperature that is between 100 C and 37° C., and
(iii) initiates initial delivery of the drug by the drug delivery apparatus following expiration of the calculated time delay, regardless of the temperature of the temperature sensitive component following expiration of the calculated time delay.

US Pat. No. 10,335,544

PASSIVE RESTART Y-SITE

CareFusion 303, Inc., Sa...

1. A fluid delivery Y-site device comprising:a body having a chamber, a primary flow port, secondary flow port, and an exit flow port fluidly coupled to the chamber;
a valve guide having a lower portion that extends into the chamber, between the primary flow port and the exit flow port, and an upper portion that extends from the lower portion toward the primary flow port;
a valve positioned in the chamber, between the primary flow port and the valve guide, wherein the valve is moveable between the primary flow port and the lower portion of the valve guide; and
a float positioned within the chamber between the valve and the exit flow port, wherein the float comprises a protrusion, and wherein the float is configured to move based on a level of fluid in the chamber, such that the protrusion of the float extends through the valve guide and engages the valve to occlude the primary flow port.

US Pat. No. 10,335,542

FLUID-CONNECTION MECHANISM AND METHODS FOR PATCH-PUMPS

SteadyMed Ltd., Rehovot ...

1. A method of delivering a drug, the method comprising:removing a pin from a patch-pump assembly to automatically cause a penetrator to penetrate a seal of a prefilled drug-reservoir, the patch-pump assembly comprising the penetrator, the prefilled drug-reservoir, a fluid-passageway, a cannula-containing assembly, and a spring-based mechanism;
flowing the drug from the prefilled drug-reservoir to the fluid-passageway;
establishing fluid communication between the fluid-passageway and the cannula-containing assembly using the spring-based mechanism;
flowing the drug from the fluid-passageway to the cannula-containing assembly; and
delivering the drug subcutaneously to a subject using the cannula-containing assembly.

US Pat. No. 10,335,539

DEVICES AND METHODS FOR MODULATING MEDIUM DELIVERY

Osprey Medical, Inc., Mi...

1. A method for mechanically modulating a fluid medium delivered to a vascular site within a body of a patient, the method comprising:employing a system including:
a sterile medium container that contains the fluid medium;
an injector;
a delivery catheter configured to deliver the fluid medium from outside the body of the patient to the vascular site within the body of the patient;
a chamber disposed between the injector and the delivery catheter;
a first connector, said first connector being fluidly coupled to each of the injector, the chamber, and a second connector, wherein the first connector is fluidly coupled to the chamber via a first valve;
the second connector being fluidly coupled to the sterile medium container via a second valve, and the second connector being fluidly coupled to the delivery catheter, wherein the second connector resides between the first connector and the delivery catheter;
injecting the fluid medium from the injector to the first connector, wherein the first valve is open;
simultaneously accepting a portion of the injected fluid medium into the chamber, wherein said chamber comprises at least one surface that imparts a force on the fluid medium within the chamber;
delivering the fluid medium to the vascular site within the body of the patient through the delivery catheter at a flow rate that remains substantially unchanged during the injecting of the fluid medium; and
drawing the fluid medium from the sterile medium container and filling the injector with the drawn fluid medium, wherein the first valve is closed and the second valve is open.

US Pat. No. 10,335,538

SYSTEM AND TREATMENT METHOD TO INCREASE CIRCULATION AND PLURIPOTENCY OF STEM AND PROGENITOR CELLS WITHIN A PATIENT

1. A treatment method to increase circulation and pluripotency of stem and progenitor cells within a patient by a practitioner, the method comprises the steps of:(A) providing a medicinal-administration system including a syringe, an infusion device, and a tourniquet;
(B) identifying an accessible peripheral vein on an upper extremity of the patient;
(C) preparing a volumetric dosage of an oxygen-ozone mixture within the syringe of the medicinal-administration system;
(D) applying the tourniquet to a cannulation area on the upper extremity and inserting the infusion device into the accessible peripheral vein of the patient before step (E);
(E) transfusing the volumetric dosage of the oxygen-ozone mixture from the syringe, through the infusion device, and into the accessible peripheral vein of the patient at a specified rate by releasing the tourniquet from the cannulation area during step (E) after the practitioner witnesses a flash of blood within the cannulation area;
(F) targeting a renal system and/or bone marrow of the patient with the volumetric dosage of the oxygen-ozone mixture to create stem and progenitor cells within the renal system and/or bone barrow of the patient; and
(G) repeating steps (B) through (F) as a plurality of treatment sessions.

US Pat. No. 10,335,537

INTEGRATED STRONTIUM-RUBIDIUM RADIOISOTOPE INFUSION SYSTEMS

Bracco Diagnostics Inc., ...

1. An infusion system on-board a cart comprising:a first shielding compartment having a first opening through which a strontium-rubidium radioisotope generator can be inserted into and removed from the first shielding compartment;
a first door configured to provide access to the first shielding compartment and to close over the first opening;
a second shielding compartment having a second opening through which a waste bottle can be inserted into and removed from the second shielding compartment;
a radioactivity detector positioned to measure radioactivity of a rubidium radioactive eluate flowing through an eluate tubing line in fluid communication with an outlet tubing port of the strontium-rubidium radioisotope generator;
a computer configured to receive an input from a user for controlling operation of the infusion system, wherein the computer is in electronic communication with a screen display;
a shielded detector compartment configured to receive the radioactivity detector; and
wherein the computer of the infusion system is configured to:
pump saline from a saline reservoir into the strontium-rubidium radioisotope generator through an inlet tubing port of the strontium-rubidium radioisotope generator thereby generating the rubidium radioactive eluate that is discharged through the outlet tubing port,
fill an eluate reservoir in a shielded well with a test sample to a predetermined volume,
receive a strontium breakthrough test result of the test sample filled into the eluate reservoir in the shielded well, wherein the strontium breakthrough test result of the test sample filled into the eluate reservoir in the shielded well is determined with a second radioactivity detector;
not allow a patient infusion if the strontium breakthrough test result is greater than or equal to an allowed limit;
measure a radioactivity of the test sample with the radioactivity detector while the test sample is flowing through the eluate tubing line to the eluate reservoir in the shielded well;
measure a calibration radioactivity of the test sample with the second radioactivity detector while the test sample remains in the eluate reservoir;
compare the radioactivity of the test sample measured by the radioactivity detector with the calibration radioactivity of the test sample measured by the second radioactivity detector;
track a volume of saline in the saline reservoir;
not allow the patient infusion if the volume of saline in the saline reservoir is below a predetermined saline threshold;
track a volume of waste in the waste bottle;
not allow the patient infusion if the volume of waste in the waste bottle is above a predetermined waste threshold.

US Pat. No. 10,335,536

PEN-TYPE DRUG INJECTION DEVICE HAVING MULTIPLE-USE NEEDLE MODULE WITH NEEDLE CLEANING RESERVOIR

1. A medical injection device for apportioning set doses of a liquid drug, comprisinga housing supporting a cartridge containing the liquid drug,
a needle cannula having a distal part with a distal tip and an opposite proximal part and a longitudinal lumen there between, the needle cannula being mounted relatively to the housing such that the distal part extend in a distal direction and the proximal part extend in a proximal direction and into the cartridge,
a telescopically movable shield which is telescopically movable in relation to the housing and urged in the distal direction by a spring means operable between the telescopically movable shield and the housing, and wherein the telescopically movable shield carries a first cleaning reservoir containing a liquid cleaning solvent for cleaning at least the distal tip of the needle cannula between subsequent injections,
wherein the first cleaning reservoir distally is sealed by a distal seal and proximally by a proximal seal longitudinal spaced from each other to define a volume containing the cleaning solvent and wherein the first cleaning reservoir further is provided with an opening connecting the first cleaning reservoir with a second overflow reservoir to accommodate a volume expansion of the liquid cleaning solvent contained in the first cleaning reservoir, and
wherein a predetermined amount of liquid cleaning solvent is present inside the second overflow reservoir.

US Pat. No. 10,335,535

INJECTION DEVICE WITH A NEEDLE CANNULA

1. An injection device for injecting a pharmaceutical liquid drug containing a preservative, comprising:a housing supporting a cartridge permanently embedded in the injection device, the cartridge having an interior chamber containing the pharmaceutical preservative containing liquid drug to be injected,
a needle cannula permanently secured to the injection device, and usable for multiple injections and having a front part with a tip and a back part, which back part is adapted to be in liquid communication with the interior chamber of the cartridge, and
a telescopic needle covering shield, which distally is provided with a reservoir confining a predetermined volume of a liquid for cleaning at least the tip of the needle cannula between subsequent injections, and which telescopic needle covering shield is urged distally into a first position by a first resilient member and moved proximally against the bias of the first resilient member into a second position during injection;
the first position being a position in which, the tip of the front part of the needle cannula is located inside the reservoir, and
the second position being a position in which, the tip of the front part of the needle cannula is located outside the reservoir and distally to the reservoir,and wherein, the predetermined volume of liquid confined in the reservoir of the telescopic needle covering shield is the identical same pharmaceutical preservative containing liquid drug as present in the interior chamber of the cartridge, such that the identical same pharmaceutical preservative containing liquid drug is present in both the reservoir of the telescopic needle covering shield and in the interior chamber of the cartridge, andwherein the injection device automatically ejects a predetermined amount of pharmaceutical preservative containing liquid drug into the reservoir upon first use of the injection device.

US Pat. No. 10,335,534

DIALYSIS PRESCRIPTION OPTIMIZATION FOR DECREASED ARRHYTHMIAS

Medtronic, Inc., Minneap...

1. A method, comprising:determining a potassium concentration of a patient;
determining a fluid volume of the patient;
calculating a desired potassium concentration change and a desired fluid volume change for a dialysis session, wherein the desired potassium concentration change and desired fluid volume change are calculated based on a first risk score for arrhythmia due to an anticipated change in potassium concentration and an anticipated change in fluid volume during dialysis; and
setting an ultrafiltration prescription and/or a potassium prescription based in part on the desired potassium concentration change and desired fluid volume change;
wherein the method uses a system comprising:
a dialysate flow loop comprising a dialyzer; wherein dialysate enters the dialyzer through a dialysate inlet and exits the dialyzer through a dialysate outlet;
an extracorporeal flow loop for transporting blood from the patient, to the dialyzer, and back to the patient;
an ultrafiltration pump, wherein the ultrafiltration pump controls a net fluid movement between the patient and the dialysate flow loop;
control electronics, wherein the control electronics are configured to control a pump rate of the ultrafiltration pump;
a processor; wherein the processor is configured to obtain the potassium concentration of the patient;
the processor configured to calculate the first risk score for arrhythmia, wherein the first risk score for arrhythmia is based at least in part on the potassium concentration of the patient and the fluid volume of the patient; and wherein the processor calculates the ultrafiltration prescription based on the first risk score for arrhythmia and transmits the ultrafiltration prescription to the control electronics; and
wherein the control electronics are configured to control the pump rate of the ultrafiltration pump based on the ultrafiltration prescription.

US Pat. No. 10,335,533

DEVICE FOR SEPARATING BLOOD INTO ITS COMPONENTS AS WELL AS A METHOD FOR DOING SO AND USE OF SUCH A DEVICE

FRESENIUS MEDICAL CARE DE...

1. A device for separating blood into its components, comprisinga magnetic bearing and drive device,
a container having a cylindrical shape suspended during operation in the bearing and drive device in a magnetically floating manner, having an axis, about which axis the container is rotated by the bearing and drive device during operation, and having at least one open end,
at least one tube-shaped inlet and at least one outlet provided, independently, in the at least one open end of the container,
at least one magnet connected to, or integrated into, the container, and
a control device configured to control the at least one magnet and the magnetic bearing and drive device for securing and accurately positioning the container in the bearing and drive device during operation.

US Pat. No. 10,335,532

DIALYSIS SYSTEM HAVING AUTOIDENTIFICATION MECHANISM

Baxter International Inc....

1. A dialysis system comprising:a dialysis instrument including at least one pump actuator;
a disposable cassette operable with the at least one pump actuator;
a plurality of disposable cassette supply connections;
a plurality of dialysis solution lines, each of the plurality of dialysis solution lines connected to a dialysis solution supply container and including a dialysis solution line connector;
an autoidentification mechanism configured to automatically identify information associated with each of the dialysis solution line connectors to determine each of (i) dialysis solution type, (ii) dialysis solution volume, and (iii) a number of the dialysis solution supply containers to supply the dialysis instrument for a treatment, the autoidentification mechanism further configured to automatically (a) image a geometry of each of the dialysis solution line connectors, and (b) compare the imaged geometry to a range of stored imaged geometries to determine
whether any of the dialysis solution line connectors is improperly positioned,
whether any of the dialysis solution line connectors is deformed, and
whether any of the dialysis solution line connectors is unmatched with respect to a particular therapy prescription; and
a controller configured to allow dialysis solution to be automatically drawn from the dialysis solution supply containers if the autoidentification mechanism confirms that correct dialysis solution supply containers are connected.

US Pat. No. 10,335,531

SYSTEM AND METHOD FOR CARDIOPULMONARY BYPASS USING HYPOBARIC OXYGENATION

1. A system for cardiopulmonary bypass, comprising:a cardiopulmonary bypass reservoir configured to store a blood;
a pump in fluid communication with the cardiopulmonary bypass reservoir configured to provide pressure to the system;
an oxygen source comprising a pressure regulator configured to regulate an oxygen pressure;
an oxygenator fluidly connected to the pressure regulator of the oxygen source via a sweep gas inlet, wherein the sweep gas inlet is configured to have a subatmospheric pressure and the oxygenator is configured to oxygenate the blood;
a vacuum regulator fluidly connected to the oxygenator via a sweep gas outlet, and configured to provide the subatmospheric pressure;
a vaporizer in fluid communication with the oxygenator;
a flow restrictor fluidly connected to the sweep gas inlet and configured to allow for a pressure drop from the oxygen source to the oxygenator, and disposed between the vaporizer and the oxygenator; and
an arterial filter fluidly connected to a blood outlet of the oxygenator and to the cardiopulmonary bypass reservoir.

US Pat. No. 10,335,530

LUNG ASSIST DEVICE WITH OSCILLATING FIBER BUNDLE

1. An extracorporeal system for lung assist comprising:a system housing, the system housing comprising a blood flow inlet and a blood flow outlet;
a fiber bundle housing movably positioned within the system housing, the fiber bundle housing comprising a gas inlet and a gas outlet;
a fiber bundle in operative connection with the fiber bundle housing, the fiber bundle comprising a plurality of hollow gas permeable fibers, wherein lumens of the plurality of hollow gas fibers are in fluid connection with the gas inlet at a first end thereof and in fluid connection with the gas outlet as a second end thereof;
an actuator to impart linear oscillatory motion to the fiber bundle housing and thereby to the fiber bundle.

US Pat. No. 10,335,529

EXTRA-CORPOREAL BLOOD TREATMENT DEVICE AND METHOD FOR SWITCHING OFF OR REDUCING THE SPEED OF A NON-OCCLUDING PUMP IN A FLUID SYSTEM OF AN EXTRA-CORPOREAL BLOOD DEVICE

Fresenius Medical Care De...

