US Pat. No. 10,188,846

TWO-WAY RETRACTABLE MEDICAL TUBING REEL

1. A two-way retractable medical tubing reel system comprising:a housing comprising an interior, an exterior, a top, a bottom, a proximal aperture and a distal aperture;
a generally cylindrical reel rotatably mounted in the housing interior and having a reel wall comprising an outer surface having an outer surface circumference, an inner surface having an inner surface circumference, a first wall aperture and a second wall aperture, the reel wall separating a reel exterior from a reel interior;
a spindle located in the housing interior;
a generally cylindrical spring container located in the reel interior, the spring container comprising a spring attached to the spindle;
a track attached to the reel wall and comprising a first end, a U-shaped segment, an internal segment, a second end, and a track length extending from the first end to the second end, wherein the internal segment extends from the first wall aperture to the second wall aperture and is located between the spring container and the inner surface of the reel wall;
a sterile generally hollow tube located in the track and extending along the track length, the sterile generally hollow tube also wrapped around the outer surface circumference, the track comprising a proximal end configured to connect to a patient, a distal end configured to connect to an intravenous (IV) fluid bag, and a tube length extending from the proximal end to the distal end, the generally hollow tube passing through the proximal and distal apertures;
the generally hollow tube having an extended position wherein a segment of the generally hollow tube is fully enclosed in the housing;
the generally hollow tube having a retracted position wherein a longer segment of the tube is fully enclosed in the housing as compared to the extended position and wherein the generally hollow tube wraps around the outer surface circumference a greater number of times as compared to the extended position;
wherein the spring is configured to bias the generally hollow tube in the retracted position;
wherein pulling on the proximal end and the distal end of the generally hollow tube in the retracted position is configured to cause the generally cylindrical reel to rotate relative to the housing and move the generally hollow tube to the extended position.

US Pat. No. 10,188,845

HEMOSTASIS VALVE ASSEMBLY

St. Jude Medical, Cardiol...

1. A hemostasis valve assembly, comprising:a housing; and
a valve member positioned within the housing, the valve member comprising:
opposed first and second primary surfaces and a valve thickness defined between the first and second primary surfaces;
an opening formed in the first primary surface;
first and second slits arranged intersecting each other in an axial direction along a central axis, wherein the central axis extends from the first primary surface to the second primary surface, the first and second slits extending through a portion of the valve thickness, the first slit accessible within the opening and extending from the opening through the valve thickness to a depth within the valve located a distance from the second primary surface, and the second slit accessible from the second primary surface and extending from the second primary surface through the valve thickness to a depth within the valve located a distance from a bottom surface of the opening; and
a recess positioned between the opening and the first and second slits, wherein the opening has a first diameter and the recess has a second diameter, the first diameter being smaller than the second diameter.

US Pat. No. 10,188,836

FOLDING INSERTER FOR DRUG DELIVERY INFUSION SET

Becton, Dickinson and Com...

1. An infusion set, comprising:a base; and
an inserter pivotally connected to said base, said inserter including:
a catheter movable from a first catheter position to a second catheter position;
an introducer needle located within said catheter and movable between a first introducer needle position and a second introducer needle position; and
an activation button movable between first and second button positions, wherein when said activation button is moved from said first button position to said second button position, said catheter is moved from said first toward said second catheter position, said introducer needle is moved from said first toward said second introducer needle position to facilitate insertion of said catheter, and said introducer needle is thereafter moved back toward said first introducer needle position to store said introducer needle within said inserter with a free end of said catheter remaining disposed externally of said inserter and said base;
wherein in the first button position, the inserter is not configured to fold substantially entirely within said base in the first inserter position, and in the second button position, the inserter is configured to fold substantially entirely within said base in the second inserter position.

US Pat. No. 10,188,821

OXYGEN CONCENTRATION DEVICE

Teijin Pharma Limited, T...

1. An oxygen concentration device which generates oxygen-enriched gas, comprising: adsorbent cylinders packed with an adsorbent which preferentially adsorbs nitrogen rather than oxygen; a compressor which supplies compressed air to the adsorbent cylinders; a flow path switching valve for switching between a flow path between the compressor and the adsorbent cylinders and a flow path between the adsorbent cylinders and an exhaust pipe for discharging desorbed gas to outside of the system in order to repeat at a fixed timing an adsorption step in which compressed air is supplied to the adsorption cylinders and nitrogen in the compressed air is adsorbed to generate unadsorbed oxygen, a desorption step in which the adsorption cylinders are purged under reduced pressure to desorb the nitrogen and regenerate the adsorbent, and a pressure equalization step in which an adsorbent cylinder after completion of the adsorption step and an adsorption cylinder after completion of the desorption step are connected to each other to equalize pressure of the two cylinders; and a pressure equalization valve provided on a pressure equalization path which connects between the adsorbent cylinders, wherein a pressure control member having a difference in pressure loss due to the direction of gas flow is provided at at least one end side of the pressure equalization valve so that pressure loss of gas which flows through the pressure equalization path in one direction becomes nearly equal to that of the gas which flows therethrough in the opposite direction.

US Pat. No. 10,188,810

INHALER

VECTURA DELIVERY DEVICES ...

1. An inhaler comprising a housing defining a chamber to receive a strip having a plurality of blisters each containing a dose of medicament for inhalation by a user, a cap, an actuating member which has a gear element having teeth, and a blister strip indexing wheel rotatably mounted in the chamber to sequentially move each blister into a blister opening position, wherein the cap and the actuating member are combined into a single component and wherein the blister strip indexing wheel and the cap are coupled by a drive gear that cooperates with the gear element to effect rotation of the blister strip indexing wheel in response to rotation of the cap, said drive gear and gear element being disposed on an outside of the housing remote from the chamber.

US Pat. No. 10,188,776

NEGATIVE PRESSURE DEVICE

1. Apparatus for providing negative pressure at a wound site, the apparatus comprising:a negative pressure reservoir configured to contain a first zone of negative pressure;
a chamber configured to contain a second zone of negative pressure, the chamber configured to communicate negative pressure to a wound dressing; and
a valve element arranged to selectively provide a fluid communication path between the reservoir and the chamber, the valve element comprising an exterior surface exposed to an ambient atmospheric pressure, an inner surface fixed relative to the exterior surface such that movement of the exterior surface causes movement of the inner surface, a first portion of the inner surface configured to be exposed to the first zone of negative pressure, and a second portion of the inner surface configured to be exposed to the second zone of negative pressure, the valve element further arranged to selectively block the fluid communication path when the exterior surface moves to a first position, the valve element further arranged to selectively open the fluid communication path when the exterior surface moves to a second position, wherein the exterior surface moves from the first position to the second position as a result of the ambient atmospheric pressure acting on the exterior surface and a negative pressure acting on the inner surface.

US Pat. No. 10,188,771

METHOD OF TREATING PERIPHERAL ARTERY DISEASES IN LOWER LIMBS

TERUMO KABUSHIKI KAISHA, ...

1. A method of treating peripheral artery diseases in lower limbs, comprisinginserting a medical device into a peripheral blood vessel, the medical device comprising a polyamide expandable member possessing a polyamide surface on which a drug coating layer is disposed, the drug coating layer being applied to the polyamide surface of the polyamide expandable member by reverse rotation in which the expandable member is rotated in an opposite direction of dispensing the drug coating layer and in which the drug coating layer is dispensed by a dispenser in contact with the polyamide surface of the expandable member, the drug coating layer having a crystalline morphological form including a plurality of crystal particles of a water-insoluble drug regularly arranged and uniformly sized on the polyamide surface of the polyamide expandable member, each of the crystal particles being independently formed on the polyamide surface of the polyamide expandable member,
expanding the polyamide expandable member,
pressing the drug coating layer to a blood vessel wall of the peripheral blood vessel such that at least part of the plurality of crystals is transferred to the blood vessel wall, and
deflating the polyamide expandable member such that a pharmacokinetics profile is presented in which a drug concentration in the blood vessels is kept for the inhibition of smooth muscle cell proliferation in a first drug-concentration period of time, and for the non-inhibition of endothelial cell growth in a later second drug-concentration period of time, the drug-concentration in the first drug-concentration period of time being higher than the drug-concentration in the second drug-concentration period of time.

US Pat. No. 10,188,769

BIOCOMPATIBLE SUBSTRATE FOR FACILITATING INTERCONNECTIONS BETWEEN STEM CELLS AND TARGET TISSUES AND METHODS FOR IMPLANTING SAME

UNIVERSITY OF SOUTHERN CA...

1. A method for treating retinal degenerative disease comprising:providing a substrate seeded with cells suitable for implantation into an ocular tissue of a patient, wherein the substrate comprises:
a parylene layer with an apical surface for growth of a population of cells, wherein the parylene layer has a thickness between 0.1 microns and 6 microns;
a plurality of supporting protrusions each extending 1 micron or greater from a basal surface of the parylene layer to a terminating free end of the supporting protrusion;
implanting the substrate into the ocular tissue of the patient; and
positioning the substrate so that the substrate is parallel with an outer nuclear layer of photoreceptors in an eye of the patient.

US Pat. No. 10,188,768

MINIATURE SCENT GENERATING DEVICE

NATIONAL TSING HUA UNIVER...

9. A miniature non-atomizer type scent generating device, comprising:a scented component including a housing, a chamber located in the housing, a ventilation opening penetrating the housing to communicate with the chamber, and a vibration unit disposed in the chamber;
a plurality of solid-state scented particles or microcapsules encapsulating essences disposed in the chamber and having a scent; and
a driving unit comprising a control circuit and connected to the vibration unit;
wherein the vibration unit is controlled by the driving unit to produce a back and forth vibration which directly pushes gas inside the chamber and accordingly induces a unidirectional airflow of perturbation in the chamber;
wherein the unidirectional airflow of perturbation accompanies the solid-state scented particles or microcapsules encapsulating essences flowing through the ventilation opening and out of the chamber to enhance the dispersing of the scent;
wherein the vibration unit comprises:
a piezoelectric film layer;
a first electrode layer, connected to the piezoelectric film; and
a second electrode layer, connected to the piezoelectric film;
wherein the piezoelectric film layer is sandwiched between the first electrode layer and the second electrode layer, and the first electrode layer and the second electrode layer are respectively electrically connected to the driving unit to generate a varying electric field at the piezoelectric film to cause the piezoelectric film layer to produce the vibration.

US Pat. No. 10,188,759

CONJUGATES FOR IMAGING

Endocyte, Inc., West Laf...

1. A conjugate, or a pharmaceutically acceptable salt thereof, of the formula

US Pat. No. 10,188,756

IMAGING HISTONE DEACETYLASES WITH A RADIOTRACER USING POSITRON EMISSION TOMOGRAPHY

The General Hospital Corp...

1. A compound of formula (I):
wherein R1 is a moiety including a substituted or unsubstituted adamantyl group and a contrast agent,
wherein R2 represents hydrogen, or substituted or unsubstituted alkyl, or substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, or substituted or unsubstituted heterocyclic, and
wherein n is an integer selected from 0 or 1, and
wherein the compound has a brain to plasma ratio greater than 1, and wherein at least one atom in R1 is replaced with a positron emitter selected from the group consisting of 11C, 13N, 15O, 18F, 34mCl, 38K, 45Ti, 51Mn, 52mMn, 52Fe, 55Co, 60Cu, 61Cu, 62Cu, 64Cu, 66Ga, 68Ga, 71As, 72As, 74As, 75Br, 76Br, 82Rb, 86Y, 89Zr, 90Nb, 94mTc, 110mIn, 118Sb, 120I, 121I, 122I, and 124I.

US Pat. No. 10,188,753

METHOD FOR INTEGRATING NANOPARTICLES AS PART OF A HYDROGEL MATRIX

Verily Life Sciences LLC,...

1. A method for forming a nanosensor-containing crosslinked polymer, the method comprising:forming a mixture comprising a nanosensor, a crosslinkable polymer precursor, and a surfactant, wherein
the nanosensor comprises a hydrophobic nanoparticle having a detectable label configured to interact with a specific analyte present in a transdermal environment, and
the surfactant comprises one or more chemically-reactive groups capable of forming a covalent bond with the crosslinkable polymer precursor; and
subjecting the mixture to conditions suitable to initiate crosslinking of the crosslinkable polymer precursor, such that the nanosensor is disposed in the crosslinked polymer, and the crosslinked polymer is covalently bound to the surfactant.

US Pat. No. 10,188,728

COMPOSITIONS AND METHODS FOR TREATMENT OF CANCER

1. A composition for treating cancer comprising targeted liposomes comprising a chemotherapy agent and a sensitizer for the chemotherapy agent, and non-targeted liposomes comprising an anti-angiogenic agent, wherein:said targeted liposomes are immunoliposomes that bind to Her-2/neu;
said chemotherapy agent is doxorubicin, carboplatin, cisplatin, cyclophosphamide, docetaxel, erlotinib, etoposide, fluorouracil, gemcitabine, imatinib mesylate, irinotecan, methotrexate, paclitaxel, sorafinib, sunitinib, topotecan, vincristine or vinblastine;
said sensitizer is verapamil; and
said anti-angiogenic agent is bevacizumab.

US Pat. No. 10,188,652

COMPOSITIONS AND METHODS FOR TREATING INSOMNIA

1. A method of treating insomnia, comprising administrating orally a dosage form comprising a therapeutically effective amount of compound A, wherein said therapeutically effective amount is a single daily dose ranging from about 2.5 mg to about 10 mg, wherein said single daily dose achieves a mean Cmax of from about 3.0 ng/ml to about 7.2 ng/ml for each 1 mg of compound A after administration to human subjects, and said compound A is (1R,2S)-2-(((2,4-dimethylpyrimidin-5-yl)oxy)methyl)-2-(3-fluorophenyl)-N-(5-fluoropyridin-2-yl) cyclopropanecarboxamide represented by the following formula:

US Pat. No. 10,188,641

COMPOSITIONS AND METHODS FOR TREATMENT

SARCODE BIOSCIENCE INC., ...

1. A method of treating dry eye disease in a subject in need thereof comprising administering to the subject an effective amount of a lymphocyte function associated antigen-1 (LFA-1) antagonist or a pharmaceutically acceptable salt or ester thereof, wherein the LFA-1 antagonist is

US Pat. No. 10,188,634

3-(3H-IMIDAZO[4,5-C]PYRIDIN-2-YL)-1 H-PYRAZOLO[4,3-B]PYRIDINES AND THERAPEUTIC USES THEREOF

Samumed, LLC, San Diego,...

1. A compound, or a pharmaceutically acceptable salt thereof, of Formula I:
wherein:
R1 and R2 are independently selected from the group consisting of H and halide;
R3 is selected from the group consisting of heteroaryl optionally substituted with 1-4 R6 and -heterocyclyl optionally substituted with 1-10 R7;
R5 is selected from the group consisting of heteroaryl optionally substituted with 1-4 R8, -heterocyclyl optionally substituted with 1-10 R9, and -aryl optionally substituted with 1-5 R10;
each R6 is independently selected from the group consisting of halide, —(C1-6 alkyl), —(C2-6 alkenyl), —(C2-6 alkynyl), —(C1-4 alkylene)pheterocyclyl optionally substituted with 1-10 R11, —(C2-4 alkenylene)pheterocyclyl optionally substituted with 1-10 R11, —(C2-4 alkynylene)pheterocyclyl optionally substituted with 1-10 R11, —(C1-4 alkylene)pcarbocyclyl optionally substituted with 1-12 R12, —(C2-4 alkenylene)pcarbocyclyl optionally substituted with 1-12 R12, —(C2-4 alkynylene)pcarbocyclyl optionally substituted with 1-12 R12, —(C1-4 alkylene)paryl optionally substituted with 1-5 R13, —(C2-4 alkenylene)paryl optionally substituted with 1-5 R13, —(C2-4 alkynylene)paryl optionally substituted with 1-5 R13, —NHC(?O)R14, —NR15R16, —(C1-6 alkylene)NR17R18, —(C2-6 alkenylene)NR17R18, —(C2-6 alkynylene)NR17R18, and —(C1-4 alkylene)pOR24;
each R7 is independently selected from the group consisting of —(C1-4 alkyl), —(C2-4 alkenyl), —(C2-4 alkynyl), halide, —CF3, and —CN;
each R8 is independently selected from the group consisting of —(C1-6 alkyl), —(C2-6 alkenyl), —(C2-6 alkynyl), halide, —CF3, —OCH3, —CN, and —C(?O)R19;
each R9 is independently selected from the group consisting of —(C1-6 alkyl), —(C2-6 alkenyl), —(C2-6 alkynyl), halide, —CF3, —CN, and —OCH3;
each R10 is independently selected from the group consisting of —(C1-6 alkyl), —(C2-6 alkenyl), —(C2-6 alkynyl), halide, —CF3, —CN, —(C1-6 alkylene)pNHSO2R19, —(C2-6 alkenylene)pNHSO2R19, —(C2-6 alkynylene)pNHSO2R19, —NR15(C1-6 alkylene)NR15R16, —NR15(C2-6 alkenylene)NR15R16, —NR15(C2-6 alkynylene)NR15R16, —(C1-6 alkylene)pNR15R16, —(C2-6 alkenylene)pNR15R16, —(C2-6 alkynylene)pNR15R16, and —OR27;
each R11 is independently selected from the group consisting of amino, —(C1-4 alkyl), —(C2-4 alkenyl), —(C2-4 alkynyl), halide, —CF3, and —CN;
each R12 is independently selected from the group consisting of —(C1-4 alkyl), —(C2-4 alkenyl), —(C2-4 alkynyl), halide, —CF3, and —CN;
each R13 is independently selected from the group consisting of —(C1-4 alkyl), —(C2-4 alkenyl), —(C2-4 alkynyl), halide, —CF3, and —CN;
each R14 is independently selected from the group consisting of —(C1-9 alkyl), —(C1-4 haloalkyl), —(C2-9 alkenyl), —(C2-9 alkynyl), -heteroaryl optionally substituted with 1-4 R20, -aryl optionally substituted with 1-5 R21, —CH2aryl optionally substituted with 1-5 R21, -carbocyclyl optionally substituted with 1-12 R22, —CH2carbocyclyl optionally substituted with 1-12 R22, —(C1-4 alkylene)pNR25R26, (C2-4 alkenylene)pNR25R26, —(C2-4 alkynylene)pNR25R26, -heterocyclyl optionally substituted with 1-10 R23, and —CH2heterocyclyl optionally substituted with 1-10 R23;
each R15 is independently selected from the group consisting of H, —(C1-6 alkyl), —(C2-6 alkenyl), and —(C2-6 alkynyl);
each R16 is independently selected from the group consisting of H, —(C1-6 alkyl), —(C2-6 alkenyl), —(C2-6 alkynyl), —CH2aryl optionally substituted with 1-5 R21, and —CH2carbocyclyl optionally substituted with 1-12 R22;
each R17 is independently selected from the group consisting of H, —(C1-6 alkyl), —(C2-6 alkenyl), and —(C2-6 alkynyl);
each R18 is independently selected from the group consisting of H, —(C1-6 alkyl), —(C2-6 alkenyl), —(C2-6 alkynyl), —CH2aryl optionally substituted with 1-5 R21, and —CH2carbocyclyl optionally substituted with 1-12 R22;
each R19 is independently selected from the group consisting of —(C1-6 alkyl), —(C2-6 alkenyl), and —(C2-6 alkynyl);
each R20 is independently selected from the group consisting of —(C1-4 alkyl), —(C2-4 alkenyl), —(C2-4 alkynyl), halide, —CF3, and —CN;
each R21 is independently selected from the group consisting of —(C1-4 alkyl), —(C2-4 alkenyl), —(C2-4 alkynyl), halide, —CF3, and —CN;
each R22 is independently selected from the group consisting of —(C1-4 alkyl), —(C2-4 alkenyl), —(C2-4 alkynyl), halide, —CF3, and —CN;
each R23 is independently selected from the group consisting of —(C1-4 alkyl), —(C2-4 alkenyl), —(C2-4 alkynyl), halide, —CF3, and —CN;
R24 is selected from the group consisting of H, —(C1-6 alkyl), —(C2-6 alkenyl), —(C2-6 alkynyl), —(C1-4 alkylene)pheterocyclyl optionally substituted with 1-10 R23, —(C2-4 alkenylene)pheterocyclyl optionally substituted with 1-10 R23, —(C2-4 alkynylene)pheterocyclyl optionally substituted with 1-10 R23, —(C1-4 alkylene)pcarbocyclyl optionally substituted with 1-12 R22, —(C2-4 alkenylene)pcarbocyclyl optionally substituted with 1-12 R22, —(C2-4 alkynylene)pcarbocyclyl optionally substituted with 1-12 R22, —(C1-4 alkylene)paryl optionally substituted with 1-5 R21, —(C2-4 alkenylene)paryl optionally substituted with 1-5 R21, —(C2-4 alkynylene)paryl optionally substituted with 1-5 R21, —(C1-6 alkylene)pNR25R26, (C2-4 alkenylene)pNR25R26, and (C2-4 alkynylene)pNR25R26;
each R25 is independently selected from the group consisting of H, —(C1-6 alkyl), —(C2-6 alkenyl), and —(C2-6 alkynyl);
each R26 is independently selected from the group consisting of H, —(C1-6 alkyl), —(C2-6 alkenyl), and —(C2-6 alkynyl);
R27 is selected from the group consisting of H, —(C1-6 alkyl), —(C2-6 alkenyl), —(C2-6 alkynyl), —(C1-4 alkylene)pheterocyclyl optionally substituted with 1-10 R23, —(C2-4 alkenylene)pheterocyclyl optionally substituted with 1-10 R23, —(C2-4 alkynylene)pheterocyclyl optionally substituted with 1-10 R23, —(C1-6 alkylene)pNR25R26, —(C2-6 alkenylene)pNR25R26, and —(C2-6 alkynylene)pNR25R26; and
each p is independently an integer of 0 or 1.

US Pat. No. 10,188,629

PRODRUG OF GREEN TEA EPIGALLOCATECHIN-3-GALLATE (PRO-EGCG) FOR USE IN THE TREATMENT OF ENDOMETRIOSIS

1. A method of treating endometriosis or a related indication comprising administering to a subject in need thereof, via enteral or intraperitoneal administration, or an injection into the vagina or uterine cavity, an effective amount of Pro-EGCG having the formula:

US Pat. No. 10,188,606

EXPANSILE CROSSLINKED POLYMERSOME FOR PH-SENSITIVE DELIVERY OF ANTICANCER DRUGS

Mayo Foundation for Medic...

1. A polymer of Formula (I):
wherein:
each R is independently C1-6 alkyl; and
n is an integer between 1 and 50.

US Pat. No. 10,188,597

HAIR COLOR STAIN REMOVER AND METHOD OF USE

1. A hair color stain remover formula, comprising by volume:a) about 67.9999% Witch Hazel Extract;
b) about 20.0% Glycerin;
c) about 8.8% Distilled Water;
d) about 3.0% Sodium Cocoyl Glycinate;
e) about 0.1% Potassium Sorbate;
f) about 0.1% Sodium Benzoate; and
g) about 0.0001% Green Tea Extract.

US Pat. No. 10,188,592

2-PYRONES

Merck Patent GmbH, Darms...

