US Pat. No. 10,335,518

CATHETER LOCKING FORMULATION AND METHOD TO PREPARE SAME

1. A method to prepare a catheter locking formulation, comprising the following steps in the following order:dissolving trimethoprim in propylene glycol at a temperature between about 50° C. and about 55° C. with stirring for at least 60 minutes to form a solution of trimethoprim and propylene glycol;
sequentially adding at a temperature between about 50° C. and about 55° C., in the following order, phosphate buffered saline, EDTA Calcium Disodium Hydrate, and glycerin, to said trimethoprim/propylene glycol solution, wherein glycerin should be added only after all solids have been completely solubilized;
cooling said propylene glycol solution containing trimethoprim, propylene glycol, phosphate buffered saline, EDTA Calcium Disodium Hydrate, and glycerin to about room temperature;
adding absolute ethanol at about room temperature to a room temperature solution of trimethoprim, propylene glycol, EDTA Calcium Disodium Hydrate, phosphate buffered saline, and glycerin to form a catheter locking solution;
wherein said absolute alcohol is present at a level of at least fifteen (15) weight percent of said catheter locking solution;
wherein said catheter locking solution maintains shelf life stability, including no formation of precipitates, at temperatures between 0° C. to about 42° C. for at least three days; and
wherein said catheter locking solution comprises a pH between about 8 and about 9.

US Pat. No. 10,335,513

HYDROPHILIZATION AND ANTIFOULING OF ENHANCED METAL SURFACES

Cardiac Pacemakers, Inc.,...

1. A method for coating a roughened titanium surface of an implantable medical device, the method comprising:providing a material with a roughened titanium metal surface;
activating at least a portion of the roughened titanium surface with an oxygen containing plasma, wherein the activating step forms hydroxyl groups on the titanium surface; and
treating the activated roughened titanium surface with a poly(ethylene glycol) to covalently bond the poly(ethylene glycol) directly to a titanium atom of the roughened titanium surface by an inorganic ether bond.

US Pat. No. 10,335,510

METHOD AND DEVICE FOR FEMALE URINARY INCONTINENCE

ParaPatch, Inc., Campbel...

1. A patch for treating female urinary incontinence, the patch sized and configured to fit directly on and cover a clitoris without covering a urethra, the patch configured when applied to stimulate the clitoris to inhibit discharge from a bladder.

US Pat. No. 10,335,508

SYSTEMS AND METHODS FOR SANITIZING SURFACES

LivOnyx Inc., Allston, M...

1. A method for killing or inactivating pathogens on a surface, comprising:spraying an aerosolized layer of an active agent onto the surface, the layer being a thin and substantially uniform coating,
wherein the spraying occurs over a first time period and the aerosolized layer dries over a second time period while being effective to kill or inactivate the pathogen on the surface, and wherein a duration of the first and second time periods together is less than 5 seconds.

US Pat. No. 10,335,507

STERILIZATION SYSTEM FOR A BLOW/FILL/SEAL MACHINE

Weiler Engineering, Inc.,...

1. A sterilization system for a blow/fill/seal machine having a fill assembly, and comprisinga shroud enclosing the fill assembly and defining a plenum, a sterilizing gas inlet and a sterilizing gas outlet;
an external conduit defining at least one sterilizing gas flow passageway between said sterilizing gas inlet and said sterilizing gas outlet;
a blower in the external conduit adjacent to said sterilizing gas inlet for introducing into and circulating the sterilizing gas through the shroud;
a sterilizing gas source connected to the external conduit upstream from the blower in confined flow communication with the blower; and
a humidifier and a humidified conduit in confined flow communication with the external conduit between the blower and a HEPA filter.

US Pat. No. 10,335,506

MOBILE ULTRAVIOLET LAMP APPARATUSES HAVING A REFLECTOR SYSTEM THAT REDIRECTS LIGHT TO A HIGH TOUCH AREA OF A ROOM

Xenex Disinfection Servic...

1. An apparatus, comprising:a germicidal lamp configured to emit ultraviolet light, wherein the germicidal lamp is arranged lengthwise substantially parallel to a horizontal plane of the apparatus;
a mobile carriage supporting the germicidal lamp, wherein the mobile carriage comprises:
one or more compartments underneath said arranged germicidal lamp, wherein the one or more compartments hold operational components for the apparatus;
a casing enclosing the one or more compartments, wherein the apparatus is configured such that the germicidal lamp is not moveable beyond vertical planes aligned with the casing when the germicidal lamp is supported by the mobile carriage; and
wheels along a bottom of the mobile carriage to affect portability of the apparatus; and
a reflector system arranged in the apparatus such that ultraviolet light emitted from the germicidal lamp is projected to a region exterior to the apparatus between approximately 2 feet and approximately 4 feet from a floor of a room in which the apparatus is arranged, wherein the apparatus is configured such that a reflector of the reflector system is moveable relative to the mobile carriage.

US Pat. No. 10,335,505

STERILIZATION DEVICE FOR INCISION AND WOUND SITES UTILIZING LOW INTENSITY UV-C RADIATION AND OZONE

Hepco Holdings, LLC, Sem...

13. A system for radiating skin comprising:an enclosure;
one or more ultraviolet emitters housed in the enclosure and covered by a filter, the filter passing ultraviolet light from the one or more ultraviolet emitters, the one or more ultraviolet emitters configured to emit ultraviolet light from the housing, through the filters, and onto a surface of skin where ozone is produced by ultra violet light emitted from the one or more ultraviolet emitters;
means for detecting contact with the surface of the skin, the means for detecting contact prevents the one or more ultraviolet emitters from emitting the ultraviolet light until contact is made with the surface of the skin; and
a timer configured to connect a source of power to the one or more ultraviolet emitters for a period of time responsive to the means for detecting the surface indicating contact with the surface of the skin;
wherein the one or more skin contact detectors comprises an ultrasonic distance measurement device that detects proximity to the skin.

US Pat. No. 10,335,504

HETEROCYCLIC MOLECULES FOR BIOMEDICAL IMAGING AND THERAPEUTIC APPLICATIONS

Washington University, S...

1. A compound or a pharmaceutically acceptable salt thereof selected from the group consisting ofor a pharmaceutically acceptable salt thereof.

US Pat. No. 10,335,503

COMPOUND THAT SPECIFICALLY BINDS TO AMPA RECEPTOR

Public University Corpora...

1. A compound of Formula (I), or a pharmaceutically acceptable salt thereof or solvate thereof:
wherein:
each of A and Z independently is CO, SO, or SO2;
each of X and Y independently is S or O;
each of R1, R3, and R4 independently is hydrogen, alkyl, alkenyl, alkynyl, or halo;
R2 is alkyl, alkenyl, or alkynyl;
each R5 independently is alkyl, alkenyl, alkynyl, or halo; and
n is an integer of 0 to 4.

US Pat. No. 10,335,497

PYRROLOBENZODIAZEPINES AND CONJUGATES THEREOF

MEDIMMUNE LIMITED, Cambr...

1. A method of synthesising compound B:
from:

via the intermediate:
which comprises the steps of:(i) removing the Alloc
protecting groups; and(ii) reacting the product of (i) with Mal-(PEG)8-acid.

US Pat. No. 10,335,496

ROR1 ANTIBODY IMMUNOCONJUGATES

VelosBio Inc., San Diego...

1. An immunoconjugate comprising an antibody conjugated to a cytotoxic drug moiety, wherein the VH and VL of the antibody comprise the amino acid sequences of SEQ ID NOs: 5 and 6, respectively, and the immunoconjugate isADC-A, having the structure












wherein Ab in the structure is the antibody.

US Pat. No. 10,335,495

BIOMOLECULE CONJUGATES

CELGENE CORPORATION, Sum...

1. A compound of Formula I
wherein
A is dibenzocyclooctynyl, cyclooct-4-ynoxyl, or (1R,8S,9S)-bicyclo[6.1.0]non-4-yn-9-ylmethyloxy;
D is a maytansinoid;
m is 1;
E is

wherein:
J is an amino acid or peptide;
h is an integer from 0 to 30;
d, e, g, j, and k are each independently an integer from 1 to 30;
each R4 is independently H, alkyl, —N(R3)2, —SR3, and C1-C8 alkoxy, aryl;
each of R3 or R3? is H, C1-C8 alkyl; and
“d is 5” and “R3? is H” are not satisfied simultaneously.

US Pat. No. 10,335,491

CATALYTIC DELIVERY NANOSUBSTRATES (CDNS) FOR HIGHLY EFFICIENT DELIVERY OF BIOMOLECULES

The Regents of the Univer...

1. A molecular delivery system, comprising:a substrate having
a nanostructured surface region which comprises a plurality of nanostructures and, covalently attached to the nanostructured surface region, multiple copies of a first member of a binding pair; and
at least one vector nanoparticle which comprises
encapsulated therein, a molecule of interest, and,
on its surface, multiple copies of a second member of the binding pair,
wherein the plurality of nanostructures are nanofibers or nanowires made of silicon, titanium, aluminum, steel, or an organic oxide, or are organic polymers comprising at least one of polymethacrlate, polysaccharide or polylactide,
wherein the plurality of nanostructures comprise a length and diameter such that the length is greater than the diameter,
wherein the plurality of nanostructures are attached at a first end to the substrate, and
wherein the first member of the binding pair is covalently attached to an outer surface region of the plurality of nanostructures such that the at least one vector nanoparticle is attached to the outer surface region of the plurality of nanostructures when the second member of the binding pair and the first member of the binding pair are engaged, and
wherein each vector nanoparticle further comprises:
a plurality of structural components that are suitable to at least provide some mechanical structure to said vector nanoparticle;
a plurality of binding components, each having a plurality of binding regions adapted to bind to said plurality of structural components; and
a plurality of terminating components, each of which is adapted to bind to a binding region of one of said plurality of binding components,
wherein said plurality of structural components and said plurality of binding components self-assemble when brought into contact to form said vector nanoparticle,
wherein said plurality of terminating components act to occupy binding regions of said plurality of binding components to terminate further binding when said plurality of terminating components are present in a sufficient quantity relative to said plurality of binding regions of said plurality of binding components,
wherein the plurality of binding regions comprise ?-cyclodextrin,
wherein each of said plurality of structural components comprises at least one binding element adapted to bind to the binding regions to form a first inclusion complex,
wherein the binding element comprises adamantine,
wherein the first inclusion complex is adamantine-?-cyclodextrin,
wherein each of the plurality of terminating components comprise a single terminating binding element that binds to remaining binding regions of one of said plurality of binding components by forming a second inclusion complex,
wherein said terminating binding element comprises adamantine, and
wherein said second inclusion complex is adamantine-?-cyclodextrin.

US Pat. No. 10,335,490

FLUORINATED POLYMERIZABLE HYDROGELS FOR WOUND DRESSINGS AND METHODS OF MAKING SAME

The University of Akron, ...

1. A hydrogel comprising:crosslinked polymers, the polymers having polysaccharide backbone chains, wherein the polysaccharide backbone chains have a pendant fluorine group attached thereto; and
wherein the polysaccharide backbone chains include one or more saccharide units that include an alkene group selected from the group consisting of:

US Pat. No. 10,335,489

INJECTABLE SOLUTION AT PH 7 COMPRISING AT LEAST ONE BASAL INSULIN THE PI OF WHICH IS BETWEEN 5.8 AND 8.5 AND A SUBSTITUTED CO-POLYAMINO ACID

ADOCIA, Lyons (FR)

1. A composition in the form of an injectable aqueous solution, the pH of which is between 6.0 and 8.0, comprising at least:a) a basal insulin, the isoelectric point pI of which is between 5.8 and 8.5;
b) a prandial insulin,
c) a co-polyamino acid bearing carboxylate charges and substituted with hydrophobic groups, chosen from the co-polyamino acids of formula I:

 in which:
A independently represents either a —CH2— group (aspartic unit) or a —CH2—CH2— group (glutamic unit),
R1 is a radical chosen from the group consisting of an H, a linear C2 to C10 acyl group, a branched C3 to C10 acyl group, a benzyl, a terminal “amino acid” unit and a pyroglutamate,
R2 is an —NR?R? radical, R? and R?, which may be identical or different, being chosen from the group consisting of H, linear or branched or cyclic C2 to C30 alkyls and benzyl, and said R? and R? alkyls being alkyls which can together form one or more saturated, unsaturated and/or aromatic rings which are carbon-based and/or which can comprise heteroatoms, chosen from the group consisting of O, N and S,
R?3 is a radical chosen from the group consisting of the radicals of formulae —OR3, II or II?:

 in which * indicates the site of attachment to the co-polyamino acid
R3 and R?3, which may be identical or different, represent an H or a cationic entity chosen from the group comprising metal cations,
—R is a hydrophobic radical chosen from the group consisting of a saturated or unsaturated, linear or branched C8 to C30 radical which can comprise heteroatoms or a C8 to C30 radical which can form rings which are carbon-based or which can comprise heteroatoms, which are saturated, unsaturated and/or aromatic, said rings possibly being ortho-condensed or peri-condensed, or a radical of formula III or III? as defined below:

 in which * indicates the site of attachment to the co-polyamino acid, and
R4 and R?4, which may be identical or different, represent an H, a cationic entity chosen from the group comprising metal cations, an R?4 radical or an R??4 radical, and at least one of R4 and R?4 is equal to R?4,
R?4 represents a saturated or unsaturated, linear or branched C8 to C30 radical which can comprise heteroatoms or a C8 to C30 radical which can form rings which are carbon-based or which can comprise heteroatoms, which are saturated, unsaturated and/or aromatic, said rings possibly being ortho-condensed or peri-condensed,
R??4 represents a saturated or unsaturated, linear or branched C1 to C7 radical which can comprise heteroatoms or a C1 to C7 radical which can form rings which are carbon-based or which can comprise heteroatoms, which are saturated, unsaturated and/or aromatic, said rings possibly being ortho-condensed or peri-condensed, and
B independently represents either a —CH2— group (aspartic unit) or a —CH2—CH2— group (glutamic unit),
R5 is a radical chosen from the group consisting of an H, a linear or branched C1 to C4 alkyl or a benzyl group,
n/(n+m) is defined as the molar degree of grafting with hydrophobic radical of the monomeric units and is between 1 and 50 mol %,
n+m represents the degree of polymerization of the co-polyamino acid, i.e. the average number of monomeric units per chain of co-polyamino acid, and 5 ?n+m?1000.

US Pat. No. 10,335,487

METHODS FOR TARGETING OR STIMULATING CELLS OR ORGANISMS USING NANOPARTICLES AND EXTERNAL FIELD

Ping Liang, Newport Coas...

1. A method for targeting cells that are less negatively charged than surrounding cells comprisinginjecting a solution of nano-particles at an area, wherein the nano-particles are Magneto-Electric Nano-Particles (MENPs),
increasing negative charges of the nano-particles so as to produce an electric gradient field, which is accomplished by applying for a period of time an external field on the MENPs; and
the electric gradient field pushing or driving the nano-particles from the area toward the less negatively charged cells;
wherein the method further comprises (1) placing, injecting or implanting one or more permanent magnets or electro-magnets in a cancer site, wherein the magnets) serves to attract MENPs to and increase accumulation of MENPs in the cancer site, as well as to increase the negative charges of the MENPs to steer the MENPs towards cancer cells; (2) injecting or implanting wires, liquid capsules, injectable macro-particles, made of permanent magnetic material into a solid tumor site that is inside a body or an organ, wherein the magnetic field produced by these injected or implanted magnetic sources serve to localize and accumulate the MENPs at cancer sites, and at the same time to enhance the electric field gradient to push MENPs to cancer cells; or (3) using an apparatus formed into a shape and dimension to fit a target area or volume that is made of or using permanent magnetic material and with one or more electromagnets embedded in the apparatus to generate a constant magnetic field and a changing magnetic field simultaneously.

US Pat. No. 10,335,477

COMPOSITIONS AND METHODS FOR DIAGNOSING, PREVENTING AND TREATING SALMONELLA TYPHI AND SALMONELLA PARATYPHI INFECTION

YALE UNIVERSITY, New Hav...

1. An immunological composition comprisinga.) a mutant Pertussin-like toxin A (PltA) polypeptide comprising the mutation E133A within SEQ ID NO: 8,
b.) a mutant Cytolethal distending toxin B (CdtB) polypeptide comprising the mutation H160Q within SEQ ID NO: 7 and
c.) a Pertussin-like toxin B (PltB) polypeptide.

US Pat. No. 10,335,452

METHOD OF TREATING PATIENTS WITH HEPATORENAL SYNDROME TYPE 1

Mallinckrodt Hospital Pro...

1. A method of treating type 1 hepatorenal syndrome (HRS-1), the method comprising:identifying a plurality of patients as having HRS-1;
determining that a first patient of the plurality exhibits at least two of the following three criteria for Systemic Inflammatory Response Syndrome (SIRS):
(i) a white blood cell count (WBC) less than 4,000 cells/mm3 or greater than 12,000 cells/mm3,
(ii) a heart rate of greater than 90 beats per minute (BPM), and
(iii) either a partial pressure of carbon dioxide in the blood (PaCO2)<32 mmHg or a blood bicarbonate (HCO3) level<23 mmol/L;
determining that the first patient does not have overt sepsis, septic shock, or uncontrolled infection;
determining that, because the first patient exhibits at least two of the three criteria and does not have overt sepsis, septic shock, or uncontrolled infection, the HRS-1 of the first patient is likely to respond to treatment with terlipressin;
administering to the first patient an amount of terlipressin effective to treat HRS-1 in the first patient;
determining that a second patient of the plurality exhibits only one or none of the three criteria or has overt sepsis, septic shock, or uncontrolled infection;
determining that, because the second patient does not exhibit at least two of the three criteria or has overt sepsis, septic shock, or uncontrolled infection, the HRS-1 of the second patient is unlikely to respond to treatment with terlipressin;
excluding the second patient from treatment with terlipressin determining that a third patient of the plurality has overt sepsis, septic shock, or uncontrolled infection; and
excluding the third patient from treatment with terlipressin.

US Pat. No. 10,335,445

COMPOSITIONS AND METHODS OF ANTIALLERGIC PHORBOL ESTER AND PHORBOL DERIVATIVES AS THE MAIN ACTIVE INGREDIENTS FROM THE SEEDS OF AQUILARIA MALACCENSIS

WE-WIN APPLIED BIO-TECH C...

1. A method for preparing compositions from Aquilaria malaccensis seeds, the method including the following steps:(a) extracting Aquilaria malaccensis seeds that are air dried and powdered with 90% ethanol at room temperature in triplicate and concentrating the extract under a reduced pressure to provide an ethanolic extract;
(b) partitioning the ethanolic extract by suspending the ethanolic extract in water, followed by partitioning carried out with equivalent ethyl acetate in triplicate, so as to separate an organic ethyl acetate layer;
(c) subjecting the ethyl acetate layer to partitioning with n-hexane and 90% aqueous methanol (MeOH) to obtain a hexane layer and a MeOH layer;
(d) subjecting the MeOH layer to column chromatography over silica gel under gradient elution of n-hexane/CH2Cl2/MeOH of 6:3:1, 6:4:1, 6:6:1, 6:8:1, 6:10:1 and 5:10:2 to yield six respective fractions of AM1, 6:3:1; AM2, 6:4:1; AM3, 6:6:1; AM4, 6:8:1; AM5, 6:10:1; and AM6, 6:10:2;
(e) fractioning fraction AM4 over a dextran bead sizing column with a ratio of CH2Cl2/MeOH being 1:1 to obtain eight sub-fractions, which are respectively AM4-1 to AM4-8;
(f) subjecting fraction AM4-3 to column chromatography over silica under gradient elution of EtOAc/n-hexane from 1:10 to, 4:1 to obtain fifteen AM4-3 originating subfractions, which are respectively AM4-3-1 to AM4-3-15; and
(g) separating fraction AM4-4 with column chromatography on silica gel under gradient elution of EtOAc/n-hexane from 1:15 to 4:1 to obtain twelve AM4-4 originating subfractions, which are respectively AM4-4-1 to AM4-4-12,
wherein the fifteen AM4-3 originating subfractions and the twelve AM4-4 originating subfractions are further separated on column chromatography over silica gel to provide phorbol esters of the following formulas:
Formula I: 12-O-(2Z,4E,6E)-tetradeca-2,4,6-trienoylphorbol-13-acetate having a molecular formula C36H50O8 of structural formula:

Formula II: 12-deoxy-13-O-acetoylphorbol-20-octadec-9-enoate having a molecular formula C40H62O7 of structural formula:

Formula III: 12-O-(2E,4E)-6-oxohexa-2,4-dienoylphorbol-13-acetate having a molecular formula C28H34O9 of structural formula:
andFormula IV: 12-O-(2E,4E)-6,7-dihydroxytetradeca-2,4-dienoylphorbol-13-acetate having a molecular formula C36H52O10 of structural formula:
wherein Formula I derives from the subfraction AM4-4-9, Formula II derives from the subfractions AM4-3-6 and AM4-4-3, and Formulas III and IV derive from the subfraction AM4-3-13.

