US Pat. No. 10,988,879

SEWING MACHINE AND HOLDER MEMBER

BROTHER KOGYO KABUSHIKI K...

1. A sewing machine provided with a sewing portion that sews a sewing object, the sewing machine comprising:an imaging unit having a predetermined image capture range, and configured to capture an image of a holder member, the holder member being configured to hold an object of image capture;
a conveyor portion configured to convey the holder member relative to the imaging unit in a first direction and a second direction that are different from each other;
a processor; and
a memory stores computer-readable instructions that, when executed by the processor, instruct the sewing machine to perform processes comprising:
causing the imaging unit to capture the image of the holder member that has entered the image capture range by controlling the imaging unit and the conveyor portion;
acquiring first image data that is data of a first image representing the image of the holder member that was captured by the imaging unit;
identifying a predetermined marker from the first image of the acquired first image data; and
determining whether an inclination angle of the holder member exceeds a predetermined value on the basis of a variable acquired on the basis of the identified marker, the variable being a variable corresponding to a degree of inclination of the holder member that inclines with respect to the first direction, the holder member being inclined toward a third direction orthogonal to the first direction and the second direction.

US Pat. No. 10,988,877

OVERLOCK SEWING MACHINE

JANOME SEWING MACHINE CO....

1. An overlock sewing machine comprising:an upper blade configured such that it can be moved between an interlock position at which it is driven in an upper-lower direction together with a rotation of a main shaft and a retraction position to which it is to be retracted downward from the interlock position;
a rod configured such that it extends in a direction that is orthogonal to an axial direction of the main shaft, and arranged such that one end portion is coupled to the main shaft by an eccentric cam, which allows the rod to be swung by a driving force applied by the main shaft;
a swing member supported by a support shaft arranged in parallel with the axial direction of the main shaft such that it can be swung, coupled to the upper blade via another member, comprising a fitting portion configured such that it can be fitted into a fitting target portion provided to the other end portion of the rod, and configured such that, when the fitting portion is fitted into the fitting target portion, the swing member is reciprocally swung accompanying a swinging of the rod according to a rotation of the main shaft, so as to drive the upper blade in the upper-lower direction when the upper blade is set to the interlock position;
an interlock switching mechanism configured to operate to switch a state to an interlock state in which the fitting target portion is fitted into the fitting portion so as to allow the upper blade to be driven together with the main shaft or otherwise an interlock release state in which a fitting state between the fitting target portion and the fitting portion is released so as to release the interlock state;
a position switching mechanism configured to operate such that a position of the upper blade is switched to the retraction position or otherwise the interlock position; and
an operating shaft configured to be rotated so as to operate the interlock switching mechanism and the position switching mechanism,
wherein the position switching mechanism comprises:
a first switching portion provided such that it can be rotated together with the swing member as a single unit;
a second switching portion provided on a reverse swing side of the swing member with respect to the first switching portion; and
a pressing portion provided at a position that is eccentric with respect to the operating shaft such that it can be rotated together with the operating shaft as a single unit, and configured to be capable of pressing the first switching portion and the second switching portion,
wherein, when the interlock state is set and the upper blade is set to the interlock position, upon turning the operating shaft toward one side around the axis of the operating shaft, the interlock switching mechanism displaces the other end portion of the rod so as to set the interlock release state, and the pressing portion presses the first switching portion such that the first switching portion swings the swing member toward a forward swing side, which moves the upper blade to the retraction position,
and wherein, when the interlock release state is set and the upper blade is set to the retraction position, upon turning the operating shaft toward the one side around the axis of the operating shaft, the pressing portion presses the second switching portion such that the second switching portion swings the swing member toward the reverse swing side, which moves the upper blade to the interlock position, and the interlock switching mechanism displaces the other end portion of the rod so as to set the interlock state.

US Pat. No. 10,988,876

CUSHION PAPER

Tomoegawa Co., Ltd, Toky...

1. A cushion member comprising a non-woven fabric formed by binding or entangling metal fibers having an average diameter of 8 ?m to 18.5 ?m, whereinwhen the cushion member is compressed, the cushion member undergoes compressive deformation and the following compressive deformation ratio is 5% to 80%:
compressive deformation ratio=(T0?T1)/T0×100,
T0: film thickness of cushion member before application of load, and
T1: film thickness of cushion member after application and release of load,
wherein the film thickness of the cushion member before application and release of load is measured by moving a probe of a digital indicator so that only a weight of the probe itself is applied to a test piece of the cushion member,
the film thickness of the cushion member after application and release of load is measured after three-times compression at 1 kN load, a compression rate of 1 mm/min, and a gradual increase of a compression stress from 0 MPa to 1 MPa, thereby obtaining a stress-strain chart from which an actual strain to stress is calculated and an amount of compressive deformation is calculated in accordance with the following expression:
amount of compressive deformation=(strain at the first time rising portion)?(strain at the second rising portion).

US Pat. No. 10,988,875

APPARATUS FOR TREATING A MINERAL FIBER MAT BY DETECTING AND REMOVING LOCALISED DEFECTS, AND CORRESPONDING METHOD

SAINT-GOBAIN ISOVER, Cou...

1. An apparatus for treating a mat of mineral fibers moving along a plane and a run direction, by detection and elimination of localized defects, the apparatus comprising:a first member for transporting the mat of mineral fibers,
a second member for transporting the mat of mineral fibers, the second transport member being positioned after the first transport member in the run direction and separated therefrom in said run direction by a treatment zone,
a device for detecting localized defects in the mat of mineral fibers, located upstream of the treatment zone in the run direction, and
the treatment zone, a device for eliminating defects suitable for eliminating, in-line, during transportation of the mat of fiber materials and without interruption of the transportation, a defect detected by the detection device by eliminating a portion of mat containing the defect.

US Pat. No. 10,988,874

REUSE OF USED WOVEN OR KNITTED TEXTILE

REALLY APS, Frederiksber...

1. A method of manufacturing a product from used woven or knitted textile comprising vegetable or animal fibers, the method comprising the steps of:collecting different types of used woven or knitted textiles into a least first and second textile collections, said first and second textile collections being different from each other by having different types of used woven or knitted textile,
granulating said first and second textile collections into fibers having an average fiber length of between 3.5 mm and 5.5 mm,
separately mixing each of said granulated first and second textile collections said with a thermoplastic fiber based binder and a coupling agent to form first and second mixtures, respectively, and
forming a nonwoven mat from the first and second mixtures,
wherein said nonwoven mat comprises 59% to 67% by weight of vegetable fiber, or alternatively said nonwoven mat comprises at least 80% by weight animal fibers,
wherein the step of forming said nonwoven mat comprises substeps of:
forming at least one first precursor nonwoven mat from said first mixture and at least one second precursor nonwoven mat from said second mixture, and
arranging said at least one first precursor nonwoven mat and said at least one second precursor nonwoven mat on top of each other to form said nonwoven mat, and
wherein said method further comprises the step of:
heating said nonwoven mat to at least 140° C., and
wherein said nonwoven mat comprises about 3% by weight of the coupling agent.

US Pat. No. 10,988,870

DEVICE FOR CUTTING THROUGH PILE THREADS ON A WEAVING MACHINE

NV MICHEL VAN DE WIELE

1. Device for cutting through pile threads on a weaving machine, comprisinga cutter, which is displaceable back and forth according to a substantially rectilinear motion path,
a transmission body in connection with the cutter, and
a rotatable drive, which is drivable so as to rotate alternately in one and another rotational direction,
wherein the drive and the transmission body are provided to interact in order to convert the rotation motions of the drive, via the transmission body, into a back-and-forth displacement of the cutter,
wherein the device is provided to exert by a rotary motion of the drive, via the transmission body, a pushing force on the cutter, and
wherein the transmission body is flexible over at least a portion of its length.

US Pat. No. 10,988,868

TEXTILE STRUCTURES COMPRISING CORE SPUN YARNS AND ASSOCIATED METHODS FOR MANUFACTURE

Sysco Guest Supply, LLC, ...

1. A sheeting fabric comprising:one or more layers of warp yarns; and
one or more layers of weft yarns interwoven with the one or more layers of warp yarns,
wherein the one or more layers of warp yarns consist essentially of core spun yarns and the one or more layers of weft yarns consist essentially of non-core spun yarns, wherein the core spun yarns consist essentially of a polyester filament core and a cotton sheath, and the non-core spun yarns consist essentially of polyester yarns,
wherein the wefts per inch consisting essentially of the non-core spun yarns is 10-20 percent less than the warps per inch consisting essentially of the core spun yarns,
wherein the non-core spun yarns are selected from spun yarns and filament yarns,
wherein a total thread count of the sheeting fabric is between 120 and 400,
wherein the sheeting fabric further comprises core spun yarns in the range of 50-60% by weight.

US Pat. No. 10,988,864

DEVICE FOR ENTANGLING A PLURALITY OF INDIVIDUAL THREADS OF A COMPOSITE THREAD

1. Device for entangling a plurality of individual threads of a composite thread in a melt-spinning process for the production of crimped yarns, havinga plurality of entanglement nozzles which are collectively held on a support, each entanglement nozzle having a separate placing slot,
wherein the entanglement nozzles on the support are assigned at least one thread guide, the entanglement nozzles and the at least one thread guide providing respective ducts in such a manner that the ducts guide the threads optionally in the entanglement nozzles and/or in the thread guide, and
a guide groove for each thread guide, and
wherein the guide groove opens into a respective thread guide of the at least one thread guide, and wherein one of the placing slots opens into the guide groove.

US Pat. No. 10,988,863

CARD WIRE

Groz-Beckert KG, Albstad...

1. Card wire (1) comprising in its longitudinal direction (L), consecutive teeth (2) which are spaced apart in the longitudinal direction (L) by a pitch (3),wherein the teeth (2) are bounded in the longitudinal direction (L) by a tooth face (4) on a first side and by a tooth back (5) on a second side,
wherein, looking downwards in a height direction (H) of the card wire (1), the tooth face (4) and the tooth back (5) of consecutive teeth (2) merge in a tooth base (6) and, looking upwards in the height direction (H) of the card wire (1), form a tooth tip (8),
wherein a tooth depth (7) is defined by a greatest distance, in the height direction (H) of the card wire (1), from the tooth tip (8) to the tooth base (6),
wherein a ratio of pitch (3) to tooth depth (7) is less than 1.1,
wherein an interspace (9), measured at right angles to a tangent to an inflection point (10) between tooth back (5) and tooth base (6), between this inflection point (10) and an opposite tooth face (4) is greater than a quarter of the pitch (3),
wherein the tooth base (6) is shaped as an arc having a radius greater than one or both of one eighth of the pitch (3) or 0.4 mm.

US Pat. No. 10,988,861

APPARATUS FOR MAKING A SPUNBOND WEB FROM FILAMENTS

7. An apparatus for making a spunbond web, the apparatus comprising:means for supplying polypropylene having an average isotactic sequence length of at least 65 and an onset temperature of at least 120°;
a spinneret having a nozzle plate forming a plurality of nozzle holes homogeneously distributed across the entire nozzle plate and connected to the means for heating for receiving the heated polypropylene and extruding filaments of the heated polypropylene through the homogeneously distributed nozzle holes such that the filaments travel in a flow direction and are spaced apart homogeneously in a direction transverse to the flow direction;
a monomer suction device downstream of the spinneret and through which the homogeneously spaced and extruded filaments move in the flow direction;
a cooling chamber downstream of the monomer suction device and divided into upper and lower cooling compartments through which the filaments move in the direction after exiting the monomer suction device;
blower means for
feeding cool process air into the cooling chamber to cool the filaments in the compartments thereof,
sucking a portion from the upper cooling compartment and into the monomer suction device at a volumetric flow rate VM,
feeding another portion of the process air from the upper compartment at a volumetric flow rate V1 into the lower cooling compartment,
withdrawing process air from the lower cooling compartment at a volumetric flow rate V2;
control means connected to the blower means for setting the flow rates relative to each other such that a volumetric flow-rate ratio VM/V1 is 0.1 to 0.3 and a volumetric flow-rate ratio V1/V2 is 0.1 to 0.45;
a stretcher downstream of the lower cooling compartment for receiving and stretching the filaments therefrom; and
a deposition device downstream of the stretcher for receiving the stretched filaments.

US Pat. No. 10,988,860

METHOD FOR MANIPULATING CRYSTAL MORPHOLOGY TO ACHIEVE STABLE FLUIDIZATION

American Electric Power C...

1. A method for manipulating crystal structure to fluidize a powder comprising:collecting a powder comprising a crystal structure in a vessel wherein the vessel comprises an exterior wall and an interior volume and wherein the powder forms a powder bed within the interior volume;
injecting a heated compressed gas into the vessel by way of one or more gas inlet ports; and
agitating and heating the powder with the heated compressed gas to bring an average temperature of the powder to least a predetermined transition temperature, so as to transform the crystal structure of substantially all of the powder so that the crystal structure is transmuted to facilitate an improvement in flowability relative to the former crystal shape.

US Pat. No. 10,988,859

NITROGEN DOPED AND VACANCY DOMINATED SILICON INGOT AND THERMALLY TREATED WAFER FORMED THEREFROM HAVING RADIALLY UNIFORMLY DISTRIBUTED OXYGEN PRECIPITATION DENSITY AND SIZE

GlobalWafers Co., Ltd., ...

1. A method of controlling an edge band of oxygen precipitates in wafers sliced from a nitrogen-doped silicon crystal ingot grown by the Czochralski process and thermally treated at 780° C. for 3 hours and then at 1000° C. for 16 hours wherein the method is implemented by a computing device including a processor coupled to a memory, the method comprising:determining, by the computing device, by simulation, a combination of (i) nitrogen-doped silicon crystal ingot diameter, (ii) nitrogen-doped silicon crystal ingot pull rate or nitrogen-doped silicon crystal ingot pull rate range, (iii) nitrogen-doped silicon crystal ingot nitrogen concentration or nitrogen-doped silicon crystal ingot nitrogen concentration range, and (iv) nitrogen-doped silicon crystal ingot surface temperature gradient or nitrogen-doped silicon crystal ingot surface temperature range that enables the preparation of a nitrogen-doped CZ silicon crystal ingot from molten silicon by the Czochralski process wherein a thermally treated wafer sliced therefrom having an edge band in a region extending from about 1000 ?m to the edge of said wafer and to the edge of said wafer and is characterized by oxygen precipitates having an average diameter of from about 80 nm to about 90 nm and an oxygen precipitate density of from about 1*108 atoms per cm3 to about 1*1010 atoms per cm3,
wherein the simulation comprises at least one iteration of a simulation scheme comprising:
(1) receiving, by the computing device, values for at least (i) a nitrogen-doped silicon crystal ingot diameter, (ii) a nitrogen-doped silicon crystal ingot pull rate or a nitrogen-doped silicon crystal ingot pull rate range, (iii) a nitrogen-doped silicon crystal ingot nitrogen concentration or a nitrogen-doped silicon crystal ingot nitrogen concentration range and (iv) a nitrogen-doped silicon crystal ingot surface temperature gradient or a nitrogen-doped silicon crystal surface ingot temperature gradient range, and simulating, by the computing device, a thermally treated wafer radial bulk micro defect size distribution in a region extending from the center of said wafer to the edge of said wafer based on the received values;
(2) receiving, by the computing device, values for at least (i) the nitrogen-doped silicon crystal ingot diameter, (ii) the nitrogen-doped silicon crystal ingot pull rate or the nitrogen-doped silicon crystal ingot pull rate range and (iii) the nitrogen-doped silicon crystal ingot nitrogen concentration or the nitrogen-doped silicon crystal ingot nitrogen concentration range, and simulating, by the computing device, a thermally treated wafer radial bulk micro defect density distribution in a region extending from the center of said wafer to the edge of said wafer based on the received values;
(3) receiving, by the computing device, values for at least (i) the nitrogen-doped silicon crystal ingot diameter, (ii) the nitrogen-doped silicon crystal ingot pull rate or the nitrogen-doped silicon crystal ingot pull rate range, (iii) the nitrogen-doped silicon crystal ingot nitrogen concentration or the nitrogen-doped silicon crystal ingot nitrogen concentration range and (iv) the nitrogen-doped silicon crystal ingot surface temperature gradient or the nitrogen-doped silicon crystal ingot surface temperature gradient range and simulating, by the computing device, a thermally treated wafer oxygen precipitation density distribution in a region extending from the center of said wafer to the edge of said wafer; and
(4) simulating, by the computing device, the average size of the thermally treated wafer edge band oxygen precipitates based on the simulated values for (i) the thermally treated wafer radial bulk micro defect size distribution from the center of said wafer to the edge of said wafer, (ii) the thermally treated wafer radial bulk micro defect density distribution from the center of said wafer to the edge of said wafer, and (iii) the thermally treated wafer oxygen precipitation density distribution in a region extending from the center of said wafer to the edge of said wafer, wherein the computing device predicts the thermally treated wafer edge band by simulation to comprise oxygen precipitates having an average diameter of from about 80 nm to about 90 nm and an oxygen precipitate density of from about 1*108 atoms per cm3 to about 1*1010 atoms per cm3, and
wherein the process of producing the nitrogen-doped silicon crystal ingot by the Czochralski process comprises:
forming the molten silicon in a crucible within a growth chamber;
doping the silicon melt with nitrogen by flowing nitrogen gas into the growth chamber, adding nitrogen to the silicon melt, or a combination of flowing nitrogen gas into the growth chamber and adding nitrogen to the silicon melt;
dipping a single crystal silicon seed crystal into the melt;
pulling the single crystal seed crystal to thereby form a conical neck of increasing diameter by decreasing the pull rate of the crystal;
pulling the nitrogen-doped silicon crystal ingot from the molten silicon at a pull rate range between about 0.78 mm per minute to 1.0 mm per minute, a temperature gradient between about 30° K per cm to about 50° K per cm, and at an average crystal ingot surface temperature range of from about 1300° C. to about 1415° C. to produce a substantially constant diameter region of the nitrogen-doped CZ silicon crystal ingot from which the treated wafers are produced, wherein (i) the substantially constant diameter region of the nitrogen-doped silicon crystal ingot has a diameter between about 150 mm to about 450 mm, (ii) the nitrogen concentration in the substantially constant diameter region of the nitrogen-doped silicon crystal ingot is from 1*1014 atoms per cm3 to about 1*1015 atoms per cm3, and (iii) a portion of the substantially constant diameter region of the nitrogen-doped silicon crystal ingot comprises vacancies as the predominant intrinsic point defect; and
cooling the substantially constant diameter region of the nitrogen-doped silicon crystal ingot;
wherein the thermally treated wafer sliced from the nitrogen-doped silicon crystal ingot has an edge band in a region extending from about 1000 ?m to the edge of said wafer and to the edge of said wafer and is characterized by oxygen precipitates having an average diameter of from about 80 nm to about 90 nm and an oxygen precipitate density of from about 1*108 atoms per cm3 to about 1*1010 atoms per cm3.

US Pat. No. 10,988,858

METHOD FOR DEPOSITING A CRYSTAL LAYER AT LOW TEMPERATURES, IN PARTICULAR A PHOTOLUMINESCENT IV-IV LAYER ON AN IV SUBSTRATE, AND AN OPTOELECTRONIC COMPONENT HAVING SUCH A LAYER

1. A method for monolithically depositing a monocrystalline IV-IV layer that glows when excited and that is composed of a plurality of elements of the IV main group, having a dislocation density less than 106 cm?2, on a IV substrate, of atoms of the IV main group, comprising the following steps:providing a hydride of a first element (A) being C, Si, or Ge, with a structure AnHm, wherein n, m are natural numbers;
providing a chloride of a second element (B) being C, Si, Ge, or Sn, with a structure BkCll, wherein k, l are natural numbers;
decomposing the hydride such that the hydride produces a radical with a structure AnHm?, wherein m? is a natural number less than m;
heating a susceptor which holds the IV substrate to a susceptor temperature that is between 300° C. and 400° C.;
producing a carrier gas flow of an inert carrier gas;
transporting the chloride and the radical of the hydride to a surface of the IV substrate at a total pressure of at most 300 mbar;
decomposing the first element (A) from the radical of the hydride and decomposing the second element (B) from the chloride, wherein said step of decomposing includes:
producing heat from an exothermic reaction between the radical of the hydride and the chloride at the surface of the IV substrate, wherein atoms of the first element (A) and atoms of the second element (B) remain at the surface of the IV substrate as a reaction product, and
absorbing the heat at a same time as the exothermic reaction by an endothermic reaction at the surface of the IV substrate, wherein the endothermic reaction is a decomposition reaction of the radical of the hydride, wherein atoms of the first element (A) remain at the surface of the IV substrate; and
depositing the first element (A) and the second element (B) to form the monocrystalline IV-IV layer on the surface of the IV substrate, the monocrystalline IV-IV layer having a thickness of at least 200 nm, wherein the heat released by the exothermic reaction heats the surface of the monocrystalline IV-IV layer to grow a crystal layer in a non-equilibrium state.

US Pat. No. 10,988,855

PLATING DEVICE

YAMAMOTO-MS Co., Ltd., T...

1. A plating apparatus comprising:an anode and a pair of cathodes which are provided in a plating bathtub;
a plating power source for supplying an electric current between the anode and the pair of cathodes; and
a feedback circuit to have an electrode potential of a first cathode of the pair of cathodes equal to an electrode potential of a second cathode of the pair of cathodes while a summation of electric currents flowing through the pair of cathodes is kept constant.

US Pat. No. 10,988,853

STAINLESS STEEL SHEET INCLUDING NI AND O-CONTAINING COATING ON SURFACE AND METHOD FOR PRODUCING STAINLESS STEEL SHEET

JFE STEEL CORPORATION, T...

1. A stainless steel sheet comprising a Ni and O-containing coating on a surface of the stainless steel sheet,wherein the Ni and O-containing coating has a coating weight of greater than or equal to 0.1 g/m2 and less than or equal to 20 g/m2, and
the Ni and O-containing coating has a composition including, in at. %, Ni: greater than or equal to 25% and less than or equal to 60%, and O: greater than or equal to 40% and less than or equal to 70%.

US Pat. No. 10,988,852

METHOD OF ELECTROPLATING COPPER INTO A VIA ON A SUBSTRATE FROM AN ACID COPPER ELECTROPLATING BATH

Rohm and Haas Electronic ...

1. A method of filling a through-silicon via in an electronic device with copper comprising:a) providing an acid copper electroplating bath comprising a source of copper ions, an acid electrolyte, a source of halide ions, an accelerator, a leveler, a primary alcohol alkoxylate block copolymer having a formula:
wherein R is a linear or branched (C1-C15) alkyl moiety or a linear or branched (C2-C15) alkenyl moiety and m and n can be the same or different and are moles of each moiety wherein the primary alcohol alkoxylate has a weight average molecular weight of 500 g/mole to 20,000 g/mole and a random or block alkoxylate copolymer comprising ethylene oxide and propylene oxide moieties wherein the random or block alkoxylate copolymer has an HLB of 16 to 35 and the copper electroplating bath has a surface tension ?40 mN/m;b) providing as a cathode an electronic device substrate having one or more through-silicon vias to be filled with copper and having a conductive surface, wherein the through-silicon via have depths of 5 to 600 ?m and diameters of 1 to 200 ?m;
c) contacting the electronic device substrate with the copper electroplating bath; and
d) applying a potential for a period of time sufficient to fill the through-silicon vias with a copper deposit; wherein the copper deposit in the through-silicon vias is substantially void-free and substantially free of surface defects.

US Pat. No. 10,988,851

METHOD FOR MANUFACTURING COMPOSITION CONTROLLED THIN ALLOY FOIL BY USING ELECTRO-FORMING

DANKOOK UNIVERSITY CHEONA...

1. A method of manufacturing an alloy thin film, the method comprising:(a) a step of electroforming a multilayer that comprises two or more different thin metal film layers in which nano-scale cracks generated by hydrogen generation are controlled; and
(b) a step of hot-rolling or thermally treating the multilayer during or after the electroforming of the multilayer such that interdiffusion among the two or more different thin metal film layers is facilitated and nano-scale cracks generated by hydrogen generation are removed by compression,
wherein, in step (a), a layer number and thickness of the multilayer are controlled to a nano-sized thickness through application of various types of pulses;
wherein the multilayer of step (a) is manufactured to have a desired alloy composition by alternately, repeatedly laminating different types of thin metal layers,
wherein each layer of the different thin metal layers is laminated by applying a pulse current density having various pulse waveforms, different electric potentials, and different pHs,
wherein the multilayer is formed using electroforming applying the pulse current density simultaneously with an ultrasonic pulse,
wherein the ultrasonic pulse is used to control nano-scale cracks in the multilayer generated by hydrogen generation, and
wherein the thermally treating of step (b) is performed during rolling.

US Pat. No. 10,988,847

APPARATUS AND METHOD OF PREPARING CARBONATE AND/OR FORMATE FROM CARBON DIOXIDE

KOREA INSTITUTE OF ENERGY...

1. An apparatus for preparing carbonate and/or formate from carbon dioxide (CO2), comprising:an electrolysis reactor comprising (i) an anode which contains an aqueous solution of a Group I metal salt as an electrolytic solution, (ii) an ion-exchange membrane through which metal cations derived from the Group I metal salt and water flow from the anode to a cathode, (iii) the cathode, and (iv) a gas diffusion layer which supplies a carbon dioxide-containing gas to the cathode;
a power supply unit for applying a voltage between the anode and the cathode;
a first gas-liquid separator for recovering the electrolytic solution from products formed in the anode;
a second gas-liquid separator for recovering carbonate and/or formate from products formed in the cathode;
an ion electrode for measuring the concentration of the carbonate and/or formate recovered from the second gas-liquid separator;
a pH meter for measuring a pH of the electrolytic solution recovered from the first gas-liquid separator;
a first reactant supply unit for supplying (a) the electrolytic solution recovered from the first gas-liquid separator and (b) the aqueous solution of the Group I metal salt with which the recovered electrolytic solution is replenished according to the pH of the electrolytic solution, to the anode; and
a second reactant supply unit for supplying carbon dioxide or a mixture comprising carbon dioxide and water vapor to the cathode;
wherein, when a voltage is applied between the anode and the cathode,
in the anode, water undergoes electrolysis to generate hydrogen ions, oxygen, and electrons, and the metal cations in the Group I metal salt are substituted with the hydrogen ions, while the generated metal cations move to the cathode through the ion-exchange membrane and the electrons move to the cathode through an external electric line; andin the cathode, the carbon dioxide, water, metal cations, and electrons are reacted and produce carbonate and/or formate;wherein the apparatus is configured to supply water to the cathode from the anode through the ion-exchange membrane;
wherein the apparatus does not comprise a unit for supplying a cathode electrolytic solution to the cathode;
wherein the electrolysis reactor comprises:
(ii) the ion-exchange membrane;
(i) the anode, which comprises an anode catalyst layer applied to a first surface of (ii) the ion-exchange membrane; an electrically conductive structure for providing a space for the flow of the electrolytic solution; and a current collector in which a flow path for supplying reactants of the water and metal cations and a flow path for releasing the products are formed; and
(iii) the cathode, which comprises a cathode catalyst layer applied to a second surface of (ii) the ion-exchange membrane; (iv) the gas diffusion layer; and a current collector in which a flow path for supplying reactants of the carbon dioxide and a flow path for releasing the products are formed;
wherein the water which moves from the anode to the cathode through the ion-exchange membrane, the water vapor in the carbon dioxide-containing gas, or both forms a water film on the surface of a cathode catalyst layer;
wherein the cathode catalyst layer has a particulate structure or a porous structure, and the cathode catalyst layer is configured to promote formation of the water film on the surface of the cathode catalyst layer;
wherein the electrolytic solution to be supplied to the anode is the aqueous solution of a Group I metal salt at a concentration of 0.1 M to 2 M; and
wherein the concentration of the carbonate and/or formate recovered from the second gas-liquid separator is regulated by supplying additional water vapor to the cathode according to the concentration of the carbonate and/or formate recovered from the second gas-liquid separator.

US Pat. No. 10,988,846

ELECTRODE ASSEMBLY, ELECTRODE STRUCTURES AND ELECTROLYSERS

INEOS TECHNOLOGIES SA, V...

1. An electrode assembly comprising an anode structure and a cathode structure, each of said anode structure and cathode structure comprisingi) a flange which can interact with a flange on another electrode structure to hold a separator in between the two,
ii) an electrolysis compartment which contains an electrode, and which in use contains a liquid to be electrolysed,
iii) an inlet for the liquid to be electrolysed and
iv) an outlet header for evolved gas and spent liquid,wherein the outlet header on one of the anode structure and the cathode structure is an external outlet header wherein the external outlet header is an outlet volume by which gases evolved during electrolysis exit the electrode structure and which is provided on the electrode structure outside of the electrolysis compartment, and the outlet header on the other one of the anode structure and the cathode structure is an internal outlet header wherein the internal outlet header is an outlet volume by which gases evolved during electrolysis exit the electrode structure and which is provided on the electrode structure inside of the electrolysis compartment, and further where one or both of the outlet headers comprise one or more internal cross members located along part of or all of the length of and attached internally to the sides of the header.

US Pat. No. 10,988,845

PLATED STEEL SHEET HAVING MULTILAYER STRUCTURE AND MANUFACTURING METHOD THEREFOR

POSCO, Pohang-si (KR)

1. A plating steel sheet having a multilayer structure, comprising:a base steel sheet;
a first Zn layer formed on the base steel sheet;
a second Zn—Mg layer formed on the first Zn layer; and
a third Zn layer formed on the second Zn—Mg layer,
wherein the second Zn—Mg layer comprises: one or more of a Zn—Mg amorphous phase and a Zn—Mg alloy phase having a nanocrystalline form.

US Pat. No. 10,988,843

SYSTEM FOR DETERMINING CLEANING PROCESS ENDPOINT

Applied Materials, Inc., ...

1. A system for cleaning a processing chamber comprising:the processing chamber;
a gas source containing a cleaning gas;
an inlet valve in communication with the gas source and the processing chamber to allow a flow of the cleaning gas from the gas source into the processing chamber;
a vacuum pump;
an outlet valve in communication with the processing chamber and the vacuum pump to allow a flow of cleaning gas from the processing chamber;
a pressure sensor; and
a controller, wherein the controller comprises a processing unit and a memory device, wherein the memory device comprises instructions, which when executed by the processing unit, enable the controller to:
monitor a flow rate, or a parameter indicative of the flow rate, of the cleaning gas into or out of the processing chamber during a cleaning process; and
terminate the cleaning process based on changes to the monitored flow rate or the parameter.

US Pat. No. 10,988,841

FILM-FORMING METHOD, MANUFACTURING METHOD OF ELECTRONIC DEVICE, AND MASK HOLDER

THE JAPAN STEEL WORKS, LT...

1. A mask holder capable of holding a mask, comprising:a suspension portion capable of suspending the mask and moving vertically; and
a supporting portion capable of supporting the suspension portion and separating from the suspension portion,
wherein the supporting portion includes:
a front surface; and
a back surface on a side opposite to the front surface,
a first groove formed in the front surface, a second groove communicating with the first groove and having a width smaller than that of the first groove, and a third groove formed in the back surface, communicating with the second groove and having a width smaller than that of the second groove are formed in the supporting portion,
the suspension portion is disposed in the second groove and is configured to be able to come into and out of contact with a bottom surface of the second groove, and
the back surface of the supporting portion is configured to be able to come into and out of contact with the mask.

US Pat. No. 10,988,840

CRYSTAL OSCILLATION PROBE STRUCTURE AND EVAPORATION DEVICE

CHENGDU BOE OPTOELECTRONI...