1. A cosmetic or pharmaceutical composition comprising at least one compound of the formula (I)
where
R1 stands for a straight-chain or branched C1- to C20-alkyl group,
R2 stands for
H or
straight-chain or branched C1- to C20-alkyl group,
R4 stands for
H,
straight-chain or branched C1- to C20-alkyl group or
straight-chain or branched C2- to C20-alkenyl group having one or more double bonds,
R3 stands for a radical selected from
H,
straight-chain or branched C2- to C20-alkyl group,
straight-chain or branched C2- to C20-alkenyl group having one or more double bonds, where the alkenyl group may also be substituted by one or more saturated or unsaturated C3- to C12-cycloalkyl groups,
straight-chain or branched C2- to C20-alkynyl group having one or more triple bonds,
saturated or partially unsaturated non-aromatic C3- to C12-cycloalkyl group,
where the rings may in each case also be bridged by —(CH2)n— groups where n=1 to 3,
an acyl radical of the formula —C(?O)—R6,
R6 stands for
straight-chain or branched C1- to C20-alkyl group,
a radical of the formula (II)

in which X stands for straight-chain or branched C1- to C6-alkylene or straight-chain or branched C2- to C6-alkenylene and the radicals R5 are selected, independently of one another, from H, OH, straight-chain or branched C1- to C6-alkyl or straight-chain or branched O—(C1- to C6-alkyl),
at least one vehicle which is suitable for a topical application, and
a further anti-ageing or anti-cellulite active compound;
with the proviso that
R4 is a straight-chain or branched C2- to C20-alkenyl group having one or more double bonds or
R3 is a straight-chain or branched C2- to C20-alkenyl group having one or more double bonds, where the alkenyl group may also be substituted by one or more saturated or unsaturated C3- to C12-cycloalkyl groups,
straight-chain or branched C2- to C20-alkynyl group having one or more triple bonds,
saturated or partially unsaturated non-aromatic C3- to C12-cycloalkyl group, where the rings may in each case also be bridged by —(CH2)n— groups where n=1 to 3, or an acyl radical of the formula —C(?O)—R6.

US Pat. No. 10,188,586

GASTRIC SYSTEMS, APPARATUS, AND METHODS FOR USE WITH ENTERAL FEEDING

Avent, Inc., Alpharetta,...

1. A gastric pressure relief system comprising:a feeding container connected to an administration tubing;
a relief tubing;
a delivery tube in fluid communication with the administration tubing and the relief tubing;
a multi-way connector having a first arm, a second arm, and a third arm, wherein
the first arm is connected to the relief tubing,
the second arm is connected to the delivery tube, and
the third arm is connected to the administration tubing;
a collection reservoir in fluid communication with the relief tubing, wherein
the collection reservoir includes a vent configured to allow gas to pass through in both directions and configured to restrict the flow of liquid through the vent, wherein the vent comprises a top membrane and a side membrane,
the collection reservoir is configured to collect reflux fluids from a patient's stomach via the relief tubing, and
the collection reservoir comprises volumetric indicia configured to represent a volume of reflux fluids received from the patient's stomach; and
a flow regulator adapted to regulate flow within the relief tubing.

US Pat. No. 10,188,585

DEVICE FOR THE SUBLINGUAL ADMINISTRATION OF A MEDICATION FORMED FROM DISSOLVING A TABLET IN A LIQUID

1. A device for the sublingual administration of a liquid medication formed from dissolving a tablet in a dissolving liquid comprising:an upper portion connected to a lower portion;
the upper portion comprising:
a bottom surface having at least one post and opposite the bottom surface, a cylindrical cavity having a base wall;
a hollow needle having a piercing tip extending upward from the base wall; the cylindrical cavity sized to receive and align an external source containing a dissolving liquid, said hollow needle capable of piercing one end of the external source by the piercing tip;
the lower portion comprising:
a recess sized to accept a tablet of medication, the recess having a base wall having an exit pathway to a discharge located at the side of the lower portion opposite the recess for sublingual administration; and,
when the upper portion and lower portion are connected, the interior space within the recess bordered by the base wall of the upper portion form a chamber having an interior volume and the at least one post sufficiently extends into the chamber to fracture a tablet of medication positioned within the chamber and the needle is a conduit for a dissolving liquid to enter the chamber.

US Pat. No. 10,188,584

MEDICINAL XIDING VIAL AND DISPENSING APPARATUS AND INJECTION APPARATUS THEREOF

1. An assembly of a reversely pressed medicinal vial and a reversely pressed injection apparatus, comprising the reversely pressed medicinal vial and the reversely pressed injection apparatus,wherein the reversely pressed medicinal vial includes a vial body whose inner wall is a straight cylinder, a first piston is disposed on a position close to a vial opening of the vial body, a blind hole is disposed at a center of an outer bottom surface of the first piston, and the vial opening is provided with an outer edge protruding radially outwardly from the vial opening and a seal cap is fixed on the outer edge to prevent the first piston from falling off;
wherein the reversely pressed injection apparatus includes an injection tube, a fixed push rod and an inner needle which longitudinally penetrates the fixed push rod are provided at a bottom center of the injection tube inside the injection tube, a needle head of the inner needle sticks out of the fixed push rod, an outer needle is provided at an outlet port of the injection tube, a tail part of the outer needle is communicated with a tail part of the inner needle, an inner wall of the injection tube is clearance-fitting with the outer edge of the vial opening, and a free end of the fixed push rod is fitted and connected with the blind hole at the center of the outer bottom surface of the first piston,
wherein an annular sealing gasket that is integrated therewith is disposed at the outer bottom surface of the first piston and positioned between the vial opening and the seal cap; and
wherein the free end of the fixed push rod is sleeved with an annular blade, and when the reversely pressed medicinal vial is assembled with the reversely pressed injection apparatus, the annular blade cuts and separates the first piston from the annular sealing gasket, the inner needle impales into the first piston, the first piston is pushed into the vial body in a direction away from the vial opening by the fixed push rod, and the annular sealing gasket is disposed at the vial opening.

US Pat. No. 10,188,582

OUT OF PHASE CHEST COMPRESSION AND VENTILATION

ZOLL Medical Corporation,...

1. A system for providing emergency care to a patient, the system comprising:a backboard arranged to support the patient;
a chest compressor attached to the backboard and positioned to engage the patient at the chest, the chest compressor configured to provide multiple chest compression cycles to the patient, wherein the multiple chest compression cycles are configured to provide a compression of the sternum to a compressed sternal position followed by a hold of the sternum in the compressed sternal position followed by a release of the sternum from the compressed sternal position;
a cuirass attached to the backboard and positioned to engage the patient at the abdomen, the cuirass configured to generate negative pressure to pull outward on the abdomen and to provide multiple abdominal compression cycles to the patient wherein the multiple abdominal compression cycles are configured to provide a compression of the abdomen to a compressed abdominal position followed by a hold of the abdomen in the compressed abdominal position followed by a release of the abdomen from the compressed abdominal position; and
a defibrillator comprising one or more processors configured to:
control the chest compressor to perform the multiple chest compression cycles and the cuirass to perform the multiple abdominal compression cycles according to a programmed sequence such that the compression of the sternum to the compressed sternal position occurs during the hold of the abdomen in the compressed abdominal position and after the compression of the abdomen to the compressed abdominal position and such that the release of the sternum from the compressed sternal position occurs over a pre-determined time interval, and
control the cuirass to generate the negative pressure to pull outward on the abdomen prior to the compression of the abdomen to the compressed abdominal position.

US Pat. No. 10,188,579

METHOD FOR CONTROLLING A WALKING ASSISTANT APPARATUS

National Chiao Tung Unive...

1. A method for controlling a walking assistant apparatus, the walking assistant apparatus including a processor, a motion unit, a support unit that is disposed on the motion unit and that includes a handle component operable by a user, a first scanning device disposed on the support unit, and a torque sensor disposed on the handle component, the method comprising the steps of:a) scanning, by the first scanning device, the user so as to generate scanning information associated with gait of the user;
b) detecting, by the torque sensor, a detected torque applied thereto about a vertical axis;
c) estimating, by the processor, a moving speed of the user based on the scanning information;
d) calculating, by the processor, a compliant motion speed based at least on the moving speed of the user, and a compliant rotational speed based on the detected torque detected in step b); and
e) controlling, by the processor, the motion unit to move at the compliant motion speed and to turn at the compliant rotational speed so as to bring the walking assistant apparatus to move at the compliant motion speed and to turn at the compliant rotational speed;
wherein step a) includes scanning the user so as to generate the scanning information that includes a first entry of distance information scanned at a first time instance and a second entry of distance information scanned at a second time instance after the first time instance;
wherein step c) includes the sub-steps of
calculating a first distance between the first scanning device and the user at the first time instance based on the first entry of distance information,
calculating a second distance between the first scanning device and the user at the second time instance based on the second entry of distance information, and
calculating the moving speed of the user based on the first distance, the second distance and a difference between the first time instance and the second time instance; and
step d) includes calculating the compliant motion speed based on the detected torque and the second distance.

US Pat. No. 10,188,578

POWERED HANDLE BAR APPARATUS FOR STAIRCASE, RAMP OR LEVEL WALK AREA WALKING ASSISTANCE FOR CHALLENGED INDIVIDUALS

1. A powered handle bar apparatus for walking assistance comprises:a trolley support bar;
a handle;
a handle operating system;
a control box;
a drive assembly;
an access control reader;
at least one accessory;
a power source;
the trolley support bar being mounted on to a solid surface area;
the control box being terminally connected to the trolley support bar;
the handle being operatively coupled to the trolley support bar by the drive assembly;
the access control reader, the at least one accessory, and the power source being integrated into the control box;
the drive assembly, the access control reader, and the at least one accessory being electrically connected to the power source through the handle operating system;
the at least one accessory comprises a landline phone system;
the landline phone system comprises a phone interface and a phone module;
the phone interface being adjacently connected to the handle;
the phone module being mounted within the control box; and
the phone interface being communicably coupled to the phone module.

US Pat. No. 10,188,574

PATELLA GRIPPER AND DEVICE FOR MOVING A PATELLA COMPRISING SUCH A PATELLA GRIPPER

1. A device for moving a patella with a patella gripper for a patella, comprising:the patella gripper comprising:
a retaining element having a lower face and
a contact finger apparatus, which is arranged on the lower face of the retaining element and is configured to grip the patella,
wherein the contact finger apparatus comprises at least two contact finger units, which are arranged on opposite sides of the retaining element,
wherein the contact finger apparatus is rotatably arranged on the retaining element so that the contact finger apparatus can be rotated on an axis that is aligned perpendicularly to the longitudinal axis of the retaining element and perpendicularly to the transverse axis of the retaining element,
and wherein the contact finger apparatus is adapted to move the patella in one of the cranial-caudal direction and in the medial-lateral direction by the at least two contact finger units;
a leg holding device configured to receive a leg of a patient;
one or more drive units for moving the at least two contact finger units; and
a control unit for controlling the one or more drive units,
wherein the at least two contact finger units are moved linearly with respect to at least one of the retaining element and the leg holding device by the one or more drive units.

US Pat. No. 10,188,565

TRANSPORT CHAIRS

The UAB Research Foundati...

1. A wheelchair comprising:a seat assembly comprising a seat having a front edge and a rear edge;
a footrest assembly comprising an upright member having an upper end and a lower end, and a foot plate extending from said upright member near the lower end thereof;
said seat assembly and said footrest assembly pivotally coupled to one another near said front edge and said upper end, defining a single pivot axis therebetween,
said seat assembly and footrest configured to maintain a uniform spatial relationship while pivoting rotationally about said single pivot axis from a first seated position in which said footplate is elevated above a floor to a second seated position at which said foot plate contacts the floor, whereupon said seat assembly is configured to decouple from said footrest assembly and continue pivoting to an inclined position.

US Pat. No. 10,188,564

ABSORBENT ARTICLE COMPRISING FLUID HANDLING ZONES

1. An absorbent article comprising:a. a topsheet comprising a first nonwoven;
b. a backsheet;
c. an absorbent core disposed between the topsheet and the backsheet;
d. a second nonwoven disposed between the first nonwoven and the absorbent core;
e. a first fluid handling zone comprising a first portion of the topsheet and comprising a first Transverse Fluid Travel Distance, wherein the first portion comprises a first macro feature having an area greater than 2 mm2, and a first micro feature having an area less than that of the first macro feature, wherein the first macro feature and the first micro feature comprise apertures extending out of plane;
f. a second fluid handling zone comprising a second portion of the topsheet and comprising a second Transverse Fluid Travel Distance, wherein the second portion comprises a second macro feature that is different than the first macro feature, and wherein the second macro feature has an area of less than 5 mm2;
g. wherein the first Transverse Fluid Travel Distance is greater than the second Transverse Fluid Travel Distance; and
h. wherein the second portion further comprises micro features.

US Pat. No. 10,188,563

ABSORBENT ARTICLES WITH PULPLESS RIFFLED CORE

DSG Technology Holdings L...

1. A disposable absorbent article disposed in a generally flat, open condition, the disposable absorbent article comprising:a central body including an absorbent core, a front longitudinal edge, and a rear longitudinal edge opposite said front longitudinal edge, wherein said front and rear edges of said central body define, at least partially, front and rear waist portions respectively and said central body is characterized by a longitudinal centerline extending across said front and rear edges; and
wherein the absorbent core comprises:
a riffled substrate comprising a plurality of peaks and a plurality of troughs;
a flat substrate coupled to the riffled substrate; and
superabsorbent polymer disposed between the riffled substrate and the flat substrate;
wherein the footprint of the riffled substrate is substantially the same as the footprint of the flat substrate; and
wherein the surface area of the riffled substrate is greater than the surface area of the flat substrate; and
wherein the peaks and troughs of the riffled substrate are spaced apart from the flat substrate.

US Pat. No. 10,188,560

ABSORBENT ARTICLE HAVING FINGER TABS AND METHODS OF MANUFACTURING SAME

KIMBERLY-CLARK WORLDWIDE,...

1. A method of manufacturing an absorbent article, the method comprising:feeding a first web of material in a machine direction;
feeding a second web of material in the machine direction, the second web being spaced from the first web by a gap;
attaching an absorbent assembly to the first web and the second web such that the absorbent assembly spans the gap between the first and second webs;
forming a partial cut line through the second web, wherein the second web includes opposing side edges extending in the machine direction, the partial cut line spaced from the side edges of the second web;
folding the first web into face-to-face relationship with the second web after forming the partial cut line; and
cutting the first and second webs after folding the first web into face-to-face relationship with the second web to separate the absorbent article from the first and second webs, the partial cut line defining at least one finger tab on the absorbent article.

US Pat. No. 10,188,559

DISPOSABLE DIAPER WITH BUTTOCKS PART STRETCHING UNIT

UNICHARM CORPORATION, Eh...

1. A disposable diaper, comprising:a front waistline region;
a back waistline region; and
a crotch region positioned between the front waistline region and the back waistline region;
a product longitudinal direction oriented from the front waistline region to the back waistline region;
a product widthwise direction orthogonal to the product longitudinal direction:
an absorber running across the crotch region and extending to at least one of the front waistline region and the back waistline region;
a pair of side flaps extending across the front waistline region, the crotch region, and the back waistline region, said pair of side flaps being disposed on opposite sides of the absorber in the product widthwise direction; and
a pair of fastening tapes each extending, in the product widthwise direction, in the back waistline region outward of the pair of side flaps, respectively, said pair of fastening tapes being releasably attachable to the front waistline region;
wherein
each side flap of the pair of side flaps has:
a lateral edge including an leg opening unit concave toward a center of the absorber in the product widthwise direction, said leg opening unit having a center in the product longitudinal direction;
a leg stretching unit disposed inward of the leg opening unit in the product widthwise direction and stretchable in the product longitudinal direction; and
a buttocks part stretching unit running across the crotch region and the back waistline region, and stretchable in the product longitudinal direction;
the leg opening unit in said each side flap has:
a backside leg opening unit positioned backward of the center of the leg opening unit in the product longitudinal direction; and
a foreside leg opening unit positioned forward of the center of the leg opening unit in the product longitudinal direction,
wherein an area between the backside leg opening unit and a straight line, which passes through the center of the absorber in the product widthwise direction and which is parallel to the product longitudinal direction, is larger than an area between the foreside leg opening unit and the straight line, and
in said each side flap,
said buttocks part stretching unit is disposed outward of the leg stretching unit in the product widthwise direction,
a front end of the buttocks part stretching unit is positioned backward of the center of the leg opening unit in the product longitudinal direction and reaches the lateral edge of the side flap, and
a plurality of convex units convex away from the absorber in the product widthwise direction is formed only in the backside leg opening unit and outward of the front end of the buttocks part stretching unit in the product widthwise direction.

US Pat. No. 10,188,558

MALE URINARY INCONTINENCE DEVICE

1. A method of treating urinary incontinence in a human male having a penis having a penis head, the method comprising the steps of:a) providing a wrap configured to absorb urine and having:
i) a distal region configured to absorb urine and comprised of a plurality of layers, the distal region further comprising a front surface, a rear surface opposite the front surface, a distal region left side, a distal region right side, a distal region length extending from the distal region left side to the distal region right side, a distal region proximal end, a distal region distal end, a distal region width extending from the distal region proximal end to the distal region distal end and generally perpendicular to the distal region length;
ii) a lengthwise foldline located at the proximal end of the distal region and extending generally parallel to the distal region length;
iii) a proximal region configured to absorb urine and comprised of a plurality of layers, the proximal region further comprising a proximal region distal end extending from the distal region at the lengthwise foldline, the proximal region further comprising a proximal region proximal end, a proximal region width extending from the proximal region proximal end to the proximal region distal end, a proximal region left side, a proximal region right side, a length extending from the proximal region left side to the proximal region right side;
iv) a left widthwise foldline extending through the proximal and distal regions generally along the proximal and distal region widths; and
v) a right widthwise foldline located to the right of the left widthwise foldline and extending through the proximal and distal regions generally along the proximal and distal region widths,
wherein the front surface of the proximal region left side comprises a left side fastener configured to removably attach to the distal region rear surface, and wherein the front surface of the proximal region right side comprises a right side fastener configured to removably attach to the proximal region rear surface;
b) placing the head of the penis of the male on the proximal region front surface;
c) before or after step b), folding the distal region along the lengthwise foldline so that the distal region front surface faces the proximal region front surface; and
d) folding the left side of the proximal region and the left side of the distal region together along the left widthwise foldline toward the head of the user's penis, attaching the left side fastener to the distal region rear surface, and then folding the right side of the proximal region and the right side of the distal region together along the right widthwise foldline toward the head of the penis, and attaching the right side fastener to the proximal region rear surface,wherein after step d), the right sides of the proximal region and distal region are located in front of the left sides of the proximal region and the distal region and further wherein after steps b) and c), the head of the penis is located between the front surface of the proximal region and the front surface of the distal region.

US Pat. No. 10,188,557

APPARATUS AND PROCESS FOR TRANSFERRING SUBSTRATE MATERIAL AND PARTICULATE MATERIAL

1. An apparatus for making a structure that comprises a combination of a particulate material and a substrate material, including:a) a first moving endless surface with a direction of movement (MD) and with one or more of reservoirs, said first moving endless surface and reservoirs thereof being for transferring particulate material to:
b) a second moving endless surface with a direction of movement (MD) carrying a substrate material for receiving said particulate material from said first moving endless surface in a receiving zone and for transferring said combination of said particulate material and said substrate material in a transferring zone, said second moving endless surface being in said receiving zone adjacent a first vacuum chamber and being in gas communication therewith, and said second moving endless surface being in said transferring zone adjacent a second vacuum chamber, and being in gas communication therewith, said receiving zone and said transferring zone being adjacent (in MD) one another,
c) an adhesive application unit for applying adhesive to said combination of said substrate and said particulate material, said adhesive application unit positioned downstream of said first moving endless surface opposite said second moving endless surface and said second vacuum chamber in said transferring zone;
wherein the ratio of the said negative vacuum pressure in said first vacuum chamber to the negative vacuum pressure in said second vacuum chamber is at least 4:3; and
d) an anvil roll downstream of said transferring zone for receiving said combination of said particulate material and said substrate material and combining said combination with a further substrate material.

US Pat. No. 10,188,556

WOUND BARRIER PAD

1. A sacral wound barrier pad device for treating a wound on a patient, comprising:a first sacral pad having a first internal wall that defines a first interior opening;
a second sacral pad having a second internal wall that defines a second interior opening, wherein said first sacral pad is adhered to said second sacral pad, said sacral pads being aligned such that said first interior opening corresponds generally to said second interior opening so as to permit placement of said sacral wound barrier pad device on a patient such that no sacral pad surface is positioned directly over a wound; and
a resilient, semi-rigid insert situated between said first sacral pad and said second sacral pad, wherein said insert may be at least partially folded whereby when applied to said patient said insert generates an expansion force upon said first sacral pad, said second sacral pad, and skin of said patient to prevent a shearing force from being applied to said wound.

US Pat. No. 10,188,552

SURGICAL SYSTEM PROVIDING HANDS-FREE CONTROL OF A SURGICAL TOOL

The Johns Hopkins Univers...

1. A surgical system providing hands-free control of at least one surgical tool, comprising:a robot having a tool connector;
a smart tool attached to said tool connector of said robot; and
a feedback control system configured to communicate with said smart tool to provide feedback control of said robot,
wherein said smart tool comprises:
a tool comprising a tool shaft having a distal end and a proximal end;
a strain sensor arranged at a first position along said tool shaft;
at least one of a second strain sensor or a torque-force sensor arranged at a second position along said tool shaft, said second position being more towards said proximal end of said tool shaft than said first position; and
a signal processor configured to communicate with said strain sensor and said at least one of said second strain sensor or said torque-force sensor to receive detection signals therefrom,
wherein said signal processor is configured to process said detection signals to determine a magnitude and position of a lateral component of a force applied to said tool shaft when said position of said applied force is between said first and second positions,
wherein said lateral component of said force is a component of said force that lies in a plane that is orthogonal to said tool shaft at said position at which said force is applied, and
wherein said feedback system controls said robot to move in response to at least said magnitude and position of said lateral component of said force applied to said tool shaft when said position of said applied force is between said first and second positions so as to cancel said force applied to said tool shaft to thereby provide hands-free control of said at least one surgical tool.

US Pat. No. 10,188,541

IMMOBILIZING SPLINTS

1. An immobilizing splint for an antecubital intravenous injection site, the splint comprising:a sleeve of a flexible foam material configured to be selectively and removably closed around an elbow of an arm of a patient;
a preformed opening in the sleeve configured to allow visual access to an antecubital fossa of the elbow, wherein the preformed opening has a presized perimeter that is closed and continuous;
at least two straps configured to close the sleeve around the elbow, wherein each strap of the at least two straps includes a hook-and-loop fastener; and
two stiffening members configured to maintain the elbow in an at least substantially extended position when the sleeve is closed around the elbow to prevent a kink in a portion of an intravenous supply tube that underlies the splint when the sleeve is closed around the elbow, wherein the stiffening members are positioned in the sleeve on opposite sides of the preformed opening such that, when the sleeve is closed around the elbow in a position that allows visual access to the antecubital fossa through the preformed opening, the stiffening members are positioned on an anterior side of the arm.

US Pat. No. 10,188,535

MEDICAL DEVICES HAVING ENHANCED PERFORMANCE

Boston Scientific Scimed,...

