US Pat. No. 10,391,404

UNIFIED PLATFORM FOR A PLURALITY OF TITLES AND GAMING DEVICES

Microsoft Technology Lice...

1. A system comprising:a memory; and
a processor in communication with the memory, wherein the processor is configured to:
provide a software development kit (SDK) to a first publisher and a second publisher of a plurality of publishers, the SDK enabling the first publisher and the second publisher to configure a plurality of tournaments for a title;
receive, by the system, a first tournament definition and one or more first permission levels for the title from the first publisher, according to the SDK, wherein the one or more first permission levels define which of a plurality of tournament organizers are able to create tournament definitions or view tournament instances for the title, wherein the one or more first permission levels further define parameters for the plurality of tournament organizers to follow when creating the plurality of tournaments for the title;
receive, by the system, a second tournament definition and one or more second permission levels for the title from the second publisher, according to the SDK, wherein the one or more second permission levels define which of the plurality of tournament organizers are able to create tournament definitions or view tournament instances for the title, wherein the one or more second permission levels further define parameters for the plurality of tournament organizers to follow when creating the plurality of tournaments for the title;
determine, by the system, whether at least one of the first tournament definition or the second tournament definition includes a declaration for publication of at least one of a first tournament or a second tournament of the plurality of tournaments within the title; and
publish the first tournament and the second tournament according to the tournament definition.

US Pat. No. 10,391,400

ELECTRONIC CONTROLLER WITH HAND RETAINER AND FINGER MOTION SENSING

Valve Corporation, Belle...

1. A controller for an electronic system, for operation by a user having a hand with fingers and a palm, the controller comprising:a controller body having a handle portion with an outside surface;
a tracking arc that is fixed to the controller body;
a hand retainer configured to physically bias the palm against the outside surface;
a first plurality of tracking sensors disposed in the tracking arc, the first plurality of tracking sensors being responsive to electromagnetic radiation emitted by the electronic system; and
an array of proximity sensors that are spatially distributed around the outside surface of the handle portion, the array of proximity sensors being responsive to a proximity of the fingers to the outside surface of the handle portion.

US Pat. No. 10,391,396

HAPTIC PERIPHERAL HAVING A HAPTICALLY-ENHANCED USER INPUT ELEMENT INCLUDING A MECHANICAL KEY AND AN INTEGRATED SMART MATERIAL ACTUATOR FOR PROVIDING HAPTIC EFFECTS

IMMERSION CORPORATION, S...

1. A haptic peripheral comprising:a housing; and
a haptically-enhanced user input element configured to receive an input, the haptically-enhanced user input element including
a mechanical key having a keycap, and
a smart material actuator integrated onto the keycap, wherein the smart material actuator is configured to receive a control signal from a processor and is configured to deform relative to the keycap of the mechanical key in response to the control signal from the processor to thereby provide a haptic effect to a user of the haptic peripheral, the haptic effect providing feedback relating to game state information.

US Pat. No. 10,391,394

SYSTEM AND METHOD FOR PROVIDING A SOFTWARE APPLICATION CONTROLLER

1. A system for providing a software application controller, the system comprising:a software application controller module, comprising computer-executable code stored in non-volatile memory;
a controller output module, comprising computer-executable code stored in non-volatile memory;
a processor;
one or more input device; and
one or more output device;wherein said software application controller module, said controller output module, and said processor, are operably connected and are configured to:receive input from one or more of said one or more input device;
connect to and transmit input data to said console based on said received input from said one or more input device;
receive output data from said console;
generate human perceptible output from said output data in one or more output device; and
transmit a switch signal to said console,wherein said switch signal provides for the swapping of control of said console from a first software application controller to a second software application controller thereby providing a hot-seat controller switch such that said console is agnostic with regard to which software application controller controls said console.

US Pat. No. 10,391,391

DEVICE FOR MANAGING OPERATIONS OF ACCESSORIES

STEELSERIES APS, Frederi...

1. An apparatus, comprising:a controller; and
a memory that stores executable instructions that, when executed by the controller, facilitate performance of operations comprising:
determining a user profile of a plurality of user profiles associated with a gaming accessory comprising a plurality of programmable layers; and
identifying a substitute accessory stimulation for a gaming accessory stimulation of the gaming accessory by way of a predetermined association of the gaming accessory stimulation with the substitute accessory stimulation of a programmable layer of the plurality of programmable layers,
wherein the predetermined association is recorded in the user profile of the plurality of user profiles, and
wherein other predetermined associations of stimulations of the gaming accessory with other substitute accessory stimulations are recorded in other user profiles of the plurality of user profiles.

US Pat. No. 10,391,390

METHOD FOR LOCKING TARGET IN GAME SCENARIO AND TERMINAL

TENCENT TECHNOLOGY (SHENZ...

1. A method for locking a target in a game application, the method comprising:at a terminal that has one or more processors and memory storing instructions executed by the processors:
obtaining, by the terminal, input gesture information from a user on an operation interface of a game application, wherein the game application includes multiple object categories, each object category having one or more virtual characters displayed on the operation interface;
recognizing, by the terminal, the gesture information to obtain a switching instruction of the game application corresponding to the gesture information;
selecting, by the terminal, an object category of virtual characters according to the switching instruction;
locking, by the terminal, a target virtual character in the object category according to a preset rule and performing, by the terminal, an operation on the target virtual character; and
after performing the operation, automatically repeating, by the terminal, the locking and the performing operations on a next target virtual character in the object category until finishing a last virtual character in the object category.

US Pat. No. 10,391,388

PROGRAM, METHOD, AND SYSTEM OF TRANSMITTING OR RECEIVING MESSAGE

GREE, INC., Tokyo (JP)

1. A non-transitory computer-readable medium with a program stored therein for executing a method comprising:receiving, by a controller, a message from a first user terminal of a plurality of user terminals belonging to a chat group;
outputting the message on a timeline view of each of the plurality of user terminals if the type of the received message is a normal message;
if the type of the received message is a selection of a game icon of a game in which a user plays a match against another user to determine a win-loss outcome, outputting an entry wait message to the game on at least a timeline view of each of the plurality of user terminals other than the first user terminal;
responsive to an entry received from a second user terminal of the plurality of user terminals, generating a game message according to a game logic corresponding to the game icon, and transmitting the generated game message to at least the first user terminal and the second user terminal;
waiting for an entry from the user terminals until an entry waiting ending condition corresponding to the game icon is satisfied;
determining a game result, which is the win-loss outcome in the game, based on the game message and the game logic and generating a game result message according to the game result; and
outputting the game result message on the timeline view of each of the plurality of user terminals.

US Pat. No. 10,391,381

ATHLETIC TRAINING SYSTEM AND METHOD

NIKE, Inc., Beaverton, O...

1. A method comprising:receiving data electronically recorded in a sporting event, wherein the data includes athletic performance metrics of an athlete participating in the sporting event;
processing the recorded sporting event data through a data engine;
generating a virtual replay of the sporting event using the recorded sporting event data, including:
generating an avatar of the athlete, wherein the avatar of the athlete is a virtual representation of the athlete;
adding the avatar into the virtual replay in a user-selectable manner, such that, when the virtual replay is rendered, the avatar of the athlete is user-selectable within the virtual replay; and
receiving a user selection of the avatar in the virtual replay to cause display of an athlete display portion during the virtual replay, the athlete display portion including one or more activity metrics of the athlete; and
displaying an athletic performance analysis based on the received athletic performance metrics, wherein the athletic performance analysis includes one or more suggested training programs for the athlete based on the received athletic performance metrics.

US Pat. No. 10,391,380

SYSTEMS AND METHODS FOR COORDINATING MUSCULOSKELETAL AND CARDIOVASCULAR OR CEREBROVASCULAR HEMODYNAMICS

Pulson, Inc., Palo Alto,...

1. A method for guiding a user towards a target rhythmic musculoskeletal activity cycle to cardiac cycle timing relationship, the method comprising:detecting a signal responsive to a cyclically-varying arterial blood flow at a location on a head of a user, the signal varying throughout each heart pump cycle of the user;
providing a recurrent prompt at a frequency of the heart pump cycle using the signal, wherein the signal correlates with a magnitude of the blood flow adjacent to the location of the signal, wherein the recurrent prompt is provided to guide the user to time performance of a component of a rhythmic musculoskeletal activity with the recurrent prompt; and
guiding the user to adjust a timing of the component of the rhythmic musculoskeletal activity to substantially maximize a magnitude of the signal.

US Pat. No. 10,391,379

TAKEOFF POINT MARKER ASSEMBLY

1. A takeoff point marker assembly, comprising:a planar member having a bottom surface and a top surface;
a plurality of spikes affixed to the bottom surface, wherein the plurality of spikes tapers away from the bottom surface of the planar member;
a distal end of the plurality of spikes defining a point, wherein the point is dimensioned to pierce a track;
a plurality of covers configured to house the plurality of spikes, wherein the plurality of covers is each removably securable to each of the plurality of spikes and wherein each cover of the plurality of covers is shaped to directly contour each spike of the plurality of spikes;
an indicia disposed on the top surface, the indicia configured to indicate a position on the track when engaged therewith.

US Pat. No. 10,391,376

STICKHANDLING TOOLS, HOCKEY TRAINING AIDS, AND RELATED METHODS

1. A stickhandling tool comprising:a hockey stick having a first hockey stick blade;
a second hockey stick blade;
a structural part comprising a first cross member and a second cross member that connect to the hockey stick and laterally separate the first hockey stick blade and the second hockey stick blade to define a ball or puck receiving cavity between the first hockey stick blade and the second hockey stick blade;
in which the structural part comprises a clamp, and the second cross member connects to the hockey stick by the clamp connecting the second cross member to a shaft of the hockey stick, a heel part of the first hockey stick blade, or an ankle part of the of the first hockey stick blade;
in which the structural part further comprises a toe receiving cup that receives, and connects the first cross member to, a toe part of the first hockey stick blade; and
in which the first cross member extends between respective toe parts of the first hockey stick blade and the second hockey stick blade, and the second cross member extends between respective heel or ankle parts of the first hockey stick blade and the second hockey stick blade.

US Pat. No. 10,391,372

GOLF GRIP

EATON INTELLIGENT POWER L...

1. A golf grip, comprising:an elongated tubular body having an exterior surface, an interior surface, a butt end, a tip end, a length from the butt end to the tip end, and the golf grip has an overall density;
wherein a point along the length has a cross-section having a cross-sectional area, an exterior cross-sectional radius having a minimum exterior cross-sectional radius, and an interior surface radius having a minimum interior surface radius;
wherein the cross-section includes a first region, and a second region, the first region extending outward from the interior surface a first region thickness that is constant around interior surface, and thereby defining the second region as the balance of the cross-section between the exterior surface and the first region, wherein the first region thickness is equal to one-half of a difference between the minimum exterior cross-sectional radius and the minimum interior surface radius;
wherein a first region average density is determined for a first region test volume bounded by the interior surface, the second region, the cross-section, and an offset cross-section that is parallel to the cross-section and 1 cm away from the cross-section;
wherein a second region average density is determined for a second region test volume bounded by the exterior surface, the first region, the cross-section, and the offset cross-section;
wherein the first region average density is less than the second region average density; and
wherein the elongated tubular body is formed of at least a first inner layer containing a first layer quantity of blowing agent, having a first layer thickness and a first layer density, and a second outer layer containing a second layer quantity of blowing agent different than the first quantity of blowing agent, having second layer thickness and a second layer density, wherein the first layer density is different than the second layer density, wherein the first inner layer and the second outer layer consist of rubber compounds cross-linked together under heat and pressure.

US Pat. No. 10,391,371

GOLF CLUB HAVING REMOVEABLE WEIGHT

Acushnet Company, Fairha...

1. A golf club head, comprising:a hosel;
a ball striking face;
a sole extending aftward from a lower edge of said ball striking face;
a crown extending aftward from an upper edge of said ball striking face;
a skirt extending between said sole and said crown;
a weight mount including a recess, wherein said weight mount is disposed on at least one of said sole, said crown and said skirt;
a weight member located in said recess;
a retainer spanning said recess, said retainer configured to retain said weight member in said recess;
wherein said weight mount comprises a bevel configured to receive a portion of said retainer;
wherein said retainer comprises an angled abutment surface at a first end of said retainer configured to engage said bevel;
wherein said weight mount comprises a fastener receptacle;
wherein said retainer comprises a weight bore at a second end of said retainer configured to receive said fastener; and
a fastener configured to pass through said weight bore of said retainer and engage said fastener receptacle;
wherein said retainer comprises a tapered portion configured to engage a head of said fastener;
wherein said head of said fastener includes a tapered engagement portion;
wherein installation of said fastener to force said retainer against said weight mount causes said tapered engagement portion of said fastener to engage said tapered portion of said retainer, simultaneously forcing said second end of said retainer against said weight mount and said angled abutment surface at said first end of said retainer into said bevel of said weight mount, said bevel of said weight mount engaging said angled abutment surface of said retainer and forcing said first end of said retainer against said weight mount.

US Pat. No. 10,391,370

CO-FORGED GOLF CLUB HEAD AND METHOD OF MANUFACTURE

Acushnet Company, Fairha...

11. A forged golf club head comprising:a body portion made out of a first metallic material having a face cavity and at least one weight cavity;
at least one high density weight adjustment portion made out of a second metallic material encased within said weight cavity;
a lightweight weight adjustment portion made out of a third metallic material encased within said face cavity; and
a striking face insert made out of said first material adapted to cover a frontal portion of said body portion,
wherein said striking face insert at least partially forms a portion of a topline and a portion of a sole portion of said forged golf club head,
wherein said lightweight weight adjustment portion substantially covers an entire frontal surface of said face cavity,
wherein said lightweight weight adjustment portion further comprises a plurality of two or more cutouts, said plurality of cutouts form a draft angle to create a countersink, and
wherein said high density weight adjustment portion is encased monolithically within said weight cavity.

US Pat. No. 10,391,368

GOLF CLUB WITH MOVABLE WEIGHT

Acushnet Company, Fairha...

1. A golf club head, comprising:a body having a face, a sole, a crown, and a skirt joining said face, sole, and crown;
a hollow golf club interior within said body;
said body having an exterior surface opposite said hollow golf club interior;
said body having a center of gravity;
wherein said body comprises an elongate weight receptacle;
a weight retainer located in said weight receptacle;
wherein said weight receptacle comprises a plurality of weight mounts;
wherein said weight retainer comprises a rotating portion and a non-rotating portion, said rotating portion rotatably affixed to said non-rotating portion;
wherein between 180 degrees and 10 degrees of rotation of said rotating portion in a first direction relative to said non-rotating portion locks said weight retainer, and wherein between 180 degrees and 10 degrees of rotation of said rotating portion in a second direction relative to said non-rotating portion unlocks said weight retainer; and
wherein said weight retainer is configured to slide along said weight receptacle between each of said plurality of weight mounts when said weight retainer is unlocked, and wherein said weight retainer is configured to reside in any of said plurality of weight mounts when said weight retainer is locked;
wherein said weight receptacle comprises a pair of locking rails running along each side of said weight receptacle and a channel formed between said locking rails;
wherein each of said plurality of weight mounts comprises a recess, and wherein said recess comprises a locking wall, wherein said pair of locking rails comprise thick portions and thin portions, said thin portions located adjacent said recesses, and wherein said locking walls are formed between said thin portions and said thick portions.

US Pat. No. 10,391,366

AERODYNAMIC GOLF CLUB HEAD

TAYLOR MADE GOLF COMPANY,...

1. An aerodynamic golf club head comprising:A) a hollow body having a club head volume of at least 440 cc, a face, a sole section, a crown section, a front, a back, a heel, and a toe, wherein the hollow body has a front-to-back dimension of at least 4.4 inches and a second moment of inertia (MOIx) about a horizontal axis through the center of gravity that is at least 2000 g*cm2;
B) the face having a top edge and a lower edge, wherein a top edge height is the elevation of the top edge above the ground plane, and a maximum top edge height is at least 2 inches; and
C) the crown section having a crown apex located an apex height above a ground plane and having an apex ratio of the apex height to the maximum top edge height of at least 1.13, wherein:
(i) within a front-to-back vertical section through the crown apex and perpendicular to a vertical plane created by a shaft axis, a portion of the crown section between the crown apex and the face has an apex-to-front radius of curvature, and a portion of the crown section between the crown apex and the back of the hollow body has an apex-to-rear radius of curvature,
(ii) within a heel-to-toe vertical section through the crown apex and parallel to the vertical plane created by the shaft axis, a portion of the crown section above the top edge height has a heel-to-toe radius of curvature; and
(iii) a majority portion of the crown section is composed of a nonmetallic material having a density less than a portion of the sole section, and a portion of the crown section has at least two of (a) the heel-to-toe radius of curvature in contact with the crown apex that is less than 4 inches, (b) the apex-to-rear radius of curvature that is greater than 5 inches on a portion of the crown section above the top edge height that is composed of the nonmetallic material, and (c) the apex-to-front radius of curvature in contact with the crown apex is at least 25% less than a portion of the apex-to-rear radius of curvature located above the top edge height.

US Pat. No. 10,391,361

SIMULATING REAL-WORLD TERRAIN ON AN EXERCISE DEVICE

1. A system comprising:a receiving module for receiving location data associating video frames depicting a real-world route with a topographical location of the real-world route, the video frames having been captured by a video-capturing device while traversing the real-world route; and
a conversion module for creating an exercise program comprising:
control signals representing changes to be made to one or more operating parameters of an exercise device as the video frames depicting the real-world route are displayed to a user of the exercise device, the control signals based at least in part on the location data, and the changes to the one or more operating parameters corresponding at least in part to one or more aspects of the real-world route; and
an icon overlaying the video frames and depicted as being located on the real-world route depicted in the video frames as captured by the video-capturing device while traversing the real-world route.

US Pat. No. 10,391,357

HEIGHT ADJUSTABLE AEROBIC STEP

1. A height-adjustable aerobic step comprising a rectangular step platform with two opposite ends in a length direction thereof and two supporting legs, each of the two supporting legs extending downwardly respectively from a bottom surface of each of the two opposite ends,wherein a lower half of each of the two supporting legs are disposed with a first positioning portion having two parallel first lateral plates with a side of each of the two parallel first lateral plates being disposed with two first seizure portions, an upper half of each of two extending legs is disposed with a second positioning portion pivotally connecting to the first positioning portion of each of the two supporting legs for each of the two extending legs configured to be folded inwardly relative to the two supporting legs such that a bottom surface of the two supporting legs are at a top surface of the two extending legs when the two supporting legs and the two extending legs are unfolded into a straight line, the second positioning portion has two parallel second lateral plates which are respectively corresponding to and placed adjacent to the two parallel first lateral plates, and a side of each of the two parallel second lateral plates is disposed with two second seizure portions for corresponding to the two first seizure portion and limiting a position of the two first seizure portion; and
wherein the two parallel first lateral plates and the two parallel second lateral plates are bendable and flexible, so as to allow one of the second lateral plate to slide on a corresponding one of the first lateral plates.

US Pat. No. 10,391,355

FUNCTIONAL TRAINING EQUIPMENT WITH MULTIPLE MOVEMENT PLANES FOR BACK EXERCISES

1. An overhead pull machine comprising:a resistance element;
a user support coupled to the resistance element;
a first movement element disposed below and coupled to the user support, the first movement element comprising:
a horizontally oriented rail; and
a first carriage coupled to the user support and movably coupled to the rail such that the first carriage is able to move along a linear path defined by the rail; and
a second movement element disposed forward of the user support, the second movement element comprising:
an inclined column; and
a second carriage coupled to a forward extension of the user support and movably coupled to the column such that the second carriage is able to move along the column.

US Pat. No. 10,391,342

FIRE PROTECTION UNIT

Tyco Fire Products LP, L...

1. A fire protection unit comprising:an actuator;
a fire detector to signal operation of the actuator;
a fixed volume supply of compressed gas defining an internal pressure and supply duration, the supply being coupled to the actuator for controlled release of the compressed gas;
a fixed volume source of firefighting agent coupled to the fixed volume supply of compressed gas; and
a manifold coupled to and downstream of the fixed volume source of firefighting agent for dispersing the firefighting agent, the manifold defining a linear longitudinal axis downstream of the fixed volume source of firefighting agent, an internal passageway and a plurality of openings in fluid communication with the internal passageway and spaced apart along the manifold for distribution of the firefighting agent upon the operation of the actuator to release the compressed gas supply and pressurize the manifold with the agent along the internal passageway of the manifold, the actuator axially aligned with the manifold along the longitudinal axis, the fixed volume supply of compressed gas and the fixed volume source of firefighting agent axially aligned with the manifold along the longitudinal axis.

US Pat. No. 10,391,341

EXTINGUISHING METHOD AND EXTINGUISHING DEVICE FOR INTRODUCING AT LEAST ONE EXTINGUISHING AGENT INTO A BATTERY

AUDI AG, Ingolstadt (DE)...

1. A method for introducing at least one extinguishing agent into a battery, comprising:introducing the at least one extinguishing agent into a housing of the battery, which is at least partially sealed against the penetration of water and in which are arranged a plurality of battery cells,
creating a through-opening in a partial region of a wall of the housing by piercing the wall of the housing with a lance of an extinguishing device; and,
introducing the at least one extinguishing agent into the housing of the battery through a supply channel of the extinguishing device,
wherein the battery further comprises a pressure compensation element arranged in the through-opening in the wall of the housing, and
wherein the pressure compensation element comprises:
a membrane configured to be destroyed by piercing of the lance;
a circumferential seal configured to be provided on at least one side of the pressure compensation element facing at least one outer side of the wall of the housing; and
a bayonet cover configured to be provided on the pressure compensation element so that the pressure compensation element attached on the wall of the housing.

US Pat. No. 10,391,338

SLEEVE-FIT RESPIRATOR CARTRIDGE

3M Innovative Properties ...

1. A respirator apparatus, comprising:a respirator body;
a filter cartridge receiver integral with and extending from the respirator body; and
a filter cartridge comprising a nozzle element integral with the filter cartridge; wherein the respirator body and filter cartridge are configured to be fluidically coupled through sleeve-fit engagement between the filter cartridge receiver and nozzle element and the filter cartridge receiver and nozzle element define an airflow channel,
wherein the filter cartridge receiver comprises a first alignment feature and the nozzle element comprises a second alignment feature and the first alignment feature cooperates with the second alignment feature to register the nozzle element to the filter cartridge receiver, and wherein the first alignment feature and the second alignment feature is an elongated protrusion that is parallel with a direction of the sleeve-fit engagement.

US Pat. No. 10,391,337

RESPIRATOR ASSEMBLY WITH AIR FLOW DIRECTION CONTROL

3M Innovative Properties ...

1. A respirator assembly comprising:a protective shell shaped to cover at least a portion of a user's head and define a breathable air space, wherein the protective shell comprises a visor through which the user can see while the protective shell is worn by the user;
an air inlet conduit;
a top air delivery conduit in fluid communication with the air inlet conduit and having a top outlet at a terminal end of the top air delivery conduit, wherein the top outlet is configured to be adjacent a Forehead area of the user when the protective she is worn by the user, wherein the top air delivery conduit is configured to deliver air to the breathable air space defined within the protective shell;
a side air delivery conduit in fluid communication with the air inlet conduit and having an upper portion, a lower portion, and an elbow portion, wherein the lower portion of the side air delivery conduit defines a side outlet configured to deliver a flow of air into the breathable air space, wherein the elbow portion is flexible and allows movement of the lower portion relative to the upper portion to adjust the side outlet between a first outlet configuration wherein the air flow from the side outlet is directed in a first direction and a second outlet configuration wherein the air flow from the side outlet is directed in a second, different direction, and wherein the side outlet is moveable between its first and second outlet configurations while the protective shell is worn by the user; and
a manipulatable element outside the protective shell, wherein the manipulatable element is configured to move the lower portion of the side air delivery conduit to move the side outlet between its first and second outlet configurations.

US Pat. No. 10,391,333

TREATMENT APPARATUS USING PROTON AND ULTRASOUND AND METHOD OF TREATING CANCER USING THE SAME

ELECTRONICS AND TELECOMMU...

1. A treatment apparatus using proton and ultrasound, the treatment apparatus comprising:a proton generator configured to emit a proton beam to a tumor of a body;
an ultrasound generator configured to emit an ultrasonic beam to the tumor in a direction crossing an emission path of the proton beam; and
a sensor configured to measure an acoustic signal generated during the emission of the proton beam,
wherein the proton beam is configured to emit so that the proton beam has a stop location within the tumor, and
wherein the ultrasonic beam is configured to emit so that the ultrasonic beam has a focal zone overlapping the stop location.

