US Pat. No. 10,457,689

AMMONIUM DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

LES LABORATOIRES SERVIER,...

1. A compound of formula (I):
wherein:
Y represents a —NH— group or an oxygen atom;
R1 represents a linear or branched (C1-C6)alkyl group, a linear or branched (C2-C6)alkenyl group, a linear or branched (C2-C6)alkynyl group, a linear or branched (C1-C6)alkoxy group, a —S—(C1-C6)alkyl group, a linear or branched (C1-C6)polyhaloalkyl group, a hydroxy group, a hydroxy(C1-C6)alkyl group, a cyano group, —NR9R9?, —Cy1 or a halogen atom;
R2, R3 and R4 independently of one another represent a hydrogen atom, a halogen atom, a linear or branched (C1-C6)alkyl group, a linear or branched (C2-C6)alkenyl group, a linear or branched (C2-C6)alkynyl group, a linear or branched (C1-C6)polyhaloalkyl, a hydroxy group, a hydroxy(C1-C6)alkyl group, a linear or branched (C1-C6)alkoxy group, a —S—(C1-C6)alkyl group, a cyano group, a nitro group, -alkyl(C0-C6)—NR9R9?, —O-alkyl(C1-C6)—NR9R9?, —C(O)—OR9, —O—C(O)—R9, —C(O)—NR9R9?, —NR9—C(O)—R9?, —NR9—C(O)—OR9?, -alkyl(C1-C6)—NR9—C(O)—R9?, —SO2—NR9R9?, or —SO2-alkyl(C1-C6);
R5 represents a hydrogen atom;
R6 represents the group

R7 represents a hydrogen atom or a linear or branched (C1-C6)alkyl group;
R8 represents a —O—P(O)(O?)(O?) group, a —O—P(O)(O?)(OR10) group, a —O—P(O)(OR10)(OR10?) group, a —O—SO2—O? group, a —O—SO2—OR10 group, —Cy2, a —O—C(O)—R9 group, a —O—C(O)—OR, group or a —O—C(O)—NR9R9? group;
R9 and R9? independently of one another represent a hydrogen atom, a linear or branched (C1-C6)alkyl group or a linear or branched amino(C1-C6)alkyl group;
R10 and R10? independently of one another represent a hydrogen atom, a linear or branched (C1-C6)alkyl group or an arylalkyl(C1-C6) group;
Cy1 and Cy2 independently of one another, represent a cycloalkyl group, a heterocycloalkyl group, an aryl group or a heteroaryl group;
wherein the ammonium so defined may exist as a zwitterionic form or may have a monovalent anionic counterion,
and wherein:
“aryl” means a phenyl or naphthyl group,
“heteroaryl” means any mono- or bi-cyclic group composed of from 5 to 10 ring members, having at least one aromatic moiety and having from 1 to 3 heteroatoms selected from oxygen, sulphur and nitrogen,
“cycloalkyl” means any mono- or bi-cyclic non-aromatic carbocyclic group having from 3 to 10 ring members,
“heterocycloalkyl” means any mono- or bi-cyclic non-aromatic carbocyclic group having from 3 to 10 ring members, and having from 1 to 3 heteroatoms selected from oxygen, sulphur and nitrogen, which may have fused, bridged or spiro ring systems,
wherein the aryl, heteroaryl, cycloalkyl and heterocycloalkyl groups so defined and the alkyl, alkenyl, alkynyl, alkoxy groups, to be substituted by from 1 to 4 groups selected from linear or branched (C1-C6)alkyl, linear or branched (C2-C6)alkenyl group, linear or branched (C2-C6)alkynyl group, linear or branched (C1-C6)alkoxy, (C1-C6)alkyl-S—, hydroxy, oxo (or N-oxide where appropriate), nitro, cyano, —C(O)—OR?, —O—C(O)—R?, —C(O)—NR?R?, —NR?R?, —(C?NR?)—OR?, linear or branched (C1-C6)polyhaloalkyl, trifluoromethoxy or halogen, wherein R? and R? independently of one another represent a hydrogen atom or a linear or branched (C1-C6)alkyl group, and wherein one or more of the carbon atoms of the preceding possible substituents, may be deuterated,
its enantiomers, diastereoisomers and atropisomers, and addition salts thereof with a pharmaceutically acceptable acid or base.

US Pat. No. 10,457,688

MONOCYCLIC THIENO, PYRIDO, AND PYRROLO PYRIMIDINE COMPOUNDS AND METHODS OF USE AND MANUFACTURE OF SAME

Duquesne University of Th...

3. A compound of Formula XXX:wherein X is CH2 ; and R1 is H or CH3; or a salt or a hydrate of said compound.

US Pat. No. 10,457,687

AMINOACID DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

LES LABORATOIRES SERVIER,...

1. A compound of formula (I):
wherein:
A represents the group

wherein 1 is linked to the —NH— group and 2 is linked to the aromatic ring,
E represents a cycloalkyl group, a heterocycloalkyl group, an aryl group or a heteroaryl group;
X represents a nitrogen atom or a C—R4 group,
Y represents a nitrogen atom or a C—R3 group,
R1 represents a halogen atom, a linear or branched (C1-C6)alkyl group, a linear or branched (C2-C6)alkenyl group, a linear or branched (C2-C6)alkynyl group, a linear or branched (C1-C6)polyhaloalkyl group, a hydroxy group, a hydroxy(C1-C6)alkyl group, a linear or branched (C1-C6)alkoxy group, —S—(C1-C6)alkyl, a cyano group, a nitro group, -alkyl(C0-C6)—NR9R9?, —O-alkyl(C1-C6)—NR9R9?, —O-alkyl(C1-C6)—R10, —C(O)—OR9, —O—C(O)—R9, —C(O)—NR9R9?, —NR9—C(O)—R9?, —NR9—C(O)—OR9?, -alkyl(C1-C6)—NR9—C(O)—R9?, —SO2—NR9R9?, or —SO2-alkyl(C1-C6),
R2, R3, R4 and R5, independently of one another, represent a hydrogen atom, a halogen atom, a linear or branched (C1-C6)alkyl group, a linear or branched (C2-C6)alkenyl group, a linear or branched (C2-C6)alkynyl group, a linear or branched (C1-C6)polyhaloalkyl group, a hydroxy group, a hydroxy(C1-C6)alkyl group, a linear or branched (C1-C6)alkoxy group, —S—(C1-C6)alkyl, a cyano group, a nitro group, -alkyl(C0-C6)—NR9R9?, —O-alkyl(C1-C6)—NR9R9?, —O-alkyl(C1-C6)—R10, —C(O)—OR9, —O—C(O)—R9, —C(O)—NR9R9?, —NR9—C(O)—R9?, —NR9—C(O)—OR9?, -alkyl(C1-C6)—NR9—C(O)—R9?, —SO2—NR9R9?, or —SO2-alkyl(C1-C6),
or the substituents of the pair (R1, R2), together with the carbon atoms carrying them, form an aromatic or non-aromatic ring having from 5 to 7 ring members, which may contain from 1 to 3 heteroatoms selected from oxygen, sulphur and nitrogen, wherein the resulting ring may be substituted by from 1 to 2 groups selected from the group consisting of halogen, linear or branched (C1-C6)alkyl, -alkyl(C0-C6)—NR9R9?, —NR11R11?, -alkyl(C0-C6)-Cy1, and oxo,
R6 represents a hydrogen atom, a halogen atom, a linear or branched (C1-C6)alkyl group, a linear or branched (C2-C6)alkenyl group, a linear or branched (C2-C6)alkynyl group, a linear or branched (C1-C6)polyhaloalkyl group, a hydroxy group, a linear or branched (C1-C6)alkoxy group, —S—(C1-C6)alkyl, a cyano group, a nitro group, -alkyl(C0-C6)—NR9R9?, —O-Cy1, -alkyl(C0-C6)-Cy1, -alkenyl(C2-C6)-Cy1, -alkynyl(C2-C6)-Cy1, —O-alkyl(C1-C6)—R10, —C(O)—OR9, —O—C(O)—R9, —C(O)—NR9R9?, —NR9—C(O)—R9?, —NR9—C(O)—OR9?, -alkyl(C1-C6)—NR9—C(O)—R9?, —SO2—NR9R9?, or SO2-alkyl(C1-C6),
R7 represents a hydrogen atom, a linear or branched (C1-C8)alkyl group, a —CHRaRb group, an aryl group, a heteroaryl group, an arylalkyl(C1-C6) group, or a heteroarylalkyl(C1-C6) group,
R8 represents a linear or branched (C1-C6)alkyl group, a linear or branched (C2-C6)alkenyl group, a linear or branched (C2-C6)alkynyl group, -Cy2, a halogen atom, a cyano group, —C(O)—R11, or —C(O)—NR11R11?,
R9 and R9?, independently of one another, represent a hydrogen atom, a linear or branched (C1-C6)alkyl group,
or the substituents of the pair, (R9, R9?), together with the nitrogen atom carrying them, form an aromatic or non-aromatic ring having from 5 to 7 ring members, which may contain, in addition to the nitrogen atom, from 1 to 3 heteroatoms selected from oxygen, sulphur and nitrogen, wherein the nitrogen may be substituted by a hydrogen atom or a linear or branched (C1-C6)alkyl group,
R10 represents -Cy3, -Cy3-alkyl(C0-C6)-Cy4, —C(O)—NR9NR9?, —NR9R9?, —OR9, —NR9—C(O)—R9?, —O-alkyl(C1-C6)—OR9, —SO2—R9, —C(O)—OR9, or —NH—C(O)—NH—R9,
R11 and R11?, independently of another, represent a hydrogen atom or an optionally substituted linear or branched (C1-C6)alkyl group,
R12 represents a hydrogen atom, a hydroxy group, or a hydroxy(C1-C6)alkyl group,
Ra represents a hydrogen atom or a linear or branched (C1-C6)alkyl group,
Rb represents a —O—C(O)—O—Rc group, a —O—C(O)—NRcRc? group, or a —O—P(O)(ORc)2 group,
Rc and Rc?, independently of one another, represent a hydrogen atom, a linear or branched (C1-C8)alkyl group, a cycloalkyl group, a (C1-C6)alkoxy(C1-C6)alkyl group, a (C1-C6)alkoxycarbonyl(C1-C6)alkyl group,
or the substituents of the pair (Rc, Rc?), together with the nitrogen atom carrying them, form a non-aromatic ring having from 5 to 7 ring members, which may contain, in addition to the nitrogen atom, from 1 to 3 heteroatoms selected from oxygen and nitrogen, wherein the nitrogen may be substituted by a linear or branched (C1-C6)alkyl group,
Cy1, Cy2, Cy3 and Cy4, independently of one another, represent a cycloalkyl group, a heterocycloalkyl group, an aryl group or a heteroaryl group,
n is an integer equal to 0, 1 or 2,
wherein:
“aryl” means a phenyl, naphthyl, biphenyl group,
“heteroaryl” means any mono- or bi-cyclic group composed of from 5 to 10 ring members, having at least one aromatic moiety and containing from 1 to 3 heteroatoms selected from oxygen, sulphur and nitrogen,
“cycloalkyl” means any mono- or bi-cyclic non-aromatic carbocyclic group containing from 3 to 10 ring members,
“heterocycloalkyl” means any mono- or bi-cyclic non-aromatic carbocyclic group containing from 3 to 10 ring members, and containing from 1 to 3 heteroatoms selected from oxygen, sulphur and nitrogen, which may include fused, bridged or spiro ring systems,
and wherein the aryl, heteroaryl, cycloalkyl and heterocycloalkyl groups so defined and the alkyl, alkenyl, alkynyl, alkoxy groups may be substituted by from 1 to 4 groups selected from the group consisting of optionally substituted linear or branched (C1-C6)alkyl, optionally substituted linear or branched (C2-C6)alkenyl, optionally substituted linear or branched (C2-C6)alkynyl, optionally substituted linear or branched (C1-C6)alkoxy, optionally substituted (C1-C6)alkyl-S—, hydroxy, hydroxy(C1-C6)alkyl, oxo (or N-oxide where appropriate), nitro, cyano, —C(O)—OR?, —O—C(O)—R?, —C(O)—NR?R?, —O—C(O)—NR?R?, —NR?R?, —(C?NR?)—OR?, —O—P(O)(OR?)2, —O—P(O)(O?M+)2, linear or branched (C1-C6)polyhaloalkyl, trifluotomethoxy, halogen, and an aldohexose of formula:

in which each R? is independent;
wherein R? and R?, independently of one another, represent a hydrogen atom or an optionally substituted linear or branched (C1-C6)alkyl group and M+ represents a pharmaceutically acceptable monovalent cation,
its enantiomers, diastereoisomers and atropisomers, and addition salts thereof with a pharmaceutically acceptable acid or base.

US Pat. No. 10,457,686

[1,2,3]TRIAZOLO[4,5-D]PYRIMIDINE DERIVATIVES

Hoffmann-La Roche Inc., ...

1. A compound of formula (I)
wherein
R1 is a ring selected from phenyl, [1,2,5]oxadiazolyl, pyridinyl and pyrimidinyl, wherein said ring is substituted with one substituent selected from haloalkyldiazirenyl and alkynyldiazirenylalkylaminocarbonyl and optionally further substituted with halogen or cyano;
R2 and R3 are independently selected from hydrogen, halogen and hydroxyl; and
R4 is alkyl or phenylhaloalkyl;
or a pharmaceutically acceptable salt or ester thereof.

US Pat. No. 10,457,685

[1,2,3]TRIAZOLO[4,5-D]PYRIMIDINE DERIVATIVES WITH AFFINITY FOR THE TYPE-2 CANNABINOID RECEPTOR

Hoffmann-La Roche Inc., ...

1. A compound of formula (I)
wherein
R1 is a ring selected from phenyl and [1,2,5]oxadiazolyl wherein said ring is substituted with one substituent selected from halosulfonyl, halosulfonylalkyl, isothiocyanatoalkyl, isothiocyanato, aminoalkyldisulfanylalkyl, hydroxyalkyldisulfanylalkyl, hydroxyalkyldisulfanyl, aminoalkyldisulfanyl, halogen, alkyl, pyridinyldisulfanylalkyl, benzotriazolylsulfonylalkyl, dihydroxyalkyldisulfanylalkyl and pyridinyldisulfanyl and optionaly further substituted with cyano;
R2 and R3 are independently selected from hydrogen, hydroxyl, halogen, thiohydroxyl, thiohydroxyazetidinyl, azido, isothiocyanato and alkyl disulfanyl;
provided that at least one of R1, R2 and R3 is a group comprising sulfonyl, isothiocyanato, disulfanyl, thiohydroxyl or azido;
R4 is alkyl or phenylhaloalkyl; and
n is 0 or 1;
or a pharmaceutically acceptable salt or ester thereof.

US Pat. No. 10,457,684

[1,2,3]TRIAZOLO[4,5-D]PYRIMIDINE DERIVATIVES

Hoffmann-La Roche Inc., ...

1. A compound of formula (I)
wherein
R1 is a ring selected from phenyl, [1,2,5]oxadiazolyl, pyridinyl, pyrimidinyl and isoxazolyl, wherein said ring is substituted with one or two substituents independently selected from alkyl, haloalkyl, halogen, alkenyl, haloalkyldiazirenyl, alkynyldiazirenylalkylaminocarbonyl, alkynyldiazirenylalkylaminoalkyl, alkynyldiazirenylalkyloxyalkyl, alkynyldiazirenylalkylamino, alkynyldiazirenylalkyloxy and cyano;
R2 and R3 are independently selected from hydrogen, halogen and hydroxyl;
or R2and R3 together with the carbon atom to which they are attached form diazirenyl;
provided that at least one of R1 or R2 and R3 is a group comprising diazirenyl; and
R4 is alkyl or phenylhaloalkyl;
or a pharmaceutically acceptable salt or ester thereof.

US Pat. No. 10,457,683

ARYL HYDROCARBON RECEPTOR ANTAGONISTS AND USES THEREOF

Magenta Therapeutics Inc....

1. A compound represented by formula (I-e) or (II-e)
wherein A is an optionally substituted ring system selected from the group consisting of phenyl, 1H-indol-2-yl, 1H-indol-3-yl, thiophen-3-yl, pyridin-2-yl, pyridin-3-yl, pyridin-4-yl, 1H-1,2,4-triazol-3-yl, 1H-1,2,4-triazol-5-yl, 2-oxoimidazolidin-1-yl, 1H-pyrazol-3-yl, 1H-pyrazol-4-yl, and 2-oxo-2,3-dihydro-1H-benzo[d]imidazol-5-yl, wherein the phenyl, 1H-indol-2-yl, 1H-indol-3-yl, thiophen-3-yl, pyridin-2-yl, pyridin-3-yl, pyridin-4-yl, 1H-1,2,4-triazol-3-yl, 1H-1,2,4-triazol-5-yl, 2-oxoimidazolidin-1-yl, 1H-pyrazol-3-yl, 1H-pyrazol-4-yl, or 2-oxo-2,3-dihydro-1H-benzo[d]imidazol-5-yl is optionally substituted with from 1 to 3 substituents independently selected from the group consisting of cyano, hydroxy, C1-4 alkyl, C1-4 alkoxy, halo, halo-substituted-C1-4 alkyl, halo-substituted-C1-4 alkoxy, amino, —O(CH2)2NR10aR10b, —S(O)2NR10aR10b, —OS(O)2NR10aR10b, and —NR10aS(O)2R10b, wherein R10a and R10b are each independently selected from the group consisting of hydrogen, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted alkyl, optionally substituted heteroalkyl, optionally substituted cycloalkyl, and optionally substituted heterocycloalkyl;
B is an optionally substituted ring system selected from the group consisting of thiophen-2-yl, thiophen-3-yl, furan-3-yl, 1H-benzo[d]imidazol-1-yl, isoquinolin-4-yl, 1H-imidazo[4,5-b]pyridin-1-yl, imidazo[1,2-a]pyridin-3-yl, benzo[b]thiophen-3-yl, pyrimidin-5-yl, pyridin-2-yl, pyridin-3-yl, pyridin-4-yl, 1H-imidazol-1-yl, pyrazin-2-yl, pyridazin-4-yl, 1H-pyrrol-2-yl and thiazol-5-yl, wherein the thiophen-2-yl, thiophen-3-yl, furan-3-yl, 1H-benzo[d]imidazol-1-yl, isoquinolin-4-yl, 1H-imidazo[4,5-b]pyridin-1-yl, benzo[b]thiophen-3-yl, pyrimidin-5-yl, pyridin-2-yl, pyridin-3-yl, pyridin-4-yl, 1H-imidazol-1-yl, pyrazin-2-yl, pyridazin-4-yl, 1H-pyrrol-2-yl, or thiazol-5-yl is optionally substituted with from 1 to 3 substituents independently selected from the group consisting of cyano, hydroxy, C1-4 alkyl, C2-4 alkenyl, C2-4 alkynyl, C3-6 cycloalkyl, C1-4 alkoxy, halo, halo-substituted-C1-4 alkyl, halo-substituted-C1-4 alkoxy, amino, —C(O)R11a, —S(O)0-2R11a, —C(O)OR11a, and —C(O)NR11aR11b, wherein R11a and R11b are each independently selected from the group consisting of hydrogen and C1-4 alkyl; and
R5 is selected from the group consisting of C1-10 alkyl, prop-1-en-2-yl, cyclohexyl, cyclopropyl, 2-(2-oxopyrrolidin-1-yl)ethyl, oxetan-2-yl, oxetan-3-yl, benzhydryl, tetrahydro-2H-pyran-2-yl, tetrahydro-2H-pyran-3-yl, phenyl, tetrahydrofuran-3-yl, benzyl, (4-pentylphenyl)(phenyl)methyl, and 1-(1-(2-oxo-6,9,12-trioxa-3-azatetradecan-14-yl)-1H-1,2,3-triazol-4-yl)ethyl, wherein the C1-10 alkyl, prop-1-en-2-yl, cyclohexyl, cyclopropyl, 2-(2-oxopyrrolidin-1-yl)ethyl, oxetan-2-yl, oxetan-3-yl, benzhydryl, tetrahydro-2H-pyran-2-yl, tetrahydro-2H-pyran-3-yl, phenyl, tetrahydrofuran-3-yl, benzyl, (4-pentylphenyl)(phenyl)methyl, or 1-(1-(2-oxo-6,9,12-trioxa-3-azatetradecan-14-yl)-1H-1,2,3-triazol-4-yl)ethyl is optionally substituted with from 1 to 3 substituents independently selected from the group consisting of hydroxy, C1-4 alkyl, and halo-substituted-C1-4alkyl, or R5 is selected from the group consisting of (i), (ii), (iii), (iv), and (v)

wherein n is an integer from 1 to 6, m is an integer from 0 to 6, p is an integer from 0 to 5, and each R is independently selected from the group consisting of cyano, hydroxy, C1-4 alkyl, C2-4 alkenyl, C2-4 alkynyl, C3-6 cycloalkyl, C1-4 alkoxy, halo, halo-substituted-C1-4 alkyl, halo-substituted-C1-4 alkoxy, amino, —C(O)R12a, —S(O)0-2R12a, —C(O)OR12a, and —C(O)NR12aR12b, and wherein R12a and R12b are each independently selected from the group consisting of hydrogen and C1-4 alkyl;
or a salt thereof.

US Pat. No. 10,457,682

SMALL MOLECULES THAT BIND MR1

1. A method of treating a respiratory infection of Mycobacterium tuberculosis or Streptococcus pyogenes in a human subject, the method comprising administering to the human subject in need thereof a pharmaceutically effective amount of a compound selected from Formula 1b, Formula 2b, and Formula 3b, or a pharmaceutically acceptable salt thereof:
wherein, in each appearance:
R1 is independently selected from H, OH, C1-C3 alkyl, and —CH?O;
R2 is independently selected from H, a 5-10-membered carbocycle, a 5-10-membered heterocycle, and
C1-C3 alkyl, wherein the C1-C3 alkyl can be substituted by 1 or 2 substituents selected from OH and CO2H;
R3 is selected from OH and —O(C?O)—C1-C3 alkyl;
R4 is independently selected from H, OH, C1-C3 alkyl, and —CH?O;
R5 is independently selected from H, a 5-10-membered carbocycle, a 5-10-membered heterocycle, and
C1-C3 alkyl, wherein the C1-C3 alkyl can be substituted by 1 or 2 substituents selected from OH and CO2H;
R6 is selected from OH and —O(C?O)-C1-C3 alkyl; and
R7 is H or OH.

US Pat. No. 10,457,681

TOLL-LIKE RECEPTOR 7 (TLR7) AGONISTS HAVING A TRICYCLIC MOIETY, CONJUGATES THEREOF, AND METHODS AND USES THEREFOR

Bristol_Myers Squibb Comp...

1. A compound having a structure according to formula (I), (II), or (III)whereinR1 is (C1-C5 alkyl)O, (C1-C2 alkyl)O(CH2)2-3O, (C1-C5 alkyl)C(?O)O, (C1-C5 alkyl)NH, (C1-C2 alkyl)O(CH2)2-3NH, or (C1-C5 alkyl)C(?O)NH;
R2 and R3 are, independently for each occurrence thereof, H, C1-C3 alkyl, halo, O(C1-C3 alkyl), CN, or NO2, where one R3 may be replaced by (CH2)xR4, where the subscript x is 1, 2, 3, or 4;
R4 is H, halo, OH, CN, NH2, NH(C1-C5 alkyl), N(C1-C5 alkyl)2, NH(C3-C6 cycloalkyl), NH(C4-C8 bicycloalkyl), NH(C6-C10 spirocycloalkyl), N(C3-C6 cycloalkyl)2, NH(CH2)1-3(aryl), N((CH2)1-3(aryl))2, a cyclic amine moiety having the structure

 a 6-membered aromatic or heteroaromatic moiety or a 5-membered heteroaromatic moiety;
wherein
an alkyl, cycloalkyl, bicycloalkyl, spirocycloalkyl, cyclic amine, 6-membered aromatic or heteroaromatic, or 5-membered heteroaromatic moiety is optionally substituted with one or more substituents selected from OH, halo, CN, (C1-C3 alkyl), O(C1-C3 alkyl), C(?O)(Me), SO2(C1-C3 alkyl), C(?O)(Et), NH2, NH(Me), N(Me)2, NH(Et), N(Et)2, and N(C1-C3 alkyl)2; and
a cycloalkyl, bicycloalkyl, spirocycloalkyl, or cyclic amine moiety may have a CH2 group replaced by O, S, NH, N(C1-C3 alkyl), or N(Boc);
R5 is, independently for each occurrence thereof, O, S or NR6;
R6 is H or C1-C3 alkyl;
X1 is, independently for each occurrence thereof, CR2 or N;
X2 is, independently for each occurrence thereof, CR3 or N; and
X3 is O, S, NH, N(C1-C3 alkyl), C?O, or N(C?O)(C1-C3 alkyl.

US Pat. No. 10,457,680

PROCESS FOR PREPARING A PARP INHIBITOR, CRYSTALLINE FORMS, AND USES THEREOF

BEIGENE, LTD., Grand Cay...

1. A compound of Formula I,wherein n is a number from 0.0 to 2.0; m is a number from 0.0 to 20.0; and wherein the solvent is formed by solvation of solvent selected from isopropanol, ethanol, methanol, acetone, THF, 1,4-dioxane, acetic acid, acetonitrile, water, or a combination thereof;wherein the compound has:a) a Crystalline Form D, which has a powder X-ray diffraction pattern comprising three or more diffraction peaks having 2? angle values independently selected from the group consisting of: 5.7±0.2, 6.4±0.2, 6.8±0.2, 9.3±0.2, 9.8±0.2, 10.3±0.2, 11.5±0.2, 12.4±0.2, 12.9±0.2, 13.4±0.2, 13.9±0.2, 17.8±0.2, 18.3±0.2, 18.8±0.2, 18.9±0.2, 23.7±0.2, 25.0±0.2, 25.7±0.2, 25.9±0.2, and 26.7±0.2 degrees; or
b) a Crystalline Form E, which has a powder X-ray diffraction pattern comprising three or more diffraction peaks having 2? angle values independently selected from the group consisting of: 6.2±0.2, 8.6±0.2, 9.5±0.2, 11.0±0.2, 11.5±0.2, 12.0±0.2, 12.5±0.2, 13.4±0.2, 13.8±0.2, 14.4±0.2, 14.7±0.2, 15.1±0.2, 15.3±0.2, 16.2±0.2, 16.9±0.2, 17.9±0.2, 18.3±0.2, 19.0±0.2, 19.5±0.2, 20.1±0.2, 21.3±0.2, 22.2±0.2, 22.9±0.2, 23.3±0.2, 24.2±0.2, 24.6±0.2, 25.1±0.2, 25.7±0.2, 26.3±0.2, 27.0±0.2, 27.4±0.2, and 30.9±0.2 degrees; or
c) a Crystalline Form F, which has a powder X-ray diffraction pattern comprising three or more diffraction peaks having 2? angle values independently selected from the group consisting of: 5.2±0.2, 6.3±0.2, 7.7±0.2, 9.7±0.2, 10.4±0.2, 11.8±0.2, 13.7±0.2, 15.6±0.2,17.5±0.2, 18.0±0.2, 19.5±0.2, 20.2±0.2, 21.7±0.2, 23.1±0.2, 24.7±0.2, 25.3±0.2, and 27.3±0.2 degrees; or
d) a Crystalline Form H, which has a powder X-ray diffraction pattern comprising four or more diffraction peaks having 2? angle values independently selected from the group consisting of: 9.5±0.2, 12.0±0.2, 13.5±0.2, 15.4±0.2, 17.0±0.2, 19.0±0.2, 23.0±0.2, 24.2±0.2, 27.0±0.2, 27.4±0.2, 31.0±0.2, 34.7±0.2, and 34.8±0.2 degrees; or
e) a Crystalline Form K, which has a powder X-ray diffraction pattern comprising three or more diffraction peaks having 2? angle values independently selected from the group consisting of: 6.4±0.2, 10.8±0.2, 12.6±0.2, 12.8±0.2, 19.2±0.2, 25.2±0.2, 25.8±0.2, 32.4±0.2, and 34.1±0.2 degrees; or
f) a Crystalline Form I, which has a powder X-ray diffraction pattern comprising four or more diffraction peaks having 2? angle values independently selected from the group consisting of: 9.8±0.2, 10.0±0.2, 11.1±0.2, 11.7±0.2, 12.9±0.2, 13.3±0.2, 13.9±0.2, 14.4±0.2, 17.1±0.2, 17.4±0.2, 17.6±0.2, 17.9±0.2, 18.4±0.2, 18.5±0.2, 19.4±0.2, 20.8±0.2, 21.9±0.2, 23.7±0.2, 26.4±0.2, 26.9±0.2, and 29.4±0.2 degrees; or
g) a Crystalline Form J, which has a powder X-ray diffraction pattern comprising four or more diffraction peaks having 2? angle values independently selected from the group consisting of: 6.4±0.2, 8.7±0.2, 9.9±0.2, 10.3±0.2, 11.7±0.2, 12.8±0.2, 13.9±0.2, 18.1±0.2, 19.3±0.2, 23.0±0.2, 23.8±0.2, and 25.8±0.2 degrees.

