US Pat. No. 10,508,263

METHODS FOR ISOLATING HUMAN CARDIAC VENTRICULAR PROGENITOR CELLS

Procella Therapeutics AB,...

1. A method for generating human ventricular muscle cells in vivo in a subject using engraftable human cardiac ventricular progenitor cells (HVPs), the method comprising:contacting a culture of day 5-7 cardiac progenitor cells (CPCs) comprising HVPs with one or more first agents reactive with at least one first marker selected from the group consisting of TRA-1-60, TRA-1-81, TRA-2-54, SSEA1, SSEA3, SSEA4, CD9, CD24, E-cadherin, Podocalyxin, and combinations thereof, and with one or more second agents reactive with a second marker selected from the group consisting of JAG1, LIFR, FGFR3, TNFSF9 and combinations thereof, wherein the culture is contacted with the one or more second agents either before, simultaneously with or after contacting with the one or more first agents,
wherein the culture of day 5-7 CPCs has been obtained by subjecting human pluripotent stem cells to activation of Wnt/?-catenin signaling on day 0, followed by inhibition of Wnt/?-catenin signaling from day 3 to day 5;
isolating first marker negative/second marker positive cells to thereby isolate a cell population comprising engraftable HVPs,
administering the cell population comprising engraftable HVPs to a subject;
wherein the cell population comprising engraftable HVPs forms a vascularized, electrically responsive ventricular muscle patch that secretes an extracellular matrix in the subject; and
detecting cardiac function in the subject indicative of engraftment of the isolated cell population comprising engraftable HVPs.
US Pat. No. 10,508,265

CELL-PERMEABLE REPROGRAMMING FACTOR (ICP-RF) RECOMBINANT PROTEIN AND USE THEREOF

CELLIVERY THERAPEUTICS, I...

1. A recombinant protein, which comprises a RF protein selected from the group consisting of OCT4, SOX2, CMYC, KLF4, NANOG, LIN28 and ZSCAN4, and an advanced macromolecule transduction domain (aMTD) being composed of 12 amino acid residues and having improved cell or tissue permeability,wherein the aMTD has an amino acid sequence selected from the group consisting of SEQ ID NOs: 39, 43, 84, 96, 131, 223, 226, and 233, or the aMTD is encoded by a polynucleotide sequence selected from the group consisting of SEQ ID NOs: 279, 283, 324, 336 371, 463, 466, and 473.
US Pat. No. 10,507,243

NANOPARTICLE COMPLEXES OF RITUXIMAB, ALBUMIN AND PACLTAXEL

Mayo Foundation for Medic...

1. An antibody-albumin nanoparticle complex, the nanoparticle complex comprising albumin, a rituximab antibody, and paclitaxel, wherein the nanoparticle complex has been pre-formed in vitro by mixing an aqueous albumin-paclitaxel nanoparticle with the antibody under conditions to form the nanoparticle complex, such that the nanoparticle complex has CD20 binding specificity, said complex having a diameter of between 0.1 ?m and 1 ?m.
US Pat. No. 10,508,267

MUTANT 3-HYDROXYBUTYRATE DEHYDROGENASE FROM ALCALIGENES FAECALIS AS WELL AS METHODS AND USES INVOLVING THE SAME

Roche Diagnostics Operati...

1. A mutant 3-hydroxybutyrate dehydrogenase (3-HBDH) from Alcaligenes faecalis with improved performance relative to the wild-type 3-HBDH, wherein the mutant comprises an amino acid sequence that is at least 80% identical to the amino acid sequence of SEQ ID NO: 1 (3-HBDH from Alcaligenes faecalis; wild-type 3-HBDH) or the amino acid sequence of SEQ ID NO: 2 (extended core sequence of wild-type 3-HBDH) andwherein the mutant has at least three amino acid substitutions relative to the wild-type 3-HBDH, wherein the amino acid at the position corresponding to
position 253 of SEQ ID NO: 1 is substituted with Ile (253Ile), Ala (253Ala) or Cys (253Cys),
position 233 of SEQ ID NO: 1 is substituted with Ser (233Ser), Ile (233Ile), Ala (233Ala), Pro (233Pro), Arg (233Arg), Thr (233Thr), Lys (233Lys), or Cys (233Cys), and
position 234 of SEQ ID NO: 1 is substituted with Thr (234Thr), wherein improved performance relative to the wild-type 3-HBDH is
increased thermal stability relative to the wild-type 3-HBDH; and/or
increased substrate affinity relative to the wild-type 3-HBDH; and/or
increased cofactor affinity.
US Pat. No. 10,509,035

ANTIBODIES, ANTIBODY DRUG CONJUGATES AND METHODS OF USE

GAMAMABS PHARMA SA, Toul...

1. An antibody drug conjugate (ADC) comprising a humanized antibody conjugated to bis-sulfone-PEG(24)-val-cit-paraaminobenzyl monomethyl auristatin E, said humanized antibody binding AMHR-II and comprising a light chain comprising SEQ ID NO: 14 and a heavy chain comprising SEQ ID NO: 16.
US Pat. No. 10,507,247

OPTICAL PROBES FOR MATRIX METALLOPROTEINASES

The University of the Uni...

1. An optical probe comprising at least one fluorophore connected to at least one quencher by an enzyme cleavable peptide sequence; the at least one fluorophore being substantially fluorescently quenched by the at least one quencher when connected to the enzyme cleavable peptide sequence; wherein the at least one fluorophore is separated from the at least one quencher when the enzyme cleavable peptide sequence of at least one probe element is cleaved; wherein the enzyme cleavable peptide sequence is an amino acid sequence of SEQ ID NO:7 and is selectively cleavable by one or more matrix metalloproteinase (MMP).
US Pat. No. 10,508,271

TARGETED MUTATIONS

GREEN BIOLOGICS LIMITED, ...

1. A process for producing a mutation in an Intended Mutagenesis Region (IMR) within a bacterial genome, wherein the bacteria are of the class Clostridia, wherein the bacteria comprise a CRISPR/Cas system, and wherein the IMR comprises a CRISPR PAM/Protospacer which is capable of being recognised by the bacteria's CRISPR/Cas systems, the process comprising the steps:(a) transforming a population of said bacteria with a Recombination Vector, wherein the Recombination Vector comprises a Recombination Element, wherein the Recombination Element comprises:
(i) a Substitution Element, wherein the Substitution Element comprises the mutation, and
(ii) Homology Arms which flank the Substitution Element, wherein the Homology Arms are capable of promoting the replacement of all or part of the IMR in the bacterial genome with an element which comprises the Substitution Element,
wherein the Recombination Element does not comprise a CRISPR PAM/Protospacer which is capable of being recognised by a crRNA which recognises the CRISPR/PAM Protospacer in the IMR;
(b) culturing the population of bacteria under conditions wherein, in one or more bacteria within the population, all or part of the IMR in the genomes of those bacteria is replaced by an element which comprises the Substitution Element and whereby the CRISPR PAM/Protospacer is removed from the IMR in the genomes of those bacteria or is rendered incapable of being recognised by a crRNA which recognises the CRISPR/PAM Protospacer in the IMR;
(c) transforming the population of bacteria with a Killing Vector which is capable of directing production of a crRNA which targets the CRISPR PAM/Protospacer in the IMR of any bacteria in the population from which the CRISPR PAM/Protospacer has not been removed or rendered incapable of being recognised by the crRNA, thereby promoting the CAS endonuclease-induced cleavage of those CRISPR PAM/Protospacers in the genomic DNA which are recognised by the crRNA and the subsequent death of those bacteria; and
(d) selecting or isolating one or more bacteria from the population whose genomes comprise the Substitution Element comprising the mutation.
US Pat. No. 10,509,040

METHOD FOR MEASURING GLYCEMIC INDEX OF HUMAN-CONSUMED FOOD

Healbe Corporation, Redw...

1. A method for determining a glycemic index of multicomponent food consumed by a human, the method comprising:measuring a blood glucose concentration in the human from an onset of increase of a blood glucose concentration caused by intake of the food by the human until the blood glucose concentration reaches its peak;
using measurements obtained in the previous step to measure a time interval ?t from the onset to the peak of the blood glucose concentration, to determine a maximum increase of a blood glucose concentration ?Gmax over the time interval ?t, and to calculate a carbohydrate content Csum of the food consumed by the human, wherein the carbohydrate content Csum is =K·?t·?Gmax, and wherein a proportionality factor K ranges from 0.35 to 0.6 g/min·mmol/l; and
determining the glycemic index of the food consumed by the human as a ratio ?Gmax/?G(gl)max, wherein ?G(gl)max is a maximum presumptive increase of a blood glucose concentration upon intake by the human of pure glucose in an amount equal to the carbohydrate content Csum.
US Pat. No. 10,508,273

METHODS FOR IDENTIFYING SELECTIVE BINDING PAIRS

Inscripta, Inc., Boulder...

1. A method of producing a cell library expressing engineered peptides for identification of peptides that bind to a target of interest, the method comprising:providing a population of cells;
processing the population of cells using an instrument for multiplexed nuclease-directed genome editing using introduced nucleic acids and a nucleic acid-directed nuclease to create cells comprising nucleic acids that encode engineered peptides each comprising an N-terminus or C-terminus cell surface display conferring tag;
incubating the processed cells to facilitate nucleic acid editing in the cells, wherein the editing provides nucleic acids that encode engineered peptides each comprising an N-terminus or C-terminus cell surface display conferring tag in the cells; and
allowing the cells to express and display the engineered peptides on the surface of the cells.
US Pat. No. 10,508,274

PROTEIN AND PEPTIDE LIBRARIES

The General Hospital Corp...

1. A method for linking an mRNA molecule to a polypeptide, the method comprising:(a) providing an mRNA molecule comprising a reactive nucleoside that is reactive with a crosslinker, wherein the crosslinker is an S-4 alkylated thiouridine comprising N-(2-acetamidophenyl)-2-bromoacetamide at the S-4 position of the alkylated thiouridine;
(b) providing a translation system comprising a linking aminoacyl-tRNA comprising an amino acid residue linked to a linking tRNA by an amide bond, wherein the linking tRNA comprises an anticodon comprising the crosslinker;
(c) translating the mRNA molecule in the translation system to produce a polypeptide into which the amino acid residue, still linked to the tRNA, is incorporated; and
(d) during or after step (c), crosslinking the reactive nucleoside of the mRNA molecule to the crosslinker of the anticodon of the linking tRNA, thereby linking the mRNA molecule to the polypeptide through the linking tRNA.
US Pat. No. 10,509,042

IDENTIFICATION OF GLYCOSYLATION FORMS

DH Technologies Developme...

1. A method of analyzing a sample, comprising:separately reacting portions of a sample with a plurality of glycosidases each of which is effective to cleave a different glycosidic bond, the sample containing a plurality of a glycopeptide of interest comprising a glycan bonded to a peptide;
differentially labeling products of each reaction between the glycopeptide and the glycosidase;
mixing the differentially labeled products to form a mixture;
performing liquid chromatography-mass spectrometry on the mixture of differentially labeled products;
determining if a cleaved glycan portion resulted from the reaction of the glycopeptide with each of the plurality of glycosidases;
at least partially determining a structure of the glycan based on the determination of whether a cleaved glycan portion resulted from the reaction of the glycopeptide with each of the plurality of glycosidases; and
comparing a mass of non-cleaved glycan portions remaining bonded to the peptide after each separate reaction with known glycan structures to at least partially determine the structure of the glycan.
US Pat. No. 10,508,275

METHOD FOR THE CONSTRUCTION OF SPECIFIC PROMOTERS

Synpromics Ltd., Edinbur...

1. A method for making a transcription-enhancing combined promoter cassette, the method comprising:(a) identifying a plurality of transcription factor regulatory elements (TFREs), wherein each of the plurality of TFREs is associated with a plurality of genes, each of which is differentially expressed in a particular cell type or tissue type, or under a particular condition;
(b) determining the frequency, length and SYN value for each of said plurality of TFREs provided in step (a), and selecting TFREs from among the plurality of TFREs provided in step (a), wherein each of the selected TFREs (1) is within 20 kilobases of more than fifty percent of the plurality of genes defined in step (a), and (2) has a SYN value larger than 0.3, wherein the SYN value of a TFRE is defined as frequency(1/length), wherein frequency is defined as the number of occurrences of a given TFRE being associated with any of the plurality of genes, divided by the total number of all TFREs associated with any of the plurality of genes, and wherein the frequency is its frequency within 20 kilobases of any of the plurality of the genes and length is the length in nucleotides of the TFRE;
(c) constructing a library of randomly combined elements by randomly combining TFREs selected in step (b); and
(d) inserting combined elements from the library of (c) in a vector with a minimum promoter and a reporter gene, thereby generating a transcription-enhancing combined promoter cassette.
US Pat. No. 10,507,252

NANOPARTICLE PROBES AND METHODS OF MAKING AND USE THEREOF

1. A nanoparticle probe comprising:a nanoparticle base structure; and
a slip bond moiety comprising a binding motif for a glycocalyx and having a binding strength to the glycocalyx of less than about 100 pN, wherein the slip bond moiety is configured to reversibly bind to the glycocalyx of a cell;
a polymeric tether functionalized to the nanoparticle base structure and to an associative moiety comprising a cell surface binding moiety configured to bind to a one or more of a cell surface protein, receptor, and/or biomarker of the cell with a binding strength of larger than 100 pN;
wherein the associative moiety preferentially binds to the protein, receptor, and/or biomarker of the cell based on the thickness of a glycocalyx layer of the cell.
US Pat. No. 10,507,254

IMAGE-GUIDED RADIOTHERAPY METHOD FOR TREATING A SUBJECT HAVING A TUMOR

National Guard Health Aff...

1. An image-guided radiotherapy method for treating a subject having a tumor, comprising:injecting a biocompatible curable composition into the subject at a tumor location such that the biocompatible curable composition is in contact with a border of the tumor, wherein the biocompatible curable composition crosslinks upon exposure to an aqueous solution or moisture to form a three-dimensional cured nanocomposite which is covalently bonded to the border of the tumor and forms a tissue spacer to separate the tumor from non-tumor tissue proximal to the tumor;
imaging the three-dimensional cured nanocomposite by at least one of magnetic resonance imaging, computed tomography, ultrasound, and X-ray, wherein the border of the tumor is detected; and
exposing the three-dimensional cured nanocomposite to radiation to weaken or destroy cells in the tumor;
wherein the biocompatible curable composition comprises:
an organic polymer comprising at least one hydrolysable functional group selected from the group consisting of a silane and an isocyanate;
a solvent selected from the group consisting of hexane and toluene; and
a metallic nanoparticle, wherein the metallic nanoparticle is at least one of a manganese-based nanoparticle and a gadolinium-based nanoparticle, and is dispersed in the organic polymer and the solvent at a weight percent relative to the total weight of the biocompatible curable composition of 0.1% to 30%.
US Pat. No. 10,508,278

SORTILIN 1 IS A NOVEL INDUCER OF VASCULAR CALCIFICATION

1. A method for inhibiting calcification of a smooth muscle cell (SMC), the method comprising contacting an anti-sortilin antibody or an antigen binding fragment thereof with a SMC, wherein the compound antibody or antigen binding fragment thereof inhibits activity or amount of sortilin 1 in the smooth muscle cell.
US Pat. No. 10,507,257

INORGANIC GEL FOR CONTROLLED RELEASING OF FRAGRANCE AND DISINFECTANT

THE HONG KONG UNIVERSITY ...

1. A method for preparing an air freshener or disinfectant gel composition that releases the air freshener or disinfectant at a steady rate over a period of at least one month to the surrounding environment, comprising:preparing a first component consisting of a silica sol solution, by performing one of the following: hydrolyzing at least one silicon alkoxide by blending with water or an acidic or basic aqueous solvent, preparing a suspension of at least one colloidal silica, or a combination thereof;
adding at least one water-soluble or water-miscible solvent to the silica sol solution to form a first solution;
adding a second component to the first solution, the second component being selected from the group consisting of a volatile component, a gaseous disinfectant, and a combination thereof, and mixing to form a second solution, wherein the volatile component is selected from the group consisting of fragrances, deodorizers, essential oils, insect repellants, and combinations thereof;
adding a base aqueous solvent to the second solution to form a third solution;
transferring the third solution to a container and sealing the container to prevent evaporative loss of the second component; and
facilitating condensation and solidification of the third solution to form the gel composition in the container,
whereby the gel composition is transparent having a light transmittance of at least 80% as measured spectrophotometrically in a range of 500 nm to 800 nm, and has an elasticity allowing more than 25% compression without cracking.
US Pat. No. 10,508,281

DISRUPTION OF ROCK1 GENE LEADS TO PLANTS WITH IMPROVED TRAITS

1. A method for producing a plant with an improved yield-related trait the method comprising:introducing into the genome of a plant cell a disruption of endogenous ROCK1 gene, wherein said disruption inhibits expression and/or activity of a product of said endogenous ROCK1 gene compared to a corresponding plant cell lacking such a disruption, wherein the endogenous ROCK1 gene comprises:(a) a nucleic acid encoding a ROCK1 protein comprising the amino acid sequence of SEQ ID NO: 1 or 2 or an orthologue thereof;(b) a nucleic acid encoding a ROCK1 protein comprising an amino acid sequence with a sequence identity of at least 55% over the entire amino acid sequence with SEQ ID NO: 1 or 2;(c) a nucleic acid comprising one of the nucleic acid sequences with SEQ ID NO: 4, 5, 6, 7 and/or 8;(d) a nucleic acid comprising a nucleic acid with a sequence identity of at least 60% over the entire nucleic acid sequence with one of SEQ ID NO: 4, 5, 6, 7 and/or 8; or(e) a nucleic acid hybridizing under stringent conditions to one of the nucleic acid sequences defined under (a), (b), (c), and/or (d);regenerating a plant having such an altered genome from said plant cell; and
measuring a yield-related trait of said plant compared to a plant lacking such disruption, wherein the yield-related trait is selected from the group consisting of: number of flowers, number of siliques, shoot growth, and seed yield.
US Pat. No. 10,509,310

PATTERNING DEVICES FOR USE WITHIN A LITHOGRAPHIC APPARATUS, METHODS OF MAKING AND USING SUCH PATTERNING DEVICES

ASML Netherlands B.V., V...

1. A patterning device carrying a pattern of features to be transferred onto a target portion of a substrate using a lithographic apparatus and a resist process, at least an area of the patterning device being free of radiation absorber material and configured to define features of the pattern in that area by phase differences alone, wherein an individual feature in the area is defined at least in one direction by a pair of edges between regions having a phase different than that between the edges, and wherein a distance between the pair of edges is at least 15% smaller than a size of an associated feature to be formed on the substrate in the resist process once adjusted by a magnification factor, if any, of the lithographic apparatus.
US Pat. No. 10,508,287

METHOD FOR REGENERATING T CELLS AND APPLICATIONS THEREOF

Guangzhou Institutes of B...

1. A method for transdifferentiating B lymphoid cells into functional T cells, comprising:(1) introducing a nucleic acid molecule encoding Hoxb5 or a construct comprising the nucleic acid molecule into the B lymphoid cells by transfection or virus infection to obtain transformed B lymphoid cells with overexpressed Hoxb5;
(2) implanting the transformed B lymphoid cells obtained in step (1) into the body of a subject to induce transdifferentiation to obtain T cell progenitor cells, which then differentiate to obtain functional T cells.
US Pat. No. 10,507,265

CANCELLOUS BONE PRODUCT INCLUDING VIABLE OSTEOGENIC CELLS

NuVasive, Inc., San Dieg...