US Pat. No. 10,335,432

MICROPOROUS ZIRCONIUM SILICATE FOR THE TREATMENT OF HYPERKALEMIA

ZS PHARMA, INC., Coppell...

1. A method of treating hyperkalemia in a subject in need thereof comprising administering between 3 and 9 g per day of particles with a uniform microporous structure, a pore diameter of about 3 angstroms, and a median particle size greater than 3 microns, the particles being capable of binding potassium with a potassium exchange capacity (KEC) of at least 1.7 mEq/g, wherein less than 7% of the administered particles are under 3 microns.

US Pat. No. 10,335,431

METHOD FOR PRODUCING POLYGUANIDINES

Sealife Pharma GmbH, Tul...

1. A method for preparing polycondensation products from guanidine, aminoguanidine or diaminoguanidine G with one or more benzyl or allyl derivatives BA according to the following reaction scheme:
wherein
each X independently represents a leaving group;
each R1 independently represents either an aromatic ring system with at least one aromatic ring, optionally containing one or more hetero atoms selected from the group consisting of O, N and S and optionally being substituted with one or two vinyl groups to which the —CH2—X group(s) is/are bound, or represents ethylene;
Gua represents a guanidindiyl, aminoguanidindiyl or diaminoguanidindiyl residue;
Y represents H-Gua, and
Z represents H; or
Y and Z together represent a chemical bond to obtain a cyclic structure; and
n is ?2;
wherein at least one benzyl or allyl derivative BA is subjected to a polycondensation reaction with excessive guanidine, aminoguanidine or diaminoguanidine G upon elimination of HX in order to provide a polyguanidine corresponding to the following formula (I), (II) or (III):

or having a cyclic structure resulting from cyclization upon elimination of a corresponding guanidine, or a salt of said polyguanidine.

US Pat. No. 10,335,426

N-ACETYL MANNOSAMMINE AS A THERAPEUTIC AGENT

THE UNITED STATES OF AMER...

1. A method of treating a condition or disease in a mammal in need thereof comprising selecting a subject with the condition or disease, and administering to the subject an effective amount of N-acetyl mannosamine or a derivative thereof, to the mammal, wherein the derivative consists of Formula I.wherein R1, R3, R4, or R5 is hydrogen, lower alkanoyl, carboxylate or lower alkyl; R2 is lower alkyl, lower alkanoylalkyl, lower alkyl alkanoyloxy; and the condition or disease is diabetic nephropathy.

US Pat. No. 10,335,425

COMPOSITIONS AND METHODS OF TREATING OF BACTERIAL INFECTIONS WITH ?-LACTAMASE INHIBITORS

CASE WESTERN RESERVE UNIV...

1. A pharmaceutical composition comprising a therapeutically effective amounts of at least one ?-lactam antibiotic and at least one triazolylmethyl boronic acid, wherein the triazolylmethyl boronic acid is selected from the group consisting of:
wherein R1?CH2NHC(?O)-phenyl or benzyl, CH2NHS(?O)2-phenyl or alkyl substituted phenyl, —COOH, ester, aryl, heteroaryl, or —CH2Oaryl;
R3=benzyl, alkyl, H or —CH2-benzoic acid;
R4±S(?O)2-phenyl or alkyl substituted phenyl, C(?O)-phenyl or benzyl, C(?O)NH-phenyl;
R5=—COOH or H; and pharmaceutically acceptable salts thereof.

US Pat. No. 10,335,423

INHIBITION OF HIV INFECTION THROUGH CHEMOPROPHYLAXIS

THE UNITED STATES OF AMER...

1. A process of protecting a primate host from a self-replicating infection by an immunodeficiency retrovirus comprising:(a) selecting a primate host not infected with the immunodeficiency retrovirus, and
(b) administering directly to the primate host a combination comprising:
i. a pharmaceutically effective amount of emtricitabine; and
ii. a pharmaceutically effective amount of tenofovir or a tenofovir prodrug,
wherein the combination is administered orally prior to the exposure of the primate host to the immunodeficiency retrovirus,
thereby protecting the primate host from infection with the immunodeficiency retrovirus.

US Pat. No. 10,335,420

NANOPARTICLE-BASED TUMOR-TARGETED DRUG DELIVERY

The Scripps Research Inst...

1. An aqueous tumor-targeting liposome nanoparticle composition comprising an aqueous dispersion of liposome nanoparticles; the liposome nanoparticles comprising a legumain-targeting lipid component and a polyethylene glycol-conjugated lipid component; the legumain-targeting lipid component comprising a hydrophobic lipid portion covalently attached to a legumain-binding moiety, wherein the legumain-targeting lipid component comprises a compound of the Formula:

US Pat. No. 10,335,419

SLOW RELEASE OXYSTEROLS AND METHODS OF USE

Warsaw Orthopedic, Inc, ...

1. A method of treating a bone defect site, the method comprising: implanting an implant at the bone defect site, the implant comprising a slow release composition to promote bone growth, the slow release composition comprising: an oxysterol comprising (3S,5S,6S,8R,9S,10R,13S,14S,17S)17-((S)-2-hydroxyoctan-2-yl)-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthrene-3,6-diol (Oxy133) monohydrate encapsulated in a biodegradable polymer to control the release of the oxysterol, wherein the biodegradable polymer is in the form of microspheres disposed within a biodegradable matrix, the oxysterol is in an amount of about 5 wt % of the biodegradable matrix, the biodegradable matrix further comprising mineral particles in an amount of about 80 wt % of the biodegradable matrix, and the mineral particles comprise tricalcium phosphate and hydroxyapatite in a ratio of about 85:15, wherein the composition comprises carboxymethyl cellulose (CMC) in an amount of about 4 wt % of the composition, and the biodegradable matrix comprises collagen in an amount of about 12 wt % of the biodegradable matrix, wherein the collagen comprises insoluble and soluble collagen in a weight ratio of about 75:25 to about 65:35.

US Pat. No. 10,335,418

METHODS AND COMPOSITIONS FOR TREATING METABOLIC SYNDROME

Topokine Therapeutics, In...

1. A method for reducing body fat in an individual, the method comprising administering systemically to the skin of the individual a pharmaceutical composition comprising a compound of formula:
or a pharmaceutically acceptable salt thereof,
wherein the individual suffers from an excess of body fat.

US Pat. No. 10,335,417

THIAZIDEAMIDE DERIVATIVE AND USE THEREOF

Institute of Pharmacology...

1. A compound, or a pharmaceutically acceptable salt or solvate thereof, wherein the compound is selected from:

US Pat. No. 10,335,415

(ALPHA-SUBSTITUTED ARALKYLAMINO AND HETEROARYLALKYLAMINO) PYRIMIDINYL AND 1,3,5-TRIAZINYL BENZIMIDAZOLES, PHARMACEUTICAL COMPOSITIONS THEREOF, AND THEIR USE IN TREATING PROLIFERATIVE DISEASES

MEI PHARMA, INC., San Di...

1. A compound of Formula II:
or an enantiomer, a mixture of enantiomers, a mixture of two or more diastereomers, or an isotopic variant thereof; or a pharmaceutically acceptable salt, solvate or hydrate thereof; wherein:X, Y, and Z are each independently N;R1 and R2 are each independently (a) hydrogen, cyano, halo, or nitro;(b) C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 cycloalkyl, C6-14 aryl, C7-15 aralkyl, heteroaryl, or heterocyclyl; or (c) —C(O)R1a, —C(O)OR1a, —C(O)NR1bR1c, —C(NR1a)NR1bR1c, —OR1a, —OC(O)R1a, —OC(O)OR1a, —OC(O)NR1bR1c, —OC(?NR1a)NR1bR1c, —OS(O)R1a, —OS(O)2R1a, —OS(O)NR1bR1c, —OS(O)2NR1bR1c, —NR1bR1c, —NR1aC(O)R1d, —NR1aC(O)OR1d, —NR1aC(O)NR1bR1c, —NR1aC(?NR1d)NR1bR1c, —NR1aS(O)R1d, —NR1aS(O)2R1d, —NR1aS(O)NR1bR1c, —NR1aS(O)2R1bR1c, —SR1a, —S(O)R1a, —S(O)2R1a, —S(O)NR1bR1c, or —S(O)2NR1bR1c; wherein each R1a, R1b, R1c, and R1d is independently (i) hydrogen;
(ii) C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 cycloalkyl, C6-14 aryl, C7-15 aralkyl, heteroaryl, or heterocyclyl; or (iii) R1b and R1c together with the N atom to which they are attached form heterocyclyl;R3 and R4 are each independently hydrogen or C1-6 alkyl; or R3 and R4 are linked together to form a bond, C1-6 alkylene, C1-6 heteroalkylene, C2-6 alkenylene, orC2-6 heteroalkenylene;R5a is hydrogen or C1-6 alkyl;R5b is C1-6 alkyl or —C(O)OR1a;R5c is —(CR5fR5g)n—(C6-14 aryl);R5f and R5g are each independently (a) hydrogen or halo; (b) C1-6 alkyl,C2-6 alkenyl, C2-6 alkynyl, C3-10 cycloalkyl, C6-14 aryl, C7-15 aralkyl, heteroaryl, or heterocyclyl; or (c) —C(O)R1a, —C(O)OR1a, —C(O)NR1bR1c, —C(NR1a)NR1bR1c, —OR1a, —OC(O)R1a, —OC(O)OR1a, —OC(O)NR1bR1c, —OC(?NR1a)NR1bR1c, —OS(O)R1a, —OS(O)2R1a, —OS(O)NR1bR1c, —OS(O)2NR1bR1c, —NR1bR1c, —NR1aC(O)R1d, —NR1aC(O)OR1d, —NR1aC(O)NR1bR1c, —NR1aC(?NR1d)NR1bR1c, —NR1aS(O)R1d, —NR1aS(O)2R1d, —NR1aS(O)NR1bR1c, —NR1aS(O)2NR1bR1c, —SR1a, —S(O)R1a, —S(O)2R1a, —S(O)NR1bR1c; or —S(O)2NR1bR1c; or (d) when one occurrence of R5f and one occurrence of R5g are attached to the same carbon atom, the R5f and R5g together with the carbon atom to which they are attached form a C3-10 cycloalkyl or heterocyclyl;R6 is C1-6 alkyl; andn is 0 or 1;wherein each alkyl, alkylene, heteroalkylene, alkenyl, alkenylene, heteroalkenylene, alkynyl, cycloalkyl, aryl, aralkyl, heteroaryl, and heterocyclyl in R1, R2, R3, R4, R6, R1a, R1b, R1c, R1d, R5a, R5b, R5c, R5f, and R5g is optionally substituted with one, two, three, four, or five substituents Q, wherein each substituent Q is independently selected from (a) oxo, cyano, halo, and nitro; (b) C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 cycloalkyl, C6-14 aryl, C7-15 aralkyl, heteroaryl, and heterocyclyl, each of which is further optionally substituted with one, two, three, or four substituents Qa; and (c) —C(O)Ra, —C(O)ORa,—C(O)NRbRc, —C(NRa)NRbRc, —ORa, —OC(O)Ra, —OC(O)ORa, —OC(O)NRbRc, —OC(?NRbRc, —OS(O)Ra, —OS(O)2Ra, —OS(O)NRbRc, —OS(O)2NRbRc, —NRbRc, —NRaC(O)Rd, —NRaC(O)ORd, —NRaC(O)NRbRc, —NRaC(?NRd)NRbRc, —NRaS(O)Rd, —NRaS(O)2Rd, —NRaS(O)NRbRc, —NRaS(O)2NRbRc, —SRa, —S(O)Ra, —S(O)2Ra, —S(O)NRbRc, and —S(O)2NRbRc, wherein each Ra, Rb, Rc, and Rd is independently (i) hydrogen;
(ii) C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 cycloalkyl, C6-14 aryl, C7-15 aralkyl, heteroaryl, or heterocyclyl, each of which is further optionally substituted with one, two, three, or four substituents Qa; or (iii) Rb and Rc together with the N atom to which they are attached form heterocyclyl, which is further optionally substituted with one, two, three, or four substituents Qa; andwherein each Qa is independently selected from the group consisting of (a) oxo, cyano, halo, and nitro; (b) C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 cycloalkyl, C6-14 aryl, C7-15 aralkyl, heteroaryl, and heterocyclyl; and (c) —C(O)Re, —C(O)ORe, —C(O)NRfRg, —C(NRe)NRfRg, —ORe, —OC(O)Re, —OC(O)ORe, —OC(O)NRfRg, —OC(?NRe)NRfRg, —OS(O)Re, —OS(O)2Re, —OS(O)NRfRg, —OS(O)2NRfRg, —NRfRg, —NReC(O)Rh, —NReC(O)ORh, —NReC(O)NRfRg, —NReC(?NRh)NRfRg, —NReS(O)Rh, —NReS(O)2Rh, —NReS(O)NRfRg, —NReS(O)2NRfRg, —SRe, —S(O)Re, —S(O)2Re, —S(O)NRfRg, and —S(O)2NRfRg; wherein each Re, Rf, Rg, and Rh is independently (i) hydrogen; (ii) C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 cycloalkyl, C6-14 aryl, C7-15 aralkyl, heteroaryl, or heterocyclyl; or (iii) Rf and Rg together with the N atom to which they are attached form heterocyclyl.

US Pat. No. 10,335,413

SUBSTITUTED XANTHINE DERIVATIVES

Concert Pharmaceuticals, ...

1. A method of treating a disease or condition in a patient in need thereof, comprising administering to the patient an effective amount of a compound represented by the following structural formula:
or a pharmaceutically acceptable salt thereof, wherein R1 is selected from —CH3 and —CD3;
R2 is selected from —CH3 and —CD3; Y1 is deuterium or hydrogen, wherein the isotopic enrichment factor for each designated deuterium atom is at least 5000, wherein the disease is selected from insulin dependent diabetes, non-insulin dependent diabetes, metabolic syndrome, obesity, insulin resistance, dyslipidemia, pathological glucose tolerance, hypertension, hyperlipidemia, hyperuricemia, gout, and hypercoagulability.

US Pat. No. 10,335,410

HETEROARYL COMPOUNDS USEFUL AS INHIBITORS OF SUMO ACTIVATING ENZYME

Millennium Pharmaceutical...

1. A method of treating lung cancer, ovarian cancer, colon cancer, breast cancer, or lymphoma in a subject, comprising administering to a subject having lung cancer, ovarian cancer, colon cancer, breast cancer, or lymphoma a therapeutically effective amount of a chemical entity which is a compound or pharmaceutically acceptable salt of formula (I):
wherein:
stereochemical configurations depicted at asterisked positions indicate absolute stereochemistry;
Y is —O—, —CH2—, or —N(H)—;
Ra is hydrogen, fluoro, —NH2, or hydroxyl;
Ra? is hydrogen or fluoro, provided that when Ra is —NH2 or hydroxyl, Ra? is hydrogen;
Rb is hydrogen or, together with the oxygen to which it is attached, forms a prodrug;
Rc is hydrogen or C1-4 alkyl;
Rd is hydrogen, halogen, —CF3, or C1-4 alkyl;
X1 is N;
X2 is S or O;
X3 is C(Rx3) or N;
Rx3 is hydrogen, methyl, or halogen;
Z1 is hydrogen, halogen, cyano, Rz3, —S—Rz3, —S(O)—Rz3, or —S(O)2—Rz3;
Rz3 is an optionally substituted phenyl, an optionally substituted 5- to 7-membered cycloaliphatic, an optionally substituted 5- to 7-membered heterocyclyl, or an optionally substituted C1-4 aliphatic;
wherein Z1 is not hydrogen, halogen, methyl, or cyano if Z2 is hydrogen or methyl; and
(a) Z2 is a ring system having an optionally substituted 5- to 7-membered heterocyclyl with 1-2 heteroatoms or an optionally substituted 5- to 7-membered cycloaliphatic fused to
(i) an optionally substituted 5-membered heteroaryl or an optionally substituted 6-membered aryl or heteroaryl to form a bicyclic group; or
(ii) an optionally substituted 9-membered heteroaryl or an optionally substituted 10-membered aryl or heteroaryl to form a tricyclic group;
or
(b) Z2 is L-Re wherein L is L1-, —V1-L2-, or L1-V1-L2-;
L1 is a C1-3 alkylene chain wherein 1 or 2 saturated carbon atoms are optionally substituted by (Rf)(Rf?) and in which there are optionally one or two degrees of unsaturation;
each Rf is independently hydrogen; hydroxyl; —N(Rh)(Rh?); C1-4 aliphatic optionally substituted with hydroxyl, —OCH3, or cyclopropyl; —O—C1-4 aliphatic optionally substituted with hydroxyl, —OCH3, or cyclopropyl; or, together with Rf? and the carbon atom to which they are attached, form C?CH2, or a 3- to 6-membered carbocycle or 4- to 6-membered heterocycle comprising a heteroatom chosen from N (which may be protonated or C1-4 alkylated), O, or S, the heteroatom optionally located immediately adjacent to the quaternary carbon of the heterocycle;
each Rf? is independently hydrogen; C1-4 aliphatic optionally substituted with hydroxyl, —OCH3, or cyclopropyl; —O—C1-4 aliphatic optionally substituted with hydroxyl, —OCH3, or cyclopropyl; or, together with Rf and the carbon atom to which they are attached, form C?CH2, or a 3- to 6-membered carbocycle or 4- to 6-membered heterocycle comprising a heteroatom chosen from N (which may be protonated or C1-4 alkylated), O, or S, the heteroatom optionally located immediately adjacent to the quaternary carbon of the heterocycle; wherein if Rf is hydroxyl, Rf? is not —O—C1-4 aliphatic optionally substituted with hydroxyl, —OCH3, or cyclopropyl;
Rh and Rh? are each independently hydrogen or C1-4 alkyl;
V1 is —S—, —O—, —S(O)—, —S(O)2—, —C(O)— or —N(Rg)—;
L2 is a C0-2 alkylene chain wherein one saturated carbon atom is optionally substituted by (Rf)(Rf?);
Rg is hydrogen or C1-4 alkyl; and
either (i) Re is hydrogen, hydroxyl, halogen, —CF3, or an optionally substituted C1-4 aliphatic,
with the proviso that Re is not hydrogen if Rf and Rf? are present and form a ring; or
(ii) Re is a ring chosen from optionally substituted 6-membered aryl, optionally substituted 5-to 6-membered heteroaryl, optionally substituted 3- to 7-membered cycloaliphatic, or optionally substituted 4- to 7-membered heterocyclyl, which is optionally fused to a second optionally substituted 6-membered aryl, optionally substituted 5-to 6-membered heteroaryl, optionally substituted 3- to 7-membered cycloaliphatic, or optionally substituted 4- to 7-membered heterocyclyl;
or
(c) Z2 is hydrogen.

US Pat. No. 10,335,403

NIACIN FORMULATION

ZEENAR ENTERPRISE PTY LTD...

1. A method for prolonging the release of niacin in a subject, comprising:administering to the oral mucosa of a subject in need thereof a composition comprising an amphiphilic compound capable of self-assembling into a liquid crystalline phase upon contact with a hydrophilic solvent and a therapeutically effective amount of a niacin compound, and
prolonging release of the niacin compound in the subject for up to 12 hours.