US Pat. No. 10,457,679

IMIDAZO[4,5-C]QUINOLIN-2-ONE COMPOUNDS AND THEIR USE IN TREATING CANCER

AstraZeneca AB, Sodertal...

1. A compound of Formula (I):
or a pharmaceutically acceptable salt thereof, where:
R1 is methyl;
R2 is hydro or methyl; or R1 and R2 together with the nitrogen atom to which they are bonded form an azetidinyl, pyrrolidinyl or piperidinyl ring;
R3 is hydro or fluoro;
R4 is hydro or methyl; and
R5 is hydro or fluoro.

US Pat. No. 10,457,678

SUBSTITUTED PYRROLO[2,3-B]PYRIDINES AS INHIBITORS OF CELLULAR NECROPTOSIS

Institut National de la S...

1. A compound of formula (I):or a pharmaceutically acceptable salt thereof,wherein:

where (i) when

 X1 is N and X2 is —N(Y)—, and (ii) when

 X1 is —N(Y)— and X2 is N;
Ralk is —(C1-C6)alkyl;
R1, R2, R3 and R4 are independently —H, -halo, —(C1-C6)alkyl, —CF3, —CN, —OR51, —NR52R53 or —OS(O)2NR54R55;
R5 is —H, —(C1-C6)alkyl or —O(C1-C6)alkyl;
R6, R7 and R8 are independently —H, -halo, —OR56, —NR57R58, —C(O)NR59R60, —C(O)R61, —R62C(O)OR63, —R64C(O)R65, —R66NR67R68, —R69OR70, —S(O)2R74, —OR75C(O)OR76, —OC(O)R77 or —C(O)OR78; or
R6, R7 and R8 are independently —(C1-C6)alkyl, —(C1-C6)alkyl-aryl, —(C1-C6)alkyl-heterocycloalkyl, -heterocycloalkyl, -aryl or -heteroaryl, each optionally substituted with one or more substituents selected from the group consisting of -oxo, -halo, —NO2, —CN, —OR79, —NR80R81, —SR82, —S(O)R83, —S(O)2R84, —S(O)2NR85R86, —OC(O)R87, —NR88C(O)R89, —NR90C(O)OR91, —C(O)OR92, —C(O)NR93R94, —C(O)OR95, —OC(O)NR96R97 and —C(O)R98;
R10, R11, R12, R25, R29, R51, R52, R53, R54, R55, R56, R57, R58, R59, R60, R61, R62, R63, R64, R65, R66, R67, R68, R69, R70, R74, R75, R76, R77, R78, R79, R80, R81, R82, R83, R84, R85, R86, R87, R88, R89, R90, R91, R92, R93, R94, R95, R96, R97 and R98 are independently —H or -halo; or
R10, R11, R12, R25, R29, R51, R52, R53, R54, R55, R56, R57, R58, R59, R60, R61, R62, R63, R64, R65, R66, R67, R68, R69, R70, R74, R75, R76, R77, R78, R79, R80, R81, R82, R83, R84, R85, R86, R87, R88, R89, R90, R91, R92, R93, R94, R95, R96, R97 and R98 are independently —(C1-C6)alkyl, —(C1-C6)alkyl-aryl, -heterocycloalkyl, -aryl or -heteroaryl, each optionally substituted with one or more substituents selected from the group consisting of -oxo, -halo, —(C1-C6)alkyl, —ORalk, —S(O)2Ralk, —C(O)ORalk and —C(O)Ralk; or
R57 and R58, together with the nitrogen atom to which they are attached, form a heterocycloalkyl group; and/or
R59 and R60, together with the nitrogen atom to which they are attached, form a heterocycloalkyl group; and/or
R67 and R68, together with the nitrogen atom to which they are attached, form a heterocycloalkyl group; and/or
R80 and R81, together with the nitrogen atom to which they are attached, form a heterocycloalkyl group; and/or
R85 and R86, together with the nitrogen atom to which they are attached, form a heterocycloalkyl group; and/or
R93 and R94, together with the nitrogen atom to which they are attached, form a heterocycloalkyl group; and/or
R96 and R97, together with the nitrogen atom to which they are attached, form a heterocycloalkyl group;
Y is —C(O)NR10R11, —C(O)R12, —S(O)2R25 or —C(O)OR29; and
Z is —CH2CH3.

US Pat. No. 10,457,677

IMIDAZOLONYLQUINOLINES AND THE USE THEREOF AS ATM KINASE INHIBITORS

Merck Patent GmbH, Darms...

1. A method for the sensitisation of cancer cells to an anticancer agent or ionising radiation or a combination thereof, comprising administering to a subject in need thereof an effective amount of a compound of formula (IV) or a pharmaceutically acceptable salt, solvate, tautomer or stereoisomer thereof,whereinHet1 denotes pyrazolyl, which is unsubstituted or mono-, di- or trisubstituted, independently of one another, by Hal or A,
A in each case independently denotes unbranched or branched alkyl having 1, 2, 3, 4, 5, or 6 C atoms, in which, independently of one another, 1, 2, 3, 4, or 5 H atoms are optionally replaced by Hal,
Hal denotes F, Cl, Br or I, and
HET is 3-difluoromethoxy-5-fluoropyridin-4-yl, 3-fluoro-5-methoxypyridin-4-yl, 3-fluoro-5-fluoromethoxypyridin-4-yl, or 3-fluoro-5-(trideuteriomethoxy)pyridin-4-yl.

US Pat. No. 10,457,676

CAPSAZEPINE ANALOGS FOR THE TREATMENT OF CANCER AND OTHER PROLIFERATIVE DISEASES

THE BOARD OF REGENTS OF T...

1. A method of treating oral cancer comprising administering to a patient in need thereof a therapeutically effective amount of a compound of the formula:wherein:X2 is S;
R7 is unsubstituted phenyl;
R8 is —OH;
y is 2, 3, 4, 5, 6, 7, 8, or 9;
R9 is aralkyl(C?12), wherein the aryl ring is substituted with halogen; and
R10 is hydrogen, alkyl(C?12), or substituted alkyl(C?12);
or a compound of the formula:
or a pharmaceutically acceptable salt or tautomer thereof.

US Pat. No. 10,457,675

HISTONE DEACETYLASE INHIBITORS AND COMPOSITIONS AND METHODS OF USE THEREOF

CHDI Foundation, Inc., N...

1. A method for treating a condition or disorder mediated by at least one histone deacetylase in a patient in need thereof comprising administering to said patient a therapeutically effective amount of a compound of Formula I:or a pharmaceutically acceptable salt thereof,wherein:
R1 is —C(O)NH(OH) or —N(OH)C(O)R9;
R2 is aryl, heteroaryl, or heterocycloalkyl, each of which is optionally substituted with 1 to 3 substituents independently chosen from halo, alkyl, cycloalkyl, haloalkyl, hydroxyl, alkoxy, and nitrile;
A is aryl or heteroaryl;
R3 is chosen from hydrogen, alkyl, halo, —NHSO2R10, C(O)NR11R12, NR11R12, nitrile, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, aralkyl, and heteroaralkyl, each of which is optionally substituted with 1 to 3 substituents independently chosen from halo, alkyl, cycloalkyl, haloalkyl, hydroxyl, alkoxy, haloalkoxy, aryl, heteroaryl, and nitrile, wherein alkyl and alkoxy are optionally substituted with amino, (alkyl)amino or di(alkyl)amino;
R4 is absent or is chosen from hydrogen, alkyl, halo, —NHSO2R10, C(O)NR11R12, NR11R12, nitrile, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, aralkyl, and heteroaralkyl, each of which is optionally substituted with 1 to 3 substituents independently chosen from halo, alkyl, cycloalkyl, haloalkyl, hydroxyl, alkoxy, haloalkoxy, aryl, heteroaryl, and nitrile, wherein alkyl and alkoxy are optionally substituted with amino, (alkyl)amino or di(alkyl)amino;
for each occurrence, R5, R6, R7, and R8 are independently chosen from hydrogen and lower alkyl;
R9 is hydrogen or lower alkyl;
R10 is lower alkyl, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl;
R11 and R12 are independently chosen from hydrogen, lower alkyl, alkoxy, lower haloalkyl and cycloalkyl, wherein alkyl and alkoxy are optionally substituted with amino, (alkyl)amino or di(alkyl)amino, and
m and m? are independently chosen from 0, 1, 2, 3 and 4, provided that 2?(m+m?)?4.

US Pat. No. 10,457,674

CHEMICAL COMPOUNDS

GlaxoSmithKline Intellect...

1. A compound of formula (I):
wherein
R1 is C1-6alkoxy or —N(C1-6alkyl)2;
R2 is hydrogen or C1-6alkyl optionally substituted by —C(O)OC1-6alkyl or —OC(O)C1-6alkyl;
R3, R4, R5 and R6 are each independently selected from hydrogen and halogen;
R7 and R8 are each independently C1-6alkyl, or
R7 and R8, together with the nitrogen atom to which they are attached, are linked to form a 5- or 6-membered heterocyclyl wherein the 5- or 6-membered heterocyclyl optionally contains a further nitrogen atom and is optionally substituted by C3-6cycloalkyl, 4- to 6-membered heterocyclyl containing one or two heteroatoms independently selected from oxygen and nitrogen, or C1-6alkyl wherein the C1-6alkyl is optionally substituted by hydroxy or C1-6alkoxy, or
R7 and R8, together with the nitrogen atom to which they are attached, are linked to form a 5- or 6-membered heterocyclyl wherein the 5- or 6-membered heterocyclyl contains an oxygen atom and is optionally substituted by one or two substituents independently selected from C1-6alkyl; or a salt thereof.

US Pat. No. 10,457,673

HETEROATOM CONTAINING DEOXYURIDINE TRIPHOSPHATASE INHIBITORS

University of Southern Ca...

1. A compound of formula (I):
or a tautomer thereof, including any stereoisomer, enantiomer or diastereoisomer,
or a pharmaceutically acceptable salt and/or a solvate of each thereof, of formula (I):
or a tautomer thereof, or a pharmaceutically acceptable salt of each thereof, wherein

is

Y10is O, S, SO, SO2, NH or NR 15;
R11is hydrogen, halo, R12 or —O—R12, wherein R12 is C1-C6alkyl, C2-C6 alkenyl, or C2-C6 alkynyl optionally substituted with 1-3 hydroxy, fluoro, chloro, and amino substituent, or R11 is C1-C6 alkyl, C2-C6 alkenyl, or C2-C6 alkynyl wherein each alkyl, alkenyl, and alkynyl is optionally substituted with 1-3 hydroxy, fluoro, chloro, and amino substituent;
r is 1, 2, or 3;
R15 is C1-C6 alkyl optionally substituted with 1-3 C1-C6 alkoxy, hydroxy, amino, and oxo groups;
W is a bond or optionally substituted —CH2—;
X is a bond, O, S, NR19, optionally substituted C1-C6 alkylene, optionally substituted C2-C6 alkenylene, or optionally substituted C1-C6 alkynylene group, a divalent optionally substituted C6-C10 aromatic hydrocarbon group, or a divalent optionally substituted saturated or unsaturated C2-C10 heterocyclic or optionally substituted C1-C10 heteroaryl group;
R19 is hydrogen, optionally substituted C1-C6 alkyl or optionally substituted C3-C8 cycloalkyl;
Y is an optionally substituted C1-C10 alkylene which further optionally has a cycloalkylidene structure on one carbon atom, or is optionally substituted C2-C6 alkenylene, or optionally substituted C2-C6 alkynylene group, or Y is -L10-B1-L11-;
L10 and L11 independently are optionally substituted C1-C6 alkylene, optionally substituted C2-C6 alkenylene, or optionally substituted C2-C6 alkynylene group;
B1 is a divalent optionally substituted C1-C10 heteroaryl group;
Z is —SO2NR31R32, —NR3SO2—R4, or R4 wherein R31 and R32 are the same or different and each represents a hydrogen atom, optionally substituted C1-C6 alkyl group optionally substituted with an aryl group;
R3 is hydrogen or optionally substituted C1 -C6 alkyl; and
R4 is optionally substituted C6-C10 aryl, an optionally substituted C2 -C10 heterocyclic group, or an optionally substituted C1-C10 heteroaryl group;
provided that if W is a bond, X cannot be a bond.

US Pat. No. 10,457,672

?-DIKETONES AS WNT/?-CATENIN SIGNALING PATHWAY ACTIVATORS

Samumed, LLC, San Diego,...

1. A compound of Formula IIIb:
or a pharmaceutically acceptable salt thereof,
wherein:
R14 is selected from the group consisting of unsubstituted —C1-6 alkyl, —C1-3 haloalkyl, and CF3;
R15 is selected from the group consisting of unsubstituted —C1-6 alkyl, —C1-3 haloalkyl, and CF3;
each R16 is independently selected at each occurrence from the group consisting of H, unsubstituted —C1-6 alkyl, —CH2OH, —CH2N(R17b)2, —C1-3 haloalkyl, halide, —OR17, CF3, and CN;
each R17 is independently selected from the group consisting of unsubstituted —C1-6 alkyl, —C1-3 haloalkyl, and CF3;
each R17b is independently selected from the group consisting of H and unsubstituted —C1-3 alkyl; and
q is an integer of 1 to 5;
with the proviso that the compound of Formula IIIb is not a compound selected from the group consisting of:

US Pat. No. 10,457,671

CRYSTALLINE FORM OF CANAGLIFLOZIN AND A METHOD OF ITS PREPARATION

Zentiva k.s., Prague (CZ...

US Pat. No. 10,457,670

ISOINDOLINE-1-ONE DERIVATIVES AS CHOLINERGIC MUSCARINIC M1 RECEPTOR POSITIVE ALLOESTERIC MODULATOR ACTIVITY FOR THE TREATMENT OF ALZHEIMERS DISEASE

Takeda Pharmaceutical Com...

1. A method for a treatment of Alzheimer's disease, schizophrenia, cognitive impairment associated with schizophrenia, pain, sleep disorder, Parkinson's disease dementia, Parkinson's disease, or dementia with Lewy bodies, in a mammal, which comprises administering to the mammal an effective amount of a compound represented by formula (I) below:whereinR1 is an optionally substituted 5- or 6-membered cyclic group or an optionally substituted C1-6 alkyl group;
R2 and R3 are the same or different, and each of R2 and R3 independently is a hydrogen atom, a halogen atom, a cyano group, an optionally substituted C1-6 alkyl group, an optionally substituted C1-6 alkoxy group, or an optionally substituted C3-6 cycloalkyl group;
R4 is a halogen atom, a cyano group, an optionally substituted C1-6 alkyl group, an optionally substituted C1-6 alkoxy group, an optionally substituted carbamoyl group, or an optionally substituted 3- to 8-membered cyclic group; and
Ring A is an optionally further substituted 6-membered aromatic ring,or a salt thereof.

US Pat. No. 10,457,669

BENZOLACTAM COMPOUNDS AS PROTEIN KINASE INHIBITORS

OTSUKA PHARMACEUTICAL CO....

1. A compound selected from:(a) a compound having the formula (2):

or a pharmaceutically acceptable salt or tautomer thereof; and
(b) a compound having the formula (5):

or a pharmaceutically acceptable salt or tautomer thereof;whereinn is 1 or 2;Z is selected from C—Rz and N;Rz is selected from hydrogen; halogen; methoxy; and C1-3 alkyl optionally substituted with hydroxy or methoxy;R1 is selected from:-(Alk1)t-Cyc1; wherein t is 0 or 1; and Alk1 is a C1-4 straight chain or branched alkylene group optionally substituted with 1 or 2 hydroxy groups; and
C1-6 acyclic hydrocarbon groups which are unsubstituted or substituted with 1, 2 or 3 substituents R5 selected from hydroxy; oxo; fluorine; and cyano; and wherein 1 or 2 but not all of the carbon atoms of the hydrocarbon group can be replaced by O or N;Cyc1 is a cyclic group selected from (a) 3 to 9 membered non-aromatic monocyclic and bicyclic carbocyclic and heterocyclic groups containing 0, 1, 2, or 3 heteroatom ring members selected from O, N, S, S(O) and S(O)2; (b) 5 to 6 membered monocyclic heteroaryl groups containing 1, 2 or 3 heteroatom ring members of which 1 is N and the others, when present, are selected from O, N and S; and (c) 3 to 7 membered monocyclic carbocyclic groups; wherein each cyclic group (a), (b) and (c) is unsubstituted or substituted with 1, 2 or 3 substituents R6 selected from hydroxy; oxo; fluorine; amino; NH(Hyd1); N(Hyd1)2; O-Hyd1; —C(?O)—Hyd1; —C(?O)—O—Hyd1 and Hyd1; where Hyd1 is a C1-4 non-aromatic hydrocarbon group optionally substituted with one or more substituents selected from fluorine, hydroxyl and methoxy;R2 is selected from hydrogen; halogen; and C1-3 hydrocarbon groups optionally substituted with one or more fluorine atoms;R3 is hydrogen or a group L1-R7;R4 is selected from hydrogen; methoxy; and C1-3 alkyl optionally substituted with hydroxy, amino, mono- or di-C1-2 alkylamino, a cyclic amino group or methoxy; wherein the cyclic amino group is a saturated 4-7 membered heterocyclic group containing a nitrogen ring member and optionally a second heteroatom ring member selected from O, N and S, wherein the cyclic amino group is linked via a nitrogen ring member thereof to the C1-3 alkyl, and wherein the cyclic amino group is optionally substituted with one or two methyl groups;provided that no more than one R4 can be other than hydrogen or methyl;L1 is selected from a bond; Alk2, Alk2-O and Alk2-C(?O) wherein Alk2 is a C1-4 straight chain or branched alkylene group which is optionally substituted with one or more substituents selected from hydroxy, methoxy, amino, methylamino, dimethylamino and fluorine;R7 is selected from:hydrogen;
CO2H;
NR8R9;
a carbocyclic or heterocyclic group having from 3 to 12 ring members, of which 0, 1, 2 or 3 are heteroatom ring members selected from O, N and S and oxidised forms of S, the carbocyclic or heterocyclic group being optionally substituted with one or more substituents R10; and
an acyclic C1-8 hydrocarbon group optionally substituted with one or more substituents selected from hydroxy; oxo; halogen; cyano; carboxy; amino; mono- or di-C1-4 alkylamino; and carbocyclic and heterocyclic groups having from 3 to 12 ring members, of which 0, 1, 2 or 3 are heteroatom ring members selected from O, N and S and oxidised forms of S, the carbocyclic or heterocyclic group being optionally substituted with one or more substituents R10; wherein one or two but not all of the carbon atoms of the acyclic C1-8 hydrocarbon group may optionally be replaced by O, S, SO, SO2 or NR11;R8 is selected from hydrogen and a C1-4 hydrocarbon group, the C1-4 hydrocarbon group being optionally substituted with 1-2 substituents selected from hydroxy, amino, mono-C1-4 alkylamino, di-C1-4 alkylamino, and 4-7 membered saturated heterocyclic rings containing 1-2 heteroatom ring members selected from O and N, wherein the mono-C1-4 alkylamino, di-C1-4 alkylamino, and 4-7 membered saturated heterocyclic rings are each optionally substituted with 1-2 hydroxy or C1-3 alkyl substituents;R9 is selected from:hydrogen;
a carbocyclic or heterocyclic group having from 3 to 12 ring members, of which 0, 1, 2 or 3 are heteroatom ring members selected from O, N and S and oxidised forms of S, the carbocyclic or heterocyclic group being optionally substituted with one or more substituents R10; and
an acyclic C1-8 hydrocarbon group optionally substituted with one or more substituents selected from hydroxy; oxo; halogen; cyano; carboxy; amino; mono- or di-C1-4 alkylamino; and carbocyclic and heterocyclic groups having from 3 to 12 ring members, of which 0, 1, 2 or 3 are heteroatom ring members selected from O, N and S and oxidised forms of S, the carbocyclic or heterocyclic group being optionally substituted with one or more substituents R10; wherein one or two but not all of the carbon atoms of the acyclic C1-8 hydrocarbon group may optionally be replaced by O, S, SO, SO2 or NR11;or NR8R9 forms a heterocyclic group having from 4 to 12 ring members wherein, in addition to the nitrogen atom of NR8R9, the heterocyclic group optionally contains 1 or 2 further heteroatom ring members selected from O, N and S and oxidised forms of S; and wherein the heterocyclic group is optionally substituted with one or more substituents R10;R10 is selected from:halogen; hydroxy; oxo; cyano;
OR12 wherein R12 is C1-6 alkyl or C3-6 cycloalkyl, each being optionally substituted with halogen;
an acyclic C1-8 hydrocarbon group optionally substituted with one or more substituents selected from hydroxy; oxo; halogen; cyano; carboxy; amino; mono- or di-C1-4 alkylamino; and carbocyclic and heterocyclic groups having 3 to 7 ring members of which 0, 1, 2, 3 or 4 are heteroatom ring members selected from N, O and S, wherein the carbocyclic and heterocyclic groups are optionally substituted with one or more substituents R13 selected from hydroxy; halogen; cyano; amino; —NH(Hyd1); —N(Hyd1)2; and —(O)v-Hyd1 where v is 0 or 1; wherein one or two but not all of the carbon atoms of the acyclic C1-8 hydrocarbon group may optionally be replaced by O, S, SO, SO2 or NR11; and
carbocyclic and heterocyclic groups having 3 to 7 ring members of which 0, 1, 2, 3 or 4 are heteroatom ring members selected from N, O and S, wherein the carbocyclic and heterocyclic groups are optionally substituted with one or more substituents R13; andR11 is selected from hydrogen and a C1-4 hydrocarbon group.

US Pat. No. 10,457,667

INDOLIN-2-ONE DERIVATIVES

Hoffmann-La Roche Inc., ...

1. A compound of formula
wherein
A is phenyl or a six membered heteroaryl group, containing one or two N atoms, selected from

or the oxygen atom may form together with two neighboring carbon atoms from the group A an additional fused ring, selected from

R1 is hydrogen, lower alkyl, lower alkyl substituted by halogen or oxetanyl;
R2 is hydrogen, lower alkyl lower alkoxy, halogen or cycloalkyl; and
--- the dotted line is nothing or may be —CH2—;
or a pharmaceutically acceptable salt thereof.

US Pat. No. 10,457,665

1,4-DI-(4-METHYLTHIOPHENYL)-3-PHTALOYLAZETIDINE-2-ONE AND THE DERIVATIVES THEREOF

Universite De Nantes, (F...

7. A method comprising the in vitro use of at least one compound of formula (I) as defined in claim 1, as inverse agonist of the peripheral endocannabinoid CB1 receptors, said method comprising the step of contacting in vitro said peripheral endocannabinoid CB1 receptor with at least one compound of formula (I).

US Pat. No. 10,457,664

QUINAZOLINE DERIVATIVES AS VEGF INHIBITORS

Genzyme Corporation, Cam...

1. A process for the preparation of a quinazoline derivative of formula I
or a salt thereof,
wherein:
m is an integer from 1 to 3;
R1 is halogeno;
x1 is —O—;
R2 is C1-5alkylR3; and
R3 is piperidin-4-yl where the nitrogen atom of the piperidine ring may bear a C1-4alkyl substituent,
which comprises:
(a) reaction of a compound of the formula III:

wherein R2 and X1 are as defined herein and L1 is chloro, with a compound of the formula IV:

wherein R1 and m are as defined herein;
(b)reaction of a compound of the formula V:

wherein m, X1 and R1 are as defined herein with a compound of formula VI:
R2-L1  (VI)wherein R2 is as defined herein, R3 is piperidin-4-yl where the nitrogen atom of the piperidine ring may bear a C1-4alkyl or an alkoxycarbonyl substituent and L1 is as defined herein; or(c) deprotection of a conpound of a compound of the formula IX:

wherein R1, m and X1 are as defined herein, and R4 represents a protected R2 group
wherein R3is piperidin-4-yl where the nitrogen atom of the piperidine ring bears an alkoxycarbonyl substituent; and
optional reaction of the quinazoline derivative of formula I with an acid or base to obtain a pharmaceutically acceptable salt thereof.

US Pat. No. 10,457,663

PYRAZOL-PYRIDINE DERIVATIVES

Hoffmann-La Roche Inc., ...

1. A compound of formula I:whereinR1? is CH3;
R1 is CH3, ethyl, CF3, CH2OH, cyclopropyl or cyano, or
R1? and R1 may form together a 1,1-dioxo-tetrahydro-thiophen-3-yl ring;
R2 is hydrogen, CH3, ethyl, isopropyl, tert-butyl, cyclopropyl, cyclopropyl-methyl or hydroxy-methyl;
R3 is hydrogen, Cl, F, CF3, CH3, isopropyl, methoxy, cyano or cyclopropyl;
R4 is hydrogen, CH3, F or Cl;
or a pharmaceutically acceptable salt or acid addition salt, a racemic mixture, or its corresponding enantiomer and/or optical isomer and/or stereoisomer thereof.

US Pat. No. 10,457,662

SUBSTITUTED AMIDES FOR TREATING AND PREVENTING CANCER

The Regents of the Univer...

2. A pharmaceutical composition comprising a pharmaceutically acceptable carrier and a compound of claim 1, or a pharmaceutically acceptable salt thereof.

US Pat. No. 10,457,660

HETEROATOM CONTAINING CYCLIC DIMERS

Novus International, Inc....

15. A process for forming a polymer comprising repeat units of Formula (XX), the process comprising contacting a plurality of compounds of Formula (II):
with a catalyst to form the polymer comprising repeat units of Formula (XX):

wherein:
R1 is (CR8R)mYR10R11;
R2, R3, R4, R5, R8, and R9 are independently hydrogen or alkyl;
R6 and R10 are alkyl;
R7 and R11 are not present;
Z and Y are independently sulfur, sulfone, sulfoxide, or selenium; and
n and m are integers from 1 to 20.

US Pat. No. 10,457,659

COMPOSITIONS AND METHODS FOR INCREASING PROLIFERATION OF ADULT SALIVARY STEM CELLS

The Board of Trustees of ...

1. A method of increasing proliferation of adult salivary stem cells in an individual having a head and neck cancer and suffering from, or being at risk of suffering from, radiotherapy-related xerostomia, the method comprising:selectively increasing an enzymatic activity of ALDH-3 in adult salivary stem cells in vivo, by administering a therapeutically effective amount of a selective ALDH-3 agonist continuously from 1 week preceding radiation treatment and at least 3 weeks after radiation treatment, wherein said method increases the number of adult salivary stem cells in the individual having the head and neck cancer and suffering from, or being at risk of suffering from, radiotherapy-related xerostomia by at least 25%, and the ALDH3 agonist is a compound having a structure:

or a pharmaceutically acceptable salt thereof.

US Pat. No. 10,457,658

COMPOUNDS FOR OPTICALLY ACTIVE DEVICES

Merck Patent GmbH, Darms...