1. A medical device, comprising:an expandable framework of oriented polymer fibers, wherein a binding polymer portion of one polymer fiber and a fibrous polymer reinforcement portion of another polymer fiber form a reinforced composite region, wherein the fibrous polymer reinforcement portion comprises, relative to a longitudinal axis of the framework, one of the following fractions, any two of the following fractions, or all three of the following fractions:
a first fraction oriented at a first angle relative to the longitudinal axis;
a second fraction oriented at a second angle relative to the longitudinal axis; and
a third fraction oriented at a third angle relative to the longitudinal axis.

US Pat. No. 10,188,534

STENT HAVING REDUCED PASSAGE OF EMBOLI AND STENT DELIVERY SYSTEM

Covidien LP, Mansfield, ...

1. An expandable tubular stent for implantation in a body lumen comprising:a structural portion extending along an axis being radially expandable thereabout and having a first expanded percentage open area, the structure portion including a plurality of struts; and
a barrier portion affixed to the structural portion and having a second expanded percentage open area, the barrier portion including a plurality of pores extending therethrough, the barrier portion being at least partially made of metal;
the stent having a composite expanded percentage open area within a range of 65% to 95%, wherein the composite expanded percentage open area is calculated by finding a difference between an area of the pores of the expanded barrier portion and an area of said pores occluded by the struts of the expanded structural portion, and dividing said difference by surface area of the expanded stent.

US Pat. No. 10,188,530

PROVISIONAL TIBIAL PROSTHESIS SYSTEM

Zimmer, Inc., Warsaw, IN...

1. A tibial prosthesis system for implantation on a resected surface of a proximal tibia, the tibial prosthesis system comprising:a bearing component having a superior surface and an inferior surface;
a base component having a superior surface and an inferior surface, wherein the base component having a protrusion extending from the superior surface and configured to mate with a recess in the bearing component, the protrusion having a first feature configured to couple with a second feature of the bearing component when the protrusion is inserted into the recess to prevent significant relative movement between the bearing component and the base component in a medial/lateral direction and an anterior/posterior direction, and wherein the first feature and the second feature are configured to allow the bearing component to be movable relative to the base component in a proximal/distal direction; and
a shim component insertable between the inferior surface of the bearing component and the superior surface of the base component, wherein upon insertion the shim component is configured to engage both the bearing component and the base component to restrain the bearing component from significant relative movement in the proximal/distal direction relative to the base component, and wherein the shim component is configured to be disposed between the inferior surface of the bearing component and the superior surface of the base component.

US Pat. No. 10,188,529

DEVICES AND METHODS FOR INTER-VERTEBRAL ORTHOPEDIC DEVICE PLACEMENT

1. An instrument assembly for delivery of an orthopedic implant to a target location within a spinal segment of a subject, comprising:an orthopedic implant;
an implant insertion member comprising a first elongated curvilinear body and an internal bore, at least a portion of said internal bore is extended from a proximal opening to a distal opening along a curvilinear trajectory, said internal bore configured for advancement of said orthopedic implant from said proximal opening to said distal opening; and
a fixation member comprising a first segment configured to attach onto a proximal segment of said implant insertion member, and a second segment configured to attach onto a first surface of said spinal segment, said fixation member configured to limit movement of said implant insertion member relative to said target location in at least one plane;
wherein said orthopedic implant is sized to be advanced from said proximal opening to said distal opening of said internal bore and onto said target location.

US Pat. No. 10,188,526

SPINAL IMPLANT SYSTEM AND METHOD

Warsaw Orthopedic, Inc., ...

15. A surgical instrument comprising:a tubular shaft;
a first rotatable arm connected with the shaft;
a second rotatable arm connected with the shaft; and
a drive rod translatable relative to the shaft and including at least one ramp that is translatable relative to the shaft to engage and rotate the arms relative to the shaft between a capture orientation and a release orientation with an interbody implant,
the rod being engageable with the interbody implant to move at least a portion of the interbody implant between a contracted configuration and an expanded configuration.

US Pat. No. 10,188,518

ANNULOPLASTY RING WITH VARIABLE CROSS-SECTION

Edwards Lifesciences Corp...

15. An elongated annuloplasty ring, comprising:an elongated ring body comprising an inner single piece metallic structural support surrounded by a suture permeable interface, the ring body surrounding a central open area through which passes a flow axis and being discontinuous so as to define two free ends at a break in continuity around a periphery of the ring body, wherein the ring body has a relaxed configuration shaped to mimic a three-dimensional path along a non-planar native valve annulus,
wherein the structural support has a radial cross-section that gradually changes around a length of the structural support and has a C-shaped part in a mid-portion, and wherein the two free ends of the structural support are rectangular in radial cross-section and are more flexible in bending about the flow axis than the C-shaped part of the cross-section, and wherein the two free ends of the ring body are axially offset from each other.

US Pat. No. 10,188,512

REVERSIBLE CAVITARY TENSION MEMBRANE

1. An apparatus for supporting and uniformly covering at least in one plane a cavity structure without obstructing the flow of fluid through the cavity structure, the apparatus comprising:an expandable membrane configured to transition between an expanded state and a shrunken state, wherein the membrane is comprised of a first layer and a second layer, the edges of which are joined together to create a closed chamber between the first layer and the second layer, the membrane comprising:
an internal face and an external face opposite the internal face;
a tension mechanism disposed between the internal face and the external face and configured to exert force on the first layer and the second layer to place the expandable membrane in the expanded state;
and at least one orifice disposed between the internal face and the external face, wherein the external face is in fluid communication through the orifice with an empty space defined by the internal face of the membrane when the membrane is in the expanded state.

US Pat. No. 10,188,511

BIOPROSTHETIC TISSUE WITH REDUCED CALCIFICATION

Edwards Lifesciences Corp...

1. A packaged bioprosthetic device comprising:an at least partially cross-linked pericardial tissue comprising functional groups that have been blocked, removed or altered by reacting the functional groups with capping agents, wherein the functional groups are one or both of aldehyde groups and carboxylic acid groups; and
a packaging storing the at least partially cross-linked biological tissue without a liquid preservative solution.

US Pat. No. 10,188,508

BIOENGINEERED VOCAL FOLD MUCOSA FOR FUNCTIONAL VOICE RESTORATION

Wisconsin Alumni Research...

1. An engineered vocal fold mucosa comprising:(a) an engineered non-vascularized lamina propria comprising a scaffold comprising polymerized collagen populated by a plurality of human vocal fold fibroblasts (VFFs); and
(b) an engineered stratified squamous epithelium in contact with the engineered non-vascularized lamina propria of (a), the stratified squamous epithelium comprising a plurality of human vocal fold epithelial cells (VFEs);
wherein the engineered vocal fold mucosa, when implanted into a larynx, exhibits vibratory function and acoustic output of a native human vocal fold mucosa.

US Pat. No. 10,188,487

DENTAL IMPLANT SUPERSTRUCTURE SUPPORT

1. A superstructure support (20) for disposition as part of a prosthetic tooth replacement (1) between an implantation body (10) and a superstructure consisting of an artificial crown (120) or a composite of a cement body (100) and the crown (120), the superstructure support (20) comprising:a screw insertion opening (61) including three zones extending through from a top surface to a bottom surface of the superstructure support (20);
an upper zone (67) having a cylindrical bore with a centerline (69) proximate to the top surface;
a lower zone (62) having a cylindrical bore with a centerline (63) proximate to the bottom surface;
an intermediate transition zone (64) positioned between the lower and upper zones having an internal conical area (65) coaxial with the centerline (63);
an outer area (51) adjacent the implantation body (10) having an implantation neck (52) including outer cone (53) above which an implant plate (31) is arranged;
a crown-supporting area (21) provided with an engagement structure (41) and an implantation post (23) which includes a screw seating bore (62);
a smooth microstructure surface (71) with an average arithmetic roughness value of 1.5 to 3.0 ?m provided with webs or grooves (74) at least partially extending around the superstructure support (20); and
spaced edges acting as bacteria barriers formed between a plurality of adjacent conical areas arranged on top of one another provided at the bottom side (32) of the implantation plate (31) on top of the implantation neck (52),
wherein an angle in the range of 155 to 178 angular degrees is formed between the centerline (69) of the upper zone and the centerline (63) of the lower zone.

US Pat. No. 10,188,484

SYSTEM OF COMPONENTS OR IMPLEMENTS FOR EASILY AND PRECISELY INSTALLING A DENTAL IMPLANT, AND A METHOD OF INSTALLING THE DENTAL IMPLANT

1. A system for implementing the installation of a winged dental implant within a blind bore implantation site defined within a patient's jaw, comprising:a rotary cutter assembly comprising a rotary cutting disk mounted upon a support post; and
a rotary cutter guide to be disposed within the blind bore implantation site defined within the patient's jaw, wherein said rotary cutter guide comprises a base portion and an upstanding body portion, a first vertically extending through-slot defined within said upstanding body portion of said rotary cutter guide such that said first vertically extending through-slot extends through said rotary cutter guide along a first plane from a first wall portion of said upstanding body portion to a second oppositely disposed wall portion of said upstanding body portion, and a second vertically extending through-slot defined within said rotary cutter guide such that said second vertically extending through-slot extends through said rotary cutter guide along a second plane which is disposed orthogonally with respect to said first plane such that said second slot extends from a third wall portion of said upstanding body portion to a fourth oppositely disposed wall portion of said upstanding body portion,
wherein said support post of said rotary cutter assembly extends through said first vertically extending through-slot defined within said upstanding body portion of said rotary cutter guider while oppositely disposed stub portions of said support post extend outwardly from said oppositely disposed first and second wall portions of said first vertically extending through-slot defined within said upstanding body portion of said rotary cutter guide so as to stably support said rotary cutter assembly within said rotary cutter guide, and opposite sides of said rotary cutting disk project outwardly from said oppositely disposed third and fourth wall portions of said second vertically extending through-slot defined within said upstanding body portion of said rotary cutter guide so as to be capable of cutting oppositely disposed slots within the patient's jaw for accommodating oppositely disposed wing members of the winged dental implant.

US Pat. No. 10,188,483

GASTRO-INTESTINAL SCOPE STERILIZATION, DISINFECTION AND STORAGE DEVICE AND METHODS OF MAKING AND USING SAME

16. A method of constructing gastro-intestinal (GI) scope disinfection and sterilization device, comprising the steps of:providing a gastro-intestinal (GI) scope with an insertion tube having a first end and a second end, a control section such that the second end of the insertion tube is operatively connected to the control section, a universal cord having a first end and a second end such that the first end of the universal cord is operatively connected to the control section and the second end of the insertion tube is operatively connected to a suction connector, and
providing an ultraviolet (UV) light assembly, wherein the UV light assembly is further comprised of;
a power source,
a first electrical extension operatively connected to the power source,
a UV light box operatively connected to the first electrical extension, and
first and second UV light sources operatively connected to the UV light box, wherein each of the first and second UV light sources includes a first end and a second end, wherein the first UV light source is located within an interior of the insertion tube and the second UV light source is located within an interior of the universal cord in order to disinfect and sterilize an interior of the gastro-intestinal (GI) scope and wherein each of the first and second UV light sources is further comprised of a UV light having a tube and a plurality of UV lights located on the tube.

US Pat. No. 10,188,480

SYSTEMS AND METHODS FOR PERFORMING SPINE SURGERY

NuVasive, Inc., San Dieg...

1. A system for global alignment of a spine during spinal surgery, the system comprising an imaging device, a spatial tracking system, a bending device, and, a control unit configured to:receive a planned target value of one or more spinal parameters;
based on the planned target value of the one or more spinal parameters, determine one or more ranges corresponding to a desired correction in at least one of (i) a sagittal alignment and (ii) a coronal alignment of the spine;
capture, via the imaging device and the spatial tracking system, one or more intraoperative fluoroscopy images;
measure an intraoperative value of the one or more spinal parameters according to the one or more captured intraoperative fluoroscopy images;
compare the intraoperative value of the one or more spinal parameters with the planned target value of the spinal parameters;
based on the comparison, determine that the intraoperative value of the one or more spinal parameters is within the one or more ranges and measure a location of one or more screws; and
calculate an instruction to bend a rod, via the bending device, to the location of the one or more screws.

US Pat. No. 10,188,479

CARRYING BAG

1. A negative pressure wound therapy kit comprising:a negative pressure wound therapy system comprising:
a housing enclosing a source of negative pressure configured to provide negative pressure wound therapy to a wound, the housing comprising a user interface positioned on an exterior of the housing; and
a canister configured to be attached to the housing and to be in fluidic communication with the source of negative pressure configured to provide negative pressure wound therapy to a wound negative pressure, the canister including a tubing configured to be fluidically connected to the wound; and
a carrying case comprising:
a pouch sized to enclose the housing and the canister of the negative pressure wound therapy system, the pouch having a window configured to permit viewing of the user interface, the pouch further comprising an opening sized to allow the housing and the canister to be placed into the pouch by being passed through the opening;
a fastener adapted to close at least a first portion of the opening while leaving a second portion of the opening open, the second portion of the opening being sized so that the tubing can pass through the second portion of the opening while the housing and the canister cannot pass through the second portion of the opening;
a pocket disposed on the carrying case and outside of the pouch, the pocket sized to enclose at least a portion of the tubing passed through the second portion of the opening, wherein the at least the portion of tubing comprises excess tubing in use; and
first and second flaps configured to conceal the housing and the canister of the negative pressure wound therapy system, the first flap configured to cover at least the window in a first position and to permit viewing of the window in a second position.

US Pat. No. 10,188,476

MEDICAL GOWN HAVING AN INTEGRAL PROTECTIVE SLEEVE FOR MEDICAL EQUIPMENT

1. A protective medical gown comprising:a gown body adapted to be worn by a medical professional, the gown body having a front panel section, the gown body oriented by an exterior surface and an interior surface when worn;
an orifice centrally located in a central region of a front portion of the gown body; and
a tubular protective sleeve joined to the gown body at an attachment end circumscribing the centrally located orifice, the tubular protective sleeve extending freely and outward from the gown body, the tubular protective sleeve having a shape and size to receive a distal portion of a medical device;
an interior pocket separate segment from the tubular protective sleeve assembled to the interior surface of the gown body, the interior pocket comprising a sheet of material joined to the interior surface of the gown body along each of a first edge of the interior pocket and a second edge of the interior pocket, the interior pocket located to support a proximal portion of the medical device, having a first end proximate the centrally located orifice and a second end proximate a neckline of the gown body,
wherein the gown body and tubular protective sleeve are fabricated of a material and assembled to one another creating an impervious barrier to biomedical hazardous materials.

US Pat. No. 10,188,473

WIRE DRIVING DEVICE AND MANIPULATOR

OLYMPUS CORPORATION, Tok...

1. A wire driving device comprising:a pair of wires, one end of each individual wire in the pair of wires being attached to a movable member for antagonistically driving the movable member;
a pair of pulleys, an other end of each individual wire in the pair of wires being secured to an individual pulley in the pair of pulleys, each individual wire being wound around a respective one of each individual pulley;
a pair of driven gears, each driven gear in the pair of driven gears being coaxially secured to a respective one of each individual pulley;
a drive gear that is connected to a driving source that generates motive power; and
a pair of movable gears, each individual movable gear of the pair of movable gears being disposed between the drive gear and a respective one of each individual driven gear, each individual movable gear transmitting the motive power of the driving source to the respective driven gear from the drive gear,
wherein each individual movable gear is provided in a movable manner so that the pair of movable gears engage with the drive gear and with each respective individual driven gear when the drive gear is rotated in a manner in which the pair of pulleys wind a respective wire, and so that engagement of one individual movable gear with at least one of the drive gear and a respective individual driven gear is released when the drive gear is rotated in a manner in which a respective pulley unwinds a respective wire.

US Pat. No. 10,188,472

MEDICAL ROBOTIC SYSTEM WITH COUPLED CONTROL MODES

Intuitive Surgical Operat...

1. A system comprising:an imaging system having a field of view;
a slave manipulator adapted to manipulate a device when the device is coupled to the slave manipulator; and
a device controller automatically commanding the slave manipulator to move a working end of the device until the working end is within the field of view of the imaging system, after receiving an indication to do so.

US Pat. No. 10,188,471

TELE-OPERATIVE SURGICAL SYSTEMS AND METHODS OF CONTROL AT JOINT LIMITS USING INVERSE KINEMATICS

INTUITIVE SURGICAL OPERAT...

1. A tele-operation control method comprising:receiving a first manipulation command to move a distal end effector of a manipulator arm to a desired first position within a workspace, the manipulator arm extending between a proximal base and the distal end effector;
calculating a joint movement of one or more joints of a master control corresponding to calculated movement of a plurality of joints of the manipulator arm using inverse kinematics of the manipulator arm; and
when a first joint of the plurality of joints is at a joint range-of-motion (ROM) limit of the first joint, modifying an input variable within the inverse kinematics of the manipulator arm to lock the first joint, wherein the input variable corresponds to movement of the first joint within the workspace so that the calculated joint movement of the one or more joints of the master control provides improved force feedback.

US Pat. No. 10,188,469

INSTRUMENT, MANIPULATOR SYSTEM, AND CONTROL METHOD OF INSTRUMENT

OLYMPUS CORPORATION, Tok...

1. A manipulator system comprising:a medical instrument configured to be inserted into a body;
a manipulator configured to hold a portion of the instrument positioned in the body;
a switch configured to detect whether or not the manipulator holds the portion of the instrument positioned in the body;
an instruction-receiving part configured to detect an instruction for operating the instrument; and
a controller comprising hardware, the controller being configured to operate the instrument based on the instruction from the instruction-receiving part only when the switch detects that the manipulator holds the portion of the instrument positioned in the body,
wherein the switch detects whether or not the manipulator holds the portion of the instrument positioned in the body according to a conduction state and a cutoff state between a pair of contacts,
the switch switches the conduction state and the cutoff state between the pair of contacts by being pressed in a reference direction,
the manipulator has a gripper that grips the switch in the reference direction,
the instrument comprises a first instrument and a second instrument, and the controller is configured to:
operate only the first instrument where the instruction-receiving part detects the instruction when the switch detects whether or not the manipulator holds a portion of the first instrument positioned in the body, and
operate only the second instrument where the instruction-receiving part detects the instruction when the switch detects whether or not the manipulator holds a portion of the second instrument positioned in the body.

US Pat. No. 10,188,465

AUTOMATIC ENT SURGERY PREPLANNING USING A BACKTRACKING MAZE PROBLEM SOLUTION

Biosense Webster (Israel)...

1. A method, comprising:(a) receiving a computerized tomography (CT) scan of at least a part of a body of a patient;
(b) identifying voxels of the scan that correspond to regions in the body;
(c) displaying the scan on a screen and marking thereon selected start and termination points for a probe inserted in the body;
(d) finding a path from the start point to the termination point comprising a connected set of the identified voxels that are traversable by the probe, wherein finding the path comprises determining a set of density data associated with each of the identified voxels, determining a traversable density range, and determining the connected set of the identified voxels based at least upon the set of density data associated with those voxels being within the traversable density range;
(e) using the scan to generate a representation of an external surface of the body and displaying the representation on the screen;
(f) selecting a first region of the representation of the external surface to be transparent, wherein the first region is associated with the path such that the path is viewable through the first region;
(g) selecting a second region of the representation of the external surface to be non-transparent;
(h) rendering the first region transparent in the displayed representation, so as to make visible on the screen an internal structure of the body in a vicinity of the path; and
(i) rendering the second region non-transparent while rendering the first region transparent;
wherein the traversable density range comprises at least one density other than the density of air.

US Pat. No. 10,188,464

SENSOR-BASED SHOULDER SYSTEM AND METHOD

Zimmer, Inc., Warsaw, IN...

1. Method for providing graphical feedback visualizing forces within a joint through a range of motion of the joint, the method comprising:receiving, using one or more processors, position data for at least one bone of the joint while the at least one bone is moved through a range of motion (ROM);
concurrently to receiving the position data, receiving, using one or more processors, force data from at least one force sensor embedded within a trial prosthesis in the joint;
generating, for display on a display device, a graphical representation based on the position data and the force data, the graphical representation illustrating changes in the force data versus locations of the bone as it moved through the ROM; and
comparing the graphical representation with pre-generated target graphical presentation to determine whether the trial prosthesis provides target joint tension throughout the range of motion.

US Pat. No. 10,188,463

BONE LENGTH DETERMINATION

Stryker European Holdings...

1. A method for measuring an actual length of a fractured bone, wherein an implant is already introduced into the fractured bone, wherein a first reference body and a second reference body are already arranged in a predetermined relation to the implant, the method comprising the steps of:receiving a first 2D fluoroscopic image including the first reference body and a first bone feature;
determining a first spatial relation between the first reference body and a first end point at the first bone feature;
receiving a second 2D fluoroscopic image including the second reference body and a second bone feature;
determining a second spatial relation between the second reference body and a second point (P) at the second bone feature;
receiving data of a bone model having corresponding first and second bone features, determining a third spatial relation between the second point (P) of the second bone feature and a second end point (EP1) at the bone model; and
determining the actual length of the fractured bone based on the first, second, and third spatial relation, and on the predetermined relation of the reference bodies to each other.

US Pat. No. 10,188,462

IMAGE-GUIDED THERAPY OF A TISSUE

MONTERIS MEDICAL CORPORAT...

1. A method for effecting thermal therapy using an in vivo probe, comprising:positioning the probe in a volume in a patient;
identifying a three-dimensional region of interest at which to apply thermal therapy;
identifying, by processing circuitry, a treatment profile for effecting thermal therapy to the three-dimensional region of interest,
wherein the treatment profile comprises a plurality of target positions,
wherein each target position of the plurality of target positions is associated with one or more of a respective power level, a respective energy level, a respective emission pattern, a respective time period, and a respective geometry of a target area of the three-dimensional region of interest, and identifying the treatment profile comprises calculating the plurality of target positions as a sequence of positions and alignments of the probe based on a symmetric or asymmetric output pattern of the probe and selecting for the treatment profile a selected sequence corresponding to at least one of a minimum number of positions of the probe, and a minimum treatment time for effecting the thermal therapy to the three-dimensional region of interest based on expected output of the probe,
wherein a desired trajectory of the probe is selected so as not to interfere with imaging equipment prior to the insertion of the probe into the volume; and
applying, by the processing circuitry, thermal therapy to the volume using the probe according to the treatment profile, wherein applying the thermal therapy comprises
a) activating delivery of therapeutic energy by the probe to the three-dimensional region of interest at a first target position of the plurality of target positions according to the treatment profile,
b) causing actuation of the probe to adjust at least one of a linear position and a rotational position of the probe to a next target position of the plurality of target positions in accordance with the sequence of positions and alignments of the probe for each of the plurality of target positions in the treatment profile,
c) activating delivery of therapeutic energy to the three-dimensional region of interest at the next target position according to the treatment profile, and
d) repeating steps (b) and (c) until therapeutic energy is delivered to at least a first volume of the three-dimensional region of interest.

US Pat. No. 10,188,460

CHOKED DIELECTRIC LOADED TIP DIPOLE MICROWAVE ANTENNA

Covidien LP, Mansfield, ...

