US Pat. No. 10,510,181

SYSTEM AND METHOD FOR CACHE MANAGEMENT USING A CACHE STATUS TABLE

SAMSUNG ELECTRONICS CO., ...

1. A clip-cull-viewport (CCV) unit, the CCV unit comprising:an input interface coupled to a CCV pipeline to receive a plurality of primitives, each primitive comprising a plurality of vertices, a first attribute field and a first index field, the first attribute field indicating whether each vertex of the primitive is a new vertex or a used vertex, and the first index field indicating where in an index cache each vertex of the primitive is to be written;
an output interface coupled to the CCV pipeline to output primitives that survive culling to a downstream unit from the CCV unit; and
a control unit coupled to the input interface and to the output interface, the control unit comprising the index cache and a cache-status table, the cache-status table corresponding to an index cache in the downstream unit and includes entries that correspond to entries in the index cache in the downstream unit, each entry in the cache-status table including a valid indicator that indicates whether a vertex stored in the entry is a valid vertex, the control unit in response to receiving a first primitive at the input interface to
store the vertices of the first primitive in locations within the index cache based on the first attribute field and the first index field of the first primitive, and
determine whether a vertex of the first primitive that is a reused vertex of another primitive based on the first attribute field matches a valid entry in the cache-status table,
the control unit to preserve the valid entry in the cache-status table, set a second attribute field of the first primitive to indicate that the reused vertex corresponding to the valid entry in the cache-status table is a reused vertex, and send the first primitive, the second attribute field and a second index field to the output interface to output the first primitive to the downstream unit based on the reused vertex matching a valid entry in the cache-status table and the first primitive surviving being culled, the second index field indicating an address in the cache-status table of the valid entry matching the reused vertex, and
the control unit to determine a first non-preserved entry in the cache-status table and set the second index field to an address in the cache-status table of the first non-preserved entry, to set the second attribute field to indicate that the reused vertex that does not match a valid entry in the cache-status table is now not reused, and send the first primitive, the second attribute field and the second index field to the output interface to output the first primitive to the downstream unit based on the reused vertex not matching a valid entry in the cache-status table and the first primitive surviving being culled.

US Pat. No. 10,509,873

SYSTEM AND METHOD FOR AUTOMATED MODEL CALIBRATION, SENSITIVITY ANALYSIS, AND OPTIMIZATION

UNIVERSITY OF FLORIDA RES...

18. A computer-implemented method for automated sensitivity analysis or optimization of a model, the method comprising:providing one or more selectable input parameters for display via an interface;
receiving a selection of at least one input parameter of the one or more selectable input parameters and a corresponding search thoroughness level, wherein the selection of the at least one input parameter is input via the interface;
in response to receiving a selection for the model to initiate one of automated sensitivity analysis or optimization of the selected at least one input parameter, executing one or more trials by selecting one or more default values available for the selected at least one input parameter;
archiving, during execution of the one or more trials, a dynamically updated list of one or more completed trials; and
providing an option for displaying, via the interface, at least one of the archived one or more completed trials.

US Pat. No. 10,509,627

USER INTERFACE SOUND EMANATION ACTIVITY CLASSIFICATION

International Business Ma...

1. A method comprising:obtaining an audio input, the audio input representing sound emanating from a key press based user interface;
generating a context pattern based on the audio input;
performing classification of the context pattern to classify the context pattern as belonging to a signature pattern classification, wherein the signature pattern classification specifies a user activity; and
providing an output based on the performing classification, wherein the performing classification results in classification failure, wherein the method includes prompting a user to enter activity information in response to the classification failure, and wherein the prompting includes providing user interface functionality that prompts the user to enter activity specifying information that specifies an activity engaged in by the user resulting in the generating of the context pattern, and wherein the method includes, using data received from the user in response to the prompting, registering the context pattern as a new signature pattern for comparison to subsequent context patterns.

US Pat. No. 10,509,458

INFORMATION DEVICE WITH IMPROVED OPERATING MODES

LENOVO (SINGAPORE) PTE. L...

1. An information processing device, which has a standby mode and a normal operation mode, comprising:a display;
a processor which executes at least a standby mode when a display of the display portion turns off and a normal operation mode when the display turns on, wherein:
the standby mode has a first low power consumption state and a first operating state to which the first low power consumption state can switch, and in which background processing is executed, and
the normal operation mode has a second operating state;
a combined service/utility, driver and bios (mode control portion) that changes a mode between the standby mode and the normal operation mode; and
a power driver (power setting processing portion) that sets an upper limit power consumption when the mode of the processor is changed, wherein:
when the mode control portion changes the mode to the standby mode, the power setting processing portion sets a first upper limit power consumption in the first operating state, and when the mode control portion changes the mode to the normal operation mode, the power setting processing portion sets a second upper limit power consumption in the second operating state greater than the first upper limit power consumption.

US Pat. No. 10,509,330

METHOD AND DEVICE FOR CHARACTERIZING A WAFER PATTERNED USING AT LEAST ONE LITHOGRAPHY STEP

Carl Zeiss SMT GmbH, Obe...

1. A method, comprising:a) simultaneously performing intensity measurements of electromagnetic radiation diffracted at a used structure of a patterned wafer and at a plurality of auxiliary structures of the patterned wafer, wherein:
the intensity measurements of the electromagnetic radiation diffracted at the used structure of the patterned wafer are performed for at least one member selected from the group consisting of a wavelength of the electromagnetic radiation diffracted at the used structure of the patterned wafer, a polarization of the electromagnetic radiation diffracted at the used structure of the patterned wafer, and an order of diffraction of the electromagnetic radiation diffracted at the used structure of the patterned wafer; and
the measured intensity of the electromagnetic radiation diffracted at the plurality of auxiliary structures of the patterned wafer are performed for at least one member selected from the group consisting of a wavelength of the electromagnetic radiation diffracted at the plurality of auxiliary structures of the patterned wafer, a polarization of the electromagnetic radiation diffracted at the plurality of auxiliary structures of the patterned wafer, and an order of diffraction of the electromagnetic radiation diffracted at the plurality of auxiliary structures of the patterned wafer; and
b) determining a plurality of parameters characteristic of the patterned wafer based on:
i) the intensity measurements of the electromagnetic radiation diffracted at the used structure of the patterned wafer and at the plurality of auxiliary structures of the patterned wafer; and
ii) correspondingly calculated intensity values via a mathematical optimization method,
wherein determining the parameters characteristic of the patterned wafer comprises:
determining parameters of a first parameter set based on the measured intensity values for the electromagnetic radiation diffracted from the plurality of auxiliary structures; and
determining parameters of a second parameter set taking account of the parameters of the first parameter set.

US Pat. No. 10,509,205

CAMERA OPTICAL LENS

AAC Technologies Pte. Ltd...

1. A camera optical lens comprising, from an object side to an image side in sequence: a first lens, a second lens, a third lens, a fourth lens, a fifth lens, a sixth lens and a seventh lens, wherein the fifth lens has a negative refractive power with a concave object side surface and a convex image side surface; the camera optical lens further satisfies the following conditions:1.05f1/f1.5;
1.7n22.2;
?2f3/f42;
?10(R13+R14)/(R13?R14)10;
0.01d3/TTL0.05;
?107.04f5/f5?24.91;
?41.21(R9+R10)/(R9?R10)?0.95;
0.10 mmd90.41 mm; where
f: the focal length of the camera optical lens;
f1: the focal length of the first lens;
f3: the focal length of the third lens;
f4: the focal length of the fourth lens;
f5: the focal length of the fifth lens;
n2: the refractive index of the second lens;
R9: the curvature radius of the object side surface of the fifth lens;
R10: the curvature radius of the image side surface of the fifth lens;
R13: curvature radius of object side surface of the seventh lens;
R14: the curvature radius of image side surface of the seventh lens;
d3: the thickness on-axis of the second lens;
d9: the thickness on-axis of the fifth lens;
TTL: the total optical length of the camera optical lens.

US Pat. No. 10,509,159

LIGHT SOURCE MODULE AND BACKLIGHT ASSEMBLY HAVING THE SAME

Samsung Electronics Co., ...

1. A light source module, comprising:a first substrate including,
a plurality of connectors configured to at least receive a supply of electrical power, and
a plurality of first connection pads configured to be electrically connected to the plurality of connectors;
a plurality of second substrates on the first substrate, each second substrate including,
a plurality of light-emitting devices on an upper surface of the second substrate, wherein each light-emitting device is a chip,
a plurality of second connection pads on a lower surface of the second substrate, the plurality of second connection pads configured to be electrically connected to the plurality of light-emitting devices, the lower surface of the second substrate being on an opposite side of the second substrate in relation to the upper surface of the second substrate, and
a plurality of vias extending through an interior of the second substrate between the lower surface of the second substrate and the upper surface of the second substrate, the plurality of vias configured to electrically connect the plurality of light-emitting devices to separate, respective sets of second connection pads of the plurality of second connection pads; and
a plurality of connection members configured to electrically connect the plurality of first connection pads of the first substrate with the plurality of second connection pads of the plurality of second substrates.

US Pat. No. 10,509,022

SYSTEM FOR IMAGING CAPTURED CELLS

Celsee Diagnostics, Inc.,...

1. A system for biological sample analysis, the system comprising:a platform including a set of guides that receive a set of imaging substrates at a broad surface of the platform;
a filter module superior to the platform including an excitation filter, an emission filter, and a dichroic mirror;
a first light source, inferior to the platform, configured to transmit light toward an imaging substrate of the set of imaging substrates from a first direction;
a second light source configured to transmit light through the excitation filter, to be reflected from the dichroic mirror, and to reach imaging substrate from a second direction opposed to the first direction;
a lens, coupled to a lens selector, that focuses light from the excitation filter onto a target object of the imaging substrate, and transmits light from the target object, through the dichroic mirror and the emission filter, toward an optical sensor;
a platform control module comprising a platform actuator coupled to the platform and configured to translate the platform within a plane perpendicular to an axis, into a first configuration that aligns at least one imaging substrate between the first light source and the lens; and
a filter stage, situated superior to the platform, configured to rotate the filter module about the axis, into a second configuration that positions the filter module to receive light from the second light source and to transmit light toward the optical sensor.

US Pat. No. 10,508,718

INTERNAL COMBUSTION ENGINE

HONDA MOTOR CO., LTD., T...

1. An internal combustion engine comprising:a driving sprocket (45) integrally rotatable with a crankshaft (20);
a driven sprocket (46) integrally rotatable with a camshaft (41) driving a valve train (40);
a cam chain (47) wound between the driving sprocket (45) and the driven sprocket (46) and transferring power of the crankshaft (20) to the camshaft (41);
a cam chain tensioner (51) for pressing the cam chain (47) at a position between the driving sprocket (45) and the driven sprocket (46);
a tensioner lifter (60) for pressing the cam chain tensioner (51) with a predetermined pressure; and
a driving-sprocket cam chain guide (70) for guiding the cam chain (47) along the driving sprocket (45);
wherein, as viewed in a crankshaft axial direction, the driving-sprocket cam chain guide (70) includes a guide body (71) extending beyond a winding termination point (P) of the cam chain (47) on the driving sprocket (45) to a position adjoining a chain moving surface (52a) of the cam chain tensioner (51), on which the cam chain (47) slides.

US Pat. No. 10,508,419

RAINWATER COLLECTION DEVICE

1. A rainwater distribution system comprisinga reservoir, a distribution system, a plurality of hoses, and a cart;
wherein the reservoir, the distribution system, and the plurality of hoses mount on the cart;
wherein the rainwater distribution system collects accumulated rainfall from one or more storage containers into the reservoir;
wherein the rainwater distribution system pumps the accumulated rainfall from the reservoir for use in irrigation;
wherein the accumulated rainfall refers to water collected from rainfall run off by the one or more storage containers;
wherein the distribution system comprises a plurality of valves, a plurality of check valves, a pump, a filter, a battery, and a plurality of switches;
wherein the plurality of switches comprises a supply switch, a release switch, a pump maintenance switch, and a pump power switch;
wherein the plurality of valves comprises a supply feed valve, an irrigation valve, a reservoir feed valve, a reservoir discharge valve, a pump intake maintenance valve, and a pump discharge maintenance valve;
wherein the supply switch simultaneously actuates the supply feed valve and the reservoir feed valve;
wherein the release switch simultaneously actuates the irrigation valve and the reservoir discharge valve;
wherein the pump maintenance switch simultaneously actuates the pump intake maintenance valve and the pump discharge maintenance valve;
wherein the pump power switch operates the pump.

US Pat. No. 10,508,382

SQUEEZE PIN

1. A squeeze pin, comprising:a spring-wire structure having an upper horizontal span;
mirror-image side portions extending downward from opposite ends of the upper horizontal span; and
lower portions proceeding from lower ends of the side portions first inward, and then back outward, ending at sharp engagement points presented in opposite directions, substantially parallel with the upper horizontal span;
wherein the spring-wire structure lies within a plane.

US Pat. No. 10,508,071

METHOXYCARBONYLATION WITH FORMIC ACID AND METHANOL

EVONIK DEGUSSA GMBH, Ess...

1. A process for the methoxycarbonylation of alkenes to form a methyl ester of an acid that corresponds to the alkene comprising the process steps of:a) adding an olefin to form a reaction mixture;
b) introducing to the mixture a compound comprising Pd, wherein the Pd is capable of forming a complex;
c) introducing to the mixture a compound of general formula (I):

wherein R1, R2, R3 and R4 are each independently selected from the group consisting of: -H, -(C1-C12)-alkyl, -O-(C1-C12)-alkyl, -(C4-C14)-aryl, -O-(C4-C14)-aryl, cycloalkyl, -(C1i-C12)-heteroalkyl, -O-(C1-C12)- heteroalkyl, -(C3-C14) heteroaryl, -O-(C3-C14)-heteroaryl, -COO-alkyl, -COO-aryl, -C-O-alkyl, C-O-aryl, NH2, and halogen;
wherein the recited alkyl groups, aryl groups, cycloalkyl, heteroalkyl groups and heteroaryl groups may be substituted with:
-(C1-C12)-alkyl, -O-(C1-C12)-alkyl or halogen; and at least one of the radicals R1, R2, R3 and R4 does not represent phenyl;
d) introducing to the mixture MeOH;
e) introducing to the mixture HCOOH,
wherein the employed volume of HCOOH based on 2 mmol of olefin is in the range from 0.3 ml to 0.8 ml:
f) heating of the reaction mixture to convert the olefin, MeOH and HCOOH into the methyl ester where no CO gas is supplied to the reaction mixture.

US Pat. No. 10,507,959

CHILD RESISTANT SEALING SYSTEM

QUARK DISTRIBUTION, INC.

1. A container having a top end with an opening therein and a bottom end opposite the top end, and at least first and second sides between the top and bottom ends of the container, the container comprising:a first layer of sheet material forming the first side of the container and at least a second and third layer of sheet material forming the second side of the container,
a closure strip assembly extending along the opening of the container, the closure strip assembly comprising a first set of interlocking strip halves having at least a first half and a second half, the closure strip assembly further comprising:
an extension above and an extension below the first half, and
an extension below the second half,
wherein the second layer of sheet material is attached to the closure strip assembly at the extension below the one of the first half therewith forming a first upward extending flap, the first layer of sheet material is attached to the closure strip assembly at the extension below the second half therewith forming a second upward extending flap, and the third layer of sheet material is attached to the closure strip assembly at the extension above the first half therewith forming a third upward extending flap, wherein the second flap extends upward of the third layer to form a lateral slit between the second and third layers of sheet material that does not provide access to the inside of the container, wherein the first set of interlocking strip halves are configured such that when engaged with each other pulling apart any of the flaps other than the first and second flaps resists the first set of interlocking strip halves from being released from each other, the container is therewith capable of being opened at the closure strip assembly by pulling the first and second flaps apart.

US Pat. No. 10,507,470

METHOD OF SORTING TRASH FOR RECYCLING OF PAPER AND APPARATUS FOR SORTING TRASH FOR PAPER RECYCLING

Van Dyk Baler Corp., Sta...

1. A garbage processing apparatus comprising:at least one sorter configured to sort paper from garbage fed to the sorter, the paper having a moisture content that is above a pre-selected threshold;
at least one dryer having a chamber configured to receive the paper sorted from the garbage to heat the paper to reduce the moisture content of the paper to being at or below the pre-selected threshold; a sensor positioned to measure the moisture content of the paper in the chamber
wherein the dryer is comprised of at least one arm that is moveable within the chamber of the dryer to agitate the paper as the paper is heated and the dryer is configured to clean the paper as the paper is heated therein;
wherein the dryer is also comprised of a grate, the grate having holes in communication with the chamber sized and configured so that hot air is passable into the chamber via the holes for heating the paper and dirt that is removed from the paper as the paper is heated in the chamber is also passable through the holes for exiting the chamber of the dryer.

US Pat. No. 10,507,407

METHODS TO REDUCE CHLOROPHYLL CO-EXTRACTION THROUGH EXTRACTION OF SELECT MOIETIES ESSENTIAL OILS AND AROMATIC ISOLATES

Capna IP Capital, LLC, S...

1. A safer and more reliable extraction process for extracting a plant substrate comprising, in combination,(i) pre-processing comprising lowering the temperature of a solvent to a range of ?30 degrees C. and ?50 degrees C.,
(ii) contacting at ?30 degrees C. and ?50 degrees C. wherein there is a contacting time between the plant substrate and the solvent to create an emulsion,
(iii) evaporating for reduction of the emulsion by means of atmospheric evaporation of the solvent,
(iv) recovering for recovery of the solvent from the emulsion,
(v) purging whereby a resultory extract is substantially free of any lipids and chlorophyll.

US Pat. No. 10,507,393

COLLABORATIVE MOBILE MUSIC GAMING COMPUTER APPLICATION

Bryan A. Brooks, Long Is...

1. A method for collaboratively implementing a mobile music gaming computer application which comprises the steps of:connecting a host mobile device with a music streaming media service;
inviting an m number of available user mobile devices to join the host device for a game;
setting an n number of rounds for the game;
picking a music genre for each round;
selecting an m number of respectively different music tracks from the music genre for inclusion in each round;
identifying a favorite music track for each user device in each round;
playing the n number of rounds in a predetermined sequence;
voting by each individual user device on each music track in a round, wherein each vote is numerically weighted by the user device, and wherein each music track in a round is given a different weighted vote from a same user device;
totaling the weighted votes for the favorite music track for each user device in each round; and
tabulating the weighted votes for each user device during the n rounds of the game to determine a winner.

US Pat. No. 10,507,391

INFORMATION PROCESSING SYSTEM, INFORMATION PROCESSING APPARATUS, STORAGE MEDIUM HAVING STORED THEREIN INFORMATION PROCESSING PROGRAM, AND INFORMATION PROCESSING METHOD

NINTENDO CO., LTD., Kyot...

1. An information processing system comprising at least one computer processor,the at least one computer processor configured to:
manage placement states of a plurality of objects in a virtual space;
manage a first parameter that is changed in accordance with an instruction given by a player;
receive a change instruction to change the placement state of a selection object selected among the plurality of objects by the player; and
when the change instruction is given and under the condition that a first parameter condition, which is a condition satisfied when the first parameter is equal to or greater than a predetermined value, or a condition satisfied when the first parameter is less than or equal to a predetermined value, is satisfied, change the first parameter such that in a case where the first parameter condition is the condition satisfied when the first parameter is equal to or greater than the predetermined value, the first parameter is reduced, and in a case where the first parameter condition is the condition satisfied when the first parameter is less than or equal to the predetermined value, the first parameter is increased, wherein
the computer processor configured to manage the placement states:
executes a first change process for changing the placement state of at least one change target object among the plurality of objects in the virtual space in accordance with time;
executes a second change process for, when the change instruction is given and under the condition that the first parameter satisfies the first parameter condition, changing the placement state of the selection object in the virtual space;
in the first change process, causes the change target object to appear in the virtual space; and
in the second change process, causes the selection object to appear in the virtual space.

US Pat. No. 10,507,384

GAME SYSTEM, GAME APPARATUS, STORAGE MEDIUM STORING GAME PROGRAM AND GAME DATA EXCHANGE METHOD

Nintendo Co., Ltd., Kyot...

1. A method for performing wireless radio communication, the method comprising:alternately repeating the functioning of an apparatus in a first mode and in a second mode,
wherein the first mode includes the apparatus broadcasting data capable of being received by other apparatuses functioning in the second mode;
wherein in the second mode, broadcasted data from other apparatuses functioning in the first mode is receivable by the apparatus; and
wherein the length of the period in which the apparatus functions in the first mode and/or the length of the period in which the apparatus functions in the second mode is/are determined at random.

US Pat. No. 10,507,380

MULTI-STAGE PROGRESSIVE RISK MINI GAME

Zynga Inc., San Francisc...

1. A system comprising: one or more computer processors; one or more computer memories; a set of instructions incorporated into the one or more computer memories, the set of instructions configuring the one or more computer processors to perform operations for temporarily overlaying a user interface of a secondary game of a game networking system over a user interface of a primary game of the name networking system,the operations comprising: based on a determination that a criterion for initiating the secondary game has been satisfied, presenting a selectable user interface control to provide a player with an opportunity to access the secondary game;
based on a selection of the selectable user interface control, performing the temporary overlaying of the secondary game over the primary game, the temporary overlaying including providing additional selectable user interface controls for playing the secondary game and for terminating the secondary game;
and based on a determination that a criterion for terminating the secondary game has been satisfied, terminating the secondary game and automatically returning the player to the primary game,
wherein the criterion for initiating the secondary game is that the player purchased a virtual asset having a value that transgresses a threshold value.

US Pat. No. 10,507,373

AUTOMATIC JUDGING SYSTEM FOR CLIMBING WALL COMPETITION

1. An automatic judging and display system for rock climbing competition comprising:a rock climbing wall;
first and second sets of spaced apart holds secured to said wall, each of said sets including a plurality of holds, said first set of holds being associated with a first color and said second set of holds being associated with a second color, different from said first color;
a plurality of distinct RFID tags, each tag having a different identification associated therewith, each tag being located near and associated with a different hold, each tag uniquely identifying only the hold to which it is associated;
an RFID tag reader, said tag reader being capable of separately identifying each of said tags and including means for wirelessly transmitting a signal containing information relating to a tag when brought into the vicinity of said tag;
a computer system, said computer system being capable of receiving signals from said RFID tag reader and analyzing said signals, and
means for attaching said RFID tag reader to a climber's body.

US Pat. No. 10,507,371

HANDLE FOR A COGNITIVE TRAINING DEVICE AND COGNITIVE TRAINING DEVICE COMPRISING SAME

BC TRAINING, BRAIN CENTRE...

1. A cognitive training handle arranged to be connected by a longitudinal connecting means to a connection means on a ball, said handle further comprising adjusting means for adjusting the length of said longitudinal connecting means, said handle being characterized in that said adjusting means comprises:two side walls,
a series of alternating retaining regions and passage regions between the two side walls,
wherein the two side walls are connected to one another by a junction zone,
wherein the retaining regions are regions where the two side
walls are spaced apart from one another by a first dimension d at least smaller than a diameter of said longitudinal connecting means so as to jam said connecting means when the latter is introduced between the two side walls of said adjusting means, and
wherein the passage regions are regions where the two side walls are spaced apart from one another by a second dimension d at least larger than said diameter of said longitudinal connecting means,
the handle comprising an outer case, defined in at least two case parts, the case being arranged to at least partially house said adjusting means and, when said at least two case parts are connected to one another, has an outlet orifice for the connecting means,
wherein the outer case comprises a groove extending over a complete periphery of the outer case, said outlet orifice for the connecting means directly opening onto said groove and said groove presenting a depth of groove and a width of groove at least larger than said diameter of said longitudinal connecting means to receive a free part of said connecting means in an adjusted manner.

US Pat. No. 10,507,369

BASKETBALL PERFORMANCE MONITORING SYSTEM

1. A basketball performance monitoring system comprising:a local microprocessor in communication with a remote computational system;
a first sensor coupled to said local microprocessor;
said first sensor coupled to a net of a basketball goal below a rim of the basketball goal;
said first sensor comprising a housing including a single arm extendable inside said net, said local microprocessor being within said housing wherein said first sensor is configured to sense an angular orientation based on the force of gravity responsive to a basketball passing over said arm;
a second sensor coupled to said housing, said second sensor configured to measure an attempted goal; and
a fourth sensor configured as a rim diameter sensor.

