US Pat. No. 10,213,420

COMBINATION THERAPY FOR TREATMENT OF HBV INFECTIONS

NOVIRA THERAPEUTICS, INC....

1. A method of treating an HBV infection in a subject in need thereof, comprising administering to the subject a capsid assembly inhibitor and interferon, wherein the capsid assembly inhibitor is a compound of Formula IVc:
or a pharmaceutically acceptable salt thereof;
wherein
X is halo;
G1 is hydrogen or halo;
G2 is H, C1-C4 alkyl, or halo; and
G4 is H, halo, C1-C4 alkyl, or OH.

US Pat. No. 10,213,419

COMPOUND IMPURITIES AND METHODS OF DETECTING SAME

Aegerion Pharmaceuticals,...

1. A lomitapide product having the following structure:

US Pat. No. 10,213,417

FATTY ACIDS AS ANTI-INFLAMMATORY AGENTS

1. A method of treating an inflammatory condition comprising administering to the subject in need thereof a formulation comprising a therapeutically effective amount of a compound having the formula:
wherein:
R1 is a heterocyclyl;
is an optional double bond;
W is —OH, —C(O)H, —C(O), —C(O)Rp, —COOH, —COORp, —Cl, —Br, —I, —CF3, —CN, —SO3, —SO2Rp, —SO3H, —NH3+, —NH2Rp+, —NRpRqRt, —NO2, ?O, ?NRp, ?CF2, or —CHF;
each V is, independently —CH or —C—, wherein:
V is —CH— when W is —OH, —H, —C(O)H, —C(O), —C(O)Rp, —COOH, —COORp, —Cl, —Br, —I, —F, —CF3, —CN, —SO3, —SO2Rp, —SO3H, —NH3+, —NH2Rp+, —NRpRqRt or —NO2; or
V is —C— when W is ?O, ?NRp, ?CF2 or ?CHF;
Rp and Rq are each, independently, H, (C1-C8) alkyl, aryl, or (C1-C8) haloalkyl;
Rt is (C1-C8) alkyl, aryl, or (C1-C8) haloalkyl;
Rb and Rb? are each independently, —H, —OH, —C(O)H, —C(O), —C(O)Rp, —COOH, —COORp, —Cl, —Br, —I, —F, —CF3, —CHF2, —CH2F, —CN, —SO3, —SO2Rp, SO3H, —NH3+, —NH2Rp+, —NRpRqRt or —NO2, wherein:
Rb and Rb? are not simultaneously non-hydrogen groups;
a is an integer between 5 and 15 inclusive, c is an integer from 1 and 15 inclusive, and f is an integer between 5 and 15 inclusive; and
a pharmaceutically acceptable carrier.

US Pat. No. 10,213,416

SUBSTITUTED BENZOXAZOLONE DERIVATIVES AS ACID CERAMIDASE INHIBITORS, AND THEIR USE AS MEDICAMENTS

The Regents of the Univer...

1. A compound of Formula (I) or a pharmaceutically acceptable salt thereof
wherein:
X is a bond, CO, CH(OH) or CH2 group; wherein X can be attached to any position of the ring to which it is connected;
R, R1 and R2 are independently hydrogen or linear or branched C1-6 alkyl;
n is an integer from 1 to 6;
A is a linear or branched C1-9 alkyl, C2-9 alkenyl or C2-9 alkynyl group or a group:

wherein:
m is 0 or an integer from 1 to 6;
G is a 3-10 membered saturated or unsaturated, aromatic or heteroaromatic, single or fused ring comprising up to three heteroatoms selected from N, O, and S; and R6 and R7 are as defined below;
R3 is hydrogen, halogen, linear or branched C1-6 alkyl, C1-6 alkoxy or OH; wherein R3 can be attached to any position of the ring to which it is connected;
R4 and R5 are independently selected from the group consisting of hydrogen, halogen, linear or branched C1-6 alkyl, C1-6 alkoxy, hydroxy C1-6 alkyl, OH, CN, NO2, fluoro C1-6 alkyl, fluoro C1-6 alkoxy, COOR8, CONR9R10, SO2NR9R10, and SO2R11;
R6 and R7 are independently selected from the group consisting of hydrogen, halogen, linear or branched C1-6 alkyl, optionally substituted C3-6 cycloalkyl, C1-6 alkoxy, hydroxy C1-6 alkyl, OH, CN, NO2, fluoro C1-6 alkyl, fluoro C1-6 alkoxy, optionally substituted aryl or heteroaryl, COOR8, CONR9R10, SO2NR9R10, and SO2R11;
wherein
R4, R5, R6 and R7 can be attached to any position of the ring to which they are connected;
Y is a bond or a heteroatom selected from the group consisting of O, S, SO, SO2 and NR12; and
R8, R9, R10, R11 and R12 are independently selected from the group consisting of hydrogen and linear or branched C1-6 alkyl;
with the proviso that when Y is a bond, n+m is ?4 and A is a group

US Pat. No. 10,213,415

COMPOUNDS AS OPIOID RECEPTOR MODULATORS

Janssen Pharmaceutica NV,...

1. A method for treating visceral pain in a subject in need thereof comprising administering to the subject a therapeutically effective amount of a compound having the structure:
or a pharmaceutically acceptable salt thereof.

US Pat. No. 10,213,414

GLUCOCORTICOID RECEPTOR MODULATORS TO TREAT PANCREATIC CANCER

Corcept Therapeutics, Inc...

1. A method of treating a subject hosting a non-ACTH-secreting pancreatic tumor, the method comprising administering to the subject an effective amount of a chemotherapeutic agent and orally administering an effective amount of a nonsteroidal selective glucocorticoid receptor modulator to reduce the tumor load of the pancreatic tumor, wherein the nonsteroidal selective glucocorticoid receptor modulator is a compound comprising a fused azadecalin structure having the formula:whereinL1 and L2 are members independently selected from a bond and unsubstituted alkylene;
R1 is a member selected from unsubstituted alkyl, unsubstituted heteroalkyl, unsubstituted heterocycloalkyl, —OR1A, NR1CR1D, —C(O)NR1CR1D, and —C(O)OR1A, wherein
R1A is a member selected from hydrogen, unsubstituted alkyl and unsubstituted heteroalkyl,
R1C and R1D are members independently selected from unsubstituted alkyl and unsubstituted heteroalkyl,
wherein R1C and R1D are optionally joined to form an unsubstituted ring with the nitrogen to which they are attached, wherein said ring optionally comprises an additional ring nitrogen;
R2 has the formula:

wherein
R2G is a member selected from hydrogen, halogen, unsubstituted alkyl, unsubstituted heteroalkyl, unsubstituted cycloalkyl, unsubstituted heterocycloalkyl, —CN, and —CF3;
J is phenyl;
t is an integer from 0 to 5;
X is —S(O2)—; and
R5 is phenyl optionally substituted with 1-5 R5A groups, wherein
R5A is a member selected from hydrogen, halogen, —OR5A1, S(O2)NR5A2R5A3, —CN, and unsubstituted alkyl, wherein
R5A1 is a member selected from hydrogen and unsubstituted alkyl, and
R5A2 and R5A3 are members independently selected from hydrogen and unsubstituted alkyl,
or salts and isomers thereof.

US Pat. No. 10,213,413

ANTIVIRAL AGENTS DIRECTED AGAINST RESPIRATORY SYNCYTIAL VIRUS

CENTRE NATIONAL DE LA REC...

1. A method for treating an infection by respiratory syncytial virus (RSV), comprising administering to a subject an agent, wherein said agent is represented in formula (I):wherein :R1 and R2 are identical or different and are independently chosen among hydrogen, hydroxyl, halogen, haloalkyl, alkyl, aryl, arylalkyl, nitro, cyano, amino, alkoxy, alkoxyalkyl, heteroaryl, cycloalkyl and heterocyclyl; and
R3 and R4 are identical or different and are independently chosen among carboxylate, ester, substituted or non-substituted alkyloxycarbonyl, halogen, haloalkyl, alkyl, aryl, arylalkyl, nitro, cyano, amino, alkoxy, alkoxyalkyl, heteroaryl, cycloalkyl, heterocyclyl, boronate, phosphate, phosphonate, sulfinyl, sulfonyl, sulfonate, and sulfonamino, sulfonamido.

US Pat. No. 10,213,412

MODULATORS OF CA2+ RELEASE-ACTIVATED CA2+ (CRAC) CHANNELS AND PHARMACEUTICAL USES THEREOF

VIVREON BIOSCIENCES, LLC,...

1. A compound having the structure of Formula (I), or a pharmaceutically acceptable salt or solvate thereof:
wherein,
each R1 is independently H, halogen, C1-C6alkyl, C1-C6fluoroalkyl, C1-C6deuteroalkyl, C3-C6cycloalkyl, C1-C6hydroxyalkyl, or C1-C6heteroalkyl;
R2 is C1-C6alkoxy or hydroxy;
R3 is C1-C6alkoxy or hydroxy;
or R2 and R3 are taken together with the carbon atom to which they are attached to form —C(?O)—, —C(?NR13)—, —C(?N—OR13)—, or a heterocyclic ring containing 2 O atoms;
R13 is H or C1-C6alkyl;
R4 is H, halogen, C1-C6alkyl, C1-C6fluoroalkyl, or C1-C6deuteroalkyl;
R5 is H, halogen, C1-C6alkyl, C1-C6fluoroalkyl, or C1-C6deuteroalkyl;
or R4 and R5 are taken together with the carbon atom to which they are attached to form a substituted or unsubstituted C3-C6cycloalkyl ring, or a substituted or unsubstituted C3-C6heterocyclic ring containing 1 or 2 heteroatoms selected from —O—, —NR12— and —S—;
R6 is H, halogen, C1-C6alkyl, C1-C6fluoroalkyl, or C1-C6deuteroalkyl;
R7 is H, halogen, C1-C6alkyl, C1-C6fluoroalkyl, or C1-C6deuteroalkyl;
or R6 and R7 are taken together with the carbon atom to which they are attached to form a substituted or unsubstituted C3-C6cycloalkyl ring, or a substituted or unsubstituted C3-C6heterocyclic ring containing 1 or 2 heteroatoms selected from —O—, —NR12— and —S—;
R8 is halogen, C1-C6alkyl, C1-C6fluoroalkyl, C1-C6deuteroalkyl, C1-C6cycloalkyl, C1-C6hydroxyalkyl, C1-C6heteroalkyl, —CN, —NO2, —OH, —OR11, —SR11, —S(?O)R11, —S(?O)2R11, —S(?O)2N(R12)2, —NR12S(?O)2R11, —C(?O)R11, —OC(?O)R11, —CO2R12, —OCO2R11, —N(R12)2, —C(?O)N(R12)2, —OC(?O)N(R12)2, —NHC(?O)R11, or —NHC(?O)OR11;
R9 is halogen, C1-C6alkyl, C1-C6fluoroalkyl, C1-C6deuteroalkyl, C1-C6cycloalkyl, C1-C6hydroxyalkyl, C1-C6heteroalkyl, —CN, —NO2, —OH, —OR11, —SR11, —S(?O)R11, —S(?O)2R11, —S(?O)2N(R12)2, —NR12S(?O)2R11, —C(?O)R11, —OC(?O)R11, —CO2R12, —OCO2R11, —N(R12)2, —C(?O)N(R12)2, —OC(?O)N(R12)2, —NHC(?O)R11, or —NHC(?O)OR11;
each R10 is independently H, halogen, C1-C6alkyl, C1-C6fluoroalkyl, C1-C6deuteroalkyl, C1-C6cycloalkyl, C1-C6hydroxyalkyl, C1-C6heteroalkyl, —CN, —NO2, —OH, —OR11, —SR11, —S(?O)R11, —S(?O)2R11, —S(?O)2N(R12)2, —NR12S(?O)2R11, —C(?O)R11, —OC(?O)R11, —CO2R12, —OCO2R11, —N(R12)2, —C(?O)N(R12)2, —OC(?O)N(R12)2, —NHC(?O)R11, or —NHC(?O)OR11;
each RH is independently C1-C6alkyl, C1-C6fluoroalkyl, C1-C6deuteroalkyl, or C3-C6cycloalkyl;
each R12 is independently H, C1-C6alkyl, C1-C6fluoroalkyl, C1-C6deuteroalkyl, or C3-C6cycloalkyl;
n is 0, 1, 2, or 3; and
m is 0, 1, 2, or 3.

US Pat. No. 10,213,409

SUBSTITUTED BENZOFURANS, BENZOTHIOPHENES, BENZOSELENOPHENES AND INDOLES AND THEIR USE AS TUBULIN POLYMERISATION INHIBITORS

BIONOMICS LIMITED, Theba...

1. A combination comprising a compound of formula (I)or a salt thereof, whereinX represents O, S, SO, SO2, Se, SeO, SeO2 or NR where R is selected from H, O, optionally substituted acyl, optionally substituted alkenyl, optionally substituted alkyl, optionally substituted aryl, optionally substituted cycloalkenyl, optionally substituted cycloalkyl, optionally substituted heteroaryl, optionally substituted heterocyclyl, and optionally substituted sulfonyl;
R1A and R1B each independently represents H, carboxy, cyano, dihalomethoxy, halogen, hydroxy, nitro, pentahaloethyl, phosphorylamino, phosphono, phosphinyl, sulfo, trihaloethenyl, trihalomethanethio, trihalomethoxy, trihalomethyl, optionally substituted acyl, optionally substituted acylamino, optionally substituted acylimino, optionally substituted acyliminoxy, optionally substituted acyloxy, optionally substituted arylalkyl, optionally substituted arylalkoxy, optionally substituted alkenyl, optionally substituted alkenyloxy, optionally substituted alkoxy, optionally substituted alkyl, optionally substituted alkynyl, optionally substituted alkynyloxy, optionally substituted amino, optionally substituted aminoacyl, optionally substituted aminoacyloxy, optionally substituted aminosulfonyl, optionally substituted aminothioacyl, optionally substituted aryl, optionally substituted aryloxy, optionally substituted cycloalkenyl, optionally substituted cycloalkyl, optionally substituted heteroaryl, optionally substituted heterocyclyl, optionally substituted oxyacyl, optionally substituted oxyacylamino, optionally substituted oxyacyloxy, optionally substituted oxyacylimino, optionally substituted oxysulfinylamino, optionally substituted oxysulfonylamino, optionally substituted oxythioacyl, optionally substituted oxythioacyloxy, optionally substituted sulfinyl, optionally substituted sulfinylamino, optionally substituted sulfonyl, optionally substituted sulphonylamino, optionally substituted thio, optionally substituted thioacyl, optionally substituted thioacylamino, or R1A and R1B together form an optionally substituted aryl, optionally substituted heterocyclyl, optionally substituted heteroaryl, optionally substituted cycloalkyl, or optionally substituted cycloalkenyl;
R1C represents C1-3 alkoxy, C1-3 alkylthio, C1-3 alkylamino, or C1-3 dialkylamino;
R1D represents hydroxy, amino, or phosphate ester;
L represents C?O, O, S, SO, SO2, Se, SeO, SeO2, C?NZ?, or NR? where Z? is H, optionally substituted alkyl, optionally substituted aryl or optionally substituted amino; and where R? is selected from H, O, optionally substituted acyl, optionally substituted alkenyl, optionally substituted alkyl, optionally substituted aryl, optionally substituted cycloalkenyl, optionally substituted cycloalkyl, optionally substituted heteroaryl, optionally substituted heterocyclyl, or optionally substituted sulfonyl;
R2A-R2E each independently represents H, carboxy, cyano, dihalomethoxy, halogen, hydroxy, nitro, pentahaloethyl, phosphorylamino, phosphono, phosphinyl, sulfo, trihaloethenyl, trihalomethanethio, trihalomethoxy, trihalomethyl, optionally substituted acyl, optionally substituted acylamino, optionally substituted acylimino, optionally substituted acyliminoxy, optionally substituted acyloxy, optionally substituted arylalkyl, optionally substituted arylalkoxy, optionally substituted alkenyl, optionally substituted alkenyloxy, optionally substituted alkoxy, optionally substituted alkyl, optionally substituted alkynyl, optionally substituted alkynyloxy, optionally substituted amino, optionally substituted aminoacyl, optionally substituted aminoacyloxy, optionally substituted aminosulfonyl, optionally substituted aminothioacyl, optionally substituted aryl, optionally substituted aryloxy, optionally substituted cycloalkenyl, optionally substituted cycloalkyl, optionally substituted heteroaryl, optionally substituted heterocyclyl, optionally substituted oxyacyl, optionally substituted oxyacylamino, optionally substituted oxyacylimino, optionally substituted oxyacyloxy, optionally substituted oxysulfinylamino, optionally substituted oxysulfonylamino, optionally substituted oxythioacyl, optionally substituted oxythioacyloxy, optionally substituted sulfinyl, optionally substituted sulfinylamino, optionally substituted sulfonyl, optionally substituted sulphonylamino, optionally substituted thio, optionally substituted thioacyl, optionally substituted thioacylamino, or optionally substituted thioacyloxy; or any of R2A and R2B, R2B and R2C, R2C and R2D, and R2D and R2E, together form an optionally substituted aryl, optionally substituted heterocyclyl, optionally substituted heteroaryl, optionally substituted cycloalkyl, or optionally substituted cycloalkenyl; and
Q represents C1-4 alkyl,and,at least one further compound that is cytotoxic.

US Pat. No. 10,213,408

NITROXYL DONORS WITH IMPROVED THERAPEUTIC INDEX

Cardioxyl Pharmaceuticals...

2. A method of treating heart failure, comprising intravenously administering an effective amount of a compound of formula (2), or a pharmaceutical composition comprising the compound of formula (2), to a patient in need thereof, wherein the compound of formula (2) is represented by formula:and wherein the compound or the pharmaceutical composition is administered at a dose of at least 1 ?g/kg/min.

US Pat. No. 10,213,407

COMPOUNDS AND METHODS FOR INHIBITING PRODUCTION OF TRIMETHYLAMINE

THE CLEVELAND CLINIC FOUN...

1. A method of inhibiting the conversion of choline or carnitine to trimethylamine (TMA) by a bacterium comprising: contacting the bacterium with a compound as set forth in Formula (I):
wherein
Y+ is selected from a quaternary nitrogen; X? is an anion; n is selected from 1, 2 or 3; R2 and R3 are independently selected from C1-4 alkyl or bound together forming an aliphatic, aromatic or heterocyclic ring system;
R4 is selected from C1-4 alkyl, alkenyl, alkynyl, alkoxy carbonyl, alkoxy dicarbonyl, acrylic, alkoxy, alkoxy alkyl, aryloxy alkyl, alkyl carboxylate as part of a betaine, inner salt, or Zwitterion form, halo alkyl, hydroxy alkyl, nitrile, or propargyl;
R6 is selected from C1-4 alkyl, alkoxy, hydroxy, alkoxy alkyl, hydroxy alkyl, or epoxy; and
including any acceptable salts or solvates thereof.

US Pat. No. 10,213,406

?- AND ?-TRUXILLIC ACID DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS THEREOF

THE RESEARCH FOUNDATION F...

1. A method of inhibiting the activity of a Fatty Acid Binding Protein (FABP) comprising contacting the FABP with a compound having the structure:
wherein
one of R1 or R2 is —C(?O)R13, —C(?O)OR13, —C(?O)NR13R14, -alkyl-OC(?O)OR13, -alkyl-OC(?O)R13, -alkyl-OR13, -alkyl-NR13R14, -alkyl-NHC(?O)R13, -alkyl-NHC(?O)OR13, -alkyl-NHC(?O)NR13R14, -alkyl-NHC(?S)NR13R14, or -alkyl-NHC(?NR13)NR13R14,
wherein R13 and R14 are each, independently, H, CF3, C1-10 alkyl, C2-10 alkenyl, C2-10 alkynyl, heteroalkyl, cycloalkyl, aryl, heteroaryl, heterocyclyl or combine to form a cycloalkyl or heterocyclyl; and
the other of R1 or R2 is —C(?O)OR13, wherein R13 is H;
R3, R4, R5, R6, R7, R8, R9, R10, R11 and R12 are each independently, H, halogen, —NO2, —CN, —NHR15, —NR15R16, —SR15, —SO2R15, —OR15, —CO2R15, CF3, -alkyl-NHR15, -alkyl-NHR15R16, -alkyl-OR15, C1-10 alkyl, C2-10 alkenyl, C2-10 alkynyl, aryl, heteroaryl, or heterocyclyl,
wherein R15 and R16 are each, independently, H, CF3, C1-10 alkyl, C2-10 alkenyl, C2-10 alkynyl, heteroalkyl, cycloheteroalkyl, aryl, heteroaryl, or heterocyclyl,
or a pharmaceutically acceptable salt thereof.

US Pat. No. 10,213,404

CONTROLLED RELEASE DOSAGE FORM

OSMOTICA KERESKEDELMI ES ...

1. A method of treating a condition, disorder or disease that is therapeutically responsive to (R)-baclofen (ARBAC), the method comprising orally administering to a subject in need thereof at least one controlled release oral dosage form comprising: a) a core ARBAC and at least two water-swellable excipients; and b) a semipermeable membrane surrounding the core, said membrane comprising at least two film-forming cellulose esters and at least one preformed passageway; whereinfollowing oral administration of said dosage form, the dosage form releases a majority of ARBAC downstream of the stomach and upstream of the colon.

US Pat. No. 10,213,403

CONTROLLED RELEASE DOSAGE FORM

OSMOTICA KERESKEDELMI ES ...

1. A method of treating a condition, disorder or disease that is therapeutically responsive to (R)-baclofen (ARBAC), the method comprising orally administering to a subject in need thereof at least one controlled release oral dosage form comprising: a) a core comprising ARBAC, at least one disintegrant, at least one osmotic agent, at least one binder, at least one water swellable cellulose derivative (CD) polymer and at least one water swellable polyalkylene oxide (PAO) polymer, wherein the amount of PAO polymer exceeds the amount of CD polymer; and b) a semipermeable membrane surrounding the core, said membrane comprising at least two different grades of cellulose acetate polymer and at least one preformed passageway; wherein:about 60 to about 100% wt of the drug is released over a period of about 6 to about 16 hours under conditions defined in USP <711> using a Type II apparatus with 0.1 N HCl stirred at 50 rpm and maintained at a temperature of 37±0.5° C.; and
following oral administration to a subject, the dosage form provides a majority of drug release from the core downstream of the stomach and upstream of the colon.

US Pat. No. 10,213,402

CONTROLLED RELEASE DOSAGE FORM

OSMOTICA KERESKEDELMI ES ...

1. A controlled release oral dosage form comprising: a) a core comprising at least one GABAB receptor agonist and at least two water-swellable excipients; and b) a semipermeable membrane surrounding the core, said membrane comprising at least two film-forming cellulose esters; wherein the at least one GABAB receptor agonist is (R)-baclofen (ARBAC); and following oral administration of said dosage form, the dosage form releases a majority of ARBAC downstream of the stomach and upstream of the colon.

US Pat. No. 10,213,401

IMMUNOMODULATORY AND DIFFERENTIATING FUNCTION SELECTIVE RETINOID AND REXINOID COMPOUNDS IN COMBINATION WITH IMMUNE MODULATORS FOR CANCER IMMUNOTHERAPY

Io Therapeutics, Inc., S...