1. A bone product, comprising:cancellous bone matrix essentially free of hematopoietic cells, said cancellous bone matrix including native, viable osteogenic cells;
demineralized bone matrix; and
a cryopreservative;
wherein the cancellous bone matrix has been treated to partially digest the cancellous bone matrix and enhance availability of the native, viable osteogenic cells for carrying out their osteogenic function.
US Pat. No. 10,507,524

METALLIC COPPER DISPERSION, METHOD FOR MANUFACTURING SAME, AND USAGE FOR SAME

ISHIHARA SANGYO KAISHA, L...

1. A metallic copper dispersion liquid comprising at least metallic copper particles having a gelatin on surfaces thereof, a polymeric dispersant, and an organic solvent, whereinthe polymeric dispersant has an amine value of 18 to 61 mgKOH/g, a glass transition point within a range of ?65.7 to ?8.7° C., and a specific heat capacity of 1.40 to 1.77 J/(g·K) at a glass transition point of the polymeric dispersant, and
the metallic copper particles have, in the dispersion liquid, a 50% cumulative particle diameter (D50) of 67 to 94 nm and a 90% cumulative particle diameter (D90) of 139 to 200 nm, wherein the gelatin on the surfaces of the metallic copper particles comprises a collagen peptide having a molecular weight of 3000 to 5000.
US Pat. No. 10,508,294

ASSAYS AND OTHER REACTIONS INVOLVING DROPLETS

President and Fellows of ...

1. A composition comprising a plurality of droplets in an emulsion, wherein a droplet of the plurality of droplets comprises a cell and a particle, wherein the particle comprises one or more reagents for facilitating a reaction on a nucleic acid molecule of the cell.
US Pat. No. 10,508,295

GAMMA GLUTAMYL-VALINE SYNTHASE, AND METHOD FOR PRODUCING GAMMA GLUTAMYL-VALYL-GLYCINE

AJINOMOTO CO., INC., Tok...

1. A method for producing ?-Glu-Val-Gly and/or a salt thereof, the method comprising:contacting a protein and glutathione synthetase with Glu, Val, and Gly to produce ?-Glu-Val-Gly; and
collecting the produced ?-Glu-Val-Gly,
wherein the protein comprises an amino acid sequence having at least 97% sequence identity to the amino acid sequence of SEQ ID NO: 6, 10, or 16, and has ?-glutamylvaline synthetase activity, and
a ratio of ?-glutamylvaline synthetase activity of the protein to ?-glutamylglycine synthetase activity of the protein is 15 or higher.
US Pat. No. 10,509,319

PHOTOSENSITIVE COMPOSITION AND COLOR CONVERTING FILM

Merck Patent GmbH, Darms...

1. A photosensitive composition, comprising: at least one nanosized fluorescent material, a polymer mixture of polysiloxane and a (meth)acrylic polymer, and a wetting and dispersing additive, wherein said wetting and dispersing additive comprises a polymer unit.
US Pat. No. 10,506,759

RICE SEED TREATMENT AGENT

KUMIAI CHEMICAL INDUSTRY ...

9. A method for controlling paddy field weeds, said method comprising sowing and cultivating the paddy seed(s) according to claim 8.
US Pat. No. 10,508,297

METHOD FOR IMMOBILIZATION OF GLUCURONIDASE ENZYMES FOR THE DETECTION OF PRODUCTS DERIVED FROM GLUCURONIDE COMPOUNDS

1. An insoluble enzymatic reagent for detecting products derived from glucuronide metabolites in a sample, comprising a ?-glucuronidase enzyme originated from a bacterium of the genus Brachyspira sp., the enzyme being immobilized on a resin of a polysaccharide activated with an aldehyde functional group, wherein said polysaccharide is agarose and said aldehyde functional group is a glyoxyl group.
US Pat. No. 10,508,045

PROCESS AND COMPOSITION FOR CONVERTING LIQUID HYDROCARBONS AND FATTY SUBSTANCES TO SOLID FORM, DEVICES FOR IMPLEMENTING THIS PROCESS AND MANUFACTURING THIS COMPOSITION, AND THE USE THEREOF FOR ENVIRONMENTAL REMEDIATION

CALUDE SARL, Luxembourg ...

1. A process to convert substantially liquid hydrocarbons or fatty substances to solid form, for the remediation of surfaces or sites polluted with these hydrocarbons or fatty substances, comprising contacting the matter to be converted to solid form with a composition in the liquid state comprising ovine or bovine tallow at least in majority proportion and optionally a fluidizing agent, thereby obtaining a solid complex material, the liquid state of said composition being obtained by heating said composition to a temperature of at least 45° C., wherein immediately before said contacting, the matter to be solidified is pretreated to improve the distribution of said composition within the matter, said pretreatment comprising sprinkling said matter to be solidified with an acid, the volume of said acid being 10% or lower of the total volume of composition used, said pretreatment being carried out in a zone at a short distance ahead of the zone in which the matter to be solidified is contacted with the composition in liquid form, and wherein said acid is a short-chain organic acid.
US Pat. No. 10,508,301

DETECTION OF 5-HYDROXYMETHYLCYTOSINE BY GLYCOSYLATION

THE UNITED STATES OF AMER...

1. A method comprising:contacting a mammalian nucleic acid sequence with an enzyme that utilizes a labeled glucose or a labeled glucose-derivative donor substrate to add a labeled glucose molecule or a labeled glucose-derivative to a 5-hydroxymethylcytosine in said mammalian nucleic acid sequence to generate a labeled glucosylated-5-hydroxymethylcytosine, wherein said enzyme comprises a beta-glucosyltransferase and wherein said labeled glucose or said labeled glucose-derivative donor substrate comprises a uridine diphosphate glucose (UDPG).
US Pat. No. 10,508,302

CONTROL PREPARATION FOR FISH METHODS IN MICROBIOLOGY

CHARITE UNIVERSITATSMEDIZ...

1. A control preparation for use in a method for detection of a target microorganism in microbiological pathology,characterized in that
the control preparation comprises a plurality of section bodies, wherein the section bodies are joined by a joining polymer, and wherein each section body comprises a matrix polymer, and wherein
(a) a first section body comprises a first nucleic acid sequence, which is 100% identical to a nucleic acid sequence comprised in the target microorganism;
(b) a second section body comprises a second nucleic acid sequence, which in comparison to said first nucleic acid sequence, contains a deletion, an additional nucleotide or a different nucleotide in one, two, three or four positions of said second nucleic acid sequence;
wherein said joining polymer and said matrix polymer comprise, or are made of, a polymethacrylic acid alkyl ester,
and wherein the control preparation is positioned on a microscopic sample holder and each section body is positioned within the control preparation so that the identity of the section body can be identified unambiguously by its position relative to
(i) a shape of the control preparation;
(ii) a shape of said sample holder and/or
(iii) a reference point disposed on said sample holder.
US Pat. No. 10,508,303

WHOLE-GENOME AND TARGETED HAPLOTYPE RECONSTRUCTION

LUDWIG INSTITUTE FOR CANC...

1. A method for haplotyping one or more chromosomes of a eukaryotic organism, the method comprising:providing a cell of the organism that contains a set of chromosomes having genomic DNA;
incubating the cell or the nuclei thereof with a fixation agent for a period of time to allow crosslinking of the genomic DNA in situ and thereby to form crosslinked genomic DNA;
fragmenting the crosslinked genomic DNA;
ligating the proximally located crosslinked and fragmented genomic DNA to form a proximally ligated complex having a first genomic DNA fragment and a second genomic DNA fragment,
wherein the first genomic DNA fragment and the second genomic DNA fragment are on the same chromosome, and
wherein the first genomic DNA fragment and the second genomic DNA fragment are apart in situ by at least 100 bp;
shearing the proximally ligated complex to form proximally-ligated DNA fragments;
obtaining a plurality of the proximally-ligated DNA fragments to form a library;
sequencing the plurality of the proximally-ligated DNA fragments to obtain a plurality of sequence reads and
assembling the plurality of sequence reads to construct a haplotype for one or more of the chromosomes.
US Pat. No. 10,508,304

HIGH THROUGHPUT GENOME-WIDE TRANSLOCATION SEQUENCING

1. A method for high throughput, genome-wide translocation sequencing (HTGTS) and identification of double-stranded DNA break (DSB) locations comprising the steps of:a. exposing a cell to an agent known or suspected to be capable of producing a DSB;
b. optionally allowing the cell to divide for at least 12 hours;
c. extracting genomic DNA from the cells;
d. producing a fragmented DNA sample by fragmenting the DNA of the cell with a frequently cutting restriction enzyme;
e. producing a ligated DNA sample by ligating the fragmented DNA at a concentration favoring intra-molecular ligation, thereby providing circularized DNA fragments;
f. digesting the ligated DNA sample with a blocking restriction enzyme, wherein the blocking restriction enzyme is different than the restriction enzyme of step d), thereby providing:
i. circularized DNA fragments comprising translocations or DSBs; and
ii. linearized DNA fragments not comprising translocations or DSBs;
g. producing nested PCR products by performing a nested PCR with locus-specific primers on the products of step f.;
h. sequencing the nested PCR products; and
i. aligning the sequences against a reference sequence to identify chromosomal locations of the translocations or DSBs.
US Pat. No. 10,508,307

METHODS OF DIAGNOSING CHRONIC OBSTRUCTIVE PULMONARY DISEASE (COPD) USING NOVEL MOLECULAR BIOMARKERS

1. A method of diagnosing and treating a human subject that is prone to develop progressive COPD, the method comprising the steps of:a) obtaining a lung biopsy sample obtained from the human subject;
b) assaying the level of transcription of DMBT1, KIAA1199 and TMSB15A in the lung biopsy sample obtained from the human subject;
c) diagnosing the human subject as prone to progressive COPD based on increased levels of transcription of DMBT1 and KIAA1199, and a decreased level of transcription of TMSB15A, in the lung biopsy as compared to the level of transcription of DMBT1, KIAA1199 and TMSB15A in a lung biopsy from a healthy human subject; and
d) administering a drug that is effective to treat COPD to the human subject diagnosed as prone to progressive COPD.
US Pat. No. 10,508,308

ASSAYS FOR DIAGNOSING TYPE 1 DIABETES

L2 Disgnostics, LLC, New...

1. A method of diagnosing whether a subject has or is at risk of developing type 1 diabetes comprising the steps of:(a) isolating genomic islet-specific glucose-6-phosphatase catalytic subunit-related (IGRP) DNA from a biological sample comprising serum obtained from a subject and treating the isolated DNA with bisulfate;
(b) contacting the bisulfite-treated DNA with an appropriate amount of a composition comprising a combination recombinant, double quencher probe pair and primer pair containing nucleotide sequences indicative of the methylation status of said bisulfite-treated DNA to form a reaction mixture, wherein said probe pair comprises a first probe and a second probe,
said first probe comprising a fluorescent dye at the 5? end of the first probe, a first quencher inserted within the first probe, and a second quencher at the 3? end of the first probe,
said second probe comprising a fluorescent dye at the 5? end of the second probe, a first quencher inserted within the second probe, and a second quencher at the 3? end of the second probe, and
said first probe and said second probe comprise different fluorescent dyes;
(c) loading the reaction mixture into a droplet generator;
(d) depositing the droplets generated onto a plate and transferring the plate into a polymerase chain reactor for amplification by droplet digital polymerase chain reaction (ddPCR);
(e) transferring the plate into a droplet reader for analysis of the ddPCR;
(f) detecting the ratio of unmethylated IGRP DNA copy number to total or methylated IGRP DNA copy number; and
(g) diagnosing the subject as having or at risk of developing type I diabetes where said subject has an increased ratio of unmethylated IGRP DNA copy number to total or methylated IGRP DNA copy number compared to a control value.
US Pat. No. 10,508,309

METHODS FOR DETECTING AND TREATING VARIANTS OF SEBORRHEIC KERATOSES

THE GENERAL HOSPITAL CORP...

1. A method of treating a keratoacanthoma in a subject, the method comprising(a) receiving the results of an assay distinguishing a keratoacanthoma cell(s) from a squamous cell carcinoma in a skin sample, wherein the results are generated by the steps of:
(i) assaying a level of FOXN1 in a skin sample obtained from a subject, wherein the skin sample is a skin biopsy taken from the part of the skin suspected of having a keratoacanthoma;
(ii) detecting an increase in the level of FOXN1 of at least 10% as compared to the level of FOXN1 in a sample of normal skin cells, thereby detecting a keratoacanthoma cell(s) in the skin sample, and
(b) administering a therapeutically effective amount of a composition comprising kaempferol, ellipticine, nutlin-3 or pyromycin to the subject.
US Pat. No. 10,511,637

AUTOMATED MITIGATION OF ELECTRONIC MESSAGE BASED SECURITY THREATS

ServiceNow, Inc., Santa ...

9. A method comprising:receiving, by a security decision point application, a message from an email server device having a spam filter, wherein the message was not classified as spam by the spam filter but suspected to be a phishing attack;
parsing, by the security decision point application, the message for an observable indicator of a phishing attack;
querying, by the security decision point application, a security threat database for the observable indicator, wherein the security threat database is configured to determine whether the observable indicator is associated with known phishing attacks;
receiving, by the security decision point application, a result of the determination from the security threat database; and
in response to the result indicating that the observable indicator is not associated with the known phishing attacks, transmitting, by the security point application, an update to the spam filter to classify a future message having the observable indicator as spam.
US Pat. No. 10,506,772

COTTON VARIETY PX333103W3FE

Phytogen Seed Company LLC...

1. A seed of cotton variety designated PX333103W3FE, or a regenerable part thereof, representative seed of the variety having been deposited under ATCC Accession No. PTA-123649 on Nov. 15, 2016.
US Pat. No. 10,508,054

TRANSPORT VEHICLE GLAZING WITH WATER REPELLENT AND ANTI-DUST COATING ASSOCIATED WITH A DETECTION DEVICE

SAINT-GOBAIN GLASS FRANCE...

1. A transport vehicle glazing comprising a first side to face an interior of a transport vehicle and a second side to face an exterior atmosphere, the second side being opposite the first side, at least one zone of the second side not wiped by windscreen wipers and facing the exterior atmosphere, and said at least one zone being located to face a detecting device placed in the interior of the transport vehicle,wherein the transport vehicle glazing comprises a substrate and a mineral oxide layer provided on the substrate,
the mineral oxide layer being of 0.1 to 20 ?m thickness, wherein 30% to 90% of the volume of the mineral oxide layer consists of 20 to 300 nm open pores that are distributed uniformly throughout the thickness of the mineral oxide layer, and a majority of the open pores are connected to one another, an internal surface and an external surface of the mineral oxide layer being functionalized with a compound containing a perfluoroalkyl or alkyl functional group, saturated with a hydrophobic oil that impregnates the functionalized porous layer and forms a film on the surface thereof, and
wherein the mineral oxide layer is made of silica and formed at least in the zone of the second side not wiped by windscreen wipers and facing the exterior atmosphere.
US Pat. No. 10,508,310

METHOD OF PREDICTING A RESPONSE TO AN ANTI-TUMOR TREATMENT

SORBONNE UNIVERSITE, Par...

1. A method for treating a tumor in a patient, which method comprisesa) determining expression level of at least each of VIM, MK167, TCF7L2, NEK2, BIRC5, MCL1, and PLK1 genes, in a biological sample of a patient with a tumor, wherein a decreased expression of said genes compared to control values for said genes is indicative of a patient being likely to respond to a treatment with a chimeric peptide comprising i) a pro-apoptotic peptide that comprises SEQ ID NO: 4 or SEQ ID NO: 1 fused at the C-terminus to ii) a cell-penetrating peptide that comprises a sequence selected from the group consisting of SEQ ID NO: 26, 27, 28 and 29; and
b) administering said chimeric peptide to a patient having decreased expression of at least each of VIM, MK167, TCF7L2, NEK2, BIRC5, MCL1, and PLK1 genes compared to control values for said genes.
US Pat. No. 10,508,311

SINGLE MOLECULE-OVERLAPPING READ ANALYSIS FOR MINOR VARIANT MUTATION DETECTION IN PATHOGEN SAMPLES

The Translational Genomic...

1. A method of detecting a drug-resistant subpopulation within a heteroresistant population of a pathogen in a sample, the method comprising:a) providing a sample comprising a population of the pathogen;
b) extracting nucleic acids from the sample;
c) amplifying a target locus of the genome of the pathogen in the extracted nucleic acids to generate paired overlapping nucleic acid strands from a single DNA molecule, wherein the target locus comprises a region of interest comprising at least one minor variant associated with drug resistance of the drug-resistant subpopulation in the pathogen and each of the paired overlapping nucleic acid strands comprise the region of interest;
d) consecutively sequencing the paired overlapping nucleic acid strands amplified from the same single DNA molecule of the target locus on a Next Generation Sequencing (NGS) platform to interrogate the region of interest of the single DNA molecule resulting in paired overlapping reads for the at least one minor variant;
e) applying an alignment algorithm to sequencing data from the paired overlapping nucleic acid strands; and
f) performing an analysis of the aligned sequencing data to detect the at least one minor variant, wherein the at least one minor variant is detected when present in the paired overlapping reads from the paired overlapping nucleic acid strands.
US Pat. No. 10,506,774

MAIZE INBRED PH2SKK

PIONEER HI-BRED INTERNATI...

1. A seed, plant, plant part, or plant cell of inbred maize variety PH2SKK, representative seed of the variety having been deposited under ATCC accession number PTA-125653.
US Pat. No. 10,508,312

COMPOSITIONS AND METHODS FOR DETECTING ZIKA VIRUS NUCLEIC ACID

GEN-PROBE INCORPORATED, ...

1. A combination of at least two amplification oligomers for amplifying a Zika virus nucleic acid in a sample, the oligomer combination comprising:at least two amplification oligomers configured to amplify a target sequence corresponding to a Zika virus target nucleic acid, wherein the target sequence consists of SEQ ID NO: 189 or SEQ ID NO: 190, the RNA equivalent of SEQ ID NO: 189 or SEQ ID NO: 190, or the DNA or RNA complement of SEQ ID NO: 189 or SEQ ID NO: 190,
wherein the first amplification oligomer and the second amplification oligomer are configured to hybridize to opposite ends of the target sequence to generate amplification products;
wherein the first amplification oligomer comprises (i) a target-hybridizing sequence consisting of from 17 to 26 contiguous nucleobases of SEQ ID NO: 24, wherein said contiguous nucleobases of the target-hybridizing sequence include SEQ ID NO: 25, or (ii) a target-hybridizing sequence consisting of SEQ ID NO: 27, and
wherein the second amplification oligomer comprises a target-hybridizing sequence that is selected from the group consisting of SEQ ID NO: 113, SEQ ID NO: 115, SEQ ID NO: 126, and SEQ ID NO: 128, wherein the second amplification oligomer target-hybridizing sequence is joined at its 5? end to a T7 promoter sequence.
US Pat. No. 10,506,775

MAIZE INBRED PH42CD

PIONEER HI-BRED INTERNATI...

1. A seed, plant, plant part, or plant cell of inbred maize variety PH42CD, representative seed of the variety having been deposited under ATCC accession number PTA-125654.
US Pat. No. 10,508,313

COMPOSITIONS AND METHODS FOR DETECTING OR QUANTIFYING HEPATITIS B VIRUS

GEN-PROBE INCORPORATED, ...