1. An extracorporeal blood treatment apparatus comprising:a fluid system comprising a blood feed line that leads to a blood treatment unit, and a blood discharge line that leads away from the blood treatment unit, wherein the blood treatment unit is divided into a blood chamber and a dialysis fluid chamber by means of a semi-permeable membrane,
a pump configured to (1) convey blood in the blood feed line or in the blood discharge line of the fluid system, or (2) convey dialysis fluid through the dialysis fluid chamber, wherein the pump is a non-occluding pump,
a first shut-off element for shutting off the blood feed line and a second shut-off element for shutting off the blood discharge line, and
a control unit for controlling the first shut-off element, the second shut-off element and the non-occluding pump,
wherein the control unit is configured such that before the speed of rotation of the pump is reduced or before the pump is shut off, the first shut-off element and the second shut-off element are closed, and the speed of rotation of the pump is reduced or the pump is shut off only after a predetermined time interval has lapsed, the predetermined time interval beginning after the first shut-off element and the second shut-off element are closed.

US Pat. No. 10,335,527

VENTRICULAR ASSIST ASSEMBLY, SYSTEM, AND METHOD

THE REGENTS OF THE UNIVER...

1. A method of attaching an implantable anastomotic assembly to cardiovascular tissue, the method comprising:engaging a connection interface against the cardiovascular tissue;
engaging an outer plate against the cardiovascular tissue a distance away from the connection interface; and
after engaging the connection interface and the outer plate against the cardiovascular tissue, interconnecting the connection interface to the outer plate using a connector;
wherein before interconnecting the connection interface and the outer plate, the connection interface is separate from and non-contiguous with the outer plate.

US Pat. No. 10,335,526

DETACHABLE PERCUTANEOUS CONNECTOR

HeartWare, Inc., Miami L...

1. A cover for a percutaneous connector extending through the skin of a patient comprising:an enclosure having an inner side and an outer side and defining a depression;
a first separable connector mounted to the enclosure and disposed entirely within the enclosure, the first separable connector being configured to detachably engage and electrically connect with the percutaneous connector, the enclosure being configured to isolate a distal end of the percutaneous connector from an exterior of the enclosure;
a second separable connector mounted to the enclosure and disposed within the depression, the second separable connector being electrically connected to the first separable connector, the second separable connector being exposed at the outer side of the enclosure and being configured to detachably engage and electrically connect with an external device, the second separable connector being spaced apart from the first connector by a cable; and
the inner side of the enclosure defining a skin-engaging surface at least partially surrounding the first separable connector and the percutaneous connector, when the first separable connector is engaged with the percutaneous connector.

US Pat. No. 10,335,525

BREASTSHIELD WITH MEDIA SEPARATION

MEDELA HOLDING AG, Baar ...

1. A breastshield unit for use in a device for expressing human breastmilk by means of underpressure applied to a nipple, wherein the device comprises an underpressure source for generating the underpressure applied to the nipple, wherein the breastshield unit comprises a breastshield body with a first opening for receiving the nipple of a mother's breast, with a second opening as a drain for expressed breastmilk and with at least one third opening for connection to the underpressure source in order to apply the underpressure to the nipple, wherein the breastshield unit further comprises a media separation membrane arranged in the breastshield body, the media separation membrane being made of a flexible material and transferring the underpressure generated by the underpressure source to the nipple and the media separation membrane separating the first opening and the second opening from the at least one third opening and therefore separating the expressed breastmilk from the underpressure source and therefore protecting the underpressure source from contamination by the expressed breastmilk, wherein the media separation membrane comprises a through-channel which connects the first opening of the breastshield body to the second opening of the breastshield body, the underpressure source disposed outside of the media separation membrane, wherein the through-channel comprises a through-opening, which is enlarged when subjected to the underpressure from the underpressure source, the through-opening being formed by walls of the media separation membrane, wherein the walls, when subjected to the underpressure, are moved away from each other in order to enlarge the through-opening from an initially closed or almost closed condition, mainly by purely geometric shifting of the position of the walls, the shifting of the position of the walls being caused by the underpressure generated by the underpressure source.

US Pat. No. 10,335,524

PORTABLE CHEST TUBE PRESSURE AND CO2 MONITOR

Mayo Foundation for Medic...

1. A chest tube thoracostomy system comprising:one or more sensors that are configured to detect a level of CO2 and a pressure of gas that is passing through a chest tube between a patient and a vacuum source; and
a monitoring device that is configured to be in electrical communication with the one or more sensors and that is configured to receive, from the one or more sensors, one or more signals that are indicative of the detected level of CO2 and the detected pressure of the gas that is passing through the chest tube between the patient and the vacuum source, the monitoring device comprising a user interface that is configured to display indications of the detected level of CO2 and the detected pressure,
wherein the monitoring device is configured to algorithmically process the one or more signals that are indicative of: (i) the detected level of CO2 and (ii) the detected pressure in combination with each other to enable determining whether the chest tube needs to be repositioned within the patient.

US Pat. No. 10,335,523

INCONTINENCE AID

1. A method of attaching an incontinence aid to a man, the method comprising:(a) positioning a pad body of the incontinence aid such that an interior side of the pad body adjacent a proximal end of the pad body is under the man's genitals;
(b) folding a first side edge of the pad body over at least a portion of the man's genitals such that the interior side of the pad body adjacent the proximal end of the pad body and adjacent the first side edge of the pad body faces at least a portion of the man's genitals;
(c) folding a second side edge of the pad body over the first side edge of the pad body such that the interior side of the pad body adjacent the proximal end of the pad body and adjacent the second side edge of the pad body faces at least a portion of an exterior side of the pad body adjacent the proximal end of the pad body and adjacent the first side edge of the pad body;
(d) folding the pad body such that the interior side of the pad body adjacent a distal end of the pad body faces at least a portion of the exterior side of the pad body to cover the man's genitals; and
(e) securing the pad body in a folded position to retain the pad body on the man's genitals.

US Pat. No. 10,335,522

INTERFACES, SYSTEMS, AND METHODS FOR USE IN REDUCED PRESSURE TISSUE TREATMENT

KCI Licensing, Inc., San...

1. A system for treating a tissue site with a reduced pressure, comprising:a manifold for placing proximate the tissue site, the manifold having a first side and a second side, the second side of the manifold adapted to face the tissue site;
a flexible film drape for covering the first side of the manifold to form a sealed space containing the manifold, the flexible film drape having an aperture adapted to provide fluid communication with the sealed space;
an interface for positioning over the flexible film drape proximate the aperture, the interface having a first side and a second side, the second side of the interface adapted to face the tissue site, the interface comprising:
an inlet port positioned proximate the first side of the interface and adapted to intake ambient gas, the inlet port comprising a constricted portion having a first diameter at an upstream end and a second diameter at an opposing downstream end, wherein the second diameter is smaller than the first diameter, and wherein the constricted portion is adapted to provide a pressure drop,
a first reduced-pressure channel extending through the interface from the inlet port to an outlet port positioned proximate the first side of the interface,
a second reduced-pressure channel adapted to deliver the reduced pressure to the tissue site, the second reduced-pressure channel fluidly coupled between the first reduced-pressure channel and the second side of the interface, wherein the reduced pressure substantially corresponds to the pressure drop, and
a pressure-sensing port positioned in the second side of the interface;
a reduced-pressure source fluidly coupled to the outlet port; and
a pressure-sensing unit fluidly coupled to the pressure-sensing port for monitoring pressure proximate the tissue site.

US Pat. No. 10,335,521

REDUCED PRESSURE THERAPY DEVICES

The Board of Trustees of ...

1. A reduced pressure therapy system, the system comprising:a wound dressing comprising:
a sealing film comprising an adhesive region, wherein the sealing film is configured to be affixed around an area of tissue to be treated and create a sealed enclosure,
an outlet port, and
a contact layer comprising a plurality of stacked sheets retained by a porous layer;
a suction apparatus configured to generate reduced pressure of at least ?50 mm Hg, the suction apparatus comprising:
a first chamber having a distal end and a proximal end, wherein the first chamber has rigid sides having first threads from the distal end to the proximal end of the first chamber on an internal surface,
a reciprocating member comprising second threads on an outer surface configured to engage the first threads to form a threaded interface allowing the reciprocating member to sealably rotate along the rigid sides,
a second chamber, and
a valve controlling fluid communication with the second chamber; and
an extension tube configured to attach to the outlet port of the wound dressing and to the suction apparatus.

US Pat. No. 10,335,518

CATHETER LOCKING FORMULATION AND METHOD TO PREPARE SAME

1. A method to prepare a catheter locking formulation, comprising the following steps in the following order:dissolving trimethoprim in propylene glycol at a temperature between about 50° C. and about 55° C. with stirring for at least 60 minutes to form a solution of trimethoprim and propylene glycol;
sequentially adding at a temperature between about 50° C. and about 55° C., in the following order, phosphate buffered saline, EDTA Calcium Disodium Hydrate, and glycerin, to said trimethoprim/propylene glycol solution, wherein glycerin should be added only after all solids have been completely solubilized;
cooling said propylene glycol solution containing trimethoprim, propylene glycol, phosphate buffered saline, EDTA Calcium Disodium Hydrate, and glycerin to about room temperature;
adding absolute ethanol at about room temperature to a room temperature solution of trimethoprim, propylene glycol, EDTA Calcium Disodium Hydrate, phosphate buffered saline, and glycerin to form a catheter locking solution;
wherein said absolute alcohol is present at a level of at least fifteen (15) weight percent of said catheter locking solution;
wherein said catheter locking solution maintains shelf life stability, including no formation of precipitates, at temperatures between 0° C. to about 42° C. for at least three days; and
wherein said catheter locking solution comprises a pH between about 8 and about 9.

US Pat. No. 10,335,513

HYDROPHILIZATION AND ANTIFOULING OF ENHANCED METAL SURFACES

Cardiac Pacemakers, Inc.,...

1. A method for coating a roughened titanium surface of an implantable medical device, the method comprising:providing a material with a roughened titanium metal surface;
activating at least a portion of the roughened titanium surface with an oxygen containing plasma, wherein the activating step forms hydroxyl groups on the titanium surface; and
treating the activated roughened titanium surface with a poly(ethylene glycol) to covalently bond the poly(ethylene glycol) directly to a titanium atom of the roughened titanium surface by an inorganic ether bond.

US Pat. No. 10,335,510

METHOD AND DEVICE FOR FEMALE URINARY INCONTINENCE

ParaPatch, Inc., Campbel...

1. A patch for treating female urinary incontinence, the patch sized and configured to fit directly on and cover a clitoris without covering a urethra, the patch configured when applied to stimulate the clitoris to inhibit discharge from a bladder.

US Pat. No. 10,335,506

MOBILE ULTRAVIOLET LAMP APPARATUSES HAVING A REFLECTOR SYSTEM THAT REDIRECTS LIGHT TO A HIGH TOUCH AREA OF A ROOM

Xenex Disinfection Servic...

1. An apparatus, comprising:a germicidal lamp configured to emit ultraviolet light, wherein the germicidal lamp is arranged lengthwise substantially parallel to a horizontal plane of the apparatus;
a mobile carriage supporting the germicidal lamp, wherein the mobile carriage comprises:
one or more compartments underneath said arranged germicidal lamp, wherein the one or more compartments hold operational components for the apparatus;
a casing enclosing the one or more compartments, wherein the apparatus is configured such that the germicidal lamp is not moveable beyond vertical planes aligned with the casing when the germicidal lamp is supported by the mobile carriage; and
wheels along a bottom of the mobile carriage to affect portability of the apparatus; and
a reflector system arranged in the apparatus such that ultraviolet light emitted from the germicidal lamp is projected to a region exterior to the apparatus between approximately 2 feet and approximately 4 feet from a floor of a room in which the apparatus is arranged, wherein the apparatus is configured such that a reflector of the reflector system is moveable relative to the mobile carriage.

US Pat. No. 10,335,504

HETEROCYCLIC MOLECULES FOR BIOMEDICAL IMAGING AND THERAPEUTIC APPLICATIONS

Washington University, S...

1. A compound or a pharmaceutically acceptable salt thereof selected from the group consisting ofor a pharmaceutically acceptable salt thereof.

US Pat. No. 10,335,503

COMPOUND THAT SPECIFICALLY BINDS TO AMPA RECEPTOR

Public University Corpora...

1. A compound of Formula (I), or a pharmaceutically acceptable salt thereof or solvate thereof:
wherein:
each of A and Z independently is CO, SO, or SO2;
each of X and Y independently is S or O;
each of R1, R3, and R4 independently is hydrogen, alkyl, alkenyl, alkynyl, or halo;
R2 is alkyl, alkenyl, or alkynyl;
each R5 independently is alkyl, alkenyl, alkynyl, or halo; and
n is an integer of 0 to 4.

US Pat. No. 10,335,497

PYRROLOBENZODIAZEPINES AND CONJUGATES THEREOF

MEDIMMUNE LIMITED, Cambr...

1. A method of synthesising compound B:
from:

via the intermediate:
which comprises the steps of:(i) removing the Alloc
protecting groups; and(ii) reacting the product of (i) with Mal-(PEG)8-acid.

US Pat. No. 10,335,495

BIOMOLECULE CONJUGATES

CELGENE CORPORATION, Sum...

1. A compound of Formula I
wherein
A is dibenzocyclooctynyl, cyclooct-4-ynoxyl, or (1R,8S,9S)-bicyclo[6.1.0]non-4-yn-9-ylmethyloxy;
D is a maytansinoid;
m is 1;
E is

wherein:
J is an amino acid or peptide;
h is an integer from 0 to 30;
d, e, g, j, and k are each independently an integer from 1 to 30;
each R4 is independently H, alkyl, —N(R3)2, —SR3, and C1-C8 alkoxy, aryl;
each of R3 or R3? is H, C1-C8 alkyl; and
“d is 5” and “R3? is H” are not satisfied simultaneously.

US Pat. No. 10,335,491

CATALYTIC DELIVERY NANOSUBSTRATES (CDNS) FOR HIGHLY EFFICIENT DELIVERY OF BIOMOLECULES

The Regents of the Univer...

1. A molecular delivery system, comprising:a substrate having
a nanostructured surface region which comprises a plurality of nanostructures and, covalently attached to the nanostructured surface region, multiple copies of a first member of a binding pair; and
at least one vector nanoparticle which comprises
encapsulated therein, a molecule of interest, and,
on its surface, multiple copies of a second member of the binding pair,
wherein the plurality of nanostructures are nanofibers or nanowires made of silicon, titanium, aluminum, steel, or an organic oxide, or are organic polymers comprising at least one of polymethacrlate, polysaccharide or polylactide,
wherein the plurality of nanostructures comprise a length and diameter such that the length is greater than the diameter,
wherein the plurality of nanostructures are attached at a first end to the substrate, and
wherein the first member of the binding pair is covalently attached to an outer surface region of the plurality of nanostructures such that the at least one vector nanoparticle is attached to the outer surface region of the plurality of nanostructures when the second member of the binding pair and the first member of the binding pair are engaged, and
wherein each vector nanoparticle further comprises:
a plurality of structural components that are suitable to at least provide some mechanical structure to said vector nanoparticle;
a plurality of binding components, each having a plurality of binding regions adapted to bind to said plurality of structural components; and
a plurality of terminating components, each of which is adapted to bind to a binding region of one of said plurality of binding components,
wherein said plurality of structural components and said plurality of binding components self-assemble when brought into contact to form said vector nanoparticle,
wherein said plurality of terminating components act to occupy binding regions of said plurality of binding components to terminate further binding when said plurality of terminating components are present in a sufficient quantity relative to said plurality of binding regions of said plurality of binding components,
wherein the plurality of binding regions comprise ?-cyclodextrin,
wherein each of said plurality of structural components comprises at least one binding element adapted to bind to the binding regions to form a first inclusion complex,
wherein the binding element comprises adamantine,
wherein the first inclusion complex is adamantine-?-cyclodextrin,
wherein each of the plurality of terminating components comprise a single terminating binding element that binds to remaining binding regions of one of said plurality of binding components by forming a second inclusion complex,
wherein said terminating binding element comprises adamantine, and
wherein said second inclusion complex is adamantine-?-cyclodextrin.