1. A crystal oscillation probe structure, comprising:a guide cover, comprising a chamber with a guide opening;
a crystal oscillation probe, fixed in the chamber and comprising at least one crystal oscillation sheet;
a mesh screen structure, comprising a plurality of openings, the mesh screen structure being located on a traveling path of a material traveling toward the at least one crystal oscillation sheet and disposed on a side of the at least one crystal oscillation sheet facing the guide opening;
a pedestal, and the at least one crystal oscillation sheet is fixed on a side of the pedestal facing the guiding opening;
wherein at least two crystal oscillation sheets are disposed on the pedestal, a shielding plate is disposed on the pedestal, the shielding plate is located between the crystal oscillation sheet and the guide opening, and
an orthographic projection of one of the crystal oscillation sheets on the pedestal is outside an orthographic projection of the shielding plate on the pedestal, an orthographic projection of remaining crystal oscillation sheets on the pedestal is located within the orthographic projection of the shielding plate on the pedestal; and
an operating lever, wherein one end of the operating lever is connected to the shielding plate, and another end of the operating lever extends to outside of the guide cover.

US Pat. No. 10,988,838

COLOR FILM AND METHOD OF FORMING THE SAME

NATIONAL CHENG KUNG UNIVE...

1. A method of forming a color film, comprising:providing a metal substrate; and
performing a sputtering operation on the metal substrate in a reaction chamber, so as to form a single-layered titanium oxynitride film having a predetermined color over the metal substrate, wherein a back pressure of the reaction chamber is 5×10?6 torr to 8×10?6 torr before the sputtering operation is performed, and the sputtering operation comprises:
bombarding a titanium target with a gas mixture containing a noble gas and a nitrogen gas using a sputtering power of 150 W to 350 W, wherein a volume of the nitrogen gas is 1.5% to 35% of a volume of the gas mixture, and the sputtering operation excludes an operation of introducing oxygen gas.

US Pat. No. 10,988,836

METHOD FOR PRODUCING HIGH-STRENGTH GALVANIZED STEEL SHEET

JFE STEEL CORPORATION, T...

1. A method for producing a high-strength galvanized steel sheet, the method comprising:obtaining a steel sheet having a chemical composition including:
C: 0.3% or less, by mass %,
Si: 0.1 to 2.5%, by mass %,
Mn: 0.5 to 3.0%, by mass %,
P: 0.100% or less, by mass %,
S: 0.0100% or less, by mass %, and
Fe and incidental impurities;
performing oxidation processing on the steel sheet;
after the oxidation processing, performing reduction-annealing on the steel sheet; and
after the reduction-annealing, performing hot-dip galvanizing processing on the steel sheet,
wherein:
the oxidation processing is performed in such a manner that,
in a first stage, the steel sheet is heated at a temperature of 400 to 750° C. in an atmosphere having an O2 concentration of 1000 ppm by volume or more and a H2O concentration of 1000 ppm by volume or more, and,
in a second stage, the steel sheet is heated at a temperature of 600 to 850° C. in an atmosphere having an O2 concentration of less than 1000 ppm by volume and a H2O concentration of 1000 ppm by volume or more, and
the reduction-annealing is performed in such a manner that,
in a heating zone, the steel sheet is heated at a heating rate of 0.1° C./sec or more to a temperature of 650 to 900° C. in an atmosphere having a H2 concentration of 5 to 30 vol % and a H2O concentration of 10 to 600 ppm by volume with a balance of N2 and incidental impurities, and thereafter,
in a soaking zone, the steel sheet is soaked and held for 10 to 300 seconds with a temperature variation in the soaking zone of ±20° C. or less in an atmosphere having a H2 concentration of 5 to 30 vol % and a H2O concentration of 700 to 5000 ppm by volume with a balance of N2 and incidental impurities.

US Pat. No. 10,988,835

HARD PARTICLES AND SINTERED SLIDING MEMBER USING THE SAME

TOYOTA JIDOSHA KABUSHIKI ...

1. A hard particle consisting of: 1% to 7% by mass of La, 30% to 50% by mass of Mo, 10% to 30% by mass of Ni, 10% by mass or less of Mn, 1.0% by mass or less of C, with the balance being unavoidable impurities and Co.

US Pat. No. 10,988,831

PRODUCTION OF METAL MATRIX NANOCOMPOSITES

1. A method for producing metal matrix nanocomposites, the method comprising:obtaining a nanodispersion by dispersing a plurality of nanoparticles into an inert gas within a dispersion chamber, the dispersing the plurality of nanoparticles into the inert gas comprising:
injecting a pressurized stream of the inert gas into the dispersion chamber; and
mechanically mixing the inert gas and the plurality of nanoparticles;
injecting the nanodispersion into an air-tight crucible containing a volume of a molten metal, injecting the nanodispersion into the air-tight crucible comprising injecting the nanodispersion into the volume of the molten metal;
obtaining a molten mixture by mechanically mixing the nanodispersion with the volume of the molten metal; and
applying a casting process on the molten mixture by transferring the molten mixture into a die, wherein the air-tight crucible comprises: a second mixing mechanism disposed within the air-tight crucible, the second mixing mechanism comprising at least one impeller inserted into the volume of the molten metal; and an injection probe inserted within the volume of the molten metal, a tip of the injection probe dipped into the volume of the molten metal positioned immediately above the at least one impeller, wherein mechanically mixing the nanodispersion with the volume of molten metal comprises mixing the nanodispersion with the volume of molten metal by the second mixing mechanism, and wherein injecting the nanodispersion into the volume of the molten metal comprises injecting the nanodispersion into the volume of molten metal immediately above the at least one impeller via the injection probe, wherein the air-tight crucible further comprises: a crucible body comprising an upper opening; a crucible cap; a gas inlet port in fluid communication with an inner volume of the crucible body; and a gas outlet port in fluid communication with an inner volume of the crucible body, wherein injecting the nanodispersion into the air-tight crucible containing the volume of the molten metal further comprises: pouring the volume of the molten metal into the air-tight crucible via the upper opening; sealing the upper opening utilizing the crucible cap; and providing a stream of inert gas within the air-tight crucible by injecting the inert gas into the air-tight crucible via the gas inlet port and discharging the inert gas out of the air-tight crucible via the outlet port.

US Pat. No. 10,988,829

METHOD FOR PRODUCING NICKEL ALLOYS WITH OPTIMIZED STRIP WELDABILITY

VDM Metals International ...


wherein the alloy is smelted openly and cast as ingots,
the ingots are subjected if necessary to at least one heat treatment,
the ingots are then remelted at least one time by electroslag refining,
the remelted ingot obtained in this way is subjected if necessary to at least one heat treatment,
the ingot is subjected to at least one cold and/or hot deformation cycle, until strip material of predeterminable material thickness exists,
the strip material is subdivided into strip sections of defined lengths/widths,
the strip sections are reformed as an open pipe, and
the abutting ends of the open pipe situated opposite one another are joined to one another by longitudinal seam welding for formation of a closed pipe.

US Pat. No. 10,988,828

EXTRACTION OF SCANDIUM VALUES FROM COPPER LEACH SOLUTIONS

Scandium Intrenational Mi...

1. A method for extracting scandium values from an ore feedstock, comprising:providing a feedstock of a copper ore which contains scandium values;
extracting scandium values from the ore with a leaching solution, thereby obtaining a pregnant leachate;
contacting the pregnant leachate with an ion exchange resin, thereby extracting scandium values from the pregnant leachate and forming a loaded extractant;
stripping the scandium values from the loaded extractant with a stripping solution, thereby forming a loaded stripping solution; and
precipitating the scandium values from the loaded stripping solution as a scandium-containing precipitate.

US Pat. No. 10,988,827

COALESCING ELEMENTS IN COPPER PRODUCTION

3M Innovative Properties ...

1. A method of coalescing droplets in an emulsion, the emulsion comprising:a continuous aqueous phase having a pH?5 optionally containing copper ions, and
an organic phase comprising a complex of a lixiviant and copper ions, the method comprising contacting the emulsion with a nonwoven web substrate.

US Pat. No. 10,988,823

ANNEALED STEEL MATERIAL AND METHOD FOR MANUFACTURING THE SAME

DAIDO STEEL CO., LTD., N...

1. An annealed steel material having a composition consisting of, in mass %:0.28?C<0.42,
0.01?Si?1.50,
0.20?Mn?1.20,
4.80?Cr?6.00,
0.80?Mo?3.20,
0.40?V?1.20, and
0.002?N?0.080,
with a balance being Fe and unavoidable impurities, and
optionally,
Cu?1.00,
Ni?1.50,
B?0.0050,
W?5.00,
Co?4.00,
Nb?0.100,
Ta?0.100,
Ti?0.100,
Zr?0.100,
Al?1.50,
S?0.200,
Ca?0.2000,
Se?0.50,
Te?0.100,
Bi?0.50, and
Pb?0.50,
wherein the annealed steel material has:
a cross-sectional size of a thickness of 200 min or more and a width of 250 mm or more; and
a hardness of 100 HRB or less,
wherein, when a cross-section of the annealed steel material is polished, corroded with an acid to expose a metallic structure, and observed with an optical microscope,
a diameter of a largest ferritic gain observed in the metallic structure in a state after annealing is 120 ?m or less in terms of a perfect circle equivalent,
an area ratio of carbides is 3.0% or more and less than 10.5%, in which the area ratio is obtained by an equation of Area ratio (%)=100xs/A from a total area “s” of carbides present in a cumulative area A of plural visual fields observed in 5,000 magnifications, the cumulative area A of the plural visual fields being in a range from 4,000 ?m2 to 5,000 ?m2, and
an average particle diameter of the carbides is 0.18 ?m or more and 0.29 ?m or less, in which when an average area C=s/n is calculated from the total area “s” of the carbides and a total number “n” of the carbides, the average particle diameter of the carbides is a diameter of an assumed perfect circle having an area of C, and
wherein the carbides are spherical carbides uniformly dispersed, and the metallic structure is in the state after the annealing and before quenching.

US Pat. No. 10,988,818

EFFICIENT LONG-SERVICE-LIFE BLOWING METHOD AND SYSTEM FOR VANADIUM EXTRACTION-DECARBURIZATION DUPLEX CONVERTERS

UNIVERSITY OF SCIENCE AND...

1. A method for vanadium extraction from molten iron, comprising:smelting a molten iron in a vanadium extraction converter;
smelting a vanadium-depleted molten iron from the vanadium extraction converter in a decarburization converter;
combustion on combusting a flue gas from the vanadium extraction converter to obtain a first CO2—N2 mixed gas having a first purity;
combusting a flue gas from the decarburization converter to obtain a second CO2—N2 mixed gas having a second purity;
combusting a flue gas from the decarburization converter flue gas to obtain an O2—CO2—N2 mixed gas;
purifying a first portion of the second CO2—N2 mixed gas in a purification device to obtain a CO2 gas;
bottom blowing the vanadium extraction converter with the first CO2—N2 mixed gas;
blowing iron ore powder into the vanadium extraction converter with a second portion of the second CO2—N2 mixed gas; and
bottom blowing the decarburization converter and/or bottom injecting lime powder into the decarburization converter with a mixture of a third portion of the second CO2—N2 mixed gas, the O2—CO2—N2 mixed gas, and the CO2 gas.

US Pat. No. 10,988,798

DDAO COMPOUNDS AS FLUORESCENT REFERENCE STANDARDS

Life Technologies Corpora...

1. A multiplex assay technique comprising(a) combining in a mixture:
at least two different targets,
at least two probes each comprising a target-specific moiety, a reporter dye, and a quencher dye, wherein each target-specific moiety is an oligonucleotide and is specific for a different target and each reporter dye is different from the other reporter dyes and is different from the reference dye, and
a reference dye having a structure according to formula (I):

wherein:
each of R1 to R3 and R6 to R8 is independently —H, halogen, —CO2H, —CO2R, —SO3H, —SO3R, —CH2CO2H, —CH2CO2R, —CH2SO3H, —CH2SO3R, —CH2NH2, —CH2NHR, —NO2, C1-C6 alkyl, substituted C1-C6 alkyl, C1-C6 alkoxy, and substituted C1-C6 alkoxy, wherein R is C1-C6 alkyl, substituted C1-C6 alkyl, C1-C6 alkoxy, and substituted C1-C6 alkoxy;
R4 and R5 taken separately are selected from C1-C6 alkyl, and C1-C6 substituted alkyl, or R4 and R5 taken together are selected from C3-C7 cycloalkyl, C4-C7 unsaturated cycloalkyl, C3-C7 substituted cycloalkyl, or C4-C7 substituted unsaturated cycloalkyl;
(b) amplifying the mixture of (a) to form an amplified mixture;
(c) irradiating the mixture with a first excitation wave length; and
(d) detecting the radiation emitted by the at least two reporter dyes, which can each be measured in the presence of the other reporter dyes and the reference dye;
wherein the assay indicates the presence, absence, amount, and/or identity of the at least two different targets in the mixture.

US Pat. No. 10,988,793

CLOUD MANAGEMENT WITH POWER MANAGEMENT SUPPORT

Red Hat, Inc., Raleigh, ...

1. A method comprising:receiving a request to instantiate a virtual machine, wherein the request specifies a task to be completed by the virtual machine;
selecting, by a processor, a computing system from a plurality of computing systems where the virtual machine is to be instantiated based upon the task to be completed;
determining, by the processor and based on the task to be completed by the virtual machine, whether a power state is to be altered to instantiate the virtual machine on the computing system;
in response to determining that the power state is to be altered, identifying a power alteration protocol corresponding to the task to be completed by the virtual machine; and
altering the power state of the computing system, in view of the identified power alteration protocol.

US Pat. No. 10,988,767

INHIBITION OF OXIDATIVE STRESS IN ATRIAL FIBRILLATION

Northwestern University, ...

1. A method of inhibiting oxidative stress in a subject suffering from heart arrhythmia comprising administering directly into myocardial tissue of the subject an effective amount of a nucleic acid inhibitor of NADPH oxidase 2 (NOX2) gene expression, wherein said administering is under conditions such that NOX2 gene expression is reduced and a level of oxidative stress in the myocardial tissue of the subject is reduced or eliminated.

US Pat. No. 10,988,762

REVERSE TRANSCRIPTASES AND USES THEREOF

Bio-Rad Laboratories, Inc...

1. A hybrid reverse transcriptase comprising a finger domain, a palm domain, a thumb domain, a connection domain and an RNase H domain, the hybrid reverse transcriptase comprising:a portion of mouse leukemia virus reverse transcriptase (MLVRT) comprising the finger domain and the palm domain, wherein the portion of the MLVRT is at least 95% identical to SEQ ID NO:1, said portion of the MLVRT linked to
a portion of feline leukemia virus reverse transcriptase (FLVRT) comprising the thumb domain, the connection domain, and the RNase H domain, wherein the portion of the FLVRT is at least 95% identical to SEQ ID NO:5.

US Pat. No. 10,988,760

SAMPLE PREPARATION ON A SOLID SUPPORT

ILLUMINA CAMBRIDGE LIMITE...

1. A solid support having transposome complexes immobilized thereon,wherein each transposome complex comprises a homodimer of a transposase non-covalently bound to a first polynucleotide of a double-stranded nucleic acid comprising the first polynucleotide and a second polynucleotide,
wherein the first polynucleotide comprises:
(i) a 3? portion comprising a transposon end sequence, and
(ii) a first tag comprising a tag domain;
wherein the second polynucleotide comprises a region complementary to the transposon end sequence;
wherein the transposome complexes comprise a first subset of homodimers, the first subset comprising a first sequence of the first polynucleotide, and a second subset of homodimers, the second subset comprising a second sequence of the first polynucleotide, wherein the second sequence is different than the first sequence; and
the transposome complexes are bound to an immobilized oligonucleotide.

US Pat. No. 10,988,757

MAGNETIC NANOSTRUCTURE FOR DETECTING AND ISOLATING CELL-FREE DNA COMPRISING CATIONIC POLYMER AND MAGNETIC-NANOPARTICLE-CONTAINING CONDUCTIVE POLYMER

GENOPSY CO., LTD., Seoul...

1. A magnetic nanowire for detecting and isolating cell-free DNA (cfDNA),wherein the magnetic nanowire comprises polypyrrole in which iron oxide nanoparticles and biotin are incorporated,
the magnetic nanowire is surface-treated with polyethyleneimine containing biotin, wherein the polyethyleneimine is conjugated onto the surface of the magnetic nanowire via a biotin-streptavidin-biotin interaction, and
the magnetic nanowire is prepared by electrochemical deposition.

US Pat. No. 10,988,756

MICROCHIP

NEC CORPORATION, Tokyo (...

1. A microchip, comprising:a DNA analysis part configured to analyze DNA, which comprises at least a cell lysis chamber for cell lysis and a DNA extraction chamber which is connected to the cell lysis chamber and configured to extract DNA from lysed cells,
a DNA preservation part which comprises a solution absorptive medium which absorbs a partial portion of a DNA sample, and
a flow path communicating the DNA analysis part with the DNA preservation part, wherein the flow path comprises a branch part which branches off into multiple branches, and opening end parts of the branch part respectively contact with different regions on the solution absorptive medium.

US Pat. No. 10,988,743

CORYNEFORM BACTERIAL TRANSFORMANT AND METHOD FOR PRODUCING 4-AMINOBENZOIC ACID OR SALT THEREOF USING SAME

RESEARCH INSTITUTE OF INN...

1. A transformant having 4-aminobenzoic acid producing ability, the transformant being obtained by introducing a gene that encodes a two-component enzyme having para-aminobenzoate synthase component I activity and para-aminobenzoate synthase component II activity, which is a gene pabAB, and a gene that encodes an enzyme having 4-amino-4-deoxy chorismate lyase activity, which is a gene pabC, into Corynebacterium glutamicum as a host,wherein the pabAB is a gene of Corynebacterium callunae, Corynebacterium efficiens, or Corynebacterium casei, and
wherein the pabC is a gene of Escherichia coli, Escherichia fergusonii, Saccharophagus degradans, Arthrobacter phenanthrenivorans, Anabaena variabilis, Azotobacter vinelandii, Ochrobactrum anthropi, Xenorhabdus bovienii, Bacillus pseudofirmus, Caulobacter crescentus, Synechococcus sp., Bacteroides thetaiotaomicron, or Ferrimonas balearica.

US Pat. No. 10,988,734

METHODS FOR PREPARING THERAPEUTICALLY ACTIVE CELLS USING MICROFLUIDICS

GPB Scientific, Inc., Ri...

1. A method for preparing cells for treating a patient with cancer, comprising the steps:a) purifying T cells from an apheresis sample from said patient, wherein the sample comprises leukocytes and platelets, wherein the leukocytes comprise T cells and wherein the T cells are purified by:
i) performing a size based separation using a microfluidic device to produce an enriched product in which, compared to the sample, the ratio of platelets to T cells has been reduced by at least 70%; and wherein the microfluidic device comprises:
at least one channel extending from a sample inlet to one or more fluid outlets, wherein the channel is bounded by a first wall and a second wall opposite from the first wall;
an array of obstacles disposed in the channel in a manner such that, when the sample is applied to an inlet of the device and fluidically passed through the channel, T cells flow to one or more collection outlets to form an enriched product, and platelets flow to one more waste outlets that are separate from the collection outlets;
ii) in addition to the size based separation, performing an affinity based separation by binding T cells to a carrier that binds to T cells with specificity, and then separating the carrier-bound T cells from cells not bound to carrier;
b) after the purification of step a), activating and expanding the T cells to produce a composition in which the percentage of T cells that are central memory T cells has increased compared to the percentage of T cells that are central memory T cells in the sample; and in which the percentage of T cells that are central memory T-cells is greater than in a method in which the sample is not purified by a size based separation using a microfluidic device to reduce the ratio of platelets to T-cells prior to activation and expansion;
c) after the purification of step a), genetically engineering activated T cells to comprise modified cell surface receptors of therapeutic benefit in the treatment of said patient's cancer;wherein the T cells in the sample are not centrifuged during the method.

US Pat. No. 10,988,726

SYSTEMS AND METHODS FOR AUTOMATED CELL CULTURING

CYTERA CELLWORKS LIMITED,...

1. An apparatus, comprising:a housing defining a receiving portion;
a tray assembly including a tray, a first container coupled to the tray, and a second container coupled to the tray, the tray assembly configured to be removably received within the receiving portion of the housing;
a multiport valve coupled to the first container and the second container, the multiport valve including a master port and a plurality of selectable ports;
a pump actuator coupled to the housing and configured to be operatively coupled to a fluid pump, the fluid pump configured to be coupled to the master port of the multiport valve;
a valve actuator coupled to the housing and configured to be coupled to the multiport valve when the tray assembly is coupled to the receiving portion of the housing, the valve actuator and the pump actuator collectively configured to selectively move a fluid into and out of the first container and into and out of the second container when the tray assembly is received within the receiving portion of the housing; and
an agitator coupled to the housing and configured to engage the tray assembly when the tray assembly is received within the receiving portion of the housing, the agitator configured to agitate the tray assembly including the first container and the second container.

US Pat. No. 10,988,725

PERFUSION FILTRATION SYSTEMS

Artemis Biosystems, Inc.,...

1. A method of filtering a cell culture media comprising passing a cell culture media comprising mammalian cells at a viable cell density of at least 10×106 cells per mL and a virus through a plurality of tubular porous membranes of a filter element enclosed within a casing,wherein each tubular porous membrane filter element comprises a plurality of tubular porous membranes, wherein at least 95% of the pores in each of the plurality of tubular porous membranes are between 5 ?m and 15 ?m in size and wherein the internal diameter of each of the plurality of tubular porous membranes is between about 1 mm to about 10 mm,
wherein the mammalian cells are retained within the tubular porous membranes and a permeate comprising the virus flows through the pores of the tubular porous membranes into the casing.

US Pat. No. 10,988,723

MODULAR ASSEMBLIES AND SYSTEMS FOR CELL CULTURES AND METHODS THEREOF

20. A modular assembly comprising:a transferrable cell culture insert, comprising:
a handling layer having a non-porous outer portion;
an aperture disposed within the handling layer;
a porous rim disposed around a periphery of the aperture; and
a cell culture membrane disposed within the aperture and tethered to the rim;
a top housing comprising a first access port;
a bottom housing, wherein the top and bottom housing are configured to accommodate the transferrable cell culture insert and to be reversibly attached to one another;
a fluidics layer comprising a first channel and a first via that is in fluidic communication with the first access port and the first channel, wherein the fluidics layer is disposed between the top housing and the transferable cell culture insert;
a top sealing layer disposed between the fluidics layer and the transferrable cell culture insert, wherein the top sealing layer comprises a second channel that is in fluidic communication with a top surface of the cell culture membrane and with the first channel of the fluidics layer; and
a bottom sealing layer disposed between the transferrable insert and the bottom housing.

US Pat. No. 10,988,722

PERFUSION MANIFOLD ASSEMBLY

EMULATE, Inc., Boston, M...

1. A system, comprising:a) a perfusion manifold assembly, comprising i) one or more fluid reservoirs, ii) a fluidic backplane positioned under, and in fluidic communication with, said fluid reservoirs, said fluidic backplane comprising fluid channels that terminate at fluid outlet ports, and iii) a skirt having a guide mechanism; and
b) a microfluidic device positioned in a carrier, said carrier detachably engaging said guide mechanism of said skirt, said microfluidic device comprising i) microchannels in fluidic communication with said perfusion manifold assembly via ii) one or more inlet ports on a iii) mating surface, wherein said one or more fluid inlet ports of said microfluidic device are positioned against said one or more fluid outlet ports of said skirt of said perfusion manifold assembly under conditions such that fluid flows from said fluid reservoirs of said perfusion manifold assembly through said one or more fluid outlet ports into said one or more fluid inlet ports of said microfluidic device.

US Pat. No. 10,988,721

CONTROLLING PRESSURE

EMULATE, Inc., Boston, M...

1. A method of controlling pressure while perfusing cells, comprising: A) providing a) a plurality of microfluidic devices, each of said microfluidic devices comprising i) one or more microchannels comprising living cells and ii) one or more reservoirs comprising culture media, b) one or more pressure actuators, B) coupling said pressure actuators to at least one of the said reservoirs, the coupling adapted such that actuated pressure modulates the perfusion of at least some of said living cells, C) turning said one or more pressure actuators between two or more pressure setpoints, thereby controlling pressure while perfusing said cells.

US Pat. No. 10,988,720

PEEL PLATE ASSEMBLY

Charm Sciences, Inc., La...

1. A peel plate assembly comprising:a. a semi-rigid plate having a recessed well that is sunken below an upper face, wherein a bottom wall of the recessed well on a lower horizontal plane below said upper face, a pair of proximate extensions extending radially and being offset from said lower horizontal plane of said recessed well and independent of said recessed well, and wherein each of said proximate extensions having a tab adjacent said upper face and protruding from said proximate extensions, and at least one raised platform protruding from said upper face and on an upper horizontal plane spaced offset from said lower horizontal plane of said recessed well and independent of said adjacent recessed well;
b. a removable cover seal having a perimeter and aligned between said protruding proximate extensions and said protruding raised platform, thereby removably enclosing said recessed well; and
c. an adhesive aligned between said pair of proximate extensions and between said removable cover seal and said upper face, and wherein said adhesive provides a moisture vapor barrier along said perimeter around said recessed well in an enclosed position and less than one pound peel adhesion.

US Pat. No. 10,988,713

COMPOSITION CONTAINING PEPTIDASE AND BIOSURFACTANT

Evonik Operations GmbH, ...

1. A composition comprisingA) from 0.1 wt % to 3 wt % of a peptidase selected from the group consisting of the trypsins and chymotrypsin proteases of EC 3.4.21.1, EC 3.4.21.2, and EC 3.4.21.4,
B) from 5 wt % to 30 wt % of a biosurfactant rhamnolipids wherein rhamnolipid is a compound of Formula (I) or salts thereof

wherein
m=2, 1 or 0
n=1 or 0,
R1 and R2 are organic residues having 2 to 24 carbon atoms,
C) from 2 wt % to 30 wt % of an anionic surfactant having the properties at pH of 7 and 20° C., at least 90 mol % of the anionic surfactant molecules have at least one negatively charged group and no isoelectric point of pHIEP?2-12 at 25° C., and
D) from 10 wt % to 95 wt % of water.

US Pat. No. 10,988,712

WATER MINERAL CLEANING SOLUTIONS AND RELATED METHODS

1. A cleaning composition comprising:at least one of sodium lauryl sulfate, hydrochloric acid, muriatic acid, hydrobromic acid, or hydroiodic acid;
benzalkonium chloride;
one of coco betaine or cocamidopropyl betaine;
iodized salt;
sodium sulfonate; and
potassium nitrate.

US Pat. No. 10,988,710

ANIONIC SURFACTANTS AND DETERGENTS COMPRISING THEM

Studiengesellschaft Kohle...

1. An anionic surfactant of general formula (I),in which R? denotes a linear or branched alkyl functional group having 6 to 20 carbon atoms, R2 and R3, independently of one another, denote H or H3CO, and M denotes hydrogen, an alkali metal or an N+R4R5R6 grouping, in which R4, R5 and R6, independently of one another, denote hydrogen, an alkyl group having 1 to 6 carbon atoms or a hydroxyalkyl group having 2 to 6 carbon atoms.

US Pat. No. 10,988,708

SYSTEMS AND METHODS FOR FATTY ACID ALKYL ESTER PRODUCTION WITH RECYCLING

Inventure Renewables, Inc...

1. A method or an industrial process for producing a fatty acid alkyl ester from a natural oil feedstock and/or a mixed lipid feedstock,wherein the natural oil feedstock and/or mixed lipid feedstock comprises 0% to 100% un-esterified organic acid by weight of the feedstock,
the method or industrial process comprising:
(a) producing a plurality of fatty acid alkyl esters using an alcoholysis reaction,
wherein the alcoholysis reaction takes place under conditions comprising:
(i) feeding or adding the natural oil feedstock and/or mixed lipid feedstock having no catalyst and at least one alcohol into an alcoholysis reactor or equivalent, thus making a reaction mixture of the natural oil feedstock and/or mixed lipid feedstock into the alcoholysis reactor or equivalent;
(ii) reacting the reaction mixture at a temperature of between about 100° C. to 500° C. and pressure of between about 1 bar to about 355 bar,
thereby producing the plurality of crude fatty acid alkyl esters, wherein optionally the plurality of crude fatty acid alkyl esters have an acid value of less than about 10;
(b) separating the crude fatty acid alkyl ester from at least one alcohol and/or water, either inside or outside the alcoholysis reactor,
(c) purifying the crude fatty acid alkyl ester by a process comprising generating a first fatty acid alkyl ester and at least a first residual lipid phase; and
(d) recycling of at least a portion of the first residual lipid phase back to the alcoholysis reactor or equivalent for alcoholysis so as to increase the overall yield of fatty acid alkyl ester.

US Pat. No. 10,988,707

METHOD FOR THERMAL TREATMENT OF TALL OIL PITCH (TOP)

1. Method for the treatment of tall oil pitch (TOP), said method comprising:heating the TOP in a reactor to a temperature of at least 300° C.;
cracking high molecular weight components in the TOP while maintaining the temperature in the reactor at 300° C. or higher under a period of time sufficient to enable said cracking, generating fatty acids and/or rosin acids, and/or derivatives thereof, and/or unsaponifiables and/or their derivatives, which have lower molecular weight compared to the high molecular weight components in the original TOP, thereby yielding a modified TOP phase having lower viscosity compared to the original TOP.

US Pat. No. 10,988,705

REMEDIATION OF PESTICIDES FROM AGRICULTURAL OILS

APTIA ENGINEERING LLC, G...

1. A method of remediating pesticides from an agricultural oil, comprising:mixing a reaction solvent, a reducing agent, and an agricultural oil into a reaction mixture in a reaction vessel;
controlling the temperature of the reaction mixture;
producing a pre-neutralization mixture including a separation solvent;
transferring the pre-neutralization mixture into a neutralization reactor that contains a neutralization agent;
mixing the pre-neutralization mixture with the neutralization agent and allowing separation into an aqueous layer and a separation solvent layer;
draining the aqueous layer; and
distilling the separation solvent in the separation solvent layer from the remediated agricultural oils.

US Pat. No. 10,988,701

LUBRICATING COMPOSITION CONTAINING AN OXYALKYLATED HYDROCARBYL PHENOL

The Lubrizol Corporation,...

1. A lubricating composition comprising:(i) an oil of lubricating viscosity,
(ii) 0.1 to 1.5 wt % of an oxyalkylated hydrocarbyl phenol, wherein the oxyalkylated hydrocarbyl phenol is free of aromatic hydrocarbyl groups,wherein the oxyalkylated hydrocarbyl phenol is represented by formula:wherein each R2 is independently hydrogen or a hydrocarbyl group of 1 carbon atom;R3 is hydrogen,R4 is a polyisobutenyl group having a number average molecular weight of 750 to 1,100; andn=3 to 8; and(iii) 0.15 wt % to less than 3 wt % of an overbased calcium sulphonate detergent,
wherein the lubricating composition has a total phosphorus content of from 100 ppm to 600 ppm all delivered from zinc dialkyldithiophosphate.

US Pat. No. 10,988,700

DESULFURIZATION SYSTEM USING CATALYST FOR DESULFURIZATION

LOWCARBON CO., LTD, Jeol...

1. A desulfurization system using a catalyst for desulfurization, comprising:a coal feed unit for conveying a combustible substance;
a spray unit for spraying a catalyst for desulfurization;
a coal pulverization unit for pulverizing the combustible substance conveyed from the coal feed unit; and
a combustion unit for combusting the pulverized combustible substance,
wherein during transfer of the combustible substance from the coal feed unit to the coal pulverization unit, the catalyst for desulfurization is sprayed using the spray unit and is mixed with the combustible substance,
wherein the catalyst for desulfurization includes a liquid catalyst for desulfurization or a powder catalyst for desulfurization,
wherein the spray unit sprays the liquid catalyst for desulfurization at a spray pressure of 3 to 10 kg/cm2 and an angle of 45 to 68° toward the combustible substance dropping in a rightward(90°) direction,
the spray unit sprays the powder catalyst for desulfurization at a spray pressure of 3 to 5 kg/cm2 and an angle of 0 to 25° toward the combustible substance dropping in a rightward(90°) direction; and
wherein the powder catalyst for desulfurization is fed to a screw conveyor to quantify an amount thereof before being supplied into the spray unit.