US Pat. No. 10,391,328

MULTI-WAVE SIGNAL KEEP-FIT ENERGY CHAMBER

1. A multi-wave signal keep-fit energy chamber, comprising a chamber shell, a middle squirrel-cage chamber framework, chamber opening/closing doors and multi-wave signal emission elements, wherein:the multi-wave signal emission elements comprise a multi-wave signal emission element bracket, heating coils, a high-voltage electric field, a multi-wave signal modulation power supply, a multi-wave signal waveguide cover and a multi-wave signal emission element base;
the heating coils are uniformly coiled on the multi-wave signal emission element bracket and used for heating the multi-wave signal emission elements;
a top of the multi-wave signal emission element bracket is connected with the multi-wave signal waveguide cover;
a bolt is connected with the top of the multi-wave signal emission element bracket from a top of the multi-wave signal waveguide cover to the multi-wave signal emission element base at bottoms of the multi-wave signal emission elements;
the multi-wave signal emission element base is electrically connected with a high-voltage positive pole;
the bolt is electrically connected with a high-voltage negative pole;
a layer of multi-wave signal modulation power supply coils or metal bodies is coiled on an outer wall of the multi-wave signal emission element base to serve as a carrier of multi-wave signal charge of the multi-wave signal modulation power supply;
the chamber opening/closing doors are arranged at front and rear parts of the middle squirrel-cage chamber framework;
an exterior of the middle squirrel-cage chamber framework is coated by the chamber shell, and an interior of the middle squirrel-cage chamber framework is filled with porous liners;
a number of 90-150 of the multi-wave signal emission elements are uniformly distributed on the middle squirrel-cage chamber framework;
a first ventilating fan, a second ventilating fan and lighting equipment are arranged in the chamber; and
a circuit control system of the multi-wave signal emission elements is adapted to monitor operations of the heating coils of each of the multi-wave signal emission elements, the high-voltage electric field and the multi-wave signal modulation power supply by virtue of a software control program, and the circuit control system is further adapted to monitor and control temperature change in the energy chamber.

US Pat. No. 10,391,326

PORTABLE DEFIBRILLATOR USED FOR DISPLAY, HARDCOPY, AND CONTROL FOR OTHER DEVICES

ZOLL Medical Corporation,...

1. A shared resource medical system, comprising:a primary device comprising a portable defibrillator, the portable defibrillator including one or more sensors to measure defibrillator information for a patient; and
a secondary device communicatively coupled with the primary device, the secondary device comprising:
a display screen,
an ultrasound transducer configured to obtain physiological data for a patient and to transmit the obtained physiological data, and
at least one processor in communication with the primary device, the display screen, and the ultrasound transducer, wherein the at least one processor is configured to:
receive and process information from the primary device,
receive and process the obtained physiological data transmitted from the ultrasound transducer to generate an ultrasound image, and
control the display screen to display a visual representation of the ultrasound image and the received information from the primary device.

US Pat. No. 10,391,325

ELECTRODE DESIGNS IN IMPLANTABLE DEFIBRILLATOR SYSTEMS

CARDIAC PACEMAKERS, INC.,...

1. An implantable defibrillator comprising:a canister housing a source of electrical energy, a capacitor, and operational circuitry that senses heart rhythms; and
an electrode and lead assembly, the electrode and lead assembly comprising:
a lead with a proximal end adapted for attachment to the canister and a distal end;
at least one sensing electrode on the lead; and
at least one shocking electrode on the lead;
wherein the at least one shocking electrode extends over a length in the range of 50 to 110 millimeters and a width in the range of 5 to 35 millimeters; and
wherein the at least one sensing electrode is distal to the at least one shocking electrode.

US Pat. No. 10,391,324

SELECTABLE BOOST CONVERTER AND CHARGE PUMP FOR COMPLIANCE VOLTAGE GENERATION IN AN IMPLANTABLE STIMULATOR DEVICE

Boston Scientific Neuromo...

1. A medical device, comprising:electrodes configured to stimulate a patient's tissue;
a first converter circuit configured to convert a first voltage to a compliance voltage when enabled; and
a second converter circuit configured to convert the first voltage to the compliance voltage when enabled,
wherein the first converter circuit and second converter circuit are not configured to be simultaneously enabled, and
wherein the compliance voltage is configured to provide power for the electrodes to provide stimulation at the patient's tissue.

US Pat. No. 10,391,322

TIMING CHANNEL CIRCUITRY FOR CREATING PULSES IN AN IMPLANTABLE STIMULATOR DEVICE

Boston Scientific Neuromo...

1. An implantable stimulator device, comprising:a plurality of electrodes configured to provide stimulation to a patient's tissue;
a memory configured to store pulse parameters for a periodic pulse, wherein each pulse comprises a plurality of sequential pulse phases, wherein at least one pulse phase with a first duration comprises a plurality of sequential sub-phases, wherein the at least one pulse phase has an amplitude that is not constant,
wherein data stored in the memory for each sub-phase of the at least one pulse phase comprises at least:
an amplitude of the sub-phase, wherein the amplitudes of the sub-phases are not all equal,
a second duration of the sub-phase less than the first duration, and
a positive or negative polarity of the amplitude that each one of the plurality of electrodes is to receive, and
a percentage of the amplitude that each one of the plurality of electrodes is to receive;
stimulation circuitry electrically coupled to the plurality of electrodes comprising first Digital-to-Analog Converter (DAC) circuitry configured to provide a positive current and second DAC circuitry configured to provide a negative current; and
control circuitry configured to sequentially receive the second duration for each sequential sub-phase from the memory, wherein the control circuitry is configured to sequentially provide the data for each sequential sub-phase to the stimulation circuitry in accordance with the second durations to allow the stimulation circuitry to form the non-constant amplitude pulse phase,
wherein the first DAC circuitry is configured to provide the positive current to electrodes having a positive polarity and with an amplitude in accordance with their percentages, and wherein the second DAC circuitry is configured to provide the negative current to electrodes having a negative polarity and with an amplitude in accordance with their percentages,
wherein if the positive current is to be provided to more than one electrode having a positive polarity, the stored percentage of the amplitude for each such more than one electrode is less than 100 percent, and
wherein if the negative current is to be provided to more than one electrode having a negative polarity, the stored percentage of the amplitude for each such more than one electrode is less than 100 percent.

US Pat. No. 10,391,320

TECHNIQUES FOR DETECTING MAGNETIC RESONANCE IMAGING FIELD

Medtronic, Inc., Minneap...

21. A system comprising:an implantable medical device (IMD);
a first magnetic field sensor connected to the IMD and configured to measure a first strength of a static magnetic field at a first location;
a second magnetic field sensor connected to the IMD and configured to measure a second strength of the static magnetic field at a second location; and
a processor configured to determine that at least one of the first and second strengths is greater than a lower threshold value and, in response to determining that at least one of the first and second strengths is greater than the lower threshold value determine a difference between the first strength and the second strength and to identify a source of the static magnetic field based on the difference between the first and second strengths.

US Pat. No. 10,391,316

SYSTEM AND METHOD FOR PACING PARAMETER OPTIMIZATION USING HEART SOUNDS

Medtronic, Inc., Minneap...

1. A method comprisingdelivering, by a medical device system, pacing pulses at varying pacing settings;
obtaining, by the medical device system, heart sound signals from an acoustical sensor;
determining, by the medical device system and based on the heart sound signals, a plurality of heart sound signal parameters;
determining, by the medical device system and based on the heart sound signal parameters, a relative change of a V-S2 interval, wherein the V-S2 interval is a time interval between a ventricular electrical event and an S2 heart sound, and wherein the relative change of the V-S2 interval is responsive to the varying pacing settings;
identifying, by the medical device system and based on the relative change of the V-S2 interval, a target pacing parameter; and
delivering, by the medical device system, pacing pulses according to the target pacing parameter.

US Pat. No. 10,391,315

NEUROMODULATION WITH BURST STIMULATION

Boston Scientific Neuromo...

1. A non-transitory machine-readable medium including instructions, which when executed by a machine operably connected to electrodes positioned proximate to dorsal horn tissue or nerve root tissue, cause the machine to:modulate the dorsal horn tissue or the nerve root tissue by delivering modulation energy using the electrodes to promote a uniform modulation field along a span of a lead where the span includes at least two of the electrodes, wherein the delivered modulation energy includes pulse trains of at least two pulses, and wherein the uniform modulation field includes a constant E field, a constant |E| field or a constant V field in the dorsal horn tissue or the nerve root tissue along the span of the lead.

US Pat. No. 10,391,313

SYSTEMS AND METHODS FOR THE DEVELOPMENT OF THERAPY PARADIGMS FOR NEUROLOGICAL TREATMENTS

BOSTON SCIENTIFIC NEUROMO...

1. A neuromodulation device configured for use with one or more electrodes for delivery of neuromodulation signals, and having operational circuitry including therapy delivery circuitry controllable by the operational circuitry, wherein the operational circuitry is configured to control the therapy delivery circuitry to have at least the following therapeutic outputs programmed:a first therapy pattern configured to accomplish a first effect on a patient;
a second therapy pattern configured to accomplish a second effect on a patient;
wherein the operational circuitry is configured to output the first therapy pattern and the second therapy pattern using a plurality of the electrodes such that the first effect impacts the second effect; and
wherein the first and second patterns are different from one another insofar as the first therapy pattern is an asymmetric voltage controlled output, and the second therapy pattern is an assymetric current controlled output.

US Pat. No. 10,391,302

DEVICE FOR ELECTRICAL STIMULATION OF PERIDONTAL COMPLEX AND SURROUNDING TISSUE

1. A device for electrical stimulation of one or more components of a periodontal complex and surrounding tissue of a tooth, comprising:at least two electrodes, comprising at least a first electrode of a rigid, electrically conductive material and a second electrode of a rigid, electrically conductive material, wherein the first electrode and the second electrode are in a fixed spatial relationship such that a distance between an end of the first electrode and an end of the second electrode permits application of the first and second electrodes to oral mucosa and attached gingiva adjacent to, and along a periodontal ligament of, a root structure of a single tooth;
an electrical circuit electrically connected to the the first and second electrodes, the electrical circuit having an output providing an electrical stimulus comprising a waveform in accordance with predetermined stimulation parameters, wherein the electrical circuit, when activated when the first and second electrodes are applied to the oral mucosa and attached gingiva adjacent to, and along the periodontal ligament of, the root structure of the single tooth, outputs the electrical stimulus through the first and second electrodes.

US Pat. No. 10,391,301

ARCHITECTURES FOR MULTI-ELECTRODE IMPLANTABLE STIMULATOR DEVICES HAVING MINIMAL NUMBERS OF DECOUPLING CAPACITORS

Boston Scientific Neuromo...

1. An implantable medical device, comprising:an electrode array comprising a plurality of electrodes;
a first current path coupleable to a first of the plurality of electrodes, wherein the first current path comprises an anode or cathode current path;
a plurality of second current paths each coupleable to a different second of the plurality of electrodes, wherein each of the second current paths comprises the other of an anode or cathode current path when compared to the first current path,
at least one current source configured to provide a current in one of the second current paths;
wherein the first current path and the second current paths together comprise X current paths; and
a plurality of X?1 capacitors, wherein one of the X?1 capacitors is placed in one of the X current paths such that only one of the X current paths does not include a capacitor.

US Pat. No. 10,391,300

COLLAPSING COIL COUPLING FOR LEAD EXTENSION AND EXTRACTION

THE SPECTRANETICS CORPORA...

1. A device for extending a lead, comprising:a body;
a coil element coupled to the body, the body configured to cover at least a portion of the coil element during use, the coil element comprising a plurality of coils forming an inner lumen, wherein the inner lumen is sized to receive an outer surface of a lead, the coil element is movable between a first configuration in which the coil element slides over the lead, and a second configuration in which at least some coils of the plurality of coils grip the outer surface of the lead; and
an actuation mechanism operatively coupled to the coil element, the actuation mechanism configured to move the coil element between the first and second configurations.

US Pat. No. 10,391,296

MATRIX-CODED AED MAINTENANCE

Physio-Control, Inc., Re...

1. A medical device, comprising:a plurality of operable components, each of the operable components having a current status associated therewith, the operable components including at least a battery and a defibrillator electrode;
a processor configured to initiate a self-test of at least one of the plurality of operable components and determine a current operational status of the medical device and a current status of the at least one of the plurality of operable components based on the self-test;
a code generation component configured to automatically generate a matrix code based on the determined current operational status of the medical device and the current status of the at least one of the plurality of operable components, the matrix code encoding the current operational status of the medical device and the current status of the at least one of the plurality of operable components and the matrix code further including a non-encoded, visually interpretable indicator of the operational status of the medical device; and
a display screen configured to display the matrix code that includes status information, the status information including at least the current operational status of the medical device and the current status of at least one of the plurality of operable components.

US Pat. No. 10,391,295

DISINFECTION CAP FOR IV NEEDLELESS CONNECTORS

Becton, Dickinson and Com...

7. A cap comprising:a multiple start thread pattern comprising
a first start thread path wherein the first start thread path has a first major profile, a first minor profile, a first pitch, and a first thread section profile, and
at least a second start thread path wherein the second start thread path has a second major profile, a second minor profile, a second pitch, and a second thread section profile; and
an inner cavity comprising an inner surface having said first and second start thread paths, a closed end, and an open end opposite said closed end comprising an opening configured to receive a secondary medical device connector,
wherein
the first thread section profile and the second thread section profile are different,
the first pitch and the second pitch are substantially equivalent,
the first and second start thread paths are configured to interface with a complimentary male thread of said secondary medical device connector, said complimentary male thread having a third major profile with a uniform outer diameter, a third minor profile, and a third pitch substantially equivalent to the first and second pitches of the first and second start thread paths, and
when said complimentary thread is engaged to said first and second start thread paths contacting said third major profile a first helical void is formed by the space enclosed by at least one of said third major profile and said third minor profile of the complimentary male thread and the first start thread path and a second helical void is formed by the space enclosed by at least one of said third major profile and said third minor profile of the complimentary male thread and the second start thread path, wherein said second helical void is larger than the first helical void, and
an airflow path from a proximal end of the cap to the inner cavity is formed by said first and second helical voids when said complimentary male thread is engaged to said multiple start thread pattern.

US Pat. No. 10,391,291

IMPLANT INSERTION SYSTEM

1. An apparatus comprising:a needle shell having an axial end adapted to be inserted below a surface of tissue that is to receive an implant and an opposite end opposite the axial end, the axial end having an axial opening;
a removable implant tube slidable within the needle shell while the needle shell is adapted to be below the surface of the tissue that is to receive the implant, the removable implant tube having interior surfaces that are to contact and guide sliding movement of the implant that is to be contained within the removable implant tube; and
an implant insertion rod within the removable implant tube, wherein the removable implant tube is capable of sliding within the needle shell relative to the needle shell while the needle shell is adapted to be retained below the surface of the tissue that is to receive the implant and wherein the removable implant tube is configured to be slidable within the needle shell to a depth below the surface of the tissue such that an entire length of the implant is configured to be movable through the axial opening so as to be located below the surface of the tissue that is to receive the implant while the implant is contained and circumferentially surrounded by both the needle shell and the removable implant tube, wherein the removable implant tube is configured to be slidable within the needle shell to a position below a surface of skin and wherein the removable implant tube extends from the axial end to the opposite end, the removable implant tube providing an imperforate lumen from the axial end to the opposite end through the axial opening of the needle shell at the opposite end and through which fluid may be directed.

US Pat. No. 10,391,290

MICRONEEDLE INJECTION APPARATUS COMPRISING A DUAL COVER

3M Innovative Properties ...

1. A method of actuating a microneedle injection apparatus, the microneedle injection apparatus comprising:a housing having a base and a cavity that extends through the base to define an opening in the base, wherein the base of the housing is configured to be positioned toward a skin surface;
a microneedle array comprising a first side comprising a plurality of microneedles;
a microneedle array holder configured to hold a microneedle array and located in the housing, the microneedle array holder movable with respect to the opening in the base of the housing between
a retracted position in which the microneedle array is recessed within the housing such that the microneedle array does not contact the skin surface when the apparatus is positioned on the skin surface and the microneedle array is coupled to the microneedle array holder, and
an extended position in which at least a portion of the microneedle array is positioned to contact the skin surface via the opening when the apparatus is positioned on the skin surface and the microneedle array is coupled to the microneedle array holder; a
a cover configured to be positioned to cover the opening in the base of the housing, the cover including
a first portion configured to cover at least a portion of the base of the housing adjacent the opening, and
a second portion configured to be received in the cavity of the housing and further configured to cover the plurality of microneedles on the microneedle array when the microneedle array holder is in the retracted position; and wherein the microneedle applicator further includes an actuator movable with respect to the housing between a first position and a second position to cause the microneedle array holder to move from the retracted position to the extended position, wherein, at least when the actuator is in the first position, at least a portion of the actuator protrudes from the opening in the base of the housing and defines a base configured to be coupled to the skin surface, and wherein the cover is configured to cover at least the base of the actuator, wherein the cover is removable from the remainder of the apparatus, and wherein when the cover is coupled to the apparatus, the cover is positioned to prevent the actuator from being moved to its second position;
the method comprising actuating the actuator to move the actuator from the first position to the second position and to move the microneedle array holder from the retracted position to the extended position.

US Pat. No. 10,391,287

SHUNT CATHETER SYSTEM

University of South Flori...

1. A shunt catheter system for drainage of a fluid, comprising:a ventricular catheter having a proximal portion, a distal portion, and a longitudinal extent therebetween, wherein said distal portion of said ventricular catheter terminates at an open distal end such that an interior of said ventricular catheter is in open communication with an external environment of said ventricular catheter through said open distal end;
a reservoir detachably coupled to said proximal portion of said ventricular catheter, such that said interior of said ventricular catheter is in fluid communication with an interior of said reservoir;
a peritoneal catheter having a proximal end, a distal end, and a longitudinal extent therebetween, wherein said proximal end of said peritoneal catheter is coupled to said reservoir; and
an occluding component extendable through said longitudinal extent of said ventricular catheter for occluding said open distal end of said distal portion of said ventricular catheter during insertion of said ventricular catheter, said occluding component being a wire and plug assembly having a proximal end and a rounded distal plug, said wire and plug assembly including a wire extending proximally from said rounded distal plug;
said wire and plug assembly including a safety clip for preventing said rounded distal plug from being disposed excessively beyond said open distal end of said ventricular catheter, such that said proximal end of said wire and plug assembly is disposed external to said ventricular catheter and said rounded distal plug of said wire and plug assembly occludes said open distal end of said ventricular catheter
whereby said fluid follows a path of travel through said open distal end of said ventricular catheter, through said ventricular catheter, into said reservoir, and into said peritoneal catheter prior to being flushed out when said ventricular catheter is coupled to said reservoir.

US Pat. No. 10,391,284

BALLOON COATING METHOD, BALLOON ROTATING METHOD AND BALLOON COATING APPARATUS

TERUMO KABUSHIKI KAISHA, ...

1. A balloon coating method for forming a coating layer containing a drug on an outer surface of a balloon of a balloon catheter, the balloon coating method comprising:fixing a connection portion between the balloon and an inner tube passing through an inside of the balloon;
pulling the balloon in an axial direction of the balloon by the connection portion to thereby straighten a bend of the balloon; and
moving a dispensing tube relative to the balloon in an axial direction of the balloon while rotating the balloon about an axis of the balloon and dispensing the coating liquid containing the drug from the dispensing tube to apply the coating liquid to the outer surface of the balloon.

US Pat. No. 10,391,283

BALLOON CATHETER AND STENT DELIVERY SYSTEM

TERUMO KABUSHIKI KAISHA, ...

1. A balloon catheter comprising:a shaft portion of which an axially orthogonal cross section of an outer peripheral surface has a polygonal shape;
a balloon which is folded around the outer peripheral surface of the shaft portion and in which turned-back portions are formed, and wherein the turned-back portions include outer turned-back portions which are turned back to be convex in a radially outer direction and inner turned-back portions which are turned back to be convex in a radially inner direction, and wherein at least a portion of the balloon is arranged between a lower portion of the outer turned-back portions and an upper portion of the inner turned-back portions;
wherein portions formed to linearly extend along an axial direction in the turned-back portions are respectively positioned on sides of the polygonal shape;
wherein the outer turned-back portions and the inner turned-back portions are arranged to be alternately disposed in the circumferential direction so as not to overlap with each other when in a folded state, and wherein each of the sides of the polygonal shape has at least one of the outer turned-back portions or the inner turned-back portions; and
the turned-back portions being disposed on a side of the outer peripheral surface of the polygonal shape of the shaft portion.

US Pat. No. 10,391,274

MEDICAL DEVICE WITH DISTAL TORQUE CONTROL

1. A medical device comprising:a tube comprising a lumen and a longitudinal axis;
a longitudinal displacer configured to be moved relative to the tube, the longitudinal displacer being configured to transmit a longitudinal force to the tube when the longitudinal displacer is moved relative to the tube;
a cut along a distal end of the tube, wherein the cut comprises a helical or a spiral cut; and
a handle, wherein a proximal end of the tube is secured to the handle;
wherein a distal end of the tube is curved or angled relative to the longitudinal axis of the tube; and
wherein the tube is configured to rotate about the longitudinal axis of the tube when a longitudinal force is transmitted to the tube by the longitudinal displacer when the longitudinal displacer is moved relative to the tube.

US Pat. No. 10,391,271

APPARATUS FOR PERFORMING A CRICOTHYROTOMY/TRACHEOTOMY AND METHOD THEREFOR

1. A device for performing a cricothyrotomy and/or a tracheotomy comprising:an outer cannula;
an inner cutting cannula positioned within the outer cannula;
an actuator coupled to a proximate end of the inner cutting cannula, the actuator keeping the inner cutting cannula in a retracted position within the outer cannula, a distal end of the inner cutting cannula extending out of the outer cannula with a force to allow for the distal end of the inner cutting cannula to penetrate one of a cricothyroid membrane or tracheal wall when the actuator is activated;
a disarticulating needle catheter positioned at a distal end of the outer cannula wherein the disarticulating needle catheter comprises:
a needle; and
an outer catheter housing the needle, the outer catheter having a disarticulating head that opens to allow the inner cutting cannula within the outer catheter when the needle is removed.

US Pat. No. 10,391,269

NASAL SPRAYER WITH MULTIPLE APPLICATORS

1. A nasal sprayer, comprising:a receptacle for receiving a volume of a liquid medicament, the receptacle having an open upper end;
a cap for releasably covering and sealing the open upper end of the receptacle;
a dispensing assembly comprising:
a housing;
a central channel formed through the housing;
first and second ports in fluid communication with the central channel and extending through the housing; and
a rotating valve for selectively sealing one of the first and second ports and simultaneously opening the other one of the first and second ports, wherein the rotating valve includes a shaft, the shaft being rotatably received within a central channel, further wherein a groove is formed in a lower end of the shaft for providing selective fluid communication between the selected one of the first and second ports;
a pump assembly for selectively transferring a metered dose of the liquid medicament to the dispensing assembly for dispensing through the groove and a selected one of the first and second ports, wherein an upper wall of the cap has a central opening formed therethrough, a stem of the pump assembly being slidably received therethrough;
a spray nozzle in fluid communication with the first port; and
a flexible spray tube in fluid communication with the second port;
wherein the spray nozzle is adapted for dispensing of the metered dose to at least a first nasal passage of a user of the nasal sprayer; and
wherein the flexible spray tube is adapted for dispensing of the metered dose to at least one of a Eustacian tube, an adenoid region, and a sinus region of a user of the nasal sprayer.

US Pat. No. 10,391,267

DOSE COUNTERS FOR INHALERS, INHALERS AND METHODS OF ASSEMBLY THEREOF

IVAX PHARMACEUTICALS IREL...

1. A method of manufacturing a series of incremental dose counters for metered dose inhalers, each metered dose inhaler comprising a medicament-containing canister, wherein each incremental dose counter in the series comprises:a ratchet wheel having a plurality of circumferentially spaced teeth and a central axis which is above a datum plane,
an actuator pawl comprising a lower side edge arranged to engage with and rotate the ratchet wheel,
a count pawl arranged to repeatedly engage the ratchet wheel in a series of anti-back drive interlock configurations, and
a dosage indicator coupled to the ratchet wheel,
which method comprises:
positioning the ratchet wheel, the actuator pawl and the count pawl relative to the datum plane in each dose counter in the series so that, in a canister fire process, the actuator pawl is arranged to define a first reset position in which the lower side edge of the actuator pawl is brought into engagement with a first tooth of the ratchet wheel above the datum plane; and a nominal canister fire position, after the first reset position, in which the lower side edge of the actuator pawl and ratchet wheel have moved to a second position at which the canister fires medicament and which is a first distance below the datum plane; and a nominal dose count position in which the lower side edge of the actuator pawl is a second distance below the datum plane that is greater than the first distance, and the count pawl has just resiliently jumped over a second tooth of the ratchet wheel from a first anti-back drive interlock configuration to a second anti-back drive interlock configuration and an incremental count is displayed by the dosage indicator,
wherein an average dose count position in the series is, in the canister fire process, at or after an average canister fire position in the series.

US Pat. No. 10,391,261

SYRINGE SECURING SYSTEM

1. A syringe retaining system comprising:a syringe retaining apparatus comprising: a syringe having a barrel with a main portion and a transition portion with a shoulder therebetween, and a needle extending from the transition portion of the barrel;
a protective cap removably mounted on the syringe, the protective cap being configured to receive the needle of the syringe and at least a portion of the transition portion of the barrel of the syringe, the protective cap having an open proximal end and a closed distal end, the protective cap having a tip portion at the distal end and a flange adjacent to the proximal end, the protective cap having an interior surface and an exterior surface;
a locking structure configured to permit removal of the protective cap from the syringe when the syringe is inserted to a first depth of insertion into the protective cap and to resist removal of the protective cap from the syringe when the syringe is inserted into the protective cap to a second depth of insertion, the second depth of insertion of the syringe into the protective cap being deeper into the protective cap than the first depth of insertion;
a spacer element removably mounted in a mounted condition on the transition portion of the syringe in a position between the shoulder of the syringe and the flange of the protective cap, the mounted condition of the spacer element being characterized by permitting the syringe to be inserted into the protective cap to the first depth of insertion and preventing the syringe to be inserted into the protective cap to the second depth of insertion, wherein removal of the spacer element from the mounted condition on the syringe permits insertion of the syringe into the protective cap to the second depth of insertion to resist removal of the protective cap from the syringe; and
wherein the spacer element is fully separable from the syringe and the protective cap to permit the spacer element to fall away from the syringe and the protective cap when the protective cap is removed from the syringe such that the spacer element is absent during any reinsertion of the syringe into the protective cap.