1. A microwave antenna assembly, comprising:a feedline including an inner conductor, an outer conductor and an inner insulator disposed therebetween;
a radiating section coupled to the feedline, the radiating section including:
a dipole antenna having a proximal portion and a distal portion and a feed point having a dielectric material therebetween; and
a tubular dielectric loading disposed about the dipole antenna, a dielectric permittivity of the tubular dielectric loading is higher than a dielectric permittivity of the dielectric material of the feed point; and
a choke disposed around at least a portion of the feedline, the choke including an inner dielectric layer and a tubular structure having an inner cylindrical casing and an outer cylindrical casing defining a cavity therebetween configured to supply a dielectric coolant to the radiating section, the inner dielectric layer extending distally past a distal end of the tubular structure.

US Pat. No. 10,188,459

ABLATION CATHETER WITH FLEXIBLE ELECTRODE

ST. JUDE MEDICAL, ATRIAL ...

1. An ablation catheter comprising a catheter body and a hollow elongate electrode disposed at a distal end of the catheter body, the electrode comprising an axial length and a sidewall provided with one or more elongate gaps extending therethrough, the one or more elongate gaps configured to provide flexibility in the sidewall and to allow shortening of the electrode axial length when a force is applied to the electrode in an axial direction.

US Pat. No. 10,188,453

SURGICAL INSTRUMENT WITH CONTAINED DUAL HELIX ACTUATOR ASSEMBLY

Ethicon LLC, Guaynabo, P...

1. A surgical instrument, comprising:(a) a handle assembly including a rotary member rotatably extending along an axis of rotation;
(b) an end effector;
(c) a shaft assembly defining a longitudinal axis, wherein the longitudinal axis is parallel to the axis of rotation of the rotary member, wherein the shaft assembly includes:
(i) a distal end portion, wherein the end effector is positioned at the distal end portion of the shaft assembly,
(ii) a proximal end portion associated with the handle assembly,
(iii) an articulation section positioned between the distal and proximal end portions and configured to articulate the distal end portion relative to the proximal end portion to deflect at least part of the end effector positioned at the distal end portion away from the longitudinal axis,
(iv) a first lead member operatively connected between the rotary member and the articulation section and configured to translate longitudinally a first longitudinal direction, and
(v) a second lead member operatively connected between the rotary member and the articulation section and configured to translate longitudinally a second longitudinal direction, wherein the second longitudinal direction is simultaneous and opposite the first longitudinal direction,
wherein the rotary member is configured to be selectively rotated about the axis of rotation to direct the first and second lead members in the first and second longitudinal direction and thereby articulate the articulation section for deflecting the end effector.

US Pat. No. 10,188,443

BONE CEMENT MIXING AND DELIVERY DEVICE

1. A bone cement mixing and delivery device, comprising:a shaft defining a passageway;
a connector comprising a central portion that is coupled to the shaft, the central portion defining a channel that is in communication with the passageway, the connector comprising first and second ports that extend from the central portion, the ports each defining a lumen that is in communication with the channel;
a first cartridge coupled to the first port and a second cartridge coupled to the second port, the first cartridge comprising a first component of a bone cement and the second cartridge comprising a second component of the bone cement;
a first syringe coupled to the first cartridge;
a second syringe coupled to the second cartridge; and
a plunger that extends into the channel to move the first and second components from the channel and into the passageway.

US Pat. No. 10,188,439

BONE FIXATION SYSTEM

DePuy Synthes Products, I...

1. A bone fixation linkage comprising:first and second links configured to interconnect with one another in an unlocked position such that the first and second links angulate with respect to one another, each link defining a first surface configured to face a bone to which the bone fixation linkage is configured to be attached, a second surface opposite the first surface along a first direction, a first attachment member, a second attachment member spaced from the first attachment member along a second direction, perpendicular to the first direction, a first fixation hole that extends through the first attachment member, and a second fixation hole that extends through the second attachment member, the second fixation hole having a diameter greater than that of the first fixation hole,
wherein the first attachment member of each respective link defines a first geometry at the first surface of the respective link, the second attachment member of each respective link defines a second geometry at the second surface of the respective link, and the first geometry of the first link is configured to interlock with the second geometry of the second link when the first and second links are in a locked position so as to prevent relative angulation between the first and second links, and
wherein the first link has a first interior surface that defines the first fixation hole of the first link, and the first attachment member of the first link has a tapered surface that extends from the first interior surface to the second surface of the first link and surrounds the first fixation hole of the first link.

US Pat. No. 10,188,437

SPINE STABILIZATION

Globus Medical, Inc., Au...

1. A surgical system comprising:an intervertebral device; and
a compression device, wherein the compression device comprises:
a receiver member, the receiver member including a limiter; and
an insert member configured to be received in the receiver member, the insert member including a catch configured to engage the limiter,
wherein the insert member comprises an opening configured to receive a pin,
wherein the receiver comprises a channel configured to engage the pin, and
wherein the pin is configured to travel within the channel to constrain movement of the receiver member relative to the insert member prior to the catch engaging the limiter so that receiver and insert remain in an interconnected state, and
wherein the compression member is configured to allow a dynamic range of compression such that the length of the compression member can increase or decrease following an initial amount of static compression.

US Pat. No. 10,188,434

HYBRID MULTIFUNCTIONAL POSTERIOR INTERSPINOUS FUSION DEVICE

The University of Toledo,...

1. An interspinous stabilization device comprising:a body portion having a first end and a second end, the body portion comprising a rear wall at the first end connected to opposed upper side walls and opposed lower side walls, and a slit extending between upper surfaces of the lower side walls and lower surfaces of the upper side walls, wherein the opposed upper side walls are unconnected except at the first end, and the opposed lower side walls are unconnected except at the first end;
a pair of mounting plates supported on the body portion and adapted to engage a first vertebra; and
a pair of connecting plates supported on the body portion and adapted to engage a second vertebra, wherein the connecting plates have respective apertures;
wherein the rear wall defines a spring-like hinge between the pair of mounting plates and the pair of connecting plates; and
wherein the interspinous stabilization device is adapted to maintain continued axial loading of a graft disposed between the first and second vertebra as settling of the graft occurs.

US Pat. No. 10,188,433

ANTERIOR CERVICAL PLATES FOR SPINAL SURGERY EMPLOYING ANCHOR BACKOUT PREVENTION DEVICES, AND RELATED SYSTEMS AND METHODS

1. An anterior cervical plate, comprising:a main body including
a front surface,
a rear surface opposite the front surface, wherein the rear surface is configured to face first and second vertebrae, and
inner surfaces connected to the front and the rear surfaces, wherein the inner surfaces form a first anchor passageway and a second anchor passageway through the main body, wherein the first and the second anchor passageways are configured to respectively receive first and second anchors; and
a positioning guide projecting from the rear surface and configured such that, when the rear surface abuts against an anterior surface of the first vertebra and the positioning guide abuts against an endplate of the first vertebra, the positioning guide positively aligns the first anchor passageway relative to a corner edge of the first vertebra and the positioning guide is configured to be free from abutment against the second vertebra,
wherein the positioning guide includes a magnet configured to create a magnetic field.

US Pat. No. 10,188,431

DOUBLE-HEADED PEDICLE SCREW

1. A double-headed pedicle screw comprising:a threaded shaft portion having an upper end, the upper end having a first side and an opposing second side, the first side having a first side protrusion and the opposing second side having a second side protrusion; and
a first yoke assembly extending from the first side of the upper end of the threaded shaft portion;
a second yoke assembly extending from the opposing second side of the upper end of the threaded shaft portion, each of the first and second yoke assemblies including a recess configured to receive a portion of a rod therein, the recess of the first yoke assembly and the recess of the second yoke assembly each having an opening facing in a direction away from the other yoke assembly;
wherein the first side protrusion is configured to receive the first yoke assembly and the second side protrusion is configured to receive the second yoke assembly, the first side protrusion and the second side protrusion aligned along a common axis, each of the first and second yoke assemblies configured for pivoting movement relative to the threaded shaft portion independent of the pivoting movement of the other yoke assembly and wherein the first and second yoke assemblies are configured for pivoting movement in a direction perpendicular to the common axis of the first and second side protrusions.

US Pat. No. 10,188,387

ARTICULATING APPARATUS FOR ENDOSCOPIC PROCEDURES

Covidien LP, Mansfield, ...

1. A surgical device, comprising:an elongate body portion including an inner actuation shaft movably positioned therewithin and repositionable between a first position and a second position, the inner actuation shaft including an engagement member;
an end effector releasably supported adjacent a distal end of the elongate body portion, the end effector including:
an engagement member corresponding to the engagement member of the inner actuation shaft to facilitate releasable connection of the end effector to the elongate body portion, the end effector being releasable from the elongate body portion when the inner actuation shaft is positioned in the second position and secured to the elongate body portion when the inner actuation shaft is positioned in the first position;
a plurality of surgical anchors; and
a pair of opposed longitudinally extending tines defining a pair of opposed longitudinally extending channels; and
an outer tube, wherein the inner actuation shaft is movably positioned within the outer tube, wherein the engagement of the inner actuation shaft is concealed within the outer tube in the first position and exposed from the outer tube in the second position.

US Pat. No. 10,188,374

PNEUMOPERITONEUM DEVICE

Atropos Limited, Bray, C...

1. A method of performing a medical procedure, comprising:excising tissue within a body cavity, wherein the tissue is excised with the body cavity in an insufflated state;
inserting a bag into the body cavity;
delivering the excised tissue into an interior of the bag, wherein the excised tissue is delivered into the interior of the bag through a first access channel of the bag; and
performing a procedure on the tissue in the interior of the bag, wherein the procedure is performed with the bag in an insufflated state and the body cavity in an uninsufflated state, and wherein performing the procedure includes accessing the interior of the bag through the first access channel, accessing the interior of the bag through a second access channel of the bag, and manipulating the tissue in the interior of the bag through at least one of the first and second access channels.

US Pat. No. 10,188,373

STEERABLE LASER PROBE

Katalyst Surgical, LLC, ...

1. A method for performing an ophthalmic procedure comprising:compressing an actuation structure of a handle wherein the handle has a handle distal end and a handle proximal end and wherein the actuation structure has an actuation structure distal end, and an actuation structure proximal end, and a plurality of actuation arms and wherein each actuation arm of the plurality of actuation arms has at least one extension mechanism and an inverted actuation joint, wherein the actuation structure has an actuation ring, an actuation mechanism housing disposed in the actuation ring, and an actuation mechanism disposed in the actuation mechanism housing;
extending the actuation ring relative to a handle base of the handle;
extending the actuation mechanism relative to the handle base;
extending a wire relative to a housing tube wherein the wire has a wire distal end, a wire proximal end, and a pre-formed curve and wherein the housing tube has a housing tube distal end and a housing tube proximal end;
curving an optic fiber wherein the optic fiber has an optic fiber distal end and an optic fiber proximal end;
curving a flexible tube wherein the flexible tube has a flexible tube distal end and a flexible tube proximal end;
aiming the optic fiber distal end at a first surgical target; and
transmitting a light through the optic fiber.

US Pat. No. 10,188,363

MEDICAL IMAGING DEVICE, TUBE VOLTAGE SETTING DEVICE, IMAGING CONTROL METHOD, AND RECORDING MEDIUM STORING IMAGING CONTROL PROGRAM

FUJIFILM CORPORATION, To...

1. A medical imaging device comprising:a press plate that presses a breast;
an emitter that radiates radiation onto the breast;
an acquisition section that acquires various information indicating a type of an acoustic matching member inserted between the press plate and the breast in cases in which ultrasound imaging of the breast is performed; and
a setting section that sets a tube voltage of the emitter to a first tube voltage, in cases in which radiographic imaging of the breast is performed alone, and that sets the tube voltage of the emitter to a second tube voltage that is different from the first tube voltage, by employing the various information acquired by the acquisition section, in cases in which radiographic imaging and ultrasound imaging of the breast are performed consecutively with the acoustic matching member still inserted.

US Pat. No. 10,188,361

SYSTEM FOR SYNTHETIC DISPLAY OF MULTI-MODALITY DATA

Siemens Healthcare GmbH, ...

1. A computer-implemented method for providing a multi-modality visualization of a patient, the method comprising:receiving one or more image datasets, each image dataset corresponding to a distinct image modality;
segmenting the one or more image datasets into a plurality of anatomical objects;
receiving a list of clinical tasks associated with displaying the one or more image datasets;
for each anatomical object, using a machine learning model to determine visualization parameters for the anatomical object based on the list of clinical tasks; and
creating a synthetic display of the one or more image datasets by presenting each anatomical object according to its corresponding visualization parameters.

US Pat. No. 10,188,349

FLOORMAT PHYSIOLOGICAL SENSOR

TOSENSE, INC., San Diego...

1. A system for measuring a cardiac output value from a patient, comprising:a base comprising a bottom surface configured to rest on or near a substantially horizontal surface, and a top surface configured to receive at least one of the patient's feet;
an electrical impedance system connected to the top surface, the electrical impedance system comprising at least four electrodes, at least one of which is configured to inject an electrical current into the patient's feet, and at least one of which is configured to measure a first set of signals induced by the electrical current and representative of an impedance plethysmogram;
a heart rate monitoring system connected to the top surface and comprising at least two electrodes connected to a differential amplifier, the differential amplifier configured to measure a second set of signals representative of a cardiac rhythm from the patient; and
a processing system in electrical contact with the electrical impedance system and the heart rate monitoring system, and configured to: 1) receive the first signals from the electrical impedance system and convert them into a set of impedance values; 2) analyze the set of impedance values to determine a stroke volume value; 3) receive the second set of signals from the heart rate monitoring system and convert them into a set of ECG values; 4) analyze the set of ECG values to determine a heart rate value; and 5) collectively process the stroke volume value and the heart rate value to determine the cardiac output value.

US Pat. No. 10,188,334

SENSITIVITY CALIBRATION OF IN VIVO SENSORS USED TO MEASURE ANALYTE CONCENTRATION

Abbott Diabetes Care Inc....

1. A method, comprising:determining a sample lot sensitivity associated with a plurality of analyte sensors in a manufacturing lot;
determining one or more sensor-specific correction factors for an analyte sensor in the manufacturing lot;
determining a sensor-specific sensitivity for the analyte sensor based on the one or more sensor-specific correction factors; and
calibrating analyte level data obtained by the analyte sensor based on the sensor-specific sensitivity.

US Pat. No. 10,188,325

WEARABLE, NONINVASIVE GLUCOSE SENSING METHODS AND SYSTEMS

1. A wearable apparatus for glucose sensing comprising:(a) a noninvasive glucose sensor, adapted to be in contact with or attached to a target tissue, comprising:
(i) an ultrasound generator configured to direct ultrasound pulses or waves into the target tissue, and
(ii) an ultrasound detector configured to:
(1) detect ultrasound pulses or waves reflected from the target tissue using reflection, focused reflection, refraction, scattering, polarization, transmission, confocal, interferometric, low-coherence, and/or a low-coherence interferometry technique, and
(2) generate a signal corresponding to the detected ultrasound pulses or waves,
(b) a processor configured to:
(i) receive the signal from the ultrasound detector,
(ii) measure:
(1) at least one time of flight of the ultrasound pulses or waves reflected from or transmitted through the target tissue evidencing boundaries or interfaces within the target tissue, and/or
(2) at least one dimension of the target tissue evidencing a specific tissue layer within the target tissue, wherein the dimension includes thickness, length, width, diameter, curvature, or roughness; and
(iii) determine a glucose concentration value from:
(1) the at least one measured time of flight, and/or
(2) the at least one measured dimension, and
(c) a feedback unit including a display and configured to display a current glucose value or a plot of glucose values versus time,
wherein the target tissue is associated with an arm, a forearm, a wrist, a shoulder, a hand, a palm, a finger, an abdomen, a chest, a neck, a head, an ear, an eye, a back, a leg, a foot, or mixtures and combinations thereof, and
wherein target tissue comprises a skin tissue, an eye tissue, a mucosal tissue, a nail bed, a lunula, a connective tissue, a muscle tissue, a blood vessel, a cartilage tissue, a tendon tissue, or mixtures and combinations thereof.

US Pat. No. 10,188,321

METHOD OF MEASURING ANIMAL HEALTH USING MOTION VECTOR ANALYSIS

Vium, Inc., San Mateo, C...

1. A method for measuring an animal health comprising the steps:(a) recording, using a camera, a series of image frames of an animal cage interior wherein the cage comprises the animal enrolled in a medical study;
(b) generating a reduced vector field from at least a subset of image frames from step (a) using optical flow analysis;
(c) selecting one or more maximum vector values from the vector field from step (b);
(d) computing a first-period maximum value for the one or more maximum vector values from step (c) over a first time period length;
(e) repeating steps (a) through (d) for multiple, sequential time periods having the first time period length, wherein the multiple, sequential time periods fall within a second time period;
(f) selecting a second-period maximum value set from all of the first-period maximum values computed from repeating step (d);
(g) computing a mean value from the values of the second-period maximum value set selected from step (f);
(h) computing a selected animal health metric from the set: {degree of arthritis, arthritis index, efficacy of a drug; efficacy of a disease treatment, probability likelihood of having a disease; expected time to die} by subtracting a baseline value from the mean value from step (g); and
(i) plotting the computed animal health metric from step (h) over time.

US Pat. No. 10,188,313

MAGNETIC RESONANCE IMAGING APPARATUS AND METHOD FOR MEASUREMENT SIGNAL ACQUISITION IN A MAGNETIC RESONANCE IMAGING APPARATUS

1. A magnetic resonance imaging apparatus comprising:a plurality of receiving antennas for receiving a plurality of reception signals;
a first superposition device comprising a first output and a second output, the first output and the second output each providing a mode formed by superposition of at least two of the reception signals; and
a local coil comprising a first frequency division multiplex device and a second frequency division multiplex device, the first frequency division multiplex device for transmitting an input signal present at a first input and an input signal present at a second input of the first frequency division multiplex device via a first transmission link on different frequency bands to a receiving unit,
wherein the first output of the first superposition device is connected to the first input of the first frequency division multiplex device and the second output of the first superposition device is in signal connection with a second transmission link, and
wherein the second output of the first superposition device is also connected to an input of the second frequency division multiplex device of the local coil.

US Pat. No. 10,188,308

METHOD OF IDENTIFYING THE SPATIAL DISTRIBUTION OF AREAS IN A SENSORY AREA OF BRAIN, PROGRAM, AND RECORDING MEDIUM THEREFOR

CANON KABUSHIKI KAISHA, ...

1. A method of identifying a spatial distribution of areas in a sensory area of brain by obtaining brain activity information from a human body of a subject to which a sensory stimulus is applied, comprising:determining a rough spatial distribution of at least one target area in a sensory area of cerebral cortex in each of a left hemisphere and right hemisphere of the brain;
applying a sensory stimulus to the target area by showing a video to the subject;
obtaining brain activity information using a brain activity measuring machine which measures brain activity in a region that includes the target area while the sensory stimulus is being applied to the target area;
calculating a correlation value between brain activity information of the target area in the left hemisphere and brain activity information of the target area in the right hemisphere using the obtained brain activity information; and
adjusting the determined rough spatial distribution of the target area to an adjusted spatial distribution of the target area in each of the left and right hemispheres so that the correlation value between brain activity information of respective target areas of an identical type in the adjusted spatial distribution in the left and right hemispheres increases.

US Pat. No. 10,188,282

SUBJECTIVE OPTOMETRY APPARATUS

NIDEK CO., LTD., Aichi (...

1. A subjective optometry apparatus comprising:a subjective measurer including a light projecting optical system for projecting a target light flux toward an examinee's eye, a corrective optical system including a right-left pair of a right-eye corrective optical system and a left-eye corrective optical system and disposed on an optical path of the light projecting optical system to modify an optical characteristic of the target light flux, and an optical member shared by a right-eye optical path including the right-eye corrective optical system and a left-eye optical path including the left-eye corrective optical system, the optical member for guiding the target light flux corrected by the corrective optical system to the examinee's eye, the subjective measurer subjectively measuring an optical characteristic of the examinee's eye; and
an objective measurer including a measurement optical system for emitting measurement light to a fundus of the examinee's eye and for receiving reflected light from the fundus, the objective measurer objectively measuring the optical characteristic of the examinee's eye via the optical member disposed on an optical path of the measurement optical system.

US Pat. No. 10,188,272

IMAGING CAPSULE

1. A capsule, comprising:a cyclically everting sleeve shaped to define a sleeve interior;
a fluid, configured to facilitate the everting of the sleeve, contained within the sleeve interior; and
a plurality of electrically-conductive coils coupled to the sleeve and configured to, when at least two of the coils are magnetized, advance the capsule within a lumen by applying an everting force to the sleeve,
wherein the coils are arranged in a plurality of rings running longitudinally along the sleeve.

US Pat. No. 10,188,267

DISTAL END STRUCTURE OF ENDOSCOPE

OLYMPUS CORPORATION, Tok...

1. A distal end structure of an endoscope, the distal end structure comprising:an opening of a treatment instrument insertion channel formed on a distal end of an insertion portion in the endoscope and including an opening having a long side and a short side, the long side having a length greater than a length of the short side;
a first wall extending in a direction parallel to the long side, the first wall being disposed at the distal end of the insertion portion; and
a second wall facing the first wall in a direction parallel to the short side and extending in a direction parallel to the long side direction such that the first and second walls sandwich the opening, the second wall being disposed at the distal end of the insertion portion, wherein
a first end surface of a top portion on the first wall and a second end surface of a top portion on the second wall are inclined such that a first inclination direction of the first end surface and a second inclination direction of the second end surface in the direction parallel to the long side are opposite to each other.

US Pat. No. 10,188,266

ENDOSCOPIC IMAGING DEVICE FOR REDUCING DATA AMOUNT OF IMAGE SIGNAL

OLYMPUS CORPORATION, Tok...

1. An imaging device comprising:an image sensor; and
a processor comprising hardware, wherein the processor is configured to:
receive information from an image processing device external to the imaging device, wherein the information indicates that the image processing device is configured to:
receive, in a transmission period defined by the image processing device, an image signal representing a single reading of a subject, illuminated by illumination light, performed by the image sensor; and
generate an observation image of a first type based on the image signal representing the single reading received;
in response to the information received:
control the image sensor to perform a plurality of readings of the subject, illuminated by the illumination light;
generate an image signal representing the plurality of readings, for generating an observation image of a second type,
wherein the processor is configured to control the image sensor, generate the image signal representing the plurality of readings, or both to reduce a data amount of the image signal representing the plurality of readings such that transmission of the image signal representing the plurality of readings to the image processing device is completed within the transmission period; and
control a communication interface to transmit the image signal having the data amount that is reduced to the image processing device within the transmission period.

US Pat. No. 10,188,265

FLEXIBLE INSERTION APPARATUS WITH INPUT DEVICE HAVING ACTUATOR FORCE CONTROL

OLYMPUS CORPORATION, Tok...