1. An optically active intraocular lens article, which comprises a compound of formula (I)
wherein
a is 0 or 1;
a? is 0 or 1;
R1, R2 and R3 are at each occurrence independently selected from the group consisting of H, F, Cl, Br, I, alkyl having from 1 to 20 carbon atoms, partially or completely halogenated alkyl having from 1 to 20 carbon atoms, aryl and heteroaryl;
one of R4 and R5 is a group of formula (II)

and the other of R4 and R5 is selected from the group consisting of H, F, Cl, Br, I, alkyl having from 1 to 20 carbon atoms, partially or completely halogenated alkyl having from 1 to 20 carbon atoms, aryl, heteroaryl, and R6-Sp-[X1]a*;
* each indicate the location of the linkage of the group containing the * to the rest of the compound,
R6 is a carbyl group for a?=1 and for a?=0 is selected from the group consisting of H, F, Cl, Br, I, alkyl having from 1 to 20 carbon atoms, partially or completely halogenated alkyl having from 1 to 20 carbon atoms, aryl and heteroaryl;
Sp is selected from the group consisting of alkanediyl, alkenediyl and alkyndiyl having at least 10 carbon atoms and at most 20 carbon atoms;
X1 and X2 are independently of each other selected from the group consisting of O, S and N—R17;
X3 is O or S;
R10, R11, R12, R13 and R14 are at each occurrence independently of each other selected from the group consisting of H, F, Cl, Br, I, R6-Sp-[X1]a*, alkyl having from 1 to 20 carbon atoms, partially or completely halogenated alkyl having from 1 to 20 carbon atoms, aryl and heteroaryl, provided that at least one of R10, R11, R12, R13 and R14 is R15;
R15 is at each occurrence independently selected from the group consisting of alkyl having from 1 to 20 carbon atoms, partially or completely halogenated alkyl having from 1 to 20 carbon atoms, alkoxy having from 1 to 20 carbon atoms, partially or completely halogenated alkoxy having from 1 to 20 carbon atoms, thioalkyl having from 1 to 20 carbon atoms, and partially or completely halogenated thioalkyl having from 1 to 20 carbon atoms; and
R17 is at each occurrence independently selected from the group consisting of H, F, Cl, Br, I, alkyl having from 1 to 20 carbon atoms, partially or completely halogenated alkyl having from 1 to 20 carbon atoms, aryl and heteroaryl,
provided that the compound of formula (I) comprises one group R6-Sp-[X1]a-*.

US Pat. No. 10,457,656

CONVERSION OF BIOMASS

XYLECO, Inc., Wakefield,...

1. A method for processing biomass, the method comprising:irradiating biomass to reduce the recalcitrance of the biomass;
saccharifying the irradiated biomass with one or more enzymes to produce a first sugar composition comprising xylose and glucose;
fermenting the first sugar composition to produce a second sugar composition comprising xylose and glucose, wherein the concentration of xylose in the second sugar composition is increased relative to the first sugar composition;
isolating the xylose from the second sugar composition;
converting the isolated xylose to furfural; and
converting the furfural to methyltetrahydrofuran.

US Pat. No. 10,457,655

COMPOUNDS AND COMPOSITIONS FOR INHIBITION OF FASN

FORMA THERAPEUTICS, INC.,...

1. A compound of formula (I):
or a pharmaceutically acceptable salt thereof,
wherein:
R1 is selected from the group consisting of:

L is

m is 1, 2, or 3;
n is 0, 1, 2, or 3;
A and B are independently O or S;
Ar1 is
or a 6-10 membered monocyclic or bicyclic aryl, heteroaryl or heterocycloalkyl, wherein (i) said 6-10 membered monocyclic or bicyclic heteroaryl or heterocycloalkyl have 1, 2, 3, or 4 heteroatoms which are independently selected from N, S or O, and (ii) each of saidor 6-10 membered monocyclic or bicyclic aryl, heteroaryl, or heterocycloalkyl is either unsubstituted or optionally independently substituted with 1 or more substituents which can be the same or different and are independently selected from the group consisting of halo, alkyl, —CHzF3-z, cyano, hydroxyl, hydroxylalkyl, amino, aminoalkyl-, (amino)alkoxy-, —CONH2, —C(O)NH(alkyl), —C(O)N(alkyl)2, —C(O)NH(aryl), —C(O)N(aryl)2, —OCHzF3-z, -alkyl, -alkenyl, -alkynyl, -alkoxy or (alkoxyalkyl)amino-, —N(Rc)—C(O)-alkyl, —N(Rc)—C(O)-aryl, -cycloalkyl, -heterocycloalkyl, -aryl, and -heteroaryl;R2 is a 4-15 membered monocyclic, bicyclic, or tricyclic aryl, heteroaryl, cycloalkyl, or heterocycloalkyl, (i) the 4-15 membered monocyclic, bicyclic, or tricyclic heteroaryl or heterocycloalkyl has 1, 2, 3, 4, 5, 6, 7, or 8 heteroatoms that are independently selected from N, S or O, and (ii) wherein each of said aryl, heteroaryl, cycloalkyl, and heterocycloalkyl is either unsubstituted or optionally substituted with 1 or more substituents which can be the same or different and are independently selected from the group consisting of halo, cyano, hydroxyl, hydroxyl-alkyl-, hydroxylcycloalkyl-, hydroxyl-heterocycloalkyl-, hydroxyl-aryl-, hydroxyl-heteroaryl-, amino, aminoalkyl, (amino)alkoxy-, —CONH2, —C(O)NH(alkyl), —C(O)N(alkyl)2, —C(O)NH(aryl), —C(O)N(aryl)2, —CHzF3-z, —OCHzF3-z, -alkyl, alkoxy-, -alkenyl, -alkynyl, aryloxy-, (alkoxyalkyl)amino-, -cycloalkyl, -heterocycloalkyl, (heterocycloalkyl)alkyl-, -aryl, -heteroaryl, —O(alkyl), —O(cycloalkyl), —O(heterocycloalkyl), —O(aryl), —O(heteroaryl), ONH2, —C(O)NH(alkyl), —C(O)N(aryl)2, —C(O)NH(cycloalkyl), —NH(CO)cycloalkyl, —NH(SO2), —NH(SO2)alkyl, —NH(SO2)aryl, —NH(SO2)heteroaryl, —N(SO2)cycloalkyl, —C(O)N(alkyl)2, (aryl)alkyl-, -heteroaryl, (heteroaryl)alkyl-, —S(O)2-alkyl, —S(O)2-aryl, —S(O)2-cycloalkyl, —C(O)N(alkyl)2, —C(O)alkyl, —NH—C(O)-alkyl, —NH—C(O)-cycloalkyl, NH—C(O)-heterocycloalkyl, NH—C(O)-heterocycloalkyl-Rd, —NH—C(O)—Rd—(O)alkyl, —NH—C(O)-aryl, —NH—C(O)—NH-alkyl, NH—C(O)—NH-cycloalkyl, NH2(CO)cycloalkyl-, NH—C(O)—NH-aryl, —NH—C(O)—O-alkyl, NH—C(O)—NH-cycloalkyl, —NH—C(O)—O-cycloalkyl, —NH(Rd)—C(O)-alkyl, —NH(Rd)—C(O)-aryl, —NH(Rd)—S(O2)cycloalkyl, —S(O2)NH2, —S(O2)NH(alkyl), —S(O2)N(Rd)cycloalkyl, —S(O2)N(alkyl)2, —C(O)N(H)(alkyl), —C(O)N(Rd)(cycloalkyl), methylenedioxy, —CHzF3-z, —OCHzF3-z, and -alkoxy;
Rb is H;
each Rc is independently H, halo, C1-C4 alkyl, or C3-C4 cycloalkyl;
each Rd is independently H, halo, C1-C4 alkyl, or C3-C4 cycloalkyl;
and z is 0, 1 or 2;
further wherein:
(i) when R2 is a substituted or unsubstituted form of
Ar1 is not a substituted or unsubstituted form of
(ii) when R1 is
A and B are each independently O, m is 2, n is 1, Ar1 isand R2 issubstituted with alkyl, then the compound of Formula (I) is not the compound

US Pat. No. 10,457,654

THERAPEUTIC COMPOUNDS AND METHODS OF USE THEREOF

GENENTECH, INC., South S...

1. A compound of Formula I:
or a pharmaceutically acceptable salt thereof, wherein:
R1, R2, R3, and R4 are each independently selected from hydrogen, C1-C6 alkyl, cyano, C3-C6 cycloalkyl, hydroxy, C1-C6 alkoxy, nitro, and halo, wherein any C1-C6 alkyl, and C3-C6 cycloalkyl is optionally substituted with one or more groups independently selected from halo, cyano, hydroxy, C1-C6 alkoxy, C1-C6 haloalkoxy, C3-C6 cycloalkyl, and phenyl; and Z is selected from —N(R5)—, —O—, —S—, —S(O)—,and —S(O)2—;
or
R1, R2, and R3 are each independently selected from hydrogen, C1-C6 alkyl, cyano, halo, and C1-C6 haloalkyl; and R4 and Z together with the benzene ring to which they are both attached form a 9- or 10-membered heterobicycle;
Het is 5- or 6-membered heteroaryl optionally substituted with one to three substituents each independently selected from C1-C6 alkyl, cyano, halo, and C1-C6 haloalkyl;
X is selected from —N(R6)2 and —N(R7)3+?W and amine oxides thereof;
Y1 is —C(R8)2—; and Y2 is selected from —(C(R8)2)n —, —N(R9)—, —O —, —C(R8)2—N(R9)—, —N(R9)—C(R8)2—, —C(R8)2—O—, and —O—C(R8)2—;
or
Y1 is selected from —N(R9)—and —O—; and Y2 is —(C(R8)2) n—;
n is selected from 0, 1, and 2;
Y3 and Y6 are each —C(R8)2—;
Y4 and Y5 are each —C(R8)—;
R5 is selected from hydrogen, C1-C6 alkyl, and C3-C6 cycloalkyl;
each R6 is independently selected from hydrogen, C1-C6 alkyl, C3-C6 cycloalkyl, C1-C6 alkanoyl, 4-7 membered heterocycle, 5-6 membered heteroaryl, and C6-C12 aryl, wherein any C1-C6 alkyl, C3-C6 cycloalkyl, C1-C6 alkanoyl, 4-7 membered heterocycle, 5-6 membered heteroaryl, and C6-C12 aryl is optionally substituted with one or more groups independently selected from deuterium, halo, cyano, hydroxy, C1-C6 alkyl, C1-C6 alkoxy, C1-C6 alkanoyl, C1-C6 haloalkyl, C1-C6 haloalkoxy, C3-C6 cycloalkyl, C3-C6 halocycloalkyl, —NRaRb, —C(?O) NRaRbRc, and phenyl, wherein any C1-C6 alkyl, C1-C6 alkoxy, and C1-C6 alkanoyl is optionally substituted with C3-C6 cycloalkyl; or two R6 groups together with the nitrogen to which they are both attached form a 4- to 10-membered heterocycle that is optionally substituted with one or more groups independently selected from deuterium, halo, cyano, hydroxy, C1-C6 alkyl, and C3-C6 cycloalkyl, which C1-C6 alkyl, and C3-C6 cycloalkyl is optionally substituted with one or more groups independently selected from hydroxy and halo;
each R7 is independently selected from C1-C6 alkyl; or two R7 groups together with the nitrogen to which they are both attached form a 4- to 7-membered heterocycle;
each R8 is independently selected from hydrogen, C1-C6 alkyl, C1-C6 haloalkyl, C3-C6 cycloalkyl, benzyl, 5-15 membered heteroaryl, C1-C6 alkoxy, C1-C6 haloalkoxy, C3-C6 cycloalkoxy, hydroxy, halo, cyano, and -L-C6-C12 aryl;
wherein each C3-C6 cycloalkyl, -L-C6-C12 aryl, benzyl, 5-15 membered heteroaryl, and C1-C6 alkoxy, is optionally substituted with one to three substituents Rx each independently selected from C1-C6 alkyl, C3-C6 cycloalkyl, C1-C6 alkoxy, C1-C6 haloalkoxy, cyano, halo, hydroxy, C3-C6 cycloalkoxy, C3-C6 halocycloalkyl, —S(C1-C6 alkyl), —S(O)(C1-C6 alkyl), —S(O)2(C1-C6 alkyl), —NH2 —NH(C1-C6 alkyl), —N(C1-C6 alkyl)2, 4-6 membered heterocycle, and C1-C6 haloalkyl or two R8 that are on adjacent carbons taken together form a double bond; and R9 is selected from hydrogen, C1-C6 alkyl and C6-C12 aryl, which C6-C12 aryl is optionally substituted with one to three substituents each independently selected from C1-C6 alkyl, C3-C6 cycloalkyl, C1-C6 alkoxy, C1-C6 haloalkoxy, cyano, halo, and C1-C6 haloalkyl; or one R8 or R9 taken together with another R8 or R9 and the atoms to which they are attached form a 3-8 membered fused, bridged or spirocyclic ring, which 3-8 membered ring is optionally substituted with one to three substituents each independently selected from C1-C6 alkyl, C1-C6 alkoxy, cyano, halo, and C1-C6 haloalkyl; and L is selected from a bond, —O—, —S—, —S(O)—, and —S(O)2—;
each Ra and Rb is independently selected from the group consisting of hydrogen, C1-C6 alkyl, and C1-C6 alkanoyl;
each Rc is independently selected from 4-7 membered heterocycle that is optionally substituted with one or more groups independently selected from halo, C1-C6 alkyl, and C1-C6 haloalkyl; and
W?is a counterion.

US Pat. No. 10,457,653

ADENYLYL CYCLASE INHIBITORS FOR CHRONIC PAIN AND OPIOID DEPENDENCE

Purdue Research Foundatio...

1. A compound having a formula
or a pharmaceutically acceptable salt thereof, wherein
R1 is an alkyl, alkenyl, alkynyl, heteroalkyl, heteroalkenyl, heteroalkynyl, cycloalkyl, heterocyclyl, or an optionally substituted aryl, arylalkyl, or arylalkenyl;
R2 represents five substituents independently selected from the group consisting of hydrogen, halo, hydroxy, amino, nitro, cyano, thio, alkyl, alkenyl, alkynyl, heteroalkyl, heteroalkenyl, heteroalkynyl, cycloalkyl, heterocyclyl, alkoxyl, alkylamino, alkylthio, haloalkyl, alkylsulfide, sulphonyl, sulfonamide, alkylsulfonamide, or an optionally substituted aryl, arylalkyl, or arylalkenyl; or any two adjacent substituents that are taken together with the attached carbons to form an optionally substituted cycle or heterocycle and each of other substituents is defined as above; and
wherein said compound is selected from the group consisting of

US Pat. No. 10,457,652

3-ALKYL-4-AMIDO-BICYCLIC [4,5,0] HYDROXAMIC ACIDS AS HDAC INHIBITORS

FORMA Therapeutics, Inc.,...

1. A compound of Formula I:
or a pharmaceutically acceptable salt thereof, wherein:
X1 is NR3;
X2 is C?O, and X4 is CR1R2;
X3 is CR1?R2;
Y1 and Y4 are not bound to —C(O)NHOH and are each CR1;
Y2 and Y3 are CR1 when not bonded to —C(O)NHOH and Y2 and Y3 are C when bonded to —C(O)NHOH;
L is selected from the group consisting of —C(O)—, —C(O)(CR1R2)m—, and —C(O)(CR1R2)mO—, wherein L is bound to the ring nitrogen through the carbonyl group;
R is independently selected from the group consisting of —H, —C1-C6 alkyl, —C2-C6 alkenyl, —C4-C8 cycloalkenyl, —C2-C6 alkynyl, —C3-C8 cycloalkyl, —C5-C12 spirocyclyl, heterocyclyl, spiroheterocyclyl, aryl, and heteroaryl containing 1-5 heteroatoms selected from the group consisting of N, S, P, and O, wherein each alkyl, alkenyl, cycloalkenyl, alkynyl, cycloalkyl, spirocyclyl, heterocyclyl, spiroheterocyclyl, aryl, or heteroaryl is optionally substituted with one or more substituents selected from the group consisting of —OH, halogen, oxo, —NO2, —CN, —R1, —R2, —OR3, —NHR3, —NR3R4, —S(O)2NR3R4, —S(O)2R1, —C(O)R1, —CO2R1, —NR3S(O)2R1, —S(O)R1, —S(O)NR3R4, —NR3S(O)R1, heterocyclyl, aryl, and heteroaryl containing 1-5 heteroatoms selected from the group consisting of N, S, P, and O, with the proviso that R is not bound to L via a nitrogen atom;
R1 and R2 are independently, at each occurrence, selected from the group consisting of —H, —R3, —R4, —C1-C6 alkyl, —C2-C6 alkenyl, —C3-C8 cycloalkenyl, —C2-C6 alkynyl, —C3-C8 cycloalkyl, heterocyclyl, aryl, heteroaryl containing 1-5 heteroatoms selected from the group consisting of N, S, P, and O, —OH, halogen, —NO2, —CN, —NHC1-C6 alkyl, —N(C1-C6 alkyl)2, —S(O)2N(C1-C6 alkyl)2, —N(C1-C6 alkyl)S(O)2R5, —S(O)2(C1-C6 alkyl), —(C1-C6 alkyl)S(O)2R5, —C(O)C1-C6 alkyl, —CO2C1-C6 alkyl, —N(C1-C6 alkyl)S(O)2C1-C6 alkyl, and —(CHR5)nNR3R4, wherein each alkyl, alkenyl, cycloalkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl is optionally substituted with one or more substituents selected from the group consisting of —OH, halogen, —NO2, oxo, —CN, —R5, —OR3, —NHR3, —NR3R4, —S(O)2N(R3)2, —S(O)2R5, —C(O)R5, —CO2R5, —NR3S(O)2R5, —S(O)R5, —S(O)NR3R4, —NR3S(O)R5, heterocyclyl, aryl, and heteroaryl containing 1-5 heteroatoms selected from the group consisting of N, S, P, and O;
R1? and R2? are independently, at each occurrence, selected from the group consisting of —H, —C1-C6 alkyl, —C2-C6 alkenyl, —C3-C8 cycloalkenyl, —C2-C6 alkynyl, —C3-C8 cycloalkyl, heterocyclyl, —OH, halogen, —NO2, —CN, —NHC1-C6 alkyl, —N(C1-C6 alkyl)2, —S(O)2N(C1-C6 alkyl)2, —N(C1-C6 alkyl)S(O)2R5, —S(O)2(C1-C6 alkyl), —(C1-C6 alkyl)S(O)2R5, —C(O)C1-C6 alkyl, —CO2C1-C6 alkyl, —N(C1-C6 alkyl)S(O)2C1-C6 alkyl, and —(CHR5)NR3R4, wherein each alkyl, alkenyl, cycloalkenyl, alkynyl, cycloalkyl, or heterocyclyl is optionally substituted with one or more substituents selected from the group consisting of —OH, halogen, —NO2, oxo, —CN, —R5, —OR3, —NHR3, —NR3R4, —S(O)2N(R3)2, —S(O)2R5, —C(O)R5, —CO2R5, —NR3S(O)2R5, —S(O)R5, —S(O)NR3R4, —NR3S(O)R5, heterocyclyl, aryl, and heteroaryl containing 1-5 heteroatoms selected from the group consisting of N, S, P, and O;
R3 and R4 are independently, at each occurrence, selected from the group consisting of —H, —C1-C6 alkyl, —C2-C6 alkenyl, —C3-C8 cycloalkenyl, —C2-C6 alkynyl, —C3-C8 cycloalkyl, heterocyclyl, aryl, heteroaryl containing 1-5 heteroatoms selected from the group consisting of N, S, P, and O, —S(O)2N(C1-C6 alkyl)2, —S(O)2(C1-C6 alkyl), —(C1-C6 alkyl)S(O)2R5, —C(O)C1-C6 alkyl, —CO2C1-C6 alkyl, and —(CHR5)nN(C1-C6 alkyl)2, wherein each alkyl, alkenyl, cycloalkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, and heteroaryl is optionally substituted with one or more substituents selected from the group consisting of —OH, halogen, —NO2, oxo, —CN, —R5, —O(C1-C6 alkyl), —NH(C1-C6 alkyl), —N(C1-C6 alkyl)2, —S(O)2N(C1-C6 alkyl)2, —S(O)2NHC1-C6 alkyl, —C(O)C1-C6 alkyl, —CO2C1-C6 alkyl, —N(C1-C6 alkyl)S(O)2C1-C6 alkyl, —S(O)R5, —S(O)N(C1-C6 alkyl)2, —N(C1-C6 alkyl)S(O)R5, heterocyclyl, aryl, and heteroaryl containing 1-5 heteroatoms selected from the group consisting of N, S, P, and O;
R5 is independently, at each occurrence, selected from the group consisting of —H, —C1-C6 alkyl, —C2-C6 alkenyl, —C3-C8 cycloalkenyl, —C2-C6 alkynyl, —C3-C8 cycloalkyl, heterocyclyl, aryl, heteroaryl containing 1-5 heteroatoms selected from the group consisting of N, S, P, and O, —OH, halogen, —NO2, —CN, —NH(C1-C6 alkyl), —N(C1-C6 alkyl)2, —S(O)2NH(C1-C6 alkyl), —S(O)2N(C1-C6 alkyl)2, —S(O)2C1-C6 alkyl, —C(O)C1-C6 alkyl, —CO2C1-C6 alkyl, —N(C1-C6 alkyl)SO2C1-C6 alkyl, —S(O)(C1-C6 alkyl), —S(O)N(C1-C6 alkyl)2, —N(C1-C6 alkyl)S(O)(C1-C6 alkyl), and —(CH2)nN(C1-C6 alkyl)2;
each n is independently and at each occurrence an integer from 0 to 6; and
each m is independently and at each occurrence an integer from 1 to 6.

US Pat. No. 10,457,651

METHOD FOR PRODUCING 3-ALKYLSULFANYL-2-CHLORO-N-(1-ALKYL-1H-TETRAZOL-5-YL)-4-TRIFLUOROMETHYL-BENZAMIDES

BAYER CROPSCIENCE AKTIENG...

1. Method for preparing 3-alkylsulphanyl-2-chloro-N-(1-alkyl-1H-tetrazol-5-yl)-4-trifluoromethylbenzamides of the general formula (I), comprising reacting 2,3-dichlorobenzotrifluoride (II) with a thiolate (IV) to give a 2-alkysulphanyl-3-chlorobenzotrifluoride (III),b) reacting the 2-alkysulphanyl-3-chlorobenzotrifluoride (III) with an organometallic reagent to give [2-chloro-3-(alkylsulphanyl)-4-(trifluoromethyl) phenyl] metal anion (V) and subsequently with a carboxylating reagent to give 3-alkylsulphanyl-2-chloro-4-trifluoromethylbenzoic acid (VI), and
c) effecting amidation with a 5-amino-1-alkyltetrazole (VII) with an activator in the presence of a base and an acyl transfer reagent to give 3-alkylsulphanyl-2-chloro-N-(1-alkyl-1H-tetrazol-5-yl)-4-trifluoromethylbenzamide (I):

and
d) where the substituents are as defined hereinbelow:
R1 is C1-C4-alkyl or phenyl substituted by s radicals selected from the group consisting of chlorine, fluorine, methoxy and ethoxy,
R2 is C1-C4-alkyl or phenyl substituted by s radicals selected from the group consisting of chlorine, fluorine, methoxy and ethoxy,
M1 is lithium, sodium or potassium,
M2 is Li, ZnX, MgX,
X is chlorine, bromine or iodine,
s is 0, 1, 2 or 3.

US Pat. No. 10,457,650

TRIAZINE COMPOUNDS AS PHOTOSTABILIZING AGENTS

3V Sigma S.P.A., Milan (...

1. Triazine compounds of general formula (I):
wherein:
X is an —O— or —NH— group,
R is a straight, cyclic or branched C1-C18 alkyl group,
and the groups A and B can be, independently of one another:
a group of formula (II)

wherein R1 and R2 can be, independently of one another, H, straight, cyclic or branched C1-C22 alkyls or C1-C18 hydroxyalkyl or C2-C18 alkoxyalkyl, polyalkylene glycols
or a group of formula (III)

wherein Y, independently of the value di X, is a —O— or —NH— group
R3 is a straight, cyclic or branched C1-C18 alkyl group which is the same or different from R
or a group of formula (IV)

wherein Z, independently of the value of X and Y, is an —O— or —NH— group
R4 is a straight, cyclic or branched C1-C18 alkyl group which is the same or different from R and R3.

US Pat. No. 10,457,649

POLYMORPHS OF A MPGES-1 INHIBITING TRIAZOLONE COMPOUND

GLENMARK PHARMACEUTICALS ...

1. A process for the preparation of N-(4-chloro-3-(5-oxo-1-(4-(trifluoromethyl)phenyl)-4,5-dihydro-1H-1,2,4-triazol-3-yl)benzyl)pivalamide (Compound of formula II) or a salt thereof,
which process comprises the steps of:
a) reacting 2-chloro benzoic acid with 2,2,2-trifluoro-N-(hydroxymethyl)acetamide to obtain a substantially pure compound of formula (VI)

b) converting the compound of formula (VI) to a compound of formula (IV)

c) reacting the compound of formula (IV) with oxalyl chloride and a compound of formula (V)

to obtain the compound of formula (III)

and
d) converting the compound of formula (III) to the compound of formula (II),
wherein the N-(4-chloro-3-(5-oxo-1-(4-(trifluoromethyl)phenyl)-4,5-dihydro-1H-1,2,4-triazol-3-yl)benzyl)pivalamide is crystalline, having a characteristic X-ray diffraction pattern comprising peaks expressed in terms of 2?±0.2 at 5.66, 6.55 and 13.05.

US Pat. No. 10,457,648

PROCESS FOR PREPARING (CYCLOPENTYL[D]PYRIMIDIN-4-YL)PIPERAZINE COMPOUNDS

GENENTECH INC., South Sa...

1. A process for preparing a compound of Formula I:
or a salt thereof, the process comprising:
(a) cyclizing a compound of VIb:

or a salt thereof to form a compound of Formula (V);

wherein each X is hydroxyl;
(b) brominating the compound of Formula V or a salt thereof with a brominating agent to form a compound of Formula IV:

or a salt thereof, wherein Y is bromo;
(c) contacting the compound of Formula IV with a piperazine compound having the structure:

or a salt thereof, wherein Lv is a leaving group and R1 is an amino protecting group to form a compound of Formula III:

or a salt thereof; and
(d) contacting the compound of Formula III with a metalating agent to form the compound of Formula I, or a salt thereof; wherein R1 is hydrogen or an amino protecting group.

US Pat. No. 10,457,647

AMINO PYRIMIDINE DERIVATIVES

Novartis AG, Basel (CH)

1. A method of treating a disease which is treated by the modulation of Btk, wherein the method comprising administration of a therapeutically acceptable amount of a compound of formula (I) or a pharmaceutically acceptable salt thereof,
wherein,
R1 is methyl or hydroxymethyl;
R2 is fluoro;
R3 is hydrogen;
R4 is hydrogen;
R5 is fluoro;
or R4 and R5 are attached to each other and stand for —CH2—CH2—, or —CH?CH—;
R6 is H and R7 is cyclopropyl;
R8, R9, R10 and R11 independently from each other stand for H, or C1-C6 alkyl; or any two of R8, R9, R10 and R11 together with the carbon atom to which they are bound may form a 3-6 membered saturated carbocyclic ring;
R and R? are H;
R12 is hydrogen or C1-C6 alkyl optionally substituted by halogen or C1-C6 alkoxy;
or R12 and any one of R8, R9, R, R?, R10 or R11 together with the atoms to which they are bound may form a 4, 5, 6 or 7 membered azacyclic ring, which ring may optionally be substituted by halogen, cyano, hydroxyl, C1-C6 alkyl or C1-C6 alkoxy;
n is 0 or 1; and
R13 is C2-C6 alkenyl optionally substituted by C1-C6 alkyl, C1-C6 alkoxy; or C2-C6 alkynyl optionally substituted by C1-C6 alkyl or C1-C6 alkoxy,
and wherein the disease is selected from chronic autoimmune urticaria.