US Pat. No. 10,391,260

HYPODERMIC NEEDLE ASSEMBLY IDENTIFICATION AND RELATED METHODS

1. A needle assembly, comprising:a needle cannula with a distal end and a proximal end, the needle cannula has an outer surface defining a circumference and the needle cannula defines an axis that is linear between the distal end and the proximal end; and,
an identification tag comprising machine readable information that uniquely identifies said needle assembly, the identification tag affixed to a portion of the outer surface, an attachment between the identification tag and the outer surface comprising less than the circumference.

US Pat. No. 10,391,259

DOSE DIVIDER SYRINGE

TELEFLEX MEDICAL INCORPOR...

1. A syringe, comprising: a barrel having an internal surface defining an internal bore therein, the barrel further comprising a flange disposed near a proximal end of the barrel; a plunger disposed within the internal bore of the barrel, the plunger having a shaft having a longitudinal axis; a dose divider disposed on the plunger, the dose divider being rotatable about the longitudinal axis of the plunger, the dose divider including a first end, a first abutment surface facing an axial direction along the longitudinal axis of the plunger, the first abutment surface being spaced apart from the first end in the axial direction by a first axial distance, wherein the first abutment surface is configured to bear on the flange of the barrel when the plunger is in a first axial position relative to the barrel, and a second abutment surface facing the axial direction, the second abutment surface being spaced apart from the first end in the axial direction by a second axial distance, the second axial distance being greater than the first axial distance, the second abutment surface being spaced apart from the longitudinal axis of the plunger by a first radial distance, wherein the second abutment surface is configured to bear on the flange of the barrel when the plunger is in a second axial position relative to the barrel, the second axial position being different from the first axial position, wherein the dose divider further includes a third abutment surface facing the axial direction, the third abutment surface being spaced apart from the first end in the axial direction by a third axial distance, the third axial distance being greater than the second axial distance, the third abutment surface being spaced apart from the longitudinal axis of the plunger by a second radial distance, wherein the third abutment surface is configured to bear on the flange of the barrel when the plunger is in a third axial position relative to the barrel, the third axial position being different from the first axial position and the second axial position wherein the first radial distance and the second radial distance are greater than a radial distance from a longitudinal axis of the barrel to the internal surface of the barrel in which the plunger is disposed and which is distal to the flange.

US Pat. No. 10,391,258

SETTING MECHANISM

COPERNICUS SP. Z O.O., S...

1. An applicator comprising:a housing comprising an inspection opening,
a dose setting knob coupled to the housing,
a setting mechanism coupled by a connecting element to the dose setting knob,
at least two coil springs comprising a driving coil spring extending in an axial direction,
a non-rotatable lock connected to the housing and to the driving coil spring,
a rotatable driving sleeve connected to the driving coil spring,
an indicating sleeve connected movably with the rotatable driving sleeve,
wherein the indicating sleeve is mounted slidingly and co-axially on the rotatable driving sleeve by a spline coupling comprising longitudinal protrusions,
wherein the housing comprises a first end portion with a first external diameter and a second end portion with a second external diameter, the second external diameter being greater than the first external diameter,
wherein the dose setting knob is rotatable and comprises at least one protrusion to couple with the first end portion of the housing,
wherein the connecting element comprises a longitudinal sleeve and extends above the first end portion of the housing to couple with the dose setting knob,
wherein the first end portion of the housing comprises at least two openings arranged non-coaxially,
wherein the non-rotatable lock comprises a curved surface to cover at least a portion of the at least two openings of the first end portion of the housing,
wherein the non-rotatable lock comprises a through-bore to receive the longitudinal sleeve of the connecting element, an opening to attach the driving coil spring and a wall to separate at least partially the through-bore from the opening,
wherein the wall of the non-rotatable lock covers at least a portion of the longitudinal sleeve of the connecting element,
wherein the longitudinal sleeve of the connecting element comprises a first end portion comprising protrusions and a second end portion to receive at least a portion of a piston rod,
wherein the piston rod is coupled to the driving coil spring, the driving coil spring being configured to drive the piston rod,
wherein the dose setting knob covers at least a portion of the wall of the non-rotatable lock, the curved surface of the non-rotatable lock, the first end portion of the housing and the protrusions of the first end portion of the longitudinal sleeve of the connecting element,
wherein the dose setting knob, the housing, the non-rotatable lock, the driving sleeve, the indicating sleeve, the driving coil spring, the connecting element and the piston rod are arranged coaxially.

US Pat. No. 10,391,255

APPARATUS AND METHODS FOR TRACKING ADMINISTERING OF MEDICATION BY SYRINGE

Verily Life Sciences LLC,...

1. A system for tracking administering of a medication dispensed by a syringe, comprising:a plunger head that fits within a barrel of the syringe, the plunger head comprising:
a transducer that sends and receives ultrasonic signals;
a first antenna; and
a first microcontroller that interfaces with the transducer and the antenna;
a cuff that is attachable to the barrel of the syringe, the cuff comprising:
a second microcontroller;
a second antenna that receives information from the plunger head via the first antenna; and
a power source;
wherein the first microcontroller is programmed with instructions to measure a time for the ultrasonic signals to travel from the transducer in the plunger head through the medication in the syringe to an end of the barrel and return to the transducer, the second microcontroller is programmed with instructions to calculate data representative of a quantity of medication dispensed from the barrel based on a change in the time measured.

US Pat. No. 10,391,250

ATTACHABLE PLUNGER ROD AND ASSOCIATED PACKAGING

Becton Dickinson France, ...

1. A syringe assembly, comprising:a syringe barrel having a first end, a second end, and a sidewall extending therebetween and defining a chamber having an interior;
a stopper slidably disposed within the interior of the chamber of the syringe barrel and defining an aperture therein, the stopper comprising a deformable restraining member adjacent the aperture, the deformable restraining member transitionable between a deformed position to an undeformed position;
a plunger rod having a first end, a second end, and a plunger rod head disposed adjacent the first end of the plunger rod; and
an oxygen absorber contained within the plunger rod,
wherein as the plunger rod head is moved axially within the aperture of the stopper, the plunger rod head deforms the restraining member of the stopper, and once the plunger rod head is advanced beyond the restraining member of the stopper, the restraining member returns to its undeformed position to secure the plunger rod head within the aperture.

US Pat. No. 10,391,249

DROPPER SYRINGE APPARATUS

1. A dropper syringe apparatus for drawing or dispensing fluid from or to an external body, the dropper syringe apparatus comprising:a substantially cylindrical barrel comprising a first opening and a second opening, the second opening smaller than the first opening, wherein the first opening is flanged as two symmetrical finger grips, and wherein the substantially cylindrical barrel is configured to store the fluid;
a plunger assembly configured to be inserted into the substantially cylindrical barrel, the plunger assembly comprising:
a plunger shaft comprising a flanged upper end, a lower end, and a central lumen, the plunger shaft configured to move in an upward direction and a downward direction within the substantially cylindrical barrel, wherein the central lumen extends from the lower end to the flanged upper end of the plunger shaft for accommodating the fluid;
a flexible hollow bulb fixedly attached to the flanged upper end of the plunger shaft, wherein an interior of the flexible hollow bulb is in fluid communication with the central lumen, the flexible hollow bulb configured to exert a pressure on the fluid accommodated within the central lumen based on an external force exerted on the flexible hollow bulb;
a needle detachably attached to a first hollow neck element extending from the second opening of the substantially cylindrical barrel, the needle configured to draw or dispense the fluid from or to the external body; andfurther comprising a second hollow neck element attached to the flanged upper end of the plunger shaft, the second hollow neck element housed within the flexible hollow bulb, wherein the second hollow neck element is in fluid communication with the central lumen of the plunger shaft and the flexible hollow bulb to transfer fluid between the central lumen and the flexible hollow bulb.

US Pat. No. 10,391,248

ADAPTOR AND DRUG DELIVERY DEVICE

Becton Dickinson France, ...

1. An adaptor for use with a drug delivery device having a reservoir for containing a product, said adaptor comprising:a collar engageable with a distally projecting end-piece of said reservoir, said collar having an elongated shape and comprising a proximal region and a distal region, said collar comprising an abutment surface on an inner wall of the collar, said abutment surface configured to directly contact a radial proximal face of an annular ridge on an outer wall of the distally projecting end-piece of said reservoir when said collar is urged in a distal direction to engage with said distally projecting end-piece, wherein said abutment surface is configured to limit translational movement of said collar with respect to said distally projecting end-piece once said collar is engaged with the distally projecting end-piece;
at least one adaptor anti-rotation member configured to limit the rotation of said collar with respect to said distally projecting end-piece once said collar is engaged with the distally projecting end-piece; and
at least one deactivating member configured to neutralize said at least one adaptor anti-rotation member in response to a turning torque equal to or greater than a predetermined value applied to said collar when said collar is engaged with said distally projecting end-piece, thereby allowing the rotation of said collar with respect to said distally projecting end-piece.

US Pat. No. 10,391,246

AUTOINJECTOR

Sanofi-Aventis Deutschlan...

1. An autoinjector comprising:a syringe comprising a body and a needle carried by the body, the syringe being movable to advance the needle for insertion along a needle insertion direction;
a case configured to receive the syringe;
a door hingedly coupled to the case and having an open position and a closed position;
a plunger slidably disposed in the case; and
two parallel compression drive springs disposed on opposite sides of the syringe and positioned between a proximal end of the case and a distal end of the plunger, the two parallel compression drive springs respectively defining two axes along which the two parallel compression drive springs are compressible and that are parallel to the needle insertion direction, the two parallel compression drive springs configured to apply a biasing force on the plunger relative to the case, and the plunger being configured to advance the syringe relative to the case and to advance a stopper of the syringe relative to the body of the syringe when the two parallel compression drive springs apply the biasing force on the plunger,
wherein the door is operably coupled to the plunger in a manner such that rotation of the door from the closed position to the open position moves the plunger from a distal position in the case to a proximal position in the case and compresses the two parallel compression drive springs.

US Pat. No. 10,391,245

MEDICAMENT DEVICE

Becton, Dickinson and Com...

1. An apparatus for making a sterile connection, comprising:a container;
a sealing member sealing a first end of the container;
a barrier sealing a chamber in fluid communication with the sealing member; and
a valve sleeve assembly, comprising:
a flexible sleeve having a barrier portion at an end of the flexible sleeve, an interior of the flexible sleeve being sterile;
a hollow first penetrator adapted to displace relative to the flexible sleeve; and
a hollow second penetrator at least partially disposed within the first penetrator and adapted to displace relative to the first penetrator and the flexible sleeve;
wherein in an initial state, the flexible sleeve encloses the first penetrator and a penetrating end of the second penetrator;
wherein one of the container and the valve sleeve assembly is adapted to displace relative to the remaining one of the container and the valve sleeve assembly;
wherein the flexible sleeve is adapted to collapse, thereby displacing the outer first penetrator relative to the flexible sleeve to pierce the barrier portion and the barrier; and
wherein upon further relative displacement between the container and the valve sleeve assembly, subsequent to the piercing of the barrier portion and the barrier, the second penetrator is adapted to displace relative to the first penetrator to pierce the sealing member to create a sterile connection with the interior of the container.

US Pat. No. 10,391,241

SYRINGE PUMP HAVING A PRESSURE SENSOR ASSEMBLY

DEKA Products Limited Par...

1. A pressure sensor assembly, comprising:a plunger comprising:
a sensing surface, the sensing surface having an elongated portion along a first axis and a width along a second axis, the first and second axes are orthogonal relative to each other, wherein the width is about constant along a substantial portion of elongated portion, wherein the elongated portion of the sensing surface defines first and second ends, wherein the first and second ends are curved;
a first extension disposed adjacent to or on the first end of the sensing surface and extending along a third axis orthogonal to the first and second axes away from sensing surface; and
a second extension disposed adjacent to or on the second end of the sensing surface and extending along a fourth axis orthogonal to the first and second axes away from sensing surface, wherein the third and fourth axes are parallel to each other;
a guide configured to guide the movement of the plunger along the third and fourth axes;
a first pressure sensor disposed adjacent to an end of the first extension opposite to the sensing surface, the first pressure sensor is configured to sense movement of the plunger within the guide; and
a second pressure sensor disposed adjacent to an end of the second extension opposite to the sensing surface, the second pressure sensor is configured to sense movement of the plunger within the guide.

US Pat. No. 10,391,239

RESERVOIR PRESSURE EQUALIZATION SYSTEMS AND METHODS

Medtronic MiniMed, Inc., ...

1. A base assembly for a fluid delivery system comprising a fluid reservoir with a fluid vent for expelling pressurized fluidic media from the fluid reservoir, the base assembly comprising:a proximal portion;
a distal portion formed with a fluid delivery port to accommodate transfer of fluidic media;
a valve to cooperate with the fluid delivery port;
a recess to accommodate the fluid reservoir in a first state of the base assembly, and to accommodate the valve in a second state of the base assembly; and
a sealing arrangement that cooperates with the valve and the fluid reservoir;
wherein, in the first state, the sealing arrangement cooperates with the fluid reservoir to form a fluid tight chamber in fluid communication with the fluid vent of the fluid reservoir; and
wherein, in the second state, the sealing arrangement cooperates with the valve to inhibit access to the fluid delivery port.

US Pat. No. 10,391,238

INTELLIGENT INFUSION SYSTEM AND INFUSION METHOD USING INTELLIGENT INFUSION SYSTEM

BOE TECHNOLOGY GROUP CO.,...

1. An intelligent infusion system, comprising:a positioning device configured to determine a coordinate origin;
an imaging device configured to capture a first image of an object to be detected in a first state and a second image of the object to be detected in a second state;
a processing device configured to compare the first image and the second image to determine one or more objects to be processed and image data of each object to be processed;
a calculation device configured to select a target object from the one or more objects to be processed, select a first position on the target object according to image data of the target object and determine coordinates of the first position based on the coordinate origin; and
a control device configured to control a robotic arm to reach a liquid input region and control the robotic arm to move a infusion needle to the coordinates of the first position for liquid infusion.

US Pat. No. 10,391,236

INTEGRATED INTRAVENOUS (IV) CLAMP AND POWER SUPPLY

INTERNATIONAL BUSINESS MA...

1. A method of operating an intravenous (IV) device transportation apparatus power system, the method comprising:clamping a hinged clamp, on which IV devices are supported, to a non-conductive support element;
embedding power distribution elements in a floor;
receiving power for operating the IV devices in the non-conductive support element; and
distributing and selectively transmitting the received power to the IV devices along the non-conductive support element.

US Pat. No. 10,391,231

METHOD AND DEVICE FOR SEPARATING BLOOD USING A CENTRIFUGE

1. A method for separating blood using a centrifuge in order to obtain different blood fractions, said method comprising:filling a separation container with blood via a feed port using a feed device that is aseptically connected to the separation container;
centrifuging the separation container; and
extracting the relevant blood fraction from the separation container via an extraction port using an extraction device that is aseptically connected to the separation container,
wherein during the aseptic connection to the separation container, the feed device and the extraction device form in each case a closed system,
wherein the feed device and the extraction device each comprise a syringe disposed inside a sleeve,
wherein an inner line is disposed in an interior of the extraction device,
wherein the inner line is configured to be handled via a bellows of the extraction device, and
wherein the bellows is aseptically connected to the sleeve of the syringe of the extraction device.

US Pat. No. 10,391,230

CANNULA DEVICE, ARTIFICIAL LUNG

CENTRE CHIRURGICAL MARIE ...

1. A cannula device for the circulation of a blood in an artificial lung, the cannula device comprising:an aspiration lumen comprising at least one orifice configured to aspirate a volume of blood low in oxygen,
an injection lumen comprising at least one orifice configured to inject a volume of oxygenated blood,
wherein the injection lumen and the aspiration lumen are held rigidly connected over at least a portion of their length, said injection and aspiration lumens being sealed in relation to each other, wherein the injection lumen being the only lumen of the cannula device which comprises at a distal end thereof a deformable element which is meshed so as to enable a passage of blood between its meshes, said deformable element being held over a portion of the distal end thereof, said deformable element comprising a first setting and a second setting, a change from the first setting to the second setting being effected by a modification of a diameter of said deformable element.

US Pat. No. 10,391,224

PRESSURE SENSING EXTRACORPOREAL CIRCULATION DEVICE

TERUMO KABUSHIKI KAISHA, ...

1. An extracorporeal circulation system comprising:a blood removal line to withdraw blood from inside a body of a subject;
a centrifugal pump connected downstream of the blood removal line and operating at a set speed;
speed measuring equipment associated with the centrifugal pump to detect a rotation speed of the centrifugal pump;
an oxygenator connected downstream relative to the centrifugal pump via an intermediate tube;
a blood sending line downstream relative to the oxygenator to return blood to the body;
a flow rate sensor to detect a blood flow rate in the blood sending line;
an intermediate part pressure sensor to detect pressure in the intermediate tube between the centrifugal pump and the oxygenator;
a discharge pressure identifying unit programmed with a predetermined correlation between a pump discharge pressure, a pump flow rate, and a pump rotation speed, wherein the predetermined correlation is specific to a particular preexisting design of the centrifugal pump, and wherein the discharge pressure identifying unit is programmed to identify a corresponding discharge pressure according to the detected rotation speed of the centrifugal pump and the blood flow rate detected in the flow rate sensor; and
a blood removal pressure calculating unit programmed to subtract the discharge pressure identified in the discharge pressure identifying unit from the pressure measured by the intermediate part pressure sensor to estimate pressure in the blood removal line.

US Pat. No. 10,391,222

DEVICES FOR UREA ELECTROLYSIS AND METHODS OF USING SAME

BAXTER INTERNATIONAL INC....

1. A device for the removal of urea from a fluid having urea to produce a cleansed fluid, the device comprising:a urea decomposition unit comprising an inlet for entry of the fluid having urea and an outlet for removal of the cleansed fluid, and one or more sets of electrodes each having an anode and a cathode, wherein the anode of the one or more sets of electrodes is provided with an electrocatalytic surface for decomposition of urea via electrooxidation; and
an electrodialysis unit comprising
a bipolar membrane;
at least two ion exchange membranes; and
a set of electrodes having an anode and a cathode for separation of the fluid having urea via electrodialysis, where the fluid having urea is separated into an acid stream and a basic stream,
wherein the basic stream of the electrodialysis unit is placed in fluid communication with the inlet of the urea decomposition unit, wherein the basic stream of the electrodialysis unit is oxidized by the one or more set of electrodes, and wherein the acid stream separated from the fluid having urea is placed in fluid communication with the basic stream oxidized by the one or more set of electrodes of the urea decomposition unit to produce a neutralized, cleansed fluid.

US Pat. No. 10,391,221

METHODS OF MAKING MEDICAL SOLUTIONS AND RELATED SYSTEMS

Fresenius Medical Care Ho...

1. A dialysis system comprising:a container containing a dissolvable solid concentrate;
an input line connected to the container and to a valve that controls the flow of a liquid into the container;
an output line connected to the container and to a pump;
an air separation chamber fluidly connected to the container;
a first conductivity sensor connected to the input line and configured to obtain a first measure of conductivity of the liquid supplied to the container;
a second conductivity sensor connected to the air separation chamber and configured to obtain a second measure of conductivity of a solution leaving the air separation chamber; and
a data processing apparatus connected to the valve and configured for:
introducing a quantity of the liquid into the container through the input line based on the first measure of conductivity of the liquid supplied to the container and the second measure of conductivity of the solution leaving the air separation chamber, the liquid introduced in a manner so that a layer of solution above the solid concentrate is maintained at a depth that allows the liquid introduced into the container to agitate the solution adjacent to the solid concentrate to cause mixing of the solid concentrate with the solution.

US Pat. No. 10,391,217

AXIAL FLOW IMPLANTABLE MECHANICAL CIRCULATORY SUPPORT DEVICES WITH OUTLET VOLUTE

HeartWare, Inc., Miami L...

1. A mechanical circulatory support device, comprising:an inner housing having an inlet end, an outlet end, and a flow path there between, the flow path defining a longitudinal axis;
a volute downstream of the outlet end having an outlet port;
a rotor mounted within the inner housing upstream of the volute and configured to rotate about the longitudinal axis, the rotor having a proximal end and a distal end; and
the volute including an inner surface having a minimum radius immediately adjacent the distal end of the rotor and progressively increasing to a maximum radius at the outlet port.

US Pat. No. 10,391,214

BREAST SHIELD UNIT

MEDELA HOLDING AG, Baar ...

1. A breastshield unit for use with a breastpump for expressing human breastmilk by means of underpressure, comprising a dimensionally stable breastshield and a flexible breastshield insert for placing in the breastshield, the breastshield having a first, open breastshield end for placing on a mother's breast, the breastshield insert havinga first insert end,
a second insert end,
a bearing area for placing on a mother's breast, the bearing area adjoining the first insert end and comprising a receiving opening leading from the first insert end to the second insert end,
and a tubular stub formed integrally on the bearing area and extending as far as the second insert end, the first and second insert ends together defining a longitudinal direction,
the first, open breastshield end having a peripheral edge, on which the breastshield insert is securable with the first insert end,
the breastshield insert, in an assembled state, extending from the first insert end through an inside of the breastshield to the second insert end,
the breastshield insert, between the first and second insert ends, extending substantially spaced apart from the breastshield,
and, in the assembled state of the breastshield insert, the second insert end is displaceable in the longitudinal direction relative to the breastshield, to adapt the breastshield insert to a shape of the breast and to provide a bearing force,
wherein the bearing area extends approximately perpendicularly with respect to the longitudinal direction before being applied to the mother's breast and wherein the bearing area is approximately flat before being applied to the mother's breast, wherein the bearing area adapts to the shape of the mother's breast when applied to the mother's breast.

US Pat. No. 10,391,213

SYSTEMS AND METHODS FOR THERAPEUTIC PLATELET DEPLETION

Fenwal, Inc., Lake Zuric...

1. A method of depleting platelets from blood from a blood source, comprising:(a) executing a cycle comprising
conveying blood into a first stage of a blood separation chamber,
separating the blood in the first stage of the blood separation chamber into platelet-rich plasma and red blood cells,
conveying at least a portion of the platelet-rich plasma into a second stage of the blood separation chamber,
separating said at least a portion of the platelet-rich plasma in the second stage of the blood separation chamber into platelets and platelet-poor plasma, and
conveying at least a portion of the platelet-poor plasma out of the second stage of the blood separation chamber while allowing the platelets to accumulate in the second stage of the blood separation chamber;
(b) determining that a maximum chamber capacity of platelets has accumulated in the second stage of the blood separation chamber; and
(c) ending the cycle by conveying the accumulated platelets out of the second stage of the blood separation chamber, wherein
said determining that the maximum chamber capacity of platelets has accumulated in the second stage of the blood separation chamber comprises determining that a predetermined cycle amount of blood has been conveyed into the first stage of the blood separation chamber, and
the predetermined cycle amount of blood to be conveyed into the first stage of the blood separation chamber is calculated using the equation:

 wherein
WBper cycle (+AC) is an amount of anticoagulated whole blood to be conveyed into the first stage of the blood separation chamber during the cycle,
TBV is a total blood volume of the blood source,
CE is a platelet collection efficiency of a blood separation device used in combination with the blood separation chamber to deplete platelets from the blood,
Max Capacity of Plts is the maximum chamber capacity of platelets to be accumulated in the second stage of the blood separation chamber,
Pltcycle is a platelet concentration of the blood at the beginning of the cycle, and

 is a ratio of anticoagulant to blood of the anticoagulated whole blood to be conveyed into the first stage of the blood separation chamber.

US Pat. No. 10,391,212

DEVICE AND METHOD FOR WOUND THERAPY

1. A wound dressing comprising:a wound interface layer;
a flexible wound cover configured to cover at least a portion of a wound;
a first region comprising an absorbent layer positioned between the flexible wound cover and the wound interface layer;
a second region comprising a source of negative pressure positioned over the wound interface layer and configured to deliver a reduced pressure to the wound; and
a liquid barrier configured to prevent liquid from reaching the source of negative pressure;
wherein the first region and the second region are positioned over the wound interface layer with the second region offset from the first region; and
wherein the flexible wound cover covers at least the first region.

US Pat. No. 10,391,209

SYSTEM AND METHOD FOR GUIDED REMOVAL FROM AN IN VIVO SUBJECT

The General Hospital Corp...

1. A method for removing an object, comprising:guiding a flexible tube having an external diameter of at least about 11 French through a passageway of an in vivo subject using an introducer configured to provide support to the flexible tubing during insertion of the flexible tube, wherein the flexible tube comprises at least a first passageway and a second passageway encompassed by the first passageway and the introducer is configured to pass through the first passageway and accommodate the second passageway in a groove during insertion of the flexible tube through the passageway of the in vivo subject;
positioning a distal end of the first passageway adjacent to the object;
infusing liquid through the second passageway, wherein the liquid comprises saline solution; and
causing suction to be applied by a suction source coupled, via a valve, to a proximal end of the first passageway to remove the object and at least a portion of the liquid through the first passageway after infusion of the liquid through the second passageway.