US Pat. No. 10,335,490

FLUORINATED POLYMERIZABLE HYDROGELS FOR WOUND DRESSINGS AND METHODS OF MAKING SAME

The University of Akron, ...

1. A hydrogel comprising:crosslinked polymers, the polymers having polysaccharide backbone chains, wherein the polysaccharide backbone chains have a pendant fluorine group attached thereto; and
wherein the polysaccharide backbone chains include one or more saccharide units that include an alkene group selected from the group consisting of:

US Pat. No. 10,335,489

INJECTABLE SOLUTION AT PH 7 COMPRISING AT LEAST ONE BASAL INSULIN THE PI OF WHICH IS BETWEEN 5.8 AND 8.5 AND A SUBSTITUTED CO-POLYAMINO ACID

ADOCIA, Lyons (FR)

1. A composition in the form of an injectable aqueous solution, the pH of which is between 6.0 and 8.0, comprising at least:a) a basal insulin, the isoelectric point pI of which is between 5.8 and 8.5;
b) a prandial insulin,
c) a co-polyamino acid bearing carboxylate charges and substituted with hydrophobic groups, chosen from the co-polyamino acids of formula I:

 in which:
A independently represents either a —CH2— group (aspartic unit) or a —CH2—CH2— group (glutamic unit),
R1 is a radical chosen from the group consisting of an H, a linear C2 to C10 acyl group, a branched C3 to C10 acyl group, a benzyl, a terminal “amino acid” unit and a pyroglutamate,
R2 is an —NR?R? radical, R? and R?, which may be identical or different, being chosen from the group consisting of H, linear or branched or cyclic C2 to C30 alkyls and benzyl, and said R? and R? alkyls being alkyls which can together form one or more saturated, unsaturated and/or aromatic rings which are carbon-based and/or which can comprise heteroatoms, chosen from the group consisting of O, N and S,
R?3 is a radical chosen from the group consisting of the radicals of formulae —OR3, II or II?:

 in which * indicates the site of attachment to the co-polyamino acid
R3 and R?3, which may be identical or different, represent an H or a cationic entity chosen from the group comprising metal cations,
—R is a hydrophobic radical chosen from the group consisting of a saturated or unsaturated, linear or branched C8 to C30 radical which can comprise heteroatoms or a C8 to C30 radical which can form rings which are carbon-based or which can comprise heteroatoms, which are saturated, unsaturated and/or aromatic, said rings possibly being ortho-condensed or peri-condensed, or a radical of formula III or III? as defined below:

 in which * indicates the site of attachment to the co-polyamino acid, and
R4 and R?4, which may be identical or different, represent an H, a cationic entity chosen from the group comprising metal cations, an R?4 radical or an R??4 radical, and at least one of R4 and R?4 is equal to R?4,
R?4 represents a saturated or unsaturated, linear or branched C8 to C30 radical which can comprise heteroatoms or a C8 to C30 radical which can form rings which are carbon-based or which can comprise heteroatoms, which are saturated, unsaturated and/or aromatic, said rings possibly being ortho-condensed or peri-condensed,
R??4 represents a saturated or unsaturated, linear or branched C1 to C7 radical which can comprise heteroatoms or a C1 to C7 radical which can form rings which are carbon-based or which can comprise heteroatoms, which are saturated, unsaturated and/or aromatic, said rings possibly being ortho-condensed or peri-condensed, and
B independently represents either a —CH2— group (aspartic unit) or a —CH2—CH2— group (glutamic unit),
R5 is a radical chosen from the group consisting of an H, a linear or branched C1 to C4 alkyl or a benzyl group,
n/(n+m) is defined as the molar degree of grafting with hydrophobic radical of the monomeric units and is between 1 and 50 mol %,
n+m represents the degree of polymerization of the co-polyamino acid, i.e. the average number of monomeric units per chain of co-polyamino acid, and 5 ?n+m?1000.

US Pat. No. 10,335,477

COMPOSITIONS AND METHODS FOR DIAGNOSING, PREVENTING AND TREATING SALMONELLA TYPHI AND SALMONELLA PARATYPHI INFECTION

YALE UNIVERSITY, New Hav...

1. An immunological composition comprisinga.) a mutant Pertussin-like toxin A (PltA) polypeptide comprising the mutation E133A within SEQ ID NO: 8,
b.) a mutant Cytolethal distending toxin B (CdtB) polypeptide comprising the mutation H160Q within SEQ ID NO: 7 and
c.) a Pertussin-like toxin B (PltB) polypeptide.

US Pat. No. 10,335,432

MICROPOROUS ZIRCONIUM SILICATE FOR THE TREATMENT OF HYPERKALEMIA

ZS PHARMA, INC., Coppell...

1. A method of treating hyperkalemia in a subject in need thereof comprising administering between 3 and 9 g per day of particles with a uniform microporous structure, a pore diameter of about 3 angstroms, and a median particle size greater than 3 microns, the particles being capable of binding potassium with a potassium exchange capacity (KEC) of at least 1.7 mEq/g, wherein less than 7% of the administered particles are under 3 microns.

US Pat. No. 10,335,426

N-ACETYL MANNOSAMMINE AS A THERAPEUTIC AGENT

THE UNITED STATES OF AMER...

1. A method of treating a condition or disease in a mammal in need thereof comprising selecting a subject with the condition or disease, and administering to the subject an effective amount of N-acetyl mannosamine or a derivative thereof, to the mammal, wherein the derivative consists of Formula I.wherein R1, R3, R4, or R5 is hydrogen, lower alkanoyl, carboxylate or lower alkyl; R2 is lower alkyl, lower alkanoylalkyl, lower alkyl alkanoyloxy; and the condition or disease is diabetic nephropathy.

US Pat. No. 10,335,425

COMPOSITIONS AND METHODS OF TREATING OF BACTERIAL INFECTIONS WITH ?-LACTAMASE INHIBITORS

CASE WESTERN RESERVE UNIV...

1. A pharmaceutical composition comprising a therapeutically effective amounts of at least one ?-lactam antibiotic and at least one triazolylmethyl boronic acid, wherein the triazolylmethyl boronic acid is selected from the group consisting of:
wherein R1?CH2NHC(?O)-phenyl or benzyl, CH2NHS(?O)2-phenyl or alkyl substituted phenyl, —COOH, ester, aryl, heteroaryl, or —CH2Oaryl;
R3=benzyl, alkyl, H or —CH2-benzoic acid;
R4±S(?O)2-phenyl or alkyl substituted phenyl, C(?O)-phenyl or benzyl, C(?O)NH-phenyl;
R5=—COOH or H; and pharmaceutically acceptable salts thereof.

US Pat. No. 10,335,423

INHIBITION OF HIV INFECTION THROUGH CHEMOPROPHYLAXIS

THE UNITED STATES OF AMER...

1. A process of protecting a primate host from a self-replicating infection by an immunodeficiency retrovirus comprising:(a) selecting a primate host not infected with the immunodeficiency retrovirus, and
(b) administering directly to the primate host a combination comprising:
i. a pharmaceutically effective amount of emtricitabine; and
ii. a pharmaceutically effective amount of tenofovir or a tenofovir prodrug,
wherein the combination is administered orally prior to the exposure of the primate host to the immunodeficiency retrovirus,
thereby protecting the primate host from infection with the immunodeficiency retrovirus.

US Pat. No. 10,335,420

NANOPARTICLE-BASED TUMOR-TARGETED DRUG DELIVERY

The Scripps Research Inst...

1. An aqueous tumor-targeting liposome nanoparticle composition comprising an aqueous dispersion of liposome nanoparticles; the liposome nanoparticles comprising a legumain-targeting lipid component and a polyethylene glycol-conjugated lipid component; the legumain-targeting lipid component comprising a hydrophobic lipid portion covalently attached to a legumain-binding moiety, wherein the legumain-targeting lipid component comprises a compound of the Formula:

US Pat. No. 10,335,419

SLOW RELEASE OXYSTEROLS AND METHODS OF USE

Warsaw Orthopedic, Inc, ...

1. A method of treating a bone defect site, the method comprising: implanting an implant at the bone defect site, the implant comprising a slow release composition to promote bone growth, the slow release composition comprising: an oxysterol comprising (3S,5S,6S,8R,9S,10R,13S,14S,17S)17-((S)-2-hydroxyoctan-2-yl)-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthrene-3,6-diol (Oxy133) monohydrate encapsulated in a biodegradable polymer to control the release of the oxysterol, wherein the biodegradable polymer is in the form of microspheres disposed within a biodegradable matrix, the oxysterol is in an amount of about 5 wt % of the biodegradable matrix, the biodegradable matrix further comprising mineral particles in an amount of about 80 wt % of the biodegradable matrix, and the mineral particles comprise tricalcium phosphate and hydroxyapatite in a ratio of about 85:15, wherein the composition comprises carboxymethyl cellulose (CMC) in an amount of about 4 wt % of the composition, and the biodegradable matrix comprises collagen in an amount of about 12 wt % of the biodegradable matrix, wherein the collagen comprises insoluble and soluble collagen in a weight ratio of about 75:25 to about 65:35.

US Pat. No. 10,335,418

METHODS AND COMPOSITIONS FOR TREATING METABOLIC SYNDROME

Topokine Therapeutics, In...

1. A method for reducing body fat in an individual, the method comprising administering systemically to the skin of the individual a pharmaceutical composition comprising a compound of formula:
or a pharmaceutically acceptable salt thereof,
wherein the individual suffers from an excess of body fat.

US Pat. No. 10,335,417

THIAZIDEAMIDE DERIVATIVE AND USE THEREOF

Institute of Pharmacology...

1. A compound, or a pharmaceutically acceptable salt or solvate thereof, wherein the compound is selected from:

US Pat. No. 10,335,415

(ALPHA-SUBSTITUTED ARALKYLAMINO AND HETEROARYLALKYLAMINO) PYRIMIDINYL AND 1,3,5-TRIAZINYL BENZIMIDAZOLES, PHARMACEUTICAL COMPOSITIONS THEREOF, AND THEIR USE IN TREATING PROLIFERATIVE DISEASES

MEI PHARMA, INC., San Di...

1. A compound of Formula II:
or an enantiomer, a mixture of enantiomers, a mixture of two or more diastereomers, or an isotopic variant thereof; or a pharmaceutically acceptable salt, solvate or hydrate thereof; wherein:X, Y, and Z are each independently N;R1 and R2 are each independently (a) hydrogen, cyano, halo, or nitro;(b) C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 cycloalkyl, C6-14 aryl, C7-15 aralkyl, heteroaryl, or heterocyclyl; or (c) —C(O)R1a, —C(O)OR1a, —C(O)NR1bR1c, —C(NR1a)NR1bR1c, —OR1a, —OC(O)R1a, —OC(O)OR1a, —OC(O)NR1bR1c, —OC(?NR1a)NR1bR1c, —OS(O)R1a, —OS(O)2R1a, —OS(O)NR1bR1c, —OS(O)2NR1bR1c, —NR1bR1c, —NR1aC(O)R1d, —NR1aC(O)OR1d, —NR1aC(O)NR1bR1c, —NR1aC(?NR1d)NR1bR1c, —NR1aS(O)R1d, —NR1aS(O)2R1d, —NR1aS(O)NR1bR1c, —NR1aS(O)2R1bR1c, —SR1a, —S(O)R1a, —S(O)2R1a, —S(O)NR1bR1c, or —S(O)2NR1bR1c; wherein each R1a, R1b, R1c, and R1d is independently (i) hydrogen;
(ii) C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 cycloalkyl, C6-14 aryl, C7-15 aralkyl, heteroaryl, or heterocyclyl; or (iii) R1b and R1c together with the N atom to which they are attached form heterocyclyl;R3 and R4 are each independently hydrogen or C1-6 alkyl; or R3 and R4 are linked together to form a bond, C1-6 alkylene, C1-6 heteroalkylene, C2-6 alkenylene, orC2-6 heteroalkenylene;R5a is hydrogen or C1-6 alkyl;R5b is C1-6 alkyl or —C(O)OR1a;R5c is —(CR5fR5g)n—(C6-14 aryl);R5f and R5g are each independently (a) hydrogen or halo; (b) C1-6 alkyl,C2-6 alkenyl, C2-6 alkynyl, C3-10 cycloalkyl, C6-14 aryl, C7-15 aralkyl, heteroaryl, or heterocyclyl; or (c) —C(O)R1a, —C(O)OR1a, —C(O)NR1bR1c, —C(NR1a)NR1bR1c, —OR1a, —OC(O)R1a, —OC(O)OR1a, —OC(O)NR1bR1c, —OC(?NR1a)NR1bR1c, —OS(O)R1a, —OS(O)2R1a, —OS(O)NR1bR1c, —OS(O)2NR1bR1c, —NR1bR1c, —NR1aC(O)R1d, —NR1aC(O)OR1d, —NR1aC(O)NR1bR1c, —NR1aC(?NR1d)NR1bR1c, —NR1aS(O)R1d, —NR1aS(O)2R1d, —NR1aS(O)NR1bR1c, —NR1aS(O)2NR1bR1c, —SR1a, —S(O)R1a, —S(O)2R1a, —S(O)NR1bR1c; or —S(O)2NR1bR1c; or (d) when one occurrence of R5f and one occurrence of R5g are attached to the same carbon atom, the R5f and R5g together with the carbon atom to which they are attached form a C3-10 cycloalkyl or heterocyclyl;R6 is C1-6 alkyl; andn is 0 or 1;wherein each alkyl, alkylene, heteroalkylene, alkenyl, alkenylene, heteroalkenylene, alkynyl, cycloalkyl, aryl, aralkyl, heteroaryl, and heterocyclyl in R1, R2, R3, R4, R6, R1a, R1b, R1c, R1d, R5a, R5b, R5c, R5f, and R5g is optionally substituted with one, two, three, four, or five substituents Q, wherein each substituent Q is independently selected from (a) oxo, cyano, halo, and nitro; (b) C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 cycloalkyl, C6-14 aryl, C7-15 aralkyl, heteroaryl, and heterocyclyl, each of which is further optionally substituted with one, two, three, or four substituents Qa; and (c) —C(O)Ra, —C(O)ORa,—C(O)NRbRc, —C(NRa)NRbRc, —ORa, —OC(O)Ra, —OC(O)ORa, —OC(O)NRbRc, —OC(?NRbRc, —OS(O)Ra, —OS(O)2Ra, —OS(O)NRbRc, —OS(O)2NRbRc, —NRbRc, —NRaC(O)Rd, —NRaC(O)ORd, —NRaC(O)NRbRc, —NRaC(?NRd)NRbRc, —NRaS(O)Rd, —NRaS(O)2Rd, —NRaS(O)NRbRc, —NRaS(O)2NRbRc, —SRa, —S(O)Ra, —S(O)2Ra, —S(O)NRbRc, and —S(O)2NRbRc, wherein each Ra, Rb, Rc, and Rd is independently (i) hydrogen;
(ii) C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 cycloalkyl, C6-14 aryl, C7-15 aralkyl, heteroaryl, or heterocyclyl, each of which is further optionally substituted with one, two, three, or four substituents Qa; or (iii) Rb and Rc together with the N atom to which they are attached form heterocyclyl, which is further optionally substituted with one, two, three, or four substituents Qa; andwherein each Qa is independently selected from the group consisting of (a) oxo, cyano, halo, and nitro; (b) C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 cycloalkyl, C6-14 aryl, C7-15 aralkyl, heteroaryl, and heterocyclyl; and (c) —C(O)Re, —C(O)ORe, —C(O)NRfRg, —C(NRe)NRfRg, —ORe, —OC(O)Re, —OC(O)ORe, —OC(O)NRfRg, —OC(?NRe)NRfRg, —OS(O)Re, —OS(O)2Re, —OS(O)NRfRg, —OS(O)2NRfRg, —NRfRg, —NReC(O)Rh, —NReC(O)ORh, —NReC(O)NRfRg, —NReC(?NRh)NRfRg, —NReS(O)Rh, —NReS(O)2Rh, —NReS(O)NRfRg, —NReS(O)2NRfRg, —SRe, —S(O)Re, —S(O)2Re, —S(O)NRfRg, and —S(O)2NRfRg; wherein each Re, Rf, Rg, and Rh is independently (i) hydrogen; (ii) C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 cycloalkyl, C6-14 aryl, C7-15 aralkyl, heteroaryl, or heterocyclyl; or (iii) Rf and Rg together with the N atom to which they are attached form heterocyclyl.