US Pat. No. 10,335,401

NON-AROMATIC HETEROCYCLIC DERIVATIVE HAVING MGAT2 INHIBITORY ACTIVITY

1. A compound represented by Formula (I):whereinX is C(?O), C(?S), or SO2;
Z is C(?O), C(?S), C(?N—RN), or SO2;
L is a single bond, —O—, —S—, or —NRN—;
R is R6 or a group represented by the following formula:

A is aromatic carbocycle, non-aromatic carbocycle, aromatic heterocycle, or non-aromatic heterocycle;
B is aromatic carbocycle, non-aromatic carbocycle, aromatic heterocycle, or non-aromatic heterocycle;
R2 is hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkylcarbonyl, substituted or unsubstituted alkyloxycarbonyl, substituted or unsubstituted alkylsulfonyl, substituted or unsubstituted aromatic carbocyclyl, substituted or unsubstituted non-aromatic carbocyclyl, substituted or unsubstituted aromatic heterocyclyl, substituted or unsubstituted non-aromatic heterocyclyl, substituted or unsubstituted aromatic carbocyclylcarbonyl, substituted or unsubstituted non-aromatic carbocyclylcarbonyl, substituted or unsubstituted aromatic heterocyclylcarbonyl, substituted or unsubstituted non-aromatic heterocyclylcarbonyl, substituted or unsubstituted aromatic carbocyclyloxycarbonyl, substituted or unsubstituted non-aromatic carbocyclyloxycarbonyl, substituted or unsubstituted aromatic heterocyclyloxycarbonyl, substituted or unsubstituted non-aromatic heterocyclyloxycarbonyl, substituted or unsubstituted aromatic carbocyclylsulfonyl, substituted or unsubstituted non-aromatic carbocyclylsulfonyl, substituted or unsubstituted aromatic heterocyclylsulfonyl, or substituted or unsubstituted non-aromatic heterocyclylsulfonyl;
R3 is hydrogen, cyano, substituted or unsubstituted carbamoyl, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted alkylsulfonyl, substituted or unsubstituted aromatic carbocyclyl, substituted or unsubstituted non-aromatic carbocyclyl, substituted or unsubstituted aromatic heterocyclyl, substituted or unsubstituted non-aromatic heterocyclyl, substituted or unsubstituted aromatic carbocyclylsulfonyl, substituted or unsubstituted non-aromatic carbocyclylsulfonyl, substituted or unsubstituted aromatic heterocyclylsulfonyl, or substituted or unsubstituted non-aromatic heterocyclylsulfonyl;
R4a and R4b are each independently hydrogen, halogen, hydroxy, cyano, substituted or unsubstituted alkyl, substituted or unsubstituted non-aromatic carbocycle, or substituted or unsubstituted non-aromatic heterocycle,
or, optionally, R4a and R4b are taken together with the adjacent carbon atom to form substituted or unsubstituted non-aromatic carbocycle or substituted or unsubstituted non-aromatic heterocycle;
R5 is each independently halogen, hydroxy, cyano, carboxy, substituted or unsubstituted carbamoyl, substituted or unsubstituted thiocarbamoyl, substituted or unsubstituted amidino, substituted or unsubstituted amino, substituted or unsubstituted ureido, substituted or unsubstituted guanidino, pentafluorothio, sulfo, substituted or unsubstituted sulfamoyl, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted alkyloxy, substituted or unsubstituted alkenyloxy, substituted or unsubstituted alkynyloxy, substituted or unsubstituted alkylcarbonyloxy, substituted or unsubstituted alkenylcarbonyloxy, substituted or unsubstituted alkynylcarbonyloxy, substituted or unsubstituted alkylcarbonyl, substituted or unsubstituted alkenylcarbonyl, substituted or unsubstituted alkynylcarbonyl, substituted or unsubstituted alkyloxycarbonyl, substituted or unsubstituted alkenyloxycarbonyl, substituted or unsubstituted alkynyloxycarbonyl, substituted or unsubstituted alkylsulfanyl, substituted or unsubstituted alkenylsulfanyl, substituted or unsubstituted alkynylsulfanyl, substituted or unsubstituted alkylsulfinyl, substituted or unsubstituted alkenylsulfinyl, substituted or unsubstituted alkynylsulfinyl, substituted or unsubstituted alkylsulfonyl, substituted or unsubstituted alkenylsulfonyl, substituted or unsubstituted alkynylsulfonyl, substituted or unsubstituted aromatic carbocyclyl, substituted or unsubstituted non-aromatic carbocyclyl, substituted or unsubstituted aromatic heterocyclyl, substituted or unsubstituted non-aromatic heterocyclyl, substituted or unsubstituted aromatic carbocyclyloxy, substituted or unsubstituted non-aromatic carbocyclyloxy, substituted or unsubstituted aromatic heterocyclyloxy, substituted or unsubstituted non-aromatic heterocyclyloxy, substituted or unsubstituted aromatic carbocyclylcarbonyloxy, substituted or unsubstituted non-aromatic carbocyclylcarbonyloxy, substituted or unsubstituted aromatic heterocyclylcarbonyloxy, substituted or unsubstituted non-aromatic heterocyclylcarbonyloxy, substituted or unsubstituted aromatic carbocyclylcarbonyl, substituted or unsubstituted non-aromatic carbocyclylcarbonyl, substituted or unsubstituted aromatic heterocyclylcarbonyl, substituted or unsubstituted non-aromatic heterocyclylcarbonyl, substituted or unsubstituted aromatic carbocyclyloxycarbonyl, substituted or unsubstituted non-aromatic carbocyclyloxycarbonyl, substituted or unsubstituted aromatic heterocyclyloxycarbonyl, substituted or unsubstituted non-aromatic heterocyclyloxycarbonyl, substituted or unsubstituted aromatic carbocyclylsulfanyl, substituted or unsubstituted non-aromatic carbocyclylsulfanyl, substituted or unsubstituted aromatic heterocyclylsulfanyl, substituted or unsubstituted non-aromatic heterocyclylsulfanyl, substituted or unsubstituted aromatic carbocyclylsulfinyl, substituted or unsubstituted non-aromatic carbocyclylsulfinyl, substituted or unsubstituted aromatic heterocyclylsulfinyl, substituted or unsubstituted non-aromatic heterocyclylsulfinyl, substituted or unsubstituted aromatic carbocyclylsulfonyl, substituted or unsubstituted non-aromatic carbocyclylsulfonyl, substituted or unsubstituted aromatic heterocyclylsulfonyl, substituted or unsubstituted non-aromatic heterocyclylsulfonyl, a group represented by the formula: -L1-N?S(?O)(—RS1)—RS2, a group represented by the formula: -L1-S(?O)(?N—RN)—RS1, a group represented by the formula: —N?S(?N—RN)(—RS1)—RS2, or a group represented by the formula: —S(?N—RN)2—RS1;
R6 is each independently halogen, hydroxy, cyano, carboxy, substituted or unsubstituted carbamoyl, substituted or unsubstituted thiocarbamoyl, substituted or unsubstituted amidino, substituted or unsubstituted amino, substituted or unsubstituted ureido, substituted or unsubstituted guanidino, pentafluorothio, sulfo, substituted or unsubstituted sulfamoyl, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted alkyloxy, substituted or unsubstituted alkenyloxy, substituted or unsubstituted alkynyloxy, substituted or unsubstituted alkylcarbonyloxy, substituted or unsubstituted alkenylcarbonyloxy, substituted or unsubstituted alkynylcarbonyloxy, substituted or unsubstituted alkylcarbonyl, substituted or unsubstituted alkenylcarbonyl, substituted or unsubstituted alkynylcarbonyl, substituted or unsubstituted alkyloxycarbonyl, substituted or unsubstituted alkenyloxycarbonyl, substituted or unsubstituted alkynyloxycarbonyl, substituted or unsubstituted alkylsulfanyl, substituted or unsubstituted alkenylsulfanyl, substituted or unsubstituted alkynylsulfanyl, substituted or unsubstituted alkylsulfinyl, substituted or unsubstituted alkenylsulfinyl, substituted or unsubstituted alkynylsulfinyl, substituted or unsubstituted alkylsulfonyl, substituted or unsubstituted alkenylsulfonyl, substituted or unsubstituted alkynylsulfonyl, substituted or unsubstituted aromatic carbocyclyl, substituted or unsubstituted non-aromatic carbocyclyl, substituted or unsubstituted aromatic heterocyclyl, substituted or unsubstituted non-aromatic heterocyclyl, substituted or unsubstituted aromatic carbocyclyloxy, substituted or unsubstituted non-aromatic carbocyclyloxy, substituted or unsubstituted aromatic heterocyclyloxy, substituted or unsubstituted non-aromatic heterocyclyloxy, substituted or unsubstituted aromatic carbocyclylcarbonyloxy, substituted or unsubstituted non-aromatic carbocyclylcarbonyloxy, substituted or unsubstituted aromatic heterocyclylcarbonyloxy, substituted or unsubstituted non-aromatic heterocyclylcarbonyloxy, substituted or unsubstituted aromatic carbocyclylcarbonyl, substituted or unsubstituted non-aromatic carbocyclylcarbonyl, substituted or unsubstituted aromatic heterocyclylcarbonyl, substituted or unsubstituted non-aromatic heterocyclylcarbonyl, substituted or unsubstituted aromatic carbocyclyloxycarbonyl, substituted or unsubstituted non-aromatic carbocyclyloxycarbonyl, substituted or unsubstituted aromatic heterocyclyloxycarbonyl, substituted or unsubstituted non-aromatic heterocyclyloxycarbonyl, substituted or unsubstituted aromatic carbocyclylsulfanyl, substituted or unsubstituted non-aromatic carbocyclylsulfanyl, substituted or unsubstituted aromatic heterocyclylsulfanyl, substituted or unsubstituted non-aromatic heterocyclylsulfanyl, substituted or unsubstituted aromatic carbocyclylsulfinyl, substituted or unsubstituted non-aromatic carbocyclylsulfinyl, substituted or unsubstituted aromatic heterocyclylsulfinyl, substituted or unsubstituted non-aromatic heterocyclylsulfinyl, substituted or unsubstituted aromatic carbocyclylsulfonyl, substituted or unsubstituted non-aromatic carbocyclylsulfonyl, substituted or unsubstituted aromatic heterocyclylsulfonyl, substituted or unsubstituted non-aromatic heterocyclylsulfonyl, a group represented by the formula: -L1-N?S(?O)(—RS1)—RS2, a group represented by the formula: -L1-S(?O)(?N—RN)—RS1, a group represented by the formula: —N?S(?N—RN)(—RS1)—RS2, or a group represented by the formula: —S(?N—RN)2—RS1;
R7a is each independently hydrogen, halogen, hydroxy, cyano, substituted or unsubstituted amino, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted alkyloxy, substituted or unsubstituted alkenyloxy, substituted or unsubstituted alkynyloxy, substituted or unsubstituted alkylsulfonyl, substituted or unsubstituted alkenylsulfonyl, substituted or unsubstituted alkynylsulfonyl, substituted or unsubstituted aromatic carbocyclyl, substituted or unsubstituted non-aromatic carbocyclyl, substituted or unsubstituted aromatic heterocyclyl, substituted or unsubstituted non-aromatic heterocyclyl, substituted or unsubstituted aromatic carbocyclyloxy, substituted or unsubstituted non-aromatic carbocyclyloxy, substituted or unsubstituted aromatic heterocyclyloxy, substituted or unsubstituted non-aromatic heterocyclyloxy, substituted or unsubstituted aromatic carbocyclylsulfonyl, substituted or unsubstituted non-aromatic carbocyclylsulfonyl, substituted or unsubstituted aromatic heterocyclylsulfonyl, or substituted or unsubstituted non-aromatic heterocyclylsulfonyl, and
R7b is each independently hydrogen, halogen, hydroxy, cyano, substituted or unsubstituted amino, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted alkyloxy, substituted or unsubstituted alkenyloxy, substituted or unsubstituted alkynyloxy, substituted or unsubstituted alkylsulfonyl, substituted or unsubstituted alkenylsulfonyl, substituted or unsubstituted alkynylsulfonyl, substituted or unsubstituted aromatic carbocyclyl, substituted or unsubstituted non-aromatic carbocyclyl, substituted or unsubstituted aromatic heterocyclyl, substituted or unsubstituted non-aromatic heterocyclyl, substituted or unsubstituted aromatic carbocyclyloxy, substituted or unsubstituted non-aromatic carbocyclyloxy, substituted or unsubstituted aromatic heterocyclyloxy, substituted or unsubstituted non-aromatic heterocyclyloxy, substituted or unsubstituted aromatic carbocyclylsulfonyl, substituted or unsubstituted non-aromatic carbocyclylsulfonyl, substituted or unsubstituted aromatic heterocyclylsulfonyl, or substituted or unsubstituted non-aromatic heterocyclylsulfonyl,
or, optionally, R7a and R7b attached to the same carbon atom are taken together with the adjacent carbon atom to form substituted or unsubstituted non-aromatic carbocycle or substituted or unsubstituted non-aromatic heterocycle;
R8 is hydrogen or substituted or unsubstituted alkyl;
R9 is hydrogen, substituted or unsubstituted amino, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted alkylcarbonyl, substituted or unsubstituted alkenylcarbonyl, substituted or unsubstituted alkynylcarbonyl, substituted or unsubstituted alkyloxycarbonyl, substituted or unsubstituted alkenyloxycarbonyl, substituted or unsubstituted alkynyloxycarbonyl, substituted or unsubstituted alkylsulfonyl, substituted or unsubstituted alkenylsulfonyl, substituted or unsubstituted alkynylsulfonyl, substituted or unsubstituted aromatic carbocyclyl, substituted or unsubstituted non-aromatic carbocyclyl, substituted or unsubstituted aromatic heterocyclyl, substituted or unsubstituted non-aromatic heterocyclyl, substituted or unsubstituted aromatic carbocyclylcarbonyl, substituted or unsubstituted non-aromatic carbocyclylcarbonyl, substituted or unsubstituted aromatic heterocyclylcarbonyl, substituted or unsubstituted non-aromatic heterocyclylcarbonyl, substituted or unsubstituted aromatic carbocyclyloxycarbonyl, substituted or unsubstituted non-aromatic carbocyclyloxycarbonyl, substituted or unsubstituted aromatic heterocyclyloxycarbonyl, substituted or unsubstituted non-aromatic heterocyclyloxycarbonyl, substituted or unsubstituted aromatic carbocyclylsulfonyl, substituted or unsubstituted non-aromatic carbocyclylsulfonyl, substituted or unsubstituted aromatic heterocyclylsulfonyl, or substituted or unsubstituted non-aromatic heterocyclylsulfonyl;
L1 is each independently a single bond, alkylene, or C(?O);
RS1 and RS2 are each independently hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted aromatic carbocyclyl, substituted or unsubstituted non-aromatic carbocyclyl, substituted or unsubstituted aromatic heterocyclyl, or substituted or unsubstituted non-aromatic heterocyclyl, or, optionally, RS1 and RS2 bonding to the same sulfur atom are taken together with the sulfur atom to form substituted or unsubstituted non-aromatic heterocycle;
RN is each independently hydrogen, cyano, substituted or unsubstituted carbamoyl, substituted or unsubstituted alkyl, substituted or unsubstituted alkylcarbonyl, substituted or unsubstituted alkyloxycarbonyl, substituted or unsubstituted aromatic carbocyclyl, substituted or unsubstituted non-aromatic carbocyclyl, substituted or unsubstituted aromatic heterocyclyl, substituted or unsubstituted non-aromatic heterocyclyl, substituted or unsubstituted aromatic carbocyclylcarbonyl, substituted or unsubstituted non-aromatic carbocyclylcarbonyl, substituted or unsubstituted aromatic heterocyclylcarbonyl, or substituted or unsubstituted non-aromatic heterocyclylcarbonyl;
m is an integer of 0 to 5;
n is an integer of 0 to 5; and
p is an integer of 1 to 6,or its pharmaceutically acceptable salt.

US Pat. No. 10,335,400

TREATMENT OF TAUOPATHIES WITH MGLUR5 ANTAGONISTS

The Research Foundation f...

1. A method of treating Parkinsonism-dementia complex of Guam, comprising the step of administering a pharmaceutically effective amount of an mGluR5 antagonist to a subject in need thereof to minimize a tau hyperphosphorylation in a brain thereof, wherein the mGluR5 antagonist is 2-methyl-6-(phenylethynyl) pyridine.

US Pat. No. 10,335,399

CHROMANE, ISOCHROMANE AND DIHYDROISOBENZOFURAN DERIVATIVES AS MGLUR2—NEGATIVE ALLOSTERIC MODULATORS, COMPOSITIONS, AND THEIR USE

1. A compound having the structure:

US Pat. No. 10,335,396

METHODS OF REVERSING AUTONOMIC NERVOUS SYSTEM DAMAGE

1. A method for reducing parasympathetic excess (PE) in a subject in need thereof, comprising:administering to said subject rifaximin, wherein rifaximin is administered for 10-14 days; a polyunsaturated omega-3 fatty acid, wherein the polyunsaturated omega-3 fatty acid comprises DHA in a daily concentration range selected from: about 2,000-4,000 mg, or about 3,000 mg; and olive oil, wherein the olive oil is administered daily in an amount selected from: about 5 ml to about 100 ml, about 10 ml to about 75 ml, about 15 ml to about 50 ml, about 20 ml to about 40 ml, or about 25 ml;
providing VNS (vagal nerve stimulation) to the subject, wherein the VNS is provided transcutaneously using electrical stimulation, wherein the electrical stimulation is achieved by clipping electrodes across the tragus of an ear and inducing an electrical current with a transcutaneous electrical nerve stimulation (TENS) unit; and
placing said subject on an intermittent fasting regimen, wherein the intermittent fasting regimen comprises fasting for multiple days but not on consecutive days; and
wherein the prevalence of parasympathetic excess (PE) is decreased.

US Pat. No. 10,335,394

PROCESSES FOR PREPARING DOLUTEGRAVIR AND CABOTEGRAVIR AND ANALOGUES THEREOF

Lek Pharmaceuticals d.d.,...

1. A process for preparing a compound of formula (I) or a salt thereof
wherein
A represents CH2 or CH2—CH2,
R represents H, C1-C4 alkyl or unsubstituted or substituted phenyl,
X represents O, S, or N—R5, wherein R5 is H or C1-C4 alkyl,
Z represents hydroxy, C1-C4 alkoxy, phenoxy, benzoxy, —NH—Ar or—NH—CH2—Ar,
wherein Ar represents unsubstituted or substituted phenyl, and
* represents a chirality center, which is of (R) or (S) configuration,
the process comprising the steps of
(a) providing a compound of formula (II) or a salt thereof,

wherein A, R, X, Z, and * have the same meaning as above and
Y represents Cl or O—Ra,
wherein Ra represents C1-C4 alkyl or benzyl,
and
(b) carrying out a chemical transformation to obtain the compound of formula (I) and/or a salt thereof,
wherein the transformation is carried out in the presence of a hydroxide and methanol and/or ethanol.

US Pat. No. 10,335,393

NUCLEAR TRANSPORT MODULATORS AND USES THEREOF

Biogen MA Inc., Cambridg...

1. A compound of formula I:
or a pharmaceutically acceptable salt thereof, wherein:
R1 is selected from hydrogen and C1-C4 alkyl;
R2 is selected from O; and
R3 is —C1-C6 alkyl, wherein R3 is optionally and independently substituted with one or more substituents selected from the group consisting of —OH, —SH, nitro, halogen, amino, cyano, C1-C12 alkyl, C2-C12 alkenyl or C2-C12 alkynyl group, C1-C12 alkoxy, C1-C12 haloalkyl, C1-C12 haloalkoxy and C1-C12 alkyl sulfanyl.

US Pat. No. 10,335,392

CYCLIC COMPOUNDS USEFUL AS MODULATORS OF TNF ?

Bristol-Myers Squibb Comp...