1. An endoscope apparatus comprising:an elongated inserting section having a curving section which has a neutral position and is curvable at an arbitrary angle and which is arranged near a distal end section;
an input device which is provided in an operating section arranged on a proximal end side of the elongated inserting section, has a neutral input position corresponding to an input to hold the curving section at the neutral position, and receives an arbitrary input to curve the curving section in a movable range including a first range that includes the neutral input position and a second range that has an operation amount from the neutral input position exceeding the first range, wherein the input device comprises:
a shaft section;
a dial section arranged on an end portion of the shaft section; and
a first gear section arranged on the shaft section;
a detecting sensor which detects a rotating direction and a rotation amount of the dial section which is an input to the input device;
a first actuator which is operated to curve the curving section at a certain curving angle;
a second actuator which gives a force towards the neutral input position to the input device; and
a controller configured to operate the first actuator to curve the curving section at a curving angle corresponding to an input amount to the input device, operate the second actuator to move the input device towards the first range, when the input amount to the input device is in the second range, and stop a drive of the second actuator, when the input amount to the input device moves into the first range,
the second actuator being arranged in the operating section,
a second gear section of the second actuator transmitting a rotation force of the second actuator to the input device via the first gear section.

US Pat. No. 10,188,258

MULTI-FUNCTION CLEANING TOOL

1. A cleaning tool comprising:handle having a longitudinal axis; and
a cleaning device having a longitudinal axis;
said cleaning device releasably securable to said handle and moveable between a first position where the longitudinal axis of said cleaning device is generally aligned with the longitudinal axis of said handle, and a second position where the longitudinal axis of the cleaning device is arranged at an angle relative to the longitudinal axis of said handle;
wherein said cleaning tool has first, second and third coupling mechanisms, said first and second coupling mechanisms offset by 90 degrees to each other and fixed to or integral with said handle, said third coupling mechanism fixed to or integral with said cleaning device and releasably and independently securable to said first and said second coupling mechanisms to releasably secure said cleaning device to said handle,
wherein when said third coupling mechanism is releasably secured to said first coupling mechanism, said cleaning device is positioned such that its longitudinal axis is generally aligned with the longitudinal axis of said handle,
wherein when said third coupling mechanism is releasably secured to said second coupling mechanism, said cleaning device is positioned such that its longitudinal axis is at an angle relative to the longitudinal axis of said handle; and
wherein said handle includes a lower portion and an upper portion, said lower portion pivotably connected to said upper portion, said lower portion including said first and second coupling mechanisms and having said longitudinal axis of said handle.

US Pat. No. 10,188,257

CEILING TEXTURE SCRAPING ASSEMBLY

1. A ceiling texture scraping assembly being configured to scrape and collect texture from a ceiling, said assembly comprising:a pan being configured to be manipulated having said pan being positioned beneath a ceiling, said pan having an outer wall and a pair of peripheral walls, said outer wall having a top side, a bottom side and a back side, said back side tapering to a point extending away from each of said bottom side and said top side, each of said top side and said bottom side having a distal edge with respect to said back side, said distal edge corresponding to each of said top side and said bottom side defining an opening into said pan wherein said opening is configured to receive texture from the ceiling, said bottom side having a length being greater than a length of said top side;
a sleeve being coupled to and extending away from said point parallel to said top side and said bottom side wherein said sleeve is configured to be gripped; and
a blade being coupled to said pan wherein said blade is configured to frictionally engage texture on the ceiling thereby facilitating said blade to remove the texture from the ceiling.

US Pat. No. 10,188,249

VACUUM CLEANER

LG Electronics Inc., Seo...

1. A vacuum cleaner system comprising:a cleaner body that defines a battery chamber;
a motor that is located in the cleaner body and configured to provide a suction force;
a battery that is detachably provided in the battery chamber and configured to provide electric power to the motor;
a battery cover that is rotatably coupled to the cleaner body and configured to open and close the battery chamber; and
a charging stand that is configured to couple to the cleaner body, wherein the charging stand includes an opening prevention rib that is located along an opening path of the battery cover to thereby prevent the battery cover from opening based on the cleaner body being coupled to the charging stand.

US Pat. No. 10,188,226

MODULAR COUNTER SERVICES DISPENSING SYSTEM

San Jamar, Inc., Elkhorn...

1. A food services accessory dispensing system comprising:a first base portion;
a plurality of dispensing containers that are each configured to dispense a different food service accessory, each of the plurality of dispensing containers being constructed to removably cooperate with the first base portion;
a second base portion constructed to removably cooperate with the first base portion and constructed to cooperate with at least one of the plurality of dispensing containers and wherein each alternate lateral end of each of the first base portion and the second base portion have the same shape;
a first opening and a second opening formed in the first base portion;
a first opening and a second opening formed in the second base portion; and
at least one connector having a first end and a second end, wherein the first end is releasably insertable into each of the first and second openings formed in the first base portion or the second base portion and the second end is releasably insertable into each of the first and second openings formed in the first base portion and the second base portion for selectively connecting the first base portion and the second base portion to one another when the connector is engaged with a respective one of the first and second openings in the first base portion and a respective one of the first and second openings in the second base portion when the respective lateral ends of the first base portion and the second base portion are directly adjacent one another.

US Pat. No. 10,188,219

MATTRESS

1. A mattress comprising:a layer of coil pockets comprising first and second coil pockets; each of said first and second coil pockets comprising a pocket and a coil spring disposed in said pocket; and
a first layer of cushion pockets comprising first and second cushion pockets; each of said first and second cushion pockets comprising a pocket and a cushion member disposed in said pocket; said first layer of cushion pockets further comprising an attachment member comprising an upper surface and a lower surface; said first and second cushion pockets being engaged with said upper surface of said attachment member; said lower surface of said attachment member being engaged with said layer of coil pockets such that said first and second cushion pockets act directly upon and only upon said first and second coil pockets, respectively.

US Pat. No. 10,188,217

COLLAPSIBLE BED FOUNDATION

1. A mattress foundation, comprising: a headboard end panel assembly having a first end and a second end; a footboard end panel assembly having a first end and a second end; a left side panel assembly having a first end and a second end; a right side panel assembly having a first end and a second end; and a top surface, disposed at a top edge of each of said headboard end panel assembly, said footboard end panel assembly, said left side panel assembly and said right side panel assembly, for supporting a mattress so as to prevent said mattress from sagging, wherein the first end of the left side panel assembly slidably engages with the first end of the headboard end panel assembly via a first sliding mechanism so as to form a first corner attachment, and the second end of the left side panel assembly slidably engages with the first end of the footboard end panel assembly via a second sliding mechanism so as to form a second corner attachment, wherein the first end of the right side panel assembly slidably engages with the second end of the headboard end panel assembly via a third sliding mechanism so as to form a third corner attachment, and the second end of the right side panel assembly slidably engages with the second end of the footboard end panel assembly via a fourth sliding mechanism so as to form a fourth corner attachment, wherein at least one of the first sliding mechanism, the second sliding mechanism, the third sliding mechanism, and the fourth sliding mechanism includes an elongated slot and an elongated protruding element that fits within said elongated slot, and wherein a horizontal cross-section of at least one of said elongated slot and said elongated protruding element includes thin elongated flexible arms, attached at their proximal ends to a common surface, but otherwise extending away from said common surface and separated from each other, for enhancing a friction fit, and wherein when viewed from said horizontal cross-section, an average thickness of said thin elongated flexible arms is substantially less than a length of said thin elongated flexible arms.

US Pat. No. 10,188,216

CONVERTIBLE CASE AND STOOL

1. A case convertible into a stool and a working surface, the case comprising:a worktable;
a front panel removably secured to a front side of the worktable;
a rear panel removably secured to a rear side of the worktable; and
a stool seat configured to secure the front and rear panels to the worktable in a carrying mode wherein the case is fully assembled,wherein in a working mode the case is fully disassembled and the front and rear panels are removed from the worktable and interconnected to form a supporting substructure of the stool and the stool seat is removably extended from the first panel of the supporting substructure to the second panel of the supporting substructure to define a sitting surface.

US Pat. No. 10,188,212

BLOW MOLDED RESIN FURNITURE HAVING A STABILIZING BOX STRUCTURE

Suncast Technologies, LLC...

1. A resin furniture assembly comprising:a box structure, formed by a first end structure including a first side panel, having an inner wall, an outer wall, and a plurality of edge walls integrally connected to each other, a second end structure including a first side panel, having an inner wall, an outer wall, and a plurality of edge walls, a front panel, a rear panel, a base panel and a seat panel to include a hollow interior portion, said box structure including a plurality of legs for supporting a bottom surface of said base panel in a spaced apart relationship above a ground surface so that an air gap is maintained between said bottom surface of said base panel and a ground surface, a back panel, said back panel secured to said box structure to form a seat back, said seat panel secured to said box structure for enclosing the top portion of said box structure, at least one of said first end structure, said second end structure, said front panel, said rear panel, or said seat panel being pivotally secured to said box structure for movement between a closed position enclosing said box structure and an open position providing access to an inner portion of said box structure, said inner portion of said box structure providing an enclosed storage area, a rain gutter integrally formed on said inner wall of each said end structure, each said rain gutter providing support to side portions of said seat panel to channel water away from hollow interior portion of said box structure to keep contents stored therein dry;
wherein said seat panel includes a rain gutter bead integrally formed thereto said rain gutter bead cooperating with said rain gutter to channel water away from hollow interior portion of said box structure to keep contents stored therein dry.

US Pat. No. 10,188,205

STRUCTURAL ELEMENT

1. A structural furniture element, having at least one frame which comprises four frame elements (101, 102, 103), whereineach said frame element (101, 102, 103) has at least one limb (V) extending from top to bottom
one or more struts (L1, L2) extend from the limb (V) of a first frame element (101, 102, 103) to a limb (V) of a second frame element (101 102, 103), with each said strut (L1, L2) having an upper side inclined relative to a horizontal,
additionally comprising a hinge (31), with the frame elements (101, 102, 103) each being fixedly connected to the hinge (31) and positionable at different angles relative to one another by the hinge (31),
the structural furniture element has opposite first and second sides, and
at least one or more first struts (L1, L2) is located on the first side and one or more second, struts (L1, L2) is located on the second side, with the oppositely-positioned first and second struts (L1, L2) being positioned such that the upper sides thereof are inclined downwardly to the horizontal and toward the inner side of the structural furniture element.

US Pat. No. 10,188,200

MODULAR DESIGNED POOL CLEANING TOOL

1. A modularly designed cleaning tool, comprising:a brush head comprising an elongate frame and bristles extending therefrom, said elongate frame having an upper surface, a lower surface, and two sidewalls extending therebetween, wherein the elongate frame comprises:
a middle portion;
a first distal portion connected to the middle portion; and
a second distal portion connected to the middle portion opposite the first distal portion,
wherein the first distal portion and the second distal portion extend from the middle portion at a first angle and a second angle, respectively, such that the lower surface at the first and second distal portions are angled relative to the lower surface at the middle portion,
wherein the distal ends of the bristles together form a cleaning surface along the middle portion and the first and second distal portions of the elongate frame;
a stem assembly having a tubular configuration and extending outwardly from the brush head at an angle from the bristles, wherein the stem assembly and the brush head define a neck area,
wherein the bristles extend from the lower surface at the middle portion such that the cleaning surface extends substantially perpendicular to the stem assembly along the middle portion, and wherein the bristles extend from the lower surface at the first and second distal portions such that the cleaning surface along the first and second distal portions is angled relative to the cleaning surface along the middle portion;
removable corner brushes each having a proximal end and a distal end, an upwardly curved surface near the distal end, the removable corner brushes each configured to receive the first or second distal portion of the elongate frame so that the removable corner brushes are detachably connected to the elongate frame,
wherein the removable corner brushes comprise bristles extending generally away from the upwardly curved surface of the removable corner brushes in a manner such that bristles adjacent the distal end of the removable corner brushes extend outwardly at an angle different from the angle which bristles disposed at the first and second distal portions of the elongate frame extend to form an additional cleaning surface at the removable corner brushes, with the removable corner brushes on the elongate frame, and
wherein the upwardly curved surface is angled relative to the corresponding lower surface at the first or second distal portion of the elongate frame with the associated removable corner brush on the elongate frame, such that the lower surface at the middle portion extends at a first angle relative to the stem assembly, the lower surface at the first and second distal portions extends at a second angle relative to the stem assembly, and the upwardly curved surface extends a third angle relative to the stem assembly, wherein the first, second, and third angles are different angles relative to the stem assembly; and
at least one magnetic component disposed on an exterior surface of the removable corner brushes such that the magnetic component is positioned adjacent a front of the brush head, said magnetic component positioned to pick up magnetic debris in water in a manner such that the magnetic debris does not adhere to the cleaning surface.

US Pat. No. 10,188,198

FINGER RETENTION CLIP

1. A finger retention clip for retaining an object about a user's finger, comprising:a base member adapted for attachment to the object; and
a resilient retaining member attached to the base member, the retaining member forming an open finger loop and being sized and shaped to conform to the user's finger;
wherein the retaining member has a first width, and a second width narrower than the first width;
wherein the retaining member includes a structural feature that selectively provides a stress concentration, such that the retaining member releases from the user's finger in response to a selected force by breaking of the retaining member.

US Pat. No. 10,188,194

TWISTED COSMETIC BRUSH

1. A cosmetic brush comprising:a polymer core extending along a longitudinal axis and defining a first portion thereof extending between a first end of the first portion and a second end of the first portion;
a plurality of polymer bristles extending from the polymer core in a radial direction, wherein at least the first end of the first portion of the core is twisted about the longitudinal axis relative to the second end of the first portion of the core to define a twisted portion and wherein bristles in the twisted portion are arranged in one or more columns disposed in one or more spiral or helical paths about at least a portion of the longitudinal axis of the core, the plurality of polymer bristles integrally molded with the polymer core,
wherein the molded polymer core is twisted with a plurality of twist angles via an application of heat such that the plurality of polymer bristles have an organized randomness,
wherein an upper most bristle in the twisted portion is offset from a lower most bristle in the twisted portion by one of the plurality of twist angles,
wherein the twist angles are angles between two bristles in different rows within the twisted portion,
wherein the molded polymer core is twisted with the plurality of twist angles throughout the entire twisted portion, and
wherein the plurality of twist angles are distinct from each other.

US Pat. No. 10,188,192

APPARATUS AND METHODS FOR MODIFYING KERATINOUS SURFACES

1. An apparatus for treating human skin, comprising:a. an applicator head comprising one or more applicator nozzles;
b. a reservoir comprising a treatment composition, wherein the treatment composition comprises particles and has a particle settling rate of less than 0.03 mm per day at 25° C. and 1 atm pressure, and an elastic modulus between about 0.1 Pa to about 1000 Pa at 25 C and 1000 Hz;
c. a sensor;
d. a CPU;
wherein the sensor takes an image of at least 10 ?m2 of skin; the CPU analyzes the image to calculate one or more localized L values of individual pixels or group of pixels; the CPU then compares the local L value to a predetermined background L value to identify skin deviations where the difference between the background L value and the local L value is greater than a predetermined ?Ls value.

US Pat. No. 10,188,187

PURSE PROTECTING APPARATUS AND ASSOCIATED USE THEREOF

7. A method of utilizing a combined purse and security fastener for securing said purse around a user neck and a user shoulder, thus preventing theft of said purse, while also affording comfort when carrying said purse over the user shoulder, said method comprising the chronological steps of:providing a purse including a storage section and a flexible shoulder strap affixed thereto;
carrying said flexible shoulder strap over a first shoulder of the user such that a weight of said purse is supported on the first shoulder of the user;
providing a security fastener including a flexible chain and a shoulder pad adjustably engaged with said flexible chain;
lifting each of said flexible chain and said shoulder pad up and over a user neck opposite to said first shoulder of the user;
resting said shoulder pad on a second shoulder of the user opposite to said first shoulder of the user such that a weight of said security fastener is supported on the second shoulder of the user;
slidably coupling said security fastener to said flexible shoulder strap by looping a proximal end of said flexible chain through said flexible shoulder strap while holding a distal end of said flexible chain adjacent to said storage section; and
fastening said proximal end of said flexible chain to said distal end of said flexible chain such that said flexible chain rests along a first axis during use and said flexible shoulder strap rests along a second axis during use, wherein said first axis intersects said second axis, wherein said flexible chain overlaps said flexible shoulder strap.

US Pat. No. 10,188,186

DIAPHRAGM GAME CALL CASE

1. A container for housing a diaphragm game call, the container comprising:a case having a first member defining a first interior, and a second member defining a second interior;
a connector that adjoins a portion of said first member to a portion of said second member, so that said first interior and said second interior together define an interior space sized to enclose the diaphragm game call;
a fastener for closing said first member and said second member to enclose said interior space of the container;
a mount directly attached to said first member and being constructed of a water impervious material to prevent fluid from leaking through the mount;
a first compressible moisture-retaining material attached to said mount; and
a second compressible moisture-retaining material attached to said second member, the second compressible moisture-retaining material being comprised of a substantially similar material as the first compressible moisture-retaining material, forming a compression space within the interior space and between said first compressible moisture-retaining material and said second compressible moisture-retaining material, said compression space for storage of the diaphragm game call in contact with and compressed between said first compressible moisture-retaining material and said second compressible moisture-retaining material.

US Pat. No. 10,188,185

SUITCASE

1. A suitcase, comprising:a main body, comprising a containing groove;
a removable compartment, movably located in the containing groove, wherein the removable compartment comprises:
a base layer;
a covering layer, covering the base layer;
at least one hole, located in the base layer;
an inner opening unit, movably connected to the covering layer, wherein the inner opening unit is used for allowing the covering layer to be opened or closed, and the base layer is exposed to the outside when the covering layer is opened;
at least one first main fastening unit, located in the containing groove, wherein the at least one first main fastening unit comprises:
a fastening bar; and
an operating unit, connected to the fastening bar and passing through the at least one hole;
at least one second main fastening unit, located in the containing groove; and
a plurality of fastening rings, connected to the base layer, and a plurality of positions of the plurality of fastening rings respectively correspond to the at least one first main fastening unit and the at least one second main fastening unit.

US Pat. No. 10,188,181

FASTENER STRINGER AND SLIDE FASTENER PROVIDED WITH SAME

YKK Corporation, (JP)

1. A fastener stringer comprising a row of elements and a fastener tape, at least one side edge of the fastener tape having insulation properties, the row of the elements being attached to the one side edge of the fastener tape, wherein each element comprises a pair of leg portions for holding the fastener tape from front and back sides; and a head portion connecting each leg portion while straddling the one side edge of the fastener tape, the head portion having an engaging region for engaging with an opposing element when constructing a fastener chain; and wherein cured coating film is formed in 50% or more of a total number of the elements at least at a center portion in a front and back direction of the fastener tape on an end surface of the head portion.

US Pat. No. 10,188,180

SLIDER FOR SLIDE FASTENER

YKK Corporation, (JP)

1. A slide fastener slider, configured to move in a front-rear direction, and comprising a slider body having an upper blade and a lower blade connected by a guide post at front end sides thereof, and a pull tab attached to a pull tab attachment portion formed on the upper blade,wherein the pull tab attachment portion has a pair of right and left first members protruding from the upper surface of the upper blade, and a second member connecting the pair of the right and left first members, so as to form an insertion passage opening in the front-rear direction,
wherein the first members have a base portion and a wall portion arranged to extend from the base portion toward at least one of front and rear sides thereof, wherein the pull tab has a string-shaped member and the string-shaped member is inserted into the insertion passage in the front-rear direction and attached to the pull tab attachment portion, and
wherein the wall portions are arranged to extend toward the front sides beyond a front end of the second member or arranged to extend toward the rear sides beyond a rear end of the second member.

US Pat. No. 10,188,178

BUCKLE FOR SEATBELT DEVICE

AUTOLIV DEVELOPMENT AB, ...

1. A buckle for a seatbelt apparatus comprising:a buckle stay that has a fixation portion provided at a base end of the buckle stay and adapted to be fixed to a vehicle body, and a coupling plate portion provided at a leading end of the buckle stay and having a first through-hole;
a buckle base having a bottom plate portion and a pair of side plate portions standing up from opposite side edges of the bottom plate portion, the buckle base also having a second through-hole formed at one end of the bottom plate portion, the side plate portions extending in a longitudinal direction along the bottom plate to overlie a longitudinal position of the second through hole;
a support shaft inserted through the first and the second through-holes, the support shaft being loosely inserted through the first through-hole in the coupling plate portion, to allow the buckle base to be coupled to the buckle stay so as to be able to tilt with respect to the buckle stay through a predetermined angle in a first direction perpendicular to a plate surface of the bottom plate portion and further so as to be able to pivot with respect to the buckle stay, through a predetermined angle in a second direction parallel to the plate surface of the bottom plate portion;
an elastic member that when the buckle base tilts in the first direction and pivots in the second direction, urges the buckle stay to return the buckle base from a deflected position to an original position,
the support shaft integrally forming a generally cylindrical shaft main body and a pair of arm portions provided at an upper portion of the support shaft and extending from a longitudinal axis of the main body in opposing lateral directions, a lower end of the support shaft main body is collapsed against a lower surface of the bottom plate portion of the buckle base to fix the support shaft to the buckle base, the arm portions trapping the buckle stay between the arm portions and the buckle base, and
tip portions of the pair of arm portions are coupled into respective engagement grooves formed in the pair of side plate portions of the buckle base, the engagement grooves cooperating with the pair of arm portions to fix a rotational position of the support shaft relative to the buckle base, the support shaft fixed to the buckle base adjacent to the second through-hole to fixedly mount the support shaft to the buckle base bottom plate portion.

US Pat. No. 10,188,166

HELMET MOUNTED LIGHTING SYSTEM

1. A helmet mounted lighting system comprising:a housing comprising a mounting plate and a cover, the housing is configured to encase an electronic circuit, the electronic circuit comprises a power source, a switch, a capacitor, a logic board, and at least one light emitting diode;
wherein:
a bottom side of the mounting plate is contoured for attachment to a curved exterior surface of a helmet;
a top side of the mounting plate includes a receptacle thereon configured to receive the power source therein, the receptacle comprises a sidewall extending upwardly from the top side of the mounting plate, a top side of the sidewall includes a ledge thereon, the ledge is configured to support at least a portion of a printed circuit board on which the switch, the capacitor, the at least one light emitting diode, and the logic board are located;
the switch is configured to selectively energize the at least one light emitting diode;
the logic board, in conjunction with the switch, is configured to control the operation of the at least one light emitting diode; and
the capacitor is configured to regulate the light output of the at least one light emitting diode.

US Pat. No. 10,188,165

HEADGEAR CONFIGURED FOR POSITIONING OF SPECTACLES

1. Headgear configured for positioning of spectacles comprising:a first extending portion configured to extend under a chin;
a second extending portion configured for extending about a forward portion of a head;
a third extending portion configured for extending about a reward portion of the head;
a first opening in the second extending portion or third extending portion;
a second opening in the second extending portion or third extending portion;
a third opening in the second extending portion or third extending portion and spaced apart from the first opening;
a fourth opening in the second extending portion or third extending portion and spaced apart from the second opening;
the first opening and the third opening being configured and disposed to receive a first eyeglass temple on a first side of the head; and
the second opening and the fourth opening being configured and disposed to receive a second eyeglass temple on a second side of the head.