US Pat. No. 10,457,646

HYDANTOIN DERIVATIVE COMPOUNDS, METHODS OF USE AND METHODS OF TREATMENT

UNIVERSITY OF SOUTH FLORI...

1. A hydantoin derivative compound having the following structure:
wherein D1 is a hydantoin core, D2 is a membrane interacting domain, R1 is a hydrophobic group, R2 is selected from the group consisting of a NH2 group, an aminobutyl group, an aminopentyl group, an aminohexyl group, and an aminopropyl group, and X is a lipid tail.

US Pat. No. 10,457,645

METHOD FOR THE PREPARATION OF 3-FLUOROALKYL-1-METHYLPYRAZOL-4-CARBOXYLIC ACID

CHANGZHOU KEYLAB BIOCHEMI...

1. A method for the preparation of a pesticide, the method comprising preparing a 3-fluoroalkyl-1-methylpyrazol-4-carboxylic acid by the following steps:step 1, fluoroacetyl fluoride derivative shown in Formula I undergoes condensation with dimethyl amino vinyl methyl ketone, as a result, 3-dimethylamino methylene-1,1-difluoro-2,4-pentanedione derivative shown in Formula II is formed:

wherein, R1 is hydrogen, fluorine or chlorine atom; R2 is fluorine or chlorine atom;
step 2, ring closing reaction takes place between said 3-dimethylamino methylene-1,1-difluoro-2,4-pentanedione shown in Formula II and methylhydrazine, in this way, 3-fluoroalkyl-1-methyl-4-acetyl pyrazol derivative shown in Formula III is obtained;

step 3, the said 3-fluoroalkyl-1-methyl-4-acetyl pyrazol derivative shown in Formula III is oxidized in the presence of alkali, and then acidified, in this way, 3-fluoroalkyl-1-methylpyrazol-4-carboxylic acid shown in Formula IV is formed,

and transforming the 3-fluoroalkyl-1-methylpyrazol-4-carboxylic acid into an activated 3-fluoroalkyl-1-methylpyrazol-4-carboxylic acid and reacting the activated 3-fluoroalkyl-1-methylpyrazol-4-carboxylic acid with an amine to obtain the pesticide.

US Pat. No. 10,457,644

PYRAZOL COMPOUNDS AS EAAT3 INHIBITORS

Hoffman-La Roche Inc., L...

1. A compound of formula (I):
wherein
R1? is methyl;
R1 is selected from the group consisting of
i) methyl,
ii) ethyl,
iii) trifluoromethyl
iv) hydroxymethyl,
v) cyclopropyl, and
vi) cyano;
or R1? and R1 together with the carbon atom to which they are attached form 1,1-dioxo-tetrahydro-thiophen-3-yl;
R2 is selected from the group consisting of
i) hydrogen,
ii) methyl,
iii) ethyl,
iv) isopropyl,
v) tert-butyl,
vi) cyclopropyl,
vii) cyclopropylmethyl, and
viii) hydroxymethyl;
R3 is selected from the group consisting of
i) hydrogen,
ii) chloro,
iii) fluoro,
iv) methyl
v) isopropyl,
vi) methoxy,
vii) cyano,
viii) cyclopropyl, and
ix) trifluoromethyl;
R4 is selected from the group consisting of
i) hydrogen,
ii) chloro,
iii) fluoro, and
iv) methyl;
or a pharmaceutically acceptable salt thereof.

US Pat. No. 10,457,643

(?)-HUPERZINE A PROCESSES AND RELATED COMPOSITIONS AND METHODS OF TREATMENT

YALE UNIVERSITY, New Hav...

1. A compound according to the chemical structure:
wherein:
R1 is a methyl group;
R2 and R5 are each independently selected from the group consisting of H and methyl;
R3 at each occurrence is H or methyl;
R4 is selected from the group consisting of H, OH, and Si(CH3)2Ph;
R6 is selected from the group consisting of —C(O)NH2 or CN; and
R7 is methyl; or
a pharmaceutically acceptable salt, enantiomer or diastereomer thereof.

US Pat. No. 10,457,642

211-ASTATINE CONTAINING RADIOTHERAPEUTICS FOR THE TREATMENT OF CANCER

The Trustees of the Unive...

1. A compound of formula (I):wherein:m is 1 or 2;
n is 1 to 10;
R1 to R4 are at the 2-, 3-, 4-, 5-, or 6-position of the benzene ring and, independently, H, C1 to C6 alkyl, C1 to C6 alkoxy, C1 to C6 haloalkyl, halogen, C1 to C6 fluoroalkoxy, C1 to C6 thioalkyl, C1 to C6 thio-haloalkyl, NH2, C1 to C6 aminoalkyl, or —(OCH2CH2)q—F;
q is 2 to 6;
or R1 and R2; R2 and R3; or R3 and R4 together form a 5- or 6-membered benzene ring substituted with H or 1 to 4 R5;
211At is at the 2-, 3-, 4-, 5- or 6-position of the benzene ring; and
R5 is H, C1 to C6 alkyl, C1 to C6 alkoxy, C1 to C6 haloalkyl, halogen, C1 to C6 fluoroalkoxy, C1 to C6 thioalkyl, C1 to C6 thio-haloalkyl, NH2, C1 to C6 aminoalkyl, or —(OCH2CH2)q—F;
with the proviso that two of R1-R4 and 211At do not occupy the same position on said benzene ring;or a pharmaceutically acceptable salt or prodrug thereof.

US Pat. No. 10,457,641

CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS

NEUPHARMA, INC., Foster ...

1. A method of treating a cancer in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a compound of Formula I:
or a pharmaceutically acceptable salt thereof, wherein
Z1 is optionally substituted heteroaryl;
R1, R2, and R3 are independently hydrogen, cyano, halo, hydroxy, azido, nitro, carboxy, sulfinyl, sulfanyl, sulfonyl, optionally substituted alkoxy, optionally substituted aryloxy, optionally substituted heteroaryloxy, optionally substituted heterocycloalkyloxy, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted heterocycloalkyl, optionally substituted amino, optionally substituted acyl, optionally substituted alkoxycarbonyl, optionally substituted aminocarbonyl, optionally substituted aminosulfonyl, or optionally substituted carbamimidoyl;
R4 is hydrogen, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted aryl, or optionally substituted heteroaryl;
R5 is hydroxy, formyl, optionally substituted alkoxy, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted aryl, optionally substituted heteroaryl, —COR7, —CO2R7, —CONR7R8, —C(NR9)NR7R8, or —C(NCN)NR7R8, where R7 is optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted aryl, or optionally substituted heteroaryl; and R8 and R9 are independently hydrogen, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted aryl, or optionally substituted heteroaryl; or R7 and R8 may be joined together with any intervening atoms to form an optionally substituted heterocycloalkyl ring;
or R4 and R5 may be joined together with any intervening atoms to form an optionally substituted heterocycloalkyl ring;
for each occurrence, R6 is independently hydrogen, cyano, halo, hydroxy, carboxy, azido, nitro, sulfonyl, sulfinyl, sulfanyl, optionally substituted alkoxy, optionally substituted aryloxy, optionally substituted heteroaryloxy, optionally substituted heterocycloalkyloxy, optionally substituted alkoxycarbonyl, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted heterocycloalkyl, optionally substituted amino, optionally substituted acyl, optionally substituted aminocarbonyl, optionally substituted aminosulfonyl, or optionally substituted carbaminodoyl; and
m is 0, 1, 2, 3, 4, 5 or 6;
provided that Z1 is not quinoxalin-6-yl,wherein the cancer is skin cancer, lung cancer or colon cancer.

US Pat. No. 10,457,640

SYNTHESIS OF INHIBITORS OF EZH2

Constellation Pharmaceuti...

1. A method for preparing a diastereomerically enriched sulfinamide compound having the formula:
wherein R1 is halo(C1-C6)alkyl and R2 is (C1-C6)alkyl,
the method comprising
reacting an optically active sulfinylimine compound of the formula
with a nucleophile of the formula R2MgX, wherein X is bromide, iodide, or chloride to form the diastereomerically enriched sulfinamide compound.

US Pat. No. 10,457,639

FLUORESCENT REGULATORS OF RASSF1A EXPRESSION AND HUMAN CANCER CELL PROLIFERATION

GEORGETOWN UNIVERSITY, W...

1. A compound that has the structure:

US Pat. No. 10,457,638

SULPHAMOYLPYRROLAMIDE DERIVATIVES AND THE USE THEREOF AS MEDICAMENTS FOR THE TREATMENT OF HEPATITIS B

Janssen Sciences Ireland ...

1. A method of treating Hepatitis B virus infection in a subject in need thereof comprising administering to said subject a therapeutically effective amount of a compound of Formula (ID)
or a stereoisomer or tautomeric form thereof, wherein:
each X is independently CR7;
Ra, Rb and Rc are each independently selected from the group consisting of hydrogen, fluoro, bromo, chloro, —CHF2, —CF2-methyl, —CH2F, —CF3, —OCF3, —CN, C1-C3alkyl and C3-C4cycloalkyl;
Rd is hydrogen or fluoro;
R4 is hydrogen, C1-C3alkyl or C3-C4cycloalkyl;
R5 is hydrogen;
R6 is selected from the group consisting of C2-C6alkyl, C1-C4alkyl-R8 optionally substituted with one or more fluoro, C1-C4alkyl-R9 optionally substituted with one or more fluoro, and a 3-7 membered mono or polycyclic saturated ring optionally containing one or more heteroatoms each independently selected from the group consisting of O, S and N, such 3-7 membered saturated ring or C2-C6alkyl optionally substituted with one or more substituents each independently selected from the group consisting of hydrogen, —OH, fluoro, oxo, R9, R10 and C1-C4alkyl optionally substituted with R10;
R7 is selected from the group consisting of hydrogen, —CN, fluoro, chloro, bromo, —CHF2, —CF2— methyl, —CH2F, —CF3, C1-C3alkyl optionally substituted with methoxy, C2-C3alkenyl and C3-C4cycloalkyl;
R8 is a 3-7 membered saturated ring optionally containing one or more heteroatoms each independently selected from the group consisting of O, S and N, such 3-7 membered saturated ring optionally substituted with one or more C1-C4alkyl optionally substituted with R10;
R9 is selected from the group consisting of C1-C4alkyloxy, —SO2-methyl, —C(?O)—OR11 and —C(?O)—N(R11)2;
R10 is selected from the group consisting of —CN, —OH, fluoro, —CHF2, —CH2F and —CF3;
R11 is hydrogen or C1-C3alkyl;
or a pharmaceutically acceptable salt or a solvate thereof wherein such compound is not

US Pat. No. 10,457,637

BENZENESULFONAMIDE DERIVATIVES AS INVERSE AGONISTS OF RETINOID-RELATED ORPHAN RECEPTOR GAMMA (ROR?(T))

1. A compound of formula (II), or a pharmaceutically acceptable addition salt thereof:
in which:
q denotes zero or a natural integer ranging from 1 to 3,
R1 represents a linear or branched C3-C5 alkyl radical, a C3-C5 cycloalkyl radical, a linear or branched C2-C5 alkenyl radical,
R2 represents a hydrogen atom or a halogen atom, a linear or branched C1-C5 alkyl radical, a linear or branched C2-C4 alkenyl radical, a C1-C4 alkoxy radical, a cyano group —CN; the alkyl, alkenyl and alkoxy radicals optionally being substituted with one or more halogen atoms,
R3 represents a C1-C3 alkyl radical,
R4 represents a hydrogen atom or a (CHR5)n—(Z)0—(CHR?5)p—R6 group,
n, o and p, which are identical or different, denote zero or a natural integer ranging from 1 to 3,
Z represents a divalent group chosen from —CH2—, —NH— and —O—,
R5 and R?5, which are identical or different, represent a hydrogen atom, a methyl radical —CH3, a hydroxyl radical —OH, a C1 hydroxyalkyl radical, a carboxylic radical —COOH,
R6 represents:
a hydrogen or halogen atom,
a heterocyclic radical optionally substituted with one or more halogen atoms, one or more linear or branched C1-C3 alkyl groups, one or more —OH groups, one or more carbonyl functions ?O, one or more linear or branched C1-C4 hydroxyalkyl groups, a pyrrolidine ring, one or more amino groups, one or more —C(?O)R7 groups, one or more S(?O)2R7 groups; wherein the heterocyclic radical is a monocyclic heterocyclic ring having 2-6 carbon atoms and 1 to 4 heteroatoms selected from the group consisting of a sulfur atom, a nitrogen atom, and an oxygen atom; R7 representing a linear or branched C1-C3 alkyl radical, a hydroxyl radical —OH, a linear or branched C1-C4 alkoxy radical, or an amino radical N(R7a)(R7b); with R7a and R7b, which are identical or different, denoting a hydrogen atom, a linear or branched C1-C3 alkyl radical or a cyclopropyl radical,
a C3-C6 cycloalkyl radical optionally substituted with one or more —OH groups;
an aromatic or heteroaromatic radical optionally substituted with one or more halogen atoms, one or more linear or branched C1-C3 alkyl groups optionally substituted with one or more halogen atoms, one or more C1-C3 alkoxy groups, one or more amino groups —NR11R12, one or more —COR11 groups, one or more —OR11 groups, one or more C1-C4 hydroxyalkyl groups, one or more —COOR11 groups, one or more amido —CONR11R12 groups, one or more —SOR11 groups, one or more —SO2R11 groups, one or more —NHCOR11 groups, one or more —NHCOOR11 groups, one or more —SO2NR11R12 groups or one or more —CN groups; wherein the heteroaromatic radical is a 5- or 6-membered monocyclic heteroaromatic ring having 1 to 3 heteroatoms selected from the group consisting of a sulfur atom, a nitrogen atom, and an oxygen atom; R11 and R12, which are identical or different, representing a hydrogen atom or a linear or branched C1-C3 alkyl radical optionally substituted with one or more halogen atoms;
A1 represents a divalent group selected from the group consisting of —NRa, —O—, —S—, —SO—,
—SO2—, —SO(?NH)—, —CH2—, —C?C—, and —CH(Ra)—;
given that:
Ra represents a hydrogen atom, a linear or branched C1-C3 alkyl radical or an acetyl radical —C(?O)CH3,
Rb represents a hydrogen atom, a linear or branched C1-C3 alkyl radical or a cyclopropyl group,
Q1, Q2, Q3, Q4 and Q5 each represent a —CR?2 group,
R?2 represents a hydrogen atom or a linear or branched C1-C5 alkyl radical,
Ra and R3 can form, together with the carbon atoms to which they are attached, a C3-C4 heterocycloalkyl group comprising one sulfur atom and 0 to 1 nitrogen atom, which are optionally substituted with one or more carbonyl functions, one or more C1-C3 alkyl radicals,
when A1 represents —NRa—, then Ra and R4 can form, together with the nitrogen atom to which they are attached, a C2-C10 heterocycloalkyl group optionally comprising 1 to 3 heteroatoms selected from the group consisting of a sulfur atom, a nitrogen atom and an oxygen atom; said heterocycloalkyl group being optionally substituted with at least one radical R14, and
R14 represents a linear or branched C1-C3 alkyl radical, a linear or branched C1-C3 alkoxy radical, a halogen atom, a hydroxyl group —OH, a cyano group —CN, a —CONR15R16 group, a —SO2R16 group, a —COR15 group or an amino group —CONR15R16 group, a —SO2R16 group, a —COR15 group or an amino group —NR15R16; R15 and R16, which are identical or different, representing a hydrogen atom or a linear or branched C1-C3 alkyl radical.

US Pat. No. 10,457,635

PROCESS FOR THE PREPARATION OF A SULFATED DERIVATIVE OF 3,5-DIIODO-O-[3-IODOPHENYL]-L-TYROSINE

BRACCO IMAGING S.p.A., M...

1. A process for the preparation of a sulfated form of a thyroid hormone having formula II (T3S) according to the following reaction:
wherein M is an alkaline metal, comprising the steps of:
a) sulfation of a compound of formula I with chlorosulfonic acid (CSA) in the presence of dimethylacetamide (DMAC), wherein the molar ratio of CSA to the compound of formula I is from 4 to 10, and wherein more than 90% of the compound of formula I is converted to the sulfated derivative;
b) salification of the sulfated derivative to give a compound of formula II, in an aqueous solution of an alkaline metal inorganic salt; and
c) purification of the formula II compound by chromatography on macroreticular aromatic polymeric matrix and elution with a decreasing polarity solution;
wherein the amount of by-products in step a) is lower than 10%.

US Pat. No. 10,457,634

PROCESS FOR THE PRODUCTION OF FORMALDEHYDE

Johnson Matthey Public Li...

10. A process for producing formaldehyde, comprising (a) oxidizing methanol with air in a formaldehyde production unit, thereby producing a formaldehyde-containing stream; and (b) separating said formaldehyde-containing stream into a formaldehyde product stream and a formaldehyde vent gas stream; wherein the formaldehyde vent gas stream, without treatment in a vent gas treatment unit, is passed to one or more stages of a carbon dioxide removal unit operating by either reactive absorption, physical absorption, or pressure-wing adsorption.

US Pat. No. 10,457,633

UREA PRODUCTION WITH CONTROLLED BIURET

STAMICARBON B.V., Sittar...

1. A process for producing urea, the process comprisinga. subjecting ammonia and carbon dioxide to urea forming conditions in a urea synthesis section, thereby producing a urea aqueous stream;
b. sending the urea aqueous stream to a recovery section;
c. subjecting, in the recovery section, the urea aqueous stream to recovery of unreacted ammonia and carbon dioxide from said urea aqueous stream, thereby producing recovered ammonia and carbon dioxide, and a purified urea aqueous stream;
d. recycling said recovered ammonia and carbon dioxide to the synthesis section;
e. sending the purified urea aqueous stream to a concentration section;
f. subjecting, in the concentration section, the purified urea aqueous stream to removal of water, thereby producing a concentrated urea stream;
wherein the residence time of the purified urea aqueous stream in the concentration section is controlled independently of the volume flow per time interval of the purified urea aqueous stream into the concentration section.

US Pat. No. 10,457,632

PRODUCTION METHOD FOR ISOCYANATE COMPOUND

SUMITOMO CHEMICAL COMPANY...

1. A process for producing an isocyanate compound of formula (2):
wherein R1 represents a methyl group, a cyclopropyl group, a chlorine atom, a bromine atom, an ethyl group, or a methoxy group, and R2 represents an alkyl group having one to six carbon atoms, which comprises reacting a compound of formula (1):

wherein R1 and R2 are the same as defined above, with phosgene in the presence of a tertiary amine at 9° C. to 16° C. in one or more solvents selected from the group consisting of toluene and xylene.

US Pat. No. 10,457,631

BIODEGRADABLE AMINO-ESTER NANOMATERIALS FOR NUCLEIC ACID DELIVERY

Ohio State Innovation Fou...

1. A compound of Formula I:
and salts thereof; wherein
each R1 is independently substituted or unsubstituted alkyl; or substituted or unsubstituted alkenyl;
each m is independently 3, 4, 5, 6, 7, 8, 9, or 10.

US Pat. No. 10,457,630

RECLAMATION OF NOBLE PRODUCTS IN A METHOD FOR PRODUCING (METH)ACRYLIC ESTER

Arkema France, Colombes ...

1. A process for recovering unreacted reagents and (meth)acrylic ester products from a heavy (meth)acrylic fraction generated during production of a (meth)acrylic ester by a continuous transesterification reaction of a light C1-C4 alkyl (meth)acrylate with a heavy alcohol in the presence of a catalyst, the heavy fraction comprising at least unreacted reagents and (meth)acrylic ester products and Michael adducts resulting from addition reactions on the (meth)acrylic double bonds and also the catalyst, said process comprising heat treating said heavy fraction at a temperature sufficient to crack the Michael adducts into their constituent components, recovering unreacted reagents and (meth)acrylic ester products in the form of a distillate, and eliminating fluid final residue by means of a pump, wherein the heat treatment is carried out in the presence of at least one antifoulant and viscosity reducing agent which is a dialkyl phthalate, the alkyl chain of which corresponds to that of the light alkyl (meth)acrylate.

US Pat. No. 10,457,628

POLYMERIZABLE COMPOUND, POLYMERIZABLE COMPOSITION, FILM, AND HALF MIRROR FOR DISPLAYING PROJECTION IMAGE

FUJIFILM Corporation, To...

1. A polymerizable compound which is represented by Formula (I):
wherein, in the formula,
R1 indicates a straight-chain or branched alkyl group with 1 to 12 carbon atoms,

the moiety indicated above is a group which is obtained by removing (m+n) hydrogen atoms from benzene,
L1 indicates a single bond, —COO—, or —OCO—,
L2 indicates —COO— or —CONR2—,
Z indicates a single bond, —O—, —NH—, —N(CH3)—, —S—, —COO—, —OCO—, —OCOO—, or—CONR2—,
R2 indicates a hydrogen atom or -Sp-Q,
Sp indicates a straight-chain or branched alkylene group with 1 to 12 carbon atoms which may be substituted with Q, or a linking group which is obtained by substituting any one or more of —CH2— with —O—, —S—, —NH—, —N(Q)-, or —CO— in a straight-chain or branched alkylene group with 1 to 12 carbon atoms which may be substituted with Q,
Q indicates a hydrogen atom or a (meth)acryloyl group,
1 indicates an integer of 1,
m indicates an integer of 1 or 2,
n indicates an integer of 1 to 3,
a plurality of R1's, a plurality of L1's, a plurality of L2's, a plurality of Z's, a plurality of Sp's, and a plurality of Q's may be each the same as or different from each other, and
as —Z-Sp-Q, at least one group where Z is —COO— or —CONR2— and Q is a (meth)acryloyl group is included.

US Pat. No. 10,457,627

PRODRUGS OF GAMMA-HYDROXYBUTYRIC ACID, COMPOSITIONS AND USES THEREOF

XW LABORATORIES INC., Gr...

1. A compound having the chemical structure shown in Formula (IA):
or a pharmaceutically acceptable salt thereof, wherein,
Rg is hydrogen or C1 alkyl; and
Rh and Rf are independently hydrogen, unsubstituted C1-6 alkyl, C1-6 alkoxylcarbonyl, or C3-6 cycloalkoxylcarbonyl.

US Pat. No. 10,457,623

PROCESS FOR THE PREPARATION OF LUBIPROSTONE AND INTERMEDIATES THEREOF

CHIROGATE INTERNATIONAL I...

1. A process for preparing Lubiprostone, comprising the steps of:(1) coupling a cyclopentenone of Formula 1:

wherein R1 is C1-7-alkyl, aryl or aralkyl, each of which is unsubstituted or substituted by C1-4-alkyl, nitro, halogen or alkoxy; and P1 is a protective group for hydroxyl group, with a cuprate derived from a compound of Formula 2a:

wherein P2 is a protective group for hydroxyl group; and X is Cl, Br or I, to form a compound of Formula 3:

wherein R1, P1 and P2 are as defined above;
(2) removing the P2 group and oxidizing the hydroxyl group in ?-side chain to form a compound of Formula 5:

wherein R1 and P1 are as defined above; and
(3) removing the P1 and R1 groups.

US Pat. No. 10,457,621

PROCESS FOR PREPARING ARYL KETONE

ETERNAL MATERIALS CO., LT...

1. A process for preparing a compound of formula (I), (II), (III) or (IV):
said process comprising photo-oxidizing a corresponding compound of formula (V), (VI), (VII) or (VIII):

in the presence of an oxidative system comprising at least one bromide compound, wherein:X1 represents —H, halo, —OH or —OR4;X2 represents —H, —OH, nitro, —N(R4)2, —NHR4, —R4, —OR4, —NR4OH, —ONHR4, Si(R4)3, —OSi(R4)3, —P(R4)2, —P(?O)(OR4)2, —P(?O)(R4)2, or a 5- or 6-membered nitrogen-linked heterocyclyl having one or two heteroatoms selected from N, O or S in which at least one heteroatom is N, with the proviso that when X1 represents —OH, X2 is not —OH or —OR4;R1 and R2 independently represent alkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, amino, amido, or an organic moiety comprising at least one of phosphor, oxygen, nitrogen and silicon, orR1 and R2, together with the carbon atom to which they attach, form a “—C?O” radical or a ring structure;R3 represents H, alkyl, cycloalkyl, aryl, heteroaryl, amino or amido;t represents an integer from 1 to 5;G represents —H, halo, —OH, nitro, —N(R4)2, —NHR4, —R4, —OR4, —NR4OH, —ONHR4, —Si(R4)3, —OSi(R4)3, —P(R4)2, —P(?O)(OR4)2, —P(?O)(R4)2, or a 5- or 6-membered nitrogen-linked heterocyclyl having one or two heteroatoms selected from N, O or S in which at least one heteroatom is N;R4 represents alkyl or aryl;n, m and p independently represent an integer from 2 to 6;L1 represents an n-valent linking group;L2 represents an m-valent linking group; andL3 and L4 represent a p-valent linking group and can be the same or different from each other.

US Pat. No. 10,457,620

SYSTEM FOR PRODUCING PHENOL AND BISPHENOL A INCLUDING REMOVAL UNIT FOR REMOVING METHANOL AND ACETONE

LG CHEM, LTD., Seoul (KR...

1. A system for producing phenol and bisphenol A comprising:a first production unit for producing phenol comprising a decomposition reaction unit and a purification unit;
a second production unit for producing bisphenol A comprising a reaction unit and a concentration unit; and
a removal unit for removing methanol and acetone during the production of phenol and bisphenol A the removal unit comprising:
a removal column comprising an overhead purge part, a bottom recirculation part and a supply part;
wherein the supply part comprises a purification unit discharge part to supply methanol, acetone, and water discharged from the purification unit to the removal column and a concentration unit discharge part to supply phenol, acetone, and water discharged from the concentration unit to the removal column,wherein the supply part is provided to the midsection of the removal column;wherein the overhead purge part removes methanol and acetone from the removal column; and
wherein the bottom recirculation part recirculates phenol, water, and trace amounts of methanol and acetone to the purification unit.

US Pat. No. 10,457,619

RESORCINOL DERIVATIVES FOR COSMETIC USE THEREOF

1. A compound for depigmenting, lightening, and/or bleaching the skin, according to formula (I) below:
wherein:
R1 and R2, which may be identical or different, are chosen from:
a) hydrogen, or
b) a radical COR5, wherein R5 is chosen from a linear C1-C10 or branched C3-C10 alkyl radical;
R3 is chosen from a linear C1-C6 or branched C3-C6 alkyl radical; and
R4 is chosen from:
a) hydrogen,
b) a linear C1-C6 or branched C3-C6 alkyl radical, or
c) a radical COR5,
or a salt thereof, a solvate thereof, an optical isomer thereof, a racemate thereof, or a mixture thereof.

US Pat. No. 10,457,617

PROCESS AND PLANT FOR OBTAINING AN ETHYLENE PRODUCT IN A SUPERCRITICAL STATE

LINDE AKTIENGESELLSCHAFT,...

1. A method for obtaining an ethylene product in a supercritical state, in which a gas mixture containing predominantly or exclusively ethylene and ethane is separated in a distillation column, which is operated at a distillation pressure level of from 5 to 15 bar, into an overhead product containing predominantly or exclusively ethylene and a bottom product containing predominantly or exclusively ethane, the overhead product being withdrawn in the gaseous state from the head of the distillation column and a first portion thereof being liquefied and returned as reflux to the distillation column and a second portion thereof being converted into a supercritical state and being used as the ethylene product, characterised in that, for converting the second portion into the supercritical state, multi-stage compression from the distillation pressure level via a plurality of intermediate pressure levels to a supercritical pressure level is carried out, the second portion in the multi-stage compression being converted predominantly or exclusively directly from the gaseous into the supercritical state.