1. A method of potentiating chimeric antigen receptor-modified immune cells (CAR-MIC) cancer immunotherapy comprising administering an immunomodulatory retinoid active agent and/or rexinoid active agent (RAR/RXR active agent), and a differentiating RAR active agent to a cancer patient who is receiving, has received, or is scheduled to receive, CAR-MIC, wherein the immunomodulatory RAR/RXR active agent is:a) a RAR? antagonist, wherein the RAR? antagonist is:
i) a compound of general formula (I)

wherein R1, R2, R3, and R6 are independently H or C1-6 alkyl; R4 and R5 are independently H or F; Ar is phenyl, pyridyl, thienyl, furyl, or naphthyl; X is C(CH3)2, O, S, or NR7, wherein R7 is H or C1-6 alkyl; X1 is H or halogen such as F, Cl or Br; and R8 is H or OH; or
ii) a compound of general formula (II)

wherein R1 and R2 are independently C1-6 alkyl; X is O, S, or CH2; Y is O, S, CH2, or NR3, wherein R3 is C1-6 alkyl; Z is Cl or Br; W is H or OH; and U is independently H or F; or
iii) a compound of general formula (III):

wherein R1 and R2 are independently H or C1-6 alkyl; R3 is H or F; Ar is phenyl, pyridyl, thienyl, furyl, or naphthyl; X is O, S, N, or CH2; W is H or OH; and Z is Cl or Br; or
iv) BMS185411, BMS614, Ro41-5253, Ro46-5471, or AGN 194777; or
b) a RAR? agonist, wherein the RAR? agonist is:
i) a compound of general formula (IV):

wherein R1 and R2 are independently H or C1-6 alkyl; R3 is H or F; and X is O, S, CH2, C(R4)2, or NR5, wherein R4 and R5 are independently H or C1-6 alkyl; or
oriii) CD437, CD2325, CD666, or BMS961; or
c) a RXR antagonist, wherein the RXR antagonist is:
AGN195393, LGN100849,
ord) a combination thereof; andwherein the differentiating RAR active agent is a RAR? agonist, wherein the RAR? agonist is a compound of general formula (V):
wherein R1 is H or C1-6 alky, R2 and R3 are independently H or F, and R4 is a halogen.

US Pat. No. 10,213,395

TOXIC ALDEHYDE RELATED DISEASES AND TREATMENT

Aldeyra Therapeutics, Inc...

1. A method of treating uveitis, comprising:administering to a subject with uveitis a therapeutically effective amount of a compound of formula (I):
or a pharmaceutically acceptable salt thereof, wherein,X is CH; Z is N; and Y is C with the —NH2 attached;
p is 0, 1, 2, or 3;
each RB is independently a halogen, hydroxyl, carbamoyl, amino, or aryl;
RA is
andeach Qa is independently a C1-C6 straight chain alkyl.

US Pat. No. 10,213,392

PHARMACEUTICAL COMPOSITION FOR USE IN MEDICAL AND VETERINARY OPHTHALMOLOGY

MITOTECH SA, Luxembourg ...

1. A method of treating an eye pathology, comprising administering to a subject afflicted with such an eye pathology a therapeutically-effective amount of a pharmaceutical composition comprising:(a) from 1 nm to 25000 nm of a mitochondria-addressed antioxidant comprising:

(b) from 0.01% to 0.2% of a lipophilic, cationic concentration stabilizer that stabilizes a concentration of the mitochondria-addressed antioxidant by preventing reversible and irreversible absorption of the antioxidant to walls of a vial containing the pharmaceutical composition, the stabilizer comprising a benzalkonium salt, berberine, palmatine, tetraphenylphosphonium, tetrabutyl ammonium, or combinations thereof; and
(c) from 0.001% to 1% of a prolongator comprising a disaccharide, a trisaccharide, a polysaccharide, methylcellulose, hydroxyethylcellulose, hydroxypropyl-methyl cellulose, carboxymethylcellulose, sodium chondroitin sulfate, sodium hyaluronate, carboxyvinyl polymer, polyvinyl ethanol, polyvinylpyrrolidone, macrogol, or combinations thereof.

US Pat. No. 10,213,385

COMBINATIONAL LIPOSOME COMPOSITIONS FOR CANCER THERAPY

MALLINCKRODT LLC, Hazelw...

1. A first composition comprising a first liposome comprising a therapeutic agent, wherein the therapeutic agent is selected from the group consisting of: cisplatin, oxaliplatin, carboplatin, gemcitibine, 5-fluorouracil, doxorubicin, and a taxane; anda second composition comprising a lipid nanoparticle comprising a non-ionic triggering agent for sequential or concurrent use with the first composition in delivering a therapeutic agent to a subject in need thereof,
whereby release of the therapeutic agent from the liposome following administration of the lipid nanoparticle is increased, relative to the release of the therapeutic agent from the liposome without administration of the lipid nanoparticle.

US Pat. No. 10,213,384

FOAMABLE VEHICLES AND PHARMACEUTICAL COMPOSITIONS COMPRISING APROTIC POLAR SOLVENTS AND USES THEREOF

Foamix Pharmaceuticals Lt...

1. A non-aqueous composition formulated for skin delivery of an active agent comprising:a minocycline in a therapeutically effective amount of about 1% to about 5% by weight of the composition;
a short chain alcohol comprising ethanol present in an amount of at least 55% by weight of the composition;
about 12% to about 50% by weight of the composition of a protic polar solvent comprising propylene glycol;
a polymeric agent comprising a cellulose ether, wherein the cellulose ether is a hydroxypropyl cellulose present in an amount ranging from about 0.5% to about 1% by weight of the composition;
a modulating agent comprising an antioxidizing agent present in an amount ranging from about 0.1% to about 10% by weight of the composition;
a metal; and
an essential oil,
wherein the composition is surfactant free, non-aqueous, and free or essentially free of fatty alcohol.

US Pat. No. 10,213,382

NANOSUSPENSION OF NATURAL MATERIALS AND PREPARATION METHOD THEREOF

APURANO PHARMACEUTICALS G...

1. A method for the preparation of a nanosuspension, the method comprising:dispersing at least one natural material having a particle size (D100) of less than 320 ?m in a solvent, thereby obtaining a dispersion; and
milling the dispersion to a particle size (D90) of below 500 nm,
wherein the nanosuspension comprises the at least one natural material,
wherein the at least one natural material is at least one selected from the group consisting of plants, cyanobacteria, algae and fungi, and
wherein the at least one natural material is not an extract.

US Pat. No. 10,213,377

TOPICAL SKIN COMPOSITIONS FOR TREATING WRINKLES

Mary Kay Inc., Addison, ...

1. A method of stimulating adipogenesis in a person's skin, the method comprising topically applying to skin in need thereof, a composition comprising an effective amount of Commiphora mukul resin or an extract thereof that includes oleo gum resin, wherein adipogenesis in the person's skin is stimulated.

US Pat. No. 10,213,371

STABLE COSMETIC PREPARATION WITH A HIGH PIGMENT CONTENT

BEIERSDORF AG, Hamburg (...

1. A cosmetic preparation, wherein the preparation is present as an emulsion and comprises, based on a total weight of the preparation:(a) at least 4% by weight of a compound of formula (I):

(b) at least 20% by weight of (i) titanium dioxide having a surface coating consisting of one or more of sodium hexametaphosphate, sodium metaphosphate, iron oxide, aluminum stearate, stearic acid, lauric acid, dimethicone, methicone, methylhydrogenpolysiloxane, octyltrimethylsilane, triethoxycapryl silane, and/or of (ii) zinc oxide having a surface coating consisting of one or both of dimethicone and methicone.

US Pat. No. 10,213,367

DENTAL MATERIALS WITH DEBONDING-ON-DEMAND PROPERTIES

Ivoclar Vivadent AG, Sch...

1. Radically polymerizable dental material which contains at least one compound of Formula I:
with:
A=H; —CN; a phenyl residue which can carry one or more substituents; or an aliphatic linear or branched C1-C20 alkylene residue which can be interrupted by one or more 1,4-phenylene groups, urethane groups, O or S and which can carry in the terminal position a polymerizable vinyl, (meth)acryloyloxy or (meth)acrylamide group;
R1=H, an aliphatic linear or branched C1-C9 alkyl radical, tolyl or phenyl;
L=SO2R3, wherein R3 is CH3 or tolyl;
X=—COO—, —CON(R10)— or is absent, wherein the bond to A takes place via O or N and
R10=H; or is an aliphatic linear or branched C1-C20 alkylene residue which can be interrupted by one or more O or S and which can carry in the terminal position a polymerizable vinyl, (meth)acryloyloxy, (meth)acrylamide group, —C(?CH2)—COOR11 or —C(?CH2)—CO—NR12R13, wherein R11-13 in each case independently of each other are a linear or branched C1-6 residue;
n=an integer from 1 to 6,
and at least one thermolabile radically polymerizable compound and/or at least one photolabile radically polymerizable compound.

US Pat. No. 10,213,366

PACIFIER ASSEMBLY COMPRISING OUTER CONTAINER, WRISTBAND, AND TETHER

TWL, LLC, Richland, NC (...

1. An assembly comprising:a container defining a cavity for housing a bulbous portion of a pacifier;
a tether for coupling the container to a ring, the ring selectively engageable with the pacifier;
a spool housed within the container for retracting the pacifier into a stored position from an extended position, wherein the bulbous portion is housed within the cavity in the stored position and is a distance from the cavity in the extended position; and
the ring and the container each including at least one magnet for selectively engaging the ring to the container and positioning the pacifier within the cavity when the ring is engaged with the pacifier and the pacifier is retracted by the spool.

US Pat. No. 10,213,365

DOSE INDICATION DEVICE

1. A dose indicator device for attachment to a container cap on a container, comprising:a. a base disk having a first upper surface and a second lower surface where in the first upper surface includes a center mount axle extending from center of the first upper surface of the base disk, wherein the center mount axle includes a shaft and a head and wherein a circumference of the head is larger than a circumference of the shaft, wherein the first upper surface supports an overlay plate with a center-spaced opening placed over the base disk such that the opening is placed over the center mount axle, wherein the overlay plate displays dose indicia for indicating time and the second lower surface of the base disk contains an adhesive, magnet base, or hook-and-loop fastener material which allows the base disk to be attached to a surface;
b. a reminder dial rotatably positioned at the center of the base disk by means of the center mount axle and extending outwardly toward the dose indicia for indicating time; and
c. a second pointer directly attached to the base disk for designating a second date/time of interest.

US Pat. No. 10,213,364

DELIVERY VEHICLE FOR DELIVERING BIOLOGICAL PRODUCTS TO A SURGICAL SITE AND METHODS THEREOF

HOSPITAL FOR SPECIAL SURG...

1. A delivery vehicle for delivering biological products to a surgical site comprising:a sterile flexible porous film container for housing a biological product, the sterile flexible porous film container having:
an access that is moveable between an open position and a closed position,
a first compartment in fluid communication with the access, and
a second compartment in fluid communication with the access;
a filter covering the access; and
a fastener for securing the sterile flexible porous film container adjacent to the surgical site,
wherein the sterile flexible porous film container is moveable between open and closed positions via the fastener.

US Pat. No. 10,213,363

ACUPUNCTURE NEEDLES WITH ACCESSORIES FOR SENSING AND STIMULATION

Acumedical, Inc., North ...

1. An apparatus configured to provide an interface between a medical device and a person having skin and tissue under the skin, the apparatus comprising:an acupuncture needle configured to be connected to the medical device, the acupuncture needle including:
a handle; and
a needle body coupled to the handle, the needle body including a proximal end portion connected to the handle, a distal end portion including a needle tip suitable for piercing the skin and the tissue, and an elongate body shaft coupled between the proximal end portion and the distal end portion; and
a guiding tube configured to assist percutaneous insertion of a substantial portion of the needle body into the tissue, the guiding tube including:
an elongate tube of electrically non-conductive material, the elongate tube including a proximal end including a proximal opening, a distal end including a distal opening for contacting the skin and a lumen between the proximal opening and the distal opening, the lumen configured to allow the needle tip to enter the proximal opening and exit from the distal opening;
an electrode incorporated into the distal end of the elongate tube; and
a connector configured to allow for electrical connection between the electrode and the medical device.

US Pat. No. 10,213,362

PORTABLE HYDRO-THERMAL THERAPY SYSTEM FOR USE WITH A VESSEL FOR CONTAINING WATER AND METHOD FOR USE OF SAME

Hobson A. Howell, Woodwa...

1. A portable hydro-thermal therapy kit, comprising:a vessel having an open top, the vessel being an open water tank source for a cool water supply water device having water;
a portable hydro-thermal therapy system comprising:
a mobile trailer having a platform, the mobile trailer including four wheels and a handle mounted to the platform, the mobile trailer physically configured for an individual to achieve point-to-point haulage thereof;
the mobile trailer having a design weight of about 200 pounds;
the cool water supply device mounted on the platform, the cool water supply device having an inlet port and an outlet port, the cool water supply device including:
a closed water circulation path within the cool water supply device defining a path from the inlet port to the outlet port with the open water tank source consisting of a water source,
a thermometer monitoring the temperature of water pumping into the inlet port, and the thermometer monitoring the temperature of water pumping from the outlet port,
a water pump coupled to the closed water circulation path, the water pump for pumping water from the inlet port to the outlet port,
a refrigeration cycle contained within the cool water supply device, the refrigeration cycle including a refrigerant circulating through a condensing coil, an expansion valve, a evaporator coil, and a compressor under the thermal control of a thermostat in communication with the thermometer, and
the closed water circulation path including a water thermal exchange chamber interposed between the inlet port and outlet port, the water thermal exchange chamber being thermally proximate to the evaporator coil,
the thermostat and water pump cooperating in combination to provide water between about 50° F. and about 55° F.;
a flow restrictor secured to an outlet tubing to regulate the back pressure in order to ensure proper pressure is maintained,
the closed water circulation path being thermally proximate to the evaporator coil in order to cool the water being pumped through the water circulation path;
inlet tubing coupled to the inlet port, the cool water supply device configured to pump water out of the vessel through the inlet tubing as the sole source of water to the cool water supply device;
the cool water supply device having a design with flow of about seven gallons/minute with an about 300 gallons cooling capacity;
the outlet tubing coupled to the outlet port, the cool water supply device configured to pump water into the vessel through the outlet tubing; and
a controller located within the cool water supply device in communication with the closed water circulation path and the refrigeration cycle, the controller including memory, which is accessible to a processor, the memory includes processor-executable instructions that, when executed cause the processor to execute instructions for measuring temperature via the thermometer, selectively activating the water pump, and selectively activating the refrigeration cycle to achieve a change in temperature of the water flowing through the closed water circulation path based on matching the desired temperature with the rate of flow and refrigeration cooling coefficient in view of the constant pressure maintained by the flow restriction.

US Pat. No. 10,213,361

MUSCLE FIBER EXCITATION SYSTEM FOR PREVENTING BLOOD CLOT AND MUSCULAR-SKELETAL DECLINE

1. A muscle fiber excitation system (WES) for use in stimulating circulation to ameliorate formation of a blood clot and to prevent muscular-skeletal decline in a patient, the system comprising:a) an enclosure comprising a base and two pillar blocks, wherein the pillar blocks each comprise a first and a second channel, the first and the second channel comprising bearings, the pillar blocks being parallel to each other such that the first channel on the first pillar block is aligned with the first channel on the second parallel pillar block and the second channel on the first pillar block is aligned with the second channel on the second parallel pillar block;
b) a first and a second shaft, each shaft affixed with two cams, wherein the first shaft is mounted in the first channels of the first and second pillar block and the second shaft is mounted in the second channels of the first and second pillar block, the first and second shafts being rotatably mounted off the enclosure base in the bearings in the channels of the pillar blocks;
c) a direct current motor mounted within the enclosure, the direct current motor being operably linked to a power source, and being configured to drive at least one timing belt, wherein the at least one timing belt is coupled to the first and the second shaft such that operation of the direct current motor drives the timing belt and thereby rotates the first and the second shafts;
d) four plungers, each plunger being positioned at a corner of the enclosure; and
e) a telescoping platform configured to be mounted on the enclosure, the telescoping platform having a patient contact surface, a cam contact surface, and four telescoping plunger channels, each channel being configured to receive one of the four plungers, wherein the cam contact surface comprises one or more cam contact areas aligned with one or more of the cams within the enclosure;
wherein operation of the direct current motor rotates the shafts and each cam affixed thereto, causing rotation of the cams and subsequent contacting of the respective cam contact areas of the telescoping platform,
wherein each of the two cams affixed to each shaft is unique and comprises peaks of varying heights and ascend gradients, and troughs of varying depths and descend gradients,
wherein each cam is assembled to be out of phase with the other cams, and
wherein the system is configured to execute multiple displacements of equal magnitude in each of a vertical, a medial-lateral, and an anterior-posterior direction.

US Pat. No. 10,213,360

DIAGNOSTIC AND TREATMENT METHODS

MC HEALTH TECH S.L., Bar...

1. A method of treating a tensional myofascial chain the tensional myofascial chain having a plurality of links and dominating an affected area where the patient is reporting symptoms selected from the group of muscular pain, fascial pain, inflammation, limitation of the joint articulation movement, and stenosis in the vascular, lymphatic or nervous systems, the tensional myofascial chain beginning at an asymptomatic primary lesion and ending at a symptomatic lesion distal from the primary lesion, said method comprising;(i) identifying which link of the chain is the primary lesion, the primary lesion being the link within the tensional myofascial chain which is in the most caudal position; and,
(ii) treating the primary lesion by applying a series of vacuum pulses, each of the vacuum pulses representing a series having a trapezoidal form when the vacuum intensity is represented in the Y axis and time is represented in the X axis.

US Pat. No. 10,213,359

SCAR REDUCTION APPARATUS

I2R MEDICAL LIMITED, Dor...

13. A method of reducing scar tissue prominence, the method comprising the step of imparting a localised positive urging force directly to formed scar tissue via a uniformly or substantially uniformly localised negative pressure differential above the scar tissue, the negative pressure differential being imparted by an at least partially air-evacuated chamber above the scar tissue and wherein said chamber is at least partially air-evacuated prior to application above the scar tissue.

US Pat. No. 10,213,358

MINIATURISED INSTRUMENT FOR SIMULATING SIMULTANEOUS VISION BY GENERATING MASKS

CONSEJO SUPERIOR DE INVES...

1. A miniaturised instrument for simulating simultaneous vision by generating masks, characterised in that it comprises:a mask-generating element which generates at least two complementary masks, with a temporal frequency of alternation such that, sequentially, each mask lets an incident light from an object partially pass, at the same time as the at least one other mask partially blocks said incident light;
an adjustable lens of variable optical power which generates, with said temporal frequency of alternation, at least two different optical powers corresponding to at least two observation distances;wherein the mask-generating element and the adjustable lens are located in a single optical channel wherethrough said incident light circulates, such that each mask of the mask-generating element is temporally synchronised with each power of the adjustable lens, obtaining, via temporal fusion, a combined pupil pattern of at least two observation distances.

US Pat. No. 10,213,357

AMBULATORY EXOSKELETON AND METHOD OF RELOCATING EXOSKELETON

Ekso Bionics, Inc., Rich...

10. An ambulatory exoskeleton comprising:a control system configured to control the exoskeleton in at least two different modes, with one mode constituting an unworn propulsion mode, used when the exoskeleton is not worn by a user, and another mode constituting a default or worn propulsion mode, used when the exoskeleton is worn by a user;
means for causing the control system to enter or exit the unworn propulsion mode; and
means for controlling movement of the exoskeleton in the unworn propulsion mode, wherein the means for controlling includes a handle having a sensor, wherein the control system causes the exoskeleton to move based on a magnitude and a direction of a force applied to the handle as measured by the sensor, wherein the force applied determines when and how fast to take a step, and wherein, when the control system determines that the force is applied to only one side, the control system causes the exoskeleton to take repeated steps on one leg to facilitate turning.

US Pat. No. 10,213,356

ORTHOSIS DEVICE

Cadence Biomedical, Seat...

1. An apparatus comprising:a harness, wherein the harness circumferentially secures a first enclosed region; and
at least one brace comprising:
an articulated frame articulably attached to the harness comprising an upper component, a lower component, and a force-directing device;
the upper component articulably attached to the harness;
the lower component formed to hingeably attach to the upper component at a knee joint;
a pre-tensioning device, wherein the pre-tensioning device is coupled to the harness opposite of the first enclosed region, comprising at least one pawl, a pre-tensioning rim, and a centrally-located gear;
an energy-transforming mechanism comprising an energy storage device coupled to the pre-tensioning device via a superior exotendon and coupled to a lower assembly via an inferior exotendon;
the energy storage device elastically positioned between the force-directing device and the lower assembly; and
the lower assembly coupled to the articulated frame, wherein the lower assembly further comprises a tensioner, a lower wheel coupled to the inferior exotendon, and a foot plate hingeably attached to the lower wheel.

US Pat. No. 10,213,355

THERAPEUTIC PILLOW

1. An adjustable pillow comprising:a foam body having a top surface, an opposing bottom surface, a rear edge and an opposing front edge and lateral sides, wherein the foam body is defined by a first region that includes the front edge, a second region adjacent the first region and a third region adjacent the second region and defining the rear edge, wherein the first region has a convex shape, the second region has a concave shape and the third region has a convex shape, the pillow having a maximum thickness in the first region and a minimum thickness in the second region, the first region having a first section that extends to the front edge and has a positive slope and an adjacent second section that has a negative slope and extends to the second region, wherein the front edge has a height greater than the rear edge; and
a plurality of ribs extending longitudinally between the lateral sides and being located exclusively within the first section of the first region which has positive slope; and one or more foam inserts or foam pads for altering the thickness of the pillow.

US Pat. No. 10,213,354

WHEELED TRANSPORTATION DEVICE

IDEAssociates (IOM) Limit...

1. A wheeled transportation device comprising a base, where the base comprises a front end, a rear end, an upper part and a lower part,said lower part comprising a number of wheels and said upper part comprising at least one substantially horizontal and plane surface,
said wheeled transportation device comprising at least one movable first engagement member adapted to engage a frame part of a bed,
said movable first engagement member being movable between a resting engagement member position and an activated engagement member position, said movable first engagement member extending above said substantially horizontal and plane surface in the activated engagement member position,
wherein said upper part comprises a further engagement member located above said at least one substantially horizontal and plane surface, and
wherein said resting engagement member position is located at or below said at least one substantially horizontal and plane surface.

US Pat. No. 10,213,353

BED STEP STOOL AND METHOD OF USE

1. A bed step stool for assisting a user into and out of bed including opposite sides, a head, and a foot, comprising:a first support to be disposed closer to the head of the bed;
a second support to be disposed closer to the foot of the bed;
a step assembly supported between the first support and the second support, the step assembly to enable the user to step thereon for assisting the user into and out of the bed,
wherein the first support and the second support define an unobstructed pathway for entry and exit with respect to the bed and the bed step stool that is perpendicular with respect to the sides of the bed whereby the user goes between the first support and the second support to step onto the step assembly and off the step assembly without any obstruction.

US Pat. No. 10,213,352

HAND-HELD CONTROL FOR AN ELECTROMOTIVE FURNITURE DRIVE, METHOD FOR DETECTING ACTUATION OF A HAND-HELD CONTROL, AND ELECTROMOTIVE FURNITURE DRIVE

DewertOkin GmbH, Kirchle...

