US Pat. No. 10,188,181

FASTENER STRINGER AND SLIDE FASTENER PROVIDED WITH SAME

YKK Corporation, (JP)

1. A fastener stringer comprising a row of elements and a fastener tape, at least one side edge of the fastener tape having insulation properties, the row of the elements being attached to the one side edge of the fastener tape, wherein each element comprises a pair of leg portions for holding the fastener tape from front and back sides; and a head portion connecting each leg portion while straddling the one side edge of the fastener tape, the head portion having an engaging region for engaging with an opposing element when constructing a fastener chain; and wherein cured coating film is formed in 50% or more of a total number of the elements at least at a center portion in a front and back direction of the fastener tape on an end surface of the head portion.

US Pat. No. 10,188,180

SLIDER FOR SLIDE FASTENER

YKK Corporation, (JP)

1. A slide fastener slider, configured to move in a front-rear direction, and comprising a slider body having an upper blade and a lower blade connected by a guide post at front end sides thereof, and a pull tab attached to a pull tab attachment portion formed on the upper blade,wherein the pull tab attachment portion has a pair of right and left first members protruding from the upper surface of the upper blade, and a second member connecting the pair of the right and left first members, so as to form an insertion passage opening in the front-rear direction,
wherein the first members have a base portion and a wall portion arranged to extend from the base portion toward at least one of front and rear sides thereof, wherein the pull tab has a string-shaped member and the string-shaped member is inserted into the insertion passage in the front-rear direction and attached to the pull tab attachment portion, and
wherein the wall portions are arranged to extend toward the front sides beyond a front end of the second member or arranged to extend toward the rear sides beyond a rear end of the second member.

US Pat. No. 10,188,178

BUCKLE FOR SEATBELT DEVICE

AUTOLIV DEVELOPMENT AB, ...

1. A buckle for a seatbelt apparatus comprising:a buckle stay that has a fixation portion provided at a base end of the buckle stay and adapted to be fixed to a vehicle body, and a coupling plate portion provided at a leading end of the buckle stay and having a first through-hole;
a buckle base having a bottom plate portion and a pair of side plate portions standing up from opposite side edges of the bottom plate portion, the buckle base also having a second through-hole formed at one end of the bottom plate portion, the side plate portions extending in a longitudinal direction along the bottom plate to overlie a longitudinal position of the second through hole;
a support shaft inserted through the first and the second through-holes, the support shaft being loosely inserted through the first through-hole in the coupling plate portion, to allow the buckle base to be coupled to the buckle stay so as to be able to tilt with respect to the buckle stay through a predetermined angle in a first direction perpendicular to a plate surface of the bottom plate portion and further so as to be able to pivot with respect to the buckle stay, through a predetermined angle in a second direction parallel to the plate surface of the bottom plate portion;
an elastic member that when the buckle base tilts in the first direction and pivots in the second direction, urges the buckle stay to return the buckle base from a deflected position to an original position,
the support shaft integrally forming a generally cylindrical shaft main body and a pair of arm portions provided at an upper portion of the support shaft and extending from a longitudinal axis of the main body in opposing lateral directions, a lower end of the support shaft main body is collapsed against a lower surface of the bottom plate portion of the buckle base to fix the support shaft to the buckle base, the arm portions trapping the buckle stay between the arm portions and the buckle base, and
tip portions of the pair of arm portions are coupled into respective engagement grooves formed in the pair of side plate portions of the buckle base, the engagement grooves cooperating with the pair of arm portions to fix a rotational position of the support shaft relative to the buckle base, the support shaft fixed to the buckle base adjacent to the second through-hole to fixedly mount the support shaft to the buckle base bottom plate portion.

US Pat. No. 10,188,166

HELMET MOUNTED LIGHTING SYSTEM

1. A helmet mounted lighting system comprising:a housing comprising a mounting plate and a cover, the housing is configured to encase an electronic circuit, the electronic circuit comprises a power source, a switch, a capacitor, a logic board, and at least one light emitting diode;
wherein:
a bottom side of the mounting plate is contoured for attachment to a curved exterior surface of a helmet;
a top side of the mounting plate includes a receptacle thereon configured to receive the power source therein, the receptacle comprises a sidewall extending upwardly from the top side of the mounting plate, a top side of the sidewall includes a ledge thereon, the ledge is configured to support at least a portion of a printed circuit board on which the switch, the capacitor, the at least one light emitting diode, and the logic board are located;
the switch is configured to selectively energize the at least one light emitting diode;
the logic board, in conjunction with the switch, is configured to control the operation of the at least one light emitting diode; and
the capacitor is configured to regulate the light output of the at least one light emitting diode.

US Pat. No. 10,188,165

HEADGEAR CONFIGURED FOR POSITIONING OF SPECTACLES

1. Headgear configured for positioning of spectacles comprising:a first extending portion configured to extend under a chin;
a second extending portion configured for extending about a forward portion of a head;
a third extending portion configured for extending about a reward portion of the head;
a first opening in the second extending portion or third extending portion;
a second opening in the second extending portion or third extending portion;
a third opening in the second extending portion or third extending portion and spaced apart from the first opening;
a fourth opening in the second extending portion or third extending portion and spaced apart from the second opening;
the first opening and the third opening being configured and disposed to receive a first eyeglass temple on a first side of the head; and
the second opening and the fourth opening being configured and disposed to receive a second eyeglass temple on a second side of the head.

US Pat. No. 10,188,162

GARDENING UTILITY TOOL

1. An improved gardening utility tool comprising:a glove having a set of glove fingers and a glove thumb;
a set of finger extensions attached to a trank of the glove configured to have an open arrangement wherein the finger extensions are configured to move independently of each other;
a first portion included in each finger extension having a first resiliency;
a second portion included in each finger extension attached to the first portion having a second resiliency wherein a proof resilience of the second portion is higher relative to the first portion;
a set of pivots connecting each first portion to a corresponding second portion allowing the second portions to rotated about a long axis of the first portions;
a plurality of releasable connections disposed on adjacent side surfaces of the finger extensions wherein each of said finger extensions releasably interlocks with an adjacent said finger extension along said adjacent side surfaces to form a composite tool in which all of said finger extensions are locked together to move and operate together in a fixed arrangement;
a forward edge included in each finger extension having a shape taken from the group consisting of: flat, curved, concave, angled, concave angled, pointed, and any combination thereof; and,
a thumb extension attached to the trank.

US Pat. No. 10,188,161

GLOVES WITH SENSORY WINDOWS

1. A glove comprising:(a) an outer surface;
(b) an inner surface;
(c) finger portions; and
(d) an outwardly extending ridge on the inner surface of at least one of the finger portions, wherein the outwardly-extending ridge is between the DIP joint portion and the PIP joint portion, and the outwardly-extending ridge is configured to reduce slippage of the glove when on the hand.

US Pat. No. 10,188,158

WETSUITS WITH HYDRODYNAMIC INTERLOCKING AND KINESIOLOGIC FEATURES

Nike, Inc., Beaverton, O...

1. A wetsuit for aquatic activities, the wetsuit comprising:a base layer having a first surface and an opposite second surface;
a first backing layer having a first surface and an opposite second surface, the second surface of the first backing layer continuously secured to the first surface of the base layer, the first surface of the first backing layer forming an exterior surface of the wetsuit;
a second backing layer secured to the second surface of the base layer and forming at least a portion of an interior surface of the wetsuit; and
at least one sipe linearly extending from the first surface of the first backing layer comprising the exterior surface of the wetsuit through the first backing layer and into the base layer, the at least one sipe extending from an upper portion of a chest region of the wetsuit to a lateral portion of the chest region of the wetsuit.

US Pat. No. 10,188,157

INSULATED ATHLETIC SUPPORT GARMENT

1. An athletic garment, comprising:a waist band;
an insulated panel to conformally cover a groin and genital area of a person, at least one end of the insulated panel being coupled to a portion of the waistband;
a cord contained within a channel surrounding all but a top side of the insulated panel; and
a pair of slidably adjustable connectors on either side of the cord for tightening the insulated panel conformally against the groin and genital area of the person,
wherein the insulated panel is configured to insulate and protect the groin and genital area of the person against an ice bath when the person is submersed therein.

US Pat. No. 10,188,154

BRASSIERE UNDERWIRE REPAIR DEVICE

1. A system for repairing a brassiere having a fabric casing encompassing an underwire whose end tip section has poked a hole through the fabric casing, said system comprising:a hollow, elliptic, cylindrically shaped repair sleeve having an open bottom end and an enclosed rounded top end, and an outer layer of thermal adhesive; and
an installation apparatus, separate and independent from the repair sleeve, whereby the repair sleeve is configured to fit over the end tip section of the underwire and the installation apparatus is configured to be installed into the hole between the repair sleeve and an inner surface of the fabric casing to facilitate the installation of the repair sleeve entirely within the fabric casing.

US Pat. No. 10,188,151

INFANT SWADDLING

1. Infant swaddling comprising:a sheet made of a resilient, moisture-wicking material that maintains pressure on an infant and reduces excess moisture within the sheet when in use, the sheet configured to open to lay flat and defined by an outward-facing surface that, when the infant is placed on the sheet, faces away from the infant and an inner-facing surface that, when the infant is placed on the sheet, faces toward the infant, and the sheet comprising
an upper portion adjacent to an upper edge that, when in use, the infant's head extends beyond the upper portion at the upper edge;
a lower portion adjacent to a lower edge, the lower portion spaced apart from the upper portion;
a first laterally extending region adjacent to a first side edge, the outward-facing surface of the first laterally extending region comprising a first attachment having a first length;
a second laterally extending region adjacent to a second side edge, the inner-facing surface of the second laterally extending region comprising a second attachment that is recloseable with and complementary with the first attachment and having a second length, the first length being longer than the second length, wherein the first attachment and the second attachment are configured to allow adjustment to accommodate the infant's growth; and
wherein the lower portion comprises a loop, spaced apart from the lower edge, wherein the loop is fixed closer to the second side edge than the first side edge, wherein to close access through the lower portion, the lower portion is configured to be gathered and passed through the loop, wherein the loop is configured to reduce the possibility of the lower portion creeping during use, and wherein, when first attachment is closed with the second attachment, the lower portion is configured to be opened, allowing access to the infant near the infant's feet or bottom.

US Pat. No. 10,188,150

INFANT SWADDLING

1. Infant swaddling comprising:a pouch configured to hold and contact an infant when in use, wherein the pouch is made of a resilient, moisture-wicking material that comprises spandex fiber sufficient to maintain pressure on the infant and that reduces excess moisture within the pouch when in use,
the pouch further configured to open to lay flat when not in use to form a sheet, the sheet comprising an outward-facing surface that, when an infant is placed on the sheet, faces away from the infant and an inner-facing surface that, when an infant is placed on the sheet, faces toward the infant, a lateral axis extending from a first side edge to a second side edge of the sheet, and a vertical axis, perpendicular to the lateral axis, extending from an upper edge to a lower edge of the sheet, and the sheet comprising
an upper portion adjacent to the upper edge, wherein, in use, the infant's head extends beyond the upper edge, the upper portion comprising
a first side portion adjacent to the first side edge, the inner facing outward-facing surface of the first side portion comprising a first attachment having a first lateral length,
a second side portion adjacent to the second side edge, the second side portion opposite the first side portion, the inner-facing surface of the second side portion comprising a second attachment having a second lateral length, the second attachment is recloseable with and complementary with the first attachment, the first lateral length at least two times longer than the second lateral length to allow the pouch size to be adjusted to accommodate the infant's growth; and
a lower portion, adjacent to the lower edge,
wherein the lower portion comprises an elastic loop, spaced apart from the lower edge, wherein the elastic loop is fixed closer to the second side edge than the first side edge, wherein to close access to the pouch through the lower portion, the lower portion is configured to be gathered and passed through the elastic loop, wherein the elastic loop is configured to reduce the possibility of the lower portion creeping during use, and wherein, when first attachment is closed with the second attachment, the lower portion is configured to be opened, allowing access to the infant near the infant's feet or bottom.

US Pat. No. 10,188,149

PLACKET TRUSS AND GARMENT INCORPORATING THE SAME

1. A placket truss for use on a placket having a plurality of buttons sewn thereto with thread, said placket truss comprising:an elongate member including opposed end portions;
a medial clip integral with the elongate member and disposed between said opposed end portions, said medial clip including a bend whereby the medial clip doubles back onto the elongate member and extends in a direction transverse to a length of the elongate member; and
wherein each said end portion includes at least one slot sized and adapted to engage the thread of a corresponding button.

US Pat. No. 10,188,147

ATOMIZATION ASSEMBLY AND ELECTRONIC CIGARETTE

HUIZHOU KIMREE TECHNOLOGY...

1. An atomization assembly configured for forming an electronic cigarette with a battery assembly (4), comprising a suction nozzle assembly (1), an atomization core (2) and an e-liquid cup assembly (3), the atomization core (2) and the suction nozzle assembly (1) are respectively arranged at two ends of the e-liquid cup assembly (3); wherein the e-liquid cup assembly (3) comprises an e-liquid storage sleeve (31) and a vent pipe (32), the vent pipe (32) is arranged in the e-liquid storage sleeve (31) for discharging smoke obtained by an atomization of the atomization core (2) to the suction nozzle assembly (1), an e-liquid storage cavity (33) is formed between the e-liquid storage sleeve (31) and the vent pipe (32), one end of the e-liquid storage sleeve (31) is provided with an open end communicating with the e-liquid storage cavity (33), the atomization core (2) is detachably connected to the e-liquid cup assembly (3) and at least one end of the atomization core (2) is inserted into the e-liquid storage cavity (33) from the open end;wherein the atomization core (2) comprises an atomization sleeve (21) and a heating wire assembly (22), the atomization sleeve (21) is provided with an atomization cavity (211) for receiving the heating wire assembly (22) to atomize e-liquid, and a first e-liquid guide hole (212) allowing the e-liquid in the e-liquid storage cavity (33) to flow into the atomization cavity (211) is defined on a side wall of the atomization sleeve (21); and
wherein the atomization core (2) further comprises an e-liquid inlet control structure (23), the e-liquid inlet control structure (23) is sleeved in the atomization sleeve (21) rotatably or movably in an axial direction of the atomization sleeve (21), openings (233) for mounting the heating wire assembly (22) are arranged on the e-liquid inlet control structure (23), and when the e-liquid inlet control structure (23) is rotated or axially moved, the openings (233) and the first e-liquid guide hole (212) are communicated or completely staggered, so as to open or close the first e-liquid guide hole (212).

US Pat. No. 10,188,140

SMOKING ARTICLE

R.J. Reynolds Tobacco Com...

1. A cigarette comprising:a lighting end and a mouth end;
a mouth end piece segment disposed at the mouth end;
an aerosol-generation system including (i) a heat generation segment disposed at the lighting end, said heat generation segment having a length and including a heat source, and (ii) an aerosol-generating segment incorporating aerosol-forming material, said aerosol-generating segment having a length and being disposed adjacent to, and physically separate from, the heat generation segment, said aerosol-generating segment including a substrate for the aerosol-forming material, the substrate abutting with the heat source in the heat generation segment;
a single piece of a first wrapping material providing an overwrap around at least a portion of the length of the heat generation segment and around at least a portion of the length of the aerosol-generating segment;
a segment incorporating tobacco positioned between the aerosol-generating segment and the mouth end piece segment, such that the first wrapping material does not overwrap the segment incorporating tobacco;
a single piece of a second wrapping material providing an overwrap (i) around the segment incorporating tobacco for the length of that segment, (ii) around the aerosol-generating segment for the length of that segment, and (iii) around the heat generation segment for the majority of the length of that segment; the segment incorporating tobacco, the aerosol-generating segment and the heat generation segment being connected together by the second wrapping material to provide a cigarette rod; and
the mouth end piece segment being connected to the cigarette rod using tipping material.

US Pat. No. 10,188,134

AUTHENTICATED ENCRYPTION SUPPORT IN DASH BASED SEGMENTED STREAMING MEDIA DISTRIBUTION

FUTUREWEI TECHNOLOGIES, I...

3. The server apparatus of claim 1, wherein the MPD comprises a @SegmentEncryption@ivEncryptionFlag attribute and a SegmentEncryption@ivLength attribute, wherein the initialization vector is the segment number when the SegmentEncryption@ivEncryptionFlag value is ‘false’ and the MPD comprises a CryptoPeriod element, wherein the initialization vector is a sum of the segment number and an @ivBase attribute when the SegmentEncryption@ivEncryptionFlag value is ‘false’ and the MPD comprises a CryptoTimeline element, wherein the initialization vector is an Electronic Codebook (ECB)-encrypted value of a transmitted initialization vector when the SegmentEncryption@ivEncryptionFlag value is ‘true’ and the MPD does not comprise a CryptoTimeline element or a CryptoPeriod element, wherein the initialization vector is an ECB-encrypted value of the segment number when the SegmentEncryption@ivEncryptionFlag value is ‘true’ and the MPD comprises a CryptoPeriod element, wherein the initialization vector is an ECB-encrypted value of the sum of the segment number and the @ivBase when the SegmentEncryption@ivEncryptionFlag value is ‘true’ and the MPD comprises a CryptoTimeline element, and wherein the initialization vector is the first SegmentEncryption@ivLength most significant bit from ECB output when the SegmentEncryption@ivEncryptionFlag value is ‘true’ and the SegmentEncryption@ivLength is smaller than the output block size of the ECB output.

US Pat. No. 10,188,127

METHOD FOR PRODUCING FROZEN ICE CREAM PRODUCTS

1. A method for producing frozen ice cream products, using a freezing system comprising a freezing apparatus, said method comprising:placing pre-products to be frozen onto a number of product plates,
conveying pre-products to be frozen into the freezing apparatus,
cooling the pre-products to form frozen products while conveying the pre-products inside the freezing apparatus by exposing them to circulating cold air,
conveying the frozen products out of the freezing apparatus,
measuring one or more surface temperatures of frozen products leaving the freezing apparatus,
using the one or more measured surface temperatures as input for a control device for controlling one or more operational parameters of the freezing apparatus,
lifting the frozen products off the product plates, after conveying them out of the freezing apparatus, by means of a product handling system driven by a driving arrangement, and
measuring one or more torque values exerted by the driving arrangement during the lifting of the frozen products off the product plates, and inputting the one or more measured torque values into a control device for controlling one or more operational parameters of the freezing system.

US Pat. No. 10,188,122

CURD CUTTING METHOD

1. A method of cutting a cheese curd mass within a cylindrical vat, the method comprising:placing a cutting apparatus inside the vat before the cheese curd mass has begun to form;
once the cheese curd mass has formed, horizontally rotating a first knife assembly of the cutting apparatus around a vertical axis, thereby cutting the cheese curd mass into a plurality of horizontal slices; and
thereafter, vertically removing from the vat a second knife assembly of the cutting apparatus, the second knife assembly having knives along at least two distinct orientations of the cutting apparatus, thereby cutting the horizontal slices along said orientations.