US Pat. No. 10,457,614

PORTABLE COMPOST RETENTION UNIT WITH REMOVABLE PARTITION

1. A compost retention unit for easy assembly to retain compost or other retained materials when the unit is fully assembled upon a generally flat surface, the compost retention unit comprising:a plurality of interconnected frame structures, the plurality of interconnected frame structures including first and second outer frame structures, a removable partition and a center frame structure; wherein the center frame structure includes a frame and a retention apparatus for retaining the removable partition; wherein the retention apparatus includes a retention member for receiving and retaining the removable partition such that the removable partition can be surrounded on all sides by the frame when it is retained within the frame; wherein the retention member has an opening at a top of the retention member that narrows as it extends away from the top so that the removable partition can tilt for placement into or removal from the center frame structure when engaged within the retention member.

US Pat. No. 10,457,613

ANAEROBIC COLUMN REACTOR FOR BIODEGRADATION OF WASTES AND THE PROCESS THEREOF

1. An anaerobic column reactor for conversion of biodegradable organic matter present in wastewaters and solid wastes into biogas and compost; said reactor consisting essentially of a column of at least four expanded portions (EP), connected to each other by constricted portions (CP), waste feeding and chemicals feeding facility, biogas collection sampling and measurement assembly, slurry/digestate recirculation assembly, with backwash facility;wherein, the waste feeding and chemicals feeding either through inlet pipe (5) with a pump (4) and regulating valve (6) or directly through a funnel with a valve (16); the biogas collection sampling and measurement assembly connected through a pipe (17) with a valve (18); the slurry/digestate recirculation through a pipe with a pump (13) and a valve (14) into the constricted portion; and the bottom opening of the reactor with a valve (15) to impart backwash facility.

US Pat. No. 10,457,609

UREA AMMONIUM NITRATE PRODUCTION

Stamicarbon B.V., Sittar...

11. An apparatus for the production of at least urea and urea ammonium nitrate comprising:(a) a urea production unit comprising a finishing section which is adapted to solidify urea and wherein the finishing section has a gas outlet for a first ammonia-containing off-gas,
(b) an ammonium nitrate section for producing ammonium nitrate in fluid communication with a source of nitric acid and a source of ammonia, having an outlet for aqueous ammonium nitrate solution and an outlet for a second ammonia-containing off-gas,
(c) a urea ammonium nitrate section comprising a unit having an inlet in fluid connection with said outlet for aqueous ammonium nitrate solution and an inlet for receiving urea liquid, for combining said ammonium nitrate solution and said urea liquid, and having an outlet for urea ammonium nitrate solution, and
(d) an off-gas treatment section having a gas inlet in fluid connection with said gas outlet for said first ammonia-containing off-gas , adapted to subject said first off-gas to treatment with an acidic scrubbing liquid,
wherein said off-gas treatment section comprises a gas inlet in fluid communication with said outlet for said second ammonia-containing off-gas.

US Pat. No. 10,457,608

MULTILAYER CERAMIC SUBSTRATE AND ELECTRONIC DEVICE

MURATA MANUFACTURING CO.,...

1. A multilayer ceramic substrate comprising:a surface layer portion including a first layer;
an internal layer portion including a second layer and positioned inward of the surface layer portion and such that the first layer of the surface layer portion is next to the second layer of the internal layer portion; and
a surface layer electrode on a surface of the surface layer portion,
wherein a first thermal expansion coefficient of the first layer is lower than a second thermal expansion coefficient of the second layer,
the first layer and the second layer each contain:
a glass containing 40 weight % to 65 weight % of MO relative to a total weight of the glass, wherein MO is at least one selected from CaO, MgO, SrO, and/or BaO,
35 weight % to 60 weight % of alumina relative to a total weight of the glass and the alumina,
1 weight % to 10 weight % of at least one metal oxide selected from CuO and/or Ag2O relative to a total weight of the glass and the alumina, and
a first amount of the metal oxide in the first layer is more than a second amount of the metal oxide in the second layer.

US Pat. No. 10,457,607

BINDER RESIN COMPOSITION

SUMITOMO SEIKA CHEMICALS ...

1. A binder resin composition comprising an aliphatic polycarbonate resin represented by the formula (1):
wherein each of R1, R2, R3, and R4, which may be identical or different, is a hydrogen atom, an alkyl group having from 1 to 10 carbon atoms, or an aryl group having from 6 to 20 carbon atoms; and m is an integer of from 40 to 23,000, and
an end-capped aliphatic polycarbonate resin represented by the formula (2):

wherein each of R5, R6, R7 and R8, which may be identical or different, is a hydrogen atom, an alkyl group having from 1 to 10 carbon atoms, or an aryl group having from 6 to 20 carbon atoms; each of X and Y, which may be identical or different, is a group having at least one functional group selected from a carboxy group, an ester group, a carbamate group, a silicate group, an isocyanate group, an ether group, an acetal group, and a halogen atom at its end; and n is an integer of from 40 to 23,000.

US Pat. No. 10,457,606

COMPOSITE SINTERED BODY

Sumitomo Electric Industr...

1. A composite sintered body comprising a diamond phase and a non-diamond carbon phase,a non-diamond carbon phase occupancy rate being not lower than 1% and not higher than 30%, the non-diamond carbon phase occupancy rate being a percentage of an area of the non-diamond carbon phase to a total area of one arbitrarily specified cross section of the composite sintered body,
an average particle size of sintered diamond particles forming the diamond phase being not smaller than 50 nm and not larger than 800 nm, and
an average particle size of sintered non-diamond carbon particles forming the non-diamond carbon phase being not smaller than 80 nm and not larger than 1300 nm,whereinthe non-diamond carbon phase is a graphite phase.

US Pat. No. 10,457,599

METHOD AND APPARATUS FOR PRODUCING CEMENT CLINKER

1. Method for chloride bypass gas treatment, comprising:providing a chloride bypass gas flow by drawing at least a fraction of a main exhaust gas flow from a kiln,
a first cooling step of cooling the chloride bypass gas flow by mixing it with a cooling gas to form a mixed chloride bypass gas flow,
dedusting the mixed chloride bypass gas flow, and
a second cooling step of cooling the dedusted-and-mixed chloride bypass gas flow by bringing the dedusted mixed chloride bypass gas flow into thermal communication with at least one heat carrier fluid which is heated as a result of the thermal communication with the dedusted mixed chloride bypass gas flow,
wherein at least a part of the cooled dedusted-and-mixed chloride bypass gas flow obtained after the second cooling step is used as cooling gas in the first cooling step.

US Pat. No. 10,457,598

METHOD OF MANUFACTURING HYDRATED LIME

Mississippi Lime Company,...

1. A method of producing hydrated lime, the method comprising:providing a lime feed comprising calcium oxide and impurities;
milling said lime feed to produce a fine ground lime, wherein said fine ground lime has a particle-size distribution of less than 80% minus 200 mesh;
feeding said fine ground lime into an air classification system;
removing a refined fine lime from said air classification system wherein said refined fine lime is finer than said fine ground lime and has a particle size distribution of greater than 70% minus 200 mesh;
adding water including an additive to said refined fine lime to form damp hydrated lime; and
flash-drying said damp hydrated lime to form dried hydrated lime including said additive.

US Pat. No. 10,457,597

ADHESION PROMOTERS AND GEL-MODIFIERS FOR OLEFIN METATHESIS COMPOSITIONS

Materia, Inc., Pasadena,...

1. A composition, comprising:at least one cyclic olefin;
at least one cyclic olefin metathesis catalyst;
at least one adhesion promoter containing at least one compound containing at least two isocyanate groups and a compound containing a heteroatom-containing functional group and a metathesis-active olefin; and
at least one glass substrate;
wherein the at least one compound containing at least two isocyanate groups is selected from methylene diphenyl diisocyanate (MDI) including any mixture of its three isomers: 2,2?-MDI, 2,4?-MDI and 4,4?-MDI; liquid MDI; solid MDI; polymeric MDI; MDI prepolymer; and liquid carbodiimide modified 4,4?-MDI;
wherein the compound containing a heteroatom-containing functional group and a metathesis-active olefin is selected from 2-hydroxyethyl bicyclo[2.2.1]hept-2-ene-5-carboxylate (HENB), and allyl alcohol; and
wherein the concentration of the adhesion promotor is 0.5 to 4.0 phr, which refers to the weight of adhesion promoter per hundred grams of base resin.

US Pat. No. 10,457,596

OPTICAL SENSOR EMPLOYING A REFRACTIVE INDEX ENGINEERED METAL OXIDE MATERIAL

1. A method of sensing an analyte in an environment in a spatially distributed manner, comprising:providing an optical sensor device in the environment, the optical sensor device including an optical waveguide portion having a core, the core having a first refractive index, and a functional material layer coupled to the optical waveguide portion, the functional material layer being comprised of a material that in a bulk, fully dense form has a natural, non-engineered refractive index that is greater than the first refractive index, the functional material layer being structured to have an engineered second refractive index that is lower than the first refractive index, wherein the functional material layer is an engineered nanostructure material with a plurality of voids formed therein, wherein throughout the functional material layer a porosity of the functional material layer is uniform and a size and a shape of the voids is uniform such that the functional material layer is caused to have the engineered second refractive index and such that light scattering in the optical sensor device is minimized, wherein the functional material layer is a material wherein at least one of the engineered second refractive index of the functional material layer or the optical absorption of the functional material layer will change in response to a parameter relating to the analyte, and wherein the engineered second refractive index of the functional material layer and losses thereof are engineered as to permit interrogation of a desired length of the optical sensor device or a plurality of sensing locations along the optical sensor device using a spatially distributed sensing technique without employing a plurality of in-fiber optic components in the core of the optical sensor device; and
sensing a presence of or measuring the parameter relating to the analyte at a plurality of locations along the optical sensor device using the spatially distributed sensing technique without employing a plurality of in-fiber optic components in the core of the optical sensor device.

US Pat. No. 10,457,595

LASER WELDED GLASS PACKAGES

Corning Incorporated, Co...

1. An apparatus comprising:a first substrate having a first surface;
an inorganic film formed over the first surface of the first substrate;
a second substrate adjacent the first substrate, wherein the inorganic film is between the first substrate and the second substrate; and
a weld formed by the inorganic film at an interface between the first substrate and the adjacent second substrate bonding the first substrate and the second substrate,
wherein the weld is characterized by
and ?tensile laser weld>1 MPawherein ?tensile stress location is the stress present in the first substrate and ?tensile laser weld is the stress present at the interface,
wherein each of the inorganic film, the first substrate and the second substrate are transmissive at approximately 420 nm to approximately 750 nm.

US Pat. No. 10,457,593

GLASS PLATE WITH FILM, TOUCH SENSOR, FILM AND METHOD FOR PRODUCING GLASS PLATE WITH FILM

NIPPON ELECTRIC GLASS CO....

1. A glass sheet with a film, comprising a laminated film, which includes a plurality of films laminated together, formed on a glass sheet,wherein the laminated film includes an inorganic material film, which contains at least a noble metal, formed on a non-reformed surface of the glass sheet, and a plated metal film formed on the inorganic material film, and
wherein the laminated film is black when viewed from a glass sheet side.

US Pat. No. 10,457,592

METHOD FOR PRODUCING A SUBSTRATE COATED WITH A STACK INCLUDING A CONDUCTIVE TRANSPARENT OXIDE FILM

SAINT-GOBAIN GLASS FRANCE...

1. A process for obtaining an item comprising a substrate made of glass or glass ceramic coated on at least one portion of at least one of its faces with a stack of layers comprising no silver layers and comprising at least one layer of a transparent electrically conductive oxide, said process comprising:a step of depositing said stack, in which step said layer of a transparent electrically conductive oxide and a homogenizing layer are deposited, said homogenizing layer being a layer of metal, said homogenizing layer being a last layer of the stack so that said metal at an upper surface of the homogenizing layer is in contact with an outside atmosphere; then
a heat treatment step in which said stack is exposed to radiation.

US Pat. No. 10,457,591

SUBSTRATE PROVIDED WITH A STACK HAVING THERMAL PROPERTIES COMPRISING AT LEAST ONE NICKEL OXIDE LAYER

SAINT-GOBAIN GLASS FRANCE...

1. A transparent substrate provided, on a main face, with a stack of thin layers comprising at least one metallic functional layer having properties of reflection in the infrared region and/or in the solar radiation region, and two antireflective coatings, said antireflective coatings each comprising at least one dielectric layer, said functional layer being positioned between the two antireflective coatings, wherein at least one nickel oxide NixO layer is located under said functional layer in the direction of the substrate and/or above said functional layer, with interposition of at least one layer or of just one layer made of a different material between said nickel oxide NixO layer and said functional layer, and wherein said nickel oxide NixO layer is superstoichiometric in oxygen.

US Pat. No. 10,457,590

SUBSTRATE PROVIDED WITH A STACK HAVING THERMAL PROPERTIES COMPRISING AT LEAST ONE NICKEL OXIDE LAYER

SAINT-GOBAIN GLASS FRANCE...

1. A transparent substrate provided, on a main face, with a stack of thin layers comprising at least one, metallic functional layer having properties of reflection in the infrared region and/or in the solar radiation region, and two antireflective coatings said antireflective coatings each comprising at least one dielectric layer, said functional layer being positioned between the two antireflective coatings, and at least one nickel oxide NixO layer is located on and in contact with the functional layer starting from the substrate, with a physical thickness of said nickel oxide NixO layer of at least 0.3 nm, wherein said nickel oxide NixO layer is superstoichiometric in oxygen.

US Pat. No. 10,457,589

LITHIUM SILICATE DIOPSIDE GLASS CERAMICS

Ivoclar Vivadent AG, Sch...

1. Lithium silicate-diopside glass ceramic which comprises 2.0 to 8.0 wt.-% P2O5 and comprises lithium silicate as main crystal phase and diopside as further crystal phase.

US Pat. No. 10,457,588

LEAD-THROUGH OR CONNECTING ELEMENT WITH IMPROVED THERMAL LOADING CAPABILITY

SCHOTT AG, Mainz (DE)

1. A method for producing a lead-through or connecting element, comprising the method steps of:providing an at least partially crystallizable starting material;
providing a carrier body having an interior volume;
arranging at least a portion of the starting material in the interior volume to form an assembly;
heating the assembly until a temperature is reached at which the starting material bears against and fuses to the portion of the carrier body; and
cooling the assembly until the starting material forms at least partially crystallizable glass,
wherein, during the cooling of the assembly, the carrier body subjects the at least partially crystallizable glass to a compressive stress of greater than or equal to zero at a temperature from at least 10° C. to more than 450° C., and
wherein the assembly has an inversion temperature that corresponds to a maximum operating temperature with a deviation of +/?20%, wherein the maximum operating temperature is above 450° C.

US Pat. No. 10,457,587

THIN THERMALLY AND CHEMICALLY STRENGTHENED GLASS-BASED ARTICLES

Corning Incorporated, Co...

1. A chemically strengthened glass-based article comprising:a first surface and a second surface opposing the first surface defining a thickness (t); and
a thermally strengthened region,
wherein the first surface is flat to 100 ?m total indicator run-out (TIR) along any 50 mm or less profile of the first surface,
wherein the glass-based article comprises a glass having a softening temperature, expressed in units of ° C., of Tsoft and an annealing temperature, expressed in units of ° C., of Tanneal, and a surface fictive temperature measured on the first surface of the glass sheet represented by Tfs, when expressed in units of ° C. and a non-dimensional surface fictive temperature parameter ?s given by (Tfs?Tanneal)/(Tsoft?Tanneal), wherein the parameter ?s is in the range of from 0.20 to 0.9.

US Pat. No. 10,457,586

CHEMICALLY-STRENGTHENED THIN GLASS SUBSTRATES WITH MODIFIED CURVATURE AND METHODS OF MANUFACTURE

PGBC INTELLECTUAL HOLDING...

1. A chemically-strengthened thin glass article, which comprises:a chemically-strengthened thin float glass substrate having a varied glass chemical structure which comprises metallic tin ions, host sodium alkali metal ions, invasive potassium alkali al ions originating from a chemical-strengthening ion-exchange, and reversing sodium alkali metal ions originating from a strength-relaxing reverse ion-exchange; wherein,
the glass substrate has opposing major surface regions each having a chemical structure within the varied glass chemical structure and comprising a concentration of larger invasive potassium alkali metal ions from ion-exchange which extend from the surface to a depth of diffusion, a concentration of metallic tin ions from the float process, and wherein in said surface regions the diffusion of invasive potassium alkali metal ions is asymmetrical, such that one major surface region of said surface regions is a treatment-disadvantaged major surface region containing a greater concentration of metallic tin ions in its chemical structure and as compared to an opposing surface region of said surface regions which is treatment-advantaged; and
wherein in at least one non-perimeter area of the thin glass substrate of the chemically-strengthened thin glass article, at least the treatment-advantaged surface region has been subject to strength relaxing reverse ion-exchange: having a net quantity of smaller sodium alkali metal ions from a reverse ion-exchange medium substituted in place of larger potassium alkali metal ions; and
wherein in a depth extending from the surface to 5 ?m, the average ionic radius of the alkali metal ions located in the treatment-disadvantaged surface region is greater than the average ionic radius of the alkali ions located in the directly opposing treatment-advantaged surface region, and
wherein in a depth extending from 5 ?m to the depth of diffusion, the average ionic radius of the alkali metal ions located in the treatment-advantaged surface region is greater than the average ionic radius of the alkali ions located in the directly opposing treatment-disadvantaged surface region; and
wherein in the chemically-strengthened thin glass article, the level of surface compressive stress of a non-perimeter area upon which reverse ion-exchange has been conducted is at least 100 MPa and the depth of compressive stress is at least 10 ?m, and
wherein a net curvature induced by the sum of the volumes of the asymmetric chemical structure pivoting about a central tension region of the strengthened substrate is about zero and characterized as having a depth of bend less than 50 microns over a 50 mm span on a portion of a surface thereof subjected to reverse-ion exchange.

US Pat. No. 10,457,584

ALTERNATIVE ADDITIVES TO ENHANCE SLURRY DEWATERING

Ecolab USA Inc., St. Pau...

1. A method of separating alumina trihydrate crystals from an alumina trihydrate bearing slurry, the method comprising: combining an alkenyl succinic anhydride and water; adding the combination to the slurry; and separating alumina trihydrate crystals from the slurry.

US Pat. No. 10,457,583

METHOD FOR RELIEVING CORROSIVE ENVIRONMENT OF BOILING WATER REACTOR, NUCLEAR POWER PLANT, AND METHOD FOR INJECTING NOBLE METAL WHICH IS CARRIED OUT IN NUCLEAR POWER PLANT

Hitachi-GE Nuclear Energy...

1. A method for relieving a corrosive environment of a boiling water reactor, the method comprising the steps of:heating a sodium hexahydroxoplatinate solution to 190° C. or higher to produce a platinum oxide colloid, then
injecting hydrogen and the platinum oxide colloid into a water line to be supplied into the reactor pressure vessel during power generation of the boiling water nuclear, and
injecting oxygen or hydrogen peroxide in the water line, wherein
a concentration of the injected oxygen or hydrogen peroxide in the water line is stoichiometrically higher than the concentration of the injected hydrogen.

US Pat. No. 10,457,582

SYSTEM AND METHOD FOR WASTEWATER TREATMENT THROUGH CONTROLLING PURIFICATION FUNCTIONS OF MICROORGANISMS BASED ON ACTIVATED SLUDGE PROCESS

1. A method for wastewater treatment through controlled prioritization of microorganism digestion function, comprising:providing a return sludge comprising aerobic microorganisms capable of exhibiting at least one of a reproductive function, by which the microorganisms absorb organic pollutants and multiply using the absorbed pollutants, and a digestive function, by which the microorganisms digest the organic pollutants as a source of energy into water and carbon dioxide, wherein the return sludge is substantially free of the organic pollutants and wherein at least a majority of the microorganisms are in a dormant state when provided;
providing, using a gas generator, at least one reactive gas into the return sludge;
forming a gas-dispersion return sludge by rendering using one of an atomizer or a cavitation pump the at least one reactive gas into ultra-fine bubbles within the return sludge, wherein a portion of the ultra-fine bubbles dissolves within the return sludge, wherein the at least one dissolved reactive gas activates at least a portion of the dormant microorganisms, and wherein the gas-dispersion return sludge is substantially free of the organic pollutants; and
forming a mixed liquor by combining the gas-dispersion return sludge with a wastewater that comprises at least some of the organic pollutants, wherein the activated microorganisms prioritize the digestive function over the reproductive function upon encountering the organic pollutants within the wastewater.

US Pat. No. 10,457,581

MODULE, REACTOR, SYSTEM AND METHOD FOR TREATING WATER

EMEFCY LTD., Caesarea (I...

1. A water treatment module comprising:at least one elongated gas enclosure comprising a gas inlet and two vertical walls, at least one of said two vertical walls comprising a water-impermeable and gas-permeable membrane having a water-facing side and a gas-facing side, the two vertical walls separating between water external to said enclosure and gas within said enclosure, the gas enclosure being in a rolled or folded configuration to thereby define a convoluted horizontal path and one or more water-treatment spaces formed between opposite water facing sides of the enclosure;
a diffuser arrangement comprising gas diffusers comprising gas release openings positioned below the one or more water treatment spaces and configured for introducing a stream of gas into said one or more water treatment spaces; and
a support structure connected to at least a top portion or bottom portion of the enclosure and configured to maintain the enclosure essentially fixed in its intended convoluted horizontal path configuration when submerged in water and to enable air passage from the diffuser arrangement to the water treatment spaces.

US Pat. No. 10,457,580

DEVICE FOR TREATING A BLACK AND ODOROUS WATER BODY WITH A BIONIC PROCESS

Beijing University of Civ...

1. A device for treating a black and odorous water body comprising:(a) a pre-treatment unit for pre-treating the black and odorous water body, wherein the pre-treatment unit comprises a water pump, a water inlet, a water outlet, and barriers with different thicknesses for physically filtering the black and odorous water body, and a biological enzyme is added into the pre-treatment unit;
(b) a tubular purification system which has an intestinal-like structure in communication with the pre-treatment unit, wherein the tubular purification system comprises a water pump, a water inlet, a water outlet and one or more tubular structures, each comprising an outer wall and a folded inner wall which imitates the inner wall of small intestine; villus-like structures which imitate small intestine villi are densely disposed on the folded inner wall; the villus-like structures are capable of providing support for intestinal probiotics; and an aeration unit is disposed at the bottom of the tubular structures, and is able to provide oxygen into the tubular structures;
(c) a microbial fuel cell in communication with the tubular purification system, wherein the microbial fuel cell has two chambers, one comprising a microbial anode and the other comprising an air cathode; a glass fiber membrane is provided between the anode chamber and the cathode chamber as a proton exchange membrane; an external circuit connects the anode with the cathode through a conducting wire; a mixed microflora is attached to the surface of the anode, and can further degrade the organic materials in the water body treated by the tubular purification system under an anaerobic environment in the anode chamber; and the aeration unit disposed at the bottom of the tubular structure of the tubular purification system is capable of providing oxygen for the cathode chamber;
(d) an inclined tube sedimentation tank in communication with the microbial fuel cell, wherein the inclined tube sedimentation tank comprises a water inlet, a honeycomb-like inclined tube sedimentation area, a water collecting tube, a water outlet, a sludge collecting bucket, a perforated sludge discharge tube, and a sludge tank; the water inlet is positioned below the honeycomb-like inclined tube sedimentation area and the water outlet is positioned above the honeycomb-like inclined tube sedimentation area; the honeycomb-like inclined tube sedimentation area comprises a plurality of inclined tube structures; the inclined tube structures are able to accumulate the suspended or solidified materials from the incoming water into a thin sludge layer on the bottom surface of the inclined tube structures; the thin sludge layer slides back to a sludge suspension layer under gravity, and then sinks into the sludge collecting bucket, and is discharged into the sludge tank via the perforated sludge discharge tube; and a supernatant rises to the water collecting tube and is discharged via the water outlet;
(e) one or more solar cell panels;
wherein the energy to be consumed by the device is from the energy generated by the one or more solar cell panels and the microbial fuel cell.

US Pat. No. 10,457,579

REACTOR AND REACTION SYSTEM BASED ON SUPERCRITCAL WATER OXIDATION, AND PHENOLIC WASTEWATER TREATMENT METHOD

GUANGZHOU INSTITUTE OF AD...

1. A reactor based on supercritical water oxidation, comprising an inner shell and an outer shell, wherein the inner shell is coaxially disposed in the outer shell;the inner shell is divided into two portions, namely an upper cylinder and a lower cone; the cylinder comprises an upper segment of imporous pipe (1411) and a lower segment of straight porous pipe (1404); and the cone is a conical porous wall (1407);
the outer shell comprises an upper connection flange, a middle straight pressure-bearing wall (1403) and a lower conical pressure-bearing wall (1409);
a first annular space is formed between the cylindrical portion of the inner shell and the straight pressure-bearing wall (1403) and the connection flange; a second annular space is formed between the conical porous wall (1407) and the conical pressure-bearing wall (1409); a separation ring (1405) is disposed between the first annular space and the second annular space; high-temperature evaporated water injection pipes (1402) are disposed on an upper portion of the straight pressure-bearing wall; low-temperature evaporated water injection pipes (1406) are disposed on an upper portion of the conical pressure-bearing wall (1409); and an outlet pipe (1408) is disposed at a bottom of the conical pressure-bearing wall (1409);
a nozzle pipe (1401) is coaxially disposed on the connection flange, and the nozzle pipe (1401) passes through a top center of the inner shell.

US Pat. No. 10,457,578

AUTOMATED SULFUR BURNER FOR AGRICULTURAL IRRIGATION

1. A system, comprising:a sulfur burner coupled to an irrigation pipe, the sulfur burner including a tank holding sulfurous acid, a variable speed injection pump having an inlet and an outlet, and a conduit that fluidically couples the tank to the inlet of the pump;
an inlet pipe having an inlet and an outlet, the inlet of the inlet pipe coupled to the irrigation pipe at a first joint and the outlet of the inlet pipe coupled to the sulfur burner;
an outlet pipe having an inlet and an outlet, the inlet of the outlet pipe coupled to the outlet of the pump and the outlet of the outlet pipe coupled to the irrigation pipe at a second joint, the second joint downstream of the first joint along the irrigation pipe;
a pH sensor coupled to the irrigation pipe at a measurement location, the measurement location downstream of the second joint along the irrigation pipe; and
an electronic control system;
wherein the electronic control system is electronically and communicatively coupled to the pH sensor to receive data representative of pH measurements taken by the pH sensor from pH sensor;
wherein the sulfur burner includes an electrically-powered hot surface igniter and the electronic control system is electronically and communicatively coupled to the hot surface igniter to provide commands to the hot surface igniter;
wherein the sulfur burner includes an electrically-powered air intake valve and the electronic control system is electronically and communicatively coupled to the air intake valve to provide commands to the air intake valve;
wherein the sulfur burner includes an electrically-powered water intake valve and the electronic control system is electronically and communicatively coupled to the water intake valve to provide commands to the water intake valve;
wherein the sulfur burner includes a pressure transducer to measure a liquid level within the tank, and the electronic control system is electronically and communicatively coupled to the pressure transducer to receive data representative of liquid level measurements taken by the pressure transducer from the pressure transducer; and
wherein the electronic control system is electronically and communicatively coupled to the pump to provide commands to the pump.

US Pat. No. 10,457,577

WASTE SEPARATION DEVICE WITH SEPARATION MAGNETIC FILTER

Airbus Operations S.A.S.,...

1. A device for separating waste, the device comprising:a tank having a closed internal chamber having an opening with a perimeter located in a first horizontal plane,
wherein the device is provided with an inlet opening and an outlet opening that can be connected to a suction system,
wherein the internal chamber of the tank is provided
with a magnetic filter making it possible to attract and retain ferromagnetic waste likely to be entrained by the suction system into the tank;
with a grating placed between the filter and the base of the tank; and
with a fluid discharge system at the level of a base of the internal chamber, and
wherein the inlet opening and the outlet opening are located on a same side of the first horizontal plane and the magnetic filter is arranged on other side of the first horizontal plane.