US Pat. No. 10,507,365

GOLF CLUB HEAD

Taylor Made Golf Company,...

1. A golf club head comprising:a body having a bottom portion, a top portion, a front portion, a back portion, a heel portion, and a toe portion;
a sole located on the bottom portion of the golf club head;
a face positioned at the front portion of the body, the face being configured to receive an impact;
a top portion silhouette profile located along a perimeter of the top portion, the top portion silhouette profile defining outer bounds of the top portion in an X-direction and Y-direction, the golf club head having a bottom portion volume below the top portion silhouette profile and a top portion volume above the top portion silhouette profile;
a center sole portion extending from the front portion of the body to the back portion of the body, the center sole portion comprising:
a planar surface extending rearwardly along the bottom portion of the golf club head in a generally Y-direction;
a toeward sole surface that slopes upwardly from the planar surface when viewed in an address position;
a first edge extending in a generally Y-direction on a toe side of the planar surface and defining a transition between the planar surface and the toeward sole surface;
a heelward sole surface that slopes upwardly from the planar surface when viewed in the address position; and
a second edge extending in a generally Y-direction on a heel side of the planar surface and defining a transition between the planar surface and the heelward sole surface;
wherein the golf club head has a head origin defined as a position on a face plane at a geometric center of the face, the head origin including an x-axis tangential to the face and generally parallel to a ground plane when the head is in the address position where a positive x-axis extends towards the heel portion, a y-axis extending perpendicular to the x-axis and generally parallel to the ground plane when the head is in the address position where a positive y-axis extends from the face and through a rearward portion of the body, and a z-axis extending perpendicular to the ground plane, to the x-axis and to the y-axis when the head is in the address position where a positive z-axis extends from the head origin and generally upward,
wherein the golf club head has a center of gravity with an x-axis coordinate between about ?2 mm and about 7 mm, a y-axis coordinate between about 15 mm and about 50 mm, and a z-axis coordinate between about ?7 mm and about 2 mm,
wherein a heel-toe dimension of the golf club head is between about 119 mm and about 127 mm,
wherein a top-bottom dimension of the golf club head is between about 63 mm and about 71 mm, and
wherein the bottom portion volume is greater than 60 percent of a total volume of the golf club head.

US Pat. No. 10,507,359

CORE MUSCLE EXERCISE SYSTEM

1. An exercise system enabling a user to perform therewith an exercise of balance, the system comprising:a board having a surface for a user to stand thereon, the board including a plurality of sensors configured to generate measurement data based on movements of the board, the measurement data is received by a computing device that determines a probability of concussion based on a baseline score of an initial ability to balance on the board and a current score of a current ability to balance on the board, the score determined based on the sensor generated measurement data;
a top element having an interface for a user to hold or rest thereon;
a middle element that is telescopically coupled to the top element and the board to adjustably separate the top element and the board from each other between a first position and a second position; and
a bottom element having an interface with the ground, wherein the top element and the bottom element are interconnected and separated from each other with the middle element,
wherein at least one of the board and the bottom element is interchangeably coupled, and wherein the system includes at least one element of instability.

US Pat. No. 10,507,357

FOOT STRETCHING DEVICE

1. A foot stretching device comprising:a base member defining a top face, a bottom face, a first end, and a second end, the bottom face configured to rest on a floor during use;
an upright member configured for positioning against a wall during use, the upright member extending from the first end of the base member in a direction opposite the bottom face of the base member in an assembled state, the upright member and the base member forming a right angle;
wherein the upright member defines a front face opposite a back face, and further wherein in the assembled state a distance between the front face and the second end of the base member is less than a distance between the back face and the second end of the base member, and further wherein the front face defines a receiving zone that is substantially planar and arranged perpendicular to a major plane of the top face of the base member; and
a heelpiece removably attached to the top face of the base member between the first and second ends of the base member.

US Pat. No. 10,507,353

ERGONOMIC STRAP FOR WEIGHT LIFTING AND FITNESS EXERCISES

1. An ergonomic strap for weight lifting and fitness exercises, designed for right and left hands,a right hand design being a mirror image of a left hand design and, comprising, in combination,
a first strap made of a durable and flexible material with one top and one bottom rough surfaces and having a length configured to form a loop encompassing a wrist of a user and to extend beyond; a rigid buckle through which one end portion of said first strap is inserted and then folded back upon itself and stitched;
a second strap made of a soft material and constituting an internal, cushioning component of said ergonomic strap; said second strap having a width commensurate with a width of said first strap and a length for enabling to circumferentially surround and directly contact the wrist; said second strap being superposed on said first strap and stitched together;
a third strap, congruent with said first strap, starting in proximity of said rigid buckle and extending along said first strap; said third strap being superimposed on said first strap, said third strap and said first strap being stitched together at their extremities; said third strap being constituted by a fabric strip with hooks and loops and includes a first, long zone starting in proximity of said rigid buckle and formed by loops, followed by a second, short zone formed by hooks; said third strap, being constituted by said fabric strip with hooks and loops, is used to keep said ergonomic strap secured to the wrist during use, or assembled during storage; and
a fourth strap having a zone commensurate with a width of a palm of a user and being made of a durable and flexible material with rough, opposite/external sides; said fourth strap having one end inserted between and stitched to said first and said third straps; said fourth strap configured to be positioned with respect to said first strap as to be, during a spiral wounding about a weight lifting bar, engageable by a thumb and a juxtapositioned index finger of a user, a position which corresponds to an inclination of ??45 degrees of said fourth strap with respect to said first strap;
a thin, narrow, elastic band, being transversely positioned on said bottom rough surface of said first strap and having ends of the elastic band attached to said first strap, said elastic band being positioned in a zone corresponding to an intersection of said long zone and said short zone; wherein when said ergonomic strap is not in use and already assembled, an end of said fourth strap is inserted through and secured in a space available between said thin, narrow, elastic band and said bottom rough surface.

US Pat. No. 10,507,350

STRAP MADE OF SOFT NON-STRETCHABLE MATERIAL TO STRETCH MUSCLES, TENDONS, JOINTS, CAPSULES, LIGAMENTS OF POSTERIOR AND ANTERIOR LOWER EXTREMITIES

1. An apparatus to enable stretching exercise, comprising:a. a length of non-stretchable cloth material having a first end and a second end, having a first interior channel adjacent the first end and having a second interior channel adjacent the second end;
b. a first arcuate closed loop retaining member having a first opening surrounded by a curved section with integrally formed side sections with a straight base section integrally formed with and retained between the side sections, the straight base section retained within the first interior channel;
c. a portion of the length of non-stretchable cloth material folded back on itself and inserted through the first opening of the first retaining member to create a first cloth retaining member opening with a size of an opening of the first cloth retaining member opening adjustable based on the amount of the length of non-stretchable cloth extending through the first opening of the first retaining member;
d. a second arcuate closed loop retaining member having a second opening surrounded by a curved section with integrally formed side sections with a straight base section integrally formed with and retained between the side sections, the straight base section retained within the second interior channel;
e. a second portion of the length of non-stretchable cloth material folded back on itself and inserted through the second opening of the second retaining member to create a second cloth retaining member opening with a size of an opening of the second cloth retaining member opening adjustable based on the amount of the length of cloth extending through the second opening of the second retaining member;
f. the first retaining member is made out of soft fabric material; and
g. the second retaining member is made out of soft fabric material.

US Pat. No. 10,507,348

APPARATUS AND METHOD FOR UPRIGHT DRUMMING AND EXERCISING

1. A percussion instrument for upright drumming and aerobic and strength training exercise comprising:a. a thumper including: a sound box or drum having upright sides, a base, a resonant top, and an interior in which a striking mechanism is situated; an activity platform located above said sound box and of sufficient dimension and strength for a human to perform exercise actions including: standing, jumping, walking, running, bouncing, and dancing in place; said platform including an upper side and an underside, an actuator being attached to the underside for actuating said striking mechanism,
b. a resilient material for securing and supporting said activity platform above the resonant top of said thumper whereby said platform and attached actuator travel vertically, said resilient material compressing and expanding in direct relation to an amount of force exerted atop said platform,
c. a hole in the resonant top of said thumper to allow said actuator access to said striking mechanism,
d. an upright frame holding a plurality of drums; wherein said upright frame is situated vertically in front of said thumper and is positioned and shaped in such a way that while a user is standing or in motion above said thumper, said plurality of drums are within comfortable striking distance of a user holding percussion mallets or sticks,
e. wherein said upright frame is adjustable whereby said plurality of drums can be adjusted to optimal positions for muscular development when played.

US Pat. No. 10,507,346

IMAGING SYSTEM FOR FIRE FIGHTING TRAINING

LION GROUP, INC., Dayton...

1. A system comprising an imaging device including:a first image capture device configured to detect longwave infrared electromagnetic radiation;
a second image capture device configured to detect near infrared electromagnetic radiation, wherein the first image capture device includes an aperture that is separate and apart from an aperture of the second image capture device;
a display configured to display a visible representation of the detected infrared longwave electromagnetic radiation and the detected near infrared electromagnetic radiation; and
an imaging device controller operatively coupled to the first image capture device and to the second image capture device, wherein the imaging device controller is configured to create a composite image for display on said display, wherein said composite image is based upon an output of said first image capture device and said second image capture device, and wherein the imaging device is configured for use with a display device that is configured to display an image with visible light and an image with near infrared electromagnetic radiation.

US Pat. No. 10,507,345

FUEL CELL DEVICES FOR FIRE PREVENTION ON-BOARD AIRCRAFT

Zodiac Aerotechnics, Pla...

1. An inerting system for an aircraft or other passenger transportation vehicle, comprising:(a) a fuel cell system;
(b) a source of inert gas comprising an oxygen depleted air output of the fuel cell system;
(c) a compartment located on-board the vehicle;
(d) a conduit configured to convey inert gas from the source of inert gas to the compartment to reduce a risk of fire ignition in the compartment or to facilitate extinguishing of fire within the compartment and
(e) a one-way valve coupled with the compartment and configured to release inert gas from the compartment without permitting other gas to enter the compartment through the one-way valve,wherein the compartment houses one or more of:the fuel cell system,at least one electronic component,electronics that control, operate, or are powered by a fuel cell system, or any combination thereof,avionics electronics or electronics for navigation,one or more batteries,one or more electrical cables,at least one electrical panel,an electrical panel for managing power consumption of in-flight entertainment services, for managing galley functions, or for managing functions not directly associated with the galley,or any combination of the foregoing,a heat exchanger associated with the compartment and configured to transfer heat away from the compartment,a controller;
one or more processors in communication with the controller; and
memory including instructions that, when executed by the one or more processors, cause the one or more processors to:
in response to information received from a sensor indicating that conditions in the compartment are indicative of fire or imminent ignition therein, cause the heat exchanger to activate so as to transfer heat away from the compartment.

US Pat. No. 10,507,344

ADVANCED MISTING DELIVERY SYSTEM, METHODS, AND MATERIALS

Mark Steven Baldino, Lor...

1. An advanced adjustable density misting delivery system (AMDS) for detecting and neutralizing a fire, the AMDS comprising:a bladder containing a fire suppressant material;
a pump operatively connected to the bladder via a tube;
a nozzle operatively connected to the pump and the bladder via the tube;
a controller electrically connected to the pump;
a sensor in communication with the controller, the sensor being configured to detect a parameter that indicates the presence of the fire; and
a power supply configured to provide power to the controller and the pump,
wherein the controller is configured to transition the pump from a deactivated state to an activated state when the sensor detects the parameter, such that in the deactivated state the pump does not operate, and in the activated state the pump pumps the fire suppressant from the bladder, through the tube at a pressure of between about 50 psi and about 100 psi, and out the nozzle.

US Pat. No. 10,507,343

LOW PRESSURE DROP ACOUSTIC SUPPRESSOR NOZZLE FOR FIRE PROTECTION INERT GAS DISCHARGE SYSTEM

Tyco Fire Products LP, L...

1. A fire suppression nozzle assembly, comprising:a nozzle comprising,
a first tube having an inner surface and an outer surface, the inner surface of the first tube defining an axially extending passageway, the passageway including an inlet at an axial end of the passageway, a plurality of primary outlets disposed through a sidewall of the first tube, the primary outlets having a combined first flow area;
a second tube circumscribing the first tube, an inner surface of the second tube and the outer surface of the first tube defining a chamber, the plurality of primary outlets providing fluid communication between the passageway and the chamber, a sidewall of the second tube having a first set of radially facing secondary outlets axially offset from the primary outlets in a first direction and a second set of radially facing secondary outlets axially offset from the primary outlets in a second direction opposite the first direction, the first and second sets of radially facing secondary outlets having a combined second flow area greater than the combined first flow area;
an inner annular disc circumscribing the second tube between the first and second sets of radially facing secondary outlets and having sound absorbing material facing the first and second sets of radially facing secondary outlets; and
at least one of:
a first outer annular disc disposed on an opposite side of the first set of radially facing secondary outlets than the inner annular disc, the first outer annular disc having sound absorbing material disposed on a side facing the first set of radially facing secondary outlets; and
a second outer annular disc disposed on an opposite side of the second set of radially facing secondary outlets than the inner annular disc, the second outer annular disc having sound absorbing material disposed on a side facing the second set of radially facing secondary outlets.

US Pat. No. 10,507,338

PARTICLE BEAM RADIOTHERAPY SYSTEM

Canon Medical Systems Cor...

1. A particle beam radiotherapy system comprising:a gantry configured to apply particle beams to a subject;
an ultrasonic diagnostic apparatus configured to scan the subject with ultrasonic waves via an ultrasonic probe, and acquire an ultrasonic image concerning a radiotherapy target region of the subject;
processing circuitry configured to
specify a first planned point of a Bragg peak in the ultrasonic image, which anatomically coincides approximately with a second planned point of the Bragg peak determined using a radiotherapy planning apparatus, the first planned point and the second planned point being positioned so as to be included in the radiotherapy target region, and
estimate a sighting point of the Bragg peak of a particle beam applied by the gantry based on information concerning a body surface position of the subject and an actual range of the particle beam applied by the gantry; and
a display configured to display the ultrasonic image so as to indicate the first planned point and the sighting point.

US Pat. No. 10,507,332

SYSTEM AND METHOD FOR SENSING AND DETECTION IN AN EXTRA-CARDIOVASCULAR IMPLANTABLE CARDIOVERTER DEFIBRILLATOR

Medtronic, Inc., Minneap...

1. A device comprising:a sensing circuit comprising:
a first sensing channel configured to receive a first cardiac electrical signal via a first electrode vector coupled to the device and to sense a first plurality of R-waves in response to crossings of a first R-wave sensing threshold by the first cardiac electrical signal, and
a second sensing channel configured to receive a second cardiac electrical signal via a second electrode vector coupled to the device different than the first electrode vector;
a therapy delivery circuit configured to deliver an anti-tachyarrhythmia therapy via electrodes coupled to the device;
a memory; and
a control circuit coupled to the sensing circuit and the memory and configured to:
store a time segment of the second cardiac electrical signal in the memory in response to each one of the first plurality of R-waves sensed by the first sensing channel;
determine a first plurality of intervals between successive ones of the first plurality of R-waves sensed by the first sensing channel;
determine at least a first predetermined number of the first plurality of intervals are less than a tachyarrhythmia detection interval;
in response to at least a first predetermined number of the first plurality of intervals being less than the tachyarrhythmia detection interval, analyze at least a portion of the time segment of the second cardiac electrical signal corresponding to a most recent one of the R-waves sensed by the first sensing channel to confirm the most recent one of the R-waves;
determine the most recent one of the R-waves is not confirmed based on the analyzing of at least the portion of the corresponding time segment;
update an unconfirmed beat count in response to the most recent one of the R-waves not being confirmed based on the analyzing of at least the portion of the corresponding time segment;
determining a second predetermined number of the first plurality of intervals are less than the tachyarrhythmia detection interval;
in response to a second predetermined number of the first plurality of intervals being less than the tachyarrhythmia detection interval, compare the unconfirmed beat count to a rejection threshold;
determine the unconfirmed beat count is less than the rejection threshold;
detect a tachyarrhythmia episode in response to the second predetermined number of the first plurality of intervals being less than the tachyarrhythmia detection interval and the unconfirmed beat count being less than the rejection threshold, and
control the therapy delivery circuit to deliver the anti-tachyarrhythmia therapy in response to detecting the tachyarrhythmia episode.

US Pat. No. 10,507,331

WEARABLE CARDIAC DEFIBRILLATOR SYSTEM CONTROLLING CONDUCTIVE FLUID DEPLOYMENT

WEST AFFUM HOLDINGS CORP....

1. A wearable defibrillator system, comprising:a support structure configured to be worn by a patient;
an energy storage module configured to store a charge;
two electrodes coupled with the support structure and configured to be applied to two respective patient locations of the patient;
a reservoir coupled to the support structure and configured to store a fluid;
a fluid deploying mechanism configured to cause at least some of the fluid to be released from the reservoir and be deployed near at least one of the patient locations, so as to cause an impedance between the two electrodes to be decreased; and
an impedance measurement circuit configured to sense the decreased impedance, and
in which the stored charge is delivered to the patient via the electrodes responsive to a timeout threshold lapsing since at least some of the fluid has been caused to be released, or responsive to the sensed impedance meeting a discharge condition prior to the timeout threshold lapsing, the discharge condition being distinct from the timeout threshold lapsing, the stored charge thus being delivered to the patient responsive to the earlier of:
i) the timeout threshold lapsing, and
ii) the sensed impedance meeting the discharge condition prior to the timeout threshold lapsing.

US Pat. No. 10,507,326

METHOD AND APPARATUS FOR MULTIMODAL ELECTRICAL MODULATION OF PAIN

Stimgenics, LLC, Bloomin...

1. A method for managing pain in a subject comprising:A) lowering a threshold for depolarization of nerve fibers in the subject with a first oscillating electromagnetic field for a first duration of time; and
B) simultaneously modulating glial cell activity in the subject with a second oscillating electromagnetic field during a second duration of time not identical to the first duration of time,
wherein the first oscillating electromagnetic field is provided by an electrical signal having a current amplitude set to a value corresponding to a percentage of a Priming Perception Threshold (PPT) of the subject, and
wherein the second oscillating electromagnetic field is provided by an electrical signal having a current amplitude set to a value corresponding to a percentage of the paresthesia threshold (PT) of the subject.

US Pat. No. 10,507,325

DEVICES AND METHODS FOR NON-INVASIVE CAPACITIVE ELECTRICAL STIMULATION AND THEIR USE FOR VAGUS NERVE STIMULATION ON THE NECK OF A PATIENT

ElectroCore, Inc., Bosto...

7. An apparatus for modulating a vagus nerve within a body of a patient, the apparatus comprising:a source of energy that generates a single signal comprising an electrical impulse;
an electrode coupled to the source of energy;
an interface coupled to the electrode; and
wherein the source of energy delivers the electrical impulse, based on the single signal, from the electrode through the interface and the outer skin surface to the vagus nerve, as the interface contacts an outer skin surface of a neck of the patient, and thereby modulates the vagus nerve, wherein the electrical impulse comprises bursts of pulses with a silent intra-burst interval between each of the bursts based on the single signal, wherein each of the bursts has a frequency of about 5 Hz to about 100 Hz and each of the pulses has a duration from about 50 microseconds to about 1000 microseconds.

US Pat. No. 10,507,323

MEDICAL TOOL EMPLOYING A WARNING MECHANISM NOTIFYING THAT A ROTATIONAL LIMIT HAS BEEN REACHED

PACESETTER, INC., Sylmar...

1. A medical tool comprising a handle including:a housing;
a torque portion operably coupled to the housing and rotatable relative to the housing, the torque portion including a shaft including an outer circumferential surface and a helical thread portion radially outwardly extending from the outer circumferential surface of the shaft;
a shuttle displaceable along the shaft via threaded interaction with the helical thread portion; and
a warning mechanism interacting with the shuttle that provides a tactile indication when the torque portion has rotated a number of rotations, wherein the shaft includes a first end and a second end opposite the first end, the shaft being capable of infinite rotation in a first direction without causing further displacement of the shuttle along the shaft toward the first end when the shuttle is at a first location near the first end, but rotation of the shaft in a second direction opposite the first direction when the shuttle is at the first location causes the shuttle to displace along the shaft towards the second end.

US Pat. No. 10,507,322

MEDICAL LEAD WITH PERFORMED BIAS

RESPICARDIA, INC., Minne...

1. An implantable medical electrical lead comprising:a. a lead body having a preformed helical bias with a coil diameter; and
b. at least one electrode disposed on a distal portion of the lead body and having a length parallel to the lead body portion on which it is disposed;
c. wherein a ratio of the coil diameter to the length of the at least one electrode is greater than or equal to 4:1.

US Pat. No. 10,507,321

MULTILAYER STRUCTURE AND METHOD OF MANUFACTURING A MULTILAYER STRUCTURE

Medtronic Bakken Research...

1. A medical device system configured to at least one of deliver electrical stimulation to a patient or sense electrical activity of the patient, the system comprising:a thin film including:
at least one electrode,
at least one electrical contact,
at least one electrically conductive track extending between the at least one electrode and the at least one electrical contact,
a first polymer layer;
a second polymer layer, wherein, at a portion of the thin film between the at least one electrode and the at least one electrical contact, the first polymer layer and second polymer layer surround the at least one electrically conductive track; and
at least one discrete ceramic member located between the first and second polymer layers at the portion of the thin film between the at least one electrode and the at least one electrical contact, wherein the at least one discrete ceramic member does not surround the at least one conductive track at the portion of the thin film between the at least one electrode and the at least one electrical contact, wherein the first polymer layer and second polymer layer surround the at least one discrete ceramic member at the portion of the thin film between the at least one electrode and the at least one electrical contact, wherein the at least one discrete ceramic member is in direct contact with the first polymer layer and the second polymer layer, and wherein the at least one discrete ceramic member is configured to increase adhesion between the first polymer layer and second polymer layer.

US Pat. No. 10,507,319

MULTIPLE FLUID DELIVERY SYSTEM WITH MULTI-USE DISPOSABLE SET AND FEATURES THEREOF

BAYER HEALTHCARE LLC, Wh...

1. A multi-use disposable set (MUDS) comprising:a plurality of syringes, each syringe having a proximal end and a distal end spaced apart from the proximal end along a longitudinal axis, a filling port and a discharge outlet at the distal end of each of the plurality of syringes, and a plunger reciprocally movable within a syringe interior of each of the plurality of syringes between the proximal end and the distal end;
a manifold in selectable fluid communication with the discharge outlet of each of the plurality of syringes;
at least one rotatable valve in fluid communication with the distal end of at least one of the plurality of syringes, wherein the at least one rotatable valve comprises a valve head with a slot recessed into the valve head, wherein the slot has a lip at one end of the slot which limits an orientation of a blade of a coupling mechanism of a fluid injector to a single self-aligned orientation, wherein the at least one rotatable valve is rotatably operable between a filling position for filling the syringe interior of the at least one of the plurality of syringes through the filling port and a delivery position for delivering fluid from the syringe interior of the at least one of the plurality of syringes to the manifold through the discharge outlet; and
at least one connection port in fluid communication with the manifold when the at least one rotatable valve is in the delivery position,
wherein the filling port is in fluid isolation from the syringe interior when the at least one rotatable valve is in the delivery position.

US Pat. No. 10,507,316

IMPLANTABLE FLUID ROUTER

RENISHAW (IRELAND) LIMITE...

1. An implantable fluid router comprising:at least one inlet;
at least one outlet; and
at least one filter chamber connecting the inlet to the outlet, the filter chamber comprising a hydrophilic filter membrane and a gas permeable membrane and being configured to separate liquid and gas from a fluid by (i) passing liquid in the fluid received from the inlet through the hydrophilic filter membrane to the outlet, and (ii) passing gas in the fluid received from the inlet through the gas permeable membrane in order to vent the gas from the filter chamber.