1. An amplification oligomer comprising the sequence of SEQ ID NO: 2.
US Pat. No. 10,506,776

MAIZE INBRED PH262F

PIONEER HI-BRED INTERNATI...

1. A seed, plant, plant part, or plant cell of inbred maize variety PH262F, representative seed of the variety having been deposited under ATCC accession number PTA-125655.
US Pat. No. 10,509,338

TWO-COMPONENT DEVELOPER FOR DEVELOPING ELECTROSTATIC LATENT IMAGE

KONICA MINOLTA, INC., To...

1. A two-component developer for developing an electrostatic latent image comprising: toner particles having toner mother particles and an external additive on a surface of the toner mother particles; and carrier particles,wherein the external additive contains alumina particles;
the alumina particles are subjected to a surface modification with a hydrophobilizing agent;among the hydrophobilizing agent existing on the surface of the alumina particles after the surface modification, a ratio of the hydrophobilizing agent in a state of being liberated from the surface is 20% or less when extraction treatment is performed under a predetermined condition;the alumina particles have a number average primary particle diameter in the range of 5 to 60 nm;the carrier particles have a resin covering layer, and the resin covering layer is formed with an alicyclic (meth)acrylate monomer; anda total amount of carbon derived from the hydrophobilizing agent present on the surface of the alumina particles after surface modification is in the range of 0.5 to 10 mass % based on the alumina particles after surface modification.
US Pat. No. 10,506,777

MAIZE HYBRID X05M994

PIONEER HI-BRED INTERNATI...

1. A seed of hybrid maize variety X05M994, the seed produced by crossing a first plant of variety PH2S5H with a second plant of variety PH1W4R, wherein representative seed of the varieties PH2S5H and PH1W4R have been deposited under ATCC Accession Numbers PTA-124787 and PTA-121351, respectively.
US Pat. No. 10,508,059

METHOD OF DEPOSITING ABRADABLE COATINGS UNDER POLYMER GELS

General Electric Company,...

1. A method of depositing an abradable coating on a gas turbine engine component, comprising:forming a slurry mixture comprising at least bi-modal ceramic particulate with up to about 70% by volume of coarse particulate wherein said coarse particulate is at least one of Ln2Si2O7, Ln2SiO5, silica, barium strontium aluminosilicate (BSAS), monoclinic hafnium oxide, rare earth gallium garnet (Ln2Ga2O9) where Ln is at least one of Scandium (Sc), Yttrium (Y), Lanthanum (La), Cerium (Ce), Praseodymium (Pr), Neodymium (Nd), Promethium (Pm), Samarium (Sm), Europium (Eu), Gadolinium (Gd), Terbium (Tb), Dysprosium (Dy), Holmium (Ho), Erbium (Er), Thulium (Tm), Ytterbium (Yb), Lutetium (Lu), and up to about 60% by volume of fine particulate, wherein said fine particulate includes at least one of Ln2Si2O7 or Ln2SiO5 where Ln is at least one of Sc, Y, La, Ce, Pr, Nd, Pm, Sm, Eu, Gd, Tb, Dy, Ho, Er, Tm, Yb, Lu, a dispersant for said ceramic particulate, and a monomer solution, a free-radical initiator compound, a low vapor pressure organic solvent and at least one sinter aid selected from the group consisting of iron, aluminum, titanium, cobalt, nickel, gallium, tin, indium, any compounds thereof, mixtures thereof, or mixtures of compounds thereof;
applying said slurry mixture to at least one of said gas turbine engine component and a mold;
gelling said slurry mixture by polymerizing and crosslinking said slurry mixture to form a firm irreversible gel matrix on said gas turbine component with said monomer solution and said free-radical initiator compound by heating said mold containing at least one of said gas turbine engine component and said slurry mixture to a first temperature between about 30° C.-80° C. before evaporation of said organic solvent;
drying said irreversible gel matrix at a second temperature of between 80° C. to 250° C. to affect a particulate on said gas turbine engine component one of within or removed from said mold; and
sintering said particulate of said dried irreversible gel matrix on said gas turbine engine component at a temperature greater than about 1204° C. and less than about 1357° C. forming a layer of said coating having a thickness greater than about 6 mils and a porosity of about 5 percent to about 50 percent, wherein said sintered layer comprises a doped rare earth disilicate where the sintering aid is a doping composition that dissolves into, and dopes the rare earth disilicate.
US Pat. No. 10,506,779

PLANTS AND SEEDS OF HYBRID CORN VARIETY CH699670

Monsanto Technology LLC, ...

1. A seed of hybrid corn variety CH699670, produced by crossing a first plant of variety CV292720 with a second plant of variety CV589900, wherein representative seeds of said varieties CV292720 and CV589900 are deposited under ATCC Accession Nos. PTA-9834 and PTA-12078, respectively.
US Pat. No. 10,508,317

STEEL PRODUCT AND MANUFACTURING METHOD OF THE SAME

NIPPON STEEL CORPORATION,...

13. A manufacturing method of the steel product according to claim 1, comprising the steps of:heating a steel material to a temperature of 670° C. or more in a manner that an average heating speed between 500° C. to 670° C. is 1° C./s to 5° C./s, which steel material has a chemical composition represented by, in mass %,
C: 0.050% to 0.35%,
Si: 0.50% to 3.0%,
Mn: exceeding 3.0% to 7.5% or less,
P: 0.05% or less,
S: 0.01% or less,
sol. Al: 0.001% to 3.0%,
N: 0.01% or less,
V: 0% to 1.0%,
Ti: 0% to 1.0%,
Nb: 0% to 1.0%,
Cr: 0% to 1.0%,
Mo: 0% to 1.0%,
Cu: 0% to 1.0%,
Ni: 0% to 1.0%,
Ca: 0% to 0.01%,
Mg: 0% to 0.01%,
REM: 0% to 0.01%,
Zr: 0% to 0.01%,
B: 0% to 0.01%,
Bi: 0% to 0.01%, and
the balance: Fe and impurities, and has a metal structure in which volume ratios of bainite and martensite are 90% or more in total and an average value of aspect ratios of bainite and martensite is 1.5 or more;
holding the temperature in a temperature range of 670° C. to 780° C. for 60 s to 1200 s after the heating; and
performing cooling to a temperature of 150° C. or less in a manner that an average cooling speed between the temperature range and 150° C. is 5° C./s to 500° C./s, after the holding.
US Pat. No. 10,506,780

HYBRID CORN VARIETY 79586595

Agrigenetics, Inc., Indi...

1. A seed of the hybrid corn variety 79586595, produced by crossing a first plant of variety SLD34BM with a second plant of variety 7DBDD0188, wherein representative seed of said varieties SLD34BM and 7DBDD0188 have been deposited under ATCC Accession numbers PTA-124282 and PTA-124386, respectively.
US Pat. No. 10,506,781

SOYBEAN VARIETY HLL01452

BASF AGRICULTURAL SOLUTIO...

1. A seed of soybean variety HLL01452, wherein a representative sample of seed of said soybean variety is deposited under ATCC Accession No. PTA-125951.
US Pat. No. 10,508,319

METHOD AND SYSTEM FOR PRODUCING LOW CARBON FERROCHROME FROM CHROMITE ORE AND LOW CARBON FERROCHROME PRODUCED THEREBY

MM Metals USA, LLC, Plym...

1. A method for recovering low carbon ferrochrome from chromite ore comprising:feeding a mixture of feed materials comprising scrap aluminum granules, burnt lime, silica sand, and chromite ore into a plasma arc furnace, said scrap aluminum granules being produced from used beverage containers, said chromite ore containing chromium oxide and iron oxide, said feed materials being in a stoichiometric proportion for reduction of said chromium oxide and iron oxide to form low carbon ferrochrome;
heating said feed materials in said plasma arc furnace to a temperature in the range of approximately 1,650° C. to 1850° C. wherein said aluminum in said aluminum granules acts as a reducing agent to produce an exothermic reaction reducing said chromium oxide and iron oxide in said chromite ore to produce molten low carbon ferrochrome with molten slag floating on top of said molten low carbon ferrochrome; and
extracting said molten low carbon ferrochrome from said plasma arc furnace.
US Pat. No. 10,506,782

SOYBEAN VARIETY 5PLMK17

PIONEER HI-BRED INTERNATI...

1. A plant or a seed of soybean variety 5PLMK17, representative seed of the variety having been deposited under ATCC Accession Number PTA-125057.
US Pat. No. 10,508,320

PROCESS FOR RECOVERING PRIMARY METAL RESIDUE FROM A METAL-CONTAINING COMPOSITION

UNIVERSITY OF LEEDS, Lee...

1. A process for recovering a primary metal residue from a metal-containing composition comprising:(a) preparing a feedstock of the metal-containing composition and an alkali salt;
(b) reductively roasting the feedstock at a roasting temperature for a roasting period to produce a roast;
(c) cooling the roast to produce a roasted mass containing metallic iron or an alloy or compound thereof and soluble metal oxides;
(d) adding an aqueous medium to the roasted mass to form a substantially insoluble product and a first solution of soluble metal oxides;
(e) acid leaching the substantially insoluble product or a fraction thereof to produce a leach residue and a second solution of soluble metal oxides;
(f) roasting the leach residue in the presence of a bisulphate or bicarbonate of an alkali metal or alkaline earth metal to produce a roasted residue; and
(g) hydrometallurgically extracting from the roasted residue the primary metal residue and a third solution of soluble metal oxides.
US Pat. No. 10,506,783

SOYBEAN CULTIVAR 70391206

M.S. Technologies, L.L.C....

1. A plant of soybean cultivar 70391206, representative seed of said soybean cultivar having been deposited under ATCC Accession No. PTA-125376.
US Pat. No. 10,506,784

SOYBEAN CULTIVAR S170171

M.S. Technologies, L.L.C....

1. A plant of soybean cultivar S170171, representative seed of said soybean cultivar having been deposited under ATCC Accession No. PTA-125401.
US Pat. No. 10,506,785

SOYBEAN CULTIVAR S170122

M.S. Technologies, L.L.C....

1. A plant of soybean cultivar S170122, representative seed of said soybean cultivar having been deposited under ATCC Accession No. PTA-125444.
US Pat. No. 10,508,068

PRODUCTION METHOD FOR INCLUSION COMPOUND

NIPPON SODA CO., LTD., T...

1. A method for producing a thermodynamically stable crystal of a clathrate compound, comprising a mixing step of mixing the following component (A), component (B), and component (C); and a heating step:(A): a mixed solvent comprising a first solvent which is at least one solvent selected from the group consisting of water and methanol; and a second solvent which is at least one solvent selected from the group consisting of ethyl acetate, hexane, methyl ethyl ketone, and methanol, the second solvent being a solvent different from the first solvent,
(B): at least one compound selected from the group consisting of 1,1,2,2-tetrakis(4-hydroxyphenyl)ethane and 5-hydroxyisophthalic acid,
(C): at least one compound selected from the group consisting of 2-phenyl-4-methyl-5-hydroxymethylimidazole and 2-ethyl-4-methylimidazole.
US Pat. No. 10,506,787

SOYBEAN VARIETY 01072220

Monsanto Technology LLC, ...

1. A plant of soybean variety 01072220, wherein representative seed of said soybean variety have been deposited under ATCC Accession No. PTA-25851.
US Pat. No. 10,508,069

ACID/SALT SEPARATION

PURAC BIOCHEM B.V., Gori...

1. A method for the recovery of a carboxylic acid that is not succinic acid, the method comprising:providing magnesium carboxylate, wherein the carboxylic acid corresponding with the carboxylate has a solubility in water at 20° C. of 80 g/100 g water or less;
acidifying the magnesium carboxylate with hydrogen chloride (HCl), thereby obtaining a solution comprising carboxylic acid and magnesium chloride (MgCl2);
precipitating the carboxylic acid from the solution comprising the carboxylic acid and MgCl2, thereby obtaining a carboxylic acid precipitate and a MgCl2 solution; and
thermally decomposing the MgCl2 solution at a temperature of at least 300° C., thereby decomposing the MgCl2 to magnesium oxide (MgO) and HCl.
US Pat. No. 10,506,788

SOYBEAN VARIETY 01072292

Monsanto Technology LLC, ...

1. A plant of soybean variety 01072292, wherein representative seed of said soybean variety have been deposited under ATCC Accession No. PTA-125874.
US Pat. No. 10,508,326

HIGH-MANGANESE STEEL WITH SUPERIOR COATING ADHESION AND METHOD FOR MANUFACTURING HOT-DIP GALVANIZED STEEL FROM SAME

POSCO, Pohang-si (KR)

1. A hot-dip galvanized steel sheet comprising:a steel sheet comprising: by weight, C: 0.3-1%, Mn: 8-25%, Al: 1-8%, Si: 0.1-3.0%, Ti: 0.01-0.2%, Sn: 0.06-0.2%, B: 0.0005-0.01%, with the remainder being Fe and inevitable impurities, wherein the steel sheet has an Sn-precipitate layer formed on a surface of the steel sheet; and
a galvanized layer formed on the Sn-precipitate layer of the steel sheet.
US Pat. No. 10,512,166

MANUFACTURING METHOD OF CIRCUIT BOARD AND STAMP

Unimicron Technology Corp...

1. A manufacturing method of a circuit board, comprising:providing a dielectric substrate, wherein a circuit pattern, a dielectric layer covering the circuit pattern, and a conductive via located in the dielectric layer and connected to the circuit pattern are disposed on the dielectric substrate;
forming a photoresist material layer on the dielectric layer;
performing an imprinting process on the photoresist material layer via a stamp to form a patterned photoresist layer, wherein a pressing side of the stamp facing the circuit pattern becomes sticky when subjected to a pressure so as to completely catch and remove a photoresist residue from the photoresist material layer in the imprinting process, wherein a material of the pressing side is a pressure-sensitive adhesive material, and the pressure-sensitive adhesive material becomes sticky when subjected to the pressure;
forming a patterned metal layer on a region exposed by the patterned photoresist layer; and
removing the patterned photoresist layer.
US Pat. No. 10,506,789

SOYBEAN CULTIVAR 61381330

Monsanto Technology LLC, ...

1. A plant of soybean cultivar 61381330, representative seed of said soybean cultivar having been deposited under ATCC Accession No. PTA-125581.
US Pat. No. 10,506,790

PETUNIA-CALIBRACHOA VARIETY SAKPXC024

Sakata Seed Corporation, ...

1. A plant of Petunia-Calibrachoa variety SAKPXC024, wherein a representative sample of plant tissue of SAKPXC024 was deposited under NCMA No. 201907006.
US Pat. No. 10,508,073

METHOD FOR PREPARING ACETAL CARBONYL COMPOUND

Dalian Institute of Chemi...

1. A method for preparing acetal carbonyl compound used as an intermediate for producing ethylene glycol, which comprises a step in which a raw material acetal and carbon monoxide go through a reactor loaded with a catalyst for carrying out a carbonylation reaction; wherein the catalyst contains an acidic microporous silicoaluminophosphate molecular sieve; wherein the chemical composition of the acidic microporous silicoaluminophosphate molecular sieve is expressed as (SixAlyPz)O2, and x is in a range from 0.01 to 0.60, and y is in a range from 0.2 to 0.60, and z is in a range from 0.2 to 0.60, and x+y+z=1; wherein the raw material acetal is expressed as R1O(CH2O)nR2, and n is selected from 1, 2, 3 or 4, and R1 and R2 are independently selected from C1-C3 alkyls; wherein the acidic microporous silicoaluminophosphate molecular sieve is one or more molecular sieves selected from the molecular sieves with framework type of CHA, RHO, LEV, ERI, AEI or AFX.
US Pat. No. 10,508,335

PROCESS FOR PREPARING ELECTROACTIVE MATERIALS FOR METAL-ION BATTERIES

Nexeon Limited, Abingdon...

1. A process for preparing composite particles, the process comprising:(a) providing particulate porous carbon frameworks comprising micropores and/or mesopores, wherein the porous carbon frameworks have a D50 particle diameter of at least 50 ?m;
(b) depositing an electroactive material selected from silicon and alloys thereof into the micropores and/or mesopores of the porous carbon frameworks using a chemical vapour infiltration process in a fluidized bed reactor, to provide intermediate particles; and
(c) comminuting the intermediate particles to provide said composite particles.
US Pat. No. 10,508,083

SUBSTITUTED PIPERIDINE COMPOUND AND USE THEREOF

Takeda Pharmaceutical Com...

1. (2R,3S)-N-ethyl-2-(((cis-4-isopropylcyclohexyl)oxy)methyl)-3-((methylsulfonyl)amino)piperidine-1-carboxamide or a salt thereof.
US Pat. No. 10,508,087

CRYSTALLINE FORMS OF TRISODIUM SUPRAMOLECULAR COMPLEX COMPRISING VALSARTAN AND AHU-377 AND METHODS THEREOF

CRYSTAL PHARMATECH CO., L...

1. Trisodium [3-((1S,3R)-1-biphenyl-4-ylmethyl-3-ethoxycarbonyl-1-butylcarbamoyl) propionate-(S)-3?-methyl-2?-(pentanoyl{2?-(tetrazol-5-ylate)biphenyl-4?-ylmethyl}amino)butyrate] trihydrate in crystalline form.
US Pat. No. 10,508,344

STABILIZED ALKALINE HYDROGEN PEROXIDE FORMULATIONS

1. A formulation for stabilizing hydrogen peroxide, comprising water soluble Zn+2 ions in an ammonical solution at 0.7 to 100 parts per million of an alkaline hydrogen peroxide solution.
US Pat. No. 10,506,809

HERBICIDAL COMBINATION COMPRISING SAFLUFENACIL AND GLUFOSINATE

BASF SE, Ludwigshafen am...

1. A herbicidal combination comprising componentsa) a herbicide A which is 2-chloro-5-[3,6-dihydro-3-methyl-2,6-dioxo-4-(trifluoromethyl)-1-(2H)-pyrimidinyl]-4-fluoro-N-[[methyl-(1-methylethyl)-amino]sulfonyl]benzamide,
b) a herbicide B which is glufosinate or one of its salts, and
c) at least one herbicide C different from herbicides A and B which is selected from the group of diclosulam, cloransulam, flumetsulam, thiencarbazone, flumioxazin, butafenacil, carfentrazone, sulfentrazone, acifluorfen, fomesafen, lactofen, oxyfluorfen, quinclorac, fluroxypyr, 2,4-D, pendimethalin, fenoxaprop, haloxyfop, clethodim, sethoxydim, profoxydim, atrazine, metribuzin, bentazone, benzobicyclon, benzofenap, bicyclopyrone, clomazone, isoxaflutole, mesotrione, pyrasulfotole, pyrazolynate, pyrazoxyfen, sulcotrione, tefuryltrione, tembotrione, topramezone, acetochlor, metolachlor, metazachlor, and flufenacet and
or an agriculturally acceptable enantiomer, salt or ester thereof, wherein a herbicidal mixture of components a and b in combination with component c is synergistic.
US Pat. No. 10,506,812

ALTERING MICROBIAL POPULATIONS AND MODIFYING MICROBIOTA

SNIPR TECHNOLOGIES LIMITE...

