US Pat. No. 10,167,351

METHODS OF CONTROLLING POLYOLEFIN MELT INDEX WHILE INCREASING CATALYST PRODUCTIVITY

Univation Technologies, L...

1. A method comprising:contacting in a fluidized bed gas phase reactor an olefin monomer with a catalyst system in the presence of an induced condensing agent (ICA) to produce a first polyolefin having a first melt index, the catalyst system comprising a metallocene catalyst;
increasing a partial pressure of the ICA in the reactor to produce a second polyolefin having a second melt index;
wherein increasing the partial pressure of the ICA results in a higher catalyst productivity for producing the second polyolefin when compared to the catalyst productivity for producing the first polyolefin.

US Pat. No. 10,167,333

NEUTRALIZING HUMAN MONOCLONAL ANTIBODIES AGAINST HEPATITIS B VIRUS SURFACE ANTIGEN

1. An antibody or fragment thereof capable of specifically binding to the Hepatitis B surface antigen (HBsAg) and having Hepatitis B Virus (HBV) neutralizing activity, wherein said antibody or fragment thereof comprises a light chain CDR1 region comprising the amino acid sequence of SEQ ID NO: 5, a light chain CDR2 region comprising the amino acid sequence of SEQ ID NO: 6, a light chain CDR3 region comprising the amino acid sequence of SEQ ID NO: 7, a heavy chain CDR1 region comprising the amino acid sequence of SEQ ID NO: 8, a heavy chain CDR2 region comprising the amino acid sequence of SEQ ID NO: 9 and a heavy chain CDR3 region comprising the amino acid sequence of SEQ ID NO: 10.

US Pat. No. 10,167,319

CAGED CELL PENETRATING PEPTIDE-POLYMER CONJUGATES FOR DIAGNOSTIC AND THERAPEUTIC APPLICATIONS

1. A caged cell penetrating peptide (cCPP)-macromolecular carrier conjugate of formula 1:
wherein
x, y, u, and z are independently percentages of the respective element composition of the conjugate, wherein x is present from 0.05%-50%, y is present from 0-50%, u is present from 0-50% and z is present from 0-50%;
P is a caged cell penetrating peptide, wherein the amino acid sequence of the cell penetrating peptide comprises the amino acid sequence KRRMKWKK;
M is a macromolecular carrier molecule consisting of underivatized monomers selected from the group consisting of N (2-hydroxypropyl)methacrylamide (HPMA), N-methylacrylamide, N,N-dialkylacrylamides, acrylic acid, polyethylene glycol, methacrylic acid, polyamino acids, polysaccharides, polyvinyl pyrrolidone-maleic anhydride polymers, polylactic-co-glycolic acid, and combinations thereof;
D is a detectable agent or a therapeutic agent, or a combination thereof, wherein said detectable agent is fluorescent, radioactive, luminescent or electron dense, and wherein said therapeutic agent is a toxin, a chemotherapeutic agent, D(KLAKLAK)2, KLAK, a radioisotope, an antimetabolite, a microtubule inhibitor, or a combination thereof; and
J and K are spacer molecules.

US Pat. No. 10,167,314

METHODS OF TREATING DEPRESSION AND OTHER RELATED DISEASES

Northwestern University, ...

1. A method for treating a patient suffering from postpartum depression comprising administering to said patient an effective amount of a GLYX-13 peptide represented by formula:or a pharmaceutically acceptable salt thereof.

US Pat. No. 10,167,313

SELECTIVE CASPASE INHIBITORS AND USES THEREOF

Genesis Technologies Limi...

1. A method for inhibiting a caspase in a subject in need thereof, comprising administering to said subject an effective amount of a compound of Formula 1:whereina is 0 or 1;
b is 0 or 1 provided that when b is 0, a is 0;
A is
1) H,
2) C1-C6 alkyl,
3) aryl,
4) heteroaryl,
5) heterocyclyl,
6) R3—C(O)—,
7) R3—OC(O)—,
8) R3—C(O)O—,
9) R3—S(O)2—, or
10) PhCH2OC(O)—;
P2, P3, P5, when present, and PX, when present, are any (D) or (L) amino acid residue or a non-natural amino acid residue;
P4 is any (D) or (L) amino acid selected from the group consisting of Ala, Arg, Asp, Asn, Cys, Glu, Gln, Gly, Ile, His, Leu, Lys, Met, Phe, Pro, Ser, Thr, Trp, and Val, or non-natural amino acid residue;
the line “-” when located between P2, P3, P4, P5 or PX represents a peptide bond or a peptidomimetic bond;
the wavy line represents either cis or trans orientation of R1and R2;
R1 is
1) aryl,
2) heteroaryl,
3) heterocyclyl,
4) C2-C6alkene-R20,
5) S2R5,
6) SO3R5,
7) SOR5,
8) SONHR5,
9) SO2NHR5,
10) CN,
11) CO2R5,
12) COR5,
13) PO3R5,
14) PO(OR5)2, or
15) PO(OR5),
wherein the aryl, the heteroaryl, or the heterocyclyl are optionally substituted with one or more R30;
R2 is
1)R1,
2) H,
3) halogen,
4) haloalkyl,
5) C1-C6 alkyl,
6) C2-C6 alkene,
7) C3-C7 cycloalkyl,
8) OR9;
9) OCOR6,
10) OCO2R6,
11) NR7R8,
12) NHSO2R6,
13) NHCOR6,
14) aryl,
15) heteroaryl, or
16) heterocyclyl;
R3 is
1) C1-C6 alkyl,
2) aryl,
3) heteroaryl, or
4) heterocyclyl;
R4 is
1) H, or
2) C1-C6 alkyl;
R5 is
1) H,
2) C1-C6 alkyl,
3) C2-C6 alkene,
4) C3-C7 cycloalkyl,
5) aryl,
6) heteroaryl,
7) heterocyclyl, or
8) any optionally protected (D) or (L) amino acid residue;
R6 is
1) any (D) or (L) amino acid residue,
2) C1-C6 alkyl,
3) C3-C7 cycloalkyl,
4) aryl,
5) heteroaryl, or
6) heterocyclyl,
in which the alkyl or the cycloalkyl are optionally substituted with one or more R10 substituents; and in which the aryl, heteroaryl or heterocyclyl are optionally substituted with one or more R20 substituents;
R7 and R8 are independently selected from:
1) H,
2) C1-C6 alkyl,
3) C3-C7 cycloalkyl,
4) haloalkyl,
5) aryl,
6) heteroaryl, or
7) heterocyclyl,
wherein the alkyl and the cycloalkyl are optionally substituted with one or more R10 substituents, and the aryl, the heteroaryl and the heterocyclyl are optionally substituted with one or more R20 substituents;
R9 is
1) H,
2) C1-C6 alkyl,
3) C3-C7 cycloalkyl,
4) aryl,
5) heteroaryl, or
6) heterocyclyl,
in which the alkyl or the cycloalkyl are optionally substituted with one or more R10 substituents; and in which the aryl, heteroaryl or heterocyclyl are optionally substituted with one or more R20 substituents;
R10 is independently selected from:
1) halogen,
2) C1-C6 alkyl,
3) C3-C7 cycloalkyl,
4) haloalkyl,
5) aryl,
6) heteroaryl,
7) heterocyclyl,
8) OR9,
9) S(O)mR9,
10) NR7R8 ,
11) COR9,
12) C(O)OR9,
13) OC(O)R9,
14) SC(O)R9,
15) CONR7R8, or
16) S(O)2NR7R8;
R20 is independently selected from:
1) halogen,
2) NO2,
3) CN,
4) C1-C6 alkyl,
5) haloalkyl,
6) C3-C7 cycloalkyl,
7) OR7,
8) NR7R8,
9) SR7,
10) aryl,
11) heteroaryl,
12) heterocyclyl,
13) SO2R5,
14) SO3R5,
15) SOR5,
16) SONHR5,
17) SO2NHR5,
18) PO3R5,
19) PO(OR5)2,
20) PO(OR5),
21) COR7,
22) CO2R7,
23) S(O)mR7,
24) CONR7R8, or
25) S(O)2NR7R8,
wherein the alkyl and the cycloalkyl are optionally substituted with one or more R6 substituents; and wherein the aryl, the heteroaryl, or the heterocyclyl are optionally substituted with one or more R30;
R30 is
1) NO2,
2) C2-C6 alkene-R20,
3) SO2R5,
4) SOR5,
5) SONHR5,
6) SO2NHR5,
7) CN,
8) CO2R5,
9) CORS,
10) PO3R5,
11) PO(OR5)2, or
12) PO(OR5); and
wherein m is an integer of 0, 1, or 2;
or a pharmaceutically acceptable salt thereof.

US Pat. No. 10,167,310

SYSTEM AND METHOD FOR PRODUCING INTERLEUKIN RECEPTOR ANTAGONIST (IRA)

ESTAR TECHNOLOGIES LTD, ...

1. A system for preparing autologous IL-1RA cytokine comprising:a. a blood collection tube;
b. a tube cover adapted to be received over an open end of the blood collection tube for maintaining said tube closed;
c. a portion of separation gel in the blood collection tube;
d. an anticoagulant portion in the blood collection tube;
e. a plasma collection syringe comprising a sharp needle configured to be inserted into the blood collection tube;
f. a buffy coat collection syringe configured to be inserted into the blood collection tube; and
g. an incubation tube separate from said blood collection tube with a cover, said incubation tube comprising washed and pretreated borosilicate glass beads in a size range of about 0.5-5 mm and adapted to receive contents of the buffy coat collection syringe removed from the blood collection tube;
wherein said blood collection tube is a vacuum tube; said separation gel and said anticoagulant are in said vacuum tube; said separation gel is adapted as a barrier and as a separating element between separation tractions;
further wherein said blood collection tube is adapted such that, when containing whole blood, after centrifugation yields separation fractions comprising, a first fraction of red blood cells sediment, a second fraction of said separation gel, a third fraction comprising white blood cells and platelets, and a fourth fraction of plasma solution.

US Pat. No. 10,167,308

HIGHLY EFFICIENT SYNTHESIS OF LONG RNA USING REVERSE DIRECTION APPROACH

ChemGenes Corporation, W...

1. A process of synthesizing an RNA oligonucleotide of the following formula:
wherein:
B is a member selected from the group consisting of adenine, cytosine, guanine, uracil, 6-oxopurine, 5-methyl-cytosine, 5-methyl-uracil, 5-fluro-uracil, 7-deaza-adenine, 7-deaze-adenine and 5-fluro-cytosine;
n is an integer from 100 to about 200;
L is a nucleoside, or a non-nucleoside ligand wherein the non-nucleoside ligand is a member selected from the group consisting of cholesterol with a linker or a spacer, biotin, ethyleneglycol, glycerol, a polyethyelenglycol, a hexaehtyleneglycol, an amino linker, a disulfide linker, a peptide linker, a polypeptide linker, a protein, a flurophore, a quencher dye, one or more 2?,5?-linked deoxynucleoside unit, one or more 2?,5?-linked ribonucleoside unit, and one or more 2?,5?-linked deoxyribose unit,
wherein L is attached at the 3?-end of the RNA nucleotide through an intervening phosphate; and
the process of synthesizing the RNA oligonucleotide is in a direction from the 5?-end to the 3?-end of the RNA nucleotide, and the process comprises the steps of:
(a) taking a nucleoside solid support represented by Formula 2:

wherein:
M is a linker represented by the formula Y—C(O) and optionally connected to a solid support suitable for oligonucleotide synthesis,
wherein Y is a hydrocarbon diradical moiety having a length between 2 carbons and 20 carbons, and Y is selected from the group consisting of alkyl, alkenyl, cycloalkyl, aryl, and aralkyl, and the hydrocarbon diradical moiety optionally comprises intervening —O—, —S—, —S(O)2— —C(O)— and —NR6— where R6 is a hydrogen radical, or a substituted C1 to C20 alkyl or a substituted aralkyl;
W is selected from the group consisting of an oxygen diradical, an N—H diradical, and a fluorine radical, and R is selected so that:
if W is an oxygen diradical, then R is tert butyl dimethyl silyl (TBDMS) or triisopropylsilyl oxymethylene (TOM); and
if W is an N—H diradical, then R is of the form R5x, where x is selected from the group consisting of fluorenylmethyloxycarbonyl (Fmoc), trifluoroacetyl, acetyl, alkanoyl and aroyl; and
if W is a fluorine radical, then R is not present;
B is selected from the group consisting of nucleoside base radicals consisting of 9-(N6-benzoyladeninyl)-, 9-(N6-acetyladeninyl)-, 9-(N6-tert-butyl phenoxyacetyladeninyl)-, 9-(N6-phenoxyacetyladeninyl)-, 9-(N6-isopropyl phenoxyacetyladeninyl)-, 1-(N6—(N,N-dimethylformamidinyl)adeninyl), 1-(N4-benzoylcytosinyl)-, 1-(N4-acetylcytosinyl)-, 1-(N4—(N,N-dimethylformamidinyl)cytosinyl)-, 1-(N4-phenoxyacetylcytosinyl)-, 1-(N4-tert-butylphenoxyacetylcytosinyl)-, 1-(N4-isopropyl phenoxyacetylcytosinyl)-, 9-(N2-isobutylguaninyl)-, 9-(N2-tert butyl phenoxyacetylguaninyl)-, 9-(N2-isopropyl phenoxyacetylguaninyl)-, 1-(N4-phenoxyacetylcytosinyl)-, 1-(N4-tert butyl phenoxyacetylcytosinyl)-, 1-(N4-isopropyl phenoxyacetylcytosinyl)-, and 1-uracilyl-; or
B is a modified nucleoside base radical selected from the consisting of 1-(N4-benzoyl-5-methylcytosinyl)-, 1-(N4-—(N,N-dimethylformamidinyl)-5-methylcytosinyl)-, 1-(N4-acetyl-5-methylcytosinyl)-, 1-(5-methyl-uracilyl)-, 1-(5-fluoro-uracilyl)-, 1-(N4-benzoyl-5-fluorocytosinyl)-, 9-(N6-benzoyl-7-deazaadeninyl)-, 9-(N6—(N,N-dimethylformamidinyl)-7-deazaadenyl)-, 9-(N2-isobutyl-7-deazaguaninyl)-, and 9-(N2—(N,N-dimethylformamidinyl)-7-deazaguaninyl)-;
Z is a member selected from the group consisting of dimethoxy triphenyl (DMT), monomethoxy triphenyl (MMT) and trimethoxy triphenyl (TMT);
(b) placing a phosphoramidite represented by Formula 1 on a oligonucleotide synthesizer;

wherein
Y is an oxygen atom or a sulfur atom;
W is selected from the group consisting of an oxygen diradical, an N—H diradical, and a fluorine radical; and R4 is selected so that:
if W is an oxygen diradical, then R4 is tert butyl dimethyl silyl (TBDMS) or triisopropylsilyl oxymethylene (TOM); and
if W is an N—H diradical, then R4 is of the form R5X, where x is selected from the group consisting of fluorenylmethyloxycarbonyl (Fmoc), trifluoroacetyl, acetyl, alkanoyl and aroyl; and
if W is a fluorine radical, then R4 is not present;
B is selected from the group consisting of nucleoside base radicals consisting of 9-(N6-benzoyladeninyl)-, 9-(N6-acetyladeninyl)-, 9-(N6-tert-butyl phenoxyacetyladeninyl)-, 9-(N6-phenoxyacetyladeninyl)-, 9-(N6-isopropyl phenoxyacetyladeninyl)-, 1-(N6—(N,N-dimethylformamidinyl)adeninyl), 1-(N4-benzoylcytosinyl)-, 1-(N4-acetylcytosinyl)-, 1-(N4—(N,N-dimethylformamidinyl)cytosinyl)-, 1-(N4-phenoxyacetylcytosinyl)-, 1-(N4-tert-butylphenoxyacetylcytosinyl)-, 1-(N4-isopropyl phenoxyacetylcytosinyl)-, 9-(N2-isobutylguaninyl)-, 9-(N2-tert butyl phenoxyacetylguaninyl)-, 9-(N2-isopropyl phenoxyacetylguaninyl)-, 1-(N4-phenoxyacetylcytosinyl)-, 1-(N4-tert butyl phenoxyacetylcytosinyl)-, 1-(N4-isopropyl phenoxyacetylcytosinyl)-, and 1-uracilyl-; or
B is a modified nucleoside base radical selected from the consisting of 1-(N4-benzoyl-5-methylcytosinyl)-, 1-(N4—(N,N-dimethylformamidinyl)-5-methylcytosinyl)-, 1-(N4-acetyl-5-methylcytosinyl)-, 1-(5-methyl-uracilyl)-, 1-(5-fluoro-uracilyl)-, 1-(N4-benzoyl-5-fluorocytosinyl)-, 9-(N6-benzoyl-7-deazaadeninyl)-, 9-(N6—(N,N-dimethylformamidinyl)-7-deazaadenyl)-, 9-(N2-isobutyl-7-deazaguaninyl)-, and 9-(N2—(N,N-dimethylformamidinyl)-7-deazaguaninyl)-;
Z is a member selected from the group consisting of dimethoxy triphenyl (DMT), monomethoxy triphenyl (MMT) and trimethoxy triphenyl (TMT);
R1 is an alkyl or aryl radical;
R2 is an alkyl or aryl radical; and
R3 is cyanoethyl, alkyl or aryl radical;
B is hydrogen or a nucleobase that is optionally functionalized at each primary amine with an amine protecting group;
(c) removing the protecting group Z from the nucleoside solid support represented by Formula 2;
(d) performing the process of RNA synthesis by coupling the nucleoside of Formula 2 and the phosphoramidite of Formula 1 in the oligonucleotide synthesizer using a mixture of ancillary regents to result in an oligonucleotide having at least one protecting group;
(e) providing a phosphoramidite with the L group;
(f) adding the phosphoramidite with the L group at the end of the oligonucleotide to result in an oligonucleotide having the L group;
(g) detaching the oligonucleotide having the L group from the solid support;
(h) removing the at least one protecting group from the oligonucleotide;
(i) removing a silyl protecting group to result in the oligonucleotide;
(j) participating the oligonucleotide; and
(k) analyzing the oligonucleotide for purity determination,
wherein the mixture of ancillary reagent in step (d) comprises phenoxy acetic anhydride/tetrahydrofuran/pyridine), 10% N-methylimidazole/tetrohydrofuran), 3% trichloroacetic acid in toluene, 0.05 M iodine/pyridine/water/tetrahyrofuran and 5-ethylthio-1-H-tetrazole at 0.35 M in acetonitrile.

US Pat. No. 10,167,305

ALLYL COMPLEXES FOR USE IN COUPLING REACTIONS

Johnson Matthey Public Li...

1. A complex of formula (1):
wherein:
M is palladium or nickel;
R1 and R2 are, independently, C1-C20 straight-chain alkyl, C1-C20 branched-chain alkyl, C3-C15 cycloalkyl, C5-C20 aryl, or C3-C20 heteroaryl;
R3 is:
(a) dimethylaminophenyl; or
(b) a substituted metallocenyl of formula (2):

wherein:
R10 is C1-C20 alkyl, C6-C20 aryl, (C1-C20 alkyl)HN—, (C1-C20 dialkyl)N—, (C1-C20 dialkyl)amino-C1-C20-alkyl or C1-C20 alkoxy-C1-C20-alkyl;
R11 is C1-C20 alkyl or C6-C20 aryl;
p is 0, 1, 2, 3 or 4, wherein when p is 2, 3 or 4, each R10 is the same or different;
q is 2, 3, 4 or 5, wherein each R11 is the same or different,
R4 is C1-C20 straight-chain alkyl, C1-C20 branched-chain alkyl, C3-C15 cycloalkyl, C6-C20 aryl, or C5-C20 heteroaryl,
n is 0, 1, 2, 3, 4 or 5; and
X is a halo group,
each alkyl, alkoxy, heteroalkyl, aryl or heteroaryl is optionally substituted with one or more halo, C(halo)3, Ra, ?O, ?S, ORa, SRa, NRaRb, ?NRa, ?N—ORa, CN, SCN, NCS, NO2, C(O)Ra, C(O)ORa, C(S)Ra, C(S)ORa, S(O)2OH, S(O)2Ra, S(O)2NRaRb, OS(O)Ra, or C(O)NRaRb, wherein:
Ra and Rb are, independently, H, C1-20 alkyl, C6-20 aryl, C6-20 aryl-(C1-20alkyl), or C1-20 heteroalkyl, C6-20 heteroaryl, or together with the atom to which they are attached form a C3-15 heterocycloalkyl; and
the heteroatoms in the heteroaryl, heteroalkyl or heterocycloalkyl are sulfur, oxygen, or nitrogen.

US Pat. No. 10,167,304

RUTHENIUM COMPOUND, MATERIAL FOR THIN FILM FORMATION, AND PROCESS FOR THIN FILM FORMATION

ADEKA CORPORATION, Tokyo...

1. A ruthenium compound represented by general formula (I):
wherein R1, R2, and R3 each independently represent a straight or branched chain alkyl group having 1 to 5 carbon atoms, provided that the total number of the carbon atoms of R1 and R2 is 3 to 10.

US Pat. No. 10,167,303

IRIDIUM ORGANOMETALLIC COMPLEX CONTAINING A SUBSTITUTED DIBENZO[F,H]QUINOXALINE AND AN ELECTRONIC DEVICE HAVING AN EMITTING LAYER CONTAINING THE IRIDIUM COMPLEX

UDC IRELAND LIMITED, Dub...

1. A compound of formula:wherein:each La is independently:

wherein:
a) R1 is H, C1-C8 alkyl or C3-C8 cycloalkyl, wherein the C3-C8 cycloalkyl may optionally be substituted by C1-C8 alkyl or C1-C8 perfluoroalkyl;
R2 is H or C1-C8 alkyl;
R3 is C1-C8 alkyl, Si(C1-C8 alkyl)3 or C3-C8 cycloalkyl; and
R8 is C1-C8 alkyl, Si(C1-C8 alkyl)3 or C3-C8 cycloalkyl; or
b) R1 is a group of formula:

wherein:
R4 is C1-C8 alkyl, CF3 or NR7R9;
R4? is C1-C8 alkyl or CF3;
R4?is C1-C8 alkyl or CF3;
R7 is phenyl, 1-naphthyl or 2-naphthyl; and
R9 is phenyl, 1-napthyl or 2-naphthyl; or
R7 and R9, together with the nitrogen atom to which they are bonded, form a group of formula:

wherein:
each R10 is independently H or C1-C8 alkyl; and
R2 is H;
R3 is C1-C8 alkyl, Si(C1-C8 alkyl)3 or C3-C8 cycloalkyl; and
R8 is C1-C8 alkyl, Si(C1-C8 alkyl)3 or C3-C8 cycloalkyl; or
c) R1 and R2 together form a —(CH2)3— ring or —(CH2)4— ring, wherein the —(CH2)3— ring or —(CH2)4— ring may optionally be substituted by one or two C1-C8 alkyl and/or by one or two C1-C8 perfluoroalkyl;
R3 is C1-C8 alkyl, Si(C1-C8 alkyl)3 or C3-C8 cycloalkyl; and
R8 is C1-C8 alkyl, Si(C1-C8 alkyl)3 or C3-C8 cycloalkyl.

US Pat. No. 10,167,302

PHOSPHONATE NUCLEOSIDES USEFUL IN THE TREATMENT OF VIRAL DISEASES

UNIVERSITY COLLEGE CORK, ...

1. A compound of formula (I), or a pharmaceutically acceptable salt, or prodrug thereof selected from a phosphoramidate derivative, a SATE (S-acyl-2-thioethyl) ester derivative, a pivaloyloxymethyl (POM) derivative, an isopropyloxymethylcarbonyl (POC) derivative, a cyclo-saligenyl (cycloSal) derivative and an alkyloxyalkyl derivative,
wherein:
X is selected from O and NR11;
Y is selected from O, S and NR12;
A is selected from —(CR1R2)n-, —(CR9R10)—, —(CR9R10)—(CR1R2)n-, —(CR1R3)—(CR2R4)—(CR1R2)n-, —CR3?CR4—(CR1R2)n- and —C?C—(CR1R2)n-;
R1 and R2 are independently selected from H, alkyl, hydroxyl, hydroxymethyl and halogen;
R3 and R4 are independently selected from H and alkyl, or R3 and R4 together with the carbon atoms to which they are attached form a mono or bicyclic ring system selected from cycloalkyl, cycloalkenyl, heterocycloalkenyl, aryl and heteroaryl;
R5 is selected from H, P(?O)(OH)2 and P(?O)(OH)—O—P(?O)(OH)2;
R6 is selected from H and alkyl;
R7 and R8 are independently selected from H, alkyl, halogen and hydroxymethyl
R9 and R10 together with the carbon atom to which they are attached form a mono or bicyclic ring system selected from cycloalkyl, cycloalkenyl, heterocycloalkyl and heterocycloalkenyl;
R11 is selected from H and alkyl;R12 is selected from H and alkyl;
m is 0, 1, 2 or 3;
n is 1, 2 or 3;
p is 0 or 1;
q is 0, 1, 2 or 3;
r is 0, 1, 2, 3, 4 or 5;
s is 0 or 1;
Base is a natural or non-natural nucleobase; and
wherein each alkyl, cycloalkyl, cycloalkenyl, heterocycloalkyl, heterocycloalkenyl, aryl and heteroaryl may be optionally substituted.

US Pat. No. 10,167,300

METALLOENZYME INHIBITOR COMPOUNDS AS FUNGICIDES

Dow AgroSciences LLC, In...

1. A compound of Formula I, or salt thereof, wherein:
Z is optionally substituted 5-pyrimidinyl, optionally substituted 4-pyrimidinyl, optionally substituted oxazolyl, optionally substituted 3-pyridinyl, optionally substituted 4-pyridinyl, or tetrazolyl;
n is 0 or 1;
R1 is alkyl, alkynyl, haloalkyl, aryl, or heteroaryl, each optionally substituted with 0, 1, 2 or 3 independent R4;
R2 is aryl, heteroaryl aryloxy, heteroaryloxy, arylalkynyl, heteroarylalkynyl, arylalkyl, heteroarylalkyl, arylalkoxy, heteroarylalkoxy, aryloxyalkyl, or heteroaryloxyalkyl wherein each aryl or heteroaryl is optionally substituted with 0, 1, 2 or 3 independent R4;
R3 is independently H, alkyl, aryl, substituted aryl, heteroaryl, arylalkyl, or heteroarylalkyl, —C(O)alkyl, —C(O)aryl, —Si(alkyl)3, each optionally substituted with 0, 1, 2 or 3 independent R4;
R4 is independently aryl, heteroaryl, alkyl, thioalkyl, cyano, haloalkyl, cyanoalkyl, hydroxy, alkoxy, halo, haloalkoxy, —C(O)alkyl, —C(O)OH, —C(O)Oalkyl, —SCF3, —SF5, —SCN, or SO2(alkyl), —Si(alkyl)3, or oxime; and
R5-R7 are independently selected from the group consisting of H, alkyl, alkoxy, halo, and haloalkyl.

US Pat. No. 10,167,299

1-(3-AMINOPROPYL) SUBSTITUTED CYCLIC AMINE COMPOUNDS, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL COMPOSITIONS AND USES THEREOF

SHANGHAI INSTITUTE OF MAT...

1. A compound of formula I, a pharmaceutically acceptable salt, enantiomer, diastereoisomer, racemate or mixture thereof,
wherein,
W is absent or —CH2CH2—;
X is N or CR6;
R1 is selected from a 5 to 7-membered heteroaryl unsubstituted or substituted with 1-3 substituents, wherein said heteroaryl contains 1 to 3 heteroatoms selected from oxygen, sulfur or nitrogen and each of said substituents is independently selected from a halogen, a C1-C4 straight or branched alkyl, a C1-C4 straight or branched haloalkyl, a C1-C4 straight or branched alkyloxy, a C1-C4 straight or branched chain haloalkoxy, —NR10R11, —C(?O)R12, a C1-C4 straight or branched alkanoyloxy, a cyano, a nitro and a hydroxy, or two adjacent R1 substituents with the atoms to which each is attached are combined to form a fused 5-7 membered ring;
each of R10 and R11 is independently selected from a group consisting of H, a C1-C4 straight or branched alkyl and —C(?O)R13;
R12 is selected from a group consisting of a C1-C4 straight or branched alkyl, a C1-C4 straight or branched alkyloxy, a hydroxyl, an amino (NH2) and a C1-C4 straight or branched alkylamino;
R13 is selected from a group consisting of H and a C1-C4 straight or branched alkyl;
R2 is selected from the following groups unsubstituted or substituted with 1-3 substituents: a C1-C6 straight or branched alkyl, a C3-C7 cycloalkyl, a 4 to 7-membered heterocyclic group, a C6-C12 aryl or a 5-7 membered heteroaryl; wherein, said substituent is selected from a group consisting of a halogen, a hydroxy, a C1-C4 straight or branched alkyl, a C1-C4 straight or branched haloalkyl, a C1-C4 straight or branched alkyloxy, a C1-C4 straight or branched alkyl carbonyl, a C1-C4 straight or branched haloalkoxy, a C1-C4 straight or branched alkylsulfonyl group, a C1-C4 straight or branched alkylsulfonylcarbamoyl, a tetrazolyl, a cyano, a nitro, an amino, a carboxy, a phenyl, a halophenyl, a phenoxy, and a halophenoxy;
each of R3, R4 and R5 is independently selected from a group consisting of H, a C1-C6 straight or branched alkyl and a C3-C7 cycloalkyl;
R6 is selected from a group consisting of H and a C1-C6 straight or branched alkyl; alternatively, R5 and R6 may bind together with

 to form

R7 is selected from a group consisting of H, C(?O)R8, C(?O)OR8, C(?O)NR8R9, SO2R8 and the following groups substituted by 1-3 substituents a C1-C6 straight or branched alkyl, a C3-C7 cycloalkyl, a 4 to 7-membered heterocyclic group, a benzyl, a C6-C12 aryl and a 5-7 membered heteroaryl; wherein said substituent is selected from a halogen, a hydroxy, a C1-C4 straight or branched alkyloxy, a C1-C4 straight or branched alkyl, a C1-C4 straight or branched haloalkyl, a C1-C4 straight or branched haloalkoxy, a cyano, a nitro, an amino and a carboxyl;
each of R8 and R9 is independently selected from a group consisting of a hydrogen and the following groups unsubstituted or substituted with 1-3 substituents: a C1-C6 straight or branched alkyl, a C3-C7 cycloalkyl, a 4-7 membered heterocyclic group, a benzyl, a C6-C12 aryl and a 5-7 membered heteroaryl; wherein said substituent is selected from a group consisting of a halogen, a hydroxy, a C1-C4 straight or branched alkoxy, a C1-C4 straight or branched alkyl, a C1-C4 straight or branched haloalkyl, a C1-C4 straight or branched haloalkoxy, a cyano, a nitro, an amino, and a carboxyl.