US Pat. No. 10,188,121

BACTERIOPHAGE TREATMENT FOR REDUCING AND PREVENTING BACTERIAL CONTAMINATION

Ecolab USA Inc., St. Pau...

1. A method of treating and preventing bacterial contamination in a meat food product, the method comprising:applying a bacteriophage treatment to a packaging material as a foam, the bacteriophage treatment comprising:
at least one bacteriophage in a concentration sufficient to reduce or eliminate bacteria selected from the group consisting of pathogenic bacteria, spoilage bacteria, and combinations thereof;
a buffering agent to maintain the bacteriophage treatment at a pH between approximately 4 and 9;
from about 25 ppm to about 2.0 weight percent of a foaming surfactant selected from the group consisting of alcohol ethoxylates, alcohol ethoxylate carboxylate, amine oxides, alkyl sulfates, alkyl ether sulfate, sulfonates, quaternary ammonium compounds, alkyl sarcosines, betaines, alkyl amides and mixtures thereof; and
an adjuvant comprising one or more of calcium, magnesium, a competitive exclusion bacteria, a fatty acid, a terpene, a terpenoid, glycerol, and propylene glycol, and
packaging the food product in the packaging material.

US Pat. No. 10,188,109

PICOLINAMIDE COMPOUNDS WITH FUNGICIDAL ACTIVITY

Dow AgroSciences LLC, In...

1. A compound of Formula I
wherein
X is hydrogen or C(O)R5;
Y is hydrogen, C(O)R5, or Q;
Q is

R1 and R11 are independently chosen from hydrogen or alkyl, optionally substituted with 0, 1 or multiple R8;
alternatively, R1 and R11 may be taken together to form a 3-6 membered saturated or partially saturated carbocyclic or heterocyclic ring, optionally substituted with 0, 1 or multiple R8;
R2 and R12 are independently chosen from hydrogen, alkyl, aryl, or alkenyl, each optionally substituted with 0, 1 or multiple R8;
R3 is methyl;
R4 is chosen from alkyl, aryl, or acyl, each optionally substituted with 0, 1 or multiple R8;
R5 is chosen from alkoxy or benzyloxy, each optionally substituted with 0, 1, or multiple R8;
R6 is chosen from hydrogen, alkoxy, or halo, each optionally substituted with 0, 1, or multiple R8;
R7 is chosen from hydrogen, —C(O)R9, or —CH2OC(O)R9;
R8 is chosen from hydrogen, alkyl, aryl, acyl, halo, alkenyl, or alkoxy, each optionally substituted with 0, 1, or multiple R10;
R9 is chosen from alkyl, alkoxy, or aryl, each optionally substituted with 0, 1, or multiple R8; and
R10 is chosen from hydrogen, alkyl, aryl, acyl, halo, alkenyl, alkoxy, or heterocyclyl.

US Pat. No. 10,188,105

COMPOSITIONS FOR INHIBITION OF INSECT SENSING

Vanderbilt University, N...

1. A compound, or salt thereof, having a formula:
wherein
R1 is hydrogen, optionally substituted C1-C4 alkyl, optionally substituted phenyl, optionally substituted benzyl, or a structure represented by a formula selected from:

or R1 is taken together with R2 to be optionally substituted (C1-C4) alkanediyl or optionally substituted (C1-C4) alkenediyl; and
R2 is hydrogen,
or R2 is taken together with R1 to be optionally substituted (C1-C4) alkanediyl or optionally substituted (C1-C4) alkenediyl; and
R3 is optionally substituted (C1-C5) alkyl or optionally substituted (C1-C5) alkenyl; and
R4 is optionally substituted and selected from (C1-C5) alkyl and (C1-C5) alkenyl; and
R5 is optionally substituted aryl or optionally substituted (?C6) heteroaryl; and
R6 is hydrogen, optionally substituted (C1-C5) alkyl, or optionally substituted (C1-C5) alkenyl,
wherein the compound is not

US Pat. No. 10,188,104

COMBINATIONS OF LIPO-CHITOOLIGOSACCHARIDES AND METHODS FOR USE IN ENHANCING PLANT GROWTH

1. A method of enhancing plant growth, comprising treating a plant seed with at least two distinct lipo-chitooligosaccharides (LCOs) to synergistically enhance growth of a plant that germinates from said seed, said at least two distinct LCOs comprising:

US Pat. No. 10,188,100

MATRIX COMPOSITION FOR DELIVERY OF HYDROPHOBIC ACTIVES

1. A matrix composition capable of forming an emulsion, a microemulsion, or a dispersion comprising an emulsifiable matrix, consisting of:(i) a dialkyl acid amide having the formula:

wherein,
R1 and R2 are lower alkyl with 1-4 carbon atoms, alicyclic or aromatic;
n1=0-18, n2=0-18, and R?H or CH3; and
(ii) one or more surface active agents, wherein the only surface active agents present are selected from the group consisting of ethoxylated castor oil, ethoxylated/propoxylated block copolymer, ethoxylated phosphate ester, sodium dioctyl sulfosuccinate, and poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol), and wherein at least one of the surface active agents is ethoxylated castor oil.

US Pat. No. 10,188,097

MEDICAL DEVICE INTENDED FOR THE LONG-TERM STORAGE OF A CORNEA, OR FOR EX VIVO EXPERIMENTATION ON A HUMAN OR ANIMAL CORNEA

UNIVERSITE JEAN MONNET, ...

1. A device for storage of a corneal specimen including a cornea and a sclera ciliary zone, comprising:an intermediate component including a first hole having a diameter matching that of the cornea, the first hole surrounded by a circumferential groove and a first edge, the first hole, groove, and first edge forming a cavity to receive the corneal specimen, the cavity configured to ensure that the corneal specimen is centered when inserted into the device and configured to stabilize the corneal specimen when the device is opened at an operating theater;
an endothelial lid including a second hole having a diameter matching that of the cornea, the second hole surrounded by a second edge configured to trap the corneal specimen by flattening the sclera ciliary zone on the circumferential groove of the intermediate component; and
an epithelial lid;
wherein the intermediate component and the endothelial lid are configured to entrap the sclera ciliary zone in an airtight manner to delimit an endothelial chamber and an epithelial chamber separate from the endothelial chamber;
wherein the endothelial chamber is composed of a space formed between the endothelial lid and the intermediate component after a tight connection of the endothelial lid to the intermediate component;
wherein the epithelial chamber is composed of a space formed between the intermediate component and the epithelial lid after a tight connection of the epithelial lid to the intermediate component;
wherein the intermediate component and the endothelial lid each comprise a respective inlet orifice and a respective outlet orifice, the orifices allowing a preservation medium to circulate through the endothelial chamber and through the epithelial chamber;
the inlet orifice of the endothelial lid being connected to a preservation medium reservoir containing the preservation medium, such that during use the preservation medium contained in the preservation medium reservoir flows into the endothelial chamber from the preservation medium reservoir;
the outlet orifice of the endothelial lid being connected to the inlet orifice of the intermediate component, such that during use the preservation medium contained in the endothelial chamber flows into the epithelial chamber from the endothelial chamber,
the outlet orifice of the intermediate component being connected to a waste reservoir, such that during use the preservation medium contained in the epithelial chamber flows into the waste reservoir from the epithelial chamber,
the connections of the orifices allowing the preservation medium to circulate on both sides of the cornea, firstly in the endothelial chamber and secondly in the epithelial chamber, and allowing the creation of a pressure gradient between the endothelial chamber and the epithelial chamber with overpressure in the endothelial chamber.

US Pat. No. 10,188,096

DEVICE FOR GRIPPING AND REMOVING A BAIT STATION

1. A gripping device for removing a bait station from a ground soil, the bait station having an opening with a dimension, the opening leading to an internal surface with at least two opposing portals on the internal surface, the gripping device comprising:a) a frame comprising a back end piece and a front end piece spaced from each other by connecting sides, wherein the connecting sides define a bottom portion with a handgrip to conform to fingers of a user;
b) a plunger slidably mounted in an opening in the front end piece;
c) a spring connected between the back end piece and plunger for biasing the plunger toward a second extended gripping position from a first retracted position;
d) a first hook fixedly attached to the frame; and
e) a second hook attached to the plunger for movement between the first retracted position and the second extended gripping position,
wherein the first hook and the second hook fit within the dimension of the opening of the bait station when the plunger is in the first retracted position and wherein the first hook and the second hook engage the two opposing portals when the plunger is in the second extended gripping position; and
wherein the plunger has a thumb piece opposite the engagement of the spring with the plunger and wherein the front end piece includes a thumb cover that has a bottom, two sides, and an open top to allow a user's thumb to engage the thumb piece.

US Pat. No. 10,188,095

TREE STAND

1. A tree stand comprising a seating member having:first and second side members, the side members extending substantially parallel with each other with a bend in each of the first and second side members, the first and second side members each having a first end and a second end opposite the first end;
a removable tree attachment member, the removable tree attachment member being a linear member running substantially orthogonal to the first and second side members, spanning from the first side member to the second side member proximate to the first end of the first and second side members;
a fixed tree attachment member, the fixed tree attachment member running substantially orthogonal to the first and second side members, spanning from the first side member to the second side member at a location between the bend and the first end of each of the first and second side members;
first and second angled tree attachment members, the first and second angled tree attachment members interconnecting the fixed tree attachment member with each of the first and second side members, the first and second angled tree attachment members forming an angle with the fixed tree attachment member from about 30 degrees to about 60 degrees;
a fixed seat defining member, the fixed seat defining member running substantially orthogonal to the first and second side members, spanning from the first side member to the second side member proximate to the second end of the first and second side members; and
a seat attached to the side members via a plurality of seat straps, each of the seat straps disposed as loops about the side members, the loops disposed between the fixed tree attachment member and the fixed seat defining member.

US Pat. No. 10,188,093

ACTIVE ELECTROSTATIC WILDLIFE GUARD FOR ELECTRICAL POWER DISTRIBUTION EQUIPMENT

TE Connectivity Corporati...

1. An apparatus for wildlife deterrence on a high voltage conductor, the apparatus comprising:an electrical insulator including an electrically insulating material without a conductive material, the electrical insulator comprising:
a first surface;
a second surface that is opposite the first surface;
a first edge that is between the first surface and the second surface, the first edge and the first and second surfaces defining outer edges of the first and second surfaces, respectively; and
a second edge that is opposite the first edge and that is between the first surface and the second surface, the second edge and the first and second surfaces defining interior edges of the first and second surfaces, respectively;
a third edge that is between a proximal end of the first edge and a proximal end of the second edge and that is between the first surface and the second surface;
a fourth edge that is between a distal end of the first edge and a distal end of the second edge and that is between the first surface and the second surface;
a central opening defined in the electrical insulator including through the first and second surfaces; and
a gap defined by the third edge and the fourth edge that communicates with the central opening;
an electrical conductor that is arranged on the first surface of the electrical insulator and is spaced apart from each of the first edge and the second edge, wherein the electrical conductor extends continuously from the third edge to the fourth edge.

US Pat. No. 10,188,092

BREAKAWAY ADAPTER SYSTEM FACILITATING BOTH FRONT-MOUNTED AND REAR-MOUNTED CONFIGURATIONS OF A SPRAYER BOOM

CNH Industrial America LL...

1. A breakaway adapter system facilitating both front-mounted and rear-mounted configurations of a sprayer boom of an agricultural sprayer, wherein the sprayer boom includes a main boom body connected to the agricultural sprayer with the main boom body having outer ends, a sprayer facing side facing toward the sprayer, and an outwardly facing side facing away from the sprayer, wherein the breakaway adapter system comprises:a pair of breakaway boom segments arranged outwardly beyond outer ends of the main boom body;
a pair of breakaway joints arranged between the outer ends of the main boom body and the pair of breakaway boom segments, wherein the breakaway joints are configured to allow the breakaway boom segments to deflect in rearward deflection directions; and
a pair of adapter arrangements between the outer ends of the main boom body and the pair of breakaway joints, each adapter arrangement configured to engage and support either breakaway joint of the pair of breakaway joints;
wherein when the sprayer boom is in the front-mounted configuration, the breakaway joints mount to the adapter arrangements in a first mounting position in which the breakaway joints are arranged to allow the breakaway boom segments to deflect in a deflection direction that is common with a direction faced by the sprayer facing side of the main boom body; and
wherein when the sprayer boom is in the rear-mounted configuration, the breakaway joints mount to the adapter arrangements in a second mounting position in which the breakaway joints are arranged to allow the breakaway boom segments to deflect in a deflection direction that is common with a direction faced by the outwardly facing side of the main boom body.

US Pat. No. 10,188,090

FISH RECEPTACLE

1. A fish receptacle, comprising:a container having a base, one or more upstanding sidewalls, an open upper end, defining an interior volume, the container configured to store water and fish therein;
a lid pivotally connected to the upper end of the container, the lid providing access to the interior volume of the container;
a door assembly disposed on the lid, the door assembly comprising a frame disposed around a perimeter of an aperture disposed through the lid;
wherein the frame is affixed to an upper surface of the lid about the aperture, wherein a front wall, a rear wall, a left wall, and a right wall each extend perpendicularly away from the frame;
a track disposed within the frame, wherein the track comprises two opposing rails disposed within each of the left and right walls of the frame and a slot through the rear wall of the frame;
wherein the door assembly further comprises a sliding member configured for sliding engagement with the track;
wherein the sliding member is movable between an open position to expose the aperture of the door assembly and a closed position to at least partially cover the aperture.

US Pat. No. 10,188,089

DEVICE FOR REMOVING A FISH FROM A LINE

1. A fish removing device, comprising:a first end bending back into a U shaped end configured to engage a fishing line;
the U shaped end extending into a straight section; and
a gripping section connected to the straight section.

US Pat. No. 10,188,079

STRAP FOR ATTACHING A DECORATIVE ORNAMENT TO THE HEAD OF A PET

1. A strap assembly for securing a decorative ornament to a head of an animal, comprising:a chin strap comprising a continuous loop;
a first ear strap for placement around a back of a first ear of the animal;
a second ear strap for placement around a back of a second ear of the animal; and
an ornament attachment device permitting an ornament to be removably attached thereto;
wherein the first ear strap and the second ear strap can be joined together permitting the joined-together ear straps to wrap under the neck of the animal;
wherein the first ear strap and the second ear strap are portions of a single, continuous elongated strip when joined together;
wherein the chin strap is attached to the continuous elongated strip;
wherein the ornament attachment device is attached to the chin strap and the continuous elongated strip at the point where the chin strap and the continuous elongated strip are attached together.

US Pat. No. 10,188,050

VOLUMETRIC BUDGET BASED IRRIGATION CONTROL

Rain Bird Corporation, A...

1. A method of controlling irrigation, the method comprising:receiving water usage information corresponding to a first volumetric water usage at a site location having an irrigation controller configured to implement and control irrigation at the site and comprising valve drivers each configured to activate one or more valves distributed through the site location and an irrigation controller processor configured to implement an irrigation schedule stored in local memory of the irrigation controller, wherein the first volumetric water usage corresponds to volumetric water usage from a beginning of a budget period of time to a first time within the budget period of time;
determining automatically whether a volumetric water budget at the site location will be met for the budget period of time based on at least the first volumetric water usage, the volumetric water budget corresponding to a specified volume of water for use during the budget period of time;
determining automatically, in the event the volumetric water budget will not be met, an adjustment to the irrigation by the irrigation controller, wherein the adjustment comprises a reduction of runtimes of remaining irrigation events scheduled to occur during the budget period of time such that the adjustment substantially spreads a compensation for an amount of water usage that will exceed the volumetric water budget over the remaining irrigation events; and
outputting signaling causing the irrigation controller to control the valve drivers of the irrigation controller to control opening and closing of one or more of the valves at the site location coupled with the irrigation controller in controlling water released through water delivery devices fluidly coupled with a corresponding one of the valves in controlling irrigation at the irrigation site to effect the adjustment.

US Pat. No. 10,188,047

PLANT LABELING SYSTEM AND GARDEN TOOLS

1. A modular display system, comprising:a seed storage hutch;
a vertical display stand supporting the seed storage hutch;
at least one pigtail attached to the stand and configured to support at least one growing pot, hook or shelf above the ground, wherein the at least one pigtail is attached to the stand and may be swiveled, positioned vertically along the stand or removed entirely; and
a base configured to receive and support the display stand in a substantially vertical orientation.

US Pat. No. 10,188,044

TREE-TRIMMING DEVICE

1. A horticultural tool comprising:a reciprocating shaft, an extension guard and an extensible structure;
wherein the horticultural tool is configured to use with a reciprocating saw;
wherein the reciprocating saw further comprises a reciprocating structure;
wherein the horticultural tool is a bladed device that is adapted for use in cutting a plant;
wherein the horticultural tool is configured to extend the reach of the reciprocating saw;
wherein the reciprocating shaft is configured to connect the extensible structure to the reciprocating saw;
wherein the extensible structure is inserted through the extension guard;
wherein the reciprocating shaft is attached to the reciprocating structure of the reciprocating saw;
wherein the reciprocating shaft includes a spring-loaded button that is used to secure a linking shaft to the reciprocating saw;
wherein the spring-loaded button is biased outwardly via a spring;
wherein the spring-loaded button of the reciprocating shaft interfaces with a button-hole provided on the linking shaft;
wherein the extension guard comprises a guard, a support, and a foot;
wherein the guard is formed in the shape of a frustum of a pyramid wherein the base of the pyramid is attached to the reciprocating saw;
wherein the support is a square structure that forms a frustum surface that is proximal to the apex of the pyramid;
wherein the foot is a structure that attaches to the support such that the foot projects away from the support in a direction away from the reciprocating saw;
wherein the guard comprises a frame;
wherein the frame is the structural framework that forms the pyramidal shape of the guard;
wherein the frame is formed from a plurality of metal shafts;
wherein the support comprises a plurality of rollers, and a plurality of corners;
wherein the support is a square shaped structure;
wherein each of the plurality of corners is a piece of metal;
wherein each of the plurality of corners is used to form a corner of the square shaped structure;
wherein any first corner selected from the plurality of corners is attached to a second corner selected from the plurality of corners by a roller selected from the plurality of rollers.

US Pat. No. 10,188,032

MOWER WITH MOTOR COOLING

KUBOTA CORPORATION, Osak...

1. A ride-on mower comprising:an operator seat;
drive wheels;
steerable wheels;
at least one rotationally driven grass cutting blade;
at least one motor configured to cause rotation of the grass cutting blade;
said at least one motor comprising a motor housing having an axial length that is shorter than half a cross-sectional diameter or width;
a mower deck compromising a blade rotation space defined by an upper surface and a downward extending sidewall, said mower deck housing the grass cutting blade in an interior thereof;
at least one guide member defining an air flow passage along the motor housing, the air flow passage connecting the interior and exterior of the mower deck; and
said at least one guide member being a separately formed member that is mounted to the mower deck and said at least one guide member having an axial length that is shorter than a diameter or cross-sectional width of said at least one guide member,
wherein the guide member guides a cooling air flow that flows outside of the motor housing, said cooling air flow entering from above the guide member, passing downwards axially between the guide member and the motor housing, and then, inside the mower deck, passing radially inwards towards a motor shaft, and
wherein the cooling flow passing radially inwards towards the motor shaft occurs below the upper surface and inside the blade rotation space.

