US Pat. No. 10,113,475

SHUNT TANK ASSEMBLY

Caterpillar Inc., Deerfi...

1. A drop tube for a shunt tank, the drop tube defining a channel along a central axis therethrough, the drop tube comprising:a plug portion having a first length;
a flange provided at a first end of the plug portion;
a transition portion provided at a second end of the plug portion, the transition portion is tapered with respect to the plug portion; and
a tube portion extending from the transition portion and terminating with a chamfered end, the tube portion has a second length greater than the first length of the plug portion, the tube portion is made of elastomeric material and configured to bend without kinking,
wherein a maximum outer diameter of the tube portion at the chamfered end, which is where coolant exits and/or enters the tube portion, is less than a maximum outer diameter of the flange and a maximum outer diameter of the plug portion, and
wherein, in a side view, a sidewall of the chamfered end of the tube portion forms a point as an end-most portion of the chamfered end.

US Pat. No. 10,113,474

COOLING DEVICE FOR INTERNAL COMBUSTION ENGINE

DENSO CORPORATION, Kariy...

1. A cooling device for an internal combustion engine, the cooling device including a bypass passage that circulates cooling water for cooling the internal combustion engine to bypass a radiator, the cooling device comprising:an outflow temperature sensor that detects an outflow temperature of the cooling water flowing out from a cooling-water outlet of the internal combustion engine;
a flow control valve that adjusts a flow rate of the cooling water flowing in the bypass passage; and
a control device that controls the flow control valve to be open or closed, wherein
the control device, during a warming of the internal combustion engine, controls the flow control valve to be open or closed based on information about a change rate of the outflow temperature to prevent the change rate of the outflow temperature from decreasing to a minus value, after opening the flow control valve and starting a circulation of the cooling water in a route passing through the bypass passage,
the control device opens the flow control valve to start the circulation of the cooling water in the route passing through the bypass passage when the outflow temperature becomes equal to or higher than a specified value during the warming of the internal combustion engine, and
the control device performs an open/close control routine to repeat:
closing the flow control valve when the information about the change rate of the outflow temperature becomes equal to or higher than a first threshold value; and
opening the flow control valve when the information about the change rate of the outflow temperature becomes equal to or lower than a second threshold value that is smaller than the first threshold value.

US Pat. No. 10,113,473

COOLING SYSTEM FOR AN ELECTRICALLY DRIVEN VEHICLE

RENAULT s.a.s., Boulogne...

1. A cooling system for a motor vehicle including electrical propulsion, comprising:a central processing unit;
a cooling circuit comprising at least one pump for circulating a coolant;
a solenoid valve; and
a radiator;
the cooling circuit configured to cool a battery charger and an electric motor associated with an electronic control device;
wherein the central processing unit is configured to receive diagnostic information including a partial failure status for said at least one pump and phase of use information indicating a phase of use of the vehicle, and manage activation of each pump based on the received diagnostic information and phase of use information, which includes optimizing use of said-partial failure status of each of the pumps.

US Pat. No. 10,113,469

METHOD OF PROTECTING A DIESEL PARTICULATE FILTER FROM OVERHEATING

Ford Global Technologies,...

7. A vehicle comprising:a diesel engine;
an electric machine connected to the engine;
a battery connected to the electric machine;
a diesel particulate filter (DPF) arranged to receive engine exhaust gas; and
a controller programmed to control the engine and the electric machine to reduce oxygen content of the engine exhaust gas in response to a DPF temperature exceeding a threshold during DPF regeneration while the engine is idling.

US Pat. No. 10,113,463

REMOTE FLUID SUPPLY FOR AN ENGINE

Clark Equipment Company, ...

1. A system comprising:a first diesel engine operable to drive a first device;
a first diesel exhaust fluid (“DEF”) tank associated with the first engine and operable to provide DEF to the first diesel engine during operation;
a second diesel engine operable to drive a second device;
a second DEF tank associated with the second engine and operable to provide DEF to the second diesel engine during operation;
an external DEF tank arranged to contain a quantity of DEF that is coupled to the first DEF tank and the second DEF tank and operable to selectively deliver DEF from the external DEF tank to each of the first DEF tank and the second DEF tank;
a manifold including an inlet fluidly connected to the external DEF tank, a first outlet fluidly connected to the first DEF tank, and a second outlet fluidly connected to the second DEF tank;
a first valve associated with the first outlet, the first valve configured to move between a closed position in which no DEF flows through the first outlet and an open position in which DEF flows through the first outlet; and
a second valve associated with the second outlet, the second valve configured to move between a closed position in which no DEF flows through the second outlet and an open position in which DEF flows through the second outlet.

US Pat. No. 10,113,459

INERTIAL GAS-LIQUID IMPACTOR SEPARATOR WITH FLOW DIRECTOR

Cummins Filtration IP Inc...

1. An inertial gas-liquid impactor separator for removing liquid particles from a gas-liquid stream comprising a housing having an inlet for receiving a gas-liquid stream and an outlet for discharging a gas stream, at least one nozzle in said housing receiving said gas-liquid stream from said inlet and accelerating said gas-liquid stream through said at least one nozzle, an inertial impactor collector in said housing in the path of said accelerated gas-liquid stream and causing liquid particle separation, and a flow director directing flow through said housing from said inlet to said outlet along a flow path from upstream to downstream, said flow director comprising a resiliently biased plunger having a valve face engageable with a valve seat, at least one of said valve face and said valve seat having a self-seating tolerance-accommodating configuration.

US Pat. No. 10,113,457

CAMSHAFT MODULE

Hyundai Motor Company, S...

1. A camshaft module comprising:a head cover in which a camshaft is seated;
a cylinder head with an upper portion coupled to a lower portion of the head cover, and with a plurality of cam followers, operated according to a rotation of the camshaft, formed on the upper portion; and
a gasket between the head cover and the cylinder head, the gasket having a plurality of cam holes formed therein, the cam followers penetrating through the plurality of cam holes, and having supporting parts formed to protrude so as to prevent a falling of the cam followers around the plurality of cam holes.

US Pat. No. 10,113,454

CONTROL DEVICE OF ENGINE

MITSUBISHI JIDOSHA KOGYO ...

1. A control device of an engine, the engine including: a piston which is contained in a cylinder; an intake passage which is communicated to a combustion chamber of the cylinder; an exhaust passage which is led from the combustion chamber; a fuel injection valve which is configured to inject fuel to the combustion chamber or the intake passage; and an ignition unit which is provided in the combustion chamber, the control device comprising:a low speed pre-ignition predicting unit which is configured to perform prediction of occurrence of low speed pre-ignition, based on operation condition of the engine;
a lubricating oil injection controlling unit which is configured to control a lubricating oil injecting device to inject lubricating oil to the piston or a member located around the piston, based on the prediction of the occurrence of the low speed pre-ignition performed by the low speed pre-ignition predicting unit;
a self ignition index calculating unit which is configured to calculate self ignition index which indicates possibility of occurring self ignition of the fuel at a crank angle before an ignition time during a compression stroke, based on temperature and pressure inside the combustion chamber; and
a first correction coefficient calculating unit which is configured to calculate a wall face adhered fuel correction coefficient for correcting the self ignition index, based on an amount of fuel that is adhered to a wall face inside the combustion chamber at the crank angle, wherein
the low speed pre-ignition predicting unit is configured to perform the prediction of the occurrence of the low speed pre-ignition, based on the self ignition index calculated by the self ignition index calculating unit and the wall face adhered fuel correction coefficient.

US Pat. No. 10,113,446

ROTARY MACHINE SYSTEM

MITSUBISHI HEAVY INDUSTRI...

1. A rotary machine system comprising:a first rotary machine including a driving shaft capable of being driven about an axis;
a second rotary machine including a driven shaft rotatable about the axis and a bearing device slidably supporting the driven shaft on an axial end portion side with a pad surface such that lubricating oil is supplied to the pad surface;
a coupling unit connecting the driving shaft and the driven shaft to each other such that rotation of the driving shaft is transmitted to the driven shaft; and
a baffle plate disposed between the bearing device and the coupling unit and separating a space on the bearing device side and a space on the coupling unit side from each other, wherein
the second rotary machine includes a casing provided with a tubular portion that has a tubular shape and forms a gap in a radial direction between the tubular portion and the baffle plate,
the baffle plate includes a plurality of support units disposes at intervals in a circumferential direction,
the baffle plate is supported by an inner peripheral surface of the casing via the support units, and
the tubular portion has a discharge part that is configured to discharge the lubricating oil.

US Pat. No. 10,113,445

ROTARY MACHINE AIR DEFLECTOR

Hamilton Sundstrand Corpo...

8. A method for cooling a bearing positioned around a rotating shaft, the method comprising:providing air to a cavity that surrounds the rotating shaft;
deflecting the air towards an innermost surface of the bearing that is positioned radially outward of the rotating shaft, wherein the air is deflected with an air deflector that is mounted on the rotating shaft, wherein the air deflector has a first cylindrical body portion that is connected to a second cylindrical body portion with a ramp portion, and wherein an inner surface of the first cylindrical body portion abuts an outer surface of the shaft; and
flowing the air between an outer surface of the air deflector and the innermost surface of the bearing.

US Pat. No. 10,113,444

HEATED INLET GUIDE VANE

UNITED TECHNOLOGIES CORPO...

1. An inlet guide vane of a gas turbine engine, comprising:an inlet cavity extending between a first end and a second end, the inlet cavity being in communication with a source of heated air,
an outlet cavity extending between the first end and the second end and located between the inlet cavity and a leading edge of the inlet guide vane,
an inner wall disposed between and separating the inlet cavity from the outlet cavity, the inner wall including a plurality of impingement holes providing communication between the inlet cavity and the outlet cavity,
a plurality of bleed holes providing communication between the outlet cavity and an outer surface of the inlet guide vane;
wherein the plurality of bleed holes and the plurality of impingement holes are located such that heated air travelling from the inlet cavity to the outlet cavity through the inner wall via at least one of the plurality of impingement holes will exit from the outlet cavity through one of the plurality of bleed holes prior to it travelling along the entire length of the outlet cavity and wherein airflow into the outer cavity and out of the outer cavity is only provided by the plurality of impingement holes and the plurality of bleed holes.

US Pat. No. 10,113,442

METHOD OF RELEASING A FAN BLADE AND ASSEMBLY FOR RELEASING A FAN BLADE FROM A TURBOFAN ENGINE

Rolls-Royce Corporation, ...

1. A method of releasing a fan blade for testing a turbofan engine, comprising:providing a blisk airfoil;
providing a hole in the blisk airfoil at least partially aligned with a contour of the blisk airfoil;
packing the hole with an explosive charge such that at least an outside portion of the explosive charge is surrounded by the blisk airfoil and disposed within the hole;
modifying the blisk airfoil such that at least a portion of the blisk airfoil is releasable along a chordwise length of the blisk airfoil; and
detonating the explosive charge such that at least substantially all of the portion of the blisk airfoil is released at a selected time.

US Pat. No. 10,113,440

THERMOACOUSTIC ELECTRIC GENERATOR SYSTEM

CENTRAL MOTOR WHEEL CO., ...

1. A thermoacoustic electric generator system comprising:a tube component that is configured by including: an annular tube configured to be annular; and a branched tube branched from the annular tube, extending lengthwise from one end, which is located at a branched point from the annular tube, to the other end, and communicating with the annular tube and, in which specified working gas is enclosed in both of the annular tube and the branched tube;
a thermoacoustic engine that includes: a stack incorporated in an inside of the annular tube in the tube component and having plural channels, each of which extends in a tube longitudinal direction; and a heat exchanger exchanging heat with the working gas such that a temperature gradient is generated between both ends of each of the plural channels in the stack, so as to cause thermoacoustic oscillation of the working gas;
a turbine provided in the branched tube of the tube component and rotating when receiving acoustic energy, which is generated by thermoacoustic oscillation of the working gas in the thermoacoustic engines; and
a generator converting kinetic energy generated by rotation of the turbine to electric energy, wherein
the turbine is provided at a specified position that belongs to a region between a first position and a second position in each region of the branched tube in the tube component, the first position being an intermediate position between the one end and the other end, and the second position being an intermediate position between the first position and the other end.

US Pat. No. 10,113,439

INTERNAL SHROUD FOR A COMPRESSOR OF AN AXIAL-FLOW TURBOMACHINE

SAFRAN AERO BOOSTERS SA, ...

1. An inner shroud or inner shroud segment for an axial-flow turbine engine, the shroud or the shroud segment comprising:a circular or semi-circular wall, of which the profile extends essentially axially, and
a row of apertures formed in the circular or semi-circular wall, each aperture exhibiting opposing edges intended to be disposed laterally to either side of a stator vane positioned in said aperture for the purpose of its attachment,whereinsaid wall comprises at least one radial flange which passes through the apertures in the circumferential direction of the shroud or of the shroud segment, so as to form a mechanical link within each aperture in order to join the opposing edges thereof, andat least one radial flange comprises at least one surface having areas of roughness forming a pattern that is repeated on substantially an entire face of the corresponding radial flange, said surface being generally perpendicular to an axis of revolution of the shroud or of the shroud segment.

US Pat. No. 10,113,437

MULTI-PIECE SEAL

UNITED TECHNOLOGIES CORPO...

1. A seal for sealing a space defined by first and second adjacent components disposed about an axial centerline, the seal comprising:a first seal section including a first leg, a second leg, and at least one convolution between the first and second legs;
a second seal section including a third leg, a fourth leg, and at least one convolution between the third and fourth legs; and
a third seal section including a fifth leg, a sixth leg, and at least one convolution between the fifth and sixth legs;
wherein an end of the third leg is located between the first leg and the second leg and the second leg is in contact with a portion of the third leg proximate to the end of the third leg and an end of the fourth leg is located between the fifth leg and the sixth leg and a portion of the fourth leg proximate to the end of the fourth leg is in contact with the fifth leg;
wherein the first seal section sealingly engages with the first component and the third seal section sealingly engages with the second component.

US Pat. No. 10,113,435

COATED GAS TURBINE COMPONENTS

United Technologies Corpo...

1. A method of forming a gas turbine engine component subject to extreme temperatures and pressures, the method comprising:fabricating a wall having a first surface and a second surface which define opposite sides of the wall;
creating an airflow aperture that extends through the wall in a direction substantially perpendicular to the first surface, the airflow aperture defined by an aperture wall surface which extends from a first opening in the first surface to a second opening in the second surface, and which is flared at a juncture with the first surface such that the first opening has a greater cross-sectional flow area than the second opening; and
depositing a high-pressure, high-temperature resistant coating on the first surface, adhered to a portion of the aperture wall surface adjacent the first opening, such that a minimum flow width w of the airflow aperture is reduced and defined by the high-pressure, high-temperature resistant coating, where
Wmajor is a maximum uncoated width of the airflow aperture, Wminor is a minimum uncoated width of the airflow aperture, t is a thickness of the high-pressure, high-temperature resistant coating, and ? is a surface angle between the aperture wall surface and a line normal to the first surface.

US Pat. No. 10,113,433

GAS TURBINE ENGINE COMPONENTS WITH LATERAL AND FORWARD SWEEP FILM COOLING HOLES

HONEYWELL INTERNATIONAL I...

1. An engine component, comprising:a body having an internal surface and an external surface, the internal surface at least partially defining an internal cooling circuit; and
a plurality of cooling holes formed in the body and extending between the internal cooling circuit and the external surface of the body, the plurality of cooling holes including a first cooling hole with forward diffusion and lateral diffusion,
wherein the first cooling hole includes an inlet at the internal cooling circuit, a metering section extending from the inlet, a first exit portion extending from the metering section, a second exit portion extending from the first exit portion, and an outlet defined on the external surface and fluidly coupled to the second exit portion, wherein the metering section is an oval-shaped cylinder,
wherein the first exit portion extends at a first angle relative to the metering section and the second exit portion extends at a second angle relative to the metering section, the second angle being greater than the first angle to provide the forward diffusion,
wherein the outlet is a multi-lobe shape formed by a first oval, a second oval, and a third oval, each oval having a first end and a second end, wherein the first ends of the first oval, the second oval, and the third oval at least partially overlap, and wherein the second ends of the first oval, the second oval, and the third ovals are splayed relative to one another to provide the lateral diffusion.

US Pat. No. 10,113,429

LIQUID-CAPTURING SHAFT

ROLLS-ROYCE plc, London ...

1. A liquid-capturing shaft, the shaft being hollow, arranged for rotation about a longitudinal axis of the shaft, comprising:a wall defining an innermost surface and an outermost surface of the shaft and through which are formed a plurality of circumferentially spaced apart inlet openings; and
each inlet opening having a respective capture surface which extends from the outermost surface of the shaft and through the innermost surface of the shaft, such that the capture surface extends through the wall along a plane that extends obliquely with respect to the longitudinal axis.

US Pat. No. 10,113,427

VANE HEAT ENGINE

1. A vane motor comprising:a housing comprising a fixed outer wall having:
an entrance face;
a ledge face;
an expansion face;
a return face;
an exit face; and
an annular face;
a rotor;
an expansion chamber wall, said expansion chamber wall having an axial length wherein said expansion chamber wall is flexible along the axial length, said expansion chamber wall being fixed in position relative to said entrance face and variable in position relative to said return face.

US Pat. No. 10,113,425

UNDERGROUND MINING SYSTEM FOR REDUCED COSTS, IMPROVED EFFICIENCIES, HIGHER PRODUCTIVITY AND A SAFER WORKING ENVIRONMENT THROUGH PENETRATED BLOCK EXTRACTION

Underground Extraction Te...

1. An underground mining method including the steps of forming:forming one or more sets of underground gate roads, each set of gate roads including at least two headings; and
forming underground dead-end plunge cuts extending from the sets of gate roads, each plunge cut formed with an unmanned continuous miner coupled to a flexible conveyor system and being greater than 30 meters in length with a roof that need not be supported;
sealing each dead-end plunge cut to form a ventilation barrier whilst still permitting entry of the continuous miner coupled to a flexible conveyor system; and
supplying inert gas to a cutting face of each plunge cut.

US Pat. No. 10,113,421

THREE-DIMENSIONAL FRACTURE ABUNDANCE EVALUATION OF SUBSURFACE FORMATIONS

Schlumberger Technology C...

1. A method of evaluating fracture abundance in a subsurface formation, the method comprising, using one or more hardware-based processors:defining a fracture network within a plurality of cells of a three-dimensional model of the subsurface formation using a plurality of geometric primitives;
determining an area of the plurality of geometric primitives within at least a subset of the plurality of cells by summing areas of individual geometric primitives within each of the subset of cells, wherein determining the area of the plurality of geometric primitives within the subset of the plurality of cells further includes:
organizing the plurality of geometric primitives within a spatially-organized data structure; and
accessing the spatially-organized data structure when summing areas of individual geometric primitives within each of the subset of cells to determine which of the plurality of geometric primitives are at least partially within each of the subset of cells; and
determining a fracture abundance parameter for the fracture network from the determined area of the plurality of geometric primitives.

US Pat. No. 10,113,419

ELECTROMAGNETIC TELEMETRY USING A TRANSCEIVER IN AN ADJACENT WELLBORE

Halliburton Energy Servic...

1. A system comprising:a downhole transceiver coupled to a well tool that is positionable in a wellbore for transmitting an electromagnetic signal with encoded data;
a first electrode positionable in an adjacent wellbore for receiving the electromagnetic signal and generating a first voltage in response to the electromagnetic signal;
a second electrode positionable in the adjacent wellbore or at a surface of the adjacent wellbore for receiving the electromagnetic signal and generating a second voltage in response to the electromagnetic signal;
a surface transceiver for coupled to a fiber optic cable and configured to determine a decoded version of the encoded data based on a voltage difference between the first electrode and the second electrode;
and
a material coupled to the fiber optic cable and the first electrode for changing a strain on the fiber optic cable in response to the voltage difference between the first electrode and the second electrode,
wherein the material and the first electrode form at least a portion of an electrical circuit that is positionable in the adjacent wellbore and electrically passive, and wherein the electrical circuit has an input impedance that is greater than 1 mega ohm.

US Pat. No. 10,113,418

METHODS AND SYSTEMS FOR SPECTRUM ESTIMATION FOR MEASURE WHILE DRILLING TELEMETRY IN A WELL SYSTEM

SCHLUMBERGER TECHNOLOGY C...

1. A method for configuring transmission signals in a measuring while drilling (MWD) wellbore tool, comprising:receiving at an earth surface, from a transmission of the MWD wellbore tool, a signal from the MWD wellbore tool in a wellbore, wherein the signal comprises a telemetry portion, comprising physical properties of the wellbore measured in the wellbore, and a noise portion;
reproducing the telemetry portion based at least partially on the signal;
subtracting the telemetry portion from the signal;
estimating, based at least partially on the subtraction, the noise portion of the signal; and
altering a transmission configuration of the downhole tool, for further transmitting the signal to the earth surface, based at least partially on the estimated noise portion of the signal.

US Pat. No. 10,113,417

APPARATUSES AND METHODS FOR EVALUATING SYSTEMS USED IN ELECTROMAGNETIC TELEMETRY TRANSMISSIONS

Evolution Engineering Inc...

1. A system for testing connectivity of an EM telemetry receiver to one or more ground conductors, the system comprising:a ground conductor in electrical contact with the ground;
a signal receiver electrically connected to the ground conductor by a link;
a test signal generator configured to generate an electrical test signal and to supply it to the ground conductor by way of the link;
a switch operable to selectively couple the link to the test signal generator or to the signal receiver; and
a meter configured to measure a current flowing from the test signal generator to the linkwherein the electrical test signal comprises a pure tone and the pure tone has a frequency of above 20 Hz.

US Pat. No. 10,113,416

MODELLING TOOL

1. A communication and data processing system for use between one or more employers and one or more system users and one or more system suppliers of the communication and data processing system, at least comprising:a) one or more downhole transmitters configured for providing LWD and/or MWD data,
b) the downhole transmitters communicating via a communication line with one or more computers upstream of the communication line through a data protocol for the transfer of MD and/or MWD data,
c) LWD and/or MWD data being stored locally at the one or more upstream computers,
d) data being transferred locally from the drilling installation to a central hub, the transfer being accomplished by wire or wirelessly via radio transceivers located on the installation and in communication with the central hub,
e) the central hub comprising a WITSML server
f) one or more mathematical models on the WITSML server for calculating an output function Hi(T), where Hi(T) denotes a function for increasing plant time efficiency and T denotes the true time spent in a project, wherein calculating Hi(T) at least includes using the following manipulated parameters:
g) TN: estimated time for completing the project,
T: actual time for completing the project,
Z: selected portion of total project value,
and at least one parameter obtained from the one or more downhole transmitters,
h) wherein, further, an application is implemented on the central hub, the application being configured for receiving parameters from the downhole transmitters comprising LWD and/or MWD data and other parameters relevant for the project, and the application being in direct communication with the mathematical model, or the application comprising the mathematical model,
i) one or more first computers having direct access to the hub and the WITSML server, operated by said one or more system suppliers,
j) one or more second presentation computers in communication with the one or more first computers, the second presentation computers at least receiving output functions Hi(T) from the one or more first computers and the output functions Hi(T) being selectively associated with individual second computers, and
k) wherein one or more system users are associated with the second computers.

US Pat. No. 10,113,415

METHODS AND APPARATUSES FOR DETERMINING TRUE VERTICAL DEPTH (TVD) WITHIN A WELL

Arthur H. Kozak, Edmonto...

1. A method of determining true vertical depth (“TVD”), within a well penetrating a ground surface, the method comprising:positioning a tubing string downhole such that a pressure sensor, located within an interior of the tubing string, is located at a base downhole position within the well at a base of a fluid column extended from a ground surface to the pressure sensor within the tubing string;
measuring, with the pressure sensor, or a plurality of pressure sensors that include the pressure sensor, a plurality of pressures exerted by the fluid column, in which the pressure is measured by the pressure sensor, or the plurality of pressure sensors, while fluid in the fluid column is stationary;
measuring a temperature of fluid in the fluid column at each of a series of positions to generate a series of temperature measurements, each associated with a respective position, of the series of positions, along the fluid column, in which the series of temperature measurements are taken while fluid in the fluid column is stationary;
generating a density profile of fluid along the fluid column based on the series of temperature measurements; and
determining the TVD of the base downhole position using the density profile of fluid along the fluid column to correct for density changes of fluid along the fluid column, and using the plurality of pressures measured by the pressure sensor or the plurality of pressure sensors.

US Pat. No. 10,113,414

MULTIPLE MAGNETIC SENSOR RANGING METHOD AND SYSTEM

SCHLUMBERGER TECHNOLOGY C...

1. A method for determining a geometric relationship of a second well with respect to a first well, comprising the steps of:producing a first output from a first 3-axis magnetometer positioned in the second well, the first output responsive to a magnetic field produced by a magnetic field source positioned in the first well;
producing a second output from a second 3-axis magnetometer positioned in the second well, the second output responsive to the magnetic field produced by the magnetic field source, wherein a location of the first 3-axis magnetometer and a location of the second 3-axis magnetometer relative to the magnetic field source are unknown;
calculating the location for each of the first and second magnetometers in the second well with respect to the magnetic field source in the first well; wherein the location of the first magnetometer and the location of the second magnetometer are determined from a plurality of magnetic field components measured by each said magnetometer;
transmitting the locations of the first and second 3-axis magnetometers to surface;
determining the geometric relationship of the second well with respect to the first well; and
reinitiating drilling operations based on the geometric relationship between the first and second wells.

US Pat. No. 10,113,413

METHOD AND APPARATUS FOR DETERMINING WELLBORE POSITION

Nabors Drilling Technolog...

1. A method for determining true vertical depth along a wellbore, the method comprising:determining wellbore inclination, azimuth, and drillstring length at a plurality of static survey points, the determining wellbore inclination further comprising determining wellbore inclination from linear acceleration values determined by one or more sensors for measuring linear and gravitational acceleration;
determining inclination at a plurality of positions between two static survey points using continuous inclination measurements obtained while drilling the wellbore;
determining an interpolated azimuth value along a minimum curvature of a wellbore path at each of the plurality of positions using the azimuth values determined at the static survey points before and after each of the plurality of positions;
determining the drillstring length at each of the plurality of positions; and
using the inclination, azimuth, and measured depth values measured at the static survey points, together with continuous inclination values, corresponding interpolated azimuth values, and measured drillstring length at each of the plurality of positions between static survey points to model the wellbore path and determine a variation in true vertical depth along at least a portion of the wellbore.

US Pat. No. 10,113,412

AXIALLY-SUPPORTED DOWNHOLE PROBES

Evolution Engineering Inc...

1. A downhole assembly comprising:a drill string section having a bore extending longitudinally through the drill string section;
a downhole probe located in the bore of the section;
the probe supported in the bore by first and second spiders each spider comprising a rim, a hub and one or more arms extending between the hub and the rim, the hub formed to provide a bore passing through the hub, the first and second spiders spaced apart longitudinally within the bore, and the rim of at least one of the first and second spiders abutting a landing step in a wall of the bore;
wherein:
at least one of the first and second spiders is axially fixed to the drill string section and to the probe,
the first spider is coupled to an uphole end of the probe, the second spider is coupled to a downhole end of the probe, at least one of the first and second spiders is coupled non-rotationally to the probe and to the drill string section and the probe extends through the bores of the hubs of the first and second spiders such that first and second ends of the probe respectively project past the hubs of the first and second spiders.

US Pat. No. 10,113,411

BOREHOLE IMAGE GAP FILLING

SCHLUMBERGER TECHNOLOGY C...

1. A method, comprising:acquiring a borehole image corresponding to a sidewall surface of a borehole that penetrates a subterranean formation, wherein the subterranean formation comprises structural elements and a varying geophysical characteristic, wherein the borehole image is based on measurement of the geophysical characteristic around circumferential portions of the sidewall surface of the borehole, and wherein the borehole image comprises:
structure corresponding to the structural elements;
texture corresponding to the varying geophysical characteristic; and
coverage gaps in which the structure and texture are missing; wherein the coverage gaps correspond to circumferential portions of the sidewall surface of the borehole for which no measurement of the geophysical characteristic was obtained,
extracting trends from the borehole image, wherein the trends correspond to low pass information of the image and representing the structure;
reconstructing the missing structure within the gaps based on the extracted trends;
simulating the missing texture within the gaps based on the borehole image and the reconstructed structure; and
constructing a fullbore image based on the borehole image, the reconstructed structure within the gaps, and the simulated texture within the gaps.

US Pat. No. 10,113,410

SYSTEMS AND METHODS FOR WIRELESSLY MONITORING WELL INTEGRITY

ONESUBSEA IP UK LIMITED, ...

1. A subsea mineral extraction system, comprising:a subsea wellhead assembly configured to couple to a well;
a first electronic sensor module configured to be disposed in cement in a first annulus of the subsea wellhead assembly, wherein the first electronic sensor module comprises:
a first sensor configured to measure or detect a parameter related to an integrity of the well;
control circuitry configured to generate sensor feedback based on the parameter measured or detected by the first sensor; and
a first transmitter configured to wirelessly transmit the sensor feedback;
a first controller comprising a first receiver configured to wirelessly receive the sensor feedback from the first transmitter of the first electronic sensor module, and wherein the first controller is disposed on an outer annular surface of an outermost string of a plurality of strings of the subsea wellhead assembly; and
a second controller configured to receive the sensor feedback from the first controller and to provide one or more user-perceivable indications based on the sensor feedback, wherein the second controller comprises a processor, a memory, and a model stored on the memory and executable by the processor, wherein the processor is configured to execute the model to predict or estimate the integrity of the well based at least in part on the sensor feedback.

US Pat. No. 10,113,409

BORE MEASURING TOOL

16. A method for measuring a well bore wall comprising:providing a casing in line within a tool string;
displacing an engagement body within a central passage of said casing from a first position to a second position to compress and radially extend a plurality of longitudinally extending biasing elements connected thereto;
recording at least one measurement of the well bore wall with a sensor located on each of said radially extended biasing elements; and
wherein said central passage has a first portion proximate to a first end of said casing and a second portion at a middle thereof, wherein said second portion of said central passage is larger than said first portion.

US Pat. No. 10,113,408

INTEGRATED DRILLING CONTROL SYSTEM

Weatherford Technology Ho...

1. A method of performing controlled pressure drilling of a borehole in a formation with a drilling system according to a drilling plan, the method comprising:configuring, with a computerized control system, a setup of at least the drilling plan, the formation, and the drilling system;
performing the controlled pressure drilling of the borehole in the formation with the drilling system according to the drilling plan by: integrating the setup of the computerized control system with the drilling system, acquiring current data of at least the drilling system, and functioning the drilling system with the computerized control system using the acquired data in an operating mode for operational interaction with the drilling system;
switching, at the computerized control system, from the operating mode to a simulating mode in response to an event anticipated in the drilling operation according to the drilling plan for simulated interaction with the drilling system while continuing the controlled pressure drilling with the drilling system;
simulating the functioning of the drilling system with the computerized control system for a future time period using simulated data in the simulating mode; and
using a result from the simulated interaction in the operational interaction with the drilling system.