US Pat. No. 10,507,314

SKIN RESURFACING DEVICE, CONTROLLING APPARATUS AND CONTROLLING METHOD FOR SKIN RESURFACING DEVICE

1. A controlling apparatus for a skin resurfacing device performing a surgical procedure on a human skin with a surgical needle, comprising:a controller;
a voltage regulator configured to regulate a voltage supplied to the skin resurfacing device from a power supply according to a control of the controller; and
a starting switch configured to turn on/off a supply of power between the voltage regulator and the skin resurfacing device,
wherein the skin resurfacing device has a preset operating voltage and a preset jump start voltage that is higher than the preset operating voltage, wherein the skin resurfacing device has a jump start mode for starting the skin resurfacing device at the preset jump start voltage, and wherein the controller is adapted to control the voltage regulator so as to output the preset jump start voltage to the skin resurfacing device when the starting switch is turned on during the jump start mode.

US Pat. No. 10,507,310

DILATION APPARATUS WITH MALLEABLE FEATURE AND APPARATUS TO BEND MALLEABLE FEATURE

Acclarent, Inc., Irvine,...

1. An apparatus, comprising:(a) a ram die including a bend channel, wherein the bend channel defines a first surface shaped to engage a portion of a guide member of an instrument configured to access a paranasal sinus, the portion having a cross-sectional shape, wherein the bend channel defines a bend shape; and
(b) a pressure die including a pressure channel, wherein the pressure channel defines a second surface shaped to engage the portion of the guide member;
wherein the ram die and the pressure die are configured to be moved toward and urged against each other in a press direction during a bending operation, wherein the first surface of the ram die and the second surface of the pressure die are configured to cooperate together to maintain the cross-sectional shape during the bending operation; and
wherein the pressure die includes an elastically deformable material configured to deform when the ram die advances into the pressure die during the bending operation.

US Pat. No. 10,507,307

GUIDEWIRE FOR CATHETER INSERTION

Horizon Patents, LLC, Fa...

1. A guidewire for insertion into a needle during a medical procedure, the guidewire comprising:a patient-side portion having a first diameter less than an inner diameter of the needle;
a doctor-side portion having a second diameter less than the inner diameter of the needle; and
an intermediary portion, interposed between the patient-side portion and the doctor-side portion, having a diameter greater than the inner diameter of the needle and greater than the first diameter of the patient-side portion such that the intermediary portion does not advance into the needle during the medical procedure when a medical professional pushes axially on the doctor-side portion.

US Pat. No. 10,507,305

SHEATH

Board of Regents of the U...

1. A system configured to receive an interventional tool, the system comprising:a shunt member portion positionable through a perforation in a side wall of an anatomical vessel of a patient, the shunt member portion including:
a distal opening configured to reside in the anatomical vessel, and
a member that resides external to the anatomical vessel and external to the patient;
a sheath tube portion mated to the external member of the shunt member portion, the sheath tube portion including:
a proximal end opposite from the shunt member portion, and
a tube wall retainable in a curved configuration in which a proximal portion of the sheath tube portion is transverse to the shunt member portion, the proximal end of the sheath tube portion configured to receive the interventional tool; and
a location of increased thickness that prevents migration of the sheath tube portion into the patient, the location of increased thickness located between a portion of the shunt member portion residing internal to the patient and the sheath tube portion;
wherein an internal access path defined through the sheath tube portion, the shunt member portion, and the anatomical vessel is configured to movably receive an interventional tool while the sheath tube portion resides entirely external to the patient and the shunt member portion resides partially internal to the patient and partially external to the patient; and
a clasp device configured to retain the sheath tube portion in the curved configuration.

US Pat. No. 10,507,304

CATHETER DEVICES, KITS AND METHODS

VASCULAR BARCELONA DEVICE...

1. A catheter device configured to provide access to a hollow organ through a puncture made in a skin of a patient comprising:a body having a proximal end, a distal end and a non-cylindrical external shape and a flexible insertion tube having a proximal end and a distal end, the body including one or more external flat surfaces located between the proximal and distal ends of the body wherein:
the body comprises:
an internal elongated channel that extends along an entire length of the body between the proximal end and the distal end of the body, wherein the internal elongated channel is configured to receive a removable elongated needle, and
only first and second cutting edges extending rearwardly from the distal end of the body, the first and second cutting edges being located on opposite sides of the body and configured to act together to elongate the puncture when advanced into the puncture,
the flexible insertion tube is fixedly attached to the distal end of the body and comprises:
a tubular elongated passage aligned with the internal elongated channel of the body forming a lumen having a length.

US Pat. No. 10,507,303

MEDICAL DEVICE INCLUDING A VARIABLE TORQUE ASSEMBLY FOR DEVICE DEFLECTION

St. Jude Medical, Cardiol...

1. An assembly for use in deflecting a portion of a medical device, the assembly comprising:a first rotatable member having a constant first outer diameter and a first pull wire coupled thereto;
a second rotatable member having a constant second outer diameter smaller than the first outer diameter and a second pull wire coupled thereto,
wherein the second rotatable member is coupled to the first rotatable member such that a center point of the second rotatable member is radially offset from a center point of the first rotatable member;
wherein the first and second rotatable members are configured such that rotation of the first rotatable member via the first pull wire causes rotation of the second rotatable member and second pull wire resulting in deflection of a distal end of the medical device, and
wherein the first pull wire is configured to wrap around an outer surface of the first rotatable member and wherein the second null wire is configured to wrap around an outer surface of the second rotatable member.

US Pat. No. 10,507,300

ULTRA RAPID CYCLE PORTABLE OXYGEN CONCENTRATOR

SEPARATION DESIGN GROUP I...

1. A portable oxygen concentrator, comprising:a passageway for compressed fresh air;
a conserver;
an exhaust port; and
at least one moisture control unit comprising a barrier material positioned between said passageway and said conserver, between said passageway and said exhaust port, or between said passageway and both said conserver and said exhaust port, wherein said moisture control unit functions to remove moisture from compressed air, to provide moisture to dry product gas, and to sequester moisture upon shutdown.

US Pat. No. 10,507,296

SYSTEM AND METHOD FOR TEACHING, PRACTICING AND PERFORMING EFFECTIVE RESCUE BREATHING

Nihon Kohden Corporation,...

1. A system comprising:a first sensor configured to measure one of a ventilatory volume, a concentration of gas, a respiratory rate and a respiratory pressure;
a second sensor configured to measure a pressure associated with a mask adapted to be attached to a human patient or a mannequin;
a processor configured to analyze a measurement value of the first sensor and a measurement value of the second sensor; and
an output unit connected to the processor, the output unit configured to output, based on a result of the analysis of the processor:
a condition of the mask adapted to be attached to the human patient or the mannequin; and
a condition of the human patient or the mannequin,
wherein the output unit includes a display unit configured to display an image in which an element representing the condition of the mask is superimposed onto an element representing the condition of the human patient or the mannequin.

US Pat. No. 10,507,295

NASAL DRUG DELIVERY DEVICE

Impel Neuropharma, Inc., ...

1. A device for delivery of a compound to an olfactory region of a nasal cavity, the device comprising:an actuator body comprising a vertical portion and an angled portion, the vertical portion comprising a contoured surface to accommodate a facial component of a user's face and configured to house a pressurized propellant container containing propellant and a first portion of a connection channel, the first portion of the connection channel configured to be in communication with the propellant container, the angled portion comprising an additional contoured surface to accommodate an additional component of the user's face and configured to house a second portion of the connection channel;
a diffuser in communication with the second portion of the connection channel;
a drug chamber in communication with the diffuser, the drug chamber configured to hold the compound;
a nozzle in communication with the drug chamber, wherein propellant released from the propellant container is configured to travel through the connection channel, contact the diffuser, and propel the compound out the nozzle forming a plume.

US Pat. No. 10,507,291

AUTOINJECTOR WITH AUDIBLE INDICATION OF COMPLETED DELIVERY

Becton Dickinson France, ...

1. A device for automatic injection of a product into an injection site, the device comprising:a housing having a proximal end and a distal end;
a resilient flexible portion at the distal end of the housing projecting inwardly in a non-deflected position, the resilient flexible portion transitionable between the non-deflected position and a deflected position;
a piston rod movably disposed within the housing;
an intermediate part fixed to a first portion of the piston rod;
a first spring configured to displace the piston rod distally, the first spring located between the proximal end of the housing and the intermediate part; and
a second spring configured to displace the piston rod distally, the second spring located between the distal end of the housing and the intermediate part,
wherein as the intermediate part is moved axially towards the distal end of the housing, the intermediate part deflects the resilient flexible portion radially outward to the deflected position, and once the intermediate part is advanced beyond the distal end of the housing, the resilient flexible portion returns to the non-deflected position.

US Pat. No. 10,507,290

DRUG INJECTION DEVICE WITH RESETTABLE MECHANISM ALLOWING PISTON ROD RETRACTION UPON DRUG CARTRIDGE CHANGE

Sanofi, Paris (FR)

1. A drug delivery device for selecting and dispensing a number of user variable doses of a medicament, the drug delivery device comprising:a housing;
a dose setting element rotatable relative to the housing during dose setting and dose dispensing;
a drive member coupled to the dose setting element via a clutch;
a piston rod coupled to the housing and to the drive member;
a cartridge holder removably attached to the housing and a reset element, which is permanently rotationally constrained to the housing and rotationally constrained to the drive member during dose setting; and
at least one spring acting on the reset element,
wherein if the cartridge holder is detached from the housing, the reset element is axially moved relative to the housing into a position in which the drive member is allowed to rotate relative to the housing, and
wherein the drive member is axially movable relative to the housing between a dose setting position and a dose dispensing position, wherein in the dose setting position, if the cartridge holder is attached to the housing, the drive member is rotationally constrained to the housing via the reset element, and wherein in the dose dispensing position, if the cartridge holder is attached to the housing, the drive member is rotatable relative to the reset element and the housing.

US Pat. No. 10,507,287

NEEDLELESS DRUG DELIVERY SYSTEM

1. A needleless drug delivery system comprising:an upper housing including: a pressure side wall provided to form a side surface of the upper housing with an end wall closing one end of the pressure side wall; and a transmissive lens provided at the end wall;
a lower housing including: a drug side wall provided to form a side surface of the lower housing; and a discharge nozzle provided by extending from the drug side wall and provided with a discharge hole, wherein the lower housing is connected with or extends from the upper housing; and
a separation membrane of elastic material provided between the upper housing and the lower housing to separate the upper housing and the lower housing,
wherein a space of the upper housing having the transmissive lens is hermetically filled with a pressure-generating fluid, and
the separation membrane includes:
a flat-shape membrane;
an edge reinforcing portion protruding along an edge of the flat-shape membrane;
a center reinforcing portion protruding from a center of the flat-shape membrane; and
a plurality of connection reinforcing portions formed on the flat-shape membrane each protruding in a shape that connects any one point of the edge reinforcing portion and the center reinforcing portion,
wherein the separation membrane is disposed between a drug solution and the pressure-generation fluid, and
wherein the edge reinforcing portion, the center reinforcing portion, and the plurality of connection reinforcing portions are formed on the flat-shape membrane to increase a thickness of the separation membrane partially.

US Pat. No. 10,507,286

CONTAINER FOR MIXING AND DISPENSING TWO COMPONENTS

3M Innovative Properties ...

1. A container, comprising:a body having a longitudinal axis, a first end with a first aperture, a second end including a second aperture opposite the first end, and a bypass disposed between the first and the second end;
wherein the bypass has a length L;
a first plug slidably disposed in the body proximate the first end;
a second plug slidably disposed in the body between the first plug and the second end;
wherein the first plug and the second plug define opposite ends of a first compartment disposed in the body between them;
wherein a second compartment is disposed in the body between the second plug and the second end;
wherein the second plug includes:
a top surface facing the first plug;
a bottom surface facing the second end;
a side wall extending between the top surface and the bottom surface, the side wall comprising a circumferential first seal having a first edge proximate the top surface and a circumferential second seal having a second edge proximate the bottom surface; and
a plurality of spaced-apart primary conduits extending through the second plug, each one of the plurality of spaced-apart primary conduits extends from a respective first opening in the side wall to a respective second opening in the bottom surface;
wherein each respective first opening is disposed between the circumferential first seal and the circumferential second seal
wherein at least one of the plurality of spaced-apart primary conduits directs liquid flow out of its respective second opening along a line that is not parallel to the longitudinal axis;
wherein a distance D extends longitudinally from the first edge to the second edge;
wherein a distance E extends longitudinally from the first edge to the separate first openings that are nearest the first edge;
wherein D?L and E

US Pat. No. 10,507,280

MEDICAL INSTRUMENT HOUSING CONTAINER

TERUMO KABUSHIKI KAISHA, ...

1. A medical instrument housing container comprising:a container body including:
a substantially rectangular base,
a peripheral wall having a lower end that is contiguous to a perimeter of the base and extending upward, and
a peripheral edge portion that comprises a plurality of peripheral edges, that is contiguous to an upper end of the peripheral wall, and that extends outwardly,
wherein the substantially rectangular base, the peripheral wall, and the peripheral edge portion are molded from resin, and the container body has an opening surrounded by the peripheral edge portion;
one or more medical instruments held in the container body; and
a protection film that is adhered or heat-sealed to the peripheral edge portion for covering and sealing the opening,
wherein the medical instrument housing container is a medical instrument housing container that has been subjected to sterilization,
wherein each of the plurality of peripheral edges of the peripheral edge portion is curved inwardly, and
wherein the protection film comprises a plurality of outer peripheral edges, each of the plurality of outer peripheral edges of the protective film being curved inwardly along a respective one of the plurality of peripheral edges of the peripheral edge portion.

US Pat. No. 10,507,279

CONTROLLING AN APPARATUS FOR FLUID TRANSFER TO AND/OR FROM A SUBJECT

Gambro Lundia AB, Lund (...

1. An apparatus for extracorporeal blood treatment, comprising:an extracorporeal blood circuit and a connection system configured to connect the extracorporeal blood circuit to the vascular system of a patient, the extracorporeal blood circuit comprising a blood processing device;
at least one pressure sensor configured to sense pressure pulses from a physiological pulse generator in the patient;
at least one pumping device; and
a control system configured to switch between a pre-treatment mode and a blood treatment mode, the control system configured in the blood treatment mode to operate the at least one pumping device to pump blood from the vascular system via the connection system through the blood processing device and back to the vascular system via the connection system, the control system comprising:
a sensor signal input device to obtain measurement data from the at least one pressure sensor configured to sense pressure pulses from a physiological pulse generator in the patient, wherein the measurement data comprises a measurement signal from the at least one pressure sensor; and
a signal processor connected to the sensor signal input device and being configured to, in the pre-treatment mode and post-priming prior to blood treatment, process the measurement data to detect connection of the extracorporeal blood circuit to the vascular system of the patient, wherein the connection is configured to be detected by the control system identifying a characteristic change in the measurement data indicating the connection of the extracorporeal blood circuit to the vascular system of the patient, and, upon such identification of the characteristic change, the control system is configured to take a dedicated action to control operation of the apparatus, the dedicated action comprising enabling the apparatus to enter into the blood treatment mode by operating the at least one pumping device upon identification of the characteristic change in the measurement signal.

US Pat. No. 10,507,278

FLUIDIC DEVICES, METHODS, AND SYSTEMS

Boston Scientific Scimed,...

1. A system comprising:a tubular member with a plurality of lumens extending longitudinally therethrough including a working lumen, a delivery lumen, and a removal lumen;
a filtration device, wherein the filtration device includes at least three filters connected by a fluid conduit;
at least one sensor operable to detect one or more parameters of a fluid;
a delivery module coupled to a fluid reservoir and the delivery lumen;
a removal module coupled to the removal lumen and the filtration device;
a controller; and
a valve coupled to the fluid reservoir, the delivery module, and the filtration device,
wherein the fluid reservoir is coupled to the filtration device so as to define at least one circulation loop to circulate a fluid when the tubular member is placed in a body cavity, and wherein the valve is operable with the controller to direct the fluid from the fluid reservoir back into the filtration device in response to the one or more parameters to form a second circulation loop.

US Pat. No. 10,507,277

BLOOD TREATMENT CASSETTE WITH FILM VALVE AND ELASTIC SPACER AS WELL AS BLOOD TREATMENT APPARATUS

Fresenius Medical Care De...

1. A blood treatment cassette having a cassette body comprising a hard part and a film, wherein the film is connected to the hard part and at least partially covers the hard part,wherein the hard part comprises a valve base that cooperates with a section of the film adjacent the valve base to form a valve, wherein the valve is configured to be moved from a first open position in which the valve base and the section of the film adjacent the valve base do not touch each other to a second position in which the valve base and the section of the film adjacent the valve base touch each other when a force is applied to the section of the film adjacent the valve base,
wherein the blood treatment cassette comprises a spring element connected to the hard part, the spring element comprising at least two humps defining at least one groove or recess therebetween, the spring element being configured such that each of the at least two humps contacts and applies force to the section of the film adjacent the valve base when the valve is in the first open position.

US Pat. No. 10,507,276

MEDICAL FLUID CASSETTES AND RELATED SYSTEMS AND METHODS

Fresenius Medical Care Ho...

1. A medical fluid delivery method, comprising:drawing medical fluid into a fluid pump chamber defined between a membrane and a rigid base of a medical fluid cassette by applying an outward force to an inner surface of a portion of the membrane overlying the fluid pump chamber in an absence of an outward force on an outer surface of the portion of the membrane overlying the fluid pump chamber, wherein the outward force is applied to the membrane by a member disposed in the fluid pump chamber.

US Pat. No. 10,507,274

FLOW THROUGH HEATER

Watlow Electric Manufactu...

1. An electrical heating device for medical equipment, the electrical heating device comprising:a conducting body that is electrically conductive and that forms a channel therethrough for fluid travel;
a base dielectric layer disposed on the conducting body;
a heater surrounding the base dielectric layer and the conducting body;
a top dielectric layer disposed on the heater; and
a protection housing that is preformed and that defines a cavity to receive the top dielectric layer and the heater in the cavity, the base dielectric layer and the top dielectric layer jointly enclosing the heater such that
no portion of the heater is exposed from the base dielectric layer and the top dielectric layer, wherein the protection housing defines side pieces that are in direct contact with the conducting body.

US Pat. No. 10,507,273

METHOD OF FILLING A CONTAINER

FRESENIUS MEDICAL CARE DE...

1. A method of filling a container that contains a concentrate, with the concentrate being provided so as to form a liquid concentrate or a part of a liquid concentrate on solution of the concentrate in, or dilution of the concentrate with, a liquid, the liquid concentrate or the part of a liquid concentrate being suitable for preparing a dialysis solution, and with the filling of the container taking place via a balance chamber system of a dialyzer which has a plurality of chambers from which the liquid is conveyed into the container in a form of repeating cycles, said method comprising:prior to a blood treatment with the dialyzer, measuring a time development of the pressure of the liquid being conveyed from one of the plurality of chambers into the container during a cycle of the filling of the container, the time development of the pressure of the liquid corresponding to a magnitude of pressure pulses generated during an expulsion phase of the liquid; and
at least one of emitting an alarm signal, and stopping the filling of the container, if a measured maximum pressure in a cycle does not reach or does not exceed a limit value.

US Pat. No. 10,507,272

WEARABLE VAD CONTROLLER WITH RESERVE BATTERY

WorldHeart, Inc., Miami ...

1. A method of providing a reserve power source for a ventricular assist device, the method comprising:powering the ventricular assist device with a primary power source, the primary power source including at least one from the group consisting of an external battery and AC mains;
monitoring power provided to the ventricular assist device by the primary power source; and
powering the ventricular assist device with a reserve power source disposed within a controller housing when the monitored power is inadequate to run the ventricular assist device, the ventricular assist device being disposed subcutaneously within a patient, the controller housing being disposed externally of the patient and including a first port for connecting to external battery of the primary power source and a second port for connecting to the AC mains of the primary power source, and the ventricular assist device and the controller housing being connected by a percutaneous cable.

US Pat. No. 10,507,271

FULLY IMPLANTABLE DIRECT MYOCARDIUM ASSIST DEVICE

CorInnova Incorporated, ...

1. An implantable cardiac compression device comprising:an inflatable cardiac compression device comprising a resilient inner panel in contact with a heart periphery comprising one or more membranes contoured to provide curvatures generally in the shape of the heart to affect the end-diastolic heart volume, an inflatable outer panel comprising a plurality of inflatable membranes positioned completely around the resilient inner panel to inflate to affect the end-systolic heart volume completely around the heart periphery, and a fluid connection in communication with the inflatable outer panel for inflation and deflation;
an expandable fluid reservoir in communication with the fluid connection and is adapted to be positioned adjacent the pericardium and configured to house a fluid when displaced from the inflatable cardiac compression jacket; and
a fluid driver operably connected to the inflatable cardiac compression jacket and to the expandable fluid reservoir, wherein the fluid driver is configured to fill the cardiac compression jacket with the fluid at least partially removed from the expandable fluid reservoir during systolic ejection by the heart and is further configured to fill the expandable fluid reservoir with fluid at least partially removed from the cardiac compression jacket during diastolic filling of the heart.

US Pat. No. 10,507,270

SURGICAL APPARATUS, SYSTEM AND METHOD

1. An apparatus for use in combination with a surgical sponge assembly and a trocar including a cannula having an interior wall, the surgical sponge assembly including a suction tube coupled to a sponge head, the apparatus comprising:a body configured to insert within the cannula and including a proximal end, a distal end, a first lumen and a second lumen that join one another to form a cavity defined by an annular wall, a longitudinal axis, an interior wall that extends from the proximal end of the body to the cavity, a first exterior wall that extends around a first portion of the circumference of the apparatus, a second exterior wall that extends around a second portion of the circumference of the apparatus, and a gap formed between the first exterior wall and the second exterior wall extending parallel to the longitudinal axis at least a length of the cavity,
wherein the first lumen and the second lumen are separated from one another by the interior wall included in the body,
wherein, with the body inserted within the cannula, the annular wall defining the cavity includes at least portion of each of the interior wall included in the cannula, the first exterior wall and the second exterior wall, respectively,
wherein the first lumen is sized and configured to allow an axial movement of the suction tube within the first lumen, the cavity configured to store at least a portion of the sponge head,
wherein the apparatus is configured to allow the surgical sponge assembly to be moved from a retracted position in which at least a portion of the sponge head is stored within the cavity and an extended position in which at least some of the portion of the sponge head stored within the cavity in the retracted position is located beyond the distal end of the body, and
wherein the apparatus is configured to be inserted within the cannula with the sponge head stored in the cavity in the retracted position.

US Pat. No. 10,507,268

ELECTROSPUN MATERIAL COVERED MEDICAL APPLIANCES AND METHODS OF MANUFACTURE

MERIT MEDICAL SYSTEMS, IN...

1. A medical appliance, comprising:a first layer of electrospun polytetrafluoroethylene (PTFE), having an average percent porosity between about 30% and about 80%, the first layer of electrospun PTFE disposed such that it defines an inside surface of the medical appliance;
a second layer of electrospun PTFE, having an average percent porosity between about 0% and about 50%, the second layer of electrospun PTFE disposed such that it defines an outside surface of the medical appliance; and
tie layer of fluorinated ethylene propylene (FEP) disposed between the first layer of electrospun PTFE and the second layer of electrospun PTFE, wherein the tie layer is impervious to tissue or fluid migration into or through the tie layer.

US Pat. No. 10,507,267

HIGHLY HYDROPHOBIC ANTIFOULING COATINGS FOR IMPLANTABLE MEDICAL DEVICES

INTERNATIONAL BUSINESS MA...

1. A method for forming an organocatalyzed polythioether coating, the method comprising:providing a first solution comprising a bis-silylated dithiol and a fluoroarene, the bis-silylated dithiol comprising 2,2,11,11-tetramethyl-3,10-dithia-2,11-disiladodecane;
providing a second solution comprising an organocatalyst;
mixing the first solution and the second solution to form a mixed solution;
applying the mixed solution to a substrate; and
curing the substrate.

US Pat. No. 10,507,264

CROSS-LINKED HYDROGELS AND METHOD OF MAKING THE SAME

REGELTEC, INC., Baltimor...