US Pat. No. 10,167,298

PSEUDOPOLYMORPHS OF AN HCV NS5A INHIBITOR AND USES THEREOF

1. A crystalline form of the compound having the structure:
wherein said crystalline form is selected from the following forms: Form A (methanolate), Form B (ethanolate), Form C (1-propanolate), Form D (2-propanolate), Form E (acetonate), Form F (1-butanolate), Form G (ethylene glycolate), Form H (propylene glycolate), Form I (methyl isobutyl ketone/propylene glycol mixed solvate), Form J (hydrate) and Form K (1,5-naphthalene disulfonic acid salt).

US Pat. No. 10,167,297

SUBSTITUTED PYRIDINE COMPOUNDS HAVING HERBICIDAL ACTIVITY

BASF SE, Ludwigshafen (D...

1. A compound of the formula I
wherein
R is hydroxyl or O—RA where RA is C1-C-8-alkyl, C2-C8-alkenyl, C2-C8-alkynyl, C1-C8-alkylcarbonyl-, C3-C6-cycloalkylcarbonyl-, C1-C8-alkoxycarbonyl-, C1-C8-alkylthiocarbonyl-, C1-C8-alkoxycarbonyloxy-C1-C3-alkyl-, C1-C8-alkylcarbonyloxy-C1-C3-alkyl-, tri(C1-C4-alkyl)silyl-, C1-C8-alkyl-S(O)n—, aryl-S(O)n—, aryl-C1-C4-alkyl- or arylcarbonyl-, where the aryl moiety is unsubstituted or substituted by one to five Ra and each Ra is independently halogen, nitro, cyano, C1-C8-alkyl, C1-C6-haloalkyl, C1-C8-alkoxy, C1-C8-haloalkoxy, or C1-C4-alkyl-S(O)n—;
R1 and R2 independently of one another are halogen, cyano, nitro, C1-C6-alkyl, C3-C6-cycloalkyl, C1-C6-haloalkyl, C1-C6-alkoxy, C1-C6-haloalkoxy, C1-C6-alkoxy-C1-C4-alkyl-, C1-C6-haloalkoxy-C1-C4-alkyl-, C3-C6-cycloalkyl-C1-C3-alkyl-, C3-C6-cycloakyl-C1-C3-alkoxy-, C1-C6-alkoxy-C2-C6-alkoxy-, C1-C6-alkoxy-C2-C6-alkoxy-C1-C3-alkyl-, C1-C6-alkylthio-, C1-C6-haloalkylthio-, C1-C6-alkylsulfonyl-, C1-C6-haloalkylsulfonyl-, C1-C3-alkylaminosulfonyl-, C1-C3-dialkylaminosulfonyl-, C1-C3-alkylamino-sulfonyl-C1-C3-alkyl-, C1-C3-dialkylamino-sulfonyl-C1-C3-alkyl-, C1-C3-alkylcarbonylamino-, N—C1-C3-alkyl-N—C1-C3-alkylcarbonylamino-, C1-C3-alkylsulfonylamino-, N—C1-C3-alkyl-N—C1-C3-alkylsulfonylamino-, C1-C3-alkylsulfonylamino-C1-C3-alkyl-, C1-C3-alkylaminocarbonyl-C1-C3-alkyl-, C1-C3-dialkylaminocarbonyl-C1-C3-alkyl-, N—C1-C3-alkylcarbonyl-N—C1-C3-alkylamino-C1-C3-alkyl-, N—C1-C3-alkylsulfonyl-N—C1-C3-alkylamino-C1-C3-alkyl-, C1-C3-alkylcarbonylamino-C1-C3-alkyl-, Z-heterocyclyl or Z-heterocyclyloxy wherein said heterocyclyls are 5- or 6-membered heterocyclyls containing 1, 2 or 3 heteroatoms selected from the group consisting of O, N and S, and are unsubstituted or partially or fully substituted by substituents selected from the group consisting of halogen, C1-C3-alkyl, C3-C6-cycloalkyl, C1-C3-haloalkyl, C1-C3-alkoxy, C1-C3-haloalkoxy, C1-C6-alkyl-S(O)n—, cyano, nitro and phenyl;
R3 is hydrogen;
R4 is hydrogen or halogen;
R5, R6, and R7 independently of one another are hydrogen, halogen or C1-C4-alkyl;
Rx, Ry independently of one another are hydrogen, C1-C5-alkyl, C2-C5-alkenyl, C2-C5-alkynyl, C1-C5-haloalkyl, C1-C2-alkoxy-C1-C2-alkyl- or halogen; or
Rx and Ry are together a C2-C5-alkylene or C2-C5-alkenylene chain and form a 3-, 4-, 5- or 6-membered saturated, partially unsaturated or fully unsaturated monocyclic ring together with the carbon atom they are bonded to, wherein 1 or 2 of any of the CH2 or CH groups in the C2-C5-alkylene or C2-C5-alkenylene chain may be replaced by 1 or 2 heteroatoms independently selected from O or S;
R8 is H, C1-C4-alkyl, C1-C4-haloalkyl, C1-C4-alkoxy-C1-C4-alkyl, C3-C6-cycloalkyl or C2-C6-alkenyl;
R9 is C1-C4-alkyl, C1-C4-haloalkyl, C1-C6-alkoxy-, hydroxy-C1-C4-alkyl, C1-C6-haloalkoxy, C1-C6-alkoxy-C1-C4-alkyl-, C1-C6-alkoxy-C2-C6-alkoxy-, C1-C6-alkoxy-C2-C6-alkoxy-C1-C3-alkyl-, C3-C6-cycloalkyl, C1-C3-alkyl-C3-C6-cycloalkyl-, C3-C6-cycloalkyl-C1-C3-alkyl-, C3-C6-cycloalkyloxy-, C3-C6-cycloakyl-C1-C3-alkoxy-, C2-C6-alkenyl, C2-C6-alkenyloxy-, amino, C1-C4-alkylamino-, C2-C6-alkenylamino, C1-C4-dialkylamino-, C3-C6-cycloalkylamino-, or aryl being unsubstituted or substituted by one to five Ra and each Ra being independently selected from the group consisting of halogen, nitro, cyano, C1-C8-alkyl, C1-C6-haloalkyl, C1-C8-alkoxy, C1-C8-haloalkoxy and C1-C4-alkyl-S(O)n—; or R9 is a nitrogen-containing ring selected from the group consisting of aziridine, azetidine, pyrrolidine and piperidine, wherein each of said nitrogen-containing rings is bonded via its nitrogen atom to the carbon atom of the N—C?O group;
or R8 and R9 form together with the N—C?O group to which they are attached a heterocyclic ring of the formula (A1) or (A2)

wherein
each # denotes the bonding site to the remainder of the formula I;
X1, X3, X4, X5 and X7 are independently from one another O or CR10R11 with the proviso that only one of X1 and X3 in the formula (A1) and only one of X4, X5 and X7 in the formula (A2) is O;
X2 and X6 are CR10R11, and wherein R10 and R11 in each of the aforementioned groups CR10R11 are independently of one another hydrogen or C1-C4-alkyl;
Z is independently a covalent bond or C1-C4-alkylene;
n is independently 0, 1 or 2;
or an agriculturally suitable salt or N-oxide thereof.

US Pat. No. 10,167,296

SULFOXIMINE SUBSTITUTED QUINAZOLINES FOR PHARMACEUTICAL COMPOSITIONS

EVOTEC INTERNATIONAL GMBH...

1. A compound of formula (I)
wherein
Ar is selected from the group consisting of:

wherein X is CH or N;
R5 is H, halogen or CN; and
R4 is selected from the group consisting of C1-6-alkyl, C3-7-cycloalkyl, heterocyclyl, —(CH2)1-3—C(?O)—NH—(C1-5-alkyl) and —(CH2)1-3—C(?O)—N(CH3)—(C1-5-alkyl);
wherein each alkyl or cycloalkyl group of R4 is optionally substituted with one or more F or one CN, OH or CF3;
wherein each heterocyclyl is optionally substituted with one or more F and/or one OH or —O—(C1-3-alkyl); or
R4 is selected from the group consisting of:

R1 is halogen, C1-3-alkyl or —O—(C1-3-alkyl);
R2 is selected from the group consisting of OH, —O—(C1-6-alkyl), —O—(CH2)1-3—(C3-7-cycloalkyl), —O—(CH2)1-3—O—(C1-3-alkyl), —O-heterocyclyl and —O—(CH2)2-4-heterocyclyl,
wherein in the definition of R2, each heterocyclyl is optionally substituted with one C1-3-alkyl group, and wherein one CH2 group of said heterocyclyl of R2 may be replaced with a carbonyl group;
R3 is selected from the group consisting of:

wherein R6 is C1-2-alkyl;
R7 is C1-5-alkyl, C3-7-cycloalkyl or heterocyclyl,
wherein the alkyl group of R7 is optionally substituted with one or more F or with one OH or —O—(C1-3-alkyl), and
wherein the heterocyclyl group of R7 is tetrahydropyranyl; and
or wherein R6 and R7 together with the sulfur atom to which they are attached form a 4- to 7-membered saturated or partly unsaturated heterocycle that may be substituted in any position not adjacent to the sulfur atom by one or two F, OH or —O—(C1-3-alkyl) or by one or two C1-3-alkyl and that further to the sulfur atom may contain one additional heteroatom selected from the group consisting of O, S and NRN,
wherein RN is H or C1-3-alkyl,
wherein, if not otherwise specified, each alkyl group in the above definitions is linear or branched and may be substituted with one to three F;or a salt thereof.

US Pat. No. 10,167,295

ANALGESIC COMPOUNDS AND METHODS OF USE

The Regents of the Univer...

1. A method of producing sexually dimorphic analgesia in a male subject in need thereof, the method comprising administering to the male subject a therapeutically effective amount of a compound having the formula:
or a pharmaceutically acceptable salt thereof; wherein R4 is hydrogen or methyl; R5 is —C(O)-L1-R3; L1 is a bond, —CH2—, —CH2CH2—, or —CH2CH2CH2—; and R3 is (i) an unsubstituted 5-membered heterocyloalkyl; (ii) an unsubstituted 6-membered heterocycloalkyl; (iii) a 5-membered heterocyloalkyl substituted with one or two substituents selected from the group consisting of ?O, halogen, —OH, —NH2, —SH, —C(O)OH, —C(O)NH2, —CF3, —CCl3, —CN, —N3, an unsubstituted C1-C8 alkyl, and benzyl; or (iv) a 6-membered heterocycloalkyl.

US Pat. No. 10,167,294

FUSED BICYCLIC COMPOUNDS FOR THE TREATMENT OF DISEASE

Akarna Therapeutics, Ltd....

1. A compound according to Formula (IV), or a pharmaceutically acceptable salt or solvate thereof:
wherein:
R1 is selected from the group consisting of hydrogen, optionally substituted C1-C6alkyl, optionally substituted C2-C6alkenyl, optionally substituted C2-C6alkynyl, optionally substituted C3-C8cycloalkyl, optionally substituted aryl, optionally substituted —(C1-C2alkylene)-(aryl), optionally substituted C2-C9heterocycloalkyl, optionally substituted heteroaryl, and optionally substituted —(C1-C2alkylene)-(heteroaryl);
R2 is selected from the group consisting of —CN, —C(O)OR25, —C(O)N(R25)R26,

 or R1 and R2 together with the carbon atoms to which they are attached, form an optionally substituted C2-C9heterocycloalkyl ring or an optionally substituted heteroaryl ring;
R4 and R5 are each independently selected from the group consisting of hydrogen, halogen, optionally substituted C1-C6alkoxy, optionally substituted C1-C6alkyl, optionally substituted C2-C6alkenyl, and optionally substituted C2-C6alkynyl; or R4 and R5 together with the carbon atom to which they are attached, form an optionally substituted C3-C6cycloalkyl ring or an optionally substituted C2-C7heterocycloalkyl ring;
R6 is selected from the group consisting of hydrogen, halogen, optionally substituted C1-C6alkyl, optionally substituted C2-C6alkenyl, optionally substituted C2-C6alkynyl, and —C(O)N(R27)R28;
R7 is selected from the group consisting of hydrogen, halogen, optionally substituted C1-C6alkyl, optionally substituted C1-C6alkoxy, optionally substituted C2-C6alkenyl, and optionally substituted C2-C6alkynyl;
R8 is selected from the group consisting of hydrogen, optionally substituted C1-C6alkyl, optionally substituted C3-C8cycloalkyl, optionally substituted aryl, optionally substituted —(C1-C2alkylene)-(aryl), optionally substituted heteroaryl, optionally substituted C2-C9heterocycloalkyl, and optionally substituted —(C1-C2alkylene)-(heteroaryl);
each R12 is independently selected from the group consisting of hydrogen and C1-C6alkyl;
each R13 and R14 are each independently selected from the group consisting of hydrogen and C1-C6alkyl; or R13 and R14 together with the nitrogen atom to which they are attached, form an optionally substituted C2-C9heterocycloalkyl ring;
each R15 is independently selected from the group consisting of halogen, —OH, —CN, —NO2, —NH2, optionally substituted C1-C6alkyl, optionally substituted C1-C6alkoxy, optionally substituted C1-C6alkylamine, optionally substituted C3-C8cycloalkyl, optionally substituted C2-C9heterocycloalkyl, aryl, heteroaryl, —C(O)OR12, —C(O)N(R13)R14, —OC(O)OR12, —OC(O)N(R13)R14, —N(R13)C(O)OR12, and —N(R13)C(O)N(R13)R14;
R25 and R26 are each independently selected from the group consisting of hydrogen, optionally substituted C1-C6alkyl, optionally substituted C3-C8cycloalkyl, optionally substituted aryl, optionally substituted —(C1-C2alkylene)-(aryl), optionally substituted C2-C9heterocycloalkyl, optionally substituted heteroaryl, and optionally substituted —(C1-C2alkylene)-(heteroaryl);
R27 and R28 are each independently selected from the group consisting of hydrogen, optionally substituted C1-C6alkyl, optionally substituted C3-C8cycloalkyl, optionally substituted aryl, optionally substituted —(C1-C2alkylene)-(aryl), optionally substituted C2-C9heterocycloalkyl, optionally substituted heteroaryl, and optionally substituted —(C1-C2alkylene)-(heteroaryl); or R27 and R28 together with the nitrogen atom to which they are attached, form an optionally substituted C2-C9heterocycloalkyl ring;
R30 is halogen, —OH, —CN, —NO2, —NH2, optionally substituted C1-C6alkyl, optionally substituted C1-C6alkoxy, optionally substituted C1-C6alkylamine, optionally substituted C3-C8cycloalkyl, optionally substituted C2-C9heterocycloalkyl, aryl, heteroaryl,

each R31 is independently halogen, —OH, —CN, —NO2, —NH2, optionally substituted C1-C6alkyl, optionally substituted C1-C6alkoxy, optionally substituted C1-C6alkylamine, optionally substituted C3-C8cycloalkyl, optionally substituted C2-C9heterocycloalkyl, aryl, or heteroaryl;
each R32 and R33 are each independently selected from the group consisting of hydrogen, halogen, and C1-C6alkyl;
R34 and R35 are each independently selected from the group consisting of hydrogen, optionally substituted C1-C6alkyl, optionally substituted C3-C8cycloalkyl, and optionally substituted C2-C9heterocycloalkyl; or R34 and R35 together with the nitrogen atom to which they are attached, form an optionally substituted C2-C9heterocycloalkyl ring;
n is 0, 1, 2, or 3
p is 0, 1, 2, 3, or 4;
r is 0, 1, 2, 3, or 4; and
t is 2, 3, or 4.

US Pat. No. 10,167,292

BENZODIAZEPINES AS BROMODOMAIN INHIBITORS

Catalyst Therapeutics Pty...

1. A compound of Formula I or a pharmaceutically acceptable derivative, polymorph, salt or prodrug thereof
wherein:
R1 is selected from the group consisting of H, C1-4alkyl, CF3, CF2H, C1-4alkylXH, C1-4alkylOCOR5; wherein X?O, S;
R2 is 0-3 substituents independently selected from the group consisting of C1-4alkyl, CN, Cl, Br, I, C3-10heterocyclyl, OC1-4alkyl, C5-10heteroaryl, C1-4alkylC6-10aryl, C1-4alkylC5-10heteroaryl, hydroxyl, nitro, COR6, CO2R6, CONR5R6, CONHSO2R5, SO2NHCOR5, CONR5OR6, C1-4alkylNR5R6, C1-4alkylOR6, NR5R6, NR5COR6, NR7CONR5R6 and NR5CO2R6;
R3 is selected from the group consisting of C1-4alkyl, C3-10cycloalkyl, C3-10heterocyclyl, C6-10aryl, C1-4alkylC6-10 aryl;
R4 is 1 to 2 groups on the same or adjacent carbons selected from oxo, C1-4alkyl, C1-4alkylOH, C1-4alkylOCOR5, C1-4alkylCONR5R6, C1-4alkylC6-10aryl, C1-4alkylC5-10heteroaryl;
R5 and R6 are independently selected from the group consisting of hydrogen, C1-4alkyl, C3-10cycloalkyl, C3-10heterocyclyl, C6-10aryl, C5-10heteroaryl, C1-4alkylC6-10aryl and C1-4alkylC5-10heteroaryl;
alternatively R5 and R6 are bound to the same atom and form an optionally substituted ring that is 4 to 10 carbon atoms in size wherein optionally one or more carbon atoms are replaced with O, S, S(O), SO2, or NR7; and
R7 is selected from the group consisting of hydrogen and C1-4alkyl
and further wherein, unless otherwise stated, each alkyl, cycloalkyl, heterocycyl, heteroaryl, and aryl is optionally substituted.

US Pat. No. 10,167,290

SUBSTITUTED PYRAZINO[2,3-B]PYRAZINES AS MTOR KINASE INHIBITORS

Signal Pharmaceuticals, L...

1. A method for preparing a compound of formula (II):
the method comprising contacting a compound of formula (VI):

with R1—Y in a solvent, in the presence of a palladium catalyst, wherein said contacting occurs in the presence of a base,
wherein Y is B(OR+)2 or Sn(R++)3;
R1 is substituted or unsubstituted C1-8 alkyl, substituted or unsubstituted aryl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocyclyl, or substituted or unsubstituted heterocyclylalkyl;
R2 is H, substituted or unsubstituted C1-8 alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted heterocyclylalkyl, substituted or unsubstituted aralkyl, or substituted or unsubstituted cycloalkylalkyl;
R3 is H, or a substituted or unsubstituted C1-8 alkyl; and
each R+ is hydrogen, or each R+, together with the boron atom and the atoms to which they are attached, form a cyclic boronate;
each R++ is independently C1-3 alkyl;
the palladium catalyst is bis(dibenzylideneacetone)palladium(0)/tri-o-tolylphosphine, or palladium (II) acetate/4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; and
substituted means substituted with a substituent selected from the group consisting of chloro; iodo; bromo; fluoro; alkyl; hydroxy; alkoxy; alkoxyalkyl; amino; alkylamino; carboxy; nitro; cyano; thiol; thioether; imine; imide; amidine; guanidine; enamine; aminocarbonyl; acylamino; phosphonato; phosphine; thiocarbonyl; alkylsulfonyl; sulfonamide; acyl; ester; urea; urethane; oxime; hydroxylamine; alkoxyamine; aralkoxyamine; N-oxide; hydrazine; hydrazide; hydrazone; azide; isocyanate; isothiocyanate; cyanate; thiocyanate; oxo; B(OH)2, O(alkyl)aminocarbonyl; cycloalkyl, which may be monocyclic or fused or non-fused polycyclic, or a heterocyclyl, which may be monocyclic or fused or non-fused polycyclic; monocyclic or fused or non-fused polycyclic aryl or heteroaryl; aryloxy; aralkyloxy; heterocyclyloxy; and heterocyclylalkoxy.

US Pat. No. 10,167,289

PYRAZOLOPYRIMIDINE COMPOUNDS

University Health Network...

1. A method for treating cancer, the method comprising administering to a subject in need thereof an effective amount of a compound represented by the following structural formula:or a pharmaceutically acceptable salt thereof, wherein the cancer is pancreatic cancer, prostate cancer, lung cancer, melanoma, colon cancer, ovarian cancer, hepatocellular carcinoma, mesothelioma, leukemia, lymphoma or glioblastoma multiform.

US Pat. No. 10,167,288

SUBSTITUTED PYRAZOLYLPYRAZOLE DERIVATIVE AND USE OF SAME AS HERBICIDE

KYOYU AGRI CO., LTD., Ka...

1. A compound represented by the following formula (I):wherein,R1 represents a chlorine atom or bromine atom,
R2 represents a cyano group,
R3 represents a hydrogen atom or C1-C6 alkyl group which may be optionally substituted with one or more halogen atoms,
R4 represents a C1-C6 alkyl group which may be optionally substituted with one or more halogen atoms, a C3-C6 alkenyl group which may be optionally substituted with one or more halogen atoms, or a C3-C6 alkynyl group which may be optionally substituted with one or more halogen atoms,
a represents 3 to 5, and
X represents an oxygen atom or sulfur atom.

US Pat. No. 10,167,287

SUBSTITUTED PYRIMIDINE COMPOUNDS AND METHODS OF USE AND MANUFACTURE

Duquesne University of th...

1. A method of treating a patient having cancer selected from the group consisting of Malignant Pleural Mesothelioma and Non-Small Cell Lung Cancer, comprising administering to the patient an effective amount of a compound of a formula:
wherein X is O and n is three, and optionally comprising a pharmaceutically acceptable salt, hydrate, or solvate thereof, and including optionally administering an effective amount of said salt, hydrate, or solvate of said compound to said patient.

US Pat. No. 10,167,286

COMPOSITIONS AND METHODS USING THE SAME FOR TREATMENT OF NEURODEGENERATIVE AND MITOCHONDRIAL DISEASE

Mitokinin, Inc., New Yor...

1. A compound comprising the following formula or pharmaceutically acceptable salt thereof:
wherein X is independently selected from a C—H, C—CH3, C—CH2CH3, C—CH2CH2CH3, or CR3, wherein R3 is independently selected from a substituted or unsubstituted cycloalkyl, a substituted or unsubstituted heterocycloalkyl, a substituted or unsubstituted aryl, or a substituted or unsubstituted heteroaryl;
L1 is a bond, substituted or unsubstituted alkylene, or substituted or unsubstituted heteroalkylene;
R1 is hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; and R4 is hydrogen, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
R2 is N;
R5 is CH, CCH3, or CC6H5; and
R6 is N;
wherein the compound does not comprise kinetin or cytokinin.

US Pat. No. 10,167,285

SMALL-MOLECULE HSP90 INHIBITORS

Memorial Sloan Kettering ...

1. A compound of the formula:or a salt thereof,wherein the right side aryl ring optionally comprises one or more heteroatoms which are N or O, R is an amino alkyl moiety, optionally substituted on the amino nitrogen with one or two carbon-containing substituents selected independently from the group consisting of alkyl, alkenyl and alkynyl substituents, wherein the total number of carbons in the amino alkyl moiety is from 1 to 9;
X4 is hydrogen or halogen, wherein the halogen is F or Cl, or Br;
X3 is CH2, CF2, S, SO, SO2, O, NH, or NR2, wherein R2 is alkyl; and
X2 is halogen, alkyl, alkoxy, halogenated alkoxy, hydroxyalkyl, pyrollyl, optionally substituted aryloxy, alkylamino, dialkylamino, carbamyl, alkylamido, dialkylamido, acylamino, alkylsulfonylamido, trihalomethoxy, trihalocarbon, thioalkyl, SO2-alkyl, COO-alkyl, NH2, OH, or CN;
X1 has the formula —O—(CH2)n—O—, wherein n is 1 or 2, and one of the oxygens is bonded at the 5?-position of the aryl ring and the other at the 4?-position of the aryl ring; and
the compound comprises a radiolabeled atom.

US Pat. No. 10,167,284

SPIROCYCLIC COMPOUNDS AS AGONISTS OF THE MUSCARINIC M1 RECEPTOR AND/OR M4 RECEPTOR

Heptares Therapeutics Lim...

1. A compound of the formula (1):
or a salt thereof, wherein:
p is 0, 1 or 2;
q is 1 or 2;
r is 1 or 2;
s is 1 or 2, where the total of r and s is 2 or 3;
X is C or N;
Z is CH2, N, O or S;
Y is NH, O, S or CH2;
R1 can be H, halo, CN, OH, C1-3 alkoxy, NH2, optionally substituted C1-6 alkyl, optionally substituted C2-6 alkenyl, optionally substituted C2-6 alkynyl, optionally substituted C3-6 cycloalkyl, optionally substituted C3-6 cycloalkenyl, W or CH2—W where W is an optionally substituted 5 or 6 membered cycloalkyl, heterocycloalkyl, aryl or heteroaryl ring, NR5R6, COOR5, CONR5R6, NR7CONR5R6, NR7COOR5, OCONR5R6, SR5, SOR5, SO2R5 or SO3R5;
R2 can be independently H, halo, CN, OH, C1-3 alkoxy, NH2, optionally substituted C1-6 alkyl, optionally substituted C2-6 alkenyl, optionally substituted C2-6 alkynyl, optionally substituted C3-6 cycloalkyl, optionally substituted C3-6 cycloalkenyl, W or CH2—W where W is an optionally substituted 5 or 6 membered cycloalkyl, heterocycloalkyl, aryl or heteroaryl ring, NR5R6, COOR5, CONR5R6, NR7CONR5R6, NR7COOR5, OCONR5R6, SR5, SOR5 or SO2R5; or R1 and R2 together form an optionally substituted cycloalkyl or heterocycloalkyl ring;
R3 can be independently H, optionally substituted C1-6 alkyl, optionally substituted C2-6 alkenyl, optionally substituted C2-6 alkynyl, optionally substituted C3-6 cycloalkyl, optionally substituted C3-6 cycloalkenyl, W or CH2—W where W is an optionally substituted 5 or 6 membered cycloalkyl, heterocycloalkyl, aryl or heteroaryl ring; or R3 and R2 together form an optionally substituted cycloalkyl or heterocycloalkyl ring;
R4 can be H, optionally substituted C1-5 alkyl, optionally substituted C2-5 alkenyl, optionally substituted C2-5 alkynyl, optionally substituted C3-6 cycloalkyl or optionally substituted C3-6 cycloalkenyl; and
R5, R6 and R7 can be independently H or C1-6 alkyl.

US Pat. No. 10,167,283

?-LACTAMASE INHIBITORS AND USES THEREOF

SUANZHU PHARMA CO., LTD.,...

1. A compound of Formula (I), a pharmaceutically acceptable salt, ester, solvate or stereoisomer thereof:
wherein,
R1 is —SO3M, —OSO3M, —SO2NH2, —PO3M, —OPO3M, —CH2CO2M, —CF2CO2M or CF3;
M is selected from H or a pharmaceutically acceptable cation;
Ring A is selected from the group consisting of 5- to 15-membered bridged cyclyl, 5- to 15-membered spiro cyclyl, 5- to 15-membered bridged heterocyclyl or 5- to 15-membered spiro heterocyclyl, which is optionally substituted with substituent(s) selected from the group consisting of halogen, amino, carboxyl, hydroxyl, cyano, C1-6 alkyl, halo C1-6 alkyl, C1-6 alkoxy, C1-6 alkylamino or C1-6 alkylcarbonyl;
R2 is selected from the group consisting of hydrogen atom, halogen, amino, carboxyl, hydroxyl, C1-6 alkyl, halo C1-6 alkyl, hydroxylC1-6 alkyl, C1-6 alkoxy, C1-6 alkoxyC1-6 alkyl, halo C1-6 alkoxy, halo C1-6 alkoxyC1-6 alkyl, C1-6 alkylamino, di(C1-6 alkyl)amino, C1-6 alkylaminoC1-6 alkyl, C1-6 alkylcarbonyl, halo C1-6 alkylcarbonyl, halo C1-6 alkylcarbonylC1-6 alkyl, C1-6 alkylcarbonyloxy, C1-6 alkoxycarbonyl, C1-6 alkylcarbonyloxyC1-6 alkyl, C1-6 alkylacylamino, C1-6 alkylaminocarbonyl, di(C1-6 alkyl)aminocarbonyl, C1-6 alkylsulfinyl, C1-6 alkylsulfonyl, C1-6 alkylsulfonylC1-6 alkyl, C1-6 alkylsulfonylamino, C1-6 alkylsulfonyloxy, C2-6 alkenyl, C2-6 alkynyl, 3- to 8-membered cycloalkyl, 3- to 8-membered cycloalkyl-C1-6 alkyl, 6- to 8-membered aryl, 6- to 15-membered fused aryl, 4- to 15-membered fused cyclyl, 5- to 15-membered bridged cyclyl, 5- to 15-membered Spiro cyclyl, 3- to 8-membered heterocyclyl, 3- to 8-membered heterocyclyl-C1-6 alkyl, 5- to 8-membered heteroaryl, 5- to 15-membered fused heteroaryl, 4- to 15-membered fused heterocyclyl, 5- to 15-membered bridged heterocyclyl or 5- to 15-membered Spiro heterocyclyl.

US Pat. No. 10,167,282

1-(5-TERT-BUTYL-2-ARYL-PYRAZOL-3-YL)-3-[2-FLUORO-4-[(3-OXO-4H-PYRIDO [2, 3-B]PYRAZIN- 8-YL)OXY]PHENYL]UREA DERIVATIVES AS RAF INHIBITORS FOR THE TREATMENT OF CANCER

CANCER RESEARCH TECHNOLOG...