US Pat. No. 10,113,407

ELECTROCHEMICAL PRODUCTION OF METAL HYDROXIDE USING METAL SILICATES

Lawrence Livermore Nation...

1. An apparatus for forming metal hydroxide, comprising:a first container that has a top, said first container containing insoluble particles;
a second container that is larger than said first container wherein said first container is located inside of said second container, wherein said first container is a porous container that includes porous container walls that extend entirely around said first container except for said top and wherein said porous container walls are made of a grate having a porosity such that water molecules and ions can pass through said grate but insoluble particles can not pass through said grate and said insoluble particles will be retained within said first container;
a hydroxyl-producing cathode located inside said second container outside of said first container;
hydroxyl ions produced by said hydroxyl-producing cathode;
an acid-producing anode located inside said first container;
acid produced by said acid-producing anode;
a direct current electricity source connected to said hydroxyl-producing cathode and said acid-producing anode;
direct current electricity produced by said direct current electricity source in a direct current electricity path between said hydroxyl-producing cathode and said acid-producing anode;
a metal silicate mass located inside said first container, wherein said metal silicate mass is a metal silicate mass that has been ground, powdered, fractured, or drilled;
metal silicate contained in said metal silicate mass that is contacted by said acid produced by said acid-producing anode, or by said hydroxyl ions produced by said hydroxyl-producing cathode, or by both said acid produced by said acid-producing anode and by said hydroxyl ions produced by said hydroxyl-producing cathode, wherein said metal silicate constitutes pieces or particles composed partly or entirely of metal silicate;
a water solution located inside said first container and said second container, said water solution having an ion concentration, wherein said ion concentration is sufficient to allow said direct current electricity to pass in said direct current electricity path between said acid-producing anode and said hydroxyl-producing cathode; and
wherein said first container that is a porous container with porous container walls is located inside of said second container with said porous container walls inside of said second container, said porous container containing said water solution and containing said acid-producing anode, said metal silicate mass, and said metal silicate wherein said porous container walls are immersed in said water solution inside said first container and said second container, wherein said hydroxyl-producing cathode is located in said second container outside of said first container that is a porous container;
wherein said acid-producing anode and said hydroxyl-producing cathode are at least partially submerged in said water solution;
wherein said direct current electricity is applied across said acid-producing anode and said hydroxyl-producing cathode, said direct current electricity being of sufficient current and voltage to generate said hydroxyl ions at said hydroxyl-producing cathode and generate said acid at said acid-producing anode, said acid or said hydroxyl ions being of sufficient concentration to convert at least some of said metal silicate into metal ions and silicate ions;
wherein said silicate ions react with said acid produced by said acid-producing anode and form silica or silicic acid; and
wherein said metal ions react with said hydroxyl ions produced by said hydroxyl-producing cathode to form the metal hydroxide.

US Pat. No. 10,113,403

HEATER AND METHOD OF OPERATING

DELPHI TECHNOLOGIES, INC....

7. A method of operating a heating system, said heating system comprising a plurality of heaters, each of said plurality of heaters comprising 1) a housing, 2) a plurality of fuel cell stack assemblies each having a plurality of fuel cells which convert chemical energy from a fuel into heat and electricity through a chemical reaction with an oxidizing agent, and 3) a conductor electrically connecting said plurality fuel cell stack assemblies to an electronic controller, said method comprises:a) using said electronic controller and said conductor of one of said plurality of heaters to monitor and control electric current produced by said plurality fuel cell stack assemblies of said one of said plurality of heaters; and
b) using said electronic controller and said conductor of another one of said plurality of heaters to monitor and control electric current produced by said plurality fuel cell stack assemblies of said another one of said plurality of heaters;
wherein step a is performed independently of step b;
wherein said plurality fuel cell stack assemblies are located within said heater housing such that each fuel cell stack assembly of the plurality of fuel cell stack assemblies is spaced axially apart from adjacent fuel cell stack assemblies within said heater housing, and said conductor electrically connects said plurality of fuel cell stack assemblies to said electronic controller, said method further comprising:
c) using said electronic controller and said conductor of said one of said plurality of heaters to monitor and control electric current produced by said plurality of fuel cell stack assemblies of said one of said plurality of heaters; and
d) using said electronic controller and said conductor of said another one of said plurality of heaters to monitor and control electric current produced by said plurality of fuel cell stack assemblies of said another one of said plurality of heaters;
wherein step c is performed independently of step d;
wherein the method further comprises the step of operating said plurality of fuel cell stack assemblies of a given one of said plurality of heaters in series.

US Pat. No. 10,113,400

SEQUENTIAL FULLY IMPLICIT WELL MODEL WITH TRIDIAGONAL MATRIX STRUCTURE FOR RESERVOIR SIMULATION

Saudi Arabian Oil Company...

1. A computer implemented method of forming a model of determined well completion rates of component fluids of a subsurface reservoir from measured total well production by reservoir simulation of well production, at a time step during life of the subsurface reservoir, from a plurality of vertical wells in the subsurface reservoir with a coupled well reservoir simulator model, the reservoir simulator model having formation layers having unknown formation pressures and completion rates at the time step, the formation layers comprising vertical fluid flow layers having vertical fluid flow therefrom and flow barrier layers with no vertical fluid flow therefrom, the coupled well reservoir simulator model being organized into a plurality of cells including a plurality of well cells at locations of the vertical wells in formation layers of the reservoir, and a plurality of reservoir cells adjacent the well cells and the reservoir cells of the formation layers having unknown formation pressures, transmissibilities and completion rates at the time step, the method comprising the computer implemented steps of:forming a reduced system model of the plurality of vertical wells consisting of:
interval well cells between flow barrier layers of the reservoir assembled by combining vertically disposed well cells of the vertical flow formation layers having vertical fluid communication therebetween and being located between flow barrier layers in the coupled reservoir model; and
reservoir cells adjacent the interval well cells;
solving the reduced system model for bottom hole pressures of the plurality of wells;
solving by reservoir simulation the coupled well reservoir model of well cells and reservoir cells for layer completion rates of component fluids of the well cells of each of the formation layers of the coupled well reservoir model at the time step, based on a steady state volume balance relationship of the layer completion rates, formation pressures and transmissibilities, and treating the plurality of wells as having the determined bottom hole pressure;
determining a simulator total well production rate for the plurality of wells from the layer completion rates of the component fluids of the formation layers of the coupled reservoir model of the well at the time step;
comparing the simulator total well production rate for the plurality of wells with the measured total well production at the time step to determine if simulator convergence is achieved; and, if so,
forming a record of the layer completion rates of the component fluids for the layers at the well cells and of the determined total well production rate for the plurality of wells at the time step; and
if the results of the step of comparing indicate convergence is not achieved, iterating to the step of solving by reservoir simulation the coupled well reservoir model, determining a simulator total well production rate for the plurality of wells from the well completion rates of the component fluids, and comparing.

US Pat. No. 10,113,399

DOWNHOLE TURBINE ASSEMBLY

NOVATEK IP, LLC, Provo, ...

1. A downhole turbine assembly, comprising:a drill pipe capable of passing a fluid flow there through;
a turbine disposed within a sidewall of the drill pipe, the turbine including a plurality of blades having flat surfaces, at least one blade of the turbine including polycrystalline diamond;
a course capable of diverting a portion of the fluid flow to the turbine; and
an outlet capable of discharging the diverted portion of the fluid flow from within the drill pipe to an exterior of the drill pipe.

US Pat. No. 10,113,398

FUEL CELL APPARATUS AND METHOD FOR DOWNHOLE POWER SYSTEMS

SCHLUMBERGER TECHNOLOGY C...

1. A method for generating electricity in a drill string disposed within a wellbore, wherein the drill string comprises a turbine, a generator, and a fuel cell system, the method comprising:(i) generating electricity using the fuel cell system, wherein the fuel cell system generates electricity by producing an electrochemical reaction between hydrogen and oxygen within a fuel cell stack, wherein the fuel cell stack comprises: a first electrode; a second electrode; a proton exchange membrane located between the first electrode and the second electrode; and at least one water storage medium located between the proton exchange membrane and the second electrode;
(ii) retaining water produced by the electrochemical reaction within the fuel cell stack;
(iii) stopping the electrochemical reaction within the fuel cell stack;
(iv) circulating drilling mud through the wellbore;
(v) generating electricity using the generator, the turbine, and the circulating drilling mud; and
(vi) generating hydrogen and oxygen within the fuel cell stack by using the electricity generated in process (v) to electrolyze the water produced in process (i) and retained in process (ii).

US Pat. No. 10,113,392

TUBING PRESSURE INSENSITIVE SURFACE CONTROLLED SUBSURFACE SAFETY VALVE

Halliburton Energy Servic...

1. A hydraulic control system for controlling operation of a downhole valve comprising:a rod piston disposed within a housing,
wherein the rod piston and the housing form a first piston chamber, a second piston chamber and a third piston chamber, wherein a first piston chamber volume of the first piston chamber and a third piston chamber volume vary inversely as the rod piston is moved from one position to another in the housing;
a high tubing pressure branch, wherein the high tubing pressure branch delivers pressure to the first piston chamber, wherein the first piston chamber is between a first seal on a first distal end of the rod piston and a wall of the housing;
a single control line directed into the second piston chamber and a first storage chamber branch, wherein the single control line delivers a surface pressure to the second piston chamber, wherein the second piston chamber is between the first seal and a second seal on a first side of a middle portion of the rod piston, wherein the first storage chamber branch fluidically couples a first compartment of a storage chamber and the second piston chamber to maintain the first compartment and the second piston chamber at a first pressure;
a second storage chamber branch, wherein the second storage chamber branch fluidically couples a second compartment of the storage chamber and the third piston chamber, wherein a second pressure of the second compartment of the storage chamber is directed to the third piston chamber through the second storage chamber branch, wherein a compressible fluid maintains the second compartment of the storage chamber and the third piston chamber at a same pressure, and wherein the first compartment and the second compartment comprise a compressible fluid or a compressible gas; and
a flow tube coupled to the rod piston and a flapper,
wherein the flow tube moves between a first position and a second position in response to movement of the rod piston, and
wherein movement of the flow tube between the first position and the second position is operable to at least one of open the flapper and close the flapper.

US Pat. No. 10,113,391

RETRIEVABLE BACK PRESSURE VALVE AND METHOD OF USING SAME

1. A retrievable back pressure valve for use with a horizontal well completion operations during drilling out plug procedures comprising:a tool with a first end, a second end and a passageway there through wherein said tool is adapted to be removably positioned in a drill string profile nipple in said horizontal well;
at least one flapper valve positioned in said tool said passageway adapted to allow fluid to flow downhole of said horizontal well through said tool said passageway and prevent said fluid from traveling up said horizontal well through said tool said passageway; and
a releasable positioning mechanism attached to said tool for positioning said tool in said drill string profile nipple and adapted to release said tool from said drill string profile nipple when a ball is dropped down said horizontal well and enters said tool.

US Pat. No. 10,113,390

VALVE FOR GRAVEL PACKING A WELLBORE

SCHLUMBERGER TECHNOLOGY C...

1. A downhole tool, comprising:a housing comprising a screen; and
a valve system positioned within the housing, the valve system comprising a first valve and a flow control device, wherein the valve system has a first position where the first valve allows a flow within the housing, a second position where the first valve directs at least a portion of the flow through the flow control device, and a third position stopping flow through the flow control device; and
wherein the valve system further comprises an intermediate tubular member positioned between the housing and a base pipe, wherein the intermediate tubular member has a first opening formed radially-therethrough.

US Pat. No. 10,113,388

APPARATUS AND METHOD FOR PROVIDING WELLBORE ISOLATION

HALLIBURTON ENERGY SERVIC...

1. An actuatable wellbore isolation assembly comprising:a housing generally defining an axial flowbore and comprising a mandrel portion, a first end portion, and a second end portion, the mandrel portion being movable relative to the second end portion so that the housing has a variable length;
a radially expandable isolating member positioned circumferentially about a portion of the housing;
a sliding sleeve circumferentially positioned about a portion of the mandrel of the housing, the sliding sleeve being configured to be movable between:
a first position in which the sliding sleeve retains the expandable isolating member in a narrower non-expanded conformation; and
a second position in which the sliding sleeve does not retain the expandable isolating member in the narrower non-expanded conformation;
an actuator assemblage configured to move the sliding sleeve from the first position to the second position; and
a locking mechanism engaged to retain the sliding sleeve in the first position and disengageable to allow movement of the sliding sleeve between the first position and the second position,
wherein movement of the mandrel portion relative to the second end portion disengages the locking mechanism to thereby allow the actuator assemblage to move the sliding sleeve from the first position to the second position.

US Pat. No. 10,113,385

PRODUCTION SYSTEM AND TENSION HANGER

Cameron International Cor...

11. A well production system for producing fluids from a well, the system comprising:a wellhead component;
a hanger system comprising:
a hanger body comprising an inner bore extending therethrough along an axis;
an inner mandrel comprising an exterior surface comprising a slot, the slot comprising an axially oriented portion that terminates and the slot continues into either an azimuthally oriented portion or a helically oriented portion extending from the axially oriented portion, the inner mandrel being passable from the hanger body inner bore; and
wherein the inner mandrel is movable into a landed position by axial and rotational movement of the inner mandrel relative to the hanger body, the axial and rotational movement being guided by the slot; and
a production tubing string attachable to the inner mandrel and extendable into the well.

US Pat. No. 10,113,383

POSITIVE RETENTION LOCK RING FOR TUBING HANGER

VETCO GRAY, LLC, Houston...

1. A wellhead assembly comprising:a wellhead housing, the wellhead housing having a bore with an axis and an annular lock groove on an inner diameter surface of the bore;
a wellbore member concentrically located within the bore of the wellhead housing defining an annulus between the wellbore member and the wellhead housing, the wellbore member having an upward facing shoulder;
an annular lock ring positioned in the annulus, the annular lock ring having an outer diameter profile for engaging the lock groove and being radially expandable from an unset position to a set position, the set position preventing upward axial movement of the wellbore member relative to the wellhead housing, the lock ring having an inward and upward facing tapered surface;
an energizing ring positioned in the annulus above the lock ring, the energizing ring being axially movable from an upper position to a lower position, the energizing ring having an outward and downward facing lower tapered surface that engages the upward facing tapered surface of the lock ring to push the lock ring outward to the set position as the energizing ring moves downward; and
a retainer in selective engagement with the energizing ring, the retainer engaging a top surface of the energizing ring when the energizing ring is in the lower position, retaining the annular lock ring in the set position and limiting axial upward movement of the energizing ring relative to the wellbore member, the retainer engaging a lower upward facing annular shoulder of the energizing ring when the energizing ring is in the upper position, limiting axial movement of the energizing ring via the lower upward facing annular shoulder, and retaining the annular lock ring and the energizing ring with the wellbore member when the annular lock ring is in the unset position.

US Pat. No. 10,113,380

PUMPING SYSTEM DEPLOYMENT USING CABLE

SCHLUMBERGER TECHNOLOGY C...

1. A method for deploying a pumping system, comprising:moving a coiled tubing injector head into position over a wellhead positioned above a wellbore of a well;
routing an electrical cable through the coiled tubing injector head and through a tree assembly positioned above the wellhead;
coupling the electrical cable to an electric submersible pumping system beneath the coiled tubing injector head; and
using the coiled tubing injector head to deploy the electrical cable and to thus lower the electric submersible pumping system downhole into the wellbore beneath the wellhead without coiled tubing; and
wherein moving comprises coupling the coiled tubing injector head to an adjustable system located adjacent the wellhead, wherein the adjustable system is configured to selectively lift or lower the coiled tubing injector head and the tree assembly relative to the wellhead.

US Pat. No. 10,113,376

CONVEYOR APPARATUS

Stimline AS, Kristiansan...

1. A conveyor apparatus to enable feeding of a continuous elongate device down through the conveyor apparatus to enable insertion of tools through a wellhead and a well below or up through the conveyor apparatus by pulling action enabling retrieval of the tool from the wellhead and the well below, the conveyor apparatus comprising:an apparatus frame;
a pair oppositely located, co-operatively movable, segmented continuous belts installed in the apparatus frame, each belt comprising a plurality of interconnected device gripper shoe carriers carried and movable via a pair of continuous belt drive chains running over respective pairs of chain drive sprockets;
wherein each carrier has a front side and a rear side;
wherein the rear side of the carrier has at least one roller configured to roll about a shaft attached to the carrier against an elongate counter-force member associated with the frame and extending between said drive sprockets;
wherein a device gripper shoe is located at the front side of each carrier; and
wherein the shaft of the at least one roller is resiliently supported transversely of said shaft's longitudinal axis via a plurality of resilient members at spaced apart locations along a length of said shaft, said resilient members being fitted in ears that are arranged at the rear side of the carrier, said resilient members encircling said shaft and providing movability of said shaft relative to said ears.

US Pat. No. 10,113,372

CENTRALIZER

WEATHERFORD TECHNOLOGY HO...

14. A centralizer, comprising:a body having a bore therethrough;
a first collar coupled to the body;
a second collar coupled to the body; and
a plurality of bow springs coupled to the first collar and the second collar, wherein a cross-section of the bow springs includes an arcuate outer surface and a flat inner surface.

US Pat. No. 10,113,371

DOWNHOLE CONTROL LINE CONNECTOR

Halliburton Energy Servic...

1. A connector of a wellbore completion, the connector comprising:a housing having a conduit chamber defined therein between a body and a shroud;
a matable connector at least partially disposed within the housing and providing a mating face that faces with respect to the housing so as to angularly engage and mate with an opposing matable connector, the matable connector including one or more communication media disposed within the conduit chamber and extending to the mating face; and
one or more tubular conduits extending helically from the mating face into the conduit chamber and wrapping helically around the body.

US Pat. No. 10,113,369

CUTTING ASSEMBLY FOR A BORING DEVICE

Barbco, Inc., East Canto...

16. A method comprising steps of:providing a cutting assembly comprising a first cutting head and a second cutting head; wherein the second cutting head is spaced a distance rearwardly behind the first cutting head;
providing a pilot tube within an underground pilot hole having a pilot hole diameter; wherein the borehole follows the pilot hole and has a borehole diameter larger than the pilot hole diameter; and
engaging the cutting assembly and the pilot tube in end-to-end relationship;
engaging the pilot tube with a front end of a shaft of the cutting assembly;
placing a bore of the pilot tube in fluid communication with a bore of the shaft;
moving pressurized air through the bore of the pilot tube into the bore of the shaft;
rotating and moving forward the cutting assembly and a casing extending rearwardly from the cutting assembly to cut an underground borehole;
moving the pressurized air from the bore of the shaft through a first air passage formed in the first cutting head and through a second air passage formed in the second cutting head; and subsequently moving the pressurized air into a bore defined in the casing to discharge cuttings created by the first and second cutting heads out of the casing; and
wherein the step of moving pressurized air through the bore of the shaft further comprises creating backpressure in the bore of the shaft.

US Pat. No. 10,113,368

CUTTING ELEMENTS, EARTH-BORING TOOLS INCORPORATING SUCH CUTTING ELEMENTS, AND METHODS OF FORMING SUCH CUTTING ELEMENTS

Baker Hughes Incorporated...

1. A cutting element, comprising:a substrate;
a thermally stable polycrystalline table comprising interbonded grains of a superhard material and interstitial spaces among the interbonded grains of the superhard material, the thermally stable polycrystalline table being at least substantially devoid of catalyst material used to form intergranular bonds among the interbonded grains of the superhard material;
a substrate portion interposed between the thermally stable polycrystalline table and the substrate; and
a metal material attaching the substrate to the substrate portion, the metal material extending from proximate the substrate, through the substrate portion, and partially into the thermally stable polycrystalline table, the metal material exhibiting a melting temperature of less than 1320° C.

US Pat. No. 10,113,367

SLIDE REAMER AND STABILIZER TOOL

Dynomax Drilling Tools In...

1. A method of reaming a wellbore, comprising:moving a downhole tool on a drill string axially through a wellbore without rotation of the drill string, wherein the downhole tool comprises an elongate main body having:
(a) a longitudinal axis;
(b) an outer surface and a central bore; and
(c) a plurality of channels formed into said outer surface, said channels dividing the main body into a plurality of blade sections corresponding in number to the number of channels;
wherein each of at least two of the blade sections has one or more cartridge pockets formed into the outer surface thereof, each cartridge pocket being configured to receive a tool cartridge housing a tool insert such that the tool insert is confined to rotate by a side wall about a rotational axis transverse to, and offset from, the longitudinal axis of the main body, wherein the downhole tool forms a slide reamer and at least one of the tool inserts is a reamer insert having a plurality of cutting elements,
the reamer insert rotating as the downhole tool moves axially through the wellbore drilling fluid is circulated through the elongate main body.

US Pat. No. 10,113,365

DRILL BIT FOR MILLING COMPOSITE PLUGS

HIJET BIT LLC, Norman, O...

1. A roller cone drill bit comprising:a body having a central axis, around which it is to be rotated, and a coupling for connecting the body to a drill string or coiled tubing; and
at least a first and a second roller cone, each of which is mounted for rotation about a bearing axis extending from the body at an angle oblique to the central axis and has a heel portion and an inner portion between the heal portion and central axis, each of the first and second roller cones having surface on which is disposed a plurality of cutting elements, the plurality of cutting elements arranged on a surface in a plurality of rows comprising at least a first row and a second row that are each concentric with the bearing axis, with one of the first and second rows located closer to the central axis than the other;
wherein the first row on the first roller cone is comprised of groups of one more milled steel teeth alternating with groups of one or more cemented metal carbide inserts, wherein each of cemented carbide inserts has a cutting depth that is equal to or greater than each of the plurality of milled steel teeth in the first row.

US Pat. No. 10,113,363

SYSTEM AND RELATED METHODS FOR CONTROL OF A DIRECTIONAL DRILLING OPERATION

APS Technology, Inc., Wa...

18. A method for controlling a direction of a drill bit coupled to a drill string, the method comprising the steps of:causing the drill bit to drill a borehole into the earthen formation along a predetermined drilling direction;
guiding the drill bit with a rotary steerable motor system according to one or more steering parameters toward the predetermined drilling direction during formation of the borehole in response to any determined deviations between an actual drilling direction and the predetermined drilling direction; and
correcting the steering parameters based on one or more operational parameters of the rotary steerable system, wherein the one or more operational parameter is a differential pressure of a pump in the rotary steerable motor system.

US Pat. No. 10,113,361

SAFETY MECHANICAL BARRIER AND SYSTEM FOR ABOVE-GROUND POOL LADDERS

POLYGROUP MACAU LIMITED (...

14. The safety mechanical barrier of claim 1, wherein the at least one attachment mechanism is adapted for releasably attaching the safety mechanical barrier to the first vertical rail of the pool ladder.

US Pat. No. 10,113,360

ROLL-UP WALL TENSIONING

Hall Labs LLC, Provo, UT...

1. A flexible, roll-up wall, comprising:a roller drum having a selectively engageable one-way bearing;
one or more power supplies;
a motor coupled to the drum by a transmission and electrically coupled to at least one of the one or more power supplies;
a flexible, sound-attenuating sheet having a base fabric and a polymer coating surrounding the base fabric, the sheet coupled to the roller drum at a first end of the sheet;
an electromagnet and at least one of a corresponding permanent magnet or ferromagnet;
one or more conductive threads woven into the base fabric extending from the first end of the flexible sheet to a second end of the flexible sheet, at least one of the one or more conductive threads electrically coupled to the electromagnet and at least one of the one or more power supplies;
a force meter; and
a potentiometer electrically coupled between the at least one power source coupled to the electromagnet and the electromagnet, wherein the potentiometer varies the current delivered to the electromagnet based on a force measured by the force meter.

US Pat. No. 10,113,357

DOOR ASSEMBLY

THERMA-TRU CORPORATION, ...

1. A door assembly, comprising:a door frame including a first side section, a second side section, and a sill section;
a door pivotably connected to the door frame by a hinge such that the door is pivotable between an open position and a closed position, the door including a first edge surface and a second edge surface, wherein the second edge surface faces the sill section;
wherein the door further comprises a first rounded corner between the first edge surface and the second edge surface and the door frame further comprises a second rounded corner between the first side section and the sill section;
wherein a door seal is attached to the door along the first edge surface, the rounded corner, and the second edge surface and a frame seal is attached to the door frame along the first side section, the rounded corner, and the sill section;
wherein the door seal includes a first flat surface facing the door, and a first convex curved surface facing away from the door, the first convex curved surface including a first substantially flat and sloped surface, and a first rounded surface joined with the first sloped surface at an apex of the first convex curved surface, and the frame seal includes a second flat surface facing the door frame, and a second convex curved surface facing away from the door frame, the second convex curved surface including a second substantially flat and sloped surface, and a second rounded surface joined with the second sloped surface at an apex of the first convex curved surface, connecting the second flat surface to the second sloped surface; and
wherein, the first sloped surface engages the second sloped surface when the door is in the closed position.

US Pat. No. 10,113,353

HIGH SPEED DOOR

ASSA ABLOY ENTRANCE SYSTE...

1. A high-speed door for closing or opening an opening formed in a wall, the door comprising:a bearing structure to which is attached a flexible curtain and a drive system enabling the curtain to be moved from a closed position into an open position in which the curtain is concertina-folded into a top of the opening, wherein the bearing structure comprises two cross-sectional U-shaped vertical uprights each comprising a web and two flanges extending perpendicularly from opposite ends of the web between which the curtain is folded, each U-shaped vertical upright being formed of a plurality of one-piece upright section pieces, wherein at least one one-piece section piece incorporates at least one cavity oriented in a longitudinal direction of the section piece;
a lintel comprising a plurality of lintel section pieces each incorporating at least one cavity oriented longitudinally, said lintel enclosing a shaft used to operate the flexible curtain; and
an attachment arrangement disposed on at least one of the upright section pieces and configured for fastening a secondary piece thereto, the attachment arrangement comprising:
a respective male attachment portion disposed on each of the flanges on one side of the at least one upright section piece opposite from the web and extending perpendicularly relative to the web along a longitudinal axis of the flange; and
two female attachment portions, each disposed on the web at an opposite side of the at least one upright section piece and each arranged collinear with the longitudinal axis of the respective flange;
wherein the male attachment portions are configured to engage a corresponding female attachment portion of the secondary piece and wherein the female attachment portions are configured to engage a corresponding male attachment portion of the secondary piece, and wherein the secondary piece comprises at least one of a second one-piece upright section piece or a finishing section piece.

US Pat. No. 10,113,350

DOOR STOPPING DEVICE WITH HANDLE

1. A the door stop device comprising:a rope with a top portion and a bottom portion;
a top rope holder;
a connector;
a lockable ring;
a wedged shaped device comprising:
a wedge shaped doorstop portion;
an attachment portion;
at least one fastening means;
wherein the attachment portion is secured to the wedge shaped portion by the fastening means on both sides of the wedge shaped doorstop portion,
wherein the top portion of the rope is secured and configured to the top rope holder in such a manner as to form a loop for hanging or attaching the loop around a door handle,
wherein the bottom portion of the rope is linked to the lockable ring by the connector, and
wherein the lockable ring links to the attachment portion of the wedge shaped device.

US Pat. No. 10,113,349

LOW-NOISE CARRIER ARRANGEMENT

1. A draw-in arrangement (10) comprising a carrier element (31) which is movable back and forth between a fixed park position and an end position, an acceleration and deceleration device (20) with an energy store (81) for drawing the carrier element (31) toward the park position and a pneumatic cylinder-piston unit (61) for decelerating the movement of the carrier element (31) and a carrier (90) which includes a holding recess (95) for accommodating the carrier element (31) and is provided with a stop (91, 92) facing toward the end position and with a carrier surface area (96), and the carrier element (31) has an engagement projection (36) which includes a push surface area (37) which faces away from the park position and which is contactable with the stop (91, 92), whereinthe carrier (90) is provided with a contact layer (97) surrounding at least the carrier surface area (96),
the engagement projection (36) is provided with a carrier element-side delimiting wall layer (51) surrounding the push surface area (37),
both, the wall layer (51) and the contact layer (97), have at least a thickness of 1.5 millimeters, and
both, the wall layer (51) and the contact layer (97), have a mean elasticity modulus at room temperature of between 700 Newton/mm2 and 1600 Newton/mm2.

US Pat. No. 10,113,347

DOOR GUIDE SYSTEM WITH MODULAR THRESHOLD TRACK

ASSA ABLOY ENTRANCE SYSTE...

1. A sliding door comprising:a door panel;
a floor guide;
a pin guide assembly connected with a bottom of the door panel;
a guide shoe connected with the pin guide assembly; and
a lock-stop connected with the floor guide;
wherein the guide shoe includes a concave mating surface, wherein the floor guide includes a rail having a convex mating surface shaped to correspond with the mating surface of the guide shoe, wherein the mating surfaces of the guide shoe and floor guide are in sliding contact with one another, wherein the guide shoe further comprises two beveled surfaces on opposing terminal ends of the guide shoe arranged along a direction of travel of the guide shoe along the rail; and wherein at least one of the beveled surfaces of the guide shoe engages with an engagement surface of the lock-stop to prevent the guide shoe from disengaging from the floor guide, such that when the at least one beveled surface is engaged with the engagement surface at least a portion of the beveled surface is between the engagement surface and the floor guide.

US Pat. No. 10,113,346

HINGE, IN PARTICULAR FOR A PIECE OF FURNITURE

JULIUS BLUM GMBH, Hoechs...

1. A hinge comprising:an inner hinge portion to be fixed to a furniture body or to a furniture door pivotably mounted to the furniture body,
an outer hinge portion to be fixed to an outer door, the inner hinge portion and the outer hinge portion collectively having a lower receiving member, an upper receiving member, and a central receiving member, and
a connecting device slideable in an inserting direction into the lower receiving member, the central receiving member, and the upper receiving member so as to pivotably connect the inner hinge portion to the outer hinge portion,
wherein the inner hinge portion has a main body to be fixed to the furniture body or to the furniture door pivotably mounted to the furniture body, and the lower receiving member is slidable in a sliding direction relative to the upper receiving member mounted to the main body, the sliding direction being transverse to the inserting direction of the connecting device.

US Pat. No. 10,113,342

LATCH ASSEMBLY

INTEVA PRODUCTS, LLC, Tr...