US Pat. No. 10,188,022

ROTATING LIFT SYSTEM AND METHOD

Bestway, Inc., Hiawatha,...

1. A system for placing a load on a vehicle including a vehicle frame, which load-placing system comprises:a load lift assembly having a first, lowered position for connecting to a load, a second, raised position with said load lifted above a level of said vehicle frame, and a third, transport position with said load positioned over and connected to said vehicle frame;
a lift actuator connected to said load lift assembly and configured for moving said load lift assembly between its lowered and raised positions;
a transfer actuator connected to said load lift assembly and configured for moving said load lift assembly between its raised and transport positions axially along said vehicle frame;
said load lift assembly including a lower linkage assembly including a pair of lift arms configured for connecting to two points of said three-point hitch;
said load lift assembly including a top link configured for connecting to a third point of said three-point hitch;
said top link being pivotally pinned to a pair of mounting brackets affixed to said load lift assembly;
a hydraulic reservoir assembly configured to operate said lift actuator and said transfer actuator;
a motor assembly configured to provide power to said hydraulic reservoir assembly;
a control assembly configured to send control signals to said hydraulic reservoir assembly;
a first hydraulic arm connected to a front end of said vehicle frame, said hydraulic arm configured for moving said load lift assembly between said second, raised position in proximity to a rear end of said vehicle frame and said third, transport position in proximity to said front end of said vehicle frame; and
a second hydraulic arm configured to pivot said lower linkage assembly about said lift arm weldment.
US Pat. No. 10,188,131

HYDROCOLLOIDS COPROCESSED WITH CELLULOSIC FIBERS WHEN BEING SHEARED INTO HIGHLY REFINED CELLULOSE

1. A method for refining cellulosic material from parenchymal fiber mass comprising:soaking raw non-refined material from organic fiber plant mass comprising at least 50% by weight of all fiber mass as the parenchymal fiber mass in an aqueous solution with less than 1% NaOH;
draining the raw non-refined material and allowing the raw material to sit for sufficient time to enable cells in the raw non-refined material to form open cells and expand the raw material into an expanded fiber product, the soaking producing soaked raw materials with open cells;
refining the soaked raw material to produce refined material by shearing the soaked raw materials in the presence of at least 10% by weight of hydrocolloid with respect to the weight of the organic fiber plant mass; and
then drying the sheared mixture of highly refined cellulosic fiber and hydrocolloid.
US Pat. No. 10,190,186

METHOD FOR MANUFACTURING A HIGH-STRENGTH GALVANIZED STEEL SHEET HAVING EXCELLENT FORMABILITY AND CRASHWORTHINESS

JFE Steel Corporation, T...

1. A method for manufacturing a high-strength galvanized steel sheet having excellent formability and crashworthiness, the method comprising:hot-rolling a steel slab having a composition containing, by mass %, C: 0.05% or more and 0.5% or less, Si: 0.01% or more and 2.5% or less, Mn: 0.5% or more and 3.5% or less, P: 0.003% or more and 0.100% or less, S: 0.02% or less, Al: 0.010% or more and 0.5% or less, B: 0.0002% or more and 0.005% or less, Ti: 0.05% or less, a relationship of Ti>4N being satisfied, and the balance comprising Fe and inevitable impurities at a finish rolling temperature of an A3 transformation point or higher;
after the completion of finish rolling, subsequently cooling the resulting steel sheet to a coiling temperature at an average cooling rate of 30° C./s or more;
coiling the steel sheet at the coiling temperature of 300° C. or higher and 550° C. or lower to form a hot-rolled steel sheet;
then performing heat treatment on the hot-rolled steel sheet, the heat treatment including heating the hot-rolled steel sheet to an annealing temperature of (A3 transformation point ?20° C.) or higher and (A3 transformation point +80° C.) or lower at an average heating rate of 5° C./s or more in a temperature range of 500° C. or higher and an A1 transformation point or lower, holding the steel sheet at the annealing temperature for 10 seconds or more, then cooling the steel sheet from 750° C. to a temperature range of 100° C. or higher and 350° C. or lower at an average cooling rate of 30° C./s or more, subsequently reheating the steel sheet to a temperature of 300° C. or higher and 600° C. or lower, and holding the steel sheet at the temperature for 10 seconds or more and 600 seconds or less;
then galvanizing the steel sheet, and optionally performing an alloying treatment, such that the high-strength galvanized steel sheet is formed having a microstructure containing 64% or more and 95% or less of tempered martensite in terms of area ratio and 5% or more and 20% or less of retained austenite in terms of area ratio, the tempered martensite having an average grain diameter of 5 ?m or less.
US Pat. No. 10,189,932

THERMOPLASTIC MOLDING COMPOUNDS WITH AN OPTIMIZED RESIDUAL MONOMER CONTENT

INEOS STYROLUTION GROUP G...

1. A process for the production of styrene graft copolymers comprising the following steps:(i) provision and agglomeration of the graft base B present in an emulsion;
(ii) addition of styrene monomers A1 and vinyl cyanide monomers A2 to the graft base B over a defined monomer feed time; and
(iii) simultaneous graft copolymerization of the added styrene monomers A1 and of the vinyl cyanide monomers A2 onto the agglomerated graft base B,
where, in step (ii), the ratio by mass of styrene monomers A1 to vinyl cyanide monomers A2 in the monomer feed at the end of the monomer feed time is lower than the ratio by mass of the components of the monomer feed integrated over the entire monomer feed time,
where step (iii) is followed by the following step (iv), which comprises:
(iv) addition of vinyl cyanide monomers A2 and graft copolymerization of these onto the agglomerated graft base B, where no styrene monomers A1 are added.
US Pat. No. 10,188,908

POLYAMIDE COMPOSITIONS CONTAINING PLASTICIZERS FOR USE IN MAKING GOLF BALLS

Acushnet Company, Fairha...

1. A golf ball, comprising:a) a core comprising an inner core and outer core layer, the inner core having an outer surface and geometric center and the outer core layer having an outer surface and inner surface; the inner core comprising a polyamide composition and the outer core layer comprising a rubber composition the polyamide composition comprising:
i) about 40 to about 90% by weight polyamide; and
ii) about 10 to about 60% by weight of a plasticizer selected from the group consisting of ethyl oleate and propylene carbonate and blends thereof, the polyamide comprising a blend of transparent and non-transparent polyamides, wherein at least one of the transparent polyamides is a polyether-amide block copolymer, and wherein the center of the inner core and surface of the outer core layer each has a hardness, and the surface hardness of the outer core layer is greater than the center hardness of the inner core; and
b) a cover having at least one layer disposed about the core.
US Pat. No. 10,188,654

USES OF PYRIMIDO-PYRIDAZINONES TO TREAT CANCER

Asana BioSciences, LLC, ...

1. A method of treating a cancer subject, comprising administering to a cancer subject in need thereof, a therapeutically effective amount of a compound 2-(1-(4-((4-(4-hydroxypiperidin-1-yl)phenyl)amino)-5-oxo-5,6-dihydropyrimido[4,5-d]pyridazin-2-yl)piperidin-4-yl)acetonitrile, or a pharmaceutically acceptable salt or ester thereof, wherein:the cancer subject has a recurrent or refractory cancer;
the cancer is a hematopoietic cancer; and
the cancer is refractory to Ibrutinib.
US Pat. No. 10,189,936

BLOCK COPOLYMER, DISPERSANT, AND PIGMENT DISPERSION COMPOSITION

OTSUKA CHEMICAL CO., LTD....

1. A block copolymer of an ABA type including an A block and a B block and having an acid value of 30 to 250 mgKOH/g, the B block containing a structural unit derived from a vinyl monomer with an acid group, wherein a structural unit derived from a vinyl monomer with an acid group and contained in the A block is at a content of 10% by mass or less in 100% by mass of the A block.
US Pat. No. 10,189,937

FINE POWDER-COATED AMINE AND COMPOSITION CONTAINING SAME

SUNSTAR ENGINEERING INC.,...

1. A fine powder-coated amine comprising a solid amine having a melting point equal to or higher than 50° C. and a mean particle size equal to or smaller than 20 ?m, wherein the fine powder-coated amine has an amount of heat in the second absorption peak measured by a differential scanning calorimeter equal to or less than 220 J/g, and the surface of the solid amine is coated with fine particles having a mean particle size equal to or smaller than 2 ?m.
US Pat. No. 10,190,194

COPPER ALLOY FOR ELECTRONIC AND ELECTRICAL EQUIPMENT, COPPER ALLOY THIN SHEET FOR ELECTRONIC AND ELECTRICAL EQUIPMENT, AND CONDUCTIVE COMPONENT FOR ELECTRONIC AND ELECTRICAL EQUIPMENT, TERMINAL

MITSUBISHI MATERIALS CORP...

1. A copper alloy for electronic and electrical equipment, comprising:more than 2.0 mass % to 36.5 mass % of Zn;
0.10 mass % to 0.90 mass % of Sn;
0.15 mass % to less than 1.00 mass % of Ni;
0.005 mass % to 0.100 mass % of P; and
a balance containing Cu and inevitable impurities,
wherein an atomic ratio Ni/P of an amount of Ni to an amount of P satisfies a relationship of 3.00 an atomic ratio Sn/Ni of an amount of Sn to an amount of Ni satisfies a relationship of 0.10 a strength ratio TSTD/TSLD is 1.10 or more, where strength TSTD is obtained when a tensile test is performed in a direction perpendicular to a rolling direction and strength TSLD is obtained when another tensile test is performed in a direction parallel to the rolling direction.
US Pat. No. 10,188,657

COMPOSITIONS AND METHODS FOR PROPHYLAXIS AND THERAPY FOR MENIERE'S DISEASE

1. A method comprising administering to an individual diagnosed with Meniere's Disease a pharmaceutical composition comprising an effective amount of lamotrigine or a pharmaceutically acceptable salt thereof such that the effective amount of the lamotrigine or the pharmaceutically acceptable salt thereof is sufficient to reduce dizziness that is caused by the Meniere's Disease in the individual, and wherein the lamotrigine or the pharmaceutically acceptable salt thereof is the only bioactive compound in the pharmaceutical composition that is effective to treat the dizziness caused by the Meniere's Disease.
US Pat. No. 10,189,941

POLYCARBONATE COMPOSITIONS CONTAINING POLYETHYLENE WAX

Covestro Deutschland AG, ...

1. A polycarbonate composition comprisingA) polycarbonate
B) oxidized acid-modified polyethylene wax and
D) an inorganic filler,
wherein the oxidized acid-modified polyethylene wax has an acid number of <10 mg KOH/g determined according to JIS K0070, a crystallinity of greater than 60% and less than 90%, a melting point between 90° C. and 130° C. and a viscosity average molar mass determined by viscometry between 1500 g/mol and 5000 g/mol.
US Pat. No. 10,188,660

ANTI-HULRRC15 ANTIBODY DRUG CONJUGATES AND METHODS FOR THEIR USE

AbbVie Inc., North Chica...

1. An anti-huLRRC15 antibody drug conjugate (ADC) comprising an antimitotic agent linked to an anti-huLRRC15 antibody by way of a linker, wherein the ADC has a structure of formula (I):[D-L-XY]n-Ab  (I)
or a salt thereof, wherein:
D is the antimitotic agent;
L is the linker;
Ab is the anti-huLRRC15 antibody;
XY represents a covalent linkage linking linker L to antibody Ab; and
n is an integer ranging from 2 to 8;
wherein
Ab comprises
a VH chain comprising the sequence of SEQ ID NO:16 and a VL chain comprising the sequence of SEQ ID NO:17,
a VH chain comprising the sequence of SEQ ID NO:26 and a VL chain comprising the sequence of SEQ ID NO:27,
a VH chain comprising the sequence of SEQ ID NO:36 and a VL chain comprising the sequence of SEQ ID NO:37,
a VH chain comprising the sequence of SEQ ID NO:46 and a VL chain comprising the sequence of SEQ ID NO:47,
a VH chain comprising the sequence of SEQ ID NO:56 and a VL chain comprising the sequence of SEQ ID NO:57,
a VH chain comprising the sequence of SEQ ID NO:66 and a VL chain comprising the sequence of SEQ ID NO:67, or
a VH chain comprising the sequence of SEQ ID NO:76 and a VL chain comprising the sequence of SEQ ID NO:77.
US Pat. No. 10,190,198

THICK FILM PASTE AND USE THEREOF

E I DU PONT DE NEMOURS AN...

1. A thick film paste composition comprising:(a) inorganic constituents that consist of:
a platinum source that is at least one of a particulate platinum (alloy) or a particulate platinum (alloy)/metal oxide composite, and
at least one metal compound selected from the group consisting of particulate metal oxides and precursor compounds capable of forming a metal oxide on firing, the metal oxide in each case being selected from the group consisting of NiO, SiO2, RuO2, Rh2O3, IrO2, Cu2O, CuO, TiO2, ZrO2, PbO, SnO2, CeO2, Al2O3, MgO, and MnO2; and
(b) an organic vehicle,
and wherein:
the proportion of the at least one metal compound is 0.001 to 1 wt. %, based on the total thick film paste composition; and
the thick film paste composition is capable of being fired to form an electrically conductive metallization that is electrically connected with an electrode on a ceramic sensor substrate.
US Pat. No. 10,189,943

COPOLYMERS SUITABLE FOR MAKING MEMBRANES

BASF SE, Ludwigshafen (D...

1. A copolymer, comprising polyarylene ether blocks and hydrophilic-hydrophobic blocks,wherein:
said hydrophilic-hydrophobic blocks comprise polyisobutene blocks; and
said hydrophilic-hydrophobic blocks comprise polyisobutene blocks with terminal phenolic ether groups, and said phenolic ether groups are etherified with polyalkyleneoxides.
US Pat. No. 10,189,945

METHOD FOR PRODUCING LIGHT-COLOURED TDI-POLYISOCYANATES

Covestro Deutschland AG, ...

1. A method for producing polyisocyanates comprising urethane groups and having APHA colour indices <50 Hazen comprising reacting di- to tetra-valent organic polyhydroxy compounds with excess amounts of toluylene diisocyanate and then removing unreacted excess toluylene diisocyanate to residual contents <0.5 wt. % by distillation, wherein the toluylene diisocyanate has a content of 2-chloro-6-isocyanato-methylcyclohexadienes <5 wt·ppm.
US Pat. No. 10,188,667

PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE OF 4-PREGENEN-11?-17-21-TRIOL-3,20-DIONE DERIVATIVES

ALLERGAN, INC., Irvine, ...

1. A method of treating an ocular condition associated with glucocorticoid and or mineralocorticoid receptor modulation which comprises topically administering to a patient in need thereof, a pharmaceutical composition comprising a therapeutically effective amount of at least one compound selected from:(8S,9S,10R,11S,13S,14S,17R)-17-glycoloyl-11-hydroxy-10,13 -dimethyl-3 -oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl phenylacetate;
(8S,9S,10R,11S,13S,14S,17R)-17-glycoloyl-11-hydroxy-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl butyrate;
(8S,9S,10R,11S,13S,14S,17R)-17-glycoloyl-11-hydroxy-10,13 -dimethyl-3 -oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl propionate;
(8S,9S,10R,11S,13S,14S,17R)-17-glycoloyl-11-hydroxy-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl octanoate;
(8S,9S,10R,11S,13S,14S,17R)-17-Glycoloyl-11-hydroxy-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl hexanoate;
(8S,9S,10R,11S,13S,14S,17R)-17-glycoloyl-11-hydroxy-10,13 -dimethyl-3 -oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl benzoate;
(8S,9S,10R,11S,13S,14S,17R)-17-glycoloyl-11-hydroxy-10,13 -dimethyl-3 -oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl heptanoate;
(8S,9S,10R,11S,13S,14S,17R)-17-glycoloyl-11-hydroxy-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl 2-methylpropanoate; and
(8S,9S,10R,11S,13S,14S,17R)-17-glycoloyl-11-hydroxy-10,13 -dimethyl-3 -oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl cyclopentanecarboxylate,
and further comprising carboxymethylcellulose, sodium phosphate, citrate buffer, and sodium chloride,
and having a pH from about 4.5 to 7.5.
US Pat. No. 10,189,952

DEGRADABLE THIOL-ENE POLYMERS

REGENTS OF THE UNIVERSITY...

21. A method for producing a biocompatible thiol-ene hydrogel, the method comprisingsubjecting a polymerization reaction mixture comprising at least one thiol compound and at least one olefin compound to a radical polymerization reaction under conditions sufficient to produce the biocompatible thiol-ene hydrogel, wherein:
(a) the at least one thiol compound comprises m number of reactive thiol groups;
(b) the at least one olefin compound comprises n number of reactive ene groups; and
(c) each of n and m is an integer of at least 2, provided the sum of n+m is at least 5.
US Pat. No. 10,190,219

ELECTRICAL STEEL SHEET

1. An electrical steel sheet, comprising:a base material of electrical steel; and
an insulating film formed on a surface of the base material,
wherein the insulating film contains a phosphate of one or more selected from the group consisting of Al, Zn, Mg and Ca,
wherein a proportion of an amount by mole (mol) of Fe atoms relative to an amount by mole (mol) of P atoms in the insulating film is not less than 0.30 and not more than 0.65, and
a limit sodium chloride concentration is 0.1 mass % or more,
wherein the limit sodium chloride concentration represents a maximum concentration of the sodium chloride solution with which the electrical steel sheet does not rust when 0.5 ?L liquid droplets of sodium chloride solutions different in concentration are deposited on the surface of the electrical steel sheet having the insulating film and dried, and the electrical steel sheet is held in an atmosphere with constant temperature and humidity of a temperature of 50° C. and a relative humidity of 90% for 48 hours.
US Pat. No. 10,190,226

REACTION PRODUCTS OF HETEROCYCLIC NITROGEN COMPOUNDS POLYEPOXIDES AND POLYHALOGENS

Rohm and Haas Electronic ...