1. A method of repairing or supplementing the nucleus of an intervertebral disc in a patient in need thereof, comprising:(a) filling a syringe with a hydrogel comprising:
about 12 wt. % to about 22 wt. % of polyvinyl alcohol;
about 0.12 wt. percent to about 0.22 wt. % of polyvinylpyrrolidone;
about 12 wt. % to about 22 wt. % non-functionalized polyethylene glycol having a Mw of about 500 Da to about 2,000 Da; and
a solvent,
wherein the hydrogel does not contain a chemically cross-linked polymer;
(b) heating the hydrogel of step (a) to about 65° C.;
(c) connecting a 15 gauge or smaller needle to the syringe;
(d) inserting the needle into the nucleus of an intervertebral disc in need of repair or supplement; and
(e) injecting a therapeutically effective amount of the hydrogel, wherein the hydrogel does not contain a chemically cross-linked polymer, into the nucleus of an intervertebral disc to provide a tissue implant.

US Pat. No. 10,507,262

BIOCOMPATIBLE HYDROGEL TREATMENTS FOR RETINAL DETACHMENT

C.P. MEDICAL CORPORATION,...

1. A method of delivering a therapeutic to an eye, the method comprising:administering to the eye a therapeutic agent and a formulation comprising:
(a) multi-ARM nucleophilic polyol monomers having more than two nucleophilic arms, wherein each nucleophilic arm comprises a polyethyleneglycol chain and terminates in a nucleophilic amino group, wherein the nucleophilic arms of the multi-ARM nucleophilic polyol monomers are selected from

 and wherein n is 1-200;
(b) multi-ARM electrophilic polyol monomers having more than two electrophilic arms, wherein each electrophilic arm comprises a polyethyleneglycol chain and terminates in an electrophilic succinimidyl group, wherein the electrophilic arms of the multi-ARM electrophilic polyol monomers are selected from
wherein m is 2 or 3 and wherein n is 1-200; and(c) a viscosity enhancer selected from acacia, agar, bentonite, carbomers, carboxymethylcellulose calcium, ceratonia, cetostearyl alcohol, colloidal silicon dioxide, cyclomethicone, glyceryl behenate, guar gum, hectorite, hydrogenated vegetable oil type I, hydroxypropyl starch, hydroxypropylmethylcellulose, hydroxyethylcellulose, magnesium aluminum silicate, maltodextrin, polycarbophil, polydextrose, poly(methylvinyl ether/maleic anhydride), polyvinyl acetate phthalate, potassium chloride, propylene glycol alginate, saponite, sodium chloride, stearyl alcohol, sucrose, sulfobutylether ?-cyclodextrin, tragacanth, and mixtures thereof.

US Pat. No. 10,507,260

BIOMEDICAL FOAMS

Stryker European Holdings...

1. A nasal packing comprising a phase-separated polymer including an amorphous segment and a crystalline segment, said polymer having the formula:—[R-Q1[—R?—Z1—[R?—Z2—R?—Z3]p—R?—Z4]q—R?-Q2]-n  (I),
wherein:
the amorphous segment comprises R, and at least one R comprises the reaction product of a polyethylene glycol initiator having a number average molecular weight of 600 to 2000 g/mol, lactide, and ?-caprolactone, such that said at least one R comprises a first polyester segment based on lactide and ?-caprolactone, a central hydrophilic segment based on polyethylene glycol, and a second polyester segment based on lactide and ?-caprolactone, wherein said at least one R comprises:
polyethylene glycol in a content of 10-60 wt. %, and
lactide and ?-caprolactone in a content of 5-60 wt. %,
R? and R? are independently C2-C8 alkylene,
Z1-Z4 are each urethane,
Q1 and Q2 are each urethane,
n is an integer from 5-500,
p and q are both 1,
wherein said nasal packing has a complete fragmentation time ranging from 1 to 10 days.

US Pat. No. 10,507,259

FLEXIBLE ABSORBENT PAD

FIRST QUALITY RETAIL SERV...

1. An absorbent pad comprising:a liquid permeable topsheet;
an absorbent core disposed below the topsheet and comprising superabsorbent polymer particles and having a plurality of ridges of a first thickness separated by one or more flexure hinges of a second thickness less than the first thickness to permit flexing of the absorbent core about the one or more flexure hinges, the absorbent core having an entire length that extends from a first longitudinal end and a second longitudinal end of the absorbent core, both the ridges and the flexure hinges extending lengthwise across the entire length of the absorbent core in a continuous manner with the ridges interleaved with the one or more flexure hinges; and
a backsheet disposed below the absorbent core and comprising a liquid impermeable layer;
wherein the absorbent core is bonded to the backsheet with a first adhesive that is applied as a pattern of adhesive to at least one of the plurality of ridges on the absorbent core before the backsheet is bonded to the absorbent core, and the pattern of adhesive is not applied to the one or more flexure hinges, to keep the one or more flexure hinges substantially devoid of adhesive.

US Pat. No. 10,507,258

COMPACT, MOBILE, MODULAR, INTEGRATED DIFFUSER APPARATUS AND METHOD

1. An apparatus comprising: a housing; a drive system capable of drawing in and pressurizing a stream of air; a first sleeve enclosed completely within the housing and being sized, shaped, and positioned to enclose the drive system, thereby defining an annulus capable of passing the stream along an outer surface of the drive system; a reservoir capable of containing a liquid to be atomized by the stream; an atomizer capable of connecting in fluid communication with the reservoir, to receive a portion of the liquid therefrom, and in fluid communication with the drive system, to receive at least a portion of the stream therefrom, thereby spraying the stream of air carrying droplets formed from the portion of the liquid; a second sleeve enclosed completely within the housing and capable of enclosing the reservoir and atomizer, together selectively insertable into and removable from the second sleeve without tools; the drive system and atomizer capable of connecting in a fluid-sealing relation to feed the stream from the drive system into the atomizer when the atomizer is fitted into the second sleeve; wherein the annulus operates as a cooling channel cooling the drive system by passing the stream around the drive system upon entry into the apparatus.

US Pat. No. 10,507,256

AUTOMATED DECONTAMINATION OF COMPLEX AREAS

The Boeing Company, Chic...

1. A method for decontaminating an area, the method comprising:deploying a mobile decontamination unit in the area,
the mobile decontamination unit comprising an aerosol dispersing nozzle and an aerosol directing fan;
determining aerosol dispersing parameters for the mobile decontamination unit based on area characteristics;
dispersing a decontaminant within the area using the aerosol dispersing nozzle and in accordance with the aerosol dispersing parameters,
the decontaminant being dispersed in an aerosol form comprising a decontaminant droplets;
directing the decontaminant droplets to surfaces in the area using aerosol directing fan and in accordance with the aerosol dispersing parameters; and
changing orientation of the aerosol directing fan relative to the area, comprising changing orientation of a head portion of the mobile decontamination unit relative to a base portion of the mobile decontamination unit, wherein the head portion comprises the aerosol dispersing nozzle and the aerosol directing fan.

US Pat. No. 10,507,255

SYSTEMS AND METHODS FOR DISINFECTING A REMOTE CONTROL USING ULTRAVIOLET LIGHT

DISH TECHNOLOGIES L.L.C.,...

1. A method of determining when to activate an ultraviolet light emitter, the method comprising:receiving information from a temperature sensor;
determining that a current time is during one of: a first time period in which a first threshold temperature is used and a second time period in which a second threshold temperature is used, the first threshold temperature being greater than the second threshold temperature;
determining whether the information indicates a location of a person is not near the ultraviolet light emitter; and
in response to determining that the location of the person is not near the ultraviolet light emitter, activating the ultraviolet light emitter,
wherein the determining of whether the information indicates the location of the person is not near the ultraviolet light emitter includes:
determining whether a temperature indicated by the information from the temperature sensor is above the first threshold temperature, in response to determining that the current time is during the first time period;
based on determining that the temperature indicated by the information from the temperature sensor is above the first threshold temperature, determining that the location of the person is not near the ultraviolet light emitter and activating the ultraviolet light emitter;
determining whether the temperature indicated by the information from the temperature sensor is below the second threshold temperature, in response to determining that the current time is during the second time period; and
based on determining that the temperature indicated by the information from the temperature sensor is below the second threshold temperature, determining that the location of the person is not near the ultraviolet light emitter and activating the ultraviolet light emitter.

US Pat. No. 10,507,251

ANTI-HUMAN MUC1 ANTIBODY FAB FRAGMENT

Astellas Pharma Inc., To...

1. A conjugate comprising one or more labeling moiety and an anti-human MUC1 antibody Fab fragment, wherein the labeling moiety is (i) a fluorescent dye and a linker or (ii) a fluorescent dye, and wherein the anti-human MUC1 antibody Fab fragment is selected from the group consisting of the following (a) and (b):(a) an anti-human MUC I antibody Fab fragment comprising a heavy chain fragment comprising a heavy chain variable region consisting of the amino acid sequence represented by SEQ ID NO: 8 or SEQ ID NO: 10 and a light chain comprising a light chain variable region consisting of the amino acid sequence represented by SEQ ID NO: 12; and
(b) an anti-human MUC1 antibody Fab fragment comprising a heavy chain fragment comprising a heavy chain variable region derived from a heavy chain variable region consisting of the amino acid sequence represented by SEQ ID NO: 8 or SEQ ID NO: 10 by the modification of glutamine at amino acid position 1 of SEQ ID NO: 8 or SEQ ID NO: 10 into pyroglutamic acid, and a light chain comprising a light chain variable region consisting of the amino acid sequence represented by SEQ ID NO: 12.

US Pat. No. 10,507,248

HYDROPHOBIC CORE CARRIER COMPOSITIONS FOR DELIVERY OF THERAPEUTIC AGENTS, METHODS OF MAKING AND USING THE SAME

PharmaIN Corporation, Bo...

1. A composition, consisting of:(i) a polymeric carrier;
(ii) a plurality of first hydrophobic groups, wherein each first hydrophobic group of the plurality of first hydrophobic groups is covalently linked to the carrier, is capable of binding a load molecule, comprises an alkyl group of 8-36 carbons, and has a molecular weight between 150 to 1000 Daltons independent of the carrier weight;
(iii) a plurality of first protective side chains, wherein each first protective side chain is covalently linked to the carrier and has a molecular weight between about 400 and 20,000 Daltons independent of the carrier weight, and wherein each first protective side chain is polyethylene glycol, polypropylene glycol, a co-polymer of polyethylene glycol and polypropylene glycol, or an alkoxy derivative thereof;
(iv) optionally a plurality of second hydrophobic groups, wherein each second hydrophobic group is covalently linked at a first end to the carrier and is linked at a second end to a second protective side chain having a molecular weight between 400 and 20,000 Daltons independent of the carrier weight,
wherein each second hydrophobic group is capable of binding a load molecule, has a molecular weight of less than 1,000 Daltons independent of the carrier weight, and
wherein each second protective side chain is polyethylene glycol, polypropylene glycol, a co-polymer of polyethylene glycol and polypropylene glycol, or an alkoxy derivative thereof; and
(v) a load molecule dissociably linked to the hydrophobic groups; and
(vi) a pharmaceutically acceptable excipient;
wherein a weight ratio of total protective side chains to total hydrophobic groups is more than 17:1 and the composition is soluble in aqueous buffer.

US Pat. No. 10,507,237

ATTENUATED AFRICAN SWINE FEVER VIRUS VACCINE

The Pirbright Institute, ...

1. An attenuated African Swine Fever (ASF) virus capable of inducing an immune response, which lacks a functional version of the DP148R gene.

US Pat. No. 10,507,228

METHODS AND COMPOSITIONS RELATED TO KRAS INHIBITORS

H. Lee Moffitt Cancer Cen...

1. A compound having the following structure:
wherein X1 and X2 are amino acid residues bonded together.

US Pat. No. 10,507,226

N-AMINO PEPTIDE BETA-SHEET MIMICS FOR THE TREATMENT OF ALZHEIMER'S DISEASE

University of South Flori...

1. A compound of formula (I),or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5, and R6 are each independently selected from hydrogen or —NH2, and wherein at least one of R1, R2, R3, R4, R5, and R6 is —NH2.

US Pat. No. 10,507,215

COMPOUNDS FOR THE TREATMENT OF ADDICTION

Amygdala Neurosciences, I...

1. A compound of Formula (II):wherein:R1 is hydrogen, —CH2OH, —CH2OP(O)(OR20)(OR21), or optionally substituted C1-6 alkyl;
R2 is hydrogen, halo, optionally substituted lower C1-6 alkyl, or optionally substituted cycloalkyl;
each of R3, R4, R5, R6, R9, R10, R11, R12 and R13 is independently hydrogen, hydroxyl, —OP(O)(OR20)(OR21), —CH2OH, —CH2OP(O)(OR20)(OR21), optionally substituted alkyl, optionally substituted alkylene, optionally substituted alkynyl, optionally substituted alkoxy, optionally substituted cycloalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted heteroaryl, optionally substituted heteroaralkyl, optionally substituted heterocyclyl, aminocarbonyl, acyl, acylamino, —O—(C1 to C6-alkyl)-O—(C1 to C6-alkyl), cyano, halo, SO2NR24R25; or —NR24R25;
R7 is hydrogen or optionally substituted C1-6 alkyl;
each of R20 and R21 is independently Na+, Li+, K+, hydrogen, C1-6 alkyl; or R20 and R21 can be combined to represent a single divalent cation Zn2+, Ca2+, or Mg2+; and
each of R24 and R25 is independently chosen from hydrogen or C1-6 alkyl or when combined together with the nitrogen to which they are attached form a heterocycle; or
a pharmaceutically acceptable salt, ester, single stereoisomer, mixture of stereoisomers, or tautomer thereof.

US Pat. No. 10,507,214

PHARMACEUTICAL COMPOSITION CONTAINING CELECOXIB

Druggability Technologies...

1. A pharmaceutical composition comprising:a Celecoxib complex, said complex comprising:
5-40 weight % Celecoxib,
40-80 weight % of a copolymer of vinylpirrolidone and vinyl acetate, and
5-30 weight % sodium lauryl sulfate; and
crystalline Celecoxib;wherein the pharmaceutical composition is prepared by blending the Celecoxib complex and the crystalline Celecoxib.

US Pat. No. 10,507,213

METHOD FOR TREATING CANCER USING A SELENOUREA-COORDINATED GOLD(I)-CARBENE COMPLEX

King Fahd University of P...

1. A method for treating a proliferative disease, disorder or condition in a subject, comprising:administering to a subject in need thereof a composition comprising [Au(Ipr)(Seu)][anion] (1), wherein Ipr is 1,3-bis(2,6-di-isopropylphenyl)imidazol-2-ylidene, and Seu is selenourea, as described by Formula (3):

wherein the proliferative disease, disorder, or condition is breast cancer, colon cancer or lung cancer.

US Pat. No. 10,507,212

METHOD FOR USE OF HOMOPIPERAZINIUM COMPOUNDS IN THE TREATMENT OF CANCER

1. A method for treating cancer comprising administering to a patient in need thereof an effective amount of a compound having the formula:
wherein R1 and R2 are independently alkyl of 1 to 6 carbon atoms or cycloalkyl of 3 to 6 carbon atoms,
Xa is CH or N,
Ya is hydrogen or independently selected from halogen, cyano, hydroxyl, alkyl of 1 to 6 carbon atoms, alkoxy of 1 to 6 carbon atoms, heteroaryl of 6 members and aryl,
n is an integer from 1 to 5,
J is a counter ion; and
wherein said cancer is a carcinoma or a blastoma, wherein said carcinoma is selected from the group of lung cancer and colon cancer, and wherein said blastoma is a neuroblastoma.

US Pat. No. 10,507,209

QUINAZOLINE DERIVATIVES SUBSTITUTED BY ANILINE, PREPARATION METHOD AND USE THEREOF

XUANZHU PHARMA CO, LTD., ...

1. A method of treating ovarian cancer, colorectal cancer, mammary cancer, glioma, non-small cell lung cancer, bladder carcinoma, gastric cancer, adenocarcinoma of the esophagus, esophageal squamous cell cancer, head and neck cancer, or pancreatic cancer, which comprises a step of administering a compound represented by a general formula (I), a pharmaceutically acceptable salt thereof or a stereoisomer thereof to a mammal in need thereof,
wherein
R1 is selected from the group consisting of:

R2 is selected from the group consisting of hydrogen, methyl that is unsubstituted or substituted by 1-2 Q2 substituent(s) and ethyl that is unsubstituted or substituted by 1-2 Q2 substituent(s),
Q2 is selected from the group consisting of:
a di(C1-4alkyl)amino group, piperidinyl, piperazinyl, morpholinyl, pyrrolidinyl, furyl, cyclopropyl, cyclopentyl, pyrrolyl, pyridyl, pyrimidinyl, and thiazolyl;
R3 is selected from the group consisting of fluoro and chloro;
R4, R5, and R6 are hydrogen;
L is O; and
n is 2.

US Pat. No. 10,507,206

ORAL FORMULATIONS AND LIPOPHILIC SALTS OF METHYLNALTREXONE

Wyeth, LLC, Madison, NJ ...

1. A pharmaceutical composition for oral administration comprising a solid dosage of a methylnaltrexone salt of formula (I)
wherein A? comprises lauryl sulfate, wherein the composition is a tablet, wherein the composition comprises from about 7% to about 75% methylnaltrexone cation and dodecyl sulfate anion, based upon the total weight of the composition.

US Pat. No. 10,507,202

NAPROXEN-BASED NON-STEROIDAL ANTI-INFLAMMATORY DRUG WITH LOW GASTRIC TOXICITY

Kazan Federal University,...

1. A non-steroidal anti-inflammatory drug based on naproxen formula (I):having anti-inflammatory, analgesic and antipyretic activity, as well as reduced acute toxicity and gastric toxicity.

US Pat. No. 10,507,201

USE OF RING-FUSED BICYCLIC PYRIDYL DERIVATIVES AS FGFR4 INHIBITORS

NOVARTIS AG, Basel (CH)

1. A method of treating a solid malignancy comprising a cancer characterized by positive FGFR4 and FGF19 expression or by positive FGFR4 and KLB expression or positive FGFR4, FGF19 and KLB expression, comprising administering a compound of formula (I), or a pharmaceutically acceptable salt thereof:
wherein
V is selected from CH2, O, and CH(OH);
W is selected from CH2, CH2CH2, and bond;
X is C(RX) or N;
Y is C(RY) or N;
Z is CH or N;
wherein when X is N, Y and Z are not N;
wherein when Y is N, X and Z are not N;
wherein when Z is N, X and Y are not N;
RX is selected from hydrogen, halogen, haloC1-C3alkyl, cyano, C1-C6alkyl, and hydroxyC1-C6alkyl;
RY is selected from hydrogen, halogen, C1-C3alkyl, C1-C6alkoxy, hydroxyC1-C3alkoxy, NRY1RY2, cyano, C1-C3alkoxyC1-C3alkoxy, C1-C3alkoxy-haloC1-C3alkoxy, di(C1-C3alkyl)aminoC1-C6alkoxy, O—(CH2)0-1—RY3, CRY6RY7, S—C1-C3alkyl, and haloC1-C6alkoxy optionally substituted with hydroxy;
or
RX and RY together with the ring to which they are attached form a bicyclic aromatic ring system optionally further comprising one or two heteroatoms selected from N, O, and S, which ring system is optionally substituted with C1-C3alkyl;
RY1 is hydrogen and
RY2 is C1-C6alkyl; hydroxyC1-C6alkyl; haloC1-C6alkyl optionally substituted with hydroxy; C1-C4alkoxyC1-C6alkyl; haloC1-C3alkoxyC1-C6alkyl; (CH2)0-1—RY4; di(C1-C3alkyl)aminoC1-C6alkyl substituted with hydroxy; bicyclo[2.2.1]heptanyl substituted with hydroxyC1-C3alkyl; phenyl substituted with S(O)2—CH(CH3)2; bicycloC5-C8alkyl; or C2-C3alkylsulfonic acid;
or
RY1 and RY2 together with the N atom to which they are attached form a saturated or unsaturated non-aromatic 6-membered heterocyclic ring which may contain an O atom, which ring may be substituted once or twice by RY5;
RY3 is selected from quinuclidinyl, a 4-, 5- or 6-membered saturated heterocyclic ring comprising at least one heteroatom selected from N, O and S, and a 5- or 6-membered aromatic heterocyclic ring, which saturated or aromatic heterocyclic ring is optionally substituted with C1-C3alkyl and/or oxo;
RY4 is a 4-, 5- or 6-membered saturated heterocyclic ring comprising at least one heteroatom selected from N, O, and S, which ring is optionally substituted with C1-C3alkyl;
RY5 is independently selected from C1-C3alkyl, hydroxy, and di(C1-C3alkyl)aminoC1-C3alkyl,
or
two RY5 attached at the same carbon atom form together with the carbon atom to which they are attached a 5-membered saturated heterocyclic ring comprising at least one heteroatom selected from N, O and S, which ring is substituted once or more than once with C1-C3alkyl;
RY6 and RY7 together with the carbon atom to which they are attached form a 6-membered saturated or unsaturated non-aromatic heterocyclic ring comprising one heteroatom selected from N, O and S;
R1 is selected from hydrogen; halogen; C1-C3alkyl; haloC1-C3alkyl; hydroxyC1-C3alkyl; C3-C6cycloalkyl; CH2NR2R3; CH(CH3)NR2R3; C1-C3alkoxyC1-C3alkyl; CH2CO2H; C(O)H; C1-C3alkoxy; and a 5- or 6-membered saturated heterocyclic or aromatic heterocyclic ring comprising at least one heteroatom selected from N, O and S, which ring is optionally substituted once or more than once with a group independently selected from C1-C3alkyl, haloC1-C3alkyl, oxetanyl and oxo;
R2 is selected from C1-C3alkyl, and di(C1-C3alkyl)aminoC1-C3alkyl;
R3 is selected from C1-C3alkyl, C(O)C1-C3alkyl, C(O)—CH2—OH, C(O)—CH2—O—CH3, C(O)—CH2—N(CH3)2, and S(O)2CH3;
or
R2 and R3 together with the N atom to which they are attached form a saturated 5- or 6-membered ring optionally comprising one additional heteroatom selected from N, N-oxide, O and S, which ring may be substituted once or more than once with R4;
R4 is independently selected from C1-C3alkyl, di(C1-C3alkyl)amino, C(O)CH3, and hydroxy;
or
two R4 attached at the same carbon atom form together with the carbon atom to which they are attached a 4-, 5- or 6-membered non-aromatic heterocyclic ring comprising at least one heteroatom selected from N, O and S;
or
two R4 attached at the same ring atom form an oxo group; and
R5 is selected from hydrogen and C1-C3alkyl,
for use in the treatment of the cancer, wherein the cancer is selected from breast cancer, glioblastoma, prostate cancer, rhabdomyosarcoma, gastric cancer, ovarian cancer, lung cancer, colon cancer characterized by positive FGFR4 and KLB expression, or by positive FGFR4 and FGF19 expression, or by positive FGFR4, KLB and FGF19 expression.

US Pat. No. 10,507,192

METHODS FOR TREATING OR PREVENTING FATIGUE USING O-CARBAMOYL-PHENYLALANINOL COMPOUNDS

SK Biopharmaceuticals Co....

1. A method for treating or preventing fatigue which is associated with a disease, disorder or condition selected from the group consisting of depression, cancer, multiple sclerosis, Parkinson's disease, Alzheimer's disease, chronic fatigue syndrome, fibromyalgia, chronic pain, traumatic brain injury, AIDS, and osteoarthritis in a subject, comprising administering to a subject in need thereof, a treatment or prevention effective amount of a compound of Formula I:
or a pharmaceutically acceptable salt, ester, or prodrug thereof, wherein
R is a member selected from the group consisting of hydrogen, lower alkyl of 1 to 8 carbon atoms, halogen selected from F, Cl, Br and I, alkoxy containing 1 to 3 carbon atoms, nitro, hydroxy, trifluoromethyl, and thioalkoxy containing 1 to 3 carbon atoms;
x is an integer of 1 to 3, with the proviso that R may be the same or different when x is 2 or 3;
R1 and R2 can be the same or different from each other and are independently selected from the group consisting of hydrogen, lower alkyl of 1 to 8 carbon atoms, aryl, heteroaryl, arylalkyl, and cycloalkyl of 3 to 7 carbon atoms;
or R1 and R2 can be joined to form a 5 to 7-membered heterocycle substituted with a member selected from the group consisting of hydrogen, alkyl, aryl, and heteroaryl groups, wherein the cyclic compound can comprise 1 to 2 nitrogen atoms and 0 to 1 oxygen atom, wherein the nitrogen atoms are not directly connected with each other or with the oxygen atom.