1. A latch assembly, comprising:a chassis;
a latch bolt, movably mounted to the chassis for movement between a closed position for retaining a striker in the latch assembly and an open position for releasing the striker from the latch assembly;
a pawl rotatably mounted to the latch assembly via a pawl pivot pin for rotation between an engaged position wherein the pawl retains the latch bolt in the closed position and a disengaged position wherein the pawl is disengaged from the latch holt such that the latch can move to the open position; and
wherein the pawl rotates about and contacts a surface of the pawl pivot pin, the surface of the pawl pivot pin including a first arcuate portion and a second arcuate portion, wherein a radius of the first arcuate portion is smaller than a radius of the second arcuate portion such that friction between the pawl and the pawl pivot pin is reduced during rotation of the pawl about the pawl pivot pin.

US Pat. No. 10,113,341

MOTOR VEHICLE LOCK WITH A POSITION SECURING SYSTEM

Kiekert Aktiengesellschaf...

1. A latch with a locking mechanism that includes a catch and a pawl for locking the catch and optionally including an anti-theft device, the latch comprising:a position securing system comprising:
an actuating lever coupled to one of the locking mechanisms or the anti-theft device;
a pin movable between a first position where either the locking mechanism or anti-theft device is locked and a second position when either the locking mechanism or anti-theft device is unlocked, wherein the pin is coupled to the actuating lever;
a pincer spring with a first spring leg and a second spring leg that act on opposite sides of the pin, wherein the pincer spring resists moving the pin between the first and second positions; and
a housing comprising a first wall and a second wall that act as stops which limit the movement of the first and second spring legs caused by moving the pin between the first and second positions, wherein the first leg spring has a first free end and the second leg spring has a second free end, wherein the free ends are fixed to the housing.

US Pat. No. 10,113,340

TELL-TALE INDICATOR FOR LOCATING A SECONDARY HOOD LATCH RELEASE

GM Global Technology Oper...

1. An apparatus for aiding an operator having a finger in locating and operating a secondary hood latch release of a secondary hood latch in a gap between a vehicle body and an openable hood having an outer surface, the apparatus comprising:an indicator located directly above the secondary hood latch release and on the outer surface of the openable hood, and configured to display a location of the secondary hood latch release such that the secondary hood latch release is readily locatable and operable by the operator to open the hood:
wherein the secondary hood latch release is operable by reaching into the gap between the body and the openable hood with the finger and applying an operating force in an operating direction to the secondary hood latch release.

US Pat. No. 10,113,339

FUEL DOOR ACTUATOR

Kiekert AG, Heiligenhaus...

1. An actuator for a fuel tank cap in a vehicle comprising:a latch for locking the fuel tank cap;
an electric drive to enable an automatic opening and closing cycle of the fuel tank cap;
a control plate rotatable by the electric drive and having a control contour;
a torque plate having a torque contour that interacts with the control contour by direct contact for transmitting a force and motion to the torque plate, wherein the transmission of force and motion depends on a rotation position of the control plate; and
a mating plate having a mating contour that interacts with the control contour by direct contact, whereby the torque plate transmits the force and motion from the control plate to the mating plate,
wherein the control plate, the torque plate and the mating plate are arranged along a longitudinal axis of rotation of the electric drive or the fuel tank cap.

US Pat. No. 10,113,336

ORIFICE FLOWMETER SECURITY DEVICE

Daniel Measurement and Co...

1. A security device for use with an orifice flowmeter and a locking device, the security device comprising: a housing having a top surface, a bottom surface, a closed end, an open end, a front surface, and a back surface forming a cavity, and a first protrusion disposed in the cavity on an interior side of one of the top surface or the bottom surface, the first protrusion further disposed between the front surface and the flowmeter when the security device is secured to the flowmeter; wherein the cavity is exposed at the open end and the back surface, which comprises a cutout forming an upper back surface portion and a lower back surface portion, the upper back surface portion and the lower back surface portion configured to slidingly and releasably engage a gap formed between a nut and a body of the flowmeter when the security device is secured to the flowmeter; wherein the top surface includes a through bore that is coaxial with a through bore of the bottom surface proximate the open end; wherein the top surface through bore and the bottom surface through bore are configured to allow a rod to pass therethrough thereby preventing removal of the security device from the flowmeter; wherein the first protrusion comprises a pair of side walls extending from the closed end of the housing and a channel disposed between the pair of side walls.

US Pat. No. 10,113,331

VEHICLE PANEL HANDLE FOR OPENING A PANEL OF AN AUTOMOTIVE VEHICLE

VALEO S.P.A., Santena (I...

1. A vehicle panel handle for opening a panel of an automotive vehicle comprising:a handle lever configured to rotate around a first rotation axis between a resting position wherein the panel is closed and an opening position wherein the panel is open, the first rotation axis being perpendicular to a pivotal plane of the handle lever;
a latch lever configured to rotate around a second rotation axis and to cooperate with the handle lever for opening the panel when the handle lever rotates around the first rotation axis for reaching the opening position, the second rotation axis intersecting the pivotal plane of the handle lever and defines a first vector from the second rotation axis to the first rotation axis;
a counter weight configured for preventing the unwilling rotation of the handle lever, the counter weight is configured to rotate around a third rotation axis between an unblocking position wherein the latch lever is not prevented from rotating, and a blocking position wherein the latch lever is preventing from rotating, the counterweight comprising an elongated body having one end defining the third rotation axis and an opposed end having a weight portion, wherein the weight portion is located between the first rotation axis and the second rotation axis, the third rotation axis intersecting the pivotal plane of the handle lever and defines a second vector from the second rotation axis to the third rotation axis; and
an extension of the handle lever disposed between the second rotation axis and the third rotation axis along a longitudinal direction that is substantially orthogonal to the second vector, wherein the extension of the handle lever is configured to cooperate with a recess or protrusion of the latch lever to rotate the latch lever,
wherein the second rotation axis is disposed between the first rotation axis and the third rotation axis such that the first vector and the second vector form an obtuse angle.

US Pat. No. 10,113,330

EXPANDABLE MAT-BASED SUN SHELTER

Imam Abdulrahman Bin Fais...

1. A collapsible sun shelter, comprising:a single transverse arch support, and
rollable flat mat,
wherein the rollable flat mat is configured to expand to include a canopy section having a spiral-like pattern,
wherein the rollable flat mat comprises a floor area portion, an upwardly deployable area portion, at least two mat anchor points and at least two arch support openings,
wherein the upwardly deployable area portion is defined by an outer perimeter passing through at least one layer of the rollable flat mat such that the upwardly deployable area portion remains connected with the floor area portion when the upwardly deployable area portion is extended upwardly in a deployed configuration,
wherein the upwardly deployable area portion of the canopy section comprises at least one point of contact and/or point of attachment with the single transverse arch support.

US Pat. No. 10,113,327

SECTION OF CONCRETE

LAFARGE, Paris (FR)

1. A section of concrete adapted to form a mast of a windmill, said section of concrete defining an internal volume, said section of concrete having an outer face and an internal face opposite the outer face, said internal face arranged facing the internal volume, said section of concrete comprising:a first portion arranged to exert a bearing force on a lower adjacent part of the windmill, said first portion comprising a first flange extending in the internal volume substantially transversely from the internal face of the section of concrete,
a second portion arranged to form a bearing support for an upper adjacent part of the windmill, said second portion comprising a second flange extending in the internal volume substantially transversely from the internal face of the section of concrete,
a prestressing device arranged to apply a stress between the first portion of the section of concrete and the second portion of the section of concrete, said prestressing device comprising at least one part extending outside the section of concrete and within the internal volume, said part located between the first flange of the first portion of the section of concrete and the second flange of the second portion of the section of concrete,
a first attaching device arranged to be connected to the first flange and arranged to be used to attach the section of concrete on the lower adjacent part of the windmill, and/or
a second attaching device arranged to be connected to the second flange and arranged to be used to attach the section of concrete to the upper adjacent part of the windmill.

US Pat. No. 10,113,325

GENERATOR ENCLOSURE SYSTEM

Kohler Co., Kohler, WI (...

1. A generator enclosure system comprising:a base supporting a generator;
a first support element connected to the base and including a front and a back, wherein the front includes a locking bolt;
a second support element connected to the base;
a front panel removably connected to the first support element by a locking mechanism including a lever, wherein the locking mechanism is configured to interact with the locking bolt to lock the front panel to the first support element;
a back panel configured to attach to the first support element, the second support element, or the first support element and the second support element;
a first side panel removably connected to a connecting element of the front panel on a first side of the generator enclosure system; anda second side panel removably connected to a connecting element of the front panel on a second side of the generator enclosure system, wherein the first support element and the second support element define a first chamber, a second chamber, and a third chamber, the third chamber being for ventilation within the generator enclosure system.

US Pat. No. 10,113,324

RE-POSITIONABLE FLOOR GUIDE SYSTEM AND TOOL FOR USE IN THE SAME

ISCHEBECK TITAN LIMITED, ...

1. A floor guide system, comprising:a floor guide, comprising a mounting arm extending along a longitudinal axis and a floor guide fixing means for fixing said mounting arm to a floor of a construction, said floor guide fixing means having a fixed guide-to-floor configuration and a released guide-to-floor configuration, said floor guide being slidable along said floor in said released guide-to-floor configuration; and
a tool comprising:
a first member fixable to the floor of the construction at a first position along an axial length of the mounting arm;
a tool fixing means for fixing said first member to the floor of the construction at said first position along said axial length of the mounting arm, said tool fixing means having a fixed tool-to-floor configuration and a released tool-to-floor configuration, wherein said floor guide fixing means is in said released guide-to-floor configuration when said tool fixing means is in said fixed tool-to-floor configuration;
a second member fixable to the mounting arm at a second position spaced along said longitudinal axis of the mounting arm from the first member; and
a driving means linking the first and second members to one another, wherein space between the first and second members along the longitudinal axis is set by said driving means,
wherein said floor guide is slidable along said floor according to said second member and said driving means when said floor guide fixing means is in said released guide-to-floor configuration when said tool fixing means is in said fixed tool-to-floor configuration,
wherein the first member comprises a U-shaped bracket having an upper portion spanning a width of said mounting arm and a pair of vertical leg portions extending downward from said upper portion and along sides of said mounting arm so as to form respective lower regions to engage said floor of said construction.

US Pat. No. 10,113,318

FLOOR PANEL FOR FORMING AND ENHANCED JOINT

FLOORING INDUSTRIES LIMIT...

1. A floor panel having a thickness and a centerline, the thickness defined between an uppermost and a lowermost surface of the floor panel, the centerline located at a middle of the thickness of the floor panel, the floor panel which, at least at two opposite edges is provided with profiled edge regions, which, comprise coupling parts substantially comprising a tongue and a groove, the groove being bordered in an upward direction by an upper lip and in a downward direction by a first portion of a lower lip, the lower lip having a second portion projecting distally from said first portion of the lower lip, wherein said coupling parts in coupled condition of two of such floor panels effect a locking in vertical direction, and wherein the profiled edge regions further comprise locking parts, which, in a coupled condition of two of such floor panels, effect a locking in a horizontal direction, wherein at least one of the aforementioned locking parts is provided at the tongue,wherein said groove is bordered by said lower lip, as well as by the upper lip, and that the lower lip distally extends beyond the upper lip, and
a length of the second portion of the lower lip that distally extends beyond the upper lip, measured in horizontal direction, is smaller than the thickness of the floor panel, and
wherein said coupling parts and locking parts are arranged such that they allow that two floor panels are laterally interconnected or coupled by coupling by turning the floor panels into each other along their edges, and
wherein a space is defined in front of the tongue, and extends from an innermost area of the groove at least to a tip of the tongue, the space being completely situated above the center line of the floor panel;
wherein the space continues to a contact surface between the tongue and the groove, and the space over its entire extension is located completely above the center line.

US Pat. No. 10,113,315

DEBRIS EXCLUSION DEVICE FOR RAIN GUTTERS

1. A gutter protection device that allows for removal and installation of multiple filter types, the device comprising:a. a frame, the frame including;
i. an upper filter capture channel; and
ii. a lower filter capture channel;
iii. a collection channel that separates the upper filter capture channel and the lower filter capture channel;
iv. a multiplicity of drain holes within the collection channel;
b. a stiffening rib formed within the collection channel to cause water to be emptied into the center of a gutter;
c. a plurality of drain penetrations within an upper face of the stiffening rib, the plurality of drain penetrations facing the upper filter capture channel;
d. a filter;
i. the filter retained within the device by the upper filter capture channel and the lower filter capture channel of the frame.

US Pat. No. 10,113,312

PANEL FIXING ASSEMBLY

AUTEX INDUSTRIES LIMITED,...

1. A connector for connecting a panel member to an overhead support structure or cross support member, the connector including an elongate planar body with a first planar surface and second planar surface separated by a thickness dimension, having side edges and end edges whereby the side edges define a longitudinal direction parallel with the side edges' length and the end edges define a transverse direction, the side and end edges being in a horizontal plane, the elongate planar body includes a first end portion and a second end portion separated by a middle portion, the first end portion comprises an enlarged partially rounded shape, wherein the first end portion is a fixing portion and the second end portion is a locating portion, the fixing portion includes fixing means to removably affix the connector to a panel capping member or overhead support structure, wherein the fixing portion includes a first camming body extending outwardly at a right angle to the longitudinal direction in a vertical direction from the first planar surface and the camming body includes a base portion extending in the same direction as the first camming body from the end portion, leading to a platform portion being spaced from the first planar surface of the elongate planar body forming at least one recessed gap for the locating of camming surfaces, and the fixing portion also includes a further fixing means to affix the connector to the overhead support structure or panel capping member, the further fixing means including a second camming body extending outwardly at a right angle to the longitudinal direction in a vertical direction opposite from the direction the first camming body extends from the second planar surface and the second camming body includes a base portion extending in a direction opposite to the first camming body from the end portion, leading to a platform portion being spaced from the second planar surface of the elongate planar body forming at least one recessed gap for the locating of the camming surfaces.

US Pat. No. 10,113,311

WALL ASSEMBLY

2. A double sided retaining wall or freestanding wall, comprisinga trellis panel having front and back sides, lateral ends and a top end;
a support for maintaining the trellis panel in an upright orientation;
a plurality of first facing blocks stacked into a first facing wall on one of the front and back sides of the trellis panel;
a plurality of second facing blocks stacked into a second facing wall on the other of the front and back sides of the trellis panel; and
a plurality of connectors, a rear surface of each of the first and second facing blocks being connected to the trellis panel in the stacked condition by a spaced apart pair of the connectors for maintaining the first and second facing walls upright;
each connector extending either between one stacked first facing block and the one of the front and back sides of the trellis panel to connect the first facing wall only to the trellis panel, or between one stacked second facing block and the other one of the front and back sides of the trellis panel to connect the second facing wall only to the trellis panel and for allowing shifting of the stacked first and second facing blocks within the first and second facing walls; and
wherein:
the first and second facing blocks are different in at least one of size, shape and orientation, and
the first and second facing blocks have a rear surface and a retaining recess in the rear surface for engagement by one of the connectors and at least one of a location and orientation of the retaining recesses in the stacked first facing blocks of the first facing wall differs from that of the retaining recesses in the stacked second facing blocks of the second facing wall.

US Pat. No. 10,113,308

EXPANSION JOINTS

Underwood Companies Holdi...

1. An expansion joint applied to a layer applied to a substrate, the joint having a first strip extending on one side of the joint and a second strip extending on the other side of the joint, an upper surface plate of the first strip being adapted to extend across the joint, and being disposed to move across the joint, the strips being mutually aligned for relative movement while maintaining the upper surface of the first strip in a predetermined plane relative to the second strip;wherein the first and second strips comprise mutually aligned male and female cooperating parts, the male part comprising a male strip, the female part carrying the upper surface plate and comprises a channel extending along the first strip and the joint includes one or more seals between the strips and a seal receiving formations adapted to retain said one or more seal, said formation comprising tapered edge rebates of opposite corners of a free edge of the male strip and holding a matching seal strip scaling the first and second strips.

US Pat. No. 10,113,306

DECK BOARD FASTENERS

SIMPSON STRONG-TIE COMPAN...

1. A decking clip comprising:a body having a transverse upper member with an upper surface and a lower surface, a perpendicular member extending from the lower surface of the upper member, a central aperture through the transverse upper member, two or more clip anchor apertures positioned about the central aperture, and a planar surface section on the upper surface of the transverse upper member between the central aperture and the two or more clip anchor apertures; and
a clip having an upper surface and a lower surface, a central clip aperture therethrough, and two or more clip anchors positioned along at least one edge of the clip and extending downward away from the lower surface of the clip, wherein the clip anchor apertures receive the clip anchors when the central aperture of the transverse upper member corresponds at least partially with the central clip aperture and the lower surface of the clip engages the planar surface section of the upper surface of the transverse upper member.

US Pat. No. 10,113,297

BACK GUARD ATTACHABLE TO A BUCKET, METHOD OF FORMING THE BACK GUARD, AND BUCKET ASSEMBLY INCLUDING THE BACK GUARD

R2 MANUFACTURING LLC, Po...

1. A back guard attachable to a bucket, the back guard comprising:a left support attachable to a left side of the bucket;
a right support attachable to a right side of the bucket;
a back support connectable to the left support and the right support, the back support extending upwardly from a rear side of the bucket, in a state where the back guard is attached to the bucket; and
an adjustment mechanism that permits the back support to accommodate different buckets having different widths,
wherein the left support includes a left side post and a first left bar that extends from the left side post laterally toward the right side of the bucket, in the state where the back guard is attached to the bucket,
wherein the right support includes a right side post and a first right bar that extends from the right side post laterally toward the left side of the bucket, in the state where the back guard is attached to the bucket,
wherein the back support includes a first bar and a support plate fixed to the first bar, the support plate and the first bar extending between the left side post and the right side post, in the state where the back guard is attached to the bucket, and
wherein the adjustment mechanism includes the first left bar and the first bar that are slideably arranged from a left side of the back support, and the first right bar and the first bar that are slideably arranged from a right side of the back support, in the state where the back guard is attached to the bucket, to allow the back support to accommodate buckets having different widths,
wherein the back support is:
laterally displaceable relative to the left and right side posts, and
anchored to at least one of the first left or right bar, in the state where the back guard is attached to the bucket to prevent the back support from laterally displacing relative to the left and right supports during use.

US Pat. No. 10,113,294

MODULAR DESIGN FOR A DIPPER DOOR AND IMPROVED LATCH LEVER BAR

Caterpillar Inc., Deerfi...

1. A latch lever bar for use with a latching mechanism of a dipper door that includes a latch bar that includes a yoke, the latch lever bar comprising:an interface portion that includes a straight surface that is configured to contact the yoke of a latch bar; and
a pivot connecting portion that is configured to pivotally connect the latch lever bar to the door, wherein the pivot connecting portion defines a pivot point that is collinear with the straight surface of the interface portion;
the latch lever bar comprises a body that defines an X and a Y direction, and a X-Z plane; wherein the latch lever bar comprises a top protrusion that extends from the body a distance measured in the Y direction;
the body of the latch lever bar defines a bottommost edge adjacent the yoke interface portion along the X direction and a recess with an apex that extends from the bottommost edge along the X direction, the body further comprising a bottom protrusion that extends from the body a distance measured in the negative Y direction such that the bottom surface of the bottom protrusion is flush with the bottommost edge in a plane parallel to the X-Z plane containing the bottommost edge, defining a distance between the apex of the recess and the bottommost edge measured in the Y direction;
the distance between the apex of the recess and the bottommost edge is less than the distance that the top protrusion extends from the body of the latch lever bar;
the bottom protrusion includes a plateau and the top protrusion includes a right sloping surface that is configured to be a stop surface.

US Pat. No. 10,113,291

SUMP SYSTEM WITH OVERFLOW PROTECTION

STATE FARM MUTUAL AUTOMOB...

1. A method of protecting a sump system from overflow during intense rainfall events, wherein the sump system includes a drain line having a discharge orifice leading into a sump pit and hydraulically coupled to a water drainage system to transfer water from the water drainage system into the sump pit, and a water removal system arranged to remove water from the sump pit, the method including:installing a flow restrictor along the drain line, wherein the flow restrictor is sized and arranged to restrict the total maximum flow capacity of the drain line into the sump pit to match the maximum capacity output flow rate of the water removal system, and wherein the flow restrictor does not completely shut off or prevent flow of water through the drain line and thereby does not form a dead head of water within the drain line.

US Pat. No. 10,113,288

CONCRETING FACILITY AND CORRESPONDING CONCRETING METHOD

SOLETANCHE FREYSSINET, R...

1. A method of concreting an excavation, the method comprising:placing a concreting column in the excavation for concreting, wherein the concreting column extends between an open top end and a bottom end thereof;
at least partially filing the concrete column with a fluid other than concrete; and
performing a first concreting cycle, wherein the first concreting cycle comprises a priming step comprising:
inserting concrete into the concreting column via the open top end to expel the fluid other than concrete from the concreting column;
filing the concreting column with concrete; and
retaining a volume of concrete a distance from the open top end such that a height of an empty space, defined between the volume of concrete and one of the open top end and the bottom end of the concreting column, remains less than a predetermined limit value, wherein retaining the volume of concrete comprises at least partially constricting a flow section inside the concreting column and/or to the outside of the concreting column.

US Pat. No. 10,113,285

REVETMENT SYSTEM

Shoretec, LLC, Baton Rou...

1. A multi-layer revelment system adapted to be placed on top of a ground surface to inhibit its erosion, comprising:a cellular confinement layer comprising a matrix of rigid wall cells that are open across the height of the cells, wherein the height of the cells is about 1 to 12 inches,
an articulated block layer adapted to be placed on top of the cellular confinement layer on the opposite side of the cellular confinement layer than the ground surface, and
a permeable geosynthetic layer that is adapted to be placed on the ground surface and under the cellular confinement layer;
and wherein none of the layers are fixed to an adjacent layer.

US Pat. No. 10,113,283

SNOW DISCHARGE DIVERTER APPARATUS AND METHOD

1. An apparatus for snow removal diversion, comprising:a snow discharge diverter configured to change a flow of discharged snow from a snow removal vehicle connected thereto, said snow discharge diverter selectably movable between at least a snow discharging diverter position and a snow pushing diverter position, the snow discharging diverter position arranged to direct the flow of discharged snow to at least one side of a path of the snow removal vehicle, the snow pushing diverter position arranged to cause the flow of discharged snow to cumulate in a leading front side of the snow discharge diverter in a snow pushing position relative to the path of the snow removal vehicle;
a location detector antenna mounted on the snow removal vehicle at an offset distance from the snow discharge diverter;
a location detector operatively coupled to the location detector antenna to read an antenna location of the location detector antenna;
a predefined areas memory storing a list of a plurality of predefined areas for avoiding discharging snow, said list comprising a starting point location and an ending point location of each of the areas; and
a controller operatively coupled to the location detector, the predefined areas memory, and the snow discharge diverter and configured to control a position of the snow discharge diverter among the snow discharging diverter position and the snow pushing diverter position based on the antenna location and the list of the plurality of predefined areas for avoiding discharging snow, wherein the controller is constructed and arranged to:
(a) receive a first signal from the location detector, said first signal comprising updated location data of the location detector antenna;
(b) receive a second signal from the memory, said second signal comprising the location data of the plurality of predefined areas;
(c) calculate an activation distance from the location detector antenna to the start of each of the plurality of predefined areas said calculation using the antenna location and using a current snow removal vehicle speed and using the starting point location and the ending point location of the predefined areas;
(d) transmit an activation signal to the snow discharge diverter to cause the snow discharge diverter to change to the snow pushing diverter position when the antenna location is within the activation distance of any one of the predefined areas;
(e) calculate a deactivation distance from the antenna location to the ending point location of each of the plurality of predefined areas said calculation based on at least the antenna location, the current snow removal vehicle speed, and the ending point location of the predefined areas; and
(f) transmit a deactivation signal to the snow discharge diverter to cause the snow discharge diverter to change to the snow discharging diverter position when the antenna location is within the deactivation distance of the ending point location of any one of the areas;
wherein the apparatus further comprises a snow removal auger; and wherein the diverter comprises a snow discharge chute operatively coupled to the snow removal auger.

US Pat. No. 10,113,282

CUTTING EDGE ATTACHMENT FOR SNOW PLOW

Nordic Auto Plow LLC, We...

1. A snow plow blade attachment and mounting for use with an existing plow blade mold board with a set of holes, comprising:a traditional cutting blade with a hole pattern and with a bottom part having a lower edge for engaging a ground;
a reinforcing plate with the hole pattern;
and a rounded cutting edge snow blade attachment having a first upper vertical flat thin section of a thickness with pre-drilled holes that match the hole pattern to receive the reinforcing plate on one side and the traditional cutting blade on the other side to secure the blade attachment to the traditional cutting blade, further including integral and adjacent to the first upper vertical flat thin section a second lower thin section of the first thickness separated from the first upper vertical flat thin section by a horizontal bend of approximately 30 to 45 degrees from the vertical and wherein the second lower thin section includes a primary curved section forming a rounded portion that protrudes forward of the first upper vertical flat thin section and bends downward to pass below the lower edge of the bottom part of the traditional cutting blade in a secondary flat and horizontal section.

US Pat. No. 10,113,281

SNOWTHROWER IMPELLER ASSEMBLY WITH RIGID CUTTING IMPLEMENT

1. An impeller assembly for a snowthrower, comprising:a driven shaft configured to rotate about an axis;
a flexible impeller extending horizontally across substantially a complete width of the impeller assembly along the axis and configured to rotate about the axis, wherein the flexible impeller extends radially from the driven shaft to an impeller radial distance; and
a rigid cutting implement extending radially from the driven shaft to a cutting implement radial distance less than the impeller radial distance, wherein the rigid cutting implement is spaced apart from and does not contact the flexible impeller.

US Pat. No. 10,113,279

BARRIER SYSTEMS WITH PROGRAMMABLE LIGHT ASSEMBLY

Off The Wall Products, LL...

1. A method for using barrier systems, the method comprising:positioning a plurality of barrier systems at a location, each barrier system comprising:
a barrier having an interior surface and an opposing exterior surface, the interior surface bounding a chamber that is adapted to receive a ballast; and
a light assembly secured to the barrier, the light assembly comprising a housing having a lens that at least partially bounds a compartment, a light emitting device at least partially disposed within the compartment, and programmable circuity in electrical communication with the light emitting device;
communicating wirelessly with the programmable circuity of each barrier system through a control device after the barrier systems are positioned at the location so that data is transferred between the control device and the programmable circuity of each barrier system,
wherein the programmable circuity of each light assembly transfers data to the control device, the data comprising a temperature reading at each light assembly or an operational condition of each light assembly.

US Pat. No. 10,113,275

SELF-PROPELLED GROUND MILLING MACHINE AND METHOD FOR WORKING ON A TRAFFIC SURFACE

Wirtgen GmbH, (DE)

1. A method for working a traffic surface using a self-propelled ground milling machine, wherein the machine comprises a working roller arranged in a roller housing, a hold-down device which is height-adjustable with respect to the traffic surface being arranged upstream of the working roller in a working direction, and one or more sensors, the method comprising:detecting, via the one or more sensors, a physical variable characteristic of disruption to an operating process, wherein a compressive force is applied counter to a force exerted by a weight of the hold-down device by fragments broken off from the traffic surface; and
upon detecting the disruption to the operating process, automatically applying a contact pressure to the hold-down device, said contact pressure directed counter to the compressive force applied by the fragments.

US Pat. No. 10,113,274

ROAD FINISHER WITH HEATED TAMPER BAR

BOMAG GMBH, Boppard (DE)...

1. A road finisher, comprising:a screed plate extending at right angles to the working direction of the road finisher; and
a tamper bar disposed rearwardly and/or forwardly of the screed plate in the working direction, wherein at least one electrically operated heating element is present, which is configured to heat up a heating surface facing a road subsurface, and wherein the heating element comprises a heating layer at least partially comprising a thermal spray coating obtained through thermal spraying onto a substrate surface, wherein the tamper bar is made from two parts with an upper tamper bar member and a lower tamper bar member assembled together;
wherein the upper tamper bar member has a lower surface which, in the assembled state, contacts an upper surface of the lower tamper bar member, wherein a groove is provided in the lower surface of the upper tamper bar member; and
wherein the heating layer, which is multilayered comprising at least an insulating layer, a strip conductor, and a sealing layer, is accommodated in the groove.

US Pat. No. 10,113,272

FISHPLATE COMPRISING A PROTECTIVE STRIP

1. A lateral fishplate (21, 22) for isolating a railway rail (1), including a buried rail, wherein an upper face of said fishplate comprises a protective strip (26), formed of a wire mesh (32) and of a sheet (31) glued to one another.

US Pat. No. 10,113,265

LAUNDRY SOCK/GARMENT SNARE

Laundry Loops, Inc., Boz...

1. A laundry snare for laundering a plurality of items, the laundry snare comprising:two elongated cord strands having:
a first end wherein the two cord strands are connected together; and
a second end wherein the two cord strands are connected together;
a plurality of loading regions located between the first and second ends formed by a plurality of stoppers positioned along a length of the two cord strands and securing the two cord strands together; and
a plurality of releasable cordlock fasteners placed between two of the plurality of stoppers and configured to be selectively located and secured between the two of the plurality of stoppers;
wherein the releasable cordlock fasteners are threaded through the two cord strands.

US Pat. No. 10,113,261

FABRIC TREATING APPARATUS

LG Electronics Inc., Seo...

1. A fabric treating apparatus comprising:a casing that comprises:
a treating chamber that is configured to receive clothes; and
a machinery room that is located below the treating chamber;
a base that is located at a bottom of the machinery room;
a heat pump module that is configured to condition air supplied to the treating chamber;
at least one supporter (a) that includes a shelf (i) that is supported by legs that are fixed to the base and (ii) that supports the heat pump module and that defines a space (i) between the base and the heat pump module and (ii) below the shelf and (b) that includes a first supporter fixing tab that includes a surface that faces the base and that is located at a lower part of at least one of the legs;
a steam generating module that is located in the space and that is configured to generate steam and supply steam to the treating chamber; and
a controller that is configured to control at least one of the heat pump module or the steam generating module, the controller being located in the space and below the steam generating module,
wherein the base includes a first supporter fixing part that includes a first supporter fastening hole that is configured to receive the first supporter fixing tab.

US Pat. No. 10,113,259

FLANGE STRUCTURE AT BOTTOM OF INNER TUB OF WASHING MACHINE AND A WASHING MACHINE

QINGDAO HAIER WASHING MAC...

1. A flange structure for use at a bottom of an inner tub of a washing machine, comprisinga shaft joint portion located at a center of the flange,
an annular mounting portion configured to be fixedly connected with the bottom of the inner tub of the washing machine and located at an outer periphery of the shaft joint portion,
a plurality of connecting portions provided between the mounting portion and the shaft joint portion, each connecting portion including a main rib extending from the mounting portion to the shaft joint portion, and
a plurality of transverse ribs arranged on both sides of the main rib in an extending direction of the main rib respectively in turn,
wherein the connecting portions descend from the main rib towards both sides in an extending direction of the transverse ribs,
a V-shaped recess is formed between two adjacent connecting portions, and a V-shaped recess bottom end is a breach of the flange formed by a distance between the transverse ribs of the two main ribs for water flow,
and wherein a filter portion is formed in a region between the mounting portion and the shaft joint portion by the plurality of connecting portions.