1. A compound comprising a reaction product of one or more heterocyclic nitrogen compounds comprising at least two reactive nitrogen atoms with the proviso that at least one of the reactive nitrogen atoms is in the ring of the one or more heterocyclic nitrogen compounds; one or more polyepoxide compounds and one or more polyhalogen compounds, wherein the one or more polyhalogen compounds have a formula:X1—R13—X2  (VII)wherein X1 and X2 may be the same or different and are halogens chosen from chlorine, bromine, fluorine and iodine, R13 is linear or branched, substituted or unsubstituted (C1-C20)alkyl, or is a moiety having formula:—C(HR14)—R15—C(HR14)—  (VIII)wherein each R14 is independently selected from hydrogen, halogens chosen from chlorine, bromine, fluorine and iodine, linear or branched, substituted or unsubstituted (C1-C18)alkyl, substituted or unsubstituted (C6-C12)cycloalkyl, substituted or unsubstituted (C6-C15)aryl; R15 is linear or branched, substituted or unsubstituted (C1-C18)alkyl, substituted or unsubstituted (C6-C12)cycloalkyl, substituted or unsubstituted (C6-C15)aryl, —CH2—O—(R16—O)d—CH2— where R16 is a substituted or unsubstituted, linear or branched (C2-C10)alkyl and d is an integer of 1-10.
US Pat. No. 10,189,716

ZEOLITE MONOLITH AND METHOD OF MAKING THE SAME, COMPOSITE WITH ZEOLITE MONOLITH AND METHOD OF MAKING THE SAME, AND METHOD FOR INCORPORATING TWO OR MORE ZEOLITE MONOLITHS

1. A method of manufacturing a porous monolithic zeolite structure including the steps of:(a) taking a porous monolithic substrate;
(b) forming one or more zeolites on the substrate; and
(c) substantially or completely removing said substrate.
US Pat. No. 10,189,976

CURABLE COMPOSITION COMPRISING AN ETHYLENE POLYMER, A MONOPEROXYCARBONATE AND A T-ALKYL HYDROPEROXIDE

ARKEMA FRANCE, Colombes ...

1. A curable composition comprising:(a) at least one ethylene polymer,
(b) at least one monoperoxycarbonate, and
(c) from 0.05 to less than 0.4 part by weight of at least one t-alkyl hydroperoxide for 100 parts by weight of constituent (b).
US Pat. No. 10,189,979

NUCLEATED PHTHALATE-FREE PP HOMOPOLYMERS FOR MELT-BLOWN FIBERS

BOREALIS AG, Vienna (AT)...

1. A polypropylene composition suitable for the production of meltblown PP fibers comprising:(A) a propylene homopolymer, produced with a Ziegler-Natta catalyst (ZN-C), and
(B) a polymeric nucleating agent,
wherein the polypropylene composition has
i) a melt flow rate MFR2 (230° C./2.16 kg) measured according to ISO 1133 of 90 to 5000 g/10 min, and
ii) a difference between melting temperature (Tm) and crystallization temperature (Tc), (Tm?Tc) of <45° C., and
wherein the propylene homopolymer has been visbroken and has an MFR2 of 400 to 3000 g/10 min.
US Pat. No. 10,188,698

SAPOSIN C-DOPS: A NOVEL ANTI-TUMOR AGENT

1. A method for decreasing tumor volume in a subject comprising the step of administering to the subject a composition comprisinga phospholipid, wherein the phospholipid is phosphatidylserine;
an isolated saposin C-related polypeptide, wherein the polypeptide has an amino acid sequence at least 85 percent identical to SEQ ID NO: 2 and wherein the polypeptide includes amino acids 24-40 of SEQ ID NO:2; and
wherein the phospholipid forms a nanovesicle incorporating the polypeptide.
US Pat. No. 10,188,702

METHODS AND COMPOSITIONS FOR TREATING HYPOGLYCEMIC DISORDERS

THE TRUSTEES OF THE UNIVE...

1. A method of treating congenital hyperinsulinism in a subject having congenital hyperinsulinism comprising administering to the subject an effective amount of a peptide wherein the amino acid sequence of the peptide consists of the amino acid sequence set forth in SEQ ID NO: 1.
US Pat. No. 10,189,217

METHOD FOR PREPARING THERMOPLASTIC PREPREG AND THERMOPLASTIC PREPREG PREPARED THEREBY

KOLON INDUSTRIES, INC., ...

1. A method for preparing a thermoplastic prepreg, comprising:laminating a thermoplastic resin film having a crystallization degree in a range of 1 to 20% on at least one surface of a matrix fiber to give a laminate; and
heating the laminate to a higher temperature than a melting point of the thermoplastic resin film, then, pressing the heated laminate,
wherein the thermoplastic prepreg has a weight variation per unit area of 3-5%,
said weight variation per unit area being determined by the following equation (I) or (II):
weight variation per unit area (%)=[(W0?W1)/W0]×100  (I)
weight variation per unit area (%)=[(W1?W0)/W0]×100  (II)
wherein W0 is an average weight of 10 samples of the thermoplastic prepreg, and
W1 is a weight of the samples which show the greatest difference from the average weight W0.
US Pat. No. 10,188,707

ENOLASE 1 (ENO1) COMPOSITIONS AND USES THEREOF

Berg, LLC, Framingham, M...

1. A pharmaceutical composition comprising enolase 1 (Eno1) or a fragment thereof and a muscle targeting peptide, wherein the Eno1 or a fragment thereof and the muscle targeting peptide are in a complex;wherein the Eno1 or a fragment thereof has glycolytic activity and is present in a therapeutically effective amount; and
wherein the muscle targeting peptide is a smooth muscle targeting peptide, a skeletal muscle targeting peptide, or a smooth muscle and skeletal muscle targeting peptide.
US Pat. No. 10,189,993

SILOXANE COMPOSITION AND METHOD FOR PRODUCING SAME

SHIN-ETSU CHEMICAL CO., L...

1. A method of preparing a siloxane composition, comprising:a step of producing a crosslinked organopolysiloxane having a weight-average molecular weight of 5,000 to 300,000,000 and containing 0.1 to 50 moles of silethylene linkages per 1,000 moles of siloxane units by hydrosilylation of an organopolysiloxane having a structure of formula (1) below with an organohydrogenpolysiloxane having a structure of formula (2) below
M?MVi?D?DVi?T?TVi?Q?  (1)
M?MH?D?DH?T?TH?  (2)(wherein M is R3SiO1/2, MVi is R2PSiO1/2, D is R2SiO2/2, DVi is RPSiO2/2, T is RSiO3/2, TVi is PSiO3/2, MH is R2HSiO1/2, DH is RHSiO2/2, TH is HSiO3/2 and Q is SiO4/2, each R being independently an unsubstituted or substituted monovalent hydrocarbon group of 1 to 12 carbon atoms that has no aliphatic unsaturated bonds and P being an alkenyl group represented by —(CH2)a—CH?CH2 (where “a” is 0 or an integer from 1 to 6); and ?, ?, ?, ?, ?, ?, ?, ?, ?, ?, ?, ? and ? are each independently 0 or a positive number, with the provisos that ?, ? and ? are not all 0, ?+?+??2, ?, ? and ? are not all 0, and ?+?+??2) in an amount of solvent that is at least 8 times the combined weight of the polysiloxanes of formulas (1) and (2) and using a platinum group metal compound, andafter obtaining the crosslinked organopolysiloxane using an organic solvent selected from among toluene, hexane, xylene and methyl ethyl ketone as the solvent: adding a low-viscosity organopolysiloxane as a solvent, and distilling off the organic solvent by heating under reduced pressure so as to give a composition that contains no organic solvent.
US Pat. No. 10,190,002

AQUEOUS MULTI-STAGE EMULSION COPOLYMER COMPOSITIONS FOR USE IN JOINERY APPLICATIONS

Rohm and Haas Company, P...

1. An aqueous composition comprising aqueous multistage emulsion copolymer compositions comprising (a) one or more dihydrazide compounds in a total amount of from 0.5 to 4 wt. %, based on the total weight of composition solids, and (b) of one or more aqueous multistage emulsion copolymers containing, as (i) a first stage, an emulsion copolymer having a glass transition temperature (Tg) via differential scanning calorimetry (DSC) of from ?50 to 30° C., and containing, in copolymerized form, from 0.5 to 3.0 wt. % of one or more monoethylenically unsaturated phosphorous acid monomers and, from 0.75 to 5 wt. % of one or more keto group containing amide monomers, and, as (ii) a second stage, an emulsion copolymer having a DSC Tg of from 50° C. to 125° C., wherein the Tg difference between the first stage and the second stage is from 45° C. to 150° C. having a weight ratio of (i) the first stage to (ii) the second stage, based on copolymer solids, ranging from 50:50 to 90:10 or, all monomer wt. % s based on the total weight of monomers used to make the aqueous multistage emulsion copolymer, and, further wherein, the (ii) second stage of the aqueous multistage emulsion copolymer comprises, in copolymerized form, no more than 25 wt. % of the total monoethylenically unsaturated phosphorous acid monomers used to make the aqueous multistage emulsion copolymer, and no more than 50 wt. % of the total keto group containing amide monomers used to make the aqueous multistage emulsion copolymer, and wherein (b) at least one of the one or more aqueous multistage emulsion copolymer comprises, in copolymerized form, at least 90 wt. % of the one or more monoethylenically unsaturated phosphorous acid monomers in the (i) first stage.
US Pat. No. 10,188,723

FUNCTIONAL INFLUENZA VIRUS LIKE PARTICLES (VLPS)

NOVAVAX, INC., Gaithersb...

1. A vaccine comprising an influenza VLP, wherein said VLP comprises influenza proteins, wherein the influenza proteins consist of M1, HA and NA proteins; wherein the M1 protein is derived from a different influenza virus strain than the HA and NA proteins; wherein the influenza proteins are insect-cell expressed, and wherein the M1 protein is from an avian influenza strain.
US Pat. No. 10,190,261

STRENGTHENING RESINS FOR PAPER PRODUCTS

ECOLAB USA INC., St. Pau...

1. A fiber mixture, comprising:a plurality of fibers; and
a resin composition comprising:
about 10 wt % to about 80 wt % of a polyamide-epihalohydrin resin comprising a reaction product of a polyamidoamine and an epihalohydrin;
about 10 wt % to about 80 wt % of a cationic styrene maleimide resin comprising a reaction product of a styrene maleic anhydride copolymer and an amine compound; and
about 10 wt % to about 80 wt % of a urea-formaldehyde resin, wherein the weight percent values of the polyamide-epihalohydrin resin, the cationic styrene maleimide resin, and the urea-formaldehyde resin are based on a combined solids weight of the polyamide-epihalohydrin resin, the cationic styrene maleimide resin, and the urea-formaldehyde resin.
US Pat. No. 10,188,726

SYNTHETIC HEPATITIS C POLYPEPTIDE AND METHODS OF MAKING AND USING SAME

The Johns Hopkins Univers...

1. The polypeptide encoded by a nucleic acid comprising SEQ ID NO: 1, encoding the genome of the synthetic hepatitis C virus subtype 1a (Bole 1a).
US Pat. No. 10,188,984

PROCESS FOR REMOVING OXIDISABLE GASEOUS COMPOUNDS FROM A GAS MIXTURE BY MEANS OF A PLATINUM-CONTAINING OXIDATION CATALYST

1. A process for catalytic oxidative removal of at least one oxidisable gaseous compound from a gas mixture, the gas mixture comprising the at least one oxidisable gaseous compound as well as oxygen, the process comprising:reacting H2Pt(OH)6 with oxalic acid in an aqueous solution to form platinum oxalate complexes of the formula (H3O)1.6[Pt(C2O4)2]. 2H2O;
forming an oxidation catalyst by adding the platinum oxalate complexes to a porous catalyst support and exothermically decomposing the platinum oxalate complexes to generate catalytically active platinum species; and
oxidizing the gas mixture with the oxidation catalyst, wherein
the gas mixture is not a combustion flue gas.
US Pat. No. 10,188,729

MODULATION OF TUMOR IMMUNITY

1. A method of treating a tumor in a patient comprising administering to the patient a bispecific antibody comprising(i) a first arm having a light chain (LC) variable region that comprises the amino acid sequences of CDR-L1, CDR-L2 and CDR-L3 of an LC variable region having the amino acid sequence of the LC variable region of MK-3475 and a heavy chain (HC) variable region that comprises the amino acid sequences of CDR-H1, CDR-H2 and CDR-H3 of an HC variable region having the amino acid sequence of the HC variable region of MK-3475; and
(ii) a second arm having an LC variable region that comprises the amino acid sequences of CDR-L1, CDR-L2 and CDR-L3 of an LC variable region having the amino acid sequence set forth in SEQ ID NO: 82 wherein residue 31 is Q and residue 57 is Q; and an HC variable region that comprises the amino acid sequences of CDR-H1, CDR-H2 and CDR-H3 of an HC variable region having the amino acid sequence set forth in SEQ ID NO: 81.
US Pat. No. 10,193,094

ORGANIC LIGHT-EMITTING DEVICE HAVING DELAYED FLUORESCENCE

Merck Patent GmbH, (DE)

1. An organic electroluminescent device comprisinganode,
cathode,
at least one emitting layer which comprises a luminescent organic compound E which has a difference between the energies of its S1 and T1 states of not greater than 0.15 eV, and
2, 3, 4 or 5 layers H each having a thickness of greater than 2 nm which are arranged between one emitting layer of said at least one emitting layer, which is closest to said anode, and said anode,
where the following conditions apply to each layer H:
a difference D between the HOMO energy level of a layer H and the HOMO energy level of the closest layer having a thickness of greater than 2 nm on a cathode side of this layer H must be less than or equal to 0.4 eV, and
each of the layers H comprises at least one triarylamino compound which is a small organic molecule,
with the proviso that, for layers whose HOMO energy level has a value of less than ?6.7 eV, the LUMO energy level for the said condition occurs instead of the HOMO energy level and wherein the emitting layer which comprises compound E additionally comprises one or more matrix materials, and in that compound E is an emitting compound and the energy of the T1 state of the matrix material of the emitting layer is at most 0.1 eV lower than the energy of the T1 state of compound E.
US Pat. No. 10,190,020

SILOXANE-BASED COATINGS CONTAINING POLYMERS WITH UREA LINKAGES AND TERMINAL ALKOXYSILANES

The United States of Amer...

8. A composition comprising:an amine-functional compound or an epoxy- or acrylate-functional compound; and
a urea-containing composition made by a method comprising:
reacting an amino-functional alkoxysilane with a first polyisocyanate to form one or more adducts having an unreacted isocyanate group; and
reacting the adducts with one or more polyfunctional amino- and/or hydroxyl compounds and a second polyisocyanate to form the urea-containing composition;
wherein the urea-containing composition comprises at least two residues of the polyfunctional amino- and/or hydroxyl compounds;
wherein isocyanate groups do not react with other isocyanate groups; and
wherein the urea-containing composition contains no unreacted isocyanate groups;
wherein the urea-containing composition is characterized by any of:
a) at least one of the polyfunctional amino- and/or hydroxyl compounds comprises an amino group and at least one of the polyfunctional amino- and/or hydroxyl compounds comprises a hydroxyl group;
b) at least one of the polyfunctional amino- and/or hydroxyl compounds is a polyfunctional amino compound; and
c) the urea-containing composition comprises one of more compounds having the formula:
{[(R1O)aR13-aSi—(CH2)3—NR2—CO—NH]n—R3—NH—CO—X—R5—X—CO—NH}m—R3
wherein each a is independently selected from 1, 2, or 3;
wherein m is 2 or 3;
wherein each n is independently selected from 1 or 2;
wherein each X is independently selected from —NR4— and —O—;
wherein each R1 group is an independently selected alkyl group;
wherein each R2 and R4 is independently selected from hydrogen, aryl, alkyl, cycloalkyl, ester-containing aliphatic, ester-containing fluorinated aliphatic, amide-containing aliphatic, and polysiloxane;
wherein each R3 is an independently selected residue of an aliphatic, cycloaliphatic, or aromatic polyisocyanate having 2 or 3 isocyanate groups; and
wherein each R5 independently comprises a group selected from aliphatic, cycloaliphatic, aromatic, polyester, polyether, polysulfide, polyurethane, polycarbonate, polysiloxane, and any combination thereof moisture-curing the composition.
US Pat. No. 10,193,097

LIGHT-EMITTING ELEMENT, LIGHT-EMITTING DEVICE, AND ELECTRONIC DEVICE

Semiconductor Energy Labo...

10. A light-emitting element comprising:a first electrode;
a hole-injecting layer over the first electrode
a hole-transporting layer over the hole-injecting layer;
a light-emitting layer over the hole-transporting layer;
an electron-transporting layer over the light-emitting layer;
an electron-injecting layer over the electron-transporting layer;
a second electrode over the electron-injecting layer;
a first layer between the hole-transporting layer and the light-emitting layer; and
a second layer between the light-emitting layer and the electron-transporting layer,
wherein:
the light-emitting layer includes a first phosphorescent compound,
the first layer includes a first hole-transporting material and a first electron-transporting material,
the second layer includes a second hole-transporting material and a second electron-transporting material,
the second hole-transporting material includes a second phosphorescent compound,
in the first layer, a concentration of the first hole-transporting material is higher than that of the first electron-transporting material,
in the second layer, a concentration of the second electron-transporting material is higher than that of the second hole-transporting material, and
a difference between a wavelength of a highest peak of an emission spectrum of the second phosphorescent compound and a wavelength of a highest peak of an emission spectrum of the first phosphorescent compound is within 30 nm.
US Pat. No. 10,188,740

MODIFIED FC MOLECULES

AMGEN INC., Thousand Oak...

1. A composition of matter comprising:(i) a monomeric or multimeric Fc domain having a cysteine or non-canonical amino acid substitution at one or more specifically selected conjugation site(s) selected from D46, S48, H49, E50, E53, K55, D61, G62, Q76, Y81, K107, K121, G122, Q123, E126, R136, D137, T140, K141, N142, E169, N170, N171, K173, L179, S181, G183, D194, K195, R197, Q199, Q200, G201, N202, or S223, relative to reference sequence SEQ ID NO:599; and
(ii) at least one additional functional moiety, wherein the functional moiety is conjugated to the Fc domain through the side chain of the cysteine residue or non-canonical amino acid residue substituted at said one or more conjugation site(s).
US Pat. No. 10,189,766

PROCESS FOR PRODUCING 2-ETHYLHEXANAL HELPING TO IMPROVE YIELD

NAN YA PLASTICS CORPORATI...

1. A process for producing 2-ethylhexanal helping to increase yield of 2-ethylhexanal, comprises the following steps:1) placing a reaction liquid containing 60-100 wt % of 2-ethyl-2-hexenal into a single reaction tank having internally equipped with a gas-introducing mixer which comprising a hollow rotatory shaft thereof and vanes at a terminal of the hollow rotatory shaft for use in introducing and exhausting hydrogen gas to the reaction liquid and simultaneously stirring the reaction liquid if started;
2) based on the weight of 2-ethyl-2-hexenal, adding a palladium on carbon catalyst ranged from 0.02 wt % to 15 wt % for hydrogenation, whose palladium component is supported on a carbon carrier having a total content of impurities less than 8% by weight of the carbon carrier, and whose specific surface area of the impurities of the carbon carrier is ranged between 800 m2/g and 3,000 m2/g;
3) introducing hydrogen gas to 80-600 lb/in2 and holding this pressure;
4) activating the gas-introducing mixer to stir the reaction liquid at room temperature and held the pressure for 10 minutes, heating to 70-150° C., and allowing hydrogenation for 1-10 hours at this temperature; and
5) upon completion of the reaction, cooling the reaction liquid to room temperature and filtering out the catalyst to obtain a yield of the 2-ethylhexanal at least up to 98.0%.
US Pat. No. 10,191,303

MULTIFOCAL BIMODULUS CONTACT LENSES

NexisVision, Inc., Menlo...