US Pat. No. 10,391,199

POROUS MATERIALS, METHODS OF MAKING AND USES

ALLERGAN, INC., Irvine, ...

1. A method for forming a textured implant shell, the method comprising:coating a base shell with a first layer of an elastomer, the elastomer comprising a silicone base and a solvent;
applying porogens to the first layer of elastomer to form a first porogen-coated elastomer layer;
applying a second layer of the elastomer to the first porogen-coated elastomer layer;
applying porogens to the second layer of elastomer to form a second porogen-coated elastomer layer;
applying a third layer of the elastomer to the second porogen-coated elastomer layer to thereby form a multilayered porogen/elastomer coating on the base shell;
treating the multilayered porogen/elastomer coating on the base shell such that during the treatment the porogens become fused to one another while the uncured elastomer layers become cured, thereby forming a fused porogen scaffold surrounded by cured elastomer; and
removing the porogen scaffold from the cured elastomer, wherein the removing the porogen scaffold results in an interconnected open-cell textured implant shell;
wherein the porogens comprise poly(ethylene) glycol.

US Pat. No. 10,391,175

BET BROMODOMAIN INHIBITORS AND THERAPEUTIC METHODS USING THE SAME

THE REGENTS OF THE UNIVER...

17. A method of reducing or ameliorating a proliferative disorder, the method comprising administering a therapeutically effective amount of a compound having formula (I):
wherein:
X is N(Ra);
Y1 and Y3, independently, are CH or N;
Y2 is CH, CRa, or N;
Z is H,
halo, or OH;A is
each unsubstituted or substituted;B is aryl, CH(Ra)-aryl, C3-10cycloalkyl, CH(Ra)—C3-10cycloalkyl, heteroaryl, CH(Ra)-heteroaryl, C3-10heterocycloalkyl, or CH(Ra)—C3-10heterocycloalkyl, each unsubstituted or substituted;
G is N, O, or S;
L is null, H, or C(Rd)3;
R1 is H, halo, OH, ORE, or N(Ra)2;
Ra, independently, is H, C1-3alkyl, or benzyl;
Rb, independently, is C1-6alkyl, halo, aryl, unsubstituted or substituted CH2-aryl, unsubstituted or substituted C3-10cycloalkyl, unsubstituted or substituted CH2—C3-10cycloalkyl, heteroaryl, unsubstituted or substituted CH2-heteroaryl, unsubstituted or substituted C3-10heterocycloalkyl, or unsubstituted or substituted CH2—C3-10heterocycloalkyl, or CHO;
n is an integer 0, 1, 2, or 3; and
Rc and Rd, each independently, are hydrogen, C1-6alkyl, unsubstituted or substituted aryl, unsubstituted or substituted CH2-aryl, unsubstituted or substituted C3-10cycloalkyl, unsubstituted or substituted CH2—C3-10cycloalkyl, heteroaryl, unsubstituted or substituted CH2-heteroaryl, unsubstituted or substituted C3-10heterocycloalkyl, or unsubstituted or substituted CH2—C3-10heterocycloalkyl;
or a pharmaceutically acceptable salt, hydrate, or solvate thereof,
to an individual in need thereof.

US Pat. No. 10,391,172

USE OF NANODIAMONDS FOR GENERATING FREE RADICALS FOR THERAPEUTIC PURPOSES UNDER RADIATION

1. A method of generating free radicals for therapeutic purposes comprising a step of exposing nanodiamonds to radiation,wherein the nanodiamonds are beforehand subjected to a graphitization, or a graphitization and a hydrogenation to have a surface that has been at least partially graphitized, or graphitized and hydrogenated, respectively.

US Pat. No. 10,391,106

19-NOR C3, 3-DISUBSTITUTED C21-C-BOUND HETEROARYL STEROIDS AND METHODS OF USE THEREOF

Sage Therapeutics, Inc., ...

1. A compound of the formula:

US Pat. No. 10,391,098

ANTISENSE ANTIBACTERIAL COMPOUNDS AND METHODS

Board of Regents, The Uni...

1. An antisense morpholino oligomer of formula (I):
or a pharmaceutically acceptable salt thereof,
where each Nu is a nucleobase which taken together forms a targeting sequence,
where the targeting sequence is set forth in SEQ ID NOS: 2-11, comprises a fragment of at least 10 contiguous nucleotides of SEQ ID NOS: 2-11, or comprises a variant having at least 80% sequence identity to SEQ ID NOS: 2-11, where thymine bases (T) are optionally uracil bases (U);
X is an integer from 9 to 38;
T is selected from OH and a moiety of the formula:

where each R4 is independently C1-C6 alkyl, and R5 is selected from an electron pair and H, and R6 is selected from OH, —N(R7)CH2C(O)NH2, and a moiety of the formula:

where
R7 is selected from H and C1-C6 alkyl; and
R8 is selected from G, —C(O)R9OH, acyl, trityl, and 4-methoxytrityl, where:
R9 is of the formula —(O-alkyl)Y- where y is an integer from 3 to 10 and each of the y alkyl groups is independently selected from C2-C6 alkyl;
each of R1 is =N(R10)2R11 where each R10 is independently C1-C6 alkyl, and R11 is selected from an electron pair and H;
R2 is selected from H, G, acyl, trityl, 4-methoxytrityl, benzoyl, stearoyl, and a moiety of the formula:

where L is selected from —C(O)(CH2)6C(O)— and —C(O)(CH2)2S2(CH2)2C(O)—, and each R12 is of the formula (CH2)2OC(O)N(R14)2where each R14 is of the formula —(CH2)6NHC(?NH)NH2; and
R3 is selected from an electron pair, H, and C1-C6 alkyl,
where G is a cell penetrating peptide (“CPP”) and linker moiety selected from —C(O)(CH2)hd 5NH-CPP, —C(O)(CH2)2NH-CPP, —C(O)(CH2)2NHC(O)(CH2)5NH-CPP, and —C(O)CH2NH-CPP, or G is of the formula:

where the CPP is attached to the linker moiety by an amide bond at the CPP carboxy terminus, and
wherein the CPP is selected from:

where Ra is selected from H, acetyl, benzoyl, and stearoyl, with the proviso that R2 or R8 is G,
where the targeting sequence specifically hybridizes to a bacterial mRNA target sequence that encodes a protein selected from at least one of a protein associated with a biochemical pathway and/or cellular process and antibiotic resistance.

US Pat. No. 10,391,089

PRMT5 INHIBITORS AND USES THEROF

Epizyme, Inc., Cambridge...

1. A method of inhibiting PRMT5, altering gene expression, or altering transcription, comprising contacting a cell with an effective amount of a compound of formula (I), or a pharmaceutically acceptable salt thereof:wherein represents a single or double bond;
R1 is hydrogen, Rz, or C(O)Rz, wherein Rz is optionally substituted C1-6 alkyl;
L is —N(R)C(O)—, —C(O)N(R)—, —N(R)C(O)N(R)—, —N(R)C(O)O—, or —OC(O)N(R)—;
each R is independently hydrogen or optionally substituted C1-6 aliphatic;
Ar is a monocyclic or bicyclic aromatic ring having 0-4 heteroatoms independently selected from nitrogen, oxygen, and sulfur, wherein Ar is substituted with 0, 1, 2, 3, 4, or 5 Ry groups, as valency permits;
each Ry is independently selected from the group consisting of halo, —CN, —NO2, optionally substituted aliphatic, optionally substituted carbocyclyl, optionally substituted aryl, optionally substituted heterocyclyl, optionally substituted heteroaryl, —ORA, —N(RB)2, —SRA, —C(?O)RA, —C(O)ORA, —C(O)SRA, —C(O)N(RB)2, —C(O)N(RB)N(RB)2, —OC(O)RA, —OC(O)N(RB)2, —NRBC(O)RA, —NRBC(O)N(RB)2, —NRBC(O)N(RB)N(RB)2, —NRBC(O)ORA, —SC(O)RA, —C(?NRB)RA, —C(?NNRB)RA, —C(?NORA)RA, —C(?NRB)N(RB)2, —NRBC(?NRB)RB, —C(?S)RA, —C(?S)N(RB)2, —NRBC(?S)RA, —S(O)RA, —OS(O)2RA, —SO2RA, —NRBSO2RA, or —SO2N(RB)2;
each RA is independently selected from the group consisting of hydrogen, optionally substituted aliphatic, optionally substituted carbocyclyl, optionally substituted heterocyclyl, optionally substituted aryl, and optionally substituted heteroaryl;
each RB is independently selected from the group consisting of hydrogen, optionally substituted aliphatic, optionally substituted carbocyclyl, optionally substituted heterocyclyl, optionally substituted aryl, and optionally substituted heteroaryl, or two RB groups are taken together with their intervening atoms to form an optionally substituted heterocyclic ring;
R5, R6, R7, and R8 are independently hydrogen, halo, or optionally substituted aliphatic;
each Rx is independently selected from the group consisting of halo, —CN, optionally substituted aliphatic, —OR?, and —N(R?)2;
R? is hydrogen or optionally substituted aliphatic;
each R? is independently hydrogen or optionally substituted aliphatic, or two R? are taken together with their intervening atoms to form a heterocyclic ring; and
n is 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, or 10, as valency permits;
wherein each instance of aliphatic is independently an alkyl, alkenyl, alkynyl, cycloalkyl, or cycloalkenyl group;
each instance of optionally substituted is independently unsubstituted or substituted, and each instance of substituted is, when on a carbon atom, halogen, —CN, —NO2, —N3, —SO2H, —SO3H, —OH, —ORaa, —ON(Rbb)2, —N(Rbb)2, —N(Rbb)3+X?, —N(ORcc)Rbb, —SH, —SRaa, —SSRcc, —C(?O)Raa, —CO2H, —CHO, —C(ORcc)2, —CO2Raa, —OC(?O)Raa, —OCO2Raa, —C(?O)N(Rbb)2, —OC(?O)N(Rbb)2, —NRbbC(?O)Raa, —NRbbCO2Raa, —NRbbC(?O)N(Rbb)2, —C(?NRbb)Raa, —C(?NRbb)ORaa, —OC(?NRbb)Raa, —OC(?NRbb)ORaa, —C(?NRbb)N(Rbb)2, —OC(?NRbb)N(Rbb)2, —NRbbC(?NRbb)N(Rbb)2, —C(?O)NRbbSO2Raa, —NRbbSO2Raa, —SO2N(Rbb)2, —SO2Raa, —SO2ORaa, —OSO2Raa, —S(?O)Raa, —OS(?O)Raa, —Si(Raa)3, —OSi(Raa)3 —C(?S)N(Rbb)2, —C(?O)SRaa, —C(?S)SRaa, —SC(?S)SRaa, —SC(?O)SRaa, —OC(?O)SRaa, —SC(?O)ORaa, —SC(?O)Raa, —P(?O)2Raa, —OP(?O)2Raa, —P(?O)(Raa)2, —OP(?O)(Raa)2, —OP(?O)(ORcc)2, —P(?O)2N(Rbb)2, —OP(?O)2N(Rbb)2, —P(?O)(NRbb)2, —OP(?O)(NRbb)2, —NRbbP(?O)(ORcc)2, —NRbbP(?O)(NRbb)2, —P(Rcc)2, —P(Rcc)3, —OP(Rcc)2, —OP(Rcc)3, —B(Raa)2, —B(ORcc)2, —BRaa(ORcc), C1-10 alkyl, C1-10 perhaloalkyl, C2-10 alkenyl, C2-10 alkynyl, C3-10 carbocyclyl, 3-14 membered heterocyclyl, C6-14 aryl, and 5-14 membered heteroaryl, wherein each alkyl, alkenyl, alkynyl, carbocyclyl, heterocyclyl, aryl, and heteroaryl is independently substituted with 0, 1, 2, 3, 4, or 5 Rdd groups;
or two geminal hydrogens on a carbon atom are replaced with the group ?O, ?S, ?NN(Rbb)2, ?NNRbbC(?O)Raa, ?NNRbbC(?O)ORaa, ?NNRbbS(?O)2Raa, ?NRbb, or ?NORcc;
each instance of substituted is, when on a nitrogen, independently hydrogen, —OH, —ORaa, —N(Rcc)2, —CN, —C(?O)Raa, —C(?O)N(Rcc)2, —CO2Raa, —SO2Raa, —C(?NRbb)Raa, —C(?NRcc)ORaa, —C(?NRcc)N(Rcc)2, —SO2N(Rcc)2, —SO2Rcc, —SO2ORcc, —SORaa, —C(?S)N(Rcc)2, —C(?O)SRcc, —C(?S)SRcc, —P(?O)2Raa, —P(?O)(Raa)2, —P(?O)2N(Rcc)2, —P(?O)(NRcc)2, C1-10 alkyl, C1-10 perhaloalkyl, C2-10 alkenyl, C2-10 alkynyl, C3-10 carbocyclyl, 3-14 membered heterocyclyl, C6-14 aryl, and 5-14 membered heteroaryl, or two Rcc groups attached to a nitrogen atom are joined to form a 3-14 membered heterocyclyl or 5-14 membered heteroaryl ring, wherein each alkyl, alkenyl, alkynyl, carbocyclyl, heterocyclyl, aryl, and heteroaryl is independently substituted with 0, 1, 2, 3, 4, or 5 Rdd groups;
each instance of Raa is, independently, selected from C1-10 alkyl, C1-10 perhaloalkyl, C2-10 alkenyl, C2-10 alkynyl, C3-10 carbocyclyl, 3-14 membered heterocyclyl, C6-14 aryl, and 5-14 membered heteroaryl, or two Raa groups are joined to form a 3-14 membered heterocyclyl or 5-14 membered heteroaryl ring, wherein each alkyl, alkenyl, alkynyl, carbocyclyl, heterocyclyl, aryl, and heteroaryl is independently substituted with 0, 1, 2, 3, 4, or 5 Rdd groups;
each instance of Rbb is, independently, selected from hydrogen, —OH, —ORaa, —N(Rcc)2, —CN, —C(?O)Raa, —C(?O)N(Rcc)2, —CO2Raa, —SO2Raa, —C(?NRcc)ORaa, —C(?NRcc)N(Rcc)2, —SO2N(Rcc)2, —SO2Rcc, —SO2ORcc, —SORaa, —C(?S)N(Rcc)2, —C(?O)SRcc, —C(?S)SRcc, —P(?O)2Raa, —P(?O)(Raa)2, —P(?O)2N(Rcc)2, —P(?O)(NRcc)2, C1-10 alkyl, C1-10 perhaloalkyl, C2-10 alkenyl, C2-10 alkynyl, C3-10 carbocyclyl, 3-14 membered heterocyclyl, C6-14 aryl, and 5-14 membered heteroaryl, or two Rbb groups are joined to form a 3-14 membered heterocyclyl or 5-14 membered heteroaryl ring, wherein each alkyl, alkenyl, alkynyl, carbocyclyl, heterocyclyl, aryl, and heteroaryl is independently substituted with 0, 1, 2, 3, 4, or 5 Rdd groups;
each instance of Rcc is, independently, selected from hydrogen, C1-10 alkyl, C1-10 perhaloalkyl, C2-10 alkenyl, C2-10 alkynyl, C3-10 carbocyclyl, 3-14 membered heterocyclyl, C6-14 aryl, and 5-14 membered heteroaryl, or two Rcc groups are joined to form a 3-14 membered heterocyclyl or 5-14 membered heteroaryl ring, wherein each alkyl, alkenyl, alkynyl, carbocyclyl, heterocyclyl, aryl, and heteroaryl is independently substituted with 0, 1, 2, 3, 4, or 5 Rdd groups;
each instance of Rdd is, independently, selected from halogen, —CN, —NO2, —N3, —SO2H, —SO3H, —OH, —ORee, —ON(Rff)2, —N(Rff)2, —N(Rff)3+X?, —N(ORcc)Rff, —SH, —SRee, —SSRee, —C(?O)Ree, —CO2H, —CO2Ree, —OC(?O)Ree, —OCO2Ree, —C(?O)N(Rff)2, —OC(?O)N(Rff)2, —NRffC(?O)Ree, —NRffCO2Ree, —NRffC(?O)N(Rff)2, —C(?NRff)ORee, —OC(?NRff)Ree, —OC(?NRff)ORee, —C(?NRff)N(Rff)2, —OC(?NRff)N(Rff)2, —NRffC(?NRff)N(Rff)2, —NRffSO2Ree, —SO2N(Rff)2, —SO2Ree, —SO2ORee, —OSO2Ree, —S(?O)Ree, —Si(Ree)3, —OSi(Ree)3, —C(?S)N(Rff)2, —C(?O)SRee, —C(?S)SRee, —SC(?S)SRee, —P(?O)2Ree, —P(?O)(Ree)2, —OP(?O)(Ree)2, —OP(?O)(ORee)2, C1-6 alkyl, C1-6 perhaloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocyclyl, 3-10 membered heterocyclyl, C6-10 aryl, 5-10 membered heteroaryl, wherein each alkyl, alkenyl, alkynyl, carbocyclyl, heterocyclyl, aryl, and heteroaryl is independently substituted with 0, 1, 2, 3, 4, or 5 Rgg groups, or two geminal Rdd substituents can be joined to form ?O or ?S;
each instance of Ree is, independently, selected from C1-6 alkyl, C1-6 perhaloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocyclyl, C6-10 aryl, 3-10 membered heterocyclyl, and 3-10 membered heteroaryl, wherein each alkyl, alkenyl, alkynyl, carbocyclyl, heterocyclyl, aryl, and heteroaryl is independently substituted with 0, 1, 2, 3, 4, or 5 Rgg groups;
each instance of Rff is, independently, selected from hydrogen, C1-6 alkyl, C1-6 perhaloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocyclyl, 3-10 membered heterocyclyl, C6-10 aryl and 5-10 membered heteroaryl, or two Rff groups are joined to form a 3-14 membered heterocyclyl or 5-14 membered heteroaryl ring, wherein each alkyl, alkenyl, alkynyl, carbocyclyl, heterocyclyl, aryl, and heteroaryl is independently substituted with 0, 1, 2, 3, 4, or 5 Rgg groups; and
each instance of Rgg is, independently, halogen, —CN, —NO2, —N3, —SO2H, —SO3H, —OH, —OC1-6 alkyl, —ON(C1-6 alkyl)2, —N(C1-6 alkyl)2, —N(C1-6 alkyl)3+X?, —NH(C1-6 alkyl)2+X?, —NH2(C1-6 alkyl)+X?, —NH3+X?, —N(OC1-6 alkyl)(C1-6 alkyl), —N(OH)(C1-6 alkyl), —NH(OH), —SH, —SC1-6 alkyl, —SS(C1-6 alkyl), —C(?O)(C1-6 alkyl), —CO2H, —CO2(C1-6 alkyl), —OC(?O)(C1-6 alkyl), —OCO2(C1-6 alkyl), —C(?O)NH2, —C(?O)N(C1-6 alkyl)2, —OC(?O)NH(C1-6 alkyl), —NHC(?O)(C1-6 alkyl), —N(C1-6 alkyl)C(?O)(C1-6 alkyl), —NHCO2(C1-6 alkyl), —NHC(?O)N(C1-6 alkyl)2, —NHC(?O)NH(C1-6 alkyl), —NHC(?O)NH2, —C(?NH)O(C1-6 alkyl), —OC(?NH)(C1-6 alkyl), —OC(?NH)OC1-6 alkyl, —C(?NH)N(C1-6 alkyl)2, —C(?NH)NH(C1-6 alkyl), —C(?NH)NH2, —OC(?NH)N(C1-6 alkyl)2, —OC(NH)NH(C1-6 alkyl), —OC(NH)NH2, —NHC(NH)N(C1-6 alkyl)2, —NHC(?NH)NH2, —NHSO2(C1-6 alkyl), —SO2N(C1-6 alkyl)2, —SO2NH(C1-6 alkyl), —SO2NH2, —SO2C1-6 alkyl, —SO2OC1-6 alkyl, —OSO2C1-6 alkyl, —SOC1-6 alkyl, —Si(C1-6 alkyl)3, —OSi(C1-6 alkyl)3-C(?S)N(C1-6 alkyl)2, C(?S)NH(C1-6 alkyl), C(?S)NH2, —C(?O)S(C1-6 alkyl), —C(?S)SC1-6 alkyl, —SC(?S)SC1-6 alkyl, —P(?O)2(C1-6 alkyl), —P(?O)(C1-6 alkyl)2, —OP(?O)(C1-6 alkyl)2, —OP(?O)(OC1-6 alkyl)2, C1-6 alkyl, C1-6 perhaloalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 carbocyclyl, C6-10 aryl, 3-10 membered heterocyclyl, 5-10 membered heteroaryl; or two geminal Rgg substituents can be joined to form ?O or ?S; wherein X? is a counterion.

US Pat. No. 10,391,084

METHODS AND COMPOSITIONS TO TREAT CANCER

1. A method of treating a subject having a disorder selected from the group consisting of an MDK-expressing-lung cancer, and an MDK-expressing-renal cancer, comprising: administering to a subject in need thereof an effective amount of a compound of formula (I):
or a pharmaceutically acceptable salt thereof,
wherein:
R1 is hydrogen, —OCH3, —CH3, —CF3 or halogen;
R2 is hydrogen or chlorine;
R3 is hydrogen, chlorine or —CF3; and
R4 is

US Pat. No. 10,391,049

TOPICAL SKIN COMPOSITIONS FOR TREATING WRINKLES

Mary Kay Inc., Addison, ...

1. A method of treating a fine line or wrinkle in a person's skin, the method comprising topically applying to the fine line or wrinkle a composition comprising an effective amount of Commiphora mukul resin or an extract thereof that includes oleo gum resin, wherein topical application of the composition to the fine line or wrinkle reduces the appearance of the fine line or wrinkle.

US Pat. No. 10,391,030

RECEPTION, DRAINING AND TRANSFER OF A HIGH QUANTITY OF BIOPHARMACEUTICAL FLUID UNDER PRESSURE WITH A VIEW TO SUBSEQUENT TREATMENT

SARTORIUS STEDIM FMT SAS,...

1. A device for the reception and then the draining of a large amount of biopharmaceutical fluid, at least equal to about 10 liters, under controlled pressure by a laboratory which prepares pharmaceutical products, for the purposes of further treatment such as filtration, final formulation, and/or filling containers of smaller capacity, wherein the device comprises:an inner bag made of plastic, flexible and fluidtight, having an inner container intended and suitable for receiving a quantity at least equal to about 10 liters of biopharmaceutical fluid and provided with a filling port for supplying the biopharmaceutical fluid and a drain port for emptying the biopharmaceutical fluid, and connected in a fluidtight manner to the filling port and drain port, a filling tube having an inlet for filling the inner container with biopharmaceutical fluid, adapted to be connected to a filling line for the biopharmaceutical fluid, and a drain tube having an outlet for draining the inner container of biopharmaceutical fluid, adapted to be connected to a drain line for the biopharmaceutical fluid,
an outer container into which the inner bag is placed, a compression chamber being formed between the outer container and the inner bag for which the filling inlet and drain outlet are located externally to the outer container, a port for injecting pressurized draining gas into the compression chamber being provided on said outer container,
fluidtight passages through the outer container via the filling tube and drain tube,
an integrated means for bleeding the gas filling the filling line prior to filling with biopharmaceutical fluid, so that this gas does not enter the inner bag, and
the respective deformation capacities of the inner bag and outer container being chosen such that when injecting the pressurized draining gas into the compression chamber, the inner bag is compressed and the pressure causes the biopharmaceutical fluid contained therein to empty through the drain outlet, wherein:
the outer container comprises a fluidtight outer receptacle made of plastic, forming an outer chamber into which the inner bag is placed, defining the compression chamber, and comprising the injection port for the pressurized draining gas,
the filling tube and drain tube pass through the outer receptacle via fixed permanent connections, the filling inlet and drain outlet being located externally to the outer receptacle, and
the outer receptacle and the inner bag form a coherent whole that is disposable.

US Pat. No. 10,391,024

DEVICE FOR CREATING THE ILLUSION OF PENETRATION

THIKA HOLDINGS LLC, St. ...

1. A sex toy comprising:an elastic housing connected to a tip at a first end and a base at a second end; and
a spring arranged within the elastic housing with a first spring end engaged against the tip and a second spring end engaged against the base;
wherein (1) in an initial state, the spring is configured to be in an extended state, and in such initial state the sex toy has a first longitudinal length, and
(2) in a secondary state, the spring is configured to be compressed within the housing along a longitudinal axis (X) such that the elastic housing compresses and the sex toy is compressed to a second longitudinal length that is less than the first longitudinal length in response to the tip engaging against a user's body to thereby apply pressure to the sex toy.

US Pat. No. 10,391,016

MACHINE TO HUMAN INTERFACES FOR COMMUNICATION FROM A LOWER EXTREMITY ORTHOTIC

Ekso Bionics, Inc., Rich...