1. A compound of Formula (I)
or a salt thereof, wherein:
Ring A is 3- to 5-membered carbocyclic ring or 3- to 6-membered heterocyclic ring;
X is CR1 or N;
Y is —(CR5R5)m—;
Z is —(CR5R5)n—;
m is zero, 1 or 2;
n is zero, 1 or 2; provided that m+n is zero, 1, or 2;
R1 is H, halo, —CN, C1-4 alkyl, C1-4 haloalkyl, or C1-4 alkoxy;
R2 is H, R1a, C1-6 haloalkyl, C2-6 alkenyl substituted with zero to 6 R1a, C2-6 alkynyl substituted with zero to 4 R1a, —(CRgRg)r(3- to 14-membered carbocyclyl substituted with zero to 3 R1a), —(CRgRg)r(aryl substituted with zero to 3 R1a), —(CRgRg)r(5- to 7-membered heterocyclyl substituted with zero to 3 R1a), or —(CRgRg)r(mono- or bicyclic heteroaryl substituted with zero to 3 R1a);
R3 is H, halo, —CN, —CF3, —OCF3, —NO2, C1-6 alkyl substituted with zero to 6 R1a, —(CRgRg)rORe, —(CRgRg)rNRcRc, —(CRgRg)rS(O)pRb, —(CRgRg)r(3- to 14-membered carbocyclyl substituted with zero to 3 R1a), —(CRgRg)r(aryl substituted with zero to 3 R1a), —(CRgRg)r(5- to 7-membered heterocyclyl substituted with zero to 3 R1a), or —(CRgRg)r(monocyclic or bicyclic heteroaryl substituted with zero to 3 R1a);
R4 is H, halo, —CN, C1-4 alkyl, C1-4 haloalkyl, or C1-4 alkoxy;
each R5 is independently H, halo, —CN, C1-6 alkyl substituted with zero to 6 Rh, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, —(CRgRg)rC(O)Rb, —(CRgRg)rC(O)ORb, —(CRgRg)rC(O)NRcRc, —(CRgRg)rORe, —(CRgRg)rOC(O)Rb, —(CRgRg)rOC(O)NRcRc, —(CRgRg)rOC(O)ORd, —(CRgRg)rNRcRc, —(CRgRg)rNRbC(O)Rd, —(CRgRg)rNRbC(O)ORd, —(CRgRg)rNRbC(O)NRcRc, —(CRgRg)rNRbS(O)pRd, —(CRgRg)rS(O)pRb, —(CRgRg)rS(O)pNRcRc, —(CRgRg)r(3- to 14-membered carbocyclyl substituted with zero to 3 R1a), —(CRgRg)r(aryl substituted with zero to 3 R1a), —(CRgRg)r(5- to 7-membered heterocyclyl substituted with zero to 3 R1a), or —(CRgRg)r(mono- or bicyclic heteroaryl substituted with zero to 3 R1a); or two R5 along with the carbon atom to which they are attached form C?O, C?NORb, or 3- to 6-membered spirocarbocyclic or spiroheterocyclic ring substituted with zero to 3 Ri;
R6 and R8 are independently H, halo, —OH, —CN, C1-5 alkyl, C1-5 hydroxyalkyl, C1-5 haloalkyl, C1-5 alkoxy, —NRxRx, —OC(O)NRxRx, —NRxC(O)ORy, —NRxC(O)Ry, —(CRgRg)r(3- to 14-membered carbocyclyl substituted with zero to 3 R1a), —(CRgRg)r(aryl substituted with zero to 3 R1a), —(CRgRg)r(5- to 10-membered heterocyclyl substituted with zero to 3 R1a), or —(CRgRg)r(mono- or bicyclic heteroaryl substituted with zero to 3 R1a);
each R7 is independently halo, —OH, —CN, C1-5 alkyl, C1-5 hydroxyalkyl, C1-5 haloalkyl, —NRxRx, C1-5 alkoxy, —OC(O)NRxRx, —NRxC(O)ORy, —NRxC(O)Ry, —(CRgRg)r(3- to 14-membered carbocyclyl substituted with zero to 3 R1a), —(CRgRg)r(aryl substituted with zero to 3 R1a), —(CRgRg)r(5- to 10-membered heterocyclyl substituted with zero to 3 R1a), or —(CRgRg)r(mono- or bicyclic heteroaryl substituted with zero to 3 R1a);
R9 is —(CRgRg)r(3- to 14-membered carbocyclyl substituted with zero to 3 R1a), —(CRgRg)r(aryl substituted with zero to 3 R1a), —(CRgRg)r(5- to 10-membered heterocyclyl substituted with zero to 3 R1a), or —(CRgRg)r(mono- or bicyclic heteroaryl substituted with zero to 3 R1a);
R10 is H, C1-6 alkyl, or C1-6 haloalkyl;
or R9 and R10 together with the carbon atom to which they are attached form a 5- to 6-membered spirocarbocyclic or spiroheterocyclic ring, substituted with zero to 6 Ri;
each R1a is independently F, Cl, Br, —CN, C1-6 alkyl substituted with zero to 6 Ra, C3-6 cycloalkyl substituted with zero to 6 Ra, C1-3 alkoxy substituted with zero to 6 Ra, C1-3 haloalkoxy, 5- to 7-membered heterocyclyl substituted with zero to 6 Ra, aryl substituted with zero to 6 Ra, mono- or bicyclic heteroaryl substituted with zero to 6 Ra, —C(O)Rb, —C(O)ORb, —C(O)NRcRc, —OC(O)Rb, —OC(O)NRcRc, —OC(O)ORd, —NRcRc, —NRbC(O)Rd, —NRbC(O)ORd, —NRbS(O)pRd, —NRbC(O)NRcRc, —NRbS(O)pNRcRc, —S(O)pRb, —S(O)pNRcRc, or —C(O)NRb(CH2)1-3NRcRc;
each Ra is independently halo, —CN, —OH, —NO2, —NH2, C1-3 alkyl, C1-3 fluoroalkyl, C2-4 alkenyl, C2-4 alkynyl, C1-3 alkoxy, C1-3 fluoroalkoxy, —(CH2)rC(O)OH, —C(O)(C1-3 alkyl), —C(O)O(C1-4 alkyl), —OC(O)(C1-3 alkyl), —NH(C1-3 alkyl), —N(C1-3 alkyl)2, —C(O)NH(C1-3 alkyl), —OC(O)NH(C1-3 alkyl), —NHC(O)NH(C1-3 alkyl), —C(?NH)(NH2), C3-7 carbocyclyl, aryl, 5- to 7-membered heterocyclyl, mono- or bicyclic heteroaryl, —O(aryl), —O(benzyl), —O(heterocyclyl), —S(O)p(C1-3 alkyl), —S(O)p(aryl), —S(O)p(heterocyclyl), —NHS(O)2(aryl), —NHS(O)2(heterocyclyl), —NHS(O)2NH(aryl), —NHS(O)2NH(heterocyclyl), —NH(aryl), —NH(heterocyclyl), —NHC(O)(aryl), —NHC(O)(C1-3 alkyl), —NHC(O)(heterocyclyl), —OC(O)(aryl), —OC(O)(heterocyclyl), —NHC(O)NH(aryl), —NHC(O)NH(heterocyclyl), —OC(O)O(C1-3 alkyl), —OC(O)O(aryl), —OC(O)O(heterocyclyl), —OC(O)NH(aryl), —OC(O)NH(heterocyclyl), —NHC(O)O(aryl), —NHC(O)O(heterocyclyl), —NHC(O)O(C1-3 alkyl), —C(O)NH(aryl), —C(O)NH(heterocyclyl), —C(O)O(aryl), —C(O)O(heterocyclyl), —N(C1-3 alkyl)S(O)2(aryl), —N(C1-3 alkyl)S(O)2(heterocyclyl), —N(C1-3 alkyl)S(O)2NH(aryl), —N(C1-3 alkyl)S(O)2NH(heterocyclyl), —N(C1-3 alkyl)(aryl), —N(C1-3 alkyl)(heterocyclyl), —N(C1-3 alkyl)C(O)(aryl), —N(C1-3 alkyl)C(O)(heterocyclyl), —N(C1-3 alkyl)CO2H —N(C1-3 alkyl)C(O)NH(aryl), —(CH2)0-3C(O)NH(heterocyclyl), —OC(O)N(C1-3 alkyl)(aryl), —OC(O)N(C1-3 alkyl)(heterocyclyl), —N(C1-3 alkyl)C(O)O(aryl), —N(C1-3 alkyl)C(O)O(heterocyclyl), —C(O)N(C1-3 alkyl)(aryl), —C(O)N(C1-3 alkyl)(heterocyclyl), —NHS(O)2N(C1-3 alkyl)(aryl), —NHS(O)2N(C1-3 alkyl)(heterocyclyl), —NHP(O)2N(C1-3 alkyl)(aryl), —NHC(O)N(C1-3 alkyl)(aryl), —NHC(O)N(C1-3 alkyl)(heterocyclyl), —N(C1-3 alkyl)S(O)2N(C1-3 alkyl)(aryl), —N(C1-3 alkyl)S(O)2N(C1-3 alkyl)(heterocyclyl), —N(C1-3 alkyl)C(O)N(C1-3 alkyl)(aryl), —N(C1-3 alkyl)C(O)N(C1-3 alkyl)(heterocyclyl), or —Si(C1-3 alkyl)3; or two Ra attached to the same carbon atom form ?O;
each Rb is independently H, C1-6 alkyl substituted with zero to 6 Rf, C3-7 cycloalkyl substituted with zero to 6 Rf, mono- or bicyclic heterocyclyl substituted with zero to 6 Rf, aryl substituted with zero to 3 Rf, or mono- or bicyclic heteroaryl substituted with zero to 3 Rf;
each Rc is independently H, C1-6 alkyl substituted with zero to 6 Rf, C3-7 cycloalkyl substituted with zero to 6 Rf, mono- or bicyclic heterocyclyl substituted with zero to 6 Rf, aryl substituted with zero to 3 Rf, or mono- or bicyclic heteroaryl substituted with zero to 3 Rf; or when attached to the same nitrogen, two Rc along with the nitrogen atom to which they are attached form 4- to 8-membered heterocyclic ring substituted with zero to 3 Rg;
each Rd is independently H, C1-6 alkyl substituted with zero to 6 Rf, C3-7 cycloalkyl substituted with zero to 6 Rf, mono- or bicyclic heterocyclyl substituted with zero to 6 Rf, aryl substituted with zero to 3 Rf, or mono- or bicyclic heteroaryl substituted with zero to 3 Rf;
each Re is independently H, C1-6 alkyl substituted with zero to 6 Rf, C1-3 haloalkyl, C3-7 cycloalkyl substituted with zero to 6 Rf, mono- or bicyclic heterocyclyl substituted with zero to 6 Rf, aryl substituted with zero to 3 Rf, or mono- or bicyclic heteroaryl substituted with zero to 3 Rf;
each Rf is independently H, halo, —OH, —CN, C1-6 alkyl substituted with zero to 6 Ra, C1-3 alkoxy, C3-7 cycloalkyl substituted with zero to 6 Ra, mono- or bicyclic heterocyclyl substituted with zero to 6 Ra, aryl substituted with zero to 3 Ra, or mono- or bicyclic heteroaryl substituted with zero to 3 Ra;
each Rg is independently H, F, —OH, —CN, C1-3 alkyl, —CF3, or phenyl;
each Rh is independently —OH or halo;
each Ri is independently H, halo, —CN, —OH, C1-3 alkyl, C1-3 fluoroalkyl, or C1-3 alkoxy; or two Ri attached to the same carbon atom of the spirocarbocyclic or spiroheterocyclic ring, form ?O; or two Ri attached to neighboring carbon atoms of the spirocarbocyclic or spiroheterocyclic ring, form a benzo ring along with the carbon atoms to which they are attached, said benzo ring substituted with zero to 4 Rf;
each Rx is independently H or C1-5 alkyl;
each Ry is independently C1-5 alkyl;
each p is independently zero, 1, or 2;
q is zero, 1, or 2; and
each r is independently zero, 1, 2, 3, or 4.

US Pat. No. 10,335,388

COMBINATION THERAPY OF A HIF-2-ALPHA INHIBITOR AND AN IMMUNOTHERAPEUTIC AGENT AND USES THEREOF

PELOTON THERAPEUTICS, INC...

1. A method of treating cancer in a subject in need thereof, comprising administering to said subject an effective amount of a HIF-2? inhibitor in combination B with an immunotherapeutic agent, wherein the cancer is selected from the group consisting of melanoma, renal cell carcinoma, and colorectal cancer, wherein the immunotherapeutic agent is a PD-1 inhibitor or a CTLA-4 inhibitor, and wherein the HIF-2? inhibitor is a compound of Formula I-C:
or a pharmaceutically acceptable salt thereof, wherein:
X is CR5 or N;
Y is CR6 or N;
Z is —O—, —S—, —C(HR7)—, —N(R8)— or absent;
R1 is alkyl, heteroalkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, acyl or cyano;
R4 is nitro, halo, cyano, alkyl, cycloalkyl, heteroaryl, carboxyl, sulfinyl, sulfonamidyl, sulfonyl or sulfoximinyl;
R5, R6, R7 and R8 are independently hydrogen, halo, hydroxy, cyano, alkyl or alkoxy;
R11 is hydrogen, halo, hydroxy, alkoxy or amino;
R12 is hydrogen, alkyl, alkenyl or alkynyl; or R11 and R12 in combination form oxo or oxime;
each of R13 is independently selected from the group consisting of hydrogen, fluoro, chloro, hydroxy, alkyl and heteroalkyl; or two R13s and the carbon atom(s) to which they are attached form a 3- to 8-membered cycloalkyl or heterocycloalkyl moiety; and
n is 0, 1, 2, 3 or 4.

US Pat. No. 10,335,383

OAT FRACTIONS WITH ENHANCED AVENANTHRAMIDE CONCENTRATION AND METHODS OF MAKING

The Quaker Oats Company, ...

1. A food product comprising an infrared-treated oat flour made by exposing a pre-treatment oat flour to infrared energy so that the infrared-treated oat flour has a higher concentration of total Avenanthramides than the pre-treatment oat flour,wherein the amount of Avenanthramides in the food product is sufficient to provide a health benefit to a human upon oral ingestion of the food product by the human,
wherein the concentration of total Avenanthramides in the infrared-treated oat flour is higher than the concentration of total Avenanthramides that occurs naturally in the pre-treatment oat flour,
wherein the infrared-treated oat flour has been treated by exposure to infrared energy so that the concentration of total Avenanthramides in the infrared-treated oat flour is increased by at least 5 wt. % relative to the concentration of total Avenanthramides in the pre-treatment oat flour, wherein the pre-treatment oat flour is untreated for Avenanthramides enhancement,
wherein the exposure includes exposing the pre-treatment oat flour to from 2 to 15 kJ of infrared energy per gram of the pre-treatment oat flour,
wherein the infrared-treated oat flour is untreated with enzymes to increase the concentration of Avenanthramides, and
wherein the infrared-treated oat flour is untreated with fungal agents to increase the concentration of Avenanthramides.

US Pat. No. 10,335,382

USE OF HYDROGEN SULFIDE SYNTHESIS INHIBITORS FOR CANCER THERAPY

THE BOARD OF REGENTS OF T...

1. A cystathionine-?-synthase (CBS) inhibitor having a chemical structure of Formula I,
wherein R1 is a 3-pentyl group, wherein the compound inhibits CBS.

US Pat. No. 10,335,379

ORAL DOSAGE FORMS OF KETAMINE

Develco Pharma Schweiz AG...

1. An oral dosage form comprising ketamine or a pharmaceutically acceptable salt or solvate thereof,wherein the dosage form provides an in vitro release of ketamine, when measured according to the USP Basket Method I in 0.1M HCl at 37° C. at 100 rpm, of 0 to 40% after 2 hours, of 10 to 70% after 4 hours, of 30 to 85% after 6 hours and of 45 to 100% after 8 hours,
wherein the dosage form provides an in vitro release of ketamine, when measured according to the USP 1 Basket Method in 0.1M HCl at 100 rpm, after one hour at 37° C., in an aqueous solution containing 20% by volume of ethanol, in a ratio of less than 2:1 relative to the amount of ketamine released, so measured, after one hour at 37° C. in an ethanol-free aqueous solution,
wherein the dosage form is a multi-particulate controlled release tablet,
wherein the tablet comprises pellets each containing
i) a core comprising
1 to 30 wt. % inert beads,
5 to 400 mg and 1 to 40 wt. % ketamine hydrochloride,
0.01 to 10 wt. % binder, and
0 to 10 wt. % glidant, and
ii) a release control layer comprising
1 to 40 wt. % of a release control substance coated upon the core, wherein the release control substance is a water insoluble polymer,
0.01 to 10 wt % pore builder,
0.01 to 10 wt. % plasticizer, and
0 to 15 wt. % glidant, and
wherein the pellets are contained in an external phase comprising
carboxymethyl cellulose, optionally in the form of a salt, as a pharmaceutically acceptable excipient,
20 to 85 wt. % filler,
0 to 3 wt. % lubricant, and
0 to 5 wt. % glidant,
wherein the tablet optionally comprises an external film coating, and
wherein all wt. % are based on the total weight of the tablet, without the film coating.

US Pat. No. 10,335,374

TABLET COMPOSITION FOR ANTI-TUBERCULOSIS ANTIBIOTICS

University System of Geor...

1. A pharmaceutical composition comprisingi. one or more front line antibiotics used in the treatment of the bacterial infection Mycobacterium tuberculosis;
ii. sucrose, wherein its mass percent is a minimum of about one percent and a maximum of fifty percent of the total composition mass;
iii. copper (Cu), which is present in an amount from at least about one percent to about forty percent of the total mass of the composition; and
iv. a polyethylene glycol (PEG) polymer wherein its mass percent is a minimum of at least five percent and a maximum of 90% of the total composition mass.

US Pat. No. 10,335,372

COMPOSITIONS WITH MODIFIED NUCLEASES TARGETED TO VIRAL NUCLEIC ACIDS AND METHODS OF USE FOR PREVENTION AND TREATMENT OF VIRAL DISEASES

Jacob G. Appelbaum, Gain...

1. A method for treating a viral disease in a subject, the method comprising:administering to the subject a composition for destruction of targeted nucleic acids inside biological cells, the composition comprising:
a core carrier comprising a plurality of first multivalent molecular scaffolds and a plurality of second multivalent molecular scaffolds, each of the first and second multivalent molecular scaffolds being covalently bound to the core carrier, each first and second multivalent molecular scaffold comprising a polymer,
at least one of the first multivalent molecular scaffolds further comprising a plurality of cell membrane permeating peptides covalently bound to the first multivalent molecular scaffold for effective internalization of the composition into cytoplasm of the biological cells, wherein the first multivalent molecular scaffolds are nuclease-free,
at least one of the second multivalent molecular scaffolds comprising a plurality of nucleic acid targeting ligands covalently bound to the second multivalent molecular scaffold that is capable of binding specific sequences on targeted nucleic acids inside the biological cells, at least one nuclease covalently bound to the second multivalent molecular scaffold that is capable of destruction of the targeted nucleic acids that are bound to the nucleic acid targeting ligands inside the biological cells.

US Pat. No. 10,335,361

COSMETIC PROCESS FOR MAKING-UP AND/OR CARING FOR THE SKIN AND/OR THE LIPS

1. A cosmetic process for making up and/or caring for skin and/or lips, comprising applying a cosmetic composition to the skin and/or the lips, the cosmetic composition comprising, in a physiologically acceptable medium:supramolecular polymer having the formula:

the supramolecular polymer being present in an amount in a range of from 0.3 to 40% by weight relative to a total weight of the composition; and
at least one hydrophobic film-forming polymer in an amount in a range of from 0.2 to 20% by weight relative to a total weight of the composition, the hydrophobic film-forming polymer being a vinyl polymer bearing a carbosiloxane dendrimer-based unit having a formula selected from the group consisting of:

US Pat. No. 10,335,358

HAIR COSMETIC

KAO CORPORATION, Tokyo (...

1. A hair cosmetic comprising ingredients (A) and (B):(A) from 0.37 to 5 mass % of a cationic polymer having a charge density of 5.0 meq/g or more and 6.2 meq/g or less; and
(B) from 0.61 to 2.52 mass % of an anionic polysaccharide derivative wherein a part of the hydrogen atoms of the hydroxyl group of a polysaccharide compound having a constituent unit represented by formula (1) are substituted with —(CH2)mCOO? group, wherein m is an integer of 1 to 5, at an average substitution degree of from 0.7 to 0.85 per constituent unit, and wherein optionally a part of the hydrogen atoms of the remaining hydroxyl groups are substituted with linear or branched C1-40 alkyl groups, alkylene groups, or a combination thereof;
wherein:
a mass ratio of ingredient (A) to ingredient (B), (A)/(B), is from 0.2 to 1.5;
a viscosity of ingredient (B) in a 2 mass % aqueous solution at 25° C. is from 3 mPa·s to 298 mPa·s; and
formula (1) is:
wherein each R?, independently, represents a C2-4 linear alkylene group optionally substituted with a hydroxyl group or a C2-4 branched alkylene group optionally substituted with a hydroxyl group, and n represents a number by which the average number of added moles of R?O per constituent unit is 0 to 10.

US Pat. No. 10,335,351

PERSONAL CARE ARTICLES AND METHODS

1. A compliant personal cleansing article, comprising:a) cleansing composition, comprising a rheology modifier and from about 10% to about 70%, by weight of the composition, of a synthetic surfactant; and
b) a water penetrable first substrate surrounding the composition; wherein the article has a compliance of about 1.50 kg/mm or less.