US Pat. No. 10,188,162

GARDENING UTILITY TOOL

1. An improved gardening utility tool comprising:a glove having a set of glove fingers and a glove thumb;
a set of finger extensions attached to a trank of the glove configured to have an open arrangement wherein the finger extensions are configured to move independently of each other;
a first portion included in each finger extension having a first resiliency;
a second portion included in each finger extension attached to the first portion having a second resiliency wherein a proof resilience of the second portion is higher relative to the first portion;
a set of pivots connecting each first portion to a corresponding second portion allowing the second portions to rotated about a long axis of the first portions;
a plurality of releasable connections disposed on adjacent side surfaces of the finger extensions wherein each of said finger extensions releasably interlocks with an adjacent said finger extension along said adjacent side surfaces to form a composite tool in which all of said finger extensions are locked together to move and operate together in a fixed arrangement;
a forward edge included in each finger extension having a shape taken from the group consisting of: flat, curved, concave, angled, concave angled, pointed, and any combination thereof; and,
a thumb extension attached to the trank.

US Pat. No. 10,188,161

GLOVES WITH SENSORY WINDOWS

1. A glove comprising:(a) an outer surface;
(b) an inner surface;
(c) finger portions; and
(d) an outwardly extending ridge on the inner surface of at least one of the finger portions, wherein the outwardly-extending ridge is between the DIP joint portion and the PIP joint portion, and the outwardly-extending ridge is configured to reduce slippage of the glove when on the hand.

US Pat. No. 10,188,158

WETSUITS WITH HYDRODYNAMIC INTERLOCKING AND KINESIOLOGIC FEATURES

Nike, Inc., Beaverton, O...

1. A wetsuit for aquatic activities, the wetsuit comprising:a base layer having a first surface and an opposite second surface;
a first backing layer having a first surface and an opposite second surface, the second surface of the first backing layer continuously secured to the first surface of the base layer, the first surface of the first backing layer forming an exterior surface of the wetsuit;
a second backing layer secured to the second surface of the base layer and forming at least a portion of an interior surface of the wetsuit; and
at least one sipe linearly extending from the first surface of the first backing layer comprising the exterior surface of the wetsuit through the first backing layer and into the base layer, the at least one sipe extending from an upper portion of a chest region of the wetsuit to a lateral portion of the chest region of the wetsuit.

US Pat. No. 10,188,157

INSULATED ATHLETIC SUPPORT GARMENT

1. An athletic garment, comprising:a waist band;
an insulated panel to conformally cover a groin and genital area of a person, at least one end of the insulated panel being coupled to a portion of the waistband;
a cord contained within a channel surrounding all but a top side of the insulated panel; and
a pair of slidably adjustable connectors on either side of the cord for tightening the insulated panel conformally against the groin and genital area of the person,
wherein the insulated panel is configured to insulate and protect the groin and genital area of the person against an ice bath when the person is submersed therein.

US Pat. No. 10,188,154

BRASSIERE UNDERWIRE REPAIR DEVICE

1. A system for repairing a brassiere having a fabric casing encompassing an underwire whose end tip section has poked a hole through the fabric casing, said system comprising:a hollow, elliptic, cylindrically shaped repair sleeve having an open bottom end and an enclosed rounded top end, and an outer layer of thermal adhesive; and
an installation apparatus, separate and independent from the repair sleeve, whereby the repair sleeve is configured to fit over the end tip section of the underwire and the installation apparatus is configured to be installed into the hole between the repair sleeve and an inner surface of the fabric casing to facilitate the installation of the repair sleeve entirely within the fabric casing.

US Pat. No. 10,188,151

INFANT SWADDLING

1. Infant swaddling comprising:a sheet made of a resilient, moisture-wicking material that maintains pressure on an infant and reduces excess moisture within the sheet when in use, the sheet configured to open to lay flat and defined by an outward-facing surface that, when the infant is placed on the sheet, faces away from the infant and an inner-facing surface that, when the infant is placed on the sheet, faces toward the infant, and the sheet comprising
an upper portion adjacent to an upper edge that, when in use, the infant's head extends beyond the upper portion at the upper edge;
a lower portion adjacent to a lower edge, the lower portion spaced apart from the upper portion;
a first laterally extending region adjacent to a first side edge, the outward-facing surface of the first laterally extending region comprising a first attachment having a first length;
a second laterally extending region adjacent to a second side edge, the inner-facing surface of the second laterally extending region comprising a second attachment that is recloseable with and complementary with the first attachment and having a second length, the first length being longer than the second length, wherein the first attachment and the second attachment are configured to allow adjustment to accommodate the infant's growth; and
wherein the lower portion comprises a loop, spaced apart from the lower edge, wherein the loop is fixed closer to the second side edge than the first side edge, wherein to close access through the lower portion, the lower portion is configured to be gathered and passed through the loop, wherein the loop is configured to reduce the possibility of the lower portion creeping during use, and wherein, when first attachment is closed with the second attachment, the lower portion is configured to be opened, allowing access to the infant near the infant's feet or bottom.

US Pat. No. 10,188,150

INFANT SWADDLING

1. Infant swaddling comprising:a pouch configured to hold and contact an infant when in use, wherein the pouch is made of a resilient, moisture-wicking material that comprises spandex fiber sufficient to maintain pressure on the infant and that reduces excess moisture within the pouch when in use,
the pouch further configured to open to lay flat when not in use to form a sheet, the sheet comprising an outward-facing surface that, when an infant is placed on the sheet, faces away from the infant and an inner-facing surface that, when an infant is placed on the sheet, faces toward the infant, a lateral axis extending from a first side edge to a second side edge of the sheet, and a vertical axis, perpendicular to the lateral axis, extending from an upper edge to a lower edge of the sheet, and the sheet comprising
an upper portion adjacent to the upper edge, wherein, in use, the infant's head extends beyond the upper edge, the upper portion comprising
a first side portion adjacent to the first side edge, the inner facing outward-facing surface of the first side portion comprising a first attachment having a first lateral length,
a second side portion adjacent to the second side edge, the second side portion opposite the first side portion, the inner-facing surface of the second side portion comprising a second attachment having a second lateral length, the second attachment is recloseable with and complementary with the first attachment, the first lateral length at least two times longer than the second lateral length to allow the pouch size to be adjusted to accommodate the infant's growth; and
a lower portion, adjacent to the lower edge,
wherein the lower portion comprises an elastic loop, spaced apart from the lower edge, wherein the elastic loop is fixed closer to the second side edge than the first side edge, wherein to close access to the pouch through the lower portion, the lower portion is configured to be gathered and passed through the elastic loop, wherein the elastic loop is configured to reduce the possibility of the lower portion creeping during use, and wherein, when first attachment is closed with the second attachment, the lower portion is configured to be opened, allowing access to the infant near the infant's feet or bottom.

US Pat. No. 10,188,149

PLACKET TRUSS AND GARMENT INCORPORATING THE SAME

1. A placket truss for use on a placket having a plurality of buttons sewn thereto with thread, said placket truss comprising:an elongate member including opposed end portions;
a medial clip integral with the elongate member and disposed between said opposed end portions, said medial clip including a bend whereby the medial clip doubles back onto the elongate member and extends in a direction transverse to a length of the elongate member; and
wherein each said end portion includes at least one slot sized and adapted to engage the thread of a corresponding button.

US Pat. No. 10,188,147

ATOMIZATION ASSEMBLY AND ELECTRONIC CIGARETTE

HUIZHOU KIMREE TECHNOLOGY...

1. An atomization assembly configured for forming an electronic cigarette with a battery assembly (4), comprising a suction nozzle assembly (1), an atomization core (2) and an e-liquid cup assembly (3), the atomization core (2) and the suction nozzle assembly (1) are respectively arranged at two ends of the e-liquid cup assembly (3); wherein the e-liquid cup assembly (3) comprises an e-liquid storage sleeve (31) and a vent pipe (32), the vent pipe (32) is arranged in the e-liquid storage sleeve (31) for discharging smoke obtained by an atomization of the atomization core (2) to the suction nozzle assembly (1), an e-liquid storage cavity (33) is formed between the e-liquid storage sleeve (31) and the vent pipe (32), one end of the e-liquid storage sleeve (31) is provided with an open end communicating with the e-liquid storage cavity (33), the atomization core (2) is detachably connected to the e-liquid cup assembly (3) and at least one end of the atomization core (2) is inserted into the e-liquid storage cavity (33) from the open end;wherein the atomization core (2) comprises an atomization sleeve (21) and a heating wire assembly (22), the atomization sleeve (21) is provided with an atomization cavity (211) for receiving the heating wire assembly (22) to atomize e-liquid, and a first e-liquid guide hole (212) allowing the e-liquid in the e-liquid storage cavity (33) to flow into the atomization cavity (211) is defined on a side wall of the atomization sleeve (21); and
wherein the atomization core (2) further comprises an e-liquid inlet control structure (23), the e-liquid inlet control structure (23) is sleeved in the atomization sleeve (21) rotatably or movably in an axial direction of the atomization sleeve (21), openings (233) for mounting the heating wire assembly (22) are arranged on the e-liquid inlet control structure (23), and when the e-liquid inlet control structure (23) is rotated or axially moved, the openings (233) and the first e-liquid guide hole (212) are communicated or completely staggered, so as to open or close the first e-liquid guide hole (212).

US Pat. No. 10,188,140

SMOKING ARTICLE

R.J. Reynolds Tobacco Com...

1. A cigarette comprising:a lighting end and a mouth end;
a mouth end piece segment disposed at the mouth end;
an aerosol-generation system including (i) a heat generation segment disposed at the lighting end, said heat generation segment having a length and including a heat source, and (ii) an aerosol-generating segment incorporating aerosol-forming material, said aerosol-generating segment having a length and being disposed adjacent to, and physically separate from, the heat generation segment, said aerosol-generating segment including a substrate for the aerosol-forming material, the substrate abutting with the heat source in the heat generation segment;
a single piece of a first wrapping material providing an overwrap around at least a portion of the length of the heat generation segment and around at least a portion of the length of the aerosol-generating segment;
a segment incorporating tobacco positioned between the aerosol-generating segment and the mouth end piece segment, such that the first wrapping material does not overwrap the segment incorporating tobacco;
a single piece of a second wrapping material providing an overwrap (i) around the segment incorporating tobacco for the length of that segment, (ii) around the aerosol-generating segment for the length of that segment, and (iii) around the heat generation segment for the majority of the length of that segment; the segment incorporating tobacco, the aerosol-generating segment and the heat generation segment being connected together by the second wrapping material to provide a cigarette rod; and
the mouth end piece segment being connected to the cigarette rod using tipping material.

US Pat. No. 10,188,134

AUTHENTICATED ENCRYPTION SUPPORT IN DASH BASED SEGMENTED STREAMING MEDIA DISTRIBUTION

FUTUREWEI TECHNOLOGIES, I...

3. The server apparatus of claim 1, wherein the MPD comprises a @SegmentEncryption@ivEncryptionFlag attribute and a SegmentEncryption@ivLength attribute, wherein the initialization vector is the segment number when the SegmentEncryption@ivEncryptionFlag value is ‘false’ and the MPD comprises a CryptoPeriod element, wherein the initialization vector is a sum of the segment number and an @ivBase attribute when the SegmentEncryption@ivEncryptionFlag value is ‘false’ and the MPD comprises a CryptoTimeline element, wherein the initialization vector is an Electronic Codebook (ECB)-encrypted value of a transmitted initialization vector when the SegmentEncryption@ivEncryptionFlag value is ‘true’ and the MPD does not comprise a CryptoTimeline element or a CryptoPeriod element, wherein the initialization vector is an ECB-encrypted value of the segment number when the SegmentEncryption@ivEncryptionFlag value is ‘true’ and the MPD comprises a CryptoPeriod element, wherein the initialization vector is an ECB-encrypted value of the sum of the segment number and the @ivBase when the SegmentEncryption@ivEncryptionFlag value is ‘true’ and the MPD comprises a CryptoTimeline element, and wherein the initialization vector is the first SegmentEncryption@ivLength most significant bit from ECB output when the SegmentEncryption@ivEncryptionFlag value is ‘true’ and the SegmentEncryption@ivLength is smaller than the output block size of the ECB output.

US Pat. No. 10,188,127

METHOD FOR PRODUCING FROZEN ICE CREAM PRODUCTS

1. A method for producing frozen ice cream products, using a freezing system comprising a freezing apparatus, said method comprising:placing pre-products to be frozen onto a number of product plates,
conveying pre-products to be frozen into the freezing apparatus,
cooling the pre-products to form frozen products while conveying the pre-products inside the freezing apparatus by exposing them to circulating cold air,
conveying the frozen products out of the freezing apparatus,
measuring one or more surface temperatures of frozen products leaving the freezing apparatus,
using the one or more measured surface temperatures as input for a control device for controlling one or more operational parameters of the freezing apparatus,
lifting the frozen products off the product plates, after conveying them out of the freezing apparatus, by means of a product handling system driven by a driving arrangement, and
measuring one or more torque values exerted by the driving arrangement during the lifting of the frozen products off the product plates, and inputting the one or more measured torque values into a control device for controlling one or more operational parameters of the freezing system.

US Pat. No. 10,188,122

CURD CUTTING METHOD

1. A method of cutting a cheese curd mass within a cylindrical vat, the method comprising:placing a cutting apparatus inside the vat before the cheese curd mass has begun to form;
once the cheese curd mass has formed, horizontally rotating a first knife assembly of the cutting apparatus around a vertical axis, thereby cutting the cheese curd mass into a plurality of horizontal slices; and
thereafter, vertically removing from the vat a second knife assembly of the cutting apparatus, the second knife assembly having knives along at least two distinct orientations of the cutting apparatus, thereby cutting the horizontal slices along said orientations.

US Pat. No. 10,188,121

BACTERIOPHAGE TREATMENT FOR REDUCING AND PREVENTING BACTERIAL CONTAMINATION

Ecolab USA Inc., St. Pau...

1. A method of treating and preventing bacterial contamination in a meat food product, the method comprising:applying a bacteriophage treatment to a packaging material as a foam, the bacteriophage treatment comprising:
at least one bacteriophage in a concentration sufficient to reduce or eliminate bacteria selected from the group consisting of pathogenic bacteria, spoilage bacteria, and combinations thereof;
a buffering agent to maintain the bacteriophage treatment at a pH between approximately 4 and 9;
from about 25 ppm to about 2.0 weight percent of a foaming surfactant selected from the group consisting of alcohol ethoxylates, alcohol ethoxylate carboxylate, amine oxides, alkyl sulfates, alkyl ether sulfate, sulfonates, quaternary ammonium compounds, alkyl sarcosines, betaines, alkyl amides and mixtures thereof; and
an adjuvant comprising one or more of calcium, magnesium, a competitive exclusion bacteria, a fatty acid, a terpene, a terpenoid, glycerol, and propylene glycol, and
packaging the food product in the packaging material.

US Pat. No. 10,188,109

PICOLINAMIDE COMPOUNDS WITH FUNGICIDAL ACTIVITY

Dow AgroSciences LLC, In...

1. A compound of Formula I
wherein
X is hydrogen or C(O)R5;
Y is hydrogen, C(O)R5, or Q;
Q is

R1 and R11 are independently chosen from hydrogen or alkyl, optionally substituted with 0, 1 or multiple R8;
alternatively, R1 and R11 may be taken together to form a 3-6 membered saturated or partially saturated carbocyclic or heterocyclic ring, optionally substituted with 0, 1 or multiple R8;
R2 and R12 are independently chosen from hydrogen, alkyl, aryl, or alkenyl, each optionally substituted with 0, 1 or multiple R8;
R3 is methyl;
R4 is chosen from alkyl, aryl, or acyl, each optionally substituted with 0, 1 or multiple R8;
R5 is chosen from alkoxy or benzyloxy, each optionally substituted with 0, 1, or multiple R8;
R6 is chosen from hydrogen, alkoxy, or halo, each optionally substituted with 0, 1, or multiple R8;
R7 is chosen from hydrogen, —C(O)R9, or —CH2OC(O)R9;
R8 is chosen from hydrogen, alkyl, aryl, acyl, halo, alkenyl, or alkoxy, each optionally substituted with 0, 1, or multiple R10;
R9 is chosen from alkyl, alkoxy, or aryl, each optionally substituted with 0, 1, or multiple R8; and
R10 is chosen from hydrogen, alkyl, aryl, acyl, halo, alkenyl, alkoxy, or heterocyclyl.

US Pat. No. 10,188,105

COMPOSITIONS FOR INHIBITION OF INSECT SENSING

Vanderbilt University, N...

1. A compound, or salt thereof, having a formula:
wherein
R1 is hydrogen, optionally substituted C1-C4 alkyl, optionally substituted phenyl, optionally substituted benzyl, or a structure represented by a formula selected from:

or R1 is taken together with R2 to be optionally substituted (C1-C4) alkanediyl or optionally substituted (C1-C4) alkenediyl; and
R2 is hydrogen,
or R2 is taken together with R1 to be optionally substituted (C1-C4) alkanediyl or optionally substituted (C1-C4) alkenediyl; and
R3 is optionally substituted (C1-C5) alkyl or optionally substituted (C1-C5) alkenyl; and
R4 is optionally substituted and selected from (C1-C5) alkyl and (C1-C5) alkenyl; and
R5 is optionally substituted aryl or optionally substituted (?C6) heteroaryl; and
R6 is hydrogen, optionally substituted (C1-C5) alkyl, or optionally substituted (C1-C5) alkenyl,
wherein the compound is not

US Pat. No. 10,188,104

COMBINATIONS OF LIPO-CHITOOLIGOSACCHARIDES AND METHODS FOR USE IN ENHANCING PLANT GROWTH

1. A method of enhancing plant growth, comprising treating a plant seed with at least two distinct lipo-chitooligosaccharides (LCOs) to synergistically enhance growth of a plant that germinates from said seed, said at least two distinct LCOs comprising:

US Pat. No. 10,188,100

MATRIX COMPOSITION FOR DELIVERY OF HYDROPHOBIC ACTIVES

1. A matrix composition capable of forming an emulsion, a microemulsion, or a dispersion comprising an emulsifiable matrix, consisting of:(i) a dialkyl acid amide having the formula:

wherein,
R1 and R2 are lower alkyl with 1-4 carbon atoms, alicyclic or aromatic;
n1=0-18, n2=0-18, and R?H or CH3; and
(ii) one or more surface active agents, wherein the only surface active agents present are selected from the group consisting of ethoxylated castor oil, ethoxylated/propoxylated block copolymer, ethoxylated phosphate ester, sodium dioctyl sulfosuccinate, and poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol), and wherein at least one of the surface active agents is ethoxylated castor oil.

US Pat. No. 10,188,097

MEDICAL DEVICE INTENDED FOR THE LONG-TERM STORAGE OF A CORNEA, OR FOR EX VIVO EXPERIMENTATION ON A HUMAN OR ANIMAL CORNEA

UNIVERSITE JEAN MONNET, ...

1. A device for storage of a corneal specimen including a cornea and a sclera ciliary zone, comprising:an intermediate component including a first hole having a diameter matching that of the cornea, the first hole surrounded by a circumferential groove and a first edge, the first hole, groove, and first edge forming a cavity to receive the corneal specimen, the cavity configured to ensure that the corneal specimen is centered when inserted into the device and configured to stabilize the corneal specimen when the device is opened at an operating theater;
an endothelial lid including a second hole having a diameter matching that of the cornea, the second hole surrounded by a second edge configured to trap the corneal specimen by flattening the sclera ciliary zone on the circumferential groove of the intermediate component; and
an epithelial lid;
wherein the intermediate component and the endothelial lid are configured to entrap the sclera ciliary zone in an airtight manner to delimit an endothelial chamber and an epithelial chamber separate from the endothelial chamber;
wherein the endothelial chamber is composed of a space formed between the endothelial lid and the intermediate component after a tight connection of the endothelial lid to the intermediate component;
wherein the epithelial chamber is composed of a space formed between the intermediate component and the epithelial lid after a tight connection of the epithelial lid to the intermediate component;
wherein the intermediate component and the endothelial lid each comprise a respective inlet orifice and a respective outlet orifice, the orifices allowing a preservation medium to circulate through the endothelial chamber and through the epithelial chamber;
the inlet orifice of the endothelial lid being connected to a preservation medium reservoir containing the preservation medium, such that during use the preservation medium contained in the preservation medium reservoir flows into the endothelial chamber from the preservation medium reservoir;
the outlet orifice of the endothelial lid being connected to the inlet orifice of the intermediate component, such that during use the preservation medium contained in the endothelial chamber flows into the epithelial chamber from the endothelial chamber,
the outlet orifice of the intermediate component being connected to a waste reservoir, such that during use the preservation medium contained in the epithelial chamber flows into the waste reservoir from the epithelial chamber,
the connections of the orifices allowing the preservation medium to circulate on both sides of the cornea, firstly in the endothelial chamber and secondly in the epithelial chamber, and allowing the creation of a pressure gradient between the endothelial chamber and the epithelial chamber with overpressure in the endothelial chamber.

US Pat. No. 10,188,096

DEVICE FOR GRIPPING AND REMOVING A BAIT STATION

1. A gripping device for removing a bait station from a ground soil, the bait station having an opening with a dimension, the opening leading to an internal surface with at least two opposing portals on the internal surface, the gripping device comprising:a) a frame comprising a back end piece and a front end piece spaced from each other by connecting sides, wherein the connecting sides define a bottom portion with a handgrip to conform to fingers of a user;
b) a plunger slidably mounted in an opening in the front end piece;
c) a spring connected between the back end piece and plunger for biasing the plunger toward a second extended gripping position from a first retracted position;
d) a first hook fixedly attached to the frame; and
e) a second hook attached to the plunger for movement between the first retracted position and the second extended gripping position,
wherein the first hook and the second hook fit within the dimension of the opening of the bait station when the plunger is in the first retracted position and wherein the first hook and the second hook engage the two opposing portals when the plunger is in the second extended gripping position; and
wherein the plunger has a thumb piece opposite the engagement of the spring with the plunger and wherein the front end piece includes a thumb cover that has a bottom, two sides, and an open top to allow a user's thumb to engage the thumb piece.

US Pat. No. 10,188,095

TREE STAND

1. A tree stand comprising a seating member having:first and second side members, the side members extending substantially parallel with each other with a bend in each of the first and second side members, the first and second side members each having a first end and a second end opposite the first end;
a removable tree attachment member, the removable tree attachment member being a linear member running substantially orthogonal to the first and second side members, spanning from the first side member to the second side member proximate to the first end of the first and second side members;
a fixed tree attachment member, the fixed tree attachment member running substantially orthogonal to the first and second side members, spanning from the first side member to the second side member at a location between the bend and the first end of each of the first and second side members;
first and second angled tree attachment members, the first and second angled tree attachment members interconnecting the fixed tree attachment member with each of the first and second side members, the first and second angled tree attachment members forming an angle with the fixed tree attachment member from about 30 degrees to about 60 degrees;
a fixed seat defining member, the fixed seat defining member running substantially orthogonal to the first and second side members, spanning from the first side member to the second side member proximate to the second end of the first and second side members; and
a seat attached to the side members via a plurality of seat straps, each of the seat straps disposed as loops about the side members, the loops disposed between the fixed tree attachment member and the fixed seat defining member.

US Pat. No. 10,188,093

ACTIVE ELECTROSTATIC WILDLIFE GUARD FOR ELECTRICAL POWER DISTRIBUTION EQUIPMENT

TE Connectivity Corporati...