1. An ophthalmic lens for correcting presbyopia of an eye, the eye having a cornea characterized by a refractive shape extending across an optical region of the cornea, the ophthalmic lens comprising:an inner optic portion and a peripheral portion disposed radially outward of the inner optic portion, wherein,
the inner optic portion is configured to be disposed over the optical region of the cornea;
the inner optic portion is characterized by an inner rigidity and the peripheral portion is characterized by a peripheral rigidity;
the inner rigidity is greater than the peripheral rigidity; and
the inner rigidity is from about 1E8 MPa-?m3 to about 1E11 MPa-?m3; and
an anterior surface and a posterior surface opposite the anterior surface, wherein,
a portion of the anterior surface is configured to correct presbyopia; and
the posterior surface is configured to provide one or more lenticular volumes between the posterior surface and the optical region of the cornea.
US Pat. No. 10,189,767

PROCESS FOR MANUFACTURING SUCCINIC ACID FROM A FERMENTATION BROTH USING NANO FILTRATION TO PURIFY RECYCLED MOTHER LIQUOR

DSM IP ASSETS B.V., Heer...

1. A process for manufacturing succinic acid comprising:a) providing an aqueous solution of succinic acid;
b) crystallizing the succinic acid from the aqueous solution to form intermediate crystals and a mother liquor;
c) separating the intermediate crystals from the mother liquor;
d) treating the mother liquor by nanofiltration;
e) recycling the treated mother liquor to b);
f) purifying the intermediate crystals; and
g) recovering succinic acid.
US Pat. No. 10,191,048

FLUOROMETRIC IMMUNOASSAY FOR DETECTION OF ANTI-DSDNA ANTIBODIES

1. A fluorometric immunoassay method for detecting antibodies against double-stranded DNA (anti-dsDNA), comprisingproviding decomplemented sera from a patient, providing isolated dsDNA as antigens from a source,
Precipitating immune complexes with a saturated solution of ammonium sulfate or solution of polyethylene glycol (PEG), wherein the immune complexes are a consequence of incubation of decomplemented patient's sera with the dsDNA,
separating the immune complexes into two samples,
labeling the samples by adding fluorescent dyes specific to the dsDNA to the samples, and
detecting of fluorescence in the samples, namely sample with supernatant and sample with precipitate, comprising immune complexes comprising dsDNA and anti-dsDNA,
wherein the detected fluorescence is a consequence of binding of fluorescent dyes into the dsDNA.
US Pat. No. 10,188,744

AMPHIPATHIC PEPTIDE

1. An amphipathic cell penetrating peptide of less than 50 amino acid residues comprising at least 6 arginine residues (R), at least 12 alanine residues (A), at least 6 leucine residues (L), optionally at least one cysteine residue (C) and at least two but no greater than three glutamic acids (E) whereinthe arginine (R) residues are evenly distributed along the length of the peptide;
the ratio of arginine (R) to negatively charged glutamic acid (E) residues is from at least 6:2 to 9:2; and
the ratio of hydrophilic amino acid residues to hydrophobic amino acid residues at pH 7 is at least 30:67 to 40:60; or
wherein the peptide comprises or consists of WEARLARALARALARELARALARALRACEA (SEQ ID No. 4).
US Pat. No. 10,190,026

WOOD ADHESIVE

INDUSTRIAL TECHNOLOGY RES...

1. A wood adhesive, consisting of:a first agent, consisting of:
a sodium carboxymethyl cellulose having a molecular weight between 15,000 and 500,000 and a degree of substitution of from 0.4 and 2.00 of the sodium salt; and
a styrene-butadiene rubber polymer; and
a second agent, consisting of:
a polymeric quaternary amine and NaOH, wherein a ratio of the weight of the styrene-butadiene rubber polymer to the sum of weights of the sodium carboxymethyl cellulose and the polymeric quaternary amine is in the range from 0.05:1 to 1:0.1.
US Pat. No. 10,190,027

HOT MELT ADHESIVE

1. A hot melt adhesive comprising:(A) 1-15 wt % of a polar functional group-modified conjugated diene-based polymer;
(B) 10-50 wt % of a butyral resin;
(C) 5-40 wt % of an olefin-based polymer;
(D) 5-70 wt % of a tackifier resin; and
(E) 10-40 wt % of a wax.
US Pat. No. 10,188,747

METHODS AND COMPOSITIONS FOR THE TREATMENT OF CANCER

The General Hospital Corp...

1. A method of treating squamous cell carcinoma in a subject in need of treatment thereof, the method comprising administering to the subject an agonist of a gene selected from the group consisting of:Esr2; Dlx5; and Egr3.
US Pat. No. 10,189,772

MIXTURES OF CHELATING AGENTS INCLUDING AN L-ENANTIOMER-RICH MGDA, AND PROCESS FOR MAKING SUCH MIXTURES

BASF SE, Ludwigshafen (D...

1. A mixture, comprising:(A) 90 to 99.9% by weight of a mixture of L- and D-enantiomers of methyl glycine diacetic acid (MGDA) or its respective mono-, di- or trialkali metal or mono-, di- or triammonium salts, said mixture containing predominantly the respective L-enantiomer with an enantiomeric excess (ee) in the range of from 10 to 99%, and
(B) in total 0.1 to 10% by weight of a diacetic acid derivative of at least one amino acid selected from the group consisting of valine, leucine, isoleucine, and tyrosine, as free acids or respective mono-, di- or trialkali metal or mono-, di- or triammonium salts,
wherein the percentages refer to the sum from (A) and (B).
US Pat. No. 10,190,029

REMOVABLE POLYURETHANE HOT MELT ADHESIVE AND THE USE THEREOF

1. A removable reactive hot melt adhesive comprising a (meth)acrylate polymer and an isocyanate-functional polyurethane prepolymer, wherein the (meth)acrylate polymer has a number average molecular weight from about 25000 g/mol to about 60000 g/mol and is selected from a copolymerization product of butyl acrylate and methyl methacrylate as monomers having a melting point of from about 100° C. to about 120° C., a copolymerization product of butyl methacrylate and methyl methacrylate as monomers having a melting point about 110° C., and combinations thereof; andwherein the cured adhesive has a bond strength of about 5.0 MPa or greater at room temperature and a bond strength of about 0.8 MPa or less at a temperature of about 70° C. to about 90° C.
US Pat. No. 10,188,748

PHARMACEUTICAL COMPOSITION CONTAINING A STABILISED MRNA OPTIMISED FOR TRANSLATION IN ITS CODING REGIONS

1. A cell-free mRNA pharmaceutical composition comprising at least one modified mRNA and a pharmaceutically compatible carrier, wherein the modified mRNA encodes at least one human tumour-specific antigenic polypeptide capable of stimulating an immune response in a patient against the human tumour-specific antigenic polypeptide wherein said modified mRNA encoding the human tumour-specific antigenic polypeptide has been stabilized by increasing its Guanosine/Cytosine (G/C) content by at least 7 percentage points relative to that of the wild type mRNA encoding the tumour-specific antigenic polypeptide.
US Pat. No. 10,188,750

SELF-REPLICATING CELL SELECTIVE GENE DELIVERY COMPOSITIONS, METHODS, AND USES THEREOF

University of South Flori...

1. A polyribonucleotide comprising:a RNA molecule of interest (ROI), wherein the ROI is an RNA capable of being translated into p27;
a microRNA (miRNA) target sequence, wherein the miRNA target sequence is a target for miR-126, and wherein the miRNA target sequence is operatively linked to the ROI; and
a RNA molecule capable of being translated into a viral RNA replicase, wherein the RNA molecule capable of being translated into a viral RNA replicase is operatively linked to the ROI, the miRNA target sequence, or both the ROI and miRNA target sequence.
US Pat. No. 10,191,056

DIAGNOSTIC EVALUATION OF ANTIBODY RESPONSES TO COMMONLY RECOGNIZED PROSTATE CANCER-ASSOCIATED ANTIGENS

Wisconsin Alumni Research...

1. An antigen panel for identifying immunoreactivity associated with a premalignant or malignant prostate, the panel comprising antigens encoded by SEQ ID NO:5, SEQ ID NO:10, SEQ ID NO:12, SEQ ID NO:17, SEQ ID NO:18, SEQ ID NO:19, SEQ ID NO:20, SEQ ID NO:24, SEQ ID NO:25, SEQ ID NO:32, SEQ ID NO:34, SEQ ID NO:35, SEQ ID NO:40, SEQ ID NO:44, SEQ ID NO:64, SEQ ID NO:68, SEQ ID NO:72, SEQ ID NO:76, SEQ ID NO:78, SEQ ID NO:80, SEQ ID NO:86, and SEQ ID NO:91, the encoded antigens being immobilized on one of a membrane, a plate, and a filter, and having a positive likelihood ratio of at least 4.
US Pat. No. 10,189,008

ODOR AND COLOR STABLE WATER-ABSORBING COMPOSITION

Evonik Degussa GmbH, Ess...

1. A water-absorbing composition comprising at least: i) from 91.2 to 98.9 wt % of at least one water-absorbing polymer; ii) from 1 to 8 wt % of at least one oxidizing agent; and iii) from 0.1 to 0.75 wt % of at least one inhibitor to inhibit free-radical polymerizations; wherein the inhibitor is a hydroquinone or a hydroquinone derivative selected from the group consisting of hydroquinone, hydroquinone monomethyl ether (HQME), 1,4-dimethoxybenzene, 4,4?-oxydiphenol and a mixture of two or more thereof; and wherein the weight quantities are each based on the overall weight of the water-absorbing composition.
US Pat. No. 10,188,752

DUAL-MODALITY IMAGING PROBE FOR COMBINED LOCALIZATION AND APOPTOSIS DETECTION OF STEM CELLS

The Board of Trustees of ...

1. A dual-modality imaging probe for simultaneous, one-stop, cell apoptosis detection and stem cell tracking, comprising: ferumoxytol with a fluorescent signature peptide immobilized on the surface of the ferumoxytol, wherein the fluorescent signature peptide is a KKKKDEVD-AFC peptide (SEQ ID NO:1).
US Pat. No. 10,189,778

PROCESS FOR THE PREPARATION OF METHIONINE ALPHA-HYDROXY ANALOGUES FROM SUGARS AND DERIVATIVES THEREOF

1. A process for the preparation of a methionine ?-hydroxy analogue and derivatives thereof of the formula:R?—S—CH2—CH2—CHOH—COO—R  (I)wherein R is selected from the group consisting of H, C1-C8 alkyl, alkaline or alkaline-earth metals; and R? is selected from the group consisting of H and methyl; andwherein the process comprises a step of contacting one or more sugars or derivatives thereof selected from the group consisting of glucose, fructose, galactose, mannose, sucrose, xylose, erythrose, erythrulose, threose, glycolaldehyde, methyl vinyl glycolate,vinyl glycolic acid and 2-hydroxyl-?-butyrolactone with a metallo-silicate zeotype material, in the presence of a compound comprising sulphur and a solvent, wherein the metallo-silicate zeotype material has a framework structure selected from the group consisting of BEA, MFI, FAU, MOR, and FER, with a metal and/or metal oxide component.
US Pat. No. 10,189,779

METHODS FOR PRODUCING THIOL COMPOUNDS AND SULFIDE COMPOUNDS USING DIPHENYLAMINE OR A PHENOL COMPOUND

Chevron Phillips Chemical...

1. A process for producing a thiol compound, the process comprising:i) contacting:
a) an olefin compound;
b) H2S;
c) diphenylamine and/or a phenol compound comprising BHT, carvacrol, 2,2?-ethylidene-bis(4,6-di-tert-butylphenol), pentaerythritol tetrakis(3,5-di-tert-butyl-4-hydroxyhydrocinnamate), or any combination thereof; and
d) a photoinitiator and/or a free radical initiator; and
ii) forming the thiol compound.
US Pat. No. 10,188,757

CROMOLYN DERIVATIVES AND RELATED METHODS OF IMAGING AND TREATMENT

The General Hospital Corp...

1. A method for treating Alzheimer's disease in a subject in need thereof comprising the steps of:a) administering to the subject by oral inhalation a dry powder formulation consisting essentially of 17.1 mg of micronized cromolyn sodium, 12.8 mg lactose monohydrate, and 0.6 mg micronized magnesium stearate; and
b) administering orally to the subject 1 mg, 2 mg, 5 mg, 10 mg, or 25 mg of a non-steroidal anti-inflammatory drug,
wherein Alzheimer's Disease is treated in the subject.
US Pat. No. 10,189,271

NON-FOAMING AQUEOUS PARTICLE-FREE INKJET INK COMPOSITIONS

EASTMAN KODAK COMPANY, R...

1. An aqueous colorless particle-free inkjet ink composition that has a viscosity of less than 5 centipoises (0.005 N-sec) at 25° C., and comprises:an anionic polyether polyurethane having an acid number of at least 50 and an anionic acrylic polymer or anionic styrene-acrylic polymer having an acid number of at least 50; wherein the weight ratio of the anionic polyether polyurethane to the anionic acrylic polymer or anionic styrene-acrylic polymer is from 1:9 to and including 9:1, and the total amount of the anionic polyether polyurethane and the anionic acrylic polymer or anionic styrene-acrylic polymer is less than or equal to 20 weight % based on the total aqueous colorless particle-free inkjet ink composition weight, and
a defoamer that has a hydrophilic-lipophilic balance value of at least 3 and up to and including 5, which defoamer is present in an amount of at least 0.15 weight % and up to and including 1 weight %, based on the total aqueous colorless particle-free inkjet ink composition weight.
US Pat. No. 10,188,760

MODULATION OF IMMUNITY AND CEACAM1 ACTIVITY

1. A method for diagnosing a cancer in a human patient, said method comprising the step of contacting a biological sample derived from said patient with a CEACAM1 binding agent conjugated to a detectable moiety, wherein the CEACAM1 binding agent comprises a multimer agent consisting of at least two peptides selected from the group consisting of GYSWYK (SEQ ID NO:33), NRQII (SEQ ID NO:34), and QNDTG (SEQ ID NO: 35).
US Pat. No. 10,190,045

NANO-COMPOSITE STRUCTURE AND PROCESSES MAKING OF

1. A nano-composite structure comprising a nano-composite material having an amorphous matrix with embedded nano-crystallites, wherein the amorphous matrix and the nano-crystallites are made of the same chemical elements, wherein the nano-composite structure exhibits no distinguishable crystalline grain boundaries between the amorphous matrix and the nano-crystallites, wherein the nano-composite structure comprises multiple layers of nano-composite material, the multiple layers of nano-composite material disposed one directly on top of another in direct contact, and wherein each of the nano-composite layers consists of the nano-composite material.
US Pat. No. 10,189,792

METHOD AND APPARATUS FOR SYNTHESIZING A WATER-SOLUBLE HEXAARYL BIIMIDAZOLE

1. A method for forming a water-soluble hexaaryl biimidazole, comprising the steps of:a) reacting benzil with a carboxy benzaldehyde and ammonium acetate to yield a carboxy triaryl imidazole; and
b) dimerizing said carboxy triaryl imidazole in an alkaline aqueous solution of potassium ferricyanide to yield a water-soluble salt of a bicarboxy hexaaryl biimidazole,
wherein said water-soluble salt of a bicarboxy hexaaryl biimidazole is the disodium salt of 2,2?-bicarboxy hexaaryl biimidazole.
US Pat. No. 10,193,132

SYNTHESIS OF SUBMICROMETER TO MICROMETER-SIZED CATHODE MATERIALS

Washington University, S...

1. A method of producing submicrometer- to micrometer-sized, spherical-shaped cathode materials for lithium ion batteries, the method comprising:dissolving a lithium salt and a metal salt in water, alcohol, oil or a mixture of any two or more thereof, forming a lithium metal precursor solution,
spraying the precursor solution to form fine aerosolized droplets,
flowing the aerosolized droplets in a carrier medium into a pyrolysis hydrogen flame producing submicrometer- to micrometer-sized spherical lithium-metal-oxide particles in a range of from about 0.1 ?m to about 100 ?m, wherein no external heat source is required, and wherein the droplets are flowing in an environment having a temperature of less than 1200° C., wherein the submicrometer- to micrometer-sized spherical-shaped lithium-metal-oxide particles produced have a formula of Li?M??O? wherein ? is 0???1; ? is 0???2; and ? is 0???4; and wherein M? is selected from the group consisting of Ni, Co, Mn, Al, Mg, Fe, Cu, Zn, V, Mo, Nb, Cr, Si, Ti, Zr, and a mixture of any two or more thereof.
US Pat. No. 10,188,774

METHOD FOR PRODUCING ANTITHROMBOTIC COATING MATERIAL

TERUMO KABUSHIKI KAISHA, ...

1. A method for producing an antithrombotic coating material, the method comprising:preparing a methanol solution containing a monomer consisting of methoxymethyl acrylate, methoxyethyl acrylate (MEA), ethoxymethyl acrylate, ethoxyethyl acrylate, methoxymethyl methacrylate, methoxyethyl methacrylate, ethoxymethyl methacrylate, ethoxyethyl methacrylate, or a combination thereof;
adding a radical polymerization initiator having a 10-hour half-life temperature of 60° C. or less to the methanol solution to prepare a polymerization reaction liquid, wherein the radical polymerization initiator having a 10-hour half-life temperature of 60° C. or less is 2,2?-azobis(4-methoxy-2,4-dimethylvaleronitrile); and
polymerizing the monomer to form a polymer, wherein the monomer used to form the polymer consists of methoxymethyl acrylate, methoxyethyl acrylate (MEA), ethoxymethyl acrylate, ethoxyethyl acrylate, methoxymethyl methacrylate, methoxyethyl methacrylate, ethoxymethyl methacrylate, ethoxyethyl methacrylate, or a combination thereof.
US Pat. No. 10,193,134

DOPED SODIUM MANGANESE OXIDE CATHODE MATERIAL FOR SODIUM ION BATTERIES

UMICORE, Brussels (BE) U...

1. A sodium transition metal cathode material for a rechargeable sodium battery, having a P2 layered bronze crystal structure and having a composition NaxMO2, M comprising at least 55 mol % manganese, wherein the manganese valence state is at least 3.75, wherein 2/3
US Pat. No. 10,193,138

GLASS-FIBER CONTAINING COMPOSITE MATERIALS FOR ALKALI METAL-BASED BATTERIES AND METHODS OF MAKING

Johns Manville, Denver, ...