US Pat. No. 10,113,256

EMBROIDERY CONVERSION DEVICE FOR EMBROIDERY SEWING MACHINE, EMBROIDERY CONVERSION METHOD FOR EMBROIDERY SEWING MACHINE, AND RECORDING MEDIUM STORING EMBROIDERY CONVERSION PROGRAM FOR EMBROIDERY SEWING MACHINE

Janome Sewing Machine Co....

1. An embroidery conversion device for an embroidery sewing machine having embroidery monotone color display data and embroidery data for each of embroidery areas, and capable of performing conversion for forming embroidery in a given embroidery color by selecting embroidery areas that are displayed to specify a color for the areas, and by having the color specification for the embroidery areas and embroidery data for the selected embroidery areas be recorded, the device comprising:a base-color setting unit that sets a base color used in monotone embroidery in which embroidery is formed in shades of one color entirely over the embroidery areas;
a gradation-data generating unit that generates gradation data expressing shading for monotone embroidery, based on an embroidery color specified for each of the embroidery areas;
a gradation shade-number setting unit that allows a user to set a number of shades in gradation for monotone embroidery to be used in execution of monotone embroidery, within a limit determined based on a multicolor embroidery pattern to which a plurality of color threads are assigned;
a gradation-data converting unit that converts the gradation data generated by the gradation-data generating unit into working gradation data of the number of shades in gradation set by the gradation shade-number setting unit, and to set the working gradation data as the embroidery monotone color display data;
a recording unit that collectively records the embroidery monotone color display data specified for each of the embroidery areas and embroidery stitch data; and
a control unit that controls the embroidery sewing machine to perform an embroidery operation of a monotone color image with gradation as an entire image converted from a multicolor image, based on the embroidery monotone color display data.

US Pat. No. 10,113,253

METHOD AND APPARATUS FOR FABRICATING SUSCEPTOR COIL ASSEMBLIES

The Boeing Company, Chic...

1. An apparatus for fabricating a susceptor coil assembly, the apparatus comprising:a tensioning section;
a feeding section configured for feeding a conductor wire toward the tensioning section, the tensioning section being configured for maintaining a desired tension of the conductor wire; and
a coiling section configured for winding a susceptor wire around an outer surface of the conductor wire so as to fabricate a susceptor coil assembly as the conductor wire moves from the feeding section toward the tensioning section, the coiling section comprising a winder head comprising:
a first wire inlet configured for receiving the conductor wire from the feeding section; and
a second wire inlet that extends radially from the first wire inlet and is configured for radially receiving the susceptor wire as the coiling section winds the susceptor wire and for receiving the conductor wire as the conductor wire moves toward the tensioning section.

US Pat. No. 10,113,249

SILICON CARBIDE SUBSTRATE AND METHOD FOR MANUFACTURING THE SAME

Sumitomo Electric Industr...

1. A silicon carbide substrate having a main surface,the main surface having a surface roughness (Ra) of less than or equal to 0.1 nm, and
vanadium, tungsten, molybdenum, platinum, nickel, titanium, zirconium, and chromium each having a concentration of less than or equal to 1.0×1012 atoms/cm2 in the main surface,
wherein vanadium has a concentration of more than or equal to 1.0×106 atoms/cm2 in the main surface.

US Pat. No. 10,113,244

METHOD AND APPARATUS FOR UNIFORMLY METALLIZATION ON SUBSTRATE

ACM Research (Shanghai) I...

1. An apparatus for substrate metallization from electrolyte comprising:an immersion bath containing metal salt electrolyte;
at least one set of electrodes connecting to at least one power supply;
a substrate holder holding at least one substrate to expose a conductive side of the substrate to face one set of electrode, the substrate holder being electricity conducting;
at least one sonic device coupled with a reflection plate for forming an ultra or mega sonic standing wave area in the immersion bath;
a first oscillating actuator oscillating the substrate holder along its axis for making the substrate holder pass through the entire ultra or mega sonic standing wave area with different sonic power intensity, so as to result in an uniformed sonic energy dose distribution across the substrate held by the substrate holder in an accumulated time; and
an adjusting mechanism for adjusting one of the reflection plate and the sonic device to be parallel to the other, wherein the adjusting mechanism includes an actuator for oscillating the reflection plate or the sonic device along the propagating direction of the ultra or mega sonic standing wave, wherein the oscillation amplitude is equal to N time of half wave length of the ultra or mega sonic standing wave, and N is an integer number from 1 to 10.

US Pat. No. 10,113,243

MANUFACTURING METHOD OF CASING OF ELECTRONIC DEVICE

HTC Corporation, Taoyuan...

1. A manufacturing method of a casing of an electronic device, comprising:forming a shell by an injection molding technology, and the shell comprising a button portion; and
electroplating a sensing assembly on an inner surface of the shell, the sensing assembly comprising a first conductive line and two first contacts, wherein the first conductive line forms a strain sensing pattern on the button portion, and the two first contacts connect to two ends of the first conductive line, respectively; and
forming a protective layer on the inner surface of the shell, and the protective layer covers the first conductive line and exposes the two first contacts.

US Pat. No. 10,113,242

SYSTEMS AND METHODS FOR PRODUCING METAL CLUSTERS; FUNCTIONALIZED SURFACES; AND DROPLETS INCLUDING SOLVATED METAL IONS

Purdue Research Foundatio...

1. A method for producing metal cluster ions, the method comprising:applying voltage and heat to a metal salt at atmospheric pressure to thereby ionize the metal salt and produce metal cluster ions; and
directing the metal cluster ions to a target.

US Pat. No. 10,113,238

GOLD PLATE COATED STAINLESS MATERIAL AND METHOD OF PRODUCING GOLD PLATE COATED STAINLESS MATERIAL

TOYO KOHAN CO., LTD., To...

1. A gold plate coated stainless material comprising:a stainless steel sheet coated with a gold plated layer which is deposited directly on a passivation film present on a surface of the stainless steel sheet, wherein
the passivation film has a surface composition having a Cr/O value comprised within a range from 0.05 to 0.2 and a Cr/Fe value comprised within a range from 0.5 to 0.8, the Cr/O value and the Cr/Fe value obtained by Auger electron spectroscopy analysis.

US Pat. No. 10,113,235

SOURCE GAS SUPPLY UNIT, FILM FORMING APPARATUS AND SOURCE GAS SUPPLY METHOD

Tokyo Electron Limited, ...

1. A source gas supply method to a film forming unit for forming a film on a substrate, comprising:generating a source gas containing vaporized raw material by supplying a carrier gas to a raw material tank accommodating a solid or liquid raw material at a plurality of carrier gas flow rate set values using a first flow path;
switching a destination of the source gas to the first flow path so that the source gas bypasses the film forming unit to discharge the source gas;
measuring flow rates of the source gas at the carrier gas flow rate set values, respectively while the source gas bypasses the film forming unit using the first flow path;
storing in a storage unit a vaporization flow rate table maintaining correspondence between the carrier gas flow rate set values and vaporization flow rates which are flow rates of the vaporized raw material contained in the source gas and obtained from the difference between the measured flow rates of the source gas and the carrier gas flow rate set values;
calculating a corresponding carrier gas flow rate set value corresponding to a specified vaporization flow rate set value required by a user for forming the film on the substrate by using the vaporization flow rate table; and
generating a corresponding source gas by supplying a corresponding carrier gas to the raw material tank at the calculated corresponding carrier gas flow rate set value while supplying the generated corresponding source gas to the film forming unit using a second flow path, wherein the first flow path and the second flow path are different, and wherein the corresponding source gas flows to the film forming unit using the second flow path when forming the film on the substrate.

US Pat. No. 10,113,233

MULTI-ZONE TEMPERATURE CONTROL FOR SEMICONDUCTOR WAFER

Taiwan Semiconductor Manu...

1. An apparatus, comprising: a controller programmed to receive a plurality of measurements of a critical dimension (CD) at respective locations in a circuit pattern etched from a film comprising a film material on a first semiconductor substrate; and a single wafer chamber for forming a second film of the film material on a second semiconductor substrate, wherein a first film material is deposited on the first semiconductor substrate by the single wafer chamber, the single wafer chamber being responsive to a control signal from the controller to adjust a thickness of the second film at one or more of the respective locations based on the plurality of measurements of the CD, wherein the single wafer chamber has a platen that supports the second semiconductor substrate, and wherein the single wafer chamber includes a plurality of heating elements, wherein each of the plurality of heating elements is moveable with respect to the platen; and a plurality of driver units, wherein a single driver unit is coupled to one respective heating element to independently actuate said one respective heating element in a plane parallel to a wafer-engaging surface of the platen, wherein each single driver unit is configured to move one respective heating element in two orthogonal directions in the plane parallel to the wafer-engaging surface of the platen, and wherein each single driver unit is configured to provide independent adjustments to positions of one respective heating element.

US Pat. No. 10,113,232

AZIMUTHAL MIXER

Lam Research Corporation,...

1. An apparatus for supplying process gases to a semiconductor processing gas distribution system, the apparatus comprising:a main passage;
a first plenum that substantially encircles the main passage;
a first inlet, the first inlet fluidically connected to the first plenum;
a manifold block including a first block and a second block; and
a plurality of first radial passages, each first radial passage spanning between, and fluidically connecting, the main passage with the first plenum, wherein:
the first block and the second block are adjacent to one another,
the first radial passages are defined by opposing surfaces of the first block and the second block,
the first plenum is defined by opposing surfaces of the first block and the second block, and
a first feed-through fluidically connects the first inlet with the first plenum.

US Pat. No. 10,113,231

PROCESS KIT INCLUDING FLOW ISOLATOR RING

APPLIED MATERIALS, INC., ...

1. A process chamber comprising:a sidewall;
a substrate support having an outer ledge;
a gas inlet beneath the substrate support;
a first liner having an annular inner surface separated from the outer ledge of the substrate support by a first gap, the first liner further having an outer angled surface; and
a flow isolator ring having an inner bottom surface configured to be disposed on the outer ledge of the substrate support when the substrate support is in a raised position and an outer bottom surface extending outwardly relative to the inner bottom surface, the outer bottom surface overlying the first gap, wherein the flow isolator ring further comprises:
a top surface located inwardly relative to an outer edge of the outer bottom surface; and
an outer angled surface between the top surface and the outer bottom surface, the outer angled surface oriented inwardly towards the top surface, wherein
the outer bottom surface of the flow isolator ring is configured to be disposed on the first liner when the substrate support is in a lowered position, and
the outer angled surface of the flow isolator ring and the outer angled surface of the first liner are configured to be collinear when the substrate support is in the lowered position.

US Pat. No. 10,113,229

TECHNIQUES FOR CONTROLLING ION/NEUTRAL RATIO OF A PLASMA SOURCE

Varian Semiconductor Equi...

20. A method for increasing a ratio of reactive ions to a neutral species, the method comprising:providing a processing apparatus comprising:
a plasma source chamber including a first gas inlet delivering a first gas; and
a deposition chamber coupled to the plasma source chamber, the deposition chamber including a second gas inlet and a third gas inlet delivering a point of use (POU) gas to an area proximate a substrate disposed within the deposition chamber, wherein the POU gas is different than the first gas, wherein the POU gas is delivered from the second gas inlet and from the third inlet on opposite sides of the first gas, and wherein the POU gas is delivered from the second gas inlet and from the third gas inlet in a same direction orthogonal to the substrate;
increasing a pressure within the deposition chamber in an area proximate the substrate to increase an amount of reactive ions present for impacting the substrate when an ion beam is delivered to the substrate, wherein the pressure is increased by optimizing each of the following: a gas flow rate of a first inlet of the plasma source chamber, a gas flow rate of at least one gas inlet of the first and second inlets of the deposition chamber, a distance between the substrate and the plasma source chamber, a pump speed of a deposition chamber pump fluidly connected with the deposition chamber, and a pump speed of a plasma source chamber pump fluidly connected with the plasma source chamber; and
generating the ion beam for delivery to the substrate, wherein the increase in pressure in the area proximate the substrate increases a ratio of reactive ions to neutral species impacting the substrate when the ion beam is delivered to the substrate, and wherein the ion beam is delivered to the substrate at a non-perpendicular angle relative to the substrate.

US Pat. No. 10,113,225

MASKANT FOR USE IN ALUMINIZING A TURBINE COMPONENT

Howmet Corporation, Whit...

1. A mask for preventing aluminizing of a region of a component made of a superalloy, comprising a mixture of chromium-containing powder, nickel-containing powder and refractory powder wherein the chromium-containing powder comprises metallic chromium powder or chromium-containing metal alloy powder, the chromium-containing powder being present in the mixture in an amount greater than about 10 weight % effective (a) to supply chromium to form a chromium-enriched surface on the superalloy component beneath the mask during aluminizing of an unmasked region or (b) to supply chromium to a pre-existing chromium-enriched chromized surface on the superalloy component beneath the mask to retain the chromium-enriched chromized surface during aluminizing of an unmasked region.

US Pat. No. 10,113,224

FRICTION ADJUSTMENT INTERFACE BETWEEN TWO PARTS MADE OF NICKEL OR NICKEL OR COBALT-CHROMIUM ALLOY THAT ARE IN RELATIVE MOTION AGAINST ONE ANOTHER AT HIGH TEMPERATURE

Airbus Operations (S.A.S....

1. An adjustment interface inserted between a first part made of nickel, a nickel alloy or a cobalt-chromium alloy that is in relative motion with a second part made of nickel, a nickel alloy or a cobalt-chromium alloy, wherein the adjustment interface comprises two adjustment layers comprising:a first adjustment layer deposited on the first part of the two parts and having a composition that makes it possible, with the friction with the second part, to create a glaze-type layer;
a second adjustment layer deposited on the second part for cooperation with the first adjustment layer by acting as a catalyst for an oxide formed by friction with the first adjustment layer.

US Pat. No. 10,113,221

BEARING STEEL

AKTIEBOLAGET SKF, Gothen...

1. A method of heat treating a bearing component composed of a steel alloy composition that comprises:0.6 to 0.7 wt. % carbon,
1.3 to 1.7 wt. % silicon,
1.2 to 1.6 wt. % manganese,
0.8 to 1.2 wt. % chromium,
0.15 to 0.4 wt. % molybdenum,
0.05 to 0.25 wt. % nickel,
0.003 to 0.01 wt. % vanadium,
0.005 to 0.05 wt. % aluminium,
0.05 to 0.3 wt. % copper,
0 to 0.5 wt. % cobalt,
0 to 0.1 wt. % niobium,
0 to 0.1 wt. % tantalum,
0 to 150 ppm nitrogen, and
0 to 50 ppm calcium,
the balance being iron and 0.3 wt. % or less of unavoidable impurities,
the method comprising:
(i) heating the steel alloy composition at a temperature of 865-900° C. for 50-100 minutes to at least partially austenitise the composition;
(ii) quenching the steel alloy composition to a temperature of 190-210° C. and holding the steel alloy composition at the temperature of 190-210° C. for 12-36 hours;
(iii) isothermally heating the steel alloy composition at a temperature of 200-280° C. until the steel alloy composition has a microstructure that comprises 5 to 10 vol.% retained austenite and at least 80 vol. % bainitic-ferrite and has a Vickers hardness of at least 650 HV; and
(iv) subjecting the bearing component having 5 to 10 vol.% retained austenite and at least 80 vol. % bainitic-ferrite to a surface finishing technique.

US Pat. No. 10,113,214

ALKALI METAL AND/OR ALKALI EARTH METAL EXTRACTION METHOD

AISIN SEIKI KABUSHIKI KAI...

1. A method for extracting at least one of an alkali metal and an alkali earth metal from a solid containing at least one of the alkali metal and the alkali earth metal, the method comprisingadding the solid to a neutral amino acid-containing aqueous solution so as to elute at least one of the alkali metal and the alkali earth metal in the neutral amino acid-containing aqueous solution,
contacting an acidic gas with the eluted at least one of the alkali metal and the alkali earth metal in the neutral amino acid-containing aqueous solution to precipitate the at least one of the alkali metal and the alkali earth metal as a salt,
recovering the salt,
adding another solid containing at least one of an alkali metal and an alkali earth metal to the neutral amino acid-containing aqueous solution from which the salt was recovered to elute at least one of the alkali metal and the alkali earth metal in the neutral amino acid-containing aqueous solution, and
determining a mixing ratio of water, the neutral amino acid and the solid so that peak values of a rate of elution and an amount of the salt precipitated are matched, the rate of elution being obtained by dividing an amount of the at least one of the alkali metal and the alkali earth metal eluted in the neutral amino acid-containing aqueous solution by an amount of the at least one of the alkali metal and the alkali earth metal contained in the solid, or an integrated value of the rate of elution and the amount of the salt precipitated is maximized,
wherein the neutral amino acid-containing aqueous solution has an isoelectric point within a range of ±1.5 with respect to a first acid dissociation constant of the acidic gas, and the neutral amino acid is DL-alanine and is a chelating agent that reacts with at least one of the alkali metal and the alkali earth metal to form a chelated complex.

US Pat. No. 10,113,212

SENSORS

THE UNIVERSITY OF MANCHES...

1. A system for monitoring a microstructure of a metal target, comprising:a plurality of electromagnetic sensors for outputting a magnetic field, wherein an excitation signal output by each of the electromagnetic sensors is a multi-frequency waveform, detecting a resultant magnetic field and outputting a detection signal in response thereto; and
a control unit arranged to receive the detection signals from the plurality of electromagnetic sensors, to determine a phase change between the output magnetic field and the resultant magnetic field at each of a plurality of frequencies forming the multi-frequency waveform for each of the plurality of electromagnetic sensors, to determine a microstructure development rate of a metal target at the plurality of electromagnetic sensors based on the phase changes, and to determine a deviation of the microstructure development rate from a predetermined microstructure development rate.

US Pat. No. 10,113,197

PURIFIED POLYMERASE / TEMPLATE COMPLEXES

Pacific Biosciences of Ca...

1. A method for isolating active polymerase enzyme nucleic acid complexes comprising:contacting a phi-29 DNA polymerase enzyme or a modified form thereof with a primer-hybridized template nucleic acid to produce a population of polymerase enzyme nucleic acid complexes in solution, at least some of which are active;
exposing the population of polymerase enzyme nucleic acid complexes with a resin having nucleoside polyphosphate moieties attached thereto in the presence of a stabilizing divalent cation under conditions whereby the active polymerase enzyme nucleic acid complexes bind to the nucleoside polyphosphate moieties, wherein the divalent cation is Ca++, Sr++, Ba++, Ti++, or Ni++;
washing the resin to remove components not bound to the resin; and
eluting the active polymerase enzyme nucleic acid complexes bound to the nucleoside polyphosphate moieties attached to the resin by contacting the resin with a chelating agent, thereby isolating the active polymerase enzyme nucleic acid complexes.

US Pat. No. 10,113,194

GAS TESTING UNIT AND METHOD

LANZATECH NEW ZEALAND LIM...

1. A method comprising:(a) evaluating suitability of a test C1-containing substrate obtained from an industrial process for use in a biological conversion process comprising:
(b) providing a gas testing unit, comprising:
(i) a first bioreactor stage for evaluating the performance of a reference C1-containing substrate;
(ii) a second bioreactor stage for evaluating the performance of the test C1-containing substrate;
(iii) an analytical section configured for analysis of both gaseous and liquid products of the first and second bioreactors;
wherein the gas testing unit is capable of being housed within a container having a volume of less than about 6 m3 and transportable to multiple locations;
(c) feeding the reference C1-containing substrate to the first bioreactor of the gas testing unit containing a first culture of a C1-fixing microorganism the first bioreactor operated at a set of target operating conditions;
(d) feeding the test C1-containing substrate obtained from the industrial process to the second bioreactor of the gas testing unit containing a second culture of the C1-fixing microorganism, the second bioreactor operated at the same set of target conditions as the first bioreactor;
(e) analyzing both gaseous and liquid products of the first and second bioreactors employing the analytical section of the gas testing unit to determine the performance of the first and second bioreactors; and
(f) comparing the performance of the first bioreactor, relative to the performance of the second bioreactor to determine the suitability of the test C1-containing substrate obtained from the industrial source for use in a biological conversion process;
the process characterized in that it is carried out at a site of the industrial process.

US Pat. No. 10,113,185

UTILIZATION OF PHOSPHOKETOLASE IN THE PRODUCTION OF MEVALONATE, ISOPRENOID PRECURSORS, AND ISOPRENE

Danisco US Inc., Palo Al...

1. Recombinant microbial cells capable of producing isoprene, wherein the cells comprise (a) one or more heterologous nucleic acids encoding a polypeptide having phosphoketolase activity; (b) attenuated activity of an acetate kinase enzyme by (i) deletion of an endogenous acetate kinase gene; or (ii) replacement of an endogenous promoter of the endogenous acetate kinase gene with a synthetic constitutively low-expressing promoter; (c) one or more nucleic acids encoding one or more polypeptides of the complete MVA pathway; and (d) a heterologous nucleic acid encoding an isoprene synthase polypeptide, wherein culturing of said recombinant cells in a suitable media provides for the production of isoprene, and wherein the production of isoprene is increased relative to cells that do not comprise the one or more heterologous nucleic acids encoding a polypeptide having phosphoketolase activity.

US Pat. No. 10,113,153

P450-BM3 VARIANTS WITH IMPROVED ACTIVITY

Codexis, Inc., Redwood C...

1. A recombinant polynucleotide sequence encoding a recombinant cytochrome P450-BM3 variant, wherein said sequence comprises SEQ ID NO: 3, and further wherein said recombinant cytochromie P450-BM3 variant oxidizes at least three organic substrates.

US Pat. No. 10,113,151

COMPOSITION OF VIRAL VECTORS IN LECITHIN LIPOSOMES, PREPARATION METHOD AND TREATMENT METHODS

The Regents of the Univer...

1. A method of preparing a formulation comprising a viral particle encapsulated in an anionic liposome, wherein the viral particle is a recombinant adenovirus, the method comprising:a) preparing a mixture by dissolving lecithin, cholesterol and PEG in an organic solvent;
b) drying the mixture under vacuum to form a dry lipid film;
c) mixing the dried lipid film with recombinant adenovirus particles and hydrating the dried lipid film by exposing it to a physiological solution, and thereby forming multilamellar vesicles;
d) sonicating said vesicles and thereby forming a formulation with recombinant adenovirus particles encapsulated in the anionic liposomes;
e) binding non-encapsulated recombinant adenovirus particles with an antibody; and
f) separating the encapsulated recombinant adenovirus particles from the non-encapsulated recombinant adenovirus particles bound to the antibody by magnetic immunoprecipitation with magnetic beads linked to protein G; and thereby extracting the non-encapsulated recombinant adenovirus particles from the formulation.

US Pat. No. 10,113,144

METHOD FOR PRODUCING CELL CONCENTRATE, AND CELL SUSPENSION TREATMENT SYSTEM

KANEKA CORPORATION, Osak...

1. A method for producing a cell concentrate using a cell suspension treatment system including:a storage container of a cell suspension, which has a solution inlet port, a circulation outlet port, and a circulation inlet port;
a cell suspension treatment device for concentrating the cell suspension by separating liquid from the cell suspension by filtration, the device including a container having a cell suspension introduction port, a cell suspension lead-out port, and a filtrate outlet, which is filled with a hollow fiber separation membrane,
a circulation circuit for concentrating the cell suspension while circulating the cell suspension between the storage container and the cell suspension treatment device, the circuit being constituted by an introduction communication tube communicating the circulation inlet port of the storage container and the cell suspension introduction port of the cell suspension treatment device and a lead-out communication tube communicating the cell suspension lead-out port of the cell suspension treatment device and the circulation outlet port of the storage container;
a collection container of a cell concentrate obtained by concentration;
a collection path for feeding the cell concentrate in the storage container, the cell suspension treatment device, and the circulation circuit to the collection container;
an injection path for injecting a solution into the solution inlet port of the storage container;
a detecting unit for detecting a volume of the cell concentrate in the storage container or the introduction communication tube of the circulation circuit, and
an air bubble sensor on a path from the storage container to an air filter, wherein the air filter is provided above the storage container so as to make a pressure of an inner portion of the storage container to an atmospheric pressure,
the method comprising:
a) a step of storing the cell suspension in the storage container by supplying the cell suspension to the storage container through the solution inlet port;
b) a step of concentrating the cell suspension by feeding the cell suspension in the storage container to the cell suspension treatment device through the introduction communication tube of the circulation circuit, and then, circulating the cell suspension into the storage container through the lead-out communication tube of the circulation circuit;
c) a step of terminating the step b) by detecting the volume of the cell concentrate in the storage container or the introduction communication tube of the circulation circuit; and
d) a step of feeding and collecting the cell concentrate in the storage container, the cell suspension treatment device, and the circulation circuit to the collection container through the collection path.

US Pat. No. 10,113,125

METHOD AND SYSTEM FOR COGENERATING GAS-STEAM BASED ON GASIFICATION AND METHANATION OF BIOMASS

SUNSHINE KAIDI NEW ENERGY...

1. A system for cogenerating gas-steam based on gasification and methanation of biomass, the system comprising:a gasification unit comprising a gasifier, the gasifier comprising an upper part that is disposed higher with respect to the ground than the remaining parts of the gasifier, a waste heat boiler, an external thermostatic heater, and an outlet segment;
a shift unit;
a purification unit;
a methanation unit; and
a methane concentration unit;wherein:the gasifier is adapted to yield a crude gasified gas;
the waste heat boiler is connected to the upper part;
the waste heat boiler is adapted to recycle waste heat of the crude gasified gas to yield a first intermediate pressure superheated steam;
the external thermostatic heater is disposed at the outlet segment to keep a gasification temperature within the gasifier at 1,500-1,800° C.; and
the purification unit is adapted to purify the crude gasified gas to yield a purified syngas.

US Pat. No. 10,113,120

PROCESSING FLUID FROM A WELL

STATOIL PETROLEUM AS, St...

1. Apparatus for processing fluid from a well, the apparatus comprising:a first wall portion adjacent a first region;
a second wall portion adjacent a second region;
said first and second regions arranged to let fluid pass therethrough;
the apparatus further comprising:
a first heat exchanger which includes said first wall portion, said first heat exchanger being arranged to heat said first wall portion to release wax from said first wall portion into said fluid at said first region; and
a second heat exchanger which includes said second wall portion, said second heat exchanger being arranged in a first configuration to cool said fluid at said second region during said heating of the first wall portion to cause wax from said fluid to deposit on said second wall portion, wherein said second heat exchanger is operable in said first configuration to cool said fluid at said second region, and in a second configuration, different from said first configuration, to heat said second wall portion to release wax from the second wall portion into said fluid; and
an outlet arranged to receive therein said fluid from said first and second regions,
wherein the first heat exchanger and the second heat exchanger are disposed in a parallel configuration.

US Pat. No. 10,113,116

LIQUID CRYSTAL COMPOUND AND LIQUID CRYSTAL COMPOSITION EMPLOYING THE SAME

DAXIN MATERIALS CORPORATI...

1. A liquid crystal composition, comprising: a first component and a third component; whereinthe first component comprises at least two liquid crystal compounds represented by Formula (I)

wherein
R1 represents hydrogen, a C1-C10 alkyl group, or a C2-C10 alkenyl group, where the C1-C10 alkyl group or the C2-C10 alkenyl group is unsubstituted or at least one —CH2— of the C1-C10 alkyl group or the C2-C10 alkenyl group is replaced by —O—, —S—, —O—CO—, —OC—O—, or —O—CO—O—, provided that the —O—, —S—, —O—CO—, —OC—O—, and —O—CO—O— do not directly bond to one another, and/or at least one hydrogen of the C1-C10 alkyl group or the C2-C10 alkenyl group is substituted by halogen, CN, or CF3;
each of A1, A2, A3, and A4 independently represents a 1,4-phenylene group, a 1,4-cyclohexylene group, a divalent dioxabicyclo[2.2.2]octylene group, a divalent trioxabicyclo[2.2.2]octylene group, or a divalent 2,5-indanylene group, where the 1,4-phenylene group, the 1,4-cyclohexylene group, or the divalent 2,5-indanylene group is unsubstituted or at least one hydrogen of the 1,4-phenylene group, the 1,4-cyclohexylene group, or the divalent 2,5-indanylene group is substituted by halogen, CN, or CF3, and/or at least one —CH2— of the 1,4-cyclohexylene group is replaced by —O—, —S—, —O—CO—, —OC—O—, or —O—CO—O—, provided that the —O—, —S—, —O—CO—, —OC—O—, and —O—CO—O— do not directly bond to one another, and/or at least one —CH2— of the divalent 2,5-indanylene group is replaced by —O— or —S—, provided that the —O— and —S— do not directly bond to one another;
each of Z1, Z2, Z3 and Z4 independently represents a single bond, a C1-C4 alkylene group, a C2-C4 alkenylene group, a C2-C4 alkynylene group, —O—CO—, or —CO—O—, where the C1-C4 alkylene group, the C2-C4 alkenylene group, or the C2-C4 alkynylene group is unsubstituted or at least one hydrogen of the C1-C4 alkylene group, the C2-C4 alkenylene group, or the C2-C4 alkynylene group is substituted by halogen, and/or at least one —CH2— of the C1-C4 alkylene group, the C2-C4 alkenylene group, or the C2-C4 alkynylene group is replaced by —O— or —S—, provided that the —O— and —S— do not directly bond to each other, wherein at least one of Z1, Z2, Z3, and Z4 of one of the at least two liquid crystal compounds does not represent —OCF2— or —CF2O—;
X represents hydrogen, halogen, CN, CF3, or CCl3; and
each of m, n, o, and p independently represents 0 or 1, and m+n+o+p>0;
the third component comprises at least one liquid crystal compound represented by Formula (III)

wherein
R6 represents halogen, —CF3, —OCH?CF2, or —OCF3;
R5 represents hydrogen, a C1-C10 alkyl group, or a C2-C10 alkenyl group, where the C1-C10 alkyl group or the C2-C10 alkenyl group is unsubstituted or at least one —CH2— of the C1-C10 alkyl group or the C2-C10 alkenyl group is replaced by —O—, —S—, —CO—, —O—CO—, —CO—O—, or —O—CO—O—, and wherein the —O—, —S—, —CO—, —O—CO—, —CO—O—, and —O—CO—O— do not directly bond to one another, and/or at least one hydrogen of the C1-C10 alkyl group or the C2-C10 alkenyl group is substituted by halogen, CN, or CF3;
each of A7, A8, A9, and A10 independently represents a 1,4-phenylene group, a 1,4-cyclohexylene group, a divalent dioxabicyclo[2.2.2]octylene group, a divalent trioxabicyclo[2.2.2]octylene group, or a divalent 2,5-indanylene group, where the 1,4-phenylene group, the 1,4-cyclohexylene group, or the divalent 2,5-indanylene group is unsubstituted or at least one hydrogen of the 1,4-phenylene group, the 1,4-cyclohexylene group, or the divalent 2,5-indanylene group is substituted by halogen or CN, and/or at least one —CH2— of the 1,4-cyclohexylene group is replaced by —O—, —NH—, or —S—, provided that the —O—, —NH—, and —S— do not directly bond to one another, or at least one —CH2— of the divalent 2,5-indanylene group is replaced by —O—, —NH—, or —S—, provided that the —O—, —NH—, and —S— do not directly bond to one another;
each of Z7, Z8 and Z9 independently represents a single bond, a C1-C4 alkylene group, a C2-C4 alkenylene group, a C2-C4 alkynylene group, —CO—O—, or —O—CO—, where the C1-C4 alkylene group, the C2-C4 alkenylene group, or the C2-C4 alkynylene group is unsubstituted or at least one hydrogen of the C1-C4 alkylene group, the C2-C4 alkenylene group, or the C2-C4 alkynylene group is substituted by halogen, and/or at least one —CH2— of the C1-C4 alkylene group, the C2-C4 alkenylene group, or the C2-C4 alkynylene group is replaced by —O— or —S—, and —O— does not directly bond to —O— or —S—, and —S— does not directly bond to —S—, and wherein at least one of Z7, Z8 and Z9 represents —OCF2— or —CF2O—; and
each of s, t, u, and v independently represents 0, 1, 2, or 3, and s+t+u+v?3.