1. A method of treating a disorder comprising administering to a subject in need of treatment thereof a therapeutically-effective amount of a compound selected from compounds of the following formulae and pharmaceutically acceptable salts and N-oxides thereof:
wherein the disorder is:
malignant melanoma; colorectal carcinoma; metastatic colorectal carcinoma; follicular thyroid cancer; insular thyroid cancer; papillary thyroid cancer; ovarian carcinoma; low grade ovarian carcinoma; non-small cell lung cancer; hairy cell leukemia; cholangiocarcinoma; pediatric low-grade glioma; pilocytic astrocytoma; ganglioglioma; pleomorphic xanthoastrocytoma; multiple myeloma; medullary carcinoma of the pancreas; pancreatic ductal adenocarcinoma; pancreatic cancer; non-small cell lung cancer; ovarian neoplasms; peritoneal neoplasms; fallopian tube neoplasms; lung cancer and associated pleural effusion; recurrent or metastatic squamous cell cancer of the head and neck; locally advanced nasopharyngeal carcinoma; glioblastoma; glioblastoma multiforme; giant cell glioblastoma; gliosarcoma; diffuse intrinsic pontine glioma; HIV-related kaposi sarcoma; multiple myeloma; renal cell carcinoma; metastatic gastric adenocarcinoma; acute myeloid leukemia; hepatocellular carcinoma; dermatofibrosarcoma; medullary thyroid cancer; papillary thyroid cancer; follicular thyroid cancer; myelodysplastic syndrome; neurofibromatosis type 1; plexiform neurofibroma; spinal cord neurofibroma; breast cancer; biliary tract neoplasms; cervical cancer; prostate cancer; melanoma; bladder carcinoma; urethra carcinoma; ureter carcinoma; renal carcinoma; pelvis carcinoma; sarcoma; liposarcoma; colon cancer; osteosarcoma; synovial carcinoma; neuroblastoma; or rhabdomyosarcoma.

US Pat. No. 10,167,281

SUBSTITUTED THIAZOLE OR OXAZOLE P2X7 RECEPTOR ANTAGONISTS

Axxam S.P.A., Bresso (MI...

1. A method of treating conditions or diseases selected from Alzheimer's Disease, Lewy body dementia, fronto-temporal dementia, taupathies, amyotrophic lateral sclerosis, multiple sclerosis, Parkinson's Disease and parkinsonian syndromes, Huntington's disease, Charcot-Marie-Tooth disease; head trauma, cerebral ischemia, meningitis, cognitive psychiatric disorders; sleep disorders; neuropathic and inflammatory pain, chronic pain, migraine, multiple sclerosis pain, HIV-related neuropathy, HIV-induced neuroinflammation and CNS damage, epilepsy and status epilepticus, inflammatory processes of the musculoskeletal system, liver fibrosis, gastrointestinal tract disorders genito-urinary tract disorders, ophthalmic diseases, chronic obstructive pulmonary disease (COPD), autoimmune diseases nephritis, in a mammal in need thereof:said method comprising:
administering a therapeutically effective amount of a compound of the following Formula (I) or a pharmaceutically acceptable salt thereof:

including any stereochemically isomeric form thereof, wherein
n is 1 or 2;
Y represents oxygen or sulfur;
each of R1 and R2 is independently selected from the group consisting of hydrogen, deuterium, halogen, C1-C4 alkyl, optionally substituded with hydroxy or halogen, such as hydroxymethyl, fluoromethyl, difluoromethyl, trifluoromethyl, C3-C6 cycloalkyl, optionally substituded with hydroxy or halogen, or C1-C4 alkyloxy; each of R3 and R4 is independently selected from the group consisting of hydrogen, halogen, C1-C4 alkyl, difluoromethyl, trifluoromethyl, C1-C4 alkyloxy, NR9R10, wherein R9 and R10 independently are hydrogen or C1-C4 alkyl, or 2-thiazolidin-1,1-dione; or the two R3 groups or the R3 and R4 groups taken together form a six membered heterocyclic ring containing a nitrogen atom;
R5 is selected from hydrogen, halogen, or is an heterocyclic ring selected from pyrimidin-2-yl, pyridin-2-yl or pyrazin-2-yl, optionally substituted with halogen, C1-C4 alkyl, fluoromethyl, difluoromethyl, trifluoromethyl or C1-C4 alkyloxy;
R7 is hydrogen or C1-C4 alkyl;
the radical

represents an optionally substituted azetidine, pyrrolidine, piperidine, morpholine, oxazepane or 1,2,3,4-tetrahydroisoquinoline ring, wherein each of R6 is independently selected from the group consisting of hydrogen, halogen, C1-C4 alkyl, C3-C6 cycloalkyl, C3-C6 spirocycloalkyl difluoromethyl, trifluoromethyl, C1-C4 alkyloxy, aryl, heteroaryl, C1-C4 aryloxy or C1-C4 arylalkoxy wherein the aryl group or heteroaryl group is optionally substituted with halogen C1-C4 alkyl, fluoromethyl, difluoromethyl, trifluoromethyl or C1-C4 alkyloxy,
to said mammal; and
treating said conditions or diseases in a mammal in need thereof.

US Pat. No. 10,167,279

COMPOUNDS AND COMPOSITIONS AS RAF KINASE INHIBITORS

Novartis AG, Basel (CH)

1. A compound, or a pharmaceutically acceptable salt thereof, of formula I or II:in which:L is selected from NHC(O)— and —C(O)NH—;
Y1 is selected from N and CH;
Y2 is selected from N and CH;
Y3 is selected from N and CH;
Y4 is selected from N and CR8; wherein R8 is selected from H, hydroxy-ethoxy, 3-hydroxyoxetan-3-yl, 2,3-dihydroxypropoxy, bis(hydroxy-ethyl)-amino, 4-hydroxy-piperidin1-yl, hydroxy-ethyl-amino, 4-amino-4-methylpiperidin-1-yl, 2-oxooxazolidin-3-yl, methoxy and methyl;
Y5 is selected from N and CR1;
or R1 and the nitrogen of Y4 form a 5 member unsaturated ring containing and additional heteroatom selected from N, O and S;
or R1 and R8 together with the ring to which they are both attached form 2H-benzo[b][1,4]oxazin-3(4H)-one substituted with one to two R20 groups independently selected from methyl and hydroxy-ethyl;
or R8 and Y3 together with the ring to which they are both attached form 1H-benzo[d]imidazole substituted with methyl;
R1 is selected from H, ethoxy, isopropoxy, methoxy-ethyl-amino, (2-hydroxyethyl)(methyl)amino, (1-hydroxypropan-2-yl)amino, methoxy-ethoxy, hydroxy-ethoxy, methoxy, (2-hydroxypropyl)amino, (tetrahydro-2H-pyran-4-yl)oxy, (tetrahydro-2H-pyran-4-yl)oxy, (1-ethylpiperidin-4-yl)oxy and pyrazolyl; wherein said pyrazolyl can be unsubstituted or substituted with 1 to 2 methyl groups; each
R2a is independently selected from hydrogen and OH;
R2b is selected from H, methyl, halo, fluoro-methyl, hydroxy, hydroxymethyl, difluoromethyl, formyl, methoxy and cyano;
R3 is selected from:
whereinindicates the point of attachment with L;R4 is selected from H, methyl, hydroxy-ethyl, hydroxy-propyl and 2,3-dihydroxypropyl;
R15 is selected from —CF3, methoxy, —C(CH3)2F, —CF2CH2F, —C(CH3)2CN, —C(CH3)F2, —CHF2, —C(CH3)2OH, t-butyl, 1-cyanocyclopropyl, 2-(trifluoromethyl)cyclopropyl, —C(F2)C2H5, methyl-sulfonyl, 4-ethylpiperazin-1-yl, —C(CH3)2NH2 and dimethyl-amino-methyl;
R16 is selected from H, halo, hydroxy, dimethyl-amino, hydroxy-methyl, amino-methyl, —C(CH3)2NH2 and —CF3; or a pharmaceutically acceptable salt thereof; with the proviso that a compound of formula II is not 2-(2-cyanopropan-2-yl)-N-(4-methyl-3-(1-methyl-6-oxo-5-(tetrahydro-2H-pyran-4-yl)-1,6-dihydropyridazin-3-yl)phenyl)isonicotinamide or 2-(2-fluoropropan-2-yl)-N-(4-methyl-3-(1-methyl-6-oxo-5-(tetrahydro-2H-pyran-4-yl)-1,6-dihydropyridazin-3-yl)phenyl)isonicotinamide.

US Pat. No. 10,167,278

CYCLOPROPANECARBOXAMIDE MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR

Auspex Pharmaceuticals, I...

1. A compound of Formula I:
or a salt thereof, wherein:
R1-R3 and R6-R23 are, independently, hydrogen or deuterium;
R4-R5 are, independently, —CH3, —CH2D, —CD2H, or —CD3;
at least one of R1-R23 is deuterium or contains deuterium; and
at least one of R1-R23 independently has deuterium enrichment of no less than about 10%.

US Pat. No. 10,167,277

ACTIVATORS OF CLASS I HISTONE DEACETLYASES (HDACS) AND USES THEREOF

Massachusetts Institute o...

1. A compound of Formula (B):or a pharmaceutically acceptable salt, tautomer, stereoisomer, or prodrug thereof, wherein:each of XB1, XB3, and XB4 is independently oxygen, sulfur, NRB4a, or C(RB4b)2, wherein RB4a is hydrogen, a nitrogen protecting group, or optionally substituted C1-6 alkyl, and each occurrence of RB4b is independently hydrogen, halogen, or optionally substituted C1-6 alkyl, or two RB4b groups are joined to form an optionally substituted, carbocyclic or heterocyclic ring;
XB2 is nitrogen or CRB2a, wherein RB2a is hydrogen, halogen, or optionally substituted C1-6 alkyl;
each instance of RB1 is independently halogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted carbocyclyl, optionally substituted heterocyclyl, optionally substituted aryl, optionally substituted heteroaryl, —ORB1a, —N(RB1a)2, —SRB1a, —C(?O)RB1a, —C(?O)ORB1a, —C(?O)SRB1a, —C(?O)N(RB1b)2, —OC(?O)RB1a, OC(?O)ORB1a, —OC(?O)SRB1a, —OC(?O)N(RB1b)2, —NRB1bC(?O)RB1b, —NRB1bC(?O)ORB1a, —NRB1bC(?O)SRB1a, —NRB1bC(?O)N(RB1b)2, —SC(?O)RB1a, —SC(?O)ORB1a, —SC(?O)SRB1aSC(?O)N(RB1b)2, —C(?NRB1b)RB1a, —C(?NRB1b)ORB1a, —C(?NRB1b)SRB1a, —C(?NRB1b)N(RB1b)2, —OC(?NRBb)RB1a, —OC(?NRB1b)ORB1a, —OC(?NRB1b)SRB1a, —OC(?NRB1b)N(RB1b)2, —NRB1bC(?NRB1b)RB1b, —NRB1bC(?NRB1b)ORB1a, —NRB1bC(?NRB1b)SRB1a, NRB1bC(?NRB1b)N(RB1b)2, —SC(?NRB1b)RB1a, —SC(?NRB1b)ORB1a, —SC(?NRB1b)SRB1a SC(?NRB1b)N(RB1b)2, —C(?S)RB1a, —C(?S)ORB1a, —C(?S)SRB1a, —C(?S)N(RB1b)2, —OC(?S)RB1a, OC(?S)ORB1a, —OC(?S)SRB1a, —OC(?S)N(RB1b)2, —NRB1bC(?S)RB1b, —NRB1bC(?S)ORB1a, —NRB1bC(?S)SRB1a, —NRB1bC(?S)N(RB1b)2, —SC(?S)RB1a, —SC(?S)ORB1a, —SC(?S)SRB1a, SC(?S)N(RB1b)2, —S(?O)RB1a, —SO2RB1a, —NRB1bSO2RB1a, —SO2N(RB1b)2, —CN, —SCN, or —NO2, wherein each occurrence of RB1a is independently hydrogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted carbocyclyl, optionally substituted heterocyclyl, optionally substituted aryl, or optionally substituted heteroaryl, and each occurrence of RB1b is independently hydrogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted carbocyclyl, optionally substituted heterocyclyl, optionally substituted aryl, optionally substituted heteroaryl, or a nitrogen protecting group when attached to a nitrogen atom, or two RB1b groups are joined to form an optionally substituted heterocyclic ring;
each of RB2, RB3, RB4, and RB5 is independently hydrogen, halogen, or optionally substituted C1-6 alkyl;
RB6 is hydrogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted carbocyclyl, optionally substituted heterocyclyl, optionally substituted aryl, optionally substituted heteroaryl, —N(RB6b)2, or —SRB6a, wherein RB6a is hydrogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted carbocyclyl, optionally substituted heterocyclyl, optionally substituted aryl, or optionally substituted heteroaryl, and each occurrence of RB6b is independently hydrogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted carbocyclyl, optionally substituted heterocyclyl, optionally substituted aryl, optionally substituted heteroaryl, or a nitrogen protecting group, or two RB6b groups are joined to form an optionally substituted heterocyclic ring; and
p is 0, 1, 2, 3, or 4;
provided that the compound is not of the formula:

US Pat. No. 10,167,276

COMPOUNDS AND METHODS FOR INHIBITING JAK

Dizal (Jiangsu) Pharmaceu...

5. A pharmaceutical composition comprising a compound of claim 1, and a pharmaceutically acceptable diluent, excipient or carrier.

US Pat. No. 10,167,275

AZD9291 INTERMEDIATE AND PREPARATION METHOD THEREFOR

SUZHOU MIRACPHARMA TECHNO...

1. A compound N-[2-[[2-(dimethylamino)ethyl]methylamino]-4-methoxy-5-formamidine]phenyl-2-propenamide as shown in formula II

US Pat. No. 10,167,273

SULFONYL PIPERIDINE DERIVATIVES AND THEIR USE FOR TREATING PROKINETICIN MEDIATED DISEASES

Takeda Pharmaceutical Com...

1. A compound of formula (Ia) or a pharmaceutically acceptable salt thereof,wherein
R1 is;
q is 0 or 1;
each R12 independently represents halogen, cyano, carboxyl, hydroxyl, C1-C6 alkyl, C1-C6 haloalkyl, C1-C6 alkoxy, C1-C6 hydroxyalkyl, C1-C6 alkoxycarbonyl, C1-C6 alkoxyC1-C6 alkyl or a 5- to 9-membered heterocyclic ring system;
R13 represents CHF; and
R14 represents a substituted phenyl, wherein the substituted phenyl includes at least one substituent selected from halogen, cyano, methyl, trifluoromethyl, methoxy and trifluoromethoxy.

US Pat. No. 10,167,272

MUSCARINIC AGONISTS

Heptares Therapeutics Lim...

1. A compound of the formula (1):
or a pharmaceutically acceptable salt thereof, wherein
p is 1 or 2;
q is 0, 1 or 2;
r is 1 or 2;
s is 0 or 1, where the total of r and s is 1 or 2;
wherein the moiety:

is selected from groups A to KKK as follows:

R3 is H; and
R4 is a hydrogen or a C1-6 non-aromatic hydrocarbon group which is optionally substituted with one to six fluorine atoms and wherein one or two, but not all, carbon atoms of the hydrocarbon group may optionally be replaced by a heteroatom selected from O, N and S and oxidised forms thereof.

US Pat. No. 10,167,271

FLUOROQUINOLONE CARBOXYLIC ACID COMPOUNDS AND USE THEREOF FOR THE PREPARATION OF BESIFLOXACIN HYDROCHLORIDE

MANKIND PHARMA LTD, (IN)...

1. Fluoroquinolone carboxylic acid compounds of Formula-I, and salts thereof:
wherein, R is hydrogen or a halogen.

US Pat. No. 10,167,270

SUBSTITUTED QUINAZOLINE COMPOUNDS AND USES THEREOF FOR MODULATING GLUCOCEREBROSIDASE ACTIVITY

Northwestern University, ...

1. A compound or a salt or solvate thereof having a formula:
wherein:
R1 is hydrogen or C1-C10 alkyl;
n is 0, 1, 2, 3, or 4;
R8 is hydrogen, C1-C8 alkyoxy, C1-C8 alkyl, halo, or R8 has a formula selected from
p is 1-10 and R9 is amino or R9 has a formula selected fromwherein R10 is H, C1-C6 straight chain or branched alkyl, or a succinimidyl group;R3 is pyridinyl, phenyl, thiophenyl, halo, furanyl, or pyrimidinyl, and R3 optionally is substituted at one or more positions with C1-C8 alkyl, halo, or amino, or R3 has a formula,
wherein R4 is amino, or R4 has a formulawherein R5 is CH2— or O—CH2—CH2—, and m is 0-4,R6 is H or R6 has a formula
wherein R7 is H, —OH, C1-C8 alkyl, or C1-C8 alkoxy.

US Pat. No. 10,167,269

COCKROACH ATTRACTION-AGGREGATION SUBSTANCE, COCKROACH AGGREGATION ATTRACTANT AND COCKROACH CONTROLLING AGENT

Kyoto University, Kyoto ...

1. A cockroach attraction-aggregation compound, the compound being represented by general formula:
wherein R1 to R4 are each independently selected from the group consisting of a hydrogen atom, a halogen atom,
an optionally substituted (C1-C6)alkyl group,
an optionally substituted (C3-C6)cycloalkyl group,
an optionally substituted (C2-C6)alkenyl group, and
an optionally substituted (C2-C6)alkynyl group;
wherein R5 is an unsubstituted methyl group,
wherein two of R2, R3 and R4 are hydrogen atoms and the other is selected from the group consisting of an optionally substituted (C1-C6)alkyl group, an optionally substituted (C3-C6)cycloalkyl group, an optionally substituted (C2-C6)alkenyl group, and an optionally substituted (C2-C6)alkynyl group, and
provided that in the case where R1 is methyl, R2 is a hydrogen atom, and R3 and R4 are each independently a hydrogen atom or methyl is excluded, in the case where R1 is ethyl or 2-hydroxyl-1-propyl, R2, R3 and R4 are each a hydrogen atom is excluded, in the case where R1 is ethyl, R2 and R4 are each a hydrogen atom, and R3 is methyl is excluded, in the case where R1 is ethyl, R2 and R3 are each a hydrogen atom, and R4 is methyl is excluded, and in the case where R1 is hydrogen atom, and R2, R3 and R4 are each independently a methyl is excluded, or
a salt thereof.

US Pat. No. 10,167,268

PROCESS FOR PURIFYING A CRUDE COMPOSITION OF DIALKYL ESTER OF 2,5-FURANDICARBOXYLIC ACID

Synvina C.V., Amsterdam ...

1. A process for purifying an ester composition comprising at least 90% wt of the dialkyl ester of 2,5-furandicarboxylic acid as starting dialkyl ester concentration and up to 5% wt of the monoalkyl ester of 2,5-furandicarboxylic acid as starting monoalkyl ester concentration, the percentages being based on the weight of the ester composition, which process comprises subjecting the ester composition to melt crystallization to yield a purified dialkyl ester composition containing a dialkyl concentration higher than the starting dialkyl ester concentration and a melt residue containing a monoalkyl ester concentration higher than the starting monoalkyl ester concentration,wherein the melt residue is subject to conversion into a monoalkyl ester-rich intermediate product containing a momoalkyl ester concentration of at least 10% wt, based on the weight of the intermediate product, and
wherein the monoalkyl ester-rich intermediate product that is subjected to melt crystallization has a temperature in the range of 180 to 250° C.

US Pat. No. 10,167,267

CONVERSION AND PURIFICATION OF BIOMASS

AGENCY FOR SCIENCE, TECHN...

1. A method for synthesizing an optionally substituted furoic acid, comprising:converting a biomass to an optionally substituted furan, wherein said furan is unsubstituted or substituted by at least one —C1-C10-alkyl-OH group, via a dehydration reaction in the presence of an organic solvent;
purifying the optionally substituted furan by first evaporating the organic solvent from the optionally substituted furan produced from said dehydration reaction to obtain a solid residue or an aqueous slurry, followed by adding water to the residue or aqueous slurry for extraction of the optionally substituted furan with water, collecting the supernatant separately from the residue; and
oxidizing the extracted optionally substituted furan to form the optionally substituted furoic acid.

US Pat. No. 10,167,266

SODIUM CHANNEL BLOCKERS

Parion Sciences, Inc., D...

1. A pharmaceutical composition comprising a compound of Formula (I), or a pharmaceutically acceptable salt thereof, and an osmotically active agent:wherein:X is halogen;
Y is —N(R2)2;
R1 is hydrogen or lower alkyl;
each R2 is independently —R7;
R3 is hydrogen or lower alkyl;
R4 is a group represented by formula (A):
and wherein:each RL is independently —R7, —(CH2)n—OR8, —O—(CH2)m—OR8, —(CH2)n—NR7R10, —O—(CH2)m—NR7R10, —(CH2)n(CHOR8)(CHOR8)n—CH2OR8, —O—(CH2)m(CHOR8)(CHOR8)n—CH2OR8, —(CH2CH2O)m—R8, —O—(CH2CH2O)m—R8, —(CH2CH2O)m—CH2CH2NR7R10, —O—(CH2CH2O)m—CH2CH2NR7R10, —(CH2)n—C(?O)NR7R10, —O—(CH2)m—C(?O)NR7R10, —(CH2)n—(Z)g—R7, —O—(CH2)m—(Z)g—R7, —(CH2)n—NR10—CH2(CHOR8)(CHOR8)n—CH2OR8, —O—(CH2)m—NR10—CH2(CHOR8)(CHOR8)n—CH2OR8, —(CH2)n—CO2R7, —O—(CH2)m—CO2R7, —OSO3H, —O-glucuronide, —O-glucose,

each o is independently an integer from 0 to 10;
each p is an integer from 0 to 10;with the proviso that the sum of o and p in each contiguous chain is from 1 to 10;each x is, independently, O, NR10, C(?O), CHOH, C(?N—R10), CHNR7R10, or a single bond;
each R5 is independently —(CH2)m—OR8, —O—(CH2)m—OR8, —(CH2)n—NR7R10, —O—(CH2)m—NR7R10, —(CH2)n(CHOR8)(CHOR8)n—CH2OR8, —O—(CH2)m(CHOR8)(CHOR8)n—CH2OR8, —(CH2CH2O)m—R8, —O—(CH2CH2O)m—R8, —(CH2CH2O)m—CH2CH2NR7R10, —O—(CH2CH2O)m—CH2CH2NR7R10, —(CH2)n—C(?O)NR7R10, —O—(CH2)m—C(?O)NR7R10, —(CH2)n—(Z)g—R7, —O—(CH2)m—(Z)g—R7, —(CH2)n—NR10—CH2(CHOR8)(CHOR8)n—CH2OR8, —O—(CH2)m—NR10—CH2(CHOR8)(CHOR8)n—CH2OR8, —(CH2)n—CO2R7, —O—(CH2)m—CO2R7, —OSO3H, —O-glucuronide, —O-glucose,

each R6 is independently —R7, —OR11, —N(R7)2, —(CH2)m—OR8, —O—(CH2)m—OR8, —(CH2)n—NR7R10, —O—(CH2)m—NR7R10, —(CH2)n(CHOR8)(CHOR8)n—CH2OR8, —O—(CH2)m(CHOR8)(CHOR8)n—CH2OR8, —(CH2CH2O)m—R8, —O—(CH2CH2O)m—R8, —(CH2CH2O)m—CH2CH2NR7R10, —O—(CH2CH2O)m—CH2CH2NR7R10, —(CH2)n—C(?O)NR7R10, —O—(CH2)m—C(?O)NR7R10, —(CH2)n—(Z)g—R7, —O—(CH2)m—(Z)g—R7, —(CH2)n—NR10—CH2(CHOR8)(CHOR8)n—CH2OR8, —O—(CH2)m—NR10—CH2(CHOR8)(CHOR8)n—CH2OR8, —(CH2)n—CO2R7, —O—(CH2)m—CO2R7, —OSO3H, —O-glucuronide, —O-glucose,wherein when two R6 are —OR11 and are located adjacent to each other on a phenyl ring, the alkyl moieties of the two R6 may be bonded together to form a methylenedioxy group,
each R7 is independently hydrogen or lower alkyl;
each R8 is independently hydrogen, lower alkyl, —C(?O)—R11, glucuronide, 2-tetrahydropyranyl, or

each R9 is independently —CO2R7, —CON(R7)2, —SO2CH3, or —C(?O)R7;
each R10 is independently —H, —SO2CH3, —CO2R7, —C(?O)NR7R9, —C(?O)R7, or —CH2—(CHOH)n—CH2OH;
each Z is independently CHOH, C(?O), CHNR7R10, C?NR10, or NR10;
each R11 is independently lower alkyl;
each g is independently an integer from 1 to 6;
each m is independently an integer from 1 to 7;
each n is independently an integer from 0 to 7; and
each Q is independently C—R5 or C—R6, wherein one Q is C—R5.

US Pat. No. 10,167,265

TREATMENT OF PULMONARY AND OTHER CONDITIONS

The United States of Amer...

1. A method for treating a pulmonary disease in a subject comprising administering to the subject in need thereof a therapeutically effective amount of a compound, or a pharmaceutically acceptable salt or ester thereof, having a structure of:
wherein represents a single bond;
A is CH(S—R5), wherein R5 is an acylamino-substituted carboxylalkyl, a sulfonate-substituted alkyl, or an acylamino-substituted amido; and
X1 and X2 are each independently an optionally-substituted N-heterocycle wherein the pulmonary disease is pulmonary fibrosis, chronic obstructive pulmonary disease (COPD), asthma, cystic fibrosis, acute lung injury (ALI), acute respiratory distress syndrome, pulmonary hypertension, lung cancer, or pulmonary manifestations of cystic fibrosis.

US Pat. No. 10,167,264

SUBSTITUTED PYRIMIDINES USEFUL AS EGFR-T790M KINASE INHIBITORS

Jiangsu Medolution Ltd, ...

1. A compound according to Formula I:
or a pharmaceutically acceptable salt, solvate, stereoisomer or tautomer thereof, wherein
R1 is hydrogen, C1-C6 alkoxy, F, Cl, or CF3;
R2 is C1-C6 alkyl or C(O)R3; and
R3 is C1-C6 alkyl;
with the proviso that when R1 is C1-C6 alkoxy, R2 is not C(O)R3.

US Pat. No. 10,167,263

TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS

NORTHWESTERN UNIVERSITY, ...

1. A compound of the formula:
or a pharmaceutically acceptable salt thereof, wherein:
R1 is H;
R2 is H and
R3 is —R10, —OR10, —SR10, —S(O)R10, —SO2R10, —OSO2R10, —C(O)R10, —C(O)OR10, —OC(O)R10, —OC(O)OR10, —C(O)N(R10)2, —OC(O)N(R10)2, a suitable amino protecting group, or an optionally substituted 3-8 membered saturated, partially unsaturated, or aryl monocyclic ring having 0-4 heteroatoms independently selected from nitrogen, oxygen, and sulfur, or an optionally substituted 8-10 membered saturated, partially unsaturated, or aryl bicyclic ring having 0-4 heteroatoms independently selected from nitrogen, or sulfur;
wherein R10 is hydrogen, halogen, optionally substituted C1-20 alkyl, optionally substituted phenyl, optionally substituted arylalkyl or monocyclic aryl ring having 1-3 heteroatoms independently selected from nitrogen, oxygen, and sulfur, and wherein R10 optionally is substituted with substituents selected from halogen, C1-6 alkyl, C1-6 alkoxy, C1-6 haloalkyl, nitro, hydroxy, amino, C1-6 alkylamino, cyano, isocyano, isocyanato, and isothiocyanato substituents,
providing that R3 is not benzimidazolyl and
providing that R3 is not benzothiazolyl;
m is 0-5;
each R4 is independently —R11, —SR11, —CN, —S(O)R11, —SO2R11, —OSO2R11, —N(R11)2, —NR11C(O)R11, —NR11C(O)(CO)R11, —NR11C(O)N(R11)2, —NR11C(O)OR11, —N(R11)S(O)R11, —N(R11)SO2R11, —N(R11)SO2OR11, —C(O)R11, —C(O)OR11, —OC(O)R11, —OC(O)OR11, —C(O)N(R11)2, —OC(O)N(R11)2, or a 3-8 membered saturated, partially unsaturated, or aryl monocyclic ring optionally containing 0-4 heteroatoms independently selected from nitrogen, oxygen, and sulfur,
wherein R11 is halogen, optionally substituted C1-20 alkyl, optionally substituted phenyl, optionally substituted aryl, optionally substituted arylalkyl or aryl ring having 1-3 heteroatoms independently selected from nitrogen, oxygen, and sulfur, and wherein RH optionally is substituted with substituents selected from halogen, C1-6 alkyl, C1-6 alkoxy, C1-6 haloalkyl, nitro, hydroxy, amino, C1-6 alkylamino, cyano, isocyano, isocyanato, and isothiocyanato substituents; and,
providing where R3 is H and m=1 or 2, R4 is —R12, —OR12, —SR12, CN, —S(O)R12, —SO2R12, —OSO2R12, N(R12)2, —NR12C(O)R12, —NR12C(O)(CO)R12, —NR12C(O)N(R12)2, —NR12C(O)OR12, —N(R12)S(O)R12, —N(R12)SO2R12, —N(R12)SO2OR12, —C(O)R12, —C(O)OR12, —OC(O)R12, —OC(O)OR12, —C(O)N(R12)2, —OC(O)N(R12)2, or a 3-8 membered saturated, partially unsaturated, or aryl monocyclic ring optionally containing 0-4 heteroatoms independently selected from nitrogen, oxygen, and sulfur;
wherein R12 is halogen, optionally substituted C5-20 alkyl, optionally substituted phenyl, optionally substituted aryl, optionally substituted arylalkyl or aryl ring having 1-3 heteroatoms independently selected from nitrogen, oxygen, and sulfur, and wherein R12 optionally is substituted with substituents selected from halogen, C1-6 alkyl, C1-6 alkoxy, C1-6 haloalkyl, nitro, hydroxy, amino, C1-6 alkylamino, cyano, isocyano, isocyanato, and isothiocyanato substituents,
providing where R3 is H, m=2 and at least one R4 is halogen, the at least one R4 that is halogen is mew or ortho to the C—O bond; and
providing where R3 is H, m=1, and R4 is bromine, R4 is meta to the C—O bond.

US Pat. No. 10,167,261

2-OXO-3,4-DIHYDROQUINOLIN-6-YL SULPHONAMIDE CPDS AND THEIR USE AS PLANT GROWTH REGULATORS

THE REGENTS OF THE UNIVER...