1. A method of making a glass-fiber composite, the method comprising the steps of:forming a wet laid non-woven glass fiber substrate, wherein the glass fiber substrate comprises a sodium-based compound selected from the group consisting of NaMnO2; NaNiO2; Na(Ni0.5Mn0.5)O2, NaFePO4, Na2Fe2(SO4)3, and Na2Mn11[Mn11(CN)6]; and contacting alkali-metal containing particles on the substrate.
US Pat. No. 10,189,808

SOLID FORMS OF 2-(4-CHLOROPHENYL)-N-((2-(2,6-DIOXOPIPERIDIN-3-YL)-1-OXOISOINDOLIN-5-YL)METHYL)-2,2-DIFLUOROACETAMIDE, AND THEIR PHARMACEUTICAL COMPOSITIONS AND USES

Celgene Corporation, Sum...

1. A solid form of 2-(4-chlorophenyl)-N-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)-2,2-difluoroacetamide or a tautomer thereof, which is Form C having an X-ray powder diffraction pattern comprising peaks at about 16.7, 16.9, 17.7 or 24.7 degrees 2?.
US Pat. No. 10,189,811

METHOD FOR PREPARING THE ANHYDROUS CRYSTALLINE FORM OF ISONIAZID-DERIVED HYDRAZONE, THUS PRODUCED CRISTALLINE POLYMORPH OF THE ANHYDROUS FORM, USE THEREOF FOR THE TREATMENT OF ALZHEIMER'S DISEASE, PARKINSONISM AND OTHER NEURODEGENERATIVE DISORDERS, AND PH


US Pat. No. 10,190,071

STABILIZED BLENDS CONTAINING FRICTION MODIFIERS

The Lubrizol Corporation,...

1. A composition comprising:(a) a medium comprising a solvent, a functional fluid, an additive concentrate or combinations thereof; and
(b) a friction modifier component comprising a condensation product of tartaric and/or citric acid and a linear or branched fatty alcohol of 10 to 18 carbon atoms wherein said condensation product is not fully soluble in the medium; and
(c) a stabilizing component comprising a dispersant that is soluble in (a) and that interacts with (b) such that the solubility of (b) in (a) is improved, wherein said stabilizing component is present at about 4% to about 8% by weight of said composition;
wherein component (b) is present in component (a) in the form of dispersed particles wherein no more than 10 percent by weight of the particles have a diameter of more than 0.5 microns;
wherein component (b) is present in the overall composition at a level of 2 to 4 percent by weight;
wherein component (c), the stabilizing component, comprises: (i) a nitrogen-containing dispersant comprising a reaction product of a hydrocarbyl-substituted succinic acylating agent and a polyamine; (ii) a borated nitrogen-containing dispersant comprising a reaction product of a hydrocarbyl-substituted succinic acylating agent and a polyamine which is borated; (iii) an alkyl imidazoline derived from a polyalkylene amine and a fatty mono-carboxylic acid; or combinations thereof;
wherein a N:CO ratio of (i) or (ii) ranges from greater than 1.3:1 to about 2:1; and
wherein a TBN, as defined by ASTM D4739, of (iii) is greater than 9.
US Pat. No. 10,190,072

METHOD FOR IMPROVING ENGINE FUEL EFFICIENCY

EXXONMOBIL RESEARCH AND E...

1. A method for improving fuel efficiency and reducing frictional properties, while maintaining or improving deposit control, in an engine lubricated with a lubricating oil by using as the lubricating engine oil a formulated oil, said formulated oil having a composition comprising:from 75 to 95 wt % of lubricating oil base stock selected from the group consisting of a Group I base stock, a Group II base stock, a Group III base stock, a Group IV base stock, a Group V base stock and combinations thereof;
a friction modifier mixture comprising a polymeric ethoxylated fatty acid ester having a molecular weight of greater than or equal to 2000 at from 0.1 to 1.0 wt. % of the weight of the lubricating engine oil and an organic molybdenum containing friction modifier contributing from 80 ppm to 500 ppm of elemental molybdenum based on the weight of the lubricating engine oil, and
an overbased calcium salicylate detergent contributing from 200 ppm to 2000 ppm of elemental calcium based on the weight of the lubricating engine oil;
wherein the remainder of the lubricating engine oil includes one or more other lubricating oil additives;
wherein fuel efficiency and friction reduction properties are improved (mini-traction machine (MTM) in Stribeck mode friction coefficient at 140° C. less than or equal to 0.20) and deposit control is maintained or improved (TEOST 33C total deposits less than or equal to 30 mg) as compared to friction reduction properties and deposit control achieved using the same lubricating engine oil not containing the friction modifier mixture and the overbased calcium salicylate detergent.
US Pat. No. 10,192,641

METHOD OF GENERATING A DYNAMIC PATHWAY MAP

The Regents of the Univer...

1. A processor-based method of generating a dynamic pathway map (DPM), comprising:accessing a model database that stores a probabilistic pathway model that comprises a plurality of pathway elements;
assigning an influence level for at least one pathway of a first number of the plurality of pathway elements on the basis of known attributes;
cross correlating the first number of the plurality of pathway elements;
assigning an influence level for at least one pathway on the basis of assumed attributes;
measuring a patient sample to identify measured attributes of the patient sample, based on a genome-scale assay;
modifying the probabilistic pathway model by using a plurality of the measured attributes for a plurality of elements of the patient sample, via an analysis engine, the modifying comprising:
obtaining a factor graph representing states of entities in a cell and interactions between the entities, wherein the factor graph encodes a state of the cell using a random variable for each entity and wherein the factor graph has reference pathway activity information for a particular pathway, the reference pathway indicating deviations from the probabilistic pathway model; and
formulating a treatment option for the patient based on the reference pathway activity of the factor graph, wherein at least one of the above method operations is performed through a processor.
US Pat. No. 10,190,086

METHODS OF PITCHING YEAST FOR FERMENTATION, AND RELATED METHODS OF FERMENTATION AND SYSTEMS

POET Research, Inc., Sio...

1. A method of pitching yeast for fermentation, the method comprising:providing a first aqueous composition in a first fermentation reactor, wherein the first aqueous composition comprises:
yeast;
a slurry comprising water and a processed plant material comprising an amount of at least one monosaccharide; wherein the processed plant material comprises corn flour and the slurry further comprises one or more enzymes that can break down starch in the corn flour into glucose;
fermenting the first aqueous composition in the first fermentation reactor to form a first beer composition comprising alcohol;
providing a fraction of the first beer composition to a second fermentation reactor, wherein the first beer composition in the first fermentation reactor comprises an alcohol at a concentration of at least 15 percent by volume when the fraction of the first beer composition is removed from the first fermentation reactor, and wherein the fraction of the first beer composition comprises a fraction of the yeast and the alcohol;
combining a slurry with the fraction of the first beer composition in the second fermentation reactor to form a second aqueous composition in the second fermentation reactor, wherein the slurry comprises water and a processed plant material comprising an amount of at least one monosaccharide; wherein the processed plant material comprises corn flour and the slurry further comprises one or more enzymes that can break down starch in the corn flour into glucose; and
distilling the first beer composition from the first fermentation reactor to recover alcohol.
US Pat. No. 10,191,366

ETCH VARIATION TOLERANT OPTIMIZATION

ASML Netherlands B.V., V...

1. A method to improve a lithographic process for imaging a portion of a design layout onto a substrate using a lithographic projection apparatus and for transferring the imaged portion of the design layout to the substrate by an etching process, the method comprising:determining a value of an evaluation point of the lithographic process for each of a plurality of variations of the etching process;
computing, by a hardware computer system, a multi-variable cost function of a plurality of design variables that are characteristics of the lithographic process, wherein the multi-variable cost function is a function of a deviation from the determined values of the evaluation point; and
reconfiguring one or more of the characteristics of the lithographic process by adjusting one or more of the design variables and re-evaluating the cost function, until a termination condition for the cost function is satisfied.
US Pat. No. 10,191,371

UNDERLAYER COMPOSITION AND METHOD OF IMAGING UNDERLAYER

ROHM AND HAAS ELECTRONIC ...

1. An underlayer comprising:an acid sensitive copolymer comprising:
an acid decomposable group;
an attachment group; and
a functional group; and
a photoacid generator,
where the functional group is operative to adjust neutrality of the acid-sensitive copolymer relative to a self-assembling block copolymer that is to be disposed on the underlayer, where the neutrality means that a surface energy of the underlayer is substantially the same as that of at least one block of the block copolymer;
wherein the attachment group is covalently bonded to a hydrophilic surface of a substrate by alkoxide linkages where the attachment group comprises a thiol, a primary or secondary amine substituted, a straight chain or branched C1-30 alkyl, a C3-30 cycloalkyl, a C6-30 aryl, a C7-30 alkaryl, a C7-30 aralkyl, a C1-30 heteroalkyl, a C3-30 heterocycloalkyl, a C6-30 heteroaryl, a C7-30 heteroalkaryl, a C7-30 heteroaralkyl, or a combination comprising at least one of these groups; and wherein the acid decomposable groups are ester groups, acetal groups, ketal groups, or pyrocarbonate groups.
US Pat. No. 10,190,092

PROCUREMENT OF PLACENTAL STEM CELLS

1. A method for collecting stem cells from a placenta obtained after childbirth, the method comprising:draining cord blood from the placenta obtained after childbirth;
collecting the drained cord blood in a first collection;
infusing the drained placenta with a first solution, the first solution consisting of a placental preservative base solution and prostaglandin, wherein the placental preservative base solution consists of NaCl, KCl, glucose, citric acid, adenine, histidine, glutamate, glutathione, and N-acetyl-L-cysteine;
infusing the placenta with a second solution before the first solution is collected, the second solution consisting of said placental preservative base solution, a stem cell releasing agent, an antibiotic, and an anticoagulant, wherein the stem cell releasing agent is 1, 1?-[1,4-phenylenebis (methylene)]-bis-1,4,8,11-tetraazacyclotetradecane or a pharmaceutically acceptable salt thereof;
waiting for a predetermined amount of time as the first and second solutions perfuse the placenta, wherein said predetermined amount of time is 5 minutes or fewer; and
collecting, in a second collection, said first and second solutions from the placenta, wherein the collected first and second solutions comprise stem cells from the placenta.
US Pat. No. 10,191,373

METHOD FOR PRODUCING POLYMER

SHIN-ETSU CHEMICAL CO., L...

1. A method for producing a polymer comprising recurring units having an acid generator bound to the backbone, comprisingpolymerizing monomers corresponding to the recurring units in a solution of a non-polymerizable compound containing at least one nitrogen atom to which at least one acid labile group is bound.
US Pat. No. 10,193,171

FUEL CELL WITH INTEGRATED WATER MANAGEMENT LAYER AND FABRICATION METHOD THEREOF

1. Fabrication method of a fuel cell comprising the following successive steps:providing a substrate comprising:
at least one membrane-electrode assembly, formed by an electrolytic membrane arranged between a first electrode and a second electrode,
a first current collector arranged on the first electrode,
depositing a fluoropolymer solution on the first current collector,
making a solvent of the fluoropolymer solution evaporate so as to form a porous thin layer of fluoropolymer.
US Pat. No. 10,190,095

MYELINATION OF CONGENITALLY DYSMYELINATED FOREBRAINS USING OLIGODENDROCYTE PROGENITOR CELLS

Cornell Research Foundati...

1. An in vitro method of obtaining human oligodendrocyte progenitor cells, said method comprising:providing a mixed population containing human brain or spinal cord cell types;
removing neurons and neuronal progenitor cells expressing polysialylated N-CAM (PSA-NCAM) from the mixed population to produce a treated mixed population; and
removing the oligodendrocyte progenitor cells expressing A2B5 from the treated mixed population to form an enriched population of A2B5+/PSA-NCAM? oligodendrocyte progenitor cells.
US Pat. No. 10,190,096

METHODS FOR GENERATING STEM CELL-DERIVED ? CELLS AND USES THEREOF

President and Fellows of ...

1. A method for generating stem cell-derived ? (SC-?) cells, the method comprising contacting a cell population comprising endocrine progenitor cells under conditions suitable to direct differentiation of said endocrine progenitor cells into said SC-? cells with an effective amount of an agent that decreases the level and/or activity of c-Jun N-terminal kinase (JNK), thereby generating said SC-? cells, wherein the endocrine progenitor cells comprise PDX1+/NKX6.1+/NEUROD1+/insulin+/glucagon?/somatostatin? cells.
US Pat. No. 10,190,097

METHOD AND COMPOSITION FOR INDUCING HUMAN PLURIPOTENT STEM CELLS

The Regents of the Univer...

1. A method of pluripotency reprogramming, comprising:treating a human cell with a cell culture medium comprising fibromodulin (FMOD) for a period ranging from a day to a month, and
changing the cell culture medium regularly until a FMOD reprogrammed (FreP) cell forms;
wherein the FreP cell expresses NANOG and does not form teratoma, and
wherein the human cell is a fibroblastic cell.
US Pat. No. 10,192,661

R—T—B BASED SINTERED MAGNET

TDK CORPORATION, Tokyo (...

1. A R-T-B based sintered magnet, wherein:R contains Y and R1,
Y is yttrium,
R1 is at least one rare earth element except Y but contains Nd, and
T represents at least one transition metal element containing Fe or a combination of Fe and Co,
a ratio of R1 to Y (R1:Y) in a grain boundary phase is 73:27 to 55:45 in terms of a calculated molar ratio of the grain boundary phase.
US Pat. No. 10,188,052

MAIZE PLANTS WITH IMPROVED PATHOGEN RESISTANCE

Monsanto Technology LLC, ...

1. A method of obtaining a corn plant with improved tar spot complex (TARSC) resistance, said method comprising:a) providing a population of corn plants;
b) obtaining at least one DNA sample from at least one plant within said population;
c) detecting in the DNA sample the presence of a TARSC resistance allele comprising a “T” at nucleotide position 61 of SEQ ID NO: 6 in, or genetically linked to, a chromosomal segment between about 3.99 cM and about 17.7 cM on chromosome 10;
d) selecting one or more plants from said population based on the presence of said allele;
e) crossing at least one selected plant comprising said allele with a second corn plant that comprises one or zero TARSC resistance alleles to produce one or more progeny plants that produce seeds;
f) collecting the seeds produced by the one or more progeny plants; and
g) growing from said seeds at least one plant having said allele and having improved TARSC resistance.
US Pat. No. 10,190,103

POLYPEPTIDES HAVING GLUCURONYL ESTERASE ACTIVITY AND POLYNUCLEOTIDES ENCODING SAME

1. A method for degrading or hydrolyzing a cellulosic material, comprising: contacting the cellulosic material with an enzyme composition and an isolated polypeptide having glucuronyl esterase activity to thereby degrade or hydrolyze the cellulosic material, wherein the isolated polypeptide having glucuronyl esterase activity is selected from the group consisting of:(a) a polypeptide comprising an amino acid sequence having at least 90% sequence identity to the amino acid sequence of amino acids 101 to 474 of SEQ ID NO: 2;
(b) a polypeptide encoded by a polynucleotide that hybridizes under high stringency conditions with the full-length complement of the nucleotide sequence of nucleotides 33 to 1457 of SEQ ID NO: 1, wherein the high stringency conditions are defined as prehybridization and hybridization at 42° C. in 5×SSPE, 0.3% SDS, 200 micrograms/ml sheared and denatured salmon sperm DNA, and 50% formamide, and washing three times each for 15 minutes using 2×SSC, 0.2% SDS at 65° C.;
(c) a polypeptide encoded by a polynucleotide comprising a nucleotide sequence having at least 90% sequence identity to the nucleotide sequence of nucleotides 33 to 1457 of SEQ ID NO: 1; and
(d) a fragment of the amino acid sequence of amino acids 101 to 474 of SEQ ID NO: 2, wherein the fragment has glucuronyl esterase activity.
US Pat. No. 10,188,053

HYBRID TOMATO VARIETY 72-195 RZ

RIJK ZWAAN ZAADTEELT EN Z...

1. A Solanum lycopersicum plant designated 72-195 RZ, representative seed of which having been deposited under NCIMB Accession No. 42734.
US Pat. No. 10,188,054

HYBRID TOMATO VARIETY 72-191 RZ

RIJK ZWAAN ZAADTEELT EN Z...

1. A Solanum lycopersicum plant designated 72-191 RZ, representative seed of which having been deposited under NCIMB Accession No. 42733.
US Pat. No. 10,190,105

HBV POLYMERASE MUTANTS

Transgene S.A., Illkirch...

1. A mutant polypeptide which comprises a mutated HBV polymerase domain with an internal deletion that functionally disrupts the polymerase activity, wherein said internal deletion is of at least 4 amino acid residues and at most 30 amino acid residues, wherein said mutated polymerase domain comprises the amino acid sequence shown in SEQ ID NO:1 but lacks at least the Tyr residue in position 203, the Met residue in position 204, the Asp residue in position 205 and the Asp residue in position 206, the Val residue in position 207, the Val residue in position 208, and the Leu residue in position 209.
US Pat. No. 10,193,183

NONAQUEOUS ELECTROLYTE SECONDARY BATTERIES

SANYO Electric Co., Ltd.,...

1. A nonaqueous electrolyte secondary battery comprising a positive electrode including a lithium transition metal oxide, a negative electrode including a negative electrode active material capable of storing and releasing lithium ions, and a nonaqueous electrolyte,the negative electrode active material including a carbon material as a main component,
the negative electrode including a lithium tungsten composite oxide and/or a lithium molybdenum composite oxide.
US Pat. No. 10,188,056

HYBRID TOMATO VARIETY 72-762 RZ

RIJK ZWAAN ZAADTEELT EN Z...

1. A Solanum lycopersicum tomato plant designated 72-762 RZ, representative seed of which having been deposited under NCIMB Accession No. 42810.
US Pat. No. 10,188,058

SWEET CORN HYBRID SVSK6143 AND PARENTS THEREOF

Seminis Vegetable Seeds, ...

1. A corn plant comprising at least a first set of the chromosomes of corn line SHY-6S15-9078LP or corn line SHY-6RHBE322, a sample of seed of said lines having been deposited under ATCC Accession Number PTA-124211 and ATCC Accession Number PTA-124212, respectively.
US Pat. No. 10,188,059

SOYBEAN VARIETY 5PUWT62

MONSANTO TECHNOLOGY LLC, ...

1. A plant of soybean variety 5PUWT62, wherein a sample of seed of said variety has been deposited under ATCC Accession No. PTA-125158.
US Pat. No. 10,190,110

ENGINEERED BOTULINUM NEUROTOXIN

PRESIDENT AND FELLOWS OF ...