1. An apparatus for wildlife deterrence on a high voltage conductor, the apparatus comprising:an electrical insulator including an electrically insulating material without a conductive material, the electrical insulator comprising:
a first surface;
a second surface that is opposite the first surface;
a first edge that is between the first surface and the second surface, the first edge and the first and second surfaces defining outer edges of the first and second surfaces, respectively; and
a second edge that is opposite the first edge and that is between the first surface and the second surface, the second edge and the first and second surfaces defining interior edges of the first and second surfaces, respectively;
a third edge that is between a proximal end of the first edge and a proximal end of the second edge and that is between the first surface and the second surface;
a fourth edge that is between a distal end of the first edge and a distal end of the second edge and that is between the first surface and the second surface;
a central opening defined in the electrical insulator including through the first and second surfaces; and
a gap defined by the third edge and the fourth edge that communicates with the central opening;
an electrical conductor that is arranged on the first surface of the electrical insulator and is spaced apart from each of the first edge and the second edge, wherein the electrical conductor extends continuously from the third edge to the fourth edge.

US Pat. No. 10,188,092

BREAKAWAY ADAPTER SYSTEM FACILITATING BOTH FRONT-MOUNTED AND REAR-MOUNTED CONFIGURATIONS OF A SPRAYER BOOM

CNH Industrial America LL...

1. A breakaway adapter system facilitating both front-mounted and rear-mounted configurations of a sprayer boom of an agricultural sprayer, wherein the sprayer boom includes a main boom body connected to the agricultural sprayer with the main boom body having outer ends, a sprayer facing side facing toward the sprayer, and an outwardly facing side facing away from the sprayer, wherein the breakaway adapter system comprises:a pair of breakaway boom segments arranged outwardly beyond outer ends of the main boom body;
a pair of breakaway joints arranged between the outer ends of the main boom body and the pair of breakaway boom segments, wherein the breakaway joints are configured to allow the breakaway boom segments to deflect in rearward deflection directions; and
a pair of adapter arrangements between the outer ends of the main boom body and the pair of breakaway joints, each adapter arrangement configured to engage and support either breakaway joint of the pair of breakaway joints;
wherein when the sprayer boom is in the front-mounted configuration, the breakaway joints mount to the adapter arrangements in a first mounting position in which the breakaway joints are arranged to allow the breakaway boom segments to deflect in a deflection direction that is common with a direction faced by the sprayer facing side of the main boom body; and
wherein when the sprayer boom is in the rear-mounted configuration, the breakaway joints mount to the adapter arrangements in a second mounting position in which the breakaway joints are arranged to allow the breakaway boom segments to deflect in a deflection direction that is common with a direction faced by the outwardly facing side of the main boom body.

US Pat. No. 10,188,090

FISH RECEPTACLE

1. A fish receptacle, comprising:a container having a base, one or more upstanding sidewalls, an open upper end, defining an interior volume, the container configured to store water and fish therein;
a lid pivotally connected to the upper end of the container, the lid providing access to the interior volume of the container;
a door assembly disposed on the lid, the door assembly comprising a frame disposed around a perimeter of an aperture disposed through the lid;
wherein the frame is affixed to an upper surface of the lid about the aperture, wherein a front wall, a rear wall, a left wall, and a right wall each extend perpendicularly away from the frame;
a track disposed within the frame, wherein the track comprises two opposing rails disposed within each of the left and right walls of the frame and a slot through the rear wall of the frame;
wherein the door assembly further comprises a sliding member configured for sliding engagement with the track;
wherein the sliding member is movable between an open position to expose the aperture of the door assembly and a closed position to at least partially cover the aperture.

US Pat. No. 10,188,089

DEVICE FOR REMOVING A FISH FROM A LINE

1. A fish removing device, comprising:a first end bending back into a U shaped end configured to engage a fishing line;
the U shaped end extending into a straight section; and
a gripping section connected to the straight section.

US Pat. No. 10,188,079

STRAP FOR ATTACHING A DECORATIVE ORNAMENT TO THE HEAD OF A PET

1. A strap assembly for securing a decorative ornament to a head of an animal, comprising:a chin strap comprising a continuous loop;
a first ear strap for placement around a back of a first ear of the animal;
a second ear strap for placement around a back of a second ear of the animal; and
an ornament attachment device permitting an ornament to be removably attached thereto;
wherein the first ear strap and the second ear strap can be joined together permitting the joined-together ear straps to wrap under the neck of the animal;
wherein the first ear strap and the second ear strap are portions of a single, continuous elongated strip when joined together;
wherein the chin strap is attached to the continuous elongated strip;
wherein the ornament attachment device is attached to the chin strap and the continuous elongated strip at the point where the chin strap and the continuous elongated strip are attached together.

US Pat. No. 10,188,050

VOLUMETRIC BUDGET BASED IRRIGATION CONTROL

Rain Bird Corporation, A...

1. A method of controlling irrigation, the method comprising:receiving water usage information corresponding to a first volumetric water usage at a site location having an irrigation controller configured to implement and control irrigation at the site and comprising valve drivers each configured to activate one or more valves distributed through the site location and an irrigation controller processor configured to implement an irrigation schedule stored in local memory of the irrigation controller, wherein the first volumetric water usage corresponds to volumetric water usage from a beginning of a budget period of time to a first time within the budget period of time;
determining automatically whether a volumetric water budget at the site location will be met for the budget period of time based on at least the first volumetric water usage, the volumetric water budget corresponding to a specified volume of water for use during the budget period of time;
determining automatically, in the event the volumetric water budget will not be met, an adjustment to the irrigation by the irrigation controller, wherein the adjustment comprises a reduction of runtimes of remaining irrigation events scheduled to occur during the budget period of time such that the adjustment substantially spreads a compensation for an amount of water usage that will exceed the volumetric water budget over the remaining irrigation events; and
outputting signaling causing the irrigation controller to control the valve drivers of the irrigation controller to control opening and closing of one or more of the valves at the site location coupled with the irrigation controller in controlling water released through water delivery devices fluidly coupled with a corresponding one of the valves in controlling irrigation at the irrigation site to effect the adjustment.

US Pat. No. 10,188,047

PLANT LABELING SYSTEM AND GARDEN TOOLS

1. A modular display system, comprising:a seed storage hutch;
a vertical display stand supporting the seed storage hutch;
at least one pigtail attached to the stand and configured to support at least one growing pot, hook or shelf above the ground, wherein the at least one pigtail is attached to the stand and may be swiveled, positioned vertically along the stand or removed entirely; and
a base configured to receive and support the display stand in a substantially vertical orientation.

US Pat. No. 10,188,044

TREE-TRIMMING DEVICE

1. A horticultural tool comprising:a reciprocating shaft, an extension guard and an extensible structure;
wherein the horticultural tool is configured to use with a reciprocating saw;
wherein the reciprocating saw further comprises a reciprocating structure;
wherein the horticultural tool is a bladed device that is adapted for use in cutting a plant;
wherein the horticultural tool is configured to extend the reach of the reciprocating saw;
wherein the reciprocating shaft is configured to connect the extensible structure to the reciprocating saw;
wherein the extensible structure is inserted through the extension guard;
wherein the reciprocating shaft is attached to the reciprocating structure of the reciprocating saw;
wherein the reciprocating shaft includes a spring-loaded button that is used to secure a linking shaft to the reciprocating saw;
wherein the spring-loaded button is biased outwardly via a spring;
wherein the spring-loaded button of the reciprocating shaft interfaces with a button-hole provided on the linking shaft;
wherein the extension guard comprises a guard, a support, and a foot;
wherein the guard is formed in the shape of a frustum of a pyramid wherein the base of the pyramid is attached to the reciprocating saw;
wherein the support is a square structure that forms a frustum surface that is proximal to the apex of the pyramid;
wherein the foot is a structure that attaches to the support such that the foot projects away from the support in a direction away from the reciprocating saw;
wherein the guard comprises a frame;
wherein the frame is the structural framework that forms the pyramidal shape of the guard;
wherein the frame is formed from a plurality of metal shafts;
wherein the support comprises a plurality of rollers, and a plurality of corners;
wherein the support is a square shaped structure;
wherein each of the plurality of corners is a piece of metal;
wherein each of the plurality of corners is used to form a corner of the square shaped structure;
wherein any first corner selected from the plurality of corners is attached to a second corner selected from the plurality of corners by a roller selected from the plurality of rollers.

US Pat. No. 10,188,032

MOWER WITH MOTOR COOLING

KUBOTA CORPORATION, Osak...

1. A ride-on mower comprising:an operator seat;
drive wheels;
steerable wheels;
at least one rotationally driven grass cutting blade;
at least one motor configured to cause rotation of the grass cutting blade;
said at least one motor comprising a motor housing having an axial length that is shorter than half a cross-sectional diameter or width;
a mower deck compromising a blade rotation space defined by an upper surface and a downward extending sidewall, said mower deck housing the grass cutting blade in an interior thereof;
at least one guide member defining an air flow passage along the motor housing, the air flow passage connecting the interior and exterior of the mower deck; and
said at least one guide member being a separately formed member that is mounted to the mower deck and said at least one guide member having an axial length that is shorter than a diameter or cross-sectional width of said at least one guide member,
wherein the guide member guides a cooling air flow that flows outside of the motor housing, said cooling air flow entering from above the guide member, passing downwards axially between the guide member and the motor housing, and then, inside the mower deck, passing radially inwards towards a motor shaft, and
wherein the cooling flow passing radially inwards towards the motor shaft occurs below the upper surface and inside the blade rotation space.

US Pat. No. 10,188,027

ROW UNIT WITH SHANK OPENER

Kinze Manufacturing, Inc....

1. A row unit for use with an agricultural implement, comprising:a frame;
a winged shank opener operatively connected to the frame and comprising:
a rear portion;
a front portion that is narrower than the rear portion; and
first and second wings on opposite sides of the winged shank to aid in pulling the winged shank into a field, said wings being angled from the front portion to the rear portion; and
a ski member operatively connected to the frame such that at least a portion of the winged shank extends below the ski member to form a furrow and the ski member at least partially controls the depth of said furrow, wherein said ski member comprises:
a front section having an angled protrusion for initially breaking up soil in the field as the row unit travels in a forward direction; and
a rear section having a gap such that part of the winged shank passes through the gap to displace broken up soil away from the ski member and the winged shank.

US Pat. No. 10,188,022

ROTATING LIFT SYSTEM AND METHOD

Bestway, Inc., Hiawatha,...

1. A system for placing a load on a vehicle including a vehicle frame, which load-placing system comprises:a load lift assembly having a first, lowered position for connecting to a load, a second, raised position with said load lifted above a level of said vehicle frame, and a third, transport position with said load positioned over and connected to said vehicle frame;
a lift actuator connected to said load lift assembly and configured for moving said load lift assembly between its lowered and raised positions;
a transfer actuator connected to said load lift assembly and configured for moving said load lift assembly between its raised and transport positions axially along said vehicle frame;
said load lift assembly including a lower linkage assembly including a pair of lift arms configured for connecting to two points of said three-point hitch;
said load lift assembly including a top link configured for connecting to a third point of said three-point hitch;
said top link being pivotally pinned to a pair of mounting brackets affixed to said load lift assembly;
a hydraulic reservoir assembly configured to operate said lift actuator and said transfer actuator;
a motor assembly configured to provide power to said hydraulic reservoir assembly;
a control assembly configured to send control signals to said hydraulic reservoir assembly;
a first hydraulic arm connected to a front end of said vehicle frame, said hydraulic arm configured for moving said load lift assembly between said second, raised position in proximity to a rear end of said vehicle frame and said third, transport position in proximity to said front end of said vehicle frame; and
a second hydraulic arm configured to pivot said lower linkage assembly about said lift arm weldment.
US Pat. No. 10,188,131

HYDROCOLLOIDS COPROCESSED WITH CELLULOSIC FIBERS WHEN BEING SHEARED INTO HIGHLY REFINED CELLULOSE

1. A method for refining cellulosic material from parenchymal fiber mass comprising:soaking raw non-refined material from organic fiber plant mass comprising at least 50% by weight of all fiber mass as the parenchymal fiber mass in an aqueous solution with less than 1% NaOH;
draining the raw non-refined material and allowing the raw material to sit for sufficient time to enable cells in the raw non-refined material to form open cells and expand the raw material into an expanded fiber product, the soaking producing soaked raw materials with open cells;
refining the soaked raw material to produce refined material by shearing the soaked raw materials in the presence of at least 10% by weight of hydrocolloid with respect to the weight of the organic fiber plant mass; and
then drying the sheared mixture of highly refined cellulosic fiber and hydrocolloid.
US Pat. No. 10,190,186

METHOD FOR MANUFACTURING A HIGH-STRENGTH GALVANIZED STEEL SHEET HAVING EXCELLENT FORMABILITY AND CRASHWORTHINESS

JFE Steel Corporation, T...

1. A method for manufacturing a high-strength galvanized steel sheet having excellent formability and crashworthiness, the method comprising:hot-rolling a steel slab having a composition containing, by mass %, C: 0.05% or more and 0.5% or less, Si: 0.01% or more and 2.5% or less, Mn: 0.5% or more and 3.5% or less, P: 0.003% or more and 0.100% or less, S: 0.02% or less, Al: 0.010% or more and 0.5% or less, B: 0.0002% or more and 0.005% or less, Ti: 0.05% or less, a relationship of Ti>4N being satisfied, and the balance comprising Fe and inevitable impurities at a finish rolling temperature of an A3 transformation point or higher;
after the completion of finish rolling, subsequently cooling the resulting steel sheet to a coiling temperature at an average cooling rate of 30° C./s or more;
coiling the steel sheet at the coiling temperature of 300° C. or higher and 550° C. or lower to form a hot-rolled steel sheet;
then performing heat treatment on the hot-rolled steel sheet, the heat treatment including heating the hot-rolled steel sheet to an annealing temperature of (A3 transformation point ?20° C.) or higher and (A3 transformation point +80° C.) or lower at an average heating rate of 5° C./s or more in a temperature range of 500° C. or higher and an A1 transformation point or lower, holding the steel sheet at the annealing temperature for 10 seconds or more, then cooling the steel sheet from 750° C. to a temperature range of 100° C. or higher and 350° C. or lower at an average cooling rate of 30° C./s or more, subsequently reheating the steel sheet to a temperature of 300° C. or higher and 600° C. or lower, and holding the steel sheet at the temperature for 10 seconds or more and 600 seconds or less;
then galvanizing the steel sheet, and optionally performing an alloying treatment, such that the high-strength galvanized steel sheet is formed having a microstructure containing 64% or more and 95% or less of tempered martensite in terms of area ratio and 5% or more and 20% or less of retained austenite in terms of area ratio, the tempered martensite having an average grain diameter of 5 ?m or less.
US Pat. No. 10,189,932

THERMOPLASTIC MOLDING COMPOUNDS WITH AN OPTIMIZED RESIDUAL MONOMER CONTENT

INEOS STYROLUTION GROUP G...

1. A process for the production of styrene graft copolymers comprising the following steps:(i) provision and agglomeration of the graft base B present in an emulsion;
(ii) addition of styrene monomers A1 and vinyl cyanide monomers A2 to the graft base B over a defined monomer feed time; and
(iii) simultaneous graft copolymerization of the added styrene monomers A1 and of the vinyl cyanide monomers A2 onto the agglomerated graft base B,
where, in step (ii), the ratio by mass of styrene monomers A1 to vinyl cyanide monomers A2 in the monomer feed at the end of the monomer feed time is lower than the ratio by mass of the components of the monomer feed integrated over the entire monomer feed time,
where step (iii) is followed by the following step (iv), which comprises:
(iv) addition of vinyl cyanide monomers A2 and graft copolymerization of these onto the agglomerated graft base B, where no styrene monomers A1 are added.
US Pat. No. 10,188,908

POLYAMIDE COMPOSITIONS CONTAINING PLASTICIZERS FOR USE IN MAKING GOLF BALLS

Acushnet Company, Fairha...

1. A golf ball, comprising:a) a core comprising an inner core and outer core layer, the inner core having an outer surface and geometric center and the outer core layer having an outer surface and inner surface; the inner core comprising a polyamide composition and the outer core layer comprising a rubber composition the polyamide composition comprising:
i) about 40 to about 90% by weight polyamide; and
ii) about 10 to about 60% by weight of a plasticizer selected from the group consisting of ethyl oleate and propylene carbonate and blends thereof, the polyamide comprising a blend of transparent and non-transparent polyamides, wherein at least one of the transparent polyamides is a polyether-amide block copolymer, and wherein the center of the inner core and surface of the outer core layer each has a hardness, and the surface hardness of the outer core layer is greater than the center hardness of the inner core; and
b) a cover having at least one layer disposed about the core.
US Pat. No. 10,188,654

USES OF PYRIMIDO-PYRIDAZINONES TO TREAT CANCER

Asana BioSciences, LLC, ...

1. A method of treating a cancer subject, comprising administering to a cancer subject in need thereof, a therapeutically effective amount of a compound 2-(1-(4-((4-(4-hydroxypiperidin-1-yl)phenyl)amino)-5-oxo-5,6-dihydropyrimido[4,5-d]pyridazin-2-yl)piperidin-4-yl)acetonitrile, or a pharmaceutically acceptable salt or ester thereof, wherein:the cancer subject has a recurrent or refractory cancer;
the cancer is a hematopoietic cancer; and
the cancer is refractory to Ibrutinib.
US Pat. No. 10,189,936

BLOCK COPOLYMER, DISPERSANT, AND PIGMENT DISPERSION COMPOSITION

OTSUKA CHEMICAL CO., LTD....

1. A block copolymer of an ABA type including an A block and a B block and having an acid value of 30 to 250 mgKOH/g, the B block containing a structural unit derived from a vinyl monomer with an acid group, wherein a structural unit derived from a vinyl monomer with an acid group and contained in the A block is at a content of 10% by mass or less in 100% by mass of the A block.
US Pat. No. 10,189,937

FINE POWDER-COATED AMINE AND COMPOSITION CONTAINING SAME

SUNSTAR ENGINEERING INC.,...

1. A fine powder-coated amine comprising a solid amine having a melting point equal to or higher than 50° C. and a mean particle size equal to or smaller than 20 ?m, wherein the fine powder-coated amine has an amount of heat in the second absorption peak measured by a differential scanning calorimeter equal to or less than 220 J/g, and the surface of the solid amine is coated with fine particles having a mean particle size equal to or smaller than 2 ?m.
US Pat. No. 10,190,194

COPPER ALLOY FOR ELECTRONIC AND ELECTRICAL EQUIPMENT, COPPER ALLOY THIN SHEET FOR ELECTRONIC AND ELECTRICAL EQUIPMENT, AND CONDUCTIVE COMPONENT FOR ELECTRONIC AND ELECTRICAL EQUIPMENT, TERMINAL

MITSUBISHI MATERIALS CORP...

1. A copper alloy for electronic and electrical equipment, comprising:more than 2.0 mass % to 36.5 mass % of Zn;
0.10 mass % to 0.90 mass % of Sn;
0.15 mass % to less than 1.00 mass % of Ni;
0.005 mass % to 0.100 mass % of P; and
a balance containing Cu and inevitable impurities,
wherein an atomic ratio Ni/P of an amount of Ni to an amount of P satisfies a relationship of 3.00 an atomic ratio Sn/Ni of an amount of Sn to an amount of Ni satisfies a relationship of 0.10 a strength ratio TSTD/TSLD is 1.10 or more, where strength TSTD is obtained when a tensile test is performed in a direction perpendicular to a rolling direction and strength TSLD is obtained when another tensile test is performed in a direction parallel to the rolling direction.
US Pat. No. 10,188,657

COMPOSITIONS AND METHODS FOR PROPHYLAXIS AND THERAPY FOR MENIERE'S DISEASE

1. A method comprising administering to an individual diagnosed with Meniere's Disease a pharmaceutical composition comprising an effective amount of lamotrigine or a pharmaceutically acceptable salt thereof such that the effective amount of the lamotrigine or the pharmaceutically acceptable salt thereof is sufficient to reduce dizziness that is caused by the Meniere's Disease in the individual, and wherein the lamotrigine or the pharmaceutically acceptable salt thereof is the only bioactive compound in the pharmaceutical composition that is effective to treat the dizziness caused by the Meniere's Disease.
US Pat. No. 10,189,941

POLYCARBONATE COMPOSITIONS CONTAINING POLYETHYLENE WAX

Covestro Deutschland AG, ...

1. A polycarbonate composition comprisingA) polycarbonate
B) oxidized acid-modified polyethylene wax and
D) an inorganic filler,
wherein the oxidized acid-modified polyethylene wax has an acid number of <10 mg KOH/g determined according to JIS K0070, a crystallinity of greater than 60% and less than 90%, a melting point between 90° C. and 130° C. and a viscosity average molar mass determined by viscometry between 1500 g/mol and 5000 g/mol.
US Pat. No. 10,188,660

ANTI-HULRRC15 ANTIBODY DRUG CONJUGATES AND METHODS FOR THEIR USE

AbbVie Inc., North Chica...

1. An anti-huLRRC15 antibody drug conjugate (ADC) comprising an antimitotic agent linked to an anti-huLRRC15 antibody by way of a linker, wherein the ADC has a structure of formula (I):[D-L-XY]n-Ab  (I)
or a salt thereof, wherein:
D is the antimitotic agent;
L is the linker;
Ab is the anti-huLRRC15 antibody;
XY represents a covalent linkage linking linker L to antibody Ab; and
n is an integer ranging from 2 to 8;
wherein
Ab comprises
a VH chain comprising the sequence of SEQ ID NO:16 and a VL chain comprising the sequence of SEQ ID NO:17,
a VH chain comprising the sequence of SEQ ID NO:26 and a VL chain comprising the sequence of SEQ ID NO:27,
a VH chain comprising the sequence of SEQ ID NO:36 and a VL chain comprising the sequence of SEQ ID NO:37,
a VH chain comprising the sequence of SEQ ID NO:46 and a VL chain comprising the sequence of SEQ ID NO:47,
a VH chain comprising the sequence of SEQ ID NO:56 and a VL chain comprising the sequence of SEQ ID NO:57,
a VH chain comprising the sequence of SEQ ID NO:66 and a VL chain comprising the sequence of SEQ ID NO:67, or
a VH chain comprising the sequence of SEQ ID NO:76 and a VL chain comprising the sequence of SEQ ID NO:77.
US Pat. No. 10,190,198

THICK FILM PASTE AND USE THEREOF

E I DU PONT DE NEMOURS AN...

1. A thick film paste composition comprising:(a) inorganic constituents that consist of:
a platinum source that is at least one of a particulate platinum (alloy) or a particulate platinum (alloy)/metal oxide composite, and
at least one metal compound selected from the group consisting of particulate metal oxides and precursor compounds capable of forming a metal oxide on firing, the metal oxide in each case being selected from the group consisting of NiO, SiO2, RuO2, Rh2O3, IrO2, Cu2O, CuO, TiO2, ZrO2, PbO, SnO2, CeO2, Al2O3, MgO, and MnO2; and
(b) an organic vehicle,
and wherein:
the proportion of the at least one metal compound is 0.001 to 1 wt. %, based on the total thick film paste composition; and
the thick film paste composition is capable of being fired to form an electrically conductive metallization that is electrically connected with an electrode on a ceramic sensor substrate.
US Pat. No. 10,189,943

COPOLYMERS SUITABLE FOR MAKING MEMBRANES

BASF SE, Ludwigshafen (D...