1. A compound of Formula (I):
wherein:
R1 is selected from hydrogen, alkyl, cyano-alkyl, haloalkyl, alkoxy-alkyl, haloalkoxy-alkyl, cycloalkyl-alkyl, alkenyl, haloalkenyl, alkynyl, haloalkynyl, and heterocycloalkyl; or
R1 is selected from alkyl-aryl, cycloalkyl, phenyl and heteroaryl, each optionally substituted with one to three Rx;
each Rx is independently selected from halogen, cyano, alkyl, haloalkyl, alkoxy, haloalkoxy, alkylsulfanyl, haloalkylsulfanyl, alkylsulfinyl, haloalkylsulfinyl, alkylsulfonyl, haloalkylsulfonyl and cycloalkyl;
R2a, R2b, R3a, R3b, R4, R5 and R6 are independently selected from hydrogen, halogen, cyano, alkyl, alkenyl, alkynyl, alkoxy, haloalkyl, haloalkoxy and cycloalkyl;
R2a and R2b, or R2a and R3a, together with the atom to which they are attached, are optionally joined to form a cycloalkyl;
L is selected from alkyl, alkenyl, alkoxy and alkoxy-alkyl, each optionally substituted with one to three moieties independently selected from halogen, cyano, alkyl and alkoxy;
A is cycloalkyl optionally substituted with one to four Ry;
each Ry is independently selected from halogen, cyano, nitro, alkyl, haloalkyl, —OH, alkoxy, haloalkoxy, alkylsulfanyl, haloalkylsulfanyl, alkylsulfinyl, haloalkylsulfinyl, alkylsulfonyl, haloalkylsulfonyl, cycloalkyl, ?O, ?N—OH, —N?OMe, COOH, COOR9, CONHR9, CONR9aR9 and NHCOR9,
with the proviso that when one or more Ry is ?O, ?N—OH or —N?OMe, A is not C3 cycloalkyl;
R9 and R9a are independently alkyl;
each R8 is independently selected from hydrogen, halogen, cyano, alkyl, haloalkyl, alkoxy, haloalkoxy, alkylsulfanyl, haloalkylsulfanyl, alkylsulfinyl, haloalkylsulfinyl, alkylsulfonyl, haloalkylsulfonyl, alkenyl, haloalkenyl, alkynyl, haloalkynyl, cycloalkyl and alkoxy-alkyl;
n is selected from 1, 2, and 3;
or salts or N-oxides thereof.

US Pat. No. 10,167,260

2-AMINOPYRIDINE-BASED SELECTIVE NEURONAL NITRIC OXIDE SYNTHASE INHIBITORS

Northwestern University, ...

1. A compound selected from compounds of a formulawherein X is selected from N and CH; L is selected from (OCH2)n and CH2NH(CH2)n moieties, and n is an integer selected from 1-3; and R1 is selected from amino, pyridin-2-yl, pyridin-4-yl, piperidin-4-yl, phenyl, fluorophenyl and chlorophenyl moieties, and salts thereof.

US Pat. No. 10,167,259

ALLOSTERIC INHIBITORS OF PROTEASOME AND METHODS OF USE THEREOF

The Board of Regents of t...

1. A compound of the formula:wherein:A1 is

wherein:
A2 is —O—;
A3 is alkanediyl(C?6), alkenediyl(C?6), or a substituted version of either of these groups;
R2 is

wherein:
Y1, Y5, Y6, Y7, Y8, and Y9 are each independently hydrogen, hydroxy, phosphate, halo, alkyl(C?12), alkoxy(C?12), acyloxy(C?12), heteroaryl(C?12), acyl(C?12), alkylamino(C?12), dialkylamino(C?12), or a substituted version of any of these groups, and Y2 and Y4 are alkoxy(C?12) or substituted alkoxy(C?12), and Y3 is alkoxy(C<12);
R3 is hydrogen, alkyl(C?8), or a substituted alkyl(C?8); and
R1 is

wherein:
X6 is hydrogen or hydroxy;
X7 is O, NH, or C(R5)2;
X8 is hydrogen, hydroxy, phosphate, halo, alkyl(C?6), alkoxy(C?6), acyloxy(C?6), heteroaryl(C?12), acyl(C?6), alkylamino(C?6), dialkylamino(C?6), or a substituted version of any of these groups;
X9, X10, X11, and R5 are each independently hydrogen, hydroxy, phosphate, halo, alkyl(C?12), alkoxy(C?12), acyloxy(C?12), heteroaryl(C?12), acyl(C?12), alkylamino(C?12), dialkylamino(C?12), or a substituted version of any of these groups.

US Pat. No. 10,167,258

INHIBITORS OF MITOCHONDRIAL PYRUVATE DEHYDROGENASE KINASE ISOFORMS 1-4 AND USES THEREOF

The Board of Regents of t...

1. A compound of the formula:
wherein:
X1 is hydrogen, halogen, hydroxy, amino, cyano, nitro, or oxo, or alkyl(C?12), alkenyl(C?12), alkynyl(C?12), aryl(C?18), aralkyl(C?18), heterocycloalkyl(C?12), heteroaryl(C?12), acyl(C?12), —C(O)-alkoxy(C?12), alkoxy(C?12), alkenyloxy(C?12), alkynyloxy(C?12), aryloxy(C?18), aralkyloxy(C?18), heterocycloalkyloxy(C?12), heteroaryloxy(C?12), acyloxy(C?12), alkylamino(C?12), dialkylamino(C?12), alkenylamino(C?12), alkynylamino(C?12), arylamino(C?18), aralkylamino(C?18), heterocycloalkylamino(C?12), heteroarylamino(C?12), amido(C?12), -arenediyl(C?6)-heteroaryl(C?12), or a substituted version of any of these groups, or is taken together with X6 as defined below;
X2 and X5 are each independently hydrogen, hydroxy, nitro, cyano, or amino, or
alkyl(C?12), alkenyl(C?12), alkynyl(C?12), aryl(C?18), aralkyl(C?18), heterocycloalkyl(C?12), heteroaryl(C?12), acyl(C?12), alkoxy(C?12), alkenyloxy(C?12), alkynyloxy(C?12), aryloxy(C?18), aralkyloxy(C?18), heterocycloalkyloxy(C?12), heteroaryloxy(C?12), acyloxy(C?12), alkylthio(C?12), alkenylthio(C?12), alkynylthio(C?12), arylthio(C?18), aralkylthio(C?18), heterocycloalkylthio(C?12), heteroarylthio(C?12), acylthio(C?12), alkylamino(C?12), dialkylamino(C?12), alkenylamino(C?12), alkynylamino(C?12), arylamino(C?18), aralkylamino(C?18), heterocycloalkylamino(C?12), heteroarylamino(C?12), amido(C?12), -alkanediyl(C?6)-heterocycloalkyl(C?12), or a substituted version of any of these groups; or

wherein:
R is hydrogen; or
alkyl(C?12), alkenyl(C?12), acyl(C?12), aryl(C?12), aralkyl(C?12), or a substituted version of any of these groups;
X3 and X4 are each independently hydrogen, hydroxy, or amino, or
alkoxy(C?12), alkenyloxy(C?12), alkynyloxy(C?12), aryloxy(C?18), aralkyloxy(C?18), heterocycloalkyloxy(C?12), heteroaryloxy(C?12), acyloxy(C?12), alkylamino(C?12), dialkylamino(C?12), alkenylamino(C?12), alkynylamino(C?12), arylamino(C?18), aralkylamino(C?18), heterocycloalkylamino(C?12), heteroarylamino(C?12), amido(C?12), -alkanediyl(C?6)-heterocycloalkyl(C?12), or a substituted version of any of these groups; or

wherein:
R is hydrogen; or
alkyl(C?12), alkenyl(C?12), acyl(C?12), aryl(C?12), aralkyl(C?12), or a substituted version of any of these groups;
X6 is hydrogen, halogen, hydroxy, amino, nitro, or cyano, or
alkyl(C?12), alkenyl(C?12), alkynyl(C?12), aryl(C?18), aralkyl(C?18), heterocycloalkyl(C?12), heteroaryl(C?12), acyl(C?12), alkoxy(C?12), alkenyloxy(C?12), alkynyloxy(C?12), aryloxy(C?18), aralkyloxy(C?18), heterocycloalkyloxy(C?12), heteroaryloxy(C?12), acyloxy(C?12), alkylamino(C?12), dialkylamino(C?12), alkenylamino(C?12), alkynylamino(C?12), arylamino(C?18), aralkylamino(C?18), heterocycloalkylamino(C?12), heteroarylamino(C?12), or amido(C?12), or a substituted version of any of these groups, or is taken together with X1 as defined below;
Y1, Y2, Y3, Y4, and Y5 are each independently hydrogen, amino, cyano, halo, hydroxy, or nitro, or
alkyl(C?12), alkenyl(C?12), alkynyl(C?12), aryl(C?12), aralkyl(C?12), heteroaryl(C?12), heterocycloalkyl(C?12), acyl(C?12), or a substituted version of any of these groups;
X1 and X6 when taken together have the formula:

wherein:
X1? and X6? are each independently hydrogen, hydroxy, halo, or amino;
alkyl(C?12), alkenyl(C?12), alkynyl(C?12), aryl(C?12), aralkyl(C?12), heteroaryl(C?12), acyl(C?12), or a substituted version of any of these groups;
provided that at least one of Y1, Y2, Y3, Y4, or Y5 are hydroxy or alkoxy(C?12) and that X2, X3, X4, and X5 are not all hydrogen, or that when X1 is oxo then X6 is not aryl(C?8);
or a pharmaceutically acceptable salt thereof.

US Pat. No. 10,167,257

INDOLE DERIVATIVES FOR USE IN MEDICINE

Iomet Pharma Ltd., Midlo...

1. A compound of the following formula, or a pharmaceutically acceptable salt thereof:wherein:each of R1, R2, R3 and R4 is independently selected from H, halogen, —CN, C1-C6 alkyl, C1-C6 halogenated alkyl, —OH, C1-C7 alkoxy, —O—CF3, —C(O)—NH2, —C(O)—NHMe, NH—SO2Me, NH—SO2Et, —NH—SO2Pr, and —NH—SO2iPr;
R5 is H;
R7 is selected from H and C1-C6 alkyl;
R61 is selected from H and C1-C6 alkyl;
R65 is a heterocyclic group selected from pyrazol-1-yl, pyrazol-3-yl, pyrazol-4-yl, pyrazol-5-yl, 1,2,3-triazol-4-yl, 1,2,3-triazol-5-yl, 1,2,4-triazol-1-yl, 1,2,4-triazol-3-yl, 1,2,4-triazol-5-yl, pyridin-2-yl, pyridin-3-yl, pyridin-4-yl, pyrimidin-2-yl, pyrimidin-4-yl, pyrimidin-5-yl, pyrimidin-6-yl, piperidin-1-yl, piperidin-2-yl, piperidin-3-yl, piperidin-4-yl, oxazol-2-yl, oxazol-4-yl, oxazol-5-yl, isoxazol-3-yl, isoxazol-4-yl, isoxazol-5-yl, tetrazol-1-yl, tetrazol-2-yl, and tetrazol-5-yl; each of which is optionally substituted with one to three substituents independently selected from halogen, methyl, ethyl, propyl, —C(O)-methyl, —S(O)2-methyl and phenyl; and
R63 and R64 together form a 3-6 membered carbocyclic or heterocyclic ring selected from cyclopropyl, cyclobutyl, cyclopentyl, cyclopentenyl, cyclohexyl, cyclohexenyl, aziridinyl, azetidinyl, pyrrolidinyl, piperidinyl, piperazinyl, oxetanyl, tetrahydrofuranyl and tetrahydropyranyl.

US Pat. No. 10,167,256

PSYCHOTROPHIC AGENTS AND USES THEREOF

LB PHARMACEUTICALS INC., ...

1. A compound of Formula I:
including pharmaceutically acceptable salts and stereoisomers thereof, wherein:
R1 is

 and
X and Z are the same or different and independently selected from the group consisting of hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroarylalkyl, and heteroaryl, optionally the alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, heterocyclyl, heterocyclylalkyl, aryl, arylalkyl, heteroarylalkyl, and heteroaryl groups are further substituted with one or more substitution groups selected from the group consisting of halogens, chlorine, bromine, fluorine, amines, hydroxy groups, carboxylic acids, nitro groups, carbonyl and other alkyl and aryl groups as defined herein; with the proviso that at least one of X and Z is not hydrogen.

US Pat. No. 10,167,255

PROCESS FOR PREPARING AMINES

STUDIENGESELLSCHAFT KOHLE...

1. A process for preparing an amine of formula I comprising reductive amination of a carbonyl compound of the formula II with an amine compound of the formula III and carbon monoxide as reductant in the presence of a catalyst and without introducing hydrogen (H2) from an external hydrogen source to yield said amine of formula I:
wherein:
R1 and R2 are each independently hydrogen or a substituent selected from the group consisting of C1-C20 alkyl, C2-C20 alkenyl, C2-C20 alkynyl, aryl, C1-C20 carboxylate, C1-C20 alkoxy, C2-C20 alkenyloxy, C2-C20 alkynyloxy, aryloxy, C2-C20 alkoxycarbonyl, C1-C20 alkylthiol, arylthiol, C1-C20 alkylsulfonyl, and C1-C20 alkylsulfinyl, each of which is optionally substituted with one or more moieties selected from the group consisting of C1-C10 alkyl, C1-C10 alkoxy, aryl, and one or more functional groups selected from the group consisting of hydroxyl, thiol, thioether, ketone, aldehyde, ester, ether, amine, imine, amide, nitro, carboxylic acid, disulfide, carbonate, isocyanate, carbodiimide, carboalkoxy, carbamate, and halogen, wherein at least one of R1 and R2 is not hydrogen; and
R3 and R4 are each independently hydrogen or a substituent selected from the group consisting of C1-C20 alkyl, C2-C20 alkenyl, C2-C20 alkynyl, aryl, C1-C20 carboxylate, C1-C20 alkoxy, C2-C20 alkenyloxy, C2-C20 alkynyloxy, aryloxy, C2-C20 alkoxycarbonyl, C1-C20 alkylthiol, arylthiol, C1-C20 alkylsulfonyl, and C1-C20 alkylsulfinyl, each of which is optionally substituted with one or more moieties selected from the group consisting of C1-C10 alkyl, C1-C10 alkoxy, aryl, and one or more functional groups selected from the group consisting of hydroxyl, thiol, thioether, ketone, aldehyde, ester, ether, amine, imine, amide, nitro, carboxylic acid, disulfide, carbonate, isocyanate, carbodiimide, carboalkoxy, carbamate, and halogen, wherein at least one of R3 and R4 is not hydrogen.

US Pat. No. 10,167,254

IDO INHIBITORS

Bristol-Myers Squibb Comp...

1. A method for treating a cancer that is melanoma, lung cancer, head cancer, neck cancer, renal cell carcinoma, or bladder cancer in a human in need of such treatment comprising administering to said human a therapeutically effective amount of a compound according to formula (I)
wherein:
Y is N, CH or CF;
V is N, CH or CF;
R1 is —COOH, —COOC1-C6 alkyl, —CONH2, —CN, optionally substituted 5 or 6 membered heterocyclyl having 1-4 ring vertices independently selected from O, N, S, 5 or 6 membered optionally substituted heteroaryl having 1-4 ring vertices independently selected from O, N, S, —NHCONHR13, —CONHSO2R14, —CONHCOR13, —SO2NHCOR13, —CONR13, —CONHSO2NR13R14, —SO2NHR13, —NHCONHSO2R13, —CHCF3OH, —COCF3, —CR2R3OH, or —NHSO2R13;
R13 is H, optionally substituted C1-C10 alkyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C2-C10 alkenyl, optionally substituted C2-C10 alkynyl, optionally substituted 5-6 membered heterocyclyl having 1-4 ring vertices independently selected from O, N, S, optionally substituted phenyl, or optionally substituted 5-6 membered heteroaryl having 1-4 ring vertices independently selected from O, N, S;
R14 is H, optionally substituted C1-C10 alkyl, phenyl, or C3-8 cycloalkyl;
R2 and R3 are independently -hydrogen, optionally substituted C1-C10 alkyl, optionally substituted C3-8 cycloalkyl, or optionally substituted phenyl; or
R2 and R3 are taken together with the carbon to which they are attached to form an optionally substituted 3- to 6-membered carbocyclic or heterocyclic ring;
R4 and R5 are independently H, optionally substituted C1-C10 alkyl, optionally substituted C1-C10-alkoxy-C1-C10-alkyl, optionally substituted C1-C10 alkoxy, optionally substituted aryl, optionally substituted aryl-C1-C10-alkyl, optionally substituted 5- to 8-membered heteroaryl containing 0-3 heteroatoms selected form N, S and O, optionally substituted C3-C8 cycloalkyl or optionally substituted heterocyclyl containing 0-3 heteroatoms selected form N, S and O; or
R4 and R5 are taken together with the nitrogen to which they are attached to form a 4- to 8-membered optionally substituted heterocyclic ring containing 0-3 additional heteroatoms selected from —N—, —S— and —O—; or
R4 and R5 are taken together with the nitrogen to which they are attached to form a 6- to 10-membered optionally substituted heterobicyclic ring containing 0-3 additional heteroatoms selected from —N—, —S—, and —O—;
R6 is optionally substituted 5 or 6 membered aryl, optionally substituted 5 or 6 membered heteroaryl having 1 to 4 ring vertices independently selected from O, N, S, optionally substituted C3-C8 cycloalkyl optionally substituted 9 to 10 membered fused bicyclic heterocyclyl having 1 to 4 ring vertices independently selected from O, N, S, 9 to 10 membered fused bicyclic heteroaryl having 1 to 4 ring vertices independently selected from O, N, S or —COR7;
R7 is optionally substituted —CR2R3-5 or 6 membered aryl, optionally substituted —CR2R3-5 or 6 membered heteroaryl, —CR2R3-3 to 6 membered heterocyclyl, optionally substituted 5 or 6 membered aryl, optionally substituted 5 or 6 membered heteroaryl, optionally substituted C3-C8 cycloalkyl, or optionally substituted 3 to 6 membered heterocyclyl; and
Rx and Ry are each independently H, optionally substituted C1-C10 alkyl, optionally substituted C1-C10 alkoxy, or optionally substituted C3-C8 cycloalkyl; or
Rx and Ry are taken together with the carbon to which they are attached to form a 3- to 7-membered heterocyclic ring containing 0-3 additional heteroatoms selected from —N—, —S— and —O—;
and/or a stereoisomer, a tautomer or a pharmaceutically acceptable salt thereof.

US Pat. No. 10,167,253

IONIZABLE COMPOUNDS AND COMPOSITIONS AND USES THEREOF

Nitto Denko Corporation, ...

1. A compound comprising the structure shown in Formula I
wherein R1 and R2 are
R1=CH2(CH2)nOC(?O)R4
R2=CH2(CH2)mOC(?O)R5
wherein n and m are each independently from 1 to 2; and R4 and R5 are independently for each occurrence a C(12-20) alkyl group, or a C(12-20) alkenyl group;
wherein R3 is selected from

wherein
each R6 is independently selected from H, alkyl, hydroxyl, hydroxyalkyl, alkoxy, alkoxyalkoxy, and aminoalkyl;
each R7 is independently selected from H, alkyl, hydroxyalkyl, and aminoalkyl;
Q is O or NR7.

US Pat. No. 10,167,252

COMPOUNDS AND MIXTURES WITH ANTIDEGRADANT AND ANTIFATIGUE EFFICACY AND COMPOSITIONS INCLUDING SUCH COMPOUNDS

Eastman Chemical Company,...

1. An antidegradant compound represented by formula I:
wherein each X is independently selected from the group consisting of ethyl, methyl, or hydrogen.

US Pat. No. 10,167,250

PROCESS FOR THE PREPARATION OF 2-(TRIHALOMETHYL) BENZAMIDE

SRF Limited, Gurgaon (IN...

1. A process for the preparation of 2-(trihalomethyl) benzamide of Formula I,
wherein X is selected from the group consisting of fluorine, chlorine, bromine and iodine; and R is hydrogen or substituted/unsubstituted C1-C7 alkyl group, said process comprising:
a) reacting a reaction mixture consisting of a compound of Formula II with a compound of Formula III in iso-propanol to obtain the compound of Formula I; and

wherein X is selected from the group consisting of fluorine, chlorine, bromine and iodine; and R is hydrogen or substituted/unsubstituted C1-C7 alkyl group,
b) isolating the compound of Formula I formed in (a).

US Pat. No. 10,167,249

AMINO AND IMINO PROPIONIC ACIDS, PROCESS OF PREPARATION AND USE

INSTITUTO MEXICANO DEL PE...

1. A corrosion inhibiting composition including a corrosion inhibiting compound consisting of N-alkenyl amine or imino propionic acid of structural formula:where R is a linear or branched alkenyl chain having 1 to 30 carbon atoms, R1 is a radical represented by —H or —CH3 and R2 is —H.

US Pat. No. 10,167,246

PREPARATIVE METHOD FOR CARBOXYLIC ACIDS

ZHEJIANG ZHUJI UNITED CHE...

1. A preparative method for carboxylic acids, wherein compounds (II) are reacted in the presence of hydrogen peroxide and base to produce target products (I), the reaction scheme is shown as below:
wherein R1 is an aryl, a pyridyl, a pyrimidyl, a pyridazinyl, a pyrazinyl, a benzothienyl, a benzofuranyl, a quinolinyl, an isoquinolinyl, a thiadiazolyl, a C1-6 alkyl, a C3-6 cycloalkyl, a C2-6 alkenyl, or C2-6 alkynyl; R2 is an alkoxycarbonyl, an alkylaminocarbonyl, an aminocarbonyl, an alkylthiolcarbonyl, a cyano, a sulfonyl, a sulfinyl, an aldehyde, or a nitro, R3 is an alkoxycarbonyl, an alkyl amido carbonyl, an aminocarbonyl, a cyano, a sulfonyl, a sulfinyl, or a nitro.

US Pat. No. 10,167,245

METHOD FOR HYDROFORMYLATING CYCLOOCTADIENE USING 4-([1,1?:3?,1?-TERPHENYL]-2?-YLOXY)-S-DINAPHTHO[2,1-D:1?,2?-F][1,3,2]DIOXAPHOSPHEPINE

EVONIK DEGUSSA GMBH, Ess...

1. A method for hydroformylating cyclooctadiene, comprising the method steps of:a) initially charging cyclooctadiene;
b) adding a complex comprising:
a metal atom selected from: Rh, Ru, Co, Ir, and
a ligand having the structure (1):

or
adding a precursor complex comprising a metal atom selected from: Rh, Ru, Co, lr, and a compound having the structure (1):

c) feeding in H2 and CO,
d) heating the reaction mixture, wherein the cyclooctadiene is converted to an aldehyde.

US Pat. No. 10,167,244

METHOD FOR HYDROFORMYLATING CYCLOOCTADIENE USING 2-(ANTHRACEN-9-YLOXY)-4,4,5,5-TETRAMETHYL-1,3,2-DIOXAPHOSPHOLANE

EVONIK DEGUSSA GMBH, Ess...

1. A method for hydroformylating cyclooctadiene, comprising the method steps of:a) initially charging cyclooctadiene;
b) adding a complex comprising:
a metal atom selected from: Rh, Ru, Co, Ir, and
a ligand having the structure (1):

or
adding a precursor complex comprising a metal atom selected from: Rh, Ru, Co, Ir, and a compound having the structure (1):

c) feeding in H2 and CO,
d) heating the reaction mixture, wherein the cyclooctadiene is converted to an aldehyde.

US Pat. No. 10,167,243

BIOMASS CONVERSION PROCESS TO HYDROCARBONS

SHELL OIL COMPANY, Houst...

1. A process for the production of a higher hydrocarbon from solid biomass, said process comprising:a. providing a biomass solid containing cellulose, hemicellulose, and lignin;
b. digesting and hydrodeoxygenating the biomass solid in a liquid digestive solvent in the presence of a hydrothermal hydrocatalytic catalyst and hydrogen at a temperature in a range of 110° C. to less than 300° C. and at a pressure in a range of from 20 bar to 200 bar, said liquid digestive solvent containing a solvent mixture having a boiling point of at least 40° C., to form a stable oxygenated hydrocarbon intermediate product having a viscosity of less than 100 centipoise (at 50° C.), a diol content of at least 2 wt. %, less than 2 wt. % of sugar, and less than 2 wt. % acid (based on acetic acid equivalent), based on the stable oxygenated hydrocarbon intermediate product, and at least 60% of carbon in the stable oxygenated hydrocarbon intermediate product exists in molecules having 9 carbon atoms or less;
c. separating the stable oxygenated hydrocarbon intermediate product to an organic rich phase and an aqueous rich phase;
d. reacting at least a portion of the aqueous rich phase with an acidic amorphous silica alumina catalyst at a temperature in a range from 300° C. to 400° C. to convert diol in the aqueous rich phase into monooxygenate compounds thereby producing monooxygenate-containing stream comprising water, organic monooxygenates, and unsaturated aliphatic hydrocarbons;
e. contacting at least a portion of the monooxygenate-containing stream with a solid acid condensation catalyst at a temperature in a range from 275° C. to about 425° C. thereby producing a first higher hydrocarbons stream; and
f. contacting at least a portion of the organic rich phase with a solid acid condensation catalyst at a temperature in a range from 275° C. to about 425° C. thereby producing a second higher hydrocarbons stream.

US Pat. No. 10,167,242

PROCESS FOR PREPARING A C3-C7 (HYDRO) FLUOROALKENE BY DEHYDROHALOGENATION

Mexichem Amanco Holding S...

1. A process for preparing a C3-7 (hydro)fluoroalkene comprising dehydrohalogenating a C3-7 hydro(halo)fluoroalkane in the presence of a catalyst consisting of a metal oxide supported on alumina, wherein the catalyst has a sodium content of less than about 800 ppm, wherein the metal of the metal oxide is a transition metal selected from the group consisting of Cr, Nb, Ta, V, Mo, or Co and optionally wherein the catalyst further contains at least one additional metal selected from the group consisting of Zn, Cr, In, Co and mixtures thereof.

US Pat. No. 10,167,241

TWO-BED PARAFFIN TO OLEFIN ENHANCEMENT PROCESS

UOP LLC, Des Plaines, IL...

1. A process for the removal of heavy aromatics from an olefins stream comprising:passing an olefins feed stream to a first adsorbent unit in two unit adsorbent system to generate a first adsorbent effluent stream with reduced heavy aromatics content;
running the first adsorbent unit until breakthrough;
equalizing pressure in a second adsorbent unit to the pressure of the first adsorbent unit;
passing the olefins feed stream to the second adsorbent unit to generate a second adsorbent unit effluent stream with reduced heavy aromatics content;
passing the second adsorbent unit effluent stream to the first adsorbent unit, displacing the fluid in the first adsorbent unit;
discontinuing the first adsorbent unit displacement and moving the first adsorbent unit off-line and the second adsorbent unit on-line;
performing a trim displacement of the first adsorption unit following the first adsorption unit displacement;
passing regenerant to the first adsorbent unit to regenerate the first adsorbent unit, wherein the regenerant flows in a co-current direction relative to the olefin feed stream through the first adsorbent unit;
equalizing the in the first adsorbent unit to the pressure of the second adsorbent unit;
passing the olefins feed stream to the first adsorbent unit to generate the first adsorbent unit effluent stream;
passing the first adsorbent unit effluent stream to the second adsorbent unit, displacing the fluid in the second adsorbent unit;
discontinuing the second adsorbent unit displacement and moving the second adsorbent unit off-line and the first adsorbent unit on-line;
performing a trim displacement of the second adsorption unit following the second adsorption unit displacement; and
passing regenerant to the second adsorbent unit to regenerate the second adsorbent unit, wherein the regenerant flows in a co-current direction relative to the olefin feed stream through the first adsorbent unit.

US Pat. No. 10,167,240

METHOD AND APPARATUS FOR SOLUBILIZING HUMIC ACID GRANULES

Humic Growth Solutions, I...

1. A method of reconstituting humic acid in solid form as an aqueous solution, comprising the steps of:forming a mixture comprising water and naturally occurring, solid humic acid in a fixed-dimension tank having inlet structure and an outlet, a fixed volume of at least about 300 gallons, and a lower section with said outlet being adjacent the bottom of the lower section,
said mixture-forming step comprising the steps of introducing solid, naturally occurring humic acid in the form of granules and/or powders through said inlet structure and into the confines of said tank, and also introducing water through the inlet structure into the confines of said tank;
forming said aqueous solution by continuously recirculating said mixture from said outlet and to said inlet structure using a recirculation assembly, and agitating said mixture using a motor-driven mixing shaft extending into the confines of the tank, said recirculation assembly including a pump equipped with an impeller and capable of recirculating said mixture at a rate of at least about 125 gallons per minute from said outlet to said inlet structure, and
allowing said mixture to reside within said tank for a residence time of at least about 2 minutes during said recirculation step; and
recovering a solution of humic acid which resists undue sedimentation for at least about 3 days.

US Pat. No. 10,167,237

PROCESS AND A PLANT FOR OXIDATIVE BIOSTABILIZATION OF CITRUS PULP

12. A system for oxidative biostabilization of citrus pulp, said system comprising:a mixer having a configuration capable of mixing a mass of fresh pulp with a mass of active biostabilized pulp to obtain a reaction mixture;
a first open-chamber reactor having a configuration capable of oxidative biostabilization in air of the reaction mixture, said first reactor being provided with a first inlet end in communication with said mixer and a second end for outlet of active biostabilized pulp;
a mechanical blade turner associated within said reactor, said turner having a configuration capable of feeding the reaction mixture along said reactor between said first end and said second end;
a blower having a configuration capable of blowing air into said first reactor from beneath; and
a mechanical movement device having a configuration capable of transferring a partial mass of the active biostabilized pulp from an intermediate area of said first reactor or an area downstream of said second end, to an area upstream of said mixer.

US Pat. No. 10,167,235

JOINED BODY AND METHOD FOR PRODUCING THE SAME

NGK Insulators, Ltd., Na...

1. A joined body, comprising:a porous ceramic;
a metal member; and
a joint of an oxide ceramic that penetrates into pores of the porous ceramic and joins the porous ceramic to the metal member,
wherein a penetration depth of the oxide ceramic into the ores of the porous ceramic is 10 ?m or more.

US Pat. No. 10,167,234

METHOD OF MAKING AN ALUMINA-SILICATE OXYNITRIDE AND CUBIC BORON NITRIDE CERAMIC COMPOSITE

King Fahd University of P...

1. A method for producing a composite of cubic boron nitride (cBN) dispersed in a SiAlON ceramic, the method comprising:mixing
silicon nitride nanoparticles,
aluminum nitride nanoparticles,
silica nanoparticles,
calcium oxide nanoparticles, and
cubic boron nitride (cBN) microparticles to produce a mixture, and
sintering the mixture to produce the composite.

US Pat. No. 10,167,226

ANTI-STATIC AGENT FOR GLASS FIBER INSULATION

Johns Manville, Denver, ...

1. A composition comprising:ground glass fiber trimmings, wherein the ground glass fiber trimmings are formed from trimming edges of a batt or roll formed from glass fibers;
a polyether antistatic agent, wherein the polyether antistatic agent has a molecular weight of less than about 2000; and
a dedusting agent, wherein the dedusting agent comprises less than 0.3% by weight of the composition.