US Pat. No. 10,113,114

APPARATUS AND METHOD FOR COATING PARTICULATE MATERIAL

BASF Corporation, Florha...

1. A method of applying a functional additive to a particulate landscaping material, the method comprising:feeding a particulate landscaping material into a mixing chamber from a hopper, the hopper comprising two opposing sides, a baffle, a conveyor, and a sensor, the two opposing sides, the baffle, and the conveyor defining a gate;
delivering a flow of additive mixture to a plurality of spray nozzles within the mixing chamber, the additive mixture comprising a functional additive and a carrier;
operating at least one of the plurality of spray nozzles to direct an atomized spray of additive mixture into the mixing chamber for contact with particulate landscaping material in the mixing chamber;
agitating the particulate landscaping material within the mixing chamber at least one of during and after directing the atomized spray of additive mixture into the mixing chamber;
conveying the particulate landscaping material with the additive mixture applied thereto to a mixing chamber outlet;
during the feeding, delivering, operating, agitating and conveying steps, intermittently determining a volumetric flow rate of the particulate landscape material through the mixing chamber by measuring the volumetric flow rate of the particulate landscape material through the gate with the sensor;
intermittently comparing the determined volumetric flow rate of the particulate landscape material to a predetermined target flow rate of the particulate landscape material;
adjusting, based on said comparing, the volumetric flow rate of the particulate landscape material through the mixing chamber by adjusting the volumetric flow rate of the particulate landscape material through the gate.

US Pat. No. 10,113,112

PREPARATION OF NANORODS

Massachusetts Institute o...

1. A method of preparing a core-shell nanorod comprising growing a shell of a core-shell nanorod (M1X1)M2X2 in a solution through a slow-injection of M2 precursor solution and X2 precursor solution to a suspension of M1X1 nanocrystals to form the shell in a first shell growth step, and, after stopping the first shell growth step, further growing the shell of the core-shell nanorod (M1X1)M2X2 in the solution through a slow-injection of M2 precursor solution and X2 precursor solution to a suspension of M1X1 nanocrystals to form a thicker shell in a second shell growth step and, wherein the core-shell nanorod includes a M1X1 core.

US Pat. No. 10,113,109

OXO- AND HYDROXO-BASED COMPOSITE INORGANIC LIGANDS FOR QUANTUM DOTS

Lumileds LLC, San Jose, ...

1. A particulate luminescent material comprising quantum dots with a capping agent coordinating to the quantum dots, wherein the capping agent comprises a zincate ion (Zn(OH)42?), and the particulate luminescent material comprises particles having an inorganic matrix hosting the quantum dots with inorganic capping agents.

US Pat. No. 10,113,105

HYDROPHOBIZING AGENTS COMPRISING AN OLIGOMERIC POLYAMINE AND METHODS FOR COATING PARTICULATES THEREWITH

Halliburton Energy Servic...

1. A method comprising:providing a composition comprising:
a hydrophobizing agent comprising an oligomeric polyamine having a carbon atom:nitrogen atom ratio of about 4:1 or more, and a plurality of hydrophobic groups bonded to at least a portion of the nitrogen atoms in the oligomeric polyamine; and
forming coated particulates comprising a coating of the hydrophobizing agent on one or more particulates,
wherein the hydrophobizing agent is cationic and comprises at least one of: one quaternized nitrogen atom, or one protonated nitrogen atom.

US Pat. No. 10,113,097

PROCESS FOR THE PRODUCTION OF A THERMALLY CONDUCTIVE ARTICLE

1. A process for the production of a thermally conductive article, said process comprising:pleating at least one thermally anisotropic sheet having a first thermal conductivity in a first plane which is higher than a second thermal conductivity in a second plane that is perpendicular to the first plane to form a pleated structure, said pleated structure comprises a plurality of pleats, each said pleat having a first surface and a second surface; and
compacting the pleated structure so that said first and second surfaces which face each other due to the formation of said pleats are at least partially brought into direct contact with each other, said pleated structure having an upper surface and a lower surface,
wherein the thermally anisotropic sheet includes at least one thermally anisotropic polymer layer.

US Pat. No. 10,113,095

REINFORCED GRAPHITIC MATERIAL

MICROSOFT TECHNOLOGY LICE...

1. A method for making a reinforced graphitic material, the method comprising:sorbing a solution of an organic compound into void space between graphitic platelets of a graphitic host material;
mechanically pressing the graphitic host material while heating the graphitic host material to evaporate a solvent of the solution and deposit sorbed organic compound into the void space;
heating the graphitic host material with the sorbed organic compound to pyrolyze the sorbed organic compound and thereby deposit elemental carbon in the void space, the elemental carbon crosslinking the graphitic platelets of the graphitic host material; and
after heating the graphitic host material with the sorbed organic compound to pyrolyze the sorbed organic compound, mechanically re-pressing while heating the graphitic host material.

US Pat. No. 10,113,089

ARTICLES AND METHODS COMPRISING POLYACRYLATE PRIMER WITH NITROGEN-CONTAINING POLYMER

3M Innovative Properties ...

1. An optical film stack comprising:a first optical film bonded to a microstructured surface layer comprising microstructured prisms, of a second optical film with a cured adhesive layer comprising an interpenetrating network of the reaction product of a polyacrylate and polymerizable monomer; wherein the second optical film further comprises a primer layer disposed between the cured adhesive layer and the microstructured surface layer of the second optical film and the primer layer consists essentially of a polyacrylate and a nitrogen-containing polymer, and wherein at least a portion of the prisms comprise a post extending from an apex of the prisms that functions as a optically non-active bonding portion.

US Pat. No. 10,113,088

LABEL MANUFACTURING METHOD AND LABEL

SATO HOLDINGS KABUSHIKI K...

1. A label manufacturing method comprising:applying a first adhesive to a base sheet to form an adhesive layer;
partially applying a second adhesive which is an acrylate-based bonding adhesive to the applied first adhesive layer, on the same side of the base sheet as the first adhesive layer;
irradiating the first adhesive and the partially applied acrylate-based bonding adhesive applied to the first adhesive layer with an ultraviolet ray such that only the acrylate-based bonding adhesive is cured; and
cutting the base sheet where the acrylate-based bonding adhesive has been applied to define a separated label.

US Pat. No. 10,113,075

POLYCYCLIC PHOTOINITIATORS

IGM Malta Limited, (MT)

1. A photopolymerizable composition comprising:(A) at least one ethylenically unsaturated photopolymerizable compound and
(B) at least one photoinitiator compound of formula (I):

wherein
X is O, S, a direct bond or CR16R17;
Y is O or S;
R1, R2, R3, R4, R5, R6, R7 and R8 independently of each other are hydrogen, halogen, C1-C4alkyl, C5-C7cycloalkyl, phenyl, C1-C4alkoxy, C5-C7cycloalkoxy, phenoxy, C1-C4alkylthio, C5-C7cycloalkylthio, phenylthio, di(C1-C4alkyl)amino, di(C5-C7cycloalkyl)amino, N-morpholinyl, N-piperidinyl or a group of formula (II) or (III):

provided that
one of R1, R2, R3 or R4 is a group of formula (II) or (III) and one of R5, R6, R7 or R8 is a group of formula (II) or (III);
R9 and R10 independently of each other are C1-C4alkyl or together with the C atom to which they are attached form a 5-membered, 6-membered or 7-membered carbocyclic ring;
R11 is hydrogen, C1-C4alkyl, C5-C7cycloalkyl, 2-tetrahydropyranyl or Si(C1-C4alkyl)3;
R12 and R13 independently of each other are C1-C4alkyl, C2-C12alkenyl, phenyl-C1-C4alkyl, phenyl-C1-C4alkyl which is substituted by C1-C4alkyl, or R12 and R13 together with the C atom to which they are attached form a 5-membered, 6-membered or 7-membered carbocyclic ring;
R14 and R15 independently of each other are C1-C4alkyl, C5-C7cycloalkyl, or together with the N atom to which they are attached form a 5-membered, 6-membered or 7-membered ring, which may contain additional heteroatoms O, S or N;
R16 and R17 independently of each other are hydrogen, C1-C8alkyl, C5-C7cycloalkyl, phenyl-C1-C4alkyl, phenyl or together with the C atom to which they are attached form a 5-membered, 6-membered or 7-membered ring;
provided that;
(1) compounds wherein R2 is a group of formula (III) and R14 and R15 together with the N atom to which they are attached form a 6-membered ring, which contains an additional heteroatom O, X is a direct bond and Y is O; and
(2) compounds wherein R2 is a group of formula (III) and R14 and R15 together with the N atom to which they are attached form a 6-membered ring, which contains an additional heteroatom O and X and Y are S; and
(3) compounds wherein R7 is a group of formula (III) and R14 and R15 together with the N atom to which they are attached form a 6-membered ring, which contains an additional heteroatom O and X and Y are S; are excluded.

US Pat. No. 10,113,070

PRETREATMENT COMPOSITIONS AND METHODS OF TREATING A SUBSTRATE

PPG industries Ohio, Inc....

1. A pretreatment composition for treating a metal substrate, comprising:(a) a Group IIIB metal and/or a Group IVB metal present in a total amount of 20 ppm to 1000 ppm (calculated as elemental metal) based on the total weight of the pretreatment composition;
(b) a compound containing at least six phosphorus-containing acid groups or salts thereof present in an amount of 1.82×10?4 moles per liter to 2.73×10?2 moles per liter of pretreatment composition; and
(c) an electropositive metal;
wherein the molar ratio of (a) to (b) is at least 3:1;
wherein the pretreatment composition is capable of reacting with and chemically altering the substrate surface and binding to it to form a film that affords corrosion protection.

US Pat. No. 10,113,040

POLYMER FILM, POLARIZING PLATE AND LIQUID CRYSTAL DISPLAY DEVICE

FUJIFILM CORPORATION, To...

1. A polymer film, which comprises:a carbonyl bond-containing polymer; and
a compound having ?h of equal to or higher than 11.0 and ?? of equal to or lower than 1.50, wherein the ?h is a value of hydrogen-bonding capacity calculated by Hoy method and the ?? is a value calculated by equation 1:
??=|x?13.3|   Equation 1
wherein, in equation 1, ? represents an interatomic distance in the polymer film between atoms most distant from each other among molecules in the compound, excluding a hydrogen atom, calculated by molecular dynamics calculation,
wherein said compound is represented by a compound selected from the group:
i) formula (I-1):
(Q3-(L32-L31)n3-A-(L41-L42)n4)m-Z1
wherein each of L31 and L41 independently represents an alkylene group, and the alkylene group may be substituented, each of L32 and L42 independently represents a single bond, or any one of or any combination of —O—, —NR1—, —S— and —C(?O)—, R1 represents a hydrogen atom or a substituent, each of n3 and n4 independently represents an integer of 0 to 20, either n3 or n4 is an integer equal to or higher than 1, and when L31, L32, L41 and L42 exist in plural number, they may be the same as or different from each other, Q3 represents a substituent, Z1 represents an m-valent linking group, and A represents *—O—C(?O)—NH— or *—NH—C(?O)—O—, where * represents a bonding position with L41, m represents an integer of 2 to 6, and Q3 and A existing in plural number may be the same as or different from each other, respectively, and at least one of Q3 and Z1 contains a ring structure,
wherein Z1 is

*—CH2-CH(-*)—CH2-* is formula

*—CH2-C(CH3)(CH2-*)—CH2-* is formula
or*—CH2-CH(C2H5)(CH2-*)—CH2-* is formula

ii) formula (I-3):

wherein each of L71 and L81 independently represents an alkylene group, and the alkylene group may be substituented, each of L72 and L82 independently represents a single bond or any one of or any combination of —O—, —NR1—, —S— and —C(?O), R1 represents a hydrogen atom or a substituent, each of n7 and n8 independently represents an integer of 0 to 12, either n7 or n8 is an integer equal to or higher than 1, and when L71, L72, L81 and L82 exist in plural number, they may be the same as or different from each other, Q5 represent a substituted or an unsubstituted phenyl group, a substituted or unsubstituted cyclohexyl group, a methyl group, an ethyl group, a propyl group, an isopropyl group or a t-butyl group, A represents *—O—C(?O)—NH— or *—NH—C(?O)—O—, where * represents a bonding position with L81, and R2a represents an alkyl group having 1 to 3 carbon atoms, m2 represents an integer of 2 or 3, and Q5 and A existing in plural number may be the same as or different from each other, respectively, a represents an integer of 0 to 10, and, when a is an integer equal to or higher than 1, R2a existing in plural number may be the same as or different from each other;
iii) formula (I-5):

wherein each of L71 and L81 independently represents an alkylene group, and the alkylene group may be substituented, each of L72 and L82 independently represents a single bond or any one of or any combination of —O—, —NR1—, —S— and —C(?O), each of n7 and n8 independently represents an integer of 0 to 12, either n7 or n8 is an integer equal to or higher than 1, and when L71, L72, L81 and L82 exist in plural number, they may be the same as or different from each other, Q5 represent a substituted or an unsubstituted phenyl group, a substituted or unsubstituted cyclohexyl group, a methyl group, an ethyl group, a propyl group, an isopropyl group or a t-butyl group, A represents *—O—C(?O)—NH— or *—NH—C(?O)—O—, where * represents a bonding position with L81, Q5 and A existing in plural number may be the same as or different from each other, respectively, m3 represents 1 or 2, and each of R3 and R4 independently represents a hydrogen atom or a methyl group;
iv) formula (II):

wherein in formula (II) each of L1a and L1b independently represents a single bond, an alkylene group, or a group represented by any of the above-described formulas (2A) to (2E), or a group consisting of a combination of a group represented by any of formulas (2A) to (2E) and two or three alkylene groups, and each of Q1a and Q1b independently represents a substituent, at least one of Q1a and Q1b represents a phenyl group which may have been substituted by an alkyl group having 1 to 3 carbon atoms or an alkoxy group having 1 to 3 carbon atoms;
v) formula (III):

wherein in formula (III) each of L1a and L1b independently represents a single bond, an alkylene group, or a group represented by any of the above-described formulas (2A) to (2E), or a group consisting of a combination of a group represented by any of formulas (2A) to (2E) and two or three alkylene groups, and each of Q1a and Q1b independently represents a substituent, at least one of Q1a and Q1b represents a phenyl group which may have been substituted by an alkyl group having 1 to 3 carbon atoms or an alkoxy group having 1 to 3 carbon atoms;
vi) formula (A):
QA-La1-X—C(?O)—NH-La2-QB
wherein X represents —NR—, and R represents a hydrogen atom or a substituent, each of La1 and La2 independently represents a single bond, or any one of or any combination of an alkylene group, an arylene group, —O—, —NR1—, —S— and —C(?O)—, R1 represents a hydrogen atom or a substituent, each of QA and QB independently represents a substituent, and at least one of QA and QB represents a polar group being a residue of a compound having a C log P value equal to or lower than 0.85, or a terminal group contained in the substituent.

US Pat. No. 10,113,034

POLYMERS FROM STABILIZED IMINES

International Business Ma...

1. A method for producing a polymer, comprising:forming a reaction mixture comprising a non-polar solvent and an imine compound comprising electron withdrawing or accepting groups;
adding a multifunctional nucleophile to the mixture; and
heating the mixture at a temperature from about 50° C. to about 150° C. to produce a polymer.

US Pat. No. 10,113,033

POLYMER CONJUGATE FOR DELIVERY OF A BIOACTIVE AGENT

POLYACTIVA PTY LTD, Melb...

1. A polymer-bioactive agent conjugate comprising:a polymer backbone comprising a plurality of triazole moieties; and
a plurality of releasable prostaglandin analogues covalently bonded to and pendant from the polymer backbone from the 1-position of the prostaglandin analogue via an ester linking group.

US Pat. No. 10,113,020

INJECTION STRETCH BLOW MOLDED ARTICLES AND RANDOM COPOLYMERS FOR USE THEREIN

FINA TECHNOLOGY, INC., H...

1. A method of forming an injection stretch blow molded (ISBM) article comprising:providing a metallocene random propylene-based copolymer, wherein the metallocene random propylene-based copolymer has a melting point of from about 115° C. to about 175° C., a microtacticity of from about 89% to 99%, a molecular weight (Mw) of 170,000 to 210,000, and a recrystallization temperature of from 85° C. to 100° C., as measured by DSC;
injection molding the metallocene random propylene-based copolymer in the absence of a clarifier into a preform; and
stretch-blowing the preform into an article.

US Pat. No. 10,113,019

METHODS OF CHANGING POLYOLEFIN PRODUCTION CONDITIONS TO MITIGATE SMALL GELS IN A POLYOLEFIN ARTICLE

Univation Technologies, L...

1. A method comprising:contacting in a fluidized bed gas phase reactor an olefin monomer with a catalyst system in the presence of an induced condensing agent (ICA) and optionally hydrogen to produce a first polyolefin having a first melt index;
increasing by 10% or less (1) a concentration of the ICA in the reactor, (2) a residence time of the first polyolefin in the reactor, or (3) both to produce a second polyolefin having a second melt index, wherein the second melt index is within 10% of the first melt index; and
wherein a first thin film formed of the first polyolefin has a larger count of a small gel than a second thin film formed of the second polyolefin, wherein the first and second thin film are produced by a same procedure, and wherein the small gel is a gel particle having a diameter of 201 microns to 600 microns and counting the small gel is determined by surface inspection of a 50 micron ±5 micron thin film using optoelectronic analysis.

US Pat. No. 10,113,018

SHAPE CONTROLLED PRO-CATALYST AND A PROCESS FOR PREPARING THE SAME

Reliance Industries Limit...

1. A single-pot process for the preparation of a shape controlled pro-catalyst; said process comprising the following steps:a. reacting at least one alkanol with magnesium metal using at least one modifier and at least one solvent resulting in evolution of hydrogen gas; increasing the evolution of hydrogen gas in a controlled manner by increasing the temperature in a graded manner to 100° C. to obtain a mass, and
b. subjecting the mass to drying to obtain a free flowing pro-catalyst.

US Pat. No. 10,113,017

POLYETHYLENE COMPOSITION HAVING HIGH STRESS CRACKING RESISTANCE

Basell Polyolefine GmbH, ...

1. A polyethylene composition comprising:A) a polyethylene having the properties of
1) density from about 0.930 to about 0.945 g/cm3 determined according to ISO 1183 at 23° C.;
2) a ratio of MIF/MIP from about 10 to less than about 30, where MIF is the melt flow index at 190° C. with a load of 21.60 kg, and MIP is the melt flow index at 190° C. with a load of 5 kg, both determined according to ISO 1133;
3) a MIF from about 3 to about 25 g/10 min;
4) a Mz equal to or greater than 1,500,000 g/mol, measured by GPC-MALLS (Gel Permeation Chromatography coupled with Multi-angle laser-light scattering); and
5) a long-chain branching index, LCBI, equal to or lower than about 0.55 at a molecular weight of 1,000,000 g/mol,
wherein LCBI is the ratio of the measured mean-square radius of gyration Rg, measured by GPC-MALLS, to the mean-square radius of gyration for a linear PE having the same molecular weight.

US Pat. No. 10,113,013

CATALYST COMPONENTS FOR THE POLYMERIZATION OF OLEFINS

Basell Poliolefine Italia...

1. A solid catalyst component for the polymerization of olefins comprising Mg, Ti and an electron donor of the formula (I):
where each Q is a group —COOR1 in which R1 is selected from C1-C15 hydrocarbon groups, optionally containing a heteroatom selected from the group consisting of a halogen, P, S, N, and O; or a group —CON(R2)2 in which R2 groups, equal to or different from each other, are selected from hydrogen or R1 groups which are optionally fused together to form one or more cycles; and A is a bivalent bridging group with the proviso that the Q groups cannot be simultaneously a group —COOR1 or —CON(R2)2.

US Pat. No. 10,112,999

ANTI-PRLR ANTIBODY-DRUG CONJUGATES (ADC) AND USES THEREOF

AbbVie Inc., North Chica...

1. An antibody-drug conjugate (ADC) comprising the structure of Formula (X), or a salt thereof,
wherein Formula (X) comprises a monoclonal anti-PRLR antibody (Ab) conjugated to “n” cytotoxic warheads,
wherein said monoclonal anti-PRLR antibody comprises:
i. a heavy chain variable region comprising a CDRH1 sequence comprising SEQ ID NO: 3, a CDRH2 sequence comprising SEQ ID NO: 4, and a CDRH3 sequence comprising SEQ ID NO: 5;
ii. a light chain variable region comprising a CDRL1 sequence comprising SEQ ID NO: 8, a CDRL2 sequence comprising SEQ ID NO: 9, and a CDRL3 sequence comprising SEQ ID NO: 10; and
iii. a mutation comprising S239C in a heavy chain constant region, wherein the numbering is in accordance with Kabat,
wherein said monoclonal anti-PRLR antibody is conjugated to said cytotoxic warheads through said S239C mutation in said heavy chain constant region, and
wherein “n” is 2.

US Pat. No. 10,112,975

BENZODIAZEPINE DIMERS, CONJUGATES THEREOF, AND METHODS OF MAKING AND USING

Briston-Myers Squibb Comp...

1. A compound having a structure represented by formula (IIb-03):

US Pat. No. 10,112,973

PROCESS FOR THE PREPARATION OF RAMIPRIL

SANOFI-AVENTIS DEUTSCHLAN...

1. A process for preparing a compound of formula (VI)
wherein:
R1 is CO2R4 or CN;
R2 is (C1-C4)alkyl;
R3 is
(C1-C4)alkyl, wherein one, two or three hydrogen atoms are optionally replaced by fluorine, (C1-C4)alkoxy, or
phenyl;
R4 is (C1-C4)alkyl; and
Ar is
phenyl, optionally substituted with one, two or three substituents independently selected from the group consisting of halogen, (C1-C4)alkoxy and (C1-C4)alkyl, or
1-naphthyl;
comprising
reacting a chiral amine of formula (IV)

wherein:
R1 is CO2R4 or CN;
R4 is (C1-C4)alkyl; and
Ar is
phenyl, optionally substituted with one, two or three substituents independently selected from the group consisting of halogen, (C1-C4)alkoxy and (C1-C4)alkyl, or
1-naphthyl;
with a 2-acylamino-acrylic acid ester of formula (V)

wherein:
R2 is (C1-C4)alkyl; and
R3 is
(C1-C4)alkyl, wherein one, two or three hydrogen atoms are optionally replaced by fluorine, (C1-C4)alkoxy, or
phenyl,
to produce the compound of formula (VI).

US Pat. No. 10,112,970

PROCESS FOR THE PREPARATION OF 17-DESOXY-CORTICOSTEROIDS

Taro Pharmaceutical Indus...

1. A process for preparing a compound of Formula I
in which R1 is OH and R2 is H, or R1 and R2 form together a double bond with O, R3 is H and R4 is CH3, or R3 is CH3 and R4 is H, and wherein at least one of X1-5 is independently Cl, Br or F, and all other of X1-5 are H, comprising the steps of:
(a) reacting a compound of formula II

in which R1-R4 and X1-5 are as defined in Formula I with Trimethylsilyl Iodide in a solution of an aprotic solvent, wherein the molar ratio between Trimethylsilyl Iodide and the compound of Formula II is about 2:1 to about 10:1;
(b) quenching the reaction of step (a);
(c) extracting the compound of Formula I from the solution of step (b) using an organic solvent to yield an organic layer comprising the compound of Formula I; and
(d) isolating the compound of Formula I from the organic layer of step (c).

US Pat. No. 10,112,968

INHIBITORS OF PROTEIN METHYLTRANSFERASE DOT1L AND METHODS OF USE THEREOF

Epizyme, Inc., Cambridge...

1. A compound of Formula (IIa) or a pharmaceutically acceptable salt or ester thereof:wherein,A is O or CH2;
each of G and J, independently, is H, halo, C(O)OH, C(O)O—C1-C6 alkyl or ORa, Ra being H, C1-C6 alkyl, C(O)—C1-C6 alkyl, or silyl, wherein C(O)O—C2-C6 alkyl, C1-C6 alkyl or C(O)—C1-C6 alkyl is optionally substituted with one or more substituents selected from the group consisting of halo, cyano hydroxyl, carboxyl, C1-C6 alkoxyl, amino, mono-C1-C6 alkylamino, di-C1-C6 alkylamino, and C3-C8 cycloalkyl;
each X independently is N or CRx, in which Rx is H, halo, hydroxyl, carboxyl, cyano, or RS1, RS1 being amino, C1-C6 alkoxyl, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C8 cycloalkyl, C6-C10 aryl, 4 to 6-membered heterocycloalkyl, or 5 to 6-membered heteroaryl, and RS1 being optionally substituted with one or more substituents selected from the group consisting of halo, hydroxyl, carboxyl, cyano, C1-C6 alkoxyl, amino, mono-C1-C6 alkylamino, di-C1-C6 alkylamino, C3-C8 cycloalkyl, C6-C10 aryl, 4 to 6-membered heterocycloalkyl, and 5 to 6-membered heteroaryl;
L1 is N(Y), S, SO, or SO2;
L2 is CO or absent when L1 is N(Y) or L2 is absent when L1 is S, SO, or SO2, in which Y is H, Rd, SO2Rd, or CORd when L2 is absent, or Y is H or Rd when L2 is CO, Rd being C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C8 cycloalkyl, C6-C10 aryl, 4 to 6-membered heterocycloalkyl, or 5 to 6-membered heteroaryl, and Rd being optionally substituted with one or more substituents selected from the group consisting of C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, halo, hydroxyl, carboxyl, cyano, C1-C6 alkoxyl, C1-C6 alkylsulfonyl, amino, mono-C1-C6 alkylamino, di-C1-C6 alkylamino, C3-C8 cycloalkyl, C6-C10 aryl, 4 to 6-membered heterocycloalkyl, and 5 to 6-membered heteroaryl and with C3-C8 cycloalkyl, C6-C10 aryl, 4 to 6-membered heterocycloalkyl, or 5 to 6-membered heteroaryl further optionally substituted with C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, halo, hydroxyl, carboxyl, C(O)OH, C(O)O—C1-C6 alkyl, OC(O)—C1-C6 alkyl, cyano, C1-C6 alkoxyl, amino, mono-C1-C6 alkylamino, di-C1-C6 alkylamino, C3-C8 cycloalkyl, C6-C10 aryl, 4 to 6-membered heterocycloalkyl, or 5 to 6-membered heteroaryl;
each of R1, R2, R3, R4, R5, R6, and R7, independently, is H, halo, hydroxyl, carboxyl, cyano, RS2, RS2 being amino, C1-C6 alkoxyl, C1-C6 alkyl, C2-C6 alkenyl, or C2-C6 alkynyl, and each RS2 being optionally substituted with one or more substituents selected from the group consisting of halo, hydroxyl, carboxyl, cyano, C1-C6 alkoxyl, amino, mono-C1-C6 alkylamino, di-C1-C6 alkylamino, C3-C8 cycloalkyl, C6-C10 aryl, 4 to 6-membered heterocycloalkyl, and 5 to 6-membered heteroaryl;
R8 is H, halo or RS3, RS3 being C1-C6 alkyl, C2-C6 alkenyl, or C2-C6 alkynyl, and RS3 being optionally substituted with one or more substituents selected from the group consisting of halo, hydroxyl, carboxyl, cyano amino, C1-C6 alkoxyl, mono-C1-C6 alkylamino, di-C1-C6 alkylamino, and C3-C8 cycloalkyl; and
Q is H, NH2, NHRb, NRbRc, Rb, ?O, OH, or ORb, in which each of Rb and Rc independently is C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C8 cycloalkyl, C6-C10 aryl, 4 to 7-membered heterocycloalkyl, 5 to 10-membered heteroaryl, or -M1-T1 in which M1 is a bond or C1-C6 alkyl linker optionally substituted with halo, cyano, hydroxyl or C1-C6 alkoxyl and T1 is C3-C8 cycloalkyl, C6-C10 aryl, 4 to 6-membered heterocycloalkyl, or 5 to 10-membered heteroaryl, or Rb and Rc, together with the N atom to which they attach, form 4 to 7-membered heterocycloalkyl having 0 or 1 additional heteroatoms to the N atom optionally substituted with C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, halo, hydroxyl, carboxyl, C(O)OH, C(O)O—C1-C6 alkyl, OC(O)—C1-C6 alkyl, cyano, C1-C6 alkoxyl, amino, mono-C1-C6 alkylamino, di-C1-C6 alkylamino, C3-C8 cycloalkyl, C6-C10 aryl, 4 to 6-membered heterocycloalkyl, or 5 to 6-membered heteroaryl, and each of Rb, Rc, and T1 is optionally substituted with one or more substituents selected from the group consisting of C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, halo, hydroxyl, carboxyl, cyano, C1-C6 alkoxyl, amino, mono-C1-C6 alkylamino, di-C1-C6 alkylamino, C3-C8 cycloalkyl, C6-C10 aryl, 4 to 6-membered heterocycloalkyl, and 5 to 6-membered heteroaryl;
R9 is
in which:each of Re, Rf, Rg, and Rh, independently is -M2-T2, in which M2 is a bond, SO2, SO, S, CO, CO2, O, O—C1-C4 alkyl linker, C1-C4 alkyl linker, NH, or N(Rt), Rt being C1-C6 alkyl, and T2 is H, halo, or RS4, RS4 being C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C8 cycloalkyl, C6-C10 aryl, 4 to 8-membered heterocycloalkyl, or 5 to 10-membered heteroaryl, and each of O—C1-C4 alkyl linker, C1-C4 alkyl linker, Rt, and RS4 being optionally substituted with one or more substituents selected from the group consisting of halo, hydroxyl, carboxyl, cyano, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 alkoxyl, amino, mono-C1-C6 alkylamino, di-C1-C6 alkylamino, C3-C8 cycloalkyl, C6-C10 aryl, 4 to 6-membered heterocycloalkyl, and 5 to 6-membered heteroaryl, Ri is H or C1-C6 alkyl optionally substituted with one or more substituents selected from the group consisting of halo, hydroxyl, carboxyl, cyano, C1-C6 alkoxyl, amino, mono-C1-C6 alkylamino, di-C1-C6 alkylamino, C3-C8 cycloalkyl, C6-C10 aryl, 4 to 6-membered heterocycloalkyl, and 5 to 6-membered heteroaryl;
q is 0, 1, 2, 3, or 4;
m is 0, 1, or 2; and
n is 0, 1, or 2.