US Pat. No. 10,988,699

PLASMA GASIFICATION REACTOR AND METHOD

1. A reactor (1) comprising at least one temperature unit (20) which provides high temperature, at least one waste inlet (11) where fuels and/or wastes are fed to the reactor (1), at least one reactant inlet (13 and/or 14 and/or 17), at least one melt outlet (15) which provides an output for a melt formed by inorganic substances coming from heating fuels and/or wastes; the reactor further comprising:a high temperature region (12) configured to be heated to at least 1200° C. by the temperature unit (20) and where endothermic reactions are realized;
a primary and secondary reactant inlet equipment (13 and/or 14 and/or 17) where gassing reactants are fed for production of high energy gas mixture and moreover which can be guided to the high temperature region inlet, the high temperature region, and a high temperature region outlet from changeable different points comprising gas feeding nozzles with variable feeding location and variable angle for controlling reactions;
a U-shaped body which provides prevention of gassing before the fuels and/or wastes enter into the high temperature region (12) which enters into the reactor (1) where the reactant inlets (13 and/or 14 and/or 17) are turned into flexible feeding;
wherein:
the first end of said U-shaped body is fuel and/or waste inlet (11) and the second end thereof is gas outlet (16) and said high temperature region (12) is provided at the horizontal part between the two ends and thus, the entry of the fuels and/or wastes, which enter into the reactor (1), into the high temperature region (12) is made obligatory because of this form of the body (10),
said gas outlet (16) is positioned at a level which is higher than the level of said waste inlet (11), such that a pressure difference is formed as a result of the reaction from the waste inlet (11) towards the direction which is reverse to the direction where fuels and/or waste enter, the high temperature gases which are to leave the reactor (1) pass through the high temperature region (12) and are guided to the gas outlet (16) and exit the reactor (1).

US Pat. No. 10,988,695

PROCESS AND SYSTEM FOR SOLVENT ADDITION TO BITUMEN FROTH

FORT HILLS ENERGY L.P., ...

1. A solvent treatment process for treating a high viscosity bitumen-containing stream, comprising:contacting the high viscosity bitumen-containing stream with a solvent-containing stream having a lower viscosity in a pipeline section comprising interior pipe walls, such that the solvent-containing stream flows downstream along the interior pipe walls prior to mixing between the high viscosity bitumen-containing stream with the solvent-containing stream;
mixing the high viscosity bitumen-containing stream with the solvent-containing stream sufficiently downstream of the pipeline section to produce a mixed in-line flow of a solvent diluted material;
supplying the solvent diluted material into a separation vessel; and
withdrawing from the separation vessel a high diluted bitumen component and a solvent diluted tailings component.

US Pat. No. 10,988,692

LIQUID CRYSTAL MEDIUM AND LIQUID CRYSTAL DEVICE

Merck Patent GmbH, Darms...

1. Medium comprising at least 60% of two or more compounds of formula I
wherein
R11 and R12 are each independently H, F, Cl, CN, NCS or a straight-chain or branched alkyl group with 1 to 25 C atoms, which may be unsubstituted, mono- or polysubstituted by halogen or CN, where one or more non-adjacent CH2 groups may to be replaced, in each occurrence independently from one another, by —O—, —S—, —NH—, —N(CH3)—, —CO—, —COO—, —OCO—, —O—CO—O—, —S—CO—, —CO—S—, —CH?CH—, —CH?CF—, —CF?CF— or —C?C— in such a manner that oxygen atoms are not linked directly to one another,
at least one of
R11 and R12 is an alkyl group, i.e. a straight-chain or branched alkyl group with 1 to 25 C atoms, which may be unsubstituted, mono- or polysubstituted by halogen or CN, where one or more non-adjacent CH2 groups may be replaced, in each occurrence independently from one another, by —O—, —S—, —NH—, —N(CH3)—, —CO—, —COO—, —OCO—, —O—CO—O—, —S—CO—, —CO—S—, —CH?CH—, —CH?CF—, —CF?CF— or —C?C— in such a manner that oxygen atoms are not linked directly to one another in which one CH2 groups is replaced by —CH?CH—, —CH?CF—, —CF?CF—, but from which OCF3 and CF3, are excluded,
MG11 and MG12 are each independently a mesogenic group, wherein at least one of MG11 and MG12 comprises one, two or more 5-atomic and/or 6-atomic rings, in case of comprising two or more 5- and/or 6-atomic rings at least two of these may be linked by a 2-atomic linking group,
Sp1 is a spacer group comprising 1, 3 or 5 to 40 C atoms, wherein one or more non-adjacent and non-terminal CH2 groups may also be replaced by —O—, —S—, —NH—, —N(CH3)—, —CO—, —O—CO—, —S—CO—, —O—COO—, —CO—S—, —CO—O—, —CH(halogen)-, —CH(CN)—, —CH?CH— or —C?—, however in such a way that no two O-atoms are adjacent to one another, no two —CH?CH— groups are adjacent to each other and no two groups selected from —O—CO—, —S—CO—, —O—COO—, —CO—S—, —CO—O— and —CH?CH— are adjacent to each other, and
X11 and X12 are independently from one another a linking group selected from —CO—O—, —O—CO—, —O—, —CH?CH—, —C?C—, —CF2—O—, —O—CF2—, —CF2—CF2, —CH2—O—, —O—CH2—, —CO—S—, —S—CO—, —CS—S—, —S—, and a single bond, under the condition that in —X11-Sp1-X12— no two O atoms are adjacent to one another, no two —CH?CH— groups are adjacent to each other and no two groups selected from —O—CO—, —S—CO—, —O—COO—, —CO—S—, —CO—O— and —CH?CH— are adjacent to each other.

US Pat. No. 10,988,690

MOBILE CHARCOAL/BIOCHAR PRODUCTION AND PELLETIZER SYSTEM AND METHOD THEREOF

1. A method of continuously producing charcoal from a portable burn system, the method comprising the steps of:initiating a combustion process of biomass within a burn compartment;
directing a stream of air from a source of air to at least one compartment of the portable burn system;
burning the biomass inside the burn compartment to produce an amount of charcoal;
transferring the amount of charcoal from the burn compartment to an extruding compartment through a collection compartment, wherein at least a portion of the charcoal is transferred through a portion of a bottom of the burn compartment to the collection compartment in which the bottom of the burn compartment is perforated; and
quenching and extruding the charcoal in the extruding compartment.

US Pat. No. 10,988,689

CORROSION INHIBITOR COMPOSITIONS AND METHODS OF USING SAME

ChampionX USA Inc., Suga...

1. A sulfur-functional tall oil composition comprising a product formed by combining a tall oil fatty amide with 2 mercaptoethanol in a molar ratio of 10:1 to about 1:1 amide to sulfur, and heating the combination in the absence of solvent to a temperature of about 60° C. to 150° C. for a period of about 1 minute to 12 hours; wherein the tall oil fatty amide has the structure R—C(O)NH—R? wherein R is a tall oil fatty group and R? is a group including 1 to 4 carbon atoms.

US Pat. No. 10,988,686

LUMINESCENT PARTICLES COMPRISING ENCAPSULATED NANOPARTICLES AND USES THEREOF

NEXDOT, Romainville (FR)...

1. A luminescent particle (1) comprising a first material (11),wherein the luminescent particle (1) comprises a plurality of particles (2) comprising a second material (21) and at least one nanoparticle (3) dispersed in said second material (21); wherein the first material (11) and the second material (21) have a bandgap superior or equal to 3 eV, and wherein the plurality of particles (2) is uniformly dispersed in the first material (11).

US Pat. No. 10,988,683

PROPPANT TREATMENTS FOR MITIGATING EROSION OF EQUIPMENT IN SUBTERRANEAN FRACTURING OPERATIONS

Halliburton Energy Sendee...

1. A method comprising:conveying a plurality of proppant particulates into a blender at a job site;
while conveying the plurality of proppant particulates into the blender, contacting a plurality of proppant particulates with an aqueous liquid concentrate comprising a hydratable polymer to at least partially coat one or more of the proppant particulates with the hydratable polymer, thereby forming coated proppant particulates;
blending the plurality of proppant particulates comprising the coated proppant particulates with an aqueous base fluid in the blender to form a treatment fluid, the treatment fluid having a viscosity of about 25 cP or less; and
introducing the treatment fluid from the blender into at least a portion of a subterranean formation that includes at least one fracture,
such that the coated proppant particulates are formed on-the-fly during the conveying and immediately utilized to form the treatment fluid in the blending step.

US Pat. No. 10,988,680

CARBON CERAMIC COMPOSITES AND METHODS

DYNAMIC MATERIAL SYSTEMS ...

1. A ceramic composite article comprises:coal dust;
a polymer derived ceramic, wherein the coal dust is mixed with the polymer derived ceramic prior to pyrolyzation of the coal dust and the polymer derived ceramic to form a mixture of coal dust and the polymer derived ceramic;
prior to pyrolyzation of the mixture of coal dust and the polymer derived ceramic, the mixture of coal dust and the polymer derived ceramic is subjected to pressure to form a green composite article; and
the green composite article is pyrolyzed in a non-oxidizing atmosphere, such that at least some of the components of the coal dust are chemically reactive forming chemical bonds with the polymer derived ceramic material during the process of pyrolyzation, and the density of the green composite article increases during pyrolyzation.

US Pat. No. 10,988,679

METHOD FOR PROPAGATING FRACTURES IN SUBTERRANEAN FORMATIONS USING STRESS TREATMENT CYCLES

Halliburton Energy Servic...

1. A method for fracturing and stimulating a subterranean formation, comprising:pumping a micro-proppant slurry into a wellbore located in the subterranean formation, wherein the micro-proppant slurry comprises a fracturing fluid and a micro-proppant having an average particle size of 150 micrometers (?m) or less, and wherein the subterranean formation comprises near field primary fractures and far field secondary fractures; and
sequentially increasing and decreasing flow rates of the micro-proppant slurry into the formation in two or more stress treatment cycles to cycle expansion and contraction of the subterranean formation and increase the likelihood of failure in the subterranean formation due to fatigue and propagate the far field secondary fractures within the subterranean formation, wherein each treatment cycle comprises flowing the micro-proppant into the secondary fractures when increasing the flow rate of the slurry and the propping the secondary fractures open with the micro-proppant when decreasing the flow rate of the micro-proppant slurry.

US Pat. No. 10,988,678

WELL TREATMENT OPERATIONS USING DIVERTING SYSTEM

Baker Hughes, a GE compan...

1. A method of stimulating a subterranean formation penetrated by a well comprising:(A) introducing into the well a fluid comprising particulates of (i) or both (i) and (ii), wherein (i) is a compound of formula (I):
or an anhydride thereof and (ii) is at least one aliphatic polyester having repeating units (II):wherein:R1 is —COO—(R5O)y—R4 or —H;
R2 and R3 are selected from the group consisting of —H and —COO—(R5O)y—R4;
provided both R2 and R3 are —COO—(R5O)y—R4 when R1 is —H and further provided only one of R2 or R3 is —COO—(R5O)y—R4 when R1 is —COO—(R5O)y—R4;
R4 is —H or a C1-C6 alkyl group;
R5 is a C1-C6 alkylene group;
each y is 0 to 5;
n is an integer between 75 and 10,000; and
R is selected from the group consisting of hydrogen, alkyl, aryl, alkylaryl, acetyl, heteroatoms and mixtures thereof;the particulates having a sized distribution to form bridging solids on a face of a first permeability zone of the formation and block the penetration of the fluid into the first permeability zone of the formation;(B) forming a filter cake consisting essentially of the particulates on the face of the first permeability zone and increasing resistance to flow of the well treatment fluid through the first permeability zone by a pressure drop through the filter cake; and
(C) diverting flow of the fluid to a second zone of the formation, the second zone having a permeability lower than the permeability of the first permeability zone.

US Pat. No. 10,988,677

MICRO-AGGREGATES AND MICROPARTICULATES FOR USE IN SUBTERRANEAN FORMATION OPERATIONS

Halliburton Energy Servic...

1. A method comprising:(a) introducing a first treatment fluid into a subterranean formation at a pressure above a fracture gradient of the subterranean formation to create or enhance at least one dominate fracture, wherein the first treatment fluid comprises a first polar base fluid and a first flocculation polymer;
(b) introducing a second treatment fluid into the subterranean formation at a pressure above a fracture gradient to create or enhance at least one branch fracture extending from the at least one dominate fracture, wherein the second treatment fluid comprises a second polar base fluid, a second flocculation polymer, and first microparticulates;
(c) flocculating the first microparticulates with a flocculation polymer selected from the group consisting of the first flocculation polymer, the second flocculation polymer, and any combination thereof to form micro-aggregates;
(d) placing the micro-aggregates in the at least one branch fracture, thereby forming a partial monolayer therein;
(e) introducing a third treatment fluid into the subterranean formation at a pressure above the fracture gradient, wherein the third treatment fluid comprises a third polar base fluid, a third flocculation polymer, and a de-aggregating agent; and
(f) closing the facture, wherein during fracture closure a second microparticulates leaks off into the at least one branch fracture.

US Pat. No. 10,988,675

METHOD TO HYDRAULICALLY FRACTURE A WELL

Multi-Chem Group, LLC, H...

1. A method comprising:providing a fracturing fluid having a viscosity requirement measuring at least one of a conductivity or a density of a water source and measuring at least one of a temperature or a viscosity of the water source;
correlating at least one of the conductivity or the density of a water source to a total dissolved solids (TDS) concentration of the water source;
correlating the TDS concentration of the water source to an ion concentration of the water source; and
selecting at least one species and concentration of friction reducing polymer based at least in part on the fracturing fluid viscosity requirement and at least one of the ion concentration, the temperature, or the viscosity of the water source; and
preparing a fracturing fluid comprising an aqueous base fluid and the at least one species and concentration of friction reducing polymer.

US Pat. No. 10,988,674

CHELATING ETCHING AGENT STIMULATION AND PROPPANT STABILIZATION OF LOW-PERMEABILITY SUBTERRANEAN FORMATIONS

Halliburton Energy Servic...

1. A method comprising:(a) introducing a first treatment fluid into a low-permeability subterranean formation comprising carbonate material having a first fracture network at a first treatment interval therein,
wherein the first treatment fluid comprises a first aqueous base fluid, a chelating etching agent and a surface modification agent wherein the surface modification agent is capable of adhering at least a portion of the chelating etching agent to the surface modification agent coated on the face of the first fracture network,
wherein the chelating etching agent comprises N-(phosphonomethyl)iminodiacetic acid or a salt of N-(phosphonomethyl)iminodiacetic acid, and
wherein the first fracture network comprises a first main fracture and a first microfracture;
(b) placing the chelating etching agent in the first fracture network;
(c) reacting the chelating etching agent with the carbonate material in the first fracture network, wherein the reacting removes the carbonate material, thereby creating at least one conductive channel on a face of the first fracture network;
(d) introducing a second treatment fluid into the low-permeability subterranean formation after the chelating etching agent has reacted with the carbonate material, the second treatment fluid comprising a second aqueous base fluid and micro-sized proppant particulates, wherein the micro-sized proppant particulates have an average particle size distribution of about 0.1 ?m to about 50 ?m; and
(e) placing the micro-sized proppant particulates into the first fracture network to form a partial monolayer in the first microfracture after reacting the chelating etching agent with the carbonate material in the first fracture network.

US Pat. No. 10,988,673

POLYMER FLOODING PROCESSES FOR VISCOUS OIL RECOVERY IN CARBONATE RESERVOIRS

SAUDI ARABIAN OIL COMPANY...

1. A composition for use in a polymer flooding operation in a viscous oil containing carbonate reservoir formation with in situ rock, the composition comprising:a polymer, the polymer operable to increase the viscosity of the composition; and
a smart water, the smart water operable to alter a wettability of the in situ rock,
wherein the smart water has a total dissolved solids of between 5,000 ppm and 7,000 ppm,
wherein the total dissolved solids comprises a salt, where the salts comprise a combination of sulfate, calcium, and magnesium ions, wherein the smart water comprises 300 ppm or less of divalent cations, wherein the smart water comprises 400 ppm or greater sulfates,
wherein the composition has a viscosity between 4 cP and 100 cP, wherein the composition is in the absence of a surfactant, wherein the polymer is selected from the group consisting of a copolymer of acrylamide and acrylate and a copolymer of acrylamide and acrylamide tertiary butyl sulfonate (ATBS).

US Pat. No. 10,988,671

CORROSION INHIBITION METHOD FOR DOWNHOLE TOOLS

KING FAHD UNIVERSITY OF P...

1. A method of downhole corrosion inhibition of a metal downhole tool during acid stimulation of an oil and gas well, the method comprising:injecting an acidic treatment fluid comprising 10 to 28 wt. % of an acid, based on a total weight of the acidic treatment fluid into a wellbore located in a geologic formation, and then
injecting 0.01 to 5% of a pyrazine corrosion inhibitor by weight per total volume of the acidic treatment fluid into the wellbore, and
allowing the pyrazine corrosion inhibitor to contact a surface of the metal downhole tool in the wellbore,
wherein the pyrazine corrosion inhibitor inhibits corrosion of the metal downhole tool, and
wherein the pyrazine corrosion inhibitor is at least one selected from the group consisting of 2,3-pyrazine dicarboxylic acid, and 2-methoxy-3-(1-methylpropyl) pyrazine,
wherein the acidic treatment fluid further comprises 0.01 to 0.5% of an intensifier by weight per total volume of the acidic treatment fluid, and wherein the intensifier is at least one selected from the group consisting of CuI, KI, and NaI, and
wherein the acidic treatment fluid further comprises 0.001 to 0.5% of a sulfur-containing compound by weight per total volume of the acidic treatment fluid, wherein the sulfur-containing compound is at least one selected from the group consisting of a mercapto heteroarene, a thioglycol compound, and a thiourea compound.

US Pat. No. 10,988,670

CORROSION INHIBITION METHOD FOR DOWNHOLE METAL TUBING

KING FAHD UNIVERSITY OF P...

1. A method of inhibiting corrosion of a metal tubing during acid stimulation of an oil and gas well, the method comprising:concurrently injecting an emulsion of an aqueous acidic treatment fluid and an oil comprising 10 to 28 wt. % of an acid, based on a total weight of the aqueous acidic treatment fluid, and 0.01 to 5% of a pyrazine corrosion inhibitor by weight per total volume of the acidic treatment fluid into the oil and gas well, and
allowing the pyrazine corrosion inhibitor to contact a surface of the metal tubing in the oil and gas well,
wherein the pyrazine corrosion inhibitor inhibits corrosion of the metal tubing, and
wherein the pyrazine corrosion inhibitor is at least one selected from the group consisting of 2,3-pyrazine dicarboxylic acid, and 2-methoxy-3-(1-methylpropyl) pyrazine,
wherein the aqueous acidic treatment fluid further comprises 0.01 to 0.5% of an intensifier by weight per total volume of the aqueous acidic treatment fluid, and wherein the intensifier is at least one selected from the group consisting of CuI, KI, and NaI and
wherein the aqueous acidic treatment fluid further comprises 0.001 to 0.5% of a sulfur-containing compound by weight per total volume of the aqueous acidic treatment fluid, wherein the sulfur-containing compound is at least one selected from the group consisting of a mercapto heteroarene, a thioglycol compound, and a thiourea compound.

US Pat. No. 10,988,669

USE OF BERBERINE AS CORROSION INHIBITOR IN WELL OPERATIONS

Halliburton Energy Servic...

1. A method of inhibiting corrosion of a metal surface in a wellbore, comprising:providing a treatment fluid comprising a corrosion inhibitor and an aqueous component, wherein the corrosion inhibitor comprises a deoiled mustard cake as a source of berberine, wherein the aqueous component comprises saltwater; and
introducing the treatment fluid into a wellbore.

US Pat. No. 10,988,668

TREATMENT FLUIDS FOR REDUCING SUBTERRANEAN FORMATION DAMAGE

Halliburton Energy Servic...

1. A composition comprising:a base fluid;
an inclusion complex comprising a cyclodextrin compound and an acid precursor ester; and
a filter cake comprising a bridging agent;
wherein the inclusion complex is formed by combining the acid precursor ester and the cyclodextrin compound as a solution with stirring for at least two hours, wherein the inclusion complex delays hydrolysis of the acid precursor ester; and wherein molar ratio of the acid precursor ester to the cyclodextrin compound in the inclusion complex is a ratio of about 1:1 to about 20:1.

US Pat. No. 10,988,662

COMPOSITION OF ENCAPSULATED CHEMICAL ADDITIVES AND METHODS FOR PREPARATION OF THE SAME

SAUDI ARABIAN OIL COMPANY...

1. A method of using an encapsulated additive in a cementing application, the method comprising the steps of:mixing the encapsulated additive with a cement slurry to produce an additive slurry, where the cement slurry comprises a cement and a mix water, where the encapsulated additive is formed by the steps of:
applying a base film-forming monomer to a solid cement additive;
forming a coating layer surrounding the solid cement additive, the coating layer comprising the base film-forming monomer;
applying an overlay film-forming monomer to the coating layer surrounding the solid cement additive; and
reacting the base film-forming monomer and the overlay film-forming monomer to produce a polymer shell,
where the polymer shell comprises a crosslinked polymer, the crosslinked polymer comprising aramides,
where the polymer shell surrounds the solid cement additive, and
where the polymer shell has a permeability to water allowing controlled release of the solid cement additive;
placing the additive slurry in a formation; and
releasing the solid cement additive from the surrounding polymer shell.

US Pat. No. 10,988,661

MITIGATION OF ANNULAR PRESSURE BUILD-UP USING TREATMENT FLUIDS COMPRISING CALCIUM ALUMINATE CEMENT

Halliburton Energy Servic...

1. A method of treating a well comprising:storing a treatment fluid comprising a calcium aluminate cement, a cement set retarder present in an amount of about 0.01% to about 10% by weight of the calcium aluminate cement, a dispersant, and water in a pumpable fluid state for at least about 1 day, wherein the calcium aluminate cement comprises calcium aluminates in an amount greater than 50% by weight of dry calcium aluminate cement;
introducing the treatment fluid into a wellbore without the calcium aluminate cement being activated, wherein the calcium aluminate cement is present in the treatment fluid in an amount of about 40% to about 70% by weight of the treatment fluid; and
removing a portion of the treatment fluid from the wellbore, wherein of the treatment fluid remaining in the wellbore remains static and in a pumpable fluid state for a period of about 1 day or longer,wherein the treatment fluid remaining static in the wellbore is activated by heat and remains fluid and pumpable up to 350° F., and wherein the treatment fluid remaining static in the wellbore and activated by heat sets into a hardened mass,wherein the portion of the treatment fluid removed from the wellbore is removed before the treatment fluid remaining static in the wellbore sets into a hardened mass.

US Pat. No. 10,988,655

COMPOSITION FOR THERMAL STORAGE AND HEAT TRANSFER APPLICATIONS

HINDUSTAN PETROLEUM CORPO...

1. A method for preparation of a composition, the method comprising:a) forming a solid mixture by contacting at least one nanoparticle with at least one alkali metal salt and a metal salt having water of crystallization, wherein the at least one nanoparticle is selected from the group consisting of molybdenum disulfide, activated carbon, activated carbon sphere, and combinations thereof, the at least one nanoparticle having a particle size that is greater than 30 nm and no more than 500 nm;
b) subjecting the solid mixture to a temperature in the range of 100 to 200° C. in a closed system to obtain dispersed nanoparticles in a mixture of salts;
c) reducing the pressure in the closed system to a reduced pressure; and
d) removing at least some water from the dispersed nanoparticles in the mixture of salts at the reduced pressure to obtain the composition.

US Pat. No. 10,988,654

THERMAL STORAGE WITH PHOSPHORUS COMPOUNDS

Kraftblock GmbH, Sulzbac...

1. A composition for thermal storage, comprising:a. solid core particles,
b. a shell surrounding each core particle, said shell comprising at least one shell phosphorous-containing oligomer, wherein the shell phosphorous-containing oligomer is bound to the core particles by chemisorption or physiosorption, and
c. a matrix comprising at least one matrix phosphorous-containing oligomer,
wherein the number of repeating units in the at least one shell phosphorous-containing oligomer is less than the number of repeating units in the matrix phosphorous-containing oligomer.

US Pat. No. 10,988,653

LUBRICATING OIL COMPOSITION FOR REFRIGERATORS

IDEMITSU KOSAN CO., LTD.,...

1. A composition comprising:(i) a refrigerant comprising at least one unsaturated fluorinated hydrocarbon represented by the following formula (A):
CpOqFrRs  (A),
wherein:
R represents H;
p represents an integer of 2 to 6;
q represents 0;
r represents an integer of 1 to 12;
s represents an integer of 0 to 11; and
the at least one unsaturated fluorinated hydrocarbon comprises at least one carbon-carbon unsaturated bond; and
(ii) a lubricating oil composition for a refrigerator comprising a base oil comprising, as a main component, a polyoxyalkylene glycol,
wherein the polyoxyalkylene glycol is at least one selected from the group consisting of a polyoxypropylene glycol dimethyl ether of the following formula (II):

wherein x represents a number from 6 to 80,
a polyoxyethylene polyoxypropylene glycol dimethyl ether of the following formula (III):

wherein a and b each is 1 or more, and a total of a and b is a number from 6 to 80, and
a polyoxypropylene glycol monobutyl ether of the following formula (IV):

wherein x represents a number from 6 to 80.

US Pat. No. 10,988,652

METHOD FOR USING A MIXTURE OF FLUORINATED HYDROCARBONS AS A REFRIGERANT, AND A REFRIGERATION UNIT USING THE MIXTURE AS A REFRIGERANT

DAIKIN INDUSTRIES, LTD., ...

23. A refrigeration unit using a mixture of fluorinated hydrocarbons as a refrigerant,(1) the mixture comprising difluoromethane (R32), pentafluoroethane (R125) and 1,1,1,2-tetrafluoroethane (R134a) in amounts such that the sum of the concentrations thereof is 99.5 wt % or more;
(2) the composition ratio of the fluorinated hydrocarbons contained in the mixture falling within a triangle having, as vertices, the following three points in a ternary composition diagram in which the sum of the concentrations of R32, R125, and R134a is 100 wt %,
point A?(R32/R125/R134a=35.6/16.4/48.0 wt %),
point F?(R32/R125/R134a=30.4/11.5/58.1 wt %), and
point G (R32/R125/R134a=29.4/14.1/56.5 wt %); and
(3) the refrigeration unit comprising a heat exchanger in which a flow of the refrigerant and a flow of an external heat medium are counter flows.

US Pat. No. 10,988,649

METHOD FOR IMPARTING WATER REPELLENCY TO SUBSTRATE, SURFACE TREATMENT AGENT, AND METHOD FOR SUPPRESSING COLLAPSE OF ORGANIC PATTERN OR INORGANIC PATTERN IN CLEANING SUBSTRATE SURFACE WITH CLEANING LIQUID

Tokyo Ohka Kogyo Co., Ltd...

1. A method for imparting water repellency to a substrate, the method comprising exposing a surface of a substrate to a surface treatment agent,wherein at least a part of the surface of the substrate, to which water repellency is to be imparted, is made of TiN, TaN, or W,
wherein the surface treatment agent comprises a water-repelling agent (A) and a nitrogen-containing heterocyclic compound (B), and
wherein the water-repelling agent (A) comprises an alkoxymonosilane compound having a hydrophobic group bonded to a silicon atom.

US Pat. No. 10,988,647

SEMICONDUCTOR SUBSTRATE MANUFACTURING METHOD, SEMICONDUCTOR DEVICE, AND METHOD FOR MANUFACTURING SAME

MITSUI CHEMICALS, INC., ...

1. A method for manufacturing a semiconductor substrate, comprising:forming a polyimide layer on a support material;
bonding the support material and a circuit-formed face of a semiconductor wafer with the polyimide layer being interposed therebetween;
grinding a non-circuit-formed face of the semiconductor wafer to which the support material is bonded;
releasing the support material from the polyimide layer; and
releasing the polyimide layer from the semiconductor wafer, wherein
a polyimide for use in the polyimide layer has a glass transition temperature of 210° C. or less and is dissolvable in a solvent; wherein
the polyimide comprises a polycondensation unit of a tetracarboxylic dianhydride (?) and a diamine (?);
the tetracarboxylic dianhydride (?) comprises an aromatic tetracarboxylic dianhydride (?1) having a benzophenone backbone, represented by the following formula (1), or the diamine (?) comprises an aromatic diamine (?1) having a benzophenone backbone, represented by the following formula (2),

a total amount of the aromatic tetracarboxylic dianhydride (?1) and the aromatic diamine (?1) is 5 to 49 mol % based on a total amount of the tetracarboxylic dianhydride (?) and the diamine (?);
the diamine (?) comprises an aliphatic diamine (?5) represented by the following formula (3) or (4),
wherein in formula (3), R1 is an aliphatic chain having a main chain containing any one or more atoms of C, N, and O, a total number of atoms constituting the main chain is 7 to 500, the aliphatic chain further has a side chain containing any one or more atoms of C, N, H, and O, and a total number of atoms constituting the side chain is 10 or less,H2N—R2—NH2  (4)wherein in formula (4), R2 is an aliphatic chain having a main chain containing any one or more atoms of C, N, and O, a total number of atoms constituting the main chain is 5 to 500, the aliphatic chain further has a side chain containing any one or more atoms of C, N, H, and O, and a total number of atoms constituting the side chain is 10 or less; andthe polyimide has an amine equivalent of 4,000 to 20,000.

US Pat. No. 10,988,646

ADHESIVE COMPOSITION, AND METHOD OF BONDING AN ADHEREND AND METHOD OF PRODUCING A STACK, EACH OF WHICH USES THE SAME

FURUKAWA ELECTRIC CO., LT...

1. An adhesive composition, comprising:a polyalkylene oxide-added polyfunctional epoxy compound (a) represented by formula (A);
a polyfunctional (meth)acrylate monomer (b); and
a photo-acid generator (c):

wherein R designates an alkylene group having 1 to 4 carbon atoms; X designates a divalent linking group having a ring structure and 6 to 20 carbon atoms, or an alkylene group having 1 to 4 carbon atoms; and m and n each are 0, or a positive number, independently, wherein at least one of m and n is a positive number; and
wherein a content of the polyfunctional (meth)acrylate monomer (b) in the adhesive composition is 20 mass % or less.

US Pat. No. 10,988,644

HYDROCARBON RESIN, METHOD FOR PREPARING HYDROCARBON RESIN, AND ADHESIVE COMPOSITION

KOLON INDUSTRIES, INC., ...

1. A method of preparing a hydrocarbon resin, comprising:(S1) preparing a polymer through thermal polymerization of a dicyclopentadiene and a C6-C20 olefin mixed together in a solvent; and
(S2) hydrogenating the polymer of S1 using a hydrogenation catalyst,
wherein an amount of the solvent is greater than an amount of dicyclopentadiene,
wherein the olefin in S1 is a linear alpha-olefin (LAO),
wherein the hydrocarbon resin comprises a repeating unit represented by Chemical Formula 1 and a repeating unit represented by Chemical Formula 2,
wherein Formula 1 is

wherein Formula 2 is

wherein R1 is hydrogen or a methyl group, R2 is a C4-C18 alkyl group when R1 is hydrogen, and R2 is a C3-C17 alkyl group when R1 is a methyl group, and m and n are each an integer of 0 to 10,
wherein the hydrocarbon resin includes 10 to 40 mol % of an olefin-derived component, and
wherein a ratio of a peak area of 5.9 ppm to 6.0 ppm to a peak area of 5.6 ppm to 5.9 ppm of the polymer in 1H-NMR spectrum is 0.14 to 0.27.