US Pat. No. 10,167,225

SUBSTRATE PROVIDED WITH A STACK HAVING THERMAL PROPERTIES AND A SUBSTOICHIOMETRIC INTERMEDIATE LAYER

SAINT-GOBAIN GLASS FRANCE...

1. A substrate coated on one face with a thin-films stack having reflection properties in the infrared and/or in solar radiation comprising a single metallic functional layer and two antireflection coatings, said coatings each comprising at least one dielectric layer, said functional layer being positioned between the two antireflection coatings wherein at least one of said antireflection coatings comprises an intermediate layer, which is an absorbent layer comprising zinc tin oxide SnxZnyOz with a ratio of 0.1?x/y?2.4 with 0.75(2x+y)?z?0.95(2x+y), and having a physical thickness of between 2 nm and 25 nm.

US Pat. No. 10,167,221

PREFINING APPARATUS FOR CONDITIONING GLASSES

Corning Incorporated, Co...

1. A glass prefiner comprising:a molten glass holding chamber having a top portion, a bottom portion, and an enclosing sidewall;
a foam breaker having a head and a stein, the head configured to engage glass foam within the chamber; and
an exit conduit having a first opening, a second opening, and an intermediate passage, the first opening positioned in a lower section of the chamber to be immersed in molten glass below the glass foam and the second opening positioned in an upper section of the chamber to be above the glass foam, the exit conduit defining a space above the second opening between the exit conduit and the top portion of the chamber;
wherein the top portion of the chamber includes a third opening configured to accommodate the stem of the foam breaker, the stem of the foam breaker inserted in the third opening to provide foam-breaking movement to the head of the foam breaker within the chamber;
wherein the sidewall includes an inlet configured to receive molten glass from a molten glass source and an outlet configured to discharge prefined molten glass; and
wherein the exit conduit is in fluid communication with the outlet such that only prefined molten glass passing through the exit conduit at the first opening may be discharged through the outlet.

US Pat. No. 10,167,220

METHOD AND APPARATUS FOR ADDING THERMAL ENERGY TO A GLASS MELT

Corning Incorporated, Co...

1. A method for fining molten glass comprising:introducing a gas into an apparatus for generating a thermal plasma by a radio frequency (RF) electromagnetic field, the apparatus comprising:
an electrode,
a grounded electrode,
a dielectric plasma confinement vessel extending between the electrode and the grounded electrode,
a magnetic field generator extending around the dielectric plasma confinement vessel,
an inlet for delivering a gas into the dielectric plasma confinement vessel,
an RF current source to create the RF electromagnetic field for converting the gas into a thermal plasma, and
an outlet for delivering the thermal plasma,
introducing molten glass into a fining vessel; and
contacting the molten glass with the thermal plasma.

US Pat. No. 10,167,219

ECOLOGICAL BIOWATER PURIFICATION SYSTEM

1. An ecological biowater purification system comprising at least one water purification tank that comprises:a water inlet that admits a water flow into each water purification tank of the at least one water purification tank;
a water outlet that discharges the water flow from each water purification tank of the at least one water purification tank;
a water purification device comprising a plurality of water purification pools that communicate with one another and that include:
a sedimentation pool that communicates with the water inlet;
an anaerobic pool that communicates with the sedimentation pool;
an anoxic pool that communicates with the anaerobic pool;
a level-1 biological filter pool that communicates with the anoxic pool; and
a level-2 biological filter pool that communicates with the level-1 biological filter and that communicates with the water outlet, each pair of adjacent water purification pools of the plurality of water purification pools having a baffle board and communication hole combination to facilitate communication with one another, each water purification pool of the water purification pools being provided with a carrier that contains a stuffing material for water purification and that is configured to be replaceable;
a suction device that comprises a plurality of suction nozzles, each suction nozzle of the plurality of suction nozzles being disposed on a respective bottom of each water purification pool; and a plurality of suction pipes, each suction pipe of the plurality of suction pipes being connected to one suction nozzle of the plurality of suction nozzles so as to discharge precipitates out of a respective water purification pool of the at least one water purification pools;
a first backflow device including a water pump connected between the level-2 biological filter pool and the sedimentation pool to cause a portion of water contained in the level-2 biological filter pool to flow back to the sedimentation pool; and
a second backflow device including a water pump connected between (1) the level-1 biological filter pool and the level-2 biological filter pool and (2) the anaerobic pool to cause a portion of water contained in the level-1 biological filter pool and in the level-2 biological filter pool to flow back to the anaerobic pool,
wherein, when the at least one water purification tank comprises more than one water purification tank, the outlet of one water purification tank is connected to the inlet of another water purification tank.

US Pat. No. 10,167,217

PROCESS FOR INDUSTRIAL PRODUCTION OF SEA WATER BASICALLY SUITABLE FOR FOOD USE

STERALMAR SRL, Bisceglie...

1. A process for industrial production of sea water suitable for alimentary use, comprising the following steps:A) drawing sea water and decanting the sea water to obtain decanted sea water;
B) filtering the decanted sea water to obtain a filtered sea water;
C) sterilizing the filtered sea water to obtain a purified sea water;
D) abating boron content in the purified sea water to obtain a sea water with a boron content of less than one milligram per liter;
E) filtering the sea water with a boron content of less than one milligram per liter to obtain a filtered sea water with a boron content of less than one milligram per liter;
F) sterilizing the filtered sea water with a boron content of less than one milligram per liter to obtain a sea water suitable for alimentary use;
G) continuously analysing, examining, and checking of the purified sea water obtained in step C), the sea water with a boron content of less than one milligram per liter in step D), and the sea water suitable for alimentary use in step F), to guarantee that the obtained sea water suitable for alimentary use is purified, filtered, and, hence, free from any pathogenic agent; and
H) storing in tanks or bottling the sea water suitable for alimentary use.

US Pat. No. 10,167,216

HIGH EFFICIENCY WASTEWATER TREATMENT SYSTEM

Gregory D. Graves, Milan...

1. A wastewater treatment plant comprising:a wastewater treatment tank including a top wall, a bottom wall, a front wall, a back wall, a left side wall and a right side wall, the front wall, the back wall, the left side wall and the right side wall being connected together along respective sides and at respective top ends around a bottom side perimeter of the top wall and at respective bottom ends to a top side perimeter of the bottom wall, and having a plurality of interior walls extending between the top, bottom, left side and right side walls and defining a plurality of chambers within the wastewater treatment tank, the plurality of chambers including
a pretreatment chamber having an inlet formed in and extending through a front wall of the pretreatment chamber and the inlet being positioned adjacent to a first side wall and a top end of the front wall of the pretreatment chamber, a pretreatment chamber outlet formed in and extending through a back wall of the pretreatment chamber and adjacent to an opposite side wall and a top end of the back wall of the pretreatment chamber, and a pretreatment chamber access opening formed in and extending through a top wall of the pretreatment chamber;
an anoxic chamber including an anoxic chamber inlet sealingly coupled to and configured for fluid communication with the pretreatment chamber via the pretreatment chamber outlet, an anoxic chamber outlet formed in and extending through a back wall of the anoxic chamber, the back wall being opposite the back wall of the pretreatment chamber;
an aeration chamber including an aeration chamber inlet sealingly coupled to and configured for fluid communication with the anoxic chamber via the anoxic chamber outlet, an aeration chamber outlet opening formed in and near a bottom of a back wall of the aeration chamber opposite the aeration chamber inlet, an aeration chamber access opening formed in and extending through a top wall of the aeration chamber, an aeration chamber riser mounted on the top wall of the aeration chamber and surrounding and covering the aeration chamber access opening, an air pump positioned above the aeration chamber access opening, and a diffusion bar positioned near a bottom of the aeration chamber and attached to and configured for fluid communication with the air pump; and
a clarification chamber including a clarification chamber inlet sealingly coupled to and configured for fluid communication with the aeration chamber via the aeration chamber outlet opening, a clarification chamber outlet opening formed in a back wall of the clarification chamber, a clarification chamber access opening being formed in and extending through a top wall of the clarification chamber, a pump located near the aeration chamber outlet and sealingly coupled to and configured for fluid communication with the anoxic chamber via a piping component; and
a first piping section connected to the pump at a first end and extending upwardly and away from the pump and connecting at a second end to a check valve, which in turn connects to a first end of a second piping section that extends upwardly and through the clarification chamber access opening and is connected at a second end to a first end of a third piping section that extends laterally across the top wall of the clarification chamber and connects at a second end to a first end of a fourth piping section that extends toward the anoxic chamber and is connected at a second end to a first end of a fifth piping section that extends into and toward a bottom of the anoxic chamber and is connected at a second end to an outlet section located near the bottom of the anoxic chamber and that has a plurality of openings defined in the outlet section and that each is configured for fluid communication from an inside of the outlet section to the anoxic chamber.

US Pat. No. 10,167,214

SYSTEM AND METHOD FOR GAS-DISPERSION-RETURN-SLUDGE-BASED WASTEWATER TREATMENT

1. A system for gas-dispersion-return sludge-based wastewater treatment, comprising:a sedimentation vessel into which wastewater comprising inorganic solids and solid organic materials is pumped and in which at least some of the inorganic solids settle from the wastewater;
an adjustment vessel into which the wastewater from the sedimentation vessel is pumped and which comprises anaerobic organisms that solubilize at least some of the solid organic materials within the wastewater;
an aerobic reaction vessel into which the wastewater from the adjustment vessel is pumped and in which the wastewater pumped from the adjustment vessel mixes with a gas-dispersion return sludge to form a mixed liquor, the gas-dispersion return sludge comprising at least one reactive gas a portion of which is dissolved and a portion of which is in a state of ultra-fine bubbles, the gas-dispersion return sludge further comprising aerobic microorganisms that immobilize the solubilized organic materials within the mixed liquor as activated sludge using the at least one dissolved reactive gas, wherein at least some of the ultra-fine bubbles dissolve within the mixed liquor upon a consumption of the dissolved portion of the reactive gases by the aerobic microorganisms;
a sludge sedimentation vessel into which the mixed liquor is pumped from the aerobic reaction vessel and in which the mixed liquor is separated into a supernatant and the activated sludge;
a sludge storage vessel into which the activated sludge from the sludge sedimentation vessel is pumped, wherein at least some of the activated sludge from the sludge collection vessel is pumped to a line atomizer as a return sludge;
a gas generator configured to generate the at least one reactive gas;
the line atomizer configured to form the gas-dispersion return sludge by rendering at least a portion of the at least one reactive gas generated by the gas generator into the ultra-fine bubbles within the return sludge, wherein a portion of the ultra-fine bubbles dissolves within the return sludge, the line atomizer further configured to pump the gas-dispersion return sludge solely into the aerobic reaction vessel; and
a controller interfaced to the sludge storage vessel, the line atomizer, and the gas generator, the controller configured to receive data comprising at least one of a desired degree of purification of the wastewater, a desired speed of purification of the wastewater, and an amount of the wastewater to be purified, and to control the amount of the gas-dispersion return sludge pumped into the aerobic reaction vessel based on the received data.

US Pat. No. 10,167,213

AERATION CONTROL VALVE SYSTEM WITH BYPASS GAS RELEASE PASSAGE FOR WATER TREATMENT SYSTEM AND METHODS FOR USING SAME

R.E. Proscott Co, Inc., ...

1. An aeration control valve system for use with a water treatment tank, the aeration control valve system comprising:a supply water inlet passage configured to receive water from a water supply;
a service water outlet passage configured to direct water to a service water system;
first and second tank passages configured to direct water in to or out of the water treatment tank;
a gas passage fluidly coupled to the first tank passage and configured to allow gas to pass to the water treatment tank;
a drain outlet passage configured to direct water from the water treatment tank to a drain;
a valve cycle actuator configured to provide fluid connections between the passages based on different positions of the valve cycle actuator during different operation cycles; and
a bypass gas release passage extending from a point beyond a flow region of water flowing from the supply water inlet passage and configured to allow gas to be released from the water treatment tank to the gas passage or to the drain outlet passage, during a gas release cycle, while bypassing the water flowing from the supply water inlet passage through the first tank passage.

US Pat. No. 10,167,212

CONTINUOUS FLOW DECONTAMINATION OF AN MTBE-CONTAMINATED AQUEOUS LIQUID

King Fahd University of P...

1. A continuous process for filtering and decontaminating a contaminated aqueous liquid comprising methyl-tert-butyl ether (MTBE), comprising:flowing the contaminated aqueous liquid through at least one selected from the group consisting of a submicron filter, a carbon filter, and an oil filter, to remove particulate matter and long-chain fatty organic molecules, then
flowing the filtered contaminated aqueous liquid while pretreating the contaminated aqueous liquid with chlorine and/or a hypochlorous acid salt to form a chlorinated aqueous liquid comprising 10-50 ppm of chlorine and/or the hypochlorous acid salt, relative to the total mass of the chlorinated aqueous liquid; and
irradiating the chlorinated aqueous liquid with light having a wavelength of about 254 nm from a monochromatic light source that generates a 254 nm wavelength of light or with a polychromatic light source having wavelengths between 200 nm and 370 nm to produce a radical molecular species that degrades the MTBE into at least one degradation byproduct selected from the group consisting of tert-butyl formate (TBF), tert-butyl alcohol (TBA), acetone, carbon dioxide and water and foil is a decontaminated aqueous liquid;
wherein a concentration of MTBE in the contaminated aqueous liquid is higher than a concentration of MTBE in the decontaminated aqueous liquid.

US Pat. No. 10,167,211

FLUID FILTRATION SYSTEM

Green Age Technologies LL...

1. A method of filtering a fluid, comprising:flowing a fluid into a filter assembly in an initial feed flow direction, the fluid containing suspended solids and dissolved impurities, wherein the filter assembly comprises:
a vessel defining a pressure chamber; and
a filter screen with apertures disposed within the vessel, the screen
dividing the pressure chamber into a first subchamber and a second subchamber,
a first pump configured to induce fluid flow from the first subchamber to the second subchamber;
flowing the fluid from the first subchamber to the second subchamber in the feed flow direction;
accumulating at least a portion of the suspended solids in the apertures on the filter screen thereby reducing the effective diameter of the apertures and causing a pressure differential across the filter screen and inducing fluid cavitation in the feed flow direction;
controlling a first pressure of the first subchamber relative to a second pressure of the second subchamber to maintain the fluid cavitation in the fluid flowing in the feed flow direction; and
precipitating out dissolved impurities within the fluid in said first subchamber during the controlled and maintained fluid cavitation.

US Pat. No. 10,167,209

SYSTEM AND METHOD FOR DISINFECTION AND FOULING PREVENTION IN THE TREATMENT OF WATER

DREXEL UNIVERISITY, Phil...

1. A treatment system comprising:a chamber having an inlet and an outlet;
a cathode and an anode located within the chamber for applying a plasma spark discharge to contents of the chamber; and
at least two electrodes located in the chamber for applying an RF oscillating energy field within the chamber.

US Pat. No. 10,167,208

STERILIZATION SYSTEM

LG Electronics Inc., Seo...

1. A sterilization system comprising:a water supply apparatus provided with a filter unit, the filter unit having a plurality of filters configured to purify water supplied from a water supply unit, a water cock through which water purified by the filter unit is dispensed, and connection passages connecting the filter unit and the water cock to each other; and
a sterilizer configured to sterilize the water supply apparatus,
wherein the sterilizer comprises:
a sterilizing water generator that has electrodes and that is configured to generate sterilized water by using the electrodes to electrolyze water filtered by the filter unit;
a circulation pump configured to pump purified water discharged from the water supply apparatus such that the purified water circulates to the sterilizing water generator and returns to the water supply apparatus;
a circulation passage connected to the water cock to define a closed loop for circulation of purified water and sterilized water such that purified water or sterilized water is discharged from the water supply apparatus and circulates back to the water supply apparatus via the circulation pump and the sterilizing water generator; and
a rinsing water supply passage configured to supply water supplied from the water supply unit to the water supply apparatus to wash out the water supply apparatus,
wherein the water supply apparatus comprises a second water tank configured to heat purified water,
wherein the circulation passage extends from the water cock to the circulation pump,
wherein the sterilizer further comprises a first drain passage that is branched out from the circulation passage, the first drain passage having a first side connected to the circulation passage between the water cock and the circulation pump and a second side connected to an outside of the sterilizer, and
wherein the first drain passage is configured to drain out hot water discharged from the second water tank to the outside of the sterilizer based on the second water tank being sterilized.

US Pat. No. 10,167,207

ELECTROLYTIC APPARATUS WITH CIRCULATOR, REVERSE OSMOSIS FILTER, AND COOLER, FOR PRODUCING REDUCING WATER

SAMSUNG ELECTRONICS CO., ...

1. An apparatus for producing reducing water comprising:an electrolytic bath comprising a cathode chamber provided with a cathode, an anode chamber provided with an anode, and an intermediate chamber interposed between the cathode chamber and the anode chamber, wherein the intermediate chamber comprises a cation exchange resin that dissociates hydrogen ions when the cation exchange resin reacts with water; and
a circulator to supply water to the intermediate chamber and supply water discharged through the cation exchange resin to the intermediate chamber again, the circulator comprising a water tank to store water supplied to the intermediate chamber, a channel to enable water present in the water tank to circulate between the intermediate chamber and the water tank, and a pump to circulate water present in the water tank between the intermediate chamber and the water tank;
a reverse osmosis (RO) filter to purify water that is directly supplied to the electrolytic bath and the water tank of the circulator;
a plurality of valves to control flow of water so that the water supplied from the RO filter is supplied directly to one of the cathode chamber and the water tank; and
a cooling apparatus configured to reduce the temperature of the water in the water tank and comprising any one of a fan and a cooler using a refrigerant or a thermoelectric semiconductor, the water in the water tank being from both the RO filter and the circulator,
wherein the cathode chamber and the intermediate chamber are both provided with an inlet through which water is supplied, and an outlet through which water is discharged,
a cation exchange membrane is provided between the cathode chamber and the intermediate chamber, and
the water tank comprises an outlet through which water stored in the water tank is discharged outside.

US Pat. No. 10,167,204

GRAVITY FILTER DESIGNS CONFIGURED FOR INCREASED RESIDENCE TIME

Helen of Troy Limited, S...

1. A water filter pitcher assembly comprising:a pitcher body comprising a pitcher floor and a pitcher sidewall extending from the pitcher floor; and
a pour tray coupled to the pitcher body, the pour tray comprising:
a pour tray floor;
a pour tray sidewall extending upward from the pour tray floor; and
a filter housing extending below the pour tray floor, the filter housing comprising a housing floor, a housing sidewall extending between the housing floor and the pour tray floor, and at least one filter housing outlet disposed along one of more of the housing floor and the housing sidewall;
a filter media cartridge disposed inside the filter housing comprising filter media, wherein the filter media cartridge further comprises a cartridge floor spaced above the housing floor, a cartridge sidewall extending away from the cartridge floor, and at least one filter media cartridge outlet disposed along one or more of the cartridge floor and the cartridge sidewall; and
a riser spaced between the housing sidewall and the cartridge sidewall and extending vertically above the cartridge floor, and wherein the riser forms a conduit volume that surrounds a bottom portion of said cartridge sidewall.

US Pat. No. 10,167,202

ENHANCED METAL RECOVERY THROUGH OXIDATION IN LIQUID AND/OR SUPERCRITICAL CARBON DIOXIDE

KING ABDULLAH UNIVERSITY ...

11. A method comprising: oxidizing a metal-containing feedstock in a reactor with liquid and/or supercritical fluid carbon dioxide and at least one oxidant, wherein the oxidant is free of complexing agent and optionally the metal-containing feedstock is not subjected to ultrafine grinding, wherein aqueous alkali solution is added to the reactor.

US Pat. No. 10,167,200

SYNTHESIS OF MOLECULAR SIEVE SSZ-41

Chevron U.S.A. Inc., San...


US Pat. No. 10,167,198

METHOD FOR PRODUCING FLAKE GRAPHITE, AND FLAKE GRAPHITE

SEKISUI CHEMICAL CO., LTD...

1. A method for producing exfoliated graphite, comprising steps of:preparing a composition which comprises graphite or primary exfoliated graphite and a polymer and in which the polymer is fixed to the graphite or primary exfoliated graphite; and
pyrolyzing the polymer contained in the composition to exfoliate the graphite or primary exfoliated graphite and remove the polymer by burning the polymer off such that it disappears through pyrolysis of the polymer,
wherein in the step of preparing the composition, the polymer is grafted on the graphite or primary exfoliated graphite in the composition in which the polymer is fixed to the graphite or primary exfoliated graphite.

US Pat. No. 10,167,195

CONTINUOUS BORON NITRIDE NANOTUBE FIBERS

BNNT, LLC, Newport News,...

1. A process for producing aligned boron nitride nanotube (BNNT) fibers, the process comprising:feeding nitrogen gas to a chamber at an elevated pressure and flowing the gas through the chamber in a first direction;
thermally exciting a boron feedstock in the chamber to form boron micro-droplets downstream of the boron feedstock in the first direction;
establishing a heat distribution profile to form a BNNT growth zone in the chamber downstream of the boron feedstock in the first direction, wherein BNNTs self-assemble from the boron micro-droplets and nitrogen gas in the growth zone and flow in the first direction; and
establishing a shear force profile in the chamber to align BNNT fibers flowing from the growth zone in the first direction.

US Pat. No. 10,167,192

PERFORATED CONTACT ELECTRODE ON VERTICAL NANOWIRE ARRAY

The United States of Amer...

1. A structure comprising:a support;
a plurality of nanowires perpendicular to the support; and
an electrode in contact with a first end of each nanowire;
wherein each nanowire has a second end in contact with the support; and
wherein the electrode contains a plurality of perforations;
wherein each perforation comprises an open space forming a straight line path normal to the support and completely through the electrode.

US Pat. No. 10,167,191

METHOD FOR MANUFACTURING A MICRO ELECTRO-MECHANICAL SYSTEM

KIONIX, INC., Ithaca, NY...

1. A method of fabricating a semiconductor device, the method comprising:growing a first layer of oxide on a surface of a first semiconductor substrate;
forming a layer of insulating material on the oxide layer;
patterning and etching the insulating material and the first oxide layer to form a plurality of oxide-insulator structures, said etching exposing the surface of the semiconductor substrate;
growing a second layer of oxide in the exposed surface of the semiconductor substrate; and
removing the second layer of oxide thereby to form a cavity in which the semiconductor device is formed.

US Pat. No. 10,167,190

LOW COST WAFER LEVEL PROCESS FOR PACKAGING MEMS THREE DIMENSIONAL DEVICES

The Regents of the Univer...

14. A method for fabrication of lids for a chip-level hermetic packaging of MEMS device of varying shape and form factor, comprising:providing a handle wafer;
creating cavities into a handle wafer;
bonding a cap wafer onto the handle wafer to form a cap-handle wafer stack;
forming a metal hard mask on the handle wafer;
heating the cap-handle wafer stack in a furnace as to allow pressure buildup within the cavity causing plastic deformation of the cap wafer; and
removing portions of the handle wafer defined by the metal hard mask to open the cavity.

US Pat. No. 10,167,189

STRESS ISOLATION PLATFORM FOR MEMS DEVICES

Analog Devices, Inc., No...

18. A MEMS device comprising:a substrate having a stress-relief gap therein defining a MEMS platform and a peripheral region;
a MEMS structure on the MEMS platform; and
at least one flexible electrical conductor electrically coupled to the MEMS structure on the MEMS platform, spanning the stress-relief gap, and physically contacting the peripheral region of the substrate and the MEMS platform, the at least one flexible electrical conductor configured to carry an electrical signal across the stress-relief gap.

US Pat. No. 10,167,188

INTEGRATED PARTICLE FILTER FOR MEMS DEVICE

Apple Inc., Cupertino, C...

1. A micro-electro-mechanical system (MEMS) transducer comprising:an enclosure defining an interior space and having an acoustic port formed through one side of the enclosure;
a compliant member positioned within the interior space and acoustically coupled to the acoustic port, the compliant member being configured to vibrate in response to an acoustic input;
a back plate positioned within the interior space, the back plate being positioned along one side of the compliant member in a fixed position; and
a filter positioned between the compliant member and the acoustic port, wherein the filter comprises a plurality of material layers that define a plurality of axially oriented pathways and a plurality of laterally oriented pathways which are acoustically interconnected, the plurality of axially oriented pathways extending through the plurality of material layers and the plurality of laterally oriented pathways extending between the plurality of material layers, and a first axially oriented pathway of the plurality of axially oriented pathways is axially offset with respect to a second axially oriented pathway of the plurality of axially oriented pathways.

US Pat. No. 10,167,187

PHYSICAL QUANTITY SENSOR HAVING AN ELONGATED GROOVE, AND MANUFACTURING METHOD THEREOF

Seiko Epson Corporation, ...

1. An electronic device comprising:a substrate; and
a first functional element disposed on the substrate and having a sensor and an outer edge,
wherein the sensor includes all sensing portions, wiring, and electrodes for the first functional element, and the outer edge is defined by an imaginary line encircling the sensor having all sensing portions, wiring, and electrodes, the outer edge being the portion of the first functional element outside of the imaginary line in a plan view, and
wherein the outer edge includes at least two separate first grooves formed spaced apart in a top surface of the outer edge of the first functional element, each of the first grooves being elongated in a first direction in the plan view, and each of the first grooves being vacant.

US Pat. No. 10,167,186

METHOD AND APPARATUS FOR THE PRODUCTION OF A POCKETED SPRING UNIT

Harrison Spinks Component...

1. A method for the production of a pocketed spring, the method comprising the steps of, at each step-wise advancement feeding, in the direction of advancement, a row of pre-compressed springs into positions between upper and lower layers of fabric or other material using a spring inserter, step-wise advancing said material and said springs and then welding together said lengths of fabric or other material so as to encapsulate a row of springs in a plurality of discrete pockets each containing a spring at each step-wise advancement, each row being oriented substantially perpendicularly to the direction of advancement.

US Pat. No. 10,167,185

FILLING ADAPTER HAVING A COAXIAL VALVE

1. A filling adapter for the initial filling of vehicle containers with operating substances during vehicle manufacturing, wherein the filling adapter is equipped with a hose pack, wherein the filling adapter is equipped with a coaxial valve in the region of its adapter head, which coaxial valve, starting from the inlet cross section, is initially provided with a first flow contour extending parallel to a longitudinal axis of the valve, the adapter head having a body with a ninety degree bend such that the first flow contour transitions to a second flow contour that extends at a right angle to the longitudinal axis of the valve towards the outlet cross section, wherein a circular conical deflector plate is fixedly mounted to an inner wall of the adapter head at the transitional section from the first flow contour extending in parallel to the longitudinal axis of the valve to the second flow contour extending at a right angle to the longitudinal axis of the valve.

US Pat. No. 10,167,184

MULTIPLE BEVERAGE DISPENSING COOLER

1. A portable beverage dispenser, comprising:an insulated cooler body having a cooler body interior;
a lid removably secured over a cooler body open top;
a handle assembly affixed to a cooler body first sidewall;
an ice reservoir located within said cooler body interior, having an ice reservoir interior;
an ice dispenser in operable communication with said ice reservoir interior and in fluid communication with an ice dispenser opening disposed within a cooler body second sidewall;
at least one beverage dispensing assembly, each comprising:
a beverage reservoir located within said cooler body interior and outside said ice reservoir; and,
a dispensing device in operable communication with said beverage reservoir and in fluid communication with a beverage dispensing opening located on said cooler body second sidewall;
at least one drawer slidably engaging with said cooler body second sidewall;
a cup dispenser affixed to a cooler body third sidewall; and,
a drink stirrer affixed to said cooler body third sidewall adjacent said cup dispenser.

US Pat. No. 10,167,183

SYSTEM AND METHOD FOR BEVERAGE DISPENSING

SESTRA SYSTEMS, INC, Ste...

1. A method of controlling fluid flow through a reciprocating piston metering dispenser comprising:a. calibration of piston travel time for minimal system pressure and maximum system pressure;
b. calibration of piston delay time for minimal system pressure and maximum system pressure; and
c. controlling piston start and stop based upon calculation of piston termination location taking into account changes in pressure between reciprocation according to said calibrations;wherein successive discharges from said metering dispenser as urged by said piston provides for a fluid communication output with a continuous metered discharge.

US Pat. No. 10,167,182

VACUUM SIDE AIR VENT

The Coca-Cola Company, A...

1. A method for removing air within an air chamber, comprising:receiving a flow of a fluid at a first port of the air chamber from a fluid source in fluid communication with the air chamber;
dispensing the fluid at a second port of the air chamber; and
reversing the flow to draw the fluid into the air chamber to purge air within any one of the air chamber and the fluid source through a third port by reversing a pump.

US Pat. No. 10,167,181

HYDRAULIC STEERING SHEAR-FORK TYPE AERIAL WORK PLATFORM

CHEJIANG DINGLI MACHINERY...

1. A hydraulic steering shear-fork aerial work platform comprising a running chassis and a lifting device, wherein:the running chassis comprises:
a chassis body; and
a running device comprising a left steering wheel, a right steering wheel, a left wheel carrier, a right wheel carrier, a linkage frame, and a steering oil cylinder, wherein the left steering wheel and the right steering wheel are respectively installed on the left wheel carrier and the right wheel carrier, and wherein the left wheel carrier and the right wheel carrier are rotatably installed on the chassis body through wheel carrier shafts;
wherein the running chassis is characterized in that two ends of the linkage frame are respectively hinged to the left wheel carrier and the right wheel carrier;
wherein the linkage frame further comprises a steering oil cylinder installing portion for a first end of the steering oil cylinder to be installed; and wherein a second end of the steering oil cylinder is connected with at least one of the wheel carrier shafts through an installing plate, so that the left steering wheel and the right steering wheel turn towards a first side when the steering oil cylinder is controlled to extend, and the left steering wheel and the right steering wheel turn towards a second side when the steering oil cylinder is controlled to withdraw;
wherein the lifting device comprises a shear fork lifting structure and a lifting platform, wherein the shear-fork lifting structure is formed by connecting a plurality of shear-fork units, and wherein a first bottom end of each shear-fork unit is hinged to the running chassis, and a second end of each shear-fork unit is hinged to a sliding block that is in sliding fit with the running chassis;
wherein the lifting device further comprises a lifting detection and control system comprising a potentiometer installed on a rotation shaft of the shear-fork lifting structure and a controller, wherein any lifting height corresponds to a unique rotating angle of the rotation shaft, wherein the potentiometer is configured to correspond to a unique resistance value corresponding to all heights recorded in the controller, and wherein a limit on a lifting height of the lifting device is configured to be achieved by setting a resistance value correlated with the limit on the lifting height of the lifting device.