1. A method for detecting an actuation of a hand-held control for an electromotive furniture drive, wherein the hand-held control has at least one detector, comprising the steps of:applying an electric periodic test signal from at least one evaluation unit to at least one sensor surface of at least one detector via detector conductor paths, wherein the at least one evaluation unit is connected to the at least one detector in an electrically conducting manner;
recording a response signal by means of a test signal modified by actuation of the at least one detector;
evaluating the test signal thus obtained using the at least one evaluation unit and producing a logic switching signal for detecting the actuation of the hand-held control,
wherein a height of a signal level of the response signal of the sensor surface of the detector is previously assigned to a related actuation.

US Pat. No. 10,213,351

MOBILE SCREENING APPARATUS

FRAZER, LTD., Houston, T...

1. A mobile screening apparatus comprising:a patient compartment having a floor, an end wall, a first sidewall and a second sidewall, said second sidewall having an expanding wall that is slidable between a retracted position and an extended position;
a vehicle having a chassis upon which said patient compartment is positioned, said vehicle having wheels rotatably mounted to said chassis so as to allow said vehicle to move along an underlying surface;
a scanner positioned in said patient compartment, said scanner having a length dimension and a width dimension, said length dimension extending longitudinally within said patient compartment such that said length dimension of said scanner is aligned with a longitudinal axis of said patient compartment, said length dimension being greater than said width dimension, said scanner having a circular or oval opening.

US Pat. No. 10,213,350

RADIALLY TENSIONED WOUND OR SKIN TREATMENT DEVICES AND METHODS

Neodyne Biosciences, Inc....

1. A dressing system, comprising:a dressing comprising a first edge and a second edge, wherein the second edge has an orientation that is non-parallel and non-orthogonal to the first edge when the dressing is in an unstrained state, and a first face comprising an adhesive;
a frame removably attached to the first edge and the second edge of the dressing, the frame comprising an outer edge, an inner edge, and an opening surrounded by the inner edge wherein the dressing is releasably attached to the frame by an attachment structure and is positioned over the opening; and
a straining structure configured to be pushed through the opening to apply a straining force to a central region of the dressing that radiates from the central region orthogonally to the first edge of the dressing and to the second edge of the dressing by displacing the central region of the dressing by a predetermined distance from the opening.

US Pat. No. 10,213,349

PATIENT INCONTINENCE AND LIFTING PAD

1. A patient incontinence and lifting pad comprises:a bed pad;
a first securing strap;
a second securing strap;
an absorbent incontinence pad insert;
the bed pad comprises a base surface, a cover surface, an outer edge, an inner edge, and a slot;
the base surface and the cover surface being opposite surfaces of the bed pad;
the first securing strap being connected onto the base surface, adjacent to the outer edge;
the second securing strap being connected onto the base surface, opposite to the first securing strap;
the slot traversing through the bed pad from the cover surface to the base surface;
the slot being delineated by the inner edge;
the absorbent incontinence pad insert being positioned within the slot;
the absorbent incontinence pad insert being peripherally mounted to the cover surface; and
the bed pad, the first securing strap, the second securing strap, and the absorbent incontinence pad insert are composed of superabsorbent polymer.

US Pat. No. 10,213,348

ELASTIC STRUCTURE FOR ABSORBENT SANITARY PRODUCTS, AND A METHOD AND APPARATUS FOR ITS PRODUCTION

FAMECCANICA.DATA S.P.A., ...

1. An elastic structure for absorbent sanitary products, comprisinga sleeve comprising a first layer and a second layer overlapping each other,
at least one elastic thread which extends within said sleeve in a longitudinal direction; and
a plurality of first connecting portions spaced apart in the longitudinal direction, wherein each of said first connecting portions comprises two first welds arranged on opposite sides of the thread, wherein the first welds weld said first layer and said second layer to each other in a first longitudinal portion of said sleeve, and wherein said first welds of each of said first connecting portions have respective proximal surfaces facing the thread spaced apart by a distance, less than the diameter of the untensioned thread, in order to anchor the thread to first said longitudinal portion of the sleeve,
characterized in that it comprises a plurality of second connecting portions spaced apart in the longitudinal direction, wherein each of said second connecting portions comprises at least one second weld, wherein said second welds weld said first layer and said second layer to each other in a second longitudinal portion of said sleeve without axially connecting the thread to said second longitudinal portion of the sleeve.

US Pat. No. 10,213,347

ABSORBENT ARTICLE WITH AN APERTURED MULTI-LAYERED TOPSHEET

Kimberly-Clark Worldwide,...

1. An absorbent article that extends in a plane defined by a longitudinal direction and a transverse direction, wherein the article comprises:a liquid permeable multi-layered topsheet having a length in the longitudinal direction, a width in the transverse direction, a longitudinal centerline, and a transverse centerline, wherein the multi-layered topsheet defines a body-facing surface of the absorbent article, the multi-layered topsheet comprising at least a first topsheet layer disposed above a second topsheet layer, wherein the first topsheet layer defines a first opening having a first perimeter, wherein the first topsheet layer and the second topsheet layer are joined by a seal, and further wherein the multi-layered topsheet extends in the longitudinal direction to define a distal end and an opposing proximal end of the absorbent article and in the transverse direction to define a first edge and an opposing second edge of the absorbent article;
a liquid impermeable baffle, wherein the baffle defines a garment-facing surface of the absorbent article;
a first sub-topsheet layer positioned between the second topsheet layer and the baffle, wherein the first sub-topsheet layer defines a second opening having a second perimeter, wherein the first perimeter surrounds the second perimeter; and
a second sub-topsheet layer positioned between the first sub-topsheet layer and the baffle, wherein the second sub-topsheet layer has a shape that includes a first bulge facing the first edge in the transverse direction and a second bulge facing the second edge in the transverse direction, wherein the first bulge and the second bulge are visible from the body-facing surface of the absorbent article, and further wherein the second sub-topsheet layer defines a third opening having a third perimeter.

US Pat. No. 10,213,346

UNIT FOR FORMING ABSORBENT SANITARY ARTICLES AND METHOD FOR MAKING ABSORBENT SANITARY ARTICLES

GDM S.p.A., Bologna (IT)...

1. A unit for forming absorbent sanitary articles, comprising:a drum rotatable about an axis of rotation and having a circumferential peripheral surface movable along a feed direction;
a first feeding device including a rotatable member for feeding a succession of pairs of panels of material facing the circumferential peripheral surface and configured to position each pair such that two panels of each pair of panels are facing each other and transversely aligned with the feed direction;
a second feeding device including a roller for feeding a continuous web of material suitable for defining at least part of a main body of an absorbent sanitary article, and configured to position the continuous web on the circumferential peripheral surface such that each of the two panels projects partly sideways from the continuous web;
an ultrasonic sealing station located along the circumferential peripheral surface, in a zone located operatively downstream of the second feeding device, and configured to attach each of the two panels to the continuous web at at least one plurality of sealing points arranged in succession along the feed direction; the ultrasonic sealing station comprising at least one first sonotrode and at least one second sonotrode facing the circumferential peripheral surface and spaced from each other transversely to the feed direction such that each acts on a respective one of the two panels;
wherein the at least one first sonotrode and the at least one second sonotrode are movable towards and away from each other in order to adapt to a size of the absorbent article.

US Pat. No. 10,213,345

APPARATUS AND PROCESS FOR PROVIDING A COILED COLLAGEN CARRIER

TAKEDA AS, Asker (NO)

1. An apparatus for providing one or more coiled collagen carriers each configured for application to a patient, the apparatus comprising:a device for applying moisture to a collagen carrier so as to moisturise the collagen carrier; and
a coiling device to which the moisturised collagen carrier is conveyed from the moisturising device, the coiling device comprising:
a pair of elongated members for gripping along an edge of the moisturised collagen carrier and coiling the moisturised collagen carrier in a lengthwise or widthwise direction thereof to produce the coiled collagen carrier; and
a support device comprising a tray defining a cavity within which said coiling takes place by the rotatable gripping means, said cavity formed by wall segments of the tray against which the moisturised collagen carrier is supported during said coiling, wherein the support device maintains the coiled shape of the moisturised collagen carrier within the apparatus downstream of the coiling device.

US Pat. No. 10,213,344

DRESSING WITH MOISTURE INDICATOR

Availtek LLC, Carmel, IN...

1. A medical dressing comprising:an adhesive, permeable layer configured to adhere to skin near a wound;
a fabric support disposed on the adhesive, permeable layer;
a hydrochromatic layer disposed on the fabric support configured to change a color appearance responsive to contact with moisture; and
wherein each of the permeable layer and the fabric support define an outer periphery, the outer periphery having a notch therein defining an entry point for a percutaneous device, and wherein the fabric support includes a void spaced apart from the notch, the void configured to align with a percutaneous device insertion site when said dressing is applied to the wound.

US Pat. No. 10,213,343

THREE-LAYERED WOUND DRESSING AND METHOD OF MANUFACTURING THE SAME

FOSHAN UNITED MEDICAL TEC...

1. A method of manufacturing a three-layered wound dressing, the three-layered wound dressing comprising a first layer, a second layer, and a third layer; the first layer comprising a blend of first hydrophilic fibers and first hydrophobic fibers; the second layer comprising a blend of second hydrophilic fibers and second hydrophobic fibers; and the third layer comprising hydrophobic fibers; the second layer being disposed between the first layer and the third layer; and the first layer being adapted to contact a wound; the method comprising one of the following three steps:1) manufacturing the first layer, the second layer and the third layer separately using a heat binding method, or a needle punching method or a hydro entanglement method; then laminating three layers together by heat bonding, or needle punching or chemical bonding, followed by cutting, packing and sterilization;
2) manufacturing the first layer, the second layer and the third layer separately using a heat binding method, or a needle punching method or a hydro entanglement method; laminating the first layer and the second layer together by heat bonding, or needle punching or chemical bonding; and then manufacturing the third layer onto the laminated first/second layer directly, followed by cutting, packing and sterilization; and
3) manufacturing the second layer and the third layer separately using a heat binding method, or a needle punching method or a hydro entanglement method; laminating the second layer and the third layer together by heat bonding, or needle punching or chemical bonding; and manufacturing the first layer onto the laminated second layer/third layer directly, followed by cutting, packing and sterilization.

US Pat. No. 10,213,342

OPHTHALMIC KNIFE AND METHODS OF USE

1. An ophthalmic knife, comprising:a shaft;
a first platform extending radially from a first radial side of the shaft; and
a second platform extending radially from a second radial side of the shaft, opposite the first radial side;
wherein each of the first and second platforms comprises:
a ramp that increases from a first thickness at a distal side of the ramp to a second thickness, greater than the first thickness and at a proximal side of the ramp; and
first and second blades that (i) are separated by a gap and (ii) extend from the proximal side of the ramp to the shaft; and
wherein the shaft, the first platform, and the second platform define a single flat and continuous bottom surface that is opposite each of the first and second blades.

US Pat. No. 10,213,341

LASER PROBE WITH A REPLACEABLE OPTIC FIBER

1. A device comprising:a machine adapter having a machine adapter distal end and a machine adapter proximal
end, the machine adapter configured to interface with an ophthalmic laser to perform a laser
photocoagulation procedure;
a machine adapter inner bore of the machine adapter;
a machine interface of the machine adapter, the machine interface disposed between the
machine adapter distal end and the machine adapter inner bore;
a handle adapter having a handle adapter distal end and a handle adapter proximal end;
an actuation handle having a plurality of actuation arms and a plurality of extension mechanisms;
a replaceable optic fiber;
a pair of connectors of the replaceable optic fiber;
a housing tube having a housing tube distal end and a housing tube proximal end wherein the optic fiber distal end is adjacent to the housing tube distal end;
a first connector of the pair of connectors having a first connector distal end, a first connector proximal end, a first temporary fixation channel, a first interface, a first connector inner bore, a first connector guide cone, and a first optic fiber housing wherein a portion of the first connector is disposed within the handle adapter;
a second connector of the pair of connectors having a second connector distal end, a second connector proximal end, a second temporary fixation channel, a second interface, a second connector inner bore, a second connector guide cone, and a second optic fiber housing wherein a portion of the second connector is disposed within the machine adapter wherein the second connector is identical to the first connector; and
an optic fiber of the replaceable optic fiber having an optic fiber distal end, an optic fiber proximal end, a core, a cladding, and a polyimide buffer wherein the optic fiber is disposed within the first connector and the second connector wherein the optic fiber distal end extends a distal extension distance from the first connector distal end and the optic fiber proximal end extends a proximal extension distance from the second connector distal end wherein the distal extension distance is equal to the proximal extension distance and wherein the optic fiber is fixed in the first connector and wherein the optic fiber is fixed in the second connector and wherein a portion of the replaceable optic fiber is disposed in the machine adapter wherein the optic fiber proximal end is adjacent to the machine adapter distal end.

US Pat. No. 10,213,340

METHODS AND SYSTEMS TO PROVIDE EXCLUDED DEFINED ZONES FOR INCREASING ACCOMMODATIVE AMPLITUDE

Lensar, Inc., Orlando, F...

1. A system for changing the refractive power of an eye, the system comprising:a. a laser for providing a therapeutic laser beam;
b. an optical path for delivery of the therapeutic laser beam from the laser to a natural crystal lens of an eye;
c. optics located along the optical path, the optics providing the capability to direct the laser beam in at least the x and y directions;
d. a control system, comprising a controller, the controller comprising a laser beam delivery pattern, whereby the control system is configured to direct the optics to deliver the laser beam in the laser beam delivery pattern to a predetermined area of the lens of the eye;
e. the laser beam delivery pattern defining an axial excluded zone and an equatorial excluded zone; and,
f. whereby, the delivery of the laser beam in the laser beam pattern to the natural crystalline lens of the eye changes the refractive power of the lens of the eye.

US Pat. No. 10,213,339

METHOD AND DEVICE FOR PRODUCING CURVED CUTS IN A TRANSPARENT MATERIAL

Carl Zeiss Meditec AG, J...

12. An apparatus for isolating a volume of material within a cornea of an eye by producing curved cuts in the cornea, said apparatus comprising:a laser radiation source which focuses laser radiation into the cornea at a focal point and causes optical breakthroughs therein;
a scanning unit which three-dimensionally shifts the focal point, wherein the scanning unit comprises adjustable optics for shifting the focal point in one spatial direction which is parallel to a direction in which the laser radiation is applied;
a control unit which controls the scanning unit, to form the cut surface by sequential arrangement of the optical breakthroughs in the cornea; and
wherein the control unit controls the scanning unit such that the focal point is guided in two other spatial directions on contour lines of the cut, the contour lines being located in planes that are perpendicular to the first spatial direction.

US Pat. No. 10,213,338

DEVICE FOR PRODUCING CUTS OR PERFORATIONS ON AN EYE

1. A device for producing cuts or perforations on a human or animal eye at the anterior or posterior opening of the eye lens (capsulatomy, rhexis), the device comprising a cutting element that can be inserted into an associated interior of an associated eye and a drive device which is arranged outside of the associated eye in order to cause movement, in articular oscillatory vibrations or rotation of the cutting element inside the associated interior of the associated eye, the drive device having a field generator for generating a magnetic or electromagnetic excitation field and the cutting element can be excited, in particular driven, by way of the field generated by the field generator, the cutting element is formed as a continuous cutting ring.

US Pat. No. 10,213,337

VITRECTOMY PROBE

Erre Quadro S.R.L., Pisa...

1. Vitrectomy probe for removing the vitreous humour comprising a single closed-tip tube adapted to be put into direct contact, at least partially, with said vitreous, defining a main axis and including an internal passage and at least one lateral opening to enable said vitreous to enter the internal passage; a suction system for the creation of vacuum within said internal passage sucking said vitreous into said opening; wherein said at least one opening comprises at least one cutting edge; and wherein the probe comprises a drive unit adapted to move said tube with a vibrational motion (A), which vibration motion generates pressure waves reducing the viscosity of said vitreous, and a reciprocating motion (B), which reciprocating motion allows at least one cutting edge to cut said vitreous; and wherein said vibrational motion (A) has a frequency which is higher than the frequency of said reciprocating motion (B).

US Pat. No. 10,213,336

EYE DROP ASSIST APPARATUS

Ocunelis LLC, Ann Arbor,...

1. An eye drop assist apparatus for sequentially administering ocular medication from an eye drop bottle having a dispensing tip to a patient's two eyes, the two eyes separated from one another, said apparatus comprising:a holder defining a bottle support axis, said holder configured to support the eye drop bottle so that the dispensing tip is disposed along said bottle support axis,
a first nasal locator connected to said holder, said first nasal locator extending laterally from said bottle support axis a first offset distance, and
a second nasal locator connected to said holder and spaced from said first nasal locator, said second nasal locator extending laterally from said bottle support axis a second offset distance equal to said first offset distance,
wherein said first nasal locator is defined by a first concave abutment and said second nasal locator is defined by a second concave abutment, said first and second concave abutments including respective first and second apex points, said first and second offset distance measured from said bottle support axis to said respective first and second apex points, the distance between said first and second apex points equal to 60 mm.

US Pat. No. 10,213,335

METHODS AND APPARATUS FOR CRYOGENIC TREATMENT OF A BODY CAVITY OR LUMEN

Channel Medsystems, Inc.,...

1. A tissue treatment system, comprising:an elongate lumen having a distal tip and a length;
at least one infusion lumen positioned through or along the elongate lumen;
at least one delivery lumen in fluid communication with the infusion lumen, wherein the delivery lumen defines one or more openings therealong;
a liner defining an interior in which the elongate lumen is positionable; and
a sheath translatable relative to the elongate lumen, wherein translation of the sheath selectively controls a number of the one or more openings which remain unobstructed and also correspondingly adjusts an expanded length of the liner according to the number of one or more openings which are unobstructed.

US Pat. No. 10,213,334

APPARATUS AND METHOD FOR MODULATING SLEEP

Ebb Therapeutics, Inc., ...

1. A method of enhancing sleep in a subject, the method comprising:securing a thermal transfer region of an applicator in contact with the subject's forehead so that the thermal transfer region does not contact the perioribtal region of the subject's face; and
maintaining the temperature of the thermal transfer region within a target temperature range that is between 25 and 42° C. to enhance the subject's sleep.

US Pat. No. 10,213,333

METHOD OF CONTROLLING IMMUNE CELLS

1. A method for regulating immune cells comprising:applying a stimulus to a specific area to be stimulated at a body surface by a stimulus applying apparatus so as to bring an increase rate of a blood flow to 60% or more, preferably, 100% or more,
wherein the blood flow is measured by a laser Doppler tissue blood flow meter attached to a central part of an inner side of a wrist joint,
wherein the increase rate of blood flow by thermal therapy enables a regulatory T cell to regulate and balance the immune cells and regulating and balancing these T cell groups finely is essential to maintain the immune system of human beings, and
wherein the specific area is at least one area selected from the group consisting of os metatarsale primam 1 and 2 interosseous, os metatarsale primam 2 and 3 interosseous, and part that intersects the perpendicular line of the medial malleolus on an extension line of the medial margin on os metatarsale primam 1 and 2 in foot sole of right and left.

US Pat. No. 10,213,332

SUPRAPUBIC REGION COMPRESSION ASSEMBLY AND METHOD

1. A suprapubic region compression assembly for compressing a suprapubic region of a user, the assembly comprising:a compression plate having opposite inner and outer surfaces and opposite left and right side edge margins, the compression plate defining a notch positioned between the left and right side edge margins, the notch configured to receive a penis of the user, the compression plate comprising a lower portion including the notch and an upper portion, the lower portion having the notch being curved or angled inward toward the inner surface relative to the upper portion to compress the suprapubic region of the user; and
a belt configured to urge the compression plate toward the user such that the compression plate engages the suprapubic region of the user to apply pressure to the suprapubic region thereby increasing a measurable, visible, or usable length of the penis.

US Pat. No. 10,213,330

ORTHOPAEDIC DEVICE FOR A LOWER LIMB OF A HUMAN, FOOTWEAR AND PROSTHESIS PROVIDED WITH SUCH A DEVICE

1. An orthopaedic device for a lower limb of a human comprising:a front segment which is adapted to receive a sole of a forefoot of a foot, said front segment being formed from a first plate;
a rear segment which is adapted to receive a lower face of a heel of said foot, said rear segment being formed from a second plate which is longitudinally spaced from the first plate such that the first plate and the second plate are distinct;
wherein:
said front segment and said rear segment are formed from two pieces which are distinct from one another;
said front segment and said rear segment are connected by at least one upper arch that is resilient in flexion, and
which:
extends above said front segment and said rear segment, providing a recess for receiving said foot;
is adapted to keep said front segment and said rear segment in an inactive position; and
is adapted to make possible a relative displacement of said front segment and said rear segment in relation to one another, starting from the inactive position, and to bring back said front segment and said rear segment resiliently into the inactive position providing a propulsive dynamic effect, said upper arch exerting a force for bringing back said front segment and said rear segment into said inactive position.

US Pat. No. 10,213,329

EVERTABLE SHEATH DEVICES, SYSTEMS, AND METHODS

1. A medical device delivery system comprising:an elongate member having proximal and distal ends;
a medical device having proximal and distal ends; and
an inverted sheath having a delivery profile and a deployment profile, a proximal end and a distal end;
wherein the medical device is located about the distal end of the elongate member with the inverted sheath in the delivery profile disposed about the medical device,
wherein when the inverted sheath is transitioned to the deployment profile, the medical device can be deployed without requiring further eversion of the inverted sheath,
wherein the inverted sheath comprises an inner layer and an outer layer defining a chamber, and
wherein pressurization of the chamber by introducing a fluid into the chamber causes the inverted sheath to evert and causes the transition from the delivery profile to the deployment profile wherein the inverted sheath has an expanded diameter and a shortened length in the deployment profile relative to the delivery profile.

US Pat. No. 10,213,328

PARTIAL ENCAPSULATION OF STENTS

Bard Peripheral Vascular,...

1. An implantable medical device, comprising:an elongate inner tube of expanded polytetrafluoroethylene;
an elongate outer sleeve of expanded polytetrafluoroethylene having a length, the outer sleeve including a plurality of slits oriented longitudinally along a longitudinal axis of the outer sleeve, the plurality of slits having a first group of slits and a second group of slits, wherein the first group of slits and the second group of slits are staggered around a circumference of the outer sleeve, and each of the plurality of slits spanning less than half of the length without extending to either a proximal end or a distal end of the outer sleeve; and
a radially expandable support layer partially encapsulated between the inner tube and the outer sleeve, wherein the support layer comprises a plurality of individual ring stents having a zigzag pattern defining alternating peaks and valleys, and wherein the plurality of slits of the outer sleeve are aligned over the peaks in the zigzag pattern of ring stents of the support layer.

US Pat. No. 10,213,327

IMPLANT WITH ATTACHED ELEMENT AND METHOD OF MAKING SUCH AN IMPLANT

1. A method of making a medical device, comprising:providing an implant defining a longitudinal axis and a terminal end, the implant comprising a plurality of marker carriers disposed at the terminal end;
providing a tube comprising a radiopaque metal, the tube including:
a body portion including an uninterrupted tubular wall defining a lumen;
a ring of spoons, each spoon of the ring of spoons comprising an internal cavity; and
a plurality of bridges connecting the ring of spoons to the body portion, each spoon connected to one of the plurality of bridges, each bridge of the plurality of bridges having a width less than a width of each spoon;
mounting the implant and the tube on separate cores;
aligning each marker carrier of the plurality of marker carriers with the internal cavity of each spoon of the ring of spoons; and
joining the plurality of marker carriers with the ring of spoons, comprising abutting a peripheral surface of each spoon against an exterior surface of a respective marker carrier, wherein each of the peripheral surface and the exterior surface have a complementary taper in a direction across a thickness thereof.