US Pat. No. 10,507,190

METHOD FOR TREATING HYPERHIDROSIS WITH DEXMECAMYLAMINE

Atacama Therapeutics, Inc...

1. A method of treating hyperhidrosis, the method comprising the administration of a therapeutically effective amount of dexmecamylamine or a pharmaceutically acceptable salt thereof, substantially free of exo-R-mecamylamine, to a subject with hyperhidrosis.

US Pat. No. 10,507,189

ANALGESIC COMPOSITIONS

Vapogenix, Inc., Houston...

1. An uniform composition comprising a halogenated volatile compound and hydroxypropyl cellulose (HPC);wherein the halogenated volatile compound is selected from the group consisting of isoflurane, halothane, enflurane, sevoflurane, desflurane, methoxyflurane, and any mixtures thereof.

US Pat. No. 10,507,184

IMPLANTABLE NALTREXONE TABLETS

RUSAN PHARMA LIMITED, Ka...

1. A naltrexone implantable tablet composition comprising naltrexone in an amount of 500 to 2000 mg, wherein, the composition is devoid of magnesium salts and corticosteroids, to provide a controlled amount of the active over a period of 3 months or more;wherein the implantable tablet composition comprises a granulate of 20 to 100 mg of a biodegradable polyester and the naltrexone.

US Pat. No. 10,507,182

REMOTE LOADING OF SPARINGLY WATER-SOLUBLE DRUGS INTO LIPOSOMES

ZONEONE PHARMA, INC., Sa...

1. A pharmaceutical formulation comprising carfilzomib encapsulated within a liposome, said liposome comprising a lipid membrane defining an internal aqueous compartment comprising said encapsulated carfilzomib, said lipid membrane comprising: (a) sphingomyelin (SM); (b) cholesterol; and (c) PEG-(1,2-distearoyl-sn-glycero-3-phosphoethanolamine) (PEG-DSPE), wherein said formulation is selected from a lyophilized formulation and a formulation in which said liposome is suspended in a pharmaceutically acceptable diluent.

US Pat. No. 10,507,181

METHODS FOR TREATING LUNG DISORDERS

Crititech, Inc., Lawrenc...

1. A method for treating a lung tumor, comprising pulmonary administration to a subject with a lung tumor of an amount effective of a composition comprising taxane particles to treat the lung tumor, wherein the taxane particles comprise at least 95% of the taxane and have a mean particle size (number) of between 0.1 ?m and 5 ?m, wherein the taxane particles have a specific surface area (SSA) of at least 12 m2/g, wherein the taxane particles are present in a suspension comprising the taxane particles and a pharmaceutically acceptable carrier, wherein the suspension is aerosolized for administration, wherein the pulmonary administration comprises nebulization, and wherein the nebulization results in pulmonary delivery to the subject of aerosol droplets of the taxane particles suspension.

US Pat. No. 10,507,180

SMALL VOLUME ORAL TRANSMUCOSAL DOSAGE FORMS CONTAINING SUFENTANIL FOR TREATMENT OF PAIN

AcelRx Pharmaceuticals, I...

1. A dosage form for oral transmucosal administration to a subject, comprising: an analgesic drug, wherein said dosage form is bioadhesive and has a volume of less than 30 microliters or a mass of less than 30 mg.

US Pat. No. 10,507,168

MUSICAL TEETHER

KAR KOI LEUNG, Hong Kong...

9. A teether comprising a body member, a musical unit removably engageable with the body member and a transmitter for transmitting vibrational musical signal from the musical unit to the body member for onward transmission to teeth of the infant, wherein the transmitter is generally elongate in profile with enlarged opposite ends and narrower middle region, and is disposed in a conduit in the body member and is in abutment with the musical unit and the outer portion at the opposite ends, wherein the middle region of the transmitter is not in contact with walls defining the conduit of the teether for facilitating transmission of vibrational musical signal.

US Pat. No. 10,507,167

SMART PILL BOX AND MEDICAL COMPLIANCE MONITORING

Vivint, Inc., Provo, UT ...

1. An apparatus for dispensing medication, comprising:a processor;
memory in electronic communication with the processor, and
instructions stored in the memory and executable by the processor to cause the apparatus to:
receive information of a person from a device carried by an authorized user indicating a proximity of the authorized user to the apparatus;
determine whether the person is attempting to access a compartment of the apparatus casing the medication based at least in part on sensor data;
determine a time period of the received information of the person based at least in part on the person attempting to access the compartment of the apparatus casing the medication;
determine that the time period satisfies a threshold timeframe when the medication is to be taken by the person based at least in part on a behavioral pattern of the person; and
permit the authorized user to dispense the medication after receiving the information and based at least in part on the time period satisfying the threshold timeframe.

US Pat. No. 10,507,166

APPARATUS AND METHOD OF MANUFACTURING MULTI-COLUMN MULTI-MEDICINE ORAL DISSOLVING FILM

C. L. Pharm, Seoul (KR)

7. A method of manufacturing a multi-column multi-medicine oral dissolving film comprising:a lower wrapping sheet feeding step of feeding a lower wrapping sheet coated with the oral dissolving film;
an oral dissolving film coating step of coating the oral solution film separated with a predetermined size by injecting a raw solution of the oral dissolving film on a upper surface of the lower wrapping sheet fed in the lower wrapping sheet feeding step and moved along a plurality of roll routes;
a drying step of drying the oral dissolving film coated in the oral dissolving film coating step by hot air, infrared rays, and dehumidifying methods;
an upper wrapping sheet feeding step of feeding an upper wrapping sheet to an upper portion of the oral dissolving film dried in the drying step;
a sealing step of separately sealing the oral dissolving film by bonding the upper wrapping sheet and the lower wrapping sheet to a periphery of each of the oral dissolving films by a thermocompression bonding method; and
a pouch packaging step of separating the oral dissolving films separately sealed in the sealing step into individual products by slitting and cutting the oral dissolving films,
wherein the oral dissolving film coating step includes a step of performing multi-column coating by using a plurality of nozzles which have a plurality of nozzle holes arranged at a certain interval and are arranged above and below to be supplied with different medicines so that different medicines are coated in multiple columns in a single layer so as to be connected continuously with each other without being overlapped.

US Pat. No. 10,507,165

MULTI CHAMBER FLEXIBLE BAG AND METHODS OF USING SAME

1. A method of preparing a pharmaceutical product in a multiple chamber flexible bag, the method comprising:introducing the pharmaceutical product in a liquid state into a first chamber of the flexible bag through a first port; and
lyophilizing the pharmaceutical product within the first chamber of the flexible bag to provide a lyophilized pharmaceutical product,
wherein the flexible bag has a second chamber and a third chamber,
wherein the first chamber and the second chamber are separated by a first breakable seal,
wherein the third chamber is separated from one of the first and the second chambers by a second breakable seal, and
wherein the pharmaceutical product is a cytotoxic drug.

US Pat. No. 10,507,164

GLASS CONTAINERS WITH IMPROVED STRENGTH AND IMPROVED DAMAGE TOLERANCE

CORNING INCORPORATED, Co...

1. A coated glass container comprising:a borosilicate glass body having a Type 1 chemical durability according to USP 660 (2011), at least a class A2 base resistance or better according to ISO 695, and at least a type HGB2 hydrolytic resistance or better according to ISO 719, the glass body having an interior surface and an exterior surface and a wall extending therebetween, wherein the glass body forms the interior surface of the coated glass container and wherein the coated glass container does not comprise a boron-rich layer on the interior surface of the glass body;
a lubricous coating having a thickness of less than 100 microns positioned on at least a portion of the exterior surface, wherein:
the portion of the exterior surface of the coated glass container with the lubricous coating has a coefficient of friction that is at least 20% less than an uncoated glass container formed from the same glass composition and the coefficient of friction does not increase by more than 30% after undergoing a depyrogenation cycle at a temperature of about 260° C. for 30 minutes and abrasion under a 30 N load;
the lubricous coating can be pyrolized at temperatures less than or equal to 300° C. in a time period of less than or equal to 1 hour;
a horizontal compression strength of the coated glass container is at least 10% greater than an uncoated glass container formed from the same glass composition and the horizontal compression strength is not reduced by more than 20% after undergoing a heat treatment at a temperature of about 260° C. for a period of time of 30 minutes and abrasion under a 30 N load;
the lubricous coating is a polymer; and
a surface region extending over the inner surface and having a persistent surface homogeneity such that the glass body is resistant to delamination such that for a discrete point on the inner surface of the glass body, an extrema of a surface concentration of each constituent component of the glass composition in the surface region at the discrete point is greater than or equal to about 70% and less than or equal to about 130% of the same constituent component in the surface region at any second discrete point on the inner surface of the glass body when the glass body is in an as-formed condition.

US Pat. No. 10,507,163

METHOD OF MANUFACTURING A PTP SHEET FOR PACKAGING A PHARMACEUTICAL DRUG

NIPRO CORPORATION, (JP)

1. A method of manufacturing a PTP sheet for packaging a pharmaceutical drug, comprising:positioning a first flat sheet of fixed thickness between a die and a heating plug, the die having a concavity, the heating plug having an annular-shaped end surface;
contacting a partial region of the first flat sheet with the annular-shaped end surface, the annular-shaped end surface of the heating plug imparting heat to a corresponding annular shape at the partial region;
decompressing a concavity of the die by flowing air from the concavity;
in response to the decompressing sucking a pocket portion of the first flat sheet into the concavity and molding the pocket portion to a shape of the concavity, and
extending length of the heated partial region during said decompressing and sucking, so that wall thickness of the partial region decreases relative to wall thickness of a remaining portion of the pocket portion and a portion of the first sheet surrounding the pocket portion;
wherein the PTP sheet comprises the first flat sheet and a second sheet, the first flat sheet having a surface for facing the second sheet, the first flat sheet having a first portion, a second portion, and a third portion, the first portion and second portion configured for contacting the second sheet;
wherein the third portion is configured during said sucking and extending steps as the pocket portion having sidewalls and a base portion, the pocket portion configured for holding the pharmaceutical drug; and
wherein the partial region forms at least a portion of the sidewalls, the sidewalls having a wall thickness less than the wall thickness of the base portion, the first portion, and the second portion.

US Pat. No. 10,507,162

MASSAGE BATHING MAINTENANCE SYSTEM AND MAINTENANCE METHOD OF THE SAME

DARTPOINT TECH. CO., LTD....

1. A massage bathing maintenance system, which is applied for a massage bathing equipment, comprising:at least one attached device attached to the massage bathing equipment and provided for actuating to the massage bathing equipment;
at least one slave control device, which comprises a control unit and a detection-feedback device, wherein the control unit is configured to generate and transmit at least one actuating message according to at least one actuating-status of the at least one attached device;
a master control device configured to control the at least one slave control device, through a master-slave connection therebetween, for receiving the at least one actuating message, and the master control device comprising a log-collecting unit configured to record the at least one actuating message of the at least one slave control device into a logs table; and
an analyzing unit configured to analyze the at least one actuating message of the logs table to determine the actuating-status of the at least one attached device;
wherein the control unit controls the detection-feedback device in a manner that detects the at least one attached device, generates the at least one actuating message including a result of the detection, and transmits the at least one actuating message to the master control device,
wherein the actuating message contains a physical value or a chemical value,
wherein the master control device generates at least one controlling message to the at least one slave control device according to at least one preset remote detecting and maintaining management process, and the master control device requests the control unit of the at least one slave control device to proceed a detection so that the at least one slave control device generates the at least one actuating message including the detection result,
wherein the detection-feedback device comprises at least one switch unit and at least one sensing unit, the at least one switching unit is controlled by the control unit to turn on or off a power source supplied to the at least one attached device, the at least one sensing unit detects the physical value between the at least one switch unit and the at least one attached device, and transmits the physical value to the control unit, and the control unit treats the physical value as the detection result to generate the at least one actuating message according to the detection result and provides the at least one actuating message to the master control device; or
the detection-feedback device comprises at least one switch unit and at least one sensing unit, the at least one switching unit is controlled by the control unit to turn on or off a power source supplied to the at least one attached device, the at least one sensing unit detects the physical value of the at least one attached device, and transmits the physical value to the control unit, and the control unit treats the physical value as the detection result to generate the at least one actuating message according to the detection result and provides the at least one actuating message to the master control device; or
the detection-feedback device comprises at least one switch unit and at least one sensing unit, the at least one switching unit is controlled by the control unit to turn on or off a power source supplied to the at least one attached device, the at least one sensing unit detects the physical value between the power source supplied to the at least one attached device and the at least one attach device, and transmits the physical value to the control unit, and the control unit treats the physical value as the detection result to generate the at least one actuating message according to the detection result and provides the at least one actuating message to the master control device.

US Pat. No. 10,507,161

BACK PLATES FOR MECHANICAL CPR COMPRESSION

JOLIFE AB, Lund (SE)

1. A back plate (100?) for use with a cardiopulmonary resuscitation (CPR) compression device, comprising:a top surface (102?);
first and second sides (106?, 108?);
third and fourth sides (118?);
first and second static attachment elements (112?), wherein the first static attachment element is configured on the first side to releasably connect to a first leg of the CPR compression device, and the second static attachment element is configured on the second side to releasably connect to a second leg of the CPR compression device;
a bottom surface (104?) comprising a plurality of ribs (116?) that run from the first side to the second side in parallel to the third and fourth sides; and
at least two anti-slip surfaces adhered to the ribs;
wherein the back plate includes a hollow portion between the top and bottom surfaces and the first, second, third, and fourth sides, and wherein the ribs and third and fourth sides provide structural rigidity to the back plate.

US Pat. No. 10,507,160

MASSAGE BAG WITH CONFIGURABLE POSITIONS

Circus Shark Productions,...

1. A massage apparatus, comprising:a sealed bag including a single compartment, wherein the sealed bag comprises one or more pieces of fabric sealed with one or more seams;
one or more massage spheres contained inside the compartment; and
a single configuration strip, wherein the single configuration strip comprises a piece of textile, wherein the single configuration strip is oriented along an exterior portion of a first side of the sealed bag, wherein the single configuration strip has a length approximately equal to a length of the first side of the sealed bag, wherein the single configuration strip is attached to the first side of the sealed bag at a single attachment point located central to the length of the first side of the sealed bag.

US Pat. No. 10,507,159

CUSTOM MASSAGE PROGRAMMING USING TOUCHSCREEN INTERFACE

Ford Global Technologies,...

1. A massage system, comprising: a seat having a first surface;a first massage assembly beneath the first surface and including a first matrix of inflatable bladders;
an interface including a touchscreen displaying an image of the first matrix on the touchscreen and receiving a touch input;
a processor interpreting the touch input as an indication of a desired massage sequence; and
a controller causing the first massage assembly to implement the desired massage sequence,
wherein the touch input is in the form of a continuous, moving touch over an area of the touchscreen on which the image of the first matrix is displayed; and
the processor interprets the touch input as the indication of the desired massage sequence by defining the continuous moving touch as a line over the image of the first matrix and including ones of the bladders contacted or intersected by the line in the massage sequence;
wherein the processor further interprets the touch input as the indication of the desired massage sequence by matching sequence of inflation and deflation of the ones of the bladders included in the massage sequence with a direction of movement of the continuous, moving touch input.

US Pat. No. 10,507,157

INTERFACE FOR CONSTRUCTING TRAJECTORY IN AN ENVIRONMENT AND ENVIRONMENT ASSEMBLY AND TRAJECTORY CONSTUCTION INTERFACE

1. An interface for constructing a trajectory in an environment for a user, the user having, at a given time, a position and direction on the trajectory, wherein the interface comprises:first haptic means for transmitting information to the user;
at least one camera connected to an image recognizing computer program for recognizing the environment;
means for real-time calculation and a memory connected to the first haptic means for transmitting information to the user, and connected to the at least one camera for receiving information therefrom and transmitting instructions thereto;
the at least one camera allowing to indicate in real time, to the user, information about a direction of a future passage gate on the trajectory via the first haptic means for transmitting information to the user;
second haptic means for transmitting information to the user;
means for calculating a distance;
the means for calculating a distance being connected to the means for real-time calculation and memory and allowing to indicate in real time, to the user, distance information to the future passage gate on the trajectory via the second haptic means for transmitting information to the user;the trajectory construction interface further comprising an environment, the trajectory construction interface comprising a mapping of the environment, the environment comprising at least one object, wherein:the means for real time calculation and memory store the mapping;
the trajectory construction interface further comprises means for determining the position of a user and means for determining the actual azimuth of the user;
the first haptic means for transmitting information to the user indicate the direction of the at least one object, the first haptic means for transmitting information to the user being controlled by the means for real-time calculation according to the mapping stored in the memory, to user position information from the means for determining position and/or to user actual azimuth information from the means for determining actual azimuth; and
the second haptic means for transmitting information to the user indicate the distance of the at least one object, the second haptic means being controlled by the means for real-time calculation according to the mapping stored in the memory, to user position information from the means for determining position and/or to user actual azimuth information from the means for determining actual azimuth.

US Pat. No. 10,507,156

LOAD DETECTING DEVICE AND WALK ASSISTING DEVICE

TOYOTA JIDOSHA KABUSHIKI ...

1. A load detecting device comprising:a sole shape portion configured to contour to an entire sole of a user;
a flare portion projecting away from the sole shape portion;
at least one first load sensor disposed within the sole shape portion and configured to detect a load on the sole shape portion;
a second load sensor disposed within the flare portion and outside of the sole shape portion, the second load sensor being configured to detect a load on the flare portion separate from the load on the sole shape portion; and
a load supporting pin projecting into the flare portion and extending towards the second load sensor such that the load supporting pin and the second load sensor are vertically aligned when the load detecting device is in use.

US Pat. No. 10,507,155

TREMOR SUPPRESSION APPARATUS AND METHOD USING SAME

1. A method of suppressing a tremor comprising:a) providing a neuromuscular plasticity apparatus comprising:
i) a rotational drive device that rotates a coupler about a rotational axis and the rotational drive device has a first user interface that moves at a drive amplitude and drive frequency; wherein the first user interface is coupled to the rotational drive device by said coupler; said coupler comprising: a drive end that is connected with the rotational drive device; a user interface end; an offset portion between the drive end and the first user interface that offsets the first user interface from the rotational axis of the rotational drive device to produce an offset radius distance of the first user interface that creates an orbital path of the first user interface when the rotational drive device rotates the coupler; wherein the offset radius distance is no more than 25 mm; and in use, the neuromuscular plasticity apparatus is coupled to said user's limb to produce a forced motion of said user's limb in a direction of the user's tremor;
b) measuring a user's tremor frequency;
c) coupling the first user interface with said user's limb;
d) setting the drive frequency of the rotational drive device to be substantially the same as said user's measured tremor frequency, within 50% of the said user's measured tremor frequency; and
e) moving the first user interface by rotating the coupler about said rotational axis at said drive amplitude of no more than 25 mm and said drive frequency of at least 3 Hz but no more than 30 Hz to drive said user's limb at substantially said user's measured tremor frequency, wherein the drive frequency is within about 50% of said measured tremor frequency.

US Pat. No. 10,507,154

THERAPEUTIC DEVICE FOR POST-OPERATIVE KNEE

1. A method for exercising a joint and a limb of a patient, the method comprising:supporting the limb at an angle with an actuation arm of an exercise device, the actuation arm rotatable about a rotation axis and including a first portion and a second portion, the second portion is movable in a direction perpendicular to the rotation axis; and
restricting movement of the second portion of the actuation arm and a foot plate at a distal end of the second portion in the direction perpendicular to the rotation axis unless force exerted on the foot plate by the patient with their foot against the foot plate exceeds a predetermined force as measured by a foot plate load cell mounted to the foot plate.

US Pat. No. 10,507,153

RELOCATION MODULES AND METHODS FOR SURGICAL FIELD

1. A module for housing unrelated electronic and electromechanical equipment for use during surgery including a waste blood and fluid suction system, the module comprising:a lower section for housing unrelated electronic and electromechanical equipment;
a tower-like upper section located on top of the lower section;
a water-resistant cowling enclosing at least a portion of the lower section and the tower-like upper section; and
one or more bucket-like recesses in or on the cowling of the lower section for mounting one or more fluid suction canisters;
the one or more fluid suction canisters mounted on the one or more bucket-like recesses are operably coupled to a vacuum source controlled from within the module;
wherein the bucket-like recesses for mounting one or more fluid suction canisters also include one or more electronic scales for measuring the combined weight of each fluid suction canister and its blood and fluid contents.

US Pat. No. 10,507,152

ASSISTIVE DEVICE, AND METHOD OF USE

Blue Orchid Care Inc., H...

1. An assistive device comprising:a chassis;a handle assembly pivotally attached to said chassis, said chassis comprising a handle chassis portion for receiving a handle assembly and a platform chassis portion extending from handle chassis portion with a standing platform; wherein said handle assembly includes a pair of oppositely disposed, elongated tubular members, wherein a first end of each of said pair of oppositely disposed, elongated tubular members comprises an arcuate segment, and a primary transverse tubular handlebar grip secured between said first ends;a locking mechanism operable to place said handle assembly into a plurality of positions, and maintain said handle assembly in one of said plurality of positions;
wherein a second end of each of said pair of oppositely disposed, elongated tubular members is coupled to said locking mechanism;
a lever mechanism coupled to said locking mechanism to actuate said locking mechanism; and
wherein said plurality of positions correspond to one of a loading position, an upright position and a storage position.

US Pat. No. 10,507,151

PATIENT SUPPORT APPARATUS WITH SIDE RAIL

Stryker Corporation, Kal...

1. A patient support apparatus comprising:a frame;
a side rail mounted to said frame, said side rail including a side rail body and a pair of arms mounting said side rail body for movement over a full range of motion relative to said frame, said pair of arms having a first pair of pivot connections connected to said side rail body and a second pair of pivot connections for mounting to said frame;
a timing link; and
said first pair of pivot connections engaging said timing link, and each of said first pair of pivot connections and said timing link being located within said outer perimeter of said side rail body over said full range of motion of said side rail body.

US Pat. No. 10,507,150

INTENSIVE USE FURNITURE

Norix Group, Inc., West ...

1. An intensive use bed comprising a molded, non-penetrable outer shell having a generally horizontal top, a bottom, a pair of generally vertical end walls, a generally vertical first side wall, a generally vertical second side wall and a plurality of mounting flanges, each of the generally vertical end walls on the top, the first generally vertical side wall on the top, the first side wall attached to and between the pair of end walls whereby the end walls are in spaced relation and substantially parallel to each other, the second generally vertical side wall on the top, the second side wall attached to and between the pair of end walls, the bottom on the pair of generally vertical end walls, the bottom attached to the first and second side walls whereby the top and bottom are in spaced relation and substantially parallel to each other, each of the plurality of mounting flanges comprising a bolt hole extending through the bottom, one of the plurality of mounting flanges disposed in a first one of the pair of end walls adjacent the bottom, another one of the plurality of mounting flanges disposed in the first side wall adjacent the bottom, a first end support ridge in the first one of the pair of end walls, a first side support ridge disposed in the first side wall, a recessed pocket in the top, a recessed pocket in the bottom.

US Pat. No. 10,507,149

NURSING BED AND CONTROL METHOD THEREOF

BOE TECHNOLOGY GROUP CO.,...