US Pat. No. 10,335,413

SUBSTITUTED XANTHINE DERIVATIVES

Concert Pharmaceuticals, ...

1. A method of treating a disease or condition in a patient in need thereof, comprising administering to the patient an effective amount of a compound represented by the following structural formula:
or a pharmaceutically acceptable salt thereof, wherein R1 is selected from —CH3 and —CD3;
R2 is selected from —CH3 and —CD3; Y1 is deuterium or hydrogen, wherein the isotopic enrichment factor for each designated deuterium atom is at least 5000, wherein the disease is selected from insulin dependent diabetes, non-insulin dependent diabetes, metabolic syndrome, obesity, insulin resistance, dyslipidemia, pathological glucose tolerance, hypertension, hyperlipidemia, hyperuricemia, gout, and hypercoagulability.

US Pat. No. 10,335,410

HETEROARYL COMPOUNDS USEFUL AS INHIBITORS OF SUMO ACTIVATING ENZYME

Millennium Pharmaceutical...

1. A method of treating lung cancer, ovarian cancer, colon cancer, breast cancer, or lymphoma in a subject, comprising administering to a subject having lung cancer, ovarian cancer, colon cancer, breast cancer, or lymphoma a therapeutically effective amount of a chemical entity which is a compound or pharmaceutically acceptable salt of formula (I):
wherein:
stereochemical configurations depicted at asterisked positions indicate absolute stereochemistry;
Y is —O—, —CH2—, or —N(H)—;
Ra is hydrogen, fluoro, —NH2, or hydroxyl;
Ra? is hydrogen or fluoro, provided that when Ra is —NH2 or hydroxyl, Ra? is hydrogen;
Rb is hydrogen or, together with the oxygen to which it is attached, forms a prodrug;
Rc is hydrogen or C1-4 alkyl;
Rd is hydrogen, halogen, —CF3, or C1-4 alkyl;
X1 is N;
X2 is S or O;
X3 is C(Rx3) or N;
Rx3 is hydrogen, methyl, or halogen;
Z1 is hydrogen, halogen, cyano, Rz3, —S—Rz3, —S(O)—Rz3, or —S(O)2—Rz3;
Rz3 is an optionally substituted phenyl, an optionally substituted 5- to 7-membered cycloaliphatic, an optionally substituted 5- to 7-membered heterocyclyl, or an optionally substituted C1-4 aliphatic;
wherein Z1 is not hydrogen, halogen, methyl, or cyano if Z2 is hydrogen or methyl; and
(a) Z2 is a ring system having an optionally substituted 5- to 7-membered heterocyclyl with 1-2 heteroatoms or an optionally substituted 5- to 7-membered cycloaliphatic fused to
(i) an optionally substituted 5-membered heteroaryl or an optionally substituted 6-membered aryl or heteroaryl to form a bicyclic group; or
(ii) an optionally substituted 9-membered heteroaryl or an optionally substituted 10-membered aryl or heteroaryl to form a tricyclic group;
or
(b) Z2 is L-Re wherein L is L1-, —V1-L2-, or L1-V1-L2-;
L1 is a C1-3 alkylene chain wherein 1 or 2 saturated carbon atoms are optionally substituted by (Rf)(Rf?) and in which there are optionally one or two degrees of unsaturation;
each Rf is independently hydrogen; hydroxyl; —N(Rh)(Rh?); C1-4 aliphatic optionally substituted with hydroxyl, —OCH3, or cyclopropyl; —O—C1-4 aliphatic optionally substituted with hydroxyl, —OCH3, or cyclopropyl; or, together with Rf? and the carbon atom to which they are attached, form C?CH2, or a 3- to 6-membered carbocycle or 4- to 6-membered heterocycle comprising a heteroatom chosen from N (which may be protonated or C1-4 alkylated), O, or S, the heteroatom optionally located immediately adjacent to the quaternary carbon of the heterocycle;
each Rf? is independently hydrogen; C1-4 aliphatic optionally substituted with hydroxyl, —OCH3, or cyclopropyl; —O—C1-4 aliphatic optionally substituted with hydroxyl, —OCH3, or cyclopropyl; or, together with Rf and the carbon atom to which they are attached, form C?CH2, or a 3- to 6-membered carbocycle or 4- to 6-membered heterocycle comprising a heteroatom chosen from N (which may be protonated or C1-4 alkylated), O, or S, the heteroatom optionally located immediately adjacent to the quaternary carbon of the heterocycle; wherein if Rf is hydroxyl, Rf? is not —O—C1-4 aliphatic optionally substituted with hydroxyl, —OCH3, or cyclopropyl;
Rh and Rh? are each independently hydrogen or C1-4 alkyl;
V1 is —S—, —O—, —S(O)—, —S(O)2—, —C(O)— or —N(Rg)—;
L2 is a C0-2 alkylene chain wherein one saturated carbon atom is optionally substituted by (Rf)(Rf?);
Rg is hydrogen or C1-4 alkyl; and
either (i) Re is hydrogen, hydroxyl, halogen, —CF3, or an optionally substituted C1-4 aliphatic,
with the proviso that Re is not hydrogen if Rf and Rf? are present and form a ring; or
(ii) Re is a ring chosen from optionally substituted 6-membered aryl, optionally substituted 5-to 6-membered heteroaryl, optionally substituted 3- to 7-membered cycloaliphatic, or optionally substituted 4- to 7-membered heterocyclyl, which is optionally fused to a second optionally substituted 6-membered aryl, optionally substituted 5-to 6-membered heteroaryl, optionally substituted 3- to 7-membered cycloaliphatic, or optionally substituted 4- to 7-membered heterocyclyl;
or
(c) Z2 is hydrogen.

US Pat. No. 10,335,409

INHIBITORS OF HEPATITIS C VIRUS

Gilead Pharmasset LLC, F...

1. A compound of formula:

US Pat. No. 10,335,406

OPIOID COMPOSITIONS RESISTANT TO OVERDOSE AND ABUSE

Elysium Therapeutics, Inc...

1. A composition comprising a macromolecule of Formula (I):
and a therapeutically-effective amount of a macromolecule of Formula (II):

or pharmaceutically acceptable salts thereof, wherein:
PD is a gastrointestinal enzyme-labile opioid agonist prodrug and the gastrointestinal enzyme-labile opioid agonist prodrug is:

wherein:
Y is H or OH;
AA is a natural or unnatural amino acid side chain that is recognized by the gastrointestinal enzyme; and
R is independently hydrogen, methyl, ethyl, substituted alkyl, acyl, a natural or unnatural amino acid, or a polypeptide comprising up to 10 natural and/or unnatural amino acids;
I is a gastrointestinal enzyme inhibitor and the gastrointestinal enzyme inhibitor is:

X2 is independently at each occurrence absent or
that joins I to a polymer P2 wherein: k and m are independently at each occurrence an integer from 0 to 10;X1 is independently at each occurrence absent or an ether, an ester, a thioester, an amide, an amine, a carbamate, a carbonate, a thioether, or a urea, wherein the nitrogen atom of the amide, amine, or carbamate, is substituted or unsubstituted and the nitrogen atoms of the urea are each independently substituted or unsubstituted, that joins PD to a polymer P1;
each P1 and P2 is independently a polyalkylene glycol; and
n is independently an integer from 1 to 2.

US Pat. No. 10,335,401

NON-AROMATIC HETEROCYCLIC DERIVATIVE HAVING MGAT2 INHIBITORY ACTIVITY

1. A compound represented by Formula (I):whereinX is C(?O), C(?S), or SO2;
Z is C(?O), C(?S), C(?N—RN), or SO2;
L is a single bond, —O—, —S—, or —NRN—;
R is R6 or a group represented by the following formula:

A is aromatic carbocycle, non-aromatic carbocycle, aromatic heterocycle, or non-aromatic heterocycle;
B is aromatic carbocycle, non-aromatic carbocycle, aromatic heterocycle, or non-aromatic heterocycle;
R2 is hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkylcarbonyl, substituted or unsubstituted alkyloxycarbonyl, substituted or unsubstituted alkylsulfonyl, substituted or unsubstituted aromatic carbocyclyl, substituted or unsubstituted non-aromatic carbocyclyl, substituted or unsubstituted aromatic heterocyclyl, substituted or unsubstituted non-aromatic heterocyclyl, substituted or unsubstituted aromatic carbocyclylcarbonyl, substituted or unsubstituted non-aromatic carbocyclylcarbonyl, substituted or unsubstituted aromatic heterocyclylcarbonyl, substituted or unsubstituted non-aromatic heterocyclylcarbonyl, substituted or unsubstituted aromatic carbocyclyloxycarbonyl, substituted or unsubstituted non-aromatic carbocyclyloxycarbonyl, substituted or unsubstituted aromatic heterocyclyloxycarbonyl, substituted or unsubstituted non-aromatic heterocyclyloxycarbonyl, substituted or unsubstituted aromatic carbocyclylsulfonyl, substituted or unsubstituted non-aromatic carbocyclylsulfonyl, substituted or unsubstituted aromatic heterocyclylsulfonyl, or substituted or unsubstituted non-aromatic heterocyclylsulfonyl;
R3 is hydrogen, cyano, substituted or unsubstituted carbamoyl, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted alkylsulfonyl, substituted or unsubstituted aromatic carbocyclyl, substituted or unsubstituted non-aromatic carbocyclyl, substituted or unsubstituted aromatic heterocyclyl, substituted or unsubstituted non-aromatic heterocyclyl, substituted or unsubstituted aromatic carbocyclylsulfonyl, substituted or unsubstituted non-aromatic carbocyclylsulfonyl, substituted or unsubstituted aromatic heterocyclylsulfonyl, or substituted or unsubstituted non-aromatic heterocyclylsulfonyl;
R4a and R4b are each independently hydrogen, halogen, hydroxy, cyano, substituted or unsubstituted alkyl, substituted or unsubstituted non-aromatic carbocycle, or substituted or unsubstituted non-aromatic heterocycle,
or, optionally, R4a and R4b are taken together with the adjacent carbon atom to form substituted or unsubstituted non-aromatic carbocycle or substituted or unsubstituted non-aromatic heterocycle;
R5 is each independently halogen, hydroxy, cyano, carboxy, substituted or unsubstituted carbamoyl, substituted or unsubstituted thiocarbamoyl, substituted or unsubstituted amidino, substituted or unsubstituted amino, substituted or unsubstituted ureido, substituted or unsubstituted guanidino, pentafluorothio, sulfo, substituted or unsubstituted sulfamoyl, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted alkyloxy, substituted or unsubstituted alkenyloxy, substituted or unsubstituted alkynyloxy, substituted or unsubstituted alkylcarbonyloxy, substituted or unsubstituted alkenylcarbonyloxy, substituted or unsubstituted alkynylcarbonyloxy, substituted or unsubstituted alkylcarbonyl, substituted or unsubstituted alkenylcarbonyl, substituted or unsubstituted alkynylcarbonyl, substituted or unsubstituted alkyloxycarbonyl, substituted or unsubstituted alkenyloxycarbonyl, substituted or unsubstituted alkynyloxycarbonyl, substituted or unsubstituted alkylsulfanyl, substituted or unsubstituted alkenylsulfanyl, substituted or unsubstituted alkynylsulfanyl, substituted or unsubstituted alkylsulfinyl, substituted or unsubstituted alkenylsulfinyl, substituted or unsubstituted alkynylsulfinyl, substituted or unsubstituted alkylsulfonyl, substituted or unsubstituted alkenylsulfonyl, substituted or unsubstituted alkynylsulfonyl, substituted or unsubstituted aromatic carbocyclyl, substituted or unsubstituted non-aromatic carbocyclyl, substituted or unsubstituted aromatic heterocyclyl, substituted or unsubstituted non-aromatic heterocyclyl, substituted or unsubstituted aromatic carbocyclyloxy, substituted or unsubstituted non-aromatic carbocyclyloxy, substituted or unsubstituted aromatic heterocyclyloxy, substituted or unsubstituted non-aromatic heterocyclyloxy, substituted or unsubstituted aromatic carbocyclylcarbonyloxy, substituted or unsubstituted non-aromatic carbocyclylcarbonyloxy, substituted or unsubstituted aromatic heterocyclylcarbonyloxy, substituted or unsubstituted non-aromatic heterocyclylcarbonyloxy, substituted or unsubstituted aromatic carbocyclylcarbonyl, substituted or unsubstituted non-aromatic carbocyclylcarbonyl, substituted or unsubstituted aromatic heterocyclylcarbonyl, substituted or unsubstituted non-aromatic heterocyclylcarbonyl, substituted or unsubstituted aromatic carbocyclyloxycarbonyl, substituted or unsubstituted non-aromatic carbocyclyloxycarbonyl, substituted or unsubstituted aromatic heterocyclyloxycarbonyl, substituted or unsubstituted non-aromatic heterocyclyloxycarbonyl, substituted or unsubstituted aromatic carbocyclylsulfanyl, substituted or unsubstituted non-aromatic carbocyclylsulfanyl, substituted or unsubstituted aromatic heterocyclylsulfanyl, substituted or unsubstituted non-aromatic heterocyclylsulfanyl, substituted or unsubstituted aromatic carbocyclylsulfinyl, substituted or unsubstituted non-aromatic carbocyclylsulfinyl, substituted or unsubstituted aromatic heterocyclylsulfinyl, substituted or unsubstituted non-aromatic heterocyclylsulfinyl, substituted or unsubstituted aromatic carbocyclylsulfonyl, substituted or unsubstituted non-aromatic carbocyclylsulfonyl, substituted or unsubstituted aromatic heterocyclylsulfonyl, substituted or unsubstituted non-aromatic heterocyclylsulfonyl, a group represented by the formula: -L1-N?S(?O)(—RS1)—RS2, a group represented by the formula: -L1-S(?O)(?N—RN)—RS1, a group represented by the formula: —N?S(?N—RN)(—RS1)—RS2, or a group represented by the formula: —S(?N—RN)2—RS1;
R6 is each independently halogen, hydroxy, cyano, carboxy, substituted or unsubstituted carbamoyl, substituted or unsubstituted thiocarbamoyl, substituted or unsubstituted amidino, substituted or unsubstituted amino, substituted or unsubstituted ureido, substituted or unsubstituted guanidino, pentafluorothio, sulfo, substituted or unsubstituted sulfamoyl, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted alkyloxy, substituted or unsubstituted alkenyloxy, substituted or unsubstituted alkynyloxy, substituted or unsubstituted alkylcarbonyloxy, substituted or unsubstituted alkenylcarbonyloxy, substituted or unsubstituted alkynylcarbonyloxy, substituted or unsubstituted alkylcarbonyl, substituted or unsubstituted alkenylcarbonyl, substituted or unsubstituted alkynylcarbonyl, substituted or unsubstituted alkyloxycarbonyl, substituted or unsubstituted alkenyloxycarbonyl, substituted or unsubstituted alkynyloxycarbonyl, substituted or unsubstituted alkylsulfanyl, substituted or unsubstituted alkenylsulfanyl, substituted or unsubstituted alkynylsulfanyl, substituted or unsubstituted alkylsulfinyl, substituted or unsubstituted alkenylsulfinyl, substituted or unsubstituted alkynylsulfinyl, substituted or unsubstituted alkylsulfonyl, substituted or unsubstituted alkenylsulfonyl, substituted or unsubstituted alkynylsulfonyl, substituted or unsubstituted aromatic carbocyclyl, substituted or unsubstituted non-aromatic carbocyclyl, substituted or unsubstituted aromatic heterocyclyl, substituted or unsubstituted non-aromatic heterocyclyl, substituted or unsubstituted aromatic carbocyclyloxy, substituted or unsubstituted non-aromatic carbocyclyloxy, substituted or unsubstituted aromatic heterocyclyloxy, substituted or unsubstituted non-aromatic heterocyclyloxy, substituted or unsubstituted aromatic carbocyclylcarbonyloxy, substituted or unsubstituted non-aromatic carbocyclylcarbonyloxy, substituted or unsubstituted aromatic heterocyclylcarbonyloxy, substituted or unsubstituted non-aromatic heterocyclylcarbonyloxy, substituted or unsubstituted aromatic carbocyclylcarbonyl, substituted or unsubstituted non-aromatic carbocyclylcarbonyl, substituted or unsubstituted aromatic heterocyclylcarbonyl, substituted or unsubstituted non-aromatic heterocyclylcarbonyl, substituted or unsubstituted aromatic carbocyclyloxycarbonyl, substituted or unsubstituted non-aromatic carbocyclyloxycarbonyl, substituted or unsubstituted aromatic heterocyclyloxycarbonyl, substituted or unsubstituted non-aromatic heterocyclyloxycarbonyl, substituted or unsubstituted aromatic carbocyclylsulfanyl, substituted or unsubstituted non-aromatic carbocyclylsulfanyl, substituted or unsubstituted aromatic heterocyclylsulfanyl, substituted or unsubstituted non-aromatic heterocyclylsulfanyl, substituted or unsubstituted aromatic carbocyclylsulfinyl, substituted or unsubstituted non-aromatic carbocyclylsulfinyl, substituted or unsubstituted aromatic heterocyclylsulfinyl, substituted or unsubstituted non-aromatic heterocyclylsulfinyl, substituted or unsubstituted aromatic carbocyclylsulfonyl, substituted or unsubstituted non-aromatic carbocyclylsulfonyl, substituted or unsubstituted aromatic heterocyclylsulfonyl, substituted or unsubstituted non-aromatic heterocyclylsulfonyl, a group represented by the formula: -L1-N?S(?O)(—RS1)—RS2, a group represented by the formula: -L1-S(?O)(?N—RN)—RS1, a group represented by the formula: —N?S(?N—RN)(—RS1)—RS2, or a group represented by the formula: —S(?N—RN)2—RS1;
R7a is each independently hydrogen, halogen, hydroxy, cyano, substituted or unsubstituted amino, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted alkyloxy, substituted or unsubstituted alkenyloxy, substituted or unsubstituted alkynyloxy, substituted or unsubstituted alkylsulfonyl, substituted or unsubstituted alkenylsulfonyl, substituted or unsubstituted alkynylsulfonyl, substituted or unsubstituted aromatic carbocyclyl, substituted or unsubstituted non-aromatic carbocyclyl, substituted or unsubstituted aromatic heterocyclyl, substituted or unsubstituted non-aromatic heterocyclyl, substituted or unsubstituted aromatic carbocyclyloxy, substituted or unsubstituted non-aromatic carbocyclyloxy, substituted or unsubstituted aromatic heterocyclyloxy, substituted or unsubstituted non-aromatic heterocyclyloxy, substituted or unsubstituted aromatic carbocyclylsulfonyl, substituted or unsubstituted non-aromatic carbocyclylsulfonyl, substituted or unsubstituted aromatic heterocyclylsulfonyl, or substituted or unsubstituted non-aromatic heterocyclylsulfonyl, and
R7b is each independently hydrogen, halogen, hydroxy, cyano, substituted or unsubstituted amino, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted alkyloxy, substituted or unsubstituted alkenyloxy, substituted or unsubstituted alkynyloxy, substituted or unsubstituted alkylsulfonyl, substituted or unsubstituted alkenylsulfonyl, substituted or unsubstituted alkynylsulfonyl, substituted or unsubstituted aromatic carbocyclyl, substituted or unsubstituted non-aromatic carbocyclyl, substituted or unsubstituted aromatic heterocyclyl, substituted or unsubstituted non-aromatic heterocyclyl, substituted or unsubstituted aromatic carbocyclyloxy, substituted or unsubstituted non-aromatic carbocyclyloxy, substituted or unsubstituted aromatic heterocyclyloxy, substituted or unsubstituted non-aromatic heterocyclyloxy, substituted or unsubstituted aromatic carbocyclylsulfonyl, substituted or unsubstituted non-aromatic carbocyclylsulfonyl, substituted or unsubstituted aromatic heterocyclylsulfonyl, or substituted or unsubstituted non-aromatic heterocyclylsulfonyl,
or, optionally, R7a and R7b attached to the same carbon atom are taken together with the adjacent carbon atom to form substituted or unsubstituted non-aromatic carbocycle or substituted or unsubstituted non-aromatic heterocycle;
R8 is hydrogen or substituted or unsubstituted alkyl;
R9 is hydrogen, substituted or unsubstituted amino, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted alkylcarbonyl, substituted or unsubstituted alkenylcarbonyl, substituted or unsubstituted alkynylcarbonyl, substituted or unsubstituted alkyloxycarbonyl, substituted or unsubstituted alkenyloxycarbonyl, substituted or unsubstituted alkynyloxycarbonyl, substituted or unsubstituted alkylsulfonyl, substituted or unsubstituted alkenylsulfonyl, substituted or unsubstituted alkynylsulfonyl, substituted or unsubstituted aromatic carbocyclyl, substituted or unsubstituted non-aromatic carbocyclyl, substituted or unsubstituted aromatic heterocyclyl, substituted or unsubstituted non-aromatic heterocyclyl, substituted or unsubstituted aromatic carbocyclylcarbonyl, substituted or unsubstituted non-aromatic carbocyclylcarbonyl, substituted or unsubstituted aromatic heterocyclylcarbonyl, substituted or unsubstituted non-aromatic heterocyclylcarbonyl, substituted or unsubstituted aromatic carbocyclyloxycarbonyl, substituted or unsubstituted non-aromatic carbocyclyloxycarbonyl, substituted or unsubstituted aromatic heterocyclyloxycarbonyl, substituted or unsubstituted non-aromatic heterocyclyloxycarbonyl, substituted or unsubstituted aromatic carbocyclylsulfonyl, substituted or unsubstituted non-aromatic carbocyclylsulfonyl, substituted or unsubstituted aromatic heterocyclylsulfonyl, or substituted or unsubstituted non-aromatic heterocyclylsulfonyl;
L1 is each independently a single bond, alkylene, or C(?O);
RS1 and RS2 are each independently hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted aromatic carbocyclyl, substituted or unsubstituted non-aromatic carbocyclyl, substituted or unsubstituted aromatic heterocyclyl, or substituted or unsubstituted non-aromatic heterocyclyl, or, optionally, RS1 and RS2 bonding to the same sulfur atom are taken together with the sulfur atom to form substituted or unsubstituted non-aromatic heterocycle;
RN is each independently hydrogen, cyano, substituted or unsubstituted carbamoyl, substituted or unsubstituted alkyl, substituted or unsubstituted alkylcarbonyl, substituted or unsubstituted alkyloxycarbonyl, substituted or unsubstituted aromatic carbocyclyl, substituted or unsubstituted non-aromatic carbocyclyl, substituted or unsubstituted aromatic heterocyclyl, substituted or unsubstituted non-aromatic heterocyclyl, substituted or unsubstituted aromatic carbocyclylcarbonyl, substituted or unsubstituted non-aromatic carbocyclylcarbonyl, substituted or unsubstituted aromatic heterocyclylcarbonyl, or substituted or unsubstituted non-aromatic heterocyclylcarbonyl;
m is an integer of 0 to 5;
n is an integer of 0 to 5; and
p is an integer of 1 to 6,or its pharmaceutically acceptable salt.

US Pat. No. 10,335,400

TREATMENT OF TAUOPATHIES WITH MGLUR5 ANTAGONISTS

The Research Foundation f...

1. A method of treating Parkinsonism-dementia complex of Guam, comprising the step of administering a pharmaceutically effective amount of an mGluR5 antagonist to a subject in need thereof to minimize a tau hyperphosphorylation in a brain thereof, wherein the mGluR5 antagonist is 2-methyl-6-(phenylethynyl) pyridine.

US Pat. No. 10,335,399

CHROMANE, ISOCHROMANE AND DIHYDROISOBENZOFURAN DERIVATIVES AS MGLUR2—NEGATIVE ALLOSTERIC MODULATORS, COMPOSITIONS, AND THEIR USE

1. A compound having the structure:

US Pat. No. 10,335,396

METHODS OF REVERSING AUTONOMIC NERVOUS SYSTEM DAMAGE

1. A method for reducing parasympathetic excess (PE) in a subject in need thereof, comprising:administering to said subject rifaximin, wherein rifaximin is administered for 10-14 days; a polyunsaturated omega-3 fatty acid, wherein the polyunsaturated omega-3 fatty acid comprises DHA in a daily concentration range selected from: about 2,000-4,000 mg, or about 3,000 mg; and olive oil, wherein the olive oil is administered daily in an amount selected from: about 5 ml to about 100 ml, about 10 ml to about 75 ml, about 15 ml to about 50 ml, about 20 ml to about 40 ml, or about 25 ml;
providing VNS (vagal nerve stimulation) to the subject, wherein the VNS is provided transcutaneously using electrical stimulation, wherein the electrical stimulation is achieved by clipping electrodes across the tragus of an ear and inducing an electrical current with a transcutaneous electrical nerve stimulation (TENS) unit; and
placing said subject on an intermittent fasting regimen, wherein the intermittent fasting regimen comprises fasting for multiple days but not on consecutive days; and
wherein the prevalence of parasympathetic excess (PE) is decreased.

US Pat. No. 10,335,394

PROCESSES FOR PREPARING DOLUTEGRAVIR AND CABOTEGRAVIR AND ANALOGUES THEREOF

Lek Pharmaceuticals d.d.,...

1. A process for preparing a compound of formula (I) or a salt thereof
wherein
A represents CH2 or CH2—CH2,
R represents H, C1-C4 alkyl or unsubstituted or substituted phenyl,
X represents O, S, or N—R5, wherein R5 is H or C1-C4 alkyl,
Z represents hydroxy, C1-C4 alkoxy, phenoxy, benzoxy, —NH—Ar or—NH—CH2—Ar,
wherein Ar represents unsubstituted or substituted phenyl, and
* represents a chirality center, which is of (R) or (S) configuration,
the process comprising the steps of
(a) providing a compound of formula (II) or a salt thereof,

wherein A, R, X, Z, and * have the same meaning as above and
Y represents Cl or O—Ra,
wherein Ra represents C1-C4 alkyl or benzyl,
and
(b) carrying out a chemical transformation to obtain the compound of formula (I) and/or a salt thereof,
wherein the transformation is carried out in the presence of a hydroxide and methanol and/or ethanol.

US Pat. No. 10,335,393

NUCLEAR TRANSPORT MODULATORS AND USES THEREOF

Biogen MA Inc., Cambridg...

1. A compound of formula I:
or a pharmaceutically acceptable salt thereof, wherein:
R1 is selected from hydrogen and C1-C4 alkyl;
R2 is selected from O; and
R3 is —C1-C6 alkyl, wherein R3 is optionally and independently substituted with one or more substituents selected from the group consisting of —OH, —SH, nitro, halogen, amino, cyano, C1-C12 alkyl, C2-C12 alkenyl or C2-C12 alkynyl group, C1-C12 alkoxy, C1-C12 haloalkyl, C1-C12 haloalkoxy and C1-C12 alkyl sulfanyl.

US Pat. No. 10,335,392

CYCLIC COMPOUNDS USEFUL AS MODULATORS OF TNF ?

Bristol-Myers Squibb Comp...