1. A method for treating an infection caused by bacterial or archaeal host cells in an organism, the method comprising:(a) contacting the host cells with an engineered nucleic acid for producing a host modifying crRNA (HM-crRNA), and
(b) producing the HM-crRNA in the host cells;wherein(i) the HM-crRNA is operable with a Type I Cas in the host cells, wherein the engineered nucleic acid and the Type I Cas are comprised by a Type I HM-CRISPR/Cas system in the host cells;
(ii) the HM-crRNA comprises a nucleotide sequence that is capable of hybridizing to the target sequence in the host cells to guide the Type I Cas to modify the target sequence in the host cells; and
(iii) wherein the Type I Cas is an endogenous Cas in the host cells;wherein the target sequence is modified by the Type I HM-CRISPR/Cas system and the infection is treated.
US Pat. No. 10,508,094

METHODS FOR PRODUCING FERRIC MALTOL COMPOSITIONS FROM FERROUS HYDROXIDES

SHIELD TX (UK) LIMITED, ...

1. A method for producing a ferric maltol composition comprising reacting ferrous hydroxide with maltol and recovering the ferric maltol that forms.
US Pat. No. 10,506,813

COMPOSITIONS AND METHODS FOR CONTROLLING PLANT-PARASITE NEMATODE

BASF CORPORATION, Florha...

1. A composition having anti-nematodal activity comprising at least one isolated biosurfactant derived from Bacillus firmus and at least one acid precipitate from a culture medium in which the Bacillus firmus was grown.
US Pat. No. 10,508,096

NICOTINE SALTS, CO-CRYSTALS, AND SALT CO-CRYSTAL COMPLEXES

R.J. Reynolds Tobacco Com...

1. A salt-co-crystal of nicotine, L-malic acid, and succinic acid, characterized by an X-ray powder diffraction pattern having peaks at one or more of the following 2-theta diffraction angles: 17.1, 18.7, 20.0, 21.6, 25.1, and 25.4wherein the salt-co-crystal has a stoichiometry of about 2:0.1:0.9 nicotine malate:L-malic acid:succinic acid.
US Pat. No. 10,506,824

SMOKING ARTICLE MOUTHPIECE WITH COOLING AGENT INCLUSION COMPLEX

1. A smoking article comprising;a mouthpiece having an outer surface; and
a cooling agent inclusion complex disposed on the outer surface wherein the cooling agent inclusion complex is a cyclodextrin cooling agent inclusion complex comprising cyclodextrin and a non-volatile cooling agent comprising a carboxamide containing compound.
US Pat. No. 10,508,106

BICYCLIC BET BROMODOMAIN INHIBITORS AND USES THEREOF

ConverGene LLC, Cambridg...

1. A compound, which is (S)-1-(4-(6-(3,5-dimethylisoxazol-4-yl)-4-(3-phenylmorpholino)quinazolin-2-yl)-1H-pyrazol-1-yl)-2-methylpropan-2-ol, or a pharmaceutically acceptable salt thereof.
US Pat. No. 10,508,370

ECONOMICAL FIRE BARRIER NONWOVEN OR FABRIC MATERIAL WITH ANTIMICROBIAL PROPERTIES

TINTORIA PIANA US, INC., ...

1. A fire barrier material, comprising:10-80 wt % of at least one flame retardant (FR) cellulosic fiber, wherein said at least one FR cellulosic fiber contains or is treated with FR chemicals or FR compounds having a melting point or decomposition temperature at 400° C. (752° F.) or below; and
20-80 wt % of at least one untreated cellulosic fiber that is untreated with and does not contain FR chemicals or FR compounds, wherein the cellulosic fiber in the at least one untreated cellulosic fiber is the same as or different from the cellulosic fiber of the at least one FR cellulosic fiber, and
wherein the at least one FR cellulosic fiber and the at least one untreated cellulosic fiber are blended together and converted to a fire barrier nonwoven, or
wherein the at least one FR cellulosic fiber and the at least one untreated cellulosic fiber are blended together and converted to a yarn and the yarn is further converted to a fire barrier woven or knitted fabric.
US Pat. No. 10,507,347

USE OF LEAD SMELTING SLAGS FOR THE STABILIZATION OF METAL IONS FROM SOLID OR LIQUID MEDIA

Redox Technology Group, L...

1. A method of treating, stabilizing, precipitating, or otherwise removing heavy metal ions contained in a contaminated media, which method comprises the steps of:providing a sodium-iron-sulfide mineral or crystalline phase, either alone or in combination with a pH adjusting substance;
contacting said contaminated media containing heavy metal ions with the sodium-iron-sulfide mineral or crystalline phase, either alone or in combination with a pH adjusting substance; and
allowing the contaminated media containing the heavy metal ions to react with said sodium-iron-sulfide mineral or crystalline phase, either alone or in combination with a pH adjusting substance, such that the contaminated media containing heavy metal ions form single or mixed metal-sulfide precipitates or co-precipitates.
US Pat. No. 10,507,608

POLYAMIDE MOULDING COMPOUNDS FOR LARGE MOULDED PARTS

1. A polyamide molding composition with the following composition:(A) 20 to 79% by weight of at least one semiaromatic polyamide in the form of a copolyamide which comprises from 65 to 73 mol % of units composed of hexanediamine and terephthalic acid,
(B) 1 to 15% by weight of at least one impact modifier,
(C) 20 to 60% by weight of at least one carbon fiber,
(D) 0 to 5% by weight of at least one additive,
where components (A) to (D) give a total of 100% by weight
wherein the copolyamide is in essence free from aliphatic diacids.
US Pat. No. 10,508,123

POLYMORPHS

Vectura Limited, Chippen...

1. A method of treating asthma or chronic obstructive pulmonary disease (COPD), comprising administering to a patient in need thereof a polymorph of (S)-3-(3-(1-methyl-2-oxo-5-(pyrazolo[1,5-a]pyridine-3-yl)-1H-imidazo[4,5-b]pyridine-3(2H)-yl)piperidin-1-yl)-3-oxopropanenitrile with the following diffraction angles (2Theta) based on cupric K?1:at approximately 8.25°;
at approximately 13.25°;
at approximately 15.40°;
at approximately 17.65°; and
at approximately 25.39°.
US Pat. No. 10,507,612

MARKED COMPOSITE MATERIAL AND METHOD FOR PRODUCING THE SAME

Teijin Limited, Osaka-Sh...

1. A method of applying laser marking on a composite material comprising a black pigment, carbon fibers, and a resin, and having the following 1) to 3):1) an area proportion of the carbon fibers in a topmost surface layer of the material from 10 to 90%,
2) a proportion of the black pigment contained in the composite material from 0.2 to 20% by mass, and
3) an average fiber length of the carbon fibers from 1 to 100 mm,
wherein the laser marking is applied using a YVO4 laser having a wavelength from 100 to 2,000 nm, an output density from 1.0 (mW/?m2) to 30 (mW/?m2), and an irradiation energy per pulse from 1000×10?5 (mWs) to 50,000×10?5 (mWs).
US Pat. No. 10,508,129

PHARMACEUTICAL TARGETING OF A MAMMALIAN CYCLIC DI-NUCLEOTIDE SIGNALING PATHWAY

THE BOARD OF REGENTS OF T...

1. An injectable pharmaceutical formulation comprising a pharmaceutically acceptable carrier containing a cyclic dinucleotide comprising a 5?-monophosphate nucleotide comprising a guanine moiety, and a 5?-monophosphate nucleotide comprising an adenine moiety, wherein the cyclic dinucleotide hasa phosphodiester bond between the 2?-OH of the nucleotide comprising the guanine moiety and the 5?-phosphate of the nucleotide comprising the adenine moiety, and
a phosphodiester bond between the 3?-OH of the nucleotide comprising the adenine moiety and the 5?-phosphate of the nucleotide comprising the guanine moiety.
US Pat. No. 10,508,130

CRYSTALLINE POLYMORPH OF 15B-HYDROXY-OSATERONE ACETATE

ASKA PHARMACEUTICAL CO., ...

1. A crystalline polymorphic form A of 15?-hydroxy-osaterone acetate, which is a crystalline polymorphic form having diffraction peaks at the following diffraction angles 2? in a powder X-ray diffraction spectrum:9.6°±0.2°, 17.1°±0.2°, 20.2°±0.2°.
US Pat. No. 10,508,387

CONDUCTIVE FIBRES

PIRETA LIMITED, Birmingh...

1. A method for making a fibre electrically conductive, comprising the steps of:(a) providing a fibre having a negative electric charge at the surface of the fibre,
(b) applying to the fibre a substance (referred to below as a ‘linker’) which provides a layer of said substance on the fibre and changes the electric charge at the surface of the fibre from negative to positive, wherein said substance is not chitosan, wherein said substance is a cationic polyelectrolyte,
(c) making the surface of the fibre electrically conductive with a metal,
wherein the metal of step (c) is provided in the form of metal cations and wherein the metal cations are reduced to elemental metal; and
(d) sintering the metal.
US Pat. No. 10,508,132

METHOD FOR PRODUCING AEROBIC-TYPE SINGLE CELL PROTEIN USING THE AUTOLYSIS PROCESS

Taizhou iCell Bio-Tech Co...

1. A method for producing an aerobic-type single cell protein from materials by an autolysis, comprising the following steps:(1) delivering bacterial proteins generated from a bioreactor to a conical concentration tank, and precipitating the bacterial proteins at the bottom of the conical concentration tank, wherein the material moisture content at the bottom is reduced to 97% or less for the subsequent dewatering process;
(2) pumping the materials at the bottom of the concentration tank to centrifugal dewatering equipment by a transfer pump;
(3) performing a solid-liquid separation using a horizontal spiral centrifuge, wherein the material moisture content is reduced to 78% to 85% and the materials are mud-like after the centrifugation;
(4) transferring the materials from step (3) to an autolysis device comprising twin-screw hollow blades, wherein the front ¼ to ½ of the twin-screw front hollow blade of the autolysis device is a heating section and the remaining section is a holding section and the device is preheated through the twin-screw hollow blades to an autolysis temperature of between 65° C. and 95° C. for a preheating time of 5 to 30 min; and carrying out an autolysis, comprising maintaining the materials in the autolysis device at a temperature between 65° C. and 95° C. for a time of 30 to 360 min;
(5) conveying the materials resulting from the autolysis through an auger feeder to air flash drying equipment for drying; wherein the contact temperature of the materials is between 65 and 100° C. and the moisture content of the materials after drying is between 10% and 40%;
(6) conveying the materials from step (5) to a tunnel type microwave drying sterilization apparatus by airflow lifting equipment for sterilization; wherein said materials after the microwave sterilization have a moisture content between 5% and 10%; and
(7) smashing and packaging the materials from step (6);
wherein the aerobic-type single cell protein has 33% -60% of protein, 0.1-1.4% free nucleotides, and 0-0.9% free base, and the ratio of free bases to free nucleotides is between 0 to 0.60.
US Pat. No. 10,508,389

SEPARATOR FOR ELECTROCHEMICAL ELEMENT AND ELECTROCHEMICAL ELEMENT

NIPPON KODOSHI CORPORATIO...

1. A separator, comprising:20% to 80% by mass of natural cellulose fibers A having a length-weighted average fiber length of 0.30 mm to 1.19 mm and a CSF of 500 ml to 50 ml;
10% to 50% by mass of natural cellulose fibers B having a length-weighted average fiber length of 1.20 min to 1.99 mm, a maximum distribution fiber length of 1.20 mm to 1.99 mm, and a CSF of 500 ml to 50 ml; and
10% to 50% by mass of beaten regenerated cellulose fibers,
wherein:
the separator is interposed between a pair of electrodes;
the separator is capable of holding an electrolytic solution comprising an electrolyte; and
the separator has a thickness of 15 ?m to 100 ?m and a density of 0.30 g/cm3 to 0.80 g/cm3.
US Pat. No. 10,508,135

NON-FRET CELL BASED ASSAY

BIOMADISON, INC., Del Ma...

1. A transfected cell comprising:a cytosol;
a nucleic acid comprising a sequence that encodes a first hybrid protein having a structure of A-C-B and a second hybrid protein having a structure of A-C?-D;
wherein A is a transmembrane protein domain of synaptobrevin target to an intracellular vesicle membrane and that is not cleavable by a Botulinum neurotoxin protease, B is a first fluorescent protein, C is a first linking region comprising a Botulinum neurotoxin protease recognition sequence and a Botulinum neurotoxin protease cleavage sequence, C? is second linking region comprising an analog of C that includes the Botulinum neurotoxin protease recognition sequence but not the Botulinum neurotoxin protease cleavage sequence, B is a first fluorescent protein and D is a second fluorescent protein,
wherein the first fluorescent protein is selected to be degradable by a component of the cytosol, selected to form a FRET pair with the first fluorescent protein, and wherein the first fluorescent protein and the second fluorescent protein are selected, oriented, or spaced such that less than or equal to 5% FRET occurs between the first fluorescent protein and the second fluorescent protein when the first hybrid protein and the second hybrid protein are collocated with a vesicle of the transfected cell.
US Pat. No. 10,508,137

DISINTEGRIN VARIANTS AND PHARMACEUTICAL USES THEREOF

NATIONAL CHENG KUNG UNIVE...

1. A disintegrin variant of rhodostomin comprising the amino acid sequence of SEQ ID NO: 1, comprising:a mutant RGD loop, wherein the amino acid sequence at positions 46 to 53 of SEQ ID NO: 1 is substituted with an amino acid sequence selected from the group consisting of SEQ ID NOs: 329, 330, 331, 353, and 354, and
at least one selected from the group consisting of:
(a) a mutant linker, wherein the amino acid sequence at positions 39 to 45 of SEQ ID NO: 1 is substituted with an amino acid sequence selected from the group consisting of SEQ ID NO: 306 to SEQ ID NO: 318; and
(b) a mutant C-terminus, wherein the amino acid sequence at positions 65 to 68 of SEQ ID NO: 1 is substituted with an amino acid sequence selected from the group consisting of SEQ ID NOs: 319, 323, 324, 326, 327, 328, 337, and 352,
wherein the disintegrin variant has an increased selectivity for at least one of ?v?1, ?v?3, ?v?5, ?v?6, ?v?8 and ?5?1 integrins over ?IIb?3 integrin as compared to wild-type rhodostomin having the amino acid sequence of SEQ ID NO: 1.
US Pat. No. 10,508,138

POLYPEPTIDE CAPABLE OF BINDING TO VASCULAR ENDOTHELIAL GROWTH FACTOR, AND USE THEREOF

KOREA ADVANCED INSTITUTE ...

1. A polypeptide capable of binding to vascular endothelial growth factor (VEGF) comprising the amino acid sequence of any one of SEQ ID NOs: 3 to 8.
US Pat. No. 10,508,139

COMPOUND, USE, ANTI-TUMOR PHARMACEUTICAL COMPOSITION, GENE CONSTRUCT FOR POLYPEPTIDE EXPRESSION, PROCESS FOR THE PRODUCTION, PROCESS FOR THE EVALUATION OF TUMOR CELLS, METHOD OF SENSITIZATION OF TUMOR CELLS TO CHEMOTHERAPEUTIC

1. An anti-tumor pharmaceutical composition for extracellular administration comprising:pharmaceutically acceptable carrier;
at least one polypeptide consisting of SEQ ID No: 1; and
cisplatin.
US Pat. No. 10,508,140

PEPTIDE HAVING HAIR GROWTH-PROMOTING ACTIVITY AND/OR MELANIN GENERATION-PROMOTING ACTIVITY, AND USE THEREOF

CAREGEN CO., LTD., Anyan...

1. A peptide having an activity to stimulate hair production or melanogenesis, the peptide consisting of the amino acid sequence of SEQ ID NO: 1 or SEQ ID NO: 2, optionally wherein (i) the C-terminal end of the peptide is modified by the presence of an amino group or an azide group, or (ii) the N-terminal end of the peptide comprises a protecting group.
US Pat. No. 10,508,141

NUCLEIC ACIDS ENCODING HLA-A24 AGONIST EPITOPES OF MUC1-C ONCOPROTEIN

The USA, as represented b...

1. An isolated nucleic acid encoding a peptide comprising the amino acid sequence of SEQ ID NO:1 or SEQ ID NO:2.
US Pat. No. 10,508,397

ANTI-EROSION SYSTEM MADE OF GEOSYNTHETIC MATERIAL

SICORNETE-FIOS E REDES, L...

1. An anti-erosion system made of geo-synthetic material comprising:a) yarn weft manufactured of a polypropylene and polyethylene mixture in a fraction of 50% to 90% of polypropylene and in a fraction of 10% to 50% of polyethylene, said yarn weft being a braiding of filaments, individually placed in braids around a core of filaments manufactured from a mixture of polypropylene and polyethylene in a fraction of 50% to 90% of polypropylene and in a fraction of 10% to 50% of polyethylene; and
b) top and edge sewn with a polyethylene braided thread of ultrahigh molecular weight.
US Pat. No. 10,508,143

COMPOSITIONS AND METHODS FOR TREATMENT OF CANCER

Aleta Biotherapeutics Inc...

1. A T-cell comprising a constitutive expression construct encoding a secreted fusion protein comprising (a) an antibody, or antigen-binding fragment thereof, that binds a tumor antigen; and (b) an extracellular domain of CD19, or a fragment thereof, that includes an epitope recognized by the FMC63 anti-CD19 antibody.
US Pat. No. 10,507,632

PACKAGING FILM

1. A wrapper made of an unstretched at least single-layer polyolefin film which optionally has release properties, comprisinga) a layer (a) with thickness from 6 to ?20 ?m,
based on a mixture of ?) from 20 to 49% by weight of a polypropylene or of at least one propylene copolymer, or of a combination thereof, and
of ?) from 80 to 51% by weight of at least one polyethylene or ethylene copolymer, or of a combination thereof, and
optionally of ?) conventional auxiliaries,
wherein the ?) component has a VICAT temperature of at least 130° C., as measured by ASTM D 1525-00, Rate A (50° C./min), Loading 1 (10 N), and
b) optionally on at least one surface of the layer (a) a release coating (b) made of cured polysiloxane
and
c) optionally on at least one uncovered surface of the layer (a) an optionally sealable layer (c) with thickness from 4 to 10 ?m made of a thermoplastic polymer with melting point lower by at least 5° C. than the melting point of the layer (a),
wherein the tensile strength of the polyolefin film in machine direction is at least 6.5 N/cm, measured in accordance with DIN EN ISO 527-3.
US Pat. No. 10,508,144

CARBOHYDRATE CONTENT OF CTLA4 MOLECULES

Bristol-Myers Squibb Comp...

1. A composition comprising cytotoxic T lymphocyte antigen 4-Ig (CTLA4-Ig) molecules, wherein the CTLA4-Ig composition comprises(a) an average molar ratio of N-acetyl neuraminic acid (NANA) to CTLA4-Ig molecules of from about 8 to about 12, and
(b) less than or equal to 5.0 area percent high molecular weight species as determined by size exclusion chromatography and spectrophotometric detection,
wherein the CTLA4-Ig molecules are isolated from a soluble fraction of a liquid culture medium comprising an initial population of CTLA4-Ig molecules recombinantly produced by mammalian cells, wherein
(1) the CTLA4-Ig molecules of the initial population have one or more sialic acid residues;
(2) the number of sialic acid residues per CTLA4-Ig molecule varies within the initial population;
(3) the initial population comprises CTLA4-Ig dimers and high molecular weight aggregates;
(4) the liquid culture medium contains Monocyte Chemotactic Protein-1 (MCP-1); and,
(5) the CTLA4-Ig molecules comprise one or more polypeptides having the amino acid sequence set forth in SEQ ID NO: 2, 5, 6, 7, 8, 9, or 10,
wherein the CTLA4-Ig composition is obtainable by a method comprising:
(i) obtaining the soluble fraction of the liquid culture medium, wherein the liquid culture medium comprises mammalian cells that produce the initial population of CTLA4-Ig molecules; then
(ii) subjecting the soluble fraction of the liquid culture medium to affinity chromatography to reduce MCP-1 content; then
(iii) subjecting the composition of step (ii) to anion chromatography to separate the CTLA4-Ig molecules into two or more fractions, wherein at least one fraction has a greater molar ratio of sialic acid to CTLA4-Ig molecules compared to at least one other fraction; and then
(iv) subjecting the composition of step (iii) to hydrophobic interaction chromatography to separate CTLA4-Ig dimers from CTLA4-Ig high molecular weight aggregates.
US Pat. No. 10,508,145

ANTIBODY-MEDIATED NEUTRALIZATION OF CHIKUNGUNYA VIRUS

VANDERBILT UNIVERSITY, N...