US Pat. No. 10,335,350

PACIFIER WHICH HELPS WEAN TODDLERS OFF PACIFIERS

1. A pacifier, intended for use with infants of suitable age to wean a child from continued pacifier use without anger, anxiety or stress, comprising:a) a teat structure for allowing the child to suck upon it;
b) a mouth shield arranged generally perpendicularly to the teat and joined therewith so as to be generally inseparable therefrom, said mouth shield defining an outermost edge of the pacifier, said mouth shield comprising apertures extending through said mouth shield, said apertures being disposed radially outward from the teat structure; and
c) a flexible sheet having bristle structures projecting therefrom, said bristle structures covering an entire surface of said mouth shield from an outermost edge of the mouth shield to a position adjacent the teat, wherein said flexible sheet comprises apertures extending through said flexible sheet, wherein the apertures of the mouth shield are axially aligned with said apertures of the flexible sheet, wherein said bristle structures project in the same direction as the teat to slightly irritate the face and mouth of the child during use thereby discouraging continued use of the pacifier.

US Pat. No. 10,335,349

PRESCRIPTION DRUG ABUSE PREVENTION SYSTEM

Addinex Technologies, Inc...

1. A container for restricting access to controlled objects comprising:a housing with a central axis, a top, and a bottom, and having an access port therein;
an object storage drum within the housing, the drum being rotatable about the axis relative to the housing and having a plurality of dispensing positions including a start dispensing position and an end dispensing position, each dispensing position allowing access to a respective dispensing portion of the drum through the access port;
a combination element rotatable about the axis relative to the housing, the combination element being rotationally lockable to the drum and having a surface with a plurality of channels formed therein;
a plurality of pegs engaging the channels in the surface, each respective peg being movable between a respective plurality of predefined peg positions, the housing having indicia thereon indicating the respective pluralities of predefined peg positions;
when the combination element is rotationally locked to the drum the plurality of channels defining for each respective peg a traversal path through which the respective peg can travel as the drum is rotated from the start dispensing position to the end dispensing position, the traversal path for each respective peg requiring the respective peg to be in a first predefined peg position to permit rotation of the drum between a respective first pair of adjacent dispensing positions and a second predefined peg position to permit rotation of the drum between a respective second pair of adjacent dispensing positions, wherein rotation of the drum requires the plurality of pegs to follow the respective traversal paths;
the particular positions of the plurality of pegs required to permit rotation of the drum from a current dispensing position to a next dispensing position defining a transition peg combination for the current dispensing position.

US Pat. No. 10,335,348

FILLING NEEDLE FOR USE IN A TUBE LAYER FOR TRANSFERRING A FLOWABLE MEDIUM, IN PARTICULAR A PHARMACEUTICAL PRODUCT

1. A filling needle for use in a tube set for transferring a flowable medium, the filling needle comprising:a needle end for temporary insertion into a filling vessel;
a connector end for connecting the filling needle to a filling device via which the medium can be supplied to the filling needle;
an inner tube layer made of silicone, defining an inner tube lumen;
an outer reinforcing tube layer made of a plastic reinforcing material, encasing the inner tube lumen; and
a bonding agent between the inner tube layer and the reinforcing tube layer,
wherein the bonding agent includes bonding bodies which mechanically bond the two tube layers, and
wherein the filling needle on the whole is made entirely of plastic.

US Pat. No. 10,335,346

OPTICAL TECHNIQUES FOR THE MEASUREMENT OF CHEST COMPRESSION DEPTH AND OTHER PARAMETERS DURING CPR

PHYSIO-CONTROL CANADA SAL...

1. A device for monitoring chest compressions during the administration of cardiopulmonary resuscitation to a patient, comprising:a three-dimensional image optical sensor attached to a wrist band configured to be worn around a wrist of a rescuer administering cardiopulmonary resuscitation to the patient, the optical sensor configured to sense a distance, for a plurality of pixels of the optical sensor, between the optical sensor and an object in an environment surrounding the optical sensor, the distance sensed throughout motion of a chest compression administered by the rescuer during cardiopulmonary resuscitation and the object in the environment monitored for changes that are related to the depth of the administered chest compressions, the optical sensor positioned to move with the motion of the chest compression;
processing circuitry configured to receive the sensed distance from optical sensor and further configured to:
generate a depth map from the sensed distance between the optical sensor and the object in the environment of the sensor; and
extract depth information of the chest compression based on the depth map.

US Pat. No. 10,335,345

VIBRATION DEVICE USING SOUND PRESSURE, AND HUMAN BODY STIMULATION APPARATUS COMPRISING SAME

EVOSONIC CO., LTD., Wonj...

1. A vibration device for generating vibration using sound pressure, the vibration device comprising:a lower body being open at a top thereof, and defining an accommodation space therein;
a lower bracket being open at a top and a bottom thereof, and provided in the accommodation space of the lower body;
a magnetic body fixedly provided on a bottom surface of the lower body to generate a magnetic force;
a bobbin provided in the lower bracket to be located above the magnetic body;
a voice coil provided on an outer circumference of the bobbin to interact with the magnetic body;
a damper provided on an upper surface of the bobbin, coupled to an upper surface of an edge of the lower bracket, and vertically generating vibration by interaction between the magnetic body and the voice coil;
a connection member coupled at a lower end thereof to a central portion of the damper and a central portion of the upper surface of the bobbin, and coupled at an upper end thereof with a vibration probe for stimulating a human body, thus transmitting vibration from the damper to the vibration probe;
an upper body covering an open top of the lower body, the connection member being inserted into a center on an upper surface of the upper body; and
an upper bracket being open at a bottom thereof, and accommodated in an internal space of the upper body to be coupled with the lower bracket, the connection member being inserted into an upper surface of the upper bracket.

US Pat. No. 10,335,344

MASSAGE APPLIANCE, MANUFACTURING METHOD THEREOF, AND MANUFACTURING APPARATUS

TENGA CO., LTD., Tokyo (...

1. A manufacturing method of a massage appliance comprising:providing a motor, a vibrating piece configured to be driven by the motor, and a case configured to accommodate the motor and the vibrating piece and including a case opening at least in one place;
accommodating the motor and the vibrating piece in the case;
preparing a soft cover which includes a cover opening at a position corresponding to the case opening, the soft cover configured to surround an outer surface of the case;
coating the soft cover on the outer surface of the case to make the case opening communicate with the cover opening;
forming a space between the outer surface of the case and an inner surface of the soft cover by tightly fixing a peripheral edge of the cover opening over the entire peripheral of a peripheral edge of the case opening;
introducing a negative pressure into the space;
injecting a liquid resin as an undiluted solution of a soft resin into the space, the soft resin being interposed between the outer surface of the case and the soft cover, and being of a material which is more flexible than the soft cover, and being thicker than the soft cover; and
curing the liquid resin to become the soft resin.

US Pat. No. 10,335,343

METHOD AND DEVICE FOR TREATING FEMALE PELVIC NERVE DYSFUNCTION

ParaPatch, Inc., Campbel...

1. A device adapted for providing an inhibitory effect on a bladder of a female person, comprising a patch having a substantially planar skin-contacting surface and sized and configured to be secured directly over and covering a clitoris without covering a urethra of said person, the patch formed of a backing sheet of flexible material with an adhesive layer comprising an adhesive on one side of the backing sheet, the adhesive layer removably connected to a release layer, the patch configured when applied to stimulate the clitoris to inhibit bladder discharge.

US Pat. No. 10,335,342

METHOD, SYSTEM, AND APPARATUS FOR TREATMENT OF BINOCULAR DYSFUNCTIONS

New Jersey Institute of T...

1. A method for remediating visual symptoms in a user with binocular dysfunction, the method comprising:rendering a visual therapy video game on one or more displays;
controlling accommodative and proximal vergence stimulation of a user's eyes via the visual therapy video game; and
asymmetrical stimulating to a left eye or a right eye of the user via the visual therapy video game based on peak velocity differences between the left and right eyes.

US Pat. No. 10,335,340

MOBILE DENTAL INTELLIGENCE CENTER

Dr. Kevin T. Prince, Hon...

1. A portable dental and medical unit comprising:a wheelbase;
a plurality of 360 degree rotatable wheels extending from the wheelbase and configured to movably support the unit on an underlying support surface;
a central support beam extending upward from the wheelbase;
a rechargeable power supply positioned within a power supply compartment and a retractable wall plug mounted on the central support beam adjacent said wheelbase;
a cylindrical housing supported by the central support beam and spaced apart from the wheelbase, wherein the cylindrical housing is vertically adjustable with respect to the wheelbase by a unit height adjustor;
the cylindrical housing has a bottom and a top and comprises series of elements including:
a waste water reservoir with a reservoir drain positioned adjacent the bottom;
a clean water reservoir with a reservoir drain position adjacent the bottom;
a suction pump positioned adjacent said waste water reservoir or said clean water reservoir;
an air compressor positioned adjacent said waste water reservoir or said clean water reservoir;
a mouthwash reservoir positioned adjacent said suction pump;
a toothbrush rinser positioned adjacent said mouth wash reservoir;
a biofilm contamination sensor located near the waste water reservoir;
a water pump;
a unit control module; and
a unit supply platform positioned within a unit supply storage compartment adjacent the mouth wash reservoir, toothbrush rinser and unit control module and near a top of the cylindrical housing, wherein the unit supply platform includes a series of inter-unit supply line attachment ports and a series of USB ports;
a protrusion, including dual solar panels positioned on a surface thereof, extends upward from the top of the cylindrical housing and includes a foldable handle with slip-resistant grip mounted thereto and a 360 degree swivel digital display mounted thereto;
wiring and inter-unit supply lines and hoses extend through the central support beam and are configured to attach to at least one of the series of elements, the rechargeable power supply or an electric toothbrush, a computer monitor or an air-water syringe and connector;
wherein the 360 degree swivel digital display is configured to display information measured by one of said series of elements or an external health monitoring device including a digital blood pressure cuff, a digital thermometer, a digital pulse oximeter or a digital intra oral and extra oral camera connected to one of the series of USB ports.

US Pat. No. 10,335,339

PORTABLE EXAMINATION CHAIR

1. A pivoting examination chair mechanism for an examination chair related to a substantially immovable examination tool, comprising:a rotation mechanism portion rotating about a first vertical axis;
a rotation arm integral with, and extending from, said rotation mechanism portion; and,
a chair support portion attached proximate a distal end of said rotation arm offset from a rotating base portion including a chair gimbal located on a set of legs extending upwards from said rotation arm, wherein said chair gimbal rotates around a second vertical axis and wherein said first vertical axis and said second vertical axis are substantially parallel to one another for moving said rotation arm through 180°, so that said pivoting examination chair is movable about said first vertical axis for providing a clear access area to said substantially immovable examination tool.

US Pat. No. 10,335,338

APPARATUS FOR APPLYING MULTI-DIMENSIONAL TRACTION TO THE SPINAL COLUMN

Nichols Therapy Systems L...

1. A physical medicine table for treating a patient's spine comprising:a. a frame having a longitudinal axis and a transverse axis;
a plurality of support portions that are configured to receive a patient, wherein the plurality of support portions are attached to the frame and selectively spaced apart along the longitudinal axis of the frame;
c. wherein a first support portion comprises:
i. a first longitudinal movement subframe slidably mounted to the frame;
ii. a first lateral movement subframe slidably mounted to the first longitudinal movement subframe and configured to move in the transverse axis;
iii. a rotational adjustment subframe mounted to the first lateral movement subframe, the rotational adjustment subframe configured to selectively rotate;
d. a traction system comprising:
i. a first lateral actuator centrally mounted to the first longitudinal movement subframe and centrally disposed under the rotational adjustment subframe;
ii. wherein the traction system is configured to exert a first lateral force upon the first lateral movement subframe without rotating the first lateral movement subframe and without rotating the first support portion, wherein the first lateral force is perpendicular to the longitudinal axis of the frame, and the traction system is further configured to exert a longitudinal force upon at least one of the plurality of support portions; and
e. a control system that selectively controls the first lateral force and the longitudinal force exerted by the traction system.

US Pat. No. 10,335,337

INCUBATOR WITH THERMOREGULATING ARRANGEMENT FOR NEWBORNS SUFFERING FROM PATHOLOGIES

1. An incubator with a thermoregulating arrangement for newborns suffering from pathologies, comprising a closed compartment which externally has a plurality of openings and an access door, while internally it is comprised of a horizontal partition defining an upper part adapted to receive a newborn in a resting position and a lower part provided with thermoregulating means that produce air flows, adapted to maintain the newborn at required temperatures, said upper part comprises an outer hood separated from an inner hood with an upper external circulation channel being defined therebetween, whereinthe upper external circulation channel being in fluid communication with said lower part through a low pressure lower external circulation channel and a high pressure lower external circulation channel,
the thermoregulating means comprise a heating resistor, a baffle and a cold/heat generator,
said partition is provided with a first head and a second head and at least one mattress tray between both heads,
the first head includes a low pressure internal air channel and the second head includes a high pressure internal air channel, with the low pressure internal air channel and the high pressure internal air channel being arranged at opposite sides of the at least one mattress tray and the thermoregulating means and in fluid communication with opposite ends of the upper part defining an internal air flow flowing from said high pressure internal air channel towards the low pressure internal air channel and extending underneath and concentrically to the inner hood and spaced apart from the at least one mattress tray, thus forming a bubble around the at least one mattress tray.

US Pat. No. 10,335,336

INCUBATOR

Atom Medical Corporation,...

1. An incubator comprising:an incubator base that is provided on a main strut;
a bed base that is provided on the incubator base and on which a mattress is placed; and
a cassette tray accommodation space which is formed between the incubator base and the bed base, wherein the cassette tray accommodation space comprises at least three tray loading/unloading ports selected from: a front tray loading/unloading port, a rear tray loading/unloading port, a left tray loading/unloading port, and a right tray loading/unloading port.

US Pat. No. 10,335,335

AIR MATTRESS FOR GATCH BED

Paramount Bed Co., Ltd., ...

1. An air mattress placed on a plurality of bottoms including a back bottom, comprising:a plurality of air cells extending to a bed width direction and being arranged in parallel in a bed longitudinal direction;
an air supplying unit for performing supply and discharge of air for each of the air cells; and,
a control unit that inflates and deflates the air cells by increasing and decreasing a pressure of air to be supplied to each of the air cells, wherein
the control unit is configured to:
detect a back tilt angle of the back bottom;
inflate an air cell, of the plurality of air cells, that is in a deflated state when the back tilt angle has reached a first angle; and
perform, after the air cell has been inflated, an inflating and deflating operation of a proper subset of the air cells until a rising operation of the back bottom ends.

US Pat. No. 10,335,334

EMERGENT SITUATION NOTIFICATION DURING TRANSPORT OF A PATIENT SUPPORT APPARATUS

Hill-Rom Services, Inc., ...

1. A patient-support status system comprisinga patient support apparatus adapted to support a patient thereon, the patient support apparatus including control circuitry including memory storing the identity of the patient support apparatus,
a user interface coupled to the control circuitry and monitoring for a user input associated with an emergent situation of the patient during transportation of the patient on the patient support apparatus,
a location-detection system coupled to the control circuitry of the patient support apparatus, the location detection system communicating with location identifiers in a healthcare facility to provide a real-time location of the patient support apparatus as the patient support apparatus moves through the healthcare facility, and
a transceiver coupled to the control circuitry, the transceiver communicating the patient support apparatus identity and the real-time location to a remote computer in response to receipt of the user input.

US Pat. No. 10,335,333

MECHANICS OF THE BED SIDERAIL

LINET SPOL. S R.O., Slan...

1. A bed comprising:a frame,
a patient support connected to the frame,
at least two posts connected on one side of the bed to the frame of the bed,
at least one siderail with a frame,
a locking mechanism positioned between the two posts and at least one part of the frame of the siderail, and
a linkage for manipulation of the siderail with respect to the patient support, the linkage comprising a first arm and a second arm; the first arm having a first end connected in a rotating manner by a fixed pivot to the frame of the bed and a second end connected in a rotating manner to a center of the second arm; the second arm having a first end connected in a rotating manner by a sliding coupling to the frame of the bed and a second end connected in a rotating manner to the bed siderail.

US Pat. No. 10,335,332

TOP BAR ACCESSORY FOR WALKER

GANM, LLC, Paris, TN (US...

1. An accessory package for a walker, the accessory package comprising:a cross bar having opposite first and second ends; and
first and second pivot connections configured to connect to the respective first and second ends of the cross bar to the respective laterally opposite sides of a frame of the walker, each of the pivot connections comprising;
an eyelet portion adapted and configured to receive one of the first and second ends of the cross bar, the eyelet portion having a stem with a stem axis extending along a length of the stem; and
an upright piece adapted and configured to be removable attachable to the respective lateral opposite sides of the frame with mechanical fasteners, the upright piece having an outer shape formed to conform to a framework of the walker such that when the upright piece is removably connected to the framework of the walker with the mechanical fasteners, the upright piece is constrained from relative movement with the framework of the walker, the upright piece being adapted and configured to receive the stem and permit adjustment of the length of the stem received within the upright piece along the stem axis, the upright piece being adapted and configured to allow relative rotation of the stem within the upright piece about the stem axis thereby allowing pivoting of the upright piece about the stem axis;
further comprising a locking cap adapted and configured to be fitted to the respective first and second ends of the cross bar to secure the cross bar within the eyelet portion.

US Pat. No. 10,335,331

POWERED WHEELCHAIR, WHEELCHAIR POWERING DEVICE AND METHOD

INVENTIT PRODUCTS, INC., ...

1. A wheelchair powering device configured for integration with a foldable wheelchair, the device comprising:an attachment mechanism configured to attach the powering device to the wheelchair;
a motor;
a roller member operatively coupled to the motor such that operation of the motor drives rotation of the roller member; and
an adjustment mechanism operatively coupled to the roller member, the adjustment mechanism being configured to control movement of the roller member into and out of contact with a wheel of the wheelchair,
wherein the adjustment mechanism includes a lever, wherein the roller member passes through a roller member bracket, and wherein the lever is operatively coupled to the roller member bracket such that adjustment of the lever causes rotation of the roller member bracket to displace the roller member,
wherein the wheelchair powering device is configured to provide for the wheelchair to be folded with the wheelchair powering device integrated with the foldable wheelchair, and
wherein, upon integration of the wheelchair powering device with the wheelchair, the wheelchair is configured to be powered interchangeably by both operation by the powering device and manual operation.

US Pat. No. 10,335,330

MOTOR-DRIVEN CHAIR STEERED BY SEAT ROTATION

TRAVELSYS4U LTD., Ramat ...

1. A motor-driven chair for propelling a user over an underlying surface, the chair comprising:(a) a seat element having support surfaces for supporting the user sitting in a seat-facing direction;
(b) a seat pole extending downwards from said seat element for supporting said seat element, said seat pole defining a vertical axis;
(c) a drive wheel rotatable about a horizontal axis of rotation so as to define a direction of forward motion perpendicular to said axis of rotation, said drive wheel being located beneath said seat element substantially on said vertical axis, said drive wheel being mechanically linked to said seat pole so as to maintain said direction of forward motion aligned with said seat-facing direction so that rotation of said seat element about said vertical axis causes a corresponding rotation of said direction of forward motion;
(d) a motor in driving connection to said drive wheel so as to drive said drive wheel to rotate about said horizontal axis of rotation, and thereby propel the chair in the seat-facing direction;
(e) a stabilizer assembly mechanically linked to said seat pole, said stabilizer assembly comprising a set of stabilizer wheels mounted on a support structure for supporting said seat pole in a vertical orientation, said stabilizer assembly allowing rotation of said seat pole about said vertical axis relative to said support structure; and
(f) a suspension arrangement associated with said seat pole, said drive wheel and said stabilizer assembly, said suspension arrangement being configured to distribute a load of the user sitting stably on said seat element so as to maintain a predefined range of proportions between a load supported by said drive wheel and a load supported by said stabilizer wheels.

US Pat. No. 10,335,329

POWERED COTS

Ferno-Washington, Inc., ...