US Pat. No. 10,213,326

STENT GRAFT WITH FENESTRATION

Cook Medical Technologies...

1. An endovascular prosthesis comprising:a tubular body having a wall and comprising a graft material;
a shaped protrusion extending from the wall and comprising a cured thermoset graft material formed into a curved shape, the shaped protrusion having an outer edge and an inner edge at least partially surrounded by the outer edge and being void of structures other than the thermoset material that extends radially between the edges; and
a fenestration having fluid communication through the wall and disposed within the inner edge of the shaped protrusion,
wherein the shaped protrusion is semi-rigid.

US Pat. No. 10,213,325

SUSPENSION LINER WITH SEAL COMPONENT

OSSUR HF, Reykjavik (IS)...

1. A liner for providing an interface between a residual limb and a prosthetic socket, comprising:an elongate, generally conical liner body being radially elastically extensible and including proximal and distal end areas, the liner body having an exterior surface and defining a longitudinal axis defined between the proximal and distal end areas;
the liner body formed with a circumferential recess defining first and second exterior surfaces within the recess and axially separated from one another by a circumferential edge;
a seal component located within the circumferential recess;
wherein the seal component defines a base portion secured to the second exterior surface of the recess;
wherein an interior surface of the base portion is anchored circumferentially to the second exterior surface;
wherein the interior surface of the base portion extends to a pivot line defined by the seal component, a lip extends above the base portion and is parallel to the first exterior surface of the circumferential recess.

US Pat. No. 10,213,324

MINIMUM JERK SWING CONTROL FOR ASSISTIVE DEVICE

Rehabilitation Institute ...

1. A method for control of an assistive device, comprising:a. computing a first set of coefficients of a first polynomial function, to determine at least one angle position for an ankle joint of the assistive device when the assistive device is in a swing phase;
b. computing a second set of coefficients of a second polynomial function and a third set of coefficients of a third polynomial function, to determine at least one angle position for a knee joint of the assistive device when the assistive device is in the swing phase;
c. determining the at least one angle position for the knee joint and determining the at least one angle position for the ankle joint; and
d. setting the ankle joint to the determined ankle position and setting the knee joint to the determined knee position;
wherein the second polynomial function determines the angle position for the knee joint during a first portion of the swing phase and the third polynomial function determines the angle position for the knee joint during a second portion of the swing phase;
wherein the first portion of the swing phase is defined by a period from the beginning of the swing phase to a maximum knee flexion position; and
wherein the second portion of the swing phase is defined by a period from the end of the first portion of the swing phase to the end of the swing phase.

US Pat. No. 10,213,323

HYBRID TERRAIN-ADAPTIVE LOWER-EXTREMITY SYSTEMS

Bionx Medical Technologie...

1. An apparatus comprising:a foot member,
a lower leg member,
an ankle joint for connecting the foot member to the lower leg member, and
a controller configured to:
analyze a cost function based on a projected force imparted on the lower leg member during a period of time between when a heel of the foot member strikes underlying terrain to when the foot member is positioned in a flat-foot position relative to the underlying terrain, and
adjusting an impedance of the apparatus based on the cost function.

US Pat. No. 10,213,322

INTERVERTEBRAL DISC AND INSERTION METHODS THEREFOR

SpineCore, Inc., Allenda...

1. A surgical method comprising the steps of:selecting a dispenser engaged with two members of an implant, each of the first and second members including at least one protrusion for association with one of a first vertebral body and a second vertebral body, the dispenser shaped so that at least a portion of the protrusion on each of the first and second members is exposed while the dispenser holds the first and second members in registration;
providing an inserter shaft; and
implanting the first and second members between the first and second vertebral bodies by manipulating the inserter shaft.

US Pat. No. 10,213,321

BONE FUSION SYSTEM, DEVICE AND METHOD INCLUDING DELIVERY APPARATUS

Neuropro Technologies, In...

1. A bone fusion system for inserting material into a bone fusion device in a desired location, the system comprising:a bone fusion device having a body with one or more device channels, a positioning element having a positioning aperture and one or more extendable tabs, wherein manipulation of the positioning element enables the tabs to be extended away from the body; and
a delivery apparatus comprising a docking rod and a delivery member having an elongated hollow shaft that leads to an exit aperture, wherein a tip of the docking rod detachably couples to the bone fusion device within the positioning aperture and the delivery member detachably couples with the docking rod such that the exit aperture aligns with one of the device channels when the rod is coupled to the bone fusion device,
wherein the delivery member includes a funneling chamber having a threaded chamber end, wherein the elongated hollow shaft provides a path from the funneling chamber to the exit aperture.

US Pat. No. 10,213,320

SURGICAL GUIDE FOR IMPLANTING A KNEE PROSTHESIS

MEDACTA INTERNATIONAL SA,...

1. A surgical guide for implanting a knee prosthesis, the surgical guide comprising:a first component intended for coupling with a distal epiphyseal end of a femur and comprising
at least one attachment portion configured to be fixed to the distal epiphyseal end of the femur, and
an attachment plate having a substantially triangular shape and comprising a connection to said at least one attachment portion configured to be adjacent to the distal epiphyseal end of the femur;
a template configured to guide a marking operation of the distal epiphyseal end of the femur to determine a position of the knee prosthesis;
said template configured to be rotatably mounted relative to said first component, and comprising a slot perpendicular to a symmetry axis of said template; and
a second component configured to couple said template with a proximal epiphyseal end of a tibia corresponding to the distal epiphyseal end of the femur;
said second component comprising
a grip,
a coupling portion extending from said grip and towards said template for placement adjacent the distal epiphyseal end of the femur, and
a tab being parallel to said coupling portion and extending from said grip, said tab configured to be inserted into said slot.

US Pat. No. 10,213,319

NAVIGATION DEVICE FOR JOINT REPLACEMENT AND SURGICAL SUPPORT DEVICE

ARTHRODESIGN, LTD., Kawa...

1. A navigation device for joint replacement, the navigation device comprising:a guide instrument for guiding a position of a surgical instrument when performing a joint replacement, the guide instrument having
a fixing support unit for fixing and supporting the guide instrument to a surgical object,
an operating unit to which the surgical instrument or a shape measuring instrument is detachably attached,
an imaging unit slidably held by the fixing support unit for detecting signals from the shape measuring instrument when the shape measuring instrument is attached to the operating unit, and
a positioning arm unit joined to the operating unit for adjusting positions of the operating unit and the imaging unit relative to a position of the fixing support unit;
a bone shape calculating means configured to calculate a virtual three-dimensional bone shape of a joint part of a surgical object based on image data of a patient before surgery;
a guide installation position calculating means configured to calculate an ideal installation position of the guide instrument based on the virtual three-dimensional bone shape before surgery;
a bone shape obtaining means configured to obtain an actual three-dimensional bone shape of the joint part of the surgical object, during surgery, by the shape measuring instrument attached to the guide instrument actually installed;
a guide installation position obtaining means configured to obtain an actual installation position of the guide instrument, during surgery, by the shape measuring instrument attached to the guide instrument actually installed; and
an error detecting means configured to compare the virtual three-dimensional bone shape, ideal installation position of the guide instrument, actual three-dimensional bone shape and actual installation position of the guide instrument of the respective means, and to detect an error between the actual installation position and the ideal installation position of the guide instrument by shifting the actual installation position to align with the ideal installation position.

US Pat. No. 10,213,318

SPINAL CAGE DEVICE, SYSTEM, AND METHODS OF ASSEMBLY AND USE

REFAI TECHNOLOGIES, LLC, ...

1. A cage system, comprising:a cage, comprising:
a body portion;
at least one opening through the body portion in a superior-inferior direction; and
at least one hole in an anterior surface of the body portion extending into the at least one opening, wherein the at least one hole comprises:
a first section near the anterior surface of the cage; and
a second section adjacent to the first section and extending into the at least one opening in the body portion,
wherein the first section has a larger diameter than the second section and the first section and second section are threaded; and
at least one locking screw assembly configured to couple to the cage.

US Pat. No. 10,213,317

IMPLANT WITH SUPPORTED HELICAL MEMBERS

Institute for Musculoskel...

1. An implant, comprising:a body;
the body defining a transverse plane dividing the implant into a superior half and an inferior half;
a peripheral frame portion defining a periphery of the body;
a central wall extending from a first side of the peripheral frame portion to a second side of the peripheral frame portion;
a first helical bone contacting member attached to the body and disposed within the superior half of the implant;
a second helical bone contacting member attached to the body and disposed within the superior half of the implant;
a first support member extending from a first point on a superior side of the peripheral frame portion to the first the bone contacting member and further extending inwardly of the bone contacting member into a central region of the implant and terminating at a second point on an inferior side of the peripheral frame portion adjacent to the first point from which the first support member extends; and
a second support member extending from a third point on the peripheral frame portion opposite the first point to the second helical bone contacting member and further extending inwardly of the bone contacting members and terminating at a fourth point on the peripheral frame portion;
wherein the first support member and the second support member are substantially U-shaped and are connected to one another at the bottoms of the two U-shapes in the central region of the implant inward of the bone contacting members.

US Pat. No. 10,213,316

PROSTHESIS

SWEMAC INNOVATION AB, (S...

1. Wrist prosthesis for replacement of a wrist joint (arthroplasty), and subsequently for arthrodesis of the wrist joint,wherein the prosthesis (1) comprises two elongated prosthesis members (2, 3) which each is configured for attachment thereof to at least one of the bones at the joint,
wherein one of the prosthesis members (2) comprises a first screw-like attachment member (4) which is configured for attachment to at least one of the bones at the joint and the other prosthesis member (3) comprises a second screw-like attachment member (5) which is configured for attachment to at least one other bone at the joint, and
wherein said one prosthesis member (2) originally comprises a socket member (6) and said other prosthesis member (3) originally comprises a head member (7),
wherein said socket member (6) is configured with an attachment pin (16) which is insertable into a hole (8) in the first screw-like attachment member (4) for attachment of the socket member therein,
wherein said head member (7) is configured with an attachment pin (19) which is insertable into a hole (9) in the second screw-like attachment member (5) for attachment of the head member therein,
wherein the hole (9) in the second screw-like attachment member (5) is configured to define a press fit with the attachment pin (19) of the head member (7),
wherein the hole (8) in the first screw-like attachment member (4) is configured to define a press fit with the attachment pin (16) of the socket member (6) and at least partly threaded (14) to subsequently permit, after removal of the socket member (6) during arthrodesis, securing by screwing in said hole of a locking member (33c) which is configured to cooperate with a lockable member (34c),
wherein said one prosthesis member (2) further comprises a locking member (33c) and said other prosthesis member (3) further comprises a lockable member (34c),
wherein the locking member (33c) is configured with an attachment portion (16c) which is insertable into said hole (8) in said first screw-like attachment member (4) for subsequent attachment or location of the locking member therein when the socket member (6) is removed from the first screw-like attachment member (4),
wherein the lockable member (34c) is configured with an attachment portion (19c) which is insertable into said hole (9) in said second screw-like attachment member (5) for subsequent attachment or location of the lockable member therein when the head member (7) is removed from the second screw-like attachment member (5),
wherein the locking member (33c) is also configured with a locking portion (37c) which is connected to the attachment portion (16c) and configured for fixation or attachment of the lockable member (34c) thereto, and wherein the attachment portion (16c) is configured with a hole (38c) which extends through said attachment portion and in the longitudinal direction thereof for insertion therein of a partly threaded attachment means (39c) for tightening or securing by screwing the locking member (33c) to the first screw-like attachment member (4) by bringing said attachment means (39c) to cooperate with a threaded portion (14c) of the hole (8) in said first screw-like attachment member (4),
wherein the locking portion (37c) of the locking member (33c) is substantially U-shaped and comprises two shanks (40c) with two holes (41c, 42c) provided in each shank (40c) opposite each other and substantially in line in the longitudinal direction of the locking portion (37c), whereby one hole (41c) is configured for a locking means (43c) for fixation or attachment of the lockable member (34c) to the locking member (33c) and whereby the other hole (42c) is configured for a pivoting axis member (44c) about which the lockable member can pivot for adjustable setting thereof relative to the locking member,
wherein the lockable member (34c) comprises a lockable portion (45c) which is configured for insertion between the shanks (40c) of the locking portion (37c) of the locking member (33c), wherein the lockable portion (45c) is configured with a curved long-hole (46c) for said locking means (43c) that extends transversely therethrough, and with a hole (47c), also extending transversely through said lockable portion, for the pivoting axis member (44c) about which the lockable member (34c) can pivot for adjustable setting thereof relative to the locking member, and wherein at insertion of the lockable portion (45c) between the shanks (40c) of the locking portion (37c) of the locking member (33c), portions of the long-hole (46c) are brought in line with the holes (41c) in said shanks to allow the locking means (43c) to pass through the long-hole (46c) and the holes (41c) for fixation or attachment of the lockable portion to the locking portion of the locking member and the hole (47c) for the pivoting axis member (44c) is brought in line with the holes (42c) for said pivoting axis member (44c) in said shanks,
wherein said lockable member (34c) is configured for adjustable setting thereof relative to the locking member (33c) and for fixation thereof, in set position, to the locking member, and
wherein one prosthesis member (2) is configured for attachment to the radius (25) and the other prosthesis member (3) is configured for attachment to one of the bones (27) of the carpus (26) and a metacarpal bone (28).

US Pat. No. 10,213,315

ATTACHMENTS FOR ORTHOPEDIC IMPLANTS

Zimmer, Inc., Warsaw, IN...

1. A prosthesis positionable between a first bone surface and a second bone surface in a patient, comprising:a first prosthetic component with a first attachment profile that is associable with a mating profile of the first bone surface in a male-female mating relationship and a second attachment profile that is associable with a mating profile of the second bone surface in a male-female mating relationship; and
a stackable, second prosthetic component stackable onto the first prosthetic component, the second prosthetic component including an attachment profile that replicates the first attachment profile of the first prosthetic component to allow association with the mating profile of the first bone surface in a male-female mating relationship and a mating profile that replicates the mating profile of the first bone surface to allow association with the first attachment profile of the first prosthetic component in a male-female mating relationship.

US Pat. No. 10,213,314

FEMORAL COMPONENT FOR AN IMPLANTABLE HIP PROSTHESIS

DEPUY SYNTHES PRODUCTS, I...

1. A method of manufacturing an orthopaedic hip prosthesis comprising:forming a core from a material having a high tensile strength and a high elastic modulus, and
attaching a polymeric shell to the core to position a proximal end of the core in a base of a tapered post of the polymeric shell, wherein attaching the polymeric shell includes placing a cover layer of the polymeric shell only on a lateral surface of a distal end of the core,
wherein the tapered post of the polymeric shell extends from the base to a proximal tip, and the tapered post is sized to be received in a tapered bore of an implantable head component.

US Pat. No. 10,213,313

FEMORAL HEADS, MOBILE INSERTS, ACETABULAR COMPONENTS, AND MODULAR JUNCTIONS FOR ORTHOPEDIC IMPLANTS AND METHODS OF USING FEMORAL HEADS, MOBILE INSETS, ACETABULAR COMPONENTS, AND MODULAR JUNCTIONS FOR ORTHOPEDIC IMPLANTS

The General Hospital Corp...

1. An orthopedic implant comprising:a femoral head implant that includes a portion of an outer surface thereof having a peripheral portion that is contoured so as to achieve an inward shift of the outer surface relative to an overall spherical geometry of the femoral head implant;
wherein the femoral head implant has a femoral head rim comprising an edge or surface marking an end of a femoral head articular surface of the femoral head implant;
wherein the femoral head implant has a femoral head axis defined by a reference line passing through a center of the overall spherical geometry of the femoral head implant to a geometric center of the femoral head rim of the femoral head implant;
wherein the inward shift occurs at an angle greater than about 80° measured from an intersection of the femoral head axis with the outer surface of the femoral head implant; and
wherein the portion that is contoured extends to the femoral head rim, and the inward shift of the outer surface is achieved using at least one convex radius having a value no less than 15% of the overall spherical radius of the femoral head implant.

US Pat. No. 10,213,312

HEATED BOLT FOR MODULAR HIP STEM

Zimmer, Inc., Warsaw, IN...

1. A modular hip stem, comprising:a distal stem configured to be implanted within a femur of a patient;
a proximal body configured to attach to a proximal end of the distal stem;
a bolt configured to secure the proximal body to the distal stem, the bolt defining an internal volume extending longitudinally within the bolt from a proximal end of the bolt toward a distal end of the bolt;
an electrical resistive heater, disposed within the internal volume of the bolt, extending from the proximal end of the bolt toward the distal end of the bolt, and configured to heat the bolt to a temperature greater than average human core body temperature; and
a first electrode extending proximally from the electrical resistive heater to an exterior of the bolt, the first electrode configured to supply current to the electrical resistive heater, the first electrode attached to the electrical resistive heater at a narrowed portion of the first electrode, the narrowed portion being defined by a perforation, the first electrode configured to irreversibly detach from the electrical resistive heater by tearing at the narrowed portion when the first electrode is pulled away from the bolt.

US Pat. No. 10,213,310

DUAL MODULUS HIP STEM AND METHOD OF MAKING THE SAME

DePuy Synthes Products, I...

1. A method of manufacturing an orthopaedic prosthesis for a patient, comprising:producing a shell from a metallic foam material having a first elastic modulus,
producing a stem core from a metallic material having a second elastic modulus greater than the first elastic modulus, the stem core including a neck configured to receive a femoral head component, and
securing the shell to the stem core such that (i) a sheath of the shell is positioned over a proximal segment of the stem core, and (ii) a cover layer of the shell extends along a lateral surface of a distal segment of the stem core, wherein the cover layer has a body that extends distally from a proximal end attached to the sheath to a distal tip of the stem core, the body having a first body thickness at the proximal end that is greater than a second body thickness at the distal tip,
wherein when the orthopaedic prosthesis is viewed in a transverse plane extending through the cover layer and the distal segment of the stem core, (i) the cover layer defines a first cross-sectional area, (ii) the cover layer and the distal segment of the stem core define a second cross-sectional area, and (iii) a ratio of the first cross-sectional area to the second cross-sectional area is greater than 0.30.

US Pat. No. 10,213,309

TISSUE INTEGRATION DESIGN FOR SEAMLESS IMPLANT FIXATION

1. A musculo-skeletal implant comprising a first end having a vertebral-contacting surface to contact a first vertebra, a second end having a vertebral-contacting surface to contact a second vertebra, a longitudinal axis extending through respective centers of the first and second ends, an outer fenestrated wall extending from the first end to the second end, and a monolithic inner fenestrated wall inside the outer fenestrated wall and extending entirely around the longitudinal axis to laterally surround a central hollow cavity that extends through the first and second ends,wherein an open space extends through the first and second ends and between the inner fenestrated wall and the outer fenestrated wall from the first end to the second end, wherein fenestrations of the outer fenestrated wall extend toward the inner fenestrated wall and into the open space, wherein fenestrations of the inner fenestrated wall are arranged laterally around the longitudinal axis, wherein the open space extends through the first end to an outside of the implant via a plurality of individual openings each forming a shape with a different number of sides than at least one of the fenestrations of the inner or outer fenestrated walls, and wherein at least one linear pathway extends unobstructed from the hollow cavity through respective fenestrations of the inner and outer fenestrated walls to the outside of the implant,
wherein the inner fenestrated wall is integrally connected with the outer fenestrated wall by a plurality of interconnecting members, wherein first ones of the interconnecting members located at an end face at the first end at least partially define the individual openings and have at least a portion that faces away from all other parts of the implant, while another one of the interconnecting members is spaced apart from the first and second ends,
wherein at least two of the interconnecting members are aligned laterally around the longitudinal axis, and wherein a distance between the inner and outer fenestrated walls at one of the interconnecting members is substantially the same as a distance between the inner and outer fenestrated walls at a location between two laterally adjacent ones of the interconnecting members, and
wherein the inner and outer fenestrated walls comprise a non-biodegradable material and are permanently fixable with a host body tissue by integration as a structural support of the inner and outer fenestrated walls therewith.

US Pat. No. 10,213,308

PROSTHESIS INCLUDING BALL AND SOCKET ARRANGEMENT

Aptis Medical, LLC, Glen...

1. A prosthesis for replacing a mammalian joint, comprising:a first body, including a ball mounted on a shaft;
a second body, including a base and a cap which secures to the base, said base and cap each having an inner surface and an outer surface, with the inner surfaces of the base and cap together defining a socket which receives and traps the ball and supports the ball for rotation relative to the second body;
wherein one of said inner and outer surfaces of said base defines a first groove, and said cap has a first leg projecting in a first direction and being received in said first groove by sliding into said first groove in said first direction;
and further comprising a second leg on one of said base and said cap and a second groove on the other of said base and said cap, said second leg and second groove lying parallel to and directly opposite said first leg and said first groove, wherein said second leg slides into and is received in said second groove when said first leg slides into and is received in said first groove;
wherein said first leg defines a first leg opening having an axis extending in a direction that is cross-wise to the first direction, said second leg defines a second leg opening coaxial with the first leg opening, and said base defines a base opening which is aligned with said first leg opening when the base and cap are assembled together; and
a pin received in said first leg opening, said second leg opening, and said base opening and extending in the cross-wise direction to secure the cap and base together so that an attempt to slide the cap and base apart from each other in the first direction applies shear forces to the pin; and
means for preventing the first leg from moving outwardly away from the first groove in the cross-wise direction when the first leg is received in the first groove;
wherein said means for preventing the first leg from moving outwardly away from the first groove includes at least a portion of said base contacting the outer surface of the first leg.

US Pat. No. 10,213,307

TRANSCATHETER VALVE PROSTHESIS HAVING AN EXTERNAL SKIRT FOR SEALING AND PREVENTING PARAVALVULAR LEAKAGE

MEDTRONIC VASCULAR, INC.,...

1. A transcatheter valve prosthesis comprising:a tubular stent including a plurality of openings and having a compressed configuration for delivery within a vasculature and an expanded configuration for deployment within a native heart valve;
a skirt coupled to the tubular stent, the skirt including only a single layer of skirt material, a first portion of the skirt being attached to and covering an inner circumferential surface of the tubular stent and a second portion of the skirt being attached to and covering an outer circumferential surface of an inflow end of the tubular stent, wherein the skirt is continuous from the first portion to the second portion such that the first and second portions do not overlap and only the single layer of skirt material covers the tubular stent at any longitudinal position thereof and wherein the single layer of skirt material includes a plurality of cuts therein that are positioned to permit the skirt to extend from the inner circumferential surface to the outer circumferential surface of the tubular stent through the plurality of openings; and
a prosthetic valve component disposed within and secured to the first portion of the skirt.

US Pat. No. 10,213,306

MINIMALLY INVASIVE HEART VALVE REPAIR IN A BEATING HEART

NeoChord, Inc., St. Loui...