1. A compound of Formula (I)
or a salt thereof, wherein:
Ring A is 3- to 5-membered carbocyclic ring or 3- to 6-membered heterocyclic ring;
X is CR1 or N;
Y is —(CR5R5)m—;
Z is —(CR5R5)n—;
m is zero, 1 or 2;
n is zero, 1 or 2; provided that m+n is zero, 1, or 2;
R1 is H, halo, —CN, C1-4 alkyl, C1-4 haloalkyl, or C1-4 alkoxy;
R2 is H, R1a, C1-6 haloalkyl, C2-6 alkenyl substituted with zero to 6 R1a, C2-6 alkynyl substituted with zero to 4 R1a, —(CRgRg)r(3- to 14-membered carbocyclyl substituted with zero to 3 R1a), —(CRgRg)r(aryl substituted with zero to 3 R1a), —(CRgRg)r(5- to 7-membered heterocyclyl substituted with zero to 3 R1a), or —(CRgRg)r(mono- or bicyclic heteroaryl substituted with zero to 3 R1a);
R3 is H, halo, —CN, —CF3, —OCF3, —NO2, C1-6 alkyl substituted with zero to 6 R1a, —(CRgRg)rORe, —(CRgRg)rNRcRc, —(CRgRg)rS(O)pRb, —(CRgRg)r(3- to 14-membered carbocyclyl substituted with zero to 3 R1a), —(CRgRg)r(aryl substituted with zero to 3 R1a), —(CRgRg)r(5- to 7-membered heterocyclyl substituted with zero to 3 R1a), or —(CRgRg)r(monocyclic or bicyclic heteroaryl substituted with zero to 3 R1a);
R4 is H, halo, —CN, C1-4 alkyl, C1-4 haloalkyl, or C1-4 alkoxy;
each R5 is independently H, halo, —CN, C1-6 alkyl substituted with zero to 6 Rh, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, —(CRgRg)rC(O)Rb, —(CRgRg)rC(O)ORb, —(CRgRg)rC(O)NRcRc, —(CRgRg)rORe, —(CRgRg)rOC(O)Rb, —(CRgRg)rOC(O)NRcRc, —(CRgRg)rOC(O)ORd, —(CRgRg)rNRcRc, —(CRgRg)rNRbC(O)Rd, —(CRgRg)rNRbC(O)ORd, —(CRgRg)rNRbC(O)NRcRc, —(CRgRg)rNRbS(O)pRd, —(CRgRg)rS(O)pRb, —(CRgRg)rS(O)pNRcRc, —(CRgRg)r(3- to 14-membered carbocyclyl substituted with zero to 3 R1a), —(CRgRg)r(aryl substituted with zero to 3 R1a), —(CRgRg)r(5- to 7-membered heterocyclyl substituted with zero to 3 R1a), or —(CRgRg)r(mono- or bicyclic heteroaryl substituted with zero to 3 R1a); or two R5 along with the carbon atom to which they are attached form C?O, C?NORb, or 3- to 6-membered spirocarbocyclic or spiroheterocyclic ring substituted with zero to 3 Ri;
R6 and R8 are independently H, halo, —OH, —CN, C1-5 alkyl, C1-5 hydroxyalkyl, C1-5 haloalkyl, C1-5 alkoxy, —NRxRx, —OC(O)NRxRx, —NRxC(O)ORy, —NRxC(O)Ry, —(CRgRg)r(3- to 14-membered carbocyclyl substituted with zero to 3 R1a), —(CRgRg)r(aryl substituted with zero to 3 R1a), —(CRgRg)r(5- to 10-membered heterocyclyl substituted with zero to 3 R1a), or —(CRgRg)r(mono- or bicyclic heteroaryl substituted with zero to 3 R1a);
each R7 is independently halo, —OH, —CN, C1-5 alkyl, C1-5 hydroxyalkyl, C1-5 haloalkyl, —NRxRx, C1-5 alkoxy, —OC(O)NRxRx, —NRxC(O)ORy, —NRxC(O)Ry, —(CRgRg)r(3- to 14-membered carbocyclyl substituted with zero to 3 R1a), —(CRgRg)r(aryl substituted with zero to 3 R1a), —(CRgRg)r(5- to 10-membered heterocyclyl substituted with zero to 3 R1a), or —(CRgRg)r(mono- or bicyclic heteroaryl substituted with zero to 3 R1a);
R9 is —(CRgRg)r(3- to 14-membered carbocyclyl substituted with zero to 3 R1a), —(CRgRg)r(aryl substituted with zero to 3 R1a), —(CRgRg)r(5- to 10-membered heterocyclyl substituted with zero to 3 R1a), or —(CRgRg)r(mono- or bicyclic heteroaryl substituted with zero to 3 R1a);
R10 is H, C1-6 alkyl, or C1-6 haloalkyl;
or R9 and R10 together with the carbon atom to which they are attached form a 5- to 6-membered spirocarbocyclic or spiroheterocyclic ring, substituted with zero to 6 Ri;
each R1a is independently F, Cl, Br, —CN, C1-6 alkyl substituted with zero to 6 Ra, C3-6 cycloalkyl substituted with zero to 6 Ra, C1-3 alkoxy substituted with zero to 6 Ra, C1-3 haloalkoxy, 5- to 7-membered heterocyclyl substituted with zero to 6 Ra, aryl substituted with zero to 6 Ra, mono- or bicyclic heteroaryl substituted with zero to 6 Ra, —C(O)Rb, —C(O)ORb, —C(O)NRcRc, —OC(O)Rb, —OC(O)NRcRc, —OC(O)ORd, —NRcRc, —NRbC(O)Rd, —NRbC(O)ORd, —NRbS(O)pRd, —NRbC(O)NRcRc, —NRbS(O)pNRcRc, —S(O)pRb, —S(O)pNRcRc, or —C(O)NRb(CH2)1-3NRcRc;
each Ra is independently halo, —CN, —OH, —NO2, —NH2, C1-3 alkyl, C1-3 fluoroalkyl, C2-4 alkenyl, C2-4 alkynyl, C1-3 alkoxy, C1-3 fluoroalkoxy, —(CH2)rC(O)OH, —C(O)(C1-3 alkyl), —C(O)O(C1-4 alkyl), —OC(O)(C1-3 alkyl), —NH(C1-3 alkyl), —N(C1-3 alkyl)2, —C(O)NH(C1-3 alkyl), —OC(O)NH(C1-3 alkyl), —NHC(O)NH(C1-3 alkyl), —C(?NH)(NH2), C3-7 carbocyclyl, aryl, 5- to 7-membered heterocyclyl, mono- or bicyclic heteroaryl, —O(aryl), —O(benzyl), —O(heterocyclyl), —S(O)p(C1-3 alkyl), —S(O)p(aryl), —S(O)p(heterocyclyl), —NHS(O)2(aryl), —NHS(O)2(heterocyclyl), —NHS(O)2NH(aryl), —NHS(O)2NH(heterocyclyl), —NH(aryl), —NH(heterocyclyl), —NHC(O)(aryl), —NHC(O)(C1-3 alkyl), —NHC(O)(heterocyclyl), —OC(O)(aryl), —OC(O)(heterocyclyl), —NHC(O)NH(aryl), —NHC(O)NH(heterocyclyl), —OC(O)O(C1-3 alkyl), —OC(O)O(aryl), —OC(O)O(heterocyclyl), —OC(O)NH(aryl), —OC(O)NH(heterocyclyl), —NHC(O)O(aryl), —NHC(O)O(heterocyclyl), —NHC(O)O(C1-3 alkyl), —C(O)NH(aryl), —C(O)NH(heterocyclyl), —C(O)O(aryl), —C(O)O(heterocyclyl), —N(C1-3 alkyl)S(O)2(aryl), —N(C1-3 alkyl)S(O)2(heterocyclyl), —N(C1-3 alkyl)S(O)2NH(aryl), —N(C1-3 alkyl)S(O)2NH(heterocyclyl), —N(C1-3 alkyl)(aryl), —N(C1-3 alkyl)(heterocyclyl), —N(C1-3 alkyl)C(O)(aryl), —N(C1-3 alkyl)C(O)(heterocyclyl), —N(C1-3 alkyl)CO2H —N(C1-3 alkyl)C(O)NH(aryl), —(CH2)0-3C(O)NH(heterocyclyl), —OC(O)N(C1-3 alkyl)(aryl), —OC(O)N(C1-3 alkyl)(heterocyclyl), —N(C1-3 alkyl)C(O)O(aryl), —N(C1-3 alkyl)C(O)O(heterocyclyl), —C(O)N(C1-3 alkyl)(aryl), —C(O)N(C1-3 alkyl)(heterocyclyl), —NHS(O)2N(C1-3 alkyl)(aryl), —NHS(O)2N(C1-3 alkyl)(heterocyclyl), —NHP(O)2N(C1-3 alkyl)(aryl), —NHC(O)N(C1-3 alkyl)(aryl), —NHC(O)N(C1-3 alkyl)(heterocyclyl), —N(C1-3 alkyl)S(O)2N(C1-3 alkyl)(aryl), —N(C1-3 alkyl)S(O)2N(C1-3 alkyl)(heterocyclyl), —N(C1-3 alkyl)C(O)N(C1-3 alkyl)(aryl), —N(C1-3 alkyl)C(O)N(C1-3 alkyl)(heterocyclyl), or —Si(C1-3 alkyl)3; or two Ra attached to the same carbon atom form ?O;
each Rb is independently H, C1-6 alkyl substituted with zero to 6 Rf, C3-7 cycloalkyl substituted with zero to 6 Rf, mono- or bicyclic heterocyclyl substituted with zero to 6 Rf, aryl substituted with zero to 3 Rf, or mono- or bicyclic heteroaryl substituted with zero to 3 Rf;
each Rc is independently H, C1-6 alkyl substituted with zero to 6 Rf, C3-7 cycloalkyl substituted with zero to 6 Rf, mono- or bicyclic heterocyclyl substituted with zero to 6 Rf, aryl substituted with zero to 3 Rf, or mono- or bicyclic heteroaryl substituted with zero to 3 Rf; or when attached to the same nitrogen, two Rc along with the nitrogen atom to which they are attached form 4- to 8-membered heterocyclic ring substituted with zero to 3 Rg;
each Rd is independently H, C1-6 alkyl substituted with zero to 6 Rf, C3-7 cycloalkyl substituted with zero to 6 Rf, mono- or bicyclic heterocyclyl substituted with zero to 6 Rf, aryl substituted with zero to 3 Rf, or mono- or bicyclic heteroaryl substituted with zero to 3 Rf;
each Re is independently H, C1-6 alkyl substituted with zero to 6 Rf, C1-3 haloalkyl, C3-7 cycloalkyl substituted with zero to 6 Rf, mono- or bicyclic heterocyclyl substituted with zero to 6 Rf, aryl substituted with zero to 3 Rf, or mono- or bicyclic heteroaryl substituted with zero to 3 Rf;
each Rf is independently H, halo, —OH, —CN, C1-6 alkyl substituted with zero to 6 Ra, C1-3 alkoxy, C3-7 cycloalkyl substituted with zero to 6 Ra, mono- or bicyclic heterocyclyl substituted with zero to 6 Ra, aryl substituted with zero to 3 Ra, or mono- or bicyclic heteroaryl substituted with zero to 3 Ra;
each Rg is independently H, F, —OH, —CN, C1-3 alkyl, —CF3, or phenyl;
each Rh is independently —OH or halo;
each Ri is independently H, halo, —CN, —OH, C1-3 alkyl, C1-3 fluoroalkyl, or C1-3 alkoxy; or two Ri attached to the same carbon atom of the spirocarbocyclic or spiroheterocyclic ring, form ?O; or two Ri attached to neighboring carbon atoms of the spirocarbocyclic or spiroheterocyclic ring, form a benzo ring along with the carbon atoms to which they are attached, said benzo ring substituted with zero to 4 Rf;
each Rx is independently H or C1-5 alkyl;
each Ry is independently C1-5 alkyl;
each p is independently zero, 1, or 2;
q is zero, 1, or 2; and
each r is independently zero, 1, 2, 3, or 4.

US Pat. No. 10,335,388

COMBINATION THERAPY OF A HIF-2-ALPHA INHIBITOR AND AN IMMUNOTHERAPEUTIC AGENT AND USES THEREOF

PELOTON THERAPEUTICS, INC...

1. A method of treating cancer in a subject in need thereof, comprising administering to said subject an effective amount of a HIF-2? inhibitor in combination B with an immunotherapeutic agent, wherein the cancer is selected from the group consisting of melanoma, renal cell carcinoma, and colorectal cancer, wherein the immunotherapeutic agent is a PD-1 inhibitor or a CTLA-4 inhibitor, and wherein the HIF-2? inhibitor is a compound of Formula I-C:
or a pharmaceutically acceptable salt thereof, wherein:
X is CR5 or N;
Y is CR6 or N;
Z is —O—, —S—, —C(HR7)—, —N(R8)— or absent;
R1 is alkyl, heteroalkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, acyl or cyano;
R4 is nitro, halo, cyano, alkyl, cycloalkyl, heteroaryl, carboxyl, sulfinyl, sulfonamidyl, sulfonyl or sulfoximinyl;
R5, R6, R7 and R8 are independently hydrogen, halo, hydroxy, cyano, alkyl or alkoxy;
R11 is hydrogen, halo, hydroxy, alkoxy or amino;
R12 is hydrogen, alkyl, alkenyl or alkynyl; or R11 and R12 in combination form oxo or oxime;
each of R13 is independently selected from the group consisting of hydrogen, fluoro, chloro, hydroxy, alkyl and heteroalkyl; or two R13s and the carbon atom(s) to which they are attached form a 3- to 8-membered cycloalkyl or heterocycloalkyl moiety; and
n is 0, 1, 2, 3 or 4.

US Pat. No. 10,335,386

LIPID COMPRISING POLYUNSATURATED FATTY ACIDS

COMMONWEALTH SCIENTIFIC A...

1. Canola oil extracted from Brassica napus seed, comprising a total fatty acid content which comprises docosahexaenoic acid (DHA, 22:6?3), wherein the DHA is present at a level of between 7% and 20% of the total fatty acid content, wherein at least 70% of the DHA in the total fatty acid content is esterified at the sn-1 or sn-3 position of triacylglycerol (TAG) in the canola oil.

US Pat. No. 10,335,383

OAT FRACTIONS WITH ENHANCED AVENANTHRAMIDE CONCENTRATION AND METHODS OF MAKING

The Quaker Oats Company, ...

1. A food product comprising an infrared-treated oat flour made by exposing a pre-treatment oat flour to infrared energy so that the infrared-treated oat flour has a higher concentration of total Avenanthramides than the pre-treatment oat flour,wherein the amount of Avenanthramides in the food product is sufficient to provide a health benefit to a human upon oral ingestion of the food product by the human,
wherein the concentration of total Avenanthramides in the infrared-treated oat flour is higher than the concentration of total Avenanthramides that occurs naturally in the pre-treatment oat flour,
wherein the infrared-treated oat flour has been treated by exposure to infrared energy so that the concentration of total Avenanthramides in the infrared-treated oat flour is increased by at least 5 wt. % relative to the concentration of total Avenanthramides in the pre-treatment oat flour, wherein the pre-treatment oat flour is untreated for Avenanthramides enhancement,
wherein the exposure includes exposing the pre-treatment oat flour to from 2 to 15 kJ of infrared energy per gram of the pre-treatment oat flour,
wherein the infrared-treated oat flour is untreated with enzymes to increase the concentration of Avenanthramides, and
wherein the infrared-treated oat flour is untreated with fungal agents to increase the concentration of Avenanthramides.

US Pat. No. 10,335,382

USE OF HYDROGEN SULFIDE SYNTHESIS INHIBITORS FOR CANCER THERAPY

THE BOARD OF REGENTS OF T...

1. A cystathionine-?-synthase (CBS) inhibitor having a chemical structure of Formula I,
wherein R1 is a 3-pentyl group, wherein the compound inhibits CBS.

US Pat. No. 10,335,379

ORAL DOSAGE FORMS OF KETAMINE

Develco Pharma Schweiz AG...

1. An oral dosage form comprising ketamine or a pharmaceutically acceptable salt or solvate thereof,wherein the dosage form provides an in vitro release of ketamine, when measured according to the USP Basket Method I in 0.1M HCl at 37° C. at 100 rpm, of 0 to 40% after 2 hours, of 10 to 70% after 4 hours, of 30 to 85% after 6 hours and of 45 to 100% after 8 hours,
wherein the dosage form provides an in vitro release of ketamine, when measured according to the USP 1 Basket Method in 0.1M HCl at 100 rpm, after one hour at 37° C., in an aqueous solution containing 20% by volume of ethanol, in a ratio of less than 2:1 relative to the amount of ketamine released, so measured, after one hour at 37° C. in an ethanol-free aqueous solution,
wherein the dosage form is a multi-particulate controlled release tablet,
wherein the tablet comprises pellets each containing
i) a core comprising
1 to 30 wt. % inert beads,
5 to 400 mg and 1 to 40 wt. % ketamine hydrochloride,
0.01 to 10 wt. % binder, and
0 to 10 wt. % glidant, and
ii) a release control layer comprising
1 to 40 wt. % of a release control substance coated upon the core, wherein the release control substance is a water insoluble polymer,
0.01 to 10 wt % pore builder,
0.01 to 10 wt. % plasticizer, and
0 to 15 wt. % glidant, and
wherein the pellets are contained in an external phase comprising
carboxymethyl cellulose, optionally in the form of a salt, as a pharmaceutically acceptable excipient,
20 to 85 wt. % filler,
0 to 3 wt. % lubricant, and
0 to 5 wt. % glidant,
wherein the tablet optionally comprises an external film coating, and
wherein all wt. % are based on the total weight of the tablet, without the film coating.