US Pat. No. 10,457,575

HYDROGEN WATER GENERATOR

FUJI KEIKI CO., LTD., Ku...

1. A hydrogen water generator comprising:a beverage container for storing water;
an electrode portion including five electrodes having anode and cathode electrodes and being arranged in parallel approximately vertically in the beverage container, wherein one of the electrodes is arranged at a center of four of the electrodes arranged to form a square shape as viewed in a horizontal plane while the electrodes having polarization different from the electrode at the center are arranged at two ends of one diagonal line passing through the electrode at the center, and the electrodes having polarization same as the electrode at the center are arranged at two ends of another diagonal line passing through the electrode at the center;
a supporting portion that supports the electrode portion;
a battery that is stored in the supporting portion; and
a controller that controls voltage to be applied to the electrode portion for a predetermined time, the voltage being obtained by boosting battery voltage supplied from the battery,
wherein the controller mutually switches the polarization of the electrodes at the two ends of the one diagonal line, to be different from the polarization at the center and at two ends of the another diagonal line.

US Pat. No. 10,457,574

REVERSE OSMOSIS SYSTEMS WITH BUILT IN PRESSURE REGULATION

Topper Manufacturing Corp...

1. A reverse osmosis filtration system comprising, as a single self-contained assembly:a manifold assembly with a lower side to which parts of the reverse osmosis filtration system are attached, including a product water storage tank, cartridges that contain a reverse osmosis filtration membrane and other filters, and a control valve hydraulically controlling the operation of the reverse osmosis filtration system; and
a raw water pressure regulator contained within the self-contained reverse osmosis filtration system and coupled to the lower side of the manifold assembly, the raw water pressure regulator having a raw water inlet for coupling to a source of raw water and a pressure regulated outlet coupled to the manifold assembly;
the raw water pressure regulator operating independently of the control valve.

US Pat. No. 10,457,573

METHOD AND APPARATUS FOR PROCESSING RADIOACTIVE WASTEWATER

TSINGHUA UNIVERSITY, Bei...

1. A method for processing radioactive wastewater, comprising:treating the radioactive wastewater using a Disc Tube Reverse Osmosis membrane assembly to produce clear water and a concentrate,
wherein said treating step includes:
passing the radioactive wastewater through a first-stage membrane assembly of the Disk Tube Reverse osmosis membrane assembly and a second-stage membrane assembly of the Disk Tube Reverse osmosis membrane assembly in sequence;
obtaining second-stage clear water from the second stage membrane assembly;
entering first-stage concentrated water flowing out of the first-stage membrane assembly into a third-stage membrane assembly of the Disk Tube Reverse osmosis membrane assembly; and
obtaining the concentrate from the third stage membrane assembly;
wherein the method has a decontamination factor of at least 500 and a concentration multiple of at least 25.

US Pat. No. 10,457,572

OIL WATER SEPARATOR

Exactration, LLC, Shephe...

1. A method of separating oil from an oil and water composite fluid with an oil and water separator, comprising the steps of:supporting a tank with a frame, said tank having opposing sidewalls connecting to a first end wall and a second end wall which join a pair of inclined bottom panels converging in the center forming an obtuse angle and said tank including a selected level with a fluid comprising a major amount of water and a minor amount of oil defining a water reservoir;
transporting an oil water composite fluid with a pump from a source to an oil water composite fluid inlet;
evacuating a coalescing chamber in fluid communication with said oil water composite fluid inlet, said coalescing chamber including a drain and an opening;
filling said coalescing chamber to a selected level whereby an overflow of said oil water composite fluid spills over said edge and said top surface of said inclined cover defining a liquid conveyor;
separating a major amount of an oil and a minor amount of said oil water composite fluid from said oil water composite fluid in said coalescing chamber including an inclined cover extending from a top edge of said second end wall inwardly over a selected portion of said coalescing chamber at a selected obtuse angle of up to about 50 degrees, said inclined cover including a top surface and a bottom surface and an edge therebetween extending between said opposing sidewalls and defining a weir;
accumulating said major amount of oil and said minor amount of oil water composite fluid from said liquid conveyor whereby a mechanical oil separation chamber in fluid communication with said coalescing chamber is disposed between said opposing end walls and said coalescing chamber second end wall and a baffle end wall of a concentrate product chamber at a selected depth within said reservoir;
rotating a drum of a in fluid communication with said mechanical oil separation chamber at a selected speed by a motor whereby a concentrate product comprising a lighter density liquid oil removably adheres, absorbs, or adsorbs to a surface of said rotating drum supported by a frame, said drum having a bottom portion in fluid communication with said major amount of oil and said minor amount of oil water composite fluid;
engaging said surface of said rotating drum at a selected angle with a wiper assembly comprising a blade extending across at least a portion of said rotating drum cooperatively removing at least a portion of said concentrate product therefrom;
removing said concentrate product with said wiper assembly in fluid communication with said concentrate product chamber disposed between said opposing side walls and a reservoir end wall and said rotating drum at a selected depth, said baffle end wall extending upward adjacent said rotating drum at a height above the level of the concentrate product and above the level of the major amount of oil and minor amount of oil water composite fluid, said concentrate product chamber including a discharge port for removal of said concentrate product;
purging said concentrate product with a purge oil chamber comprising an inner purge oil chamber baffle extending from said bottom panel of said coalescing chamber between said opposing side walls from a first end wall of said coalescing chamber inwardly and upward a selected distance above the level of the oil water composite fluid and an outer purge oil chamber baffle extending upward from said bottom panel of said tank and between said opposing side walls and spaced apart from said first end wall of said coalescing chamber and said first end wall of said tank a selected distance below the level of the oil water composite fluid;
forming a clean solution chamber disposed at a selected distance above said tank floor panel and said oil purge chamber baffle extending vertically from a bottom of said clean solution chamber; and
providing a clean solution chamber in fluid communication with said oil purge chamber disposed between said opposing side walls above said tank floor adjacent said first tank wall and in fluid communication with an adjustable outlet pipe in fluid communication with a clean water discharge port.

US Pat. No. 10,457,571

MEMBRANE CLEANING AND DESALINATION WITH A MEMBRANE USING ACOUSTIC PRESSURE SHOCK WAVES

SANUWAVE, INC., Suwanee,...

1. A method of using a porous filtration membrane in a fluid comprising generating acoustic pressure shock waves wherein each cycle of an acoustic pressure shock wave includes a compressive phase and a tensile phase and applying the acoustic pressure shock waves through the fluid to the membrane to prevent or dislodge attachment of biological or solid matter in the fluid to the membrane.

US Pat. No. 10,457,570

SYSTEM AND METHOD OF BALLAST WATER TREATMENT WITH CONTINUOUS BIOFOULING CONTROL

1. A ballast water treatment system suitable for ballasting and de-ballasting water on a ship or sea-going vessel, the system comprising:a primary filtration system adapted to remove particles from a ballast water;
at least one biofouling control (BFC) unit;
at least one ultraviolet (UV) disinfection chamber;
wherein the at least one BFC unit comprises a power supply, a generator configured to generate a plurality of electromagnetic waves, and a propagation apparatus configured to propagate the plurality of electromagnetic waves, wherein the at least one BFC unit is adapted to generate and propagate through the ballast water the plurality of electromagnetic waves during a ballasting process for receiving the ballast water into a ballast tank on the ship or sea-going vessel and a de-ballasting process for discharging the ballast water from the ballast tank,
wherein the at least one UV disinfection chamber comprises at least one ultraviolet (UV) lamp adapted to irradiate filtered ballast water exiting the primary filtration system during the ballasting process and the de-ballasting process, wherein the at least one UV disinfection chamber is adapted to be inactivated during a re-circulation process taking place in an absence of both the ballasting process and the de-ballasting process;
a first pipe which fluidly connects the primary filtration system and the at least one UV disinfection chamber; and
a second pipe which fluidly connects the at least one UV disinfection chamber and the ballast tank;
wherein the at least one BFC unit is disposed at at least one of the first pipe and the second pipe,
wherein the ballast water treatment system is adapted such that, during the re-circulation process, holding water in ballast water pipes, including the first and the second pipe, is re-circulated intermittently or continuously through the primary filtration system and the at least one BFC unit, and
wherein the at least one BFC unit is adapted to at least intermittently generate and propagate through the ballast water the plurality of electromagnetic waves having pulsed peak-to-peak voltage, in a range of 12V to 200V, and at least one desired time-varying frequency range, which is within 50 Hz to 2,000,000 Hz, during the re-circulation process to continuously control multiplication of marine organisms in the ballast water and on a plurality of surfaces in contact with the ballast water, wherein the plurality of electromagnetic waves are adapted to produce an avalanche current in the ballast water to kill the marine organisms without requiring an active substance or chemical.

US Pat. No. 10,457,569

APPARATUS, SYSTEM, AND METHODS FOR USING HUMAN ENERGY IN COLLECTING, TRANSPORTING, AND PURIFYING WATER

1. An apparatus for storing, transporting and cleaning water comprising:a rounded barrel shaped, water impermeable container made of material comprising an ultraviolet light stabilized polymer,
the container comprising an interior container surface and exterior container surface,
two opposing container closed ends, the container closed ends each having an internal surface and external surface,
at least one container port and corresponding removable container port cap,
a handle connected to two removable arms rotatably attached to the container at a container axis of rotation to at least one of the two opposing container closed ends;
the container further comprising a removable translucent, water impermeable casing attached to the inner surface of the container closed ends at the container axis of rotation that can be opened,
an electrical box that can be opened, and the casing comprising at least two removable and replaceable tube shaped ultraviolet lights and at least two fixed copper coils inside the casing,
a free falling magnet that oscillates inside each of the at least two fixed copper coils when the container is rotated,
the ultraviolet lights and the at least two copper coils connected to at least one electrical harness inside the casing;
the container further comprising at least three activated carbon fin cartridges releasably fixed to a corresponding fin base and track, the fin base and track fixed to the inner surface of the container closed ends, the fins spaced proportionally around a circumference of the inner surface of the container.

US Pat. No. 10,457,568

METHOD FOR DESALINATION

MURDOCH UNIVERSITY, Natio...

1. A method of removing dissolved elements from a liquid, the method comprising:a) heating the liquid in a first heating step using a first heat source;
b) introducing said heated liquid from the first heating step into a plurality of distillation steps for purifying the liquid heated by the first heating step, each of the plurality of distillation steps comprising at least one evaporation step and at least one condensation step, each of the plurality of distillation steps producing a distillate and a residual concentrate; and
c) a second heating step for heating an additional volume of liquid;
d) introducing heated liquid from the second heating step into a plurality of flashing chambers, each generating a volume of vapor;
wherein at least a portion of the vapor from at least one of the plurality of flashing chambers is introduced into at least one of the plurality of distillation steps through one of a plurality of inputs consisting of a first input and a series of subsequent inputs, the vapor being introduced having a higher temperature than the temperature in the distillation step that is being introduced into.

US Pat. No. 10,457,567

SYSTEMS AND METHODS FOR DISTRIBUTED UTILITIES

DEKA Products Limited Par...

1. A method for monitoring a water purification device comprising:providing a water purification device for converting an available resource to a desired utility, the water purification device characterized by a plurality of operating parameters;
coupling an input sensor for measuring the available resource entering the water purification device;
coupling an output sensor for measuring the amount of desired utility leaving the water purification device;
coupling a local controller to the input and output sensor for concatenating the measured available resource entering and the amount of desired utility leaving the water purification device on the basis of the input and output sensors;
providing a remote controller for modifying the operation of the water purification device based on the concatenated measured available resource entering and desired utility leaving the water purification device;
providing a self-locating device having an output to the remote controller indicative of a geographical location of the water purification device;
providing communication between a telemetry module and the remote controller; and
providing communication between the telemetry module and a monitoring station,
wherein the self-locating device is a global positioning system, and
wherein the remote controller modifies operation of the water purification device based on the geographical location of the water purification device.

US Pat. No. 10,457,566

LOW-DIMENSIONAL HYPERTHIN FES2 NANOSTRUCTURES FOR ELECTROCATALYSIS

UNIVERSITY OF KANSAS, La...

1. An electrode comprising a FeS2 electrocatalytic material, the FeS2 electrocatalytic material comprising FeS2 nanostructures in the form of FeS2 wires, FeS2 discs, or both, wherein the FeS2 wires and the FeS2 discs are hyperthin having a thickness in the range of from about the thickness of a monolayer of FeS2 molecules to about 20 nm, and further wherein the FeS2 nanostructures are polycrystalline comprising a non-pyrite majority crystalline phase.

US Pat. No. 10,457,565

PRODUCTION METHOD FOR HEMATITE FOR IRON PRODUCTION

Sumitomo Metal Mining Co....

1. A method of producing hematite for ironmaking comprising:mixing sulfuric acid and nickel oxide ore to form a slurry;
heating the slurry in a pressure vessel at a temperature of 240° C. to 250° C. wherein nickel is leached from the ore, thereby forming a nickel containing leachate slurry;
adding a neutralizer to the leachate slurry thereby neutralizing any sulfuric acid and forming a neutralized leachate slurry, wherein a reaction of the neutralizer and the sulfuric acid yields a calcium sulfate; and then
separating the neutralized leachate slurry into a leach residue and a leachate, where the leach residue includes iron oxide and calcium sulfate, and where the leachate includes nickel; and then
heating the leach residue that includes iron oxide and calcium sulfate to 600° C. or more and thereby providing hematite having a sulfur grade of less than 1%.

US Pat. No. 10,457,564

AMMONIA PRODUCTION PLANT

Nuovo Pignone Tecnologie ...

1. An ammonia production plant, comprising:a feed gas compression section;
a process air compression section;
a syngas compression section; and
a refrigerant compression section;
wherein at least two of the compression sections are combined to form a combined compression train driven by a single driver.

US Pat. No. 10,457,563

HIGHLY AMINATED SELF-ASSEMBLING FUNCTIONALIZED MESOPOROUS SILICA NANOPARTICLES AND METHOD OF SYNTHESIS

1. A method for self-assembling a mesoporous silica nanoparticle, said method comprising the following stepsa) condensing a silica precursor, a surfactant and a condensation agent in a solvent;
b) adding an organotriethoxysilane;
c) removing said surfactant;
wherein the portion of said organotriethoxysilane to said silica precursor is comprised between 5% and 15%.

US Pat. No. 10,457,562

ANTI-CORROSION SOL-GEL MATERIAL

Trent University, Peterb...

1. A sol-gel material, comprising:a) a first colloidal sol-gel formed from:
i) tetrasilanol, and
ii) a trisilanol compound having an epoxy group;
b) a second colloidal sol-gel formed from:
iii) tetrasilanol, and
iv) a trisilanol compound having a thiol group,wherein the first colloidal sol-gel is cross-linked to the second colloidal sol-gel.

US Pat. No. 10,457,561

LIQUID COMPOSITION FOR FORMING SILICA POROUS FILM AND SILICA POROUS FILM FORMED FROM SUCH LIQUID COMPOSITION

MITSUBISHI MATERIALS CORP...

1. A liquid composition for forming a silica porous film, comprisinga hydrolyzate of tetramethoxysilane or tetraethoxysilane as a silicon alkoxide, and
a silica sol in which fumed silica particles having primary particles having a mean particle diameter of 40 nm or less and secondary particles having a mean particle diameter of 20 nm to 400 nm, that is greater than the mean particle diameter of the primary particles, are dispersed in a liquid medium,
wherein a mass ratio (A/B) between a SiO2 content (A) in the hydrolyzate and a SiO2 content (B) of the silica sol is in a range of 1/99 to 60/40,
the hydrolyzate of tetramethoxysilane or tetraethoxysilane is obtained by a hydrolysis reaction of tetramethoxysilane or tetraethoxysilane in the presence of an acidic catalyst,
a SiO2 concentration of the hydrolyzate is 1% by mass to 20% by mass, and
a SiO2 concentration of the silica sol is 5% by mass to 40% by mass.

US Pat. No. 10,457,560

SYNTHESIS OF MESOPOROUS SILICA SHAPES USING SODIUM SILICATE AS A SILICA SOURCE

Clarkson University, Pot...

1. A method for preparation of nanoporous silica particles, having a self-sealed property, comprising either nanoporous silica spheres, nanoporous silica discoids, or a mixture of nanoporous silica spheres and nanoporous silica discoids, the method comprising the steps of:combining sodium silicate, an aqueous solvent, an acidic catalyst, and a structure directed agent (SDA) into a precursor solution; and
forming said nanoporous silica spheres and/or nanoporous silica discoids via a molecular self-assembly process, wherein each particle is formed by a plurality of hexagonally organized pore channels running along the circumference of the particle axis forming the shape of the particle, wherein the ends of these hexagonally organized pore channels join together, such that the nanoporous particles are self-sealed, the process comprising the step of incubating said precursor solution at a predetermined temperature for a predetermined amount of time in order to obtain said self-sealed nanoporous spheres and/or discoids; and
collecting said nanoporous silica spheres and/or discoids using gravitational precipitation, centrifugation, filtration, dialysis, and/or a combination thereof.

US Pat. No. 10,457,558

METHOD TO PRODUCE URANIUM SILICIDES

Westinghouse Electric Com...

1. A method comprising:forming uranium dioxide;
reacting uranium dioxide with carbon to produce uranium carbide; and,
reacting uranium carbide with a silicon based reactant comprised of a silane, a silicon halide, a siloxane, and combinations thereof, in the presence of excess hydrogen to form a uranium silicide product,
wherein uranium dioxide is formed by a process selected from the group consisting of an ammonium uranyl carbonate process, an ammonium diuranate process, and an integrated dry route process.

US Pat. No. 10,457,557

PROCESS FOR PREPARING GRAPHENE NANOPLATELETS

DIRECTA PLUS S.P.A., Lom...

1. A process for producing graphene nanoplatelets having a C/O ratio ?100:1, comprising the steps of:a) expanding flakes of intercalated graphite having a lateral size of ?500 ?m by exposing said flakes to a temperature from 1300 to 12000° C. for a time of less than 2 seconds and obtaining an expanded graphite,
b) dispersing said expanded graphite in a dispersing medium,
wherein said dispersing medium is water and said dispersion of said expanded graphite is carried out in the absence of a surfactant or in the presence of a surfactant in an amount not higher than 1% by weight of the weight of said expanded graphite, and
said dispersion of said expanded graphite in said dispersing medium is carried out directly after said step of expansion at high temperature by collecting said expanded graphite in said dispersing medium just after its formation:
c) subjecting said expanded graphite obtained from step b) to exfoliation and size reduction treatment by high pressure homogenization in a homogenizer in which the dispersion of said expanded graphite is pumped at a pressure above 35 MPa through one or more microchannels or necks having a transverse section of 500 ?m or less, whereby the particles of said expanded graphite are subjected to shear stresses and are caused to collide at an energy level from 10 to 200 Wh/g, and
d) obtaining a dispersion of said graphene nanoplatelets in said dispersing medium, wherein at least 90% of said graphene nanoplatelets have a lateral size (x, y) from 50 to 50,000 nm and a thickness (z) from 0.34 to 50 nm, the lateral size being greater than the thickness (x,y>z).

US Pat. No. 10,457,556

CARBON NANOSTRUCTURE PREPARATION METHOD, CARBON NANOSTRUCTURE PREPARED BY MEANS OF SAME, AND COMPOSITE MATERIAL COMPRISING SAME

LG CHEM, LTD., Seoul (KR...

1. A method for producing carbon nanostructures, comprising:contacting a catalyst with reactant gases comprising a carbon source in a fluidized bed reactor;
converting the carbon source to carbon nanostructures within the fluidized bed reactor, wherein conversion of the carbon source to the carbon nanostructures is 50% or above;
collecting some of the carbon nanostructures formed within the fluidized bed reactor, wherein some of the carbon nanostructures remain uncollected and are used as fluidic materials in the fluidized bed reactor and wherein a residual rate of the fluidic materials is from 0.4 to 0.7, as calculated by Equation 1:
Residual rate of carbon nanostructures=Volume of remaining carbon nanostructures/(Volume of initially remaining carbon nanostructures+Volume of as-produced carbon nanostructures).  [Equation 1]

US Pat. No. 10,457,555

METHOD FOR MAKING CARBON NANOTUBE ARRAY

Tsinghua University, Bei...

1. A method for making a carbon nanotube array, the method comprising:depositing a catalyst layer on a substrate surface of a growth substrate, to form a composite structure;
placing the composite structure in a chamber;
growing a carbon nanotube array on the substrate surface by supplying a carbon source gas and a protective gas into the chamber and heating the inside of the chamber, containing the composite structure, to a first temperature; and
stopping the supply of the carbon source gas to the chamber and supplying an oxygen containing gas to the chamber and oxidizing the carbon nanotube array at a second temperature, in a range from about 500 degrees Celsius to about 800 degrees Celsius for five to about 20 minutes, wherein a flow rate of the oxygen containing gas ranges from about 300 sccm to 500 sccm.

US Pat. No. 10,457,554

CARBON NANOTUBES AND METHODS OF MAKING CARBON NANOTUBES

KING ABDULLAH UNIVERSITY ...

1. A method for hydrocarbon catalytic decomposition, comprising:heating a catalyst to about 400 to 1000° C. under an inert gas;
flowing a hydrocarbon across the catalyst;
decomposing the hydrocarbon to produce carbon nanotubes (CNTs) having an inner diameter of about 5 to 55 nm; and adjusting a reaction pressure to select the inner diameter of the CNTs;
wherein the reaction pressure is adjusted within a range of about 5 to about 50 bar.

US Pat. No. 10,457,553

BORON NITRIDE MATERIAL AND METHOD OF PREPARATION THEREOF

Nanyang Technological Uni...

1. A method of preparing a boron nitride material, the method comprisingproviding a substrate, wherein the substrate is a metallic substrate or graphene or a substrate having one or more carbon nanotubes, and
sublimating an amine borane complex onto the substrate, the amine borane complex having general formula
R3N.BX3,whereinX at each occurrence is independently selected from the group consisting of hydrogen and a halogen, and R at each occurrence is independently a linear or branched, unsubstituted alkyl with 1 to 20 carbon atoms; and
wherein the sublimating is carried out (i) at a temperature of about 50° C. or less to obtain a boron nitride material consisting essentially of boron nitride, or (ii) at a temperature of greater than about 50° C. and less than about 100° C. to obtain a boron nitride material doped with about 2 wt % to about 5 wt % carbon, or (iii) at a temperature in the range of about 100° C. to about 200° C. to obtain a boron nitride composite comprising one or more domains of boron nitride and carbon.

US Pat. No. 10,457,552

FLOW SENSING OZONE CONVERTER

HAMILTON SUNDSTRAND CORPO...

1. A flow sensing ozone converter, comprising:an inlet housing having an inlet housing first end, an inlet having a constant diameter extending from the inlet housing first end, and an inlet housing second end, the inlet housing defining a first pressure port and varying in diameter between the inlet housing first end and the inlet housing second end;
an outlet housing having an outlet housing first end, an outlet housing second end, and an outlet extending from the outlet housing second end, the outlet housing defining a second pressure port; and
a central housing extending between the inlet housing second end and the outlet housing first end.

US Pat. No. 10,457,551

HEAT AND HYDROGEN GENERATION DEVICE WITH ECU CONTROLLING AIR FEED DEVICE

Toyota Jidosha Kabushiki ...

1. A heat and hydrogen generation device comprising:a burner combustion chamber;
a burner arranged in the burner combustion chamber for performing burner combustion;
a fuel feed device able to control an amount of feed of fuel fed from the burner into the burner combustion chamber;
an air feed device able to control a temperature and amount of feed of air fed from the burner into the burner combustion chamber;
an ignition device for causing the fuel to ignite, a reformer catalyst to which burner combustion gas is fed; and
an electronic control unit,
wherein said air feed device is provided with a heat exchange part for heating the air fed from the burner into the burner combustion chamber by the burner combustion gas, heat and hydrogen being generated by performing the burner combustion, wherein an allowable catalyst temperature enabling heat degradation of said reformer catalyst to be avoided is set in advance,
said electronic control unit is programmed to control said air feed device to lower the temperature of the air fed from said burner into the burner combustion chamber for maintaining the temperature of the reformer catalyst at below the allowable catalyst temperature when the burner combustion is being performed and when the temperature of said reformer catalyst exceeds said allowable catalyst temperature or it is predicted that the temperature of said reformer catalyst will exceed said allowable catalyst temperature, and
when the heat and hydrogen generation device starts to be operated, said electronic control unit is programmed to perform a primary warm-up operation in which the temperature of the reformer catalyst is made to rise by performing burner combustion by a lean air-fuel ratio, and then perform a secondary warm-up operation in which the temperature of the reformer catalyst is made to rise and hydrogen is generated at the reformer catalyst by performing burner combustion by a rich air-fuel ratio.

US Pat. No. 10,457,550

MEMS DEVICES AND METHODS OF FORMING SAME

Taiwan Semiconductor Manu...

1. A method of forming a microelectromechanical systems (MEMS) device comprising:forming a first dielectric layer on a first substrate;
bonding a first wafer to the first dielectric layer;
forming a first set of conductive electrodes over the first wafer;
patterning the first wafer to have a movable element and a static element, the movable element capable of free movement in at least one axis;
forming a first recess in a second substrate;
forming a second set of conductive electrodes over the second substrate, at least one of the second set of conductive electrodes extending laterally into the first recess of the second substrate;
bonding the second substrate to the first substrate using the first and second sets of conductive electrodes, wherein after the bonding, the first recess in the second substrate being interposed between the second substrate and the movable element in a plane orthogonal to a major surface of the first substrate; and
forming a conductive via extending through the second substrate, the conductive via electrically coupled to at least one of the conductive electrodes of the first and second sets of conductive electrodes, the conductive via comprising polysilicon.

US Pat. No. 10,457,549

SEMICONDUCTIVE STRUCTURE AND MANUFACTURING METHOD THEREOF

TAIWAN SEMICONDUCTOR MANF...

1. A semiconductive structure, comprising:a first substrate comprising:
an interconnection layer; and
a first conductor protruding from the interconnection layer;
a second substrate comprising a second conductor bonded to the first conductor;
a first cavity between and sealed by the first substrate and the second substrate, wherein the first cavity has a first cavity pressure; and
a second cavity between and sealed by the first substrate and the second substrate, wherein the second cavity has a second cavity pressure,
wherein the first cavity partially extends through the interconnection layer, and a first surface of the interconnection layer is a sidewall of the first cavity;
the first cavity pressure is less than the second cavity pressure;
a bottommost surface of the second cavity is substantially co-planar with a second surface of the interconnection layer substantially orthogonal to the first surface; and
the second cavity is defined by the second surface of the interconnection layer and a surface of the second substrate, a surface of the first conductor and a surface of the second conductor.

US Pat. No. 10,457,548

INTEGRATING MEMS STRUCTURES WITH INTERCONNECTS AND VIAS

Intel Corporation, Santa...

1. An electronic device comprising:a back end of line (BEOL) structure comprising a beam over a substrate, wherein the beam is clamped by one or more vias; and
a conductive interconnect contact region on and above the beam, the conductive interconnect contact region vertically over one of the one or more vias, wherein the conductive interconnect contact region, the beam and the one of the one or more vias are monolithic and comprise a continuous metal liner along sidewalls of the conductive interconnect contact region, the beam and the one of the one or more vias.

US Pat. No. 10,457,547

MULTI-LAYER, STRESS-ISOLATION PLATFORM FOR A MEMS DIE

DunAn Microstaq, Inc., A...