1. A lower extremity orthosis configured to be coupled to a person, the orthosis comprising:a torso link configured to be coupled to a torso of the person,
at least one leg link configured to be coupled to a leg of the person,
at least one actuator configured to shift the at least one leg link with respect to the torso link,
a plurality of sensors configured to measure at least one of an orientation and forces of the orthosis and the person,
a controller configured to receive signals from the plurality of sensors, estimate at least one feedback ready value based on signals from the plurality of sensors, and control the at least one actuator to assist a gait or movement of the person, and
at least one feedback system operated by the controller and configured to communicate the at least one feedback ready value to the person, whereby the orthosis provides the person with orthosis operational information not otherwise available to the person, wherein the at least one feedback system includes at least one of (1) at least one light corresponding to each of the at least one actuator, the at least one light indicating an effort being produced by the orthosis at that corresponding actuator, and (2) a display mounted in a field of view of the person, the display overlaying graphics so that the graphics indicate locations on a support surface.

US Pat. No. 10,391,014

SURGICAL POSITIONING SYSTEM

Allen Medical Systems, In...

1. A surgical positioning device for use with a patient, the surgical positioning device comprisinga flexible air impermeable shell having an interior region, the shell having an outer periphery defined by an upper edge, a lower edge and opposite lateral edges extending between the upper edge and the lower edge, the shell being shaped to underlie a patient's torso during surgery and to wrap around the patient's shoulders during surgery, and
a plurality of beads substantially filling the interior region of the shell and permitting the shell to be pliable prior to evacuation of air from the interior region so that the shell is able to be wrapped around portions of the patient, the shell rigidifying in response to air being evacuated from the interior region, wherein the shell has shoulder portions that wrap around the patient's shoulders, wherein the upper edge of the shell is shaped so that when the shell is lying flat, the shoulder portions extend in a longitudinal dimension of the surgical positioning device beyond a central region of the upper edge defined between the shoulder portions such that the surgical positioning device is devoid of any structure that extends in the longitudinal dimension beyond the shoulder portions.

US Pat. No. 10,391,013

POWERED AMBULANCE COT WITH AN AUTOMATED COT CONTROL SYSTEM

Ferno-Washington, Inc., ...

1. A powered ambulance cot for transporting a patient above a surface, comprising:a support frame for supporting the patient above the surface;
four legs, each leg having a wheel for supporting the cot on the surface;
a pair of actuators, each actuator interconnects the support frame and a respective pair of the legs and effects changes in position of the wheels of each respective pair of the legs relative to the support frame;
a motor controller which controls the pair of actuators individually to raise and lower the wheels of each respective pair of the legs with respect to the support frame according to a mode selection from a plurality of mode selections; and
a graphical user interface (GUI) controller which, via an electrically connected graphical user interface (GUI), receives an input of the mode selection from among the plurality of mode selections and outputs a matching image on the GUI of the selected mode.

US Pat. No. 10,391,010

SLEEP DISORDER TREATMENT DEVICES, SYSTEMS, AND METHODS

Hill-Rom Services, Inc., ...

1. A sleep disorder treatment system, comprising:a mattress may have a longitudinal length defined by a longitudinal axis of the mattress when the mattress is in its most horizontal position and a lateral width defined by a lateral axis of the mattress when the mattress is in its most horizontal position, wherein the mattress comprises:
a head section having a head support surface to support at least a portion of a person's head, wherein at least a portion of the head support surface is generally sloped in the lateral direction at an angle relative the lateral axis, wherein the angle of the head support surface is from about 10 degrees to about 30 degrees; and
a torso section having a torso support surface to support at least a portion of a person's torso, wherein the torso support surface is generally sloped in the lateral direction at an angle relative to the lateral axis, and wherein the torso support section comprises a cradle surface extending downwardly and laterally from near one side of the torso support section to an opposite side of the torso support section, the cradle surface being provided by a rigid curved plate embedded in foam at an upper region of the torso support section.

US Pat. No. 10,391,009

OPTIMIZATION OF THE OPERATION OF A PATIENT-SUPPORT APPARATUS BASED ON PATIENT RESPONSE

Hill-Rom Services, Inc., ...

1. A patient-support apparatus comprisinga plurality of bladders,
a plurality of pressure sensors coupled to the plurality of bladders and configured to produce pressure signals indicative of air pressure within the plurality of bladders, and
a controller in electrical communication with the plurality of pressure sensors, the controller configured to determine an expected first patient outcome associated with an expected position of a patient due to migration of the patient to a position near a foot end of the patient support apparatus over a time interval based on a patient-specific profile and an operating parameter of the patient-support apparatus and the controller is further configured to determine an actual first patient outcome associated with an actual first position of the patient due to migration of the patient toward a foot end of the patient support apparatus over a time interval and to adjust target pressures for the plurality of bladders based on a comparison of the actual first patient outcome and the expected first patient outcome.

US Pat. No. 10,391,008

PATIENT SUPPORT SYSTEM AND METHODS OF USE

Hill-Rom Services, Inc., ...

1. A patient support system comprisinga base including a lower frame, an upper frame mounted above the lower frame, a lift system configured to move the upper frame relative to the lower frame, and an obstruction sensor configured to detect the presence and the location of obstructions present between the lower frame and the upper frame,
and a control system including a user interface and a controller coupled to the obstruction sensor, the controller configured to activate one or more of fault indicators on the user interface based on inputs from the obstruction sensor included in the base, wherein each of the fault indicators activated is associated with one of a head end of the patient support system, a foot end of the patient support system, a left side of the patient support system, and a right side of the patient support system so that a caregiver can remove obstructions from specifically identified locations without visually inspecting between the lower frame and the upper frame,
wherein the user interface includes a graphic representation of the patient support system, fault indicators associated with the head end of the patient support system are arranged along a head end of the graphic representation of the patient support system, fault indicators associated with the foot end of the patient support system are arranged along a foot end of the graphic representation of the patient support system, fault indicators associated with the left side of the patient support system are arranged along a left side of the graphic representation of the patient support system, and fault indicators associated with the right side of the patient support system are arranged along a right side of the graphic representation of the patient support system.

US Pat. No. 10,390,997

MEDICINAL PRODUCT FOR THE CARE OF AN INDIVIDUAL

1. A medicinal product for care of an individual having an injury with a surface area, comprising:a carrier;
a first functional surface on said carrier configured to cover an area adjacent to the injury;
first stem parts projecting from said first functional surface and having free front-side ends forming adhesion parts adhereable on the individual or a second functional surface primarily by van der Waals forces;
a functional care surface on said carrier configured to be adhered on the surface area of the injury; and
second stem parts projecting from said functional care surface and having free front-side ends forming adhesion parts adhereable to the surface area of the injury primarily by van der Waals forces.

US Pat. No. 10,390,996

OPHTHALMIC RANGE FINDING

AMO Development, LLC, Sa...

1. A non-transitory machine-readable medium having machine-executable instructions configured to perform a method for analyzing an ophthalmic anatomy of a patient posterior to a cornea, the method comprising:scanning a focus of a femtosecond laser beam of a femtosecond laser along a path within the patient's eye, wherein at least a portion of the path is disposed posterior to the patient's cornea, and wherein the path includes a first location and a second location;
acquiring a first reflectance image associated with the focus disposed at the first location;
acquiring a second reflectance image associated with the focus disposed at the second location; and
determining the presence or absence of an ophthalmic anatomical feature of the eye based on a comparison between the first reflectance image and the second reflectance image by comparing a color, shape, or intensity of a focus spot in the first reflectance image respectively with a color, shape, or intensity of a focus spot in the second reflectance image.

US Pat. No. 10,390,993

DELIVERY SYSTEM AND METHOD OF USE FOR THE EYE

IVANTIS, INC., Irvine, C...

1. A method of maintaining an opening in a trabecular meshwork of a patient's eye to conduct fluid from an anterior chamber into Schlemm's canal of the eye, the method comprising:advancing an inserter device from the anterior chamber into the trabecular meshwork;
advancing a shaft distally within the inserter device against an implant within the inserter;
advancing the implant distally through an opening in a distal end of the inserter device;
pushing the distal end of the implant into and through the inner wall of Schlemm's canal to establish a passageway extending in a straight line from a proximal opening of the implant to a distal opening of the implant; and
conducting fluid from the anterior chamber through the implant into Schlemm's canal.

US Pat. No. 10,390,992

THERMAL CONTROL SYSTEM

Stryker Corporation, Kal...

1. A thermal control unit comprising:a first fluid outlet adapted to fluidly couple to a first fluid supply line;
a second fluid outlet adapted to fluidly couple to a second fluid supply line;
a first fluid inlet adapted to fluidly couple to a first fluid return line;
a second fluid inlet adapted to fluidly couple to a second fluid return line;
a heat exchanger;
a pump for circulating fluid from the first and second fluid inlets through the heat exchanger and to the first and second fluid outlets;
a sensing subsystem adapted to detect if the first fluid outlet becomes disconnected from the first fluid supply line and if the second fluid outlet becomes disconnected from the second fluid supply line; and
a controller in communication with the pump, the heat exchanger, and the sensing subsystem, the controller adapted to provide a first indication to a user if the first fluid outlet becomes disconnected from the first fluid supply line and to provide a second indication to the user if the second fluid outlet become disconnected from the second fluid supply line.

US Pat. No. 10,390,990

MANDIBULAR PROTRUSION DEVICE

Panthera Dental Inc., Qu...

1. A mandibular protrusion device comprising:a maxillary dental tray having a wall defining a dentition receiving cavity, the wall having an outer side;
a mandibular dental tray having a wall defining a dentition receiving cavity, the wall having an outer side; and
at least two lateral links each having an elongated portion with an anterior end, a posterior end opposed to the anterior end, a first side face and a second side face opposed to the first side face, the anterior end of each one of the at least two lateral links being removably engageable with the maxillary dental tray and the posterior end of each one of the at least two lateral links being removably engageable with the mandibular dental tray with the first side face of the elongated portion of the at least two lateral links facing the outer side of the wall of at least one of the maxillary and mandibular dental trays, the maxillary dental tray and the mandibular dental tray including female members and each one of the at least two lateral links including two male members protruding from the elongated portion with a first one of the male members protruding from the first side face of the elongated portion adjacent to the anterior end to engage the maxillary dental tray from the first side face and a second one of the male members protruding from the second side face of the elongated portion adjacent to the posterior end, to engage the mandibular dental tray from the second side face, the male members being complementary in shape with the female members and configured to be engageable and disengageable from one another in at least one engagement/disengagement configuration that is not reached when the device is worn or in normal use, the at least one engagement/disengagement configuration being reached by rotating one of the maxillary dental tray and the mandibular dental tray more than 90° with respect to a configuration where the maxillary dental tray and the mandibular dental tray are superposed.

US Pat. No. 10,390,981

IMPLANT DELIVERY DEVICE ADAPTED TO BE ATTACHED TO OR INTERCONNECTED WITH A CATHETER, CATHETER AND METHOD

Venus Medtech (Hangzhou) ...

1. An assembly having an inner space extending along a longitudinal direction thereof, the assembly comprising:a device including a lumen;
an implant attached to the device, wherein the implant comprises a heart valve;
a first folding means connected to the implant and adapted for folding or unfolding the implant, the first holding means having an end;
a second folding means having an end that is coupled to the end of the first folding means; and
a catheter detachably attached to or interconnected with the device via a snap-on connection, the catheter including a lumen,
wherein the inner space includes a first section and a second section next to the first section along the longitudinal direction of the assembly, the first section being defined by the lumen of the device and the second section being defined by the lumen of the catheter, and
wherein the first folding means extends at least partially in the first section of the inner space, and the second folding means extends at least partially in the second section of the inner space.

US Pat. No. 10,390,979

MANUFACTURING PROCESS FOR POLYMERIC STENTS

Advanced Cardiovascular S...

1. A method of fabricating a stent comprising:forming a polymer tube made of a biodegradable polymer,
wherein forming the polymer tube comprises forming an extruded polymer tube and quenching the extruded polymer tube from a first temperature, the first temperature being above a melting temperature of the biodegradable polymer, to a second temperature, the second temperature being below a glass transition temperature of the biodegradable polymer, such that the biodegradable polymer of the formed tube is an amorphous or substantially amorphous glassy polymer;
processing the tube to increase the crystallinity of the biodegradable polymer from amorphous or substantially amorphous to between 35% and 55%;
cutting a pattern in the processed tube to form a cylindrically-shaped scaffold, wherein the scaffold includes a pattern of interconnecting struts,
wherein the pattern comprises a plurality of cylindrical rings of struts and longitudinal linking struts connecting the rings,
wherein the rings include bending elements including struts that flex inward to allow crimping of the scaffold and flex outward to allow expansion of the scaffold,
wherein the scaffold is radially expandable in a blood vessel of a body and has adequate radial strength to hold open the blood vessel, and
wherein the stent comprises the scaffold.

US Pat. No. 10,390,978

HIGHLY FLEXIBLE STENT AND METHOD OF MANUFACTURE

1. An implantable prosthesis comprising:a continuous helical winding having a plurality of circumferential sections circumscribing a helical axis, which is cut by an orthogonal plane, from a first end to a second end to define a tube, the plurality of circumferential sections being spaced apart along the helical axis, each of the plurality of circumferential sections having a non-orthogonal helical angle relative to the helical axis;
at least one bridge configured to connect one circumferential section to an axially-spaced adjacent circumferential section, the at least one bridge extending along its entire length on a plane orthogonal to the helical axis;
at least one annular ring connected to one of the first and second ends of the continuous helical winding, the at least one annular ring orthogonal to the helical axis; and
at least one marker having a first end connected to the at least one annular ring, and a second end connected to the continuous helical winding,
wherein the implantable prosthesis is operable from a contracted state to an expanded state and in the contracted state the at least one bridge creates a circumferential offset between adjacent circumferential sections that when measured in the plane orthogonal to the helical axis is equal to the length of the at least one bridge and in the expanded state the at least one bridge maintains the circumferential off-set.

US Pat. No. 10,390,977

ENDOVASCULAR IMPLANT

Intact Vascular, Inc., W...

1. A self-expanding intravascular implant comprising:a proximal undulating ring on a proximal side of the intravascular implant comprising a plurality of proximal struts, the plurality of proximal struts comprising a plurality of first proximal struts and a plurality of second proximal struts, wherein each first proximal strut of the plurality of first proximal struts is connected to at least one second proximal strut of the plurality of second proximal struts, wherein a proximal end of each first proximal strut of the plurality of first proximal struts is connected to a proximal end of a second proximal strut of the plurality of second proximal struts to form a plurality of first proximal apices and a distal end of each first proximal strut of the plurality of first proximal struts is connected to a distal end of a second proximal strut of the plurality of second proximal struts to form a plurality of first distal apices, wherein at least one first proximal apex of the plurality of first proximal apices defines a proximal end of the intravascular implant;
a distal undulating ring on a distal side of the intravascular implant comprising a plurality of distal struts, the plurality of distal struts comprising a plurality of first distal struts and a plurality of second distal struts, wherein each first distal strut of the plurality of first distal struts is connected to at least one second distal strut of the plurality of second distal struts, wherein a distal end of each first distal strut of the plurality of first distal struts is connected to a distal end of a second distal strut of the plurality of second distal struts to form a plurality of second distal apices and a proximal end of each first distal strut of the plurality of first distal struts is connected to a proximal end of a second distal strut of the plurality of second distal struts to form a plurality of second proximal apices, wherein at least one second distal apex of the plurality of second distal apices defines a distal end of the intravascular implant;
a plurality of bridge members each located between the proximal undulating ring and the distal undulating ring and each connecting one first distal apex of the plurality of first distal apices to one second proximal apex of the plurality of second proximal apices;
wherein the intravascular implant has a compression force curve being a measure of the amount of radial compression force required to compress the intravascular implant along a range of outer diameters, and has an expansion force curve being a measure of the amount of radial expansion force exerted by the intravascular implant when the intravascular implant self-expands along the range of outer diameters, wherein the range of outer diameters is at least about 2 mm and a change in radial force along the expansion force curve is no more than about 3 Newtons (N) along the range of outer diameters.

US Pat. No. 10,390,976

LINER FOR ORTHOPEDIC OR PROSTHETIC DEVICE

OSSUR ICELAND EHF, Reyja...

1. A liner for an orthopedic device, comprising:a core formed from a porous and compressible open-celled polyurethane foam, the core having first and second surfaces;
a first layer formed from an aqueous-based polyurethane emulsion and located along the first surface of the core;
a second layer formed from a hook receivable material and has a first surface located directly adjacent to the second surface of the core;
a polymeric film extending over a second surface of the second layer opposite the first surface of the second layer;
wherein the core has greater rigidity than the first layer, both the core and the first layer are arranged for transfer of air and vapor through a combined thickness;
wherein the polymeric film defines at least one opening exposing the second layer.

US Pat. No. 10,390,969

BI-DIRECTIONAL FIXATING TRANSVERTEBRAL BODY SCREWS AND POSTERIOR CERVICAL AND LUMBAR INTERARTICULATING JOINT CALIBRATED STAPLING DEVICES FOR SPINAL FUSION

Moskowitz Family LLC, Ro...

1. A system to provide fusion of a first vertebral body to a second vertebral body via biological bone fusion and screw fusion, the system comprising:an intervertebral cage comprising a top portion and a bottom portion wherein the top portion comprises first and second projections that extend outward in opposite directions to engage slots defined in the bottom portion so as to operably connect the top portion to the bottom portion, wherein the top portion and the bottom portion combine to form a top wall, a bottom wall, a first sidewall and a second sidewall, wherein the top wall is formed at least partially by the top portion and wherein the first sidewall, the second sidewall, and the bottom wall are formed at least partially by the bottom portion, and wherein the intervertebral cage defines:
at least one open space capable of receiving bone filling for biological bone fusion,
a first internal screw guide having a first entry opening and a first exit opening, the first entry opening formed in a top surface of the top portion at the top wall and the first exit opening formed at least partially in a bottom surface of the top portion at the top wall and at least partially in a first side surface of the top portion at the top wall,
a second internal screw guide having a second entry opening and a second exit opening, the second entry opening formed in the top surface of the top portion at the top wall and the second exit opening formed at least partially in the bottom surface of the top portion at the top wall and at least partially in a second side surface of the top portion at the top wall, wherein the first internal screw guide and the second internal screw guide are angled to orient screw members bi-directionally,
an indentation extending into the top surface of the top portion between the first internal screw guide and the second internal screw guide at an angle that is substantially perpendicular to the top surface, wherein the indentation is defined by first and second parallel indentation sides and third and fourth parallel indentation sides that are perpendicular to the first and second parallel indentation sides, and wherein the indentation is positioned along a centerline axis of the intervertebral cage that bisects the top surface, and
a circular top hole extending into the top surface of the top portion between the first internal screw guide and the second internal screw guide at an angle that is substantially perpendicular to the top surface, wherein the circular top hole is positioned along the centerline axis of the intervertebral cage that bisects the top surface;
a first screw having a first screw head defining a first head indentation shaped for receiving a tool and a first threaded body that is sized and configured to be inserted through the first internal screw guide at a first angle so the first screw extends from the intervertebral cage into a first vertebral body adjacent the intervertebral cage when inserted in a disc space; and
a second screw having a second screw head defining a second head indentation shaped for receiving the tool and a second threaded body that is sized and configured to be inserted through the second internal screw guide at a second angle different than the first angle so the first screw extends from the intervertebral cage into a second vertebral body adjacent the intervertebral cage when inserted in the disc space.

US Pat. No. 10,390,968

DEVICE FOR SPINAL SURGERY, CORRESPONDING GUIDE SLEEVE AND KIT WITH GUIDE SLEEVE

JOIMAX GMBH, Karlsruhe (...

1. A guide sleeve, for spinal surgery that forms a part of a kit, the guide sleeve comprising a non-cylindrical jacket, the non-cylindrical jacket comprising narrow sides and two broad sides, the two broad sides being opposite each other, the two broad sides having a width greater than a width of the narrow sides, one of the broad sides being flat, another one of the broad sides being convexly bent outwards, wherein a radius of curvature of a transition between one of the broad sides and one of the narrow sides is between 3 mm and 4.5 mm.

US Pat. No. 10,390,964

VARIABLE LORDOTIC INTERBODY SPACER

Globus Medical, Inc., Au...

1. An apparatus for enabling a spinal fusion treatment and including a variable lordotic interbody spacer, the apparatus comprising:a face plate having a front surface and a rear surface, the face plate further having at least one actuation channel;
superior and inferior endplates, each of the endplates having first and second endplate arms coupled by an endplate base, each endplate arm coupled to the rear surface of the face plate via a hinge opposite from the base, and each endplate arm having a ramp recess on a top surface and a bottom surface;
an actuation frame positioned between the superior endplate and the inferior endplate, the actuation frame having first and second frame arms coupled by a frame base, each frame arm having an actuation ramp pin on a top surface and on a bottom surface fitted to a corresponding ramp recess, the actuation frame further including a receptacle formed at the inside of the frame base between each frame arm; and
an actuation screw having a head, body and threaded end, the actuation screw body passing through the actuation channel, the head retained at the front surface and the threaded end threadably coupled to the receptacle of the actuation frame, wherein, when operated, the actuation screw moves the actuation frame between the superior endplate and the inferior endplate to adjust an angle formed there between, and wherein the actuation screw is configured to be retained in the face plate by a screw plate retainer fastened to the front surface of the face plate, wherein the screw plate retainer is configured to allow rotation of the actuation screw within the face plate while otherwise preventing the actuation screw from changing position relative to the face plate.

US Pat. No. 10,390,957

DEVICE FOR REPAIRING A HUMAN OR ANIMAL JOINT

SPINEWELDING AG, Schlier...

1. A device for treating a human or animal joint, the joint comprising two articulating surfaces and the device comprising:two articulating portions capable of at least limited articulation relative to each other and being equipped for being fixed one in each one of the articulating surfaces with the aid of a material having thermoplastic properties and vibration energy, wherein the material having thermoplastic properties is arranged on outer sides of each articulating portion,
a temporal connector portion being removably arranged between the two articulating portions, wherein the temporal connector portion, when arranged between the two articulating portions, connects the two articulating portions to form a rigid, non-articulating entity constituting one piece at least during an implantation procedure, said temporal connector portion being configured to be removed separately from said two articulating portions after having connected the two articulating portions at least for the time of the implantation procedure,
and an interface portion that is arranged between inner sides of the articulating portions, wherein the interface portion is elastic and fixed to each one of the inner sides of the two articulating portions and wherein the temporal connector portion is a spreader that is clamped between the inner sides of the articulating portions and retained in a clamped position by elasticity of the interface portion.

US Pat. No. 10,390,955

BONE IMPLANTS

ENGAGE MEDICAL HOLDINGS, ...

1. A bone implant, comprising:a first bone-contacting surface;
a second bone-contacting surface opposite the first bone-contacting surface;
a proximal side;
a distal side, wherein the first bone-contacting surface and the second bone-contacting surface diverge away from each other toward the proximal side of the bone implant and converge together toward the distal side of the bone implant;
a first protrusion;
a second protrusion;
a third protrusion intermediate the first protrusion and the second protrusion;
an intermediate portion intermediate the first protrusion and the second protrusion, wherein the first protrusion and the second protrusion protrude away from the intermediate portion toward the distal side of the bone implant;
a first recess intermediate the first protrusion and the second protrusion, wherein the first recess is substantially wider than the first protrusion and the second protrusion; and
a second recess intermediate the first protrusion and the third protrusion.

US Pat. No. 10,390,953

METHODS AND DEVICES FOR REDUCING PARAVALVULAR LEAKAGE

Cardiac Dimensions Pty. L...

1. A method of reducing paravalvular leakage associated with a replacement mitral valve, comprising:monitoring for paravalvular leakage between a replacement mitral valve and tissue proximate the mitral valve annulus;
if paravalvular leakage is observed, deploying a tissue reshaping device solely within a coronary sinus;
intravascularly remodeling coronary sinus tissue with the tissue reshaping device deployed solely within the coronary sinus to cause the remodeling of at least one of mitral valve annulus tissue, at least one mitral valve leaflet, and left atrium tissue in an attempt to reduce the paravalvular leakage; and
monitoring for a reduction in paravalvular leakage after the remodeling step.

US Pat. No. 10,390,952

PROSTHETIC VALVE WITH FLEXIBLE TISSUE ANCHOR PORTIONS

CARDIOVALVE LTD., Or Yeh...

1. An expandable prosthetic valve for implantation within a native mitral valve, the prosthetic valve comprising:an expandable annular valve body;
a plurality of ventricular anchoring legs, each ventricular anchoring leg configured to extend radially outward from the expandable annular valve body to respective terminal leg ends; and
a plurality of atrial anchoring arms, each atrial anchoring arm configured to extend radially outward from the expandable annular valve body,
wherein the expandable prosthetic valve is configured to assume:
a radially compressed state in which the prosthetic valve is configured to be contained at least partially within a prosthetic valve delivery device, and
a radially expanded state in which the expandable prosthetic valve is configured to be anchored within the native mitral valve,
wherein at least one atrial anchoring arm includes:
a rigid portion,
a flexible portion including a structure with multiple curves,
a first opening situated between the structure with multiple curves and a terminal end of the at least one atrial anchoring arm, and
a second opening situated between the structure with multiple curves and a location of connection between the at least one atrial anchoring arm and the expandable annular valve body,
wherein the structure with multiple curves does not extend to the terminal end of the at least one atrial anchoring arm, and
wherein when the expandable prosthetic valve is in the radially expanded state, the at least one atrial anchoring arm is configured to be arranged such that a part of the flexible portion situated outside a circumference defined by the terminal leg ends has a greater length than a part of the flexible portion situated inside the circumference defined by the terminal leg ends.