1. A method of minimally invasively performing an edge to edge heart valve leaflet repair on a beating heart of a patient, comprising:accessing an interior of a beating heart of a patient minimally invasively;
inserting one or more sutures into each of a first valve leaflet and a second valve leaflet of a heart valve in the beating heart of the patient, each suture having a pair of suture ends;
providing a plurality of suture pairs, each suture pair including one of the pair of suture ends of a suture inserted through the first valve leaflet and one of the pair of suture ends of a suture inserted through the second valve leaflet;
advancing one or more tourniquet tubes over the suture pairs towards the heart valve such that the sutures are drawn into a coaptation tension in which the first valve leaflet and the second valve leaflet are in a coapted position;
securing the sutures at the coaptation tension;
withdrawing the one or more tourniquet tubes from the suture ends after securing the sutures; and
anchoring the suture ends at a wall of the heart with the sutures in the coaptation tension,
wherein securing the sutures at the coaptation tension includes:
securing the one or more tourniquet tubes with respect to the suture pairs with the sutures in the coaptation tension;
advancing a suture loop of a ligature suture along the one or more tourniquet tubes to the first valve leaflet and the second valve leaflet; and
securing the suture loop around the sutures with the sutures in the coaptation tension.

US Pat. No. 10,213,305

DEVICE AND METHOD FOR IMPROVING HEART VALVE FUNCTION

Edwards Lifesciences AG, ...

1. A blood-flow controlling device for treating a mitral or tricuspid valve in need thereof, the device comprising:a blood-flow blocking portion comprising an elongate structure with a substantially cylindrical portion, a portion of the blood-flow blocking portion disposable between leaflets of a native mitral or tricuspid valve and fillable with blood;
a flexible, elongate body portion passing inside of the blood-flow blocking portion, the blood-flow blocking portion slidable up and down the body portion;
an anchor portion disposed on a distal end of the elongate body portion, the anchor portion engageable with heart tissue at or adjacent a heart apex, the anchor portion comprising a tubular body and a plurality of pointed, elongated prongs emanating from a distal end of the tubular body, the plurality of elongated prongs self-expandable from a compressed configuration, in which the plurality of elongated prongs extend distally, and an expanded configuration, in which the plurality of elongated prongs are deflected radially outward relative to a center of the tubular body;
an anchor delivery catheter for delivering the anchor portion having a distal end sheath that maintains the plurality of elongated prongs in the compressed configuration; and
a locking catheter slidable along the elongate body portion,
wherein the locking catheter is operable to lock the blood-flow blocking portion to the elongate body portion, preventing sliding therebetween.

US Pat. No. 10,213,304

APPARATUS, SYSTEM, AND METHOD FOR TREATING A REGURGITANT HEART VALVE

THE CLEVELAND CLINIC FOUN...

1. A method for treating regurgitation of blood through a diseased heart valve having at least two leaflets, said method comprising the steps of:providing a system comprising an apparatus and an adjustment member, the apparatus including a lollipop-shaped body member having a proximal end portion, a distal end portion, and an intermediate portion extending between the distal end portions, the intermediate portion including an expandable occluding member having an adjustable diameter, the proximal end portion being physically connected to the occluding member and including a connecting mechanism that is operably connected to the adjustment member, and the distal end portion including an anchoring member;
securing the anchoring member in a heart chamber containing the heart valve;
operating the adjustment member so that the anchoring member is securely positioned within heart tissue associated with the diseased heart valve; and
operating the adjustment member to increase or decrease the diameter of the occluding member so that at least one of the diseased heart valve leaflets coapts with the occluding member during the cardiac cycle;
wherein after the anchoring member is secured in the heart chamber, blood is permitted to flow through at least a portion of the occluding member.

US Pat. No. 10,213,303

RAPID DEPLOYMENT ARTIFICIAL CHORDAE TENDINAE SYSTEM

On-X Life Technologies, I...

1. An artificial chordae tendineae kit comprising:a hollow first needle including a first proximal end portion having a first proximal aperture, a first distal end portion having a first distal aperture, and a first middle portion coupling the first proximal end portion to the first distal end portion;
a flexible first chord coupled to both a first proximal anchor and a first distal anchor;
wherein the first proximal end portion includes a first proximal inner diameter directly adjacent the first proximal aperture, the first distal end portion includes a first distal inner diameter directly adjacent the first distal aperture, the first middle portion includes a first narrowed portion with a first middle inner diameter that is less than either of the first proximal inner diameter and the first distal inner diameter;
wherein the first chord, the first proximal anchor, and the first distal anchor are all included within the first needle with the first distal anchor distal to the first narrowed portion and the first proximal anchor proximal to the first narrowed portion;
wherein the first needle includes a long axis, the first chord includes a long axis, the first proximal anchor includes a long axis, and the first distal anchor includes a long axis;
wherein the long axes of the first proximal and distal anchors are substantially parallel to the long axis of the first needle when the first chord is included within the first needle;
wherein the first proximal and distal anchors are each configured to rotate when deployed from the first needle such that the long axes of the first proximal and distal anchors are each nonparallel to the long axis of the first chord;
wherein the first proximal anchor is deformable and configured to deform to slide past the first narrowed portion.

US Pat. No. 10,213,302

VALVE PROSTHESIS AND METHOD FOR DELIVERY

MEDTRONIC, INC., Minneap...

1. A valve prosthesis comprising:a valve body; and
a unitary frame including
a first tubular portion connected to the valve body, and
a second tubular portion configured to contact and conform to a native valve annulus in situ,
the unitary frame having
a delivery configuration in which the first tubular portion is positioned in series with the second tubular portion along a longitudinal axis of the unitary frame and the first tubular portion is longitudinally adjacent to the second tubular portion, and
an expanded configuration in which the first tubular portion is positioned within an interior area of the second tubular portion, such that the second tubular portion surrounds the first tubular portion and both of the first tubular portion and the second tubular portion extend parallel to the longitudinal axis of the unitary frame.

US Pat. No. 10,213,301

SYSTEMS AND METHODS FOR HEART VALVE THERAPY

Caisson Interventional, L...

1. A deployment frame system for controlling relative movements of a system of multiple catheters wherein at least one catheter of the multiple catheters is configured to deliver a medical device, the deployment frame system comprising:a plurality of clamps, each of the clamps configured to releasably clamp a proximal end portion of a respective catheter of the multiple catheters;
a first frame, wherein at least one of the clamps is releasably coupled with the first frame;
a second frame, wherein at least two of the clamps are releasably coupled with the second frame, wherein the second frame is translatable parallel to a longitudinal axis of the first frame; and
a frame clamp mechanism whereby the second frame is damnable to the first frame at a plurality of relative longitudinal orientations between the first frame and the second frame.

US Pat. No. 10,213,300

HYPOTUBE SHAFT WITH ARTICULATION MECHANISM

St. Jude Medical, Cardiol...

1. A device for delivering a medical aid into a patient, the device comprising:a hollow shaft having proximal and distal ends, a longitudinal axis, and flexible and rigid portions between the proximal and distal ends, the flexible portion being configured to bend away from the longitudinal axis and the hollow shaft distal end having an end face;
a guide bushing having a first lumen, an exterior surface, and a body defined between the first lumen and the exterior surface, a portion of the exterior surface of the guide bushing abutting the end face of the hollow shaft distal end;
a pull wire directly attached to and extending within the body of the guide bushing;
a flexible tube extending through the first lumen of the guide bushing; and
a sheath mechanically coupled to the flexible tube, the sheath surrounding a distal end of the flexible tube in a first position and being slidable to a second position to expose the distal end of the flexible tube,
wherein the guide bushing is in a first position when the pull wire is in a first position and the guide bushing is in a second position when the pull wire is in a second position.

US Pat. No. 10,213,299

VALVE DELIVERY SYSTEM WITH PINLESS RELEASE MECHANISM

BOSTON SCIENTIFIC SCIMED ...

1. A medical device, comprising:an inner shaft having a distal end region;
a valve implant releasably coupled to the distal end region;
wherein the valve implant is capable of shifting between an elongated configuration and an expanded configuration;
a deployment sheath capable of being disposed about the valve implant when the valve implant is in the elongated configuration;
a post assembly disposed along the valve implant;
wherein the post assembly includes a release member that is axially slidable within an opening in the post assembly, wherein a portion of the release member extends through the post assembly;
a rod designed to engage the release member, wherein the rod is designed to shift the valve implant between the elongated configuration and the expanded configuration; and
wherein shifting the portion of the release member extending through the post assembly from a first axial position within the post assembly to a second axial position within the post assembly releases the rod from the post assembly and deploys the valve implant;
wherein the rod has a forked distal end region.

US Pat. No. 10,213,298

PERCUTANEOUS HEART VALVE PROSTHESIS

Percutaneous Cardiovascul...

1. A percutaneous mitral valve prosthesis, comprising:a valve body having a valve body inlet end, a valve body outlet end and a passage extending along a longitudinal axis between said valve body inlet end and said valve body outlet end, said valve body being collapsible about said longitudinal axis for delivery via a catheter;
a plurality of flexible valve leaflets made from pericardial material, the valve leaflets secured to said valve body and extending across said passage such that valve leaflets collapse toward each other for blocking a blood flow in one direction through said passage from said valve body outlet end to said valve body inlet end;
a flexible skirt extending about a periphery of said valve body, said flexible skirt adapted for blocking the blood flow in said one direction between said valve body and the native wall of a mitral valve orifice; and
a plurality of prongs secured to said outlet end of said valve body and extending toward said inlet end of said body;
wherein said valve body tapers toward said valve body inlet end such that a diameter of the valve body inlet end is smaller than a diameter of the valve body outlet end;
wherein said valve body comprises a valve body frame comprising a plurality of valve body frame elements arranged to form a plurality of circumferentially extending rows of cells, wherein one row of cells comprises a plurality acute-angled vertices at said valve body inlet end and another row of cells comprises a plurality of acute-angled vertices at said valve body outlet end.

US Pat. No. 10,213,297

CONTROLLING TISSUE ENGINEERED HEART VALVE GEOMETRY BY USING PREDEFINED INSERTS DURING CULTURE

UNIVERSITAET ZUERICH, Zu...

1. A heart valve culturing device, wherein the heart valve comprises at least two leaflets, the device comprising:a. a support base; and
b. at least two inner arms each capable of supporting a tissue growth material to from one of the leaflets,
wherein each of the inner arms has a first portion and a second portion,
wherein the first portion is disposed normal to the support base and disposed proximal to a center of the support base,
wherein the second portion is nonlinear and disposed distal to the support base and blends away from the center of the support base,
wherein the at least two inner arms are spaced from each other defining enough space to fit at least the respective tissue growth materials;
the device further comprising a spacer to fit in said space and to separate the tissue growth materials supported by each of the linear portions of the inner arms;
the spacer comprises at least two planar surfaces, all of the planar surfaces having a common intersection line, the intersection line being substantially parallel to and circumferentially surrounded by said linear portions of the inner arms.

US Pat. No. 10,213,296

GRAFT INCLUDING OSSEOUS TISSUE AND CARTILAGE TISSUE FOR AUGMENTATION RHINOPLASTY, AND METHOD OF PERFORMING AUGMENTATION RHINOPLASTY USING THE GRAFT

1. A method of performing augmentation rhinoplasty, the method comprising:providing at least one first graft by isolating at least one part of a nasal septum from a nose of a subject, wherein the at least one first graft comprises both a first compartment consisting of osseous tissue and a second compartment consisting of cartilage tissue;
manufacturing a second graft for forming a line of nasal dorsum of the subject by excising a part of the at least one first graft, wherein the second graft comprises both a first compartment consisting of osseous tissue and a second compartment consisting of cartilage tissue;
preparing at least two pieces of the first graft by cutting another part of the at least one first graft, which remains after the manufacturing of the second graft, into at least two pieces, wherein the pieces of the first graft include pieces of bone, cartilage, or cartilage tissue;
forming two lines of nasal dorsum by inserting the second graft into a nasal dorsum of the subject; and
raising the nasal dorsum in a dorsal direction by inserting one or more of the at least two pieces of the first graft into a space between the two lines of nasal dorsum and positioned in a ventral direction with respect to the second graft that is inserted into the nasal dorsum of the subject.

US Pat. No. 10,213,295

INTRAOCULAR LENS INSERTION APPARATUS

Kowa Company, Ltd., Nago...

1. An intraocular lens insertion apparatus, comprising:a cylindrical body member configured to retain an intraocular lens;
a fore-end opening comprising a fore-end area provided for a tip of the body member; and
a planate protrusion provided for a tip of the fore-end opening,
wherein an end surface of the fore-end area of the fore-end opening is an oblique surface which is oblique to a plane perpendicular to a central axis of the body member,
wherein the fore-end area comprises a pair of lateral walls which are parallel to each other across the central axis, wherein the pair of lateral walls is formed on a side of the fore-end area, and
wherein the planate protrusion is configured to extend from the fore-end area to a distal end of the intraocular lens insertion apparatus, wherein the planate protrusion does not comprise a lateral wall or a bottom surface, such that the planate protrusion is open on both lateral sides and a bottom side thereof,
wherein the fore-end opening further comprises a back-end area connected to the fore-end area, and the back-end area comprises a pair of lateral walls,
wherein the lateral walls of the fore-end area increases in height from the distal end thereof to the proximal end thereof at a first slope,
wherein the lateral walls of the back-end area increases in height from the distal end thereof to the proximal end thereof at a second slope, and
wherein the first slope is greater than the second slope.

US Pat. No. 10,213,294

APPARATUS FOR USE IN A SURGICAL PROCEDURE

KELLER MEDICAL, INC., St...

1. An apparatus for use in a surgical procedure, the apparatus comprising:a flexible sleeve comprising: a first end region and a second end region, the flexible sleeve being tapered such that a width of the second end region is relatively smaller than a width of the first end region; an interior surface that forms an interior cavity, the interior cavity being sized to receive a filled breast implant; and a dry lubricant on the interior surface, the dry lubricant being activatable by moisture,
wherein the flexible sleeve comprises indicia for cutting the flexible sleeve, the indicia indicating dimensions for accommodating different implant sizes, and
wherein the flexible sleeve is manipulatable such that, when the filled breast implant is positioned within the interior cavity, a manually applicable directional pressure causes the filled breast implant to extrude from the second end region.

US Pat. No. 10,213,293

LIGHTWEIGHT BREAST IMPLANT MATERIAL

1. A prosthetic implant, comprising a polymeric gel and a plurality of additives, wherein said additives have been surface treated prior to incorporation with said polymeric gel with a surface treatment comprising at least one of organofunctional silanes, organofunctional titanates, organofunctional zirconates or long chain fatty acids;wherein said additives comprise a plurality of micro-lumens, and wherein said micro-lumens are rigid and comprise ceramic or glass;
wherein said additives that have been surface treated prior to incorporation with said polymeric gel and said gel undergo a curing reaction to cross-link said surface treated additives to said gel; and wherein the composite material is suitable for implantation to the human body;
wherein if the implant is ruptured the gel will continue to cover the micro-lumens, such that the body would only be exposed to said gel.

US Pat. No. 10,213,292

HYBRID ANCHOR

1. A hybrid anchor comprising:a core body made of a material selected from the group consisting of biocomposite, bioabsorbable, osteoconductive, and biocompatible non-absorbable, the core body comprising:
a proximal end, a distal end, and a longitudinal axis extending therethrough;
an aperture formed near the distal end of the core body and transverse to the longitudinal axis of the core body, the aperture configured to receive a suture;
a force receiving member disposed at the proximal end of the core body, the force receiving member configured to engage an inserter and to receive an insertion force applied by the inserter to the core body;
a tip disposed at the distal end of the core body;
a stop disposed at the proximal end of the core body; and
an elongated member extending between the stop and the tip along the longitudinal axis of the core body; and
a wing assembly made of a polymer, the polymer being different and more flexible than the material of the core body, the wing assembly comprising:
a sleeve comprising a proximal end, a distal end, and a surface extending therebetween, the sleeve fitted around the elongated member of the core body such that a distal-most end of the sleeve engages the tip and a proximal-most end of the sleeve engages the stop, the distal end of the sleeve being proximal to the aperture and the stop resisting proximal movement of the wing assembly along the elongated member; and
a plurality of wings formed on diametrically opposing sides of the sleeve and extending outwardly from the surface of the sleeve at an angle towards the proximal end of the sleeve.

US Pat. No. 10,213,291

VASCULAR REPAIR DEVICES

Bolto Medical, Inc., Sun...

1. A stent graft, comprising:a) a graft sleeve having a proximal end, a distal end, a sleeve diameter and a major longitudinal axis;
b) a bare stent having struts defining distal apices and proximal apices, the struts connecting the distal and the proximal apices and having a bare stent amplitude defined as a distance extending along a longitudinal length of the stent graft, the bare stent having a relaxed diameter that is greater than the sleeve diameter, the distal apices of the bare stent being secured at the proximal end of the graft sleeve, and the proximal apices of the bare stent extending beyond the proximal end of the graft sleeve; and
c) at least one stent at the proximal end of the graft sleeve distal to the bare stent, the at least one stent including struts defining distal apices and proximal apices, the proximal apices being nested between adjacent distal apices of the bare stent, the at least one stent having an amplitude defined as a distance extending along the longitudinal length of the stent graft and the at least one stent having a relaxed diameter greater than that of the sleeve diameter and being secured along its entirety to the graft sleeve, wherein the amplitude of the at least one stent is less than that of the bare stent amplitude, whereby an outward radial force of the at least one stent against the graft sleeve at any given diameter of the stent graft is greater than that of the bare stent.

US Pat. No. 10,213,290

BRAIDED STENT AND METHOD OF MANUFACTURING A BRAIDED STENT

BOSTON SCIENTIFIC SCIMED,...

1. A method of manufacturing a stent, comprising:interweaving one or more filaments around a stent mandrel, the one or more filaments each including a cross-sectional profile having at least one flattened portion, wherein the one or more filaments each include a generally round cross-sectional profile modified to form the at least one flattened portion; and
positioning a flattened portion of a first filament portion of the one or more filaments facing a flattened portion of a second filament portion of the one or more filaments.

US Pat. No. 10,213,289

BRONCHOSCOPIC LUNG VOLUME REDUCTION VALVE

Boston Scientific Scimed,...

1. A one way valve for a biological flow passage, comprising:a braided structure extending longitudinally from a proximal end to a distal end, the braided structure movable from a constrained configuration to an expanded configuration so that, upon insertion of the braided structure in the biological flow passage, the braided structure is maintained in the expanded configuration, the braided structure including a constricted portion at the distal end thereof, the constricted portion closing off a channel of the braided structure to define a funnel shape which prevents flow towards the distal end;
a non porous coating extending over a portion of the braided structure to prevent passage of fluids through the braided structure; and
an anchoring portion extending distally from the distal end of the braided structure to anchor the braided structure within the biological flow passage.

US Pat. No. 10,213,288

DISTAL PROTECTION FILTER

CRUX BIOMEDICAL, INC., M...

1. A system for providing embolic protection, the system comprising:a first sheath having a longitudinal axis, a proximal end, a distal end and a lumen, the lumen configured to receive a guidewire;
a first distal protection filter attached to a distal portion of the first sheath, the first distal protection filter comprising a self-expanding frame with a slidable crossover point that defines a proximal loop and a distal loop, and a filter element attached to one of the proximal loop or distal loop of the self-expanding frame of the first distal protection filter, wherein the filter element extends to the crossover point;
a second sheath disposed about the longitudinal axis and having a proximal end, a distal end and a lumen, the second sheath disposed over the first sheath, wherein the distal end of the second sheath is located proximally the first distal protection filter;
a second distal protection filter attached to a distal portion of the second sheath, the second distal protection filter comprising a self-expanding frame with a slidable crossover point that defines a proximal loop and a distal loop, and a filter element attached to the proximal loop of the self-expanding frame of the second distal protection filter, wherein the crossover point is proximal to the filter element, wherein the proximal loops and the distal loops each includes a proximal end and a distal end; and
an outer sheath disposed over both the first sheath and the second sheath; and
wherein when deployed, the proximal loops, the distal loops, and the slidable crossover points of the first distal protection filter and the second distal protection filter are substantially positioned on a same side of a plane within which the longitudinal axis of the first sheath extends,
wherein when deployed, the proximal ends of the proximal loops and the distal ends of the distal loops are substantially near the longitudinal axis, the distal ends of the proximal loops and the proximal ends of the distal loops at the crossover points are substantially away from the longitudinal axis.

US Pat. No. 10,213,287

IMPLANTABLE SELF-CLEANING BLOOD FILTERS

VeoSource SA, Lausanne (...

1. A method for implanting a blood filter that includes a filter portion and an anchor portion, said filter portion including an elbow portion and an extension portion, said elbow portion depending from said anchor portion, said extension portion having a proximal end that defines a bypass aperture, said extension portion including a superior face that defines a first porosity and an inferior face opposite said superior face that defines a second porosity, said first porosity being greater than said second porosity, the method comprising:disposing said anchor portion in a first artery of an aortic arch;
orienting said filter portion so that said bypass aperture is in a downstream direction of a blood flow in said aortic arch; and
positioning said blood filter so that said superior face of said extension portion of said filter portion is in contact with a wall of said aortic arch.

US Pat. No. 10,213,286

IMPLANTABLE MEDICAL DEVICE AND METHODS OF DELIVERING THE IMPLANTABLE MEDICAL DEVICE

Boston Scientific Scimed,...

17. A medical device configured to be delivered and placed within a patient's body, the medical device comprising:a first elongate member having a proximal end portion and a distal end portion defining a longitudinal axis, the first elongate member being made of a synthetic material;
a second elongate member made of a biologic material, the second elongate member having a first portion and a second portion, the first portion of the second elongate member being attached to the first elongate member along its entire length of the first portion of the second elongate member, the length being in a direction along the longitudinal axis of the first elongate member, the second portion of the second elongate member being attached to the first portion of the second elongate member at a transverse edge of the first portion of the second elongate member, the second portion of the second elongate member configured to move with respect to the first portion of the second elongate member, wherein the second elongate member is configured to form a defined non-planar shape, and
a third elongate member made of a biologic material, the third elongate member being attached to the distal end portion of the first elongate member in a planar manner, wherein the third elongate member is configured to be non-movable with respect to the first elongate member.

US Pat. No. 10,213,285

INFLATABLE HERNIA PATCH

1. A medical implant for strengthening an intra-abdominal defect, the medical implant comprising:a mesh layer;
a fluid chamber to contain pressure therethroughout;
the fluid chamber forming at least one of a ring and a rib; and
the fluid chamber connected to the mesh layer wherein inflation of the fluid chamber deploys the medical implant by extending the mesh layer toward a planar configuration.

US Pat. No. 10,213,284

CORNER-LOCK STITCH PATTERNS

TELA Bio, Inc., Malvern,...

1. A method for sewing a corner-lock stitch pattern, comprising (a) sewing or embroidering a first upper thread or yarn and a first lower thread or yarn in a first pattern into a substrate material, the first pattern comprising one or more curves, one or more angles, or a combination of one or more curves and one or more angles, and (b) sewing or embroidering a second upper thread and a second lower thread in a second pattern into the substrate material, the second pattern comprising one or more curves, one or more angles, or a combination of one or more curves and one or more angles; wherein at least one of the one or more curves or the one or more angles of the second pattern overlaps at least one of the one or more curves or the one or more angles of the first pattern, and one or more of the overlaps comprises a corner-lock stitch pattern comprising one or more thread interlace points and two or more thread overlays in which the second upper thread and second lower thread envelope the first upper thread and first lower thread.

US Pat. No. 10,213,283

TEXTILE-BASED PROSTHESIS FOR LAPAROSCOPIC SURGERY

Sofradim Production, Tre...