US Pat. No. 10,988,642

CURABLE AND OPTICALLY CLEAR PRESSURE SENSITIVE ADHESIVE AND USES THEREOF

1. A curable silicone pressure sensitive adhesive composition comprising a mixture of:(a) about 10-to about 98% of a reaction product consisting of (i), (ii), and (iii), wherein;
(i) a reactive polydimethylsiloxane polymer;
(ii) a reactive silicone resin; and
(iii) an acid or a base catalyst that has a pKa value equal to or less than ?6 or equal to or greater than 15;
(b) about 1 to about 45% of a terminal or pendant (meth)acrylate functionalized polydimethylsiloxane polymer or oligomer;
(c) about 1 to about 45% of a silicone resin or a polydimethylsiloxane polymer or oligomer; and
(d) about 0.001 to about 5% of a radical initiator; andwherein the cured adhesive has a transmittance, measured in accordance with ASTM E903 at 500 nm, of greater than 90%.

US Pat. No. 10,988,641

SURFACE REPAIR PATCH AND METHOD OF USING SAME

Surface Medical Inc., Al...

1. A repair device for repairing a damaged surface of a health care device, the repair device comprising a repair patch, a pre-mask layer, and a release liner;wherein the repair patch is smaller in area than the pre-mask layer and is interposed between the pre-mask layer and the release liner;
wherein the repair patch comprises a microbial growth rate of less than 10% based on test standard ASTM G21-96;
the repair device further comprising
a removable adhesive interposed between the pre-mask layer and the repair patch, wherein the removable adhesive is non-cytotoxic and hypoallergenic; and
a permanent adhesive interposed between the repair patch and the release liner, wherein the permanent adhesive is non-cytotoxic and hypoallergenic;wherein the pre-mask layer comprises a pair of non-adhesive portions extending along entireties of a pair of opposing ends of the pre-mask layer, each non-adhesive portion being located in an overhanging area of the pre-mask layer that is not in contact with the repair patch so as to allow a user to apply the repair patch without touching the removable adhesive,wherein the adhesion value between the removable adhesive and the repair patch is lower than the adhesion value between the permanent adhesive and the damaged surface of the health care device to which the repair patch can be applied, andwherein the adhesion value between the removable adhesive and the repair patch is between 28 g/cm and 200 g/cm per ASTM D3330 testing standards.

US Pat. No. 10,988,639

PHOTOCURABLE COMPOSITION FOR OPTICAL BONDING AGENT, IMAGE DISPLAY DEVICE APPLYING SAME, AND METHOD FOR MANUFACTURING IMAGE DISPLAY DEVICE

LG Chem, Ltd.

1. A photocurable composition for an optical bonding agent, comprising:an acrylic photocurable compound; and
a plasticizer,
wherein the acrylic photocurable compound comprises a monofunctional acrylic photocurable monomer and a (meth)acrylate-based photocurable polymer having a weight average molecular weight of 50,000 g/mol or less, and
the monofunctional acrylic photocurable monomer is comprised in an amount of 5 wt % to 15 wt %-in the photocurable composition for the optical bonding agent,
wherein the (meth)acrylate-based photocurable polymer is one selected from the group consisting of urethane (meth)acrylate, polyester (meth)acrylate, epoxy (meth)acrylate, polyether (meth)acrylate, polybutadiene (meth)acrylate, and a combination thereof, and
wherein the (meth)acrylate-based photocurable polymer comprises both a monofunctional (meth)acrylate-based photocurable polymer and a difunctional (meth)acrylate-based photocurable polymer,
wherein the monofunctional acrylic photocurable monomer is lauryl (meth)acrylate, and
wherein the curing shrinkage is less than or equal to 1.2%.

US Pat. No. 10,988,634

MIXED COMPOSITION

SUMITOMO CHEMICAL COMPANY...

1. A mixed composition comprising:an organosilicon compound (A) represented by the following formula (a1);
a solvent (C);
water (D); and
a carboxylic acid compound (E),
wherein the mixed composition has a mass ratio (D/A) of the water (D) to the organosilicon compound (A) of 30.0 or more

(wherein a plurality of Aa1 each independently represent a hydrolyzable group;
Za1 represents a hydrocarbon chain-containing group;
x is 0 or 1;
Ra10 represents an alkyl group having 6 to 20 carbon atoms, in which a part of methylene groups constituting the alkyl group may be replaced with an oxygen atom, and one or more hydrogen atoms may be replaced with a fluorine atom; and Za1 and Ra10 may be the same or different) and
wherein a metal compound (B) represented by the following formula (b1)
M(Rb10)r(Ab1)m-r  (b1)
wherein
M represents Al, Fe, In, Ge, Hf, Si, Ti, Sn, Zr, or Ta, Rb10 represents a hydrocarbon chain-containing group having 1 to 5 carbon atoms;
r is 0 or 1;
a plurality of Ab1 each independently represent a hydrolyzable group; and m denotes an integer of 3 to 5 depending on the metal atom M)
is mixed.

US Pat. No. 10,988,633

COMPOUND HAVING ISOCYANURIC SKELETON AND COMPOSITION IN WHICH SAID COMPOUND IS INCLUDED

DAIKIN INDUSTRIES, LTD., ...

1. A compound represented by the following formula (1):wherein R1 is a monovalent organic group containing a polyether chain other than those containing a urethane bond; X1 is a monovalent Si-containing crosslinkable group and X2 is a monovalent group; and the polyether chain is at least one chain selected from the group consisting of:a chain represented by the following formula:
—(OCF2CF2CX112)n11(OCF2CF(CF3))n12(OCF2CF2)n13(OCF2)n14(OC4F8)n15—wherein n11, n12, n13, n14, and n15 are each individually an integer of 0 or 1 or greater; X11s are each individually H, F, or Cl; and the repeating units are present in any order; anda chain represented by the following formula:
—(OC2F4—R11)f—wherein R11 is a group selected from OC2F4, OC3F6, and OC4F8; and f is an integer of 2 to 100.

US Pat. No. 10,988,628

INK SET AND RECORDING METHOD USING THE SAME

Seiko Epson Corporation

1. A recording method, comprising:providing an ink set including a reaction liquid containing coagulant, a first ink containing a first color material, and a second ink containing a second color material;
imparting the reaction liquid of the ink set to a non-absorptive recording medium or a low-absorptive recording medium;
imparting the first ink of the ink set to the area to which the reaction liquid is imparted; and
imparting the second ink of the ink set to the area to which the first ink is imparted,
wherein, before the imparting of the second ink, the reaction liquid and the first ink that are each imparted to the recording medium are heated,
a surface tension of the reaction liquid is less than or equal to 35 mN/m at a temperature of 25° C.,
a surface temperature of the recording medium is lower than or equal to 50° C. in the heating of the reaction liquid and the first ink that are each imparted to the recording medium before the imparting of the second ink, and
one of the first ink and the second ink is a white ink containing a white color material as the first color material or a metallic ink containing a metallic color material as the first color material, and the other of the first ink and the second ink is a yellow ink, a magenta ink, or a cyan ink containing the second color material or a black ink containing a black color material as the second color material.

US Pat. No. 10,988,626

CORROSION INHIBITING COMPOSITIONS AND METHODS OF MAKING AND USING

HONDA MOTOR CO., LTD., T...

1. A coating for inhibiting corrosion on a metal substrate, the coating comprising a corrosion inhibiting composition comprising:a) a base comprising a volatile organic solvent;
b) a first plurality of carriers dispersed in the base, each comprising a first carrier body encapsulating a first encapsulated active component, the first encapsulated active component comprising a first corrosion inhibitor, the first corrosion inhibitor comprising an organic phosphonate, wherein the first carrier body is formed of a first degradable material; and
c) a second plurality of carriers dispersed in the base, each comprising a second carrier body encapsulating a second encapsulated active component, the second encapsulated active component comprising a second corrosion inhibitor, the second corrosion inhibitor comprising an organic compound including a ring structure,
wherein the second carrier body is formed of a second degradable material,
wherein the first encapsulated active component is different from the second encapsulated active component,
wherein the second plurality of carriers are free of the first corrosion inhibitor,
wherein the coating, at a thickness of 25 microns, exhibits a creep value of about 0.6 mm or less according to a hot salt water test, and
wherein the hot salt water test comprises:
cutting an X-shaped cut into a test piece of a metal substrate comprising a base material using an SK2 cutting knife having a hardness of HV 820+/?30, wherein the X-shaped cut has a cross angle from 60° to 90° and reaches the base material of the metal substrate,
immersing the test piece in a 5 wt % NaCl solution at 55° C. in a container, sealing the container,
removing the test piece from the container after 240 hours and rinsing and wiping the test piece,
measuring a width of any rust and/or blister on the test piece in order to determine a blister width, and
attaching a 12 or 24 mm wide piece of cellophane adhesive tape to the rust and/or blister, holding the edge of the adhesive tape to form an angle of 45° between the adhesive tape and test piece, peeling off the adhesive tape, and
measuring a width of any resulting peeled portion in order to determine a peeling width,
wherein the creep value is the larger of the peeling width and the blister width.

US Pat. No. 10,988,621

PIGMENT FOR PAPER AND COATINGS

BASF CORPORATION, Florha...

1. A fully or partially calcined kaolin having a GE brightness of at least about 92 and a particle size distribution of:equal to or greater than 99% by weight of particles with an equivalent spherical diameter (e.s.d.) of less than 10 microns;
equal to or greater than 93% by weight of particles with an e.s.d. of less than 5 microns;
equal to or greater than 85% by weight of particles with an e.s.d. of less than 2 microns;
equal to or greater than 77% by weight of particles with an e.s.d. of less than 1 micron; and
equal to or greater than 25% by weight of particles with an e.s.d. of less than 0.5 micron, wherein the fully or partially calcined kaolin has a +325 mesh residue content of 300 ppm or less and an oil absorption of from 100 to 140 lbs oil/100 lbs fully or partially calcined kaolin.

US Pat. No. 10,988,620

COMPOSITE ELEMENT COMPRISING A BIPHASIC SILICA AND CARBON NANOTUBE-BASED MATERIAL

Luxembourg Institute of S...

1. A composite material comprising at least one polymer matrix, said polymer matrix comprising at least one inorganic load composed of a biphasic material, the biphasic material comprising at least one mesoporous substrate at least partially coated with carbon nanotubes wherein the at least one mesoporous substrate is a mesoporous substrate with non-organized porosity;wherein the mesoporous substrate with non-organized porosity comprises silica from diatoms,
wherein a composition of the mesoporous substrate with non-organized porosity in the composite material is comprised between 2% and 10%; and
wherein the polymer matrix is composed of polymethylmethacrylate and/or at least one elastomer.

US Pat. No. 10,988,618

SELF-ASSEMBLED NANO-STRUCTURED PARTICLE AND METHODS FOR PREPARING

1. A process for forming a nanoparticle, comprising:a. heating an acid medium with agitation;
b. adding a host vessel comprising a carbohydrate with agitation to the acid medium to form a gel, wherein the carbohydrate is a simple sugar, a disaccharide, a polysaccharide or cyclodextrin;
c. adding a solid guest particle with agitation to the gel to form a mixture;
d. stirring the mixture at an elevated temperature for a set time to allow particle size reduction and annealing to occur;
e. quenching the mixture with water or a dry basic compound;
f. dispersing the quenched mixture in water to form a colloidal dispersion of nanoparticles;
g filtering the colloidal dispersion; and
h. stabilizing the filtered colloidal dispersion of nanoparticles by (i) carboxymethylation of the nanoparticles using an acid, wherein the acid is chloroacetic acid or dichloroacetic acid or (ii) by reacting the dispersion with another reactive component that is a base comprising a sodium or other alkali metal hydroxide.

US Pat. No. 10,988,614

URETHANE COMPOSITION, POLYURETHANE ELASTOMER AND TRANSMISSION BELT

Bando Chemical Industries...

1. A transmission belt, wherein the belt is used in looping over a pulley and at least a surface thereof to be in contact with the pulley is formed of a polyurethane elastomer, wherein the polyurethane elastomer is formed of a urethane composition comprising a urethane prepolymer, which is a reaction product between a long chain polyol having a number average molecular weight of 300 or more and diphenylmethane diisocyanate, as a main component and further comprising a plasticizer and a polyol crosslinking agent, wherein the long chain polyol is a polyether polyol, wherein the polyol crosslinking agent comprises a long chain polyol having a number average molecular weight of 650 or more, wherein a mass proportion of an isocyanate group occupied in a total mass of the polyether polyol, the long chain polyol having a number average molecular weight of 300 or more that can be included in the polyol crosslinking agent, and the diphenylmethane diisocyanate is 8.5 mass % or more and 10 mass % or less.

US Pat. No. 10,988,613

RESIN COMPOSITION, PRODUCTION PROCESS THEREOF AND OPTICAL INSTRUMENT

CANON KABUSHIKI KAISHA, ...

1. A resin composition comprising:a resin;
a carbon fiber; and
an ionically conductive liquid,
wherein the ionically conductive liquid coats a surface of the carbon fiber, and
wherein the ionically conductive liquid is a mixture of a salt having ionic conductivity when ionically dissociated and a solvent, which dissolves the salt,
wherein the ionically conductive liquid contains a sulfur element (S), and
wherein a concentration of the sulfur (S) element contained in the ionically conductive liquid as measured by SEM-EDS on the surface of the carbon fiber is 1.3 times or more as much as a concentration of the sulfur (S) element contained in the resin.

US Pat. No. 10,988,610

ELECTROCHEMICAL SENSOR SYSTEM

Ascensia Diabetes Care Ho...

1. A method of determining an analyte concentration, the method comprising the acts of:placing a hydrogel composition on skin, the hydrogel composition comprising a first monomer, a second monomer, a cross-linking agent, and a solvent, the first monomer being selected from Formula I
wherein the combination of R and R1 is selected from 1 carbon to 5 carbon atoms such that a 3-7 member heterocyclic moiety is formed;the second monomer being selected from Formula II, wherein Formula II is
wherein R3 and R4 are independently selected from H, CH3, (C3-C18)alkyl, wherein the alkyl is optionally substituted with one or more substituents selected from halos, haloalkyls, cycloalkyls, nitros, cyanos, 4-8 member heterocyclic moieties, wherein the heterocyclic moieties are optionally substituted with one or more alkyls, halos, haloalkyls, cycloalkyls, nitros, and cyanos;(C3-C7)cycloalkyl, wherein the cycloalkyl is optionally substituted with one or more substituents selected from alkyls, halos, haloalkyls, cycloalkyls, nitros, and cyanos; and
aromatic moieties, wherein the aromatic moieties are optionally substituted with one or more substituents selected from alkyls, halos, haloalkyls, cycloalkyls, nitros, and cyanos,
with the proviso that when R3 is H or CH3, then R4 is (C3-C18)alkyl, (C3-C7)cycloalkyl or an aromatic moiety, wherein the alkyl, cycloalkyl or aromatic moiety is optionally substituted with one or more substituents,
with the proviso that when R4 is H or CH3, then R3 is (C3-C18)alkyl, (C3-C7)cycloalkyl or an aromatic moiety, wherein the alkyl, cycloalkyl or aromatic moiety is optionally substituted with one or more substituents;
wherein the ratio of the first monomer to the second monomer is from about 20:80 to about 80:20;
providing a sensor, the hydrogel composition located generally between and coupling the skin and the sensor; and
sampling of the interstitial fluid to determine the analyte concentration using the sensor.

US Pat. No. 10,988,608

RESIN COMPOSITION, RESIN FILM, METHOD OF MANUFACTURING RESIN FILM, OPTICAL FILTER, SOLID-STATE IMAGING ELEMENT, IMAGE DISPLAY DEVICE, AND INFRARED SENSOR

FUJIFILM Corporation, To...

1. A resin composition comprising:an organic pigment;
a resin; and
a solvent,
wherein the organic pigment includes a near infrared absorbing organic pigment having a maximum absorption wavelength in a wavelength range of 700 to 1000 nm, and the near infrared absorbing organic pigment includes at least one compound selected from the group consisting of a compound represented by Formula (PP), a compound represented by Formula (SQ), and a compound represented by Formula (C), and
wherein a content of a Na atom is 0.01 to 50 mass ppm with respect to a total solid content of the resin composition,

in Formula (PP), R21 and R22 each independently represent an alkyl group, an aryl group or a heteroaryl group,
R23, R24, R25, R26 each independently represent a cyano group, an acyl group, an alkoxycarbonyl group, an alkyl sulfinyl group, an arylsulfinyl group or a heteroaryl group,
R27 and R28 each independently represent a hydrogen atom, an alkyl group, an aryl group, a heteroaryl group, —BR29R30, or a metal atom,
R27 optionally forms a covalent bond or a coordinate bond with R21, R23, or R25,
R28 optionally forms a covalent bond or a coordinate bond with R22, R24, or R26, and
R29 and R30 each independently represent a hydrogen atom, a halogen atom, an alkyl group, an aryl group, a heteroaryl group, an alkoxy group, an aryloxy group, or a heteroaryloxy group, and R29 and R30 are optionally bonded to each other to form a ring,

in Formula (SQ), A1 and A2 each independently represent an aryl group, a heteroaryl group, or a group represented by Formula (A-1); and

in Formula (A-1), Z1 represents a nonmetallic atomic group forming a nitrogen-containing heterocyclic ring, R2 represents an alkyl group, an alkenyl group, or an aralkyl group, d represents 0 or 1, and a wavy line represents a linking hand, and
Formula (C)

in Formula (C), Z1 and Z2 are each independently a nonmetallic atomic group forming a 5-membered or 6-membered nitrogen-containing heterocyclic ring that is optionally fused,
R101 and R102 each independently represent an alkyl group, an alkenyl group, an alkynyl group, an aralkyl group, or an aryl group,
L1 represents a methine chain having an odd number of methine groups,
a and b are each independently 0 or 1,
in a case where a is 0, a carbon atom and a nitrogen atom are bonded to each other by a double bond, and in a case where b is 0, a carbon atom and a nitrogen atom are bonded to each other by a single bond, and
in a case where a moiety represented by Cy in the formula is a cation moiety, X1 represents an anion, and c represents the number necessary for balancing the charge, in a case where the moiety represented by Cy in the formula is an anion moiety, X1 represents a cation, c represents a number necessary for balancing the charge, and in a case where the moiety represented by Cy in the formula is neutralized in the molecule, c is 0.

US Pat. No. 10,988,602

METHOD FOR TESTING THE IN SITU SILANIZATION OF BRIGHT FILLERS

LANXESS Deutschland GmbH,...

1. A method of in-situ testing of the silanization of light-colored fillers in rubbers, the method comprising:extruding a mixture comprising at least one silanized light-colored filler and at least one rubber to form an extrudate,
subjecting the extrudate to ultrasound waves within a frequency range from 4 to 10 MHz, and
measuring the signal intensity of the ultrasound waves after transmission of the ultrasound waves through the extrudate, wherein the measured intensity relates directly to an amount of silanization.

US Pat. No. 10,988,597

OXYGEN SCAVENGERS, COMPOSITIONS COMPRISING THE SCAVENGERS, AND ARTICLES MADE FROM THE COMPOSITIONS

Plastipak Packaging, Inc....

1. A compound having a structure represented by a formula:
wherein R27 represents six groups, each group independently selected from hydrogen,

provided that no more than four groups are hydrogen; and
wherein each occurrence of Q is independently N or P;
wherein R23, represents three groups, each group independently selected from hydrogen, halogen, C1-C4 alkyl, and an electron withdrawing group;
wherein R24, represents three groups, each group independently selected from hydrogen, halogen, C1-C4 alkyl, and an electron withdrawing group;
wherein R25, represents four groups, each group independently selected from hydrogen, halogen, C1-C4 alkyl, and an electron withdrawing group;
wherein each of Z10 and Z11, is independently hydrogen, halogen, C1-C4 alkyl, an electronic withdrawing group, or an electronic donating group; and
wherein each of Z12 and Z13, is independently hydrogen, halogen, C1-C4 alkyl, an electronic withdrawing group, or an electronic donating group.

US Pat. No. 10,988,594

POLYCARBONATE-BASED RESIN FOAM PARTICLE AND FOAM MOLDED BODY

SEKISUI PLASTICS CO., LTD...

1. Expanded particles of a polycarbonate-based resin comprising, as a base resin, a polycarbonate-based resin containing a component derived from bisphenol A,the expanded particles satisfying any one of the following conditions (a) to (c) in a GC/MS chart with a retention time as an abscissa obtained through measurement by a reactive pyrolysis GC/MS method utilizing reaction of methyl etherifying an ester bond contained in the polycarbonate-based resin through hydrolysis with tetramethylammonium hydroxide as a reaction reagent under condition of helium used as a carrier gas with a carrier gas flow rate of 34 mL/min:
(a) a peak derived from a molecular weight of from 145 to 230 and a peak derived from a molecular weight of from 320 to 350 are shown,
the peak derived from a molecular weight of from 145 to 230 is observed at a retention time in a range of ?15 minutes or less based on a retention time of a maximum peak showing the component derived from bisphenol A, and
the peak derived from a molecular weight of from 320 to 350 is observed at a retention time in a range of +10 minutes or less based on a retention time of a maximum peak showing the component derived from bisphenol A;
(b) a peak derived from a molecular weight of from 210 to 230 is shown, and
the peak derived from a molecular weight of from 210 to 230 is observed at a retention time in a range of 5 minutes or less based on a retention time of a maximum peak showing the component derived from bisphenol A; and
(c) a peak derived from a molecular weight of from 290 to 320 is shown, and
the peak derived from a molecular weight of from 290 to 320 is observed at a retention time in a range of 5 minutes or less based on a retention time of a maximum peak showing the component derived from bisphenol A.

US Pat. No. 10,988,592

FOAM MOLDING RESIN AND METHOD FOR MANUFACTURING FOAM MOLDED ARTICLE

KYORAKU CO., LTD., Kyoto...

1. A method of manufacturing a foam molded article, comprising the steps of:forming a foam parison by extruding, from a foam extruder, a melt-kneaded resin obtained by melt-kneading a foam molding resin and a foaming agent in the foam extruder, the foam molding resin having a melt tension of 192.5 mN and a shear viscosity of 368 Pa s, the shear viscosity being measured at a test temperature of 190 degrees Celsius at an apparent shear rate of 600/second according to JIS K 7199;
blow or vacuum molding the foam parison to obtain the foam molded article using split molds, wherein
the foam molding resin contains low-density polyethylene and high-density polyethylene in a mass ratio of 7:3; and
the foam extruder comprises a cylinder, a resin inlet, a foaming agent inlet, and a resin extrusion port,
the foam molding resin is injected into the cylinder via the resin inlet,
the foaming agent is injected into the cylinder via the foaming agent inlet,
the melt-kneaded resin is extruded from the resin extrusion port, and
a position of the foaming agent inlet is 0.3 L to 0.7 L where positions of ends of the cylinder on a side of the resin inlet and on a side of the resin extrusion port are defined to be 0 and L.

US Pat. No. 10,988,591

VINYL-LACTAM-BASED HYDROGEL COATINGS

Universidad Complutense D...

1. A product comprising:a) a polymeric substrate and
b) a hydrogel based on vinyl-lactam type monomers, without methacrylates or with ionic methacrylates, and at least two crosslinkers,
wherein there is an interface between the substrate and the hydrogel, the interface formed by a gradient of both the substrate and the hydrogel network, forming a semi-interpenetrated network structure.

US Pat. No. 10,988,585

RESIN SHEET AND CURED PRODUCT OF RESIN SHEET

Showa Denko Materials Co....

1. A resin sheet comprising:an epoxy resin comprising an epoxy resin oligomer and an epoxy resin monomer, wherein the epoxy resin oligomer has a number average molecular weight of from 600 to 2,300;
a curing agent; and
an inorganic filler,
wherein a content of the inorganic filler is more than 30% by volume but less than 80% by volume.

US Pat. No. 10,988,583

METHODS OF FORMING IONICALLY CROSS-LINKED GELS

Nordovo Biosciences AS, ...

1. A method of forming a cross-linked polymer gel comprising mixing a first solution and a second solution, wherein the first solution comprises a crosslinking agent and a first chelating agent; the second solution comprises a displacing agent; wherein at least one of the first or second solutions contains an ionotropic polymer; and wherein:(a) the ionotropic polymer has a lower affinity for the crosslinking agent than the first chelating agent,
(b) the first chelating agent has a higher affinity for the displacing agent than the crosslinking agent, and
(c) the crosslinking agent and the displacing agent are different multivalent metal ions.

US Pat. No. 10,988,578

COMPOSITIONS INCLUDING A SILSESQUIOXANE POLYMER AND A FREE SILOXANE, AND ARTICLES

3M Innovative Properties ...

1. A composition comprising:Component (A) comprising a silsesquioxane polymer comprising a three-dimensional network of Formula (I):

wherein:
each R1 and R2 is independently a (C1-C4)alkyl;
each L1 and L2 is independently a single bond, an alkylene, or an alkylene bonded to a group selected from oxy, thio, carbonyl, —NH—, and combinations thereof;
each R3 is independently a linear (C14-C100)alkyl;
each R5 is independently a (C1-C30)alkyl, a (C1-C30)fluorinated alkyl, or a (C2-C30)heteroalkyl having at least one oxygen, sulfur, or —NH— linkage;
with the proviso that L1, L2, and R5 are selected such that each Si atom is directly bonded to an alkylene or an alkyl;
m is an integer of at least 2;
n is an integer of 0 or above;
m+n is an integer of at least 10;
each oxygen atom at an asterisk (*) is bonded to another Si atom within the three-dimensional network; and
the silsesquioxane polymer is a solid at 25° C.; and
Component (B) comprising a free siloxane.

US Pat. No. 10,988,577

COPOLYMER OF DIALLYLAMINES AND SULFUR DIOXIDE, AND METHOD FOR PRODUCING SAME

NITTO BOSEKI CO., LTD., ...

1. A production method of a copolymer, comprising the step of copolymerizing a sulfonic acid salt or alkylsulfate salt of a diallylamine represented by Structural Formula 1, wherein R1 and R2 are each independently a hydrogen atom or a hydrocarbon group having 1 to 3 carbon atoms and X— is a sulfonic acid ion having 1 to 3 carbon atoms or an alkylsulfate ion having 1 to 3 carbon atoms, and sulfur dioxide represented by Structural Formula 2 in ethylene glycol or propylene glycol monomethyl ether, wherein the sulfonic acid salt or alkylsulfate salt of a diallylamine and the sulfur dioxide are present at a concentration of 1 to 70% by mass in the ethylene glycol or the propylene glycol monomethyl ether

US Pat. No. 10,988,576

COMPOUND

LG CHEM, LTD., Seoul (KR...

1. A phthalonitrile resin comprising a polymerized unit derived from a compound represented by an average composition of Formula 1 below and having at least one or more substituents of Formula 3 below:[R1R22SiO1/2]a[R1R2SiO2/2]b[R22SiO2/2]c[R1SiO3/2]d[R2SiO3/2]e[SiO4/2]f  [Formula 1]
wherein, R1 is a substituent of Formula 2 below, R2 is a hydrogen atom, an alkyl group, an alkenyl group or an alkoxy group, a, b and c are each a positive number, d, e and f are each 0 or a positive number, (b+d)/(b+c+d+e) is 0.05 to 0.35, b/(b+c) is 0.05 to 0.35, (b+c)/(a+b+c+d+e+f) is 0.5 to less than 1, and a+b+c+d+e+f is 1:

wherein, X is a single bond, an oxygen atom, a sulfur atom, —S(?O)2—, a carbonyl group, an alkylene group, an alkenylene group, an alkynylene group, —C(?O)—X1— or —X1—C(?O)—, where X1 is an oxygen atom, a sulfur atom, —S(?O)2—, an alkylene group, an alkenylene group or an alkynylene group, and R1 to R5 are each independently hydrogen, an alkyl group, an alkoxy group, a hydroxy group or a substituent of Formula 3 below

wherein, Y is a single bond, an oxygen atom, a sulfur atom, —S(?O)2—, a carbonyl group, an alkylene group, an alkenylene group, an alkynylene group, —C(?O)—X2— or —X2—C(?O)—, where X2 is an oxygen atom, a sulfur atom, —S(?O)2—, an alkylene group, an alkenylene group or an alkynylene group, and R6 to R10 are each independently hydrogen, an alkyl group, an alkoxy group or a cyano group, provided that at least two of R6 to R10 are each a cyano group;
and a polymerized unit of an aromatic amine compound.

US Pat. No. 10,988,574

METHOD OF PRODUCING OLIGOMER OR POLYMER WITH CARBONATE SEGMENT CHEMICAL STRUCTURE

1. A method of producing an oligomer or polymer with carbonate segment chemical structure, the method comprising the steps of:(1) introducing into a reactor high-molecular-weight polyester and reactive oligomer,
wherein the high-molecular-weight polyester is expressed by formula (A),

R? is branched or linear C1-6 alkylidene,
wherein the reactive oligomer is one selected from the group consisting of poly(polyol) and poly(polyamine);
(2) introducing into the reactor a carbonate compound and a catalyst such that the poly(polyol) reacts with the carbonate monomers by one-pot in situ to produce oligomer polycarbonate diol compound (HO—R?—O C(O)—O—R?—OH), wherein R? is a functional group derived from polyol, polyester polyol or polyether polyol, partially substitute for the chemical structure (—O—R?—O—) in the high-molecular-weight polyester, remove, by vacuum distillation-based regulation, alcohol (HO—R?—OH) produced as a result of ester exchange reaction and substitution, so as to produce a crude product, wherein R? is a functional group derived from polyol, polyester polyol or polyether polyol, partially substitute for chemical structure (—O—R?—O—) in the high-molecular-weight polyester, remove, by vacuum distillation-based regulation, alcohol (HO—R?—OH) produced as a result of ester exchange reaction and substitution, so as to produce the crude product; and
(3) introducing the crude product into water to obtain an oligomer or polymer with carbonate segment chemical structure.

US Pat. No. 10,988,573

POLYMERIC POLYOXAZOLINES

PPG Industries Ohio, Inc....

1. A coating composition comprising:(a) a polymer comprising acidic functionality, and
(b) a polymeric polyoxazoline crosslinking agent having the following structure:
where X is the residue of a polymeric polyol after reaction with a dicarboxylic acid/anhydride;where R5 is an organic moiety; where Y is an organic moiety containing one or more oxazoline groups; and wherein each R10 is independently hydrogen or an organic moiety.

US Pat. No. 10,988,572

POLYMERS AND METHODS OF MAKING THE SAME

Alliance for Sustainable ...

1. A composition comprising:wherein:R2 comprises a hydrocarbon,
R3 comprises an unsaturated straight-chained hydrocarbon having between 2 and 4 carbon atoms, inclusively, and at least one double bond,
A comprises a benzene ring or a saturated straight-chained hydrocarbon having 3 or 4 carbon atoms,
1?x?1000, and
1?y?1000.

US Pat. No. 10,988,571

QUORUM SENSING BASED POLYMER FOR STIMULATION OF BIOFILMS AND RELATED PHENOTYPES, AND SYNTHESIS PROCESS THEREOF

FIB-SOL Life Technologies...

1. A polymer comprising a polymerization product of:one or more monomers having a structure of formula I or formula Ia, and
optionally, one or more comonomers having a structure selected from the group consisting of formulas II, III, IV, V and VI;
wherein formula I has a structure:

wherein R1 of formula I is hydrogen or a hydroxyl group, and wherein R2 of formula I is a C1-15 alkyl group or C1-15 alkenyl group;
wherein formula Ia has a structure:

wherein R2 of formula Ia is a C1-15 alkyl group or C1-15 alkenyl group;
wherein formula II has a structure:

wherein R1 to R4 of formula II are independently selected from the group consisting of hydrogen, halogen, alkyl, alkoxy, and an aromatic group, and wherein “n” of formula II is 1, 2, 3 or 4;
wherein formula Ill has a structure:

wherein R1 to R4 of formula Ill are independently selected from the group consisting of hydrogen, halogen, alkyl, alkoxy, and an aromatic group;
wherein formula IV has a structure:

wherein R1 to R4 of formula IV are independently selected from the group consisting of hydrogen, halogen, alkyl, alkoxy, and an aromatic group, and wherein “n” of formula IV is 1, 2 or 3;
wherein formula V has a structure:

wherein R1 to R6 of formula V are independently selected from the group consisting of hydrogen, halogen, alkyl, alkoxy, and an aromatic group, and wherein “n” of formula V is 0, 1, 2, 3, 4, or 5; and
wherein formula VI has a structure:

wherein R1 to R4 of formula VI are independently selected from the group consisting of hydrogen, halogen, alkyl, alkoxy, and an aromatic group;
and wherein the polymer is a homopolymer, copolymer or heteropolymer.