US Pat. No. 10,167,180

ADJUSTABLE PALLET FORKS

1. A pallet loading attachment for a vehicle, the pallet loading attachment removably coupled to the vehicle, the attachment comprising:a frame, the frame having a first end, the first end aligned proximal to the vehicle for attachment, the first end having a universal quick attach, and a second end opposite the first end and distal to the vehicle;
a pair of pallet forks, the pallet forks movably received within the frame and extending outward opposite the first end, the pallet forks sized for receipt within a pallet, the pallet forks each spaced a width, wherein the width defines a distance between each pallet fork;
a wheel, the wheel centrally positioned on a lower side of the frame, the wheel positioned a height above a bottom of the pallet forks, and the wheel positioned in selective communication with a ground surface, wherein the wheel height is above a ground surface when the pallet forks are leveled upon the ground surface and wherein the wheel is contacted with the ground surface when the pallet forks are tilted in an upwards direction opposite the ground surface; and
a threaded rod, the threaded rod forming an axle of the wheel and having opposed threads aligned on opposed sides of the wheel, the threaded rod having opposed ends, the opposed ends in communication with each pallet fork, wherein movement of the wheel adjusts the width between each pallet fork.

US Pat. No. 10,167,179

JACK SYSTEM

KURTJAN JACKS (PTY) LTD.,...

1. A jack system for selectively raising or lowering one or more structures from a first position to a second position and back from said second position to said first position, comprising:a fixed support structure;
at least two opposing and spaced apart jacks, each jack comprising a pair of arms longitudinally spaced apart from each other wherein each pair of arms has lower end portions and upper end portions, wherein said lower end portions are movably connected to said fixed support structure, and wherein said arms extend upwardly at predetermined angles with respect to said fixed support structure;
a pair of longitudinally extending support members fixedly mounted upon central portions of said pair of arms so as to support one or more structures disposed transversely with respect to said pair of longitudinally extending support members; and
retractable and extensible mechanisms operatively connected to said upper end portions of each one of said pair of arms such that as said retractable and extensible mechanisms are retracted, said upper end portions of each one of said pair of arms are drawn together so as to cause each one of said pair of arms to pivotally move said lower end portions of said pair of arms relative to said fixed support structure and thereby elevate said pair of longitudinally extending support members so as to, in turn, elevate the one or more structures supported upon said pair of longitudinally extending support members, whereas when said retractable and extensible mechanisms are extended, said upper end portions of each one of said pair of arms are moved apart from each other so as to thereby cause each one of said pair of arms to pivotally move said lower end portions of said pair of arms relative to said fixed support structure and thereby lower said pair of longitudinally extending support members so as to, in turn, lower the one or more structures supported upon said longitudinally extending support members.

US Pat. No. 10,167,178

LEVELING JACK WITH DIRECT ACTUATION

LIPPERT COMPONENTS, INC.,...

1. A jack comprising:a first lifting section, the first lifting section comprising:
a first cross beam;
a first trunnion engaged with the first cross beam and selectively displaceable in first and second displacement directions with respect to the first cross beam between a first trunnion position and a second trunnion position;
a first leg pivotally connected to the first trunnion; and
a first brace pivotally connected to the first leg and pivotally connected to the first cross beam;
a first drive mechanism operably engaged with the first trunnion, the first drive mechanism configured to selectively displace the first trunnion in the first and second displacement directions with respect to the first cross beam, the first drive mechanism comprising:
a first drive screw;
a first drive nut threadingly engaged with the first drive screw; and
a first drive plate engaged with the first drive nut and the first trunnion such that a first portion of the drive screw is received within the first drive nut and a second portion of the drive screw spaced apart from the first portion of the drive screw is received within the first trunnion, such that rotation of the first drive screw in a first direction of rotation results in displacement of the first drive nut, the first drive plate, and the first trunnion in the first displacement direction with respect to the first cross beam; and such that rotation of the first drive screw in a second direction of rotation results in displacement of the first drive nut, the first drive plate, and the first trunnion in the second displacement direction with respect to the first cross beam.

US Pat. No. 10,167,177

CRANE, AND CRANE CONTROL METHOD

1. A crane including travel devices which are arranged on opposite sides with a gap in a transverse direction crossing a travel direction and a crane structure which is supported by the travel devices, the travel devices each including a travel wheel, a motor which transmits power to the travel wheel, an inverter which is connected to the motor and which controls a rotation speed of the motor, and a controller which gives a command of the rotation speed to the motor via the inverter, whereineach of the inverters includes a torque measurement unit which measures a torque generated in the motor to which the inverter is connected and a control unit which reduces the rotation speed in the command from the controller to the motor such that the greater a value of the torque obtained by the torque measurement unit is, the greater a ratio of reduction with respect to the rotation speed in the command is,
a control of each of the control units is performed within a range in which a ratio of the torque measured by the torque measurement unit is greater than 0% and less than 150% with respect to a rated torque of the motor to which the inverter is connected, and
the inverters independently perform measurement with the torque measurement units and the control with the control units.

US Pat. No. 10,167,176

AUTOMATIC ERECTING OF A CRANE

1. A method for automatic telescoping of a boom system of a crane having at least one telescopic boom, and having a rope and a winch for pivoting the boom, the method comprising:measuring with a first sensor an actual value of a boom angle of the boom forming an acute angle relative to a horizontal plane;
actuating, automatically, the winch based on the measured boom angle;
measuring with a second sensor an actual value of a guying frame angle of a guying frame forming an acute angle relative to the horizontal plane;
determining, based on the measurements of the boom angle and the guying frame angle, an intermediate angle between the guying frame and the boom; and
actuating, automatically, the winch based on the intermediate angle between the guying frame and the boom, and wherein the crane is a mobile crane.

US Pat. No. 10,167,175

CLAMPING APPARATUS

1. A beam clamping and supporting apparatus, comprising:a first yoke defining a first wedge slot transversely extending across an upper portion of the first yoke, the first yoke comprising a first inwardly extending support arm defining a first beam support surface;
a second yoke defining a second wedge slot transversely extending across an upper portion of the second yoke, the second yoke pivotally coupled to the first yoke with a pivot member extending through the first and second yokes above the first and second wedge slots and having a second support arm inwardly extending toward and laterally spaced from the first support arm, the first and second support arms defining a space for receiving a portion of an elongate beam therein between with the second support arm defining a second support surface, the first and second support surfaces extending under and supporting the portion of the elongate beam when coupled thereto when the first and second wedge slots are substantially aligned; and
a wedge extending through the first and second wedge slots when the first and second wedge slots are substantially aligned, the wedge transversely extending relative to the first and second yokes and substantially parallel to the pivot member so as to be in alignment with a long axis of the beam thereby holding the beam between a bottom surface of the wedge and the first and second support surfaces of the first and second support arms, respectively.

US Pat. No. 10,167,173

PRIORITIZING THE DIRECTION OF A DIRECTIONAL PEDESTRIAN MOVER (DPM) IN REAL TIME, BASED ON PREDICTED PEDESTRIAN TRAFFIC FLOW

International Business Ma...

1. A computer-implemented method to prioritize a direction of movement of a directional pedestrian mover (DPM) based on predicted pedestrian traffic flow, the method comprising:obtaining, by a pedestrian flow detector, a first predicted pedestrian traffic flow relative to the direction of movement of the DPM, and a second predicted pedestrian traffic flow in a different direction relative to the first predicted pedestrian traffic flow, the pedestrian flow detector receiving information from a plurality of sensors,
wherein a majority of the first, or second, predicted pedestrian traffic flow may include a threshold value of a group of detected pedestrians;
calculating, by a pedestrian arrival time calculator, a time for a majority of the first predicted pedestrian traffic flow, and a majority of the second predicted pedestrian traffic flow, to reach at least one access point of the DPM, the pedestrian arrival time calculator receiving information from the plurality of sensors,
wherein changing the direction of movement of the DPM is based on determining that the time for the majority of the second predicted pedestrian traffic flow to reach the at least one access point of the DPM is less than the time for the majority of the first pedestrian traffic flow to reach the at least one access point of the DPM;
obtaining, by the plurality of sensors, an average pedestrian density information, for the majority of the first predicted pedestrian traffic flow, and the majority of the second predicted pedestrian traffic flow, from respective locations and to at least one access point of the DPM;
obtaining, by the plurality of sensors, an average pedestrian travel speed, for the majority of the first predicted pedestrian traffic flow, and the majority of the second predicted pedestrian traffic flow, from the respective locations and to the at least one access point of the DPM;
obtaining, by the plurality of sensors, estimated distance information, for the majority of the first predicted pedestrian traffic flow, and the majority of the second predicted pedestrian traffic flow, from the respective locations and to the at least one access point of the DPM;
obtaining, by the pedestrian arrival time calculator, one or more schedule of events, at a given venue, that may affect the majority of the first predicted pedestrian traffic flow, and the majority of the second predicted pedestrian traffic flow, from the respective locations and to the at least one access point of the DPM; and
obtaining, by the pedestrian arrival time calculator, an estimated direction of the majority of the first predicted pedestrian traffic flow, and an estimated direction of the majority of the second predicted pedestrian traffic flow, from the respective locations and to the at least one access point of the DPM;
determining, by the pedestrian arrival time calculator, a first time factor by dividing estimated distance information, for the majority of the first predicted pedestrian traffic flow, by an average pedestrian travel speed, for the majority of the first predicted traffic flow;
determining, by the pedestrian arrival time calculator, a second time factor by dividing estimated distance information, for the majority of the second predicted pedestrian traffic flow, by an average pedestrian travel speed, for the majority of the second predicted traffic flow;
adding, by the pedestrian arrival time calculator, an additional time factor to the second time factor to accommodate the time it takes to change the direction of movement of the DPM;
adding, by the pedestrian arrival time calculator, an additional time factor to the second time factor to accommodate the time it takes for all pedestrians on the DPM to exit the DPM before changing the direction of movement of the DPM;
determining, by a processor, that the second predicted pedestrian traffic flow exceeds the first predicted pedestrian traffic flow;
determining, by the processor, that the time for the majority of the second predicted pedestrian traffic flow to reach the at least one access point of the DPM is less than the time for the majority of the first pedestrian traffic flow to reach the at least one access point of the DPM, the processor comprising executable instructions for:
providing a warning, using visual, audio, or other indicators, that the direction of movement of the DPM is about to change;
closing at least one access point to the DPM; and
changing the direction of movement of the DPM to accommodate the second predicted pedestrian traffic flow, based on the determining that the time for the majority of the second predicted pedestrian traffic flow to reach the at least one access point of the DPM is less than the time for the majority of the first pedestrian traffic flow to reach the at least one access point of the DPM.

US Pat. No. 10,167,172

PASSENGER CONVEYOR WITH DEEP SLEEP MODE

Kone Corporation, Helsin...

1. A passenger conveyor comprising:a conveyor motor;
a motor drive configured to drive the conveying motor, the motor drive including,
a frequency converter with a rectifier bridge, the rectifier bridge connected to mains via at least one relay,
an intermediate DC circuit, and
a converter bridge connected with the conveyor motor;
a conveying controller configured to control the passenger conveyor by setting the passenger conveyor to a deep sleep mode by opening a main relay and a charging relay of the at least one relay to switch off the frequency converter and at least a portion of the conveying controller;
a signaling circuit configured to remain powered during the deep sleep mode; and
a wake-up circuit connected to the signaling circuit, the wake-up circuit configured to remain powered at least during the deep sleep mode, the wake-up circuit configured to close the charging relay in response to a signal from the signaling circuit.

US Pat. No. 10,167,171

ELEVATOR WITH BRAKE DEVICE IN THE MANNER OF A CLAMP BRAKE

Wittur Holding GmbH, Wie...

1. An elevator with a brake device for braking a car, or for keeping the car stationary on at least one braking rail, or for both braking the car and keeping the car stationary on at least one braking rail, the brake device comprising:at least two brake shoes situated opposite from each other; and
at least one brake clamp with two clamp arms for opening and closing clamp jaws acting on the brake shoes, wherein only a first clamp arm of the at least one brake clamp is connected to the car in pivoting fashion via a bearing with a pivot axle that is affixed to the car, oriented parallel to a direction of travel, and a second clamp arm of the brake clamp is not affixed at any point relative to the car so that the second clamp arm is able to execute a movement relative to the car, even a movement with a translatory component.

US Pat. No. 10,167,170

SMART ELEVATOR SYSTEM

MFS CORPORATION, Guro-gu...

1. A smart elevator system comprising:an elevator provided in a building having multiple floors;
a controller configured to control the elevator;
a portable terminal used by a person to make a reservation for using the elevator and comprising a communicator for long-range communication and short-range communication;
a server system configured to receive the reservation for using the elevator from the portable terminal by communicating with the portable terminal and control an operation of the elevator through the controller according to the reservation; and
a portable terminal detector provided near a door of the elevator and configured to obtain a unique key of the portable terminal through the communicator, when the portable terminal used to make the reservation approaches it,
wherein a security control box is embedded in the elevator and is configured to determine whether a person getting into the elevator is the person who made the reservation and move the elevator when it is determined that the person getting into the elevator is the person who made the reservation.

US Pat. No. 10,167,169

REEL, METHOD OF MANUFACTURING THE SAME, AND METHOD OF MANUFACTURING REEL COMPONENT MEMBER

FUJIFILM CORPORATION, To...

1. A reel comprising:a bottomed circular tube shaped hub that has an outer peripheral face for winding a recording tape around;
a first flange that is integrally molded to one end portion of the hub;
a second flange that is joined to another end portion of the hub;
a plurality of hole portions that are provided at equal intervals on a ring shaped reel gear formed at a lower face of a bottom plate of the hub; and
a gate mark that is formed at the bottom plate of the hub, further to a radial direction inside than an inner peripheral face of the hub,
wherein a difference in surface roughness between a weld portion and a non-weld portion on the outer peripheral face of the hub is 0.25 ?m or less,
wherein the hub is formed by a resin material, the weld portion, that is a portion where a melted resin material converged when the hub was molded, is formed on the outer peripheral face of the hub, and another portion excluding the weld portion on the outer peripheral face of the hub is the non-weld portion.

US Pat. No. 10,167,168

CASTING REEL SUPPORTING DEVICE

1. A casting reel spooling device, comprising:a base;
a vertical support arm affixed to and extending away from an upper side of said base;
a first horizontal support arm, having a first end removably secured to said vertical support arm;
a second horizontal support arm, having a first end removably secured to said vertical support arm;
a first plurality of spool sleeves, each disposed on and capable of traversing along said first horizontal support arm;
a plurality of first pairs of flanged friction fittings bracketing an individual one of said first plurality of spool sleeves, each first pair of flanged friction fittings capable of traversing along said first horizontal support arm;
a first compression spring disposed on said first horizontal support arm between said vertical support arm and a flanged friction fitting from said first pair of flanged friction fittings most adjacent to said vertical support arm;
a first locking collar removably secured to said first horizontal support arm;
a second plurality of spool sleeves, each disposed on and capable of traversing along said second horizontal support arm;
a plurality of second pairs of flanged friction fittings bracketing an individual one of said second plurality of spool sleeves, each second pair of flanged friction fittings capable of traversing along said second horizontal support arm;
a second compression spring disposed on said second horizontal support arm between said vertical support arm and a flanged friction fitting from said second pair of flanged friction fittings most adjacent to said vertical support arm; and,
a second locking collar removably secured to said secured horizontal support arm;
wherein said first and second horizontal support arms are disposed parallel to each other;
wherein each of said first plurality of spool sleeves and each of said plurality of second support sleeves is capable of supporting a fishing line spool reel thereupon;
wherein each of said first plurality of spool sleeves and each of said plurality of first pairs of flanged friction fittings are capable of free rotation about said first horizontal support arm;
wherein said first locking collar provides a restrictive force against rotation of and said first compression spring provides continuous tension to each fishing line spool reel when installed on said first horizontal support arm;
wherein each of said second plurality of spool sleeves and each of said plurality of second pairs of flanged friction fittings are capable of free rotation about said second horizontal support arm; and,
wherein said second locking collar provides a restrictive force against rotation of and said second compression spring provides continuous tension to each fishing line spool reel when installed on said second horizontal support arm.

US Pat. No. 10,167,166

IMAGE FORMING APPARATUS

Canon Kabushiki Kaisha, ...

1. An image forming apparatus forming an image on a sheet, the apparatus comprising:an exterior member configured to open and close with respect to an apparatus main body;
a locking portion configured to lock the exterior member to the apparatus main body such that the exterior member is not moved with respect to the apparatus main body; and
a light source configured to emit light;
wherein the exterior member includes a thin portion which is made of the same material as other portions of the exterior member and is thinner than thicknesses of the other portions of the exterior member, and which allows penetration of the light from the light source so that the exterior member displays a status of the locking portion by the light penetrating at the thin portion.

US Pat. No. 10,167,164

HANDHELD TAPE DISPENSER

Huah Jinn Tape Searching ...

1. A handheld tape dispenser comprising:a first shell including a front opening, a tongue member, a top opening, a first hollow cylindrical member, a second hollow cylindrical member, a first rib, two second ribs with the first rib disposed therebetween, a receptacle, and a groove;
a second shell releasably secured to the first shell and including a front opening, a tongue member, a top opening, a receptacle, a first hollow cylindrical member joined the first hollow cylindrical member of the first shell, a longitudinal ridge, and a groove;
a spring-actuated tape applying mechanism including a frame, an oval opening with the second hollow cylindrical member projecting through, a cavity adjacent to the oval opening, and a pin; a button disposed on both the top opening of the first shell and the top opening of the second shell; a pressing member under the button; a projection under the pressing member; a front platform on both the receptacle of the first shell and the receptacle of the second shell, the front platform having a plurality of ridges on a top surface; a tape core supported by the second ribs and having two aligned groove members on a bottom, the groove member being slidably placed on the first rib; and two wings on two sides of the button respectively, the wings slidably disposed in the groove of the first shell and the groove of the second shell respectively;
a knife supported by the projection and including two front blades, a rear hollow cylinder pivotably put on the second hollow cylindrical member, a peg projecting downward from a bottom of the rear hollow cylinder into the cavity, a protuberance under the button, a first protrusion on an underside of the knife, and a second protrusion on the underside of the knife and being forward of the first protrusion;
a roll of tape wound convolutedly on the tape core and including an adhesive tape extending therefrom;
a roller member put on the pin; and
a tape press roller put on both the first hollow cylindrical member of the second shell and the first hollow cylindrical member of the first shell;
wherein the adhesive tape frictionally passes an outer surface of the roller member and a gap between the front platform and the tape press roller to extend out of both the front opening of the first shell and the front opening of the second shell;
wherein the longitudinal ridge presses the roll of tape;
wherein the peg is slidably disposed in the cavity;
wherein a rearward movement of the button moves both the front platform and the pressing member rearward to uncover both the receptacle of the first shell and the receptacle of the second shell, urge the pressing member against the protuberance, pivot the knife relative to the rear hollow cylinder, cause the first protrusion to press the adhesive tape against the ridges of the front platform, engage the second protrusion with the adhesive tape, move the blades downward into the receptacles to sever the adhesive tape, and adhesively secure a front end of the adhesive tape within both the first and second shells to the ridges of the front platform.

US Pat. No. 10,167,163

HANDOFF MECHANISM FOR A MEDIA PRODUCTION APPARATUS

Hewlett-Packard Developme...

1. A handoff mechanism for use with a media stacker of a media production apparatus, the handoff mechanism comprising:a plurality of kicker units arranged across a width of the handoff mechanism;
a common drive mechanism to move the plurality of kicker units between a closed position and an open position;
whereby each kicker unit, when in the closed position during use, applies a pressure to any media sheets that are already stacked in a stacker tray while a new media sheet is being fed to the stacker tray, and wherein the pressure provided by each kicker unit is independent of the pressure provided by the other kicker units.

US Pat. No. 10,167,161

CONVEYANCE PATH SWITCHING MODULE AND PAPER SHEET HANDLING APPARATUS EQUIPPED THEREWITH

Masterwork Automodules Te...

1. A conveyance path switching module, comprising:a main body, having a first conveyance path, a second conveyance path and a third conveyance path adapted to convey an object; and
a switching mechanism, comprising:
a first switching assembly, pivoted to the main body; and
a second switching assembly, pivoted to the main body,
wherein by pivotally turning of the first switching assembly and pivotally turning of the second switching assembly, the switching mechanism is adapted to be switched to a first state to open the first conveyance path and close the second conveyance path and the third conveyance path, adapted to be switched to a second state to open the second conveyance path and close the first conveyance path and the third conveyance path, and adapted to be switched to a third state to open the third conveyance path and close the first conveyance path and the second conveyance path,
wherein the first switching assembly comprises a first switching guide and a first shaft, the first switching guide is pivoted to the main body with the first shaft, the second switching assembly comprises a second switching guide, a third switching guide and two second shafts, the second switching guide and the third switching guide are pivoted to the main body respectively with the two second shafts,
wherein the second switching assembly further comprises a third shaft and two linking rods, the second switching guide and the third switching guide are pivoted to each other with the third shaft, and the two second shafts are connected to the third shaft respectively with the two linking rods.

US Pat. No. 10,167,160

TEMPORARY PAPER MONEY STORAGE DEVICE AND CONTROL METHOD THEREOF

GRG BANKING EQUIPMENT CO....

1. A banknote temporary storage device, comprising:a storage coiling block driven by a motor,
a first sensor,
a second sensor and
a conveying passage, wherein
the first sensor is arranged at an entrance of the banknote temporary storage device, and configured to detect whether there is a banknote entering into the banknote temporary storage device;
the second sensor is arranged between the first sensor and the storage coiling block, and configured to detect whether a banknote completely enters into the banknote temporary storage device; and
the conveying passage is located between the first sensor and the second sensor, and configured to convey banknotes to the banknote temporary storage device at a constant speed V,
wherein the banknote temporary storage device further comprises:
a timing unit, configured to obtain a time period ?t1 between a time when the front end of a banknote enters into the first sensor and a time when the back end of the banknote leaves the first sensor;
a calculating unit, configured to calculate a width W of the banknote based on the time period ?t1 obtained by the timing unit, calculate a bump radius Rbump of the storage coiling block where a bump is to be generated, based on the width W, and determine a condition of generating a bump on the storage coiling block based on the bump radius Rbump;
a detecting unit, configured to detect whether the condition of generating a bump on the storage coiling block is met, based on a real-time radius Rreal-time of the storage coiling block; and
an interval control unit, configured to change an interval d between banknotes on the storage coiling block in a pre-set control manner to eliminate a bump, in a case that the detecting unit detects that the condition of generating a bump on the storage coiling block is met.

US Pat. No. 10,167,159

APPARATUS AND METHODS FOR TRANSPORTING WEBS OF MATERIAL

Curt G. Joa, Inc., Shebo...

1. A system comprising:a conveyor comprising a material surface for moving a web material along a transfer path;
a plurality of holes formed through the material surface, the plurality of holes in fluid communication with a cavity;
a fan plate for drawing air out of the cavity to cause air to flow through the holes and into the cavity, the fan plate being oriented substantially perpendicular to the conveyor;
wherein the fan plate is driven by the conveyor.

US Pat. No. 10,167,158

SLITTER DEVICE

TSUDAKOMA KOGYO KABUSHIKI...

1. A slitter device comprising:a let-off mechanism having a let-off driving unit on which a raw-cloth roller formed by winding up an elongated sheet material in a roll shape is mounted, and which has a let-off driving motor as a driving source for rotationally driving the raw-cloth roller;
a cutter device for dividing the sheet material fed out from the let-off mechanism in a width direction of the sheet material to form a plurality of divided sheet materials, having a plurality of disk-shaped rotary blades provided according to the number of divisions of the sheet material, and having a support roll to which the rotary blade is pressed and around which the sheet material is wound;
a take-up mechanism having a winding shaft on which a plurality of take-up reels for winding up each of the divided sheet materials are supported, and having a take-up driving unit which has a take-up driving motor as a driving source for rotationally driving the winding shaft;
a drive control device or control device for controlling the driving of the let-off driving unit and the take-up driving unit, which performs the drive control of one of the let-off driving unit and the take-up driving unit as a tension control and performs the drive control of the other as a speed control;
a roll driving motor that is connected to the support roll to rotationally drive the support roll;
a first tension detecting unit for obtaining a raw-cloth tension value which is a tension value of the sheet material fed out from the let-off mechanism; and
a second tension detecting unit for obtaining the divided material tension value which is the sum of the tension values of each of the divided sheet materials,
wherein the drive control device includes a comparator to which the first tension detecting unit and the second tension detecting unit are connected, and which compares the raw-cloth tension value and the divided material tension value with each other, and a drive controller which controls an operating state of the roll driving motor such that the raw-cloth tension value and the divided material tension value coincide or substantially coincide with each other based on the comparison result of the comparator.

US Pat. No. 10,167,157

STATION FOR INSPECTING ROLLED STRIPS IN COILS

1. A station for inspecting rolled strips wound in coils, comprising:a first pair of mutually opposed pinch rolls, adapted to receive a rolled strip from a coil;
a carriage sliding between a first start position, near said first pair of pinch rolls, and a second end position, said sliding carriage comprising a gripping member to grasp said rolled strip coming from said first pair of pinch rolls;wherein at least one of the rolls of said first pair of pinch rolls is mounted on a swinging arm movable between:a first raised position near said coil wherein said at least one roll of said first pair of pinch rolls is adapted to intercept a free end of said strip, and
a second lowered position near the other roll of said first pair of pinch rolls wherein said free end is gripped between said first pair of pinch rolls.

US Pat. No. 10,167,156

VACUUM COMMUTATION APPARATUS AND METHODS

Curt G. Joa, Inc., Shebo...

2. A system for processing a web, the system comprising:a rotating external porous roll rotating at a first rotational speed;
a rotating internal vacuum manifold communicatively coupled with at least a portion of said rotating external porous roll, said rotating internal vacuum manifold rotating at a variable rotational speed, from a second speed less than said first rotational speed, to said first rotational speed, to a third speed greater than said first rotational speed.

US Pat. No. 10,167,155

FIXTURE TO SUPPORT REEL-TO-REEL INSPECTION OF SEMICONDUCTOR DEVICES OR OTHER COMPONENTS

Raytheon Company, Waltha...

1. An apparatus comprising:a fixture configured to receive multiple reels that are each configured to receive a tape in or on which components to be inspected are located;
wherein the fixture comprises:
a base configured to be secured to a support;
a shaft;
one or more motors mounted to the shaft and configured to rotate the reels; and
one or more joints coupling the shaft and the base, wherein the one or more joints are configured to allow (i) rotation of the shaft about a longitudinal axis of the shaft to change an orientation of the shaft with respect to the base and (ii) rotation of the shaft to change a direction at which the shaft extends away from the base such that the tape is movable into and out of a path of radiation that is generated by a radiation source.

US Pat. No. 10,167,154

VACUUM SYSTEM FOR SECURING ITEMS IN PRINTING MACHINES

1. A vacuum system for securing items in printing machines, comprising a printing table having a perforated surface, in relation to which there is arranged a vacuum system for securing on said printing table the items to be printed, wherein the vacuum system comprises a box structure connected through nozzles with a suction system from the intermediate area of its transversal width, said box structure having an upper perforated wall opposite the perforated surface of the printing table, whereas in the interior thereof there are arranged lateral panels that vertically close in a sealed manner said interior of the box structure, which lateral panels can be moved transversally to move them closer to and farther away from one another inside the box structure, an actuation system being linked to said panels in order to move them,wherein a longitudinal extension of the box structure is divided into a plurality of independent successive chambers in which different vacuum pressures are applied for securing items to be printed, a first force being applied in an inlet area where the items are positioned on the printing table, a second force weaker than the first force being applied in a printing area where the items are printed, and a third force weaker than the second force being applied in a removal area where the items that are removed after having been printed.

US Pat. No. 10,167,153

MEDIA INFEED METAL DETECTION

NCR Corporation, Atlanta...

1. A media infeed module, comprising:an infeed mouth;
a media track adjacent the infeed mouth defining a pathway of a media item;
a media transport for transporting the media item along the media track;
a pinch mechanism adjacent the infeed mouth for pinching the media item against the track when the media item is at the infeed mouth;
a metal detection sensor adjacent the infeed mouth;
a processor; and
an infeed controller;
wherein the infeed controller is configured to: i) execute on the processor, ii) receive metal detection readings from the metal detection sensor, including baseline metal detection readings before the pinch mechanism is activated to pinch the media item at the infeed mouth, iii) calculate a maximum metal detection value based on the baseline metal detection readings, preconfigured threshold values, and ongoing variations in resistance and inductance values provided by the metal detection sensor, and iv) determine based on the maximum metal detection value whether to: a) transport the media item along the track, b) stop transportation of the media item within the media depository, or c) transport the media item out the infeed mouth.

US Pat. No. 10,167,152

FOLDED MEDIA DETECTION AND PROCESSING

NCR Corporation, Atlanta...

1. A method, comprising:detecting a folded media condition using a media thickness sensor within a media separator module for an item of media; and
selectively determining whether to eject the item from the media separator module or whether to perform double feed recovery processing on the item within the media separator module based on the detected folded media condition.

US Pat. No. 10,167,150

FEEDER SYSTEM FOR FEEDING A STACK OF FLAT ELEMENTS TO A PROCESSING DEVICE

BOBST GRENCHEN AG, (CH)

1. A feeder system for feeding a stack of stackable flat elements, to a processing device, the feeder system comprising:a delivery ramp which comprises a receiving surface configured to receive thereon an edge portion and a center portion of the stack;
a transport device comprising a supporting platform configured to support at least a further edge portion of the stack;
wherein the supporting platform is arranged adjacent to the receiving surface, and the supporting platform is configured to receive the further edge portion of the stack;
a downholder element arranged for adjusting a size of a gap between the downholder element and the supporting platform, such that the further edge portion of the stack is clampable between the downholder element and the supporting platform;
the transport device is configured to move along a first direction between the receiving position, at which the stack is received by the delivery ramp, and a hand over position at the processing device, such that the stack is movable from the receiving position to the hand over position; and
the first direction is transverse to the delivery ramp, parallel to an edge of the delivery ramp, and parallel to the further edge portion of the stack which is locatable on the delivery ramp.

US Pat. No. 10,167,149

BANKNOTE SEPARATION APPARATUS AND METHOD FOR BANKNOTE BUNDLE RECEIVING MACHINE

HYOSUNG TNS INC., Seoul ...