1. A prosthesis intended to be conveyed to an implantation site with the aid of a trocar, comprising:at least one flexible biocompatible textile having two opposite faces and a shape defining a longitudinal axis, and
at least one reinforcing element for said textile, the reinforcing element comprising at least one semi-rigid elongate rod segment situated in a distal region of the textile, one or more oblique rod segments situated in a proximal region of the textile and a triangular frame arranged between the elongate rod segment and the oblique rod segment, the at least one semi-rigid elongate rod segment fixed to at least one face of the two opposite faces of the textile and extending substantially parallel to the longitudinal axis along the at least one face, the rod segment having a proximal end and a distal end, the distal end provided with at least one fastening element having a shape of a ring and distinct from the textile, the fastening element configured to cooperate with a part of a tool that is able to pass through the trocar, in order to temporarily couple the prosthesis to the tool, wherein the one or more oblique rod segments are situated proximally to the proximal end of the at least one rod segment.

US Pat. No. 10,213,282

IN VITRO PLATFORM AND METHODS FOR CULTURING EMBRYOS FOR IMPLANTATION

California Institute of T...

1. A method of identifying in vitro implantation of an isolated mammalian embryo derived from a donor uterus, the method comprising:adding the isolated mammalian embryo derived from the donor uterus at Carnegie Stage 2, 3, or 4 or an equivalent mammalian stage to a first suspension comprising collagen or fibrinogen to form a second suspension comprising the isolated mammalian embryo and the collagen or the fibrinogen;
polymerizing the second suspension to form a polymerized matrix comprising collagen fibers or fibrin fibers with the isolated mammalian embryo embedded therein; and
observing or detecting remodeling or aggregation of the collagen fibers or the fibrin fibers in the polymerized matrix as an indication of in vitro implantation of the isolated mammalian embryo.

US Pat. No. 10,213,281

NON-SURGICAL SYSTEMS AND METHODS FOR TREATING RECEDING GUMS

1. A system for non-surgical treatment of receding gums, comprising:a dental impression selected from the group consisting of a) an impression of upper teeth and surrounding gums and b) an impression of lower teeth and surrounding gums, wherein the dental impression comprises:
a tooth impression portion conforming to portions of teeth having receded gums;
a gum impression portion conforming to portions of remaining gums surrounding the teeth having receded gums; and
a void portion configured to define a void extending along the teeth having receded gums and defining an area into which growth of the remaining gums is desired;
wherein the dental impression further comprises a vacuum channel extending along an inner surface off the dental impression to facilitate delivery of a vacuum force from a vacuum source to the void portion of the dental impression.

US Pat. No. 10,213,280

AUTOMATED METHOD OF MANUFACTURING ORAL APPLIANCES

ProSomnus Sleep Technolog...

1. A method of manufacturing an oral appliance, the method comprising the steps of:a) preparing a three-dimensional electronic model of a patient's dentition;
b) subtracting the three-dimensional electronic model of the patient's dentition from an image of a solid block to obtain an appliance data set;
c) determining a contour curve for the dentition, wherein the contour curve is placed at an offset distance at either the buccal or lingual side of the dentition, wherein the offset distance is a fraction of a visible buccal or lingual height of one of the posterior-most molars; and
d) manufacturing a dental appliance in accordance with the appliance data set and the contour curve.

US Pat. No. 10,213,279

DENTURE FIXING ATTACHMENT

1. A denture-fixing attachment for freely connecting a denture to a fixture implanted into an alveolar bone in a slanted direction by adjusting a denture angle of the denture with respect to the fixture, the denture-fixing attachment comprising:a rod-shaped joint member having an upper end for supporting the denture fixed thereto and a locking protruding portion protruding laterally from a lower portion of the joint member; and
an abutment having a coupling portion formed in an outer surface of a lower portion thereof so as to be coupled to a fixture recess formed in the fixture, and a receiving portion formed in an upper portion thereof so as to receive the lower portion of the joint member therein,
wherein the receiving portion of the abutment includes a receiving recess for receiving the lower portion of the joint member inserted thereinto, and a stop protruding portion provided in the receiving portion above the receiving recess and having a guide groove disposed adjacent to the stop protruding portion for guiding coupling movement of the locking protruding portion fitted thereinto,
wherein the guide groove includes a first guide groove part formed in a vertical direction, a second guide groove part formed at an end of the first guide groove part in a horizontal direction, and a third guide groove part formed at an end of the second guide groove part in the vertical direction, and wherein a bottom end of the vertical third guide groove part is open downward along the vertical direction at a distal end thereof, such that the locking protruding portion moves through and out of the guide groove and into the receiving recess as the joint member is inserted thereinto.

US Pat. No. 10,213,278

METHOD AND TOOLS FOR INDIRECT BRACKET POSITIONING

1. A positive tooth model, comprising: a model tooth; a model gum attached to the model tooth; a partial mock bracket attached to the model tooth; and a place holder, whereinthe partial mock bracket comprises a fully formed distal tie wing and no proximal tie wing;
the place holder replaces the proximal tie wing of the partial mock bracket and extends in a form of a rod or protrusion in a perpendicular direction starting from a horizontal median of the partial mock bracket to the gum of the tooth model.

US Pat. No. 10,213,277

DENTAL APPLIANCE BINDING STRUCTURE

Align Technology, Inc., ...

1. A removable dental appliance system, comprising:a first shell including:
a number of tooth apertures configured to receive a number of teeth of a patient's first jaw, at least one tooth aperture of the number of tooth apertures having an interior surface configured to apply an orthodontic repositioning force to reposition one or more teeth of the number of teeth; and
a first binding structure integrally formed with the first shell, the first binding structure including:
a first binding surface on the outer occlusal surface of the appliance, the first binding surface configured to mate with a first portion of an attachment surface of a first mandibular advancement feature; and
a second binding surface on the outer buccal surface of the appliance, the second binding surface configured to mate with a second portion of the attachment surface of the first mandibular advancement feature, wherein the first mandibular advancement feature is adhesively coupled to the first binding surface and the second binding surface with a flexible adhesive that substantially allows movement of the first mandibular advancement feature relative to the first binding surface and the second binding surface.

US Pat. No. 10,213,276

INSERT FOR ULTRASONIC BURR-DRILL UNIT

SOCIETE POUR LA CONCEPTIO...

1. An ultrasonic dental scaler appliance, comprising: at least one surgical handpiece connected to an ultrasound generator and at least one interchangeable ultrasound tip selectively mounted on the surgical handpiece, the tip consisting of:a first, treatment end having a distal end;
a second, base end having a bottom end configured to be selectively mounted on the surgical handpiece; and
at least one cavity forming a housing provided in the base end at a predetermined distance from the bottom end, such that the at least one cavity is located nearer the bottom end of the tip than the distal end, so as to project beyond the handpiece when the tip is mounted thereon so as to remain visible when the tip is mounted on the handpiece and during use thereof;
wherein the tip is monolithically formed, and an identifier element is received within the housing, the identifier element made of an elastic material that has a melting temperature higher than 130° C.

US Pat. No. 10,213,275

CUSTOM LINKABLE IMAGING AND MULTIFUNCTIONAL TRAY

IBUR, LLC, Troy, MI (US)...

1. A dental tray comprising:a clasping portion defining a receiving cavity configured to receive at least one oral structure having two opposing outer lateral surfaces and an upper surface disposed therebetween, the clasping portion comprising:
opposing lateral bands unitary with the clasping portion;
a top portion defined therebetween;
at least one rest unitary with the clasping portion and permanently extending away from the top portion into the receiving cavity, the rest shaped and configured to assist in stabilizing the tray;
a lateral contact unitary with the clasping portion and extending away from each of the lateral bands into the receiving cavity;
the receiving cavity defining an open space between both the upper surface and the outer surfaces of the received at least one oral structure;
wherein the top portion is configured to be spaced away from the upper surface of the oral structure with the at least one rest configured to selectively engage the upper surface to facilitate a tight and secure engagement between the clasping portion and the received at least one oral structure;
wherein the lateral contacts selectively engage at least one of the outer surfaces of the received at least one oral structure to facilitate a tight and secure engagement between the clasping portion and the received at least one oral structure; and
wherein the orientation of the at least one rest and the lateral contacts ensures that a majority of the received oral structure positioned within the receiving cavity of the dental tray is free from engagement with any element of the dental tray.

US Pat. No. 10,213,274

METHOD OF TRACKING AND NAVIGATION FOR A DENTAL INSTRUMENT

King Saud University, Ri...

1. A method of tracking and navigation for a dental instrument to assist a dental practitioner during a procedure on a patient with the aid of a computer system, comprising the steps of:establishing a fixed set of spatiotemporal marker tensors for the patient, Tj, where j=1, . . . , M;
producing a tomographic image of an area of interest of the patient, wherein the tomographic image is configured to be displayed to the dental practitioner;
providing the computer system, wherein the computer system includes at least a memory and a processor;
positioning a plurality of patient tracking markers on the patient in the area of interest, wherein the step of positioning the plurality of patient tracking markers on the patient in the area of interest comprises positioning a plurality of active and passive patient tracking markers on the patient in the area of interest;
positioning a plurality of instrument tracking markers on a dental instrument, wherein the step of positioning the plurality of instrument tracking markers on the dental instrument comprises positioning a plurality of active and passive instrument tracking markers on the dental instrument and defining visual sensors, M being a combined number of the positioned patient and instrument tracking markers;
providing the computer system, wherein the computer system includes at least a memory and a processor configured to perform the steps of:
a) establishing a set of spatiotemporal sensor tensors, Ih, where h=1, . . . , K, K being a number of visual sensors deployed for detecting the patient and instrument tracking markers, wherein the deployed visual sensors define a sensor array;
b) performing singular value decomposition on each of the spatiotemporal marker tensors to produce a corresponding pair of orthogonal tensors, and , and a corresponding singular values diagonal tensor, , where (a, b, c) represents a point in the diagonal tensor corresponding to a set of three-dimensional indices, (a, b, c);
c) calculating an lth feature space basis, BF(l), as BF(l)=[(a+r1u, b+r2u, c+r3u)|(a+r1v, b+r2v, c+r3v)], where l=1, . . . , L, and where L represents a total number of feature space bases, r1u, r2u, r3u, r1v, r2v, r3v are each predetermined ranges of values, and (a, b, c) is greater than a first threshold value, Threshold1;
d) calculating an lth extracted feature tensor, Fh(l), as Fh(l)=Ih*BF(l), wherein l=1, . . . , L and h=1, . . . , K;
e) calculating an lth saliency map, SMh(l) for each extracted feature tensor, Fh(l) as SMh(l)=FFT2{|FFT2{FFT2{Fh(l)(t)}}|}, where l=1, . . . , L and h=1, . . . ,K, and FFT2 represents a two-dimensional fast Fourier transform;
f) calculating an lth uncertainty map, UMh(l) for each saliency map, SMh(l) as UMh(l)=UMh(l)=SMh(l)?P[SMh(l)(a, b, c)>Threshold2|{I1,I2, . . . ,IK},{T1,T2, . . . , TM}], where P[.] represents a probability of a pixel (a, b, c) of the saliency map SMh(l) being above a second threshold value, Threshold2;
g) calculating a fused saliency map, FSM, as

h) calculating a binary fused map, FSMb, as FSMb=FSM when FSM is greater than a third threshold value, Threshold3; and
i) constantly providing the computer system with the results of each of the calculations and repetitively recalculating the location of the dental instrument;
overlaying the binary fused map on the tomographic image to provide visual feedback of the dental instrument relative to the area of interest of the patient on a display; and
repetitively returning to the step of performing singular value decomposition on each of the spatiotemporal marker tensors, wherein distance between the spatiotemporal marker tensors can then be computed by recalculating the point in the diagonal tensor S corresponding to a set of three-dimensional indices, (a, b, c).

US Pat. No. 10,213,273

DRILL LIMIT SYSTEM AND METHOD OF USING SAME

Implant Direct Sybron Int...

1. A drill limit system for providing a drill stop with a drill bit, comprising:a holder including at least one drill stop positioned on the holder and configured to receive at least one drill bit therethrough, wherein the at least one drill stop has a first state in which the at least one drill bit is configured to be movable relative to the at least one drill stop and a second state in which the at least one drill stop is configured to be secured to the at least one drill bit; and
a platform operatively coupled to the holder and having a surface configured to engage a tip end of the at least one drill bit,
wherein the holder and the platform are movable relative to each other such that the position of the at least one drill stop relative to the at least one drill bit may be selectively varied in order to locate the at least one drill stop at a desired position on the at least one drill bit, wherein the platform is configured to be vertically stationary and the holder is configured to be movable relative to the platform, and wherein rotation of the holder causes vertical movement of the holder relative to the platform.

US Pat. No. 10,213,272

PIEZOELECTRIC DEVICE AND CIRCUITRY

INTER-MED, INC., Racine,...

1. A device, comprising:a circuit, comprising:
at least one boost converter configured to receive power from an energy source;
a square wave driver configured to receive power from the boost converter and to generate a high voltage square wave;
a distally mounted piezoelectric transducer driven by the square wave driver, and connectable to a load;
first and second grounded diodes arranged back-to-back and configured in parallel with each other, the diodes connected in series with the transducer and arranged to form a junction between the transducer and ground; and
a voltage comparator having a first input connected to the junction, and an output that indicates phase of current through the transducer as a voltage; and
coupled to the circuit, a phase-locked loop in a feedback loop, the phase-locked loop comprising a low pass filter, a voltage-controlled oscillator (VCO), and a phase comparator having a first input for receiving from the VCO a voltage that indicates a drive voltage phase and having a second input for receiving the voltage comparator output voltage,
whereby when the transducer is connected to the load the phase-locked loop synchronizes the current phase and the drive voltage phase to determine a resonance frequency of the transducer.

US Pat. No. 10,213,271

ILLUMINATING SURGICAL DEVICE AND CONTROL ELEMENT

Illumix Surgical Canada I...

1. An illuminating surgical device, comprising:a two-dimensional array of illuminating elements to direct light toward a surgical field; and
a single control element to control an intensity of light from the two-dimensional array of illuminating elements and to control placement of the illuminated surgical field, wherein movement of the single control element along a first axis is to control a direction of light from the two-dimensional array of illuminating elements parallel to the first axis, and wherein movement of the single control element along the first axis is to control a plurality of louvers, the plurality of louvers to control the direction of the light from the two-dimensional array of illuminating elements.

US Pat. No. 10,213,270

SMALL DISPOSABLE TORQUE LIMITING DRIVING TOOL WITH RUBBER GRIP

Lomack Industrial Co. Ltd...

1. A self-limiting torque applying tool, comprising:a hollow housing including a grip surface, a longitudinal central axis, a proximal end, a distal end, and a cap rotatably engageable with the proximal end;
a working shaft drivingly coupled to the hollow housing and rotatable relative to the hollow housing about the longitudinal central axis;
a torque limiting clutch operably between the working shaft and the hollow housing, the torque limiting clutch configured to enable transmission of torque from the hollow housing to the working shaft while limiting maximum transmitted torque to a predetermined value;
a torque adjuster operable to adjust the maximum transmitted torque to the predetermined value; and
an adjusted torque sensing feature contained within the hollow housing.

US Pat. No. 10,213,269

DEPTH LIMITER FOR SUTURING DEVICES AND METHODS THEREOF

LSI Solutions, Inc., Vic...

1. A depth limiter for surgical suturing, comprising:a tissue stop;
at least one attachment point coupled to the tissue stop and configured to removably engage a surgical suturing device to position the tissue stop relative to a tissue bite area of the surgical suturing device;
wherein the at least one attachment point comprises a shaft clip; and
the shaft clip is configured to extend at least 180 degrees around a shaft of the surgical suturing device which the at least one attachment point is configured to removably engage.

US Pat. No. 10,213,268

LATCH RELEASE FOR SURGICAL INSTRUMENT

Intuitive Surgical Operat...

1. A surgical instrument that includes a proximal control mechanism, the proximal control mechanism comprising:an instrument control surface on an outer surface of the proximal control mechanism, the instrument control surface including a first opening and a second opening; a fixed latch structure contained within the proximal control mechanism, the fixed latch structure including a first lead-in ramp adjacent the first opening and a second lead-in ramp adjacent the second opening, the first lead-in ramp leading to a first locking surface of the fixed latch structure, the second lead-in ramp leading to a second locking surface of the fixed latch structure: and two latch release members, each latch release member including a button portion and a latch arm engaging portion extending from the button portion parallel to the instrument control surface, the two latch release members arranged such that moving the two button portions toward each other parallel to the instrument control surface causes the two latch arm engaging portions to move away from one another and release latch arms from the first and second locking surfaces.

US Pat. No. 10,213,267

SURGICAL DRAPE WITH CONTROL MECHANISM

Tenet Medical Engineering...

12. A method of activating a surgical instrument from a point within a sterile field during a surgical procedure, wherein the surgical instrument is located outside of the sterile field, comprising the steps of:a) providing a surgical drape including a tubular main body having an open proximal end, a distal end, and a longitudinal axis extending between the proximal and distal ends, the main body configured for passage of a surgical instrument through the open proximal end along the longitudinal axis of the main body, a dam portion attached to the distal end of the main body, the dam portion comprising a material selected to be different than a material of the main body, and a control mechanism attached to an outer surface of the main body between the proximal and distal ends, the control mechanism comprising an electrical switch completing an electrical connection on the sterile side for activating the surgical instrument and including a communication interface for interfacing with the surgical instrument;
b) covering the surgical instrument with the surgical drape to define the sterile field externally to the surgical drape;
c) enabling the communication interface so that the communication interface is capable of sending electrical control signals across a sterile barrier defined by the surgical drape to the surgical instrument; and
d) activating, on a sterile side of the surgical drape within the sterile field, the control mechanism to activate the surgical instrument, the activation performing an electrical activation responsive to a mechanical activation of the control mechanism, the mechanical activation and the electrical activation occurring on the sterile side of the barrier,
wherein the electrical switch is attached to a backing sheet that is releasably attached to a release sheet on the outer surface of the main body and wherein the backing sheet may be removed from the release sheet and releasably attached to another surface in the sterile field; and
wherein an opening formed at a distal terminus of the dam portion along the longitudinal axis is configured to permit passage therethrough of an operative arm of the surgical instrument for engaging a patient's limb or other surgical instrument.

US Pat. No. 10,213,266

ROBOTIC SURGICAL ASSEMBLIES AND ADAPTER ASSEMBLIES THEREOF

Covidien LP, Mansfield, ...

1. A torque transducer for mounting a motor, comprising:a mounting flange configured to secure the torque transducer to a fixed structure;
a motor flange configured to secure to a motor;
a body interconnecting the mounting and motor flanges, the body defining a channel about a longitudinal axis of the body, the body configured to flex in response to the mounting flange and the motor flange rotating relative to one another in response to torque of the motor; and
a strain gauge positioned on the body to measure flexation of the body.

US Pat. No. 10,213,265

MANIPULATOR AND MANIPULATOR SYSTEM

OLYMPUS CORPORATION, Tok...

1. A manipulator comprising:a main unit provided on a proximal end of the manipulator;
an elongated portion configured to extend from the main unit;
a distal end of the elongated portion, the distal end configured to bend or flex with respect to the elongated portion;
a wire coupled to the main unit and the distal end;
wherein the main unit comprises:
a drive unit configured to generate driving power to bend or flex the distal end,
a rotary unit comprising:
a shaft member configured to be rotated by the driving power,
a disc member mounted on an outer periphery of the shaft member, and
a peripheral wall mounted on the disc member along the circumference of the disc member,
an elastic unit located along an outer peripheral surface of the peripheral wall,
a first lock portion configured to lock one end of the elastic unit to the rotary unit, and wherein the wire connects the elastic portion and is wound along the peripheral wall, and the wire is configured to transmit the driving power.

US Pat. No. 10,213,264

CATHETER TENSION SENSING

Auris Health, Inc., Redw...

1. A robotic surgical system, comprising:an elongate member comprising a pull wire disposed therein;
an input device configured to receive a user input;
an instrument driver operatively coupled to the elongate member, the instrument driver comprising a motor and a rotary torque sensor configured to generate torque data indicative of a torque imparted on the pull wire; and
a control system operatively coupled to the input device and the instrument driver, wherein the elongate member is controllable by the instrument driver based on a command generated by the control system in response to the user input and the torque data.

US Pat. No. 10,213,263

FLEXIBLE-MANIPULATOR GUIDE MEMBER AND FLEXIBLE MANIPULATOR

OLYMPUS CORPORATION, Tok...

1. A manipulator comprising:a guide extending along a longitudinal axis, wherein the guide comprises:
a lumen inner surface configured to define a lumen extending along the longitudinal axis of the guide,
wherein the lumen comprises a first portion and a second portion along the longitudinal axis, and
wherein at least the first portion of the lumen has a spiral-shape extending along the longitudinal axis; and
a wire arranged within the lumen defined by the lumen inner surface,
wherein the wire is configured to transmit a driving force generated by an actuator to a movable structure, and
wherein the lumen inner surface is configured such that:
a path length of the lumen per unit length of the guide along the longitudinal axis in the first portion of the lumen is different from a path length of the lumen per unit length of the guide along the longitudinal axis in the second portion of the lumen.

US Pat. No. 10,213,262

MANIPULATABLE SURGICAL SYSTEMS WITH SELECTIVELY ARTICULATABLE FASTENING DEVICE

Ethicon LLC, Guaynabo, P...

1. A surgical system, comprising:a first rotary output member;
a second rotary output member;
a third rotary output member;
a surgical end effector, comprising:
a first jaw and a second jaw, wherein one of said first and second jaws is movable relative to the other of said first and second jaws between open and closed positions upon application of jaw control motions thereto and wherein one of said first and second jaws comprises a surgical staple cartridge; and
a firing member axially movable between a starting position and an ending position within said first and second jaws, said firing member configured to axially pass through said first and second jaws to eject surgical staples housed within said surgical staple cartridge and wherein said surgical system further comprises:
an elongate shaft assembly defining a longitudinal tool axis and operably coupled to said surgical end effector to facilitate selective articulation of said surgical end effector relative to said longitudinal tool axis, said elongate shaft assembly comprising:
a plurality of articulation members movably supported by said elongate shaft assembly and operably interfacing with said surgical end effector; and
a firing shaft operably interfacing with said firing member to apply a firing motion thereto and wherein said surgical system further comprises:
an articulation transmission operably interfacing with said first rotary output member and said plurality of articulation members such that rotation of said first rotary output member applies articulation motions to said plurality of articulation members;
a firing drive member operably coupled to said firing shaft and being configured to interface with said second rotary output member to apply firing control motion to said firing shaft; and
a closure clutch assembly operably interfacing with said elongate shaft assembly and said third rotary output member to receive a third rotary output motion therefrom to thereby selectively axially advance at least a portion of said elongate shaft assembly along said longitudinal tool axis to apply said jaw control motions to at least one of said first and second jaws.

US Pat. No. 10,213,261

EXTERNAL FIXATOR DEFORMITY CORRECTION SYSTEMS AND METHODS

Stryker European Holdings...

1. A computer-implemented method comprising employing at least one processor to execute instructions to:generate a display of an ellipse superimposed on a display of at least one digital medical image, the at least one digital medical image displaying a representation of a patient's anatomical structure, the ellipse being a graphical representation of a ring of a synthetic external fixator representing a physical external fixator attachable to the patient's anatomical structure, the physical external fixator comprising at least two rings interconnected by a plurality of struts;
receive strut attachment point user input representing actual or planned points of attachment of the plurality of struts to the at least two rings of the physical external fixator, wherein a selected one of the plurality of struts is coupled or is planned to be coupled to a selected one of the at least two rings via an intermediary piece of hardware; and
generate a bone deformity correction plan specifying for each strut a sequence of strut lengths to be used in a bone deformity correction treatment.