US Pat. No. 10,390,948

LEAFLET-CUFF ATTACHMENTS FOR PROSTHETIC HEART VALVE

St. Jude Medical, Cardiol...

1. A prosthetic heart valve, comprising:a stent having a collapsed condition and an expanded condition, the stent having a plurality of commissure features;
a valve assembly secured to the stent, the valve assembly including a plurality of leaflets secured to the commissure features and a cuff, each of the leaflets having a free edge, and a second edge opposite the free edge;
a reinforcement radially disposed between the stent and the cuff, the reinforcement being adjacent the second edge of each of the leaflets;
a first reverse-running stitch having an inner portion at least partially disposed on a first side of a first leaflet of the plurality of leaflets, and an outer portion at least partially disposed on a second side of the first leaflet; and
a second stitch that pierces through the first leaflet, the cuff above the reinforcement, and the cuff below the reinforcement such that at least one loop is formed around the reinforcement.

US Pat. No. 10,390,947

MEDICAL VALVE IMPLANT FOR IMPLANTATION IN AN ANIMAL BODY AND/OR HUMAN BODY

Biotronik AG, Buelach (C...

1. A medical valve implant for implantation in an animal body and/or human body, comprising:an implant structure configured as a medical heart valve; and
a base body that includes a collar extending in a circumferential direction around the implant structure and configured to radially expand, wherein the collar includes a first cell structure composed of a plurality of cells forming an inner cross section of the base body that is matched to an outer cross section of the implant structure and wherein the cells of the first cell structure are shaped to facilitate alignment of the valve prosthesis with a direction of blood flow, characterized in that the collar includes one or more second cell structures, wherein one of the one or more second cell structures is fastened to an inner contour of a cell of the first cell structure at two fastening points and is preloaded to move from a position that follows the inner contour of the cell to a position that extends radially outward relative to the cell of the first cell structure during expansion.

US Pat. No. 10,390,946

METHOD FOR THE PREPARATION OF BIOLOGICAL TISSUE FOR DRY USE IN AN IMPLANT

Biotronik AG, Buelach (C...

1. A method of preparing biological tissue for use as a component of a heart valve prosthesis comprising pretreating the tissue, and stabilizing the pretreated tissue, characterized in that, the step of pretreating the tissue comprises crosslinking the tissue with an aldehyde-containing solvent, wherein the aldehyde is glutaraldehyde or formaldehyde; and the step of stabilizing the pretreated tissue comprises exposing the tissue to three solutions for dimensional and structural stabilization, wherein a first solution contains polyethylene glycol having a mean molecular weight between 200 g/mol and 400 g/mol, a second solution contains glycerol, and a third solution contains polyethylene glycol having a mean molecular weight between 1,000 g/mol and 6,000 g/mol, wherein the tissue is exposed to the first and second solutions before the third solution.

US Pat. No. 10,390,944

BRAIDED SUPPORT STRUCTURE

HLT, Inc., Maple Grove, ...

1. A braided tubular medical implant comprising:a braided tubular structure having a first configuration and a second configuration wherein the first configuration is an elongated, unfolded configuration and the second configuration is a deployed, folded configuration;
wherein said braided tubular structure includes:
at least one circumferential preformed fold area having wires intersecting at a first braid angle;
a preformed circumferential fold located within said circumferential preformed fold area;
at least one body area adjacent said circumferential preformed fold area in which said wires intersect at a second braid angle;
wherein said first braid angle is not equal to said second braid angle; and,
wherein the first braid angle being not equal to the second braid angle at least partially effects folding the braided tubular structure to form said second configuration.

US Pat. No. 10,390,943

DOUBLE ORIFICE DEVICE FOR TRANSCATHETER MITRAL VALVE REPLACEMENT

EVALVE, INC., Santa Clar...

1. An orifice valve device for attachment to a mitral valve defining at least two orifices, the device comprising:an anchoring and manifold assembly coupleable to a delivery catheter;
a peripheral ring anchoring system fluidly communicating with and secured to the anchoring and manifold assembly, the peripheral ring anchoring system including:
two expandable anchoring rings, wherein each expandable anchoring ring can be expanded within a respective orifice of the mitral valve so as to surround a perimeter of the respective orifice and form a corresponding opening, the two expandable anchoring rings being in fluid communication and disposed on opposite sides of the anchoring and manifold assembly whereby the anchoring and manifold assembly forms a portion of a perimeter of each of the corresponding openings;
two helical sutures, each of the two helical sutures being helically disposeable about a respective one of the two expandable anchoring rings to secure the respective one of the two expandable anchoring rings to leaflet tissue around the perimeter of the respective orifice of the mitral valve; and
two trap door valves, each trap door valve hingedly secured within a respective opening formed by the peripheral ring anchoring system, each trap door valve comprising:
a trap door body that selectively seals against a respective one of the two expandable anchoring rings extending around the perimeter of a respective orifice of the mitral valve during a systole portion of a cardiac cycle, the trap door body selectively unsealing relative to the one of the two expandable anchoring rings so as to open the corresponding opening and thus the respective orifice of the mitral valve, during a diastole portion of the cardiac cycle.

US Pat. No. 10,390,939

MICRO-INCISION IOL AND POSITIONING OF THE IOL IN THE EYE

AMO GRONINGEN B.V., Gron...

1. An intraocular lens comprising: an optic disposed about an optical axis, the optic having an anterior surface and a posterior surface; at least two anterior projections coupled to and extending radially from the optic; and at least two posterior projections adjacent to the at least two anterior projections, wherein the at least two posterior projections are coupled to and extends radially from the optic, wherein the anterior and posterior projections are resiliently biased such that distal ends of the anterior projections and the posterior projections can be moved away from and toward each other, and wherein, when implanted, the distal ends of the at least two anterior projections and the at least two posterior projections are configured to grip an outside surface and an inside surface adjacent to a capsulorhexis on an anterior portion of an evacuated capsular bag.

US Pat. No. 10,390,932

STENT GRAFT WITH INTERNAL TUNNELS AND FENESTRATIONS AND METHODS OF USE

Bolton Medical, Inc., Su...

1. A thoraco-abdominal branch graft prosthesis, comprising:a) a main graft component having a luminal wall defining an open proximal end, an open distal end opposite the open proximal end, a main lumen extending from the open proximal end to the open distal end, and at least one main graft wall fenestration; and
b) at least one tunnel graft component having a tunnel graft luminal wall defining, at least in part, an open tunnel graft proximal end, an open tunnel graft distal end opposite the open tunnel graft proximal end, a tunnel graft lumen extending from the open tunnel graft proximal end to the open tunnel graft distal end, and at least one tunnel graft fenestration in the tunnel graft wall, wherein the tunnel graft component is within the main graft lumen and a major longitudinal axis of the tunnel graft lumen that is parallel to and spaced apart from a major longitudinal axis of the main lumen, and wherein the wall of the tunnel graft component is fixed to the wall of the main graft component, whereby the fenestration of the tunnel graft wall is aligned with the fenestration of the luminal wall.

US Pat. No. 10,390,930

METHOD FOR AORTIC BRANCHED VESSEL REPAIR

Bolton Medical, Inc., Su...

1. A method for implanting a prosthesis, comprising the steps of:a) delivering an aortic graft assembly that includes a tubular aortic component through an aorta to an aneurysm site of a patient, the tubular aortic component defining a tunnel lumen and having a proximal end and a distal end connected by a wall, the wall defining a wall aperture that is between the proximal end and the distal end, the wall aperture having a proximal end and a distal end, the proximal end of the wall aperture including an first plane extending perpendicular to a major longitudinal axis of the tubular aortic component when viewed orthogonally to the major longitudinal axis, the tubular aortic component being radially and releasably constrained by a distal clasp at a distal end of an outer control tube of a delivery device, and releasably attached by a retention component to a proximal clasp at the outer control tube proximal to the proximal clasp, the tubular aortic component further supported by a control catheter of the delivery device extending within the outer control tube, the aortic graft assembly further including a tunnel graft extending from the wall aperture and within the tunnel lumen of the tubular aortic component toward the proximal end of the tubular aortic component, wherein the length of the proximal end of the wall aperture in the first plane is greater than the diameter of the tunnel graft lumen in a second plane extending orthogonally to the major longitudinal axis at a point proximal to the proximal end of the wall aperture;
b) aligning the wall aperture over at least one vessel ostium at the aneurysm site of the patient; and
c) retracting the outer control tube, thereby releasing the tubular aortic component from the distal and proximal clasps, thereby deploying the tubular aortic component at the aneurysm site in the patient.

US Pat. No. 10,390,929

METHODS OF SELF-ALIGNING STENT GRAFTS

Bolton Medical, Inc., Su...

1. A method for automatic endovascular alignment of a prosthesis in a curved implantation site of a vessel, which comprises:providing a prosthesis delivery system with a distal handle, a longitudinally movable distal delivery assembly that includes an apex release lumen and a longitudinally movable guidewire lumen having a pre-curved distal portion within the apex release lumen and rotationally connected to the distal delivery assembly, the distal delivery assembly and the guidewire lumen being together rotatably mounted to the distal handle;
loading the prosthesis in the distal delivery assembly, the prosthesis including a longitudinal support that is fixed to the prosthesis at a superior longitudinal line of the guidewire lumen, to thereby form a loaded distal delivery assembly, whereby advancement of the loaded distal delivery assembly into the curved implantation site will cause axial rotation of the guidewire lumen and the prosthesis together about a longitudinal axis of the distal delivery assembly, and alignment of the longitudinal support with a superior longitudinal line of the curved implantation site;
positioning a guidewire at least into the curved implantation site of the vessel;
threading the guidewire lumen over the guidewire along with the loaded distal delivery assembly;
advancing the guidewire lumen and the loaded distal delivery assembly along the guidewire toward the curved implantation site; and
further advancing the guidewire lumen, the loaded distal delivery assembly, and the prosthesis that is loaded into the distal delivery assembly, along the guidewire and into the curved implantation site whereby advancement of the curved distal portion of the guidewire lumen into the curved implantation site causes rotation of the guidewire lumen, the loaded distal delivery assembly- and the prosthesis to rotationally align together about the longitudinal axis of the distal delivery assembly, to thereby align of the longitudinal support with the superior longitudinal line of the curved implantation site.

US Pat. No. 10,390,925

MIGRATION RESISTANT EMBOLIC FILTER

C.R. Bard, Inc., Murray ...

1. An embolic filter, comprising:a) a head having a proximal end, a distal end having a first position, and a filter central longitudinal axis;
b) a plurality of appendages that include straight leg appendages and bent leg appendages, each of said plurality of appendages extending distally from the first position on the distal end of the head, said plurality of appendages including a first plurality of appendages providing a distal appendage end with a curved anchor, said curved anchor configured to engage an inner wall of a vein at a location spaced distally of the head and prevent the embolic filter from migrating in a cranial direction;
c) the said plurality of appendages including a second plurality of appendages that are said straight leg appendages, each having a straight leg central longitudinal axis, each straight leg appendage extending distally from the head at said first position, wherein each appendage of the second plurality has a distal most end, said distal most end having a caudal anchor located distally of the head and joined to the straight leg appendage, each said caudal anchor having a vein engagement surface configured to engage an inner wall of a vein at a location spaced distally of the head to prevent the embolic filter from migrating in a caudal direction;
d) wherein said straight leg central longitudinal axis intersects said vein engagement surface;
e) wherein the curved anchor is of a different configuration as compared to the caudal anchor of the straight legs;
f) wherein each said caudal anchor has a distal most tip, said vein engagement surface located proximally of said distal most tip and wherein there is a taper between the distal most tip and the said straight leg appendage proximally of said distal most tip, wherein said vein engagement surface is located at said taper and forms an obtuse angle with said straight leg appendage central axis;
g) wherein one or more of the appendages of the first plurality are longer than one or more of the appendages of the second plurality;
h) the filter having a pre-deployment position that aligns all of the appendages together distally of the head and next to said filter central longitudinal axis;
i) the filter having a deployed position wherein all of the appendages are spaced radially away from said filter central longitudinal axis, and wherein said vein engagement surface is configured to abut the vein inner wall; and
j) wherein in both the pre-deployment and deployed positions the said curved anchors and caudal anchors are closer to each other and closer to said filter central longitudinal axis than to the head.

US Pat. No. 10,390,921

URINE FLOW CONTROL SYSTEM AND A MAGNETIC ACTUATOR DEVICE

MAGCATH APS, Copenhagen ...

1. A urine flow control system, comprising:a catheter device configured for insertion into a urethra, the catheter device including (1) a proximal end portion and an opposite distal end portion, (2) a conduit between the proximal end portion and the distal end portion, the conduit having a urine inlet opening at the proximal end portion and a urine outlet opening at the distal end portion, (3) a valve seat at the distal end portion, and (4) a magnet configured as a valve body that is magnetically biased toward a closed position against the valve seat to block an outflow of urine from the catheter device through the urine outlet opening; and
a magnetic actuator device configured for magnetically displacing the valve body from the valve seat to permit the outflow of urine from the catheter device through the urine outlet opening, wherein the magnetic actuator device comprises:
a housing with (1) a first open end removably coupled to the distal end portion of the catheter device so as to receive the outflow of urine from the catheter device, and (2) a second open end configured for discharging the urine from the housing; and
an actuator element at the first open end of the housing and comprising a body of a magnetically attractive material, wherein the actuator element is operable to move the valve body toward an open position when the distal end portion of the catheter device is coupled to the first open end of the housing.

US Pat. No. 10,390,914

METHOD FOR PROCESSING PREFABRICATED PROSTHETIC TEETH

Kulzer GmbH, Hanau (DE)

1. A method for processing prosthetic teeth for the production of a full denture or at least a partial denture with at least two prosthetic teeth comprising the following method steps:(a) inserting at least two prefabricated prosthetic teeth having coronal sides and basal sides into an elastic mold, wherein the coronal sides of the prosthetic teeth are inserted into recesses in the elastic mold,
(b) attaching a clamping device to the elastic mold if a clamping device is not already attached to the elastic mold, and after inserting the prosthetic teeth into the elastic mold, applying a mechanical pressure to the elastic mold with the clamping device, wherein the pressure exerts a force onto the prosthetic teeth inserted into the elastic mold via the elastic mold and the prosthetic teeth are thereby affixed in the elastic mold,
(c) positioning and aligning the prosthetic teeth in the elastic mold in such a manner in relation to each other that the prosthetic teeth comprise a desired position and desired alignment in relation to each other which they should have in the partial denture to be produced or full denture to be produced,
(d) affixing the elastic mold with the clamping device and prosthetic teeth in a defined position in a holder of a CAM device for removing material of the prosthetic teeth with a CAM method,
(e) basally ablating at least one of the prosthetic teeth affixed in the elastic mold with the CAM method,
(f) connecting the prosthetic teeth affixed in the elastic mold to a denture base on their respective basal sides after at least one of the prosthetic teeth has been basally ablated, and
(g) following connecting the prosthetic teeth to the denture base, releasing the elastic mold from the prosthetic teeth.

US Pat. No. 10,390,912

THERMOFORMING AIDS AND METHODS

Loren S. Adell, Sunnyval...

1. A method of using a thermoforming aid to form a thermoformable sheet onto an object to create an impression of the object in the thermoformable sheet, the method comprising:placing a thermoforming aid which comprises a thermoformable sheet having an inherent tendency to curl and a curl-resistant element which is in surface-to-surface contact with a surface of the thermoformable sheet to prevent the thermoformable sheet from curling, on an open-center platen of a thermoforming machine by adhering a perimeter margin of a lower surface of one of the thermoformable sheet and the curl-resistant element to the platen;
placing an object underneath the thermoformable sheet; and
operating, the thermoforming machine to heat the thermoformable sheet and cause the heated thermoformable sheet to form onto an object and create an impression of at least a portion of the object in the thermoformable sheet,
in which adhering a perimeter margin of a lower surface of one of the thermoformable sheet and the curl-resistant element to the platen comprises adhering a perimeter margin of a lower surface of the thermoformable sheet to the platen, and
in which the adhering the perimeter margin of a lower surface of the thermoformable sheet to the platen comprises adhesively adhering a perimeter margin of a lower surface of the thermoformable sheet to the platen using adhesive which is on the perimeter margin of the lower surface of the thermoformable sheet.

US Pat. No. 10,390,903

ILLUMINATED APPARATUS WITH TELESCOPING FOR ELECTROCAUTERY DEVICES AND METHOD OF USE

1. An illuminating device for use with an electrocautery device comprising:a mounting portion connected to a telescoping portion, the mounting portion having a distal end and a proximal end, and a length extending therebetween;
a mount disposed between the distal end and the proximal end of the mounting portion, the mount defining a space to receive a body of the electrocautery device, and the mount further comprising at least one projection for frictional contact with the body of the electrocautery device on a bottom side of the mount, the space to receive the body of the electrocautery device further comprising an opening to allow one or more controls on the body of the electrocautery device to be accessed when the body of the electrocautery device is located within the mount;
the mounting portion further comprising a connector disposed on the proximal end, the connector attached to a proximal end of a hollow portion, the hollow portion located within the mounting portion and extending from the proximal end to the distal end of the mounting portion, the hollow portion being above the mount;
the telescoping portion defining a void for an electrocautery blade of the electrocautery device to pass therethrough;
the telescoping portion having a distal end and a proximal end, and a light source disposed on the distal end of the telescoping portion, the telescoping portion configured to telescope relative to the mounting portion from a first, retracted position wherein the proximal end of the telescoping portion abuts the distal end of the mounting portion, to a second, extended position wherein there is a space between the proximal end of the telescoping portion and the distal end of the mounting portion;
the distal end of the telescoping portion further comprising a smoke evacuation void positioned above the void for the electrocautery blade of the electrocautery device, the smoke evacuation void connected to a tube for smoke evacuation, the tube for smoke evacuation passing through the hollow portion of the mounting portion, such that the telescoping portion comprising the void for the electrocautery blade of the electrocautery device telescopes relative to the electrocautery blade of the electrocautery device, and wherein the smoke evacuation void and the light source telescope together relative to the electrocautery blade.

US Pat. No. 10,390,902

SYSTEM AND METHOD FOR INSTRUMENT TRACKING

HCL TECHNOLOGIES LIMITED,...

1. A device for tracking one or more instrument in a surgical kit, the device comprising:a magnetic sensor, wherein the magnetic sensor is configured to transmit one or more signals upon detecting a change in a state of a surgical kit, wherein the state is one of an open state and a closed state;
one or more of a load cell and a Piezo sensor, wherein the one or more of the load cell and the Piezo sensor are activated based on the one or more signals; and
a machine control unit coupled to the magnetic sensor and the one or more of the load cell and the Piezo sensor, wherein the machine control unit is capable of executing instructions to perform steps of:
receiving the one or more signals from the magnetic sensor;
activating the one or more of the load cell and the Piezo sensor based on the one or more signals;
receiving data from the one or more of the load cell and the Piezo sensor, wherein the data is associated with one or more instruments within the surgical kit;
computing a current state associated with each of the one or more instruments based on the data, and historical data, wherein the current state is one of: instrument present, instrument absent, and instrument present in reduced quantity;
transmitting the current state of the surgical kit, the current state associated with each of the one or more instruments and a location co-ordinate of the surgical kit via a communication channel based on a signal strength of the communication channel; and
deactivating the one or more of the load cell and the Piezo sensor, thereby tracking one or more instruments in the surgical kit.

US Pat. No. 10,390,901

OCULAR INJECTION KIT, PACKAGING, AND METHODS OF USE

CLEARSIDE BIOMEDICAL, INC...

1. An apparatus, comprising:a first tray member having a plurality of walls that define a first volume and an opening that provides access to the first volume;
a second tray member having a plurality of walls that define a second volume and an opening that provides access to the second volume, a wall from the plurality of walls of the second tray member including a retainer extending from the wall from the plurality of walls of the second tray member and configured to retain at least a portion of a medicament delivery device within the second volume, the opening of the second tray member providing removal access of the medicament delivery device from within the second volume,
in a first configuration, the second tray member is disposed within the first volume of the first tray member such that access to the medicament delivery device within the second volume is inhibited by a wall from the plurality of walls of the first tray member,
in a second configuration, the second tray member is physically separate from the first tray member to allow access to the medicament delivery device within the second volume; and
a cover member coupled to the first tray member about the opening, the cover member configured to maintain sterility of the first volume.

US Pat. No. 10,390,890

NAVIGATIONAL FEEDBACK FOR INTRAOPERATIVE WAYPOINT

SYNAPTIVE MEDICAL (BARBAD...

1. A method of providing navigational feedback during a surgical procedure by way of a processor, the method comprising:providing an augmented reality display, displayed on an augmented reality display device coupled with the processor, for viewing a three-dimensional (3D) position and an orientation of a surgical tool in a surgical field during the surgical procedure, the position and the orientation of the surgical tool being tracked by a medical navigation system coupled with the processor, and the augmented reality display comprising a virtual representation of the surgical tool superimposed on a live, real-time image of the surgical field;
automatically intraoperatively creating a waypoint and storing, in a memory coupled to the processor, a selected intraoperative start time, a selected intraoperative end time, a selected intraoperative 3D position, and a selected intraoperative orientation of the surgical tool as a stored start time, a stored end time, a stored position, and a stored orientation of the waypoint, the stored position comprising x, y, and z coordinates, and the stored orientation comprising pitch, yaw, and roll;
providing feedback to indicate the stored start time, the stored end time, the stored position, and the stored orientation of the waypoint, the feedback comprising information to guide return of the surgical tool to the waypoint after the surgical tool has been moved from the selected intraoperative position and the selected intraoperative orientation; and
when the surgical tool has returned to the stored position and the stored orientation of the waypoint prior to the stored end time, providing further feedback indicating a successful return of the surgical tool to the waypoint.

US Pat. No. 10,390,886

IMAGE-BASED PEDICLE SCREW POSITIONING

Siemens Healthcare GmbH, ...

1. One or more non-transitory computer readable media embodying a program of instructions executable by machine to perform operations for pedicle screw positioning, the operations comprising:receiving image data of at least a portion of a spine;
segmenting at least one vertebra of interest in the image data to generate segmentation results;
generating a vertebral distance map based on the segmentation results;
determining two pedicle regions within the segmented vertebra of interest based on the vertebral distance map;
determining one or more safe regions within the segmented vertebra of interest by performing a thresholding algorithm based on the vertebral distance map;
generating two optimal insertion paths within the one or more safe regions, wherein the two optimal insertion paths pass through respective centers of the pedicle regions; and
displaying the two optimal insertion paths for pedicle screw positioning.

US Pat. No. 10,390,885

METHOD AND SYSTEM FOR DETERMINING TREATMENTS BY MODIFYING PATIENT-SPECIFIC GEOMETRICAL MODELS

HeartFlow, Inc., Redwood...

1. A method for planning treatment for arterial stenotic lesions by processing patient-specific images of a patient, comprising:identifying a set of stenotic lesions in a patient's coronary arteries from medical image data of the patient;
generating a plurality of treatment options for the set of stenotic lesions, wherein each of the plurality of treatment options corresponds to a stenting configuration in which one or more of the stenotic lesions are stented;
calculating, for each of the plurality of treatment options, predicted hemodynamic metrics for the set of stenotic lesions resulting from the stenting configuration corresponding to that treatment option; and
recommending a treatment option from the plurality of treatment options based on the predicted hemodynamic metrics for the set of stenotic lesions calculated for each of the plurality of treatment options, and based on a number of stents in the stenting configuration corresponding to each of the plurality of treatment options.

US Pat. No. 10,390,884

METHODS AND TEMPLATES FOR SHAPING PATIENT-SPECIFIC ANATOMICAL-FIXATION IMPLANTS

DePuy Synthes Products, I...

1. A method of determining a shape for an anatomical implant, the method comprising steps of:positioning an anatomical implant template along at least one anatomical body, the anatomical implant template defining first and second opposed terminal ends, and including a flexible body that extends between the first and second opposed terminal ends, the flexible body having an external surface at least partially covered by a protective covering, and an internal surface opposite the external surface, the internal surface defining a channel therethrough that supports at least one sensor therein;
bending the template from a first configuration, whereby the anatomical implant template extends along a first path from the first terminal end to the second terminal end, to a second configuration, whereby the anatomical implant template extends from the first terminal end to the second terminal end along a second path different from the first path, wherein when the anatomical implant template is in the second configuration, the anatomical implant template conforms more closely to a curvature of the at least one anatomical body as compared to when the template is in the first configuration; and
causing the at least one sensor to generate a signal having information from which a shape of the anatomical implant template in the second configuration can be ascertained; and
causing a transmitter supported by the flexible body to wirelessly communicate the signal to a computing device.

US Pat. No. 10,390,883

LASER-DIRECTED MICROCAVITATION

1. A method for the generation, in a medium having a liquid phase, of microcavitation bubbles of maximum volume controlled over at least twice a threshold radiant exposure, comprising:using a laser system comprising a pulse shaping mechanism, generating one or more laser pulses, each laser pulse having a pulse duration between 1 ns and 5000 ns and an energy selected to deliver a radiant exposure sufficient to initiate microcavitation within the medium during the pulse duration of each laser pulse, the pulse shaping mechanism imposing on each laser pulse a tailored amplitude profile over said pulse duration selected to deliver a greater quantity of energy to the medium during an end portion of the pulse duration than during a beginning portion thereof; and
irradiating the medium with the laser pulses.