US Pat. No. 10,988,570

MOLECULES AND OLIGOMERS FOR ENDOTHERMIC SINGLET FISSION

Alliance for Sustainable ...

1. A composition comprising:a repeat unit defined by
wherein:R1 and R2 each comprise a hydrocarbon chain having between 1 and 10 carbon atoms, and
n is between 1 and 10, inclusively.

US Pat. No. 10,988,569

CURABLE COMPOSITION AND CURED PRODUCT FROM SAME

DAICEL CORPORATION, Osak...

1. A curable composition for production of an optical component by molding using silicone molds, the curable composition comprising:curable compounds; and
a cationic initiator,
the curable compounds comprising:
(A) a cycloaliphatic epoxy compound;
(B) an oxetane compound, and
(C) a glycidyl ether epoxy compound,
the oxetane compound (B) being present in a content of 10 to 45 weight percent of the totality of all the curable compounds contained in the curable composition,
90 weight percent or more of the totality of all the curable compounds contained in the curable composition being a compound or compounds having a solubility parameter of 9.0 (cal/cm3)½ or more as determined at 25° C. by Fedors' method,
wherein the cycloaliphatic epoxy compound (A) is a compound represented by Formula (a):

wherein R1 to R18 are each, identically or differently, selected from hydrogen, halogen, a hydrocarbon group optionally containing oxygen or halogen, and optionally substituted alkoxy; and X is selected from a single bond and a linkage group,
wherein the linkage group is selected from divalent hydrocarbon groups, alkenylenes with part or all of carbon-carbon double bond(s) being epoxidized, carbonyl, ether bond, ester bond, amido, and groups each including two or more of these groups linked to each other,
wherein the glycidyl ether epoxy compound (C) comprises an aromatic glycidyl ether epoxy compound and an alicyclic glycidyl ether epoxy compound, and
wherein the cycloaliphatic epoxy compound (A), the oxetane compound (B), and the glycidyl ether epoxy compound (C) are present in a total content of 90 weight percent or more of the totality of all the curable compounds contained in the curable composition.

US Pat. No. 10,988,568

CURABLE COMPOSITION AND CURED PRODUCT FROM SAME

DAICEL CORPORATION, Osak...

1. A curable composition for production of an optical component by molding using silicone molds, the curable composition comprising:curable compounds; and
a cationic initiator,
the curable compounds comprising
(A) a cycloaliphatic epoxy compound;
(B) an oxetane compound; and
(C) a glycidyl ether epoxy compound,
the cycloaliphatic epoxy compound (A) being a compound represented by Formula (a):

wherein R1 to R18 are each, identically or differently, selected from, hydrogen, halogen, a hydrocarbon group optionally containing oxygen or halogen, and optionally substituted alkoxy; and X is selected from a single bond and a linkage group,
wherein the linkage group is selected from divalent hydrocarbon groups, alkenylenes with part or all of carbon-carbon double bond(s) being epoxidized, carbonyl, ether bond, ester bond, amido, and groups each including two or more of these groups linked to each other,
wherein the cycloaliphatic epoxy compound (A) is present in a content of 10 weight percent or more of the totality of all the curable compounds contained in the curable composition,
wherein the glycidyl ether epoxy compound (C) comprises an aromatic glycidyl ether epoxy compound, and an alicyclic glycidyl ether epoxy compound,
wherein the cycloaliphatic epoxy compound (A), the oxetane compound (B), and the glycidyl ether epoxy compound (C) are present in combination in a total content of 90 weight percent or more of the totality of all the curable compounds contained in the curable composition, and
wherein of the totality of all the curable compounds contained in the curable composition, 10 to 50 weight percent are a curable compound or compounds having a molecular weight of 400 or more.

US Pat. No. 10,988,564

PROCESS FOR PRODUCING DIMETHOXYMETHANE OLIGOMERS

Lyondell Chemical Technol...

1. A method of producing dimethoxymethane oligomers (DMMn), the method comprising:reacting a formaldehyde source and dimethoxymethane monomer (DMM1) in the presence of an acidic zeolite catalyst to produce a reaction effluent comprising DMMn and unreacted DMM1; and
separating, from the reaction effluent, DMM1-2 including unreacted DMM1 and DMMn having a chain length n equal to 2 (DMM2), dimethoxymethane oligomers having a chain length n in the range of from 2-5 (DMM2-5), dimethoxymethane oligomers having a chain length n of ?5 (DMM5+), or a combination thereof,
wherein the separating comprises distillation in the presence of at least one alcohol, a distillate fuel, or both, wherein the separating comprises subjecting at least a portion of the reaction effluent comprising DMMn to a first distillation to separate a first distillation overhead comprising DMM1-2 and a first distillation bottoms comprising DMMn wherein n is greater than or equal to 2 (DMM2+); wherein the method further comprising subjecting the first distillation bottoms comprising DMMn to a second distillation to produce a second distillation overhead comprising DMM2-5 and a second distillation bottoms comprising DMM5+; wherein the reaction effluent comprises:
greater than 0 to less than 1,0 volume percent of DMM2;
greater than 0 to less than 25 volume percent of DMM3;
greater than 0 to less than 25 volume percent of DMM4; and
greater than 0 to less than 2,0 volume percent of DMM5.

US Pat. No. 10,988,561

METHOD FOR INDUSTRIAL PRODUCTION OF TRANS-BUTADIENE-ISOPRENE COPOLYMER RUBBER AND APPARATUS THEREFOR

QINGDAO UNIVERSITY OF SCI...

1. A method for industrial production of a bulk-polymerized butadiene-isoprene copolymer rubber having a trans-1,4-structure, the method comprising:vacuuming a polymerization apparatus and replacing water and oxygen within the polymerization apparatus fully with nitrogen,
subsequent to the vacuuming and replacing, sending refined isoprene monomer, butadiene monomer, cocatalyst, electron donor, primary catalyst and hydrogen to the polymerization apparatus for bulk polymerization of the butadiene and isoprene according to a respective predetermined dosage through a batching device, wherein a mole ratio of titanium and/or vanadium element within the primary catalyst to monomer is (0.01-100)×10?5:1, a mole ratio of Al element in the cocatalyst to the titanium and/or vanadium element within the primary catalyst is 1-200:1, a mole ratio of hydrogen to the titanium and/or vanadium element within the primary catalyst is 1-2000:1, a copolymerization temperature is 20-100° C., a feed mole ratio of butadiene to isoprene is 0.01-50:100, a mole ratio of the electron donor to the titanium and/or vanadium element within the primary catalyst is 0.1-10:1, and a duration of constant temperature polymerization is 2-48 hours,
wherein the polymerization of the butadiene and isoprene occurs in the absence of a solvent;
after the polymerization reaches a predetermined time, transferring a produced polymer system to a termination device through a polymerization device pipeline, wherein a termination agent is added to the termination device to cause termination of the polymerization;
subsequently transferring the polymer system from the termination device to an extrusion and devolatilization device, wherein an antioxidant and a rubber auxiliary agent of a predetermined dose is added to the extrusion and devolatilization device; removing unreacted butadiene and isoprene monomers by the extrusion and devolatilization device under reduced pressure, then separating and refining the butadiene and isoprene monomers with a separation device and a refining device, and transferring the separated and refined butadiene and isoprene monomers to the polymerization apparatus or to a storage tank;
granulating the polymers by the extrusion and devolatilization device to produce granular butadiene-isoprene copolymer rubber having a trans-1,4-structure (TBIR), drying the granular butadiene-isoprene copolymer rubber to dried polymer granules, and then metering and packaging dried the polymer granules,
wherein the primary catalyst is a titanium and/or vanadium catalyst supported on a carrier, among which the titanium and/or vanadium element occupies 1%-5% of the primary catalyst's total mass, and an internal electron donor occupies 0.1%-20% of the primary catalyst's total mass; and the carrier of the primary catalyst is selected from MgCl2, MgBr2, MgI2, and SiO2;
the titanium catalyst is a compound selected from TiCl4, TiBr4 and TiI4;
the vanadium catalyst is a compound selected from VCl3, VBr3, VOCl3, VOBr3, VCl4, VBr4, V2O5, and mixtures thereof;
the internal electron donor is a compound selected from ester, ether, ketone, anhydride compounds, and mixtures thereof;
the cocatalyst is a compound selected from triethyl aluminum, tri-isobutyl aluminum, dimethylaluminium chloride, methylaluminum dichloride, diethyl aluminium chloride, ethylaluminum dichloride, diisobutylaluminum chloride, isobutylaluminum dichloride, diethylaluminum hydride, ethylaluminum hydride, isobutyl aluminum hydride, di-isobutyl aluminum hydride and mixtures thereof;
wherein the electron donor is a compound selected from phosphate ester, ether, ketonic, anhydride, phenolic, amine, silane compounds, and mixtures thereof;
wherein the termination agent is a compound of selected from carbon monoxide, carbon dioxide, nitrogen, air, water, alcohol that contains 4-8 carbon atoms, acid that contains 4-8 carbon atoms, ketone that contains 4-8 carbon atoms, amine that contains 4-8 carbon atoms, hydroxybenzene that contains 4-8 carbon atoms, and mixtures thereof;
the mole ratio of termination agent to titanium and/or vanadium element within the primary catalyst is 1-200:1;
the antioxidant is a compound selected from N-Isopropyl-N?-phenyl-1,4-phenylenediamine, 2-Mercaptobenzimidazole, 2,2?-Methylenebis(6-tert-butyl-4-methylphenol), Butylated Hydroxytoluene, 2-Mercaptobenzimidazole zinc salt, Pentaerythritol tetrakis(3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate), Tris(2,4-di-tert-butylphenyl) phosphite, Distearyl thiodipropionate, Bis-(2,4-di-tert-butyl-pheny)-phosphiterythritol diphosphite, N-1,3-dimethylbutyl-N?-phenyl-p-phenylenediamine, n-Octadecyl 3-(3?,5?-di-t-butyl-4?-hydroxylphenyl)propionate, and mixtures thereof, and a weight ratio of antioxidant to copolymer rubber TBIR is 0.01-1:100; and
the rubber auxiliary agent is a compound selected from olefin, aromatic oil, naphthenic oil, C5 resin, octadecanoic acid, calcium stearate, dolomol, nihil album, silicon dioxide, carbon black modified derivatives of the aforementioned compounds, and mixtures thereof; and a weight ratio of the rubber auxiliary agent to copolymer rubber TBIR is 1-50:100;
wherein the method is conducted in a device comprising a recovery and refining unit, a polymerization unit, a post-treatment unit, and a utility unit;
the recovery and refining unit comprises:
the refining device, to refine the butadiene, isoprene and hydrogen, and comprises a treating column;
the separation device, to separate and recover unreacted butadiene and isoprene and transport them to the polymerization reactor or to the storage tank, the separation device comprising a recovery storage tank, a gas holder, and a separate column;
a storage and preparing unit for the cocatalyst, primary catalyst and electron donor;
the polymerization unit comprises:
the batching device, comprising a metering and pumping device for the butadiene monomers and isoprene monomers, a metering and pumping device for the primary catalyst, electron donor and cocatalyst, and a metering device for the hydrogen;
the polymerization apparatus, comprising a combination of a tank polymerization reactor and a horizontal reactor in series in that order; and
a monitor and control unit that comprises:
a temperature online monitor, a pressure online monitor, a material online detector, and a material online controller,
 the material online detector comprising an online viscosity detector and an online concentration detector,
 the material online controller comprising a material electromagnetic valve and a computer controller;
the post-treatment unit comprises:
the termination device comprising a double screw extruder;
the extrusion and devolatilization device comprising an extruder, a granulator, a drum wind dryer, and a vacuum pump, wherein the extrusion and devolatilization device removes the unreacted monomers and mixes the polymer with the antioxidant and/or rubber auxiliary agent, and then carries out the extrusion, granulation and drying of products produced by the mixing, extrusion, granulation and drying;
a preparing and conveying device of the termination agent;
a preparing and conveying device of the antioxidant;
a preparing and conveying device of the rubber auxiliary agent; and
a conveying, metering and packaging device of the polymer; and
the utility unit comprises:
a cold water, hot water and/or steam pipeline apparatus, for controlling the temperature of the polymerization device; and
a vacuum and high purity nitrogen apparatus that can replace the polymerization system before the polymerization and during overhaul.

US Pat. No. 10,988,556

CATIONIC POLYMERS AND POROUS MATERIALS

King Abdullah University ...

1. A porous material comprising:a zeolite core portion comprising a microporous structure comprising a plurality of micropores having a diameter of less than or equal to 2 nm, where the core portion comprises an aluminosilicate material, a titanosilicate material, or a pure silicate material;
a mesoporous zeolite shell portion that comprises an aluminosilicate material, a titanosilicate material, or a pure silicate material and surrounds the core portion, the shell portion comprising:
a microporous framework comprising a plurality of micropores having diameters of less than or equal to 2 nm; and
a plurality of mesopores having diameters of greater than 2 nm and less than or equal to 50 nm.

US Pat. No. 10,988,555

METHOD FOR SEPARATING HYDROCARBONS FROM POLYMER

BOREALIS AG, Vienna (AT)...

1. A flash separator comprisinga. an inlet located at an upper part of the flash separator for feeding a reaction solution into the flash separator,
b. optionally the inlet is circumvented with an outlet pipe,
c. a first outlet within a lower part of the flash separator, and
d. a second outlet within the upper part of the flash separator
wherein the inlet has a generally cylindrical wall that is perforated with multiple holes having a size of from 15 ?m to 1500 ?m.

US Pat. No. 10,988,554

ELIMINATION OF POLYMER FOULING IN FLUIDIZED BED GAS-PHASE FINES RECOVERY EDUCTORS

Chevron Phillips Chemical...

1. An eductor comprising:a first tubular body having a hollow interior and comprising:
a first inlet and a first outlet spaced apart from the first inlet along a central axis, and
a sidewall circumscribing the central axis and defining a mixing chamber; and
a second tubular body having a hollow interior and comprising a second inlet and a spaced apart second outlet, wherein the second tubular body extends into the mixing chamber through the sidewall of the first tubular body between the first inlet and the first outlet,
wherein the second tubular body comprises a bend of less than 90° toward the first outlet after extending into the mixing chamber.

US Pat. No. 10,988,553

CATALYST PRE-CONTACT DEVICE FOR CONTINUOUS POLYMERIZATION OF OLEFINS AND METHOD FOR CATALYST PRE-CONTACT

1. A catalyst pre-contact method for continuous polymerization of olefins, comprising:feeding a catalyst, a cocatalyst, and an optional external electron donor into a pre-contact device having a plurality of inlets and a plurality of outlets to conduct a pre-contact reaction at a pre-contact temperature in a range of from ?30° C. to 40° C. for a pre-contact time in a range of from 0.5 min to 70 min to obtain a pre-contact catalyst,
wherein the pre-contact time is adjusted by feeding the catalyst, the cocatalyst, and the optional external electron donor into one or more of the plurality of inlets in the pre-contact device or withdrawing a mixture containing the catalyst, the cocatalyst, and the optional external electron donor from one of the plurality of outlets so that a residence time of the mixture containing the catalyst, the cocatalyst, and the optional external electron donor in the pre-contact device changes accordingly; and
feeding the pre-contacted catalyst into a pre-polymerization system and then into a catalyst polymerization system, or
feeding the pre-contacted catalyst directly into a polymerization system.

US Pat. No. 10,988,531

CONJUGATES COMPRISING CELL-BINDING AGENTS AND CYTOTOXIC AGENTS

IMMUNOGEN, INC., Waltham...

1. A cell-binding agent-cytotoxic agent conjugate represented by the following structural formula:or a pharmaceutically acceptable salt thereof, wherein:CBA is an antibody having an aldehyde group covalently linked to the JCB? group;
JCB? is a moiety represented by
and is formed by reacting an aldehyde group on the CBA and an aldehyde reactive groupconnected to the group L, wherein the aldehyde group is located at the N-terminus of the antibody and is derived from oxidation of a 2-hydroxyethylamine moiety represented by the following structural formula:wherein the 2-hydroxyethylamine moiety being part of a serine residue;s1 is the site covalently linked to CBA; and s2 is the site covalently linked to the group L;
w is 1, 2, 3 or 4;
L-JD? is a bond; and D is represented by the following structural formula:

or a pharmaceutically acceptable salt thereof, wherein:
L? and L?? are both H; and L? is represented by the following formula:
s5—NR5—P—C(?O)—(CRaRb)r—Zd1—(CRaRb)r?—s6  (A);
s5 is the site covalently linked to the phenyl group on D; and s6 is the site covalently linked to JCB?;
Zd1 is absent, —C(?O)—NR9— or —NR9—C(?O)—;
P is a peptide containing between 2 to 5 amino acid residues;
Ra and Rb, for each occurrence, are independently —H, (C1-C3)alkyl or a charged substituent or an ionizable group Q;
r and r? are independently an integer from 1 to 6;
the double line between N and C represents a single bond or double bond, provided that when it is a double bond X is absent and Y is —H, and when it is a single bond, X is —H, Y is —OH or —SO3M;
R1, R2, R3, R4, R1?, R2?, R3? and R4? are all —H;
R5 and R9 are each independently H or Me;
R6 is —OMe;
X? and Y? are both —H;
A and A? are —O—; and
M is H+, Na+ or K+.

US Pat. No. 10,988,530

NOTCH INHIBITION IN THE TREATMENT AND PREVENTION OF NONALCOHOLIC FATTY LIVER DISEASE

1. A method of treating nonalcoholic fatty liver disease in a patient, comprising administering to said patient a therapeutically effective amount of a blocking antibody that inhibits the NOTCH signaling pathway, wherein said blocking antibody binds to Dll4 and inhibits its binding to a NOTCH-3 receptor.

US Pat. No. 10,988,523

MODIFIED LIPIDATED RELAXIN B CHAIN PEPTIDES AND THEIR THERAPEUTIC USE

SANOFI, Paris (FR)

1. A peptide having the following formula (I):Nter-Ac-(E)a-X10-E-G-R-E-X15-V-R-X18-X19-I-X21-X22-E-G-X25-S-X27-X28-X29-X30-R-(X32)b-(X33)c-(K)d-(X35)e-(gE)f-X37-Cter;
wherein:
Nter represents the N-terminal end of the peptide;
Cter represents the C-terminal end of the peptide;
a, b, c and d independently represent 0 or 1;
e and f independently represents 0, 1, 2, 3 or 4;
Ac represents acetyl group;
E represents glutamic acid;
X10 represents an amino acid selected from the group consisting of leucine,
2-amino-isobutyric acid, N?-acetyl-lysine and ?-methyl-leucine;
G represents glycine;
R represents arginine;
X15 represents an amino acid selected from the group consisting of lysine, homolysine, arginine, homoarginine and ornithine;
V represents valine;
X18 represents an amino acid selected from the group consisting of alanine, 2-amino-isobutyric acid, leucine, N?-acetyl-lysine, and glutamine;
X19 represents an amino acid selected from the group consisting of glutamine, N?-acetyl-lysine, citruline, alanine and 2-amino-isobutyric acid;
I represents isoleucine;
X21 represents an amino acid selected from the group consisting of alanine and 2-amino-isobutyric acid;
X22 represents an amino acid selected from the group consisting of isoleucine and 2-amino-isobutyric acid;
X25 represents an amino acid selected from the group consisting of methionine, norleucine, leucine, alanine, glutamine, N?-acetyl-lysine and glutamic acid;
S represents serine;
X27 represents an amino acid selected from the group consisting of threonine, lysine, arginine and glutamine;
X28 represents an amino acid selected from the group consisting of tryptophan, 5-fluoro-tryptophan, 5-chloro-tryptophan, 5-methoxy-tryptophan, tyrosine, phenylalanine, 4-fluoro-phenylalanine, 1-naphtylalanine, 2-naphtylalanine, ?-methyl-tryptophane, ?-methyl-phenylalanine and 5-hydroxy-tryptophane;
X29 represents an amino acid selected from the group consisting of serine, threonine, ?-methyl-serine, N?-acetyl-lysine and valine;
X30 represents an amino acid selected from the group consisting of lysine, 2-amino-isobutyric acid, ?-methyl-lysine, arginine and ?-methyl-arginine;
X31 represents an amino acid selected from the group consisting of arginine, N?-methyl-arginine, alanine, N?,N??-dimethyl-arginine and citruline;
X32 represents an amino acid selected from the group consisting of lysine, N?-acetyl-lysine, arginine, alanine and N?,N?,N?-tri-methyl-lysine;
X33 represents an amino acid selected from the group consisting of leucine, lysine, N?-acetyl-lysine, alanine and arginine;
K represents lysine;
X35 represents a polyethylene glycol derivative selected from the group consisting of PEG2, PEG4, PEG8, PEG2DGA, TTDS, PEG12, PEG24 and PEG8;
gE represents gamma-glutamic acid;
and
X37 represents the following structure:

in which:
-* represents a covalent bond: with (gE)f when f is different from 0; with (X35)e when f is 0 and e is different from 0; with (K)d when e and f are 0 and d is 1; with (X33)c when d, e and f are 0 and c is 1; with (X32)b when c, d, e and f are 0 and b is 1; or with X31 when b, c, d, e and f all are 0; and
Z represents a group of formula (II):
-[(PEGxx)g(gE)h(PEGxx)i(gE)JCk]
in which:
g and i independently represent 0, 1, 2, 3, 4 or 5;
h and j independently represent 0, 1, 2, 3, 4 or 5;
PEGxx independently represents a polyethylene glycol derivative selected from the group
consisting of PEG2, PEG2DGA, TTDS and PEG12; and
Ck represents a linear saturated C12—C22 acyl group;
or a salt or solvate thereof.

US Pat. No. 10,988,508

SYNTHETIC N-ACETYL-MURAMIC ACID DERIVATIVES AND USES THEREOF

University of Delaware, ...

1. An N-acetyl-muramic acid (NAM) derivative having formula I:
wherein Xa is selected from the group consisting of X22-X52 and X54-X59 as defined in table 1,
wherein Ya is selected from the group consisting of H, monophosphate, uridine diphosphate and ethyl azide linker prepared from 2-azido-ethanol, and
wherein Za is selected from the group consisting of OH, an ethylene diamine coupled fluorophore, a peptide and a peptide with an ethylene diamine coupled fluorophore, wherein the peptide is selected from the group consisting of a monopeptide, a dipeptide, a tripeptide and a pentapeptide.

US Pat. No. 10,988,506

CYCLIC TETRAPEPTIDE STEREOISOMERS

University of Kansas, La...

1. A method for treating and/or preventing depression or depression and anxiety, comprising administering to a subject a therapeutically effective amount of a pharmaceutical composition comprising:a therapeutically effective amount of a cyclic tetrapeptide comprising a structure of Formula 1 with an amino acid sequence of cyclo[Phe-Pro-Phe-Trp] (SEQ ID NO: 1), or a derivative thereof, wherein the cyclic tetrapeptide comprises an amino acid configuration selected from the group consisting of [LDDL], [DDLL], [DDDL], [DDLD], [LLLL], [LLDL], [DLLL], [DLDL], [LLLD], [LLDD], [DLDD], and [DLLD], and wherein the amino acid configuration of the cyclic tetrapeptide does not comprise [LDLL]; and

a pharmaceutically acceptable excipient or carrier.

US Pat. No. 10,988,503

SIX-MEMBERED RING-CONTAINING NUCLEOSIDE COMPOUND AND PREPARATION METHOD THEREOF

1. A six-membered ring-containing nucleoside compound, which is nucleoside compound 7 having the structural formula of:
where R1 is selected from the group consisting of

and R2 is hydroxy or alkynyl.

US Pat. No. 10,988,502

ALPHA-D-GALACTOSIDE INHIBITORS OF GALECTINS

GALECTO BIOTECH AB, Cope...

1. A D-galactopyranose compound of formula (1)whereinthe pyranose ring is a-D-galactopyranose,
R1 is a five or six membered heteroaromatic ring selected from the group consisting of formulas 2 to 9, wherein the asterix * indicates the carbon atom of the heteroaromatic ring that is covalently attached to the triazole group of formula (1):
wherein R2 to R23 and R27 are independently selected from H; halogen; OH; CN; SH; S—C1-3 alkyl; C1-3 alkyl, optionally substituted with a F; cyclopropyl, optionally substituted with a F; iso-propyl, optionally substituted with a F; O-cyclopropyl optionally substituted with a F; O-isopropyl optionally substituted with a F; OC1-3 alkyl optionally substituted with a F; NR24R25, wherein R24 is selected from H, and C1-3 alkyl, and R25 is selected from H, C1-3 alkyl, and COR26, wherein R26 is selected from H, and C1-3 alkyl;X is selected from S, SO, and SO2;B1 is selected from a) a C1-6 alkyl or branched C3-6 alkyl substituted with a five or six membered heteroaromatic ring, optionally substituted with a substituent selected from CN, a halogen, methyl optionally substituted with a F, OCH3 optionally substituted with a F, OCH2CH3 optionally substituted with a F, OH, and R27—CONH— wherein R27 is selected from C1-3 alkyl and cyclopropyl; or a C1-6 alkyl substituted with a phenyl, optionally substituted with a substituent selected from CN, a halogen, methyl optionally substituted with a F, OCH3 optionally substituted with a F, OCH2CH3 optionally substituted with a F, OH, and R28—CONH— wherein R28 is selected from C1-3 alkyl and cyclopropyl; b) an aryl, optionally substituted with a group selected from a halogen; CN; —COOH; —CONR29R30, wherein R29 and R30 are independently selected from H, C1-3 alkyl, cyclopropyl, and iso-propyl; C1-3 alkyl, optionally substituted with a F; cyclopropyl, optionally substituted with a F; isopropyl, optionally substituted with a F; OC1-3 alkyl, optionally substituted with a F; O-cyclopropyl, optionally substituted with a F; O-isopropyl, optionally substituted with a F; NR31R32, wherein R31 and R32 are independently selected from H, C1-3 alkyl and isopropyl; OH; and R33—CONH—, wherein R33 is selected from C1-3 alkyl and cyclopropyl; c) a C5-7 cycloalkyl, optionally substituted with a substituent selected from a halogen, CN, methyl optionally substituted with a F, OCH3 optionally substituted with a F, OCH2CH3 optionally substituted with a F, OH, and R34—CONH— wherein R34 is selected from C1-3 alkyl and cyclopropyl; and d) a heterocycle, optionally substituted with a group selected from a halogen; CN; —COOH; —CONR35R36, wherein R35 and R36 are independently selected from H, C1-3 alkyl, cyclopropyl, and iso-propyl; C1-3 alkyl, optionally substituted with a F; cyclopropyl, optionally substituted with a F; isopropyl, optionally substituted with a F; OC1-3 alkyl, optionally substituted with a F; O-cyclopropyl, optionally substituted with a F; O-isopropyl, optionally substituted with a F; NR37R38, wherein R37 and R38 are independently selected from H, C1-3 alkyl and isopropyl; OH; and R39—CONH— wherein R39 is selected from C1-3 alkyl and cyclopropyl; e) a C1-6 alkyl or branched C3-6 alkyl; ora pharmaceutically acceptable salt or solvate thereof.

US Pat. No. 10,988,501

REVERSIBLY BLOCKED NUCLEOSIDE ANALOGUES AND THEIR USE

MGI Tech Co., Ltd. BGI Sh...

1. A nucleoside analogue of the following formula:whereinR1 is a reversible blocking group selected from the group consisting of cyanoethenyl, allenyl, formaldehyde oximyl, acrylaldehyde oximyl, propionaldehyde oximyl, cyanoethenaldehyde oximyl, cis-cyanoethenyl, trans-cyanoethenyl, cis-cyanofluoroethenyl, trans-cyanofluoroethenyl, biscyanoethenyl, bisfluoroethenyl, cis-propenyl, trans-propenyl, nitroethenyl, acetoethenyl, methylcarbonoethenyl, amidoethenyl, methylsulfonoethenyl, methylsulfonoethyl, formimidate, formhydroxymate, vinyloethenyl, ethylenoethenyl, cyanoethylenyl, nitroethylenyl, amidoethylenyl,
wherein Ra is hydrogen, cyano, halogen, nitro, alkoxy, substituted or unsubstituted amino, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, or substituted or unsubstituted alkenyl; and Rb is hydrogen, substituted or unsubstituted alkyl, or substituted or unsubstituted alkoxy; andwherein Ra is hydrogen, cyano, halogen, nitro, alkoxy, substituted or unsubstituted amino, substituted or unsubstituted sulfonyl, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, and substituted or unsubstituted carbonyl;R2 comprises a nucleobase; and
R3 is a cleavable linking moiety comprising at least three phosphates, or analogues thereof.

US Pat. No. 10,988,498

PROCESSES AND INTERMEDIATES FOR THE PREPARATION OF 1?-SUBSTITUTED CARBA-NUCLEOSIDE ANALOGS

Gilead Sciences, Inc., F...

1. A compound that isor an acceptable salt thereof.

US Pat. No. 10,988,497

SYNTHESIS OF CYCLIC ORGANIC COMPOUNDS AND METALLOCENES

Univation Technologies, L...

1. A method of synthesizing a bicyclo[5.3.0]decene compound, the method comprising (A) contacting a compound of formula (1) (“compound (1)”):wherein R?1, R?2, R3, R3a, and R3b are independently H or (C1-C4)alkyl, or any two adjacent R1 to R3b groups are bonded together to form a (C1-C4)alkylene and the remaining two R1 to R3b groups independently are H or (C1-C4)alkyl, with a compound of formula (2) (“compound (2)”):wherein R4 is H or (C1-C4)alkyl, in the presence of an effective amount of a phosphoric and/or sulfonic acid reagent and under reaction conditions sufficient to make a compound of formula (3) (“compound (3)”):and/or its oxo/R4 regioisomer; wherein R1 to R4 are as defined above; wherein the phosphoric and/or sulfonic acid reagent is a mixture of a phosphorous pentoxide and methanesulfonic acid (“P2O5/H3CSO3H mixture”), or a reaction product thereof; and with the proviso that the phosphoric and/or sulfonic acid reagent and contacting step (A) are free of a polyphosphoric acid (PPA);(B) contacting the compound (3) and/or its oxo/R4 regioisomer with either a hydride-functional reducing agent or a (C1-C4)alkyl lithium, under reaction conditions sufficient to make a compound of formula (4) (“compound (4)”):
and/or its (HO,R5)/R4 regioisomer, respectively, wherein R1 to R4 are as defined above and R5 is either H or (C1-C4)alkyl, respectively; and (C) contacting the compound (4) and/or its (HO,R5)/R4 regioisomer with dehydration reaction conditions to make a compound of formula (5) (“compound (5)”):and/or its R5/R4 regioisomer, respectively; wherein R1 to R5 are as defined above; andfurther comprising synthesizing a zirconocene dichloride complex, comprising (D) contacting the compound (5) and/or its R5/R4 regioisomer with an alkyl lithium under reaction conditions sufficient to make a compound of formula (6) (“compound (6)”):
and/or its R5/R4 regioisomer, wherein R1 to R5 are as defined above; and (E) contacting the compound (6) and/or its R5/R4 regioisomer with a compound of formula (7) (“compound (7)”):wherein R6 to R8 independently are H or (C1-C4)alkyl and R9 and R10 independently are H, (C1-C4)alkyl, under reaction conditions sufficient to make a compound of formula (8) (“compound (8)”):and/or its R5/R4 regioisomer, wherein R1 to R10 are as defined above.

US Pat. No. 10,988,495

ORGANOMETALLIC COMPOUND, ORGANIC-LIGHT EMITTING DEVICE INCLUDING THE SAME, AND DIAGNOSTIC COMPOSITION INCLUDING THE ORGANOMETALLIC COMPOUND

SAMSUNG ELECTRONICS CO., ...