1. A copolymer, comprising polyarylene ether blocks and hydrophilic-hydrophobic blocks,wherein:
said hydrophilic-hydrophobic blocks comprise polyisobutene blocks; and
said hydrophilic-hydrophobic blocks comprise polyisobutene blocks with terminal phenolic ether groups, and said phenolic ether groups are etherified with polyalkyleneoxides.
US Pat. No. 10,189,945

METHOD FOR PRODUCING LIGHT-COLOURED TDI-POLYISOCYANATES

Covestro Deutschland AG, ...

1. A method for producing polyisocyanates comprising urethane groups and having APHA colour indices <50 Hazen comprising reacting di- to tetra-valent organic polyhydroxy compounds with excess amounts of toluylene diisocyanate and then removing unreacted excess toluylene diisocyanate to residual contents <0.5 wt. % by distillation, wherein the toluylene diisocyanate has a content of 2-chloro-6-isocyanato-methylcyclohexadienes <5 wt·ppm.
US Pat. No. 10,188,667

PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE OF 4-PREGENEN-11?-17-21-TRIOL-3,20-DIONE DERIVATIVES

ALLERGAN, INC., Irvine, ...

1. A method of treating an ocular condition associated with glucocorticoid and or mineralocorticoid receptor modulation which comprises topically administering to a patient in need thereof, a pharmaceutical composition comprising a therapeutically effective amount of at least one compound selected from:(8S,9S,10R,11S,13S,14S,17R)-17-glycoloyl-11-hydroxy-10,13 -dimethyl-3 -oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl phenylacetate;
(8S,9S,10R,11S,13S,14S,17R)-17-glycoloyl-11-hydroxy-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl butyrate;
(8S,9S,10R,11S,13S,14S,17R)-17-glycoloyl-11-hydroxy-10,13 -dimethyl-3 -oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl propionate;
(8S,9S,10R,11S,13S,14S,17R)-17-glycoloyl-11-hydroxy-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl octanoate;
(8S,9S,10R,11S,13S,14S,17R)-17-Glycoloyl-11-hydroxy-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl hexanoate;
(8S,9S,10R,11S,13S,14S,17R)-17-glycoloyl-11-hydroxy-10,13 -dimethyl-3 -oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl benzoate;
(8S,9S,10R,11S,13S,14S,17R)-17-glycoloyl-11-hydroxy-10,13 -dimethyl-3 -oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl heptanoate;
(8S,9S,10R,11S,13S,14S,17R)-17-glycoloyl-11-hydroxy-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl 2-methylpropanoate; and
(8S,9S,10R,11S,13S,14S,17R)-17-glycoloyl-11-hydroxy-10,13 -dimethyl-3 -oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl cyclopentanecarboxylate,
and further comprising carboxymethylcellulose, sodium phosphate, citrate buffer, and sodium chloride,
and having a pH from about 4.5 to 7.5.
US Pat. No. 10,189,952

DEGRADABLE THIOL-ENE POLYMERS

REGENTS OF THE UNIVERSITY...

21. A method for producing a biocompatible thiol-ene hydrogel, the method comprisingsubjecting a polymerization reaction mixture comprising at least one thiol compound and at least one olefin compound to a radical polymerization reaction under conditions sufficient to produce the biocompatible thiol-ene hydrogel, wherein:
(a) the at least one thiol compound comprises m number of reactive thiol groups;
(b) the at least one olefin compound comprises n number of reactive ene groups; and
(c) each of n and m is an integer of at least 2, provided the sum of n+m is at least 5.
US Pat. No. 10,190,219

ELECTRICAL STEEL SHEET

1. An electrical steel sheet, comprising:a base material of electrical steel; and
an insulating film formed on a surface of the base material,
wherein the insulating film contains a phosphate of one or more selected from the group consisting of Al, Zn, Mg and Ca,
wherein a proportion of an amount by mole (mol) of Fe atoms relative to an amount by mole (mol) of P atoms in the insulating film is not less than 0.30 and not more than 0.65, and
a limit sodium chloride concentration is 0.1 mass % or more,
wherein the limit sodium chloride concentration represents a maximum concentration of the sodium chloride solution with which the electrical steel sheet does not rust when 0.5 ?L liquid droplets of sodium chloride solutions different in concentration are deposited on the surface of the electrical steel sheet having the insulating film and dried, and the electrical steel sheet is held in an atmosphere with constant temperature and humidity of a temperature of 50° C. and a relative humidity of 90% for 48 hours.
US Pat. No. 10,190,226

REACTION PRODUCTS OF HETEROCYCLIC NITROGEN COMPOUNDS POLYEPOXIDES AND POLYHALOGENS

Rohm and Haas Electronic ...

1. A compound comprising a reaction product of one or more heterocyclic nitrogen compounds comprising at least two reactive nitrogen atoms with the proviso that at least one of the reactive nitrogen atoms is in the ring of the one or more heterocyclic nitrogen compounds; one or more polyepoxide compounds and one or more polyhalogen compounds, wherein the one or more polyhalogen compounds have a formula:X1—R13—X2  (VII)wherein X1 and X2 may be the same or different and are halogens chosen from chlorine, bromine, fluorine and iodine, R13 is linear or branched, substituted or unsubstituted (C1-C20)alkyl, or is a moiety having formula:—C(HR14)—R15—C(HR14)—  (VIII)wherein each R14 is independently selected from hydrogen, halogens chosen from chlorine, bromine, fluorine and iodine, linear or branched, substituted or unsubstituted (C1-C18)alkyl, substituted or unsubstituted (C6-C12)cycloalkyl, substituted or unsubstituted (C6-C15)aryl; R15 is linear or branched, substituted or unsubstituted (C1-C18)alkyl, substituted or unsubstituted (C6-C12)cycloalkyl, substituted or unsubstituted (C6-C15)aryl, —CH2—O—(R16—O)d—CH2— where R16 is a substituted or unsubstituted, linear or branched (C2-C10)alkyl and d is an integer of 1-10.
US Pat. No. 10,189,716

ZEOLITE MONOLITH AND METHOD OF MAKING THE SAME, COMPOSITE WITH ZEOLITE MONOLITH AND METHOD OF MAKING THE SAME, AND METHOD FOR INCORPORATING TWO OR MORE ZEOLITE MONOLITHS

1. A method of manufacturing a porous monolithic zeolite structure including the steps of:(a) taking a porous monolithic substrate;
(b) forming one or more zeolites on the substrate; and
(c) substantially or completely removing said substrate.
US Pat. No. 10,189,976

CURABLE COMPOSITION COMPRISING AN ETHYLENE POLYMER, A MONOPEROXYCARBONATE AND A T-ALKYL HYDROPEROXIDE

ARKEMA FRANCE, Colombes ...

1. A curable composition comprising:(a) at least one ethylene polymer,
(b) at least one monoperoxycarbonate, and
(c) from 0.05 to less than 0.4 part by weight of at least one t-alkyl hydroperoxide for 100 parts by weight of constituent (b).
US Pat. No. 10,189,979

NUCLEATED PHTHALATE-FREE PP HOMOPOLYMERS FOR MELT-BLOWN FIBERS

BOREALIS AG, Vienna (AT)...

1. A polypropylene composition suitable for the production of meltblown PP fibers comprising:(A) a propylene homopolymer, produced with a Ziegler-Natta catalyst (ZN-C), and
(B) a polymeric nucleating agent,
wherein the polypropylene composition has
i) a melt flow rate MFR2 (230° C./2.16 kg) measured according to ISO 1133 of 90 to 5000 g/10 min, and
ii) a difference between melting temperature (Tm) and crystallization temperature (Tc), (Tm?Tc) of <45° C., and
wherein the propylene homopolymer has been visbroken and has an MFR2 of 400 to 3000 g/10 min.
US Pat. No. 10,188,698

SAPOSIN C-DOPS: A NOVEL ANTI-TUMOR AGENT

1. A method for decreasing tumor volume in a subject comprising the step of administering to the subject a composition comprisinga phospholipid, wherein the phospholipid is phosphatidylserine;
an isolated saposin C-related polypeptide, wherein the polypeptide has an amino acid sequence at least 85 percent identical to SEQ ID NO: 2 and wherein the polypeptide includes amino acids 24-40 of SEQ ID NO:2; and
wherein the phospholipid forms a nanovesicle incorporating the polypeptide.
US Pat. No. 10,188,702

METHODS AND COMPOSITIONS FOR TREATING HYPOGLYCEMIC DISORDERS

THE TRUSTEES OF THE UNIVE...

1. A method of treating congenital hyperinsulinism in a subject having congenital hyperinsulinism comprising administering to the subject an effective amount of a peptide wherein the amino acid sequence of the peptide consists of the amino acid sequence set forth in SEQ ID NO: 1.
US Pat. No. 10,188,704

ENHANCED MELANOMA CANCER PREVENTION BY NOVEL MELANOTROPINS

ARIZONA BOARD OF REGENTS ...

wherein Waa is a Met, Ile, or Leu, Xaa is a His or Pro, Yaa is an Arg or Leu, and Zaa is a Phe or Trp, and wherein R1 of the C-terminal is —NH2, or —OH, with the caveat that Waa is not Met, Xaa is not His, Yaa is not Arg, Zaa is not Trp, and R1 is not OH simultaneously.
US Pat. No. 10,189,217

METHOD FOR PREPARING THERMOPLASTIC PREPREG AND THERMOPLASTIC PREPREG PREPARED THEREBY

KOLON INDUSTRIES, INC., ...

1. A method for preparing a thermoplastic prepreg, comprising:laminating a thermoplastic resin film having a crystallization degree in a range of 1 to 20% on at least one surface of a matrix fiber to give a laminate; and
heating the laminate to a higher temperature than a melting point of the thermoplastic resin film, then, pressing the heated laminate,
wherein the thermoplastic prepreg has a weight variation per unit area of 3-5%,
said weight variation per unit area being determined by the following equation (I) or (II):
weight variation per unit area (%)=[(W0?W1)/W0]×100  (I)
weight variation per unit area (%)=[(W1?W0)/W0]×100  (II)
wherein W0 is an average weight of 10 samples of the thermoplastic prepreg, and
W1 is a weight of the samples which show the greatest difference from the average weight W0.
US Pat. No. 10,188,707

ENOLASE 1 (ENO1) COMPOSITIONS AND USES THEREOF

Berg, LLC, Framingham, M...

1. A pharmaceutical composition comprising enolase 1 (Eno1) or a fragment thereof and a muscle targeting peptide, wherein the Eno1 or a fragment thereof and the muscle targeting peptide are in a complex;wherein the Eno1 or a fragment thereof has glycolytic activity and is present in a therapeutically effective amount; and
wherein the muscle targeting peptide is a smooth muscle targeting peptide, a skeletal muscle targeting peptide, or a smooth muscle and skeletal muscle targeting peptide.
US Pat. No. 10,189,993

SILOXANE COMPOSITION AND METHOD FOR PRODUCING SAME

SHIN-ETSU CHEMICAL CO., L...

1. A method of preparing a siloxane composition, comprising:a step of producing a crosslinked organopolysiloxane having a weight-average molecular weight of 5,000 to 300,000,000 and containing 0.1 to 50 moles of silethylene linkages per 1,000 moles of siloxane units by hydrosilylation of an organopolysiloxane having a structure of formula (1) below with an organohydrogenpolysiloxane having a structure of formula (2) below
M?MVi?D?DVi?T?TVi?Q?  (1)
M?MH?D?DH?T?TH?  (2)(wherein M is R3SiO1/2, MVi is R2PSiO1/2, D is R2SiO2/2, DVi is RPSiO2/2, T is RSiO3/2, TVi is PSiO3/2, MH is R2HSiO1/2, DH is RHSiO2/2, TH is HSiO3/2 and Q is SiO4/2, each R being independently an unsubstituted or substituted monovalent hydrocarbon group of 1 to 12 carbon atoms that has no aliphatic unsaturated bonds and P being an alkenyl group represented by —(CH2)a—CH?CH2 (where “a” is 0 or an integer from 1 to 6); and ?, ?, ?, ?, ?, ?, ?, ?, ?, ?, ?, ? and ? are each independently 0 or a positive number, with the provisos that ?, ? and ? are not all 0, ?+?+??2, ?, ? and ? are not all 0, and ?+?+??2) in an amount of solvent that is at least 8 times the combined weight of the polysiloxanes of formulas (1) and (2) and using a platinum group metal compound, andafter obtaining the crosslinked organopolysiloxane using an organic solvent selected from among toluene, hexane, xylene and methyl ethyl ketone as the solvent: adding a low-viscosity organopolysiloxane as a solvent, and distilling off the organic solvent by heating under reduced pressure so as to give a composition that contains no organic solvent.
US Pat. No. 10,190,002

AQUEOUS MULTI-STAGE EMULSION COPOLYMER COMPOSITIONS FOR USE IN JOINERY APPLICATIONS

Rohm and Haas Company, P...

1. An aqueous composition comprising aqueous multistage emulsion copolymer compositions comprising (a) one or more dihydrazide compounds in a total amount of from 0.5 to 4 wt. %, based on the total weight of composition solids, and (b) of one or more aqueous multistage emulsion copolymers containing, as (i) a first stage, an emulsion copolymer having a glass transition temperature (Tg) via differential scanning calorimetry (DSC) of from ?50 to 30° C., and containing, in copolymerized form, from 0.5 to 3.0 wt. % of one or more monoethylenically unsaturated phosphorous acid monomers and, from 0.75 to 5 wt. % of one or more keto group containing amide monomers, and, as (ii) a second stage, an emulsion copolymer having a DSC Tg of from 50° C. to 125° C., wherein the Tg difference between the first stage and the second stage is from 45° C. to 150° C. having a weight ratio of (i) the first stage to (ii) the second stage, based on copolymer solids, ranging from 50:50 to 90:10 or, all monomer wt. % s based on the total weight of monomers used to make the aqueous multistage emulsion copolymer, and, further wherein, the (ii) second stage of the aqueous multistage emulsion copolymer comprises, in copolymerized form, no more than 25 wt. % of the total monoethylenically unsaturated phosphorous acid monomers used to make the aqueous multistage emulsion copolymer, and no more than 50 wt. % of the total keto group containing amide monomers used to make the aqueous multistage emulsion copolymer, and wherein (b) at least one of the one or more aqueous multistage emulsion copolymer comprises, in copolymerized form, at least 90 wt. % of the one or more monoethylenically unsaturated phosphorous acid monomers in the (i) first stage.
US Pat. No. 10,188,723

FUNCTIONAL INFLUENZA VIRUS LIKE PARTICLES (VLPS)

NOVAVAX, INC., Gaithersb...

1. A vaccine comprising an influenza VLP, wherein said VLP comprises influenza proteins, wherein the influenza proteins consist of M1, HA and NA proteins; wherein the M1 protein is derived from a different influenza virus strain than the HA and NA proteins; wherein the influenza proteins are insect-cell expressed, and wherein the M1 protein is from an avian influenza strain.
US Pat. No. 10,190,261

STRENGTHENING RESINS FOR PAPER PRODUCTS

ECOLAB USA INC., St. Pau...

1. A fiber mixture, comprising:a plurality of fibers; and
a resin composition comprising:
about 10 wt % to about 80 wt % of a polyamide-epihalohydrin resin comprising a reaction product of a polyamidoamine and an epihalohydrin;
about 10 wt % to about 80 wt % of a cationic styrene maleimide resin comprising a reaction product of a styrene maleic anhydride copolymer and an amine compound; and
about 10 wt % to about 80 wt % of a urea-formaldehyde resin, wherein the weight percent values of the polyamide-epihalohydrin resin, the cationic styrene maleimide resin, and the urea-formaldehyde resin are based on a combined solids weight of the polyamide-epihalohydrin resin, the cationic styrene maleimide resin, and the urea-formaldehyde resin.
US Pat. No. 10,188,726

SYNTHETIC HEPATITIS C POLYPEPTIDE AND METHODS OF MAKING AND USING SAME

The Johns Hopkins Univers...

1. The polypeptide encoded by a nucleic acid comprising SEQ ID NO: 1, encoding the genome of the synthetic hepatitis C virus subtype 1a (Bole 1a).
US Pat. No. 10,188,984

PROCESS FOR REMOVING OXIDISABLE GASEOUS COMPOUNDS FROM A GAS MIXTURE BY MEANS OF A PLATINUM-CONTAINING OXIDATION CATALYST

1. A process for catalytic oxidative removal of at least one oxidisable gaseous compound from a gas mixture, the gas mixture comprising the at least one oxidisable gaseous compound as well as oxygen, the process comprising:reacting H2Pt(OH)6 with oxalic acid in an aqueous solution to form platinum oxalate complexes of the formula (H3O)1.6[Pt(C2O4)2]. 2H2O;
forming an oxidation catalyst by adding the platinum oxalate complexes to a porous catalyst support and exothermically decomposing the platinum oxalate complexes to generate catalytically active platinum species; and
oxidizing the gas mixture with the oxidation catalyst, wherein
the gas mixture is not a combustion flue gas.
US Pat. No. 10,188,729

MODULATION OF TUMOR IMMUNITY

1. A method of treating a tumor in a patient comprising administering to the patient a bispecific antibody comprising(i) a first arm having a light chain (LC) variable region that comprises the amino acid sequences of CDR-L1, CDR-L2 and CDR-L3 of an LC variable region having the amino acid sequence of the LC variable region of MK-3475 and a heavy chain (HC) variable region that comprises the amino acid sequences of CDR-H1, CDR-H2 and CDR-H3 of an HC variable region having the amino acid sequence of the HC variable region of MK-3475; and
(ii) a second arm having an LC variable region that comprises the amino acid sequences of CDR-L1, CDR-L2 and CDR-L3 of an LC variable region having the amino acid sequence set forth in SEQ ID NO: 82 wherein residue 31 is Q and residue 57 is Q; and an HC variable region that comprises the amino acid sequences of CDR-H1, CDR-H2 and CDR-H3 of an HC variable region having the amino acid sequence set forth in SEQ ID NO: 81.
US Pat. No. 10,193,094

ORGANIC LIGHT-EMITTING DEVICE HAVING DELAYED FLUORESCENCE

Merck Patent GmbH, (DE)

1. An organic electroluminescent device comprisinganode,
cathode,
at least one emitting layer which comprises a luminescent organic compound E which has a difference between the energies of its S1 and T1 states of not greater than 0.15 eV, and
2, 3, 4 or 5 layers H each having a thickness of greater than 2 nm which are arranged between one emitting layer of said at least one emitting layer, which is closest to said anode, and said anode,
where the following conditions apply to each layer H:
a difference D between the HOMO energy level of a layer H and the HOMO energy level of the closest layer having a thickness of greater than 2 nm on a cathode side of this layer H must be less than or equal to 0.4 eV, and
each of the layers H comprises at least one triarylamino compound which is a small organic molecule,
with the proviso that, for layers whose HOMO energy level has a value of less than ?6.7 eV, the LUMO energy level for the said condition occurs instead of the HOMO energy level and wherein the emitting layer which comprises compound E additionally comprises one or more matrix materials, and in that compound E is an emitting compound and the energy of the T1 state of the matrix material of the emitting layer is at most 0.1 eV lower than the energy of the T1 state of compound E.
US Pat. No. 10,190,020

SILOXANE-BASED COATINGS CONTAINING POLYMERS WITH UREA LINKAGES AND TERMINAL ALKOXYSILANES

The United States of Amer...

8. A composition comprising:an amine-functional compound or an epoxy- or acrylate-functional compound; and
a urea-containing composition made by a method comprising:
reacting an amino-functional alkoxysilane with a first polyisocyanate to form one or more adducts having an unreacted isocyanate group; and
reacting the adducts with one or more polyfunctional amino- and/or hydroxyl compounds and a second polyisocyanate to form the urea-containing composition;
wherein the urea-containing composition comprises at least two residues of the polyfunctional amino- and/or hydroxyl compounds;
wherein isocyanate groups do not react with other isocyanate groups; and
wherein the urea-containing composition contains no unreacted isocyanate groups;
wherein the urea-containing composition is characterized by any of:
a) at least one of the polyfunctional amino- and/or hydroxyl compounds comprises an amino group and at least one of the polyfunctional amino- and/or hydroxyl compounds comprises a hydroxyl group;
b) at least one of the polyfunctional amino- and/or hydroxyl compounds is a polyfunctional amino compound; and
c) the urea-containing composition comprises one of more compounds having the formula:
{[(R1O)aR13-aSi—(CH2)3—NR2—CO—NH]n—R3—NH—CO—X—R5—X—CO—NH}m—R3
wherein each a is independently selected from 1, 2, or 3;
wherein m is 2 or 3;
wherein each n is independently selected from 1 or 2;
wherein each X is independently selected from —NR4— and —O—;
wherein each R1 group is an independently selected alkyl group;
wherein each R2 and R4 is independently selected from hydrogen, aryl, alkyl, cycloalkyl, ester-containing aliphatic, ester-containing fluorinated aliphatic, amide-containing aliphatic, and polysiloxane;
wherein each R3 is an independently selected residue of an aliphatic, cycloaliphatic, or aromatic polyisocyanate having 2 or 3 isocyanate groups; and
wherein each R5 independently comprises a group selected from aliphatic, cycloaliphatic, aromatic, polyester, polyether, polysulfide, polyurethane, polycarbonate, polysiloxane, and any combination thereof moisture-curing the composition.
US Pat. No. 10,193,097

LIGHT-EMITTING ELEMENT, LIGHT-EMITTING DEVICE, AND ELECTRONIC DEVICE

Semiconductor Energy Labo...

10. A light-emitting element comprising:a first electrode;
a hole-injecting layer over the first electrode
a hole-transporting layer over the hole-injecting layer;
a light-emitting layer over the hole-transporting layer;
an electron-transporting layer over the light-emitting layer;
an electron-injecting layer over the electron-transporting layer;
a second electrode over the electron-injecting layer;
a first layer between the hole-transporting layer and the light-emitting layer; and
a second layer between the light-emitting layer and the electron-transporting layer,
wherein:
the light-emitting layer includes a first phosphorescent compound,
the first layer includes a first hole-transporting material and a first electron-transporting material,
the second layer includes a second hole-transporting material and a second electron-transporting material,
the second hole-transporting material includes a second phosphorescent compound,
in the first layer, a concentration of the first hole-transporting material is higher than that of the first electron-transporting material,
in the second layer, a concentration of the second electron-transporting material is higher than that of the second hole-transporting material, and
a difference between a wavelength of a highest peak of an emission spectrum of the second phosphorescent compound and a wavelength of a highest peak of an emission spectrum of the first phosphorescent compound is within 30 nm.
US Pat. No. 10,188,740

MODIFIED FC MOLECULES

AMGEN INC., Thousand Oak...

1. A composition of matter comprising:(i) a monomeric or multimeric Fc domain having a cysteine or non-canonical amino acid substitution at one or more specifically selected conjugation site(s) selected from D46, S48, H49, E50, E53, K55, D61, G62, Q76, Y81, K107, K121, G122, Q123, E126, R136, D137, T140, K141, N142, E169, N170, N171, K173, L179, S181, G183, D194, K195, R197, Q199, Q200, G201, N202, or S223, relative to reference sequence SEQ ID NO:599; and
(ii) at least one additional functional moiety, wherein the functional moiety is conjugated to the Fc domain through the side chain of the cysteine residue or non-canonical amino acid residue substituted at said one or more conjugation site(s).