1. A cot comprising:a support frame comprising a front end, a back end and a pair of parallel lateral side members extending between the front end and the back end, the pair of parallel lateral side members defining tracks therein;
a pair of front legs each of which is slidingly engaged with and pivotally coupled to the support frame through a respective front carriage member that is disposed within one of the tracks, wherein each front leg comprises at least one front wheel;
a pair of back legs each of which is slidingly engaged with and pivotally coupled to the support frame through a respective back carriage member that is disposed within one of the tracks, wherein each back leg comprises at least one back wheel;
a front actuator sensor that detects whether the pair of front legs are in contact with a surface beneath the support frame or the pair of front legs are out of contact with the surface beneath the support frame;
a back actuator sensor that detects whether the pair of back legs are in contact with the surface beneath the support frame or the pair of back legs are out of contact with the surface beneath the support frame; and
a cot actuation system responsive to a received signal from at least one of the front and back actuator sensors during at least one of loading the cot onto or unloading the cot from a loading surface, the cot actuation system comprising a front actuator that is cooperative with each front carriage member to move the at least one wheel of each of the front legs relative to the at least one wheel of each of the back legs during at least one of loading the cot onto or unloading the cot from a loading surface and a back actuator that is cooperative with each back carriage member to move the at least one wheel of each of the back legs relative to the at least one wheel of each of the front legs during at least one of loading the cot onto or unloading the cot from a loading surface.

US Pat. No. 10,335,328

HARNESS SYSTEM FOR PATIENT TRANSPORT APPARATUS

Stryker Corporation, Kal...

1. A patient transport apparatus for transporting a patient, said patient transport apparatus comprising:a support structure having a base and a patient support surface;
wheels coupled to said base;
a harness system operable by a user to secure the patient to said patient support surface, said harness system comprising:
a plurality of harness assemblies configured to be coupled to said support structure, each of said harness assemblies comprising:
a connector; and
a flexible restraint member coupled to said connector, said flexible restraint member comprising a fabric and a coating covering said fabric, said flexible restraint member comprising stitches securing first and second sections of said fabric together at a joint,
wherein said fabric and said stitches are configured to be unexposed to contaminants during use.

US Pat. No. 10,335,327

SPINE BOARD

1. A spine board, comprising: a backboard, wherein at least a portion of the backboard is transparent; and a mirror that is coupled to the backboard via one or more coupling devices, the mirror being substantially the same size as the backboard, the coupling devices facilitating the mirror being at least partially removable from the backboard, and the mirror having a reflective surface facing the backboard when the mirror is coupled to an underside of the backboard, wherein at least partially removing the mirror from the backboard facilitates visual assessment of a posterior surface of a patient occupying the spine board using a reflection, via the mirror, of the posterior surface of the patient through the portion of the backboard that is transparent.

US Pat. No. 10,335,326

SMART NURSING CONSUMABLE AND PHYSIOLOGICAL MONITORING DEVICE USING THE SAME

Sinopulsar Technology Inc...

1. A smart nursing consumable, comprising:an absorbent body, comprising a water-absorbing layer and a water draining layer disposed above the water-absorbing layer; and
a sensor module, disposed on the water draining layer and comprising a plurality of wires, a first porous sheet, a second porous sheet and a conductive pad, wherein the wires are disposed between the first porous sheet and the second porous sheet, the first porous sheet is disposed adjacent to the water-absorbing layer, and the conductive pad is connected to the wires through pores of the second porous sheet.

US Pat. No. 10,335,324

ABSORBENT ARTICLES WITH CHANNELS

1. An absorbent article comprising:a front waist region;
a rear waist region;
a crotch region positioned intermediate the front waist region and the rear waist region;
a liquid permeable material;
a liquid impermeable material;
an absorbent core disposed at least partially intermediate the liquid permeable material and the liquid impermeable material and comprising an absorbent material, wherein the absorbent material is positioned within a core wrap, wherein the core wrap forms a C-wrap, wherein the absorbent material comprises at least 85% of superabsorbent polymers by weight of the absorbent material, wherein the absorbent core defines a first channel substantially free of the superabsorbent polymers, wherein the first channel extends substantially through the thickness of the absorbent material, wherein a first side of the core wrap is joined to a second side of the core wrap in a portion of the first channel, and wherein the first channel extends from the front waist region to the rear waist region;
a liquid management system positioned at least partially intermediate the liquid permeable material and the core wrap, wherein the liquid management system is substantially free of any superabsorbent polymers; and
a liquid distribution system, wherein the liquid distribution system defines a second channel, wherein the liquid distribution system is positioned intermediate the liquid management system and the core wrap, and wherein the second channel extends substantially through the thickness of the liquid distribution system.

US Pat. No. 10,335,323

METHOD FOR PRODUCING DISPOSABLE WORN ARTICLE

Zuiko Corporation, Osaka...

1. A method for producing a disposable worn article including an around-torso member configured to cover a torso of a wearer and extend in a girth direction and an absorbent body configured to cover a crotch of the wearer, the method comprising the steps of:applying an adhesive on an elastic member extending in a carrying direction;
sandwiching the elastic member between two sheets of continuous non-woven fabric having a pair of side edge portions extending in the carrying direction, and bonding together the two sheets of continuous non-woven fabric along a part of a middle portion between the pair of side edge portions via the adhesive applied on the elastic member so that the two sheets of continuous non-woven fabric are laid on each other, thereby producing a continuous member; and
thermally welding together the two sheets of continuous non-woven fabric along the pair of side edge portions, which are closer to edges of the continuous member than the middle portion bonded by the adhesive, wherein:
the sandwiching step further comprises forming an unbonded central region without adhesive, the central region extending in the carrying direction and dividing the middle portion in two, and
the thermally welding step further comprises thermally welding the two sheets of continuous non-woven fabric together along the central region,
the method further comprises:
a step of cutting and dividing the continuous member, after the thermally welding step, along a virtual cutting line extending in the carrying direction in the central region into a first divided non-woven fabric and a second divided non-woven fabric;
a step of changing a positional relationship between the first and the second divided non-woven fabrics in a width direction perpendicular to the carrying direction by moving the first and the second divided non-woven fabrics relative to each other in the width direction so that the first and the second divided non-woven fabrics are spaced apart from each other in the width direction;
a step of placing absorbent bodies, after the changing step, so that each of the absorbent bodies bridges between the first and the second divided non-woven fabrics and so that each of the absorbent bodies is laid on a portion of the first divided non-woven fabric and on a portion of the second divided non-woven fabric, while the first and the second divided non-woven fabrics are carried in parallel to each other in the carrying direction, thereby producing a continuous laminate; and
a step of cutting the continuous laminate, after the placing step, in the width direction between the absorbent bodies adjacent to each other so that the continuous laminate is cut into an individual disposable worn article, wherein
the step of changing the positional relationship between the first and the second divided non-woven fabrics is carried out by crossing the first and the second divided non-woven fabrics so that the pair of side edge portions are placed between a first cut edge of the first divided non-woven fabric along the cutting line and a second cut edge of the second divided non-woven fabric along the cutting line, thereby the pair of side edge portions being spaced apart from each other while opposing each other in the width direction.

US Pat. No. 10,335,322

ADHESIVE SUPPORT DEVICES AND METHODS OF MAKING AND USING THEM

LightSide MD, LLC, Los A...

1. A method of making an adhesive support device having a three-dimensional shape, the method comprising:placing a planar sheet of material between a first tool and a second tool, wherein the sheet of material extends in a first plane and wherein the material has an elastic modulus of greater than 0.4 GPa;
stamping the planar sheet of material between the first tool and the second tool to deform a portion of the material so that it forms a cavity portion extending out of the first plane;
securing an adhesive substrate to a base region extending in the first plane wherein the base region is a portion of the planar sheet peripheral to the cavity portion; and
laser cutting one or more walls of the cavity portion using a laser that is oriented perpendicular to the first plane.

US Pat. No. 10,335,321

BREATHABLE INTERFACE SYSTEM FOR TOPICAL REDUCED PRESSURE

KCI Licensing, Inc., San...

1. A dressing for treating tissue comprising:an elongate applicator having a first end with a first width and a second end having a second width less than a first width, the elongate applicator having an aperture in the first end;
a porous pad;
a fabric layer having a first end located adjacent the aperture between the porous pad and the elongate applicator, the fabric layer extending from the first end to the second end of the elongate applicator;
a drape sealed to the elongate applicator and substantially enclosing the porous pad and the fabric layer; and
wherein the fabric layer has a second end is adapted to receive a reduced pressure from a conduit.

US Pat. No. 10,335,320

REDUCED-PRESSURE DRESSINGS, SYSTEMS, AND METHODS FOR USE WITH LINEAR WOUNDS

KCI Licensing, Inc., San...

1. A dressing assembly for treating a linear wound, comprising:a dressing bolster having a first side and a second, inward-facing side;
a comfort layer having a first side and a second, inward-facing side, the first side of the comfort layer coupled to the second, inward-facing side of the dressing bolster;
a first sealing member covering the dressing bolster;
a second sealing member covering a portion of the second, inward-facing side of the dressing bolster and extending outward from the dressing bolster, wherein a portion of the first sealing member is coupled to the second sealing member by an attachment device; and
a sealing ring disposed on and directly coupled to at least a portion of the second, inward-facing side of the comfort layer.

US Pat. No. 10,335,319

METHOD AND APPARATUS FOR CLEANING ISTHMUS OF EUSTACHIAN TUBE

Acclarent, Inc., Irvine,...

1. A method for cleaning an isthmus of a Eustachian tube (ET) of a patient using an instrument, wherein the instrument comprises a proximal portion, a distal portion, and a shaft extending therebetween, wherein the instrument further comprises a treatment feature disposed at the distal portion, the method comprising:(a) directing the instrument into an oro-nasal cavity of the patient;
(b) advancing at least the distal portion of the instrument into an opening of the ET;
(c) further advancing the instrument within the ET so that the treatment feature is disposed past, or is coincident with, the isthmus; and
(d) moving the treatment feature relative to the isthmus while atraumatically frictionally engaging the isthmus to thereby clean the isthmus by removing debris without damaging the isthmus.

US Pat. No. 10,335,318

LIGHT BLOCKING EYE COVER ATTACHABLE TO A PILLOW

1. An eye covering, comprising in combination:an elongate flexible sleeve having a hollow interior;
said sleeve flexible enough to be configured to wrap around a majority of a head of a wearer and against the head of the wearer;
said sleeve having an elongate form between a proximal end and a distal end;
said distal end and said proximal end free from coupling to other structures; and
said interior at least partially filled with a plurality of individual beads of media.

US Pat. No. 10,335,317

EYEWEAR HAVING MULTIPLE VENTILATION STATES

Oakley, Inc., Foothill R...

1. An assembly for attachment to an eyewear having a lens, the assembly being configured to transition between at least a first configuration and a second configuration, the assembly comprising:a subframe having a nose portion, wherein the subframe is configured to be positioned further apart from the lens in the second configuration than in the first configuration; and
an arm connected to the subframe, the arm configured to move between a first arm position in the first configuration and a second arm position in the second configuration, wherein moving the arm from the first arm position to the second arm position causes the assembly to transition from the first configuration to the second configuration;
wherein the assembly is configured to provide a low ventilation state in the first configuration with the subframe and the lens positioned closer together;
wherein the assembly is configured to provide a high ventilation state in the second configuration with the subframe and the lens positioned further apart from each other;
wherein the high ventilation state is configured to allow more ventilation between an eyewear and the face of the wearer than the low ventilation state.

US Pat. No. 10,335,316

CAPSULAR MEMBRANE TREATMENTS TO INCREASE ACCOMMODATIVE AMPLITUDE

1. An apparatus to treat an eye, the eye having a lens comprising a capsule, the apparatus comprising:a delivery device configured to be coupled to an intermediate portion of the capsule to deliver one or more of an energy or a substance to the intermediate portion of the capsule to stiffen the intermediate portion of the capsule; and
circuitry coupled to the delivery device to deliver the one or more of the energy or the substance to the eye to stiffen the intermediate portion of the capsule.

US Pat. No. 10,335,315

BI-RADIAL PATIENT INTERFACE

ALCON LENSX, INC.

1. A patient interface for an ophthalmic system, comprising:an attachment portion, configured to attach the patient interface to a distal end of the ophthalmic system;
a contact portion, configured for docking the patient interface to an eye; and
a contact element, coupled to the contact portion, comprising a pre-formed shape that includes, prior to contact with a surface of a cornea of the eye as part of the docking of the patient interface to the eye:
a transparent central portion with a central radius of curvature Rc,
a transparent peripheral portion with a peripheral radius of curvature Rp, wherein Rc is smaller than Rp, and
an edge structure where the transparent central portion and the transparent peripheral portion are joined, the edge structure configured to laterally stretch a central-cornea of the eye during the docking, the edge structure having a central diameter Dc in the range of 6-12 mm.

US Pat. No. 10,335,314

DELIVERY SYSTEM AND METHOD OF USE FOR THE EYE

IVANTIS, INC., Irvine, C...

1. An apparatus comprising:an inserter device comprising an interior space and a shaft disposed in the interior space; and
an intraocular implant adapted to self-retain to an inner wall of Schlemm's canal, the intraocular implant being disposed in the interior space of the inserter device, the intraocular implant comprising:
a proximal portion sized and shaped to reside within an anterior chamber of the eye, the proximal portion comprising a proximal opening;
a distal portion sized and shaped to reside within Schlemm's canal of the eye, the distal portion comprising a distal opening and a surface facing the proximal opening and configured to engage an inner wall of Schlemm's canal; and
a passageway extending in a straight line from the proximal opening to the distal opening to conduct fluid from the anterior chamber to Schlemm's canal,
the shaft being adapted to advance the intraocular implant out of the interior space and through an inner wall of Schlemm's canal.

US Pat. No. 10,335,313

METHOD FOR REMOVING COLORED SPOTS TO WHITEN THE EYE

1. A method for whitening an eye by removing pigmented lesions, nevi, and colored spots from the conjunctiva of the eye, comprising the steps of:topically applying an anesthetic to the eye;
preparing the ocular surface with a disinfectant;
inserting an eyelid speculum;
selecting an area of the conjunctiva to be removed, including a colored portion;
selecting and activating a motorized conjunctiva remover, which includes a body and an eye attachment with a tip, and which has a long axis along the length of the conjunctiva remover;
applying the tip of the eye attachment to the selected area of the conjunctiva to continuously wear away the conjunctiva until it is cleared of the colored portion;
deactivating the conjunctiva remover;
removing the eyelid speculum; and,
topically administering an antibiotic substance and an anti-inflammatory substance.

US Pat. No. 10,335,312

VAGINAL RING REMOVAL DEVICE AND METHODS

1. A device for removing an intravaginal drug delivery ring, the device comprising:an integral one-piece finger cot and a substantially rigid hook configured to remove said ring without injuring a vaginal cavity;
wherein said finger cot includes a finger opening, a closed end, a compression band, and an expandable sleeve;
wherein said hook extends away from said finger cot in a first direction and towards said finger cot in a second direction; and
wherein a distal end of said hook is aligned substantially parallel to a central axis of said finger opening and at an angle offset from said central axis.

US Pat. No. 10,335,311

ANTI-SNORING DEVICE

1. An anti-snoring device comprising:an elastic sheet including a first side, a second side, and an aperture, the second side including a first adhesive portion and a second adhesive portion; and
a tube including a first end, a second end, and a hollow interior, the first end of the tube disposed through the aperture of the elastic sheet, wherein the first end of the tube is coupled to the elastic sheet, such that the first end of the tube terminates at the first side of the elastic sheet and the second end of the tube extends a predetermined distance from the second side of the elastic sheet,
wherein, the second side of the elastic sheet is configured to be coupled to a user's face such that the first adhesive portion adheres to skin of the user below the user's nose and above the user's upper lip, the second adhesive portion adheres to the skin of the user below the user's lower lip, and the second end of the tube extends between the user's upper lip and lower lip into the interior of the user's mouth, the predetermined distance selected such that a portion of the upper lip is parted from a portion of the lower lip and the portion of the upper lip and the portion of the lower lip are prevented from touching while the second end of the tube is disposed in the interior of the user's mouth,
wherein, when the second side of the elastic sheet is coupled to the user's face, the elastic sheet is configured to draw the user's lower jaw toward the user's upper jaw to prevent the user from snoring while sleeping and the tube is configured with a predetermined outer circumference that enables the user's upper and lower lips to achieve a substantially closed position around the outer circumference of the tube and enables the user to breathe via the hollow interior of the tube.

US Pat. No. 10,335,310

APPARATUSES AND METHODS FOR DISRUPTING AND PREVENTING SNORE

1. An apparatus for disrupting or preventing snoring, the apparatus comprising:a bladder assembly comprising a sleeve assembly and an inflatable bladder configured to be received within the sleeve assembly, wherein the sleeve assembly comprises a plurality of rigid segments, each rigid segment being pivotally hinged to an adjacent rigid segment;
the inflatable bladder configured to:
inflate to expand the plurality of rigid segments outwardly along a longitudinal axis of the bladder assembly to raise an entire top surface of the bladder assembly substantially in parallel; and
deflate to lower the entire top surface of the bladder assembly substantially in parallel;
wherein a total time of inflation and deflation comprises one inflation cycle;
a conduit connecting the inflatable bladder to an air inflator, the air inflator for inflating the inflatable bladder;
a controller in communication with the air inflator, the controller configured to actuate the air inflator;
suspension components to suspend the air inflator inside a soundproof housing; and
an audio processor in communication with the controller, the audio processor being configured to detect sound waves including a snoring sound, and transmit control commands to the controller to actuate the air inflator to initiate the one inflation cycle once a trigger event is detected.

US Pat. No. 10,335,309

ADAPTABLE OSTOMY BASE PLATE

1. An ostomy base plate attachable around a stoma of a user and provided to allow a waste collecting bag to be attached to and removed from the ostomy base plate, the ostomy base plate comprising:a wafer having a hole adapted to be placed around the stoma of the user, and a distal side opposite of a proximal side, with the proximal side of the wafer including an adhesive that extends from an adhesive region around the hole to an outermost perimeter of the wafer, where the adhesive is adapted to secure the proximal side of the wafer to skin of the user around the stoma;
a coupling device provided on the distal side of the wafer and adapted to couple with the waste collecting bag, the coupling device surrounding the hole in the wafer; and
a connecting element having an inner periphery connected to the coupling device and an outer periphery connected to the distal side of the wafer;
wherein the connecting element extends away from the distal side of the wafer to separate a proximal side of the coupling device an offset distance away from the distal side of the wafer;
wherein the proximal side of the wafer is convex such that:
a) the adhesive region around the hole contacts the skin of the user when the hole is placed around the stoma of the user, and
b) the outermost perimeter of the wafer is located distal to a distal end of the coupling device to space the outermost perimeter of the wafer away from the skin of the user.

US Pat. No. 10,335,308

FLEXIBLE BARRIER FILMS CONTAINING CYCLIC OLEFINS

Avery Dennison Corporatio...

34. A method for reducing transmission of odorous species, the method comprising:providing at least one layer including a blend of cyclic olefin copolymers (COC), wherein the blend includes a semi-crystalline COC and a norbornene COC, wherein a total norbornene concentration of the norbornene COC in the at least one layer is from about 12% to about 60% by mole based upon the total moles of COCs in the layer;
forming a barrier film including the at least one layer including a blend of cyclic olefin copolymers (COC); and
positioning the barrier film between a source of odorous species and a user;
wherein the semi-crystalline cyclic olefin copolymer has a glass transition temperature of from about ?20° C. to about 20° C.

US Pat. No. 10,335,307

PENILE CONSTRICTION DEVICE

OVO JOINT VENTURE LLC, H...

1. A penile constriction device comprising:a ring-shaped body and an elongated head element having a length that is greater than its maximum width, wherein the head element extends lengthwise in a radial direction relative to the ring-shaped body;
wherein the ring-shaped body has an interior diameter sized to closely encircle a penis, and the head element is removably attached to the ring-shaped body; and
wherein the head element is disposed so that the head element can contact a clitoris during sexual intercourse when the ring-shaped body is positioned on the penis;
wherein the ring-shaped body has an outer peripheral portion at which the head element is provided;
wherein the head element extends in an essentially radial direction relative to the ring-shaped body;
wherein the ring-shaped body is provided with a coupling means for removably mounting the head element to the ring-shaped body; and
wherein the coupling means comprises a protruding portion extending away from the ring-shaped body and wherein the head element includes an opening adapted to accommodate the protruding portion.

US Pat. No. 10,335,306

SUPPORTER

KOWA CO., LTD, (JP) ADVA...