1. A nucleic acid comprising a nucleotide sequence that encodes a polypeptide comprising a modified receptor binding domain of Clostridial botulinum serotype B, wherein the modified receptor binding domain comprises an amino acid substitution of M, Q, T or I at the amino acid position E1191 of the polypeptide of SEQ ID NO: 4, wherein the substitution produces enhanced binding of the modified receptor binding domain to human Syt II as compared to an identical molecule lacking the substitution.
US Pat. No. 10,188,060

SOYBEAN CULTIVAR S170005

M.S. Technologies, LLC, ...

1. A plant of soybean cultivar S170005, representative seed of said soybean cultivar having been deposited under ATCC Accession No. PTA-124455.
US Pat. No. 10,188,061

SOYBEAN VARIETY 01064486

Monsanto Technology LLC, ...

1. A plant of soybean variety 01064486, wherein representative seed of said soybean variety have been deposited under ATCC Accession No. PTA-124958.
US Pat. No. 10,190,112

METHOD FOR THE BIOCATALYTIC CYCLIZATION OF TERPENES AND CYCLASE MUTANTS EMPLOYABLE THEREIN

BASF SE, Ludwigshafen am...

1. An enzyme mutant with cyclase activity which is a mutant of a wild-type enzyme comprising the amino acid sequence of SEQ ID NO: 209 with a mutation at a position corresponding to position F445 of the amino acid sequence of SEQ ID NO: 209, wherein up to 10% of the amino acid residues in said enzyme mutant are altered relative to the amino acid sequence of SEQ ID NO: 209 by deletion, insertion, substitution, addition, inversion, or a combination thereof, and wherein said enzyme mutant catalyzes at least the cyclization of a citronellal isomer to at least one isopulegol isomer.
US Pat. No. 10,188,062

SOYBEAN CULTIVAR S170037

M.S. Technologies, LLC, ...

1. A plant of soybean cultivar S170037, representative seed of said soybean cultivar having been deposited under ATCC Accession No. PTA-124480.
US Pat. No. 10,188,064

PLANTS AND SEEDS OF HYBRID CORN VARIETY CH246236

Monsanto Technology LLC, ...

1. A seed of hybrid corn variety CH246236, produced by crossing a first plant of variety CV462675 with a second plant of variety CV507905, wherein representative seeds of said varieties CV462675 and CV507905 are deposited under ATCC Accession Nos. PTA-124501 and PTA-123822, respectively.
US Pat. No. 10,190,115

METHODS AND COMPOSITIONS FOR NUCLEIC ACID ANALYSIS

Bio-Rad Laboratories, Inc...

1. A composition comprising a plurality of second partitions containing first partitions, wherein:a. said first partitions are degradable upon the application of a stimulus to said first partitions such that contents of a first partition is mixed with contents of a second partition; and
b. said first partitions are contained within the second partitions;
c. said first partitions contain an oligonucleotide barcode; and
d. the first partitions have on average a first average volume and the second partitions have on average a second average volume, wherein the second average volume is at least twice as large as the first average volume.
US Pat. No. 10,188,066

MAIZE HYBRID X03M280

PIONEER HI-BRED INTERNATI...

1. A seed of hybrid maize variety X03M280, representative seed produced by crossing a first plant of variety PH42YG with a second plant of variety PH2DPY, wherein representative seed of the varieties PH42YG and PH2DPY have been deposited under ATCC Accession Numbers PTA-124780 and PTA-124001, respectively.
US Pat. No. 10,188,067

MAIZE HYBRID X08M611

PIONEER HI-BRED INTERNATI...

1. A seed of hybrid maize variety X08M611, representative seed produced by crossing a first plant of variety PH41R5 with a second plant of variety PH4257, wherein representative seed of the varieties PH41R5 and PH4257 have been deposited under ATCC Accession Numbers PTA-124793 and PTA-124803, respectively.
US Pat. No. 10,191,398

ELECTROPHOTOGRAPHIC PHOTOCONDUCTOR, IMAGE FORMING APPARATUS, AND PROCESS CARTRIDGE

Ricoh Company, Ltd., Tok...

8. An electrophotographic photoconductor, comprising:a conductive support having a volume resistivity of 1×1010?·cm or less;
an undercoat layer; and
a photoconductive layer,
wherein the undercoat layer and the photoconductive layer being disposed on the conductive support in an order mentioned,
wherein the undercoat layer comprises:
zinc oxide particles;
a urethane bond-containing resin; and
methylethyl ketone oxime,
wherein an amount of the methylethyl ketone oxime included in the undercoat layer is from 2,888 ppm to 5,000 ppm, and
wherein the undercoat layer satisfies a formula below:
10 where M is a ratio (ppm) of the methylethyl ketone oxime comprised in the undercoat layer, and L is an average thickness (?m) of the undercoat layer.
US Pat. No. 10,188,068

MAIZE HYBRID X08M612

PIONEER HI-BRED INTERNATI...

1. A seed of hybrid maize variety X08M612, representative seed produced by crossing a first plant of variety PH41V8 with a second plant of variety PH2SRH, wherein representative seed of the varieties PH41V8 and PH2SRH have been deposited under ATCC Accession Numbers PTA-124794 and PTA-124300, respectively.
US Pat. No. 10,190,119

MITOCHONDRIAL PHOSPHATE CARRIER TARGETS FOR TREATING SOFT-TISSUE CALCIFICATION

1. A method of treating soft-tissue calcification in a coronary artery or heart valve in a subject, the method comprising administering a therapeutically-effective amount of an inhibitor of solute carrier family 25 member 24 (SLC25A24) to the subject, wherein the SLC25A24 inhibitor comprises at least one small interfering RNA (siRNA) comprising a targeting sequence selected from the group consisting of: CAGAUGAAUUCACGGAAGA (SEQ ID NO: 1), GCAUAUGAACAGUACAAGA (SEQ ID NO: 2), GGAAAUGGUACAAACGUCA (SEQ ID NO: 3), and GGUGCUGUCUCUCGAACAA (SEQ ID NO: 4) wherein the SLC25A24 inhibitor decreases the expression level of SCL25A24.
US Pat. No. 10,190,631

SLIDING ENGINE COMPONENT

Mahle International GmbH,...

8. A sliding engine component according to claim 1, further comprising a plastic polymer-based layer that does not contain a thermochromic material, which is disposed between the metallic substrate and the sliding surface.
US Pat. No. 10,188,072

SOYBEAN VARIETY 01064694

Monsanto Technology LLc, ...

1. A plant of soybean variety 01064694, wherein representative seed of said soybean variety have been deposited under ATCC Accession No. PTA-124971.
US Pat. No. 10,188,074

SOYBEAN VARIETY 5PKCF87

PIONEER HI-BRED INTERNATI...

1. A plant or a seed of soybean variety 5PKCF87, representative seed of the variety having been deposited under ATCC Accession Number PTA-125527.
US Pat. No. 10,188,075

SOYBEAN VARIETY 5PKDS07

PIONEER HI-BRED INTERNATI...

1. A plant or a seed of soybean variety 5PKDS07, representative seed of the variety having been deposited under ATCC Accession Number PTA-125528.
US Pat. No. 10,188,589

DEPOSITION OF HYDROPHOBIC ACTIVES IN THE PRESENCE OF SURFACTANTS

Dow Global Technologies L...

1. A personal care composition, comprising:an anionic surfactant; and
a polyurea shell encapsulating a hydrophobic personal care active selected from the group consisting of a fragrance, a vitamin, an extract, or a therapeutic active, wherein the polyurea shell has at least one covalently attached cationic polymer, selected from the group consisting of quaternary amines and cationic biopolymers, wherein the polyurea shell has at least one covalently attached quaternary amine that is the reaction product of (2-Aminoethyl) trimethylammonium chloride and polyisocyanate.
US Pat. No. 10,189,871

TRANSITION METAL COMPLEXES FOR ENANTIOSELECTIVE CATALYSIS OF CARBON-CARBON, CARBON-HETEROATOM, AND CARBON-HYDROGEN BOND FORMING REACTIONS

1. A compound, comprising a transition metal complex having the formula ?-[M ((x,y)-L1)3?b?c((w,v)-L2)b((t,u)-L3)c]p+An?m,Z?p?m, wherein ? is ? or ?, wherein M is a transition metal, wherein p is an integer corresponding to the oxidation state of M, wherein each of x, y, w, v, t, and u independently comprises one of R and S, wherein each of L1 and L2 independently is a ligand comprising ethylene diamine, wherein L3 is EN(CH2)nNR1R2, wherein EN represents ethylene diamine, wherein n is from 2 to 4, and wherein R1 and R2 are independently H or alkyl groups, wherein c is from 1 to 3, wherein b is from 0 to 2, wherein An? comprises a lipophilic anion, wherein m is from 1 to 3, and wherein Z? comprises a second anion.
US Pat. No. 10,190,128

KITS COMPRISING PLUS-SENSE SINGLE STRANDED RNA VIRAL VECTORS AND METHODS FOR PRODUCING POLYPEPTIDES USING THE KITS

1. A kit comprisinga) a first plus-sense single stranded ribonucleic acid (RNA) viral vector, and
b) a second plus-sense single stranded RNA viral vector,
wherein
(i) the first plus-sense single-stranded viral vector and the second plus-sense single-stranded viral vector are derived from different plant viruses, and
(ii) the coat protein open reading frame (ORF) of the virus from which the first vector is derived is completely deleted in the first plus-sense single stranded RNA viral vector, and
(iii) the coat protein ORF of the virus from which the second vector is derived is completely deleted in the second plus-sense single stranded RNA viral vector, and
(iv) the first plus-sense single stranded RNA viral vector comprises a functional coat protein ORF of the virus from which the second plus-sense single-stranded viral vector is derived, and
(v) the second plus-sense single stranded RNA viral vector comprises a functional coat protein ORF of the virus from which the first plus- sense single-stranded viral vector is derived, and
(vi) the first plus-sense single-stranded viral vector and the second plus-sense single-stranded viral vector comprise an RNA replicon which is able to replicate in plant cells,
and wherein
the virus from which the first plus-sense single-stranded viral vector is derived is a Potexvirus, and
the virus from which the second plus-sense single-stranded viral vector is derived is a Tobamovirus.
US Pat. No. 10,188,591

METHOD OF ENHANCING HAIR GROWTH

ALLERGAN, INC., Irvine, ...

1. A method of growing eyebrow hair, comprising applying on at least one eyebrow an effective amount of a topical composition containing bimatoprost or a pharmaceutically-acceptable salt thereof.
US Pat. No. 10,190,129

INCREASING LEVELS OF NICOTINIC ALKALOIDS IN PLANTS

22nd Century Limited, LLC...

1. A method for increasing nicotine and yield in a Nicotiana plant, comprising:(a) crossing an increased nicotine Nicotiana plant that expresses heterologous NBB1 having the amino acid sequence set forth in SEQ ID NO: 2 and A622 having the amino acid sequence set forth in SEQ ID NO: 4 with a high yielding Nicotiana plant; and
(b) selecting progeny plant with increased nicotine and high yield, wherein the plant has an increased nicotine content and yield relative to a non-transformed control plant.
US Pat. No. 10,190,130

POLYSACCHARIDE SYNTHASES

The University of Melbour...

1. A method for decreasing the level of (1,3;1,4)-?-D-glucan produced by a plant or fungal cell, the method comprising decreasing the level and/or activity of a CslF-encoded (1,3;1,4)-?-D-glucan synthase in the cell, wherein the level and/or activity of the CslF-encoded (1,3;1,4)-?-D-glucan synthase is decreased by decreasing the expression of a CslF nucleic acid in the cell, and wherein decreasing the expression of a CslF nucleic acid in the cell results in a decrease of the level of (1,3;1,4)-?-D-glucan produced by the cell compared to a wild-type cell of the same taxon, and wherein the CslF nucleic acid comprises:(i) a nucleotide sequence set forth in SEQ ID NO: 1;
(ii) a nucleotide sequence encoding the amino acid sequence set forth in SEQ ID NO: 2; or
(iii) a nucleotide sequence encoding an amino acid sequence which is at least 90% identical to the amino acid sequence set forth in SEQ ID NO: 2.
US Pat. No. 10,189,874

DNA GRIDIRON COMPOSITIONS AND METHODS

Arizona Board of Regents ...

1. A composition, comprising:a plurality of immobile Holliday junction analogs wherein each junction comprises a 60° torsion angle linked together in a square frame having at least two layers in which the helices on opposite sides lie in the same plane, and wherein said plurality of immobile Holliday junction analogs are linked together with a central strand of single-stranded DNA within said square frame.
US Pat. No. 10,190,133

COMPOSITIONS AND METHODS FOR IMPROVING ABIOTIC STRESS TOLERANCE

China Agricultural Univer...

1. A recombinant nucleic acid, comprising:(a) the nucleotide sequence SEQ ID NO:1; or
(b) a nucleotide sequence that encodes a polypeptide comprising the amino acid sequence SEQ ID NO:28,
wherein each of the nucleotide sequences of (a) and (b) is operably linked to a heterologous promoter.
US Pat. No. 10,190,134

COMPOSITIONS AND METHODS FOR INSECTICIDAL CONTROL OF STINKBUGS

E I DU PONT DE NEMOURS AN...

1. An expression cassette, comprising a heterologous promoter operably linked to a polynucleotide encoding a double stranded RNA, wherein the double stranded RNA comprises the sense and antisense sequence of a nucleotide sequence selected from the group consisting of:(a) a nucleotide sequence comprising any one of SEQ ID NOS: 9, or 30-34;
(b) a nucleotide sequence comprising at least 95% sequence identity to any one of SEQ ID NOS: 9, or 30-34; and
(c) a nucleotide sequence comprising at least 23 consecutive nucleotides of any one of SEQ ID NOS: 9, or 30-34;
wherein said double stranded RNA has insecticidal activity against a Pentatomidae plant pest.
US Pat. No. 10,189,878

EBOLAVIRUS PRE-HAIRPIN INTERMEDIATE MIMICS AND METHODS OF USE

University of Utah Resear...

1. An Ebolavirus N-trimer mimic comprising a homotrimer of peptide monomers, wherein each peptide monomer comprises an an amino acid sequence of SEQ ID NO:23 or SEQ ID NO:21.
US Pat. No. 10,190,136

MOUSE MODEL OF ALPHA-ONE ANTITRYPSIN (AAT) DEFICIENCY

University of Massachuset...

1. A transgenic mouse whose genome comprises inactivating mutations in exon 2 of each of Serpina1a, Serpina1b, Serpina1c, Serpina1d, and Serpina1e genes, and which expresses no hepatic or circulatory Alpha-One Antitrypsin (AAT) protein.
US Pat. No. 10,190,649

FRICTION MATERIAL

AKEBONO BRAKE INDUSTRY CO...

1. A friction material comprising:a fiber base material;
a friction modifier; and
a binder,
wherein a content of copper is 0.5% by mass or less in terms of copper element,
wherein a content of the binder is 10% by mass or more,
wherein the friction material contains calcium hydroxide and zinc,
wherein the friction material has pH of 113 or more,
wherein a content of the zinc is from 1% by mass to 5% by mass,
wherein the zinc comprises a powder having an average particle diameter in a range of 1 ?m to 10 ?m,
wherein the calcium hydroxide comprises powder having an average particle diameter in a range of 5 ?m to 50 ?m,
wherein the fiber base material comprises a bio-soluble inorganic fiber, and
wherein the binder consists of at least one selected from the group consisting of an acrylic rubber-modified phenol resin, a silicone rubber-modified phenol resin, an NBR rubber-modified phenol resin, a cashew-modified phenol resin, an epoxy-modified phenol resin and an alkylbenzene-modified phenol resin.
US Pat. No. 10,189,881

MPS PEPTIDES AND USE THEREOF

The Regents of the Univer...

1. A method for one or more of: reducing, delaying, inhibiting or suppressing solid tumor cell growth or metastasis; promoting apoptosis; inhibiting cancer stem cell growth; inhibiting the PIP3 level in a tumor cell; or suppressing tumor cell mobility, the method comprising contacting the cell or tissue to be treated in vivo with an effective amount of an isolated polypeptide comprising no more than 51 amino acids, wherein the amino acid sequence comprises:XXXRYSYXXSYX (SEQ ID NO: 1) and optionally, wherein one or more serines has been substituted with a neutral or positively charged amino acid, wherein each X is a lysine and wherein each Y is a phenylalanine; or
XXXXXRYSYXXSYXLSGYSYXXNXX (SEQ ID NO: 5), and optionally a polypeptide comprising any contiguous 12 amino acid fragment thereof, and/or optionally, wherein one or more serines has been substituted with a neutral or positively charged amino acid and wherein each X is a lysine and wherein each Y is a phenylalanine.
US Pat. No. 10,190,139

METHOD FOR LACTIC ACID PRODUCTION USING MONASCUS STRAINS MODIFIED FOR LACTIC ACID PRODUCTION

1. A method of producing a composition comprising lactic acid, the method comprising:(i) providing a Monascus micro-organism that is tolerant to organic acid at a concentration of at least 50 g/L and a pH of less than 5.0 and has been genetically modified for increased production of a lactic acid by the introduction of an exogenous lactate dehydrogenase (LDH) gene; and
(ii) culturing the micro-organism in a medium having a pH less than 1.5 units above the pKa value of lactic acid in the presence of hexose, pentose, or a combination thereof, as the sole carbon source.
US Pat. No. 10,189,883

THERAPEUTIC USES OF MODIFIED FGF-21 POLYPEPTIDES

BRISTOL-MYERS SQUIBB COMP...

1. A method of decreasing or inhibiting fibrosis in a patient in need thereof, comprising administering to the patient an effective amount of a modified FGF-21 polypeptide comprising a polypeptide having at least 96% amino acid sequence identity to the amino acid sequence of SEQ ID NO: 202.
US Pat. No. 10,189,884

THIOAMIDE-MODIFIED PEPTIDES AND USES THEREOF

The Trustees of the Unive...

1. A peptide comprising the thioamide-modified amino acid sequence of SEQ ID NO:2, or a salt or solvate thereof,wherein residue 1 of SEQ ID NO:2 is the N-terminus residue of the peptide.
US Pat. No. 10,188,604

MEDICAL DEVICES INCLUDING MEDICAMENTS AND METHODS OF MAKING AND USING SAME

1. A method of treating or preventing a disease, disorder, or condition of the eye of a subject, comprising;a. providing a subject in need of treatment or prevention of said disease, disorder, or condition of the eye of said subject; and
b. providing at least one drug delivery contact lens, comprising:
i. a contact lens comprising a first surface and a second surface; and
ii. said contact lens further comprising at least one coating provided on at least a portion of said first surface, said second surface, or a combination thereof as opposed to within said contact lens;
a) said coating comprising at least one three dimensional structure;
b) said three dimensional structure comprising:
i) one or more drug reservoir layers; wherein said one or more drug reservoir layers comprise one or more drugs; and
ii) one or more barrier layers; wherein said one or more barrier layers modulafe the release of said one or more drugs from said drug delivery contact lens;
c) wherein said one or more drug reservoir layers, said one or more barrier layers, or a combination thereof, are oriented vertically, horizontally, or a combination thereof, relative to each other;
c. operably engaging said drug delivery contact lens with the eye of said subject;
wherein said one or more drugs are released from said drug delivery contact lens in an effective amount to treat or prevent a disease, disorder, or condition of the eye of said subject; and
d. wherein said subject is treated for or prevented from having or developing said disease, disorder, or condition of the eye of said subject; and
wherein said disease, disorder, or condition of the eye of said subject that is treated or prevented is an inflammation, an allergy, an infection, glaucoma, macular degeneration, a parasite, diabetes, dry eye, eye discomfort, or a combination thereof.
US Pat. No. 10,189,885

NON-HEMOLYTIC LLO FUSION PROTEINS AND METHODS OF UTILIZING SAME

The Trustees of the Unive...