1. A nursing bed, comprising:a bed body, provided with a plurality of combined bed boards, at least one of the plurality of combined bed boards is provided with one or more pressure sensors;
a comparator, connected to the one or more pressure sensors, and configured to compare pressure data transmitted by the one or more pressure sensors with a predetermined pressure value and output a warning signal when the pressure data transmitted by the one or more pressure sensors is greater than or equal to the predetermined pressure value;
a timer, connected to the comparator, and with respect to each of the pressure sensors, configured to start timing when the warning signal is received and output an alarm signal when a preset time is reached;
an alarm device, connected to the timer, and configured to give an alarm after the alarm signal is received,
a plurality of liftable rods, corresponding to the plurality of combined bed boards in a one-to-one correspondence relation, and each of the plurality of liftable rods is fixed at a lower surface of the corresponding combined bed board;
a combined bed board controller, connected to the comparator, and configured to determine the combined bed board corresponding to the warning signal upon receiving the warning signal and generate a moving downward control signal; and
a combined bed board driving motor, connected to the liftable rods and the combined bed board controller, and configured to drive a liftable rod of the combined bed board that corresponds to the warning signal to move downward according to the moving downward control signal.

US Pat. No. 10,507,147

PATIENT SUPPORT

Hill-Rom Services, Inc., ...

1. A patient support comprisinga mattress having a plurality of inflatable bladders including an air loss enclosure having a first opening adjacent a foot end of the air loss enclosure and having a second opening adjacent a head end of the air loss enclosure, the second opening being oblong,
a valve box located within the mattress, and
a control unit spaced from the mattress, wherein inside the control unit a compressor is housed and a blower is housed, the compressor being pneumatically coupled through the valve box to a first inflatable bladder of the plurality of inflatable bladders, the blower being pneumatically coupled through the valve box to the air loss enclosure of the plurality of inflatable bladders.

US Pat. No. 10,507,146

SITTING TO STANDING LIFT CHAIR

1. A sitting to standing lift chair, comprising:a base having a base platform;
a bottom elevated platform, the bottom elevated platform having a bottom surface, a top surface, a front edge, and a rear edge;
an electromechanical chair height adjustment mechanism supporting the bottom elevated platform on the base platform
a seat bottom, the seat bottom having a bottom surface, a top surface, a front edge, and a rear edge;
an electromechanical sitting to standing mechanism supporting the seat bottom on the bottom elevated platform;
a seat back and a seat back hinge rotatably attaching the seat back to the rear edge of the seat bottom, the seat back having a bottom edge, a top edge, a right edge, a left edge, a front surface, and a rear surface;
a first chair height adjustment switch electrically connected to the electromechanical chair height adjustment mechanism for actuating the chair height adjustment mechanism, the first switch having a neutral position, an up position activating the electromechanical chair height adjustment mechanism to raise the bottom elevated platform relative to the base platform, and a down position activating the electromechanical chair height adjustment mechanism to lower the bottom elevated platform relative to the base platform; and
a second sitting to standing switch electrically connected to the electromechanical sitting to standing mechanism for actuating the sitting to standing mechanism, the second switch having a neutral position, an up position actuating the electromechanical sitting to standing mechanism to raise and rotate the seat bottom relative to the elevated platform and to raise the seat back relative to the elevated platform toward a standing position of the sitting to standing lift chair, and a down position actuating the electromechanical sitting to standing mechanism to lower and rotate the seat bottom relative to the elevated platform and to lower the seat back relative to the elevated platform toward a seating position of the sitting to standing lift chair.

US Pat. No. 10,507,145

POWERED PATIENT SUPPORT APPARATUS

Stryker Corporation, Kal...

1. A patient support apparatus comprising:a base having a plurality of wheels;
a patient support deck supported by said base, said patient support deck adapted to support a patient;
a first motor adapted to provide power to a powered wheel, the powered wheel being one of the plurality of wheels;
a second motor adapted to steer a steered wheel, the steered wheel being one of the plurality of wheels;
a sensor adapted to detect a person positioned off-board the patient support apparatus; and
a controller adapted to control a direction and speed of the patient support apparatus using the first and second motors, respectively, such that movement of the patient support apparatus across a floor matches walking movement of the person.

US Pat. No. 10,507,143

METHOD AND APPARATUS FOR PREDICTING EXCRETION BY A DIAPER WEARER

1. A method of predicting excretion by a diaper wearer in a diaper, the method comprising the steps of:a) providing in or on the diaper on the wearer an excretion detector capable of detecting excretion by the diaper wearer and a motion sensor capable of detecting movements of the diaper wearer;
b) continuously detecting with the sensor and at least temporarily recording movements of the diaper wearer;
c) analyzing the detected movements and determining movement patterns therefrom;
d) on detection of excretion by the detector, registering a movement pattern immediately preceding the detection of excretion as a critical movement pattern; and
e) thereafter on detecting of movements matching the critical movement pattern, sending a signal to a user.

US Pat. No. 10,507,140

WOUND CARE METHOD AND SYSTEM WITH ONE OR BOTH OF VACUUM-LIGHT THERAPY AND THERMALLY AUGMENTED OXYGENATION

ThermoTek, Inc., Flower ...

1. A method of treating a wound area, the method comprising:covering the wound area with a therapy pad, the therapy pad comprising:
a first layer;
a second layer operatively coupled to the first layer;
a fiber-optic array disposed between the first layer and the second layer;
a third layer operatively coupled to the first layer, the third layer having a vacuum tube in fluid communication with a vacuum source and a therapeutic fluid tube in fluid communication with a therapeutic fluid source, wherein the third layer provides at least one of vacuum therapy and therapeutic fluid treatment to the wound area;
administering ultra-violet light therapy and vacuum therapy to the wound area through the therapy pad; and
administering oxygenation therapy and thermal therapy to the wound area through the therapy pad.

US Pat. No. 10,507,139

WOUND DRESSING APPARATUS AND METHOD OF USE THEREOF

FIRST CARE PRODUCTS LTD.,...

1. A wound-dressing apparatus, the apparatus comprising:an elongated wrapping element; and
a foldable pad element;
wherein said pad element comprises a first portion attached to a second portion, each portion comprising at least one absorbent layer;
wherein at least part of said first portion is attached to a first surface of said wrapping element such that said at least one absorbent layer faces away from said first surface;
wherein said second portion is configured to have an open position and a closed position, such that when said second portion is in the open position, said at least one absorbent layer faces away from the first surface of said wrapping element;
wherein said second portion is configured to be removed from said first portion, and
wherein said second portion extends beyond said first portion and said first surface of the wrapping element when in said open position.

US Pat. No. 10,507,137

TACTILE INTERFACE SYSTEM

1. A directional information communication system comprising:a first unit configured to be worn at a first ear of a user, the first unit comprising a first tactile output device configured to deliver a tactile output to the first ear, wherein said tactile output to the first ear is operable to produce a tactile sensation at the first ear of the user;
a second unit configured to be worn at a second ear of the user, the second unit comprising a second tactile output device configured to deliver a tactile output to the second ear, wherein said tactile output to the second ear is operable to produce a tactile sensation at the second ear of the user; and
a processor configured to cause tactile output from at least one of the first and second tactile output devices according to directional information received by the directional information communication system such that a direction is operable to be communicated to the user through said tactile sensation at the first ear of the user and said tactile sensation at the second ear of the user, wherein said direction corresponds to said directional information received by the directional information communication system.

US Pat. No. 10,507,135

OPHTHALMIC TREATMENT APPARATUS AND TREATMENT BEAM RADIATING METHOD FOR SAID APPARATUS

LUTRONIC VISION INC., Bu...

1. An ophthalmic treatment apparatus, comprising:a beam generation unit which generates a beam for treatment; and
a beam delivery unit which guides the beam for treatment generated by the beam generation unit to a retina region of an eyeball; and
an imaging unit which generates an image of the retina region of the eyeball in a direction perpendicular to at least one plane of at least one focal spot of the beam for treatment that is guided by the beam delivery unit,
wherein the ophthalmic treatment apparatus controls the beam delivery unit so that a location of the at least one plane of the at least one focal spot to which the beam for treatment is radiated is controlled based on curvature of the retina region of the eyeball photographed by the image unit,
wherein the at least one plane includes a plane of a first focal spot and a plane of a second focal spot which is separated by a distance from the plane of the first focal spot, and the beam delivery unit radiates the beam for treatment to the retina region of the eyeball in a pattern comprising a plurality of focal spots, and
wherein a controller divides the pattern into a reference pattern located on the plane of the first focal spot and a control pattern located on the plane of the second focal spot and controls the beam delivery unit to radiate the first pattern onto the first focal spot and, after terminating radiation of the first pattern, to radiate the second pattern onto the second focal spot,
wherein the plane of the first focal spot forms a tangential plane in an arc of the retina region of the eyeball through which an optical axial line of the beam for treatment penetrates,
wherein the plane of the second focal spot is parallel to the plane of the first focal spot along the optical axial line and connects both ends of an arc formed with a contact point of the retina region interposed between the two sides,
wherein the separation distance between the plane of the first focal spot and the plane of the second focal spot corresponds to the curvature of the retina region of the eyeball,
wherein the ophthalmic treatment apparatus analyzes the image of the retina region of the eyeball transmitted by the image unit and measures the separation distance between the plane of the first focal spot and the plane of the second focal spot, and
wherein the ophthalmic treatment apparatus controls an operation of the beam delivery unit so that the beam for treatment is radiated to the plane of the first focal spot and the plane of the second focal spot based on the separation distance between the plane of the first focal spot and the plane of the second focal spot.

US Pat. No. 10,507,134

SYSTEMS AND METHODS FOR PULSED POSTERIOR VITREOUS DETACHMENT CREATION

Novartis AG, Basel (CH)

1. A method of performing a posterior vitreous detachment, the method comprising:receiving a command from a user of a surgical system to initiate a detachment process;
wherein the surgical system comprises a surgical console and a handpiece fluidly coupled to the surgical console;
wherein the surgical console comprises a fluid reservoir; and
wherein the handpiece comprises a handle portion configured to be grasped by a user and a flexible elongate lumen coupled to a distal end of the handle portion;
forcing a first pulse of fluid from the fluid reservoir through the flexible elongate lumen to a surgical site to separate a vitreous from a retina; and
forcing a second pulse of the fluid from the fluid reservoir through the flexible elongate lumen to the surgical site to further separate the vitreous from the retina, without repositioning the handpiece between the first and second pulses.

US Pat. No. 10,507,130

SHOULDER AND ARM SUPPORT

PMI 20-90, LLC, Lincoln,...

1. A device for supporting and treating a patient's shoulder and arm, comprising:a case configured to be positioned at one side of the patient;
 said case comprising:
(a) an upstanding inner panel having an inner side, an outer side, an upper end, a lower end, a first side and a second side;
(b) said inner side of said upstanding inner panel being curved so as to be capable of conforming to the side of the patient;
(c) an upstanding first side panel having an upper end, a lower end, an inner end, and an outer end;
(d) said inner end of said upstanding first side panel being joined to said first side of said upstanding inner panel;
(e) said outer end of said upstanding first side panel extending downwardly and outwardly from said upper end of said upstanding first side panel to said lower end of said upstanding first side panel;
(f) an upstanding second side panel having an upper end, a lower end, an inner end, and an outer end;
(g) said inner end of said upstanding second side panel being joined to said second side of said upstanding inner panel;
(h) said outer end of said upstanding second side panel extending downwardly and outwardly from said upper end of said upstanding second side panel to said lower end of said upstanding second side panel
(i) a horizontally disposed bottom panel having an inner end, an outer end, a first side and a second side;
(j) said inner end of said horizontally disposed bottom panel being joined to said lower end of said upstanding inner panel;
(k) said first side of said horizontally disposed bottom panel being joined to said lower end of said upstanding first side panel;
(l) said second side of said horizontally disposed bottom panel being joined to said lower end of said upstanding second side panel;
(m) a horizontally disposed upper panel having an inner end, an outer end, a first side, a second side;
(n) said inner end of said horizontally disposed upper panel being joined to said upper end of said upstanding inner panel;
(o) said first side of said horizontally disposed upper panel being joined to said upper end of said upstanding first side panel;
(p) said second side of said horizontally disposed upper panel being joined to said upper end of said upstanding second side panel;
(q) an outer panel having an inner end, an outer end, a first side and a second side;
(r) said inner end of said outer panel being pivotally joined to said outer end of said horizontally disposed upper panel whereby said outer panel is movable between first and second positions;
(s) each of said upstanding inner panel, said upstanding first side panel, said upstanding second side panel, said horizontally disposed bottom panel, said horizontally disposed upper panel and said outer panel having interior and exterior surfaces;
(t) a flexible bellow having an inner end, an outer end, a first side including first and second side portions, and a second side including third and fourth side portions;
(u) said first side portion being joined to said outer end of said upstanding first side panel;
(v) said second side portion being joined to said first side of said outer panel;
(w) said third side portion being joined to said outer end of said upstanding second side panel;
(x) said fourth side portion being joined to said second side of said outer panel;
(y) said upstanding inner panel, said upstanding first side panel, said upstanding second side panel and said horizontally disposed bottom panel defining an interior compartment which is closed by said bellow and said outer panel;
(z) a resilient foam cushion positioned in said interior compartment;
(aa) said resilient foam cushion having an inner end, an outer end, an upper end, a lower end, a first side and a second side;
(bb) an air inflatable bladder positioned in said interior compartment outwardly of said outer end of said resilient foam cushion;
(cc) said air inflatable bladder being configured to be moved between a collapsed position and an inflated position;
(dd) said outer panel is configured to be moved from said first position towards said second position;
(ee) said outer panel having a plurality of arm supports secured to said respective exterior surface;
(ff) a length adjustable shoulder strap having first and second ends;
(gg) said first end of said length adjustable shoulder strap being secured to said upstanding first side panel at said upper end thereof;
(hh) said second end of said length adjustable shoulder strap being secured to said upstanding second side panel at said upper end thereof;
(ii) a length adjustable body strap having first and second ends;
(jj) said first end of said length adjustable body strap being secured to said upstanding first side panel at said lower end thereof; and
(kk) said second end of said length adjustable body strap being secured to said upstanding second side panel at said lower end thereof.

US Pat. No. 10,507,129

PELVIC FRACTURE SPLINT

1. A pelvic fracture splint, consisting of:an elongated first portion having a first end and an opposing second end and defining a length, the first elongated portion being adapted for supporting hips of a person suffering a pelvic fracture;
a plurality of rigid splints oriented orthogonal to the length of the first elongated portion and spaced apart along the first elongated portion, the plurality of rigid splints includes a first group of multiple rigid splints and a second group of multiple rigid splints, wherein the first and second groups of multiple rigid splints are spaced apart along the length of the first elongated portion and adapted for supporting opposite sides of the pelvis;
a second portion consisting of an opening defined therein, the second portion being made from a flexible, nonelastic material, the second portion having a first end attached to the first elongated portion and extending downward from the first elongated portion and having a second end, wherein the second end is free-standing and adapted for wrapping about and supporting a groin area of the person suffering the pelvic fracture, further wherein the second end is attached to the first elongated portion; and
a plurality of fastener strips extending from the first end of the first elongated portion, each of the plurality of fastener strips being fastenable to the second end of the first elongated portion and the second end of the second portion to secure the first elongated portion around the hips and the second portion under the groin area of the person suffering a pelvic fracture.

US Pat. No. 10,507,128

DEVICES AND METHODS FOR REDUCING ABSORPTION

Boston Scientific Scimed,...

1. A reduced absorption device, comprising:a proximal anchor including a plurality of circumferential loops and a plurality of connectors extending between the circumferential loops, wherein the connectors extend radially outward relative to the circumferential loops; and
a distal sleeve including a frame and a membrane;
wherein the membrane includes a plurality of porous regions, wherein each porous region is configured to align with a corresponding region of an intestine configured to absorb nutrients.

US Pat. No. 10,507,127

EXPANDABLE DEVICE

EPITOMEE MEDICAL LTD., C...

1. A folded device encased in a gastric degradable swallowable encasing, the folded device comprising at least one compartment defined by a space enclosed by walls formed by an external enterically biodegradable film having a thickness of between about 3 and about 60 microns, the external enterically biodegradable film enclosing a gel-film comprising particles of at least one gel-forming compound, said gel-film having a thickness of between about 50 and about 300 microns, or a thickness of about 400, about 500, about 600, about 700, or about 800 microns, wherein upon delivery to a stomach of a subject,the folded device is transformable into an unfolded expanded form as the encasing degrades and the particles comprised in said gel-film undergo swelling with a swelling ratio of about 10 to about 100 times-fold and wherein the biodegradable film disintegrates after the device leaves the stomach.

US Pat. No. 10,507,126

ENDOSCOPE HAVING A GRASPING TOOL AND A METHOD FOR REMOVING A STENT FROM A PATIENT

1. A method of removing a stent from a patient, the method comprising:providing a grasping tool comprising:
a first jaw having a first connecting portion and a second jaw having a second connecting portion, with the first connecting portion and the second connecting portion connected together by a fold and combining to define a proximal end of the grasping tool, with the proximal end of the grasping tool having a first thickness, each of the first jaw and the second jaw comprising an intermediate portion having a second thickness and a gripping portion located at a distal end of the grasping tool and having a third thickness; where the intermediate portion is located to extend between the first connecting portion and the second connecting portion at the proximal end of the grasping tool and the gripping portion at the distal end of the grasping tool, with the second thickness being less than the first thickness and less than the third thickness; and
a sheath disposed around the grasping tool, with the sheath having a first proximal end and a second distal end;
coupling the grasping tool to an endoscope;
inserting the endoscope through a urethra and into a bladder of the patient;
identifying a gripping location on the stent with the endoscope;
deploying the grasping tool to an open state by advancing the first jaw and the second jaw of the grasping tool out of the second distal end of the sheath;
locating the gripping portion of the respective first jaw and second jaw at the gripping location of the stent;
sliding an external surface of the first jaw and the second jaw of the grasping tool against an internal surface of the second distal end of the sheath by retracting the first jaw and the second jaw of the grasping tool into the second distal end of the sheath and closing the gripping portion of the respective first jaw and the second jaw onto the gripping location on the stent; and
retracting the endoscope, the grasping tool, and the stent from the bladder and the urethra of the patient.

US Pat. No. 10,507,125

STENT

Medfirst AG, Balzers (LI...

1. A stent for transluminal implantation into hollow organs, the stent comprising:a substantially tubular body extending in a longitudinal direction, wherein the substantially tubular body is configured to be converted from a compressed state having a first cross-sectional diameter into an expanded state having an enlarged second cross-sectional diameter,
wherein the stent comprises a plurality of groups of cells in the expanded state,
wherein each group of cells comprises an equal number of cells,
wherein each group of cells comprises three or more diamond-shaped cells that are defined by bordering elements formed by the tubular body and defined by connection sections at locations where the bordering elements intersect,
wherein adjacent diamond-shaped cells of each group of cells are connected by one of the connection sections,
wherein each group of cells is arranged so that the connection sections connecting adjacent diamond-shaped cells in each group of cells are oriented in a straight line that is parallel to the longitudinal direction,
wherein diamond-shaped cells of a first group of the plurality of groups of cells are more elongated in the longitudinal direction than diamond-shaped cells of a second group of the plurality of groups of cells in order to form a chamfered front face end of the stent.

US Pat. No. 10,507,124

LATTICE

1. An endovascular prosthesis, the prosthesis comprising:a lattice having segments that define a plurality of openings with the segments of the lattice forming a unitary structure;
wherein the segments are configured to resist dilation and creep and comprise one or more segments that are configured to expand radially into an enlarged first diametrical dimension having a first length and one or more segments that are resistant to further radial expansion having a second length, and the first length is greater than the second length; and
wherein the lattice is operable for enlargement to a first diametrical dimension when unconstrained and to a second diametrical dimension when distensive force is applied thereto and the one or more segments resistant to further radial expansion are plastically deformed or broken within a length of the one or more segments in response to the distensive force to expand the lattice to the second diametric dimension and the one or more segments that are configured to expand radially are under load at the second diametric dimension.

US Pat. No. 10,507,123

SELF-EXPANDABLE SCAFFOLDING DEVICE FOR THE TREATMENT OF ANEURYSMS

MONARCH BIOSCIENCES, INC....

1. A stent comprising:a first longitudinally extended cylinder having a C-shaped cross-section, the first cylinder comprising a plurality of first longitudinal struts and an array of first radial struts extending between the first longitudinal struts; and
a second longitudinally extended cylinder having a C-shaped cross-section, the second cylinder comprising a plurality of second longitudinal struts and an array of second radial struts extending between the second longitudinal struts;
wherein the first cylinder and the second cylinder are configured to form a dense mesh when assembled, and
wherein the first and second longitudinally extended cylinders further comprise S-shaped struts that connect to and extend from a corresponding longitudinal central strut towards a corresponding longitudinal edge strut, curve around to extend towards the corresponding central strut, and curve around to extend to and connect to the corresponding edge strut.

US Pat. No. 10,507,121

DEVICE AND METHOD TO DECODE VOLITIONAL MOTOR COMMANDS USING A BIOMECHANICAL MODEL FOR CONTROLLING A PROSTHETIC LIMB

HRL Laboratories, LLC, M...

1. A system for decoding volitional motor commands for a prosthetic device, the system comprising:a prosthetic limb and an actuator connected with the prosthetic limb;
a controller in connection with the prosthetic limb, wherein the controller is configured to implement a control feedback loop that specifies a joint torque for the prosthetic limb; and
one or more processors and a non-transitory computer-readable medium having executable instructions encoded thereon such that when executed, the one or more processors perform operations of:
using a biomechanical model and physical action data, relating biological signal data to kinetic data, the physical action data including at least one of position, joint angle, speed, and acceleration of at least part of a limb, the biological signal data including at least one of recorded neural signals and recorded muscle signals, the kinetic data including at least one of force, power, torque, and stress;
mapping from inferred joint angles onto the biological signal data using a Hidden Markov Model (HMM);
generating joint angle commands to achieve at least one of an intended position and movement of the prosthetic limb, wherein the biomechanical model constrains the joint angle commands to those that are biomechanically feasible within the biomechanical model;
using the HMM to constrain the joint angle commands to be continuous; and
sending the joint angle commands to the controller to cause the joint angle commands to be applied by the actuator connected with the prosthetic limb, wherein the actuator causes mechanical motion of the prosthetic limb based on the at least one of the intended position and movement of the prosthetic limb.

US Pat. No. 10,507,120

SYSTEMS AND METHODS FOR PERFORMING SURGICAL PROCEDURES AND ASSESSMENTS

NuVasive, Inc., San Dieg...

1. A spinal access cannula comprising:a dilating cannula having an outer surface with a continuous cross section from a proximal end to a distal end of the dilating cannula except for a tapered portion near the distal end that tapers to a smaller diameter toward the distal end and having an inner surface defining an inner lumen extending from the proximal end to the distal end, the distal end of the dilating cannula having a distal central opening therethrough in communication with the inner lumen and in line with a central longitudinal axis of the dilating; and
a single stimulation electrode fixed at the tapered portion and on the outer surface of the dilating cannula, and exposed at only a radial portion of the outer surface of the dilating cannula, wherein the radial portion comprises an arc on the outer surface of the dilating cannula, wherein the length of the arc is less than the circumference of the outer surface of the dilating cannula, wherein all other portions of the distal end of the dilating cannula has no exposed stimulation electrode.

US Pat. No. 10,507,119

SPINAL INTERBODY DEVICE, SYSTEM AND METHOD

AESCULAP IMPLANT SYSTEMS,...

1. A spinal interbody device, comprising:an interbody device configured to be placed between adjacent vertebrae of a spinal column, the interbody device including,
an anterior surface,
a posterior surface substantially opposed to the anterior surface,
a lateral surface extending from the anterior surface to the posterior surface,
a medial surface opposed to the lateral surface and extending from the anterior surface to the posterior surface,
a superior surface connected to each of the anterior surface, posterior surface, lateral surface, and medial surface,
an inferior surface opposed to the upper surface and connected to each of the anterior surface, posterior surface, lateral surface, and medial surface,
an opening extending from the superior surface through the inferior surface, and at least one projection extending from at least one of the superior surface and inferior surface of the interbody device, the at least one projection including a self cutting structure, and the at least one projection configured to prevent movement of the interbody device relative to the adjacent vertebrae when implanted, wherein the self cutting structure includes a first face and a second face and a blade defined by the first face and the second face, a back surface formed opposite to the blade, the blade facing in a direction of implantation of the interbody device, and
a ledge surface formed in front of the first face and the second face and opposite to the back surface,
wherein the first face and the second face ramp upwardly from the ledge surface to form the blade.