1. A banknote separation apparatus for a banknote bundle receiving machine, comprising:a guide unit provided on a route along which a banknote bundle inputted into the banknote bundle receiving machine is moved;
a pickup roller unit provided above the guide unit in a spaced-apart relationship with the guide unit and configured to separate a banknote from the banknote bundle and to feed the banknote;
a pickup roller raising/lowering unit configured to raise or lower the pickup roller unit;
a feeding roller unit provided on a back side of the pickup roller unit;
a gate roller unit provided under the feeding roller unit and configured to maintain a predetermined distance from the feeding roller unit, and
an elastic member configured to apply a downward biasing force to the pickup roller unit and to make sure that the pickup roller unit comes into contact with the banknote.

US Pat. No. 10,167,148

IMAGE FORMING APPARATUS AND DUSTPROOF COVER

Ricoh Company, Ltd., Tok...

1. An image forming apparatus, comprising:an image forming unit which forms an image on paper being conveyed on a paper conveyance path provided in a device main body;
a paper loading base on which manual-feed paper is loaded, the paper loading base having a lower end rotatably supported on at least one outer surface portion of the device main body, the paper loading base configured to be opened from an upper end thereof, and the paper loading base configured to be disposed at a desired oblique angle or in an overhang state;
a manual-feed paper conveying unit which is disposed in a position corresponding to the paper loading base in the device main body and configured to convey the manual-feed paper loaded on the paper loading base onto the paper conveyance path one by one;
a dustproof cover which entirely covers paper stored in the paper loading base when the paper loading base is in the overhang state, the dustproof cover including,
a base which engages with the paper loading base, and
an opening-and-closing cover which is rotatably connected to the base and is opened upwardly, wherein the base includes,
a pair of base-side lateral surface parts detachably engaging with a pair of lateral portions of the paper loading base in a direction of a rotation axis of the paper loading base in the overhang state, and
a base-side upper surface part of which both ends integrally connect the pair of base-side lateral surface parts;
first protrusions provided on both lateral portions of an upper surface of the paper loading base at desired positions corresponding to the base; and
second protrusions respectively corresponding to the first protrusions and provided on respective lower end surfaces of the pair of base-side lateral surface parts at positions closer to the device main body than the first protrusions, wherein
the second protrusions are provided to be in contact with the first protrusions when the dustproof cover moves in an overhang direction without being lifted.

US Pat. No. 10,167,147

SHEET FEEDER DEVICE AND IMAGE FORMING APPARATUS

KONICA MINOLTA, INC., To...

1. A sheet feeder device that stores and sends out a transfer medium, comprising:a sheet feeder device main unit having an opening formed at an upper portion, the sheet feeder device main unit including an upstream partial lid located on an upstream side in a conveying direction and a downstream partial lid located on a downstream side in the conveying direction, the upstream partial lid and the downstream partial lid covering at least part of the opening;
a sheet feed tray provided in the sheet feeder device main unit, the transfer medium being loaded onto the sheet feed tray;
an elevating unit configured to lift up and down the sheet feed tray; and
a control unit configured to control the lifting up and down of the sheet feed tray,
wherein the control unit senses opening and closing of the upstream partial lid and the downstream partial lid, and controls the lifting up and down being performed by the elevating unit in accordance with a result of the sensing;
wherein the result of the sensing further includes existence/nonexistence of a transfer medium loaded onto the upstream partial lid.

US Pat. No. 10,167,146

CONTAINERIZED TRANSPORTATION TRAILERS

Amazon Technologies, Inc....

1. A system, comprising:a shipping container, comprising:
a first side and a second side;
a plurality of compartments positioned longitudinally along the shipping container, the plurality of compartments being defined by a plurality of openings between the first side and the second side of the shipping container;
a plurality of modules positioned in the plurality of compartments, individual ones of the plurality of compartments being configured to receive the plurality of modules at an interior of the shipping container such that a first side of the plurality of modules is exposed on the first side of the shipping container during transport, and a second side of the plurality of modules is exposed on the second side of the shipping container during transport;
a sensor;
processing circuitry coupled to the sensor comprising at least one hardware processor that, through execution of program instructions, is configured to:
detect a placement of one of the plurality of modules in one of the plurality of compartment using the sensor;
in response to the placement of the one of the plurality of modules in the one of the plurality of compartments, determine that the one of the plurality of modules requires a resource based at least in part on data corresponding to the one of the plurality of modules; and
provide the resource to the one of the plurality of modules;
wherein individual ones of the plurality of modules are independently insertable into or removable from a corresponding one of the plurality of compartments of the shipping container, and
wherein the first side and the second side of the individual ones of the plurality of modules comprise at least one portal configured to receive at least one projection to insert or remove a corresponding one of the plurality of modules into or from a corresponding one of the plurality of compartments from either the first side or the second side of the shipping container.

US Pat. No. 10,167,145

PICK OR PUT STATION WITH CONTROLLABLE RECEPTACLE EXCHANGE

Dematic Corp., Grand Rap...

1. A receptacle exchange that is adapted to supply and retrieve a receptacle with respect to a process location at which an operator processes the receptacle by picking articles from or putting articles to a receptacle, said receptacle exchange comprising:a lift that is adapted to elevate a receptacle from a supply location to the process location;
an extractor that is adapted to retrieve a receptacle from the process location to an extracted location;
a first drive that moves said lift between the supply location and the process location and that moves said extractor between the process location and the extracted location;
a second drive that moves an inclination of said extractor; and
a control, said control controlling said first and second drives, wherein said control is adapted to separately set a contour of an insertion inclination profile of said extractor as it moves between the extracted location and the process location and the contour of a retraction inclination profile of said extractor as it moves between the process location and the extracted location.

US Pat. No. 10,167,144

DEVICE FOR REPOSITIONING TUBES IN A TUBE RACK

Roche Diagnostics Operati...

1. A device for repositioning tubes in a tube rack, the device comprising:a stationary base;
a mount movable relative to the base in a first moving direction towards a tube rack and a second moving direction opposite to the first direction;
at least one actuator for moving the mount;
one or more grippers coupled to the mount and movable with the mount, each gripper comprising a pair of gripping arms provided with gripping portions for gripping a tube, wherein each gripper gripping a tube can slide along the tube in case the tube is fully inserted in a holding seat of the tube rack;
at least one biasing element resiliently coupled to the mount and to the gripping arms in a manner to be movable relative to the mount and thereby move the gripping portions towards or away from each other; and
at least one blocking element resiliently coupled to the stationary base configured to engage with the biasing element and to block movement of the biasing element with respect to the mount against a resilient force during a first period in which the mount is moved along a travel path in the first moving direction so as to move the gripping portions towards each other and configured to disengage from the biasing element while moving in the first direction after the mount has been moved along the travel path and before a second period in which the mount is moved in the second moving direction so as to allow the gripping portions to be resiliently moved away from each other, wherein the blocking element is a lever pivotably fixed to the base and configured such that the biasing element is or gets in contact with the lever during the first period and subsequently slides off the lever before the second period.

US Pat. No. 10,167,143

DEVICE AND METHOD FOR MOVING TRANSPORT ELEMENTS IN A CONTAINER TREATMENT SYSTEM

KRONES AG, Neutraubling ...

1. A method for adapting motion profiles of a plurality of individually controllable transport elements for transporting containers in a container treatment system along a transport path, wherein the plurality of transport elements are movably arranged on the transport path, comprising:determining a treatment state of at least one container carried along by a first transport element among the plurality of transport elements,
wherein the first transport element is moved by means of at least one of an open- or closed-loop control unit of the container treatment system as part of a stream of transport elements,
wherein a motion profile of the first transport element is adapted by means of the open- or closed-loop control unit in response to the determined treatment state, the motion profile being one of the motion profiles of the plurality of individually controllable transport elements,
wherein determining the treatment state of the container carried along by the first transport element comprises comparing the determined treatment state with a predetermined desired treatment state, and
wherein the motion profile of the first transport element in case of a deviation of the determined treatment state from the predetermined desired treatment state is adapted such that a distance of the first transport element from a second transport element directly preceding the first transport element in the stream is reduced to a predetermined distance.

US Pat. No. 10,167,142

ARTICLE TRANSPORT FACILITY

Daifuku Co., Ltd., Osaka...

1. An article transport facility comprising:a plurality of ceiling guided vehicles that travel along a traveling rail provided on a ceiling side, wherein each of the ceiling guided vehicle includes:
a holding portion that holds an article to be transported;
a body portion that supports the holding portion such that the holding portion can be moved up and down;
a power-driven travel driving portion that drives the ceiling guided vehicle to travel;
a power-driven elevation driving portion that drives the holding portion to move up and down; and
a control portion that outputs a control signal and controls operation of the travel driving portion and the elevation driving portion;
an auxiliary unit that supplies, to the ceiling guided vehicle, one or both of power for driving the travel driving portion and the elevation driving portion and the control signal, the auxiliary unit provided so as to be attachable to and removable from the ceiling guided vehicle, the auxiliary unit including a supported portion configured to be supported in a suspended state on a supporting portion provided on the ceiling guided vehicle; and
an abutment portion configured to abut against the ceiling guided vehicle in a plurality of abutment areas disposed at different positions in plan view,
wherein the abutment portion includes a pair of abutting parts,
wherein each of the pair of abutting parts is configured to be switchable between a hold orientation in which the abutting part is caused to abut against the corresponding abutment area, and a hold-release orientation in which the abutting part is moved away from the abutment area, and
wherein the abutment areas are provided at positions lower than the supporting portion in a vertical direction.

US Pat. No. 10,167,141

DEVICE FOR TRANSPORTING MOULDS FOR CHOCOLATE OR CONFECTIONERY

HACOS, NAAMLOZE VENNOOTSC...

1. Device for transporting moulds for chocolate or confectionery, comprising:at least two rods that extend in parallel to one another below, above or next to the moulds;
each of said at least two rods being movable back and forth along its respective longitudinal direction and being provided with a number of catches for the moulds that are distributed along its respective longitudinal direction;
wherein said catches of one of said at least two rods are positioned transversely relative to said catches of the other of said at least two rods;
each of said at least two rods being rotatable about its respective longitudinal direction so that its respective catches can rotate from a first position in which they can convey the moulds, to a second position in which they are situated below or above or in a non-conveying position next to the moulds.

US Pat. No. 10,167,140

DEVICE AND METHOD FOR TRANSPORTING ELONGATED METAL MATERIAL

Muhr und Bender KG, Atte...

1. A device for transporting elongated metal material, comprising:a controllable first chain drive unit including a continuous first chain;
a controllable second chain drive unit including a continuous second chain;
wherein the first and the second chain drive unit are arranged such that the elongated material is passed between the first and the second chain with frictional contact so that, by operating the first and the second chain drive units, the elongated material is moved in a direction of movement of chain portions contacting the elongated material;
a controllable first pressure unit configured to apply a first pressure force to the first chain towards the elongated material;
a controllable second pressure unit configured to apply a second pressure force to the second chain towards the elongated material; and
at least one controllable adjusting unit mechanically connected to at least one of the first and second chain drive units and configured to move the at least one of the drive units in a longitudinal direction of the elongated material during operation;
wherein the first chain drive unit, the first pressure unit and the at least one adjusting unit can be controlled independently from one another, so that the speed of feed of the elongated material is adjustable independently of the pressure force of the first pressure unit.

US Pat. No. 10,167,139

SELF-VENTING TRASHCAN SYSTEM

Source Unlimited LLC, Le...

1. A self-venting trashcan system for use with a trashcan having interior smooth sides and a bottom interior surface, comprising:a) a rigid strip having a strip height shorter than a height of said side of said trashcan, said rigid strip having left and right sides including a top and a bottom edge with a thin web extending from the top edge to the bottom edge of each left and right side to facilitate bending, both left and right sides having pressure sensitive double sided tape appointed to be attached to the interior smooth sides of said trashcan to form a first air entry/exit pathway;
b) a height setting spacer object appointed to set the smooth rigid strip off the bottom interior surface of the trashcan to ensure a gap between an end of the rigid strip and the bottom interior surface of said trashcan to thereby provide a second air entrance/exit pathway between the end of said rigid strip and the bottom interior surface of said trashcan; and
c) said second air entrance/exit pathway allowing trapped air accumulated between a trashcan liner and said trashcan interior surface during placement of the trashcan liner within the trashcan interior to exit through said first air exit pathway,
whereby removal of said trash filled trashcan liner for disposal is carried out without vacuum pull back, minimizing the removal effort and tearing of said trashcan liner, and the trashcan liner is readily placed within smooth sidewalls of a trashcan and, when full, removed with reduced effort due to the release of vacuum created between the trashcan liner and the trashcan's smooth interior walls by entry of air through said second air entrance/exit pathway below said rigid strip.

US Pat. No. 10,167,138

METHOD FOR DELIVERY OF PROPPANT TO A FRAC SITE

Can Do Logistics LLC, Be...

1. A method for delivering a proppant to a site of a well being fraced, the method including the following steps:modifying a standard cargo container into a modified cargo container by inserting a hopper module through a side door of said standard cargo container, wherein a base of the hopper module defines an area substantially equal to a bottom inside surface of said standard cargo container, wherein a cargo area of said modified cargo container is defined by inner surfaces of both said modified cargo container and said hopper module;
sliding a top hatch of said modified cargo container in a first horizontal direction from a closed position to an opened position, wherein the top hatch is aligned with a top opening;
loading a proppant into said modified cargo container through said top hatch thereon into the cargo area located inside said modified cargo container;
sliding said top hatch of said modified cargo container in a second horizontal direction from said opened position to said closed position;
transporting said modified cargo container with said proppant therein to said site;
lifting said modified cargo container with said proppant therein above a bulk sand container with a rough terrain container handler, said lifting performed from above via at least four points of contact between said modified cargo container and said rough terrain container handler;
opening a bottom hatch of the lifted modified cargo container to empty said proppant into said bulk sand container, said opening step performed by sliding said bottom hatch of said modified cargo container in a first horizontal direction from a closed position to an opened position wherein the bottom hatch is aligned with a bottom opening;
sliding said bottom hatch of said modified cargo containers in a second horizontal direction from said opened position to said closed position, wherein a user utilizes at least one control panel to effectuate sliding of the top hatch and the bottom hatch;
setting the empty modified cargo container aside with said rough terrain container handler; and repeating said lifting, opening, sliding and setting aside steps with other full modified cargo containers with said rough terrain container handler.

US Pat. No. 10,167,137

FLAME RESISTANT VISCOSE FILTER APPARATUS AND METHOD

EFIP Holdings LP, Dunedi...

1. A kitchen vent hood filter assembly, the filter assembly comprising:a filter pad comprising oleophilic fibers and viscose fibers, wherein:
the filter pad is formed through at least one of thermo-bonding, air-laid, and spunbond;
approximately 25% of the viscose fibers have a linear density between between 8-9 denier;
approximately 25% of the viscose fibers have a linear density of approximately 2 denier;
the viscose fibers comprise approximately 50% of the fibers of the filter pad; and
the oleophilic fibers comprise approximately 50% of the fibers of the filter pad;
a bonding emulsion; and
a structural support providing support to the filter pad to maintain the filter pad in a generally flat configuration and to allow installation of the filter pad within a ventilation hood.

US Pat. No. 10,167,135

SINGLE-PORTION PACKAGE, SYSTEM AND PROCESS FOR PREPARING LIQUID PRODUCTS BASED UPON SAID SINGLE-PORTION PACKAGES

MITACA S.r.l., Robecchet...

1. A single-portion package for preparing a liquid product, comprising:a top wall, a side wall and a base wall together defining an internal volume within which there is disposed a flow distribution element in the form of a disc-like circumferential element with a plurality of spaced flow passageways so as to divide said internal volume into a first free space next to said top wall for receiving a fluid to be distributed by means of said flow distribution element, and a second compartment space for storing at least one substance to be extracted by means of said fluid flowing through and being distributed by said flow distribution element,
wherein an outer peripheral portion of said flow distribution element is, depending on a defined liquid pressure acting in said first space upon said flow distribution element, movably retained in different positions with reference to and along said sidewall;
wherein said peripheral portion of said flow distribution element is adapted so as to be movably retained at least in a region of said sidewall including a first distance relative to the base wall, and also including a smaller distance relative to the base wall by means of a pressure-fit interaction, at least liquid tight, between at least part of said peripheral portion and the side wall, said flow distribution element being initially disposed at a first position at said first distance thereby confining without compressing said substance in said second space;
wherein said distribution element (4) is provided in a material of regular thickness in the central portion thereof; and
wherein said peripheral portion is provided with a side engagement portion configured to form a shoulder-like projection extending along at least part of the outer extension of the flow distribution element and with an increased thickness along at least part of its extension relative to the rest of said peripheral portion, for interacting in a movable pressure-fit manner with said sidewall at least in the region including said distances relative to the base wall.

US Pat. No. 10,167,133

SHAKER WITH AN OUTER CONTAINER AND WITH AN INNER CONTAINER MOVABLE THEREIN

KEEEPER GmbH, Stemwede (...

1. A shaker (2) comprising:an outer container (4) comprising an outer container side wall (8) and a floor with a dispensing opening (30);
a sieve (34) disposed in the dispensing opening (30);
an inner container (6) disposed in an interior of the outer container (4) so as to be movable therein and comprising an inner container side wall (10);
the inner container (6) comprising a storage space (36) for a granular or powdery material;
the outer container side wall (8) comprising an opening (12) through which a first portion of the inner container side wall (10) can be grasped when the outer container (4) is gripped;
a space (22) formed in the interior of the outer container (4) between a second portion of the inner container side wall (10) and the outer container side wall (8);
at least one energy accumulator (24) arranged in the space (22);
the inner container (6), in a rest position, pressed with the first portion of the inner container side wall (10) against the opening (12) in the outer container side wall (8) by the at least one energy accumulator (24) such that the inner container side wall (10) covers the opening (12) of the outer container side wall (8) relative to the interior of the outer container (4);
the inner container (6) movable, counter to a force of the at least one energy accumulator (24), in a direction of movement transversely relative to a longitudinal axis (14) of the outer container (4) into a displacement position;
the inner container (6) comprising a discharge opening (32) which, when moved by a displacement movement of the inner container (6) from the rest position to a displacement position, is moved across the sieve (34) disposed in the dispensing opening (30).

US Pat. No. 10,167,132

ELEVATING LIFT DISPENSER AND CONTAINER

1. A container comprising:a canister defining a canister interior cavity, the canister having at least one interior sidewall and a canister top opening defined by a canister upper lip and a canister opening diameter, and wherein the canister includes at least one engagement feature that comprises a groove formed in the canister interior sidewall that is either a substantially helical groove or a substantially longitudinal groove;
a lift having one or more lift projections extending therefrom, the lift structured to hold contents and be movable vertically with the container; and
an operator comprising an operator main body portion which defines an operator interior cavity and an operator main body portion outside diameter, the operator having a gripping ring disposed at a first end of the operator and further structured to be gripped to rotate the operator within the canister to move the lift vertically, wherein the operator includes at least one operator engagement feature that comprises a slot formed though the operator main body portion, wherein the at least one operator feature comprises a substantially helical slot when the at least one canister engagement feature comprises a substantially longitudinal groove and wherein the at least one operator feature comprises a substantially longitudinal slot when the at least one canister engagement feature comprises a substantially helical groove;
wherein the lift is received in the operator interior cavity and the operator main body portion is received within the canister interior cavity such that each of the one or more lift projections extend through a respective operator engagement feature into a respective canister engagement feature to allow the lift to move vertically within the container;
wherein the canister inside diameter and the operator main body portion outside diameter are selected such that the operator main body portion when received within the canister interior cavity is close enough to the interior sidewall of the canister to enable each of the one or more lift projections to extend through the respective operator engagement feature into the respective canister engagement feature; and
wherein rotation of the operator relative to the operator relative to the canister causes the one or more lift projections to travel along the respective canister engagement features and the respective operator engagement features to thereby move the lift in a vertical direction within the operator main body portion.

US Pat. No. 10,167,131

CONTENT DISPENSING CONTAINER APPARATUS

1. A container for dispensing contents, the container comprising:a first container portion comprising: an opening to access the contents, a first container portion top, a first container portion bottom, a first container portion inner surface, and a first container portion outer surface;
a second container portion to contain at least a portion of the contents, the second container portion comprising: a second container portion top, a second container portion bottom, a second container portion inner surface, a second container portion outer surface, and a cam surface;
a tab extending inwardly from the first container portion inner surface and engaging the second container portion; and
a rotating cam portion, rotatably engaged with the cam surface, the rotating cam portion comprising a grasp ring;
the second container portion encompassed by the first container portion and forming an internal chamber within the first container portion; and
the second container portion movable relative to the first container portion between the first container portion bottom and the first container portion top to elevate at least some of the contents contained within the second container portion;
wherein as the second container portion is elevated from the first container portion bottom toward the first container portion top, the tab engages the second container portion bottom, preventing the second container portion from moving downward beyond the tab toward the first container portion bottom.

US Pat. No. 10,167,130

INSULATING CONTAINER

STRATEGIC SOLUTIONS INTER...

1. An insulating container, comprising:a vessel and a wrap;
said vessel having a wall, said wall having one or more protrusions on one side of said wall that are matched to one or more corresponding recesses on the opposite side of said wall, wherein said protrusions have a substantially consistent wall thickness, and
said wrap cooperates with said protrusions thereby defining one or more void spaces between said wall and said wrap, said void spaces having a depth between about 5 mm and about 12 mm, thereby providing insulating properties to said container.

US Pat. No. 10,167,129

FOOD TRAY WITH IMPROVED CONSTRUCTION

Packaging 2.0 Inc., Prov...

1. A tray construction, comprising:a tray having a bottom wall located at a lower end of thereof, the bottom wall having a peripheral edge;
a plurality of side walls extending upwardly from the bottom wall and located at the peripheral edge of the bottom wall, each side wall having a lower edge connected to the bottom wall, each side wall having an upper edge at an upper end of the tray;
a rim located at the upper end of the tray, the rim connected to the upper edge of the side walls at a peripheral rim edge, the rim extending outwardly from the upper edge of each respective side wall;
a skirt depending downwardly from the rim adjacent to an outer peripheral rim edge, the skirt having a lower edge and being spaced outwardly from the side walls; the skirt being movable between a first resting position and a second flexed position;
a flexible wrap film residing about the upper edge and upper end of the tray extending downward towards, and over, the peripheral rim edge to the bottom of the tray, the film moving the skirt from the first resting position to the second flexed position; the film being controllably positioned, when the skirt is in the flexed position, to avoid tearing thereof, and
a plurality of ribs defined in at least one of: the side walls and the bottom wall; the plurality of ribs support the film at the transition from the peripheral rim edge to the bottom of the tray to avoid tearing thereof,
wherein the peripheral rim edge of the tray includes a stepped wall defining a groove, the stepped wall being oriented and extending horizontally, and
wherein the skirt includes an uppermost edge, the upper most edge of the skirt extends downward from the stepped wall.

US Pat. No. 10,167,128

INFLATOR DEVICE AND METHOD FOR INFLATABLE PACKAGING

Airguard Ltd., Ein HaMif...

1. An inflation device for pressurized inflation of an un- inflated package, the package comprising two layers, said layers being generally flat prior to inflation, and an inflation opening of a size up to a predetermined maximum size in said package, the inflation device comprising:an inflation tool, for contacting the package at the inflation opening to inflate the package through the inflation opening using inflation fluid from a pressure source, the inflation tool having an enclosing surface to enclose said inflation opening, said enclosing being external to said package, said enclosing surface covering an area which is larger by a finite amount than said predetermined maximum size; and
an outer wall, the outer wall defining a region surrounding said inflation tool and delineated by said inflation tool and said outer wall, said region being connected to a vacuum source, wherein said inflation tool comprises an inwardly turning lip and said outer wall comprises an outwardly turning lip, both of said inner wall and said outer wall forming ‘w’ shapes.

US Pat. No. 10,167,127

CYLINDRICAL BOTTLE WITH BOTTOM

YOSHINO KOGYOSHO CO., LTD...

1. A bottle formed of a synthetic resin material and having a bottomed cylindrical shape, the bottle comprising:a bottom wall portion of a bottom portion, the bottom wall portion including:
a grounding portion that is located at an outer circumferential edge of the bottle,
a rising circumferential wall portion that is continuous with the grounding portion on a radially inner side of the grounding portion and that extends upward, and
a movable wall portion that protrudes from an upper end of the rising circumferential wall portion on a radially inner side of the rising circumferential wall portion,
wherein:
a connected portion connects the rising circumferential wall portion with the movable wall portion,
the movable wall portion is movable upward around the connected portion,
a plurality of ribs are radially disposed around a bottle axis on the movable wall portion,
the ribs include a plurality of main recesses, which are each recessed upward, and a connection recess,
the main recesses of the plurality of main recesses are arranged at predetermined intervals in a radial direction of the bottle,
the connection recess connects adjacent main recesses of the plurality of main recesses that are adjacent to each other in the radial direction of the bottle,
a bottom surface of the connection recess is convex toward a bottom side of the bottle, and
a depth ratio D2/D1 is greater than 2/9 and less than 1 such that D2 is a depth of the connection recess and D1 is a depth of each main recess of the plurality of recesses.

US Pat. No. 10,167,126

BOX WITH INNER BAG FOR LIQUID FOOD

INVINEO S.A., Thon (BE)

1. A rigid box having at least one wall (2) defining an inner chamber (3) in which a flexible bag (4) extends, which flexible bag (4) is designed to contain a liquid or viscous food to be consumed in an appropriate serving temperature range by using an aqueous medium flowing within the inner chamber (3), said flexible bag (4) being selected from the group consisting of a flexible bag (4) associated with a part (5) comprising a valve, a flexible bag (4) associated with a part (5) comprising a membrane, and a flexible bag (4) associable with a protection means (6) designed to cooperate with a part (7) comprising a valve; wherein said rigid box (1) having a lower part (1I) with a bottom (8), an upper part (1S) and at least one passage (9) for the part (5);in which the flexible bag (4) defines within the inner chamber (3) the part located outside said flexible bag (4);
in which the box is at least associated with a means for protecting the at least one wall (2) against the liquid aqueous medium flowing within the inner chamber (3) outside the flexible bag (3);
in which the rigid box (1) is provided or associated, in the vicinity of the lower part (1I), with an element (8A) having at least one passage (10) designed to form a connection between the part of the inner chamber (3) located outside said bag (4) and a pipe (11),
in which the rigid box (1) is provided or associated at its upper part (1S) with a plate (18) having the at least one first passage (9) designed to cooperate with the part (5,7) associated or associable with said flexible bag (4) and a second passage (610) towards the part of the inner chamber (3) outside the flexible bag (4), and
in which at least a portion of the at least one side wall (2) of the rigid box (1) located between the lower part (1I) and the upper part (1S) cooperates with a means for forming one or more guide channels (12) between flexible the bag (4) and the said portion of the at least one side wall (2), said one or more guide channels (12) remaining open for passage of the aqueous medium between the passage of the lower part and the second passage of the plate (18) even in the presence of the flexible bag (4) in the inner chamber (3).

US Pat. No. 10,167,125

ARRAY OF BREAKABLE WAX MELTS AND ARRAY OF CONTAINERS FOR BREAKABLE WAX MELTS

1. An array of breakable wax melts comprising:a first breakable wax melt disposed in a first container and having a first shape that corresponds with a first theme;
a second breakable wax melt disposed in a second container that is separate from the first container and having a second shape that is different from the first shape, wherein the second shape corresponds to a second theme,
wherein the first and second themes are each selected from the group consisting of: a perfume mixture, holiday, season, a graphic on a container for containing the first or second breakable wax melts, and combinations thereof,
wherein the first and second breakable wax melts comprise different perfume mixtures that correspond with the first and second themes, and
wherein the first and second breakable wax melts each comprise at least two shaped portions that are joined together along at least one frangible connecting portion, wherein the first and second breakable wax melts are breakable about the frangible connecting portion,
wherein the shaped portions of the first breakable wax melt have a different shape than the first shape of the first breakable wax melt, and wherein the shaped portions of the second breakable wax melt have a different shape than the second shape of the second breakable wax melt.

US Pat. No. 10,167,123

NON-REMOVABLE TAMPER RESISTANT LID

1. A tamper resistant lid comprising:a centre axis;
an outer member;
an inner member;
the outer member and the inner member each comprise an outer surface, an inner surface, a circular base having a circular wall extending around a periphery of the circular base wherein a distal surface of a distal end of the inner member comprises a first tilting surface inclined in a distal direction from the inner surface toward the outer surface of the inner member, and the outer member comprises a second tilting surface arranged on a proximal surface of a circumferential lock flange at a distal end of the outer member, the second tilting surface inclined in a proximal direction toward the centre axis of the tamper resistant lid, the first tilting surface and the second tilting surface providing a hook like lock configuration of the inner member with respect to the outer member; and
the outer member comprises at least one stop member, the at least one stop member having a third tilting surface.

US Pat. No. 10,167,122

NON-REMOVABLE TAMPER RESISTANT LID

1. A method for sealing a container comprising:providing a tamper resistant lid comprising a centre axis; an outer member; an inner member; the outer member and the inner member each comprise an outer surface and an inner surface wherein at least a part of the outer surface of the inner member is adjacent at least a part of the inner surface of the outer member, the inner member having a thread; and at least one stop member preventing the inner member from rotation with respect to the outer member,
placing the tamper resistant lid onto a container;
rotating the outer member in a first direction to allow the thread of the inner member to connect to a thread of a neck element of the container; and
disabling the at least one stop member by rupturing the at least one stop member by applying a designated force after the inner member has been connected to the container, so that the outer member can be freely rotated with respect to the inner member to thereby prevent removal of the tamper resistant lid from the container.

US Pat. No. 10,167,121

CONTAINER CLOSURE

Michael Murray, London (...

1. A container having an opening and a closure movable between a first position in which the opening is closed and a second position in which the opening is exposed, the closure comprising a closure flap located within the container and a pivot arm, the pivot arm having a first end secured to the closure flap and a second end having a weighted portion, the pivot arm being pivotally mounted within the container at a pivot point located between the first and second ends, wherein when the container is in a first position, the weighted portion acts to bias the closure flap to close the opening and when the container is rotated in a first direction to a second position, the weighted portion causes the pivot arm and the closure flap to rotate relative to the container in a second direction opposite to the first direction, thereby to bias the closure flap into the container and away from the opening in order to expose the opening.

US Pat. No. 10,167,120

TRAVEL BOTTLE WITH TWISTING LOCKING LID

Navajo Manufacturing Comp...

1. A cap of a dispensing bottle, said cap comprisinga main body,
a valve body pivotably mounted on the main body, and
a twisting ring body rotatably mounted on the main body, said twisting ring body mounting said valve body in a fixed position on said main body in a locked position of said twisting ring body and said twisting ring body allowing said valve body to be pivoted on said main body in an unlocked position of said twisting ring body.