US Pat. No. 10,335,361

COSMETIC PROCESS FOR MAKING-UP AND/OR CARING FOR THE SKIN AND/OR THE LIPS

1. A cosmetic process for making up and/or caring for skin and/or lips, comprising applying a cosmetic composition to the skin and/or the lips, the cosmetic composition comprising, in a physiologically acceptable medium:supramolecular polymer having the formula:

the supramolecular polymer being present in an amount in a range of from 0.3 to 40% by weight relative to a total weight of the composition; and
at least one hydrophobic film-forming polymer in an amount in a range of from 0.2 to 20% by weight relative to a total weight of the composition, the hydrophobic film-forming polymer being a vinyl polymer bearing a carbosiloxane dendrimer-based unit having a formula selected from the group consisting of:

US Pat. No. 10,335,358

HAIR COSMETIC

KAO CORPORATION, Tokyo (...

1. A hair cosmetic comprising ingredients (A) and (B):(A) from 0.37 to 5 mass % of a cationic polymer having a charge density of 5.0 meq/g or more and 6.2 meq/g or less; and
(B) from 0.61 to 2.52 mass % of an anionic polysaccharide derivative wherein a part of the hydrogen atoms of the hydroxyl group of a polysaccharide compound having a constituent unit represented by formula (1) are substituted with —(CH2)mCOO? group, wherein m is an integer of 1 to 5, at an average substitution degree of from 0.7 to 0.85 per constituent unit, and wherein optionally a part of the hydrogen atoms of the remaining hydroxyl groups are substituted with linear or branched C1-40 alkyl groups, alkylene groups, or a combination thereof;
wherein:
a mass ratio of ingredient (A) to ingredient (B), (A)/(B), is from 0.2 to 1.5;
a viscosity of ingredient (B) in a 2 mass % aqueous solution at 25° C. is from 3 mPa·s to 298 mPa·s; and
formula (1) is:
wherein each R?, independently, represents a C2-4 linear alkylene group optionally substituted with a hydroxyl group or a C2-4 branched alkylene group optionally substituted with a hydroxyl group, and n represents a number by which the average number of added moles of R?O per constituent unit is 0 to 10.

US Pat. No. 10,335,351

PERSONAL CARE ARTICLES AND METHODS

1. A compliant personal cleansing article, comprising:a) cleansing composition, comprising a rheology modifier and from about 10% to about 70%, by weight of the composition, of a synthetic surfactant; and
b) a water penetrable first substrate surrounding the composition; wherein the article has a compliance of about 1.50 kg/mm or less.

US Pat. No. 10,335,350

PACIFIER WHICH HELPS WEAN TODDLERS OFF PACIFIERS

1. A pacifier, intended for use with infants of suitable age to wean a child from continued pacifier use without anger, anxiety or stress, comprising:a) a teat structure for allowing the child to suck upon it;
b) a mouth shield arranged generally perpendicularly to the teat and joined therewith so as to be generally inseparable therefrom, said mouth shield defining an outermost edge of the pacifier, said mouth shield comprising apertures extending through said mouth shield, said apertures being disposed radially outward from the teat structure; and
c) a flexible sheet having bristle structures projecting therefrom, said bristle structures covering an entire surface of said mouth shield from an outermost edge of the mouth shield to a position adjacent the teat, wherein said flexible sheet comprises apertures extending through said flexible sheet, wherein the apertures of the mouth shield are axially aligned with said apertures of the flexible sheet, wherein said bristle structures project in the same direction as the teat to slightly irritate the face and mouth of the child during use thereby discouraging continued use of the pacifier.

US Pat. No. 10,335,348

FILLING NEEDLE FOR USE IN A TUBE LAYER FOR TRANSFERRING A FLOWABLE MEDIUM, IN PARTICULAR A PHARMACEUTICAL PRODUCT

1. A filling needle for use in a tube set for transferring a flowable medium, the filling needle comprising:a needle end for temporary insertion into a filling vessel;
a connector end for connecting the filling needle to a filling device via which the medium can be supplied to the filling needle;
an inner tube layer made of silicone, defining an inner tube lumen;
an outer reinforcing tube layer made of a plastic reinforcing material, encasing the inner tube lumen; and
a bonding agent between the inner tube layer and the reinforcing tube layer,
wherein the bonding agent includes bonding bodies which mechanically bond the two tube layers, and
wherein the filling needle on the whole is made entirely of plastic.

US Pat. No. 10,335,347

CLOSING SYSTEM FOR A CONTAINER

Becton Dickinson France, ...

1. A closing system for a container, the closing system comprising:a cap comprising a skirt and a transversal wall provided with an access port;
a cover parallel to the cap, the cover comprising a proximal face having a protrusion extending therefrom and a proximally curved pushing surface extending from the proximal face, said proximally curved pushing surface and said protrusion each extending from the proximal face, but offset from one another; and
a hinge allowing a planar rotation of the cover regarding the cap from a first position closing the access port to a second position giving access to the access port,
wherein the cover further comprises a front portion, a rear portion, a first side, and a second side, the rear portion located opposite the front portion, and the first side located opposite the second side, wherein the pushing surface and the protrusion are located on the first side of the cover and,
wherein the pushing surface and the protrusion are positioned with respect to each other such that the protrusion is located closer to the hinge than the pushing surface to facilitate rotation of the cover with respect to the cap.

US Pat. No. 10,335,343

METHOD AND DEVICE FOR TREATING FEMALE PELVIC NERVE DYSFUNCTION

ParaPatch, Inc., Campbel...

1. A device adapted for providing an inhibitory effect on a bladder of a female person, comprising a patch having a substantially planar skin-contacting surface and sized and configured to be secured directly over and covering a clitoris without covering a urethra of said person, the patch formed of a backing sheet of flexible material with an adhesive layer comprising an adhesive on one side of the backing sheet, the adhesive layer removably connected to a release layer, the patch configured when applied to stimulate the clitoris to inhibit bladder discharge.

US Pat. No. 10,335,342

METHOD, SYSTEM, AND APPARATUS FOR TREATMENT OF BINOCULAR DYSFUNCTIONS

New Jersey Institute of T...

1. A method for remediating visual symptoms in a user with binocular dysfunction, the method comprising:rendering a visual therapy video game on one or more displays;
controlling accommodative and proximal vergence stimulation of a user's eyes via the visual therapy video game; and
asymmetrical stimulating to a left eye or a right eye of the user via the visual therapy video game based on peak velocity differences between the left and right eyes.

US Pat. No. 10,335,341

WALKING ASSISTANCE METHOD AND APPARATUS

Samsung Electronics Co., ...

1. A control device configured to control a vibrator including at least a first vibrating element and a second vibrating element associated with different portions of a sole of a user, the control device comprising:a gait data receiver configured to,
receive pressure data indicating information on a pressure applied to the sole of the user, and
receive hip joint angle data indicating a hip joint angle of the user;
a gait motion estimator configured to estimate a gait motion of the user based on the pressure data; and
a feedback provider configured to,
estimate a center of pressure (COP) of the sole based on the pressure data and the hip joint angle data,
adjust an intensity of a first vibration and a second vibration based on a shift in the COP of the sole with respect to the gait motion such that, during a first step of a stride, the intensity of the first vibration continuously increases and the intensity of the second vibration continuously decreases, and
control the vibrator to vibrate the sole of the user such that the first vibration is applied to the first vibrating element and the second vibration is applied to the second vibrating element.

US Pat. No. 10,335,339

PORTABLE EXAMINATION CHAIR

1. A pivoting examination chair mechanism for an examination chair related to a substantially immovable examination tool, comprising:a rotation mechanism portion rotating about a first vertical axis;
a rotation arm integral with, and extending from, said rotation mechanism portion; and,
a chair support portion attached proximate a distal end of said rotation arm offset from a rotating base portion including a chair gimbal located on a set of legs extending upwards from said rotation arm, wherein said chair gimbal rotates around a second vertical axis and wherein said first vertical axis and said second vertical axis are substantially parallel to one another for moving said rotation arm through 180°, so that said pivoting examination chair is movable about said first vertical axis for providing a clear access area to said substantially immovable examination tool.

US Pat. No. 10,335,337

INCUBATOR WITH THERMOREGULATING ARRANGEMENT FOR NEWBORNS SUFFERING FROM PATHOLOGIES

1. An incubator with a thermoregulating arrangement for newborns suffering from pathologies, comprising a closed compartment which externally has a plurality of openings and an access door, while internally it is comprised of a horizontal partition defining an upper part adapted to receive a newborn in a resting position and a lower part provided with thermoregulating means that produce air flows, adapted to maintain the newborn at required temperatures, said upper part comprises an outer hood separated from an inner hood with an upper external circulation channel being defined therebetween, whereinthe upper external circulation channel being in fluid communication with said lower part through a low pressure lower external circulation channel and a high pressure lower external circulation channel,
the thermoregulating means comprise a heating resistor, a baffle and a cold/heat generator,
said partition is provided with a first head and a second head and at least one mattress tray between both heads,
the first head includes a low pressure internal air channel and the second head includes a high pressure internal air channel, with the low pressure internal air channel and the high pressure internal air channel being arranged at opposite sides of the at least one mattress tray and the thermoregulating means and in fluid communication with opposite ends of the upper part defining an internal air flow flowing from said high pressure internal air channel towards the low pressure internal air channel and extending underneath and concentrically to the inner hood and spaced apart from the at least one mattress tray, thus forming a bubble around the at least one mattress tray.

US Pat. No. 10,335,335

AIR MATTRESS FOR GATCH BED

Paramount Bed Co., Ltd., ...

1. An air mattress placed on a plurality of bottoms including a back bottom, comprising:a plurality of air cells extending to a bed width direction and being arranged in parallel in a bed longitudinal direction;
an air supplying unit for performing supply and discharge of air for each of the air cells; and,
a control unit that inflates and deflates the air cells by increasing and decreasing a pressure of air to be supplied to each of the air cells, wherein
the control unit is configured to:
detect a back tilt angle of the back bottom;
inflate an air cell, of the plurality of air cells, that is in a deflated state when the back tilt angle has reached a first angle; and
perform, after the air cell has been inflated, an inflating and deflating operation of a proper subset of the air cells until a rising operation of the back bottom ends.

US Pat. No. 10,335,334

EMERGENT SITUATION NOTIFICATION DURING TRANSPORT OF A PATIENT SUPPORT APPARATUS

Hill-Rom Services, Inc., ...

1. A patient-support status system comprisinga patient support apparatus adapted to support a patient thereon, the patient support apparatus including control circuitry including memory storing the identity of the patient support apparatus,
a user interface coupled to the control circuitry and monitoring for a user input associated with an emergent situation of the patient during transportation of the patient on the patient support apparatus,
a location-detection system coupled to the control circuitry of the patient support apparatus, the location detection system communicating with location identifiers in a healthcare facility to provide a real-time location of the patient support apparatus as the patient support apparatus moves through the healthcare facility, and
a transceiver coupled to the control circuitry, the transceiver communicating the patient support apparatus identity and the real-time location to a remote computer in response to receipt of the user input.

US Pat. No. 10,335,331

POWERED WHEELCHAIR, WHEELCHAIR POWERING DEVICE AND METHOD

INVENTIT PRODUCTS, INC., ...

1. A wheelchair powering device configured for integration with a foldable wheelchair, the device comprising:an attachment mechanism configured to attach the powering device to the wheelchair;
a motor;
a roller member operatively coupled to the motor such that operation of the motor drives rotation of the roller member; and
an adjustment mechanism operatively coupled to the roller member, the adjustment mechanism being configured to control movement of the roller member into and out of contact with a wheel of the wheelchair,
wherein the adjustment mechanism includes a lever, wherein the roller member passes through a roller member bracket, and wherein the lever is operatively coupled to the roller member bracket such that adjustment of the lever causes rotation of the roller member bracket to displace the roller member,
wherein the wheelchair powering device is configured to provide for the wheelchair to be folded with the wheelchair powering device integrated with the foldable wheelchair, and
wherein, upon integration of the wheelchair powering device with the wheelchair, the wheelchair is configured to be powered interchangeably by both operation by the powering device and manual operation.

US Pat. No. 10,335,329

POWERED COTS

Ferno-Washington, Inc., ...

1. A cot comprising:a support frame comprising a front end, a back end and a pair of parallel lateral side members extending between the front end and the back end, the pair of parallel lateral side members defining tracks therein;
a pair of front legs each of which is slidingly engaged with and pivotally coupled to the support frame through a respective front carriage member that is disposed within one of the tracks, wherein each front leg comprises at least one front wheel;
a pair of back legs each of which is slidingly engaged with and pivotally coupled to the support frame through a respective back carriage member that is disposed within one of the tracks, wherein each back leg comprises at least one back wheel;
a front actuator sensor that detects whether the pair of front legs are in contact with a surface beneath the support frame or the pair of front legs are out of contact with the surface beneath the support frame;
a back actuator sensor that detects whether the pair of back legs are in contact with the surface beneath the support frame or the pair of back legs are out of contact with the surface beneath the support frame; and
a cot actuation system responsive to a received signal from at least one of the front and back actuator sensors during at least one of loading the cot onto or unloading the cot from a loading surface, the cot actuation system comprising a front actuator that is cooperative with each front carriage member to move the at least one wheel of each of the front legs relative to the at least one wheel of each of the back legs during at least one of loading the cot onto or unloading the cot from a loading surface and a back actuator that is cooperative with each back carriage member to move the at least one wheel of each of the back legs relative to the at least one wheel of each of the front legs during at least one of loading the cot onto or unloading the cot from a loading surface.

US Pat. No. 10,335,328

HARNESS SYSTEM FOR PATIENT TRANSPORT APPARATUS

Stryker Corporation, Kal...

1. A patient transport apparatus for transporting a patient, said patient transport apparatus comprising:a support structure having a base and a patient support surface;
wheels coupled to said base;
a harness system operable by a user to secure the patient to said patient support surface, said harness system comprising:
a plurality of harness assemblies configured to be coupled to said support structure, each of said harness assemblies comprising:
a connector; and
a flexible restraint member coupled to said connector, said flexible restraint member comprising a fabric and a coating covering said fabric, said flexible restraint member comprising stitches securing first and second sections of said fabric together at a joint,
wherein said fabric and said stitches are configured to be unexposed to contaminants during use.

US Pat. No. 10,335,327

SPINE BOARD

1. A spine board, comprising: a backboard, wherein at least a portion of the backboard is transparent; and a mirror that is coupled to the backboard via one or more coupling devices, the mirror being substantially the same size as the backboard, the coupling devices facilitating the mirror being at least partially removable from the backboard, and the mirror having a reflective surface facing the backboard when the mirror is coupled to an underside of the backboard, wherein at least partially removing the mirror from the backboard facilitates visual assessment of a posterior surface of a patient occupying the spine board using a reflection, via the mirror, of the posterior surface of the patient through the portion of the backboard that is transparent.

US Pat. No. 10,335,325

ERGONOMIC DISPOSABLE ABSORBENT GARMENT

Advanced Absorbent Techno...