1. A supporter formed of a band-shaped member, the supporter comprising:a back-contact section that is arranged substantially at the center of the band-shaped member, and that is adapted to come in contact with a wearer's back region;
protruding sections that are arranged at both sides of the back-contact section;
a pair of auxiliary band sections that defines two band-shaped members having stretchability in a longitudinal direction and in which an annular ring is arranged to be slidable over each band-shaped member; and
a pair of adjustment band sections that defines two band-shaped members having stretchability lower than the stretchability of the auxiliary band sections,
wherein each protruding section includes a stretchable portion being in contact with the back-contact section and having stretchability in the longitudinal direction and a non-stretchable portion having no stretchability,
wherein both ends of the pair of auxiliary band sections are fixed so that the two band-shaped members cross each other on the back-contact section,
wherein each of the pair of adjustment band sections is slideably inserted into the annular rings arranged in the auxiliary band sections, and
wherein the pair of adjustment band sections includes:
a first adjustment band section in which one end of the band-shaped member is fixed to the non-stretchable portion of the right protruding section and an other end of the band-shaped member is able to be fastened to the non-stretchable portion of the right protruding section, and
a second adjustment band section in which one end of the band-shaped member is fixed to the non-stretchable portion of the left protruding section and an other end of the band-shaped member is able to be fastened to the non-stretchable portion of the left protruding section.

US Pat. No. 10,335,305

SELF-ACTIVATED LIFTING VEST WITH SENSORY-FEEDBACK AND METHODS OF USE THEREOF

Strong Arm Technologies, ...

1. A support device comprising:a garment configured to be worn by a user, the garment including a back plate having an upper portion and a lower portion, the back plate configured and positioned to extend vertically along a central portion of a back of the user such that the upper portion of the back plate is proximate to an upper central portion of the back and the lower central portion of the back plate is proximate to a lower portion of the back when the garment is worn by the user;
a pivot point located at the upper portion of the back plate; and
at least one sensory feedback element coupled to the lower portion of the back plate, the at least one sensory feedback element configured to press into the back of the user in response to a non-ergonomic lifting posture by the user during a lifting operation, wherein the non-ergonomic lifting posture includes bending at the waist with a hunched back.

US Pat. No. 10,335,304

PRESSING TOOL FOR PELVIC FLOOR MUSCLE GROUP

1. A pressing tool adapted for use with a pelvic floor muscle group of a human body comprising:a pressing tool main body having a length in a longitudinal direction adapted to be at least as long as a length between a pubis and a coccyx and having a width in a width direction with respect to the longitudinal direction that is adapted to be shorter than a length between an ischia, as a pair,
wherein a part of the pressing tool main body in the longitudinal direction is configured to be at least as long as the length between the pubis and the coccyx has a convex upper surface formed in a convex shape headed outward from the pressing tool main body,
wherein a convex lower surface is provided at a position opposed to the convex upper surface and the convex lower surface is formed in an arc having a curvature larger than the convex upper surface,
wherein the pressing tool for a pelvic floor muscle group is mounted to have a positional relationship in which the longitudinal direction corresponds to a front-back direction so that the convex upper surface may be located highest in the pressing tool main body and so that the longitudinal direction of the pressing tool main body may be along a seat surface, and the pressing tool is configured such that when the human body sits on the seat surface and mounts the convex upper surface, the convex upper surface is adapted to oppose the pubis and the coccyx,
wherein, as for the pressing tool main body, the convex upper surface has a hardness of 10 to 20, which is a value of the International Rubber Hardness Degree (IRHD) complying with JIS K 6253, when the pressing tool main body is in an initial state in which the pressing tool main body is subject to no external force and is not squashed, and has a hardness of 25 to 35, which is a value of the International Rubber Hardness Degree (IRHD) complying with JIS K 6253, when the pressing tool main body is subject to being squashed during use, and a height from the seat surface to the convex upper surface becomes a half of the height from the seat surface to the convex upper surface in the initial state, and
wherein the pressing tool main body has a hard portion made of a urethane resin and a soft portion made of a urethane resin.

US Pat. No. 10,335,303

INTRAGASTRIC DEVICE

Obalon Therapeutics, Inc....

1. A device for assisting a patient in swallowing an intragastric balloon, comprising:an elongate tube comprising a body and an elongate slit, the body having a through-bore extending from a first orifice of the elongate tube to a second orifice of the elongate tube, wherein the elongate slit extends through the body from the first orifice to the second orifice;
a gastric balloon assembly reversibly attached to the second orifice, the gastric balloon assembly comprising an inflation catheter engaged with a gastric balloon in a capsule and extending out of the first orifice, wherein the elongate slit is sized and shaped for the inflation catheter to pass therethrough, and wherein the gastric balloon assembly is attached to the first orifice by a press-fit;
a handle member; and
an engagement subassembly comprising a female portion and a male portion, wherein the engagement subassembly is configured and arranged for threading the inflation catheter into and engaging the elongate tube.

US Pat. No. 10,335,301

MODULAR HANDLE COMPRISING A TRIGGER WIRE ACTUATION MECHANISM FOR A PROSTHESIS DELIVERY DEVICE

Cook Medical Technologies...

1. A handle assembly for a prosthesis delivery device comprising:a stationary main handle having a proximal end and a distal end and an outer surface extending therebetween;
a first helical groove formed in at least a portion of the outer surface of the main handle;
a first trigger wire actuation mechanism disposed about the main handle and rotatably moveable relative to the main handle;
a first trigger wire operatively connected to the first trigger wire actuation mechanism, the first trigger wire having a prosthesis capture condition and a prosthesis release condition;
wherein movement of the first trigger wire actuation mechanism causes movement of the first trigger wire thereby moving the first trigger wire from the prosthesis capture condition to the prosthesis release condition; and
a first ratcheting mechanism that permits rotation of the first trigger wire actuation mechanism in a first direction and prevents rotation of the first trigger wire actuation mechanism in a second direction, wherein the first ratcheting mechanism is a ratchet ring disposed between the outer surface of the main handle and an inner surface of the first trigger wire actuation mechanism.

US Pat. No. 10,335,300

SYSTEM FOR DEPLOYING A CAPACITIVE SHAPE MEMORY CATHETERIZATION DEVICE AND METHODS FOR USE THEREWITH

Memory Effect Medical, LL...

1. A system for deploying a shape memory catheterization device within a patient, the system comprising: a shape memory polymer that includes a plurality of conductive plates, wherein the shape memory polymer has a transition temperature that is higher than a normal body temperature of the patient; a catheter having a delivery rod for endovascular insertion of the shape memory polymer; a heat source for heating the shape memory polymer above the transition temperature, wherein the heat source utilizes a microwave source that is separate from the shape memory polymer, wherein heating the shape memory polymer above the transition temperature causes the shape memory polymer to undergo a shape transformation from a catheterization shape to a transformed shape, and further causes a change in a capacitance of the shape memory polymer as a result of the shape transformation; a transformation data generator, coupled to the catheter, that includes a power source for driving a detection circuit that monitors the change in the capacitance of the shape memory polymer based on monitoring at least one of: a charging time or a discharging time of the plurality of conductive plates of the shape memory polymer, and generates transformation data based on the change in the capacitance of the shape memory polymer resulting from the shape transformation of the shape memory polymer; a heating control generator that utilizes a processing device and memory to generate a control signal for controlling the microwave source based on the transformation data, wherein the heating control generator generates the control signal to discontinue the heating of the shape memory polymer by the microwave source when the transformation data indicates the shape transformation of the shape memory polymer from the catheterization shape to the transformed shape; and wherein the delivery rod includes a plurality of electrodes that are electrically coupled to a portion of the shape memory polymer to detect the change in capacitance of the shape memory polymer, wherein the delivery rod is removed from the patient in response to the transformation data indicating the shape transformation of the shape memory polymer from the catheterization shape to the transformed shape, and wherein the plurality of electrodes are decoupled from the shape memory polymer to enable removal of the delivery rod from the body of the patient while allowing the shape memory polymer to remain in the body of the patient.

US Pat. No. 10,335,299

VESSEL PROSTHESIS

Terumo Corporation, Toky...

1. A vascular prosthesis comprising:a plurality of wires woven together to form a tubular shape with a plurality of loops on each end of the tubular shape; said plurality of loops being arranged in an alternating pattern of longer loops and shorter loops;
each of said plurality of loops terminating with a cap having a cylindrical body and a rounded distal end; said cap comprising a trimmed first wire end, a trimmed second wire end, and a metal tube positioned flush over and melted together with said trimmed first wire end and said trimmed second wire end.

US Pat. No. 10,335,298

STENT

1. A stent having a distal end and a proximal end and a longitudinal axis, the stent comprising:a first circumferential row arranged near the proximal end and extending substantially perpendicular to the longitudinal axis;
a second circumferential row arranged near the distal end and extending substantially perpendicular to the longitudinal axis;
a plurality of struts configured to longitudinally stabilize the stent; and
an intermediate section extending at an angle relative to the longitudinal axis and being axially interposed between and directly connected to the first circumferential row and the second circumferential row, the intermediate section having uniform apex angles and uniform apex amplitude along a length thereof to form a uniform apex geometry the stent having an insertion configuration and a deployed configuration, the stent configured to maintain a length that is substantially constant as the stent transforms from the insertion configuration to the deployed configuration.

US Pat. No. 10,335,297

STENT AND STENT DELIVERY DEVICE

Terumo Corporation, Toky...

1. An implant device comprising:a first tubular layer having a first porosity and being woven from at least one wire composed of a shape memory metal; and,
a second tubular layer having a second porosity and being woven from at least one wire composed of a shape memory metal; said second tubular layer being located in said first tubular layer; and,
a connecting member woven through both said first tubular layer and said second tubular layer;
wherein said first tubular layer and said second tubular layer have substantially the same pitch and substantially no clearance between the layers.

US Pat. No. 10,335,295

LINER FOR A PROSTHESIS CONFIGURED TO EVACUATE A VOLUME BETWEEN THE LINER AND A SOCKET USING A VALVE AND PUMP CHAMBER EACH POSITIONED WITHIN THE LINER

1. A liner for a prosthesis, comprising:an inner face;
an outer face;
at least one flow channel having at least one inlet opening and at least one outlet opening, the at least one flow channel extending between the inner face and the outer face;
a one-way valve arranged in the at least one flow channel in such a manner that a medium can flow through the one-way valve only from the at least one inlet opening to the at least one outlet opening, the one-way valve being configured to evacuate a volume between a distal end of the liner and a prosthesis socket of the prosthesis.

US Pat. No. 10,335,294

SYSTEMS AND METHODS FOR AUTOMATICALLY TUNING POWERED PROSTHESIS IMPEDANCE CONTROL PARAMETERS

North Carolina State Univ...

1. A system for tuning powered prosthesis impedance control parameters, comprising:a powered prosthesis comprising:
a joint,
a motor mechanically coupled to the joint, the motor being configured to drive the joint,
a plurality of sensors configured to measure a plurality of gait parameters associated with a subject, and
an impedance controller configured to output a control signal for adjusting a torque of the motor;
an intelligent tuner operably connected to the powered prosthesis, wherein the intelligent tuner is configured to implement an intelligent computing algorithm for adjusting at least one of a plurality of impedance control parameters using a rule base, and wherein the rule base encodes human expert decision making using a plurality of rules that link changes in the measured gait parameters to corresponding adjustments to the impedance control parameters; and
a finite state machine operably connected to the powered prosthesis, wherein the finite state machine is configured to determine a gait cycle state based on the measured gait parameters and select a set of adjusted impedance control parameters based on the gait cycle state, wherein the impedance controller is configured to adjust the torque of the motor as a function of the measured gait parameters and the set of adjusted impedance control parameters.

US Pat. No. 10,335,293

DAMPING CONTROL METHOD FOR LOWER-LIMB PROSTHESES

PEKING UNIVERSITY, Shenz...

1. A damping control method for a lower-limb prosthesis, comprising the following steps:isolating a driving motor of the lower-limb prosthesis from a driving voltage, and operating the driving motor as a generator,
wherein the generator generates an alternating induced voltage from a joint rotation resulting from locomotion of a human body's CoM (Center of Mass), and where the method further comprises:
transforming the alternating induced voltage to a direct-current voltage with a full-bridge rectification circuit made of Schottky diodes or ideal diodes;
connecting output terminals of the full-bridge rectification circuit with a controlled switch to form a closed circuit, and generating induced current from the direct-current voltage; and
controlling the on-off ratio of the controlled switch with a Pulse-Width-Modulation (PWM) signal to generate a controllable motor current that results in a controllable braking torque under the magnetic field of the driving motor.

US Pat. No. 10,335,292

TORQUE MEASURING SPRING FOR A PROSTHETIC DEVICE

Bionx Medical Technologie...

1. An apparatus comprising:a first member;
a second member moveably connected to the first member;
a spring member fixed to the first member, the second member contacting the spring member during at least a portion of the movement of the second member with respect to the first member, the spring member deflecting from a neutral position when contacted by the second member and providing resistance to the rotation of the second member; and
a contact plate, attached to the spring member at the point of contact between the spring member and the second member.

US Pat. No. 10,335,290

EXPANDABLE INTERBODY FUSION DEVICE

SPINE WAVE, INC., Shelto...

1. An expansion member for use in an expandable interbody fusion device for implantation into the intradiscal space between opposing vertebral bodies in a spine, comprising:a unitary elongate body including a leading distal end, a trailing proximal end, and opposed lateral edges therebetween defining a maximum width, said body being sized and configured to move within an expandable interbody fusion device and to cause expansion of said device upon such movement, said body having a first beveled surface inclining in a first direction and extending across said maximum width from one lateral edge to the other, said first beveled surface defining a lifting surface, said body including a second beveled surface inclining in said first direction spaced proximally axially from said first beveled surface, said body including a locking surface and a bone filler facilitator selected from the group of facilitators consisting of tunnels, grooves and holes for receipt therein of a bone filler.

US Pat. No. 10,335,289

STAND ALONE INTERVERTEBRAL FUSION DEVICE

DePuy Synthes Products, I...

1. An intervertebral fusion device comprising:i) an intervertebral cage including;
a) upper and lower surfaces that are spaced from each other along a first direction and are configured to engage respective vertebral bodies;
b) a proximal wall that defines a proximal surface;
c) a distal wall opposite the proximal wall, and
d) first and second side walls connected between the proximal and distal walls, wherein the proximal surface defines a center that is equidistantly spaced from the first and second side walls; and
ii) a plate that defines a through-hole extending therethrough, wherein the plate is slidable along the proximal surface of the intervertebral cage along a direction of sliding that lies in a plane that is perpendicular to the first direction; and
iii) a screw received by the through-hole of the plate,
wherein the intervertebral cage defines a hole that extends into the proximal wall, and when the screw extends into the hole of the intervertebral cage, the plate is configured to be disposed in a position whereby 1) the through-hole of the plate is offset in its entirety from the center along the plane so as to define a gap between the through-hole and the center along the plane, 2) a first portion of the hole is aligned with the through-hole of the plate, and 3) a second portion of the hole is offset from the through-hole of the plate along the plane, the second portion of the hole being different than the first portion of the hole,
wherein the plane extends through both the through-hole of the plate and a central location of the hole of the intervertebral cage, the central location of the hole being centrally disposed in the hole with respect to the first direction.

US Pat. No. 10,335,288

SURGICAL IMPLANT SECURED BY PEGS AND ASSOCIATED METHODS

SpineSmith Partners, L.P....

1. An artificial disc comprising:an implantable device configured to be secured to two adjacent vertebrae, wherein the implantable device comprises:
an artificial disc that is insertable between a first vertebrae and a second vertebrae, and wherein said artificial disc comprises:
a first end plate comprising a concave inner surface;
a second end plate comprising a concave inner surface, the concave inner surface comprising a concave middle portion and a pair of concave outer portions disposed on opposite sides of the concave middle portion, wherein the pair of concave outer portions have a first curve that is different than a second curve of the concave middle portion; and
a bearing having an upper cylindrically-shaped convex surface and a lower convex surface, wherein the lower convex surface comprises a middle portion; and
wherein a first outer portion of the pair of concave outer portions is configured to be in contact with the bearing when the bearing translates within the concave inner surface of the second end plate in a first direction and a second outer portion of the pair of concave outer portions is configured to be in contact with the bearing when the bearing translates within the concave inner surface of the second end plate in a second direction that is opposite the first direction;
wherein the bearing is adapted to move relative to the first end plate and the second end plate and movement of the bearing relative to first end plate is independent of movement of the bearing relative to the second end plate; and
wherein an axis of the upper cylindrically-shaped convex surface and an axis of the lower convex surface are orthogonal to one another.

US Pat. No. 10,335,287

SPINAL FUSION IMPLANT AND RELATED METHODS

NuVasive, Inc., San Dieg...

1. An implant comprising:a body having a top surface and a bottom surface, a first sidewall and a second sidewall opposing one another, the first sidewall having a first length and the second side wall having a second length, and a first end and a second end, the first sidewall joining the upper surface at a first corner extending along a length of the body a first corner length and joining the bottom surface at a second corner extending along a length of the body a second corner length, the second sidewall joining the upper surface at a third corner extending along a length of the body a third corner length and joining the bottom surface at a fourth corner extending along a length of the body a fourth corner length, each of the first, second, third, and fourth corners being rounded, the second corner having a second corner radius that is constant along the second corner length and the third corner having a third corner radius that is constant along the third corner length, the first corner having a first corner radius that is variable along the first corner length and the fourth corner having a fourth corner radius that is variable along the fourth corner length, wherein the first corner length and the second corner length are equal to the first length of the first sidewall and the third corner length and the fourth corner length are equal to the second length of the second sidewall.

US Pat. No. 10,335,286

EXPANDABLE INTERSPINOUS PROCESS SPACER IMPLANT

DePuy Synthes Products, I...

1. A method of implanting an expandable spacer implant into a vertebral space defined between a superior vertebral body and an inferior vertebral body that are spaced from one another along a first direction, the method comprising:inserting the implant into the vertebral space in a collapsed configuration such that (i) an outer surface of a first housing of the implant engages one of the superior and inferior vertebral bodies, (ii) an outer surface of a second housing of the implant engages another of the superior and inferior vertebral bodies, (iii) inner surfaces of the first and second housings face one another and are spaced from the outer surfaces of the first and second housings along the first direction, (iv) the first and second housings extend from a proximal-most end of the implant to a distal-most end of the implant along a second direction, perpendicular to the first direction; and (v) a first pair of internal surfaces of the second housing are spaced from one another along the second direction and a second pair of internal surfaces of the second housing are spaced from one another along a third direction, perpendicular to the first and second directions, so as to at least partially define a void that extends into the inner surface of the second housing; and
expanding the implant by rotating a distracting member about an axis of rotation that extends along the second direction so as to move the distracting member within the void from a first position, wherein a first pair of opposed surfaces of the distracting member that define a first distance therebetween engage the first and second housings, to a second position, wherein a second pair of opposed surfaces of the distracting member that are angularly offset with respect to the first pair of opposed surfaces of the distracting member and define a second distance therebetween, greater than the first distance, engage the first and second housings so as to cause the first and second housings to move away from one another along the first direction, wherein the expanding step comprises causing a stabilizer to protrude beyond the outer surface of at least one of the first and second housings when the first and second housings are moved away from one another.

US Pat. No. 10,335,285

REVISEABLE STEMLESS PROSTHESES AND METHODS

Howmedica Osteonics Corp....

1. An orthopedic revision system comprising:a base member having a collar portion and at least one stabilization portion extending distally from the collar portion; and
a stem member having an attachment portion and a shaft portion,
wherein the stem member is configured to be received at least partially through an opening in the collar portion such that the attachment portion lies adjacent the collar portion and the shaft portion lies adjacent the at least one stabilizing portion.

US Pat. No. 10,335,284

TIBIAL IMPLANT HAVING AN ANATOMIC STEM

1. A tibial implant, comprising:a tray configured to abut a patient's bone; and
a stem extending distally from a surface of the tray and configured to extend longitudinally through a tibial intramedullary cavity of the patient's bone to a distal tip of the tibial implant, said stem having:
a proximal portion at a proximal level relative to the tray at which the stem has a proximal shape and a first center; and
a distal portion at a distal level relative to the tray at which the stem has a distal shape and a second center;
wherein the proximal shape and the distal shape comprise at least a first rounded corner, a second rounded corner, and a third rounded corner, the first and second rounded corners being adjoined by a first side, the second and third rounded corners being adjoined by a second side, and the third and first rounded corners separated by at least a third side;
wherein a first distance from the first center to the first rounded corner at the proximal level is greater than a second distance from the first center to the first side at the proximal level to provide anti-rotation contact between the first rounded corner at the proximal level and a bone near to which the first side at the proximal level is to be implanted; and
wherein, between at least the proximal portion and the distal portion of the stem, the second rounded corner shifts laterally relative to a longitudinal axis of the stem in a lateral direction away from the first center point.