1. An organometallic compound represented by Formula 1:

wherein
M in Formula 1 is beryllium (Be), magnesium (Mg), aluminum (Al), calcium (Ca), titanium (Ti), manganese (Mn), cobalt (Co), copper (Cu), zinc (Zn), gallium (Ga), germanium (Ge), zirconium (Zr), ruthenium (Ru), rhodium (Rh), palladium (Pd), silver (Ag), rhenium (Re), platinum (Pt), or gold (Au),
in Formula 1, two bonds selected from a bond between A1 and M, a bond between A2 and M, a bond between A3 and M, and a bond between A4 and M are each a covalent bond, and the others thereof are each a coordinate bond,
A1 in Formula 1 is represented by Formula A1-1 or A1-2, and in Formulae A1-1 and A1-2, * indicates a binding site to M in Formula 1, and *? indicates a binding site to T1 in Formula 1,
A2 in Formula 1 is represented by one of Formula A2-1 to A2-3, and in Formulae A2-1 to A2-3, * indicates a binding site to M in Formula 1, *? indicates a binding site to T1 in Formula 1, and *? indicates a binding site to T2 in Formula 1, and in Formula A2-1, the two atoms to which *? and *? are linked are adjacent to X2,
A3 in Formula 1 is represented by one of Formula A3-1 to A3-3, and in Formulae A3-1 to A3-3, * indicates a binding site to M in Formula 1, *? indicates a binding site to T2 in Formula 1, and *? indicates a binding site to T3 in Formula 1, and in Formula A3-1, the two atoms to which *? and *? are linked are adjacent to X3,
A4 in Formula 1 is a first atom linked to M or a non-cyclic moiety comprising the first atom linked to M, or is represented by Formula A4-1 or A4-2, and in Formulae A4-1 and A4-2, * indicates a binding site to M in Formula 1, and *? indicates a binding site to T3 in Formula 1, and in Formula A4-1, the atom to which *? is linked is adjacent to X4,
the first atom is B, N, P, C, Si, O, or S,
in Formulae A1-1, A1-2, A2-1 to A2-3, A3-1 to A3-3, A4-1, and A4-2, X1 to X4 and Y1 to Y10 are each independently C or N, and Y11 and Y12 are each independently O, S, N, C, or Si,
ring CY1 in Formulae A1-1 and A1-2 is a 5-membered ring,
rings CY2 to CY6 in Formulae A1-1, A1-2, A2-1 to A2-3, A3-1 to A3-3, A4-1, and A4-2 are each independently a C5-C30 carbocyclic group or a C1-C30 heterocyclic group,
T1 to T3 in Formula 1 are each independently selected from a single bond, a double bond, *—N(R7)—*?, *—B(R7)—*?, *—P(R7)—*?, *—C(R7)(R8)—*?, *—Si(R7)(R8)—*?, *—Ge(R7)(R8)—*?, *—S—*?, *—Se—*?, *—O—*?, *—C(?O)—*?, *—S(?O)—*?, *—S(?O)2—*?, *—C(R7)?*?, *?C(R7)—*?, *—C(R7)?C(R8)—*?, *—C(?S)—*?, and *—C?C—*?,
R7 and R8 are optionally linked via a single bond, a double bond, or a first linking group to form a substituted or unsubstituted C5-C30 carbocyclic group or a substituted or unsubstituted C1-C30 heterocyclic group,
R1 to R8 are each independently selected from hydrogen, deuterium, —F, —Cl, —Br, —I, —SF5, a hydroxyl group, a cyano group, a nitro group, an amidino group, a hydrazine group, a hydrazone group, a carboxylic acid group or a salt thereof, a sulfonic acid group or a salt thereof, a phosphoric acid group or a salt thereof, a substituted or unsubstituted C1-C60 alkyl group, a substituted or unsubstituted C2-C60 alkenyl group, a substituted or unsubstituted C2-C60 alkynyl group, a substituted or unsubstituted C1-C60 alkoxy group, a substituted or unsubstituted C3-C10 cycloalkyl group, a substituted or unsubstituted C1-C10 heterocycloalkyl group, a substituted or unsubstituted C3-C10 cycloalkenyl group, a substituted or unsubstituted C1-C10 heterocycloalkenyl group, a substituted or unsubstituted C6-C60 aryl group, a substituted or unsubstituted C6-C60 aryloxy group, a substituted or unsubstituted C6-C60 arylthio group, a substituted or unsubstituted C7-C60 arylalkyl group, a substituted or unsubstituted C1-C60 heteroaryl group, a substituted or unsubstituted C1-C60 heteroaryloxy group, a substituted or unsubstituted C1-C60 heteroarylthio group, a substituted or unsubstituted C2-C60 heteroarylalkyl group, a substituted or unsubstituted monovalent non-aromatic condensed polycyclic group, a substituted or unsubstituted monovalent non-aromatic condensed heteropolycyclic group, —N(Q1)(Q2), —Si(Q3)(Q4)(Q5), —B(Q6)(Q7), and —P(?O)(Q8)(Q9),
a1 in Formula A1-1 is an integer from 0 to 4,
a2 to a6 in Formulae A1-1, A1-2, A2-1 to A2-3, A3-1 to A3-3, A4-1, and A4-2 are each independently an integer from 0 to 20,
two of a plurality of neighboring groups R2 are optionally linked to form a substituted or unsubstituted C5-C30 carbocyclic group or a substituted or unsubstituted C1-C30 heterocyclic group,
two of a plurality of neighboring groups R3 are optionally linked to form a substituted or unsubstituted C5-C30 carbocyclic group or a substituted or unsubstituted C1-C30 heterocyclic group,
two of a plurality of neighboring groups R4 are optionally linked to form a substituted or unsubstituted C5-C30 carbocyclic group or a substituted or unsubstituted C1-C30 heterocyclic group,
two of a plurality of neighboring groups R5 are optionally linked to form a substituted or unsubstituted C5-C30 carbocyclic group or a substituted or unsubstituted C1-C30 heterocyclic group,
two of a plurality of neighboring groups R6 are optionally linked to form a substituted or unsubstituted C5-C30 carbocyclic group or a substituted or unsubstituted C1-C30 heterocyclic group,
two or more neighboring groups selected from R2 to R5 are optionally linked to form a substituted or unsubstituted C5-C30 carbocyclic group or a substituted or unsubstituted C1-C30 heterocyclic group,
A1 and A4 in Formula 1 are not linked to each other,
i) when A1 in Formula 1 is represented by Formula A1-1, the organometallic compound represented by Formula 1 satisfies “Condition 1”, and ii) when A1 in Formula 1 is represented by Formula A1-2, the organometallic compound represented by Formula 1 satisfies at least one of “Condition 1” to “Condition 3”,
“Condition 1”
A2 in Formula 1 is represented by Formula A2-2 or A2-3,
“Condition 2”
A3 in Formula 1 is represented by Formula A3-2 or A3-3, and
“Condition 3”
A4 in Formula 1 is represented by Formula A4-2,
wherein at least one substituent of the substituted C5-C30 carbocyclic group, the substituted C1-C30 heterocyclic group, the substituted C1-C60 alkyl group, the substituted C2-C60 alkenyl group, the substituted C2-C60 alkynyl group, the substituted C1-C60 alkoxy group, the substituted C3-C10 cycloalkyl group, the substituted C1-C10 heterocycloalkyl group, the substituted C3-C10 cycloalkenyl group, the substituted C1-C10 heterocycloalkenyl group, the substituted C6-C60 aryl group, the substituted C6-C60 aryloxy group, the substituted C6-C60 arylthio group, the substituted C7-C60 arylalkyl group, the substituted C1-C60 heteroaryl group, the substituted C1-C60 heteroaryloxy group, the substituted C1-C60 heteroarylthio group, the substituted C2-C60 heteroarylalkyl group, the substituted monovalent non-aromatic condensed polycyclic group, and the substituted monovalent non-aromatic condensed heteropolycyclic group is selected from:
deuterium, —F, —Cl, —Br, —I, —CD3, —CD2H, —CDH2, —CF3, —CF2H, —CFH2, a hydroxyl group, a cyano group, a nitro group, an amidino group, a hydrazine group, a hydrazone group, a carboxylic acid group or a salt thereof, a sulfonic acid group or a salt thereof, a phosphoric acid group or a salt thereof, a C1-C60 alkyl group, a C2-C60 alkenyl group, a C2-C60 alkynyl group, and a C1-C60 alkoxy group;
a C1-C60 alkyl group, a C2-C60 alkenyl group, a C2-C60 alkynyl group, and a C1-C60 alkoxy group, each substituted with at least one selected from deuterium, —F, —Cl, —Br, —I, —CD3, —CD2H, —CDH2, —CF3, —CF2H, —CFH2, a hydroxyl group, a cyano group, a nitro group, an amidino group, a hydrazine group, a hydrazone group, a carboxylic acid group or a salt thereof, a sulfonic acid group or a salt thereof, a phosphoric acid group or a salt thereof, a C3-C10 cycloalkyl group, a C1-C10 heterocycloalkyl group, a C3-C10 cycloalkenyl group, a C1-C10 heterocycloalkenyl group, a C6-C60 aryl group, a C6-C60 aryloxy group, a C6-C60 arylthio group, a C7-C60 arylalkyl group, a C1-C60 heteroaryl group, a C1-C60 heteroaryloxy group, a C1-C60 heteroarylthio group, a C2-C60 heteroarylalkyl group, a monovalent non-aromatic condensed polycyclic group, a monovalent non-aromatic condensed heteropolycyclic group, —N(Q11)(Q12), —Si(Q13)(Q14)(Q15), —B(Q16)(Q17), and —P(?O)(Q18)(Q19);
a C3-C10 cycloalkyl group, a C1-C10 heterocycloalkyl group, a C3-C10 cycloalkenyl group, a C1-C10 heterocycloalkenyl group, a C6-C60 aryl group, a C6-C60 aryloxy group, a C6-C60 arylthio group, a C7-C60 arylalkyl group, a C1-C60 heteroaryl group, a C1-C60 heteroaryloxy group, a C1-C60 heteroarylthio group, a C2-C60 heteroarylalkyl group, a monovalent non-aromatic condensed polycyclic group, and a monovalent non-aromatic condensed heteropolycyclic group;
a C3-C10 cycloalkyl group, a C1-C10 heterocycloalkyl group, a C3-C10 cycloalkenyl group, a C1-C10 heterocycloalkenyl group, a C6-C60 aryl group, a C6-C60 aryloxy group, a C6-C60 arylthio group, a C7-C60 arylalkyl group, a C1-C60 heteroaryl group, a C1-C60 heteroaryloxy group, a C1-C60 heteroarylthio group, a C2-C60 heteroarylalkyl group, a monovalent non-aromatic condensed polycyclic group, and a monovalent non-aromatic condensed heteropolycyclic group, each substituted with at least one selected from deuterium, —F, —Cl, —Br, —I, —CD3, —CD2H, —CDH2, —CF3, —CF2H, —CFH2, a hydroxyl group, a cyano group, a nitro group, an amidino group, a hydrazine group, a hydrazone group, a carboxylic acid group or a salt thereof, a sulfonic acid group or a salt thereof, a phosphoric acid group or a salt thereof, a C1-C60 alkyl group, a C2-C60 alkenyl group, a C2-C60 alkynyl group, a C1-C60 alkoxy group, a C3-C10 cycloalkyl group, a C1-C10 heterocycloalkyl group, a C3-C10 cycloalkenyl group, a C1-C10 heterocycloalkenyl group, a C6-C60 aryl group, a C6-C60 aryloxy group, a C6-C60 arylthio group, a C7-C60 arylalkyl group, a C1-C60 heteroaryl group, a C1-C60 heteroaryloxy group, a C1-C60 heteroarylthio group, a C2-C60 heteroarylalkyl group, a monovalent non-aromatic condensed polycyclic group, a monovalent non-aromatic condensed heteropolycyclic group, —N(Q21)(Q22), —Si(Q23)(Q24)(Q25), —B(Q26)(Q27), and —P(?O)(Q28)(Q29); and
N(Q31)(Q32), —Si(Q33)(Q34)(Q35), —B(Q36)(Q37), and —P(?O)(Q38)(Q39), and
Q1 to Q9, Q11 to Q19, Q21 to Q29, and Q31 to Q39 are each independently selected from hydrogen, deuterium, —F, —Cl, —Br, —I, a hydroxyl group, a cyano group, a nitro group, an amidino group, a hydrazine group, a hydrazone group, a carboxylic acid group or a salt thereof, a sulfonic acid group or a salt thereof, a phosphoric acid group or a salt thereof, a C1-C60 alkyl group, a C1-C60 alkyl group substituted with at least one selected from deuterium, a C1-C60 alkyl group, and a C6-C60 aryl group, a C2-C60 alkenyl group, a C2-C60 alkynyl group, a C1-C60 alkoxy group, a C3-C10 cycloalkyl group, a C1-C10 heterocycloalkyl group, a C3-C10 cycloalkenyl group, a C1-C10 heterocycloalkenyl group, a C6-C60 aryl group, a C6-C60 aryl group substituted with at least one selected from deuterium, a C1-C60 alkyl group, and a C6-C60 aryl group, a C6-C60 aryloxy group, a C6-C60 arylthio group, a C7-C60 arylalkyl group, a C1-C60 heteroaryl group, a C1-C60 heteroaryloxy group, a C1-C60 heteroarylthio group, a C2-C60 heteroarylalkyl group, a monovalent non-aromatic condensed polycyclic group, and a monovalent non-aromatic condensed heteropolycyclic group.

US Pat. No. 10,988,494

EUROPIUM COMPLEX

TOSOH CORPORATION, Shuna...

1. A europium complex expressed with the following formula (A):
wherein RA and RB independently represent a cyclic alkyl group with 3 to 10 carbons, respectively, and Rc is a cyclic alkyl group with 3 to 10 carbons, or a phenyl group expressed with the formula (B):

wherein XA, XB, XC, XD and XE independently represent a hydrogen atom, a fluorine atom, an alkyl group with 1 to 3 carbons, an alkyloxy group with 1 to 3 carbons, an aryloxy group with 6 to 10 carbons, a fluoroalkyl group with 1 to 3 carbons, a fluoroalkyloxy group with 1 to 3 carbons, or a phenyl group that may be substituted with a fluorine atom, an alkyl group with 1 to 3 carbons, an alkyloxy group with 1 to 3 carbons, a fluoroalkyl group with 1 to 3 carbons, a fluoroalkyloxy group with 1 to 3 carbons, a fluorophenyl group, a hydroxyl group or a cyano group, respectively, or
wherein RA is cyclic alkyl group with 3 to 10 carbons, RB and Rc are a phenyl group expressed with the formula (B), provided, however, that a case where RA is a cyclohexyl group, and, RB and RC are a phenyl group is excluded; or
wherein RA, RB and Rc are independently an ortho-substituted phenyl group expressed with the formula (Ba):

wherein XF represents a hydrogen atom, an alkyl group with 1 to 3 carbons, an alkyloxy group with 1 to 3 carbons, a fluoroalkyl group with 1 to 3 carbons, a fluoroalkyloxy group with 1 to 3 carbons, a naphthyl group that may be substituted with a fluorine atom, a pyridyl group that may be substituted with a fluorine atom, or a phenyl group expressed with the formula (C):

wherein ZA, ZC and ZE independently represent a hydrogen atom, a fluorine atom, an alkyl group with 1 to 3 carbons, an alkyloxy group with 1 to 3 carbons, an aryloxy group with 6 to 10 carbons, a fluoroalkyl group with 1 to 3 carbons, a fluoroalkyloxy group with 1 to 3 carbons, a phenyl group that may be substituted with a fluorine atom, a hydroxyl group or a cyano group, respectively;
wherein ZB and ZD are independently a hydrogen atom or fluorine atom, respectively, provided, however that a case where RA, RB and RC are all a phenyl group is excluded;
wherein RD represents a hydrogen atom, a deuterium atom or a fluorine atom;
wherein WA and WB independently an alkyl group with 1 to 6 carbons, a fluoroalkyl group with 1 to 6 carbons, a phenyl group, a 2-thienyl group or a 3-thienyl group, respectively; and
wherein n represents an integer of 1 to 3.

US Pat. No. 10,988,493

ORGANIC SILICON COMPOUND, AND ADDITIVE FOR RUBBER AND RUBBER COMPOSITION USING SAME

SHIN-ETSU CHEMICAL CO., L...

1. A rubber compounding ingredient comprising an organosilicon compound having formula (1) having a number-average molecular weight of 10,500 to 40,000,
wherein each R1 is independently an alkyl group of 1 to 10 carbon atoms or an aryl group of 6 to 10 carbon atoms, each R2 is independently an alkyl group of 1 to 10 carbon atoms or an aryl group of 6 to 10 carbon atoms, f is a number of 0 or more, e, g and h are each independently a number larger than 0, and m is an integer from 1 to 3, with the proviso that individual recurring units are arranged in any order, and
a sulfide group-containing organosilicon compound.

US Pat. No. 10,988,492

LOW-VISCOSITY CROSSLINKERS CONTAINING ALKOXYSILANE GROUPS

Evonik Operations GmbH, ...

1. A crosslinker of formula (I) or a mixture of at least two crosslinkers of formula (I)
wherein R1 and R2 are each independently selected from the group consisting of H, —(CH2)rR4, with r=0 to 12, —OR5, and —NHR5,
wherein R4 and R5 are each independently selected from the group consisting of H, an alkyl group optionally containing a heteroatom, and having 1 to 18 carbon atoms, a cycloalkyl group optionally containing a heteroatom, and having 3 to 18 carbon atoms, an alkylaryl group optionally containing a heteroatom, and having 6 to 18 carbon atoms, a bivalent alkylene group having 1 to 10 carbon atoms, an alkylene oxide group having at least 4 carbon atoms, a polyether group, a polyhydroxy-functional group having 1 to 18 carbon atoms, a heteroaromatic group containing —O— and/or N- and having 5 to 18 carbon atoms and an —O— or NH-polyether group containing one or more different polyglycol units (CH2CH2O)pR?, wherein p is 4 to 20 and R? is an alkyl radical having 1 to 18 carbon atoms or H, and
wherein each G1 is a group of formula (IIa)
—(C?O)—NH—R—Si(OR?)3  (IIa),
wherein R in formula (IIa) is independently an aliphatic (cyclo)alkylene radical having 1 to 10 carbon atoms, and R? in formula (IIa) in each case independently represents a linear, branched or cyclic alkyl radical having 1 to 10 carbon atoms, wherein a) in the crosslinker of formula (I) at least one of R1 and R2 is selected from —OR5, wherein R5 is as defined above, or b) in the crosslinker of formula (I) R1 and R2 are selected from —OR5, wherein R5 is as defined above.

US Pat. No. 10,988,491

DEGRADABLE POLYMERS OF A CYCLIC SILYL ETHER AND USES THEREOF

Massachusetts Institute o...

1. A compound of Formula (B):or a salt thereof; whereinY is O or C(RQ)2;
each instance of RQ is independently hydrogen, halogen, or substituted or unsubstituted, C1-6alkyl;
j is 1, 2, or 3; k is 2 or 3; the first instance of RK is hydrogen, halogen, unsubstituted C1-3 alkyl, substituted or unsubstituted n-butyl, substituted or unsubstituted sec-butyl, substituted or unsubstituted iso-butyl, substituted or unsubstituted, C5-10 alkyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted aryl, substituted or unsubstituted heteroaryl, or —ORN; the second instance of RK is hydrogen, halogen, substituted or unsubstituted, C1-10 alkyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, or —ORN; and each instance of RN is independently hydrogen, substituted or unsubstituted acyl, substituted or unsubstituted, C1-10 alkyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, or an oxygen protecting group;
or: j is 1; k is 1; the first instance of RK is halogen, unsubstituted ethyl, substituted or unsubstituted n-butyl, substituted or unsubstituted sec-butyl, substituted or unsubstituted iso-butyl, substituted or unsubstituted, C5-10 alkyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted aryl, substituted or unsubstituted heteroaryl, or —ORN; the second instance of RK is hydrogen, halogen, unsubstituted C1 alkyl, substituted or unsubstituted, C2-10 alkyl, substituted or unsubstituted carbocyclyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, or —ORN; and each instance of RN is independently hydrogen, substituted or unsubstituted acyl, unsubstituted methyl, substituted or unsubstituted, C3-10 alkyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl.

US Pat. No. 10,988,489

ORGANOBORANES USEFUL AS ELECTROLYTES FOR LITHIUM BATTERIES

Clark Atlanta University,...

1. A compound of Formula (I), (II), or (III), wherein the Formula (I), (II), (III) compounds have the following structures
wherein
R1, R2, and R3 are independently selected from H, C1-C3alkyl, allyl, cyano, amino, hydroxyl, —CO2H, —CO2R?? and —OCOOR??; m, m? and m? are integers, each independently selected from 3 to 100; n, n?, and n? are integers, each independently selected from 1 to 100; and R?? is C1-C6alkyl or aryl.

US Pat. No. 10,988,488

PROCESS FOR THE FUNCTIONALIZATION OF SP2-H CARBONS USING FRUSTRATED LEWIS PAIR CATALYSTS

9. A catalytic process for the dehydrogenative functionalization of a sp2 carbon, the process comprising:contacting a compound of Formula I:

wherein:
A is N;
M is B;
R1 and R2 are independently hydrogen, C1-15 alkyl, C4-15branched alkyl, C6-18aryl, C6-18aryl having at least one C1-10 alkyl substituent, C5-8cycloalkyl; C5-8cycloalkyl having at least one C1-10 alkyl substituent; or
R1 and R2 are linked together to form a nitrogen containing ring system, wherein the nitrogen containing ring system may further comprise at least one heteroatom selected from nitrogen, oxygen and sulfur, and wherein the nitrogen containing ring system is optionally substituted by one or more C1-10 alkyl groups;
R3 and R4 are independently hydrogen, halogen, C1-15 alkyl, C4-15branched alkyl, C6-18aryl, C6-18aryl having at least one substituent chosen from halogen and C1-10 alkyl, C5-8cycloalkyl;
C5-8cycloalkyl having at least one C1-10 alkyl substituent, OR6; or
R3 and R4 are linked together to form a boron containing ring system, wherein the boron containing ring system may further comprise at least one heteroatom selected from nitrogen, oxygen and sulfur, and wherein the boron containing ring system is optionally substituted by one or more C1-10 alkyl groups;
R5 is hydrogen, C1-15 alkyl, OR6, and halogen;
R6 is C1-15 alkyl;
L is a heteroarene, arene, or a carbon chain (C1 trough C20) which can be linear, cyclic or branched and may comprise heteroatoms, with the proviso that A and M are in a vicinal position relative to each other; or
L is a polymer comprising monomeric repeating units having an aryl group, with the proviso that A and M are in a vicinal position relative to each other on the aryl groups;
a functionalization reagent; and
a substrate comprising a sp2-H carbon;
under conditions to provide a substrate comprising a functionalized sp2 carbon; wherein the functionalization reagent is an organoborane reagent.

US Pat. No. 10,988,484

GLUCOSE UPTAKE INHIBITORS

Kadmon Corporation, LLC, ...

1. A compound having the formula I:or a pharmaceutically acceptable salt thereof,wherein:A is a group having the formula:

Ring B is a five- or six-membered ring containing 1 or 2 heteroatoms selected from the group consisting of N, O and S;
Ring C is a five- or six-membered aryl or heteroaryl ring containing from 0 to 2 heteroatoms selected from the group consisting of N, O and S;
each R1 is independently selected from the group consisting of halo, C1-C6 alkyl, C2-C6 alkenyl, C1-C6 alkoxy, C3-C6 cycloalkyl, oxo, hydroxy, amino, cyano and C1-C3 perfluoro alkyl;
n is selected from 0, 1, or 2;
each R2 is independently selected from the group consisting of halo, C1-C6 alkyl, C2-C6 alkenyl, C1-C6 alkoxy, C3-C6 cycloalkyl, oxo, hydroxy, amino, cyano and C1-C3 perfluoro alkyl;
m is selected from 0, 1, or 2;
R3 and R4 are H;
D is selected from the group consisting of —O—(CH2)y—C(?O)NR5R6, —O—C(?O)—(CH2)y—NR5R6, —O—(CH2)y—NR5R6, —NH—C(?O)—(CH2)y—NR5R6, —NH—C(?O)—(CH2)y—R7, and —NH—(CH2)y—NR5R6;
y is selected from 1, 2, or 3;
R5 and R6 are independently selected from the group consisting of H, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, —(C1-C6 alkyl)-O—(C1-C6 alkyl), aryl, aralkyl, heteroaryl, and C3-C6 cycloalkyl,
or R5 and R6 may be taken together with the nitrogen to which they are attached to form a 5- to 6-membered heterocyclic ring having up to 3 heteroatoms selected from N, O, and S, and which is optionally substituted by from 1 to 3 substituents independently selected from halo, C1-C6 alkyl, C2-C6 alkenyl, C1-C6 alkoxy, C3-C6 cycloalkyl, oxo, hydroxy, amino, cyano and C1-C3 perfluoro alkyl; and
R7 is selected from the group consisting of aryl, heteroaryl, and a hetercyclic group.

US Pat. No. 10,988,482

IRAK4 INHIBITOR AND USE THEREOF

BEIJING HANMI PHARMACEUTI...

1. A compound which has a structural formula I
wherein:
Y is O, S, SO, SO2, or NR1;
Z is S or NR2;
A is phenyl or heteroaryl, optionally substituted with one or more R4 groups;
B is C3-8 cycloalkyl substituted with one or more R3 groups;
R1 is hydrogen or C1-6 alkyl;
R2 is hydrogen, C1-6 alkyl, hydroxyC1-6alkyl, cyanoC1-6alkyl, alkoxyC1-6alkyl, C1-6 alkoxycarbonylC1-6alkyl, aminoacylC1-6alkyl, C1-6alkylaminoacylC1-6alkyl, diC1-6alkylaminoacylC1-6 alkyl, heterocyclylC1-6alkyl, C6-10arylC1-6alkyl, or heteroarylC1-6alkyl;
each R3 is independently C2-6 alkyl, heterocyclyl, hydroxy, R3aR3bN—, carboxy, haloC1-6 alkyl, hydroxyC1-6alkyl, C1-6 alkoxy, heterocyclyloxy, heterocyclylC1-6alkyloxy, hydroxyC1-6 alkyloxy, or R3aR3bNC(?O)—, wherein said heterocyclyl, at each occurrence, is optionally substituted with one or more substituents selected from the group consisting of halogen, C1-6 alkyl, haloC1-6alkyl, hydroxy, C1-6 alkoxy, amino, C1-6 alkylamino, and diC1-6alkylamino; and
each of R3a and R3b is independently hydrogen, C1-6 alkyl, C3-8 cycloalkyl, hydroxyC1-6alkyl, heterocyclyl, C6-10 aryl, or heteroaryl, wherein said C3-8 cycloalkyl, heterocyclyl, C6-10 aryl, or heteroaryl is optionally substituted with one or more substituents selected from the group consisting of halogen, C1-6 alkyl, haloC1-6alkyl, hydroxy, C1-6 alkoxy, amino, C1-6 alkylamino, and diC1-6 alkylamino,
each R4 is independently halogen, hydroxyl, nitro, R4aR4bN—, cyano, C1-6alkyl, C3-8 cycloalkyl, heterocyclyl, C6-10 aryl, heteroaryl, hydroxyC1-6alkyl, C1-6alkoxyC1-6alkyl, heterocyclylC1-6alkyl, aminoacylC1-6alkyl, C1-6 alkoxy, C3-8 cycloalkyloxy, heterocyclyloxy, aminoC3-8cycloalkyloxy, C1-6alkylcarbonyl, C3-8cycloalkylcarbonyl, heterocyclylcarbonyl, heterocyclylC1-6alkylcarbonyl, or R4aR4bNC(?O)—, wherein said C3-8 cycloalkyl, heterocyclyl, C6-10 aryl, or heteroaryl, at each occurrence, is independently optionally substituted with one or more substituents selected from the group consisting of halogen, C1-6 alkyl, haloC1-6alkyl, hydroxy, C1-6 alkoxy, amino, C1-6 alkylamino, diC1-6alkylamino, C1-6alkylcarbonyl, and heterocyclyl; and
each of R4a and R4b is independently hydrogen, C1-6 alkyl, C3-8 cycloalkyl, hydroxyC1-6alkyl, C1-6alkyloxyC1-6alkyl, heterocyclylC1-6alkyl, heterocyclyl, C6-10 aryl, or heteroaryl, wherein said C3-8 cycloalkyl, heterocyclyl, C6-10 aryl, or heteroaryl, at each occurrence, is independently optionally substituted with one or more substituents selected from the group consisting of halogen, C1-6 alkyl, haloC1-6alkyl, hydroxy, C1-6 alkyloxy, amino, C1-6 alkylamino, diC1-6alkylamino, and C1-6 alkylcarbonyl,
wherein heterocyclyl, at each occurrence, is a 5- to 6-membered heterocyclyl group containing 1 to 2 heteroatoms selected from the group consisting of nitrogen, oxygen and sulfur; and heteroaryl, at each occurrence, is a 5- to 6-membered heteroaryl group containing 1 to 2 heteroatoms selected from the group consisting of nitrogen, oxygen and sulfur, or a stereoisomer, tautomer, solvate, or a pharmaceutically acceptable salt thereof.

US Pat. No. 10,988,478

PYRAZOLO[1,5A]PYRIMIDINE DERIVATIVES AS IRAK4 MODULATORS

Genentech, Inc., South S...