1. A disposable absorbent undergarment configured to be worn by a person, said undergarment having a central longitudinal axis and comprising:an absorbent core assembly centered on said central longitudinal axis and having a pair of sides extending parallel to said central longitudinal axis, said absorbent core assembly being of a predetermined width between said sides, and being configured for absorbing fluid from the person; and
a chassis comprising a sheet of a cloth-like, non-woven, breathable material, said sheet having an inner surface, a front section, a back section, and an crotch section located between said front section and said back section, said front section including a top front edge, a pair of front side edges defining therebetween the width of said front section, and a plurality of linear elastic threads extending parallel to said top front edge and to each other completely across said width of said front section from one of said pair of front side edges to the other of said pair of front side edges, said back section including a top back edge, a pair of back side edges defining therebetween the width of said back section, and a plurality of linear elastic threads extending parallel to said top back edge and to each other completely across said width of said back section from one of said pair of back side edges to the other of said pair of back side edges, said crotch section comprising a pair of central side edges defining therebetween the width of said crotch section, the maximum width of said crotch section being less than said width of said front and back sections, said crotch section having and a plurality of linear elastic threads extending parallel to said front top edge, to said back top edge, and to each other completely across said width of said crotch section from one of said pair of central side edges to the other of said pair of central side edges, respective ones of said front side edges being secured to respective ones of said back side edges, each of said pair of central side sections comprising an ergonomically shaped recess forming a respective leg opening for the person, said recesses being spaced apart from each other by a distance which is greater than said predetermined width of said absorbent core assembly, said absorbent core assembly being secured on said inner surface of said chassis at said crotch section and centered on said central longitudinal axis between said respective leg openings with plural ones of said plurality of linear elastic threads of said crotch section at said absorbent core assembly being cut into a plurality of separated segments extending across the entirety of said absorbent core assembly from a point adjacent one of said pair of sides to a point adjacent the other of said pair of sides whereupon some of said plurality of separated segments extend through said central longitudinal axis and others of said plurality of separated segments are located immediately adjacent said central longitudinal axis, said plurality of separated segments being configured so as not to tend to collapse or buckle said absorbent core assembly when said garment is worn by the person.

US Pat. No. 10,335,324

ABSORBENT ARTICLES WITH CHANNELS

1. An absorbent article comprising:a front waist region;
a rear waist region;
a crotch region positioned intermediate the front waist region and the rear waist region;
a liquid permeable material;
a liquid impermeable material;
an absorbent core disposed at least partially intermediate the liquid permeable material and the liquid impermeable material and comprising an absorbent material, wherein the absorbent material is positioned within a core wrap, wherein the core wrap forms a C-wrap, wherein the absorbent material comprises at least 85% of superabsorbent polymers by weight of the absorbent material, wherein the absorbent core defines a first channel substantially free of the superabsorbent polymers, wherein the first channel extends substantially through the thickness of the absorbent material, wherein a first side of the core wrap is joined to a second side of the core wrap in a portion of the first channel, and wherein the first channel extends from the front waist region to the rear waist region;
a liquid management system positioned at least partially intermediate the liquid permeable material and the core wrap, wherein the liquid management system is substantially free of any superabsorbent polymers; and
a liquid distribution system, wherein the liquid distribution system defines a second channel, wherein the liquid distribution system is positioned intermediate the liquid management system and the core wrap, and wherein the second channel extends substantially through the thickness of the liquid distribution system.

US Pat. No. 10,335,323

METHOD FOR PRODUCING DISPOSABLE WORN ARTICLE

Zuiko Corporation, Osaka...

1. A method for producing a disposable worn article including an around-torso member configured to cover a torso of a wearer and extend in a girth direction and an absorbent body configured to cover a crotch of the wearer, the method comprising the steps of:applying an adhesive on an elastic member extending in a carrying direction;
sandwiching the elastic member between two sheets of continuous non-woven fabric having a pair of side edge portions extending in the carrying direction, and bonding together the two sheets of continuous non-woven fabric along a part of a middle portion between the pair of side edge portions via the adhesive applied on the elastic member so that the two sheets of continuous non-woven fabric are laid on each other, thereby producing a continuous member; and
thermally welding together the two sheets of continuous non-woven fabric along the pair of side edge portions, which are closer to edges of the continuous member than the middle portion bonded by the adhesive, wherein:
the sandwiching step further comprises forming an unbonded central region without adhesive, the central region extending in the carrying direction and dividing the middle portion in two, and
the thermally welding step further comprises thermally welding the two sheets of continuous non-woven fabric together along the central region,
the method further comprises:
a step of cutting and dividing the continuous member, after the thermally welding step, along a virtual cutting line extending in the carrying direction in the central region into a first divided non-woven fabric and a second divided non-woven fabric;
a step of changing a positional relationship between the first and the second divided non-woven fabrics in a width direction perpendicular to the carrying direction by moving the first and the second divided non-woven fabrics relative to each other in the width direction so that the first and the second divided non-woven fabrics are spaced apart from each other in the width direction;
a step of placing absorbent bodies, after the changing step, so that each of the absorbent bodies bridges between the first and the second divided non-woven fabrics and so that each of the absorbent bodies is laid on a portion of the first divided non-woven fabric and on a portion of the second divided non-woven fabric, while the first and the second divided non-woven fabrics are carried in parallel to each other in the carrying direction, thereby producing a continuous laminate; and
a step of cutting the continuous laminate, after the placing step, in the width direction between the absorbent bodies adjacent to each other so that the continuous laminate is cut into an individual disposable worn article, wherein
the step of changing the positional relationship between the first and the second divided non-woven fabrics is carried out by crossing the first and the second divided non-woven fabrics so that the pair of side edge portions are placed between a first cut edge of the first divided non-woven fabric along the cutting line and a second cut edge of the second divided non-woven fabric along the cutting line, thereby the pair of side edge portions being spaced apart from each other while opposing each other in the width direction.

US Pat. No. 10,335,321

BREATHABLE INTERFACE SYSTEM FOR TOPICAL REDUCED PRESSURE

KCI Licensing, Inc., San...

1. A dressing for treating tissue comprising:an elongate applicator having a first end with a first width and a second end having a second width less than a first width, the elongate applicator having an aperture in the first end;
a porous pad;
a fabric layer having a first end located adjacent the aperture between the porous pad and the elongate applicator, the fabric layer extending from the first end to the second end of the elongate applicator;
a drape sealed to the elongate applicator and substantially enclosing the porous pad and the fabric layer; and
wherein the fabric layer has a second end is adapted to receive a reduced pressure from a conduit.

US Pat. No. 10,335,320

REDUCED-PRESSURE DRESSINGS, SYSTEMS, AND METHODS FOR USE WITH LINEAR WOUNDS

KCI Licensing, Inc., San...

1. A dressing assembly for treating a linear wound, comprising:a dressing bolster having a first side and a second, inward-facing side;
a comfort layer having a first side and a second, inward-facing side, the first side of the comfort layer coupled to the second, inward-facing side of the dressing bolster;
a first sealing member covering the dressing bolster;
a second sealing member covering a portion of the second, inward-facing side of the dressing bolster and extending outward from the dressing bolster, wherein a portion of the first sealing member is coupled to the second sealing member by an attachment device; and
a sealing ring disposed on and directly coupled to at least a portion of the second, inward-facing side of the comfort layer.

US Pat. No. 10,335,319

METHOD AND APPARATUS FOR CLEANING ISTHMUS OF EUSTACHIAN TUBE

Acclarent, Inc., Irvine,...

1. A method for cleaning an isthmus of a Eustachian tube (ET) of a patient using an instrument, wherein the instrument comprises a proximal portion, a distal portion, and a shaft extending therebetween, wherein the instrument further comprises a treatment feature disposed at the distal portion, the method comprising:(a) directing the instrument into an oro-nasal cavity of the patient;
(b) advancing at least the distal portion of the instrument into an opening of the ET;
(c) further advancing the instrument within the ET so that the treatment feature is disposed past, or is coincident with, the isthmus; and
(d) moving the treatment feature relative to the isthmus while atraumatically frictionally engaging the isthmus to thereby clean the isthmus by removing debris without damaging the isthmus.

US Pat. No. 10,335,318

LIGHT BLOCKING EYE COVER ATTACHABLE TO A PILLOW

1. An eye covering, comprising in combination:an elongate flexible sleeve having a hollow interior;
said sleeve flexible enough to be configured to wrap around a majority of a head of a wearer and against the head of the wearer;
said sleeve having an elongate form between a proximal end and a distal end;
said distal end and said proximal end free from coupling to other structures; and
said interior at least partially filled with a plurality of individual beads of media.

US Pat. No. 10,335,317

EYEWEAR HAVING MULTIPLE VENTILATION STATES

Oakley, Inc., Foothill R...

1. An assembly for attachment to an eyewear having a lens, the assembly being configured to transition between at least a first configuration and a second configuration, the assembly comprising:a subframe having a nose portion, wherein the subframe is configured to be positioned further apart from the lens in the second configuration than in the first configuration; and
an arm connected to the subframe, the arm configured to move between a first arm position in the first configuration and a second arm position in the second configuration, wherein moving the arm from the first arm position to the second arm position causes the assembly to transition from the first configuration to the second configuration;
wherein the assembly is configured to provide a low ventilation state in the first configuration with the subframe and the lens positioned closer together;
wherein the assembly is configured to provide a high ventilation state in the second configuration with the subframe and the lens positioned further apart from each other;
wherein the high ventilation state is configured to allow more ventilation between an eyewear and the face of the wearer than the low ventilation state.

US Pat. No. 10,335,316

CAPSULAR MEMBRANE TREATMENTS TO INCREASE ACCOMMODATIVE AMPLITUDE

1. An apparatus to treat an eye, the eye having a lens comprising a capsule, the apparatus comprising:a delivery device configured to be coupled to an intermediate portion of the capsule to deliver one or more of an energy or a substance to the intermediate portion of the capsule to stiffen the intermediate portion of the capsule; and
circuitry coupled to the delivery device to deliver the one or more of the energy or the substance to the eye to stiffen the intermediate portion of the capsule.

US Pat. No. 10,335,315

BI-RADIAL PATIENT INTERFACE

ALCON LENSX, INC.

1. A patient interface for an ophthalmic system, comprising:an attachment portion, configured to attach the patient interface to a distal end of the ophthalmic system;
a contact portion, configured for docking the patient interface to an eye; and
a contact element, coupled to the contact portion, comprising a pre-formed shape that includes, prior to contact with a surface of a cornea of the eye as part of the docking of the patient interface to the eye:
a transparent central portion with a central radius of curvature Rc,
a transparent peripheral portion with a peripheral radius of curvature Rp, wherein Rc is smaller than Rp, and
an edge structure where the transparent central portion and the transparent peripheral portion are joined, the edge structure configured to laterally stretch a central-cornea of the eye during the docking, the edge structure having a central diameter Dc in the range of 6-12 mm.

US Pat. No. 10,335,314

DELIVERY SYSTEM AND METHOD OF USE FOR THE EYE

IVANTIS, INC., Irvine, C...

1. An apparatus comprising:an inserter device comprising an interior space and a shaft disposed in the interior space; and
an intraocular implant adapted to self-retain to an inner wall of Schlemm's canal, the intraocular implant being disposed in the interior space of the inserter device, the intraocular implant comprising:
a proximal portion sized and shaped to reside within an anterior chamber of the eye, the proximal portion comprising a proximal opening;
a distal portion sized and shaped to reside within Schlemm's canal of the eye, the distal portion comprising a distal opening and a surface facing the proximal opening and configured to engage an inner wall of Schlemm's canal; and
a passageway extending in a straight line from the proximal opening to the distal opening to conduct fluid from the anterior chamber to Schlemm's canal,
the shaft being adapted to advance the intraocular implant out of the interior space and through an inner wall of Schlemm's canal.

US Pat. No. 10,335,313

METHOD FOR REMOVING COLORED SPOTS TO WHITEN THE EYE

1. A method for whitening an eye by removing pigmented lesions, nevi, and colored spots from the conjunctiva of the eye, comprising the steps of:topically applying an anesthetic to the eye;
preparing the ocular surface with a disinfectant;
inserting an eyelid speculum;
selecting an area of the conjunctiva to be removed, including a colored portion;
selecting and activating a motorized conjunctiva remover, which includes a body and an eye attachment with a tip, and which has a long axis along the length of the conjunctiva remover;
applying the tip of the eye attachment to the selected area of the conjunctiva to continuously wear away the conjunctiva until it is cleared of the colored portion;
deactivating the conjunctiva remover;
removing the eyelid speculum; and,
topically administering an antibiotic substance and an anti-inflammatory substance.

US Pat. No. 10,335,312

VAGINAL RING REMOVAL DEVICE AND METHODS

1. A device for removing an intravaginal drug delivery ring, the device comprising:an integral one-piece finger cot and a substantially rigid hook configured to remove said ring without injuring a vaginal cavity;
wherein said finger cot includes a finger opening, a closed end, a compression band, and an expandable sleeve;
wherein said hook extends away from said finger cot in a first direction and towards said finger cot in a second direction; and
wherein a distal end of said hook is aligned substantially parallel to a central axis of said finger opening and at an angle offset from said central axis.

US Pat. No. 10,335,311

ANTI-SNORING DEVICE

1. An anti-snoring device comprising:an elastic sheet including a first side, a second side, and an aperture, the second side including a first adhesive portion and a second adhesive portion; and
a tube including a first end, a second end, and a hollow interior, the first end of the tube disposed through the aperture of the elastic sheet, wherein the first end of the tube is coupled to the elastic sheet, such that the first end of the tube terminates at the first side of the elastic sheet and the second end of the tube extends a predetermined distance from the second side of the elastic sheet,
wherein, the second side of the elastic sheet is configured to be coupled to a user's face such that the first adhesive portion adheres to skin of the user below the user's nose and above the user's upper lip, the second adhesive portion adheres to the skin of the user below the user's lower lip, and the second end of the tube extends between the user's upper lip and lower lip into the interior of the user's mouth, the predetermined distance selected such that a portion of the upper lip is parted from a portion of the lower lip and the portion of the upper lip and the portion of the lower lip are prevented from touching while the second end of the tube is disposed in the interior of the user's mouth,
wherein, when the second side of the elastic sheet is coupled to the user's face, the elastic sheet is configured to draw the user's lower jaw toward the user's upper jaw to prevent the user from snoring while sleeping and the tube is configured with a predetermined outer circumference that enables the user's upper and lower lips to achieve a substantially closed position around the outer circumference of the tube and enables the user to breathe via the hollow interior of the tube.

US Pat. No. 10,335,310

APPARATUSES AND METHODS FOR DISRUPTING AND PREVENTING SNORE

1. An apparatus for disrupting or preventing snoring, the apparatus comprising:a bladder assembly comprising a sleeve assembly and an inflatable bladder configured to be received within the sleeve assembly, wherein the sleeve assembly comprises a plurality of rigid segments, each rigid segment being pivotally hinged to an adjacent rigid segment;
the inflatable bladder configured to:
inflate to expand the plurality of rigid segments outwardly along a longitudinal axis of the bladder assembly to raise an entire top surface of the bladder assembly substantially in parallel; and
deflate to lower the entire top surface of the bladder assembly substantially in parallel;
wherein a total time of inflation and deflation comprises one inflation cycle;
a conduit connecting the inflatable bladder to an air inflator, the air inflator for inflating the inflatable bladder;
a controller in communication with the air inflator, the controller configured to actuate the air inflator;
suspension components to suspend the air inflator inside a soundproof housing; and
an audio processor in communication with the controller, the audio processor being configured to detect sound waves including a snoring sound, and transmit control commands to the controller to actuate the air inflator to initiate the one inflation cycle once a trigger event is detected.