1. A method of detecting a Chikungunya virus infection in a subject comprising:(a) contacting a sample from said subject with an antibody or antibody fragment comprising clone-paired heavy and light chain CDR sequences as set out below:
Clone 1H12 (VH CDRs consisting of SEQ ID NOS: 103-105; and VL CDRs consisting of SEQ ID NOS: 187-189);
Clone 4N12 (VH CDRs consisting of SEQ ID NOS: 124-126; and VL CDRs consisting of SEQ ID NOS: 208-210);
Clone 2H1 (VH CDRs consisting of SEQ ID NOS: 109-111; and VL CDRs consisting of SEQ ID NOS: 193-195);
Clone 4J14 (VH CDRs consisting of SEQ ID NOS: 118-120; and VL CDRs consisting of SEQ ID NOS: 202-204);
Clone 3N23 (VH CDRs consisting of SEQ ID NOS: 115-117; and VL CDRs consisting of SEQ ID NOS: 199-201);
Clone 5O14 (VH CDRs consisting of SEQ ID NOS: 130-132; and VL CDRs consisting of SEQ ID NOS: 211-213); or
Clone 3E23 (VH CDRs consisting of SEQ ID NOS: 112-114; and VL CDRs consisting of SEQ ID NOS: 196-198); and
(b) detecting Chikungunya virus glycoprotein E2 in said sample by binding of said antibody or antibody fragment to E2 in said sample.
US Pat. No. 10,508,146

SCFV-FC DIMERS THAT BIND TRANSFORMING GROWTH FACTOR-BETA1 WITH HIGH AFFINITY, AVIDITY AND SPECIFICITY

GENZYME CORPORATION, Cam...

1. An isolated binding protein that binds TGF?1, wherein the isolated binding protein is a dimer formed from a polypeptide chain having the formula of, from N-terminus to C-terminus:(VH domain)-(linker1)-(VL domain)-(linker2)-(hinge)-(Fc region),whereinthe VH domain comprises a heavy chain complementarity determining region (HCDR) 1 having the amino acid sequence of SEQ ID NO: 22, an HCDR2 having the amino acid sequence of SEQ ID NO: 23, and an HCDR3 having the amino acid sequence of SEQ ID NO: 24, 25, 26, or 30; and the VL domain comprises a light chain complementarity determining region (LCDR) 1 having the amino acid sequence of SEQ ID NO: 27 or the amino acid sequence of SEQ ID NO: 27 with an A2S substitution, an LCDR2 having the amino acid sequence of SEQ ID NO: 28, and an LCDR3 having the amino acid sequences of SEQ ID NO: 29;
the linker1 is a [G4S]3-type linker;
the linker2 is SEQ ID NO: 20 or a variant thereof, wherein the variant differs from SEQ ID NO: 20 in length by one to four amino acids, or differs from SEQ ID NO: 20 by having up to two amino acid substitutions from glycine to serine or from serine to glycine; and
the hinge comprises an amino acid sequence from a human IgG1 or IgG4 hinge region, or the amino acid sequence of SEQ ID NO: 7 or 21.
US Pat. No. 10,508,147

ANTI-NODAL ANTIBODIES AND METHODS OF USING SAME

1. A method of detecting Nodal in a sample, comprising contacting the sample with an antibody comprising:(a) a hypervariable region (HVR)-H1 comprising the amino acid sequence of
SEQ ID NO: 7;
(b) an HVR-H2 comprising the amino acid sequence of SEQ ID NO: 8;
(c) an HVR-H3 comprising the amino acid sequence of SEQ ID NO: 9;
(d) an HVR-L1 comprising the amino acid sequence of SEQ ID NO: 4;
(e) an HVR-L2 comprising the amino acid sequence of SEQ ID NO: 5; and
(f) an HVR-L3 comprising the amino acid sequence of SEQ ID NO: 6.
US Pat. No. 10,508,148

ANTI-TREM2 ANTIBODIES AND RELATED METHODS

Pionyr Immunotherapeutics...

1. An isolated anti-TREM2 humanized antibody comprising a human IgG1 Fc, a heavy chain comprising a variable heavy (VH) chain sequence comprising three heavy chain CDR sequences, CDR-H1, CDR-H2, and CDR-H3, and a light chain comprising a variable light (VL) chain sequence comprising three light chain CDR sequences, CDR-L1, CDR-L2, and CDR-L3, wherein:a. CDR-H1 comprises the sequence set forth in SEQ ID NO: 9,
b. CDR-H2 comprises the sequence set forth in SEQ ID NO:10,
c. CDR-H3 comprises the sequence set forth in SEQ ID NO: 11,
d. CDR-L1 comprises the sequence set forth in SEQ ID NO: 12,
e. CDR-L2 comprises the sequence set forth in SEQ ID NO: 13, and
f. CDR-L3 comprises the sequence set forth in SEQ ID NO: 14.
US Pat. No. 10,508,149

ANTIBODIES DIRECTED AGAINST T CELL IMMUNOGLOBULIN AND MUCIN PROTEIN 3 (TIM-3)

AnaptysBio, Inc., San Di...

1. A T Cell Immunoglobulin and Mucin Domain-3 (TIM-3) binding agent comprisinga light chain CDR1 comprising RASQSIRRYLN (SEQ ID NO: 332);
a light chain CDR2 comprising GASTLQS (SEQ ID NO: 333);
a light chain CDR3 comprising QQSHSAPLT (SEQ ID NO: 334);
a heavy chain CDR1 comprising GFTFSSYDMS (SEQ ID NO: 329);
a heavy chain CDR2 comprising ISGGGTYTYYQDSVKG (SEQ ID NO: 330); and
a heavy chain CDR3 comprising MDY (SEQ ID NO: 331).
US Pat. No. 10,508,150

METHODS TO IMPAIR HEMATOLOGIC CANCER PROGENITOR CELLS AND COMPOUNDS RELATED THERETO

University of Kentucky Re...

1. A method for reducing the number of CD123-bearing leukemia cells in a human diagnosed with myelodysplastic syndrome, said method comprising administering to the human a therapeutically effective amount of an antibody that binds CD123, such that said administration causes a reduction in the number of leukemia cells in the human.
US Pat. No. 10,508,153

ANTIBODIES DIRECTED TO THE DELETION MUTANTS OF EPIDERMAL GROWTH FACTOR RECEPTOR AND USES THEREOF

Amgen Fremont Inc., Frem...

1. An isolated polynucleotide molecule:(a) comprising a nucleotide sequence encoding the heavy chain amino acid sequence selected from the group consisting of: SEQ ID NOs: 2, 4, 5, 7, and 10, or encoding a heavy chain amino acid sequence, or a fragment thereof, selected from the group consisting of SEQ ID NOs: 142, 9, 12, 13, 15, 16 and 17, wherein the fragment comprises a CDR1 that is a CDR1 in the heavy chain amino acid sequence, a CDR2 that is a CDR2 in the heavy chain amino acid sequence, and a CDR3 that is a CDR3 in the heavy chain amino acid sequence; or
(b) consisting of a nucleotide sequence encoding a fragment of the heavy chain amino acid sequence selected from the group consisting of SEQ ID NOs: 2, 4, 5, 7 and 10, wherein the fragment comprises a CDR1 that is a CDR1 in the heavy chain amino acid sequence, a CDR2 that is a CDR2 in the heavy chain amino acid sequence, and a CDR3 that is a CDR3 in the heavy chain amino acid sequence.
US Pat. No. 10,510,458

LITHIATED CARBON PHOSPHONITRIDE EXTENDED SOLIDS

The Government of the Uni...

1. A material comprising a polymer of lithiated carbon phosphonitride and consisting essentially of Li, C, P, and N.
US Pat. No. 10,508,155

METHOD FOR CONTINUOUSLY PRODUCING CELLULOSE ETHER

SHIN-ETSU CHEMICAL CO., L...

1. A method for continuously producing a cellulose ether, the method comprising:a contact step of bringing pulp into contact with an alkali metal hydroxide solution in the presence of dimethyl ether as a heat removal solvent to obtain alkali cellulose;
a reaction step of subjecting the alkali cellulose to a reaction with an etherifying agent to obtain cellulose ether;
a partial condensation step, after completion of the reaction, of partially condensing a gas present in a reaction vessel used for the reaction with a partial condenser to separate the gas into a gas component and a liquid component containing 20 to 60% by weight of water for returning some or all of the gas component to the contact step for reuse as some or all of the heat removal solvent; and
an incineration step of incinerating the liquid component and any remainder of the gas component that has not been returned to the contact step.
US Pat. No. 10,508,156

CATALYST COMPOSITIONS AND THEIR USE FOR HYDROGENATION OF NITRILE RUBBER

ARLANXEO DEUTSCHLAND GMBH...

1. A process of hydrogenating a nitrile rubber comprisinga) preparing the catalyst composition by contacting a complex catalyst based on ruthenium or osmium as central metal and bearing at least one carbene ligand which is bound to the ruthenium or osmium central metal with at least one co-catalyst in a molar ratio of the complex catalyst to the co-catalyst in the range of 1:(20 to below 100) wherein the co-catalyst must contain at least one vinyl group and thereafter
b) hydrogenating the nitrile rubber in the presence of the catalyst composition formed in step a) as hydrogenation catalyst,
wherein the co-catalyst has the general formula (1)
CH2?CRR?  (1)
in which R and R? are identical or different and shall mean hydrogen or OR1
wherein
R1 shall mean alkyl, cycloalkyl, alkenyl, alkynyl, aryl, or heteroaryl, C(?O)(R2), —C(?O)N(R2)2, —[(CH2)n—X]mR2, —[(CH2)n—X]m—CH?CH2, or —(CH2)p—C(R3)2R4
wherein
X is identical or different and means oxygen (O) or NR2
R2 are identical or different and represent H, alkyl, cycloalkyl, alkenyl, alkynyl, aryl, or heteroaryl,
R3 are identical or different and represent C1-C8 alkyl or —(CH2)n—O—CH?C2,
R4 represents (CH2)p—O—CH?CH2,
n is in the range of from 1 to 5,
m is in the range of from 1 to 10,
p is in the range of from 0 to 5,
where in the alternative, if R and R? both represent a group OR1, both R1 may be linked to each other and together represent a divalent group —(C(R2)2)q— with q being 2, 3 or 4 and R2 being identical or different and having the above defined meanings, or
SR5, SOR5, SO2R5 wherein R5 represents alkyl, cycloalkyl, alkenyl, alkynyl, aryl, or heteroaryl, or
N(R6R7), P(R6R7) wherein R6 and R7 are identical or different and shall mean alkyl, cycloalkyl, alkenyl, alkynyl, aryl, heteroaryl, —C(?O)(R2), or
where in the alternative R6 and R7 may form together with such N or P atom to which they both are linked at the same time a saturated, unsaturated or aromatic cyclic structure with 4 to 7 carbon atoms in the cyclic structure wherein one, two or three of said carbon atoms can be replaced by a moiety selected from oxygen, sulfur, nitrogen, N—R8 or P—R8 wherein R8 shall mean alkyl, cycloalkyl, alkenyl, alkynyl, aryl, or heteroaryl; or P (?O)(OR9)2 in which R9 are identical or different and shall mean alkyl, cycloalkyl, alkenyl, alkynyl, aryl, heteroaryl,
however, under the proviso that R and R? must not both represent hydrogen in formula (1) at the same time.
US Pat. No. 10,508,159

METHOD FOR PREPARING DIENE-BASED RUBBER LATEX AND ACRYLONITRILE-BUTADIENE-STYRENE GRAFT COPOLYMER COMPRISING THE SAME

LG CHEM, LTD., Seoul (KR...

1. A method for preparing diene-based rubber latex comprising:an initial step of an entire polymerization reaction comprising adding a conjugated diene-based monomer 60 parts by weight to 75 parts by weight, a first emulsifier 1 part by weight to 3 parts by weight, a polymerization initiator 0.2 part by weight to 0.4 part by weight, an electrolyte 0.2 part by weight to 3 parts by weight, a molecular weight control agent 0.1 part by weight to 0.5 part by weight and ion exchanged water 65 parts by weight to 100 parts by weight into a reactor and then polymerizing thereof;
a step of adding the conjugated diene-based monomer 10 parts by weight to 20 parts by weight and a second emulsifier 0.1 part by weight to 1.0 part by weight simultaneously at the time point that a polymerization conversion rate of the entire polymerization reaction is 30% to 40% and then polymerizing thereof;
a step of adding a residual amount of a conjugated diene-based monomer and optionally a third emulsifier 0 part by weight to 1 part by weight simultaneously or continuously at the time point that the polymerization conversion rate of the entire polymerization reaction is 60% to 70% and then polymerizing thereof;
a step of completing polymerization by adding a polymerization inhibitor at the time point that the polymerization conversion rate of the entire polymerization reaction is 92% or higher,
which further comprises a step of additionally adding a cross-linking agent 0.05 part by weight to 0.3 part by weight at the time point that the polymerization conversion rate of the entire polymerization reaction is 0% to 50%; and
which further comprises a step of adding a fourth emulsifier having critical micelle concentration (CMC) of 150 mg/L or less 0.01 part by weight to 0.5 part by weight at the time point that the polymerization conversion rate of the entire polymerization reaction is 50% to 85%.
US Pat. No. 10,508,160

MODIFIED POLYVINYL ALCOHOL AND WATER-SOLUBLE FILM

KURARAY CO., LTD., Kuras...

1. A modified polyvinyl alcohol produced by a method comprising saponification using a saponification starting solution comprising more than 1.0 mass % and less than 2.0 mass % of water, comprising 0.05 to 10 mol % of a monomer unit having two carboxyl groups, wherein in 1H-NMR spectroscopy of the modified polyvinyl alcohol, an integral (X) from 6.8 to 7.2 ppm and an integral (Y) from 5.3 to 5.5 ppm satisfy the following expression:0.60?X/(X+Y)<1.0.
US Pat. No. 10,508,164

LOW DENSITY POLYETHYLENE COPOLYMER HAVING EXCELLENT FILM PROCESSABILITY AND TRANSPARENCY

LG Chem, Ltd., (KR)

1. A low density polyethylene copolymer which satisfies the following conditions:a melt index (MI) of 0.5 to 1.5 g/10 min as measured according to ASTM D1238 (2.16 kg, 190° C.),
a density 0.910 to 0.930 g/cm3 as measured according to ASTM D792,
a weight average molecular weight of 91,000 to 150,000, and
a melt strength (MS) of 70 to 100 mN,
wherein the low density polyethylene copolymer has ?0 (zero shear viscosity) of 140,000 P (poise) or more, and ?500 (viscosity measured at 500 rad/s) of 7,000 P (Poise) or less.
US Pat. No. 10,510,471

COMPOSITION FOR BONDED MAGNETS, BONDED MAGNET AND INTEGRALLY MOLDED COMPONENT

SUMITOMO METAL MINING CO....

1. A composition for bonded magnets, comprising 88 mass % or more and 91 mass % or less of a samarium-iron-nitrogen magnet powder having an average particle diameter of 1.8 ?m or more and 2.8 ?m or less,0.5 mass % or more and 2.5 mass % or less of a polyamide elastomer having a tensile elongation at break of 400% or more and a bending modulus of elasticity of 100 MPa or more,
0.5 mass % or more and 2.0 mass % or less of carbon fibers having a fiber diameter of 10 ?m or more and 12 ?m or less,
and 0.3 mass % or more and 1.0 mass % or less of a carboxylic acid ester,
wherein the remainder is a polyamide resin comprising polyamide 12 having a weight average molecular weight Mw of 4500 or more and 7500 or less as determined by molecular weight distribution measurement.
US Pat. No. 10,508,169

CURABLE RESIN AND PRODUCING PROCESS THEREFOR

NIPPON SHOKUBAI CO., LTD....

1. A curable resin obtained by reacting a polybasic anhydride with a reaction product of an epoxy resin with a phenol compound having an alcoholic hydroxyl group and an unsaturated monobasic acid, whereina cresol novolac epoxy resin having a softening point of 94° C. or higher and 103° C. or lower is used as the epoxy resin,
wherein a hydroxyalkyl phenol or a hydroxyalkyl cresol is used as the phenol compound,
wherein an alkenyl carboxylic acid is used as the unsaturated monobasic acid,
wherein a dibasic anhydride is used as the polybasic anhydride,
wherein the curable resin has a double bond equivalent of 480 g/eq. or more and 620 g/eq. or less, and
wherein the curable resin has an acid value of 30 mgKOH/g or more and 120 mgKOH/g or less.
US Pat. No. 10,508,171

METHOD FOR PRODUCING PERFLUOROPOLYETHER ACYL FLUORIDE

DAIKIN INDUSTRIES, LTD., ...

1. A process for producing a perfluoropolyether acyl fluoride which comprises reducing a peroxyperfluoropolyether with a formyl group-containing compound in the presence of a transition metal catalyst, wherein the formyl group-containing compound is formic acid or formic acid derivatives.
US Pat. No. 10,507,404

METHOD FOR REMOVING CONTAMINANTS FROM CANNABINOID DISTILLATES

Gary Tucker, Hayfork, CA...

1. A method for removing contaminants from cannabinoid distillates and producing a terpene-enhanced cannabinoid concentrate consisting essentially of:extracting terpene oil from cannabis to yield a residual cannabis and said terpene oil;
wherein said extracting said terpene oil from said cannabis to yield said residual cannabis and said terpene oil consists essentially of
pressurizing carbon dioxide to a pressure between 1000 psi and 1300 psi to form a supercritical carbon dioxide fluid;
exposing said cannabis to said supercritical carbon dioxide fluid at a temperature between 80° F. and 110° F. for an elapsed time between 15 minutes and 6 hours to obtain a carbon dioxide extraction solution consisting essentially of said terpene oil and residual cannabis;
obtaining cannabis oil from said residual cannabis;
distilling said cannabis oil to obtain cannabinoid distillates;
separating said cannabinoid distillates into purified cannabinoid distillates and residual contaminants separately;
wherein said separating said cannabinoid distillates into purified cannabinoid distillates and residual contaminants separately consists essentially of
mixing said cannabinoid distillates with at least a contaminant attractant consisting essentially of a hydrophilic compound to yield a cannabinoid contaminant attractant water solution consisting essentially of:
adding said contaminant attractant to said cannabinoid distillates at a ratio between 2:1 and 4:1 of said contaminant attractant by volume in mL to cannabinoid distillates by mass in grams, to yield a cannabinoid contaminant attractant solution;
heating said cannabinoid contaminant attractant solution to a temperature between 40° C. and 80° C. to yield a dissolved cannabinoid contaminant attractant solution;
adding distilled water to said dissolved cannabinoid contaminant attractant solution at a ratio between 1:4 and 1:10 of distilled water by volume in mL to cannabinoid distillates by mass in grams, to yield said cannabinoid contaminant attractant water solution; and,
heating said cannabinoid contaminant attractant water solution to a temperature between 40° C. and 60° C.
separating said cannabinoid contaminant attractant water solution into a purified cannabinoid contaminant attractant water solution and said residual contaminants separately; and,
removing said contaminant attractant and said water from said purified cannabinoid contaminant water solution to yield said purified cannabinoid distillates; and,
blending said purified cannabinoid distillates with said terpene oil to obtain a terpene oil enhanced cannabinoid concentrate.
US Pat. No. 10,508,172

BINDER

Knauf Insulation, Inc., ...