1. A compound of Formula 0:
or a stereoisomer or pharmaceutically acceptable salt thereof, wherein:
R1 is hydrogen or halogen;
R3 is halogen, CN, C1-3alkyl, C2-3alkenyl, C3-7cycloalkyl group, C1-C3alkanoyl, —(C0-C3alkyl)C(O)NR6R7, —(C2-3alkenyl)C(O)NR6R7, —S(O)1-2NR6R7, —NR8R9, —O—C1-3alkyl, a 3-7 membered monocyclic saturated or partially saturated heterocyclic group, a 5-6 membered monocyclic heteroaryl ring, or a 5-6 membered monocyclic aryl ring, Br, Cl, F, OCHF2, CHF2, or CF3, cyclopropyl, azetidinyl, CN, —C(O)CH3, —C(O)NH2, —C(O)NHCH3, —NHCH3, —SO2—NH2, or —SO2—NHCH3;
wherein any alkyl, alkanoyl, or alkenyl is independently optionally substituted by halogen, oxo, CN, OH, C1-3alkoxy, or C1-3haloalkoxy, and
wherein any cycloalkyl group, heterocyclic group, heteroaryl ring, or aryl ring is independently optionally substituted by halogen, oxo, CN, OH, C1-3alkyl, or C1-3haloalkyl;
R4 is hydrogen, halogen, C1-3alkyl, C2-3alkenyl, —(C0-C3alkyl)C(O)R13, —(C2-3alkenyl)C(O)NR10R11, —S(O)1-2NR10R11, a 3-7 membered monocyclic saturated or partially saturated heterocyclic group, —C(O)NR8R9, or —NR8R9,
wherein any alkyl, alkenyl, or heterocyclic group is independently optionally substituted by halogen, oxo, CN, OH, C1-3alkoxy, C1-3haloalkoxy, or a 3-7 membered monocyclic saturated or partially saturated heterocyclic group that may be optionally substituted with oxo;
R5 is hydrogen, —CN, C1-6alkyl, C1-6alkoxy, C3-10cycloalkyl group, —NR8R9, —C(O)NR8R9, —O(C3-7cycloalkyl group), —O(C1-3alkyl)-3-8 membered cycloalkyl group, —O(C0-3alkyl)-3-8 membered saturated or partially saturated heterocyclic group, —O(C1-3alkyl)-phenyl, a —O(C1-3alkyl)-5-6 membered heteroaryl ring, a 3-11 membered saturated or partially saturated heterocyclic group, or a 5-6 membered monocyclic heteroaryl ring,
wherein any alkyl or alkoxy is independently optionally substituted by halogen, oxo, CN, OH, C1-3alkoxy, C1-3haloalkoxy, or a 3-11 membered saturated or partially saturated heterocyclic group that may be optionally substituted with (i) —C(O)(C1-3alkyl) optionally substituted with halogen or (ii) with C1-3alkyl optionally substituted with halogen, and
wherein any cycloalkyl group, heterocyclic group, phenyl, or heteroaryl ring is optionally substituted by halogen; oxo; CN; OH; C1-6alkoxy; —NR8R9; —C(O)(C1-3alkyl); —(C0-3alkyl)C(O)NR10R11; —S(O)1-2NR8R9; —OP(O)(OC1-3alkyl)2; C3-10cycloalkyl group optionally substituted with OH or halogen; a 3-11 membered saturated or partially saturated heterocyclic group optionally substituted with oxo or C1-3alkyl; a 5-6 membered monocyclic heteroaryl ring optionally substituted by halogen, oxo, CN, OH, C1-3alkyl, or C1-3haloalkyl; or C1-4alkyl optionally substituted by halogen, oxo, CN, OH, O—C1-3 alkyl, —S—C1-3alkyl, —SO2—C1-3alkyl, —NR8R9, —C(O)NR8R9, phenyl, C3-10cycloalkyl, a 3-11 membered saturated or partially saturated heterocyclic group optionally substituted with oxo or C1-3 alkyl, or a 5-6 membered monocyclic heteroaryl ring optionally substituted with oxo, halogen, or C1-3alkyl;
A is a 3-11 membered heterocyclic group optionally substituted by halogen, oxo, CN, OH, C1-6alkyl, —(C0-3alkyl)-C3-6cycloalkyl group, a —(C0-3alkyl)-3-11 membered heterocyclic group, —NR8R9, —NR12C(O)R13—NR12S(O)1-2R13, —C(O)(C1-3alkyl), —C(O)NR10R11, —C(O)OR13, —S(O)1-2NR10R11, or —(C0-3alkyl)-OP(O)(OC1-3alkyl)2,
wherein any alkyl, cycloalkyl group, or heterocyclic group is independently optionally substituted by halogen; oxo; CN; OR13; C1-3haloalkoxy; —C(O)(C1-3alkyl); —S—C1-3alkyl; or C1-3alkyl optionally substituted with OH, halogen, C1-3haloalkyl, C1-3alkoxy, C1-3haloalkoxy, or a 3-8 membered heterocyclic group, and
wherein when A is a 5-membered nitrogen containing heterocyclic group, the nitrogen atom is substituted;
R6 and R7 are, independently at each occurrence, hydrogen, C1-3alkyl, or C3-6cycloalkyl group,
wherein any alkyl or cycloalkyl group is independently optionally substituted by halogen, oxo, CN, OH, C1-3alkyl, C1-3haloalkyl, C1-3alkoxy, or C1-3haloalkoxy;
R8, R9, R10 and R11 are, independently at each occurrence, hydrogen, C1-6alkyl, C3-6cycloalkyl group, —(C0-3alkyl)-phenyl, a 3-11 membered saturated heterocyclic group, a 5-6 membered monocyclic heteroaryl ring, —C(O)R13, —C(O)OR13, —C(O)NR6R7, or —S(O)1-2R13, or R10 and R11 are taken together to form a 5-8 membered heterocyclic group,
wherein any alkyl, cycloalkyl group, phenyl, heterocyclic group, or heteroaryl ring is independently optionally substituted by halogen, oxo, CN, C1-3alkyl, C1-3haloalkyl, C1-3alkoxy, C1-3haloalkoxy, —OR13, —NR6R7, or a 5-6 membered monocyclic heteroaryl ring;
R12 is, independently at each occurrence, hydrogen, C1-6alkyl or C3-6cycloalkyl group,
wherein any alkyl or cycloalkyl group is independently optionally substituted by halogen, oxo, CN, OH, C1-3alkyl, C1-3haloalkyl, C1-3alkoxy, or C1-3haloalkoxy;
R13 is, independently at each occurrence, hydrogen, C1-6alkyl, C3-10cycloalkyl group, or a 3-11 membered saturated heterocyclic group,
wherein any alkyl, cycloalkyl group, or heterocyclic group is independently optionally substituted by halogen, oxo, CN, OH, C1-3alkyl, C1-3haloalkyl, C1-3alkoxy, C1-3haloalkoxy, —OR12, or —NR6R7; and
R16 is hydrogen, halogen, CN, or C1-3alkyl optionally substituted with —NH2, halogen, or CN.

US Pat. No. 10,988,477

GCN2 INHIBITORS AND USES THEREOF

Merck Patent GmbH, Darms...

1. A compound of formula I:
or a pharmaceutically acceptable salt thereof, wherein:
Ring A is a 4-8 membered saturated monocyclic heterocyclic ring having 1-2 heteroatoms independently selected from nitrogen, oxygen, or sulfur;
Ring B is

Ring C is

each of R1 is independently fluoro, methyl, ethyl, —OH, methoxy, —CH2OH,

each of R2 is independently

R3 is hydrogen;
R4 is hydrogen;
m is 0, 1, 2, 3, 4 or 5;
n is 0, 1, or 2;
p is 0 or 1; and
q is 0 or 1.

US Pat. No. 10,988,475

AGONISTS OF THE APELIN RECEPTOR AND METHODS OF USE THEREOF

SANFORD BURNHAM PREBYS ME...

1. A method of treating an apelin-mediated disease or disorder in a subject having said disease or disorder, comprising administering to the subject a therapeutically effective amount of a compound of structural Formula I:
wherein:
A is selected from the group consisting of:

B is selected from the group consisting of:

C is selected from the group consisting of

Y is S; and
X1 and X2 are each N.

US Pat. No. 10,988,474

COMPOUNDS ACTING AT MULTIPLE PROSTAGLANDIN RECEPTORS GIVING A GENERAL ANTI-INFLAMMATORY RESPONSE

ALLERGAN, INC., Irvine, ...

1. A compound represented by the Formula II:or a pharmaceutically acceptable salt thereof, wherein:Y is (CH2)m, wherein m is 0;
Z is O;
W is

R1 is selected from the group consisting of OH and NH2;
R3 is H; and
R4 is Cl.

US Pat. No. 10,988,472

COMPOUNDS AND METHOD FOR BLOCKING TRANSMISSION OF MALARIAL PARASITE

The United States of Amer...

1. A compound of formula (I):
wherein A is CH,
B is CR3?CR4,
R1 is selected from 4-methylsulfonylphenyl, 4-ethylsulfonylphenyl, 2-methyl-4-methylsulfonylphenyl, and 3-piperazinylmethyl-4-methylsulfonylphenyl,
R2 is selected from 4-chlorophenyl, 4-fluorophenyl, 3-cyano-4-chlorophenyl, 3-hydroxy-4-chlorophenyl, 3-amino-4-chlorophenyl, 4-aminomethylphenyl, and 3-methoxy-4-chlorophenyl,
R3 and R4 are independently selected from hydrogen, hydroxyl, OR5, halogen, optionally substituted C6-10 aryl, and optionally substituted C1-6 alkyl, and
R5 is C1-12 alkyl, C6-10 aryl, halogen, or hydroxyl,
or a pharmaceutically acceptable salt thereof.

US Pat. No. 10,988,471

PHARMACEUTICAL COMPOSITION COMPRISING BERBERINE URSODEOXYCHOLIC ACID SALT FOR THE TREATMENT OF VARIOUS DISEASES OR DISORDERS

Shenzhen HighTide Biophar...

1. A method for treating a disease or disorder in a mammal, comprising administering to a mammal in need thereof a therapeutically effective amount of a pharmaceutical composition comprising a pharmaceutically acceptable excipient, carrier, or diluent and a compound having formula (II):
wherein the disease or disorder is selected from the group consisting of atherosclerosis, cancer, inflammation, muscle atrophy, sarcopenia, a heart disease, a liver disease, a metabolic disorder, and a neurodegenerative disease.

US Pat. No. 10,988,469

METHOD FOR PRODUCING OPTICALLY ACTIVE COMPOUND

DOT THERAPEUTICS-1, INC.,...

2. A method of producing an optically active form of a compound represented by the following formula (V):
wherein
R1 is a C1-6 alkyl group;
R2 is a hydrogen atom or a halogen atom;
R3 is a hydrogen atom or an optionally halogenated C1-6 alkyl group;
R4 and R5 are each independently a hydrogen atom, a halogen atom, a cyano group, a nitro group, an optionally substituted hydrocarbon group, an optionally substituted heterocyclic group, an acyl group, an optionally substituted amino group, an optionally substituted carbamoyl group, an optionally substituted thiocarbamoyl group, an optionally substituted sulfamoyl group, a hydroxy group, a sulfanyl (SH) group, or a silyl group; and
the carbon atom marked with * is an asymmetric carbon atom, or a salt thereof,
wherein the method comprises a step of subjecting a compound represented by the following formula (I);
whereinPG is a protecting group that is represented by the following formula (VI) or (VI-1):

wherein
Ar1 is a hydrogen atom or a C6-14 aryl group optionally substituted by C1-6 alkoxy;
Ar2 is a C6-14 aryl group optionally substituted by C1-6 alkoxy; and
R7 is a C6-14 aryl group optionally substituted by C1-6 alkoxy or a C1-6 alkoxy group,
and the other symbols are as defined above, or a salt thereof, to an asymmetric reduction reaction to obtain an optically active form of a compound represented by the following formula (II);

wherein each symbol is as defined above, or a salt thereof,
wherein the asymmetric reduction reaction is a reduction reaction in the presence of a transition metal complex and a reducing agent,
wherein the method further comprises a step of subjecting the optically active form of the compound represented by formula (II) to a deprotection reaction, and a step of reacting the obtained optically active form of a compound represented by the following formula (III);

wherein each symbol is as defined above, or a salt thereof, with a compound represented by the following formula (IV);

wherein
X is a leaving group; and
R4 and R5 are each independently a hydrogen atom, a halogen atom, a cyano group, a nitro group, an optionally substituted hydrocarbon group, an optionally substituted heterocyclic group, an acyl group, an optionally substituted amino group, an optionally substituted carbamoyl group, an optionally substituted thiocarbamoyl group, an optionally substituted sulfamoyl group, a hydroxy group, a sulfanyl (SH) group, or a silyl group, or a salt thereof.

US Pat. No. 10,988,468

NITROGEN-CONTAINING 6-MEMBERED CYCLIC COMPOUND

ASAHI KASEI PHARMA CORPOR...

1. The compound mentioned below, or a salt thereof;

US Pat. No. 10,988,467

COMPOUNDS AS ROR GAMMA MODULATORS

Glenmark Pharmaceuticals ...

1. A process for preparing a compound of formula (Ib)or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof, the process comprising:(i) reacting a compound of formula (1) with a compound of formula (3) to afford a compound of formula (4); and

(ii) reducing the ketone group in the compound of formula (4) to afford the compound of formula (Ib), or a stereoisomer thereof, or a pharmaceutically acceptable salt thereof,
whereinring A is selected from

ring B is selected from C3-6cycloalkyl, C6-14aryl, 3-15 membered heterocyclyl and 5 to 14 membered heteroaryl;
L is absent or is y*—CR—(CRxRy)t—*z;
X is selected from O, NRx1 and

each of x, y and z represents a point of attachment;
each occurrence of R2 is independently selected from cyano, halogen, hydroxyl, C1-8alkyl, C1-8alkoxy, C1-8alkoxyC1-8alkyl, haloC1-8alkyl, haloC1-8alkoxy, hydroxyC1-8alkyl, C(O)C1-8alkyl, C3-6cycloalkyl, C(O)C3-6cycloalkyl and 3 to 15 membered heterocyclic ring;
each occurrence of R3 is independently selected from halogen, cyano, C1-8alkyl, haloC1-8alkyl and C3-6cycloalkyl;
each occurrence of R4 is independently selected from halogen, cyano, C1-8alkyl, haloC1-8alkyl and C3-6cycloalkyl;
each occurrence of R5 is independently selected from halogen, cyano, C1-8alkyl, haloC1-8alkyl and C3-6cycloalkyl;
Rb is C1-8alkyl;
Rx and Ry, which may be same or different, are each independently selected from hydrogen, C1-8alkyl and hydroxyC1-8alkyl, or Rx and Ry together with the carbon atom to which they are attached, form a 3 to 6 membered cycloalkyl ring;
Rx1 is selected from hydrogen or C1-8alkyl;
‘n’ is 0, 1, 2 or 3;
‘m’ is 0, 1 or 2;
‘p’ is 0, 1 or 2;
‘q’ is 0, 1, 2 or 3; and
‘t’ is 0, 1, 2 or 3.

US Pat. No. 10,988,466

HETEROCYCLIC DERIVATIVES USEFUL AS SHP2 INHIBITORS

Jacobio Pharmaceuticals C...

1. A compound which is:
or a pharmaceutically acceptable salt thereof.

US Pat. No. 10,988,465

CXCR4 INHIBITORS AND USES THEREOF

X4 PHARMACEUTICALS, INC.,...

1. A compound of Formula I:or a pharmaceutically acceptable salt thereof, wherein:Ring A is a 3-8 membered saturated or partially unsaturated monocyclic carbocyclic ring, phenyl, an 8-10 membered bicyclic aromatic carbocyclic ring, a 4-8 membered saturated or partially unsaturated monocyclic heterocyclic ring having 1-2 heteroatoms independently selected from nitrogen, oxygen, or sulfur, a 5-6 membered monocyclic heteroaromatic ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur, or an 8-10 membered bicyclic heteroaromatic ring having 1-5 heteroatoms independently selected from nitrogen, oxygen, or sulfur; provided that Ring A is not
each R1 is independently R, halogen, —CN, —OR, —N(R)2, —NO2, —N3, —SR, or -L1-R6;each R is independently hydrogen or an optionally substituted group selected from C1-6 aliphatic, a 3-8 membered saturated or partially unsaturated monocyclic carbocyclic ring, phenyl, an 8-10 membered bicyclic aromatic carbocyclic ring, a 4-8 membered saturated or partially unsaturated monocyclic heterocyclic ring having 1-2 heteroatoms independently selected from nitrogen, oxygen, or sulfur, a 5-6 membered monocyclic heteroaromatic ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur, or an 8-10 membered bicyclic heteroaromatic ring having 1-5 heteroatoms independently selected from nitrogen, oxygen, or sulfur;
each L1 and L2 is independently a covalent bond or a C1-8 bivalent straight or branched hydrocarbon chain wherein 1, 2, or 3 methylene units of the chain are independently and optionally replaced with —O—, —C(O)—, —C(O)O—, —OC(O)—, —N(R)—, —C(O)N(R)—, —(R)NC(O)—, —OC(O)N(R)—, —(R)NC(O)O—, —N(R)C(O)N(R)—, —S—, —SO—, —SO2—, —SO2N(R)—, —(R)NSO2—, —C(S)—, —C(S)O—, —OC(S)—, —C(S)N(R)—, —(R)NC(S)—, —(R)NC(S)N(R)—, or -Cy-;
each -Cy- is independently a bivalent optionally substituted 3-8 membered saturated or partially unsaturated monocyclic carbocyclic ring, optionally substituted phenylene, an optionally substituted 4-8 membered saturated or partially unsaturated monocyclic heterocyclic ring having 1-3 heteroatoms independently selected from nitrogen, oxygen, or sulfur, an optionally substituted 5-6 membered monocyclic heteroaromatic ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur, an optionally substituted 8-10 membered bicyclic or bridged bicyclic saturated or partially unsaturated heterocyclic ring having 1-5 heteroatoms independently selected from nitrogen, oxygen, or sulfur, or an optionally substituted 8-10 membered bicyclic or bridged bicyclic heteroaromatic ring having 1-5 heteroatoms independently selected from nitrogen, oxygen, or sulfur;
R2 is hydrogen, -L2-R6, or optionally substituted C1-8 aliphatic;
R3 is hydrogen, optionally substituted C1-6 aliphatic, or -L3-R6;
L3 is a C1-6 bivalent straight or branched hydrocarbon chain wherein 1, 2, or 3 methylene units of the chain are independently and optionally replaced with —O—, —C(O)—, —C(O)O—, —OC(O)—, —N(R)—, —C(O)N(R)—, —(R)NC(O)—, —S—, —SO—, —SO2—, —C(S)—, or -Cy-;
each R4 is independently hydrogen, deuterium, halogen, —CN, —OR6, or C1-4 alkyl, or two R4 groups on the same carbon are optionally taken together to form ?NR6, ?NOR6, ?O, or ?S;
each R5 is independently R, halogen, —CN, —OR, —N(R)2, —NO2, —N3, —SR, or -L1-R6, or two R5 groups on the same saturated carbon atom are optionally taken together to form ?NR, ?NOR, ?O, ?S, or a spirocyclic 3-6 membered carbocyclic ring;
each R6 is independently hydrogen or C1-6 alkyl optionally substituted with 1, 2, 3, 4, 5, or 6 deuterium or halogen atoms;
m is 0, 1, 2, 3, or 4;
n is 0, 1, 2, 3, or 4; and
p is 0, 1, 2, 3, or 4.

US Pat. No. 10,988,462

PYRAZOLE COMPOUNDS SUBSTITUTED WITH HETEROARYL AND PHARMACEUTICAL USE THEREOF

Japan Tobacco Inc., Toky...

1. A compound of Formula [X]:
wherein R1 is hydrogen or halogen;
R2 is C1-6 alkyl or halo-C1-6 alkyl;
Ring Het is:
(1) pyridyl substituted with R3; or
(2) pyrazinyl, pyrimidinyl, or pyridazinyl, optionally substituted with R4;
R3 is cyano, halogen, or halo-C1-3 alkyl;
R4 is halogen, hydroxy, C1-3 alkyl, halo-C1-3 alkyl, C1-3 alkoxy, or —N(R5)(R6); and
R5 and R6 are each independently hydrogen or C1-3 alkyl,
or a pharmaceutically acceptable salt thereof.

US Pat. No. 10,988,461

SMALL MOLECULE IRE1-? INHIBITORS

Cornell University, Itha...

1. A compound of formula I,
wherein:
A is a heteroaromatic ring, where the A ring has x R1 substituents;
B is pyrazolyl, imidazolyl, or triazolyl;
C is phenyl or pyridinyl;
D is a six- or seven-membered saturated heterocyclyl ring;
linkage1 is a single bond between A and B;
linkage2 is a urea, alkylurea, or ureaalkyl with a first and second terminal atom;
y is an integer of 1-3;
x is an integer of 0-4;
v is an integer of 0-2;
R1 substituents on the A ring are selected from amino, optionally substituted C1-C4 alkyl, optionally substituted ether, optionally substituted C1-C4 alkoxy, hydroxy, —NH—SO2-phenyl-(R5), and cyano;
R2 substituents on the B ring are selected from amino, and optionally substituted C1-C4 alkyl;
R3 substituents on the C ring are selected from halo, CF3, optionally substituted C1-C4 alkyl, and optionally substituted heteroaryl; and
R4 substituents on the D ring are selected from optionally substituted C1-C4 alkyl, optionally substituted C1-C4 alkoxy, (optionally substituted C1-C4 alkylene)-OH, hydroxy, optionally substituted aryl, optionally substituted benzyl, and optionally substituted benzaldehyde; and
R5 is halo; or
a pharmaceutically acceptable salt thereof.

US Pat. No. 10,988,460

SUBSTITUTED PYRAZOLE-PYRIMIDINES, VARIANTS THEREOF, AND USES THEREFORE

Afferent Pharmaceuticals,...

1. A compound of Formula I:or a pharmaceutically acceptable salt thereof, wherein:ring
is selected from the group consisting of:
W is CH2, NH, N—C1-6 alkylene, O or S;
X6 is CR3; wherein R3 is hydrogen or C1-12alkyl;
Y is hydrogen or —NHRd; wherein Rd is selected from the group consisting of hydrogen, C1-12alkyl, C3-12cycloalkyl, aryl, and heteroaryl; wherein each of the C1-12alkyl, C3-12cycloalkyl, aryl, and heteroaryl is optionally substituted with one to three substituents independently selected from halogen, hydroxyl and C1-6alkyl;
D is an optional oxygen;
each occurrence of R1 is independently selected from the group consisting of hydrogen, hydroxyl, C1-6alkyl, C2-6alkenyl, and C2-6alkynyl; wherein each of the C1-6alkyl, C2-6alkenyl, and C2-6alkynyl is optionally substituted with one to three substituents independently selected from halogen and hydroxyl;
each occurrence of R2 is independently selected from the group consisting of hydrogen, halogen, —NH—Rf, —C(O)—NHRf, C2-12alkenyl, C2-12alkynyl, and —O—C1-12alkyl;
each occurrence of Rf is independently selected from the group consisting of hydrogen, C1-12alkYl, hydroxyl, —SO2—NH2, and —SO2—C1-6alkyl; and
R7 is selected from the group consisting of hydrogen, C1-12alkyl, and C3-12cycloalkyl.

US Pat. No. 10,988,458

APOPTOSIS SIGNAL-REGULATING KINASE 1 INHIBITORS AND METHODS OF USE THEREOF

Enanta Pharmaceuticals, I...

1. A compound represented by Formula (I) or a pharmaceutically acceptable salt or ester thereof:
wherein;
is selected from
X1, X2 and X3 are each independently selected from N or C(R5);
R3, R4 and R5 are each independently selected from the group consisting of:
1) Hydrogen;
2) Halogen;
3) —NO2;
4) Cyano;
5) Optionally substituted —C1-C8 alkyl;
6) Optionally substituted —C3-C8 cycloalkyl;
7) Optionally substituted 3- to 8-membered heterocycloalkyl; and
8) Optionally substituted —C1-C8 alkoxyl;
R is selected from the group consisting of

R1 is

R2 is selected from the group consisting of:
1) Hydrogen;
2) Halogen;
3) —NO2;
4) Cyano;
5) Optionally substituted —C1-C8 alkyl;
6) Optionally substituted —C2-C8 alkenyl;
7) Optionally substituted —C2-C8 alkynyl;
8) Optionally substituted —C3-C8 cycloalkyl;
9) Optionally substituted aryl;
10) Optionally substituted arylalkyl;
11) Optionally substituted 3- to 8-membered heterocycloalkyl;
12) Optionally substituted heteroaryl;
13) Optionally substituted heteroarylalkyl;
14) —N(R6)(R7);
15) —S(O)2N(R6)(R7);
16) —N(R6)C(O)(R7); and
17) —N(R6)S(O)2(R7);
wherein R6 and R7 are independently selected from the group consisting of hydrogen, —C1-C15 alkyl; cycloalkyl, heterocycloalkyl, aryl, and heteroaryl, wherein each alkyl, cycloalkyl, heterocycloalkyl, aryl and heteroaryl is optionally substituted with 1-3 substituents independently selected from halo, alkyl, alkylamino, dialkylamino, alkylC(O)NH—, arylC(O)NH—, heteroarylC(O)NH—, —CN, alkoxy, —CF3, aryl, and heteroaryl, alternatively, R7 and R6 are taken together with the nitrogen atom to which they are attached to form a heterocyclic.

US Pat. No. 10,988,451

MCL-1 INHIBITORS

Gilead Sciences, Inc., F...

1. A compound according to Formula (I):wherein: is a single or double bond;
X is O or NR7;
R12 is hydrogen or —C(O)R1;
R1 is C1-6alkyl, C1-6haloalkyl, C2-6alkenyl, C2-6alkynyl, C3-10cycloalkyl, C6-10aryl, 3-12 membered heterocyclyl, 5-10 membered heteroaryl, —OR7, or —NR8R9, wherein
said C1-6alkyl, C2-6alkynyl, C3-10cycloalkyl, C6-10aryl, 3-12 membered heterocyclyl, and 5-10 membered heteroaryl are optionally substituted with 1-5 R10 groups;
R2 is hydrogen, C1-6alkyl, C1-6heteroalkyl, C3-10cycloalkyl, or 3-12 membered heterocyclyl, wherein
said C1-6alkyl, C1-6heteroalkyl, C3-10cycloalkyl, and 3-12 membered heterocyclyl are optionally substituted with 1-5 R10 groups;
R3 and R4 are independently hydrogen, C1-6alkyl, —OR7, C1-6heteroalkyl, —NR8R9, NR8C(O)R9, —NRC(O)OR9, C6-10aryl, C3-10cycloalkyl, 5-10 membered heteroaryl, 3-12 membered heterocyclyl, —C(O)R7, —C(O)OR7, —C(O)NR8R9, —OC(O)NR8R9, —CN, or —SO2R7, wherein
said C1-6alkyl, C1-6heteroalkyl, C6-10aryl, C3-10cycloalkyl, 5-10 membered heteroaryl, and 3-12 membered heterocyclyl are optionally substituted with 1-5 R10 groups;
R5 is hydrogen, C1-6alkyl, —(CH2CH2O)pR7, C1-6heteroalkyl, C6-10aryl, C3-10cycloalkyl, 5-10 membered heteroaryl, or 3-12 membered heterocyclyl, wherein
said C1-6alkyl, C1-6heteroalkyl, C6-10aryl, C3-10cycloalkyl, 5-10 membered heteroaryl, and 3-12 membered heterocyclyl are optionally substituted with 1-5 R10 groups;
R6 is hydrogen or halo;
each R7 is independently hydrogen, C1-6alkyl, C3-10cycloalkyl, C1-6heteroalkyl, 3-12 membered heterocyclyl, C6-10aryl, or 5-10 membered heteroaryl, wherein
said C1-6alkyl, C3-10cycloalkyl, C1-6heteroalkyl, 3-12 membered heterocyclyl, C6-10 aryl, and 5-10 membered heteroaryl are optionally substituted with from 1-5 R10;
each R8 and R9 are independently hydrogen, C1-6alkyl, C3-10cycloalkyl, C1-6heteroalkyl, 3-12 membered heterocyclyl, C6-10aryl, or 5-10 membered heteroaryl, or R8 and R9 together with the atoms to which they are attached form a 3-12 membered heterocycle, wherein
said C1-6alkyl, C3-10cycloalkyl, C1-6heteroalkyl, 3-12 membered heterocyclyl, C6-10aryl, and 5-10 membered heteroaryl are optionally substituted with 1-5 R10;
each R10 is independently C1-6alkyl, C3-10cycloalkyl, C1-6heteroalkyl, 3-12 membered heterocyclyl, C6-10aryl, 5-10 membered heteroaryl, halo, oxo, —ORa, —C(O)Ra, —C(O)ORa, —C(O)NRaRb, —OC(O)NRaRb, —NRaRb, —NRaC(O)Rb, —NRaC(O)ORb, —S(O)qRa, —S(O)2NRaRb, —NRaS(O)2Rb, —N3, —CN, or —NO2, or two R10 groups form a fused, spiro, or bridged C3-10 cylcloalkyl or 3-12 membered heterocyclyl, wherein
each C1-6alkyl, C1-6 heteroalkyl, C2-6alkynyl, C3-10cycloalkyl, C6-10aryl, 3-12 membered heterocycle, and 5-10 membered heteroaryl is optionally substituted with 1-5 R20 groups;
each Ra and Rb is independently hydrogen, C1-6alkyl, C2-6 alkenyl, C3-10cycloalkyl, C1-6heteroalkyl, 3-12 membered heterocyclyl, C6-10aryl, 5-10 membered heteroaryl, or Ra and Rb together with the atoms to which they are attached form a 3-12 membered heterocyclyl wherein
said C1-6alkyl, C2-6 alkenyl, C3-10cycloalkyl, C1-6heteroalkyl, 3-12 membered heterocyclyl, C6-10aryl, 5-10 membered heteroaryl is optionally substituted with 1-5 R20 groups;
each R20 is independently C1-6 alkyl, C3-10 cycloalkyl, C1-6 heteroalkyl, 3-12 membered heterocyclyl, C6-C10 aryl, 5-10 membered heteroaryl, hydroxyl, C1-6 alkoxy, amino, —CN, —C(O)H, —C(O)NH2, —C(O)NH(C1-6 alkyl), —C(O)N(C1-6 alkyl)2, —COOH, —C(O)C1-6 alkyl, —C(O)OC1-6 alkyl, or halogen;
n is 0, 1, or 2;
p is 0, 1, or 2;
q is 0, 1, or 2;
the C1-6heteroalkyl is an alkyl group in which one to three of the carbon atoms are each independently replaced with the same or different heteroatomic group; wherein C1-6heteroalkyl has 1-6 carbon atoms; and wherein the heteroatomic group is independently selected from nitrogen, sulfur, phosphorus, oxygen, —N(O)—, —S(O)—, and —S(O)2—;
the 3-12 membered heterocyclyl is a non-aromatic group having a single ring or multiple rings; wherein the 3-12 membered heterocyclyl has one to three heteroatoms independently selected from nitrogen, sulfur, phosphorus, —N(O)—, —S(O)—, and —S(O)2—; wherein the multiple rings may be fused, bridged, or spiro; and
the 5-10 membered heteroaryl is an aromatic group having a single ring or multiple rings; wherein the 5-10 membered heteroaryl contains one to three ring heteroatoms independently selected from nitrogen, oxygen, sulfur, —N(O)—, —S(O)—, and —S(O)2;or a pharmaceutically acceptable salt thereof.

US Pat. No. 10,988,450

3-ALKYL-4-AMIDO-BICYCLIC [4,5,0] HYDROXAMIC ACIDS AS HDAC INHIBITORS

Valo Early Discovery, Inc...