US Pat. No. 10,112,964

DITHIOLENE METAL COMPLEX COLORLESS IR ABSORBERS

BASF SE, Ludwigshafen (D...

1. A method of using colorless IR absorbers comprisinga) treating a material with a compound from the group consisting of

wherein the material is a security print, an invisible and IR readable bar code,
a laser-welded plastic, a dried print, a fixed toner on paper, a laser marked plastic, or a heated preform,
optionally a further IR absorber; and
b) using the treated material of a) for security printing, invisible and IR readable bar codes, laser-welding of plastics, drying of print, fixing of toners on paper, laser marking, and heating of plastics preforms.

US Pat. No. 10,112,959

METAL COMPLEX AND COLOR CONVERSION FILM COMPRISING SAME

LG CHEM, LTD., Seoul (KR...

1. A compound of the following Chemical Formula 1:
wherein, in Chemical Formula 1,
at least one of R1 to R5 is selected from among the following structural formulae;

R6 is hydrogen; a nitrile group; a substituted or unsubstituted alkyl group; a substituted or unsubstituted cycloalkyl group; a substituted or unsubstituted alkoxy group; a substituted or unsubstituted aryl group; a substituted or unsubstituted alkylaryl group; or a substituted or unsubstituted aromatic or aliphatic heterocyclic group;
X1 and X2 are the same as or different from each other, and each independently F; a nitrile group; a substituted or unsubstituted alkynyl group; a substituted or unsubstituted alkyl group; a substituted or unsubstituted alkoxy group; a substituted or unsubstituted aryloxy group; a substituted or unsubstituted arylalkoxy group; a substituted or unsubstituted aryl group; or a substituted or unsubstituted aromatic or aliphatic heterocyclic group, or bond to each other to form an aromatic or aliphatic ring;
X3 is a halogen group; a nitrile group; a carbonyl group; an ester group; an amide group; a sulfonate group; a substituted or unsubstituted alkyl group; a fluoroalkyl group; a substituted or unsubstituted cycloalkyl group; a substituted or unsubstituted alkoxy group; a substituted or unsubstituted alkylsulfoxy group; a substituted or unsubstituted silyl group; a substituted or unsubstituted phosphine oxide group; or a substituted or unsubstituted alkylaryl group;
Y1 is CR101 or N, Y2 is CR102 or N, Y3 is CR103 or N and Y4 is CR104 or N; and
groups of R1 to R5 that are not the above-mentioned structural formulae, R8 to R13 and R101 to R104 are the same as or different from each other, and each independently hydrogen; deuterium; a halogen group; a nitrile group; a nitro group; a carbonyl group; an ester group; an imide group; an amide group; a sulfonate group; a substituted or unsubstituted alkyl group; a substituted or unsubstituted cycloalkyl group; a substituted or unsubstituted alkoxy group; a substituted or unsubstituted aryloxy group; a substituted or unsubstituted alkylthioxy group; a substituted or unsubstituted arylthioxy group; a substituted or unsubstituted alkylsulfoxy group; a substituted or unsubstituted arylsulfoxy group; a substituted or unsubstituted alkenyl group; a substituted or unsubstituted silyl group; a substituted or unsubstituted boron group; a substituted or unsubstituted arylphosphine group; a substituted or unsubstituted phosphine oxide group; a substituted or unsubstituted arylalkyl group; a substituted or unsubstituted alkylaryl group; a substituted or unsubstituted aryl group; or a substituted or unsubstituted aromatic or aliphatic heterocyclic group, and R9 and R10 bond to each other to form an aliphatic or aromatic ring, and R12 and R13 bond to each other to form an aliphatic or aromatic ring.

US Pat. No. 10,112,958

N-[2-(2-AMINO-6,6-DISUBSTITUTED-4,4A,5,6-TETRAHYDROPYRANO[3,4-D][1,3]THIAZIN-8A(8H)-YL)-1,3-THIAZOL-4-YL] AMIDES

Pfizer Inc., New York, N...

1. A compound of Formula IwhereinR1 is selected from the group consisting of:
C1-6alkyl optionally substituted with one to three fluoro or C1-3alkoxy;
C5-9bicycloalkyl optionally substituted with one to three R4; and
a 5- to 6-membered heteroaryl, having one to four heteroatoms independently selected from N, O or S, wherein at least one of the heteroatoms is N and wherein said N is optionally substituted with R5; and wherein said 5- to 6-membered heteroaryl is optionally substituted on carbon with one to three R4;
R2 and R3 are each independently selected from C1-6alkyl or C3-7cycloalkyl; wherein the C1-6alkyl is optionally substituted with one to three fluoro or C1-3alkoxy; or R2 and R3 taken together with the carbon to which they are attached form a C3-6cycloalkyl ring or a 4- to 6-membered heterocycloalkyl ring, each of which is optionally and independently substituted with one to three fluoro, C1-3alkyl or C1-3alkoxy;
R4 at each occurrence is independently selected from the group consisting of halogen, hydroxy, cyano, C1-6alkyl, C1-6alkoxy, C3-6alkenyl, C3-6alkenyloxy, C3-6alkynyl, C3-6alkynyloxy, C1-6alkoxy-C1-6alkyl, C3-6cycloalkoxy, C3-6cycloalkyl, C3-6cycloalkyl-C1-6alkyl, C3-6cycloalkyl-C1-6alkoxy, 4- to 6-membered heterocycloalkyl and 4- to 6-membered heterocycloalkyl-C1-6alkyl; wherein said C1-6alkyl, C1-6alkoxy, C3-6alkenyl, C3-6alkenyloxy, C3-6alkynyl, C3-6alkynyloxy, C1-6alkoxy-C1-6alkyl, C3-6 cycloalkoxy, C3-6cycloalkyl, C3-6cycloalkyl-C1-6alkyl, C3-6cycloalkyl-C1-6alkoxy, 4- to 6-membered heterocycloalkyl and 4- to 6-membered heterocycloalkyl-C1-6alkyl are each optionally substituted with one to three substituents independently selected from fluoro, chloro, hydroxy, cyano, methyl, fluoromethyl, difluoromethyl, trifluoromethyl, methoxy, fluoromethoxy, difluoromethoxy and trifluoromethoxy; and
R5 is hydrogen, C1-6alkyl, C3-6alkenyl, C3-6alkynyl, C1-6alkoxy-C1-6alkyl, C3-6cycloalkyl, C3-6cycloalkyl-C1-6alkyl, 4- to 6-membered heterocycloalkyl and 4- to 6 membered heterocycloalkyl-C1-6alkyl; wherein said C1-6alkyl, C3-6alkenyl, C3-6alkynyl, C1-6alkoxy-C1-6alkyl, C3-6cycloalkyl, C3-6cycloalkyl-C1-6alkyl, 4- to 6-membered heterocycloalkyl and 4-to 6-membered heterocycloalkyl-C1-6alkyl are each optionally substituted with one to three substituents independently selected from fluoro, chloro, hydroxy, cyano, methyl, fluoromethyl, difluoromethyl, trifluoromethyl, methoxy, fluoromethoxy, difluoromethoxy and trifluoromethoxy; or R4 and R5 taken together can be a C3-5alkylene;
or a tautomer thereof or a pharmaceutically acceptable salt of said compound or tautomer.

US Pat. No. 10,112,954

BICYCLIC HETEROARYL DERIVATIVES HAVING INHIBITORY ACTIVITY FOR PROTEIN KINASE

HANMI PHARM. CO., LTD., ...

7. A pharmaceutical composition comprising the compound of claim 1 as an active ingredient and a pharmaceutically acceptable carrier.

US Pat. No. 10,112,953

11,13-MODIFIED SAXITOXINS FOR THE TREATMENT OF PAIN

SITEONE THERAPEUTICS, INC...

1. A Compound of Formula (I):
where
R1 is H, OH, —OS(O)3?, —OS(O)2R5, —OC(O)R6, —NR7C(O)R7a, —OC(O)NR10R10a, —NR11R11a, —NH3+, —NR13S(O)2R13a, or —NR14C(O)NR14aR14b;
X1 is R3 and X2 is R9; or
X1 and X2 together with the —NC(O)— to which they are attached form a 5 or 6-membered ring where X1, X2, and the one or two additional ring atoms are independently selected from —C(O)—, —O—, —S—, —NR8—, and —C(R4)(R4a)— provided that only one is selected from —O—, —S—, and —NR8—; and where the 5 or 6-membered ring is optionally fused at two adjacent carbon atoms, or is optionally fused at one carbon atom and one nitrogen atom which are adjacent to each other, to a form a saturated or unsaturated 6-12 membered bicyclic ring; where the 1, 2, 3, 4, 5, or 6 additional bicyclic ring atoms are independently —CR12? or —C(R12)2—; or
X1 and X2 together with the —NC(O)— to which they are attached form 1,3-dioxo-hexahydro-1H-4,7-methanoisoindolyl;
each R4 and R4a is independently H; C1-6alkyl; or when the 6-12 membered ring is fused at a —C(R4)(R4a—, one or both of the R4 and R4a on the —C(R4)(R4a)— form a single or double bond with an adjacent ring atom;
R8 is hydrogen; C1-6alkyl; phenyl optionally substituted with 1, 2, or 3 groups independently selected from halo, C1-6alkyl, halo-C1-6alkyl, hydroxy, C1-6alkoxy, halo-C1-6alkoxy, nitro, and cyano; or when the 6-12 membered ring is fused at an —NR8—, the R8 forms a single bond with an adjacent ring atom;
each R12 is independently hydrogen, halo, C1-6alkyl, halo-C1-6alkyl, or aryl;
R3 is —C(O)C1-6alkyl, —C(O)OC1-6alkyl, or —C(O)phenyl where the phenyl is optionally substituted with one or two groups independently selected from halo, C1-6alkyl, halo-C1-6alkyl, C1-6alkoxy, and aryl;
R5 is H, C1-6alkyl, or aryl optionally substituted with 1, 2, 3, or 4 R5a;
each R5a, when present, is independently halo, C1-6alkyl, halo-C1-6alkyl, hydroxy, C1-6alkoxy, halo-C1-6alkoxy, C1-6alkylthio, halo-C1-6alkylthio, C1-6alkylsulfinyl, halo-C1-6alkylsulfinyl, C1-6alkylsulfonyl, halo-C1-6alkylsulfonyl, nitro, amino, C1-6alkylamino, di- C1-6alkylamino, phenyl, or cyano;
R9 is C1-6alkyl, C1-6alkoxy, or phenyl where the phenyl is optionally substituted with one or two groups independently selected from halo, C1-6alkyl, halo-C1-6alkyl, C1-6alkoxy, and aryl;
R6 is C1-6alkyl; aryl optionally substituted with 1, 2, 3, or 4 R6a; aralkyl where the aryl is optionally substituted with 1, 2, 3, or 4 R6a; heteroaryl optionally substituted with 1, 2, 3, or 4 R6a; heterocyclic optionally substituted with 1, 2, 3, or 4 R6a; biphenyl optionally substituted on either ring with 1, 2, or 3 R6a; or cycloalkyl optionally substituted with 1, 2, 3, or 4 groups independently selected from C1-6alkyl and halo-C1-6alkyl;
each R6a, when present, is independently halo, C1-6alkyl, halo-C1-6alkyl, hydroxy, C1-6alkoxy, halo-C1-6alkoxy, nitro, C1-6alkylthio, halo-C1-6alkylthio, C1-6alkylsulfinyl, halo-C1-6alkylsulfinyl, C1-6alkylsulfonyl, halo-C1-6alkylsulfonyl, amino, C1-6alkylamino, di-C1-6alkylamino, phenyl, or cyano;
R7 is hydrogen or C1-6alkyl;
R7a is C1-6alkyl; aryl optionally substituted with 1, 2, 3, or 4 R7b; aralkyl where the aryl is optionally substituted with 1, 2, 3, or 4 R7b; heteroaryl optionally substituted with 1, 2, 3, or 4 R7b; heterocyclic optionally substituted with 1, 2, 3, or 4 R7b; biphenyl optionally substituted on either ring with 1, 2, or 3 R7b; or cycloalkyl optionally substituted with 1, 2, 3, or 4 groups independently selected from C1-6alkyl and halo-C1-6alkyl;
each R7b, when present, is independently halo, C1-6alkyl, halo-C1-6alkyl, hydroxy, C1-6alkoxy, halo-C1-6alkoxy, nitro, C1-6alkylthio, halo-C1-6alkylthio, C1-6alkylsulfinyl, halo-C1-6alkylsulfinyl, C1-6alkylsulfonyl, halo-C1-6alkylsulfonyl, amino, C1-6alkylamino, di-C1-6alkylamino, phenyl, or cyano;
R10 is hydrogen or C1-6alkyl;
R10a is C1-6alkyl; aryl optionally substituted with 1, 2, 3, or 4 R10b; aralkyl where the aryl is optionally substituted with 1, 2, 3, or 4 R10b; phenylcarbonyl where the phenyl is optionally substituted with 1, 2, or 3 R10b; heteroaryl optionally substituted with 1, 2, 3, or 4 R10b; heterocyclic optionally substituted with 1, 2, 3, or 4 R10b; biphenyl optionally substituted on either ring with 1, 2, 3, or 4 R10b, or cycloalkyl optionally substituted with 1, 2, 3, or 4 groups independently selected from C1-6alkyl and halo-C1-6alkyl;
each R10b, when present, is independently halo, C1-6alkyl, halo-C1-6alkyl, hydroxy, C1-6alkoxy, halo-C1-6alkoxy, nitro, C1-6alkylthio, halo-C1-6alkylthio, C1-6alkylsulfinyl, halo-C1-6alkylsulfinyl, C1-6alkylsulfonyl, halo-C1-6alkylsulfonyl, amino, C1-6alkylamino, di-C1-6alkylamino, phenyl, or cyano;
R11 is hydrogen or C1-6alkyl;
R11a is C1-6alkyl; aryl optionally substituted with 1, 2, 3, or 4 R11b; aralkyl where the aryl is optionally substituted with 1, 2, 3, or 4 R11b; heteroaryl optionally substituted with 1, 2, 3, or 4 R11b; heterocyclic optionally substituted with 1, 2, 3, or 4 R11b; biphenyl optionally substituted on either ring with 1, 2, 3, or 4 R11b; or cycloalkyl optionally substituted with 1, 2, or 3 groups independently selected from C1-6alkyl and halo-C1-6alkyl; and
each R11b, when present, is independently halo, C1-6alkyl, halo-C1-6alkyl, hydroxy, C1-6alkoxy, halo-C1-6alkoxy, nitro, C1-6alkylthio, halo-C1-6alkylthio, C1-6alkylsulfinyl, halo-C1-6alkylsulfinyl, C1-6alkylsulfonyl, halo-C1-6alkylsulfonyl, amino, C1-6alkylamino, di-C1-6alkylamino, phenyl, or cyano;
R13 is hydrogen or C1-6alkyl;
R13a is C1-6alkyl; aryl optionally substituted with 1, 2, 3, or 4 R13b; aralkyl where the aryl is optionally substituted with 1, 2, 3, or 4 R13b, heteroaryl optionally substituted with 1, 2, 3, or 4 R13b; heterocyclic optionally substituted with 1, 2, 3, or 4 R13b, biphenyl optionally substituted on either ring with 1, 2, 3, or 4 R13b; or cycloalkyl optionally substituted with 1, 2, 3, or 4 groups independently selected from C1-6alkyl and halo-C1-6alkyl;
each R13b, when present, is independently halo, C1-6alkyl, halo-C1-6alkyl, hydroxy, C1-6alkoxy, halo-C1-6alkoxy, C1-6alkylthio, halo-C1-6alkylthio, C1-6alkylsulfinyl, halo-C1-6alkylsulfinyl, C1-6alkylsulfonyl, halo-C1-6alkylsulfonyl, nitro, amino, C1-6alkylamino, di-C1-6alkylamino, phenyl, or cyano;
R14 is hydrogen or C1-6alkyl;
R14a is hydrogen or C1-6alkyl;
R14b) is C1-6alkyl; aryl optionally substituted with 1, 2, 3, or 4 R14c; aralkyl where the aryl is optionally substituted with 1, 2, 3, or 4 R14c; heteroaryl optionally substituted with 1, 2, 3, or 4 R14c; heterocyclic optionally substituted with 1, 2, 3, or 4 R14c; biphenyl optionally substituted on either ring with 1, 2, 3, or 4 R14c; or cycloalkyl optionally substituted with 1, 2, 3, or 4 groups independently selected from C1-6alkyl and halo-C1-6alkyl; and
each R14c, when present, is independently halo, C1-6alkyl, halo-C1-6alkyl, hydroxy, C1-6alkoxy, halo-C1-6alkoxy, C1-6alkylthio, halo-C1-6alkylthio, C1-6alkylsulfinyl, halo-C1-6alkylsulfinyl, C1-6alkylsulfonyl, halo-C1-6alkylsulfonyl, nitro, amino, C1-6alkylamino, di-C1-6alkylamino, phenyl, or cyano; or
a pharmaceutically acceptable salt, stereoisomer, tautomer, or mixture thereof.

US Pat. No. 10,112,950

SUBSTITUTED IMIDAZO[1,2-A]PYRAZINES AS LSD1 INHIBITORS

Incyte Corporation, Wilm...