1. A binder composition comprising a polymeric product of at least one carbohydrate component, at least one amine component comprising a polyethyleneimine, and at least one additional crosslinker comprising hexamethylenediamine (HMDA), wherein the ratio of carbohydrate:polyethyleneimine:HMDA comprises a range of 78:2:20 to 74:7:19.
US Pat. No. 10,508,173

COMPOSITION FOR OPTICAL MATERIAL AND OPTICAL MATERIAL USING THE SAME

MITSUBISHI GAS CHEMICAL C...

1. A composition for optical materials containinga ring compound (a) that is at least one substance selected from the group consisting of dithiirane, 1,2-dithietane, 1,3-dithietane, trithietane, 1,2,3-trithiolane, 1,2,4-trithiolane, tetrathiolane, 1,2,3-trithiane, 1,2,4-trithiane, 1,2,3,4-tetrathiane, 1,2,4,5-tetrathiane, 1,2,3,4-tetrathiepane, 1,2,3,5-tetrathiepane, 1,2,4,5-tetrathiepane, 1,2,4,6-tetrathiepane, 1,2,3,4,5-pentathiepane, 1,2,3,4,6-pentathiepane, 1,2,3,5,6-pentathiepane, hexathiepane, diselecyclobutane, triselecyclobutane, triselecyclopentane, tetraselecyclopentane, diselecyclohexane, tetraselecyclohexane, pentaselecyclohexane, tetraselecycloheptane, pentaselecycloheptane, hexaselecycloheptane, ditellurocyclobutane, tritellurocyclobutane, tritellurocyclopentane, tetratellurocyclopentane, tetratellurocyclohexane, pentatellurocyclohexane, tetratellurocycloheptane, pentatellurocycloheptane, and hexatellurocycloheptane,
an episulfide compound (b),
sulfur (c), and
a thiol compound (d) that is at least one substance selected from the group consisting of methanedithiol, 1,2-ethanedithiol, (sulfanylmethyldisulfanyl)methanethiol, bis(2-mercaptoethyl) sulfide, 2,5-bis(mercaptomethyl)-1,4-dithiane, 1,2-bis(2-mercaptoethylthio)-3-mercaptopropane, 4,8-dimercaptomethyl-1,11-dimercapto-3,6,9-trithiaundecane, 4,7-dimercaptomethyl-1,11-dimercapto-3,6,9-trithiaundecane, 5,7-dimercaptomethyl-1,11-dimercapto-3,6,9-trithiaundecane, 1,2,6,7-tetramercapto-4-thiaheptane, tetramercaptopentaerythritol, 1,3-bis(mercaptomethyl)benzene, and thiiranemethanethiol,
wherein in the composition for optical materials, the content of the ring compound (a) is 5 to 70% by mass, the content of the episulfide compound (b) is 20 to 90% by mass, the content of the sulfur (c) is 1 to 39% by mass, and the thiol compound (d) is 0.1 to 15 parts by mass relative to 100 parts by mass of the total amount of the ring compound (a), the episulfide compound (b), and the sulfur (c).
US Pat. No. 10,508,174

SILICON-CONTAINING COATING AGENT FOR REVERSING PLANARIZATION PATTERN

NISSAN CHEMICAL INDUSTRIE...

1. A composition to be applied over a resist pattern, the composition comprising a modified polysiloxane in which some of silanol groups of a polysiloxane containing a hydrolysis condensate of a hydrolyzable silane are capped, and a solvent, wherein a ratio of silanol groups to all Si atoms contained in the modified polysiloxane is 40 mol % or less.
US Pat. No. 10,508,175

COMPOSITION AND POLYAMIDEIMIDE COMPOSITE AND POLYAMIDEIMIDE FILM AND ELECTRONIC DEVICE

SAMSUNG ELECTRONICS CO., ...

1. A composition comprising:a polyamideimide precursor modified with an alkoxysilane group and
an oligosilica compound,
wherein the polyamideimide precursor is polyamide-co-poly(amic acid), and
wherein the oligosilica compound is a condensation product of an organosilane diol and an alkoxysilane compound.
US Pat. No. 10,508,176

FOAMABLE RESIN COMPOSITION FOR FOAM SHEET, FOAM SHEET, PROCESS FOR PREPARING PARTICULATE POLYLACTIC ACID AND PROCESS FOR PREPARING FOAM SHEET

LG HAUSYS, LTD., Seoul (...

1. A process for preparing a particulate polylactic acid resin comprising:introducing a polylactic acid resin into an extruder;
forming a molten polylactic acid spray solution by transferring the polylactic acid resin to an spray nozzle and heating the polylactic acid resin in the spray nozzle; and
spraying the molten polylactic acid spray solution by a melt spray method and simultaneously cooling the molten polylactic acid spray solution to obtain a particulate polylactic acid,
wherein a voltage ranging from 2,000 V to 50,000 V is applied to the spray nozzle to carry out a melt electrostatic spray deposition.
US Pat. No. 10,508,179

THERMOPLASTIC VULCANIZATE PREPARED WITH OIL-EXTENDED, BIMODAL METALLOCENE-SYNTHESIZED EPDM

ExxonMobil Chemical Paten...

1. A process for producing a thermoplastic vulcanizate, the process comprising:(i) charging a reactor with an oil-extended olefinic copolymer rubber, where the rubber is synthesized by a single-site catalyst, characterized by a multi-modal molecular weight distribution, and includes greater than 10 parts by weight extender oil per 100 parts by weight rubber;
(ii) charging the reactor, contemporaneously or sequentially with respect to the rubber, with a thermoplastic resin, a process oil, and a cure system to provide a pre-vulcanized mixture; and
(iii) mixing the rubber, thermoplastic resin, oil, and cure system at a temperature above the melt temperature of the thermoplastic resin to thereby cause dynamic vulcanization of the rubber and produce the thermoplastic vulcanizate.
US Pat. No. 10,508,435

BUILDING ASSEMBLY INCLUDING A WEATHER RESISTANT BARRIER, A SHEET FOR USE AS A WEATHER RESISTANT BARRIER, A LIQUID COATING COMPOSITION AND METHODS OF MAKING THE FOREGOING

CERTAINTEED CORPORATION, ...

1. A building assembly comprising a building substrate and a weather resistive barrier (WRB), the WRB having a water vapor permeability that decreases with increasing temperature in a temperature range from 5° C. to 60° C. at 25% relative humidity (RH).
US Pat. No. 10,508,436

THERMALLY INSULATING COMPOSITION FOR ORGANIC MONOLITHIC GEL, USE THEREOF AND PROCESS FOR PREPARING SAME

Hutchinson, Paris (FR)

1. A gelled carbon-based composition for forming an organic polymeric monolithic aerogel capable of forming a porous carbon monolith by pyrolysis, the composition being based on a resin derived from polyhydroxybenzene(s) R and formaldehyde(s) F,wherein said gelled composition comprises at least one water-soluble cationic polyelectrolyte P, said gelled composition comprising the product of a polymerization reaction, in an aqueous solvent W, only of said polyhydroxybenzene(s) R and said formaldehyde(s) F, in the presence of said at least one cationic polyelectrolyte P dissolved in said solvent and of a catalyst,wherein said gelled composition has:a pore volume of between 0.1 cm3/g and 3 cm3/g,
a density of between 0.04 and 0.06,
a thermal conductivity from 10 to 35 mW·m?1·K?1, measured at 22° C. with a Neotim conductivity meter according to the hot wire technique, and
at least one of a compression modulus of 800 MPa and a breaking strength of 25 MPa, measured in three-point compression and in tension with a MTS tensile/compression testing machine according to standard ASTM C165-07,
and
wherein the product of the polymerization reaction comprises said at least one cationic polyelectrolyte P in a mass fraction of between 0.2% and 2%.
US Pat. No. 10,508,186

CHEMICAL RECYCLING OF POLYETHYLENE TEREPHTHALATE BY MICROWAVE IRRADIATION

The University of North C...

1. A method of making bis(2-hydroxyethyl) terephthalate (BHET) from polyethylene terephthalate (PET), comprising:(a) combining PET with ethylene glycol and a catalyst system to produce a heterogeneous reaction mixture, wherein the catalytic system comprises a catalyst and a microwave absorber, with the catalyst being selected from the group consisting of: zinc acetate, zinc chloride, manganese acetate, 1, 5, 7-triazabicyclo [4.4. 0] dec-5-ene (TBD), 1, 8-diazabicyclo [5. 4. 0]undec-7-ene (DBU), magnesium acetate, 4-dimethylaminopyridine (DMAP), and combinations thereof, and with the microwave absorber being selected from the group consisting of a sodium salt, lithium salt, potassium salt, calcium salt, a magnesium salt, or combination thereof; and then
(b) heating by microwave irradiation the reaction mixture to produce a reaction product comprising BHET.
US Pat. No. 10,508,187

INORGANIC MATERIAL COMPOSITE

Tundra Composites, LLC, ...

1. A method of making an inorganic material particulate and polymer composite comprising:(a) coating about 40 to 90 vol. % of an inorganic material particulate having a particle size greater than about 5 microns with an interfacial modifier, the percentage based on the composite, to form an interfacial modifier coated particle;
(b) combining the coated particle with a polymer phase under melt processing conditions to make the composite, and;
(c) forming a pellet by melt processing the composite.
US Pat. No. 10,511,003

SEPARATOR FOR BATTERIES AND METHOD FOR MANUFACTURING THE SAME

AZA HOLDING PTE. LTD., S...

1. A method for preparing a separator, which is permeable to hydroxide ions, for use in an electrically rechargeable electrochemical cell with alkaline electrolyte between a zinc electrode and a counter electrode, wherein: (a) said separator is constituted by a porous or fibrous material defining cavities or pores, and at least one Dendrite Stopping Substance or DSS, said DSS being a metal-containing compound, said metal selected from the group consisting of Pt, Pd, Ni, Fe and Mn, and, (b) said DSS being in a form of particles, said method comprising:a first step of soaking a porous or fibrous material defining cavities or pores with a first solution comprising at least one DSS precursor, said DSS being a metal-containing compound, said metal being selected from the group consisting of Pt, Pd, Ni, Fe and Mn, and
a second step of impregnating the resulting soaked material with a second solution, wherein said second solution allows the precipitation of the at least one DSS precursor in form of the DSS particle, wherein the material resulting from the second step contains the at least one DSS particle within its cavities or pores, and wherein the material resulting from the second step forms the separator.
US Pat. No. 10,508,188

ANTIMICROBIAL AND ANTIFUNGAL POLYMER FIBERS, FABRICS, AND METHODS OF MANUFACTURE THEREOF

PurThread Technologies, I...

1. A polymer composition comprising:(a) a polymer;
(b) about 1 to about 26 wt. % of a silver salt having the formula AgaXbYcZd;
(c) about 0.1 to about 2.6 wt. % of a copper salt having the formula CuaXbYcZd; and
(d) one or more additives;
Ag is Ag(I) or Ag(II), and a is 1 to 4;
each X is sulfur, and b is independently 1 to 4;
each Y is oxygen, and c is independently 2 to 8;
each Z is independently H; C1-C14 alkyl; C3-C8 cycloalkyl; C1-C8 alkyl substituted by C3-C6 cycloalkyl; C1-C8 alkyl optionally substituted by C6-C10 aryl; C6-C10 aryl; C6-C10 aryl substituted by C1-C14 alkyl, C3-C8 cycloalkyl, C1-C8 alkyl substituted by C3-C6 cycloalkyl, or halogen;
d is 0 or 1;
wherein each of the silver salt and the copper salt is mixed with the polymer.
US Pat. No. 10,508,191

FLAME-RETARDANT POLYCARBONATE RESIN COMPOSITION, SHEET AND FILM EACH USING SAME, AND METHOD FOR PRODUCING SAID SHEET OR FILM

MITSUBUSHI GAS CHEMICAL C...

1. A polycarbonate resin composition, which contains 18 to 75% by mass of a polycarbonate resin (A) having a viscosity average molecular weight of 35,000 to 60,000, 5 to 30% by mass of a phosphorus-based flame retardant (B), 18 to 50% by mass of a fibrous or plate-like inorganic filler (C) and 0.1 to 2% by mass of a fluoropolymer (D), which has a melt volume rate of 2.0 to 6.0 cm3/10 min under 300° C. and 1.2 kg.
US Pat. No. 10,510,495

ELECTROCHEMICAL CAPACITOR

OSAKA SODA CO., LTD., Os...

1. An electrochemical capacitor comprising:a negative electrode,
a gel electrolyte composition which comprises an electrolyte salt and a gel of a crosslinked polyether copolymer having ethyleneoxide units, and
a positive electrode,
wherein a photoreaction initiator which crosslinks the polyether copolymer is an alkyl phenone photoreaction initiator, and
wherein a thickness of a gel electrolyte composition layer comprising the electrolyte salt and the polyether copolymer having ethyleneoxide units, which is prepared by crosslinking and gelling, is 5 to 20 micrometers.
US Pat. No. 10,507,170

OPEN POROUS ORGANIC-INORGANIC COMPOSITE POWDER, METHOD FOR PREPARING SAME, AND COSMETIC COMPOSITION CONTAINING SAME

COSMAX, INC., Gyeonggi-d...

1. A method for preparing porous organic/inorganic composite powder, which comprises the steps of:(a) attaching polyphenol to porous polymethyl methacrylate (PMMA) microspheres;
(b) attaching inorganic oxide nanoparticles to the resultant product of step (a); and
(c) subjecting the resultant product of step (b) to attachment of polyphenol and attachment of inorganic oxide nanoparticles repeatedly so that inorganic oxide nanoparticles may be attached in a multi-layer form.
US Pat. No. 10,508,194

FLAME-RETARDANT POLYOLEFIN RESIN COMPOSITION

ADEKA CORPORATION, Tokyo...

1. A flame-retardant polyolefin resin composition comprising 100 parts by mass of a polypropylene resin, 10 to 60 parts by mass of component (A), 15 to 90 parts by mass of component (B), and 10 to 140 parts by mass of component (C):component (A): melamine pyrophosphate;
component (B): piperazine pyrophosphate: and
component (C): glass fiber;
said composition being free of fluorine-containing anti-drip agents.
US Pat. No. 10,507,171

PEROXIDE-STABLE ORAL CARE COMPOSITIONS

Colgate-Palmolive Company...

1. An oral care composition comprising (i) a peroxide whitening agent comprising a whitening complex of crosslinked polyvinylpyrrolidone complexed with hydrogen peroxide, (ii) sodium acid pyrophosphate (Na2H2P2O7) in an amount of from 0.1 wt % to 3 wt % based on the weight of the composition, and (iii) less than 2 wt % water based on the weight of the composition; and (iii) an ethylene oxide, propylene oxide block co-polymer of average molecular weight greater than 5000 Da, being substantially free of an ethylene oxide, propylene oxide block co-polymer of average molecular weight less than 5000 Da in an amount of from 5 wt % to 12 wt % based on the weight of the composition; and (iv) from 1 to 2 wt % tetrasodium pyrophosphate based on the weight of the composition.
US Pat. No. 10,507,172

HYALURONIC ACID FORMULATION CONTAINING PYRUVATE

ALLERGAN INDUSTRIE, S.A.S...

1. A composition comprising: a hyaluronic acid or a salt thereof and pyruvic acid or a salt thereof, wherein the hyaluronic acid or its salt is crosslinked, the composition is suitable for use as a dermal filler, and the composition is a gel that is stable to heat sterilization, wherein the gel has a ?F of ?2N??F?2N after heat sterilization and a ? Tan ? 1 Hz?0.1 after heat sterilization.
US Pat. No. 10,508,197

THERMOPLASTIC VULCANIZATE COMPOSITIONS

ExxonMobil Chemical Paten...

1. A method for preparing a thermoplastic vulcanizate, the method comprising:dynamically vulcanizing at least a portion of an elastomer component in the presence of a thermoplastic resin and a curing agent so as to form a thermoplastic vulcanizate wherein the elastomer component is at least partially vulcanized and is dispersed in a continuous phase comprising the thermoplastic resin; and
introducing a carbon black masterbatch into the thermoplastic vulcanizate, wherein the carbon black masterbatch comprises carbon black particulates dispersed in a carrier resin comprising a propylene-?-olefin copolymer, the propylene-?-olefin copolymer comprising about 50 wt % to about 99 wt % propylene-derived units and about 1 wt % to about 35 wt % comonomer units derived from one of ethylene and a C4-C10 alpha-olefin, and having a heat of fusion of about 75 J/g or less.
US Pat. No. 10,508,198

ANTI-AGGLOMERANTS FOR POLYISOBUTYLENE PRODUCTION

BASF South East Asia Pte....

1. A composition comprising 98.5 wt.-% or more of polyisobutylene and having an ash content measured according to ASTM D5667 of 0.2 wt.-% or less.
US Pat. No. 10,507,175

CURLING MASCARA COMPOSITIONS

ELC MANAGEMENT LLC, Melv...