1. A compound of Formula I:
or a pharmaceutically acceptable salt thereof, wherein:
X1 is O;
X2 and X4 are each CR1R2;
X3 is CR1?R2?;
Y1 and Y4 are not bound to —C(O)NHOH and are each CR1;
Y2 and Y3 are CR1 when not bonded to —C(O)NHOH and Y2 and Y3 are C when bonded to —C(O)NHOH;
L is selected from the group consisting of —C(O)—, —C(O)(CR1R2)m—, and —C(O)(CR1R2)mO—, wherein L is bound to the ring nitrogen through the carbonyl group;
R is independently selected from the group consisting of —H, —C1-C6 alkyl, —C2-C6 alkenyl, —C4-C8 cycloalkenyl, —C2-C6 alkynyl, —C3-C8 cycloalkyl, —C5-C12 spirocyclyl, heterocyclyl, spiroheterocyclyl, aryl, and heteroaryl containing 1-5 heteroatoms selected from the group consisting of N, S, P, and O, wherein each alkyl, alkenyl, cycloalkenyl, alkynyl, cycloalkyl, spirocyclyl, heterocyclyl, spiroheterocyclyl, aryl, or heteroaryl is optionally substituted with one or more substituents selected from the group consisting of —OH, halogen, oxo, —NO2, —CN, —R1, —R2, —OR3, —NHR3, —NR3R4, —S(O)2NR3R4, —S(O)2R1, —C(O)R1, —CO2R1, —NR3S(O)2R1, —S(O)R1, —S(O)NR3R4, —NR3S(O)R1, heterocyclyl, aryl, and heteroaryl containing 1-5 heteroatoms selected from the group consisting of N, S, P, and O, with the proviso that R is not bound to L via a nitrogen atom;
R1 and R2 are independently, at each occurrence, selected from the group consisting of —H, —R3, —R4, —C1-C6 alkyl, —C2-C6 alkenyl, —C3-C8 cycloalkenyl, —C2-C6 alkynyl, —C3-C8 cycloalkyl, heterocyclyl, aryl, heteroaryl containing 1-5 heteroatoms selected from the group consisting of N, S, P, and O, —OH, halogen, —NO2, —CN, —NHC1-C6 alkyl, —N(C1-C6 alkyl)2, —S(O)2N(C1-C6 alkyl)2, —N(C1-C6 alkyl)S(O)2R5, —S(O)2(C1-C6 alkyl), —(C1-C6 alkyl)S(O)2R5, —C(O)C1-C6 alkyl, —CO2C1-C6 alkyl, —N(C1-C6 alkyl)S(O)2C1-C6 alkyl, and —(CHR5)nNR3R4, wherein each alkyl, alkenyl, cycloalkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl is optionally substituted with one or more substituents selected from the group consisting of —OH, halogen, —NO2, oxo, —CN, —R5, —OR3, —NHR3, —NR3R4, —S(O)2N(R3)2, —S(O)2R5, —C(O)R5, —CO2R5, —NR3S(O)2R5, —S(O)R5, —S(O)NR3R4, —NR3S(O)R5, heterocyclyl, aryl, and heteroaryl containing 1-5 heteroatoms selected from the group consisting of N, S, P, and O;
and one of R1 and R2 of X2 combines with one of R1 and R2 of X4 to form a bridging ring;
R1? and R2? are independently, at each occurrence, selected from the group consisting of —H, —C1-C6 alkyl, —C2-C6 alkenyl, —C3-C8 cycloalkenyl, —C2-C6 alkynyl, —C3-C8 cycloalkyl, heterocyclyl, —OH, halogen, —NO2, —CN, —NHC1-C6 alkyl, —N(C1-C6 alkyl)2, —S(O)2N(C1-C6 alkyl)2, —N(C1-C6 alkyl)S(O)2R5, —S(O)2(C1-C6 alkyl), —(C1-C6 alkyl)S(O)2R5, —C(O)C1-C6 alkyl, —CO2C1-C6 alkyl, —N(C1-C6 alkyl)S(O)2C1-C6 alkyl, and —(CHR5)nNR3R4, wherein each alkyl, alkenyl, cycloalkenyl, alkynyl, cycloalkyl, or heterocyclyl is optionally substituted with one or more substituents selected from the group consisting of —OH, halogen, —NO2, oxo, —CN, —R5, —OR3, —NHR3, —NR3R4, —S(O)2N(R3)2, —S(O)2R5, —C(O)R5, —CO2R5, —NR3S(O)2R5, —S(O)R5, —S(O)NR3R4, —NR3S(O)R5, heterocyclyl, aryl, and heteroaryl containing 1-5 heteroatoms selected from the group consisting of N, S, P, and O;
R3 and R4 are independently, at each occurrence, selected from the group consisting of —H, —C1-C6 alkyl, —C2-C6 alkenyl, —C3-C8 cycloalkenyl, —C2-C6 alkynyl, —C3-C8 cycloalkyl, heterocyclyl, aryl, heteroaryl containing 1-5 heteroatoms selected from the group consisting of N, S, P, and O, —S(O)2N(C1-C6 alkyl)2, —S(O)2(C1-C6 alkyl), —(C1-C6 alkyl)S(O)2R5, —C(O)C1-C6 alkyl, —CO2C1-C6 alkyl, and —(CHR5)nN(C1-C6 alkyl)2, wherein each alkyl, alkenyl, cycloalkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, and heteroaryl is optionally substituted with one or more substituents selected from the group consisting of —OH, halogen, —NO2, oxo, —CN, —R5, —O(C1-C6 alkyl), —NH(C1-C6 alkyl), —N(C1-C6 alkyl)2, —S(O)2N(C1-C6 alkyl)2, —S(O)2NHC1-C6 alkyl, —C(O)C1-C6 alkyl, —CO2C1-C6 alkyl, —N(C1-C6 alkyl)S(O)2C1-C6 alkyl, —S(O)R5, —S(O)N(C1-C6 alkyl)2, —N(C1-C6 alkyl)S(O)R5, heterocyclyl, aryl, and heteroaryl containing 1-5 heteroatoms selected from the group consisting of N, S, P, and O;
R5 is independently, at each occurrence, selected from the group consisting of —H, —C1-C6 alkyl, —C2-C6 alkenyl, —C3-C8 cycloalkenyl, —C2-C6 alkynyl, —C3-C8 cycloalkyl, heterocyclyl, aryl, heteroaryl containing 1-5 heteroatoms selected from the group consisting of N, S, P, and O, —OH, halogen, —NO2, —CN, —NH(C1-C6 alkyl), —N(C1-C6 alkyl)2, —S(O)2NH(C1-C6 alkyl), —S(O)2N(C1-C6 alkyl)2, —S(O)2C1-C6 alkyl, —C(O)C1-C6 alkyl, —CO2C1-C6 alkyl, —N(C1-C6 alkyl)SO2C1-C6 alkyl, —S(O)(C1-C6 alkyl), —S(O)N(C1-C6 alkyl)2, —N(C1-C6 alkyl)S(O)(C1-C6 alkyl), and —(CH2)nN(C1-C6 alkyl)2;
each n is independently and at each occurrence an integer from 0 to 6; and
each m is independently and at each occurrence an integer from 1 to 6.

US Pat. No. 10,988,447

BIPYRIDINE DERIVATIVES AND THEIR USES FOR ORGANIC LIGHT EMITTING DIODES

SAMSUNG ELECTRONICS CO., ...

1. A condensed cyclic compound represented by Formula 1:Ar1-(L1)a1-B-(L2)a2-Ar2  Formula 1
wherein, in Formula 1,
B is a group represented by Formula 2:

wherein, in Formula 2,
X1 is N, X2 is CH, and X3 is CH;
X1 is CH, X2 is N, and X3 is CH; or
X1 is CH, X2 is CH, and X3 is N;
L1 and L2 are each independently selected from a substituted or unsubstituted C6-C60 aryl group, a substituted or unsubstituted C6-C60 aryloxy group, a substituted or unsubstituted C6-C60 arylthio group, a substituted or unsubstituted C7-C60 arylalkyl group, a substituted or unsubstituted C1-C60 heteroaryl group, a substituted or unsubstituted C2-C60 heteroaryloxy group, a substituted or unsubstituted C2-C60 heteroarylthio group, a substituted or unsubstituted C3-C60 heteroarylalkyl group,
wherein at least one of substituents of the substituted C6-C60 aryl group, substituted C6-C60 aryloxy group, substituted C6-C60 arylthio group, substituted C7-C60 arylalkyl group, substituted C1-C60 heteroaryl group, substituted C2-C60 heteroaryloxy group, substituted C2-C60 heteroarylthio group, and substituted C3-C60 heteroarylalkyl group is selected from a deuterium, —F, —Cl, —Br, —I, a hydroxyl group, a cyano group, a nitro group, an amino group, an amidino group, a hydrazine group, a hydrazone group, a carboxylic acid group or a salt thereof, a sulfonic acid group or a salt thereof, a phosphoric acid group or a salt thereof, a C1-C60 alkyl group, a C2-C60 alkenyl group, a C2-C60 alkynyl group, a C1-C60 alkoxy group, a C3-C60 cycloalkyl group, a C1-C60 heterocycloalkyl group, a C3-C60 cycloalkenyl group, a C1-C60 heterocycloalkenyl group, a C6-C60 aryl group, a C6-C60 aryloxy group, a C6-C60 arylthio group, a C7-C60 arylalkyl group, a C1-C60 heteroaryl group, a C2-C60 heteroaryloxy group, a C2-C60 heteroarylthio group, a C3-C60 heteroarylalkyl group, and —Si(Q1)(Q2)(Q3), wherein Q1 to Q3 are each independently selected from a hydrogen, a C1-C60 alkyl group, a C1-C60 alkoxy group, a C3-C60 cycloalkyl group, a C1-C60 heterocycloalkyl group, a C3-C60 cycloalkenyl group, a C1-C60 heterocycloalkenyl group, a C6-C60 aryl group, and a C1-C60 heteroaryl group;
* represents a point of connection to Ar1 when a1 is 0;
* represents a point of connection to L1 when a1 is 1 to 5;
*? represents a point of connection to Ar2 when a2 is 0;
*? represents a point of connection to L2 when a2 is 1 to 5;
a1 and a2 are each independently an integer selected from 0 to 5, provided that
when a1 is 2 or greater, two or more groups L1 are identical to or different from each other, and
when a2 is 2 or greater, two or more groups L2 are identical to or different from each other;
Ar1 and Ar2 are each independently a group represented by one of Formulae 3A to 3F

wherein, in Formulae 3A to 3F, X4 is O, S, Se, N(R3), P(?O)(R4), C(R5)(R6), or Si(R7)(R8),
provided that i) when X4 is N(R3) then the sum of a1 and a2 is at least one, and ii) when X4 is N(R3) and the sum of a1 and a2 is one, then L1 and L2 are not pyridinylene;
wherein, in Formulae 3A to 3F,
CY is a substituted or unsubstituted C6-C60 aryl ring or a substituted or unsubstituted C1-C60 heteroaryl ring,
n1 is 0, 1, 2, or 4,
n2 is 0 or 1,
R1, R2, and R5 to R8 are each independently selected from a hydrogen, a deuterium, —F, —Cl, —Br, —I, a hydroxyl group, a cyano group, a nitro group, an amino group, an amidino group, a hydrazine group, a hydrazone group, a carboxylic acid group or a salt thereof, a sulfonic acid group or a salt thereof, a phosphoric acid group or a salt thereof, a substituted or unsubstituted C1-C60 alkyl group, a substituted or unsubstituted C2-C60 alkenyl group, a substituted or unsubstituted C2-C60 alkynyl group, a substituted or unsubstituted C1-C60 alkoxy group, a substituted or unsubstituted C3-C60 cycloalkyl group, a substituted or unsubstituted C1-C60 heterocycloalkyl group, a substituted or unsubstituted C3-C60 cycloalkenyl group, a substituted or unsubstituted C1-C60 heterocycloalkenyl group, a substituted or unsubstituted C6-C60 aryl group, a substituted or unsubstituted C6-C60 aryloxy group, a substituted or unsubstituted C6-C60 arylthio group, a substituted or unsubstituted C7-C60 arylalkyl group, a substituted or unsubstituted C1-C60 heteroaryl group, a substituted or unsubstituted C2-C60 heteroaryloxy group, a substituted or unsubstituted C2-C60 heteroarylthio group, a substituted or unsubstituted C3-C60 heteroarylalkyl group, and —Si(Q4)(Q5)(Q6), wherein Q4 to Q6 are each independently selected from a hydrogen, a C1-C60 alkyl group, a C1-C60 alkoxy group, a C3-C60 cycloalkyl group, a C1-C60 heterocycloalkyl group, a C3-C60 cycloalkenyl group, a C1-C60 heterocycloalkenyl group, a C6-C60 aryl group, and a C1-C60 heteroaryl group,
R3 and R4 is a substituted or unsubstituted C6-C60 aryl group or a substituted or unsubstituted C1-C60 heteroaryl group,
wherein at least one of substituents of the substituted C1-C60 alkyl group, substituted C2-C60 alkenyl group, substituted C2-C60 alkynyl group, substituted C1-C60 alkoxy group, substituted C3-C10 cycloalkyl group, substituted C1-C60 heterocycloalkyl group, substituted C3-C60 cycloalkenyl group, substituted C1-C60 heterocycloalkenyl group, substituted C6-C60 aryl group, substituted C6-C60 aryloxy group, substituted C6-C60 arylthio group, substituted C7-C60 arylalkyl group, substituted C1-C60 heteroaryl group, substituted C2-C60 heteroaryloxy group, substituted C2-C60 heteroarylthio group, and substituted C3-C60 heteroarylalkyl group is selected from a deuterium, —F, —Cl, —Br, —I, a hydroxyl group, a cyano group, a nitro group, an amino group, an amidino group, a hydrazine group, a hydrazone group, a carboxylic acid group or a salt thereof, a sulfonic acid group or a salt thereof, a phosphoric acid group or a salt thereof, a C1-C60 alkyl group, a C2-C60 alkenyl group, a C2-C60 alkynyl group, a C1-C60 alkoxy group, a C3-C60 cycloalkyl group, a C1-C60 heterocycloalkyl group, a C3-C60 cycloalkenyl group, a C1-C60 heterocycloalkenyl group, a C6-C60 aryl group, a C6-C60 aryloxy group, a C6-C60 arylthio group, a C7-C60 arylalkyl group, a C1-C60 heteroaryl group, a C2-C60 heteroaryloxy group, a C2-C60 heteroarylthio group, a C3-C60 heteroarylalkyl group, and —Si(Q7)(Q8)(Q9), wherein Q7 to Q9 are each independently selected from a hydrogen, a C1-C60 alkyl group, a C1-C60 alkoxy group, a C3-C60 cycloalkyl group, a C1-C60 heterocycloalkyl group, a C3-C60 cycloalkenyl group, a C1-C60 heterocycloalkenyl group, a C6-C60 aryl group, and a C1-C60 heteroaryl group, and
*? represents a point of connection of Ar1 to B when a1 is 0,
*? represents a point of connection of Ar2 to B when a2 is 0,
*? represents a point of connection of Ar1 to L1 when a1 is 1 to 5,
*? represents a point of connection to Ar2 to L2 when a2 is 1 to 5.

US Pat. No. 10,988,444

ANTIMICROBIAL COMPOUNDS

NEWSOUTH INNOVATIONS PTY ...

1. A compound of Formula (I):wherein:J is
wherein Het is substituted or unsubstituted heteroaryl;A is —NH—, —O— or —S—;
L is a saturated or unsaturated hydrocarbyl group having 1 to 12 carbon atoms, or L is —(CH2—CH2—O)r— wherein r is 2, 3 or 4;
E is a hydrophobic group selected from —C(?O)Re or —SO2Re, wherein Re is C6-18alkyl, C6-18alkenyl, C6-18alkynyl, aryl or heteroaryl, and wherein Re may optionally be substituted;
Ra is independently selected from a substituted or unsubstituted amino group, a guanidine (—NH—C(?NH)(NH2)) group, a CH3-substituted guanidine (—[NCH3—C(?NH)(NH2)]) group, a substituted or unsubstituted ammonium group, a guanidinium (—[NH—C(?NH)(NH3)]+) group or a CH3-substituted guanidinium(—[NCH3—C(?NH)(NH3)]+) group;m is 1, 2 or 3;
Rb, when present, is independently selected from: a substituted or unsubstituted amino group, a guanidine (—NH—C(?NH)(NH2)) group, a CH3-substituted guanidine (—[NCH3—C(?NH)(NH2)]) group, a substituted or unsubstituted ammonium group, a guanidinium (—[NH—C(?NH)(NH3)]+) group, a CH3-substituted guanidinium (—[NCH3—C(?NH)(NH3)]+) group, a Rc-substituted or unsubstituted triazolyl group, —CONHRc or —COORc, wherein Rc is H, a straight or branched C1-12alkyl group, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl, or Rc is -L-(Ra)m, wherein L, Ra and m are as defined above and wherein L may optionally be substituted with —CONHRd or —COORd, wherein Rd is a straight or branched C1-12alkyl group;
n is 0, 1, 2 or 3;
R1, when present, is independently selected from Br, Cl, F, —C1-3alkyl, —C1-3alkoxy, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, —SO3H, —SO3Na, —SO2(C1-3alkyl), —SO2(OC1-3alkyl) or —SO2(N(C1-3alkyl)(C1-3alkyl)); and
p is 0, 1, 2, 3 or 4;
or a salt thereof;
wherein when:
J is

A is —NH—;
L is —(CH2—CH2)—;
E is —C(?O)Re and Re is phenyl;
m is 1;
n is 0; and
p is 0,
Ra is not dimethylamino or diethylamino; and
wherein when:
J is

A is —NH—;
L is —(CH2—CH2—CH2)—;
E is —C(?O)Re and Re is phenyl;
m is 1;
n is 0; and
p is 0,
Ra is not dimethylamino.

US Pat. No. 10,988,441

ALPHA-CINNAMIDE COMPOUNDS AND COMPOSITIONS AS HDAC8 INHIBITORS

Valo Early Discovery, Inc...

1. A compound of Formula (I-a):
or a pharmaceutically acceptable salt thereof,
wherein
A is hydrogen;
het is an imidazolidine-2-one, substituted with one or more Rd;
each Rd is independently C1-C6 alkyl, C1-C6 haloalkyl, C3-C8 cycloalkyl, 3-to-12 membered heterocycloalkyl, aryl, heteroaryl, or —(CH2)nRe, wherein each alkyl, haloalkyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl is optionally substituted with one or more Re or Rf;
each Re is independently hydrogen, C1-C6 alkyl, C1-C6 alkoxy, C3—C cycloalkyl, heterocycloalkyl, wherein each alkyl, alkoxy, cycloalkyl, or heterocycloalkyl is optionally substituted with one or more Rf;
each Rf is independently hydrogen, C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 alkoxy, cycloalkyl, 3-to-12 membered heterocycloalkyl, halogen, —(CH2)nO(CH2)mCH3;
n is 0, 1, 2, 3, or 4; and
m is 0, 1, 2, 3, or 4.

US Pat. No. 10,988,439

CYTOTOXIC COMPOUNDS, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS OF TREATING CANCER

King Abdulaziz University...

1. A compound of formula (I),
or a salt thereof, a solvate thereof, a tautomer thereof, a stereoisomer thereof, or a mixture thereof;
wherein:
R1 is phenyl;
R2 is selected from the group consisting of methyl, ethyl, p-aminophenyl, p-chlorophenyl, m-chlorophenyl, m-fluorophenyl, p-methylphenyl,
andR3, R4, R5, and R6 are each hydrogen;
A is *—C(O)—*; and
n is 1.

US Pat. No. 10,988,435

TREPROSTINIL DERIVATIVES AND COMPOSITIONS AND USES THEREOF

Corsair Pharma, Inc., So...

1. A method of promoting vasodilation, inhibiting platelet activation or aggregation, inhibiting thrombus formation, stimulating thrombolysis, inhibiting atherogenesis, inhibiting cell proliferation, promoting endothelial cell membrane remodeling, reducing inflammation, or providing cytoprotection, comprising administering to a subject in need of treatment a therapeutically effective amount of a compound of Formula (I):
wherein:
R1 and R2 independently are hydrogen,
wherein:R6 in each occurrence independently is hydrogen, R3, —C(?O)R3, —C(?O)OR3 or —C(?O)NR9R10;
R3 in each occurrence independently is alkyl, haloalkyl, -alkylaryl, cycloalkyl, heterocyclyl, aryl or heteroaryl, each of which may optionally be substituted;
R9 and R10 in each occurrence independently are hydrogen, alkyl, -alkylaryl, cycloalkyl, heterocyclyl, aryl or heteroaryl; or
R9 and R10 and the nitrogen atom to which they are connected form a heterocyclic or heteroaryl ring;
j in each occurrence independently is an integer from 0 to 4; and
t in each occurrence independently is an integer from 1 to 9;
with the proviso that:
both R1 and R2 are not hydrogen; and
R1 or R2 is not
or a pharmaceutically acceptable salt, solvate, hydrate, clathrate, polymorph or stereoisomer thereof.

US Pat. No. 10,988,431

UPGRADING LIGNOCELLULOSIC OR CARBOHYDRATE MATERIAL

NESTE OYJ, Espoo (FI)

1. A method for upgrading carbohydrates, carbohydrate derivatives or lignocellulosic material, the method comprising:providing a feedstock containing carbohydrates, carbohydrate derivatives or lignocellulosic material, wherein the carbohydrates, carbohydrate derivatives, or lignocellulosic material include(s) angelica lactone; and
dimerising and oligomerising the carbohydrates, carbohydrate derivatives, or lignocellulosic material at a reaction temperature in a range of 30° C. to 195° C., in a presence of a heterogeneous catalyst to produce a dimer and oligomer product;
wherein the oligomerising constitutes formation of trimers or higher and wherein the content of trimers or higher is 30 area-% or more in a Gel Permeation Chromatography (GPC) chromatogram relative to the sum of dimers and oligomers in the dimer and oligomer product,
wherein the lignocellulosic material is levulinic acid, an ester of levulinic acid and/or a dehydration product of levulinic acid,
wherein the heterogeneous catalyst is an inorganic catalyst containing an alkali metal compound and at least one further metal compound, or is an inorganic catalyst containing an alkali metal compound and an alkaline earth metal compound and at least one further metal compound, and
wherein the further metal constituting the at least one further metal compound is at least one selected from the group consisting of Al, Si, Sc, Ti, V, Y, Zr, Nb, Mo, La, Ce, Hf, Ta and W.

US Pat. No. 10,988,427

OLEFIN AND METHANOL CO-PRODUCTION PLANT AND OLEFIN AND METHANOL CO-PRODUCTION METHOD

Mitsubishi Heavy Industri...

1. An olefin and methanol co-production plant for co-production of an olefin and methanol from a source gas containing methane, comprising:an olefin production unit for producing the olefin; and
a methanol production unit for producing methanol from a carbon oxide gas in the olefin production unit,
wherein the olefin production unit includes a partial oxidative coupling device for producing the olefin by partial oxidative coupling reaction of methane contained in the source gas,
wherein the methanol production unit includes
a reforming device for producing hydrogen by reforming reaction of methane, and
a methanol production device for producing methanol by reaction with hydrogen produced by the reforming device, and
wherein at least one of the reforming device or the methanol production device is configured to perform reaction using the carbon oxide gas in the olefin production unit.

US Pat. No. 10,988,424

METHOD FOR PREPARING HALOGEN-SUBSTITUTED STYRENE MONOMER

LG Chem, Ltd.

1. A method for preparing a styrene monomer comprising:preparing a styrene monomer of the following Chemical Formula 2 by reacting a compound represented by the following Chemical Formula 3 in the presence of phosphoric acid,
wherein the phosphoric acid is used in 100 mol % or greater based on 100 mol % of the compound represented by the following Chemical Formula 3:

in Chemical Formula 2,
at least one of X1 to X5 is a halogen group; and
the remaining X1 to X5 are the same as or different from each other, and each independently hydrogen; deuterium; or a halogen group,

in Chemical Formula 3,
at least one of X1 to X5 is a halogen group; and
the remaining X1 to X5 are the same as or different from each other, and each independently hydrogen; deuterium; or a halogen group.

US Pat. No. 10,988,418

COPPER-CERAMIC SUBSTRATE, COPPER PRECURSOR FOR PRODUCING A COPPER-CERAMIC SUBSTRATE AND PROCESS FOR PRODUCING A COPPER-CERAMIC SUBSTRATE

1. A copper ceramic substrate, comprising:a ceramic carrier; and
a copper layer joined to a surface of the ceramic carrier,
wherein the copper layer comprises:
at least one first layer;
wherein the at least one first layer faces the ceramic carrier and has a first average grain size, and
a second layer;
wherein the second layer is arranged on a face of the copper layer facing away from the ceramic carrier and has a second average grain size,
wherein the second average grain size is smaller than the first average grain size, and
wherein:
a) the first average grain size is in a range of from 250 ?m to 1000 ?m, and the second average grain size is less than 100 ?m; or
b) the first average grain is in a range of from 250 ?m to 2000 ?m, and the second average gram size is less than 150 ?m.

US Pat. No. 10,988,416

COLLOIDAL VESICLES FOR USE AS DEDUSTING AGENTS IN CONSTRUCTION PANELS

UNITED STATES GYPSUM COMP...

12. A wallboard having a layer produced from a slurry, the slurry comprising:calcium sulfate hemihydrate at 88 wt % to 99.6 wt %;
vesicle dedusting agent at about 0.01 wt % to about 10 wt %, wherein the vesicle dedusting agent comprises vesicles;
at least one dispersant at about 0.01 wt % to about 2 wt %; and
water at a ratio of water to dry components of about 1:6 to about 1:1.

US Pat. No. 10,988,415

DISPERSANT FOR CALCIUM SULPHATE-BASED COMPOSITIONS

SIKA TECHNOLOGY AG, Baar...

1. A method comprising introducing a copolymer as a dispersant into a binder composition that includes at least one mineral binder, the binder composition being based on calcium sulfate, whereinthe copolymer comprises a polymer backbone and side chains bonded thereto and there are at least one ionizable monomer unit M1 and at least one side chain-bearing monomer unit M2,
the copolymer has a nonrandom distribution of the monomer units Ml and/or the monomer units M2 in a direction along the polymer backbone in that the copolymer has a gradient structure in at least one section AA in a direction along the polymer backbone with respect to the ionizable monomer unit M1 and/or with respect to the side chain-bearing monomer unit M2, and the copolymer, in addition to the at least one section AA having a gradient structure, has a further section AB, wherein there is essentially a constant local concentration of the monomers and/or a statistical or random distribution of the monomers over the entire section AB,
a proportion of the calcium sulfate, based on all the mineral binder in the binder composition, is at least 30% by weight,
a molar ratio of the monomer units Ml to the monomer units M2 in the copolymer is in the range of 0.5-6,
the ionizable monomer unit M1 in the copolymer has a structure of the formula I
the side chain-bearing monomer unit M2 includes a structure of the formula IIwhereR1 forms a ring together with R4 to give —CO—O—CO—, or R1, in each case independently, is —COOM and/or —SO2-0M, and R4, in each case independently, is H, —COOM or an alkyl group having 1 to 5 carbon atoms;
M, independently of one another, represents H+, an alkali metal ion, an alkaline earth metal ion, a di- or trivalent metal ion, an ammonium ion or an organic ammonium group;
R2, R3, R5 and R6, in each case independently, are H or an alkyl group having 1 to 5 carbon atoms;
R7, in each case independently, is H, —COOM or an alkyl group having 1 to 5 carbon atoms;
m=0, 1 or 2;
p=0 or 1;
X, in each case independently, is —O— or —NH—;
R8 is a group of the formula -[AO]n—Ra, where A=C2? to C4-alkylene, Ra is H, a Cl- to C20-alkyl group, -cycloalkyl group or -alkylaryl group; and
n=2-250.

US Pat. No. 10,988,412

FORMALDEHYDE-FREE BINDER COMPOSITIONS AND METHODS OF MAKING THE BINDERS UNDER CONTROLLED ACIDIC CONDITIONS

Johns Manville, Denver, ...

1. A method of making a fiberglass product, the method comprising:combining a binder composition and glass fibers, wherein the binder composition includes:
an aldehyde or ketone,
an amino-amide compound that consists of a reaction product of a diamine and a carbonyl compound, wherein the diamine is selected from the group consisting of 1,2-ethylenediamine, 1,3-propanediamine, 1,4-butanediamine, 1,5-pentadiamine, and 1,6-hexanediamine, and
a catalyst for catalyzing a reaction between (i) the aldehyde or ketone and (ii) the amino-amide compound;
forming the combination of the binder composition and the glass fibers into an uncured fiberglass mat or batt; and
heating the uncured fiberglass mat or batt into the fiberglass product.

US Pat. No. 10,988,411

METHOD AND APPARATUS FOR DRYING AND COOLING GLASS SUBSTRATE

WUHAN CHINA STAR OPTOELEC...

1. An apparatus for drying and cooling a glass substrate, the apparatus comprising a baking oven and a cooling chamber arranged side by side, and the apparatus further comprising:a first roller device, installed on a bottom plate of the baking oven, used for moving the glass substrate in the baking oven;
a second roller device, installed on a bottom plate of the cooling chamber, used for moving the glass substrate dried by the baking oven in the cooling chamber;
a plurality of infrared heating plates, installed at inside of a top plate of the baking oven; and
a plurality of cooling plates, installed at inside of a top plate of the cooling chamber;
wherein both the top plate of the baking oven and the top plate of the cooling chamber are movable;
wherein the top plate of the baking oven has a first free end near the cooling chamber, and the top plate of the cooling chamber has a second free end near the baking oven; the top plate of the baking oven and the top plate of the cooling chamber both are movable upwards in a manner of the first free end and the second free end being moved away from each other.

US Pat. No. 10,988,408

CONVERSION MATERIAL FOR WHITE OR COLORED LIGHT SOURCE, METHOD OF PRODUCTION, AND LIGHT SOURCE HAVING THE CONVERSION MATERIAL

SCHOTT AG, Mainz (DE)

1. A conversion material for a white or colored light source, comprising:a matrix glass comprising a lanthanum borosilicate glass with a zinc fraction; and
at least one luminophore,
wherein the matrix glass and the at least one luminophore are formed as a sintered compact from a powder of the matrix glass, the powder having a grain size distribution d10?0.7 ?m, d50?3 ?m and d90?150 ?m.

US Pat. No. 10,988,406

FLUOROPHOSPHATE GLASSES FOR ACTIVE DEVICE

KOREA PHOTONICS TECHNOLOG...

1. Fluorophosphate glasses for an active device, comprising:a metaphosphate composition including Mg(PO3)2 of about 20 mol % to about 60 mol %;
a fluoride composition including BaF2 of about 20 mol % to about 60 mol % and CaF2 of about 0 mol % to about 40 mol %; and
dopants including rare earth elements,
wherein the dopants are ErF3 and YbF3, the ErF3 is about 3 mol %, and the YbF3 is about 3 mol % to about 6 mol %.

US Pat. No. 10,988,400

TRANSPARENT SEALING MEMBER

NGK Insulators, Ltd., Na...

1. A transparent sealing member made of quartz glass, the transparent sealing member being used in an optical component having at least one optical element and a mounting substrate on which the optical element is mounted, and constituting, together with the mounting substrate, a package in which the optical element is accommodated;wherein a surface portion of the transparent sealing member indicates a region that is formed at a depth of 0.05 to 0.20 ?m from a surface of the transparent sealing member facing away from the mounting substrate and an interior portion of the transparent sealing member indicates a region that is formed at a depth of 1 to 5 ?m from the surface of the transparent sealing member facing away from the mounting substrate so as to be between the surface portion and a surface of the transparent sealing member facing the mounting substrate, the surface portion and the interior portion contain aluminum, and an aluminum concentration of the surface portion of the transparent sealing member is higher than an aluminum concentration of the interior portion thereof.

US Pat. No. 10,988,399

ARTICLES COMPRISING CRYSTALLINE MATERIALS AND METHOD OF MAKING THE SAME

3M Innovative Properties ...

1. A method for making an article comprising crystalline material, the method comprising:heating nanocrystalline glass-ceramic particulate at sufficient temperature and under sufficient pressure such that the nanocrystalline glass-ceramic particulate consolidates to form a shape having at least 90 percent of theoretical density; and
cooling the consolidated shape to provide the article,
wherein at least 90 percent by weight of the nanocrystalline glass-ceramic particulate, based on the total weight of the nanocrystalline glass-ceramic particulate, does not have a Tg.

US Pat. No. 10,988,395

CERIUM-LANTHANUM TREATMENT METHOD FOR REDUCTION OF CONTAMINANTS IN WASTEWATER MEMBRANE BIOREACTORS

1. A method for treating wastewater using a membrane bioreactor comprising:dosing a wastewater stream, as part of a membrane bioreactor system, containing a first concentration of phosphorus with a dose amount of a rare earth clarifying agent to obtain a dosed wastewater stream, the first concentration of phosphorus being greater than a target concentration of phosphorus; and
passing the dosed wastewater stream through a membrane of the membrane bioreactor system to obtain a membrane permeate stream, the membrane permeate stream having a permeate concentration of phosphorus less than the first concentration phosphorus.

US Pat. No. 10,988,392

METHOD AND SYSTEM FOR OPTIMIZATION OF COAGULATION AND/OR FLOCCULATION IN A WATER TREATMENT PROCESS

KEMIRA OYJ, Helsinki (FI...

1. A computerized method for monitoring and/or optimization of coagulation and/or flocculation in a water treatment process, the method comprising:taking samples from an aqueous liquid;
monitoring the samples with an imaging device to capture visual data of particles dispersed or suspended in said liquid;
classifying particle types based on said visual data;
computing a particle size distribution indication for at least one classified particle type; and
comparing said particle size distribution indication to a predetermined particle size distribution value;
wherein the method comprises at least one of:
a) computing a particle size distribution indication for flocs, and comparing the particle size distribution indication for flocs to a predetermined particle size distribution value;
b) computing a particle count for microparticles, and comparing said particle count for microparticles to a predetermined particle count value; or
c) monitoring the samples with the imaging device to capture visual data of compounds dissolved in the liquid, computing water color of the samples based on the visual data, and comparing the computed water color to a predetermined water color value;
wherein the method further comprises:
adjusting, at least partially in response to a difference detected in any one or combination of the comparing steps, a dosage of at least one coagulation and/or flocculation agent in the water treatment process to optimize the coagulation and/or flocculation of the particles dispersed or suspended in the liquid.