US Pat. No. 10,213,260

END FIRE FIBER ARRANGEMENTS WITH IMPROVED EROSION RESISTANCE

1. An arrangement for delivering treatment radiation to tissues situated laterally of an optical fiber through which the treatment radiation is delivered, comprising:a protective ferrule surrounding and enclosing a treatment end of an optical fiber adjustably positioned within the protective ferrule; and
a cannula in which the optical fiber and protective ferrule are mounted, wherein:
treatment radiation is emitted axially from an end of the optical fiber through the protective ferrule,
the cannula has a pre-formed curvature,
the curvature of the cannula is assumed by the optical fiber mounted therein to cause treatment radiation emitted axially through an end of the fiber to be directed laterally at tissues situated to a side of the fiber, and
the cannula has sufficient flexibility to enable the cannula and fiber to straighten when withdrawn into a straight working channel of a scope, the cannula and fiber returning to the pre-formed curvature when extended out of the working channel.

US Pat. No. 10,213,259

MEDICAL LASER TREATMENT DEVICE AND METHOD FOR OPERATING SAME

LUTRONIC CORPORATION, Go...

1. A method of operating a medical laser treatment device, which includes a body having a laser generator and a handpiece connected to the body, the method comprising:(a) contacting skin of a patient with the handpiece;
(b) pressing a portion of a blood vessel by pressing a first area of the skin with the handpiece so as to expand a portion of the blood vessel, the pressed portion of the blood vessel being located under the first area of the skin, the expanded portion of the blood vessel being located upstream of the pressed portion of the blood vessel; and
(c) irridiating a laser into a second area of the skin under which the expanded portion of the blood vessel is located by operating the laser generator in the body,
wherein the medical laser treatment device further comprises a laser tip detachably coupled to the handpiece, the laser tip including a guide body that has a specific shape, the specific shape defining the second area of the skin into which the laser irradiates.

US Pat. No. 10,213,258

MEDICAL LASER SYSTEM

Lymol Medical, Inc., Wob...

1. A medical laser system, comprising:a crystal-based laser;
a pointer laser;
a power supply for powering the crystal-based laser and the pointer laser;
a controller operably connected to the crystal-based laser, the pointer laser, and the power supply; and
a memory operably connected to the controller;
wherein the controller is programmed to:
(a) selectively activate the crystal-based laser to cause a laser light emission by adjustably controlling power supplied by the power supply to the crystal-based laser responsive to a user activation input;
(b) selectively activate the pointer laser to cause a pointer laser light emission by adjustably controlling power supplied by the power supply to the pointer laser responsive to a user activation input; and
(c) record data in the memory in connection with treatment of a patient, said data indicating the total exposure of the patient to radiation emitted by the crystal-based laser and the pointer laser during activation thereof.

US Pat. No. 10,213,257

DEVICES AND METHODS FOR OPTICAL DETECTION OF TISSUE CONTACT

COVIDIEN LP, Mansfield, ...

1. A method of directing energy to tissue, comprising:positioning an energy applicator for delivery of energy to target tissue, the energy applicator operably associated with an electrosurgical power generating source and having a waveguide, the waveguide including electrically conductive walls that define a cavity therein and a plurality of dielectric layers disposed coaxially with a longitudinal axis defined by the cavity;
generating optical signals from the energy applicator;
determining a position of the energy applicator relative to the target tissue based on a reflection of the generated optical signals; and
transmitting energy to the target tissue via the waveguide based on the determination of the position of the energy applicator relative to the target tissue.

US Pat. No. 10,213,256

SYSTEM AND METHOD FOR MONITORING ABLATION SIZE

COVIDIEN LP, Mansfield, ...

1. A method for monitoring ablation size, the method comprising:transmitting microwave energy from a power source to a microwave antenna to form a tissue ablation zone;
measuring near field electromagnetic radiation emitted from the microwave antenna at a resonator coupled to the microwave antenna;
transmitting a detection signal corresponding to the measured near field electromagnetic radiation to the power source; and
adjusting at least one property of the microwave energy from the power source to the microwave antenna based on the detection signal.

US Pat. No. 10,213,255

ELECTROSURGICAL DEVICES HAVING DIELECTRIC LOADED COAXIAL APERTURE WITH DISTALLY POSITIONED RESONANT STRUCTURE AND METHOD OF MANUFACTURING SAME

COVIDIEN LP, Mansfield, ...

1. An electrosurgical device for delivering energy to tissue, comprising:an antenna assembly defining a longitudinal axis and including a dielectric sleeve, the dielectric sleeve including:
a first dielectric segment; and
a second dielectric segment configured to be coupled to the first dielectric segment about the longitudinal axis of the antenna assembly, the first and second dielectric segments cooperatively defining a longitudinal channel extending along the longitudinal axis; and
a feedline including a dielectric material surrounding an inner conductor, the inner conductor including a distal portion disposed distally beyond the dielectric material, the distal portion of the inner conductor disposed within the channel defined by the first and second dielectric segments.

US Pat. No. 10,213,254

CATHETER WITH LIQUID-COOLED CONTROL HANDLE

Biosense Webster, Inc., ...

1. An electrophysiologic catheter, comprising:a catheter body;
a control handle proximal the catheter body, the control handle housing a printed circuit board on which is mounted one or more integrated circuits; and
a heat transfer assembly including:
a pump,
a reservoir containing a coolant,
a cooling unit configured to cool the coolant,
a heat transfer member within the control handle and mounted on the printed circuit board, and
a coolant transport network providing coolant communication between at least the reservoir or cooling unit and the heat transfer member mounted on the printed circuit board.

US Pat. No. 10,213,253

ESTIMATING A TEMPERATURE DURING ABLATION

Biosense Webster (Israel)...

1. A method for use with an intra-body probe, a distal end of which includes an ablation electrode and a temperature sensor, the method comprising, using a processor:while (i) the ablation electrode is driving an ablating current into tissue of a subject, and (ii) fluid is passed from the distal end of the intra-body probe at a fluid-flow rate, receiving a temperature sensed by the temperature sensor;
estimating a temperature of the tissue, based at least on the sensed temperature and at least one parameter selected from the group consisting of: the fluid-flow rate, and a parameter of the ablating current, comprising selecting a coefficient in response to the at least one parameter, and estimating the temperature of the tissue, at least by multiplying, by the coefficient, a value that is based on the sensed temperature; and
generating an output in response to the estimated temperature.

US Pat. No. 10,213,252

INDUCING DESIRABLE TEMPERATURE EFFECTS ON BODY TISSUE

Vessix, Inc., Laguna Hil...

1. A system for remodeling tissue disposed about a blood vessel, the system comprising:an endovascular catheter having an energy delivery portion adapted to be coupled with a target tissue, wherein the catheter includes a balloon, wherein the energy delivery portion comprises a plurality of electrodes disposed about the balloon of the catheter so as to define a plurality of remodeling zones in the target tissue when the balloon is in contact with a blood vessel wall disposed adjacent to the target tissue; and
an energy source coupleable with the catheter, the energy source being configured to deliver a controlled quantity of energy to each of the plurality of electrodes in response to an input such that the controlled quantity of energy heats at least some of the plurality of remodeling zones of the target tissue so as to remodel the target tissue and inhibit thermal damage of collateral healthy tissues;
wherein the plurality of remodeling zones includes a first remodeling zone and a second remodeling zone disposed adjacent to the first remodeling zone and wherein the plurality of electrodes comprise a plurality of bipolar electrode pairs spaced around an axis of the balloon so that the plurality of remodeling zones defined by the bipolar electrode pairs are laterally separated from each other so as to form gaps between the first remodeling zone and the second remodeling zone;
wherein the energy source includes a processor, wherein the processor is designed to determine a frequency or range of frequencies at which a first impedance of the target tissue is equal to or greater than a second impedance of the collateral healthy tissue; and wherein the processor is configured to deliver the controlled quantity of energy delivered to the plurality of electrodes at the frequency or range of frequencies.

US Pat. No. 10,213,251

HIGH-FREQUENCY TREATMENT TOOL

SUMITOMO BAKELITE COMPANY...

1. A high-frequency treatment tool comprising:a flexible tube configured to be inserted into a body cavity;
an operating wire configured to be inserted through the flexible tube so as to be movable back and forth;
a treatment part arranged on a distal end of the operating wire and configured to treat biological tissue by applying a high-frequency current;
a main body configured to rotatably connect to a base end of the flexible tube;
a terminal part rotatably coupled to the main body and including a power supply terminal to which a power cord configured to supply electric power to the treatment part is detachably connected;
a main body-operating part unrotatably coupled to the main body and configured to be gripped when a user rotates the main body;
a slider-fixing part configured to fix a base end of the operating wire guided from the base end of the flexible tube and slide the operating wire in an axis direction with respect to the main body; and
a slider-gripping part configured to encircle at least a portion of an outer peripheral surface of the slider-fixing part and slide the slider-fixing part by the operation of the user,
wherein the slider-fixing part is unrotatably coupled to the main body and the slider-gripping part is rotatably coupled to the slider-fixing part,
the operating wire is configured to be fixed inside the main body, such that rotation of the main body causes the operation wire to rotate inside the flexible tube, and
the terminal part is coupled to an end of the main body, which is distal to the main body-operating part and the slider-gripping part.

US Pat. No. 10,213,250

DEPLOYMENT AND SAFETY MECHANISMS FOR SURGICAL INSTRUMENTS

COVIDIEN LP, Mansfield, ...

1. A surgical instrument, comprising:first and second members, at least one of the members movable relative to the other between a spaced-apart position and an approximated position;
a deployable component movable between a retracted position and an extended position; and
a trigger assembly, including:
a trigger portion engaged with the first member, the trigger portion including a trigger configured to move relative to the first member between an un-actuated position and an actuated position;
a linkage portion engaged with the second member and having the deployable component engaged thereto, the linkage portion movable between a first position and a second position for moving the deployable component between the retracted position and the extended position;
a pinion configured to rotate to convert movement of the trigger into movement of the linkage portion when the trigger portion and the linkage portion are engaged to one another, wherein the trigger portion further includes a first gear rack engaged to the trigger and disposed in meshed engagement with the pinion such that movement of the trigger effects rotation of the pinion,
wherein, in the spaced-apart position of the members, the trigger portion and the linkage portion are disengaged from one another such that movement of the trigger between the un-actuated position and the actuated position does not effect movement of the deployable component, and
wherein, upon movement of the first and second members to the approximated position, the trigger portion and the linkage portion are moved into engagement with one another such that movement of the trigger between the un-actuated position and the actuated position effects movement of the linkage portion between the first and second positions to thereby effect movement of the deployable component between the retracted and extended positions.

US Pat. No. 10,213,249

ELECTROSURGERY HANDPIECE/PENCIL WITH SMOKE EVACUATION

I.C. Medical, Inc., Phoe...

1. An electrosurgery pencil comprising:a hollow tubular handpiece member having a first end and a second end;
a planar platform located near a top of the hollow tubular handpiece member having a first opening traversing through the planar platform and into an interior of the hollow tubular handpiece member where the first opening is located near the first end of the hollow tubular handpiece member;
an electrode positioned within the first end of the hollow tubular handpiece member;
a circuit board seated on said planar platform;
at least one wire passing through the first opening in the planar platform for connecting the circuit board to the electrode;
an electrical cord containing one or more insulated wires for connecting said circuit board to an energy source; and
one or more depressable button members positioned above said circuit board for enabling selective contact with said circuit board.

US Pat. No. 10,213,248

ADAPTIVE ELECTRODE FOR BI-POLAR ABLATION

BIOSENSE WEBSTER (ISRAEL)...

1. An ablation apparatus, comprising: a first flexible probe adapted for insertion into a heart of a living subject and having a distal segment and a first ablation electrode disposed at the distal segment to be brought to a target tissue at a first side of a wall of the heart; a second flexible probe adapted for insertion into the living subject and having a distal end and a second ablation electrode disposed at the distal end, the second ablation electrode to be brought to an opposing second side of the wall to oppose the first ablation electrode, the second ablation electrode comprising a plurality of segments, the segments being concentric and electrically insulated from one another; and a power generator connectable to the first ablation electrode and switchably connectable to selected ones of the segments of the second ablation electrode for passing electric current from the first ablation electrode and through the target tissue and for passing electric current from the selected segments of the second ablation electrode and through the tissue, the first ablation electrode having a fixed current transmission area and the second ablation electrode having a variable current transmission area, the variable current transmission area being selected to form a transmural lesion between the first ablation electrode and the second ablation electrode.

US Pat. No. 10,213,247

THERMAL RESECTING LOOP

Domain Surgical, Inc., S...

1. A thermal resecting instrument, comprising:a thermal element comprising:
a conductor loop having a curved portion; and
a ferromagnetic coating covering at least the curved portion of the conductor loop, the ferromagnetic coating extending directly from a first end to a second end and forming a ferromagnetic region disposed along the conductor loop, the ferromagnetic region having a curvature between the first end and the second end that defines at least a part of an opening for receiving tissue, the conductor loop extending from a first position spaced apart from the first end of the ferromagnetic coating, through the ferromagnetic region and to a second position spaced apart from the second end of the ferromagnetic coating;
wherein, in use, the ferromagnetic coating is responsive to passage of electrical energy through the conductor loop to produce heat.

US Pat. No. 10,213,246

TISSUE ABLATION SYSTEMS AND METHOD

Hermes Innovations LLC, ...

1. A method of delivering electrosurgical energy to targeted tissue, said method comprising:providing a gas-filled chamber surrounded by a thin-walled dielectric barrier;
engaging an exterior of the gas-filled chamber against the targeted tissue;
coupling an RF current source between an electrode within the gas-filled chamber and the targeted tissue to initiate high-voltage, alternating current, gaseous discharges within the gas-filled chamber to deliver the current from the current source to the targeted tissue.

US Pat. No. 10,213,245

CONTINUOUS FLOW BALLOON CATHETER SYSTEMS AND METHODS OF USE

PAVmed Inc., New York, N...

1. A system for balloon inflation, the system comprising:a catheter having an inflow lumen and an outflow lumen;
a balloon positioned at a distal end of the catheter, the balloon being in fluid communication with the inflow and the outflow lumen; and
an infusion device having an inflow chamber in fluid communication with the balloon via the inflow lumen, and having an outflow chamber in fluid communication with the balloon via the outflow lumen, the infusion device configured for simultaneously circulating a fluid into and out of the balloon via the inflow lumen and the outflow lumen, respectively, at matching flow rates in order to keep the balloon volume and pressure constant during an entire infusion.

US Pat. No. 10,213,244

CRYOGENIC NEEDLE WITH FREEZE ZONE REGULATION

Myoscience, Inc., Fremon...

1. A system comprising:a controller;
a cooling supply system having a valve controlled by the controller; and
a needle probe coupled to the controller and configured to receive coolant from the coolant supply system, the needle probe having at least one needle and a heater thermally coupled to the at least one needle;
wherein the controller is configured to:
regulate the coolant to the needle probe using the valve;
provide power to the heater based on power demand from the heater;
monitor the power provided to the heater; and
perform a correlation of the monitored power with at least one of a tissue characteristic and/or an operating parameter;
wherein the heater is further configured to actuate the valve to provide more or less of the coolant to the needle probe based on at least one of the correlated tissue characteristic and/or the operating parameter.

US Pat. No. 10,213,243

OSTEOTOME EXTRACTOR

Tornier, Inc., Bloomingt...

1. A method for extracting an implant from a bone, the method comprising:interfacing a tool with an implant having a flange, the flange having a proximal surface and a distal surface, the distal surface bearing on the bone, the flange having at least one aperture formed through the flange;
inserting at least one cutting element through the at least one aperture from the proximal surface to the distal surface and into the bone, wherein the at least one cutting element extends distally from a distal head of the tool along a direction that is substantially parallel to a longitudinal axis of the tool;
rotating the at least one cutting element about the longitudinal axis to cut the bone with a leading edge of the at least one cutting element while simultaneously advancing a notch on the leading edge until a portion of the flange adjacent to the at least one aperture is between proximal and distal ends of the notch.

US Pat. No. 10,213,242

FASTENING DEVICE AND TOOL FOR SURGICAL HOLDING SYSTEMS

CREAHOLIC S.A., Biel (CH...

1. A fastening device for surgical holding systems, comprising a holding element and a fastening element that are mechanically connectable to one another, and a clamping element,wherein the holding element comprises a joint socket, and the fastening element comprises a joint head, wherein the joint socket and the joint head are shaped in a manner corresponding to one another and form a ball joint, and movement of the ball joint is lockable by way of the clamping element,
wherein the clamping element is an eccentric ring that, on rotation, clamps the joint head with respect to the joint socket,
wherein the joint socket defines a joint inner surface of the ball joint, and the joint head defines a joint outer surface of the ball joint, the joint outer surface being part of a sphere,
wherein the ball joint is formed by contact between the joint inner surface and the joint outer surface,
wherein the eccentric ring is rotatably arranged on the holding element and on rotation of the eccentric ring with respect to the holding element, the eccentric ring is pressed against the joint outer surface of the ball joint to lock the movement of the ball joint.

US Pat. No. 10,213,241

METHOD AND DEVICE FOR INSERTION OF ORTHOPEDIC FIXATION PIN WITH BLIND HOLE

Wright Medical Technology...

1. A method, comprising:inserting a k-wire into a bone such that a portion of the k-wire extends from a surface of the bone;
sliding a blind hole of a fixation device over a portion of the k-wire that extends from a surface of the bone;
driving the fixation device into the bone along an axis defined by the k-wire, a bottom wall of the blind hole contacting an end of the k-wire as the fixation device is driven into the bone; and
removing the k-wire from the blind hole.

US Pat. No. 10,213,240

DEPLOYABLE ANCHOR FOR BONE FIXATION

CABLE FIX LLC, Hernando,...

1. A deployable anchor for bone fixation, comprising:a head, positionable within or entirely through an interior portion of a bone and, while positioned within or entirely through the interior portion of the bone, deployable to frictionally engage the bone and fixate the head relative to the bone;
a cable, coupled to the head, wherein the cable is configured to be tensioned to a measurable and adjustable tension; and
a washer fixedly coupled with the head.

US Pat. No. 10,213,239

POROUS PLATE FOR MEDICAL USE AND MANUFACTURING METHOD OF POROUS PLATE FOR MEDICAL USE

FUKUSHIMA MEDICAL UNIVERS...

1. A porous plate for medical use made of a thin-plate substrate comprising a pore perforation section having a plurality of pores perforated therein and a frame section surrounding the pore perforation section, whereinthe thin-plate substrate is a biocompatible metal material,
the pore perforation section has crosspieces which extend lengthwise and crosswise in continuity with the frame section and partition the pore perforation section into a plurality of parts, and a plurality of pore perforation cells each surrounded by the crosspieces, and
the pores perforated in the pore perforation cells have a pore diameter of 1 to 50 ?m, and a center-to-center distance between adjacent pores is 2 to 200 ?m.

US Pat. No. 10,213,238

METHOD AND DEVICE FOR CORRECTING BONE DEFORMITIES

FastForward Surgical Inc....

1. A method of correcting an angular bone deformity in a foot between an unstable bone of the foot and an adjacent stable bone of the foot, comprising:drilling a first opening and a second opening through the unstable bone;
passing a suture through the first opening and positioning the suture such that the suture extends between the adjacent stable bone and the unstable bone;
placing the suture, under tension to reduce the angular deformity between the unstable bone and the adjacent stable bone;
wherein the suture is secured to the unstable bone within the first opening and the second opening that are spaced apart; and
wherein the suture is secured within the first opening and the second opening with a pair of interference screws.

US Pat. No. 10,213,237

PERIPROSTHETIC EXTENSION PLATE

Stryker European Holdings...

25. A method of performing osteosynthesis of a bone part or fragment, comprising:receiving a first fastener into a first portion of an extension plate defining a longitudinal axis, wherein the first portion of the extension plate extends into a hole defined by an inner wall of an elongate plate to attach the extension plate to the elongate plate such that the first fastener does not contact the elongate plate and such that the first portion of the extension plate lies between the first fastener and the inner wall; and
receiving a second fastener into a second portion of the extension plate and into a bone part or fragment, the second portion of the extension plate defining a longitudinal axis, wherein the longitudinal axes defined by the first and second portions of the extension plate are nonparallel when the extension plate is detached from the elongate plate, and wherein the first portion of the extension plate is rotatable such that the second portion is movable relative to the elongate plate.

US Pat. No. 10,213,236

ORTHOPEDIC COMPRESSION PLATE AND METHOD OF SURGERY

Orthohelix Surgical Desig...

1. A system, comprising:a plate having a top surface opposing a bone facing surface in a z-direction and extending along a longitudinal axis from a first end to a second end, wherein the plate includes at least one slot extending from the top surface to the bone facing surface and having opposed faces and a slot mid-plane is defined such that it is positioned an equal distance from each of the opposed faces, and a top plane is defined tangent to the top surface and orthogonal to the slot mid-plane, wherein the plate includes a screw housing extending from the bone facing surface of the plate and a first screw hole extending from the top surface of the plate through the screw housing, wherein the first screw hole extends along a first axis that intersects both the slot mid-plane and the top plane at an oblique angle, wherein the top surface of the plate defines an opening in communication with the first screw hole, and wherein the second end of the plate is chamfered for insertion of the second end into a bone; and
a screw including a head configured to be at least partially received within the opening in the top surface of the plate, wherein the head has a complimentary profile with respect to the opening such that screw can be positioned at a variable angle relative to the longitudinal axis of the plate.

US Pat. No. 10,213,235

SPINOUS PROCESS FUSION DEVICES AND METHODS THEREOF

Globus Medical, Inc., Au...

1. An implantable device comprising:a rod, the rod having a first portion and second portion and having ratchet receivers;
a first wing coupled to the rod on the first portion;
a second wing having an opening and having ratcheting members and being engageable to the rod through the opening;
a central barrel having a first side and a second side, the central barrel capable of being received at least partly around the rod,
wherein the central barrel is configured to distract adjacent spinous processes,
wherein a locking mechanism secures the second wing to the rod, and
wherein the central barrel is configured to be positioned in an interspinous space,
wherein the ratchet receivers of the rod when in a first position engage the one or more ratcheting members and when in a second position the ratchet receivers disengage from the one or more ratcheting members, and
wherein the rod is rotated to move from the first position to the second position.

US Pat. No. 10,213,234

INTERSPINOUS PROCESS FIXATION DEVICES, SYSTEMS, INSTRUMENTS AND METHODS OF ASSEMBLY AND USE

IN QUEUE INNOVATIONS, LLC...

1. A spinous process fixation device, comprising:a first attachment portion comprising:
a first member; and
a second member configured to couple to the first member;
a second attachment portion engaging the first attachment portion, the second attachment portion comprising:
a third member; and
a fourth member configured to couple to the third member;
wherein the first attachment portion and the second attachment portion are positioned to couple to at least two spinous processes;
wherein the first member comprises:
a body;
an engagement member;
a plurality of teeth positioned on the engagement member; and
a slot positioned on an exterior surface of the body and extending from a first side to a second side of the body,
wherein the second member includes comprises:
a body; and
an engagement portion, and the engagement member of the first member couples to the engagement portion of the second member; and
wherein the third member comprises:
a body;
an engagement member; and
a protrusion extending away from an interior surface of the body and extending from a first side to a second side,
wherein the protrusion of the third member engages the slot of the first member when the first attachment portion couples to the second attachment portion,
wherein the fourth member comprises:
a body; and
an engagement portion, and
wherein the engagement member of the third member couples to the engagement portion of the fourth member.