1. A single phase, aqueous mascara composition for curling eyelashes comprising, by total weight of the composition:one or more ammonium styrene/acrylates copolymers totaling 10% to 30%, wherein the one or more ammonium styrene/acrylates copolymers comprising exactly two ammonium styrene/acrylates copolymers whose glass transition temperatures are in a ratio of 2:1 to 3:1, and whose relative concentrations are 1:1 to 4:1;
0.5% to 2.8% of acrylates/VA copolymer;
up to 10% of pigments; and
at least 50% of water,
wherein the composition having no more than 3% of surfactants or emulsifiers.
US Pat. No. 10,508,199

PHOTOCURABLE EPOXY RESIN SYSTEMS

1. A photocurable epoxy resin composition comprising:(a) 30 to 90 wt % of at least one aromatic epoxy resin;
(b) 2 to 30 wt % of at least one core-shell rubber as toughener;
(c) 1 to 20 wt % of at least one flexibilizer comprising reactive functional groups selected from epoxy groups, carboxylate groups, amino groups and/or hydroxyl groups;
(d) 1 to 4 wt % of at least one cationic photoinitiator;
(e) a co-toughener in an amount of 0.1-10 wt %; and/or
(f) a reactive diluent in an amount of 0.1-10 wt %; and/or
(g) an adhesion promoter selected from chelate-modified epoxy resins and epoxy-modified silanes in an amount of 0.1-3 wt %, characterized in that the at least one flexibilizer comprises epoxy groups.
US Pat. No. 10,507,177

ANTI-AGING HAIR TREATMENT

1. An anti-aging treatment shampoo comprising:a. Acetyl Cysteine;
b. Alcohol;
c. Inositol;
d. Lactose;
e. Citric acid;
f. Milk Protein (Lactis Proteinum);
g. Panthenyl Ethyl Ether;
h. Serenoa;
i. Sodium Citrate;
j. Glycine soja (soybean) Germ Extract;
k. Biotinoyl Tripeptide;
l. Oleanolic Acid;
m. Butylene Glycol;
n. PEG-40 Hydrogenated Castor Oil;
o. PPG-26-Buteth-26;
p. Arginine
q. Lactic Acid
r. Propanediol
s. Scutellaria baicalensis Root Extract;
t. Acetyl Methione
u. Triticum vulgare (wheat) Germ Extract;
v. Beeswax;
w. Behenyl Alcohol
x. Butyrospermum parkii (Shea Butter) Extract
y. Ethylhexylglycerin
z. Hydroxyethyl Behenamidopropyl Dimonium Chloride
aa. Phenoxyethanol
bb. Pyrus malus Extract;
cc. Caprylhydroxamic Acid
dd. Caprylyl Glycol
ee. Glycerin;
ff. Cetyl Betaine;
gg. Citrullus colocynthis Fruit Extract
hh. Pisum sativum (Pea) Peptide;
ii. Cocamidopropyl Betaine
jj. Sodium Cocoyl Isethionate
kk. Sodium;
ll. Cuscuta reflexa (Giant Dodder) Extract;
mm. Eclipta alba Extract;
nn. Hydrolyzed Quinoa;
oo. Hydrolyzed Rice Protein;
pp. Serrulata Fruit Extract;
qq. Polyquatemium 7;
rr. Purified Water;
ss. Apigenin;
tt. Sodium Lauroyl Methyl Isethionate by weight;
uu. Stearamidopropyl Dimethylamine;
vv. Leuconostoc/Radish Root Ferment Filtrate;
ww. Cannabidiol (CBD);
xx. Calendula officinalis Flower Extract;
yy. Citrus aurantium bergamia (Bergamot) Fruit Extract;
zz. Citrus grandis (Grapefruit) Fruit Extract;
aaa. Citrus (Limon) Peel Extract
bbb. Juniperus Virginia Wood Extract;
ccc. Santalum album (Sandalwood) Wood Extract; and
ddd. Vanilla planifolia Fruit Extract.
US Pat. No. 10,508,201

METHODS FOR MANUFACTURING AZOIC PIGMENTS

Ferro Corporation, Mayfi...

1. A method for manufacturing an azoic pigment, the method comprising the steps ofi) obtaining a slurry of an azoic pigment, the slurry including residual primary aromatic amine (PAA);
ii) derivatization of the residual PAA in the slurry;
iii) encapsulation of the slurry;
iv) final processing of the slurry, the final processing including forming PAA migration free azoic pigment;
wherein the derivatization and encapsulation synergistically reduce PAA content thereby inhibiting migration of PAA from the pigment to a surface in contact.
US Pat. No. 10,507,178

METHOD FOR TREATING INTERVERTEBRAL DISC DEGENERATION

Research Foundation of th...

1. A method for providing therapeutic benefit to a patient experiencing soft tissue damage between a first bone and a second bone, the method comprising:injecting a composition of matter between the first bone and the second bone of a patient, the composition of matter comprising methacrylated carboxymethylcellulose (CMC), methacrylated methylcellulose (MC), and a polymerization initiator, wherein the patient has a body temperature of at least 33° C.;
permitting the composition of matter to undergo thermal polymerization at the body temperature of the patient, thereby forming a hydrogel between the first bone and the second bone;
wherein the methacrylated methylcellulose (MC) is a mix of a first methacrylated methylcellulose with a first molecular weight below about 20 kDa and a second methacrylated methylcellulose with a second molecular weight above about 30 kDa, the mix being at least 3% (w/v) concentration and less than 8% (w/v) concentration, the first methacrylated methylcellulose and the second methacrylated methylcellulose being in about a 1:1 (w/w) ratio;
wherein the methacrylated carboxymethylcellulose (CMC) has a molecular weight between about 80 kDa and about 100 kDa and is at least 3% (w/v) and less than 8% (w/v) concentration;
wherein the methacrylated methylcellulose (MC) and the methacrylated carboxymethylcellulose (CMC) are present in a 1:1 (w/w) ratio.
US Pat. No. 10,507,179

FORMULATIONS OF LEVOSIMENDAN FOR INTRAVENOUS ADMINISTRATION AS INFUSION OR INJECTION AND OF INFUSION CONCENTRATE

CARINOPHARM GMBH, Elze (...

1. A pharmaceutical composition, comprising Levosimendan as active ingredient, and sulfo-butyl-ether beta-cyclodextrin as a solubilizer, with the proviso that the use of co-solvents comprised of ethanol, propyleneglycol, polyethyleneglycol, poloxamers or polyvinylpyrrolidon is excluded.
US Pat. No. 10,508,204

SELF-HEALING COATING

The Board of Trustees of ...

1. An autonomic self-healing material comprisinga plurality of microcapsules having a first outer shell;
a photopolymer composition encapsulated within he first shell of the microcapsules; and
a Pickering emulsion of photo-protecting solid particles lining the inside wall of the first outer shell, wherein the first outer shell and Pickering emulsion of photo-protecting solid particles form a photo-protecting outer shell that absorbs or reflects electromagnetic radiation to effectively prevent curing of the encapsulated photopolymer composition;where the self-healing process is autonomically initiated when a region of the material is sufficiently damaged to induce rupturing of one or more microcapsules, which release the photopolymer composition in and/or around the damaged region, and the released photopolymer composition is exposed to electromagnetic radiation.
US Pat. No. 10,511,021

NON-AQUEOUS ELECTROLYTE SECONDARY BATTERY

SANYO Electric Co., Ltd.,...

1. A nonaqueous electrolyte secondary battery comprising a positive electrode, a negative electrode, and a nonaqueous electrolyte,wherein the positive electrode contains a lithium transition metal oxide, having a layered structure, containing at least Ni and also contains a tungsten compound and/or a molybdenum compound;
the percentage of Ni is greater than 90.00 mole percent with respect to the sum of the molar amounts of metal elements, excluding lithium, in the lithium transition metal oxide;
the amount of the tungsten compound and/or the molybdenum compound is 0.1 mole percent to 1.5 mole percent with respect to the sum of the molar amounts of the metal elements, excluding lithium, in the lithium transition metal oxide in terms of tungsten element and/or molybdenum element; and
wherein the lithium transition metal oxide is represented by the formula LiaNixM1-xO2 (where 0.95?a?1.20, 0.94?x, and M is at least one element selected from Co, Mn, and Al),
wherein the nonaqueous electrolyte contains a lithium salt containing a P—O bond in its molecule and a nitrile compound.
US Pat. No. 10,507,186

METHODS AND COMPOSITIONS PARTICULARLY FOR TREATMENT OF ATTENTION DEFICIT DISORDER

Purdue Pharma L.P., Stam...

when tested according to the USP paddle method, 100 rpm, at 37° C.; (i) starting with 900 ml simulated gastric fluid for 2 hours, (ii) followed by 900 ml phosphate buffer pH 6.0 for 4 hours, and (iii) for the 7th hour onwards, 900 mL of phosphate buffer pH 7.4; USP <711> Acceptance Table 2; andwherein the plurality of coated beads provides, in a fasted state, an in vivo methylphenidate Tmax0-4 of about 1.63 hours and a methylphenidate Tmax8-16 of about 12.5 hours.
US Pat. No. 10,507,187

REGENERATIVE TISSUE GRAFTS AND METHODS OF MAKING SAME

THE HENRY M. JACKSON FOUN...

1. A method of obtaining human mesenchymal progenitor cells from debrided human muscle tissue, comprising:obtaining a sample of debrided human muscle tissue that has been traumatized by mechanical stress comprising extensive mincing until the sample could pass through the tip of a 25-mL serological pipette to induce the formation of human mesenchymal progenitor cells that are positive for CD105 and CD73, wherein the CD105/CD73 ratio is greater than a CD105/CD73 ratio of bone-marrow derived mesenchymal stem cells; and
isolating said human mesenchymal progenitor cells from the sample, wherein the isolated human mesenchymal progenitor cells are positive for CD105 and CD73, wherein the CD105/CD73 ratio is greater than a CD105/CD73 ratio of human bone-marrow derived mesenchymal stem cells.
US Pat. No. 10,507,188

PARTICLES CONTAINING AN OPIOID RECEPTOR ANTAGONIST AND METHODS OF USE

The University of Chicago...

1. An enterically-coated particle comprising at least one opioid receptor antagonist, at least one hydrophilic additive that is negatively charged at acidic and neutral pH that is pentasodium tripolyphosphate (TPP), and at least one hydrophilic additive that is positively charged at acidic and neutral pH that is chitosan;wherein the enteric coating comprises a methacrylic acid-methyl methacrylate copolymer.
US Pat. No. 10,508,213

AQUEOUS DISPERSION OF KETO-FUNCTIONALIZED POLYMER PARTICLES AND POLYMER BEADS

Rohm and Haas Company, P...

1. A composition comprisinga) an aqueous dispersion of
1) polymer particles having an average particle size in the range of from 75 nm to 350 nm, and
2) crosslinked polymer beads having an average particle size in the range of from 1 ?m to 30 ?m;
wherein the polymer particles comprise from 0.1 to 12 weight percent structural units of a monomer containing keto functionality, based on the weight of the polymer particles; and the crosslinked polymer beads comprise 0.05 to 12 weight percent structural units of a monomer containing keto functionality based on the weight of the crosslinked polymer beads; and
wherein the weight to weight ratio of polymer particles to crosslinked polymer beads is in the range of 1:10 to 10:1; and
b) from 0.1 to 10 weight percent of a dihydrazide or a polyamine crosslinking agent, based on the weight of the paint composition.
US Pat. No. 10,509,237

METHOD AND APPARATUS FOR MEASURING ADD POWER OF A CONTACT LENS

CooperVision Internationa...

1. A method of measuring the add power of a contact lens having a central region and an annular region surrounding the central region, the central region having a first optical power and the annular region having a second optical power, the method including the steps:(a) measuring the wavefront aberration of the contact lens;
(b) fitting a polynomial to the measured wavefront aberration, wherein terms of the polynomial correspond to types of aberration comprising defocus and astigmatism and residual aberrations; and
(c) calculating the add power as a defocus corresponding to the residual aberrations,
wherein calculating the add power includes the steps of discarding from the polynomial the terms of the polynomial that correspond to defocus and astigmatism to obtain a modified polynomial that contains only terms of higher aberration order than defocus and astigmatism and calculating the residual aberrations using the modified polynomial; and
the add power is calculated as the spherical equivalent of the residual aberrations or the spherical aberration.
US Pat. No. 10,508,216

STAIN RESISTANT COATING COMPOSITIONS AND COATINGS FORMED THEREFROM

PPG Industries Ohio, Inc....

1. A coating composition comprising:a) a polyester polyol comprising a reaction product obtained from a mixture of reactants comprising:
an aliphatic diol;
a polyol comprising 3 or more hydroxyl groups; and
an aliphatic cyclic polycarboxylic acid, or an anhydride or ester thereof, that comprises greater than 10 mole % of the total carboxylic acids, or anhydrides or esters thereof, used to prepare the polyester;
b) a silicone component comprising at least one reactive functional group; and
c) a crosslinker reactive with (a) and (b),
wherein the polyester polyol has a hydroxyl value of greater than 300 mg KOH/g.
US Pat. No. 10,508,219

POLISHING COMPOSITION AND METHOD UTILIZING ABRASIVE PARTICLES TREATED WITH AN AMINOSILANE

Cabot Microelectronics Co...

1. A chemical-mechanical polishing composition for polishing a substrate comprising:(i) a liquid carrier,
(ii) an abrasive suspended in the liquid carrier, wherein the abrasive comprises colloidal silica particles having a surface which has been treated with a compound selected from the group consisting of an aminosilane compound, a phosphononiumsilane compound, and a sulfonium silane compound, wherein the particles have a percent surface coverage from about 5% to about 32%, and
(iii) about 0.0001 wt. % to about 3 wt. % of a corrosion inhibitor, wherein the polishing composition has a pH of about 1.5 to about 5.
US Pat. No. 10,508,220

SLURRY COMPOSITION AND ADDITIVES AND METHOD FOR POLISHING ORGANIC POLYMER-BASED OPHTHALMIC SUBSTRATES

Ferro Corporation, Mayfi...

1. An aqueous dispersion for polishing organic polymer-based ophthalmic substrates comprising:5% to about 40% by weight abrasive particles,
0.1-10% by weight of at least one selected from the group consisting of (a) of a polyvinyl alcohol compound, (b) a tertiary amide compound, and (c) combinations thereof,
0.25% to 4.0% by weight aluminum nitrate,
0.5% to about 5% by weight aluminum hydroxide, and deionized water.
US Pat. No. 10,507,197

PHARMACEUTICAL COMPOSITION CONTAINING SILIBININ

Tasly Pharmaceutical Grou...

1. A pharmaceutical composition comprising a mixture of three bulk drugs, wherein the mixture consists of8.75-60 parts by weight of silibinin;
15-65 parts by weight of phospholipid; and
25-200 parts by weight of Pu'er tea extract,wherein parts by weight is the weight ratio of each bulk drug in the mixture.
US Pat. No. 10,511,039

SOLID STATE HYDROGEN STORAGE DEVICE AND SOLID STATE HYDROGEN STORAGE SYSTEM

Hyundai Motor Company, S...

1. A solid-state hydrogen storage device, comprising:a storage unit configured to store a first hydrogen storage material therein;
a heat medium pipe disposed in the storage unit including a heat medium;
a separating pipe disposed in the heat medium pipe including a second hydrogen storage material, wherein the second hydrogen storage material is enclosed in the heat medium; and
a first gas supply pipe connected with a storage vessel and the separating pipe,
wherein the first gas supply pipe supplies gaseous hydrogen included in a storage vessel to the separating pipe,
wherein the second hydrogen storage material releases heat during hydrogen absorption,
wherein heat is released from the second hydrogen storage material during hydrogen absorption, and
wherein the heat released during the hydrogen absorption is supplied to the first hydrogen storage material included in the storage unit through the heat medium included in the heat medium pipe, thereby releasing hydrogen from the first hydrogen storage material.
US Pat. No. 10,508,992

METHOD AND PROBE FOR MONITORING OXYGEN STATUS IN LIVE MAMMALIAN CELLS

University College Cork, ...

1. A method of determining oxygen concentration in a live mammalian cell sample by photoluminescence quenching technique, which method employs a photoluminescent probe, the method comprising the steps of:incubating the live mammalian cell sample in a suitable growth medium with the photoluminescent probe whereby the probe self-loads sans any loading reagent into the cells of the mammalian cell sample;
detecting a photoluminescent signal of the probe from the probe-loaded cell sample; and
correlating the detected photoluminescent signal to local oxygen concentration within the cell sample,wherein the photoluminescent probe is an aqueous suspension of polymeric particles having an averagee size of 20 to 100 nm and a probe concentration of 0.1 to 100 ?g/ml, the particles comprising an amphiphilic cationic polymer matrix having a hydrophobic core and a hydrophilic positively charged surface provided by quaternary amino groups, and a hydrophobic oxygen-sensitive photoluminescent dye embedded in the hydrophobic core, and wherein the nanoparticulate probe is capable of penetrating the cell and providing a high loading efficiency, a stable photoluminescence intensity signal, and reliable lifetime-based sensing of intracellular oxygen.
US Pat. No. 10,507,203

METHYLPHENIDATE EXTENDED RELEASE CHEWABLE TABLET

TRIS PHARMA, INC, Monmou...

1. An extended release dexmethylphenidate chewable tablet, wherein said chewable tablet is a uniform solid dispersion comprising:a sustained release dexmethylphenidate component comprising a water-insoluble, water-permeable, pH-independent barrier coated, dexmethylphenidate-cation exchange resin complex in an optional polymeric matrix, wherein the barrier coating is present in an amount of about 20% w/w to about 50% w/w % based on the weight of the coated complex-optional matrix, wherein the barrier coating provides a sustained release profile to the dexmethylphenidate and is over the dexmethylphenidate-cation exchange resin complex-optional matrix, and wherein when present the polymeric matrix comprises the dexmethylphenidate-cation exchange resin complex and a water-insoluble polymer or copolymer or a water-soluble polymer or copolymer; and
at least one immediate release dexmethylphenidate component which provides a release in less than about 30 minutes as determined in an in vitro dissolution assay;
wherein about 50% w/w to about 90% w/w of the dexmethylphenidate active component is provided by the sustained release component based on the total amount of dexmethylphenidate in the tablet;
wherein said chewable tablet is capable of being divided and providing tablet portions which retain a therapeutically effective extended release profile.
US Pat. No. 10,508,227

CONTROLLED RELEASE OF SURFACTANTS FOR ENHANCED OIL RECOVERY

Saudi Arabian Oil Company...

1. A sparingly soluble sulfonate-metal salt particle comprises a metal ion salt of an alkyl aryl sulfonate, a metal ion salt of a petroleum sulfonate and a hydrophobically modified hydrophilic polymer,where the sparingly soluble sulfonate-metal salt particle has an average particle size diameter in a range of from about 50 nm to about 450 nm, and
where the sparingly soluble sulfonate-metal salt particle is sparingly soluble in water at room temperature.
US Pat. No. 10,507,204

PHARMACEUTICAL COMPOSITION COMPRISING AMORPHOUS LENALIDOMIDE

Synthon B.V., Nijmegen (...

1. A pharmaceutical composition comprising (i) an amorphous adsorbate of lenalidomide, or a pharmaceutically acceptable salt thereof, on a porous carrier and (ii) one or more pharmaceutically acceptable excipients.
US Pat. No. 10,508,230

HIGH TEMPERATURE FRACTURING FLUIDS WITH NANO-CROSSLINKERS

Saudi Arabian Oil Company...

1. A method for increasing conductivity in a hydrocarbon producing subterranean reservoir formation, the method comprising the steps of:a. identifying a hydrocarbon producing subterranean reservoir formation; and
b. introducing an effective amount of the fracturing fluid system into the hydrocarbon producing subterranean reservoir formation such that conductivity is increased within fractures,
wherein the fracturing fluid system comprises a fluid composition and a base fluid,
wherein the fluid composition comprises:
a nano-crosslinker, wherein the nano-crosslinker comprises a nanomaterial and a crosslinker, wherein the crosslinker comprises a chemical group selected from the group consisting of carbonyl, sulfhydryl, amine and imine, wherein the nano-crosslinker is produced by a method selected from the group consisting of pre-treating the nanomaterial with the crosslinker such that the crosslinker has been functionalized onto the nanomaterial, embedding the crosslinker on the nanoparticle, grafting the crosslinker onto the nanomaterial, and coating the crosslinker on the nanomaterial, and
a base polymer; and
wherein the base fluid is operable to suspend the fluid composition, the base fluid comprising water;
wherein the fluid composition and the base fluid are combined to produce the fracturing fluid system.
US Pat. No. 10,508,233

MIXED COMPOUND ORGANIC GLASS SCINTILLATORS

1. A mixed compound glass scintillator comprising:a first compound and a second compound:
the first compound is organic, has a Tg greater than 25° C., is capable of generating luminescence in the presence of ionizing radiation, and includes:
a central species selected from the group consisting of: carbon, silicon, and tin;
a luminescent organic group bonded to the central species or to an optional organic linker group;
the optional organic linker group, if present, is bonded to the central species and the luminescent organic group;
the second compound has a Tg greater than 25° C.;
the first and second compound are mixed and melted to form a glass material.
US Pat. No. 10,507,211

TREATMENT FOR HEREDITARY NEUROPATHY WITH LIABILITY TO PRESSURE PALSIES (HNPP)

Vanderbilt University, N...