11. A method of attaching a MEMS pressure sensor die to a base, the method comprising:positioning a first attachment material preform on a base, wherein the first attachment material preform has a single, centrally formed opening therethrough and the base has a single bore defining a pressure port formed therein;
positioning a first platform on the first attachment material preform, the first platform formed from a solid material and having a single, centrally formed bore therethrough;
positioning a second attachment material preform on the first platform, wherein the second attachment material preform has a single, centrally formed opening therethrough;
positioning a MEMS pressure sensor die on the second attachment material preform, the MEMS pressure sensor die having a fluid port formed therein; and
heating the first and second attachment material preform in a re-flow process to attach the MEMS pressure sensor die to the first platform and to attach the first platform to the base;
wherein the first platform, the first attachment material preform, and the second attachment material preform cooperate to define an attachment platform, configured as a multi-layer, stress-isolation platform; and
wherein the centrally formed opening of the first attachment material preform, the centrally formed bore of the first platform, and the centrally formed opening of the second attachment material preform are aligned to define a pressurized fluid flow path between the pressure port formed in the base and the fluid port formed in the MEMS pressure sensor die.

US Pat. No. 10,457,546

MICRO-ELECTRO-MECHANICAL SYSTEM STRUCTURE AND METHOD FOR FORMING THE SAME

UNITED MICROELECTRONICS C...

1. A method for forming a MEMS structure, comprising:forming a sacrificial layer comprising a plurality of pin holes;
forming a lower dielectric film filling in the plurality of the pin holes of the sacrificial layer and on an upper surface of the sacrificial layer;
forming an upper dielectric film on the lower dielectric film;
forming a plurality of through holes passing through the lower dielectric film and the upper dielectric film; and
forming a protective film covering side walls of the upper dielectric film and the lower dielectric film and a film interface between the lower dielectric film and the upper dielectric film, wherein a silicon content of a silicon nitride in the protective film is larger than a silicon content of a silicon nitride in the lower dielectric film and a silicon content of a silicon nitride in the upper dielectric film.

US Pat. No. 10,457,545

MAGNETIC INERTIAL SENSOR ENERGY HARVESTING AND SCAVENGING METHODS, CIRCUITS AND SYSTEMS

STMICROELECTRONICS S.R.L....

1. A magnetic energy harvesting and scavenging circuit, comprising:a first substrate having a first surface and a second surface;
at least one energy harvesting and scavenging coil formed adjacent the first surface;
an electromechanical systems device including a moveable mass extending over the first surface of the first substrate and configured to be displaced relative to the first substrate in three dimensions responsive to an external force applied to the moveable mass, and the movable mass including a magnet support layer and a plurality of permanent magnet segments attached to the magnet support layer, the plurality of permanent magnet segments being magnetically coupled to the at least one energy harvesting and scavenging coil; and
energy harvesting and scavenging circuitry electrically coupled to the at least one energy harvesting and scavenging coil, the energy harvesting and scavenging circuitry configured to generate electrical energy due to magnetic flux variation through the at least one energy harvesting and scavenging coil responsive to movement of the moveable mass.

US Pat. No. 10,457,544

MEMS TRANSDUCER FOR INTERACTING WITH A VOLUME FLOW OF A FLUID AND METHOD FOR MANUFACTURING THE SAME

Fraunhofer-Gesellschaft z...

74. A MEMS transducer for interacting with a volume flow of a fluid, comprising:a substrate comprising a cavity;
an electromechanical transducer connected to the substrate in the cavity and comprising an element deformable along a lateral movement direction, wherein a deformation of the deformable element along the lateral movement direction and the volume flow of the fluid are causally related;
wherein the lateral movement direction extends in-plane with respect to the substrate;
a first and a second electromechanical transducer connected to the substrate and each comprising an element deformable along the lateral movement direction, configured to be deformed along the lateral movement direction, wherein the first electromechanical transducer and the second electromechanical transducer are configured to move towards each other during a first time interval and to move away from each other during a second time interval, wherein a volume of a subcavity between the first electromechanical transducer and the second electromechanical transducer is variable during the first and second time intervals;
wherein a first deformable element of the first electromechanical transducer and a second deformable element of the second electromechanical transducer comprise a bar structure configured to be curved along an axial direction of the bar structure;
wherein the first deformable element is formed to be active and is configured to interact with the volume flow, or a plate element connected to the first deformable element is configured to be rigid is configured to interact with the volume flow.

US Pat. No. 10,457,543

ELECTROSTATIC ACTUATOR AND SWITCH

SONY CORPORATION, Tokyo ...

1. An electrostatic actuator comprising:a base;
a movable electrode including a semiconductor and supported to the base to be displaceable in a first direction;
a fixed electrode including the semiconductor and fixed to the base, the fixed electrode facing the movable electrode in a state of being separated therefrom in the first direction; and
a high-resistance region formed in at least a portion of each of respective facing surfaces of the movable electrode and the fixed electrode, and lower in impurity concentration than a surrounding region thereof.

US Pat. No. 10,457,542

SAFETY STIRRUP FOR HORSEBACK RIDING

TENUTA MONTEMAGNO HORSES ...

1. A safety stirrup for horseback riding comprising:a first semi-arch element having a first end integrally connected to a first portion of a base element of the stirrup and a second end comprising a through hole for mounting a stirrup leather;
a second semi-arch element having an end elastically connected to a second portion of the base element opposed to the first portion, said second semi-arch element being configured to delimit, by said first semi-arch element and said base element, a portion for inserting a rider's foot in the stirrup;
the safety stirrup further comprises a first elastic interposed between the end of the second semi-arch element and the second portion of the base element, said first elastic having an extension direction parallel to a main axis (X) of the base element to allow the bending of the second semi-arch element along said main axis (X) away from the first semi-arch element as a result of the application of a force on the second semi-arch element in such a moving away direction and to elastically return said second semi-arch element to a rest position when said force ends.

US Pat. No. 10,457,541

UNDER-SADDLE AND MANUFACTURING METHOD THEREOF

AMAHORSE TRADING S.r.l., ...

1. An under-saddle comprising:a flexible base defining a pair of base surfaces, the flexible base having a relative thickness between the pair of base surfaces; and
a plurality of separation elements extending from at least one of the base surfaces to distance the flexible base from an opposite abutment surface in contact with the separation elements; wherein:
a first portion of the separation elements are reciprocally distributed such that a pair of the separation elements, together with the at least one of the base surfaces and the opposite abutment surface, define an aeration chamber or duct that is open on at least one side; and
a second portion of the separation elements are symmetrically distributed with respect to the flexible base and extending from each base surface and integrally connected to each other, the second portion of the separation elements defining a plurality of coupled separation elements of the separation elements, each of the coupled separation elements connected with a connection element via a through-hole made in the relative thickness of the flexible base;
wherein the separation elements are composed of a polymeric material injected or micro-injected on the flexible base through the through-holes made in the relative thickness of the flexible base, and each of the coupled separation elements are connected to each other via the connection element, the connection element filling the through-hole, each of the coupled separation elements and the connection element being integrally connected, forming a single piece.

US Pat. No. 10,457,540

KIT OF PARTS FOR ASSEMBLING A HOSE CONNECTION, A FUEL DISPENSING UNIT HAVING SUCH A HOSE CONNECTION, AND A METHOD FOR ASSEMBLING SUCH A HOSE CONNECTION

1. A fuel dispensing unit, comprising:first and second fuel dispensing nozzles;
a first hose connection part comprising a single fuel outlet and a single fuel inlet, the single fuel outlet being in fluid communication with the first dispensing nozzle and the single fuel inlet being in fluid communication with the single fuel outlet, the single fuel inlet and the single fuel outlet facing a first direction; and
a second hose connection part comprising a single fuel outlet and a plurality of fuel inlets, the single fuel outlet being in fluid communication with the second dispensing nozzle and the plurality of fuel inlets being in communication with the single fuel outlet, the plurality of fuel inlets and the single fuel outlet facing the first direction;
wherein the single fuel outlet of the first hose connection part is not in fluid communication with the single fuel outlet of the second hose connection part,
wherein at least one of the first and second hose connection parts further comprises first and second vapor recovery ports.

US Pat. No. 10,457,538

WATER DISCHARGE DEVICE

Coway Co., Ltd, (KR)

1. A water discharge device comprising:a main body including a flow channel in which water flows and an outlet connected to the flow channel and the outside to allow water flowing in the flow channel to be discharged to the outside;
an opening and closing part including an opening and closing member movably provided in the flow channel to open and close an opening and closing hole formed in the flow channel; and
an operating part including a rotating rotary member and enabling the opening and closing member to move in the flow channel according to rotation of the rotary member in conjunction with the main body and the opening and closing part,
wherein the opening and closing part includes a movement switching member to which a connection part included in the opening and closing member is connected, the movement switching member moving in a length direction of the flow channel, while rotating according to rotation of the rotary member, and
wherein the movement switching member has a guide protrusion inserted into a guide hole formed in the main body to move and rotate, along the guide hole.

US Pat. No. 10,457,537

TOUCH SCREEN INTERFACE FOR A BEVERAGE DISPENSING MACHINE

Automatic Bar Controls, I...

1. A control system for a beverage dispenser, the control system comprising:a touch screen;
a plurality of beverage dispensing valves coupled to a plurality of fluid lines; and
a control unit electrically coupled to the touch screen and the plurality of valves, the control unit configured to:
display a graphical configuration on the touch screen for sanitizing the plurality of fluid lines;
receive an input from the touch screen selecting at least one fluid line for sanitization; and
control the plurality of valves to provide sanitizing fluid to the at least one selected fluid line for a predetermined time interval.

US Pat. No. 10,457,536

VEHICLE LIFT SYSTEM WITH ADAPTIVE WIRELESS COMMUNICATION

Gray Manufacturing Compan...

1. A wireless portable vehicle lift system comprising:a plurality of substantially identical individual lifts;
a detachable remote control physically connected in wired communication with one of said individual lifts; and
an adaptive communication system for providing wireless communication between said individual lifts, wherein said adaptive communication system is configured to automatically scan a plurality of communication channels and determine a clearest communication channel for wireless communication between said individual lifts,
wherein each of said individual lifts comprises—
a base for supporting said individual lift on a floor or the ground,
a post coupled to said base and extending upwardly from said base,
a carriage configured to engage a wheel of a vehicle,
a lifting actuator configured to vertically shift said carriage relative to said post,
a height sensor configured to measure a height of said carriage and/or vehicle,
a rechargeable battery,
a battery charger,
an e-stop button,
a transceiver configured to operate on said clearest communication channel, and
a user interface comprising a display screen,
wherein said user interface is configured to display height information, weight information, and battery status information,
wherein said user interface is configured to display a pass code screen that prompts the lift operator to enter a pass code,
wherein each of said individual lifts is configured to track and/or store lift data relevant to safety, maintenance, and/or proper operation of said lift system,
wherein each of said individual lifts is configured to provide a notification of maintenance needs based on said lift data,
wherein said lift system is configured to be selectively operated in a paired mode where two of said individual lifts are paired with one another and operate independently of the other of said individual lifts that are not paired.

US Pat. No. 10,457,535

ROTARY DUMPSTER

ROURA MATERIAL HANDLING, ...

1. A rotary dumpster for maneuvering a receptacle via a rotary fork lift assembly that includes a pair of forks, the rotary dumpster comprising:a base constructed and arranged to support the receptacle when in an upright position;
a first sidewall projecting upward from the base when in the upright position; and
first and second fork tubes located on the first sidewall and constructed and arranged to respectively receive the pair of forks for generally moving the rotary dumpster between the upright position and a dumping position, wherein the second fork tube is spaced above the first fork tube when in the upright position, and each of the first and second fork tubes extend longitudinally along the first sidewall.

US Pat. No. 10,457,534

HEAVY-DUTY LIFT TRUCK

1. A heavy-duty lift truck which is designed as a mast-based apparatus having a mast, wherein a load pick-up device is disposed so that it can be raised and lowered on the mast and the heavy-duty lift truck is arranged at least for a maximum load capacity of 8 t, wherein the heavy-duty lift truck comprises a power train with a travelling drive, wherein the travelling drive comprises an electric drive unit, and wherein the electric drive unit comprises an assembly with a direct voltage supply bus, an inverter connected thereto, a braking resistor connected to the inverter and an electric motor which can be actuated via the inverter and the electric motor is drivingly connected to a driving axle of the heavy-duty lift truck, and wherein the electric drive unit is connected via an electric line to a battery in order to be supplied with power, and wherein a direct current power controller is connected via a second electric line to the first electric line and a system battery and a vehicle computer are connected to the direct current power controller.

US Pat. No. 10,457,533

ARTICULATED BOOM TELEHANDLER

Oshkosh Corporation, Osh...

1. A telehandler comprising:a frame assembly;
a plurality of tractive elements rotatably coupled to the frame assembly;
an outrigger coupled to the frame assembly and selectively repositionable between a stored position and a deployed position, wherein in the deployed position the outrigger engages the ground to support a portion of a weight of the telehandler;
a cabin coupled to the frame assembly and configured to house an operator;
a boom assembly comprising:
a lower boom section having a proximal end pivotably coupled to the frame assembly and a distal end opposite the proximal end;
an intermediate boom section pivotably coupled to the distal end of the lower boom section; and
an upper boom section having a proximal end pivotably coupled to the intermediate boom section and a distal end configured to be coupled to an implement;
a locking mechanism selectively reconfigurable between a locked configuration and an unlocked configuration, wherein the boom assembly is configured to move freely when the locking mechanism is in the unlocked configuration, and wherein, in the locked configuration, the locking mechanism is configured to couple the intermediate boom section to the frame assembly such that the locking mechanism limits rotation of the lower boom section relative to the frame assembly; and
a controller operatively coupled to the locking mechanism, wherein the controller is configured to prevent the locking mechanism from changing from the locked configuration to the unlocked configuration in response to at least one of:
a weight of a payload supported by the implement exceeding a first threshold weight;
an orientation of the frame assembly being offset more than a threshold angle from a level orientation;
the outrigger not being in the deployed position; and
the portion of the weight of the telehandler supported by the outrigger being less than a second threshold weight.

US Pat. No. 10,457,532

PNEUMATIC WHEEL LIFT SYNCHRONIZATION

Gray Manufacturing Compan...

1. A self-synchronizing wheel lift system configured to lift a vehicle using compressed air, said lift system comprising:a plurality of pneumatic wheel lifts; and
a lift control system programmed to automatically synchronize the heights of said wheel lifts during vehicle lifting without causing any of said wheel lifts to completely stop during vehicle lifting,
wherein each wheel lift includes a pneumatic three-way valve for controlling actuation of said wheel lift,
wherein said lift control system comprises an electrical control system programmed to generate a pneumatic three-way valve control signal for each of said wheel lifts in said lift system,
wherein each valve control signal comprises a pulse-width modulated signal that includes a period T, wherein for each period T said pulse-width modulated signal includes one on portion and one off portion.

US Pat. No. 10,457,531

WINCH AND SAFETY DEVICE THEREOF

NINGBO CHINA WINCH CO., L...

1. A safety device of a winch, comprising:a power module;
a detection module;
a control module;
a display driving module; and
a display module;
wherein the display driving module is electrically connected to the display module; the display driving module and the detection module are electrically connected to the power module; the power module, the detection module and the display driving module are electrically connected to the control module;
wherein the control module is configured to convert a signal detected by the detection module into a control signal, and the control signal controls the display driving module to drive the display module to display;
wherein the power module includes a voltage boosting unit, a first voltage reducing and stabilizing unit, and a second voltage reducing and stabilizing unit,
wherein the first voltage reducing and stabilizing unit and the second voltage reducing and stabilizing unit are electrically connected to the voltage boosting unit, the first voltage reducing and stabilizing unit is electrically connected to the display driving module, the detection module and the control module are electrically connected to the second voltage reducing and stabilizing unit.

US Pat. No. 10,457,530

LIFT CRANE WITH MOVEABLE COUNTERWEIGHT

Manitowoc Cranes, LLC, M...

1. A mobile lift crane adapted to be configured in both a first configuration and a second configuration, the mobile lift crane comprising:a) a carbody;
b) moveable ground engaging members mounted on the carbody allowing the crane to move over the ground;
c) a rotating bed rotatably connected to the carbody about an axis of rotation; and
d) a boom pivotally mounted on the rotating bed and including a hoist line for handling a load;
e) a counterweight support frame connected to the rotating bed;
f) a moveable counterweight unit;
g) wherein in the first configuration,
i. a first mast is connected to the boom;
ii. a second mast pivotally is connected to the rotating bed, the second mast being connected to the first mast during at least a first pick, move, and set operation;
iii. a moveable counterweight support beam is coupled to the counterweight support frame and configured to move relative to the counterweight support frame while moving toward and away from the boom for use during the at least first pick, move, and set operation; and
h) wherein in the second configuration,
i. the first mast is absent from the mobile lift crane; and
ii. the mobile lift crane is configured such that it can perform at least a second pick, move, and set operation where the first mast is absent and the second mast is connected to the boom and the second mast can pivot in order to change the angle of the boom; and
i) wherein in the first and second configuration, the moveable counterweight unit is never supported by the ground other than indirectly by the moveable ground engaging members on the carbody during the at least first pick, move, and set operation and the at least second pick, move, and set operation;
m) wherein the mobile crane is adapted to be configured according to the first and the second configuration by at least:
the moveable counterweight unit adapted to (i) suspend below the rotating bed such that the moveable counterweight unit is operable to support counterweights positioned on opposing sides of the rotating bed and (ii) couple alternatively to the moveable counterweight support beam in the first configuration and to the counterweight support frame in the second configuration; and
the counterweight support frame adapted to couple alternatively to the moveable counterweight support beam and the moveable counterweight unit such that the moveable counterweight support beam is operable to move toward and away from the boom in the first configuration and the moveable counterweight unit is operable to move toward and away from the boom in the second configuration.

US Pat. No. 10,457,529

CRANE WITH ROTARY LOCKING MECHANISM

Manitowoc Crane Companies...

1. A telescoping boom, comprising:a base section having a base end and a telescoping end;
a first telescoping section disposed within the base section, the first telescoping section having a recess configured to receive a cylinder-to-section pin;
an inverted hydraulic actuator disposed within the base section, the inverted hydraulic actuator having a rod and a cylinder configured to extend and retract longitudinally relative to the base section;
a rotating element coupled to the cylinder, the rotating element having an axis of rotation parallel to a longitudinal axis of the base section and the cylinder-to-section pin perpendicular to the axis of rotation, the rotating element having a first configuration in which the cylinder-to-section pin engages the first telescoping section and a second configuration angularly offset from the first configuration in which the cylinder-to-section pin does not engage the first telescoping section; and
a motor coupled to the base section and the rotating element, the motor configured to rotate the rotating element and the cylinder-to-section pin relative to the base section.

US Pat. No. 10,457,528

DAVIT ARM

Engineered Supply, LLC, ...

1. A davit arm system comprising:an anchor fixedly attached to a building, the anchor comprising an anchor aperture;
a davit body attached to the anchor, said davit body having a length and comprising a mounting portion, a tension line and a mount, the mount moveable along the length of the davit body, the mount comprising a receptacle that defines a cavity, the tension line arranged to move the mount along the length of the davit body as the tension line is shortened, the mounting portion arranged to engage the anchor, the mounting portion comprising a body aperture, the body aperture aligned with the anchor aperture; and
an arm attached to the mount and supported by said davit body, a portion of the arm oriented in the cavity, a longitudinal axis of said arm oriented perpendicular to a longitudinal axis of said davit body, said arm moveable along the length of the davit body with the mount.

US Pat. No. 10,457,527

OPERATION DEVICE FOR MANUAL CONTROL OF A LOAD SUSPENDED IN THE OPERATION DEVICE

BINAR QUICK-LIFT SYSTEMS ...

1. An operation device for a manual control of a load suspended by the operation device comprising:a) a housing configured for suspending the load;
b) a first connection means, at least indirectly carried by the housing, for the connection of the operation device to a lifting device for the lifting and lowering of the operation device with the load;
c) a second connection device, at least indirectly carried by the housing, for the connection of the operation device to the load;
d) a handle, which is movably arranged in relation to the housing and the second connection device and which has a rest position between two end positions;
e) a sensor arranged inside the housing for the detection of a motion by the handle in relation to the housing and the second connection device, which sensor emits a signal corresponding to the movement of the handle from its rest position; and
f) a control unit for receiving the signal and as a result thereof control the lifting and lowering of the operation device with the load, wherein said sensor is an electromagnetic induction sensor comprising more than two coaxial coil components and a ferromagnetic core component, which is coaxially movable in relation to the coil components.

US Pat. No. 10,457,526

METHOD AND APPARATUS FOR DETECTING OVERLOAD DISTORTION

Tiger Lifting UK Limited,...

1. A method for detecting overload distortion in lifting gear comprising:(i) providing a hook which is susceptible to overload distortion;
(ii) providing said hook with three reference points at locations thereon defining, in an undistorted state of said hook, an isosceles or equilateral triangle; and
(iii) comparing the dimensions of two sides of said isosceles or equilateral triangle, one of which includes the dimension of said hook which is the more liable to dimensional increase in the case of overload distortion, after subjecting said hook to possible overloading.

US Pat. No. 10,457,525

HANDRAIL SYSTEM OF A PEOPLE MOVER AND METHOD FOR PREVENTING INJURIES IN A HANDRAIL SYSTEM OF A PEOPLE MOVER

Kone Corporation, Helsin...

1. A handrail system of a people mover, the handrail system comprising:a circulating handrail;
a safety system of a handrail inlet in a handrail housing, the safety system including,
a hatch associated with the handrail inlet in the handrail housing, the hatch including a first hatch part and a second hatch part, the first hatch part and the second hatch part configured to launch together simultaneously inwards into the handrail housing to form an opening around the handrail, and
a triggering device operationally connected between the hatch and the handrail housing to launch the hatch from a first position inwards into the handrail housing to a second position in response to an object touching either one of the first hatch part or the second hatch part or arriving to a safety area in front of the hatch; and
a coupling operatively connecting the circulating handrail and the safety system, the coupling configured to stop the handrail in response to one or more of (i) the launch of the hatch inwards into the handrail housing and (ii) a detection, by a sensor, of the object arriving to the safety area in front of the hatch.

US Pat. No. 10,457,524

TENSION DEVICE FOR DRIVE CHAIN, METHOD AND ESCALATOR SYSTEM USING SAME

KONE CORPORATION, Helsin...

1. An escalator system, comprisinga handrail band; and
a handrail band drive system, comprising a drive chain mounted and rotated around a driving wheel and a driven wheel, a tension device for the drive chain and a handrail band driving wheel coaxially connected to the driven wheel,
wherein the handrail band is pressed against the handrail band driving wheel and driven to circulate by a friction of the handrail band driving wheel, and
wherein the tension device comprises a pair of pressing blocks, each of which is provided on one of outer sides of portions of the drive chain between the driving wheel and the driven wheel respectively, and the pressing blocks apply pressures to the portions so as to move them close to each other, and
wherein the tension device further comprises a support assembly, secured on each of inner sides of the drive chain respectively on a bracket of the escalator so as to support the drive chain.

US Pat. No. 10,457,523

GUIDE RAIL SUPPORT CONFIGURED TO ACCOUNT FOR BUILDING SETTLING

OTIS ELEVATOR COMPANY, F...

1. A guide rail support for a guide rail of an elevator system, the guide rail support comprising:a guide rail bracket having a first side, a second side opposite the first side, a first mounting portion, and a second mounting portion, the first mounting portion configured to fixedly attach to a wall of an elevator shaft, the guide rail bracket having at least two inclined apertures defining elongated slots formed on a planar face of the second mounting portion;
an adjustment bracket configured to contact the second side of the guide rail bracket at the second mounting portion, the adjustment bracket having at least two inclined apertures defining elongated slots formed on a planar face of the adjustment bracket and are configured to align with the inclined apertures of the guide rail bracket to define respective stem apertures;
a first rotating member configured to be installed through one of the stem apertures; and
a second rotating member configured to be installed through the other of the stem apertures,
wherein each rotating member has (i) a first end defining a rotating head configured to movably engage with a base of the guide rail, (ii) an integrally formed stem configured to pass through the respective stem aperture and define a second end, and (iii) a middle integrally formed between the first end and the second end, the middle defining a length that is greater than a thickness of the guide rail bracket and the adjustment bracket.

US Pat. No. 10,457,522

LIMIT SWITCH SYSTEM INCLUDING FIRST LIMIT DEVICE AND SECOND LIMIT DEVICE

OTIS ELEVATOR COMPANY, F...

1. An elevator system comprising:a hoistway;
an elevator car to travel in the hoistway; and
a limit device configured to determine a position of the elevator car at a location of the hoistway upon operating the elevator car in an inspection state;
wherein the limit device includes a first limit device configured to determine a position of the elevator car at a first location of the hoistway in a normal state and a second limit device configured to determine the position of the elevator car at a second location of the hoistway upon operating the elevator car in an inspection state;
wherein the first location and the second location are located at a top of the hoistway, the first location positioned at a vertical location below the second location.

US Pat. No. 10,457,521

SYSTEM AND METHOD FOR ALTERNATIVELY INTERACTING WITH ELEVATORS

Inventio AG, Hergiswil (...

1. A method of operating an elevator installation, comprising:receiving an image signal at a computer from a video camera;
determining facial characteristics from a person's face data comprised in the image signal using the computer;
categorizing the facial characteristics into at least one of predefined emotion categories using the computer;
generating a control signal by the computer corresponding to the at least one of predefined emotion categories; and
operating the elevator installation an elevator controller in accordance with one of several operational modes, wherein the one of several operational modes is selected as a function of the control signal.

US Pat. No. 10,457,519

SAFETY CHUCK

Double E Company, LLC, W...

1. A safety chuck mounted to equipment that process web material, comprising:a spindle having an elongated, generally cylindrical body with a proximal end and a distal end, said proximal and distal ends defining a spindle longitudinal axis, said spindle distal end terminating in a jaw assembly, said spindle distal end having a spring aperture formed therein, said spring aperture positioned off-center from the spindle longitudinal axis, said moveable jaw having a corresponding spring aperture formed therein;
said jaw assembly having a static jaw fixedly attached to the spindle and extending forward of the spindle distal end, and a complimentary moveable jaw encased in a moveable, cylindrical shroud, said shroud having a rear surface facing an annular mounting flange front surface, and an opposite front surface, said shroud having a central aperture with the moveable jaw fixedly attached thereto, said shroud central aperture slideable over the spindle front distal end and static jaw, through the mounting flange front surface, a desired distance into an annular mounting flange interior, wherein the shroud is in a fully closed position when the shroud and moveable jaw are aligned with the static jaw;
an annular mounting flange holding said spindle, said annular mounting flange having a cylindrical housing leading to an annular mounting flange rear surface, said annular mounting flange rear surface facing the spindle proximal end, said annular mounting flange front surface formed into a flange in front of the housing, said annular mounting flange having a central, ring-like aperture formed therein, wherein the spindle body fits within the central ring-like aperture, wherein the spindle distal end terminates within the annular mounting flange central aperture past the mounting flange front surface;
a plurality of ball bearing rings positioned beneath a cylindrical housing within the central ring-like aperture against a spindle body surface;
a single die spring inserted into the spindle and moveable jaw spring apertures, said die spring forcing the shroud into a fully closed position;
a plurality of magnets attached about the mounting flange central aperture and facing toward the shroud rear surface, said shroud rear surface made from ferrous material, said shroud rear surface having a plurality of open slots formed therein, said slots spaced about the shroud rear surface, said magnets adapted to magnetically engage the shroud rear surface when the shroud rear surface engages the mounting flange interior, wherein as the shroud is rotated and the magnets become aligned with the open slots, magnetic engagement is broken.

US Pat. No. 10,457,518

WINDING MACHINE

1. A winding machine for a traversing application of a winding material to a spool sleeve comprisinga) a spindle,
said spindle being supported for being rotated and for having a fixed axial position and
said spindle having an inner recess,
b) a drive driving the spindle for a rotational movement,
c) a traversing carriage, said traversing carriage being supported on the spindle for being movable with a traversing motion in an axial direction relative to the spindle,
d) a first coupling element for transmitting the rotational movement of the spindle to the traversing carriage and
e) a second coupling element for transmitting the traversing motion of the traversing carriage to the spool sleeve,
f) an actuation mechanism,
said actuation mechanism executing the traversing motion,
said actuation mechanism comprising a coupling device which is coupled to the traversing carriage for transmitting the traversing motion from the actuation mechanism to the traversing carriage and
said actuation mechanism extending through the inner recess of the spindle.