1. An immunogenic composition comprising a recombinant protein comprising a listeriolysin O (LLO) protein comprising a mutation of amino acid residues on positions 2, 9 and 10 in the cholesterol-binding domain (CBD) of said LLO protein, said CBD is set forth in SEQ ID NO: 18.
US Pat. No. 10,188,605

NANOPARTICLES AND NANOPARTICLE COMPOSITIONS

Iowa State University Res...

1. An organic particle comprising a plurality of non-polymeric crosslinked amphiphiles;wherein the non-polymeric crosslinked amphiphile comprises one or more nonpolar (C6-C60)alkyl or (C6-C50)fluoroalkyl chains and one or more polar head groups;
the nonpolar chains are located on the exterior of the particle and the polar head groups are oriented toward the interior of the particle; and
the amphiphiles are covalently crosslinked to each other near the head groups through thioether groups comprising an ammonium group bonded thereto.
US Pat. No. 10,190,144

PRODUCTION OF DIRHAMNOSE-LIPID IN RECOMBINANT NONPATHOGENIC BACTERIUM PSEUDOMONAS CHLORORAPHIS

The United States of Amer...

1. A recombinant Pseudomonas chlororaphis that is derived from P. chlororaphis NRRL B-30761, said recombinant P. chlororaphis further comprises an expression vector, wherein said expression vector comprises a promoter operably linked to a heterologous polynucleotide encoding a heterologous Pseudomonas rhamnosyltransferase C, wherein rhlA and rhlB genes in said recombinant P. chlororaphis are operably linked to endogenous promoters.
US Pat. No. 10,190,402

CONTROLLING A BOTTOM-HOLE ASSEMBLY IN A WELLBORE

Halliburton Energy Servic...

1. A computer-implemented method of controlling a bottom hole assembly (BHA), the method comprising:determining, by a wellbore controller, a first candidate BHA control signal;
generating, by the wellbore controller, an input to a BHA control, the input comprising a perturbation signal superimposed on the first candidate BHA control signal;
controlling, by the wellbore controller, the BHA using the input to the BHA control;
determining, by the wellbore controller, a change in an objective value as a function of the perturbation signal, based on a received downhole sensor measurement; and
generating, by the wellbore controller and based on the change in the objective value, a second candidate BHA control signal.
US Pat. No. 10,189,890

VARIANTS OF TISSUE INHIBITOR OF METALLOPROTEINASE TYPE THREE (TIMP-3), COMPOSITIONS AND METHODS

Amgen Inc., Thousand Oak...

1. An isolated TIMP-3 mutein having a mature region that comprises the amino acid sequence of the mature region of TIMP-3 set forth in SEQ ID NO:2, wherein the mutein has(a) a mutation K45S, and
(b) a mutation F57N.
US Pat. No. 10,189,891

AFFINITY CHROMATOGRAPHY MATRIX

1. An immunoglobulin-binding protein comprising one or more mutated immunoglobulin-binding domains (monomers) of staphylococcal Protein A (E, D, A, B, C) or protein Z,wherein in at least one of the one or more mutated monomers the amino acid sequence of the monomer is defined by SEQ ID NO: 14, 16, 17, or 18.
US Pat. No. 10,190,148

METHOD FOR OBTAINING PEPTIDES

1. Method of obtaining peptides from procaryotic and/or eucaryotic cells, said method comprising the following steps:a) lysis of the procaryotic and/or eucaryotic cells at a low concentration of chaotropic agent(s) and recovery of the proteins thus obtained, wherein the lysis at a low concentration of chaotropic agent(s) comprises lysis by sonication performed by means of an ultrasound probe;
b) denaturation of said proteins using at least one denaturing agent,
wherein the denaturing agent is selected from the group consisting of chaotropic agents, thiol reducing agents, detergents, and combinations thereof, and
wherein the lysis and denaturation steps are performed simultaneously;
c) alkylation of the denatured proteins using at least one alkylating agent;
d) enzymatic proteolysis of the proteins obtained at the end of step c) using at least one proteolytic enzyme;
e) recovery of the peptides obtained at the end of the enzymatic proteolysis step d); and
wherein said method is performed under a pressure below 100 bars.
US Pat. No. 10,189,892

FERMENTATION PROCESS FOR ANTIBODY PRODUCTION

ALDERBIO HOLDINGS LLC, L...

1. A method for producing a recombinant protein in yeast cells, comprising the steps of:a) culturing under fed-batch fermentation conditions a population of yeast cells in a culture medium, wherein each yeast cell comprises a DNA segment encoding a polypeptide, wherein said DNA segment is operably linked to a glyceraldehyde-3-phosphate (GAP) transcription promoter and a transcription terminator, wherein the protein is not glyceraldehyde-3-phosphate, wherein the fermentation comprises a fermentable sugar feed at a first feed rate and wherein the fermentation is agitated at a first oxygen transfer rate;
b) measuring respiratory quotient (RQ) of the population during the batch fermentation and determining if it is within a desired predetermined range, wherein the desired predetermined range of RQ at about 20-40 hours after initiation of the culturing consists of a range between 1.08 and 1.35, which corresponds to a mixed metabolic condition wherein both aerobic and fermentative metabolism are taking place simultaneously;
c) adjusting one or both of the fermentable sugar feed rate to a second feed rate or the oxygen transfer rate to a second oxygen transfer rate, when the RQ is outside of a desired predetermined range;
d) repeating steps (b) and (c) one or more times throughout the step of culturing;
e) harvesting the yeast cells from the culture medium; and
f) recovering the polypeptide from the cells and/or the culture medium.
US Pat. No. 10,188,613

EXO-S-MECAMYLAMINE FORMULATION AND USE IN TREATMENT

UNIVERSITY OF SOUTH FLORI...

1. A method of treating a medical condition selected from the group consisting of substance addiction, Tourette's Syndrome, a neuropsychiatric disorder, depression, and anxiety, in a human in need thereof, comprising orally administering a therapeutically effective amount of a pharmaceutical composition to the human, wherein the pharmaceutical composition comprises:exo-S-mecamylamine or pharmaceutically acceptable salt thereof substantially free of exo-R-mecamylamine or a pharmaceutically acceptable salt thereof,
one or more pharmaceutically acceptable carriers; and
a pharmaceutical adjuvant, wherein the pharmaceutical composition has a higher overall therapeutic index than the same amount of exo-R-mecamylamine substantially free of exo-S-mecamylamine.
US Pat. No. 10,189,895

ANTI-CGRP COMPOSITIONS AND USE THEREOF

ALDERBIO HOLDINGS LLC, L...

1. A pharmaceutical composition comprising a humanized anti-calcitonin gene related peptide (CGRP) antibody comprising a variable light (VL) chain polypeptide comprising the complementarity-determining region (CDR) polypeptides CDR1, CDR2, and CDR3, respectively, of SEQ ID NO: 55, SEQ ID NO: 56 and SEQ ID NO: 57, and a variable heavy (VH) chain polypeptide comprising the CDR polypeptides CDR1, CDR2, and CDR3, respectively, of SEQ ID NO: 58, SEQ ID NO: 59 and SEQ ID NO: 60, and a pharmaceutically acceptable excipient.
US Pat. No. 10,190,151

HIGH-THROUGHPUT AND HIGHLY MULTIPLEXED IMAGING WITH PROGRAMMABLE NUCLEIC ACID PROBES

President and Fellows of ...

1. A method comprising(1) contacting a sample being tested for the presence of one or more targets with one or more target-specific binding partners, wherein each target-specific binding partner is linked to a docking strand, and wherein target-specific binding partners of different specificity are linked to different docking strands to produce one or more targets bound to one or more target-specific binding partners,
(2) optionally removing unbound target-specific binding partners,
(3) contacting the sample with labeled imager strands that bind to docking strands,
(4) optionally removing unbound labeled imager strands,
(5) imaging the sample to detect bound labeled imager strands,
(6) inactivating the bound labeled imager strands, by removing or modifying their signal-emitting moieties without removing the imager strand in its entirety, and
(7) repeating at least some of steps (3)-(6) at least once with a labeled imager strand having a unique composition relative to at least one other labeled imager strand of step (3).
US Pat. No. 10,188,101

METHOD FOR PRODUCING AN AGRICULTURAL PRODUCT

KAO CORPORATION, Tokyo (...

1. A method for producing an agricultural product, comprising a step of applying an agricultural chemical composition comprising (A) at least one compound selected from the group consisting of the following (A1) to (A5); (B) at least one compound selected from the group consisting of the following (B1) and (B2); and an agricultural chemical ingredient selected from the group consisting of active ingredients in bactericides, pesticides, miticides, herbicides and plant growth regulators to a subject sensitive to the agricultural chemical ingredient:(A1): a polyoxyethylene alkyl ether represented by the formula (A1):
R1aO-(EO)l—R2a  (A1)
wherein, R1a represents a linear or branched, alkyl or alkenyl group having 10 to 16 carbon atoms; EO represents an ethyleneoxy group; 1 represents an average mole number of ethyleneoxy groups added, ranging from 3 to 40; and R2a represents a hydrogen atom or a methyl group,
(A2): a polyoxyethylene fatty acid ester,
wherein a fatty acid group has 8 to 16 carbon atoms; and an average number of moles of ethylene oxide added per mole of fatty acid is 5 to 40,
(A3): a polyoxyethylene sorbitan fatty acid ester,
wherein a fatty acid group has 8 to 16 carbon atoms; and an average number of moles of ethylene oxide added per mole of fatty acid is 5 to 40,
(A4): a (poly)glycerol fatty acid ester,
wherein a fatty acid group has 8 to 16 carbon atoms; and an average condensation degree of glycerol is 1 to 3, and
(A5): an alkyl saccharide represented by the formula (A5):
R3a—O-(G)p  (A5)
wherein R3a represents an alkyl group having 8 to 16 carbon atoms; G represents a reducing sugar group having 5 to 6 carbon atoms; and p represents a number of 1 to 10;
(B1): a polyoxyalkylene alkyl ether represented by the formula (B1):
R1bO—[(PO)m/(EO)n]—R2b  (B1)
wherein, R1b represents a linear or branched, alkyl or alkenyl group having 6 to 12 carbon atoms; PO represents a propyleneoxy group; EO represents an ethyleneoxy group; m represents an average mole number of propyleneoxy groups added, ranging from 2 to 20; n represents an average mole number of ethyleneoxy groups added, which is 0; and R2b represents a hydrogen atom or a methyl group; wherein “/” means that PO and EO groups may be arranged at random or in blocks, and
(B2): an aliphatic alcohol represented by the formula (B2):
R3b—OH  (B2)
wherein R3b represents a linear or branched, alkyl group having 8 to 10 carbon atoms, and wherein a weight ratio of compounds (A) to (B), (A)/(B), is 0.5 to 8.
US Pat. No. 10,190,152

METHODS AND COMPOSITIONS FOR DIRECT CHEMICAL LYSIS

Becton, Dickinson and Com...

1. A composition consisting of a direct chemical lysis composition in combination with a liquid-based cytology sample or a formalin-fixed, paraffin embedded sample, the direct chemical lysis composition consisting of:a) a buffer composition comprising a buffer component and a metal salt component, wherein the metal salt component is selected from the group consisting of sodium chloride (NaCl), potassium chloride (KCl), sodium acetate (C2H3NaO2) and ammonium sulfate ((NH4)2SO4), wherein a concentration of the buffer component is in a range of 0.2 M to 2 M and a concentration of the metal salt component is in a range of 0.01 M to 1 M; and
b) a non-ionic surfactant wherein a concentration of the non-ionic surfactant is in a range of 0.01 to 2 percent (v/v).
US Pat. No. 10,188,615

ALKOXY COMPOUNDS FOR DISEASE TREATMENT

ACUCELA INC., Seattle, W...

1. A method of modulating chromophore flux in a retinoid cycle comprising introducing into a subject a non-retinoid aromatic compound that inhibits 11-cis-retinol production with an IC50 of about 0.1 micromolar or less when assayed in vitro, the assay consisting of a homogenate of HEK293 cell clone expressing recombinant human RPE65 and LRAT as the source of visual enzyme, exogenous all-trans-retinol in the amount of about 20 ?M, recombinant human CRALBP in the amount of about 80 ?g/mL, about 10 mM pH 7.2 phosphate buffer, about 0.5% BSA and about 1 mM NaPPi, and wherein the amount of assay reaction product 11-cis-retinol being determined by HPLC analysis following heptane extraction of the assay reaction mixture and wherein the non-retinoid aromatic compound consists of a benzene core that is substituted with a first substituent, a second substituent, and an optional third substituent, wherein the first and second substituents are attached to the benzene core in a meta-substitution configuration, wherein the first substituent is a group selected from —CH(OH)CH(R)CH2NH2 wherein R is H, CH3, or —OH and the second substituent is an optionally substituted alkoxy group, and wherein the optional third substituent is a halogen or —OH.
US Pat. No. 10,190,153

METHODS FOR PREPARATION OF NUCLEIC ACID-CONTAINING SAMPLES USING CLAY MINERALS AND ALKALINE SOLUTIONS

MICRONICS, INC., Redmond...

1. A method for treating a nucleic acid-containing sample for analysis of nucleic acids, the method comprising the steps of:a) contacting the sample with a clay mineral, wherein the clay mineral comprises a kaolinite, a smectite or a synthetic clay mineral and the sample is selected from the group consisting of blood, plasma and serum;
b) mixing the sample and the clay mineral until the clay mineral is evenly dispersed in the sample;
c) substantially removing the clay mineral from the sample;
d) contacting the sample with an alkaline solution at a pH suitable for lysis of cell and viral particles to form a nucleic acid solution; and
e) optionally, contacting the nucleic acid solution with an acidic solution suitable for neutralizing the pH of the nucleic acid solution.
US Pat. No. 10,188,617

MODULATION OF CELLULAR DNA REPAIR ACTIVITY TO INTERCEPT MALIGNANCY

The Board of Trustees of ...

1. A method of reducing the risk of cancer in a subject having a mutation in BRCA1, comprising administering to said subject an effective amount of a DNA repair agent which is benserazide.
US Pat. No. 10,189,902

ANTIBODIES TO TIGIT

Bristol-Myers Squibb Comp...

1. An isolated antibody, or antigen binding fragment thereof, that binds to human TIGIT (human T cell immunoreceptor with Ig and ITIM domains) comprising:a) a heavy chain comprising a heavy chain variable domain comprising:
i) CDRH1 comprising the sequence of SEQ ID NO.: 20;
ii) CDRH2 comprising the sequence of SEQ ID NO.: 21; and
iii) CDRH3 comprising the sequence of SEQ ID NO.: 22;
and
b) a light chain comprising a light chain variable domain comprising:
iv) CDRL1 comprising the sequence of SEQ ID NO.: 23;
v) CDRL2 comprising the sequence of SEQ ID NO.: 24; and
vi) CDRL3 comprising the sequence of SEQ ID NO.: 25.
US Pat. No. 10,189,903

BISPECIFIC CHIMERIC ANTIGEN RECEPTORS AND METHODS OF USE THEREOF TO TREAT CANCER

1. A bispecific chimeric antigen receptor, comprising:a. at least two antigen-specific targeting regions;
b. an extracellular spacer domain;
c. a transmembrane domain;
d. at least one co-stimulatory domain; and
e. an intracellular signaling domain,
wherein each antigen-specific targeting region comprises a single-domain antibody.
US Pat. No. 10,189,904

ANTIBODIES THAT BIND AND BLOCK TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS-1 (TREM-1)

1. An isolated antibody or fragment thereof, which competes with mAb 0170 for binding to a triggering receptor expressed on myeloid cells-1 (TREM-1) having an amino acid sequence set forth as SEQ ID NO: 1 (human TREM-1), SEQ ID NO: 12 or SEQ ID NO: 21 (cynomolgus monkey TREM-1),wherein the antibody or fragment thereof comprises a heavy chain variable region that comprises CDR1, CDR2, and CDR3 domains; and a light chain variable region that comprises CDR1, CDR2, and CDR3 domains, and
wherein the heavy chain variable region CDR1 domain comprises amino acid residues 31 to 35 of SEQ ID NO: 4, the heavy chain variable region CDR2 domain comprises amino acid residues 50 to 68 of SEQ ID NO: 4, the heavy chain variable region CDR3 domain comprises amino acid residues 101 to 110 of SEQ ID NO: 4, the light chain variable region CDR1 domain comprises amino acid residues 24 to 38 of SEQ ID NO: 5, the light chain variable region CDR2 domain comprises amino acid residues 54 to 60 of SEQ ID NO: 5, and the light chain variable region CDR3 domain comprises amino acid residues 93 to 101 of SEQ ID NO: 5.
US Pat. No. 10,189,906

ANTIBODY THAT BINDS CD269 (BCMA) SUITABLE FOR USE IN THE TREATMENT OF PLASMA CELL DISEASES SUCH AS MULTIPLE MYELOMA AND AUTOIMMUNE DISEASES

1. A method for the treatment of a medical disorder in a human subject, wherein the medical disorder is associated with the presence of pathogenic B cells expressing B cell maturation antigen (BCMA), the method comprising administering to the human subject an isolated monoclonal antibody or an antigen binding fragment thereof that binds CD269 (BCMA), wherein said antibody or antigen binding fragment thereof comprises:(i) a VH domain, wherein said VH domain comprises CDR H1 comprising SEQ ID No. 1 (RYWMS) or SEQ ID No. 15 (DYWMS), CDR H2 comprising SEQ ID No. 2 (EINPDSSTINYAPSLKD) or SEQ ID No. 16 (EINPDSSTINYAPSLKG) and CDR H3 comprising SEQ ID No. 3 (SLYYDYGDAMDYW), and
(ii) a VL domain, wherein said VL domain comprises CDR L1 comprises SEQ ID No. 4 (KASQSVDSNVA), CDR L2 comprises SEQ ID No. 5 (SASLRFS) or SEQ ID No. 17 (SDDLRFS) and CDR L3 comprises SEQ ID No. 6 (QQYNNYPLTFG),
wherein the medical disorder associated with the presence of pathogenic B cells is a cancer of plasma cells or a cancer of B lymphocytes.