US Pat. No. 10,507,118

3D PRINTED OSTEOGENESIS SCAFFOLD

MCA Group, LLC, Menlo Pa...

1. An osteogenesis scaffold configured for spinal fusion, comprising:a superior support surface;
an inferior support surface;
a plurality of arcuate struts separating the superior and inferior support surfaces, the plurality of arcuate struts configured to permit a predetermined amount of compression of the scaffold in a superior to inferior direction by deformation of at least some of the arcuate struts and the plurality of arcuate struts comprising a material having a strut material modulus;
the scaffold having a functional modulus which is different than the strut material modulus and is the result of the strut modulus and the architecture of the implant.

US Pat. No. 10,507,117

INTERVERTEBRAL IMPLANTS, SYSTEMS, AND METHODS OF USE

DePuy Synthes Products, I...

1. An intervertebral implant frame comprising:a support member that defines at least two fixation element receiving apertures, each of the fixation element receiving apertures configured to receive a respective bone fixation element to thereby attach the intervertebral implant frame to first and second vertebral bodies, respectively when the intervertebral implant frame is disposed in an intervertebral space defined by first and second surfaces of the first and second vertebral bodies, respectively;
a first arm that extends from the support member and includes a first inner surface, and a first outer surface opposite the first inner surface; and
a second arm that extends from the support member and includes a second inner surface spaced from the first inner surface along a first direction, the second arm including a second outer surface opposite the second inner surface, the second arm defining a first width, a second width greater than the first width, and a third width greater than the second width, each of the first, second, and third widths measured from the second inner surface to the second outer surface along the first direction, the first width measured at a first location, the second width measured at a second location farther from the support member than the first location is from the support member, and the third width measured at a third location farther from the support member than the second location is from the support member;
wherein the first and second inner surfaces define a gap configured to receive a spacer body, the first arm comprises a first column of teeth that extends from the first inner surface, the second arm comprises a second column of teeth that extends from the second inner surface, such that the first and second columns of teeth are configured to engage the spacer body when the spacer body is received in the gap, and
wherein the first inner surface includes a first inner surface portion, the second inner surface includes a second inner surface portion, each of the first and second inner surface portions is angled toward the other of the first and second inner surface portions as they extend in a direction away from the support member, the first inner surface portion extends to the first column of teeth, and the second inner surface portion extends to the second column of teeth.

US Pat. No. 10,507,116

EXPANDABLE INTERVERTEBRAL FUSION DEVICE

INTEGRITY IMPLANTS INC., ...

1. A method for implanting an expandable fusion device between two adjacent vertebrae comprising:obtaining an expandable fusion device for implantation between two adjacent vertebrae, the device comprising
an actuator comprising a drive feature and a longitudinal axis; a wedge assembly coupled to the actuator;
a ramp assembly slidably coupled with the wedge assembly;
an upper endplate assembly slidably coupled with the ramp assembly; and a lower endplate assembly slidably coupled with the ramp assembly;
wherein, the device has a width comprising an external width of at least one of the upper endplate assembly and the lower endplate assembly;
wherein, the device has a height comprising an external distance between the upper endplate assembly and the lower endplate assembly;
wherein, actuation of the drive feature by a first number of actuations in a first actuation direction increases the width without increasing the height; and,
wherein, actuation of the drive feature by a second number of actuations beyond the first number of actuations in the first actuation direction increases at least one of the height and the width;
inserting the device, having the width and the height, between two adjacent vertebrae;
actuating the drive feature by the first number of actuations in the first actuation to increase the width without increasing the height; and,
actuating the drive feature by the second number of actuations beyond the first number of actuations in the first actuation direction to increase at least one of the height and the width;
attaching an inserter to the expandable fusion device, the device having the width and the height and comprising the drive feature.

US Pat. No. 10,507,115

DYNAMIC SPINAL SEGMENT REPLACEMENT

MEDSMART INNOVATION, INC....

1. A vertebral implant assembly comprising:a prosthetic vertebral body for insertion into a spinal column, said prosthetic vertebral body having a fastener receiving member pivotally attached to the prosthetic vertebral body;
a pedicle fastener having at least two distinct fastening portions, said distinct fastening portions comprising a first fastening portion receivable by the fastener receiving member of the prosthetic vertebral body, and a second fastening portion configured to fasten to cancellous bone,
wherein both the first and second fastening portions are threaded, and wherein the thread of the first fastening portion is finer than the thread of the second fastening portion,
wherein the pedicle fastener has a central aperture running along an axis through each fastening portion for receiving a guide wire therethrough.

US Pat. No. 10,507,114

UNIVERSAL PROSTHETIC HEAD FOR HIP PROSTHESIS

1. A prosthetic head for fixing to a cotyle of a hip prosthesis, the prosthetic head comprising:a body having a concave shape, said body having an external surface and an internal surface and a lower edge, the lower edge defining a circumference of said body;
a plurality of through holes formed in said body;
a plurality of screws extending respectively through at least some of said plurality of through holes, said plurality of screws adapted to be screwed into the cotyle;
a projection extending from the internal surface of said body so as to define an annular;
a truncated-conical portion formed in the internal surface of said body and extending from the lower edge of said body, said truncated-conical portion adapted to couple with a truncated-conical portion of an insert received in said body;
an insert having an external surface and an internal surface, said insert having a truncated-conical part coupled with the truncated-conical portion of said body, said insert having an annular step extending from the internal surface of said insert and having a projection of a Morse cone shape extending from the annular step;
a ball having a cavity of a Morse cone shape, the cavity housing the projection of said insert; and
a distal cup adapted to be fixed to a stem that is to be attached to a femur, said distal cup having a concave cap shape, said distal cup receiving said ball therein.

US Pat. No. 10,507,113

REVERSE TOTAL HIP REPLACEMENT

1. A method for a total reverse hip replacement comprising:a) implanting an acetabular base that is formed as a spherical segment having a spherical interface surface that extends between a first flat surface and a second flat surface parallel to the first flat surface and having fastener tunnels that extend in parallel to the first and second flat surfaces and through a bridge portion of the acetabular base, by:
i) reaming a human acetabulum to reach cancellous bone using a series of reamers of increasing diameter, each reamer having a surface comprising a partial spherical shell and an open apex formed to preserve thickness of a medial acetabular wall;
ii) orienting the fastener tunnels of the acetabular base to define an anterior-to-posterior fastener trajectory within the acetabulum;
iii) press-fitting the acetabular base into the acetabulum, according to the defined anterior-to-posterior fastener trajectory;
iv) fastening the acetabular base to the acetabulum;
b) fixing a substantially hemispheric acetabular ball into the acetabular base;
c) implanting, into a transected femur, a femoral stem portion of a femoral component, wherein the femoral component further comprises a cup-shaped portion; and
d) fitting the cup-shaped portion of the femoral component against the surface of the acetabular ball.

US Pat. No. 10,507,112

IMPLANT ANCHORING DEVICE

Zimmer, Inc., Warsaw, IN...

1. A method of delivering an anchor assembly into a bone, comprising:threading an elongated porous anchor into a bone until a leading end of the elongated porous anchor is positioned inside the bone and a trailing end of the elongated porous anchor is positioned at or beneath an outer surface of the bone, wherein said threading leaves a top exterior surface of the elongated porous anchor exposed along the outer surface of the bone, the top exterior surface being porous for receiving tissue ingrowth, wherein the elongated porous anchor includes a central longitudinal axis and a cannula that extends longitudinally within the elongated porous anchor along the central longitudinal axis, and wherein the elongated porous anchor includes an exterior thread that is made entirely of a highly porous metal material having a porosity of between 55% and 90%;
positioning soft tissue in contact with the top exterior surface of the elongated porous anchor after said threading so that the soft tissue can grow into the top exterior surface; and
advancing a fastener within the cannula of the elongated porous anchor after said threading of the elongated porous anchor into the bone.

US Pat. No. 10,507,111

MAGNETIC PROSTHETIC

1. An artificial joint prosthesis, comprising:a bone-facing surface configured to face a bone-prosthesis interface in vivo;
a first component comprising a contact surface, the first component fabricated, via at least an additive manufacturing method, from at least one polymer including a plurality of magnetic particles embedded in a first polymer matrix; and
a second component fabricated, via at least an additive manufacturing method, from at least one polymer including a plurality of magnetic particles embedded in a second polymer matrix;
wherein the plurality of magnetic particles embedded in at least one of the first polymer matrix and the second polymer matrix is distributed within the surrounding polymer as a variable magnetic fraction comprising a variable composition between 70.0% and 90.0% magnetic material and is configured to create a magnetic field about the artificial joint, directed to facilitate articulation of the artificial joint in vivo.

US Pat. No. 10,507,110

BONE GRAFT CAGE

DePuy Synthes Products, I...

1. A device for containing bone graft material, comprising:an outer sleeve extending longitudinally from a first end to a second end and sized and shaped to correspond to a profile of an outer surface of a target bone, the outer sleeve including a first proximal longitudinal split extending along a length thereof and a first distal longitudinal split extending along a length thereof;
an inner sleeve connected to the outer sleeve via at least one strut so that a bone graft collecting space is defined therebetween, the inner sleeve sized and shaped to correspond to a profile of a medullary canal of the target bone, the inner sleeve including a second distal longitudinal split extending along a length thereof; and
an interstitial mesh extending circumferentially between the inner and outer sleeves to hold graft material in the bone graft collecting space, the interstitial mesh including a third longitudinal split extending along a length thereof to form a distal longitudinal slot along the length of the device so that a distal side of the device may be spread open to open the distal longitudinal slot from the outer sleeve, through the interstitial mesh and the inner sleeve to a space radially within the inner sleeve.

US Pat. No. 10,507,109

NATIVE VALVE REPAIR DEVICES AND PROCEDURES

Edwards Lifesciences Corp...

1. A valve repair system for repairing a native valve of a patient during a non-open-heart procedure, the valve repair system comprising:a delivery device having at least one lumen;
a valve repair device configured to be delivered through the lumen of the delivery device, and configured to attach to a native valve of a patient, the valve repair device comprising:
a pair of paddles that are movable between an open position and a closed position;
a first gripping member, a second gripping member, a third gripping member, and a fourth gripping member, wherein the paddles and the gripping members are configured to attach to the native valve of the patient;
wherein the first gripping member, the second gripping member, the third gripping member, and a fourth gripping member each have a free end and a fixed end;
wherein the fixed end of the first gripping member, the fixed end of the second gripping member, the fixed end of the third gripping member, and the fixed end of the fourth gripping member are all connected together;
a gripper control mechanism comprising a first gripper control line connected to the first gripping member; a second gripper control line connected to the second gripping member; a third gripper control line connected to the third gripping member; and a fourth gripper control line connected to the fourth gripping member;
wherein a first paddle of the pair of paddles and the first and second gripping members are configured to attach to a first native valve leaflet;
wherein pulling the first gripper control line into the delivery device while releasing the second gripper control line from the delivery device causes a space between the first paddle and the first gripping member to be greater than a space between the first paddle and the second gripping member, such that the first native valve leaflet is only attached to the first paddle and the second gripping member until the first control line is released.

US Pat. No. 10,507,107

IMPLANTABLE DEVICE FOR IMPROVING OR REMEDYING VALVULAR INCOMPETENCE

coramaze technologies Gmb...

1. An implantable device for improving or remedying valvular incompetence, comprising a sealing body and at least one anchoring element fastened thereto, said at least one anchoring element is configured to anchor said sealing body in an atrium of the heart, wherein said sealing body includes at least one cavity, which is fillable with a fluid following implantation of the device and being capable of maintaining a constant volume of said fluid during cardiac phases, said sealing body including at least one cavity disposed about a main body and lying in a direction of a longitudinal extent of said sealing body, wherein said main body is a flexible tube and further wherein a lateral surface of said tube includes multiplicity of cuts perpendicular to the direction of longitudinal extent.

US Pat. No. 10,507,106

AORTIC INSUFFICIENCY REPAIR DEVICE AND METHOD

Edwards Lifesciences Corp...

1. A support frame configured to be implanted in a native heart valve, the support frame comprising:an inflow end and an outflow end;
a radially expandable and collapsible annular main body including a plurality of angled struts and including a plurality of apices formed by the intersection of respective adjacent struts; and
one or more pairs of clipping arms, each of the one or more pairs of clipping arms being located between two of the respective adjacent struts defining an apex of the main body, each of the clipping arms comprising a fixed end portion and a free end portion, the free end portion being offset from the apex in a direction toward the inflow end, the clipping arms defining a leaflet-receiving space between two opposing surfaces of the clipping arms for engaging portions of adjacent native leaflets of the native heart valve therebetween;
wherein the clipping arms are disposed within an outer diameter of the support frame defined by the plurality of angled struts.

US Pat. No. 10,507,105

PROSTHETIC VALVE WITH TISSUE ANCHORS FREE FROM LATERAL INTERCONNECTIONS

CARDIOVALVE LTD., Or Yeh...

1. A prosthetic valve for implantation within a native mitral valve, the prosthetic valve comprising:an annular valve body having an upstream end, a downstream end opposite the upstream end, and an intermediate portion extending between the upstream end and the downstream end;
a plurality of atrial anchoring arms configured to extend from the intermediate portion of the valve body in a generally radially outward direction; and
a plurality of ventricular anchoring legs configured to extend from the intermediate portion of the valve body in a generally radially outward direction, each ventricular anchoring leg having a proximal end secured to the annular valve body and a terminal end opposite from the proximal end, wherein at least one atrial anchoring arm is configured to extend radially outward beyond the terminal ends of the ventricular anchoring legs,
wherein beyond locations of connection to the intermediate portion, the atrial anchoring arms and the ventricular anchoring legs are devoid of lateral interconnections therebetween,
wherein the at least one atrial anchoring arm is configured to extend in the generally radially outward direction from a single location of connection to the intermediate portion of the valve body,
wherein a proximal portion of at least one ventricular anchoring leg is configured to extend in an upstream direction, the proximal portion including the proximal end of the at least one ventricular anchoring leg, and
wherein the annular valve body comprises a strut extending from the location of connection of a first ventricular anchoring leg of the plurality of ventricular anchoring legs, wherein an entire length of the strut is situated midway between two adjacent atrial anchoring arms.

US Pat. No. 10,507,104

SUTURELESS VALVE PROSTHESIS DELIVERY DEVICE AND METHODS OF USE THEREOF

Suzhou Jiecheng Medical T...

1. A delivery device for delivering a heart valve prosthesis, the delivery device comprising:a first sheath configured to encase at least a portion of an expandable support frame of the heart valve prosthesis;
a second sheath configured to encase a valve clasper of the heart valve prosthesis, the valve clasper being coupled to the expandable support frame; and
a control unit operably coupled to the first and second sheaths,
wherein along a longitudinal axis, the first sheath is distal to the second sheath, and the second sheath is distal to the control unit, and
wherein the second sheath comprises a bent configuration in which (i) the second sheath has an angle of between about 5 degrees to 60 degrees and (ii) the second sheath maintains the bent configuration, at the same angle ±5 degrees in the absence of a force applied thereto, during delivery of the heart valve prosthesis and removal of the delivery device.

US Pat. No. 10,507,103

ASSEMBLY FOR DELIVERING A PROSTHETIC HEART VALVE

Edwards Lifesciences Corp...

1. A medical assembly, comprising:a delivery system comprising an inflatable balloon along a distal end portion of the delivery system;
a prosthetic valve retained in a radially compressed state over the inflatable balloon;
a loader comprising a tube portion extending over the prosthetic valve and the inflatable balloon of the delivery system; and
an introducer comprising a sleeve and a housing attached to a proximal end of the sleeve;
wherein the sleeve is configured to be inserted into a blood vessel of a patient so that an inner passageway of the sleeve is in fluid communication with the blood vessel and the housing is located outside the blood vessel;
wherein the tube portion of the loader is configured to pass through the housing and into the inner passageway of the sleeve so that the delivery system and the prosthetic valve can be passed through the housing while the prosthetic valve is inside the tube portion and then advanced from the tube portion through the inner passageway of the sleeve and into the blood vessel after the sleeve is inserted into the blood vessel;
wherein the introducer comprises one or more valves located inside the housing and configured to engage an outer surface of the tube portion of the loader when the tube portion is inserted into the introducer; and
wherein the loader further comprises a cap portion coupled to a proximal end portion of the tube portion and a seal member inside the cap portion and engaging an outer surface of the delivery system.

US Pat. No. 10,507,102

PROSTHETIC VALVE FOR REPLACING MITRAL VALVE

Edwards Lifesciences Corp...

1. A method of reducing regurgitation of the native mitral valve of a heart, the native mitral valve having a native annulus, posterior and anterior native valve leaflets, wherein the native leaflets define a regurgitant orifice area therebetween that allows blood to flow from the left ventricle to the left atrium during ventricular systole, the method comprising:delivering a prosthetic apparatus in a compressed state through the patient's vasculature to the heart;
expanding the prosthetic apparatus from the compressed state to an expanded state;
positioning a spacer body of the prosthetic apparatus between the native leaflets;
positioning a lower anchor of the prosthetic apparatus on an inferior side of the anterior native valve leaflet;
positioning a second lower anchor of the prosthetic apparatus on an inferior side of the posterior native valve leaflet;
positioning a first upper anchor of the prosthetic apparatus on a superior side of the anterior native valve leaflet; and
positioning a second upper anchor of the prosthetic apparatus on a superior side of the posterior native valve leaflet;
wherein the spacer body occupies space within the regurgitant orifice area to reduce regugitation through the native mitral valve during ventricular systole.

US Pat. No. 10,507,101

VALVED CONDUIT

1. A valved conduit comprising:a conduit including a first conduit having a first conduit distal end and a second conduit having a second conduit proximal end, the conduit has a conduit inner surface and a conduit outer surface the first conduit distal end defining a plurality of commissure slots; and
a valve structure including at least one leaflet, each leaflet having a free edge and a leaflet attachment edge, the leaflet attachment edge disposed between the first conduit distal end and the second conduit proximal end that are coaxial therebetween defining a junction,
wherein the leaflet attachment edge is coupled between the first conduit distal end and the second conduit proximal end,
wherein the first conduit distal end, the leaflet attachment edge, and the second conduit proximal end are coupled together with suture,
wherein the first conduit distal end comprises a plurality of first conduit apertures, and wherein the second conduit proximal end comprises a plurality of second conduit apertures, wherein the leaflet attachment edge further comprises a leaflet aperture inner row including a plurality of leaflet apertures, wherein the leaflet attachment edge is disposed within the junction such that the leaflet aperture inner row is adjacent the conduit inner surface, wherein the suture passes through the leaflet apertures and extends along a conduit inner surface coupling the first conduit distal end, the leaflet attachment edge, and the second conduit proximal end together.

US Pat. No. 10,507,099

INTRAOCULAR LENS INSERTION APPARATUS

Kowa Company, Ltd., Nago...

1. An intraocular lens insertion apparatus comprising:a distal end member which is inserted through an incision in an eyeball of a patient;
an opening member provided for the distal end member through which an intraocular lens is ejected; and
an indicator provided for the distal end member configured to indicate that an entire part of the opening member is inside a cornea of the eyeball or inside a sclerocornea of the eyeball with respect to an external flap of the incision,
wherein the indicator indicates that the entire part of the opening member is inside the cornea of the eyeball or inside the sclerocornea of the eyeball based on a relation, in a top view of the distal end member of the intraocular lens set in the intraocular lens insertion apparatus, between (a) a length of a part of the distal end member in an insertion direction of the distal end member inserted into the incision and (b) a length of a part of the distal end member in a direction perpendicular to the insertion direction, wherein the part of the distal end member is a part projected from an internal flap of the incision into the eyeball.

US Pat. No. 10,507,097

SURGICAL IMPLANT DEVICES AND METHODS FOR THEIR MANUFACTURE AND USE

Edwards Lifesciences Card...

9. An assembly, comprising:a stent member, wherein the stent member is circumferentially expandable and contractible;
an adjustment member, wherein the adjustment member is coupled to the stent member and configured for circumferentially expanding and contracting the stent member;
a rotatable shaft; and
a locking mechanism coupled to the shaft and movable between a lock configuration and a release configuration,
wherein the locking mechanism is configured to engage the adjustment member such that axial movement of the shaft results in corresponding axial movement of the adjustment member when locking mechanism is in the lock configuration, and
wherein the locking mechanism is configured to disengage the adjustment member such that the shaft can move axially relative to the adjustment member when the locking mechanism is in the release configuration.

US Pat. No. 10,507,096

ARTIFICIAL BLOOD VESSEL AND PREPARATION METHOD THEREOF

1. An artificial blood vessel, sequentially comprising a cortex layer, a fibroblast layer, a smooth muscle cell layer, an endothelial cell layer and an inner cavity from outside to inside of the artificial blood vessel; wherein the cortex layer is formed by spraying a synthetic polymer solution through plasma spraying, electrospraying or electrospining technologies; the fibroblast layer, the smooth muscle cell layer and the endothelial cell layer are formed by infusing, through an intra-mold pouring technology or stacking, through a 3D printing technology a natural polymer solution containing cells; growth factors and anticoagulation factors with a mass percent of 0.01-1% are compounded in the natural polymer solution; and a diameter of the inner cavity is 0.1-8 mm.

US Pat. No. 10,507,094

VAGINAL PESSARY

1. A vaginal pessary, which comprises: a cylindrical body which terminates in blunt, rounded or shaped distal and proximal ends, which is yieldably extensible into an uncoiled elongate configuration for placement in an insertion/withdrawal device and self-retracting into a helically or spirally coiled configuration having a non-cylindrical overall shape upon leaving the insertion/withdrawal device; and means for withdrawal of the pessary from a vaginal cavity attached to the proximal end of the cylindrical body, wherein the vaginal pessary is adapted for use within the vaginal cavity and manages pelvic organ prolapse.

US Pat. No. 10,507,093

ORAL APPLIANCE FOR DELIVERY OF MEDICAMENTS AND/OR OTHER SUBSTANCES

Emanate Biomedical, Inc.,...

1. An oral appliance configured for delivering a medicament to at least a portion of teeth and/or soft tissue areas inside an oral cavity, the oral appliance comprising an interior surface having a medicament disposed in or on at least a portion of and/or all of the interior surface of the oral appliance, the interior surface being formed to fit contours of at least the portion of the teeth and/or soft tissue areas inside the oral cavity and being configured for holding the medicament in contact with at least the portion of the teeth and/or soft tissue areas inside the oral cavity to deliver the medicament thereto, wherein the oral appliance is made by a computer implemented method, the computer implemented method comprising creating a digital image of the oral cavity by obtaining a baseline digital image of at least the portion of the teeth and/or soft tissue areas of the oral cavity using an imaging device; obtaining a first digital image of the oral appliance corresponding to the at least the portion of the teeth, and/or soft tissue areas of the oral cavity of the baseline image, creating a second digital image based on the baseline image corresponding to at least the portion of the teeth and/or soft tissue areas of the oral cavity in need of treatment with the medicament; combining the first digital image and the second digital image to form a third digital image of the oral appliance that comprises a treatment area for treatment with the medicament and storing the third digital image in the computer and instructing a 3D printer to produce the oral appliance from at least the stored third digital image, and producing the oral appliance in a layered and monolithic form having a medicament disposed in or on at least a portion and/or all of the interior surface, wherein the layered and monolithic oral appliance is infused with the medicament.

US Pat. No. 10,507,092

VIBRATION COMPENSATION SYSTEM FOR POWER TOOTHBRUSHES

KONINKLIJKE PHILIPS N.V.,...