1. A method for inhibiting lysine specific demethylase-1 activity in a patient, comprising administering to the patient a therapeutically effective amount of a compound of Formula I:or a pharmaceutically acceptable salt thereof, wherein:Ring A is C6-10 aryl or 5-10 membered heteroaryl comprising carbon and 1, 2, 3, or 4 heteroatoms selected from N, O, and S, wherein said C6-10 aryl and 5-10 membered heteroaryl are each optionally substituted by 1, 2, 3, or 4 substituents independently selected from RA;
Ring B is C6-10 aryl; 5-10 membered heteroaryl comprising carbon and 1, 2, 3 or 4 heteroatoms selected from N, O, and S; C3-10 cycloalkyl; or 4-10 membered heterocycloalkyl comprising carbon and 1, 2, 3 or 4 heteroatoms selected from N, O, and S; wherein said C6-10 aryl, 5-10 membered heteroaryl, C3-10 cycloalkyl, and 4-10 membered heterocycloalkyl are each optionally substituted by 1, 2, 3, or 4 substituents independently selected from RB;
R1 is halo, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, Cy1, CN, ORa1, SRa1, C(O)Rb1, C(O)NRc1Rd1, C(O)ORa1, OC(O)Rb1, OC(O)NRc1Rd1, NRc1Rd1, NRc1C(O)Rb1, NRc1C(O)ORa1, NRc1C(O)NRc1Rd1, C(?NRe1)Rb1, C(?NRe1)NRc1Rd1, NRc1C(?NRe1)NRc1Rd1, NRc1S(O)Rb1, NRc1S(O)2Rb1, NRc1S(O)2NRc1Rd1, S(O)Rb1, S(O)NRc1Rd1, S(O)2Rb1, or S(O)2NRc1Rd1; wherein said C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with 1, 2, or 3 substituents independently selected from Cy1, halo, CN, OH, ORa1, SRa1, C(O)Rb1, C(O)NRc1Rd1, C(O)ORa1, OC(O)Rb1, OC(O)NRc1Rd1, NRc1Rd1, NRc1C(O)Rb1, NRc1C(O)ORa1, NRc1C(O)NRc1Rd1, C(?NRe1)Rb1, C(?NRe1)NRc1Rd1, NRc1C(?NRe1)NRc1Rd1, NRc1S(O)Rb1, NRc1S(O)2Rb1, NRc1S(O)2NRc1Rd1, S(O)Rb1, S(O)NRc1Rd1, S(O)2Rb1, and S(O)2NRc1Rd1;
R2 and R3 are each independently selected from H, halo, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, Cy2, CN, ORa2, SRa2, C(O)Rb2, C(O)NRc2Rd2, C(O)ORa2, OC(O)Rb2, OC(O)NRc2Rd2, NRc2Rd2, NRc2C(O)Rb2, NRc2C(O)ORa2, NRc2C(O)NRc2Rd2, C(?NRe2)Rb2, C(?NRe2)NRc2Rd2, NRc2C(?NRe2)NRc2Rd2, NRc2S(O)Rb2, NRc2S(O)2Rb2, NRc2S(O)2NRc2Rd2, S(O)Rb2, S(O)NRc2Rd2, S(O)2Rb2, and S(O)2NRc2Rd2; wherein said C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with 1, 2, or 3 substituents independently selected from Cy2, halo, CN, ORa2, SRa2, C(O)Rb2, C(O)NRc2Rd2, C(O)ORa2, OC(O)Rb2, OC(O)NRc2Rd2, NRc2Rd2, NRc2C(O)Rb2, NRc2C(O)ORa2, NRc2C(O)NRc2Rd2, C(?NRe2)Rb2, C(?NRe2)NRc2Rd2, NRc2C(?NRe2)NRc2Rd2, NRc2S(O)Rb2, NRc2S(O)2Rb2, NRc2S(O)2NRc2Rd2, S(O)Rb2, S(O)NRc2Rd2, S(O)2Rb2, and S(O)2NRc2Rd2;
each RA is independently selected from halo, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, CN, NO2, ORa4, SRa4, C(O)Rb4, C(O)NRc4Rd4, C(O)ORa4, OC(O)Rb4, OC(O)NRc4Rd4, NRc4Rd4, NRc4C(O)Rb4, NRc4C(O)ORa4, NRc4C(O)NRc4Rd4, C(?NRe4)Rb4, C(?NRe4)NRc4Rd4, NRc4C(?NRe4)NRc4Rd4, NRc4S(O)Rb4, NRc4S(O)2Rb4, NRc4S(O)2NRc4Rd4, S(O)Rb4, S(O)NRc4Rd4, S(O)2Rb4, and S(O)2NRc4Rd4, wherein said C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted by 1, 2, or 3, substituents independently selected from halo, C1-6 haloalkyl, CN, NO2, ORa4, SRa4, C(O)Rb4, C(O)NRc4Rd4, C(O)ORa4, OC(O)Rb4, OC(O)NRc4Rd4, NRc4Rd4, NRc4C(O)Rb4, NRc4C(O)ORa4, NRc4C(O)NRc4Rd4, C(?NRe4)Rb4, C(?NRe4)NRc4Rd4, NRc4C(?NRe4)NRc4Rd4, NRc4S(O)Rb4, NRc4S(O)2Rb4, NRc4S(O)2NRc4Rd4, S(O)Rb4, S(O)NRc4Rd4, S(O)2Rb4, and S(O)2NRc4Rd4;
each RB is independently selected from Cy3, halo, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, CN, NO2, ORa5, SRa5, C(O)Rb5, C(O)NRc5Rd5, C(O)ORa5, OC(O)Rb5, OC(O)NRc5Rd5, NRc5Rd5, NRc5C(O)Rb5, NRc5C(O)ORa5, NRc5C(O)NRc5Rd5, C(?NRe5)Rb5, C(?NRe5)NRc5Rd5, NRc5C(?NRe5)NRc5Rd5, NRc5S(O)Rb5, NRc5S(O)2Rb5, NRc5S(O)2NRc5Rd5, S(O)Rb5, S(O)NRc5Rd5, S(O)2Rb5, and S(O)2NRc5Rd5, wherein said C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted by 1, 2, or 3 substituents independently selected from Cy3, halo, C1-6 haloalkyl, CN, NO2, ORa5, SRa5, C(O)Rb5, C(O)NRc5Rd5, C(O)ORa5, OC(O)Rb5, OC(O)NRc5Rd5, NRc5Rd5, NRc5C(O)Rb5, NRc5C(O)ORa5, NRc5C(O)NRc5Rd5, C(?NRe5)Rb5, C(?NRe5)NRc5Rd5, NRc5C(?NRe5)NRc5Rd5, NRc5S(O)Rb5, NRc5S(O)2Rb5, NRc5S(O)2NRc5Rd5, S(O)Rb5, S(O)NRc5Rd5, S(O)2Rb5, and S(O)2NRc5Rd5;
each Cy1, Cy2, Cy3, and Cy4 is independently selected from C6-10 aryl, C3-10 cycloalkyl, 5-10 membered heteroaryl, and 4-10 membered heterocycloalkyl, each of which is optionally substituted with 1, 2, 3, or 4 substituents independently selected from RCy;
each RCy is independently selected from halo, C1-4 alkyl, C1-4 haloalkyl, C1-4 cyanoalkyl, C2-6 alkenyl, C2-6 alkynyl, phenyl, C3-7 cycloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, phenyl-C1-4 alkyl-, C3-7 cycloalkyl-C1-4 alkyl-, (5-6 membered heteroaryl)-C1-4 alkyl-, and (4-7 membered heterocycloalkyl)-C1-4 alkyl-, CN, NO2, ORa6, SRa6, C(O)Rb6, C(O)NRc6Rd6, C(O)ORa6, OC(O)Rb6, OC(O)NRc6Rd6, C(?NRe6)NRc6Rd6, NRc6C(?NRe6)NRc6Rd6, NRc6Rd6, NRc6C(O)Rb6, NRc6C(O)ORa6, NRc6C(O)NRc6Rd6, NRc6S(O)Rb6, NRc6S(O)2Rb6, NRc6S(O)2NRc6Rd6, S(O)Rb6, S(O)NRc6Rd6, S(O)2Rb6, and S(O)2NRc6Rd6, wherein said C1-4 alkyl, C2-6 alkenyl, C2-6 alkynyl, phenyl, C3-7 cycloalkyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, phenyl-C1-4 alkyl-, C3-7 cycloalkyl-C1-4 alkyl-, (5-6 membered heteroaryl)-C1-4 alkyl-, and (4-7 membered heterocycloalkyl)-C1-4 alkyl- are each optionally substituted by 1, 2, or 3 substituents independently selected from C1-6 alkyl, C1-4 haloalkyl, C1-6 cyanoalkyl, halo, CN, NO2, ORa6, SRa6, C(O)Rb6, C(O)NRc6Rd6, C(O)ORa6, OC(O)Rb6, OC(O)NRc6Rd6, C(?NRe6)NRc6Rd6, NRc6C(?NRe6)NRc6Rd6, NRc6Rd6, NRc6C(O)Rb6, NRc6C(O)ORa6, NRc6C(O)NRc6Rd6, NRc6S(O)Rb6, NRc6S(O)2Rb6, NRc6S(O)2NRc6Rd6, S(O)Rb6, S(O)NRc6Rd6, S(O)2Rb6, and S(O)2NRc6Rd6;
each Ra1 is independently selected from C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, and Cy4; wherein said C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with 1, 2, or 3 substituents independently selected from Cy4, halo, CN, ORa3, SRa3, C(O)Rb3, C(O)NRc3Rd3, C(O)ORa3, OC(O)Rb3, OC(O)NRc3Rd3, NRc3Rd3, NRc3C(O)Rb3, NRc3C(O)ORa3, NRc3C(O)NRc3Rd3, C(?NRe3)Rb3, C(?NRe3)NRc3Rd3, NRc3C(?NRe3)NRc3Rd3, NRc3S(O)Rb3, NRc3S(O)2Rb3, NRc3S(O)2NRc3Rd3, S(O)Rb3, S(O)NRc3Rd3, S(O)2Rb3, and S(O)2NRc3Rd3;
each Rb1, Rc1, and Rd1 is independently selected from H, C1-6 alkyl, C1-4 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C6-10 aryl, C3-10 cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C6-10 aryl-C1-4 alkyl-, C3-10 cycloalkyl-C1-4 alkyl-, (5-10 membered heteroaryl)-C1-4 alkyl-, and (4-10 membered heterocycloalkyl)-C1-4 alkyl-, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C6-10 aryl, C3-10 cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C6-10 aryl-C1-4 alkyl-, C3-10 cycloalkyl-C1-4 alkyl-, (5-10 membered heteroaryl)-C1-4 alkyl-, and (4-10 membered heterocycloalkyl)-C1-4 alkyl- are each optionally substituted with 1, 2, 3, 4, or 5 substituents independently selected from C1-4 alkyl, C1-4 haloalkyl, C1-4 cyanoalkyl, halo, CN, ORa7, SRa7, C(O)Rb7, C(O)NRc7Rd7, C(O)ORa7, OC(O)Rb7, OC(O)NRc7Rd7, NRc7Rd7, NRc7C(O)Rb7, NRc7C(O)NRc7Rd7, NRc7C(O)ORa7, C(?NRe7)NRc7Rd7, NRc7C(?NRe7)NRc7Rd7, S(O)Rb7, S(O)NRc7Rd7, S(O)2Rb7, NRc7S(O)2Rb7, NRc7S(O)2NRc7Rd7, and S(O)2NRc7Rd7;
or any Rc1 and Rd1 together with the N atom to which they are attached form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, or 3 substituents independently selected from C1-6 alkyl, C3-7 cycloalkyl, 4-7 membered heterocycloalkyl, C6-10 aryl, 5-6 membered heteroaryl, C1-6 haloalkyl, halo, CN, ORa7, SRa7, C(O)Rb7, C(O)NRc7Rd7, C(O)ORa7, OC(O)Rb7, OC(O)NRc7Rd7, NRc7Rd7, NRc7C(O)Rb7, NRc7C(O)NRc7Rd7, NRc7C(O)ORa7, C(?NRe7)NRc7Rd7, NRc7C(?NRe7)NRc7Rd7, S(O)Rb7, S(O)NRc7Rd7, S(O)2Rb7, NRc7S(O)2Rb7, NRc7S(O)2NRc7Rd7, and S(O)2NRc7Rd7, wherein said C1-6 alkyl, C3-7 cycloalkyl, 4-7 membered heterocycloalkyl, C6-10 aryl, and 5-6 membered heteroaryl are each optionally substituted by 1, 2, or 3 substituents independently selected from halo, C1-4 alkyl, C1-4 haloalkyl, C1-4 cyanoalkyl, CN, ORa7, SRa7, C(O)Rb7, C(O)NRc7Rd7, C(O)ORa7, OC(O)Rb7, OC(O)NRc7Rd7, NRc7Rd7, NRc7C(O)Rb7, NRc7C(O)NRc7Rd7, NRc7C(O)ORa7, C(?NRe7)NRc7Rd7, NRc7C(?NRe7)NRc7Rd7, S(O)Rb7, S(O)NRc7Rd7, S(O)2Rb7, NRc7S(O)2Rb7, NRc7S(O)2NRc7Rd7, and S(O)2NRc7Rd7;
each Ra2, Rb2, Rc2, and Rd2 is independently selected from H, C1-6 alkyl, C1-4 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C6-10 aryl, C3-10 cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C6-10 aryl-C1-4 alkyl-, C3-10 cycloalkyl-C1-4 alkyl-, (5-10 membered heteroaryl)-C1-4 alkyl-, and (4-10 membered heterocycloalkyl)-C1-4 alkyl-, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C6-10 aryl, C3-10 cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C6-10 aryl-C1-4 alkyl-, C3-10 cycloalkyl-C1-4 alkyl-, (5-10 membered heteroaryl)-C1-4 alkyl-, and (4-10 membered heterocycloalkyl)-C1-4 alkyl- are each optionally substituted with 1, 2, 3, 4, or 5 substituents independently selected from C1-4 alkyl, C1-4 haloalkyl, C1-4 cyanoalkyl, halo, CN, ORa7, SRa7, C(O)Rb7, C(O)NRc7Rd7, C(O)ORa7, OC(O)Rb7, OC(O)NRc7Rd7, NRc7Rd7, NRc7C(O)Rb7, NRc7C(O)NRc7Rd7, NRc7C(O)ORa7, C(?NRe7)NRc7Rd7, NRc7C(?NRe7)NRc7Rd7, S(O)Rb7, S(O)NRc7Rd7, S(O)2Rb7, NRc7S(O)2Rb7, NRc7S(O)2NRc7Rd7, and S(O)2NRc7Rd7;
or any Rc2 and Rd2 together with the N atom to which they are attached form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, or 3 substituents independently selected from C1-6 alkyl, C3-7 cycloalkyl, 4-7 membered heterocycloalkyl, phenyl, 5-6 membered heteroaryl, C1-6 haloalkyl, halo, CN, ORa7, SRa7, C(O)Rb7, C(O)NRc7Rd7, C(O)ORa7, OC(O)Rb7, OC(O)NRc7Rd7, NRc7Rd7, NRc7C(O)Rb7, NRc7C(O)NRc7Rd7, NRc7C(O)ORa7, C(?NRe7)NRc7Rd7, NRc7C(?NRe7)NRc7Rd7, S(O)Rb7, S(O)NRc7Rd7, S(O)2Rb7, NRc7S(O)2Rb7, NR7S(O)2NRc7Rd7, and S(O)2NRc7Rd7, wherein said C1-6 alkyl, C3-7 cycloalkyl, 4-7 membered heterocycloalkyl, phenyl, and 5-6 membered heteroaryl are each optionally substituted by 1, 2, or 3 substituents independently selected from halo, C1-4 alkyl, C1-4 haloalkyl, C1-4 cyanoalkyl, CN, ORa7, SRa7, C(O)Rb7, C(O)NRc7Rd7, C(O)ORa7, OC(O)Rb7, OC(O)NRc7Rd7, NRc7Rd7, NRc7C(O)Rb7, NRc7C(O)NRc7Rd7, NRc7C(O)ORa7, C(?NRe7)NRc7Rd7, NRc7C(?NRe7)NRc7Rd7, S(O)Rb7, S(O)NRc7Rd7, S(O)2Rb7, NRc7S(O)2Rb7, NRc7S(O)2NRc7Rd7, and S(O)2NRc7Rd7;
each Ra3, Rb3, Rc3, and Rd3 is independently selected from H, C1-6 alkyl, C1-4 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C6-10 aryl, C3-10 cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C6-10 aryl-C1-4 alkyl-, C3-10 cycloalkyl-C1-4 alkyl-, (5-10 membered heteroaryl)-C1-4 alkyl-, and (4-10 membered heterocycloalkyl)-C1-4 alkyl-, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C6-10 aryl, C3-10 cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C6-10 aryl-C1-4 alkyl-, C3-10 cycloalkyl-C1-4 alkyl-, (5-10 membered heteroaryl)-C1-4 alkyl-, and (4-10 membered heterocycloalkyl)-C1-4 alkyl- are each optionally substituted with 1, 2, 3, 4, or 5 substituents independently selected from C1-4 alkyl, C1-4 haloalkyl, C1-4 cyanoalkyl, halo, CN, ORa7, SRa7, C(O)Rb7, C(O)NRc7Rd7, C(O)ORa7, OC(O)Rb7, OC(O)NRc7Rd7, NRc7Rd7, NRc7C(O)Rb7, NRc7C(O)NRc7Rd7, NRc7C(O)ORa7, C(?NRe7)NRc7Rd7, NRc7C(?NRe7)NRc7Rd7, S(O)Rb7, S(O)NRc7Rd7, S(O)2Rb7, NRc7S(O)2Rb7, NRc7S(O)2NRc7Rd7, and S(O)2NRc7Rd7;
or any Rc3 and Rd3 together with the N atom to which they are attached form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, or 3 substituents independently selected from C1-6 alkyl, C3-7 cycloalkyl, 4-7 membered heterocycloalkyl, phenyl, 5-6 membered heteroaryl, C1-6 haloalkyl, halo, CN, ORa7, SRa7, C(O)Rb7, C(O)NRc7Rd7, C(O)ORa7, OC(O)Rb7, OC(O)NRc7Rd7, NRc7Rd7, NRc7C(O)Rb7, NRc7C(O)NRc7Rd7, NRc7C(O)ORa7, C(?NRe7)NRc7Rd7, NRc7C(?NRe7)NRc7Rd7, S(O)Rb7, S(O)NRc7Rd7, S(O)2Rb7, NRc7S(O)2Rb7, NRc7S(O)2NRc7Rd7, and S(O)2NRc7Rd7, wherein said C1-6 alkyl, C3-7 cycloalkyl, 4-7 membered heterocycloalkyl, phenyl, and 5-6 membered heteroaryl are each optionally substituted by 1, 2, or 3 substituents independently selected from halo, C1-4 alkyl, C1-4 haloalkyl, C1-4 cyanoalkyl, CN, ORa7, SRa7, C(O)Rb7, C(O)NRc7Rd7, C(O)ORa7, OC(O)Rb7, OC(O)NRc7Rd7, NRc7Rd7, NRc7C(O)Rb7, NRc7C(O)NRc7Rd7, NRc7C(O)ORa7, C(?NRe7)NRc7Rd7, NRc7C(?NRe7)NRc7Rd7, S(O)Rb7, S(O)NRc7Rd7, S(O)2Rb7, NRc7S(O)2Rb7, NRc7S(O)2NRc7Rd7, and S(O)2NRc7Rd7;
each Ra4, Rb4, Rc4, and Rd4 is independently selected from H, C1-6 alkyl, C1-4 haloalkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein said C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with 1, 2, 3, 4, or 5 substituents independently selected from C1-4 alkyl, C1-4 haloalkyl, C1-4 cyanoalkyl, halo, CN, ORa7, SRa7, C(O)Rb7, C(O)NRc7Rd7, C(O)ORa7, OC(O)Rb7, OC(O)NRc7Rd7, NRc7Rd7, NRc7C(O)Rb7, NRc7C(O)NRc7Rd7, NRc7C(O)ORa7, C(?NRe7)NRc7Rd7, NRc7C(?NRe7)NRc7Rd7, S(O)Rb7, S(O)NRc7Rd7, S(O)2Rb7, NRc7S(O)2Rb7, NRc7S(O)2NRc7Rd7, and S(O)2NRc7Rd7;
or any Rc4 and Rd4 together with the N atom to which they are attached form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, or 3 substituents independently selected from C1-6 alkyl, C1-6 haloalkyl, halo, CN, ORa7, SRa7, C(O)Rb7, C(O)NRc7Rd7, C(O)ORa7, OC(O)Rb7, OC(O)NRc7Rd7, NRc7Rd7, NRc7C(O)Rb7, NRc7C(O)NRc7Rd7, NRc7C(O)ORa7, C(?NRe7)NRc7Rd7, NRc7C(?NRe7)NRc7Rd7, S(O)Rb7, S(O)NRc7Rd7, S(O)2Rb7, NRc7S(O)2Rb7, NRc7S(O)2NRc7Rd7, and S(O)2NRc7Rd7;
each Ra5, Rb5, Rc5, and Rd5 is independently selected from H, C1-6 alkyl, C1-4 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C6-10 aryl, C3-10 cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C6-10 aryl-C1-4 alkyl-, C3-10 cycloalkyl-C1-4 alkyl-, (5-10 membered heteroaryl)-C1-4 alkyl-, and (4-10 membered heterocycloalkyl)-C1-4 alkyl-, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C6-10 aryl, C3-10 cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C6-10 aryl-C1-4 alkyl-, C3-10 cycloalkyl-C1-4 alkyl-, (5-10 membered heteroaryl)-C1-4 alkyl-, and (4-10 membered heterocycloalkyl)-C1-4 alkyl- are each optionally substituted with 1, 2, 3, 4, or 5 substituents independently selected from C1-4 alkyl, C1-4 haloalkyl, C1-4 cyanoalkyl, halo, CN, ORa7, SRa7, C(O)Rb7, C(O)NRc7Rd7, C(O)ORa7, OC(O)Rb7, OC(O)NRc7Rd7, NRc7Rd7, NRc7C(O)Rb7, NRc7C(O)NRc7Rd7, NRc7C(O)ORa7, C(?NRe7)NRc7Rd7, NRc7C(?NRe7)NRc7Rd7, S(O)Rb7, S(O)NRc7Rd7, S(O)2Rb7, NRc7S(O)2Rb7, NRc7S(O)2NRc7Rd7, and S(O)2NRc7Rd7;
or any Rc5 and Rd5 together with the N atom to which they are attached form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, or 3 substituents independently selected from C1-6 alkyl, C3-7 cycloalkyl, 4-7 membered heterocycloalkyl, C6-10 aryl, 5-6 membered heteroaryl, C1-6 haloalkyl, halo, CN, ORa7, SRa7, C(O)Rb7, C(O)NRc7Rd7, C(O)ORa7, OC(O)Rb7, OC(O)NRc7Rd7, NRc7Rd7, NRc7C(O)Rb7, NRc7C(O)NRc7Rd7, NRc7C(O)ORa7, C(?NRe7)NRc7Rd7, NRc7C(?NRe7)NRc7Rd7, S(O)Rb7, S(O)NRc7Rd7, S(O)2Rb7, NRc7S(O)2Rb7, NRc7S(O)2NRc7Rd7, and S(O)2NRc7Rd7, wherein said C1-6 alkyl, C3-7 cycloalkyl, 4-7 membered heterocycloalkyl, C6-10 aryl, and 5-6 membered heteroaryl are each optionally substituted by 1, 2, or 3 substituents independently selected from halo, C1-4 alkyl, C1-4 haloalkyl, C1-4 cyanoalkyl, CN, ORa7, SRa7, C(O)Rb7, C(O)NRc7Rd7, C(O)ORa7, OC(O)Rb7, OC(O)NRc7Rd7, NRc7Rd7, NRc7C(O)Rb7, NRc7C(O)NRc7Rd7, NRc7C(O)ORa7, C(?NRe7)NRc7Rd7, NRc7C(?NRe7)NRc7Rd7, S(O)Rb7, S(O)NRc7Rd7, S(O)2Rb7, NRc7S(O)2Rb7, NRc7S(O)2NRc7Rd7, and S(O)2NRc7Rd7;
each Ra6, Rb6, Rc6, and Rd6 is independently selected from H, C1-6 alkyl, C1-4 haloalkyl, C2-6 alkenyl, and C2-6 alkynyl, wherein said C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each optionally substituted with 1, 2, 3, 4, or 5 substituents independently selected from C1-4 alkyl, C1-4 haloalkyl, C1-4 cyanoalkyl, halo, CN, ORa7, SRa7, C(O)Rb7, C(O)NRc7Rd7, C(O)ORa7, OC(O)Rb7, OC(O)NRc7Rd7, NRc7Rd7, NRc7C(O)Rb7, NRc7C(O)NRc7Rd7, NRc7C(O)ORa7, C(?NRe7)NRc7Rd7, NRc7C(?NRe7)NRc7Rd7, S(O)Rb7, S(O)NRc7Rd7, S(O)2Rb7, NRc7S(O)2Rb7, NRc7S(O)2NRc7Rd7, and S(O)2NRc7Rd7;
or any Rc6 and Rd6 together with the N atom to which they are attached form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, or 3 substituents independently selected from C1-6 alkyl, C1-6 haloalkyl, halo, CN, ORa7, SRa7, C(O)Rb7, C(O)NRc7Rd7, C(O)ORa7, OC(O)Rb7, OC(O)NRc7Rd7, NRc7Rd7, NRc7C(O)Rb7, NRc7C(O)NRc7Rd7, NRc7C(O)ORa7, C(?NRe7)NRc7Rd7, NRc7C(?NRe7)NRc7Rd7, S(O)Rb7, S(O)NRc7Rd7, S(O)2Rb7, NRc7S(O)2Rb7, NRc7S(O)2NRc7Rd7, and S(O)2NRc7Rd7;
each Ra7, Rb7, Rc7, and Rd7 is independently selected from H, C1-4 alkyl, C1-4 haloalkyl, C2-4 alkenyl, and C2-4 alkynyl, wherein said C1-4 alkyl, C2-4 alkenyl, and C2-4 alkynyl are each optionally substituted with 1, 2, or 3 substituents independently selected from OH, CN, amino, halo, C1-4 alkyl, C1-4 alkoxy, C1-4 alkylthio, C1-4 alkylamino, di(C1-4 alkyl)amino, C1-4 haloalkyl, and C1-4 haloalkoxy; and
each Re1, Re2, Re3, Re4, Re5, Re6, and Re7 is independently selected from H, C1-4 alkyl, and CN.

US Pat. No. 10,112,948

BENZAMIDE OR BENZAMINE COMPOUNDS USEFUL AS ANTICANCER AGENTS FOR THE TREATMENT OF HUMAN CANCERS

The Board of Regents of t...

1. A compound according to Formula I-g
wherein
R1 is selected from the group consisting of

n=0, 1, or 2;
m=0 or 1;
R2 and R3 can be attached at any available position on the aromatic ring and are independently selected from the group consisting of H, D, F, Cl, CF3, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 hydroxyalkyl, cycloalkyl, OR, N(R)2, NO2, N3, NH—C(O)—R, CN, C(O)R, C(O)OR, C(O)N(R)2, SR, alkylacyl, and arylacyl;
Each R is independently selected from the group consisting of H, C1-3 alkyl, propargyl, and phenyl;
R4 and R5 are independently selected from the group consisting of H, C1-6 alkyl optionally substituted with N(R)2, C2-C6 alkenyl, C2-C6 alkynyl, C1-C6 hydroxyalkyl, phenyl optionally substituted with R3, and CH2OC(O)-phenyl optionally substituted with R3;
R6 and R7 are independently selected from the group consisting of H, C1-3 alkyl, and C(O)OMe3;
such that all possible stereoisomers, including optically active isomers, are included whenever stereogenic centers are present;
or a pharmaceutically acceptable salt, prodrug, active metabolite, or solvate thereof.

US Pat. No. 10,112,946

COMPOSITION

GlaxoSmithKline LLC, Wil...

1. A pharmaceutical dosage form comprising Compound (I):or a pharmaceutically acceptable salt thereof, and means for providing a metered-dose of Compound (I), or a pharmaceutically acceptable salt thereof, which provides about 10 nanogrammes of Compound (I) per actuation of the metering means.

US Pat. No. 10,112,945

FUSED QUINOLINE COMPUNDS AS PI3K, MTOR INHIBITORS

1. A compound of formula I
wherein
Q1 and Q2 are independently selected from an aryl, a 5-6 membered heterocyclyl or a 9-11 membered bicycloheterocyclyl;
Z is N or C—R;
R and R1, when present, are independently selected from H, halogen, halogenC1-C6alkyl, —C1-C6alkyl, —OR7, —NR7R8, or are not present;
wherein when R and R1 are not present Q1 is a halogen;
R2 and R3 are independently selected from H, halogen, —OH, —C1-C6alkyl, —C1-C6alkoxyl, —C1-C6alkenyl or —C1-C6alkynyl;
R7 and R8 are independently selected from H, halogen, —C1-C6alkyl, —C1-C6alkylOH, —C1-C6alkoxyl, —C1-C6alkylNR4R5, —C(?O)C1-C6alkyl, —C(?O)C1-C6alkyl-R4R5, —C(?O)C1-C6alkylOH, —C(?O)C1-C6alkoxyl, —C(?O)C1-C6alkylNR4R5, —C(?O)OC1-C6alkyl, —C(?O)OC1-C6alkylOH, —C(?O)OC1-C6alkoxyl, —C(?O)OC1-C6alkylNR4R5, —C(?O)NR4C1-C6alkyl, —C(?O)NR4C1-C6al-kylOH, —C(?O)NR4C1-C6alkoxyl, —C(?O)NR4C1-C6alkylNR4R5;
R4 and R5 are independently selected from H, halogen, halogenC1-C6alkyl, —C1-C6alkyl, —OH, —C1-C6alkoxyl, cycloalkyl; or both R4 and R5 can be combined together to form a 3-8 membered saturated or unsaturated ring that can be aliphatic cyclyl or heterocyclyl;
or a pharmaceutically acceptable salt thereof.

US Pat. No. 10,112,939

TIED-BACK BENZAMIDE DERIVATIVES AS POTENT ROCK INHIBITORS

Bristol-Myers Squibb Comp...

1. A compound of formula (IV):
or an enantiomer, a diastereomer, a stereoisomer, or a pharmaceutically acceptable salt thereof,
wherein:
R3 is independently selected from CN, C1-4 alkyl substituted with 0-3 Re, and —ORb;
R8 is independently selected from F, C1-4 alkyl substituted with 0-3 Re, —(CH2)rORb, —(CH2)rC(?O)Rb, —NRaRa, —C(?O)NRaRa, and —C(?O)ORb;
R9 is independently selected from F, Cl, Br, C1-4 alkyl,
nitro, —S(O)pRc, —S(O)pNRaRa, —ORb, —NRaRa, —C(?O)ORb, —(CH2)rC(?O)Rb, —C(?O)NRaRa, —(CH2)r-c ycloalkyl, —(CH2)r-heterocyclyl, —(CH2)r-aryl, and —(CH2)r-heteroaryl, wherein said alkyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl is substituted with 0-4 Re;
Ra, at each occurrence, is independently selected from H, CN, C1-6 alkyl substituted with 0-5 Re, —(CH2)r—C3-6cycloalkyl substituted with 0-5 Re, —(CH2)r-aryl substituted with 0-5 Re, and —(CH2)r-heterocyclyl substituted with 0-5 Re; or Ra and Ra together with the nitrogen atom to which they are both attached form a heterocyclic ring substituted with 0-5 Re;
Rb, at each occurrence, is independently selected from H, C1-6 alkyl substituted with 0-5 Re, C2-6 alkenyl substituted with 0-5 Re, C2-6 alkynyl substituted with 0-5 Re, —(CH2)r—C3-10carbocyclyl substituted with 0-5 Re, and —(CH2)r-heterocyclyl substituted with 0-5 Re;
Rc, at each occurrence, is independently selected from C1-6 alkyl substituted with 0-5 Re, C2-6alkenyl substituted with 0-5 Re, C2-6alkynyl substituted with 0-5 Re, C3-6carbocyclyl, and heterocyclyl;
Re, at each occurrence, is independently selected from C1-6 alkyl substituted with 0-5 Rf, C2-6 alkenyl, C2-6 alkynyl, —(CH2)r—C3-6 cycloalkyl, F, Cl, Br, CN, NO2, ?O, CO2H, —(CH2)rORf, S(O)pRf, S(O)pNRfRf, and —(CH2)rNRfRf;
Rf, at each occurrence, is independently selected from H, F, Cl, Br, CN, OH, C1-5 alkyl, C3-6 cycloalkyl, and phenyl, or Rf and Rf together with the nitrogen atom to which they are both attached form a heterocyclic ring optionally substituted with C1-4alkyl;
p, at each occurrence, is independently selected from zero, 1, and 2; and
r, at each occurrence, is independently selected from zero, 1, 2, 3, and 4;
provided that R3 is not OPh.

US Pat. No. 10,112,938

INDOLIN-2-ONE AND 1,3-DIHYDRO-PYRROLO[3,2-C]PYRIDIN-2-ONE DERIVATIVES

Hoffman-La Roche Inc., L...

1. A compound of formula (I)
wherein
Ar1 is phenyl, pyridinyl or pyrimidinyl;
Ar2 is selected from the group consisting of (i), (ii), (iv), (v), (vi), (vii), (viii), (ix), (x) and (xi);

R1 is hydrogen, C1-7-alkyl, halogen or C1-7-alkoxy;
R3 is hydrogen, C1-7-alkyl, C1-7-alkyl substituted by hydroxy, cycloalkyl, oxetan-3-yl, pyridinyl, imidazolyl, pyrazolyl, pyrimidinyl, which rings may optionally substituted by C1-7-alkyl, or is (CH2)3—S(O)2-cyclopropyl;
X is CH or N;
n is 1 or 2; or,
or, a pharmaceutically acceptable salt thereof, a racemic mixture, an enantiomer, an optical isomer, a stereoisomer thereof.

US Pat. No. 10,112,934

(CYANO-DIMETHYL-METHYL)-ISOXAZOLES AND -[1,3,4]THIADIAZOLES

Centrexion Therapeutics C...

1. A method of treating pain selected from the group consisting of acute pain, visceral pain, and neuropathic pain, comprising administering to a human being an effective amount of a compound selected from the group consisting ofand a pharmaceutically acceptable salt thereof, to treat the pain.

US Pat. No. 10,112,930

COMPOSITIONS AND METHODS FOR CONTROLLING NEMATODES

Monsanto Technology LLC, ...

1. A method for control of plant parasitic nematodes, the method comprising administering to a plant, a seed or soil a composition comprising an effective amount of a compound of Formula III or a salt thereof,
wherein,
A is phenyl or pyrazyl, each of which can be optionally independently substituted with one or more substituents selected from the group consisting of halogen, CF3, CH3, OCF3, OCH3, CN and C(H)O; and
C is thienyl, furanyl, oxazolyl, or isoxazolyl, each of which can be optionally independently substituted with one or more substituents selected from the group consisting of fluorine, chlorine, CH3 and OCF3.

US Pat. No. 10,112,929

LACTAMS AS INHIBITORS OF ROCK

Bristol-Myers Squibb Comp...

1. A compound according to Formula (I):
or an enantiomer, a diastereomer, a stereoisomer, a tautomer, or a pharmaceutically acceptable salt thereof, wherein
Ring A is independently selected from

J1, J2, J3, and J4 are independently selected from N, CR3 and CR4; provided no more than two of J1, J2, J3, and J4 are N;
K is independently selected from the group consisting of N, CR1 and CR2;
L is NR6(CR7R7)m;
R1 is independently selected from the group consisting of H, F, Cl, Br, OH, CN, NRaRa, —OC1-4 alkyl substituted with 0-3 Re, and C1-4 alkyl substituted with 0-3 Re;
R2 is independently selected from the group consisting of H, F, Cl, Br, —(CH2)rORb, (CH2)rS(O)pRc, —(CH2)rC(?O)Rb, —(CH2)rNRaRa, —(CH2)rCN, —(CH2)rC(?O)NRaRa, —(CH2)rNRaC(?O)Rb, —(CH2)rNRaC(?O)NRaRa, —(CH2)NRaC(?O)ORb, —(CH2)rOC(?O)NRaRa, —(CH2)rC(?O)ORb, —(CH2)rS(O)pNRaRa, —(CH2)rNRaS(O)pNRaRa, —(CH2)rNRaS(O)pRc, (CH2)r—C3-6 carbocyclyl substituted with 0-3 Re, and —(CH2)r-heterocyclyl substituted with 0-3 Re;
R3 is independently selected from the group consisting of H, F, Cl, Br, CN, C1-4 alkyl substituted with 0-3 Re, —(CH2)rORb, (CH2)rS(O)pRc, —(CH2)rC(?O)Rb, —(CH2)rNRaRa, —(CH2)rC(?O)NRaRa, —(CH2)rC(?O)(CH2)rNRaRa, —(CH2)rCN, —(CH2)rNRaC(?O)Rb, —(CH2)rNRaC(?O)ORb, —(CH2)rOC(?O)NRaRa, —(CH2)rNRaC(?O)NRaRa, —(CH2)k(?O)ORb, —(CH2)rS(O)pNRaRa, —(CH2)rNRaS(O)pNRaRa, —(CH2)rNRaS(O)pRc, (CH2)r—C3-6 carbocyclyl substituted with 0-3 Re, and —(CH2)r-heterocyclyl substituted with 0-3 Re;
R4 is independently selected from the group consisting of H, F, Cl, Br, OH, CN, OC1-4 alkyl substituted with 0-3 Re, NRaRa, and C1-4 alkyl substituted with 0-3 Re;
R5 is independently selected from the group consisting of H, ?O, C1-4alkyl substituted with 0-4 Re, —(CH2)rORb, (CH2)rS(O)pRc, —(CH2)rC(?O)Rb, —(CH2)rNRaRa, —(CH2)rCN, —(CH2)rC(?O)NRaRa, —(CH2)rNRaC(?O)Rb, —(CH2)rNRaC(?O)NRaRa, —(CH2)rNRaC(?O)ORb, —(CH2)rOC(?O)NRaRa, —(CH2)rC(?O)ORb, —(CH2)rS(O)pNRaRa, —(CH2)rNRaS(O)pNRaRa, —(CH2)rNRaS(O)pRc, (CH2)r—C3-6 carbocyclyl substituted with 0-3 Re, and —(CH2)r-heterocyclyl substituted with 0-3 Re;
R6 is independently selected from the group consisting of H and C1-4alkyl substituted with 0-4 Re;
R7 is independently selected from H, C1-4alkyl substituted with 0-4 Re, —(CH2)rORb, —(CH2)rS(O)pRc, —(CH2)rC(?O)Rb, —(CH2)rNRaRa, —(CH2)rC(?O)NRaRa, —(CH2)rC(?O)(CH2)rNRaRa, —(CH2)rNRaC(?O)Rb, —(CH2)rNRaC(?O)ORb, —(CH2)rOC(?O)NRaRa, —(CH2)rNRaC(?O)NRaRa, —(CH2)k(?O)ORb, —(CH2)rS(O)pNRaRa, —(CH2)rNRaS(O)pNRaRa, —(CH2)rNRaS(O)pRc, (CH2)r—C3-6 carbocyclyl substituted with 0-3 Re, and —(CH2)r-heterocyclyl substituted with 0-3 Re; alternatively, R7 and R7 form ?O;
R8 is independently selected from the group consisting of C3-6 cycloalkyl, heterocyclyl, aryl and heteroaryl, each substituted with 0-5 R9;
alternatively, when m is zero, R8 and R6 together with the nitrogen atom to which they are both attached form a heterocyclic ring substituted with 0-5 R9;
R9 is independently selected from the group consisting of H, ?O, F, Cl, Br, C1-4alkyl, C2-4alkenyl, C2-4alkynyl, nitro, —(CRdRd)rS(O)pRc, —(CRdRd)rS(O)pNRaRa, —(CRdRd)rNRaS(O)pRc, —(CRdRd)rORb, —(CRdRd)rCN, —(CRdRd)rNRaRa, —(CRdRd)rNRaC(?O)Rb, —(CRdRd)rNRaC(?O)NRaRa, —(CRdRd)rNRaC(?O)ORb, —(CRdRd)rC(?O)ORb, —(CRdRd)rC(?O)NRaRa, —(CRdRd)rC(?O)Rb, —(CRdRd)rOC(?O)Rb, —(CRdRd)rOC(?O)NRaRa, —(CRdRd)r-cycloalkyl, —(CRdRd)r-heterocyclyl, —(CRdRd)r-aryl, and —(CRdRd)r-heteroaryl, wherein said alkyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl is substituted with 0-4 Re;
Ra, at each occurrence, is independently selected from the group consisting of H, C1-6 alkyl substituted with 0-5 Re, C2-6 alkenyl substituted with 0-5 Re, C2-6 alkynyl substituted with 0-5 Re, —(CH2)r—C3-10carbocyclyl substituted with 0-5 Re, and —(CH2)r-heterocyclyl substituted with 0-5 Re; or Ra and Ra together with the nitrogen atom to which they are both attached form a heterocyclic ring substituted with 0-5 Re;
Rb, at each occurrence, is independently selected from the group consisting of H, C1-6 alkyl substituted with 0-5 Re, C2-6 alkenyl substituted with 0-5 Re, C2-6 alkynyl substituted with 0-5 Re, —(CH2)r—C3-10carbocyclyl substituted with 0-5 Re, and —(CH2)r-heterocyclyl substituted with 0-5 Re;
Rc, at each occurrence, is independently selected from the group consisting of C1-6 alkyl substituted with 0-5 Re, C2-6alkenyl substituted with 0-5 Re, C2-6alkynyl substituted with 0-5 Re, C3-6carbocyclyl, and heterocyclyl;
Rd, at each occurrence, is independently selected from the group consisting of H and C1-4alkyl substituted with 0-5 Re;
Re, at each occurrence, is independently selected from the group consisting of C1-6 alkyl substituted with 0-5 Rf, C2-6 alkenyl, C2-6 alkynyl, —(CH2)r—C3-6 cycloalkyl, —(CH2)r—C4-6 heterocyclyl, —(CH2)r-aryl, —(CH2)r-heteroaryl, F, Cl, Br, CN, NO2, ?O, CO2H, —(CH2)rORf, S(O)pRf, C(?O)NRfRf, NRfC(?O)Rd, S(O)pNRfRf, NRfS(O)pRd, NRfC(?O)ORd, OC(?O)NRfRf and —(CH2)rNRfRf;
Rf, at each occurrence, is independently selected from the group consisting of H, F, Cl, Br, CN, OH, C1-5alkyl, C3-6 cycloalkyl, and phenyl; or Rf and Rf together with the nitrogen atom to which they are both attached form a heterocyclic ring optionally substituted with C1-4alkyl;
m is independently selected from zero, 1, and 2;
p, at each occurrence, is independently selected from zero, 1, and 2; and
r, at each occurrence, is independently selected from zero, 1, 2, 3, and 4.

US Pat. No. 10,112,928

INHIBITORS OF SYK

HOFFMANN-LA ROCHE INC., ...