US Pat. No. 10,167,119

SPOUT FOR LID

Helen of Troy Limited, S...

1. A spout for a lid, where the lid is constructed and arranged to fit over and close an open top of a container, the spout comprising:an elongated fluid conduit having an upper outside end to be located in a user's mouth and an opposite lower inside end and lying along a conduit longitudinal axis, the conduit having a pair of opposed convex curved sidewalls that meet at two opposed locations at an angle of less than 180 degrees to define a generally elliptical cross-sectional shape that has a major axis that passes through the sidewall meeting locations and a minor axis that is orthogonal to the major axis;
a bite valve comprising a membrane located within the conduit and spaced from the ends of the conduit, the membrane coupled to both sidewalls so as to fully block the conduit, and a slit through the membrane, where the slit lies along a slit axis that is transverse to the major axis of the generally elliptical cross-sectional shape, and the slit is co-linear with the minor axis, or lies in a vertical plane that includes the minor axis of the generally elliptical cross-sectional shape; and
two wall-strengthening ribs located at each end of the slit along the slit axis, one projecting inwardly from each of the sidewalls and coupled to the top of the membrane, wherein the ribs are centered on the ends of the slit, and each rib extends in the direction of the conduit longitudinal axis a majority of the length from the top of the membrane to the outside end of the conduit.

US Pat. No. 10,167,118

CLOSURE CAP WITH A FLANGE UPPER SURFACE HAVING AN INTERRUPTED ANNULAR RECESS

Plastek Industries, Inc.,...

1. A container comprising:a body having a neck extending to a mouth defining a body opening;
a spout fitment having:
a spout within the body opening; and
an outer wall within the neck; and
a cap having:
an upper sidewall;
a flange protruding radially from the sidewall, an underside of the flange contacting the mouth; and
an outer sidewall depending from the flange, an internal thread of the cap outer sidewall engaged to an external thread of the neck wall,wherein:the flange has an upper surface having an interrupted annular recess.

US Pat. No. 10,167,117

LID

RICH CUP BIO-CHEMICAL TEC...

1. A lid, utilized for covering a cup, the lid comprising:a top portion;
an annular side plate, extending downwardly from a periphery of the top portion, an axial direction and a radial direction perpendicular to the axial direction being defined by the side plate, the side plate being formed with at least a hole;
at least an engagement portion, disposed on the side plate, the engagement portion comprising an engagement plate, the engagement plate having a bottom edge and a top edge, the bottom edge extending from and being connected to the side plate, the engagement plate extending from the bottom edge upwardly along the hole so that the engagement plate is received in the hole, the engagement plate and the side plate being located at a same plane, the engagement plate being bendable, an engagement space being defined in middle of the top portion, the side plate, and the top edge of the engagement plate when the engagement plate is bent inwardly along the radial direction;
wherein a thickness of the side plate is larger than a thickness of the engagement plate, the engagement plate is deformable;wherein the side plate and the engagement plate as a whole are flattened, the engagement plate is pivotable around the bottom edge with respect to the side plate between a first position and a second position, the engagement plate and the side plate are located at the same plane when the engagement plate is located at the first position, the engagement plate is bent inward to clutch on a rim flange of the cup when the engagement plate is located at the second position, the engagement plate tends to retain at the first position, the engagement plate is for being pressed inwardly to the second position after putting the lid on the cup to clutch on the rim flange of the cup;wherein the side plate has at least an extension portion protruding downwardly from where the bottom edge of the engagement plate extends, a distance from a top surface of the side plate to a bottom edge of the extension portion along a direction is over two times of a dimension of the rim flange of the cup along the direction;
wherein the engagement plate is formed with a notch recessed downwardly from a middle portion of the top edge of the engagement plate;
wherein the engagement portion has a width along the axial direction larger than a width of the annular side plate along the axial direction.

US Pat. No. 10,167,116

FLEXIBLE BAG WITH MICROCAPILLARY STRIP

Dow Global Technologies L...

1. A flexible bag comprising:opposing flexible films composed of a polymeric material, the flexible films defining a common peripheral edge;
a microcapillary strip located between the opposing flexible films and extending along a portion of the common peripheral edge, the microcapillary strip comprising two or more channels disposed in a matrix, the channels extending parallel with respect to each other from a first end to an opposing second end of the microcapillary strip, each channel having a diameter from 50 ?m to 1,000 ?m, the microcapillary strip having a length extending from the first end to the opposing second end from 0.1 cm to 10.0 cm;
a peripheral seal extending along at least a portion of the common peripheral edge, the peripheral seal sealing the microcapillary strip between the opposing flexible films;
the peripheral seal forming a closed compartment; and
an amount of a flowable solid particulate material (FSPM) in the closed compartment.

US Pat. No. 10,167,115

SEALABLE CONTAINER ASSEMBLY WITH INTERNAL, REMOVABLE PANEL AND SPOUT

Buddeez, Inc., Wentzvill...

1. A container assembly comprising:a container having an interior volume and a top opening providing access into the interior volume;
a panel with a spout, the panel being supported by the container in the interior volume of the container for movement of the panel horizontally between a first position of the panel in the interior volume where the panel is secured to the container against vertical movement of the panel relative to the container and a second position of the panel in the interior volume where the panel is unsecured from the container for vertical movement of the panel relative to the container out of the interior volume of the container; and,
a lid removably attachable to the container over the top opening of the container with the panel supported by the container in the interior volume of the container.

US Pat. No. 10,167,114

CONFIGURABLE CONTAINER-SUPPORT FRAME

Tigerback Enterprises, LL...

1. A configurable container-support frame comprising:(a) a first frame section comprising:
(i) at least three telescoping members, wherein each telescoping member is substantially parallel to each other telescoping member, and
(ii) at least three cross members, wherein each cross member connects to two different telescoping members and wherein each cross member is substantially perpendicular to each telescoping member to which it connects;
(b) a second frame section comprising:
(i) at least three telescoping members, wherein each telescoping member is substantially parallel to each other telescoping member, and
(ii) at least three cross members, wherein each cross member connects to two different telescoping members and wherein each cross member is substantially perpendicular to each telescoping member to which it connects,
(iii) wherein each telescoping member of the second frame section is nested with a telescoping member of the first frame section thereby forming pairs of nested telescoping members;
(c) at least three detents, each detent comprising a pin and a spring, wherein each detent is disposed within a different telescoping member such that each of the pairs of nested telescoping members includes at least one detent and wherein each detent is configured to selectively engage one of the pairs of telescoping members thereby locking the relative positions of the telescoping members of the pair of telescoping members; and
(d) a detent-release mechanism comprising:
(i) a single trigger, and
(ii) at least three detent-actuators, wherein each detent-actuator is disposed such that each pair of nested telescoping members includes at least one detent-actuator and wherein each detent-actuator is configured to selectively engage a detent, and
(iii) at least three force-transfer elements, wherein each force-transfer element is disposed to effect mechanical communication between the trigger and at least one of the three detent-actuators such that if a force is applied to the trigger the force will be communicated to each detent-actuator.

US Pat. No. 10,167,113

METHOD OF STACKING OVERPACK SALVAGE DRUMS

ENPAC L.L.C., Eastlake, ...

1. A method of stacking a plurality of overpack salvage drums including a first overpack salvage drum and a second overpack salvage drum, the first overpack salvage drum including,a first drum body including a bottom wall, a side wall, and an open top, the bottom wall and side wall cooperating to define an interior volume of the first drum body; and
a first lid configured to close the open top of the first drum body, the first lid including a plurality of castellations that extend upwardly from a top side of the first lid, the plurality of castellations being arranged circumferentially at a periphery of the top side of the first lid and being separated from each other by gaps, wherein when the top side of the first lid is viewed in plan, the gaps separating the plurality of castellations have a larger circumferential dimension than the plurality of castellations;the second overpack salvage drum including,a second drum body including a bottom wall, a side wall, and an open top, the bottom wall and side wall cooperating to define an interior volume of the second drum body; and
a second lid configured to close the open top of the second drum body, the second lid including a plurality of castellations that extend upwardly from a top side of the second lid, the plurality of castellations arranged circumferentially at a periphery of the top side of the second lid and separated from each other by gaps, wherein when the top side of the second lid is viewed in plan, the gaps separating the plurality of castellations have a larger circumferential dimension than the plurality of castellations;the method comprising:stacking the first and second drum bodies such that the first drum body is nested in the interior of the second drum body to thereby define a drum body stack, and
stacking the first and second lids to thereby define a lid stack,
wherein the first and second lids are stacked such that castellations of the first lid are received in the gaps between the plurality of castellations of the second lid.

US Pat. No. 10,167,112

PROTECTING PALLET BLOCKS

International Business Ma...

1. A block protector assembly comprising:a protector contoured to conform to a block of a pallet wherein the pallet comprises a plurality of blocks,
wherein the protector comprises a rigid material,
wherein the protector includes at least one protruding flange that is configured to extend past the block of the pallet such that the protruding flange is configured to cover a deck of the pallet,
wherein the protruding flange is designed to distribute an impact force to both the deck of the pallet and the block of the pallet,
wherein the protector includes four sides, a first side, a second side including two flat portions and a curved portion, a third side including two flat portions and a curved portion, and a fourth side,
wherein at least one dimension between the curved portion of the second side and the curved portion of the third side is smaller than a corresponding dimension across the block of the pallet; and
an attachment mechanism coupled to the protector,
wherein the attachment mechanism is configured to secure the protector to the block of the pallet by a friction fit,
wherein the attachment mechanism includes one or more prongs,
wherein the one or more prongs are designed to fit on a back side of the block of the pallet.

US Pat. No. 10,167,111

TAMPER-EVIDENT REUSABLE PACKAGE CLOSURE

VELCRO BVBA, Deinze (BE)...

1. A reusable closure system, comprising:a base configured to be bonded to underlying package material and including a first field of touch fasteners having one or more cut-lines therein defining a hinged pull-tab assembly; and
a hinged lid configured for movement between open and closed positions relative to the base and including a second touch fastener field that is complementary to the first touch fastener field, such that the first and second touch fastener fields engage with one another to provide a secure closure when the lid is in the closed position;
wherein upon opening of the lid, the hinged pull-tab assembly is exposed so that the pull-tab assembly can be selectively peeled back to its hinge while simultaneously removing a frangible region of the packaging material to which the base can be bonded to form a resulting hole in the packaging material, and so that the peeled-back pull-tab assembly can be securely stowed against the lid by operation of the first and second touch fastener fields thereby providing a lid-based plug configured to engage the resulting hole in the packaging material when the lid is in the closed position.

US Pat. No. 10,167,110

DUAL HEIGHT COLLAPSIBLE CONTAINER

REHRIG PACIFIC COMPANY, ...

14. A collapsible container comprising:a base; and
a plurality of walls, pivotably connected to the base and pivotable between an upright position and a collapsed position on the base, a periphery of the base of the collapsible container includes a plurality of alternating recesses and projections complementary to a plurality of alternating recesses and projections at an upper edge of the plurality of walls, wherein the plurality of alternating recesses and projections on the periphery of the base and on the upper edge of the plurality of walls are configured such that an identical container can be stacked in a first orientation and in a second orientation, 180 degrees from the first orientation, on the collapsible container while the plurality of walls of the collapsible container are in the upright position, and such that identical container would be at a first height in the first orientation and at a second height in the second orientation, wherein the first height is different from the second height.

US Pat. No. 10,167,108

ADJUSTABLE ATTACHMENT CLIP FOR A SHIPPING CRATE

Great Northern Corporatio...

13. A shipping crate, comprising:a top frame;
a bottom frame;
a plurality of corner uprights extending between the top frame and the bottom frame at each of four corners;
at least one cross support extending between the top frame and the bottom frame; and
an attachment clip configured to connect the cross support to either the top frame or the bottom frame, the attachment clip comprising:
a center wall extending between a first end and a second end;
a first wall connected to the first end and extending perpendicular to the center wall;
a second wall connected to the second end and extending perpendicular to the center wall;
a front wall connected to the second wall and extending from the second wall to form a first receiving cavity between the front wall and the center wall and sized to receive one of the top frame or the bottom frame;
a back wall connected to the first wall and extending from the first wall to form a second receiving cavity between the back wall and the center wall and sized to receive the cross support;
a guard wall connected to the first wall and extending from the first wall, wherein the guard wall is spaced from the back wall to define a receiving cavity between the guard wall and the back wall; and
at least a pair of connectors extending through the front wall, the center wall and the back wall.

US Pat. No. 10,167,107

CONTAINER OR SET OF CONTAINERS

4. A set of containers comprising:a first container for storing and displaying one or more items; and
a second container for storing and displaying one or more items, the second container being positionable on said first container in a position in which at least one item is visible and removable from the first container,
wherein at least one wall of the first container or second container includes at least one cut out or slot arranged to receive at least one wall of the other of the first container or the second container, and
wherein the second container overhangs or protrudes from the first container when the second container is in the position.

US Pat. No. 10,167,106

STORAGE BOX WITH FILL VIEWER

Valvoline Licensing and I...

1. A storage box having a vertical sight port for viewing the volume of an internally stored collapsible container comprising a box having at least three side walls for housing a collapsible container having a dispensing apparatus at its base to control the flow of contained material from said collapsible container; said box having an interior height, width, and depth; said box further possessing flaps which fold together to close at least one side wall of said box, said flaps being configured so as to fold to form a side wall having a vertical sight port for observing the material level in said collapsible container, said vertical sight port created from combining the negative space from said flaps upon folding; and wherein at least one said flap possesses a dispensing apparatus port that permits the dispensing apparatus affixed to said collapsible container to pass through said side wall and below said vertical sight port for operation of said dispensing apparatus outside of said storage box.

US Pat. No. 10,167,105

APPARATUS FOR MANUFACTURE OF PACKAGING CONTAINER WITH RECLOSABLE CONNECTION AND METHOD OF MANUFACTURE

DISC GRAPHICS INC., Haup...

1. A method of manufacturing a reclosable container comprising:traversing a sheet of packaging material along a container forming device, wherein the sheet of packaging material includes a first segment, a second segment, a third segment, a fourth segment, a fifth segment, a sixth segment, and a seventh segment in order;
applying a magnet at the second segment;
applying a slug at the seventh segment;
applying glue in one or more locations on the sheet; and
folding the sheet of packaging material to form the reclosable container along a common border between the second segment and the third segment so that the magnet is aligned with the slug forming a reclosable connection, the second segment overlaps with the third segment, and the first segment overlaps with the fourth segment, the seventh segment, and at least a portion of the fifth segment.

US Pat. No. 10,167,104

MULTIPLE CONTAINER DEVICE

1. A container device comprising:a first container comprising a first base, a top member disposed opposite to the first base, and a first circumferential wall extending between the first base and the top member, the top member comprising one or more first openings;
a second container comprising a second base and a second circumferential wall extending from the second base, the second base comprising one or more second openings;
a cylindrical intermediate circumferential wall extending from a first one of a first portion of the first container including the top member or a second portion of the second container including the second base, the cylindrical intermediate circumferential wall adapted for slidably receiving a second one of the first portion and the second portion such that substantially all portions of facing surfaces of the top member and the second base abut each other and such that the first container and the second container are rotatable with respect to each other; and
at least one corresponding guide and track disposed on an interior vertical surface of the intermediate circumferential wall and an exterior vertical surface of the second one of the first portion and the second portion,
wherein the at least one corresponding guide and track are configured to restrict a rotary motion of the first container and the second container with respect to each other between an open position and a closed position,wherein the one or more first openings and the one or more second openings substantially overlap in the open position to define at least one passage between the first container and the second container, and wherein the one or more first openings and the one or more second openings are non-overlapping in the closed position,wherein abutting portions of the facing surfaces have corresponding shapes, the corresponding shapes being substantially corresponding parabolic surfaces, and
wherein the at least one corresponding guide and track are arranged to exert force against each other so as to cause substantially all portions of the facing surfaces of the top member and the second base to be pressed together to create a seal between the first container and the second container in at least the closed position.

US Pat. No. 10,167,103

PRINTING APPARATUS, CONTROL METHOD AND NON-TEMPORARY RECORDING MEDIUM

TOSHIBA TEC KABUSHIKI KAI...

1. A printing apparatus comprising:a detection section configured to at least detect that a label is completely peeled from a mount;
a control section configured to:
start a back feed of the mount after elapse of a start time period, and
control a value of the start time period; and
wherein the start time period is a time period since it is detected that the label was completely peeled from the mount.

US Pat. No. 10,167,102

APPARATUS FOR TRANSFERRING PROCESS MATERIAL BETWEEN A FIRST CONTAINER AND A SECOND CONTAINER, AND METHOD FOR THIS PURPOSE

Rubitec AG, Bennwil (CH)...

1. An apparatus for transferring process material between a first container and a second container, having:a) at least one tensioning unit, which has a first tensioner and a second tensioner, which can be actuated independently of one another; wherein:
b) the at least one tensioning unit is intended to temporarily fix, in a sealed-off manner:
ba) just an end portion, near to the tensioning unit, of a tubular liner piece, which extends indirectly between the containers, in order to seal off the transition between the containers from the exterior;
bb) just an end portion, near to the tensioning unit, of a tubular liner remainder left over from a previous transfer operation, which liner remainder is closed at the other end by a first crimp; and
bc) the end portion of the liner piece simultaneously with the end portion of the liner remainder left over from a previous transfer operation, wherein
c) both tensioners of the respective tensioning unit are intended to temporarily fix, in a sealed-off manner, jointly the near end portion of the liner piece or jointly the near end portion of the liner remainder left over from a previous transfer process; and
d) both tensioners of the respective tensioning unit are arranged circularly and concentrically with one another in relation to a longitudinal extension of the liner piece.

US Pat. No. 10,167,101

FILM PACKING DEVICE

Hsiu-Man Yu Chen, Taichu...

1. A film packing device comprising:a handle;
the handle comprising two ends, a coupling rod and a base;
the coupling rod and the base being provided on the two ends respectively,
the coupling rod comprising a retaining member; the retaining member comprising a first retaining portion and a second retaining portion
the base comprising a limit unit, the limit unit comprising a first limit portion and a second limit portion;
wherein a first film application unit and a second film application unit being interchangeably mounted and engaged with the handle;
the first film application unit comprising a first film seat and a second film seat, the first film seat and the second film seat being disposed oppositely; the first film seat comprising a first fixing portion; the first fixing portion corresponding to the second retaining portion;
the second film seat comprising a second fixing portion; the second fixing portion corresponding to the first limit portion; the second film application unit comprising an axial rod; the axial rod comprising a first positioning portion and a second positioning portion; the first positioning portion and the second positioning portion being disposed oppositely; the first positioning portion corresponding to the first retaining portion; the second positioning portion corresponding to the second limit portion;
in response to the handle being engaged with the first film application unit, the second retaining portion of the retaining member being engaged with the first fixing portion of the first film application unit and the first limit portion of the limit unit being engaged with the second fixing portion of the first film application unit;
in response to the handle being engaged with the second film application unit, the first retaining portion of the retaining member being engaged with the first positioning portion of the second film application unit and the second limit portion of the limit unit being engaged with the second positioning portion of the second film application unit;
in response to the handle being engaged with the first film application unit, the first film application unit being configured to be mounted with a roll of film with a paper reel; and
in response to the handle being engaged with the second film application unit, the second film application unit being configured to be mounted with a roll of film without a paper reel.

US Pat. No. 10,167,100

PACKAGE CONTAINING A COSMETIC PRODUCT

1. A package containing a cosmetic product, the package comprising a basic body, a neck and a closure member or product dispensing member mounted on the neck, so as to form an internal volume containing the cosmetic product, wherein the package resists an increase in pressure of at least 0.245 bar within the internal volume together with a rise in the temperature of the product to above 85° C., the package undergoing no plastic deformation as a result of said increase in pressure together with said rise in the temperature,the package comprising a shoulder joining the basic body to the neck, the basic body, the shoulder and the neck being formed integrally, the thickness of the shoulder being greater than the thickness of the central region of the basic body.

US Pat. No. 10,167,099

APPARATUS AND METHOD FOR EXPANDING AND ERECTING COLLAPSED OR FOLDED CARDBOARD PACKAGINGS TO STANDING ARRANGED COMPARTMENTS AND/OR OUTER PACKAGINGS

Krones Aktiengesellschaft...

1. An apparatus (01) for expanding and erecting collapsed or folded cardboard packagings (02) to standing compartments and/or outer packagings (03), comprising:a cardboard packaging supply (04) comprising at least one stack (41) of flatly collapsed cardboard packagings (02) arranged lying on top of each other,
an erecting device (05) arranged next to the cardboard packaging supply (04) as seen in the direction of a horizontal axis (11), and
a gripping device (06) for the simultaneous seizing one topmost cardboard packaging (02) from each stack (41) of the cardboard packaging supply (04), wherein:
the cardboard packagings (02) comprise a plurality of cardboard packaging walls (22) interconnected with each other, one forming a top flat side (23) and one forming a bottom flat side (24) of a flatly collapsed cardboard packaging (02),
the gripping device (06) has at least one tool (61) for holding the top flat side (23) of the cardboard packaging wall (22),
the gripping device (06) has at least one manipulator (62) with a manipulator head (63) that is at least movable along a horizontal axis (11), wherein the at least one tool (61) is arranged at the manipulator head (63) so that the at least one tool (61) is movable at least horizontally between the cardboard packaging supply (04) and the erecting device (05),
the erecting device (05) has at least one carrier (51) that is rotatable about a horizontal pivoting axis (13) from a horizontal position to a vertical position and vice versa,
the erecting device (05) has at least one tool (52), arranged at its at least one carrier (51), for each cardboard packaging (02) that is simultaneously seizable by the gripping device (06),
the at least one tool (52), in its horizontal position, seizes each cardboard packaging (02), at its bottom flat side (24),
each cardboard packaging (02) is expanded to a set of compartments and/or to an outer packaging (03) by an increase of the distance between the at least one tool (61) of the gripping device (06) and the at least one tool (52) of the erecting device (05) along a vertical axis (12), and
the at least one tool (52) holds each cardboard packaging (02) at least until the at least one carrier (51) has rotated about the horizontal pivoting axis (13) from its horizontal position into its vertical position so that access openings through which articles can be introduced into the expanded compartments and/or outer packaging (03) are in a vertical plane.

US Pat. No. 10,167,098

BOX FILLER FOR PRODUCE PACKAGING

1. An apparatus for metering produce into a plurality of individual containers aligned in multiple rows within a plurality of packing boxes comprising:a frame structure;
a box conveyer supported by the frame structure for moving the plurality of packing boxes successively over the length of the apparatus;
a produce conveyer supported suspended over the box conveyer for moving produce over the plurality of packing boxes;
a metering gate supported by the frame structure adjacent to the produce conveyer for selectively metering produce from the produce conveyer into the individual containers of each successive row within each of the plurality of packing boxes;
a weigh/fill assembly supported by the frame structure beneath the box conveyer, the weigh/fill assembly includes an elongated deck part over which the box conveyer moves the plurality of packing boxes and a weigh/fill scale operatively coupled to the deck part for measuring the weight of one of the plurality of packing boxes as produce is metered into the individual containers of each successive row within the one of the plurality of packing boxes while the one of the plurality of packing boxes is moved over the deck part by the box conveyer, the deck part has an upstream end and a downstream end;
a plurality of box lifters supported by the frame structure and each independently moveable between a lowered position and a raised position for lifting the others of the plurality of packing boxes adjacent the one of the plurality of packing boxes out of contact with the deck part while produce is metered into the one of the plurality of packing boxes and the others of the plurality of packing boxes adjacent to the one of the plurality of packing boxes extend partially over the deck part, the plurality of box lifters include a first box lifter supported by the frame structure adjacent the upstream end of the deck part, a second box lifter supported by the structure adjacent the downstream end of the deck part, and a third box lifter supported by the frame structure beneath the deck part between the first box lifter and the second box lifter, the third box lifter extending upward through the deck part when the third box lifter is in the raised position; and
a controller for actuating the box conveyer to incrementally move the plurality of packing boxes to successive positions across the length of the apparatus thereby positioning each row of the plurality of individual containers below the metering gate and for actuating the metering gate produce into the plurality of individual bags in response to the weigh/fill scale.

US Pat. No. 10,167,097

APPARATUS FOR FORMING GROUPS OF PRODUCTS

CAVANNA S.P.A., Prato Se...

1. Apparatus for forming groups of products, comprising:a belt conveyor having a transport surface movable in a longitudinal direction, wherein said transport surface terminates in an outlet edge where the products advancing on said transport surface fall by gravity;
a plurality of receiving elements having respective seats elongated along respective axes parallel to each other and parallel to said longitudinal direction, wherein said receiving elements are movable between a closed position in which the receiving elements are configured to receive and retain products in their respective seats and an open position in which the receiving elements are configured to release respective groups of products in a vertical direction; and
a plurality of guide devices associated with respective receiving elements and configured for guiding products that fall from said outlet edge to respective receiving elements, wherein the outlet edge of the belt conveyor and said receiving elements are provided with a stepped relative movement in said longitudinal direction, so that subsequent products that fall from the outlet edge of the belt conveyor are received in offset positions in said seats of said receiving elements.

US Pat. No. 10,167,096

PACKING MACHINE CORE AND STRAP CUTTING AND IRONING ADHERING METHOD

HANGZHOU YOUNGSUN INTELLE...

1. A packing machine core, comprising: a control mechanism, a packing strap ironing adhering and strap cutting mechanism, an ironing adhering sliding plate mechanism, and a machine core bracket, wherein the control mechanism comprises a machine core mainshaft and a mainshaft motor, multiple control cams are mounted on the machine core mainshaft and are for controlling the ironing adhering and strap cutting mechanism, the multiple control cams including a first cam for controlling a swinging arm of the ironing adhering sliding plate mechanism, a left cutter cam, a middle cutter cam, a right cutter cam, and a second cam for controlling a swinging arm of an ironing head to work, the mainshaft motor drives the machine core mainshaft to rotate;the packing strap ironing adhering and strap cutting mechanism is provided with a left cutter, a middle cutter and a right cutter, the left cutter, the middle cutter and the right cutter move upward or downward, and the machine core bracket is provided with a guide structure for guiding the left cutter, the middle cutter and the right cutter to move upward or downward;
the right cutter has a support head for supporting the packing strap and a hole, positioned underneath the support head of the right cutter, the packing strap passes through the bole, wherein a height of the hole is high enough to ensure that when a lower sliding plate is positioned above the middle cutter, the hole is pluggable by a limit slot in the lower sliding plate; the middle cutter has a support head thereof for supporting the packing strap, and a strap cutting fit is formed between an upper margin at a right side of the middle cutter and an upper margin at a left side of the hole mouth; and the left cutter has a support head thereof for supporting the packing strap;
the swinging arm of the ironing adhering sliding plate mechanism and the swinging arm of the ironing head each is respectively positioned at a first side and a second side of the machine core, the left cutter, the middle cutter and the right cutter are positioned between the swinging arm of the ironing adhering sliding plate mechanism and the swinging arm of the ironing head, the first side is either of a front side and a rear side of the machine core, and the second side is either of the front side and the rear side of the machine core, the front side and the rear side of the machine core are arranged along an extension direction of the machine core main shaft, the rear side is closer to the mainshaft motor than the front side;
the ironing adhering sliding plate mechanism comprises an upper sliding plate, a lower sliding plate and a sliding guide structure, wherein a front part of the lower sliding plate is corresponding to the middle cutter, a front part of the upper sliding plate is corresponding to the left cutter, the middle cutter and the right cutter, and the lower sliding plate is connected to a head limit part of a packing strip and a corresponding sensing element; the sliding guide structure comprises an upper guide structure for guiding the upper sliding plate to slide and a lower guide structure for guiding the lower sliding plate to slide; the sliding plate mechanism is further provided with a lower sliding plate seat on which the lower sliding plate is mounted, the swinging arm of the ironing adhering sliding plate mechanism is connected to the lower sliding plate seat, the lower sliding plate slides relatively to the upper sliding plate, and the ironing adhering sliding plate mechanism is provided with a limit structure between the upper sliding plate and the lower sliding plate; an upper packing strip transport gap exists between the front part of the lower sliding plate and the upper sliding plate, the limit part is correspondingly positioned at a left side of the strip transport gap, the front part of the lower sliding plate is provided with a lower packing strip transport limit slot, a mouth of which is open toward a direction of the front part; a retaining part is disposed at a position on the machine core bracket, where the guide structure for guiding the left cutter, the middle cutter and the right cutter to move upward or downward is disposed, the retaining part is corresponding to the mouth of the limit slot, and the strip transport gap is positioned at the mouth of the limit slot;
the limit structure comprises a relative movement limit slot arranged on and through the lower sliding plate and a limit fitting piece, the limit fitting piece is connected to a bottom of the upper sliding plate through the relative movement limit slot;
the limit structure is configured to limit a movement distance of the lower sliding plate relative to the upper sliding plate, before the lower sliding plate slides backward from a position of an initial state thereof to a middle position, the limit structure does not obstruct the lower sliding plate to slide backward so that the upper sliding plate keeps in a position of an initial state; when the lower sliding plate slides backward from the middle position, the limit structure obstructs the lower sliding plate so that the upper sliding plate is driven to slide backward together with the lower sliding plate to an open state, the middle position is a position where the lower sliding plate is separated from the lower packing strap at the limit slot thereof; and
a position of the ironing head in a left and right direction is corresponding to a position between the right cutter and the retaining part.

US Pat. No. 10,167,095

BRAKE SYSTEM OF WIRE REEL IN REINFORCING BAR BINDING MACHINE

MAX CO., LTD., Tokyo (JP...

1. A reinforcing bar binding machine which includes a binding machine body, wherein the reinforcing bar binding machine feeds a wire fed from a wire reel rotatably supported on the binding machine body, winds the fed wire about reinforcing bars, and twists the wire to bind the reinforcing bars, the reinforcing bar binding machine comprising;a shaft that is supported by the binding machine body;
a stopper lever that includes a hole into which the shaft is inserted, that is rotatable about the shaft, that includes a lacking portion which is engageable with the wire reel, wherein, by rotation of the shaft, the locking portion is movable between an engaged position at which the locking portion engages with the wire reel to brake the wire reel and a disengaged position at which the locking portion releases the wire reel so that the wire reel is rotatable;
a solenoid that is arranged to be slidable, that includes a core which is connected to the stopper lever and that rotates the stopper lever through the shaft by slide of the solenoid; and
a cover that partitions a portion between the wire reel and the solenoid.