US Pat. No. 10,390,882

FLOW RATE MONITOR FOR FLUID COOLED MICROWAVE ABLATION PROBE

Covidien LP, Mansfield, ...

1. A microwave ablation system comprising:a power source configured to generate microwave energy;
an antenna assembly coupled to the power source;
a coolant source coupled to the antenna assembly and configured to supply a fluid through a fluid path to the antenna assembly;
a sensor coupled to the fluid path and configured to generate an electrical signal indicative of a flow of the fluid through the fluid path;
a signal processing circuit coupled to the sensor and configured to detect at least one peak of the electrical signal being indicative of an interruption in the flow of the fluid through the fluid path; and
a controller configured to automatically adjust output of the microwave energy from the power source based on the detected peak.

US Pat. No. 10,390,880

CATHETER WITH IRRIGATED TIP ELECTRODE WITH POROUS SUBSTRATE AND HIGH DENSITY SURFACE MICRO-ELECTRODES

Biosense Webster (Israel)...

1. A catheter comprising:an elongated catheter body;
a distal electrode member distal of the catheter body and having a porous substrate and a plurality of surface electrodes on portions of an outer surface of the porous substrate, the porous substrate having an interior chamber adapted to receive conductive fluid;
a plurality of lead traces on the outer surface of the porous substrate, each of the plurality of lead traces connected to a respective one of the plurality of surface electrodes, at least one of the plurality of lead traces having a portion extending underneath at least one other of the plurality of surface electrodes, the portion of the at least one of the plurality of lead traces extending underneath the at least one other of the plurality of surface electrodes sitting in a groove on the outer surface of the porous substrate; and
a chamber lead wire having a distal portion extending into the interior chamber, the chamber lead wire adapted to electrify the conductive fluid in the interior chamber,
the porous substrate being configured to pass the conductive fluid from the interior chamber to the outer surface of the porous substrate.

US Pat. No. 10,390,879

DEVICES AND METHODS FOR ABLATION OF TISSUE

Mayo Foundation for Medic...

1. A catheter-based medical device for treating a tissue, the device comprising:an elongate catheter shaft including a liquid delivery lumen therethrough;
a balloon device disposed at a distal end portion of said catheter shaft, said balloon device comprising a bulbous-shaped proximal portion and a generally cylindrical-shaped distal portion when said balloon is inflated, said bulbous-shaped proximal portion in fluid communication with said generally cylindrical-shaped distal portion, said balloon device comprising an outer surface and an inner surface, said inner surface defining an interior space of said balloon device, said balloon device in fluid communication with said liquid delivery lumen, said balloon device comprising a porous or microporous material that is arranged to transmit a liquid through said porous or microporous material;
one or more electrodes that are disposed on or within said balloon device and are arranged to deliver energy to said tissue; and
a filter device that is reconfigurable between a collapsed low-profile delivery configuration and a deployed configuration in which said filter device is radially expanded in comparison to said collapsed low-profile delivery configuration, wherein said bulbous-shaped proximal portion of said balloon device is inside said filter device while said filter device is configured in said deployed configuration.

US Pat. No. 10,390,878

MEDICAL DEVICE AND MEDICAL SYSTEM

OLYMPUS CORPORATION, Tok...

1. A medical device comprising:an insertion portion which is capable of being inserted into a body; and
a driving mechanism which is coupled to the insertion portion,
wherein the insertion portion includes:
a treatment portion which is configured to perform a treatment on a treatment target portion;
a joint portion which is configured to be capable of supporting the treatment portion and changing a direction of the treatment portion;
a storage portion which is configured in the joint portion and capable of internally accommodating the treatment portion; and
a driving force transmission portion which is connected to the joint portion and configured to transmit a driving force for changing the direction of the treatment portion to the joint portion,
wherein the driving mechanism includes a driving force generation portion which is configured to generate the driving force connected to the driving force transmission portion,
wherein the treatment portion enters and exits the storage portion by the driving force transmitted from the driving force generation portion to the joint portion through the driving force transmission portion,
wherein the treatment portion includes an incision electrode which is configured to receive a supply of a high-frequency current to incise living tissue,
wherein the joint portion includes a switching mechanism which is configured to switch a conductive state of the high-frequency current for the incision electrode,
wherein the insertion portion includes a power supplying cable which is connected to the switching mechanism and from which the high-frequency current is applied,
wherein the driving mechanism includes a plug which is connected to the power supplying cable and connectable to a high-frequency power supply device, and
wherein the switching mechanism cuts off a current applied to the power supplying cable and the incision electrode when the incision electrode is positioned inside the storage portion, and electrically connects the power supplying cable and the incision electrode when the incision electrode is positioned outside the storage portion.

US Pat. No. 10,390,876

PLANAR TRANSFORMERS HAVING REDUCED TERMINATION LOSSES

COVIDIEN LP, Mansfield, ...

1. An electrosurgical generator for generating electrosurgical energy, the generator including a planar transformer, the planar transformer comprising:a plurality of circuit layers stacked together in a first direction, the plurality of circuit layers including at least one terminal for outputting electrosurgical energy, and further including a first circuit layer and a second circuit layer, the first and second circuit layers each including an electrically conductive trace forming at least one of primary windings of the planar transformer, a first termination portion, and a second termination portion, the first termination portion and the second termination portion defining a gap therebetween,
wherein the plurality of stacked circuit layers includes a means for spreading current flowing through the first and second termination portions of the first and second circuit layers,
wherein the plurality of stacked circuit layers further includes a plurality of secondary circuit layers different from the first and second circuit layers, a portion of each having an electrically conductive trace that forms a grounded portion coupled to ground and a second portion of each having an electrically conductive trace that forms a secondary winding of the planar transformer, and
wherein the first and second gaps of the first and second circuit layers are immediately adjacent to the grounded portion of a corresponding secondary circuit layer along the first direction.

US Pat. No. 10,390,873

SYSTEMS AND METHODS FOR PROSTATE TREATMENT

Boston Scientific Scimed,...

1. A method for treating benign prostatic hyperplasia (BPH), comprising:introducing an energy delivery member transurethrally into a transition zone tissue adjacent a patient's prostatic urethra; and
injecting a condensable vapor media from the energy delivery member into the transition zone tissue at a depth of less than 12 mm outward from the patient's prostatic urethra so as to confine the condensable vapor media in the transition zone tissue and to ablate the transition zone tissue adjacent to and less than 12 mm outward from the prostatic urethra, wherein the condensable vapor media is configured to apply energy ranging from 1 to 40 cal/sec to the transition zone tissue.

US Pat. No. 10,390,872

MULTIFUNCTIONAL ABLATION DEVICE

Medtronic CryoCath LP, T...

1. A method of treating cardiac tissue, the method comprising:positioning an expandable element of a medical device proximate a pulmonary vein and expanding the expandable element in the pulmonary vein to substantially occlude the pulmonary vein;
positioning a substantially linear thermal segment of the medical device proximate an atrial wall, the thermal segment being more flexible than at least one medical device segment adjacent to the thermal segment;
applying a compressive force from a proximal portion of the medical device to the thermal segment, the compressive force causing the thermal segment to deflect towards the atrial wall; and
circulating cryogenic fluid through a first fluid flow path in fluid communication with the expandable element to ablate the pulmonary vein.

US Pat. No. 10,390,866

VARIABLE ANGLE LOCKING IMPLANT

1. A variable angle locking implant comprising:a bone plate having a lower surface;
an upper surface; and
at least one opening extending from the lower surface to the upper surface along an axis, the at least one opening having an inner surface consisting of a plurality of upper fins and a plurality of lower fins, the plurality of upper fins being circumferentially disposed about the inner surface, the plurality of circumferentially disposed upper fins defining an upper, circumferential edge including a series of concave and convex surfaces, the plurality of lower fins being circumferentially disposed about the inner surface, the plurality of circumferentially disposed lower fins defining a lower, circumferential edge including a series of concave and convex surfaces, wherein the plurality of upper fins are positioned closer to the upper surface of the bone plate and the plurality of lower fins are positioned closer to the lower surface of the bone plate; and
wherein at least one of the plurality of upper fins and the plurality of lower fins cooperate with a head of a bone fastener; and
wherein the plurality of upper and lower fins each have a tapered surface extending from the inner surface of the at least one opening to a terminal end of the fin.

US Pat. No. 10,390,865

ORTHOPEDIC LOCKING SCREW FOR AN ORTHOPEDIC FASTENING SYSTEM AND METHOD OF SECURING AN ORTHOPEDIC LOCKING SCREW

Stryker European Holdings...

1. An orthopedic fastening system, comprising:an orthopedic implant comprising a bore; and
an orthopedic locking screw configured to be retained inside the bore, the orthopedic locking screw comprising:
a shaft extending along an axis between a first and a second end, the first end sized to be received in the bore;
a drive member disposed at the second end;
a casing secured to and rotationally fixed around an outer surface of the shaft in a non-secured state of the screw, wherein the casing is formed of a plastically deformable material, the casing having a first end proximate the first end of the shaft and a second end proximate the second end of the shaft; and
a forward external thread disposed on the shaft between the first end of the casing and the first end of the shaft,
wherein the casing has an outer cross-sectional width (W1) that is larger than a smallest inside cross-sectional width of the bore and forms a press-fit pressure against the bore when operably disposed in the bore, and
wherein the casing comprises a deformable thread disposed along an outer surface of the casing, wherein the deformable thread is an external thread that is configured to engage an internal thread feature of the bore.

US Pat. No. 10,390,862

SPINAL CORRECTION SYSTEM AND METHOD

Warsaw Orthopedic, Inc., ...

1. A spinal construct comprising:a longitudinal element;
a first arm connected with the longitudinal element;
a first body connected with the first arm such that the first body is rotatable relative to the first arm, the first arm including a lock to fix the first body relative to the first arm, the lock of the first body including a collar and a shaft that support the first arm, the collar defining an opening and the shaft defining an opening, the openings being aligned to support the first arm;
a second arm connected with the longitudinal element and axially translatable relative to the first arm, the second arm including a housing;
a second body connected with the second arm such that the second body is rotatable relative to the second arm, the second arm including a lock to fix the second body relative to the second arm; and
a locking element pivotably coupled to the housing and configured to move between a first orientation in which the second arm is translatable along the longitudinal element and a second orientation in which the second arm is prevented from translating along the longitudinal element.

US Pat. No. 10,390,859

SYSTEM FOR CORRECTING BONES

UMC UTRECHT HOLDING B.V.,...

1. A system for correcting bones, comprising:at least a first pin which is configured to be connected to the bone at a first location;
at least a second pin which is configured to be connected to the bone at a second location at a distance from the first location;
a fixation member which is coupled rigidly to the first and second pins for the purpose of fixing the mutual distance between the pins during a hardening phase, and which is coupled flexibly to the first and the second pins during a correction phase;
at least a first annular fixation member which is connected to the first pin and at least a second annular fixation member which is connected to the second pin so that the mutual distance and/or orientation between the first and second annular fixation members can be adjusted while the fixation member remains coupled to the first pin and the second pin during the correction phase,
wherein the fixation member is configured to remain attached to the first pin and the second pin when the first annular fixation member and the second annular fixation member are removed during the hardening phase, and
wherein the first pin and the second pin are configured to remain connected to the bone at the first location and the second location, respectively, throughout the correction phase and the hardening phase.

US Pat. No. 10,390,856

SURGICAL IMPLANTATION INSTRUMENT

MINIPUMPS, LLC, Pasadena...

1. An instrument facilitating surgical implantation of an implantable device having two opposed surface portions at least one of which has a curved surface contour, the instrument comprising:first and second forceps arms each having first and second ends, the arms being joined at the first ends thereof and arranged to oppose but permit resisted compression of the arms toward each other into a closed position from an open position, wherein compression of the arms toward each other into the closed position forces the second ends of the arms toward each other;
a first-arm head member, having a first length defined by a distal end and a proximal end thereof, located at the second end of the first arm; and
a second-arm head member, having a second length defined by a distal end and a proximal end thereof, located at the second end of the second arm,
wherein:
(i) the head members are flared outwardly so as to be angled away from each other along the entire first and second lengths thereof at least in the open position relative to an axis running between and coplanar with the arms,
(ii) each of the head members defines an interior surface, the interior surfaces being opposed to each other and differently shaped to releasably engage the implantable device without damage thereto upon compression of the arms into the closed position,
(iii) the interior surface of at least one of the head members has a curved portion complementary to the curved surface contour of the implantable device whereby closure of the arms causes the head members to opposedly engage the surface contour of the implantable device to prevent release thereof from the instrument in the closed position, and
(iv) the differently shaped interior surfaces mate with different surface contours of the implantable device.

US Pat. No. 10,390,854

ROTATABLE MEDICAL DEVICE

Boston Scientific Scimed,...

1. A medical device, comprising:a tubular member having a lumen;
a shaft extending through the lumen; and
a handle at a proximal end of the tubular member, wherein the handle includes:
a base coupled to the shaft,
a first hub member coupled to the base,
a second hub member coupled to the first hub member, and
a cap coupled to the second hub member,
wherein each of the first hub member and the second hub member extends into a cavity defined by the cap, and
wherein engagement between the cap and the second hub member, due to movement of the cap onto the second hub member, compresses the second hub member onto the first hub member, causing an increase in frictional engagement between the second hub member and the first hub member.

US Pat. No. 10,390,853

ROBOTICALLY CONTROLLING MECHANICAL ADVANTAGE GRIPPING

Covidien LP, Mansfield, ...

1. An end effector of a surgical tool, the end effector comprising:a housing having proximal and distal ends, the housing defining a longitudinal axis that extends through the proximal and distal ends;
a jaw support shaft mounted to the housing and defining a pivot axis that extends therethrough;
a pair of jaw members supported on the jaw support shaft and being pivotable about the pivot axis, each of the pair of jaw members defining a support shaft slot therethrough and including a pulley pin and a jaw pin extending therefrom, each of the pair of jaw members defining a jaw pin slot adapted to receive an opposing one of the jaw pins of the pair of jaw members; and
a pair of cam pulleys mounted to the jaw support shaft and coupled to the pair of jaw members, the pair of cam pulleys being rotatable about the pivot axis to pivot the pair of jaw members about the jaw support shaft, the pair of cam pulleys movable relative to the pair of jaw members.

US Pat. No. 10,390,852

MINIMALLY INVASIVE SURGICAL ASSEMBLY AND METHODS

TELEFLEX MEDICAL INCORPOR...

1. A surgical device, comprising:a) an elongated needle body defining an interior lumen extending longitudinally therethrough, the elongated needle body having a sharpened distal tip portion;
b) an assembly operatively associated with the interior lumen of the elongated needle body, the assembly having:
i) a shaft having an outer surface profile corresponding to an inner surface of the interior lumen of the elongated needle body; and
ii) a pair of arms extending distally from the shaft, each of the pair of arms comprising a rod and a grasper, wherein the graspers are biased radially outward from the longitudinal axis of the shaft, and one arm of the pair of arms is in a fixed axial alignment with the sharpened distal tip portion of the elongated needle body such that the pair of arms act as an obturator relative to the sharpened distal tip portion of the elongated needle body to guard the elongated needle body from causing accidental needle tip trauma; and
c) a handle portion operatively attached to a proximal end portions of both the elongated needle body and the shaft such that the elongated needle body and the shaft can be rotated independent of the handle portion, the handle portion further configured and adapted to advance and retract the elongated needle body over the pair of arms and the shaft, the elongated needle body being biased towards a retracted position to further guard the elongated needle body from accidental needle trauma,
wherein the pair of arms are formed as electrically isolated conductors, and
wherein the rods are each encircled by a plastic overwrap, the plastic overwrap having a shape corresponding to a respective outer surface of the rods to maintain the fixed axial alignment.

US Pat. No. 10,390,851

RETRIEVAL DEVICES AND RELATED METHODS OF USE

Boston Scientific Scimed,...

1. A retrieval device having a contracted state and an expanded state, comprising:a sheath;
at least three support members each having a first portion with a first cross-sectional shape being distal to a second portion with a second cross-sectional shape different from the first cross-sectional shape, a proximal end fixed to the sheath, and a distal end movable relative to the sheath; and
at least three movable members each having a pair of ends movable relative to the support members, each movable member extending through a lumen of one support member of the at least three support members and through a lumen of a different support member of the at least three support members, wherein the first portion is sized to permit a plurality of degrees of freedom to each movable member; and
wherein the second portion is sized to permit a reduced number of degrees of freedom to each movable member so as to prevent a first movable member from twisting about another moveable member of the at least three moveable members.

US Pat. No. 10,390,849

CAPTURE ASSEMBLY AND METHOD

1. An assembly for removing obstructive material from a body vessel or cavity, comprising:an elongate outer member and an elongate inner member, each extending from a proximal end to a distal end and including a first lumen therethrough, wherein a maximum annular gap between an inner surface of the elongate outer member and an outer surface of the elongate inner member is 0.1 mm,
the first lumen of the elongate inner member having an aspiration entrance at the distal end of the elongate inner member and defined by a wall, the wall including a plurality of orifices adjacent and proximal to the entrance,
the elongate inner member movable along a common longitudinal axis relative to the elongate outer member such that the plurality of orifices is extendable beyond, and retractable within, the distal end of the elongate outer member to break down the obstructive material, wherein the elongate outer member does not include a wall orifice;
the elongate outer member including a second lumen positioned about its outer surface, the second lumen providing a longitudinal slot or channel adapted for a guidewire;
an aspirator in flow communication with the elongate inner member for drawing the obstructive material through the aspiration entrance of the first lumen of the elongate inner member; and
a valve manifold comprising a first port, the first port including a one-way valve in communication with the first lumen of the elongate inner member and allowing flow in a distal-to-proximal direction toward the aspirator.

US Pat. No. 10,390,848

SNARE

Medical Device Technologi...

1. A snare for snaring an article, comprising: first, second and third loops, each of the first, second and third loops having a proximal end portion and a distal end portion, and a mid-portion therebetween, and being formed by spaced apart first and second sides connected together at the distal end portion of the loop, the distal end portions being positioned forward of the proximal end portions, the first side of the first loop arranged to cross over and be positioned inside of the second side of the second loop at a first crossover point, the first side of the second loop arranged to cross over and be positioned inside of the second side of the third loop at a second crossover point, and the first side of the third loop and arranged to cross over and be positioned inside of the second side of the first loop at a third crossover point, each of the loops being disconnected from the adjacent loops at the location of crossing, the distal end portions of the first, second and third loops being disconnected from each other, the first, second and third loops being movable between an open position whereat the first, second and third loops extend laterally outwardly with their distal end portions in an open position and define a space therebetween for receiving at least a portion of the article therein, and a collapsed position whereat the first, second and third loops are positioned laterally inwardly from their open position with their distal end portions in a closed position closer together than when in the open position, and the mid-portions of the first, second and third loops being disconnected from each other to permit independent movement of each as the first, second and third loops are moved between the open and closed positions.

US Pat. No. 10,390,847

SYSTEMS AND METHODS FOR ASPIRATING FROM A BODY LUMEN

Silk Road Medical, Inc., ...

1. A device for aspirating fluid from a body lumen, comprising:an internal syringe barrel member defining a chamber configured to contain fluid, the chamber having an opening through which fluid can pass;
a plunger movably positioned at least partially within the chamber, the plunger including a plunger seal;
an external syringe barrel connected to the plunger, wherein the internal syringe barrel is slidably positioned inside the external syringe barrel, wherein the plunger and the external syringe barrel collectively form a body that can slide relative to the internal syringe barrel;
first and second finger elements extending outward from a proximal end of the internal syringe barrel;
third and fourth finger elements extending outward from a distal end of the external syringe barrel;
wherein movement of the first and second finger elements toward the third and fourth finger elements causes relative movement between the plunger seal and the chamber so as to aspirate fluid into the chamber;
a locking mechanism movable between a first state and a second state, wherein the locking mechanism locks a position of the plunger seal relative to chamber when the locking mechanism is in the first state, and the locking mechanism permits relative movement of the plunger seal relative to chamber when the locking mechanism is in the second state.

US Pat. No. 10,390,846

APPARATUS FOR AND METHOD OF PROVIDING A HIP REPLACEMENT

MicroPort Orthopedics Hol...

1. A surgical method, comprising:inserting a positioning member of a first tool into a first incision, the first tool including an extension portion that extends from the positioning member at a first end to a holder at a second end;
using the holder to mark a location for a second incision while the positioning member is disposed within an acetabulum;
making the second incision based on the location identified by the holder; and
inserting a cannula through the holder and into the second incision.

US Pat. No. 10,390,845

PATIENT-SPECIFIC SHOULDER GUIDE

Biomet Manufacturing, LLC...

1. An orthopedic device for a shoulder joint comprising:a patient-specific alignment guide including:
a cap having a three-dimensional engagement surface customized in a pre-operative plan by computer imaging to closely mate and conform to a corresponding humeral head of a proximal humerus of a patient, a periphery of the cap being configured to surround an anatomic neck of the humeral head;
an element defining a longitudinal guiding bore configured for guiding an alignment pin at a patient-specific position and an orientation determined in the pre-operative plan;
an orientation feature on the cap, the orientation feature configured to orient the cap relative to the humeral head when the orientation feature is aligned with a landmark of the proximal humerus; and
a resection formation comprising a slot provided at the periphery of the cap, the slot being configured for guiding a resection of the anatomic neck of the humeral head.

US Pat. No. 10,390,844

TARGETING ADJUSTMENT

Stryker European Holdings...

1. A targeting system for a bore in a distal end portion of an intramedullary nail, comprising: a distal targeting arm with a first end being configured to be coupled to a trailing end of an intramedullary nail; an adjusting device, the adjusting device being configured to be coupled to the distal targeting arm, wherein the adjusting device comprises an adjusting element and a nail follower including two targeting holes each being configured to receive a sleeve assembly; and wherein the adjusting element engages the nail follower and is configured to adjust the position of the nail follower so that the targeting holes correspond to respective locking holes at a leading end of the intramedullary nail, when the nail is bent, wherein the adjusting element comprises two screws wherein a first screw includes a first thread with a first pitch and a second screw includes a second thread with a second pitch, wherein the first pitch differs from the second pitch, and wherein the first and second screws are coupled by a gear with a gear ratio of 1:1.

US Pat. No. 10,390,843

TRAJECTORY AND AIMING GUIDE FOR USE WITH FLUOROSCOPY

Dartmouth-Hitchcock Clini...

1. A system for a trajectory and aiming guide for use with fluoroscopy comprising:a ring holder comprising:
a plurality of connecting arms;
a radiolucent base; and
a central axle extending from the radiolucent base;
a first rotatable disk rotatable relative to the ring holder, the first rotatable disk comprising:
a first radiolucent disk ring with a central cutout, wherein the central axle extends through the central cutout, the first radiolucent disk ring comprising an embedded array of a plurality of radiopaque wires; and
a second rotatable disk comprising:
a second radiolucent disk ring with a central cutout, wherein the central axle extends through the central cutout, the second radiolucent disk ring comprising an embedded array of a plurality of radiopaque wires.

US Pat. No. 10,390,842

GEARED INSTRUMENT FOR TIBIAL STEM REAMING OR REMOVAL

WRIGHT MEDICAL TECHNOLOGY...

1. A method, comprising:forming an anterior incision to access an ankle joint;
locating a housing of an instrument in the ankle joint, the instrument comprising a translation gear disposed within the housing and a stem coupled to the translation gear;
coupling a modular head to the stem;
inserting a handle into the housing and coupling the handle to the translation gear such that the translation gear translates rotation of the handle about a first axis to rotation of the stem about a second axis; and
rotating the handle about the first axis to rotate the modular head about the second axis to perform a first surgical procedure.

US Pat. No. 10,390,841

CONTROL OF MOTOR VELOCITY OF A SURGICAL STAPLING AND CUTTING INSTRUMENT BASED ON ANGLE OF ARTICULATION

ETHICON LLC, Guaynabo, P...

1. A surgical instrument, comprising:a motor operable to translate an articulation member along a distance from a proximal position to a distal position, wherein the articulation member is translatable relative to an end effector the distance from the proximal position to the distal position, wherein the translation of the articulation member causes an articulation joint to articulate, and wherein the motor comprises an engaged condition, a disengaged condition, and a hold condition;
a control circuit coupled to the motor;
a position sensor coupled to the control circuit, wherein the position sensor is configured to detect a position of the articulation member along at least a portion of the distance; and
wherein the control circuit is configured to:
receive a position input from the position sensor indicative of an articulation position of the articulation member;
identify a predetermined threshold corresponding to the articulation position of the articulation member;
determine a control action of the motor, when the motor is in the disengaged condition, in response to a movement of the articulation member that exceeds the predetermined threshold; and
control the movement of the articulation member, wherein controlling the movement of the articulation member comprises engaging the motor to the hold condition.

US Pat. No. 10,390,840

ACCESSORY FOR OSTEOTOMY

Biomet Manufacturing, LLC...

1. A set suitable for use in a bone-shortening osteotomy of a predetermined distance, the set comprising:an implant including a distal segment and a proximal segment, wherein the distal segment comprises at least two distal threaded holes and wherein the proximal segment comprises at least two proximal threaded holes; and
a plurality of accessories, wherein each accessory is adapted for use in a bone-shortening osteotomy of one of a plurality of predetermined distances, each accessory comprising successively a first segment, a second segment and a third segment, wherein the first segment comprises first threaded holes and wherein the third segment comprises second threaded holes, and wherein the second segment comprises two guides which are each adapted to guide a saw blade such that the bone-shortening osteotomy of the predetermined distance can be performed via the two guides, wherein the first threaded holes and the second threaded holes respectively correspond to the at least two distal threaded holes and the at least two proximal threaded holes, with an intermediate spacing between first and second threaded holes which is equal to the sum of said predetermined distance and a corresponding intermediate spacing between distal and proximal threaded holes, and wherein the first segment and the third segment have the same shape, at least at the position of the threaded holes, as respectively the distal segment and proximal segment.