US Pat. No. 10,457,516

SHEET STORAGE APPARATUS AND PRINTING APPARATUS

Canon Kabushiki Kaisha, ...

1. A printing apparatus comprising:a printing unit configured to perform printing on a sheet conveyed in a conveyance direction;
a discharge port configured to discharge the sheet on which printing has been performed by the printing unit;
a receiving unit configured to receive the sheet being discharged from the discharge port at a position below the discharge port; and
a sheet butting unit provided on an upstream side of the receiving unit with respect to the conveyance direction and configured to regulate movement of a front end of the sheet, wherein the sheet butting unit has a first surface provided facing the receiving unit and on which a plurality of projections are arranged, and a second surface provided above the first surface and on which a plurality of projections are arranged.

US Pat. No. 10,457,515

PAPER CONVEYANCE MECHANISM

STAR MICRONICS CO., LTD.,...

1. A paper conveyance mechanism capable of conveying paper in a conveying direction, drawn out from a roll paper formed by a long continuous paper wound in a roll shape with an inside surface of the paper on one side and another outside surface of the paper on the other side, comprising:an ironing part for correcting paper curl which is brought into contact with the outside surface of the paper while the paper is conveyed;
a pressing part which presses the inside surface of the paper to bend the paper at the ironing part; and
an arm engaged with an outer circumferential surface of the roll paper to be operated according to a change in a roll paper diameter of the roll paper,
wherein, when the roll paper diameter is above an upper limit setting value, the pressing part is kept stationary and keeping out of contact with the paper even when the arm is operated; and
wherein at least when the roll paper diameter is a certain value in a certain range below the upper limit setting value, the pressing part moves in a direction from the one side toward the other side in association with an operation of the arm while keeping in contact with the paper to reduce an interior angle formed in the paper in a bent state at the ironing part according to a decrease in the roll paper diameter.

US Pat. No. 10,457,514

SELF-CONTAINED TENSION CONTROL SYSTEM

The Montalvo Corporation,...

1. A self-contained tension control system comprising:a brake system configured to provide tension friction to a web;
a tension transducer idler roll to provide tension information indicative of tension of the web;
a controller configured to receive the tension information, to compare the tension information to set point information, and to provide a command signal to the brake system; and
an enclosure configured to enclose the brake system, the tension transducer idler roll, and the controller, the enclosure including a first web opening and a second web opening configured to allow the web to enter the enclosure and to pass through the enclosure to equipment downstream of the self-contained tension control system.

US Pat. No. 10,457,512

AUTOMATIC LAPLESS BUTT MATERIAL SPLICE

New Era Converting Machin...

1. A web splicer for on-the-fly splicing of an outgoing web with a replacement web arranged about a replacement roll and having a leading edge, the web splicer comprising:a cutting blade configured to cut the outgoing web to create a trailing edge;
a bump roller rotatable about a central axis and configured to rotate in communication with the outgoing web, the bump roller arranged proximate to the replacement roll and further configured to press the trailing edge of the outgoing web against a first adhesive surface coupled to the replacement web;
a splicer backup roller rotatable about a central axis and configured to rotate in communication with the outgoing web; and
a splicer roller rotatable about a central axis, arranged proximate to the splicer backup roller, and configured to receive a second adhesive surface, the splicer roller configured to selectively press the second adhesive surface against the leading edge of the replacement web and the trailing edge of the outgoing web;
wherein the web splicer produces a web splice having the first adhesive surface arranged on a first side of the splice and extending across both the leading edge of the replacement web and the trailing edge of the outgoing web, and the second adhesive surface arranged on a second side of the splice and extending across both the leading edge of the replacement web and the trailing edge of the outgoing web.

US Pat. No. 10,457,511

ROTATING MEMBER, SHEET TRANSPORT DEVICE, FIXING DEVICE, AND IMAGE FORMING APPARATUS

FUJI XEROX CO., LTD., To...

1. A rotating member comprising:a cylindrical or columnar rotating-member body that has one end portion and an outer circumferential surface and that is to be rotated;
identification information provided at the one end portion on the outer circumferential surface of the rotating-member body; and
a holding member that is provided at the one end portion of the rotating-member body, that holds the rotating-member body, and that has an inner circumferential surface in part of which a space not to be in contact with the outer circumferential surface of the rotating-member body is provided,
wherein the identification information is disposed in the space of the holding member.

US Pat. No. 10,457,510

RECORDING APPARATUS

Seiko Epson Corporation, ...

1. A recording apparatus comprising:a medium support unit that supports a medium to be fed;
a cylindrical feed roller that feeds the medium supported by the medium support unit;
a motive power transmitting unit that transmits a driving force from a driving source of the feed roller to the feed roller;
a separation roller that separates the medium by nipping the medium between the separation roller and the feed roller;
a return member that is switchable between a first orientation and a second orientation, the first orientation being an orientation in which a portion of the return member overlaps the feed roller in a side view of a medium feeding path, the second orientation being an orientation in which the return member is turned toward a downstream side in a medium feeding direction and does not overlap the feed roller in the side view, the return member changing an orientation thereof from the second orientation to the first orientation and thereby returning a leading end of the medium to an upstream side of a nip position between the feed roller and the separation roller;
a transport roller that is disposed on the downstream side of the feed roller in the medium feeding direction, the transport roller being rotatable in a normal direction and in a reverse direction; and
a control unit that controls the transport roller,
wherein the motive power transmitting unit is capable of entering a rotation allowing state by cutting torque transmission from the driving source to the feed roller, the rotation allowing state being a state in which free rotation of the feed roller is allowed,
wherein the return member is switchable to a third orientation, the third orientation being an orientation in which the return member is raised toward the upstream side further than in the first orientation, and
wherein the control unit drives the transport roller in reverse when the return member is in the third orientation during positioning control that is a control in which the transport roller is driven in reverse to return the medium to the upstream side and position the medium at a recording start position.

US Pat. No. 10,457,509

CARD TRANSPORT DEVICE

Brother Kogyo Kabushiki K...

1. A card transport device, comprising:a support surface configured to support one or more cards thereon;
a feed unit facing the support surface, and configured to feed the one or more cards supported on the support surface downstream in a transport direction along a transport path;
a separator located downstream from the feed unit in the transport direction, and configured to transport the cards fed by the feed unit downstream in the transport direction while separating the cards from one another;
a slope connected to a downstream support end of the support surface in the transport direction and extending obliquely upward downstream in the transport direction toward the separator; and
a restrictor located on the support surface, and configured to restrict a position of an upstream end in the transport direction of a particular card directly supported on the support surface, out of the one or more cards, thereby positioning a downstream end of the particular card to be downstream from the feed unit in the transport direction, wherein the restrictor is immovable relative to the support surface and has a receiving surface configured to receive the upstream end of the particular card.

US Pat. No. 10,457,508

SHEET MATERIALS SEPARATION-AIDING APPARATUS

OYABE SEIKI CO., LTD, To...

1. A sheet material separation-aiding apparatus used in combination with a sheet material separator for separating a specific sheet material from a stack of sheet materials, characterized by comprising;a rotating means including an abutment portion that is capable of coming in abutment on an end of said specific sheet material,
a supporting means that supports said rotating means in a rotatable manner and is capable of moving in a vertical direction,
a biasing means that biases said supporting means in a downward direction, and
a lifting means that lifts up an end of said rotating means in opposition to said abutment portion,
wherein said sheet material separation-aiding apparatus comprises, in order from said stack of sheet materials, said abutment portion, a center of rotation of said rotating means and the end of said rotating means in opposition to the abutment portion,
when the end of said rotating means in opposition to the abutment portion is lifted up, said rotating means rotates with said abutment portion coming in abutment on the end of said specific sheet material, and
when the end of said rotating means in opposition to the abutment portion is further lifted up, said supporting means and said rotating means keep on going up while said rotating means is kept from rotation by a counterforce that said abutment portion receives from said specific sheet material, whereby there is a gap between said specific sheet material in said stack of sheet materials and a sheet material below it.

US Pat. No. 10,457,507

SUPPLY UNIT AND IMAGE FORMING APPARATUS

Canon Kabushiki Kaisha, ...

1. A supply unit that is to be installed into an image forming apparatus, comprising:a supply member that supplies a sheet;
a unit body that includes an engaged portion to be engaged and supports the supply member; and
a cover member that includes a cover portion that covers the supply member and an engaging portion that is to engage with the engaged portion, the cover member being detachable from the supply unit both in a state in which the supply unit has been installed into the image forming apparatus and in a state in which the supply unit has not been installed into the image forming apparatus.

US Pat. No. 10,457,506

ENHANCED DEPLOYMENT OF SAFETY CAGE APPARATUS FOR TANKS ON VEHICLES

Sam Carbis Asset Manageme...

1. An apparatus for selectively controlling a source of pressurized fluid and thereby controlling the movement of a fall protection cage configured for surrounding a section of a work area at the top of rolling stock, the apparatus comprising:a fall protection cage configured to be extendable between a deployment orientation at a top of rolling stock and a storage orientation spaced apart from the top of rolling stock;
a gate pivotable between a closed position preventing worker access into the fall protection cage and an open position allowing worker access into the fall protection cage;
a gate lock configured and disposed for selectively assuming a locked orientation for selectively locking the gate in the closed position and alternatively assuming an unlocked orientation for selectively freeing the gate to assume the open position;
a two-position lever operated directional valve having an inlet coupling connected via a first pressure line to the source of pressurized fluid, the two-position lever operated directional valve having an outlet coupling; and
a gate lock cylinder having an inlet connected via a second pressure line to the outlet coupling of the two-position lever operated directional valve, the gate lock cylinder being connected to the gate lock; and
wherein the two-position lever operated directional valve is configured for selectively connecting the first pressure line to the second pressure line whereby the gate lock cylinder becomes biased to maintain the gate lock in the locked orientation.

US Pat. No. 10,457,505

IMPROVEMENTS RELATING TO THE STACKING AND RECLAIMING OF BULK MATERIALS

Kilic Inventions Pty Ltd,...

1. A mobile stacker and reclaimer combination, comprising a mobile stacker, and a mobile reclaimer comprising a base riding on a conveyance means, a tower which extends up from the base, at least one elongate collector for a bulk material suspended from the base at or near ground level so as to be extending transversely, the at least one collector comprising an outlet and at least one powered conveyor driving bulk material collected in the at least one collector toward the outlet, an elevator conveying the bulk material from the at least one collector up the tower to a slewing conveyor boom mounted atop the tower, and a power train so that the mobile reclaimer is movable independently to the mobile stacker, wherein, in use, the mobile reclaimer simultaneously collects the bulk material and feeds the bulk material to the mobile stacker.

US Pat. No. 10,457,504

TRANSPORTABLE RECEIVING AND STORAGE SYSTEM

Quickthree Technology, LL...

30. A system comprising:an elevating conveyor assembly comprising an elevating conveyor configured to discharge granular material, at an upper end of the elevating conveyor assembly, selectively to a top input opening of a surge bin or to an input of a distribution conveyor assembly,
wherein the distribution conveyor assembly comprises a distribution conveyor that extends outwardly from the upper end of the elevating conveyor assembly.

US Pat. No. 10,457,503

APPARATUS AND METHOD FOR INTERMODAL DISTRIBUTION OF FREIGHT

1. A method of redistributing freight between freight containers, the method comprising:receiving a loading/unloading opening of a first freight container at a first of at least three openings in a moveable cross-dock having a plurality of surface road wheels, a body defining an interior storage area, and at least three openings in the body through which freight may be moved into and out of the interior storage area;
receiving a loading/unloading opening of a second freight container at a second of the at least three openings in the body of the moveable cross-dock;
receiving a loading/unloading opening of a third freight container at a third of the at least three openings in the moveable cross-dock while the loading/unloading openings of the first and second freight containers are proximate the first and second openings in the body of the moveable cross-dock; and
redistributing freight between the first freight container, the second freight container, and the third freight container via the at least three openings in the body of the moveable cross-dock.

US Pat. No. 10,457,502

TOOL AND METHOD FOR LAYER DEPALLETIZING

SYMBOTIC CANADA ULC, Laf...

1. A tool for layer depalletizing comprising:a frame for mounting the tool to a robot;
clamps movably mounted to the frame to grip a pallet layer;
curtains mounted to the frame below the clamps and being disposed so as to move relative to the clamps under the pallet layer while the pallet layer is gripped by the clamps, where a pressure on the clamps against the pallet layer is automatically adjusted by a controller depending on a movement resistance of the curtains against products in the pallet layer with the curtains movement relative to the clamps for insertion under the pallet layer.

US Pat. No. 10,457,501

SYSTEMS AND METHODS FOR CONVERTER BED UNLOADING AND LOADING

Cyclone Catalyst Properti...

1. A system for unloading material from a converter bed, the system comprising:(a) a vacuum source;
(b) a dust collector connected to the vacuum source by a first vacuum hose;
(c) a cyclone, the cyclone comprising:
(i) an outer chamber wall forming a housing;
(ii) an inner chamber wall, the inner chamber wall defining an inner chamber, wherein the inner chamber further comprises a drop-out region;
(iii) an inline feed inlet forming a passage into the inner chamber, wherein a terminal end of the inline feed inlet pipe does not extend substantially past the inner chamber wall, wherein a portion of the inline feed inlet pipe that forms the passage extending from outside an exterior of the outer chamber wall to the inner chamber is not angled and comprises a substantially uniform diameter, and wherein the inline feed inlet pipe forms the passage to the inner chamber through a vertical side portion of the cyclone and is substantially perpendicular relative thereto;
(iv) an outlet forming a passage out of a top portion of the cyclone;
(v) a material drop-out outlet forming a passage out of the drop-out region of the inner chamber, wherein the material drop-out outlet is disposed at a bottom portion of the cyclone; and
wherein the cyclone is operatively connected to the vacuum source through the dust collector, and wherein the cyclone is connected to the dust collector by a second vacuum hose; and
(d) a feed hose connected to the cyclone.

US Pat. No. 10,457,500

AGRICULTURAL VEHICLE PNEUMATIC DISTRIBUTION SYSTEM

1. An agricultural implement comprising:a product source;
a metering system configured to meter agricultural from the product source; and
an agricultural pneumatic distribution system configured to pneumatically distribute the metered agricultural product to a plurality of end point components on the agricultural implement, the pneumatic distribution system comprising:
a fan assembly having an outlet; and
a plurality of conduits, each configured to receive an air stream for conveying the agricultural product to at least one of the end point components, wherein
a first one of conduits corresponds to a first distribution line and is positioned such that the first conduit receives a first air stream from a high pressure area of the outlet, and
a second one of the conduits corresponds to a second distribution line and is positioned such that the second conduit receives a second air stream from a low pressure area along the outlet,
the first distribution line having a higher pressure drop than the second distribution line.

US Pat. No. 10,457,499

HANDLING DEVICE WITH SUCTION CUP FOR FOODSTUFF

Piab Aktiebolag, Taby (S...

1. A suction cup for handling foodstuff, comprising:a suction opening for applying a suction force to a surface of the foodstuff to be handled,
a drive opening for receiving a separate drive nozzle, and
an outlet nozzle integrally formed with the suction cup as a unitary piece and having at least one constriction, wherein the outlet nozzle is aligned with the drive opening, and wherein the suction cup is configured for being removably attached to a docking piece for supporting the suction cup,
the suction cup being configured such that the drive nozzle, when received in the drive opening, and the outlet nozzle cooperate to form an ejector for providing a suction force to the suction opening.

US Pat. No. 10,457,498

TRANSFER DEVICE AND TRANSFER METHOD

BOE TECHNOLOGY GROUP CO.,...

1. A transfer device, comprising a first conveyance roller, a transfer roller and a second conveyance roller, whereinthe transfer roller includes a roller body and a plurality of first stamp contacts formed on and protruded from a peripheral surface of the roller body,
the first stamp contacts are able to absorb elements to be transferred,
an axis of the first conveyance roller, an axis of the transfer roller and an axis of the second conveyance roller are arranged in parallel with each other,
the transfer roller is interposed between the first conveyance roller and the second conveyance roller,
a first roll gap is formed between the first conveyance roller and the transfer roller to convey a medium substrate, and a second roll gap is formed between the second conveyance roller and the transfer roller to convey a target substrate, and
the transfer device further includes a driving mechanism configured to rotate the first conveyance roller, the transfer roller and the second conveyance roller.

US Pat. No. 10,457,497

ELECTROMAGNETIC CONVEYOR SYSTEM

Laitram, L.L.C., Harahan...

1. A conveyor system comprising:a first conveyor conveying electrically conductive articles in a first direction to an exit end;
a second conveyor conveying the electrically conductive articles from an entrance end in a second direction different from the first direction;
a diverter forming a junction between the exit end of the first conveyor and the entrance end of the second conveyor;
wherein the diverter includes:
a top surface;
an entrance adjacent to the exit end of the first conveyor receiving the electrically conductive articles on the top surface from the exit end of the first conveyor;
an exit adjacent to the entrance end of the second conveyor;
a plurality of coils arranged in a matrix of contiguous first and second zones below the top surface, wherein the coils in each of the first zones produce an electromagnetic flux wave that travels in the first direction and forces the electrically conductive articles on the top surface above the zone to move in the first direction and the coils in each of the second zones produce an electromagnetic flux wave that travels in the second direction and forces the electrically conductive articles on the top surface above the zone to move in the second direction, wherein at least some of the zones along the entrance are first zones and at least some of the zones along the exit are second zones;
wherein some of the coils in the diverter are in the first zones and the rest of the coils are in the second zones;
wherein the electrically conductive articles are directed from the entrance to the exit by the coils in the first and second zones and onto the second conveyor.

US Pat. No. 10,457,496

UNLOADING DEVICE

ROTZINGER AG, Kaiseraugs...

1. An unloading device for unloading products located on product carrier trays, which in turn are disposed in product carrier shuttles of a chain store, onto outfeed conveyor belts, comprising:a main conveyor belt having a transfer edge and an outlet side, the transfer edge being adjacent to the product carrier shuttles and the outlet side being opposite to the transfer edge, and the main conveyor belt is hinged at the outlet side to enable vertical pivoting of the transfer edge; and
at least one additional belt located above the main conveyor belt and being mechanically connected in a stationary manner to the main conveyor belt for common vertical pivoting together with the main conveyor belt,
wherein the at least one additional belt is shorter than the main conveyor belt.

US Pat. No. 10,457,495

OPERATION OF AN ACTIVE CONTROL ROLLER TOP CONVEYING ASSEMBLY

Rexnord Industries, LLC, ...

1. A method of turning an object on a conveyor assembly, the method comprising:supporting the object on first rollers of the conveyor assembly defining a first motion zone, wherein a first clutch is operably connected to the first rollers by a first roller axle, the first clutch including a first driven member fixed to the first roller axle and a first driving member adjacent to the first driven member, and second rollers of the conveyor assembly defining a second motion zone, wherein a second clutch is operably connected to the second rollers by a second roller axle, the second clutch including a second driven member fixed to the second roller axle and a second driving member adjacent to the second driven member, and wherein the first rollers and the second rollers move along a length of the conveyor assembly;
activating the first clutch such that the first driven member engages with the first driving member to drive the first roller axle to rotate the first rollers in a first direction when moving along the length of the conveyor;
activating the second clutch such that the second driven member engages with the second driving member to drive the second roller axle to rotate the second rollers in a second direction, opposite the first direction, when moving along the length of the conveyor; and
turning the object as a result of the relative rotation of the first rollers and the second rollers.

US Pat. No. 10,457,494

HEATED BELT SCRAPER BAR APPARATUS

1. A heated scraper bar assembly for a conveyor belt system, the scraper bar assembly comprising:a reservoir, the reservoir configured to retain a liquid;
a heating-element, the heating-element configured to heat the liquid in the reservoir; and
a scraping-system, the scraping system affixed to the reservoir and in thermal communication with the liquid; and
wherein the scraper bar assembly is configured to remove frozen debris from an active conveyor belt system.

US Pat. No. 10,457,493

INDEXING CONVEYOR SYSTEM AND METHOD

SST Systems, Inc., Sturg...

1. A conveyor system comprising:a rail defining a path of conveyance;
a plurality of sequential work stations positioned along the path of conveyance;
a plurality of carriages slidable along the rail, the plurality of carriages including
a first carriage supporting a load through the plurality of sequential work stations, and
a second carriage in a leading or downstream position with respect to the first carriage, the second carriage being unloaded;
an indexing system adapted to drive the plurality of carriages in discrete steps, each step advancing the plurality of carriages by an index length equal to a length of each of the plurality of sequential work stations; and
a work station skipping device operable to engage the load and transfer the load from the first carriage to the second carriage for skipping over a predetermined one of the plurality of sequential work stations.

US Pat. No. 10,457,492

TUBULAR MEZZANINE AND CONVEYOR SUPPORT STRUCTURES AND STIFFENER BRACKETS FOR ASSEMBLY THEREOF

ROACH MANUFACTURING CORPO...

1. A support structure for conveyors and mezzanines comprising:a plurality of elongated interlocking tubular members, each tubular member having four sides and a substantially rectangular lateral cross section, said four sides including an inner side and an outer side joined by two adjoining sides, the inner side and two adjoining sides of a first tubular member defining a cutout configured to interlock with a complementary cutout defined by the inner and adjoining sides of a second tubular member to which the first tubular member is interlocked in a perpendicular relationship;
a pair of stiffener brackets, each bracket having a planar body with apertures therein, a first bracket positioned on the outer side of the first tubular member and a second bracket positioned on the outer side of the second tubular member when the tubular members are interlocked with said apertures in alignment;
fastening members inserted through said apertures and secured so as to clamp the two brackets and the first and second tubular members together; and
at least one support surface formed by said plurality of tubular members when said tubular members are interlocked and clamped with said stiffener brackets and fastening members; and
a supported structure selected from the group consisting of 1) a conveyor, 2) a mezzanine, and 3) both a conveyor and a mezzanine in combination, said supported structure being supported on said support surface in an operable configuration.

US Pat. No. 10,457,491

CONVEYING SYSTEMS AND METHODS OF USE

1. A conveying system assembly, comprising:a. a conveyor for moving items along a conveying path;
b. at least one lateral sidewall positioned longitudinally along said conveyor, and
c. a sweeping device operable to clear said items from said conveyor by moving along a length of said conveyor, said sweeping device being positioned on a first side of said at least one lateral sidewall and magnetically coupled to a driving mechanism positioned on a second side of said at least one lateral sidewall.

US Pat. No. 10,457,490

TRANSFER APPARATUS AND HOLDING APPARATUS

Kabushiki Kaisha Toshiba,...

1. A transfer apparatus, comprising:a base;
a first linear motion member supported by the base and movable in a first direction;
a second linear motion member supported by the first linear motion member and movable in a second direction crossing the first direction;
a moving conveyor supported by the second linear motion member and including a belt for conveying an article;
an extraction arm that extracts the article and places the article on the belt; and
a holding part, provided at an end of the extraction arm, that holds the article, the holding part including an elastic passive joint provided at the end of the extraction arm, and a first end member and a second end member connected to the elastic passive joint, the first end member and the second end member being held by the elastic passive joint to be approximately orthogonal to each other in a state where the first end member and the second end member are out of contact from the article, and to be approximately orthogonal or approximately parallel to each other in a state where the first end member and the second end member are in contact with the article.

US Pat. No. 10,457,489

PALLET TRANSPORT DEVICE

NITTOKU ENGINEERING CO., ...

1. A pallet transport device comprising:a plurality of pallet rails configured to movably guide a pallet;
a plurality of moving mechanisms provided for the respective pallet rails, the plurality of moving mechanisms being configured to move the pallet along the pallet rails;
a transfer mechanism including a pivoting member and a retaining rail, the pivoting member being pivotable around a pivot axis in a horizontal direction, the retaining rail being mounted on the pivoting member and capable of retaining the pallet, the transfer mechanism being configured to transfer the pallet guided by one of the pallet rails to another one of the pallet rails using the pivoting member and the retaining rail;
a moving assistance mechanism configured to move the pallet from the pallet rails to the retaining rail, or from the retaining rail to the pallet rails; and
an elevator mechanism configured to cause the moving assistance mechanism to ascend and descend, wherein
when the elevator mechanism has caused the moving assistance mechanism to descend, the transfer mechanism becomes in a state where the transfer mechanism is capable of causing the pivoting member to pivot.

US Pat. No. 10,457,488

VERTICAL SPIRAL CONVEYOR

Mayfran International, In...

1. A vertical spiral conveyor for transporting loose material without the use of vibration or oscillation, comprising:a frame;
a vertical spiral fabrication comprising a spiral conveyor tray connected to a vertical member that is configured to rotate about an axis of rotation;
a drive arm extending from the vertical spiral fabrication;
a drive system for rotating the vertical spiral fabrication about the axis of rotation, the drive system comprising a power source and a transmission coupled to the drive arm;
at least one means for assisting and/or resisting the rotation of the vertical spiral fabrication attached between the frame and at least one of the vertical spiral fabrication and the drive arm; and
wherein the drive system generates alternating forward and backward strokes on the drive arm that rotate the vertical spiral fabrication clockwise and counterclockwise about the axis of rotation to cause loose material to be conveyed around the spiral conveyor tray.

US Pat. No. 10,457,487

SORTING CONVEYOR AND BELT

Laitram, L.L.C., Harahan...

1. A conveyor belt comprising:an endless belt body having a top and an opposite bottom extending laterally from a first side to a second side and longitudinally in a direction of belt travel;
wherein the belt body includes a plurality of openings extending through the belt body from the top to the bottom and indented laterally inward of the first and second sides and spaced apart longitudinally;
a plurality of doors associated with the plurality of openings and movably attached to the belt body for movement from first positions occluding the openings to support articles in the openings to second positions away from the openings to release articles through the openings.

US Pat. No. 10,457,486

DOUBLE PORTABLE DRIVE-OVER HOPPER

Sudenga Industries, Inc.,...

1. An apparatus comprising:a transverse conveyor configured to move material in a first direction;
a first pair of foldable parallel ramps extending from a first side of the transverse conveyor, the ramps of the first pair being spaced apart for reception of vehicle wheels thereon;
a first foldable longitudinal conveyor extending from the first side and positioned between the ramps of the first pair and configured to move material toward the transverse conveyor in a second direction that is substantially orthogonal to the first direction, wherein the transverse conveyor comprises an inlet, and wherein the first foldable longitudinal conveyor extends from the first side of the transverse conveyor proximate the inlet;
a second pair of foldable parallel ramps extending from a second side of the transverse conveyor, the ramps of the second pair being in alignment with the ramps of the first pair;
a second foldable longitudinal conveyor extending from the second side and positioned between the ramps of the second pair and configured to move material toward the transverse conveyor in a third direction that is substantially opposite the second direction; and
a plate disposed over the inlet, wherein:
the plate has a top surface and a bottom surface;
the plate has a first position configured so that at least some material moving in the second direction impinges the bottom surface; and
the plate has a second position in which the plate extends upwardly and outwardly from the inlet.

US Pat. No. 10,457,485

PHARMACEUTICAL DISPENSING SYSTEM AND ASSOCIATED METHOD

REMEDI TECHNOLOGY HOLDING...

1. An automation apparatus for dispensing groups of individually packaged products, the apparatus comprising:a storage arrangement adapted to store a plurality of products each contained in an individual package, wherein the storage arrangement comprises a first module and a second module, wherein the first module is adapted to store products having a first frequency demand threshold and the second module is adapted to store products having a second frequency demand threshold that is lower than the first frequency demand threshold;
a plurality of fixed first discharge assemblies adapted to move selected ones of the individual packages from the first module of the storage arrangement;
a second discharge assembly comprising a moveable pick device, the second discharge assembly adapted to move selected ones of the individual packages out of the second module of the storage arrangement;
a transfer station adapted to receive and hold the individual packages selected from the second discharge assembly; and
a conveyor having assigned spaces, each assigned space adapted to receive the selected individual packages first from the first discharge assemblies and then from the transfer station.