1. A compound of Formula I
wherein:
R1 is —OR1? or (CH2)nR1?;
R1? is phenyl, pyridyl, cycloalkyl, amino cycloalkyl C1-6 alkyl or C1-6 alkyl, optionally substituted with one or more R1?;
each R1? is independently cyano, amino, amino C1-6 alkyl, halo, C1-6 alkyl, cycloalkyl, or amino cycloalkyl C1-6 alkyl;
R2 is C1-6 alkyl, cycloalkyl, cyano C1-6 alkyl, hydroxy C1-6 alkyl, halo C1-6 alkyl, dialkyl amino, or C1-6 alkoxy;
R3 is absent;
R4 is H or C1-6 alkyl;
X1 is CH or N;
X2 is CH, CR2 or N;
X3 is CH or N;
Y1 is N; and
Y2 is N;
Y3 is CH; and
n is 0 or 1;
or a pharmaceutically acceptable salt thereof.

US Pat. No. 10,112,927

INHIBITORS OF CYCLIN-DEPENDENT KINASE 7 (CDK7)

Dana-Farber Cancer Instit...

1. A compound of Formula (I):or a pharmaceutically acceptable salt thereof;wherein:Ring A is

each instance of RA1 is independently selected from the group consisting of hydrogen and alkyl;
each instance of RA2 is independently selected from the group consisting of hydrogen, halogen, alkyl, aryl, and heteroaryl;
Ring B is of the formula:

RB1 is selected from the group consisting of hydrogen and alkyl,
WB is CRB2, wherein RB2 is selected from the group consisting of hydrogen, cyano, halogen, optionally substituted alkyl, carbocyclyl, and ORB2a,
wherein RB2a is selected from the group consisting of hydrogen and alkyl;
or RB1 and RB2 are joined to form a carbocyclyl or aryl ring;
X is NRX—, wherein RX is hydrogen or C1-6 alkyl;
L2 is —NRL2aC(?O)— or —NRL2aS(?O)2—, wherein RL2a is hydrogen or C1-6 alkyl;
each instance of RC is independently selected from the group consisting of hydrogen, halogen, and alkyl;
n is 0, 1, 2, 3, or 4;
each instance of RD is independently selected from the group consisting of hydrogen, halogen, alkyl, and —N(RD1)2,
wherein each occurrence of RD1 is independently selected from the group consisting of hydrogen and alkyl;
p is 0, 1, 2, 3, or 4;
RE is

RE and L2 are para or meta to each other;
L3 is —NRL3a— or an optionally substituted C1-4 hydrocarbon chain, wherein RL3a is hydrogen;
RE1 is selected from the group consisting of hydrogen and alkyl;
RE2 is hydrogen or alkyl;
RE3 is selected from the group consisting of hydrogen, alkyl, —CH2ORE3a, and —CH2N(RE3a)2,
wherein each occurrence of RE3a is independently selected from the group consisting of hydrogen, alkyl,

 and alkynyl; and
Y is O;
wherein “substituted” within each of RB2 and L3, refers independently to halogen, cyano, —NO2, —OH, —ORaa, —N(Rbb)2, —SH, —SRaa,—C(?O)Raa, —CO2H, —CHO, —CO2Raa, —OC(?O)Raa, —OCO2Raa, —C(?O)N(Rbb)2, —OC(?O)N(Rbb)2, —NRbbC(?O)Raa, —NRbbCO2Raa, —NRbbC(?O)N(Rbb)2, —C(?NRbb)Raa,—C(?NRbb)N(Rbb)2,—NRbbC(?NRbb)N(Rbb)2;
each of Raa is independently alkyl; and
each of Rbb is independently hydrogen or alkyl.

US Pat. No. 10,112,917

THERAPEUTIC COMPOUNDS

ARIZONA BOARD OF REGENTS ...

1. A compound of formula (I), or a salt thereof:wherein:R1 is H or (C1-C6)alkyl;
the bond represented by ---- is a single bond or a double bond;
ring A is optionally substituted with one or more groups independently selected from halo, hydroxy, nitro, cyano, —NRaRb, (C1-C6)alkyl, (C2-C6)alkenyl, (C2-C6)alkynyl, (C3-C6)cycloalkyl, (C1-C6)alkoxy, (C1-C6)alkoxycarbonyl, and (C1-C6)alkanoyloxy, wherein each (C1-C6)alkyl, (C2-C6)alkenyl, (C2-C6)alkynyl, (C3-C6)cycloalkyl, (C1-C6)alkoxy, (C1-C6)alkoxycarbonyl, and (C1-C6)alkanoyloxy, is optionally substituted with one or more groups independently selected from halo, hydroxy, nitro, cyano, (C1-C6)alkoxy, —NRaRb, and oxo (?O); and
Ra and Rb are each independently H or (C1-C6)alkyl; or Ra and Rb taken together with the nitrogen to which they are attached form a ring selected from aziridine, azetidino, pyrrolidino, and morpholino.

US Pat. No. 10,112,915

3-ARYL BICYCLIC [4,5,0] HYDROXAMIC ACIDS AS HDAC INHIBITORS

Forma Therapeutics, Inc.,...

1. A compound of Formula I:
or a pharmaceutically acceptable salt, hydrate, tautomer or isomer thereof,wherein:X1 is O;
X2 and X4 are each CR1R2;
X3 is CR1?R2?;
Y1 and Y4 are not bonded to —C(O)NHOH and are each CR1;
Y2 and Y3 are each CR1 when not bonded to —C(O)NHOH and Y2 and Y3 are C when bonded to —C(O)NHOH;
L is selected from the group consisting of a bond, —(CR1R2)n—, —C(O)O—, —C(O)NR3—, —S(O)2—, —S(O)2NR3—, —S(O)—, and —S(O)NR3—, wherein L is bound to the ring nitrogen through the carbonyl or sulfonyl group;
R is independently selected from the group consisting of —H, —C1-C6 alkyl, —C2-C6 alkenyl, —C4-C8 cycloalkenyl, —C2-C6 alkynyl, —C3-C8 cycloalkyl, —C5-C12 spirocycle, heterocyclyl, spiroheterocyclyl, aryl, and heteroaryl containing 1 to 5 heteroatoms selected from the group consisting of N, S, P, and O, wherein each alkyl, alkenyl, cycloalkenyl, alkynyl, cycloalkyl, spirocycle, heterocyclyl, spiroheterocyclyl, aryl, or heteroaryl is optionally substituted with one or more substituents selected from the group consisting of —OH, halogen, oxo, —NO2, —CN, —R1, —R2, —OR3, —NHR3, —NR3R4, —S(O)2NR3R4, —S(O)2R1, —C(O)R1, —CO2R1, —NR3S(O)2R1, —S(O)R1, —S(O)NR3R4, —NR3S(O)R1, heterocycle, aryl, and heteroaryl containing 1 to 5 heteroatoms selected from the group consisting of N, S, P, and O;
each R1 and R2 are independently, and at each occurrence, selected from the group consisting of —H, —R3, —R4, —C1-C6 alkyl, —C2-C6 alkenyl, —C4-C8 cycloalkenyl, —C2-C6 alkynyl, —C3-C8 cycloalkyl, heterocyclyl, aryl, heteroaryl containing 1 to 5 heteroatoms selected from the group consisting of N, S, P, and O, —OH, halogen, —NO2, —CN, —NHC1-C6 alkyl, —N(C1-C6 alkyl)2, —S(O)2N(C1-C6 alkyl)2, —N(C1-C6 alkyl)S(O)2R5, —S(O)2(C1-C6 alkyl), —(C1-C6 alkyl)S(O)2R5, —C(O)C1-C6 alkyl, —CO2C1-C6 alkyl, —N(C1-C6 alkyl)S(O)2C1-C6 alkyl, and —(CHR5)nNR3R4, wherein each alkyl, alkenyl, cycloalkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl is optionally substituted with one or more substituents selected from the group consisting of —OH, halogen, —NO2, oxo, —CN, —R5, —OR3, —NHR3, NR3R4, —S(O)2N(R3)2, —S(O)2R5, —C(O)R5, —CO2R5, —NR3S(O)2R5, —S(O)R5, —S(O)NR3R4, —NR3S(O)R5, heterocycle, aryl, and heteroaryl containing 1 to 5 heteroatoms selected from the group consisting of N, S, P, and O;
R1? and R2? are independently, and at each occurrence, selected from the group consisting of H, aryl, and heteroaryl containing 1 to 5 heteroatoms selected from the group consisting of N, S, P, and O, wherein each aryl or heteroaryl is optionally substituted with one or more substituents selected from the group consisting of —OH, halogen, —NO2, oxo, —CN, —R3, —R5, —OR3, —NHR3, —NR3R4, —S(O)2N(R3)2, —S(O)2R5, —C(O)R5, —CO2R5, —NR3S(O)2R5, —S(O)R5, —S(O)NR3R4, —NR3S(O)R5, heterocycle, aryl, and heteroaryl containing 1 to 5 heteroatoms selected from the group consisting of N, S, P, and O, wherein at least one of R1? or R2? is not H;
R3 and R4 are independently, and at each occurrence, selected from the group consisting of —H, —C1-C6 alkyl, —C2-C6 alkenyl, —C4-C8 cycloalkenyl, —C2-C6 alkynyl, —C3-C8 cycloalkyl, heterocyclyl, aryl, heteroaryl containing 1 to 5 heteroatoms selected from the group consisting of N, S, P, and O, —S(O)2N(C1-C6 alkyl)2, —S(O)2(C1-C6 alkyl), —(C1-C6 alkyl)S(O)2R5, —C(O)C1-C6 alkyl, —CO2C1-C6 alkyl, and —(CHR5)nN(C1-C6 alkyl)2, wherein each alkyl, alkenyl, cycloalkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl is optionally substituted with one or more substituents selected from the group consisting of —OH, halogen, —NO2, oxo, —CN, —R5, —O(C1-C6) alkyl, —NH(C1-C6) alkyl, —N(C1-C6 alkyl)2, —S(O)2N(C1-C6 alkyl)2, —S(O)2NHC1-C6 alkyl, —C(O)C1-C6 alkyl, —CO2C1-C6 alkyl, —N(C1-C6 alkyl)S(O)2C1-C6 alkyl, —S(O)R5, —S(O)N(C1-C6 alkyl)2, —N(C1-C6 alkyl)S(O)R5, heterocycle, aryl, and heteroaryl containing 1 to 5 heteroatoms selected from the group consisting of N, S, P, and O;
or R3 and R can combine with the nitrogen atom to which they are attached to form a heterocycle or heteroaryl containing 1 to 5 heteroatoms selected from the group consisting of N, S, P, and O, wherein each heterocycle or heteroaryl is optionally substituted with —R4, —OR4, or —NR4R5;
R5 is independently, and at each occurrence, selected from the group consisting of —H, —C1-C6 alkyl, —C2-C6 alkenyl, —C4-C8 cycloalkenyl, —C2-C6 alkynyl, —C3-C8 cycloalkyl, heterocyclyl, aryl, heteroaryl containing 1 to 5 heteroatoms selected from the group consisting of N, S, P, and O, —OH, halogen, —NO2, —CN, —NHC1-C6 alkyl, —N(C1-C6 alkyl)2, —S(O)2NH(C1-C6 alkyl), —S(O)2N(C1-C6 alkyl)2, —S(O)2C1-C6 alkyl, —C(O)C1-C6 alkyl, —CO2C1-C6 alkyl, —N(C1-C6 alkyl)SO2C1-C6 alkyl, —S(O)(C1-C6 alkyl), —S(O)N(C1-C6 alkyl)2, —N(C1-C6 alkyl)S(O)(C1-C6 alkyl), and —(CH2)nN(C1-C6 alkyl)2; and
each n is independently and at each occurrence an integer from 0 to 6.

US Pat. No. 10,112,913

SUBSTITUTED [1,2,4]TRIAZOLE AND IMIDAZOLE COMPOUNDS AS FUNGICIDES

BASF SE, Ludwigshafen (D...

1. A compound of the formula I
wherein
A is CH or N;
R1 is C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl or C3-C6-cycloalkyl;
wherein the aliphatic moieties of R1 are not further substituted or carry one, two, three or up to the maximum possible number of identical or different groups R1a which independently of one another are selected from:
R1a halogen, OH, CN, C1-C4-alkoxy, C3-C6-cycloalkyl, C3-C6-halogencycloalkyl and C1-C4-halogenalkoxy;
wherein the cycloalkyl moieties of R1 are not further substituted or carry one, two, three, four, five or up to the maximum number of identical or different groups R1b which independently of one another are selected from:
R1b halogen, OH, CN, C1-C4-alkoxy, C1-C4-halogenalkyl, C3-C6-cycloalkyl, C3-C6-halogencycloalkyl and C1-C4-halogenalkoxy;
R2 is hydrogen, C1-C4-alkyl, C2-C4-alkenyl or C2-C4-alkynyl;
wherein the aliphatic moieties of R2 are not further substituted or carry one, two, three or up to the maximum possible number of identical or different groups R2a which independently of one another are selected from:
R2a halogen, OH, CN, C1-C4-alkoxy, C3-C6-cycloalkyl, C3-C6-halogencycloalkyl and C1-C4-halogenalkoxy;
R3 is selected from halogen, CN, C1-C4-alkyl, C1-C4-alkoxy, C2-C4-alkenyl, C2-C4-alkynyl, C3-C6-cycloalkyl and S(O)p(C1-C4-alkyl), wherein each of R3 is unsubstituted or further substituted by one, two, three or four R1a; wherein
R3a is independently selected from halogen, CN, OH, C1-C4-alkyl, C1-C4-halogenalkyl, C3-C6-cycloalkyl, C3-C6-halogencycloalkyl, C1-C4-alkoxy and C1-C4-halogenalkoxy;
p is 0, 1 or 2;
Z is CN, Si(C1-C4-alkyl)3, C1-C6-alkoxy or C(?O)—O—(C1-C6-alkyl);
wherein the aliphatic moieties of Z are not further substituted or carry one, two, three or four identical or different groups RZ, which independently of one another are selected from
RZ halogen, CN, OH, C1-C4-alkyl, C1-C4-halogenalkyl, C3-C6-cycloalkyl, C3-C6-halogencycloalkyl, O—C6H5, C1-C4-alkoxy and C1-C4-halogenalkoxy;
and the N-oxides and the agriculturally acceptable salts thereof.

US Pat. No. 10,112,911

SUBSTITUTED CYANOGUANIDINES AS ORAL ANTI-VIRALS

ABBVIE INC., North Chica...

3. A pharmaceutical composition comprising the compound of claim 1, or a pharmaceutically acceptable salt thereof, and one or more excipients, and optionally one or more additional therapeutic agents.

US Pat. No. 10,112,908

METHODS FOR PRODUCING OPTICALLY ACTIVE VALERIC ACID DERIVATIVES

DAICHI SANKYO COMPANY, LI...

1. A method of producing a compound of formula (4):
comprising allowing a compound of formula (1):
to react with hydrogen gas, in an inert solvent, in the presence of a chiral ligand of formula (2) or (3):orand a ruthenium catalyst, or in the presence of an asymmetric transition metal complex catalyst previously generated from the chiral ligand and the ruthenium catalyst,wherein R is a protective group for the carboxy group or a hydrogen atom,
R1 and R2 are each independently a hydrogen atom or a protective group for the amino group,
Ar is a phenyl group, a 3,5-dimethylphenyl group or a 4-methylphenyl group, and
Ar? is a phenyl group, a 3,5-dimethylphenyl group or a 3,5-di-tert-butyl-4-methoxyphenyl group.

US Pat. No. 10,112,895

ANTIVIRALS AGAINST MOLLUSCUM CONTAGIOSUM VIRUS

The Trustees of the Unive...

1. A compound of formula (X) or (XII):wherein:Y is heteroaryl; which is substituted with at least one group selected from the group consisting of phenyl and heteroaryl;
R1, R2, R3, R4, R5, R6, R7, R8, and R9 are independently selected from the group consisting of H, C1-C6 alkyl, halo, cyano, nitro, SO2NH2, C1-C6 haloalkyl, ORa, SRa, NRmRn, NRaCORb, SORb, SO2Rb, CORb, COORa, aryl, heteroaryl, C3-C7 cycloalkyl, 3-7 membered heterocycloalkyl, cycloalkylalkyl, heterocycloalkylalkyl, arylalkyl, and heteroarylalkyl; or two adjacent ORa or NRmRn groups, together with the atoms to which they are attached, form a 5-7 membered heterocycloalkyl group;
R14 is H, C1-C3 alkyl, C(O)ORa, C(O)Rb, C(O)NRmRn, SORb, or SO2Rb;
Ra and Rb are each independently selected from the group consisting of H, C1-6 alkyl, C1-6 haloalkyl, C2-C6 alkenyl, C2-C6 alkynyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, cycloalkylalkyl, heterocycloalkylalkyl, arylalkyl, and heteroarylalkyl;
Rm and Rn are independently selected from the group consisting of H, C1-C6 alkyl, cycloalkyl, cycloalkylalkyl, heterocycloalkylalkyl, arylalkyl, and heteroarylalkyl; or Rm and Rn, together with the nitrogen atom to which they are attached, form a 3-7 membered heterocycloalkyl group;
each occurrence of aryl is independently selected from the group consisting of phenyl and naphthyl; and
each occurrence of heteroaryl is independently selected from the group consisting of pyridine, pyrimidine, pyrazine, indole, indolizine, benzimidazole, 1,3-dihydrobenzimidazol-2-one, and indazole.

US Pat. No. 10,112,894

CYCLIC PROCESS FOR PRODUCING TAURINE

VITAWORKS IP, LLC, North...

1. A process for producing taurine from aziridine, comprising:(a) adding gaseous aziridine or a solution of aziridine to a solution of ammonium bisulfite, or ammonium sulfite, or a mixture of ammonium bisulfite and ammonium sulfite to undergo a ring-opening reaction of aziridine to form ammonium taurinate;
(b) decomposing ammonium taurinate to taurine and ammonia by heating and removing ammonia to obtain a crystalline suspension of taurine; and
(c) separating taurine by means of solid-liquid separation to provide a mother liquor.

US Pat. No. 10,112,887

CATALYSTS BASED ON AMINO-SULFIDE LIGANDS FOR HYDROGENATION AND DEHYDROGENATION PROCESSES

1. A metal complex of Formula II and IIIM(SN)pZa  II
M(SNS)Za  IIIwherein:each Z is simultaneously or independently a hydrogen or halogen atom, a C1-C6 alkyl, a carbene group, a hydroxyl group, or a C1-C7 alkoxy radical, a nitrosyl (NO) group, CO, CNR (R=Alkyl, Aryl), nitrile, phosphite, phosphinite, or phosphine;
M is a group 7, group 8, or group 9 transition metal;
p is equal to 1 or 2, whereas a is equal to 1, 2, or 3;
SN is a bidentate coordinated ligand of Formula IA, wherein the coordinating groups of the SN ligand consist of one thio group and one nitrogen group;
SNS is a tridentate coordinated ligand of Formula IB, wherein the coordinating groups of the SNS ligand consist of two thio groups and one nitrogen group:
wherethe dotted lines simultaneously or independently indicate single or double bonds;
R1, R2, R5, and R6 are each independently H, a substituted or unsubstituted linear or branched C1-C20 alkyl, a substituted or unsubstituted cyclic C3-C8 alkyl, or a substituted or unsubstituted C2-C20 alkenyl, a substituted or unsubstituted C5-C20 aryl, OR or NR2; or when taken together, R1 and R2 groups or R5 and R6 groups can form a saturated or partially saturated C5-C20 cycle;
R3 and R4 are each independently H, a substituted or unsubstituted linear, branched or cyclic C1-C8 alkyl or alkenyl, a substituted or unsubstituted C5-C8 aromatic group, ester group; or, when taken together, R3 and R4 can form an optionally substituted saturated or partially saturated C5-C20 hetero-aromatic ring;
R5 when taken together with R4 can form an optionally substituted saturated or partially saturated C5-C20 aromatic ring;
R7 is H, a substituted or unsubstituted linear or branched C1-C8 alkyl, a substituted or unsubstituted cyclic C3-C8 alkyl, a substituted or unsubstituted C2-C20 alkenyl, or a substituted or unsubstituted C5-C20 aryl; and
n, m, and q are simultaneously or independently 0, 1, or 2.

US Pat. No. 10,112,886

METHOD FOR PURIFICATION OF BENZOIC ACID

Sulzer Chemtech AG, Wint...

1. A method for purifying a crude benzoic acid stream containing 5 to 20% by weight of byproducts and 80 to 95% by weight of benzoic acid, by means of distillation, the method comprising delivering the crude benzoic acid stream to a plant comprising a first distillation system, wherein the first distillation system comprises a divided wall column, thereby providing a purified benzoic acid stream.

US Pat. No. 10,112,884

ASYMMETRICAL HYDROGENATION REACTION OF KETONIC ACID COMPOUND

1. A preparation method of the structure of formula B,
Wherein R1 is a phenyl, a substituted phenyl, a naphthyl, a substituted naphthyl, a C1-C6 alkyl or aralkyl, the substitute is a C1-C6alkyl, a C1-C6 alkoxy, a halogen, the number of the substituents is 1-3
Wherein M is the following structure chiral spiro-pyridylamidophosphine ligand iridium complex:

Wherein R is hydrogen, 3-methyl, 4-tBu or 6-methyl,
The said base is selected from sodium hydroxide, potassium hydroxide, sodium tert-butyl oxide or potassium test-butyl oxide,
The molar dosage ratio of the said base to the substrate A compound is (1.0˜3):1.

US Pat. No. 10,112,876

PROCESS FOR OLIGOMERIZATION OF ETHYLENE

SAUDI BASIC INDUSTRIES CO...

1. A process for oligomerizing ethylene, comprising:a) oligomerizing ethylene in a reactor in the presence of a solvent and a catalyst;
b) transferring a reactor overhead effluent from the reactor to an externally located cooling device to condense a portion of the reactor overhead effluent and recycling the condensed portion of the reactor overhead effluent into the reactor;
c) recovering a reactor bottom effluent from the reactor, wherein the reactor bottom effluent comprises C4 hydrocarbons, C6 hydrocarbons, C8 hydrocarbons, C10 hydrocarbons, residual C12+ hydrocarbons, residual spent catalyst, and residual polymer material;
d) transferring the reactor bottom effluent to a quenching unit, wherein quench media is added to the reactor bottom effluent, to produce a quenched reactor bottom effluent;
e) transferring the quenched reactor bottom effluent to a series of fractionation columns and, in the following order,
i) optionally separating a fraction comprising the C4 hydrocarbons from the quenched reactor bottom effluent;
ii) separating a fraction comprising the C6 hydrocarbons from the quenched reactor bottom effluent;
iii) separating a fraction comprising both the C8 hydrocarbons and C10 hydrocarbons from the quenched reactor bottom effluent and recycling said fraction comprising both the C8 hydrocarbons and C10 hydrocarbons into the reactor, and
iv) separating the residual C12+ hydrocarbons, the residual spent catalyst, the residual polymer material, and residual quench media from the quenched reactor bottom effluent,
wherein the solvent is separated from the quenched reactor bottom effluent in any of steps i)-iv) and/or in an additional step.

US Pat. No. 10,112,863

FLOAT GLASS AND METHOD OF MANUFACTURING THE SAME

SAMSUNG DISPLAY CO., LTD....

1. A float glass comprising:a core layer;
an upper ion exchange layer disposed on the core layer; and
a lower ion exchange layer disposed below the core layer,
wherein a density of the upper ion exchange layer is about 0.001 kilogram per cubic meter to about 0.01 kilogram per cubic meter greater than a density of the lower ion exchange layer, and
wherein a difference between a depth of layer of the upper ion exchange layer and a depth of layer of the lower ion exchange layer ranges from about 0.01 micrometer to about 1.0 micrometer.

US Pat. No. 10,112,862

APPARATUS AND METHOD OF MANUFACTURING COMPOSITE GLASS ARTICLES

CORNING INCORPORATED, Co...

1. A method comprising:supplying a conjoined molten glass stream to an overflow distributor, a cross-section of the conjoined molten glass stream comprising a first cross-sectional portion and a second cross-sectional portion, the first cross-sectional portion comprising a first glass composition, the second cross-sectional portion comprising a second glass composition different than the first glass composition;
flowing the first glass composition over a first transverse segment of a weir of the overflow distributor; and
flowing the second glass composition over a second transverse segment of the weir of the overflow distributor,
wherein at least one of the first transverse segment of the weir or the second transverse segment of the weir comprises less than an entire effective width of the weir.

US Pat. No. 10,112,857

METHOD AND EQUIPMENT FOR THE BIOLOGICAL DENITRIFICATION OF WASTE WATER

DEGREMONT, Paris la Defe...

1. A method for the biological denitrification of wastewater that comprises a nitrification step followed by a denitrification step, for a first fraction of the water, by a post-denitrification step during which an electron donor is injected into this first fraction, whereas a second fraction of the water passes through a bypass, and then is mixed with the first fraction downstream of the post-denitrification step, wherein:the first fraction of the wastewater is submitted, during post-denitrification, to almost complete denitrification in order to exit the step with a concentration of nitrates [N—NO3] below 4 mg/L, to minimize the production of nitrous oxide N2O,
and the bypass rate is determined from:
measurement of the concentration of nitrates [N—NO3] in the water upstream of post-denitrification,
the desired concentration of nitrates [N—NO3] for the mixture of the two fractions downstream of the post-denitrification treatment,
and the concentration of nitrates [N—NO3] in the first fraction at outlet from post-denitrification, before mixing the two fractions.

US Pat. No. 10,112,852

RDPREHEATING WATER JACKETS

RDP Technologies, Inc., ...

1. An apparatus for producing slaked lime slurry comprising:a programmable control system;
a slaking vessel having at least one support location that is provided with at least one load cell, wherein the load cell provides a load cell signal indicative of a total weight of the slaking vessel and its contents, said load cell communicating with said programmable control system such that said load cell signal can be received by said programmable control system;
slaking vessel temperature sensing means for sensing the temperature of the contents of said slaking vessel, wherein said slaking vessel temperature sensing means provides a slaking vessel temperature signal indicative of the temperature of the contents of said slaking vessel, said slaking vessel temperature sensing means communicating with said programmable control system such that said slaking vessel temperature signal can be received by said programmable control system;
means for charging water into the slaking vessel, said programmable control system communicating with said means for charging water into the slaking vessel, said programmable control system stopping the charging of water into said slaking vessel when said load cell signal indicates that a predetermined weight of water has been charged into said slaking vessel, wherein the water charged into said slaking vessel has a temperature;
means for mixing the content of said slaking vessel;
water temperature control means for controlling the temperature of the water charged into said slaking vessel, said water temperature control means communicating with said programmable control system, said programmable control system controlling said water temperature control means such that the temperature of the water charged into said slaking vessel is within a predetermined water temperature range;
means for charging lime feed stock into the slaking vessel, said programmable control system communicating with said means for charging lime feed stock into the slaking vessel, said programmable control system stopping the charging of lime feed stock into said slaking vessel when said load cell signal indicates that a predetermined weight of lime feed stock has been charged into said slaking vessel, thereby allowing a slaking reaction to take place; and
means for discharging the contents of said slaking vessel; said programmable control system communicating with said means for discharging the contents of said slaking vessel, said programmable control system monitoring the temperature of the contents of said slaking vessel using said slaking vessel temperature signal, said programmable control system operating said means for discharging the contents of said slaking vessel to discharge the contents of said slaking vessel when the temperature of the contents of said slaking vessel remains within a predetermined temperature range for a predetermined period of time.

US Pat. No. 10,112,850

SYSTEM TO REDUCE INTERFACE EMULSION LAYER FORMATION IN AN ELECTROSTATIC DEHYDRATOR OR DESALTER VESSEL THROUGH USE OF A LOW VOLTAGE ELECTROSTATIC INTERFACE EMULSION TREATMENT SYSTEM INSIDE THE VESSEL

Cameron Solutions, Inc., ...

1. A system for reducing interface emulsion layer formation when separating the components of an incoming oil-water mixture, the system comprising:a separator vessel including
an oil/water interface location including a water/emulsion boundary location;
a first set of vertically oriented electrodes located in an upper half of the vessel and connected to a high voltage power source greater than 5 kV;
a second set of vertically oriented electrodes located entirely below the first set and above the water/emulsion boundary and connected to a low voltage power source in a range of 1 kV to 5 kV, a portion of the second set being within the oil/water interface location.

US Pat. No. 10,112,849

SYSTEM AND METHOD FOR TREATING CONTAMINATED WASTEWATER

Robert Bosch GmbH, Stutt...

1. A system for treating contaminated wastewater from a buffer tank (1), comprising a feed line (3) that leads into a separator (5) and a discharge line (10) that leaves the separator (5), wherein the discharge line (10) leads into a working tank (11), wherein an access line (16) extends from the working tank (11) into a filtration system (18) which has a permeate outlet line (19) and a concentrate outlet line (17), wherein the buffer tank (1) is connected to the feed line (3) via an inlet check valve (2), wherein the permeate outlet line (19) is connected to the feed line (3) in a controllable manner in order to feed permeate back to the feed line (3), wherein the working tank (11) is connected to the feed line (3) via a return line (13), wherein a return check valve (12) is arranged in the return line (13), wherein the concentrate outlet line (17) extends from the filtration system (18) and into the working tank (11), wherein the permeate outlet line (19) is connected to the working tank (11) via a return flow line (26), wherein the system includes a heavy metal analyzer (22) in communication with the permeate outlet line (19), and wherein a precipitant line (14) opens into the feed line (3) downstream of the return line (13).

US Pat. No. 10,112,847

METHOD AND APPARATUS FOR TREATING LIQUID CONTAINING IMPURITIES

PARKSON CORPORATION, For...

1. An apparatus for treating a liquid containing impurities, comprising:a filtering chamber for receiving liquid containing impurities, the filtering chamber including a lower portion containing granular media and configured to permit the granular media to interact with the liquid containing impurities, thereby removing impurities from the liquid to produce filtrate;
a filtrate section in fluid communication with the filtering chamber for receiving the filtrate, the filtrate section being in fluid communication with a first outlet for outflow of the filtrate;
a gas supplying system for delivering gas to the granular media in the filtering chamber for transport of a portion of the granular media to a granular media washer;
a reject section in fluid communication with the granular media washer for receiving a reject mixture comprising liquid and impurities from the granular media washer, the reject section being in fluid communication with a second outlet for outflow of a portion of the reject mixture; and
a control unit that is configured to determine a condition of transport of the portion of the granular media by determining whether a level of reject mixture in the reject section exceeds a predetermined threshold,
wherein, upon determining that the level of reject mixture in the reject section exceeds the predetermined threshold, the control unit is configured to send a command signal to the gas supplying system to control delivery of gas to the portion of the granular media.