US Pat. No. 10,390,839

APPARATUS AND MANUFACTURING MEANS FOR AN ADJUSTABLE COMPRESSION WRISTBAND

Semler Technologies, Inc....

1. A method of constructing a strap of a vascular compression wristband that includes at least one inflatable balloon, the balloon and strap each having a top side and a bottom side, wherein:a) said method includes the steps of i) forming at least one attachment weld at or near perimeter edges to join the top side and bottom side of the balloon, the top side composed of at least two layers of an elastic, flexible plastic material, and the bottom side composed of one layer of an elastic, flexible plastic material, said at least one attachment weld being generally continuous except where necessary to insert a hollow tube, the at least two layers of the top side further having at least one attachment weld formed between their perimeter edges on a portion of the top side, and ii) forming an attachment weld to connect the hollow tube into the balloon between its top side and bottom side; and,
b) the at least one attachment weld formed between the perimeter edges on a portion of the top side of the balloon more particularly forms lines for the purpose of facilitating placement of the wristband and providing reinforcement against stretching during deployment wherein the lines include a first line running proximally-distally and another non-parallel line crossing the first line, the intersection of said lines having an enlarged area.

US Pat. No. 10,390,838

TUNED STRENGTH CHRONIC OBSTRUCTIVE PULMONARY DISEASE TREATMENT

PneumRx, Inc., Santa Cla...

1. A method for treating a lung of a patient with chronic obstructive pulmonary disease, the method comprising:determining a regional tissue characteristic of at least a portion of lung tissue of the patient; and
selecting between a first coil having a first austenite final tuning and a second coil having a second austenite final tuning different than the first austenite final tuning based on the determined regional tissue characteristic of the portion of lung tissue, wherein the first austenite final tuning is characterized by a first transition temperature that is higher than a second transition temperature of the second austenite final tuning.

US Pat. No. 10,390,836

METHOD AND SYSTEM FOR TREATING ANEURYSMS

Endologix, Inc., Irvine,...

1. A system for treating an aneurysm comprising:a first catheter and a second catheter each catheter having an endobag comprising a double-walled filling structure with an aneurysm conforming outer wall and a blood transit lumen creating an inner wall surrounding an endoframe releasably coupled to the respective catheter,
each of the first and second catheters includes an endobag pressurization piping having one end releasably coupled to the respective endobag and an inner lumen in communication with the respective endobag with the other end of the respective endobag pressurization piping in communication with an endobag pressurization tubing outside the respective catheter,
each of the first and second catheters includes a balloon on which the respective endoframe is mounted so as to expand the endoframe when inflated, each balloon being in communication with an endoframe pressurization tubing outside of the respective catheter, and
each of the first and second catheters comprises a guidewire lumen in communication with a guidewire lumen pressurization tubing extending outside the respective catheter; and
a manifold console having two endobag pressurization tubing outlet ports, two endoframe pressurization tubing outlet ports, and two guidewire lumen pressurization outlet ports, the two endobag pressurization tubing outlet ports being connectable to the corresponding ends of the endobag pressurization tubing of the endobags of the first and second catheters, the two endoframe pressurization tubing outlet ports being connectable to the corresponding ends of the endoframe pressurization tubing of the first and second catheters, and the two guidewire lumen pressurization outlet ports being connectable to the corresponding ends of the guidewire lumen pressurization tubing of the first and second catheters;
the manifold console further having a series of inlet ports including a first inlet port in communication with the two endobag pressurization tubing outlet ports, a second inlet port in communication with the two endoframe pressurization tubing outlet ports, and a third inlet port in communication with the two guidewire lumen pressurization outlet ports,
the manifold console being configured so that when the endobag pressurization and endoframe pressurization tubing ends from the first and the second catheters are connected to the corresponding manifold console outlet ports pressurization of the first inlet port equally pressurizes corresponding endobag pressurization tubing to both the first and second catheters simultaneously and pressurization of the second inlet port equally pressurizes corresponding endoframe pressurization tubing to both the first catheter and the second catheter simultaneously.

US Pat. No. 10,390,834

CIRCULAR SURGICAL STAPLERS WITH ISOLATING SLEEVES STORED INSIDE ANVIL

Ethicon LLC, San Lorenzo...

1. A circular stapling instrument comprising:a) an anvil having a tissue facing end and an opposite distal end;
the anvil having a peripheral staple bending zone and a coaxial circular knife recess on said tissue facing end;
the anvil having a circumferential recess formed inside said anvil, with a circumferential entrance into said circumferential recess positioned on said tissue facing end coaxially between the staple bending zone and the circular knife recess;
b) a cylindrical stapling head mounted on a support shaft, said stapling head containing a concentric knife and a plurality of deployable staples in concentric arrays on a tissue facing side of said stapling head;
c) a moveable shaft connecting the anvil and stapling head; and
d) an elongated hollow anvil sleeve having a flange at a proximal end thereof,
said anvil sleeve open at a distal end thereof and at the proximal end thereof;
said flange positioned on the tissue facing end of the anvil against said staple bending zone;
wherein said distal end of said anvil sleeve is releasably disposed in said circumferential recess,
wherein a circular separation wall is formed on said tissue facing end of said anvil coaxially between the circumferential entrance and the circular knife recess.

US Pat. No. 10,390,833

TISSUE ANCHOR FOR SECURING TISSUE LAYERS

BOSTON SCIENTIFIC SCIMED,...

1. A medical device for placement across aligned penetrations in adjacent tissue of a first luminal region of a body and a second region of the body to form a flow path therebetween, comprising:an anchor comprising a woven filament braid with a central lumen having a first length in a radially constrained configuration, the anchor transitionable between the radially constrained configuration and a preformed configuration,
the preformed configuration comprising a middle segment of the central lumen having a second length and a proximal end and a distal end of the central lumen flaring radially outward to form only one proximal flange structure along the proximal end and only one distal flange structure along the distal end,
wherein the middle segment includes a substantially constant diameter which extends substantially an entire length between the proximal and distal flange structures,
wherein the proximal flange structure includes a single tissue apposing surface adjacent to the middle segment and the distal flange structure includes a single tissue apposing surface adjacent to the middle segment to appose the adjacent tissue of the first luminal region and the second region along the middle segment,
wherein, in the preformed configuration, the second length of the middle segment is at least 40% shorter than the first length of the central lumen in the radially constrained configuration, and
wherein each of the proximal and distal flange structures has a diameter greater than twice a diameter of the middle segment and greater than the second length of the middle segment.

US Pat. No. 10,390,832

DEVICES AND METHODS FOR EFFECTUATING PERCUTANEOUS GLENN AND FONTAN PROCEDURES

The United States of Amer...

1. A reinforced endograft shunt prosthesis, comprising:a distal flange configured to help seat the prosthesis when it is pulled proximally;
a distal segment extending proximally from the distal flange that has sufficient stiffness to maintain a puncture in an open condition that is formed through a first vessel wall through which the distal segment passes;
a compliant middle segment extending proximally from the distal segment, the compliant middle segment being more compliant than the distal segment, and including a plurality of undulating strut rings attached to at least one of an inner tubular fabric and an outer tubular fabric, the combined structure providing flexibility and compliance to allow for full patency while flexed, the segment being further configured to accommodate up to a 90 degree bend;
a proximal segment having a plurality of adjacent undulating strut rings that are connected to each other, the proximal segment being sufficiently stiff to seat within and urge against a second vessel wall; and
an undulating proximal end including a tether that is threaded through the openings to cause the proximal end of the prosthesis to collapse radially inwardly when tension is applied to the tether.

US Pat. No. 10,390,829

STAPLES COMPRISING A COVER

Ethicon LLC, Guaynabo, P...

1. A staple cartridge assembly, comprising:a cartridge body, comprising:
a deck; and
a plurality of staple cavities defined in said deck; and
a plurality of staples stored in said staple cavities, wherein each said staple comprises:
a metal frame comprised of a magnesium alloy, wherein said metal frame comprises a base and a leg extending from said base, and wherein said leg comprises a tissue penetrating tip; and
a magnesium nitride coating on said tissue penetrating tip.

US Pat. No. 10,390,827

MULTI-LAYER POROUS FILM MATERIAL

Covidien LP, Mansfield, ...

1. A surgical stapling apparatus comprising:a handle assembly;
a tubular body portion extending from the handle assembly;
a staple cartridge assembly extending from the tubular body portion;
an anvil assembly coupled to the staple cartridge assembly and movable relative thereto between open and closed positions; and
a surgical buttress releasably attached to the staple cartridge assembly or the anvil assembly, the surgical buttress including first, second, and third porous film layers successively stacked on each other and interconnected at a plurality of attachment points that define a plurality of pockets between the first and second porous film layers and the second and third porous film layers, wherein the plurality of attachment points between the first and second porous film layers of the surgical buttress are different from the plurality of attachment points between the second and third porous film layers of the surgical buttress such that the plurality of attachment points form at least one of the plurality of pockets between the first and second porous film layers that is different in size from at least one of the plurality of pockets between the second and third porous film layers.

US Pat. No. 10,390,822

SURGICAL FASTENERS AND METHODS AND DEVICES FOR DEPLOYING A SURGICAL FASTENER

DEPUY SYNTHES PRODUCTS, I...

1. A surgical system, comprising:a surgical fastener having a first leg, a second leg, and an intermediate portion extending therebetween, at least a portion of the surgical fastener being formed from a shape memory material, the surgical fastener being movable between a substantially linear configuration and a bent configuration, and the first and second legs being configured to be advanced through tissue and into bone with the intermediate portion being positioned outside the bone, the surgical fastener being biased to the bent configuration when no external force is applied thereto; and
a cannula having an inner lumen extending therethrough and having an opening formed through a sidewall thereof at a distal end of the elongate cannula, the opening extending proximally from a distal-most end of the cannula and terminating distal to a proximal end of the cannula;
wherein the surgical fastener is configured to be disposed within the inner lumen of the cannula in the substantially linear configuration and to move from the substantially linear configuration within the inner lumen to the bent configuration with the first leg advanced out of the inner lumen through the distal-most end of the cannula, the intermediate portion extending through the opening, and the second leg being disposed within the inner lumen.

US Pat. No. 10,390,821

SOFT TISSUE FIXATION USING A LOOPED SUTURE CONSTRUCT

1. A method of suturing soft tissue comprising:passing a loop of suture through soft tissue, the loop of suture exiting the tissue through a first location on a tissue surface;
passing a first free end of the suture through the soft tissue adjacent the loop of suture, the first free end of the suture exiting the tissue through a second location on the tissue surface, wherein the suture is slidably connected to a suture attaching mechanism of an anchoring structure such that the attaching mechanism is between the loop of suture and the first free end of the suture;
passing a second free end of the suture through the soft tissue adjacent the loop of suture, the second free end of suture exiting the tissue through a third location on the tissue surface, wherein the suture attaching mechanism is between the loop of suture and the second free end of the suture;
passing the first free end of the suture through the loop of suture;
applying tension to the first free end of the suture such that the soft tissue is pulled into contact with a desired structure and the loop of suture remains open and positioned on the first tissue surface, wherein the desired structure is bone, the anchoring structure or a second anchoring structure; and
securing the first free end of the suture to maintain the applied tension.

US Pat. No. 10,390,820

MEDICAL INSTRUMENT FOR MICROINVASIVE SURGICAL INTERVENTIONS

1. A system for a minimally invasive medical procedure in a body cavity bounded by a body cavity wall with an access opening, the system comprising:two medical instruments, each including a rigid shaft having:
a proximal end that is mechanically connectable or connected with an operational device of the respective medical instrument;
a distal end that is connectable or connected with a tool of the respective medical instrument; and
a longitudinal axis extending between the proximal end and the distal end, at least a portion of the rigid shaft being curved along the longitudinal axis;
wherein no plane exists from which respective center points of all cross-sections of the rigid shaft defined in respective planes perpendicular to the longitudinal axis are at a respective distance less than one-third of a diameter of the rigid shaft;
wherein no plane exists in which all respective center points of all cross-sections of the rigid shaft defined in respective planes perpendicular to the longitudinal axis are located;
wherein the proximal end and the distal end are oriented parallel to one another or form an angle of at most 20 degrees to one another; and
wherein the rigid shaft comprises a proximal portion, a center portion, and a distal portion and wherein the distal portion and the proximal portion lie in a plane from which the center portion deviates;
wherein respective helical portions of the rigid shafts are configured to be wound around one another in a double helix manner to permit simultaneous use of the rigid shafts through the access opening of the body cavity wall.

US Pat. No. 10,390,819

AUTOMATIC SUTURING HOOK APPARATUS HAVING INCISION FUNCTION

INJE UNIVERSITY INDUSTRY-...

1. An automatic suturing hook apparatus having an incision function, comprising:a main body having a movement hole formed on one side surface thereof and having a first protrusion hole formed on a front end thereof;
a needle part which is provided inside the main body and protrudes from the first protrusion hole;
a slide body which slidably moves through the movement hole from one side surface of the main body to the front end or rear end of the main body and comes into close contact with the front end of the main body;
a slide part which is provided inside the main body and slidably moves the needle part provided inside the main body to the outside of the main body; and
a first trigger which is provided at the bottom of the rear end of the main body and operates the slide part which is provided inside the main body,
wherein a second protrusion hole is formed in the main body to be spaced apart from the first protrusion hole, and
the automatic suturing hook apparatus further comprises:
a cutter which is provided at a lower portion of the needle part inside the main body and protrudes toward the second protrusion hole; and
a second trigger which is disposed adjacent to the first trigger and slidably moves the cutter protruding toward the second protrusion hole.

US Pat. No. 10,390,818

FERRULE FOR USE WITH A MINIMALLY INVASIVE SURGICAL SUTURING DEVICE

LSI Solutions, Inc., Vic...

1. A ferrule for use with a surgical suturing device, comprising:a suture interface;
a needle tip receptacle;
three indentations protruding into the needle tip receptacle; and
three slits, each of the slits substantially centered between a different pair of indentations from the three indentations, wherein the slits do not contact the three indentations, and wherein each of the slits is longer and thinner than any one of the three indentations.

US Pat. No. 10,390,816

APPARATUSES AND METHODS FOR FIXATION OF ANKLE SYNDESMOSIS OR ACROMIOCLAVICULAR JOINT DISLOCATIONS OF THE SHOULDER

ARTHREX, INC., Naples, F...

1. An apparatus for performing ankle syndesmosis repairs, comprising:a first button including an oblong shape that is adapted for insertion through a bone hole in a first configuration and for engaging a tibial cortex in a second configuration;
a second button that includes a shape that is different from the oblong shape of the first button, wherein the first button and the second button are metallic buttons;
a first suture connecting the first button and the second button and including at least four strands extending between the first button and the second button, wherein a first free end and a second free end of the first suture are tensionable to shorten a length of the first suture between the first button and the second button and thereby move the first button and the second button closer together, wherein the first suture is double looped through each of a first aperture and a second aperture of the first button;
a pull-through device configured for pulling the first button through the bone hole; and
a second suture connecting the pull-through device to the first button.

US Pat. No. 10,390,815

TISSUE REPAIR DEVICE

1. A tissue repair device comprising:a handle;
a cannula coupled to the handle, the cannula having a central axis;
a first anchor disposed entirely within the cannula for deployment along a first deployment path and a second anchor offset with respect to the first anchor and configured to deploy along a second deployment path distinct from the first deployment path, the first anchor coupled to the second anchor via a knotted flexible member; and
a pusher assembly including an actuator configured to reciprocate between a proximal end of the cannula wherein the first anchor and the second anchor are successively engaged, and a more distal position within the cannula, wherein the first anchor and the second anchor are successively expelled from the cannula after traversing their respective deployment paths for delivery of the knotted flexible member to secure the tissue.

US Pat. No. 10,390,814

MENISCAL REPAIR DEVICES, SYSTEMS, AND METHODS

MEDOS INTERNATIONAL SARL,...

1. A surgical system, comprising:a cannula configured to have a surgical device advanced therethrough, the cannula including concentric inner and outer tubes that have distal ends fixed together, the outer tube being configured to longitudinally translate, along a longitudinal axis of the outer tube, relative to the inner tube and thereby cause a distal portion of the cannula to articulate; and
an actuator threadably engaged with the outer tube and configured to be rotated to cause the longitudinal translation of the outer tube relative to the inner tube;
wherein the inner tube has a first plurality of slits formed in a distal portion thereof that are configured to facilitate the articulation, and the outer tube has a second plurality of slits formed in a distal portion thereof that are configured to facilitate the articulation; and
wherein the first plurality of slits are formed on a first side of the cannula, and the second plurality of slits are formed on a second, opposite side of the cannula.

US Pat. No. 10,390,813

SYSTEMS, IMPLANTS, TOOLS, AND METHODS FOR TREATMENTS OF PELVIC CONDITIONS

Boston Scientific Scimed,...

1. A retractor assembly for retracting pelvic tissue, the assembly comprising:an introducer including:
an open proximal end having a first cross-sectional dimension;
a closed distal end having a second cross-sectional dimension and including a distal tip;
an inner opening extending along a length of the introducer through the open proximal end to the closed distal end of the introducer; and
an outer shell defining the inner opening, the outer shell including a first section and a second section, the first section being removably attached to the second section along one seam that continuously extends longitudinally from the open proximal end on one lateral side of the introducer, transversely across the distal tip, to the open proximal end of the other lateral side of the introducer; and
a retractor including:
an open proximal end having a first cross-sectional dimension;
a distal end having a second cross-sectional dimension; and
a body defining an inner opening and having a first outer periphery that is smaller than the inner opening of the introducer along at least a portion of a length of the retractor, such that at least a portion of the length of the retractor is insertable into the inner opening of the introducer at the open proximal end of the introducer,
wherein the first cross-sectional dimension of the proximal end of the introducer is substantially larger than the second cross-sectional dimension of the distal end of the introducer and the first cross-sectional dimension of the proximal end of the retractor is substantially larger than the second cross-sectional dimension of the distal end of the retractor,
wherein the retractor is expandable such that the body attains a second outer periphery that is larger than the inner opening of the introducer, the retractor is expandable such that the proximal end of the retractor has a third cross-sectional dimension and the distal end of the retractor has a fourth cross-sectional dimension, the third cross-sectional dimension of the proximal end of the retractor being substantially larger than the fourth cross-sectional dimension of the distal end of the retractor.

US Pat. No. 10,390,812

TWO-STAGE SPINAL ACCESS ASSEMBLY

MH BROOK, INC., Hopkinto...

1. A surgical retractor system, comprising:a first retractor having a proximal end and a distal end, wherein the first retractor comprises a tube that can be passed through a tissue site to provide access through a first working channel forming a passage through an interior of the first retractor; and
a second retractor having a proximal end and a distal end and comprising a pair of blades proximate the distal end of the second retractor, each blade in the pair of blades being concave inward with respect to a second working channel proximal end axis of the blade;
wherein the second retractor has a first configuration in which the second retractor is dimensioned to be insertable through the first working channel of the first retractor, and wherein the proximal end of the second retractor is positionable in the vicinity of the first retractor distal end, and wherein a distance between the pair of blades can be expanded to form a second working channel through the second retractor while the second retractor proximal end is positioned through the first working channel such that the blades of the second retractor extend beyond the first retractor distal end and both the first retractor and second retractor simultaneously retract tissues and allow surgical access through the first and second working channels.

US Pat. No. 10,390,811

DEVICE FOR PROVIDING AN ACCESS OPENING IN A BODY, IN PARTICULAR FOR A SPINAL OPERATION

1. A device for providing an access opening in a human body, comprising:a tubular device body that extends along a longitudinal axis, said tubular device body, having a distal end configured to be positioned inside a human body and a proximal end configured to be positioned outside of the human body;
a guideway element configured to be positioned in an operating position in the region of the proximal end of the tubular device body, said guideway element can be brought into said operating position by pivoting around a swivel axis with respect to the tubular device body, said guideway element having a guideway region providing a ring shaped path of motion around the longitudinal axis of the tubular device body when said guideway element is in the operating position;
a movable optics-carrier movably carried on the guideway element so as to be movable along the ring shaped path of motion provided by the guideway region for adjusting a position of the optics carrier with respect to the guideway region when the guideway element is in the operating position; and
wherein the guideway element has a swivel/lock region for pivotable mounting and locking of the guideway element in the operating position on a swivel bracket element that extends away from the tubular device body.

US Pat. No. 10,390,810

MULTI-LUMEN TAMPER TUBE

Essential Medical, Inc., ...

1. A closure device for sealing a percutaneous puncture in a wall of a body passageway, the closure device comprising:a plug configured to engage a surface of the puncture;
a toggle configured to engage an internal surface of the body passageway;
an elongate filament coupled to the toggle and the plug configured to associate the plug with the toggle;
a locking member disposed along the elongate filament and configured to slide along the elongated filament to engage the plug; and
a tamper disposed on the elongate filament at a location that is proximal to the locking member, the tamper having a proximal end, a distal end spaced from the proximal end, a first lumen that extends from the proximal end to the distal end, and a second lumen that extends from the proximal end to the distal end, wherein the first lumen and the second lumens are sized such that the locking member is prevented from being pushed inside the first and second lumens when the tamper slides along the elongated filament to tamper the locking member against the plug.

US Pat. No. 10,390,809

INSERTION TOOL FOR A MEDICAL CLOSURE DEVICE

TERUMO EUROPE N.V., Leuv...

1. An insertion tool for a medical device for closure of an opening in a wall of a bodily organ, the medical device comprising a first member and a second member connected by a filament, the insertion tool comprising:a first housing;
a tamping tube having a proximal end that is located in the first housing, and a distal end that is located outside the first housing, the tamping tube being configured to allow the filament to be threaded therethrough;
a tamping trigger that is attached to the first housing, the tamping trigger being configured to releasably hold the tamping tube, and being configured to be actuated by a user;
a spring located in the first housing;
wherein the insertion tool is configured such that, (i) prior to actuation of the tamping trigger by the user, the tamping tube is held by the tamping trigger, and the spring is energized and applies an application force to the tamping tube, and (ii) upon actuation of the tamping trigger by the user, the tamping trigger releases the tamping tube and the spring advances the tamping tube in a distal direction relative to the first housing, such that the distal end of the tamping tube can bring together the first and second members of the medical device.

US Pat. No. 10,390,798

COMPUTER-AIDED TRACKING AND MOTION ANALYSIS WITH ULTRASOUND FOR MEASURING JOINT KINEMATICS

Oxford University Innovat...

1. A motion analysis system, comprising:at least one ultrasonic imaging device;
at least one motion sensing device;
at least one computing device in data communication with the at least one ultrasonic imaging device and the at least one motion sensing device; and
a tracking application executable in the at least one computing device, the tracking application comprising logic that:
accesses video generated from the at least one ultrasonic imaging device and the at least one motion sensing camera;
tracks a target patch embodied in a plurality of frames of the ultrasound video by:
compressing a plurality of patches of individual ones of the frames of the ultrasound video into a plurality of vectors;
generating a space partitioning data structure for each of the frames of the ultrasound video;
identifying an image intensity feature for each frame utilizing a corresponding one of the space partitioning data structures generated for each frame of the ultrasound video; and
determines a plurality of optimized tracking locations for a sequence of the ultrasound video using the image intensity feature identified for each frame.

US Pat. No. 10,390,795

IMAGE PROCESSING APPARATUS AND METHOD

SAMSUNG MEDISON CO., LTD....

1. An ultrasound image processing apparatus comprising:a display configured to display a first rendered image corresponding to a volume data;
an input device configured to receive an edit request including a selection of an editing area in an image plane of the first rendered image, and a recover request, and to transmit the received information to an image processor; and
the image processor configured:
to determine, from the first rendered image, a first surface of a target object;
in response to the receipt of the edit request including the selection of the editing area, to determine a depth value which indicates a depth of a portion of the first surface of the target object, from the image plane, in the editing area,
to obtain a second rendered image which indicates at least a second surface of the target object in the editing area based on the depth value, wherein the portion of the first surface of the target object, the second surface, and the editing area are aligned with each other in a depth direction,
to control the display to display the second rendered image indicating an entire portion of the volume data that is below the second surface and is within the editing area, and
to control the display to display a third rendered image based on receiving the recover request,
wherein in the editing area, the third rendered image indicates a third surface at a depth deeper than the portion of the first surface indicated in the first rendered image and shallower than the second surface indicated in the second rendered image.

US Pat. No. 10,390,788

MULTIPLE-DIMENSION IMAGING SENSOR WITH OPERATION BASED ON DETECTION OF PLACEMENT IN MOUTH

DENTAL IMAGING TECHNOLOGI...

1. A method for determining that an intra-oral imaging sensor is positioned in a mouth of a patient, the intra-oral imaging sensor including a temperature sensor, the method comprising:receiving, by an electronic processor, an output from the temperature sensor indicative of a sensed temperature; and
determining that the intra-oral imaging sensor is positioned in the mouth of the patient based at least in part on the output from the temperature sensor.