1. A method of treating hereditary neuropathy with liability to pressure palsies (HNPP), comprising administering to a subject in need of treatment for HNPP a therapeutically effective amount of a PAK1 inhibitor that is PF-3758309.

US Pat. No. 10,511,994

METHODS FOR CONFIGURING BUFFER STATUS REPORT FOR NEXT-GENERATION MOBILE COMMUNICATION AND APPARATUSES THEREOF

KT CORPORATION, Gyeonggi...

1. A method for transmitting, by a terminal, a buffer status report (BSR), the method comprising:receiving allocation information for uplink resources from a base station;
determining whether a number of padding bits for data transmission using the uplink resources is i) greater than or equal to a first value and ii) less than a second value, wherein the first value is a size of Short BSR plus a subheader of the Short BSR and the second value is a size of Long BSR plus a subheader of the Long BSR;
determining whether available data for uplink transmission is present in one or more logical channel groups (LCGs) when the number of padding bits is i) greater than or equal to the first value and ii) less than the second value; and
transmitting one of Short Truncated BSR and Long Truncated BSR to the base station according to a result of comparison between the number of padding bits and the first value when available data for uplink transmission is present in the one or more LCGs,
wherein the transmitting comprises:
transmitting the Short Truncated BSR when the number of padding bits is equal to the first value; and
transmitting the Long Truncated BSR when the number of padding bits exceeds the first value.

US Pat. No. 10,511,596

MUTUAL AUTHENTICATION

KELISEC AB, Bromma (SE)

1. A system for authenticating, comprising:a first computing device, a second computing device and a server;
wherein the first computing device is configured to perform:
generating a first authentication token (AT), the first authentication token (AT) being a data structure to be used for authenticating the first computing device to the second computing device, and sending the first authentication token (AT) to the server;
wherein the server is configured to perform:
receiving and authenticating the first authentication token (AT), and
generating a second authentication token for the first computing device and sending the second authentication token (AT) to the first computing device;
wherein the first computing device is configured to perform:
receiving and authenticating the second authentication token (AT), thereby performing a mutual authentication of the first computing device and the server;
wherein the server is further configured to perform:
generating a third authentication token (AT) for the second computing device and sending the third authentication token to the first computing device;
wherein the first computing device is further configured to perform:
receiving the third authentication token (AT) and sending it to the second computing device;
wherein the second computing device is configured to perform:
receiving and authenticating the third authentication token (AT) thereby performing an authentication of the server and the first computing device;
wherein the second computing device is configured to further authenticate the server by:
generating a fourth authentication token (AT), and
sending the fourth authentication token to the server;
wherein the server is further configured to perform:
receiving and authenticating the fourth authentication token (AT), and
generating a fifth authentication token for the second computing device; and sending the fifth authentication token (AT) to the second computing device; and
wherein the second computing device is configured to perform:
receiving and authenticating the fifth authentication token (AT), thereby performing a mutual authentication of the second computing device and the server.

US Pat. No. 10,511,571

TECHNIQUES FOR SOLVING OVERHEARING PROBLEMS OF BODY AREA NETWORK MEDIUM ACCESS CONTROL PROTOCOLS

Koninklijke Philips N.V.,...

1. A method for communicating between a sender device and multiple receiver devices in a network, comprising:generating, in a sender device, a preamble frame;
encoding a destination address of a target receiver device in the preamble frame using a mathematical relationship between a length of the preamble frame and the destination address of the target receiver device in order to allow a receiver device to determine whether it is the target receiver device by comparing the length of the preamble frame to the destination address, wherein the mathematical relationship is further based on a smallest length frame that can be reliably detected by the receiver device; and
transmitting the preamble frame.

US Pat. No. 10,511,557

TELECOMMUNICATION AND MULTIMEDIA MANAGEMENT METHOD AND APPARATUS

VOXER IP LLC, San Franci...

1. A method for operating a video message service infrastructure on a network, the method comprising:receiving, at the video message service infrastructure, a video message transmitted by a sending device, the video message containing video media, the video media being transmitted as the video media is created;
generating, by the video message service infrastructure, two or more degraded versions of the video media of the video message, where each of the two or more degraded versions is created by degrading the quality of the video media by a different amount;
selecting one of the degraded versions of the video media based on an ascertained bandwidth on the network for delivering the video media from the video message service infrastructure to a recipient device on the network; and
transmitting the selected degraded version of the video media from the video message service infrastructure to the recipient device so that the recipient device can render at least a portion of the video media on the recipient device, the video message service infrastructure operating so that the rendering occurs:
(i) while the video media of the video message is being created and transmitted over the network by the sending device; and
(ii) without having to first establish an end-to-end connection over the network between the sending device and the recipient device before the sending device begins to transmit the video media of the video message.

US Pat. No. 10,511,526

NETWORK SYSTEM, NETWORK CONTROL METHOD, AND CONTROL APPARATUS

NEC CORPORATION, Tokyo (...

1. A network control apparatus for controlling a network having a multi-layer structure, comprising:a first controller configured to set up a first layer path that provides virtual network functions for a network service on a first layer;
a network monitor that monitors whether or not the network service on the first layer fulfills a required service level; and
a second controller configured to change, depending on a monitoring result, a setting of a packet header so that the first layer path will be switched at an end point of the network service,
wherein a resource on a second layer, which is a lower layer than the first layer, changes in accordance with a change in the setting of the packet header,
wherein the second controller is configured to repeat the changing of the setting of the packet header, responsive to determining that the network service after the setting of the packet header is changed does not fulfill the service level.

US Pat. No. 10,511,257

PHOTOVOLTAIC CELL HAVING POLARIZATION CHARACTERISTIC AND ELECTRONIC DEVICE HAVING THE SAME

Samsung Electronics Co., ...

1. A photovoltaic cell comprising:a first electrode and a second electrode having transparency and disposed facing each other; and
a photovoltaic cell layer disposed between the first and second electrodes, and configured to produce electric energy by absorbing a part of incident light,
wherein the photovoltaic cell layer comprises:
a plurality of unit cells disposed in a specific distance from each other and formed with a plurality of slits for polarizing the incident light; and
a transparent insulator disposed in the plurality of slits.

US Pat. No. 10,511,252

WATERPROOFING MOUNTING SYSTEM FOR ATTACHING SOLAR MODULES TO A ROOF

Quick Mount PV, Walnut C...

1. A waterproofing roof mounting system for attaching at least one solar module to a roof, the system comprising:(a.) a roof having a roof surface;
(b.) a plurality of mounts, each of the plurality of mounts comprising:
(i.) a base having a first surface adjacent the roof surface and a second surface opposite the first surface;
(ii.) a base projection extending away from the roof surface, the projection comprising a distal end having a distal end aperture;
(iii.) a block comprising a substantially horizontal portion and a substantially vertical portion, wherein the substantially horizontal portion has an opening and is configured to fit over the base and base projection, and wherein the vertical portion has a slotted opening;
(iv.) a tightening means attaching the block and base to the roof, the tightening means having a long portion and a head portion; and
(v.) a sealing washer between the head portion and the projection distal end,
(c.) a plurality of structural members each attached to the block vertical portion and each comprising a top portion and a groove in the top portion extending the length of each structural member; and
(d.) a plurality of clamp assemblies each connected to the at least one solar module and each configured to connect to the top portion of one of the structural members.

US Pat. No. 10,511,189

IMPLANTABLE MEDICAL DEVICE CHARGING

Cochlear Limited, Macqua...

1. An implantable medical device system, comprising:an inductive charger including a charger coil;
an external component including:
a rechargeable battery,
an inductive coil arrangement configured to form an inductive charging link with the charger coil to receive power signals from the inductive charger,
a voltage increasing converter configured to step-up a voltage of the power signals received from the inductive charger for use in charging the rechargeable battery, and
a voltage decreasing converter configured to step-down a voltage of signals obtained from the rechargeable battery; and
an implantable component including an implantable coil, wherein the inductive coil arrangement is further configured to form a transcutaneous link with the implantable coil to transmit at least one of data and power to the implantable component.

US Pat. No. 10,511,163

LOW CAPACITANCE SURGE SUPPRESSION DEVICE

General Electric Company,...

1. A surge suppression device, comprising:a micro electromechanical system (MEMS) switch electrically connected to a current path;
a voltage clamping transient voltage suppression (TVS) device electrically connected in series to the MEMS switch, wherein the MEMS switch is configured to switch between an open state and a closed state, the MEMS switch is configured to facilitate current flow from the current path to the voltage clamping TVS device when the MEMS switch is in the closed state, and the MEMS switch is configured to block current flow from the current path to the voltage clamping TVS device when the MEMS switch is in the open state, and a capacitance of the voltage clamping TVS device is reduced by at least 80% when the MEMS switch is in the open state; and
a control circuitry operatively coupled to the MEMS switch and configured to control switching of the MEMS switch based on a measured level of current or a measured level of voltage in the current path, wherein the control circuitry is configured to switch the MEMS switch from the open state to the closed state when the measured level of current is greater than a current threshold or when the measured level of voltage is greater than a voltage threshold;
wherein the current threshold and voltage threshold comprise one of:
a minimum value of transient current or transient voltage in the current path that defines a transient surge current or transient surge voltage; or
a pre-defined percentage of the minimum value of transient current or transient voltage in the current path that defines a transient surge current or transient surge voltage.

US Pat. No. 10,510,959

COMMISSIONING METHOD AND VAPOR DEPOSITION MACHINE

Wuhan China Star Optoelec...

1. A commissioning method for adjusting the relative position of a precision mask plate and a substrate to be operated, which comprises:Loading a commissioning substrate into a vapor deposition chamber for commissioning, wherein the commissioning substrate comprises a substrate, and the commissioning substrate further comprises a photo chromic layer and an anode thin film layer arranged on the substrate, and one of the photo chromic layer and the anode thin film layer is pre-patterned;
loading the precision mask plate into the vapor deposition chamber for commissioning, wherein the precision mask plate comprises a light transmission area and the light blocking area;
after aligning the precision mask plate and the commissioning substrate, turning on a light source in the vapor deposition chamber for commissioning, and irradiating the photo chromic layer on the commissioning substrate via the precision mask plate, wherein a partial position of the irradiated photo chromic layer is discolored;
obtaining a compensation value of the precision mask plate by the location of a partial discolored position of the photo chromic layer, wherein the compensation value is used for the vapor deposition machine to adjust the relative position of the precision mask plate and the substrate to be operated;
wherein when the photo chromic layer on the commissioning substrate is pre-patterned, the patterned photo chromic layer is arranged on the anode thin film layer; the above-mentioned description of turning on the light source in the vapor deposition chamber for commissioning and irradiating the photo chromic layer on the commissioning substrate via the precision mask plate, which comprises: the irradiation light passing through the light transmission area in the precision mask plate and irradiating the patterned photo chromic layer, so that the discoloration phenomenon is occurred in the position corresponding to the light transmission area in the patterned photo chromic layer; wherein the position where the discoloration phenomenon occurs in the photo chromic layer is a position between the edge of the light transmissive area of the precision mask plate and the edge of the patterned photo chromic layer;
wherein when the anode thin film layer on the commissioning substrate is pre-patterned, the patterned anode thin film layer is arranged on the photo chromic layer; the above-mentioned description of turning on the light source in the vapor deposition chamber for commissioning and irradiating the photo chromic layer on the commissioning substrate via the precision mask plate, which comprises: the irradiation light passing through the light transmission area in the precision mask plate and the patterned anode thin film layer, and irradiating the photo chromic layer, so that the discoloration phenomenon is occurred in a partial position of the irradiated photo chromic layer; wherein the discoloration phenomenon occurs in the photo chromic layer is a position between the edge of the light transmissive area of the precision mask plate and the edge of the patterned anode thin film layer.

US Pat. No. 10,510,612

LOW-K GATE SPACER AND FORMATION THEREOF

Taiwan Semiconductor Manu...

1. A structure comprising:an active area on a semiconductor substrate;
a gate structure on the active area and over the semiconductor substrate, the gate structure comprising a conformal gate dielectric on the active area and comprising a gate electrode over the conformal gate dielectric;
a first gate spacer on the active area and along a sidewall of the gate structure, the conformal gate dielectric extending vertically along a first sidewall of the first gate spacer, wherein a material of the first gate spacer has a dielectric constant equal to or less than 3.9;
an inhibitor layer interposed between the first gate spacer and the semiconductor substrate, wherein the inhibitor layer comprises SiOR3, wherein R represents an alkyl-group; and
a second gate spacer adjacent the first gate spacer, the second gate spacer is in direct contact with the active area of the semiconductor substrate, wherein the first gate spacer is spaced apart from the active area of the semiconductor substrate.

US Pat. No. 10,510,576

CARRIER-BONDING METHODS AND ARTICLES FOR SEMICONDUCTOR AND INTERPOSER PROCESSING

CORNING INCORPORATED, Co...

1. An article, comprising:a carrier with a carrier bonding surface;
a wafer sheet with at least one via therein, the sheet further comprising a sheet bonding surface;
a surface modification layer;
the carrier bonding surface being bonded with the sheet bonding surface with the surface modification layer therebetween, the surface modification layer being in direct contact with both the carrier bonding surface and the sheet bonding surface, wherein the surface modification layer is of such a character that at least one of:
(i) after subjecting the article to a temperature cycle by heating in an chamber cycled from room temperature to 600° C. at a rate of 9.2° C. per minute, held at a temperature of 600° C. for 10 minutes, and then cooled at furnace rate to 300° C., and then removing the article from the chamber and allowing the article to cool to room temperature, the carrier and sheet do not separate from one another if one is held and the other subjected to the force of gravity, and the sheet may be separated from the carrier without breaking the carrier and the sheet into two or more pieces when separation of the sheet from the carrier is performed at room temperature; and
(ii) after subjecting the article to a temperature cycle by heating in an chamber cycled from room temperature to 400° C. at a rate of 9.2° C. per minute, held at a temperature of 400° C. for 10 minutes, and then cooled at furnace rate to 300° C., and then removing the article from the chamber and allowing the article to cool to room temperature, the carrier and sheet do not separate from one another if one is held and the other subjected to the force of gravity, there is no outgassing from the surface modification layer according to Outgassing TEST #2, and the sheet may be separated from the carrier without breaking the carrier and the sheet into two or more pieces when separation of the sheet from the carrier is performed at room temperature, wherein Outgassing TEST #2 is performing the following steps, in order:
scanning the article with an Epson Expression 10000XL Photo desktop scanner, in transmission mode, to make a first scan of the area bonding the thin sheet and carrier after assembling the article, and before time-temperature cycling of the article, wherein the desktop scanner is operated with the standard Epson software using 508 dpi (50 micron/pixel) and 24 bit RGB;
using image processing software to prepare a first image by stitching, as necessary, scans of different sections of the article into the first image, and removing scanner artifacts by using a calibration reference scan performed without an article in the scanner;
analyzing the first image of the bonded area using image processing techniques of thresholding, hole filling, erosion/dilation, and blob analysis, as necessary;
determining a first bubble area by totaling bubble areas visible in the first image;
comparing the first bubble area with the total bonding area to calculate a first percent bubble area of the bubbles in the bonding area relative to the total bonding area;
putting the article through the desired time-temperature cycle, by processing in a MPT-RTP600s Rapid Thermal Processing system under N2 atmosphere;
scanning the article a second time with the scanner, and processing in the above-noted manner to determine a second percent bubble area;
calculating a change in percent bubble area by determining the difference between the first percent bubble area and the second percent bubble area;
wherein outgassing is evidenced if the change in percent bubble area is ?5.

US Pat. No. 10,510,478

STACKED COIL FOR WIRELESS CHARGING STRUCTURE ON INFO PACKAGE

Taiwan Semiconductor Manu...

1. A structure comprising:a first coil;
a second coil over the first coil; and
an interconnect structure between and interconnecting the first coil and the second coil, the interconnect structure comprising:
a first dielectric layer;
a first via in the first dielectric layer;
a first molding compound over the first dielectric layer;
a through-molding via in the first molding compound;
a second dielectric layer over the first molding compound; and
a second via in the second dielectric layer, wherein the first via, the through-molding via, and the second via are serially connected.

US Pat. No. 10,510,336

METHOD, APPARATUS, AND SYSTEM FOR CONFLICT DETECTION AND RESOLUTION FOR COMPETING INTENT CLASSIFIERS IN MODULAR CONVERSATION SYSTEM

International Business Ma...

1. An information handling system comprising:one or more processors;
a memory coupled to at least one of the processors;
a set of instructions stored in the memory and executed by at least one of the processors to resolve training data conflicts, wherein the set of instructions are executable to perform actions of:
retrieving, by the system, first and second independent training data sets corresponding, respectively, to first and second independently trained classifiers, each training data set comprising a plurality of intents and end-user utterances for use in training the first and second independently trained classifiers to recognize a corresponding intent from one or more of the end-user utterances;
training, by the system, the first and second independently trained classifiers using, respectively, the first and second independent data sets;
providing, by the system, a first end-user utterance test data associated with a first intent to the first and second independently trained classifiers to select an output intent generated by the first and second independently trained classifiers;
identifying, by the system, a first conflict when the first intent associated with the first end-user utterance test data does not match the output intent; and
automatically generating, by the system, one or more conflict resolution recommendations for display and selection by an end user to resolve the first conflict by displaying a user-actuable mechanism for turning off and not deleting one or more of the plurality of intents to resolve the first conflict.

US Pat. No. 10,510,335

MACHINE AND METHOD FOR ACOUSTIC WHITE NOISE GENERATION

1. A machine for generating acoustic white noise comprising:an oblate housing comprising a top portion and a bottom portion each of which have an inner surface and an outer surface, wherein said top portion and said bottom portion are configured to securely engage each other via an attachment means displaced along a rim of at least one of said top portion and said bottom portion to form a cavity defined by said inner surface of said top portion and bottom portion;
said oblate housing further comprising a curved wall, said curved wall comprising a cylindrical frame displaced concentrically within a cylindrical band, said curved wall further comprising a plurality of openings, wherein a rotational displacement of said cylindrical band relative to said cylindrical frame determines a dimensions of each of said openings;
a motor enclosure displaced within said housing, said motor enclosure comprising a motor secured therein, and said motor enclosure further configured with a means to isolate noise and vibration;
a fan mounted on said motor, said fan comprising a concave central dome and further comprising a plurality of blades, wherein said concave central dome is shaped to partially wrap around said motor enclosure and each of said blades comprise a first end integrally fused to said concave central dome and a second end forming a blade tip;
a substantially rigid shell configured to envelop said housing, wherein said shell is rotatably connected to said housing to adjust the length and depth of said openings;
a power source and a circuit board electrically connected to each other, said power source and said circuit board electrically connected to said motor to regulate a operation of said fan; and
a physical control means disposed on said top portion adapted to effectuate manual regulation of the operation of said fan.

US Pat. No. 10,510,281

IMAGE PROCESSING APPARATUS AND METHOD, AND ELECTRONIC DEVICE

SAMSUNG ELECTRONICS CO., ...

1. An image processing method comprising:calculating color characteristics of input pixel data;
determining whether the pixel data is achromatic based on the color characteristics;
performing a first rendering on the pixel data in response to determining that the pixel data is not achromatic; and
performing a second rendering on the pixel data in response to determining that the pixel data is achromatic,
wherein the performing the first rendering comprises performing a rendering on the pixel data according to a predetermined basic weight set, and
wherein the performing the second rendering comprises performing a rendering on the pixel data according to a first weight set and a second weight set which are set by a user.