US Pat. No. 10,213,233

DYNAMIC AND NON-DYNAMIC INTERSPINOUS FUSION IMPLANT AND BONE GROWTH STIMULATION SYSTEM

AURORA SPINE, INC., Carl...

1. An interspinous fusion device comprising:a first member having a ring with two or more anchor assemblies projecting laterally from substantially opposite sides of said first member ring, the first member further comprising two columns of teeth formed integrally with the first member;
a second member having a ring with two or more anchor assemblies projecting laterally from substantially opposite sides of said second member ring, the second member further comprising one or more hollow barrels and at least two columns of recesses, said two columns of recesses adapted to mate with the two columns of teeth of the first member, said one or more barrels having opposing window passageways in between the two columns of recesses, such that when the first member is mated with the second member there are no other mechanical components within the one or more barrels such that an unobstructed passage is formed through the window passageways through which bone graft material can extend, and wherein the first member and the second member lock together when the teeth and recesses are mated, said locking occurring without the aid of a set screw, pin or other mechanical component.

US Pat. No. 10,213,232

SYSTEMS, ASSEMBLIES AND METHODS FOR SPINAL DEROTATION

SpineCraft, LLC, Westmon...

13. An assembly useful in a system for correcting alignment of one or more vertebrae of a spine, said assembly comprising:a derotator member comprising:
a first elongate element having a first proximal end portion and a first distal end portion, said first distal end portion being longitudinally split into at least two split portions configured to releasably engage with an implant implanted in one of the vertebrae;
a second elongate element slidable over said first elongate element, said second elongate element having a second proximal end portion and a second distal end portion; and
said first proximal end portion comprising a keyed outer surface having a non-circular cross-sectional shape;
wherein said second distal end portion is slidable over at least part of said split portions thereby preventing said split portions from deforming away from one another; and
wherein said second distal end portion is slidable away from said split portions to an extent to allow said split portions to deform away from one another; and
a linking member for linking the derotator member to a transverse member, said linking member comprising:
a third distal end portion and a third proximal end portion;
said third distal end portion comprising an opening having a keyed inner surface configured to mate with said keyed outer surface of said first proximal end portion, said keyed inners surface being multifaceted and permitting selection from more than two different angular orientations of said linking member relative to a transverse axis of said derotator member, wherein said linking member is maintained in a selected angular orientation once engaged with said derotator member at the selected angular orientation.

US Pat. No. 10,213,231

SYSTEM AND METHOD FOR REDUCING AND STABILIZING A BONE FRACTURE

Life Spine, Inc., Huntle...

1. A spinal implant system comprising:an elongated implant defining a distal portion and a proximal portion, the distal portion including a set of threads, the proximal portion comprising:
a first curved outer surface;
a second curved outer surface opposite the first curved outer surface;
a first planar outer surface extending between the first curved outer surface and the second curved outer surface;
a second planar outer surface opposite the first planar outer surface and extending between the first curved outer surface and the second curved outer surface;
a plurality of ribs defining a plurality of indents, the ribs and indents extending continuously about the periphery of the proximal portion; and
a compression device coupled to the proximal portion of the elongated implant, the compression device movable from an end of the proximal portion towards the distal portion of the elongated implant, wherein the compression device is structured to apply a compression force to a proximal part of the bone fracture, wherein the compression device comprises:
an inner surface;
an upper surface;
a compression surface adapted to engage bone;
a cavity extending from the upper surface toward the compression surface and at least partially defined by the inner surface;
a plurality of projections defining a passage therebetween, each projection extending from the compression surface and the inner surface toward the upper surface and having a top surface located within the cavity and spaced apart from the upper surface;
wherein the proximal portion of the elongated implant extends through the passage and into the cavity on the compression device so that the top surfaces on the plurality of projections engage with a rib of the plurality of ribs, and wherein the inner surface of the compression device is spaced apart from the plurality of ribs of the proximal portion.

US Pat. No. 10,213,230

RECOVERY AND PROCESSING OF HUMAN EMBRYOS FORMED IN VIVO

Previvo Genetics, LLC, S...

1. A kit for removing blastocysts from a woman's uterus and causing corpus luteum apoptosis, consisting of:a uterine lavage catheter configured for insertion into the woman's uterus to remove one or more blastocysts from the uterus;
one or more first containers for storing one or more of biopsied trophectoderm cells or an inner cell mass recovered from the one or more blastocysts following a biopsy procedure to remove the one or more of the biopsied trophectoderm cells or the inner cell mass from the one or more blastocysts;
one or more second containers for storing and cryopreserving the one or more blastocysts following the biopsy procedure, wherein the one or more first and second containers each comprise one or more labels for identifying the one or more of the biopsied trophectoderm cells or the inner cell mass and the one or more blastocyst from which said one or more of the biopsied trophectoderm cells or said inner cell mass was removed; and
one or more third containers with a sufficient dosage amount of a composition suitable to cause corpus luteum apoptosis leading to desynchronization of the endometrium of the uterus.

US Pat. No. 10,213,229

LEAD INSERTION DEVICES AND ASSOCIATED SYSTEMS AND METHODS

Nevro Corp., Redwood Cit...

1. A method for percutaneously implanting medical devices in a patient, the method comprising:inserting or instructing insertion of a cannula into a patient, wherein the cannula includes a lumen;
inserting or instructing insertion of a preceding dilator into the patient via the lumen of the cannula;
removing or instructing removal of the cannula;
inserting or instructing insertion of a subsequent dilator into the patient via advancement of the subsequent dilator over the preceding dilator;
removing or instructing removal of the preceding dilator;
inserting or instructing insertion of a first medical device and a second medical device side by side into a final dilator; and
advancing or instructing advancement of the first medical device and the second medical device into the patient.

US Pat. No. 10,213,228

CANNULA AND METHODS OF USE

1. A surgical instrument, comprising:a cannula including a proximal first end, an opposite distal second end, a body portion extending between the proximal first end and the distal second end, a first flange portion provided adjacent the proximal first end, and a second flange portion provided between the first flange portion and the distal second end, and a cavity extending through the body portion between the proximal first end and the distal second end;
a collar including a first engagement portion and a second engagement portion attached to one another, the first engagement portion being coupled to the body portion between the first flange portion and the second flange portion, and the second engagement portion including an extension portion and a first locking element provided on the extension portion; and
a patient attachable ring including a platform portion, a first passageway extending through the platform portion, and a second locking element formed on the platform portion, the first passageway having a central axis and being configured to receive portions of the cannula therethrough, and the first locking element being configured to engage the second locking element to control the position of the cannula relative to the patient attachable ring, the second locking element including a first wall portion having a first interior surface and a second exterior surface, a second wall portion having a second interior surface and a second exterior surface, a plurality of first slots formed in the first wall portion and spaced apart from one another, and a plurality of second slots formed in the second wall portion and spaced apart from one another, the first wall portion being closer to the central axis than the second wall portion, and respective ones of the first slots and the second slots being aligned with one another, a first portion of the extension portion adjacent the first locking element being receivable either within one of the first slots or within one of the respective ones of the first and second slots, the first locking element being in a first position contacting the first interior surface of the first wall portion when the first portion of the extension portion is received in one of the first slots, and the first locking element being in a second position contacting the second exterior surface of the second wall portion when the first portion of the extension portion is received in one of the respective ones of the first and second slots, wherein movement between the first position and the second position of the first locking element changes the radial position of the cannula relative to the central axis.

US Pat. No. 10,213,227

TRANSCATHETER DEVICE FOR THE ABLATION OF CALCIFIED TISSUE AT THE FLAPS OF AN AORTIC VALVE

1. A transcatheter device for ablation of calcified tissue at leaflets of an aortic valve comprising:a catheter having a soft body and having a soft and flexible endpiece configured to engage with a guide wire and suitable for passing through the leaflets where the calcified tissue needs to be removed;
a cutting system attached to the endpiece and including two motorized rotary cutting heads arranged coaxially one above the other; and
a vacuum suction device arranged in combination with the cutting system, wherein
one of the motorized rotary cutting heads is located at an end of the endpiece and is configured to remove the calcified tissue and to perform a rough cut by grinding, and
the other one of the motorized rotary cutting heads is configured to perform a fine cut by grinding,
the endpiece having an adjustable guide for engaging with the calcified tissue during the ablation performed by the cutting system and for applying a spiral path effect to the endpiece.

US Pat. No. 10,213,226

TISSUE-REMOVING CATHETER INCLUDING URGING MECHANISM

Covidien LP, Alpine, MA ...

1. A tissue-removing catheter for removing tissue from a wall of a body lumen during a cutting operation thereof, the tissue-removing catheter comprising:an elongate catheter body configured for insertion into the body lumen, the catheter body having opposite distal and proximal portions, and a longitudinal axis extending between the distal and proximal portions, the catheter body having a jogged portion configured to apply an urge force against the body lumen wall and urge a portion of the catheter body toward a portion of the body lumen wall;
a tissue-removing element for removing tissue from the body lumen during the cutting operation, the tissue-removing element being located generally adjacent the portion of the catheter body that is urged toward the body lumen wall by the jogged portion;
an urging mechanism configured to selectively apply a compressive load to the catheter body to adjust the bending stiffness of the jogged portion and the urge force applied by the jogged portion,
wherein the catheter body is configured to retain the shape of the jogged portion when the urging mechanism is applying a compressive load to the catheter body.

US Pat. No. 10,213,225

ROBOTIC DEBRIDEMENT APPARATUSES, AND RELATED SYSTEMS AND METHODS

ELWHA LLC, Bellevue, WA ...

1. A robotic debridement apparatus, comprising:a housing including a bottom;
at least one locomotive mechanism positioned in or on the housing, the at least one locomotive mechanism configured to generate a self-propelling locomotive force; and
at least one debriding tool associated with the housing, the at least one debriding tool positioned on the housing to debride tissue of a wound region on an exterior of an individual that is adjacent to or below the bottom of the housing.

US Pat. No. 10,213,224

CLEANING DEVICE FOR CATHETER AND CATHETER INCLUDING THE SAME

1. A cleaning device for cleaning a catheter comprising a catheter body having a distal end portion defining a catheter lumen and proximal and distal openings in fluid communication with the catheter lumen, the cleaning device comprising:a flushing chamber having opposite proximal and distal ends, a flushing lumen extending between the proximal and distal ends, and an inlet port in fluid communication with the flushing lumen, wherein the flushing lumen is configured to accept the distal end portion of the catheter body therein through the proximal end thereof;
a proximal duckbill seal sealingly received in the flushing lumen at a location proximal of the inlet port, the proximal duckbill seal including a pair of opposing duckbill members configured to slidingly accept therebetween the distal end portion of the catheter body to form a proximal fluid seal about the catheter body at a location proximal of the inlet port; and
a distal duckbill seal sealingly received in the flushing lumen at a location distal of the inlet port such that the inlet port is located between the proximal duckbill seal and the distal duckbill seal, the distal duckbill seal being configured to form a distal fluid seal about the catheter body, the distal duckbill seal including a pair of opposing duckbill members configured to slidingly accept therebetween the distal end portion of the catheter body to form the distal fluid seal about the catheter body;
wherein each of the proximal fluid seal and the distal fluid seal is configured to prevent fluid in the flushing lumen from passing therethrough,
wherein the pair of opposing duckbill members defines a tapered distal end of the proximal duckbill seal,
wherein the pair of opposing duckbill members of the distal duckbill seal defines a tapered proximal end of the distal duckbill seal.

US Pat. No. 10,213,223

ARTHROSCOPIC SURGERY METHOD FOR ANKLE LIGAMENT RECONSTRUCTION

OLYMPUS CORPORATION, Tok...

1. An arthroscopic surgery method for ankle ligament reconstruction comprising:a probe that defines a longitudinal axis and transmits ultrasonic vibration; and
a treating portion provided on a distal portion of the probe, the treating portion including a distal surface that intersects with the longitudinal axis, a first projection that projects from the distal surface along the longitudinal axis, and a plurality of second projections that project from the distal surface along the longitudinal axis and have a shorter projecting length than the first projection,
the method comprising:
forming a guide hole in each of a fibula, a talus, and a calcaneus;
inserting the first projection into the formed guide hole;
moving the first projection along the guide hole so that a bone hole that is larger than the guide hole is formed in each of the fibula, the talus, and the calcaneus by the second projections that outputs the ultrasonic vibration; and
fixing a tendon to the formed bone hole.

US Pat. No. 10,213,222

METHODS FOR THREAD TRANSECTION OF A SOFT TISSUE

1. A method for transecting a soft tissue within a body, comprising the steps of:providing a flexible thread-like cutting element having a smooth and non-abrasive surface;
providing a first and a second hollow introducer needle, each having a lumen extending therethrough, one of said needles having an internal diameter sufficient to receive said cutting element and having an external diameter capable to be inserted into the lumen of the other needle;
extending the first hollow introducer needle into the body at a first location transversely adjacent said soft tissue and keeping the first introducer needle inside of the body on a first side of the soft tissue and near a second location transversely adjacent to the soft tissue and opposite the first location;
extending the second introducer needle into the body at the second location and engaging the second introducer needle with the first introducer needle inside the body by inserting the introducer needle into the lumen of the other introducer needle;
extending the cutting element through the lumens of the first and second hollow introducer needles to leave a first end portion of the cutting element projecting proximally and a second end portion projecting distally from the first and second locations respectively;
retracting the first introducer needle from the body so as to leave the cutting element in place;
retracting the second introducer needle from the body so as to leave the cutting element in place;
routing the cutting element transversely adjacent to the soft tissue so as to traverse the soft tissue on a second side thereof opposite the first side;
looping the cutting element about the soft tissue with the first and the second end portions of the cutting element extending out of the body at either the first location or second location; and
exerting force on the first and the second end portions of the cutting element so as to achieve a kerf-less transection of the soft tissue.

US Pat. No. 10,213,221

SURGICAL INSTRUMENTS INCLUDING CAM SURFACES

COVIDIEN LP, Mansfield, ...

1. A surgical instrument, comprising:a housing;
a handle pivotably connected to the housing;
an elongated shaft extending distally from the housing and defining a longitudinal axis;
an end effector assembly disposed adjacent a distal end of the elongated shaft, the end effector assembly including a first jaw member and a second jaw member, at least one of the jaw members being movable with respect to the other jaw member from a spaced-apart position to a position closer to one another for grasping tissue;
a drive assembly disposed at least partially within the housing, the drive assembly including a drive bar extending at least partially through the elongated shaft such that longitudinal translation of the drive bar causes the jaw members to move between the spaced-apart position and the closer position for grasping tissue; and
an extension connected to and extending from the handle, wherein the extension includes a proximal surface having a first proximal cam portion defining a first angle with respect to the longitudinal axis and a second proximal cam portion defining a second angle with respect to the longitudinal axis, each of the first proximal cam portion and the second proximal cam portion configured to contact a first portion of the drive assembly such that movement of the handle with respect to the housing causes longitudinal translation of the drive bar, wherein a distal surface of the first portion of the drive assembly is rounded, wherein initial actuation of the handle from a non-actuated position causes the first proximal cam portion to contact the first portion of the drive assembly causing a first movement of the at least one jaw member, and wherein subsequent actuation of the handle causes the second proximal cam portion to contact the first portion of the drive assembly causing a second movement of the at least one jaw member.

US Pat. No. 10,213,220

SYSTEM AND METHOD FOR PERFORMING AN ARTHROPLASTY PROCEDURE ON A PATIENT BONE

Howmedica Osteonics Corpo...

1. A method of performing an arthroplasty procedure on a patient bone using a jig assembly, the bone having an axis associated with the bone, the axis identified in an analysis of the bone prior to using the jig assembly on the bone, the method comprising:mating a mating surface of a first component of a jig assembly to a surface feature in the patient bone, the mating surface of the first component being a surface negative of the surface feature in the patient bone;
guiding an elongate member into the patient bone via a guide hole operably coupled to the mating surface of the first component;
coupling the first component to a second component of the jig assembly; and
guiding a planar resection of the patient bone via a resection guide surface of the second component, the planar resection being in a pre-planned orientation relative to the axis.

US Pat. No. 10,213,219

TARGETING GUIDE ASSEMBLY

ARTHREX, INC., Naples, F...

1. A targeting guide assembly, comprising:a first bracket;
a second bracket rotatable relative to said first bracket;
a cannula guide body movable along a curvilinear path within a slot formed in said first bracket, wherein the slot extends between a first arm and a second arm of the first bracket, the slot including a track formed in the first arm, and the track is configured to guide movement of the cannula guide body along the curvilinear path;
a cannula received within a bore of said cannula guide body; and
a cannula sleeve received within said cannula.

US Pat. No. 10,213,218

SLEEVE PIN ASSEMBLY FOR FIXING BONE PIECES

SOLCO BIOMEDICAL CO., LTD...

1. A sleeve pin assembly for fixing a plurality of bone pieces, the sleeve pin assembly comprising:a pin having a fixing portion;
a collet portion detachably coupled to the pin;
a fastening portion having one end connected to the collet portion and the other end that can be fastened to an electric drill; and
a sleeve comprising an internal receiving space to receive the collet portion
wherein the fixing portion of the pin has a through-hole that penetrates a cable, and wherein a plurality of the pins inserted into the plurality of bone pieces are connected to the cable inserted into the through holes.

US Pat. No. 10,213,217

ADJUSTABLE DRILL DEPTH GUIDE

EBI, LLC, Parsippany, NJ...

1. A method of adjusting a length of a drill depth guide, the method comprising:providing an adjustable drill depth guide comprising:
a first sleeve having a helical slot;
a second sleeve at least partially disposed within the first sleeve, the second sleeve having a proximal end;
a radially extending stop member coupled to the second sleeve and operably disposed within the helical slot;
a surface-contacting sleeve rotatably coupled to the first sleeve and axially locked with the first sleeve, the surface-contacting sleeve having a distal end; and
a biasing member biasing the second sleeve in a first axial direction of the surface-contacting sleeve, wherein the biasing member biases the second sleeve in the first axial direction toward the distal end of the surface-contacting sleeve;
moving the radially extending stop member in a second axial direction opposite the first axial direction; and
rotating the second sleeve relative to the first sleeve to move the radially extending stop member in a least one of the first axial direction and the second axial direction to change a distance between the proximal end and the distal end.

US Pat. No. 10,213,216

METHOD AND APPARATUS FOR PROVIDING ARTHROSCOPIC MICROFRACTURE THERAPY

Pivot Medical, Inc., Sun...

1. A method for providing therapy to anatomy of a patient and attaching soft tissue to a bone of the patient, wherein the anatomy comprises an acetabulum, wherein the acetabulum comprises an acetabular shelf on a first side of the acetabulum and the acetabular cup on a second side of the acetabulum, wherein the acetabular cup comprises a cortical bone bed, wherein cancellous bone extends between the acetabular shelf and the cortical bone bed, the method comprising:forming a first bone hole, wherein the first bone hole is formed by entering at the acetabular shelf on the first side of the acetabulum, passing through the cancellous bone and exiting at the cortical bone bed on the second side of the acetabulum, such that blood may flow from the cancellous bone to a surface of the cortical bone bed on the second side of the acetabulum, whereby blood may clot at the surface of the cortical bone bed on the second side of the acetabulum;
forming a second bone hole, wherein the second bone hole is formed by entering at the acetabular shelf on the first side of the acetabulum, passing through the cancellous bone and exiting at the cortical bone bed on the second side of the acetabulum, such that blood may flow from the cancellous bone to the surface of the cortical bone bed on the second side of the acetabulum, whereby blood may clot at the surface of the cortical bone bed on the second side of the acetabulum; and
attaching soft tissue to the cortical bone bed on the second side of the acetabulum, wherein the soft tissue is attached to the cortical bone bed on the second side of the acetabulum by (i) passing a suture into the first bone hole from the acetabular shelf on the first side of the acetabulum and out at the cortical bone bed on the second side of the acetabulum, (ii) passing the suture through the soft tissue on the second side of the acetabulum, and (iii) withdrawing the suture from the cortical bone bed on the second side of the acetabulum, through the second bone hole and out at the acetabular shelf on the first side of the acetabulum so that a first leg of the suture extends into the first bone hole from the acetabular shelf on the first side of the acetabulum and out of the cortical bone bed on the second side of the acetabulum, an intermediate portion of the suture extends through the soft tissue positioned at the cortical bone bed on the second side of the acetabulum, and a second leg of the suture extends into the second bone hole from the cortical bone bed on the second side of the acetabulum and out of the acetabular shelf on the first side of the acetabulum.

US Pat. No. 10,213,215

SYSTEMS AND METHODS FOR PREPARING BONE VOIDS TO RECEIVE A PROSTHESIS

Howmedica Osteonics Corp....

1. A method of performing a revision arthroplasty of a proximal tibia comprising:Removing a previously implanted prosthesis through the proximal tibia;
reaming an intramedullary canal of through the proximal tibia with an intramedullary reamer to form a central bone void, the intramedullary reamer having a stem extending from a cutting portion of the intramedullary reamer and through the central bone void in the proximal tibia;
inserting a trial member of a reamer assembly into the tibia and over the stem of the intramedullary reamer such that the stem of the intramedullary reamer extends through the trial member, the reamer assembly having a support member extending from the trial member while the trial member is positioned within the proximal tibia and over the stem of the intramedullary reamer and an offset reamer rotatably and slidably mounted to the support member such that the offset reamer extends along a longitudinal axis in a direction toward the trial member;
reaming into the proximal tibia with the offset reamer to form an offset bone void that intersects the central void; and
implanting a void filling prosthesis into the central and offset voids, the void filling prosthesis having a body and a lobe portion, the body corresponding with the central bone void and having an opening extending therethrough, the lobe portion extending from the body and corresponding with the offset bone void.

US Pat. No. 10,213,214

METHOD TO STOP BLEEDING, WITH SHORT HEMOSTASIS DURATION USING A LOW DOSE OF ANTICOAGULANT

VASOINNOVATIONS, INC., S...

1. A method of reducing a dosage of an anticoagulant when performing a catheterization procedure at an access site of a radial artery, comprising:(a) administering the anticoagulant at a dose less than a conventional dose of an equivalent of 50 units of unfractionated heparin per kg of body weight;
(b) reducing a contact time of blood at the access site of the radial artery by increasing a velocity of blood in the radial artery, said velocity of blood being increased by increasing a flow of blood in the radial artery, wherein the flow of blood in the radial artery is increased by applying an ulnar pressure on an ipsilateral ulnar artery at an ulnar pressure site by inflating at least a first bladder to compress the ulnar artery fully;
(c) maintaining the contact time of blood at a reduced level for a period of time during the catheterization procedure;
(d) applying a radial pressure on the radial artery by inflating at least a second bladder at the access site to stop bleeding at the access site;
(e) continuing to apply the radial pressure on the radial artery for a duration of time at least until hemostasis of the radial artery is attained;
(f) continuing to apply the ulnar pressure on the ulnar artery at the ulnar pressure site to compress the ulnar artery fully for a first period of time, wherein the first period of time is either about 15 minutes or about 30 minutes; and
(g) attaining hemostasis of the radial artery.