1. A vibration compensation system for a power toothbrush appliance, comprising;a housing which is adapted to be grasped by a user;
an actuator that comprises a stator having a first moment of inertia and a rotor having a second moment of inertia, the rotor at a forward end thereof having mounted thereon a bristle member for cleaning the teeth, wherein the stator surrounds at least a portion of the rotor, wherein the actuator in operation generates torque for driving the rotor and hence the bristle member, and wherein the stator and the rotor are configured to move in opposing directions during operation of the power toothbrush appliance; and
a spring arrangement comprising:
a first spring element or assembly connected between and fixedly attached to both the stator and the housing or an element fixed to the housing, wherein the first spring element has a first spring constant; and
a second spring element connected between and fixedly attached to both the rotor and the housing or an element fixed to the housing, wherein the second spring element has a second spring constant, wherein the ratio of the first and second spring constants is approximately equal to the ratio of the first and second moments of inertia that there is substantially no resulting torque transmitted to the housing during operation of the power toothbrush appliance, and hence substantially no vibration of the housing during operation of the power toothbrush appliance,
wherein the first and second spring elements comprise a single spring, wherein the single spring is connected to the housing or an element connected to the housing at a selected point between the first and second spring elements, and
wherein the first and second spring elements are disconnectable from each other, further wherein the second spring element is part of an assembly which includes a distal portion of the housing, a brushhead assembly and an interface part which connects with an interface part on a remainder of the appliance.

US Pat. No. 10,507,091

DENTURE-SECURING DEVICE

1. A denture and denture-securing device assembly comprising:a denture that is affixable to a human gum of a human mouth, the denture comprising a first side and a second side affixable to the gum at left and right sides of the mouth, respectively, the denture further comprising a channel configured to receive the gum, wherein an outer face of the denture is configured to be arranged outward of the gum when the gum is received within the channel, the outer face of the denture terminating in an outer edge; and
a denture-securing device for securing the denture to the gum, the denture-securing device comprising at least one absorbent and flexible pad installable on the first side and the opposite second side of the denture, wherein the at least one pad comprises an embossed outer side configured to face a human gum when the pad is installed on the denture; and further wherein
the denture-securing device is mounted on the denture such that the at least one pad is flexed and placed into the channel of the denture, and a portion of the at least one pad folds over the outer edge of the denture and covers the outer face of the denture at least partially, and such that the at least one pad is configured to be sandwiched between the denture and a human gum and to be moistened and adhered to the human gum via suction of the human gum towards the embossed outer side of the at least one pad.

US Pat. No. 10,507,089

IMAGING APPARATUS WITH SIMPLIFIED OPTICAL DESIGN

Align Technology, Inc., ...

1. A method of generating a three-dimensional virtual model of an intraoral object, comprising:capturing, by an imaging apparatus for performing intraoral scans, surface scan data of the intraoral object while changing a position of at least one lens of focusing optics of the imaging apparatus, wherein the surface scan data comprises depth data for a plurality of points of the intraoral object;
adjusting the depth data for one or more of the plurality of points based at least in part on the position of the at least one lens associated with the depth data for the one or more of the plurality of points using one or more compensation models, wherein the one or more compensation models compensate for changes in magnification associated with different positions of the at least one lens, and wherein the one or more compensation models provide different adjustments to the depth data for the one or more of the plurality of points for the different positions of the at least one lens; and
generating the three-dimensional virtual model of the intraoral object using the adjusted depth data.

US Pat. No. 10,507,087

METHODS AND APPARATUSES FOR FORMING A THREE-DIMENSIONAL VOLUMETRIC MODEL OF A SUBJECT'S TEETH

Align Technology, Inc., ...

1. An intraoral scanning system, comprising:a hand-held wand configured to operate with one or more sensors to detect infrared and visible light, wherein the one or more sensors comprises an image sensor;
a sleeve configured to be placed over a distal end of the hand-held wand having a window at a distal end region; and
one or more processors operably connected to the hand-held wand, the one or more processors configured to:
receive visible light information and infrared information from the one or more sensors;
determine, in real time, surface information from the visible light information and generate a three-dimensional (3D) surface model of a subject's teeth using the surface information;
display the 3D surface model on a display screen in real time as the hand-held wand is moved;
capture, in real time using the image sensor, one or more two-dimensional (2D) images of an internal region of the subject's teeth from the infrared information; and
display, on the display screen, the one or more 2D images of the internal region of the subject's teeth.

US Pat. No. 10,507,085

STRUCTURE ENABLING CONTINUOUS ANGULAR ADJUSTMENT FOR FIXING A SINGLE DENTAL DEVICE INTO AN IMPLANT

Elsner Global LLC, Charl...

1. A fixing device for securing a dental device to a dental implant, the fixing device comprising:an intermediate piece having
an intermediate piece central hole,
at an intermediate piece first end, a coupling surface configured to engage with a screwing tool,
a socket adjacent to said intermediate piece first end, and
a threaded outer surface at an intermediate piece second end opposite to the intermediate piece first end;
a shank having
a threaded outer surface at a shank first end,
a ball-like element at a shank second end opposite to the shank first end;
an insertion piece having
at an insertion piece first end for supporting the ball-like element of the shank,
an insertion piece second end opposite to said first end of the insertion piece for engagement with a dental implant, and
an outer conical coupling surface adjacent to the insertion piece first end; and
a joining piece having
a joining piece central hole for receiving the intermediate piece and the insertion piece,
a first outer coupling surface located at a joining piece first end, where the first outer coupling surface at least in part has a cross-section adapted for a form-fitting engagement with a dental device in a specific rotational position,
a threaded inner surface within said joining piece central hole and located at the joining piece first end,
a second outer coupling surface located at a joining piece second end opposite to said joining piece first end having a cross-section adapted for a form-fitting engagement with a dental implant in a specific rotational position, and
an inner conical seat;
wherein in an assembled state of the fixing device
the socket of the intermediate piece and the insertion piece first end holds the ball-like element of the shank in a manner that a longitudinal axis of the shank is capable of tilting with respect to a longitudinal axis of the intermediate piece at any angle within a range of 0°-25°,
the intermediate piece is secured to the joining piece so that the threaded outer surface of the intermediate piece engages with the threaded inner surface of the joining piece,
the insertion piece is secured to the joining piece by a taper fit between the outer conical coupling surface of the insertion piece and the inner conical seat of the joining piece.

US Pat. No. 10,507,084

DENTAL PROSTHESIS SYSTEM

CLINICA DENTAL COSTA CODI...

1. Dental prosthesis system, comprising:a longitudinally elongated flexible screw having a first end that includes threading configured to be received in a dental implant and a second open flexible end that can be bent inwardly by inwardly bending and having a threaded hole with threads inside of said second open flexible end and a projecting flange outside of said second open flexible end;
a transmucosal post positioned between the first end and the second flexible end of the longitudinally elongated flexible screw; and
an upper connection element having a hole at one of its ends, the upper connection element being configured to be click-coupled by click-coupling on the second open flexible end of the flexible screw by means of an inner recess in said hole corresponding with the projecting flange outside of the second open flexible end of the flexible screw,
wherein the coupling between the upper connection element and the second open flexible end of the flexible screw is reversible, whereby said upper connection element is decoupled from said flexible screw,
wherein the second open flexible end of said flexible screw has a plurality of longitudinal grooves to facilitate the inwardly bending of said second open flexible end upon coupling the upper connection element and the second open flexible end,
wherein said second open flexible end of the flexible screw has only three of said plurality of longitudinal grooves, and
wherein the second open flexible end of the flexible screw recovers its original shape when the projecting flange reaches the corresponding inner recess of the upper connection element.

US Pat. No. 10,507,083

AFFIXING AN ARTIFICIAL ELEMENT TO A SURFACE OF DENTINE, ENAMEL, BONE, OR A CORRESPONDING SUBSTITUTE MATERIAL

WOODWELDING AG, Stanssta...

1. A medical method of affixing an element to a surface, wherein the surface is a surface of dentine, tooth enamel, bone tissue, or corresponding substitute material, the method comprising the steps of:providing an attachment composition, the attachment composition comprising a mixture of:
a thermoplastic component; and
a hardenable component, the hardenable component being different from the thermoplastic component and being hardenable by cross-linking;
positioning the attachment composition relative to the surface of dentine, tooth enamel, bone tissue, or corresponding substitute material; and
activating the attachment composition to attach the attachment composition to the surface and to the element positioned relative the surface;
wherein the step of activating the attachment composition comprises activating the attachment composition via mechanical vibration,
wherein, subsequent to the step of activating, the element is affixed to the surface by the attachment composition, with the hardenable component being intertwined with and thereby mechanically connected to the thermoplastic component,
wherein the steps of providing and positioning are carried out prior to the step of activating, and
wherein the attachment composition provides a reversible attachment of the element to the surface, the attachment being releasable by causing energy to impinge upon the element until the thermoplastic component is liquefied.

US Pat. No. 10,507,082

IMPRESSION JIG ASSEMBLY

Elsner Global LLC, Charl...

1. An impression jig comprising:a main body having an inner channel and a head having an inner channel and adapted for being releasably attached to said main body,
wherein the inner channel of the main body is provided with threads and at its lower end portion, with an inner positioning surface, and
wherein the inner channel of the head is provided with threads and at its upper end portion, with an inner positioning surface,
a tubular screw adapted for guiding through the inner channel of the main body and into the inner channel of the head, said tubular screw having an inner channel, and wherein an outer surface of the tubular screw is provided with first threads at a lower end thereof and with second threads at a predetermined distance from said lower end,
a central screw, the shank of which is adapted for guiding through the inner channels of the tubular screw and the head, wherein a lower end portion of the shank is provided with threads, and wherein said shank is longer than the total length of the main body and the head when engaged with each other, and
a slide movable within the inner channel of the main body between a first position and a second position in an axial direction by means of said tubular screw, wherein the slide comprises a positioning surface on its outer side at a lower part thereof,
wherein in its first position, the slide resides partly in the main body and partly in the head, and the positioning surface of the slide engages with the upper positioning surface of the head in a form-fitting manner, and
wherein in its second position, the whole slide resides in the inner channel of the main body, and the positioning surface of the slide engages with the inner positioning surface of the main body.

US Pat. No. 10,507,081

METHODS FOR TAKING AN IMPRESSION OR SCANNING WITHOUT REQUIRING REMOVAL OF A TEMPORARY HEALING ABUTMENT

ESTHETIC IMPLANT SOLUTION...

1. A method of taking an impression or scan of a patient's oral cavity, the method comprising:providing an anatomical healing abutment/cap received within a subgingival void of a given tooth position, the anatomical healing abutment/cap being threadably coupled into an implant disposed adjacent the anatomical healing abutment/cap; and
providing a scanning body or impression post that is initially separate from the anatomical healing abutment/cap, and inserting the scanning body or impression post into an open end of the anatomical healing abutment/cap with the anatomical healing abutment/cap positioned in the subgingival void, such that insertion of the scanning body or impression post occurs without requiring removal of the anatomical healing abutment/cap;
wherein the scanning body or the impression post is selectively removable from the open end of the anatomical healing abutment/cap, and a screw is not required to selectively secure the scanning body or the impression post to the open end of the anatomical healing abutment/cap, such that the scanning body or impression post is slidably received into the open end of the anatomical healing abutment/cap, and the anatomical healing abutment/cap is threadably coupled into the implant;
wherein the anatomical healing abutment/cap and the scanning body or impression post are keyed to one another;
wherein the anatomical healing abutment/cap comprises one or more vertical grooves formed into an interior surface of the anatomical healing abutment/cap;
wherein an exterior surface of the scanning body or impression post inserted into the anatomical healing abutment/cap includes one or more vertical protrusions which mate with the one or more vertical grooves of the anatomical healing abutment/cap; and wherein:
the one or more vertical grooves comprise a plurality of vertical grooves which are of different lengths and/or widths relative to one another; and
the one or more vertical protrusions comprise a plurality of vertical protrusions which are of different lengths and/or widths relative to one another.

US Pat. No. 10,507,080

ORTHODONTIC ANCHOR SYSTEM

1. A system including an orthodontic anchor and an aligner, the system comprising:a spring mechanism having a spring mechanism inferior surface and a spring mechanism superior surface wherein the spring mechanism has a thickness in a range of 0.01 to 0.30 millimeters, the spring mechanism configured to apply a force to a portion of the aligner;
an aligner inferior interface limb having an aligner inferior interface limb inferior surface and an aligner inferior interface limb superior surface;
a first joint disposed directly between the spring mechanism and the aligner inferior interface limb, the first joint directly connecting the spring mechanism and the aligner inferior interface limb;
an aligner superior interface limb having an aligner superior interface limb inferior surface and an aligner superior interface limb superior surface;
an aligner housing wherein the aligner housing is disposed between the aligner inferior interface limb and the aligner superior interface limb;
a second joint disposed directly between the aligner superior interface limb and the aligner inferior interface limb, the second joint directly connecting the aligner superior interface limb and the aligner inferior interface limb;
an anchor mechanism anterior limb having an anchor mechanism anterior limb inferior surface and an anchor mechanism anterior limb superior surface;
a third joint disposed directly between the anchor mechanism anterior limb and the aligner superior interface limb, the third joint directly connecting the anchor mechanism anterior limb and the aligner superior interface limb wherein the aligner superior interface limb is disposed directly between the third joint and the second joint;
an elastic band retaining limb having an elastic band retaining limb inferior surface and an elastic band retaining limb superior surface wherein the elastic band retaining limb is disposed between the anchor mechanism anterior limb and the aligner inferior interface limb;
an elastic band ingress aperture wherein the elastic band ingress aperture is disposed between the elastic band retaining limb and the aligner superior interface limb; and
an anchor mechanism posterior limb having an anchor mechanism posterior limb inferior surface and an anchor mechanism posterior limb superior surface wherein the elastic band retaining limb is disposed between the anchor mechanism posterior limb and the aligner superior interface limb.

US Pat. No. 10,507,079

METHODS AND SYSTEMS FOR TREATING TEETH

ALIGN TECHNOLOGY, INC., ...

1. A method for generating a treatment plan for repositioning a patient's teeth, the method comprising:scanning a patient's teeth with a non-contact-type scanner to form a digital data set representative of a malocclusion of the patient's teeth;
receiving, by a processor, the digital data set representative of the malocclusion of the patient's teeth, wherein the processor is configured to determine at least one of an A-P correction, CR-CO discrepancy, premolar rotation, canine rotation, and teeth extrusion;
determining, by the processor, a severity of the malocclusion based on the digital data set; and
generating, by the processor, a treatment plan in response to the determined severity of the malocclusion, the treatment plan comprising a first phase and a second phase administered to the patient in a pre-selected order, wherein the first phase comprises placing a wire and bracket system on the teeth and the second phase comprises successively placing a plurality of polymeric shell appliances on the teeth, the plurality of polymeric shell appliances having tooth receiving cavities with different geometries selected to reposition the teeth towards a target arrangement.

US Pat. No. 10,507,078

TOOL FOR TREATMENT OF INTERDENTAL SURFACES

INTENSIV SA, (CH)

1. A tool for treatment of interdental surfaces,said tool having a tool longitudinal axis and a first and a second lateral end along said tool longitudinal axis;
a handle configured for coupling said tool to an appliance capable of applying a linear movement to said tool;
a strip comprising a support and including at least one longitudinal side;
said strip extending from a first lateral end of said tool along said tool longitudinal axis to a second lateral end of said tool;
said at least one longitudinal side of said strip comprising an apical edge extending along a first portion of said longitudinal axis and a coronal edge extending along a second portion of said longitudinal axis, both said apical edge and said coronal edge being straight;
an abrasive field on said at least one longitudinal side of said strip is provided with abrasive particles which are arranged on said support, said support being flat so that it is free of geometrical protrusions arranged in a regular pattern;
said abrasive field being situated at a distance of at least 0.2 mm from each of said apical edge and said coronal edge;
said at least one longitudinal side being blank between said apical edge and said abrasive field, between said coronal edge and said abrasive field, between said first lateral end and said abrasive field and between said second lateral end and said abrasive field;
wherein said abrasive field is configured for abrading and thus reducing the size of a tooth at a contact point between said abrasive field and the tooth when moving the strip in a linear motion.

US Pat. No. 10,507,075

SYSTEM FOR ENHANCED DATA ANALYSIS WITH SPECIALIZED VIDEO ENABLED SOFTWARE TOOLS FOR MEDICAL ENVIRONMENTS

1. A system for medical software tools, comprising:an image stream interface module configured to receive an image stream from a surgical camera wherein said image stream interface module includes a CPU and a GPU for processing said image stream;
a user interface overlay module configured to provide a user interface overlay adapted for presentation over the image stream by use of a video router providing a video stream to overlay an original video image;
an optical sensor located corresponding with said surgical camera for registering changes in spectral characteristics reflected from a tissue surface under inspection wherein said optical sensor provides a signal indicative of light energy detected;
a medical software tools module configured to provide a medical software tool through the user interface, the medical software tool being configured to perform an operation with respect to the image stream and provide an output adapted to be presented over the image stream, responsive to said light energy detected by said optical sensor; and
a medical image processing system for processing patient medical data and corresponding said patient medical data with momentary changes in spectral characteristics for generating optical signature data indicative of various patient conditions, wherein the medical software tool measures: a. changes in color intensity and b. rates at which said color intensities change in response to: heartbeat pushed blood, breathing pushed oxygen or light intensity or modulation from a light source.

US Pat. No. 10,507,074

OPHTHALMIC ILLUMINATION SYSTEMS, DEVICES, AND METHODS

Novartis AG, Basel (CH)

1. A method of manufacturing an ophthalmic illumination system, the method comprising:selecting a supercontinuum laser source from among multiple supercontinuum laser sources, each of the multiple supercontinuum laser sources being arranged to emit a light beam having a respective numerical aperture;
selecting a dichroic mirror from among multiple dichroic mirrors, based on the selected supercontinuum laser source, at least one parameter associated with a shape of each of the dichroic mirrors being different;
obtaining an achromatic collimator comprising a lens, the selected mirror configured to reflect a portion of the light beam towards the achromatic collimator; and
arranging the selected supercontinuum laser source and the selected mirror such that the reflected portion of the light beam has the same numerical aperture for each combination of selected supercontinuum laser source and selected mirror.

US Pat. No. 10,507,073

PACKAGE ASSEMBLY FOR STERILE AND CONVENIENT INSERTION OF DILATOR INTO SHEATH

TERUMO MEDICAL CORPORATIO...

1. A package assembly for an elongate surgical device, comprising:two or more elongate surgical devices; each of the two or more elongate surgical devices having a proximal end and a distal end;
the two or more elongated surgical devices oriented in a coiled configuration and secured to a surface, wherein the two or more elongate surgical devices are oriented in a coiled configuration such that the distal end of a first elongate surgical device may be inserted into the proximal end of a second elongate surgical device; and
a protective tube within which the one or more elongate surgical devices is disposed, wherein the protective tube has a slit that extends along a longitudinal length of the protective tube and within which said one or more elongate surgical devices are disposed.

US Pat. No. 10,507,072

STERILE STAND FOR SUPPORTING SURGICAL INSTRUMENTS

Gayle Misle, Millbrae, C...

1. In combination:an elongated surgical needle, having a lower end and an upper end, with said surgical needle having an enlarged mount at said upper end thereof;
a stand for supporting said surgical needle in a vertically disposed sterile manner;
said stand comprising:
(a) a horizontally disposed base member having a flat lower side and a flat upper side;
(b) a vertically disposed and elongated hollow sterile support tube having a lower end and an upper end;
(c) said lower end of said support tube being secured to said flat upper side of said base member so as to extend upwardly from said flat upper side of said base member;
(d) said support tube having a bore, with upper and lower ends, formed therein which extends downwardly into said upper end of said support tube; and
(e) said support tube configured to have said elongated surgical needle extending downwardly thereinto through said bore of said support tube with said enlarged mount engaging said upper end of said support tube to limit the downward movement of said surgical needle into said support tube with said support tube having a length which is sufficient whereby the entire length of said surgical needle, below said enlarged mount, is positioned in said bore of said support tube above said flat upper side of said base member.

US Pat. No. 10,507,071

HAND ACTUATED, ARTICULATING DEVICE HAVING AN ELECTRIC FORCE ENHANCEMENT SYSTEM

CAREFUSION 2200, INC., S...

17. A device comprising:a hydraulically-driven mechanical system capable of receiving an input, as an external force in at least a first direction;
a sensor coupled to the hydraulically-driven mechanical system operable to detect the received input;
an electrically-driven enhancement system connected with the hydraulically-driven mechanical system and providing an electric force enhancement during operation of the hydraulically-driven mechanical system by providing a compensating force to a hydraulically driven slave system of the hydraulically-driven mechanical system the compensating force acting on the hydraulically-driven mechanical system in the at least the first direction, wherein the electrically-driven enhancement system comprises:
a force enhancement electric element coupled to the hydraulically-driven mechanical system configured to transfer a function of the detected input from the external force and the compensating force, wherein the compensating force enhances the external force; and
a control circuit element which is coupled to the sensor and the force cement electric element and configured to transmit a control signal to energize the force enhancement electric element in the direction of the received input, wherein the enhancement electric element outputs a compensating force based on the control signal, wherein the compensating force compensating for resistance force in moving the hydraulic input receiver by enhancing the external force received at the hydraulic input receiver.

US Pat. No. 10,507,070

SINGLE PORT MULTI-INSTRUMENT SURGICAL ROBOT

1. A surgical device comprising:a main shaft being cylindrical and having proximal and distal ends and having a keyway slot along its longitudinal axis;
a main arm having proximal and distal ends where the proximal end of main arm is attached to distal end of main shaft and a surgical tool being releasably attached to the distal end of main arm;
a motor driving a friction wheel that operably engages the surface of the main shaft such that rotational motion by the friction wheel causes the main shaft to translate vertically;
a motor driving a first gear that engages a second gear about the main shaft the second gear engaging the main shaft by means of a key within the keyway slot so that rotation of the second gear causes the main shaft to rotate about its longitudinal axis while allowing the main shaft to vertically translate through the second gear; and
an introducer fitted to an incision having openings to allow the main shaft to pass therethrough so that the surgical tool attached to the main arm may be deployed at a surgical site.

US Pat. No. 10,507,066

PROVIDING INFORMATION OF TOOLS BY FILTERING IMAGE AREAS ADJACENT TO OR ON DISPLAYED IMAGES OF THE TOOLS

Intuitive Surgical Operat...

1. A system comprising:a tool having a working end;
an image capturing device disposed to capture an image of a work site, the image of the work site including an image of an object and an image of the working end of the tool, the image of the object including an image of a first portion of the object and an image of a second portion of the object, the first portion of the object being adjacent to or near the tool, and the second portion of the object being the remainder of the object;
a display; and
a processor programmed to:
determine that the tool has been energized for cauterization; and
conditioned upon determining that the tool has been energized for cauterization:
filter the image of the first portion of the object to generate a filtered image and indicate in the filtered image that the tool is energized for cauterization by improving at least one of: contrast and brightness in the first portion, but not filter the image of the second portion of the object; and
cause the image of the work site, with the filtered first portion and the non-filtered second portion, to be displayed on the display.

US Pat. No. 10,507,065

SYSTEM AND METHOD FOR ENHANCED DATA ANALYSIS WITH VIDEO ENABLED SOFTWARE TOOLS FOR MEDICAL ENVIRONMENTS

1. A system for medical software tools, comprising:an image stream interface module configured to receive an image stream from a surgical camera wherein said image stream interface module includes a CPU and a GPU for processing said image stream;
a user interface overlay module configured to provide a user interface overlay adapted for presentation over the image stream by use of a video router providing a video stream to overlay an original video image;
an optical sensor located corresponding with said surgical camera for registering momentary changes in spectral characteristics reflected from a tissue surface under inspection wherein said optical sensor provides a signal indicative of light energy detected;
a medical software tools module configured to provide a medical software tool through the user interface, the medical software tool being configured to perform an operation with respect to the image stream and provide an output adapted to be presented over the image stream, responsive to said light energy detected by said optical sensor;
a medical image processing system for processing patient medical data and corresponding said patient medical data with said momentary changes in spectral characteristics for generating optical signature data indicative of various patient conditions, wherein the medical software tool measures: a. changes in color intensity and b. rates at which said color intensities change in response to: heartbeat pushed blood, breathing pushed oxygen or light intensity or modulation from a light source; and
wherein a contrast fluorescent dye is introduced associated with said tissue under inspection in the assessment of the perfusion of tissues and organs.