US Pat. No. 10,335,283

REVERSE HIP SYSTEM AND METHOD

1. A reverse hip prosthesis comprising:an acetabular cup anchor portion configured for insertion into an acetabulum of a patient and fixation therein, the acetabular cup anchor portion including a convex surface for engagement with the patient's acetabulum and a concave surface opposite to the convex surface;
a plurality of first wearable inserts which are different from each other, and each of which may be selectively fixed to the acetabular cup anchor portion such that the first insert covers the concave surface of the acetabular cup anchor portion;
an acetabular stem having a first threaded end configured to be fixed to the acetabular cup anchor portion and/or the patient's acetabulum and a second threaded end extending in an opposite direction to the first threaded end;
an acetabular ball having a threaded recess therein which is attached to the second threaded end the acetabular stem;
a femoral stem configured for insertion into an intramedullary femoral canal of the patient;
a femoral cup attached to the femoral stem and having a concave surface which partially surrounds the acetabular ball; and
a second wearable insert which is fixed to the femoral cup and covers the concave surface of the femoral cup;
wherein the acetabular cup anchor portion is a largest size suitable for the patient's acetabulum, and the acetabular stem also functions as an artificial ligamentum teres.

US Pat. No. 10,335,282

MAGNETIC JOINT REPLACEMENT

Richard A. Rogachefsky, ...

1. A hip joint prosthesis, comprising:a femoral head comprising a plurality of magnets positioned on an anterior surface of the femoral head, the plurality of magnets comprising a first femoral magnet and a second femoral magnet, the first femoral magnet configured to provide a stronger magnetic field than the second femoral magnet;
an acetabular cup corresponding to the femoral head, the acetabular cup comprising a second plurality of magnets positioned on a posterior surface of the acetabular cup, the second plurality of magnets comprising a first acetabular cup magnet and a second acetabular cup magnet, the first acetabular cup magnet configured to provide a stronger magnetic field than the second acetabular cup magnet;
wherein the femoral head is configured to rotate within the acetabular cup through a range of motion corresponding to about 0-120 degrees of hip flexion, the first femoral magnet positioned on a medial side of the anterior surface of the femoral head and the first acetabular cup magnet positioned on a lateral side of the posterior surface of the acetabular cup such that the first femoral magnet and the first acetabular cup magnet align to form the strongest magnetic force between the first femoral magnet and the first acetabular cup magnet when the femoral head is in a position corresponding to about 90-120 degrees of hip flexion.

US Pat. No. 10,335,281

CARTILAGE MOSAIC COMPOSITIONS AND METHODS

ALLOSOURCE, Centennial, ...

1. A mosaic cartilage composition comprising:a 1 mm thick cartilage sheet comprising a plurality of interconnected cartilage tiles that are separated by channels formed in the cartilage sheet, each channel having a respective depth that is less than 1 mm, and wherein perforations are formed in the cartilage sheet beneath one or more of the channels; and
a cryopreservation medium.

US Pat. No. 10,335,280

METHOD FOR ABLATING TARGET TISSUE OF A PATIENT

Medtronic, Inc., Minneap...

1. A method for treating a human patient, the method comprising:emitting ultrasound energy from an ultrasound transducer positioned remotely from target tissue of the patient, wherein the ultrasound transducer is positioned at a desired location relative to the patient and target tissue using location and imaging techniques;
focusing the ultrasound energy such that one or more focal points are directed to the target tissue of the patient; and
ablating the target tissue at each focal point with the focused ultrasound energy without ablating non-target tissue through which the ultrasound energy passes between the ultrasound transducer and the one or more focal points.

US Pat. No. 10,335,279

METHOD AND DEVICE FOR TREATING DYSFUNCTIONAL CARDIAC TISSUE

BioVentrix, Inc., San Ra...

1. A patch for reducing a volume of a ventricle of a heart chamber comprising:a main body that is positionable about dysfunctional tissue of the ventricle, the main body comprising a woven fabric material; and
a deformable slit that extends upward from the main body, the deformable slit comprising a malleable metal material, the deformable slit having a shape of an elongated ellipse and forming a continuous, closed loop configured to allow the dysfunctional tissue to be pulled through the loop, wherein:
the woven fabric material extends continuously around the loop;
opposing walls of the deformable slit are configured to be displaced inwardly after the dysfunctional tissue is pulled through the loop to secure the patch about the dysfunctional tissue and reduce the volume of the ventricle; and
the opposing walls of the deformable slit comprise a more parallel configuration after the opposing walls are displaced inwardly.

US Pat. No. 10,335,278

PROSTHETIC HEART VALVE DEVICES, PROSTHETIC MITRAL VALVES AND ASSOCIATED SYSTEMS AND METHODS

Twelve, Inc., Menlo Park...

1. A prosthetic heart valve device for treating a valve of a human heart having a native annulus and native leaflets, comprising:a valve support having an upstream region and a downstream region with respect to a direction of blood flow;
a prosthetic valve within the valve support; and
an anchoring member having a connection structure and a fixation portion, the connection structure being attached to the valve support in an undeployed state and at least a portion of the connection structure extending laterally outward with respect to the valve support in a deployed state, the fixation portion having a plurality of interconnected struts that define an annular engagement surface and that are spaced laterally apart and outward from the valve support by the connection structure in the deployed state, wherein
at least a portion of the connection structure extends transverse with respect to the direction of blood flow,
the fixation portion extends upstream with respect to the connection structure and generally along the direction of blood flow, and
the annular engagement surface anchors the device to the native annulus.

US Pat. No. 10,335,277

ADJUSTABLE NOSECONE

BOSTON SCIENTIFIC SCIMED ...

1. A percutaneous valve delivery system, comprising:an outer sheath;
an inner catheter disposed within the outer sheath, the inner catheter including a plurality of non-concentric lumens formed therein;
a tubular extension extending distally from a distal end of the inner catheter;
wherein the tubular extension is axially movable relative to the inner catheter;
wherein the tubular extension is fixedly attached to and within a hypotube slidably received within one of the plurality of lumens;
a nose cone attached to the tubular extension;
a handle attached to the outer sheath, wherein the handle is configured to shift the outer sheath between a first position and a second position relative to the inner catheter; and
a valve replacement implant releasably coupled to the inner catheter.

US Pat. No. 10,335,276

TAVR VENTRICULAR CATHETER

1. A method of positioning an x-ray C-arm in coplanar alignment with an aortic valve, the method comprising:advancing a guide wire into a patient's aorta, across the patients aortic valve annulus, and into the patient's left ventricle cavity;
advancing an undeployed catheter along the guide wire into the patient's aorta, across the patient's aortic valve annulus, and into the patient's left ventricle cavity;
retracting the guide wire until the undeployed catheter deploys to form a deployed catheter, the deployed catheter comprising
a distal ring, the distal ring comprising a radiopaque outer surface and a plurality of openings for dispersing contrast medium; and
a substantially straight upper shaft connecting to the distal ring via a plurality of curves, the upper shaft disposed substantially perpendicularly to the distal ring, the distal ring, the upper shaft and the plurality of curves all formed unitarily from a resilient hollow tube;
retracting the deployed catheter until the deployed catheter contacts the patient's aortic valve on the ventricular side of the aortic valve and on opposite sides of the aortic valve annulus, the upper shaft extends through the aortic valve and the distal ring is beneath the leaflets of the aortic valve;
injecting radio opaque fluid into the deployed catheter to confirm catheter position; and
positioning the C-arm using images of the distal ring.

US Pat. No. 10,335,275

METHODS FOR DELIVERY OF HEART VALVE DEVICES USING INTRAVASCULAR ULTRASOUND IMAGING

MILLIPEDE, INC., Santa R...

24. A method of delivering an implant proximate a cardiac valve annulus, the method comprising:advancing a distal end of a delivery catheter proximate the cardiac valve annulus;
advancing the implant through the distal end of the delivery catheter proximate the cardiac valve annulus;
advancing a distal end of an ultrasound catheter proximate the cardiac valve annulus, the distal end of the ultrasound catheter including one or more ultrasonic transducers;
capturing an ultrasound image of the implant and the cardiac valve annulus with the one or more ultrasonic transducers; and
anchoring the implant to the cardiac valve annulus,
wherein the implant is a cardiac valve replacement and comprises:
a series of struts defining a tubular frame and an axis and forming a plurality of lower crowns;
a plurality of anchors coupled with the lower crowns of the frame and configured to translate axially relative to the frame to engage cardiac tissue proximate the cardiac valve annulus; and
a plurality of valve leaflets coupled with the frame.

US Pat. No. 10,335,274

ERGONOMIC MITRAL HEART VALVE HOLDERS

Edwards Lifesciences Corp...

1. A combination including a holder for handling and delivering a prosthetic mitral heart valve to an implantation site, comprising:a prosthetic mitral heart valve having an inflow end and three flexible commissure posts ending in tips projecting in an outflow direction;
a holder body contacting the inflow end of the heart valve, the holder body defining a central window aligned along an inflow-outflow axis through which leaflets of the heart valve are visible and having at least one peripherally-extending internal passage extending around the central window, wherein the holder body has relatively rotatable rings; and
three connecting sutures each fixed to the holder body and having a loop extending at least partly around the peripherally-extending internal passage, out of the holder body and along each of the commissure posts of the heart valve, the three loops of the connecting sutures mutually crossing over between the tips of the commissure posts, wherein each connecting suture has two free ends attached to different rotatable rings of the holder body, and wherein relative rotation of the rings applies tension to the connecting suture loops and causes the commissure post tips to move radially inward.

US Pat. No. 10,335,273

LEAFLET ENGAGEMENT ELEMENTS AND METHODS FOR USE THEREOF

BOSTON SCIENTIFIC SCIMED ...

1. An apparatus for endovascularly replacing a patient's heart valve, the apparatus comprising:an expandable anchor supporting a replacement valve disposed within a lumen of the expandable anchor; and
a delivery catheter defining a lumen, the delivery catheter being adapted to deliver the expandable anchor and replacement valve to a vicinity of the patient's heart valve within the lumen in a collapsed configuration;
wherein the expandable anchor and replacement valve are adapted for percutaneous delivery and deployment to replace the patient's heart valve;
wherein the expandable anchor comprises a plurality of closed cells forming a body portion of the expandable anchor and a proximal flange portion of the expandable anchor in a deployed configuration, the proximal flange portion extending radially outward from the body portion in the deployed configuration;
wherein closed cells forming the proximal flange portion are larger than closed cells forming the body portion, wherein the expandable anchor and the replacement valve are further adapted to permit blood flow through the replacement valve and to prevent blood backflow through the replacement valve after the replacement valve exits the delivery catheter and before the proximal flange portion exits the delivery catheter,
wherein an exterior surface of the expandable anchor is covered by a seal.

US Pat. No. 10,335,272

APPARATUS AND METHOD FOR REPAIRING THE FUNCTION OF A DISEASED VALVE

THE CLEVELAND CLINIC FOUN...

1. An apparatus for repairing the function of a diseased valve, the apparatus comprising:a tubular first support member expandable to a first average diameter and having oppositely disposed proximal and distal first support member ends;
a tubular second support member spaced axially apart from the first support member and expandable to a second average diameter that is smaller than the first average diameter, the second support member having oppositely disposed proximal and distal second support member ends; and
a tubular graft section interconnecting the first and second support members and defining an annulus axially spaced from both the first and second support members, the tubular graft section having oppositely disposed proximal and distal graft section ends axially spaced apart by a graft section body, the proximal graft section end being connected directly to the distal first support member end and the distal graft section end being connected directly to the proximal second support member end, a diameter of the tubular graft section at the proximal graft section end being larger than a diameter of the tubular graft section at the distal graft section end, the graft section overlapping and being secured to an outer surface of one of the first and second support members and the graft section underlying and being secured to an inner surface of the other of the first and second support members.

US Pat. No. 10,335,271

SYSTEMS FOR ASSESSING AND CUTTING PERICARDIAL TISSUE

Edwards Lifesciences Corp...

1. An assembly for assessing and cutting a leaflet of a prosthetic valve from a sheet of bioprosthetic tissue, the assembly comprising:a flat surface on which a sheet of bioprosthetic tissue may be supported;
a die for cutting the leaflet having a plate and a sharp die cutting pattern resembling the leaflet and defining a boundary, an exposed portion of the sharp die cutting pattern depending downward from the plate;
an opening formed in the die within the boundary of the die cutting pattern; and
a distance measurement gauge having a vertically movable probe that passes through the opening for measuring the thickness of the tissue, wherein the opening through the die permits passage of the vertically movable probe of the distance measurement gauge at different locations within the boundary of the die cutting pattern.

US Pat. No. 10,335,270

METHOD AND APPARATUS FOR COMPRESSING/LOADING STENT-VALVES

SYMETIS SA, Ecublens (CH...

1. An apparatus for compressing a transcatheter cardiac stent-valve, the apparatus comprising:a hollow channel having an interior surface shaped for progressively compressing the stent-valve in response to longitudinal advancement of the stent within the hollow channel, the hollow channel comprising at least one slot through a wall thereof; and
a mover comprising a portion fitting outside the circumferential periphery of the hollow channel and a portion slidable in the slot and projecting therethrough for engaging the stent-valve within the hollow channel, for applying to the stent-valve a longitudinal driving force from outside the hollow channel;
wherein the portion of the mover slidable in the slot is shaped as a blade having a thin leading edge or surface that advances within the slot, and a long edge or surface that slides against the edge of the slot.

US Pat. No. 10,335,269

SPEAKING VALVE HAVING A COVER PART FORMED AT LEAST PARTIALLY OF AN ELASTIC MATERIAL

1. A speaking valve for laryngectomy or tracheostomy care comprising: a cover part, a controller, a housing part and a filter, the housing having an upper edge at one end and forming a valve seat at an opposite end, the cover is mounted to the housing to overlap the upper edge of the housing wherein the controller has a closure part spaced apart from the cover part, the entire filter extending between the closure part and the cover part and wherein the closure part cooperates with the valve seat when the speaking valve is moved from an open position into a closed position, wherein the cover part is formed at least partially from an elastic material, wherein an at least partial deformation takes place at least in a region of the cover part when the speaking valve is moved from an open position into a closed position, and wherein the filter is arranged on the controller in such a way that the filter can follow the movement of the controller within the housing between the open position and the closed position.

US Pat. No. 10,335,268

ANTERIOR-POSTERIOR-CAPSULE-ACTUATED HYDRAULIC ACCOMMODATIVE INTRAOCULAR LENSES AND LENS SYSTEMS

1. A biocompatible accommodative hydraulic intraocular lens (AHIOL) system for implantation in the capsule of an eye from which the crystalline lens has been extracted via anterior capsule capsulorhexis, the system comprising:a self-reservoired hydraulic lens and an actuator for the hydraulic lens;
the actuator comprising a coaxial pair of cylinders having an outer cylinder and an inner cylinder in sliding relationship with one another, the outer cylinder comprising an inner ledge and an end configured for contact with one of an anterior and a posterior capsule, the inner cylinder comprising a plurality of substantially axis-parallel slots at one end and an end configured for contact with the other of the anterior and posterior capsule;
the hydraulic lens comprising a fixed focus lens in slideable relationship with respect to an inner actuator and further comprising a plurality of radial tabs at the inner cylinder slots and extending therethrough, an elastically reconfigurable transparent membrane one of fixedly affixed to the ledge and fixedly sandwiched between the ledge and a membrane ring, and a tensional bellows, one end of which is fixedly affixed to the fixed focus lens and the other end to the ledge,
wherein a closed hydraulic fluid chamber is defined by the transparent membrane, the tensional bellows, the fixed focus lens and the ledge, the fluid chamber containing a refractive hydraulic fluid having an index of refraction greater than that of aqueous humor.

US Pat. No. 10,335,267

INTRAOCULAR LENS HAVING PARTLY OVERLAPPING ADDITIONAL OPTICAL ACTIVE SECTORS ON OPPOSITE SIDES

OCULENTIS HOLDING B.V., ...

1. An intraocular lens (1) comprising an optic (3), the optic having first and second sides (3.1, 3.2) and comprising:a first main lens surface (4.1) at the first side (3.1) and a second main lens surface (4.2) at the second side (3.2), the first main lens surface providing a first main lens surface optical power and the second main lens surface providing a second main lens surface optical power,
the first and second main lens surfaces providing a main lens (4) having a main lens optical power to provide distance vision, and a main optical axis (R) defining a radial direction perpendicular to the main optical axis, a tangential direction around the main optical axis and an axial direction along the main optical axis;
a first additional optical active part (6) at the first side (3.1),
the first additional optical active part providing a positive relative optical power with respect to the first main lens surface optical power,
the first additional optical active part (6) being positioned at a distance from the optical axis (R) and in tangential directions being delimited by boundaries extending in radial directions, and
the first additional optical active part (6) overlapping with the second main lens surface (4.2) to form a secondary lens having the positive relative optical power of the first additional optical active part (6) with respect to the main lens (4) to provide near or reading vision;
a central part (8) at the first side (3.1),
the central part being arranged such that the main optical axis (R) passes through the central part, and fitting within a circumscribing circle around the optical axis,
the central part (8) being adjacent to the first additional optical active part (6), and
the central part having a relative optical power between ?2 and 2 diopter with respect to the first main lens surface optical power; and
a second additional optical active part (15) at the second side (3.2),
the second additional optical active part being arranged such that the main optical axis (R) passes through the second additional optical active part, and fitting within a circumscribing circle around the main optical axis (R), and
the second additional optical active part providing a relative optical power and/or an optical aberration with respect to the second main lens surface,
wherein the distance between the main optical axis (R) and the first additional optical active part (6) is smaller than the radius of the circle circumscribing the second additional optical active part (15), the diameter of the circle circumscribing the central part (8) being smaller than the diameter of the circle circumscribing the second additional optical active part (15), such that the second optical active part at least partly overlaps with the first additional optical active part (6) and partly overlaps with the first main lens surface (4.1).

US Pat. No. 10,335,265

RING ON A CLOSED WEB STENT-GRAFT FOR USE IN TIP CAPTURE

Medtronic Vascular, Inc.,...

1. A prosthesis for implantation within a body lumen, the prosthesis being configured for delivery via a catheter having a tip capture mechanism at a distal end thereof, the tip capture mechanism including at least a first tip capture finger and a second tip capture finger, the prosthesis comprising:a tubular graft of a graft material;
a stent coupled to the tubular graft and including a plurality of crowns and a plurality of struts with each crown being formed between a pair of opposing struts, the stent having endmost crowns that are adjacent to and distal of a proximal edge of the tubular graft, wherein the endmost crowns are secured to the graft material of the tubular graft; and
a ring that directly engages the endmost crowns of the stent, wherein the ring includes a plurality of integral sections that collectively form the ring and each integral section extends between two endmost crowns when the stent is in a compressed delivery configuration, and wherein each of a first integral section of the ring and a second integral section of the ring longitudinally extends beyond the proximal edge of the tubular graft as an attachment loop of the prosthesis that is configured to engage the first tip capture finger and the second tip capture finger, respectively, of the catheter when the stent is in the compressed delivery configuration, the first and second integral sections being disposed at opposing locations of the stent, and
wherein each of the first integral section of the ring and the second integral section of the ring do not longitudinally extend beyond the proximal edge of the tubular graft when the stent is in an expanded deployed configuration.

US Pat. No. 10,335,264

VASCULAR GRAFT

Byung Choo Moon, Toronto...

1. An artificial blood vessel, comprising:a cylindrical inner tube having a hollow part formed therein;
an outer tube provided at an outer circumferential surface of the inner tube and surrounding the inner tube so as to form a double tube structure with the inner tube; and
a connecting line formed in circumferential directions of the inner tube and the outer tube to connect the inner tube and the outer tube, wherein the inner tube includes at least a first guide line in an axial direction, and the outer tube includes at least a second guide line in an axial direction and is positioned at a position corresponding to a position of the first guide line.

US Pat. No. 10,335,263

ORGAN FOR TRANSPLANTATION AND ORGAN STRUCTURE

BIOS CO., LTD., Tokyo (J...

1. An organ structure wherein a kidney, a first ureter, a first urinary bladder, a second ureter, and a second urinary bladder are sequentially connected in this order, wherein the first ureter, the first urinary bladder, the second ureter, and the second urinary bladder are derived from an animal.

US Pat. No. 10,335,262

EMBOLIC PROTECTION DEVICES HAVING SHORT LANDING ZONES

Covidien LP, Mansfield, ...

1. An embolic protection device comprising:an elongate host element including a host element distal portion;
an embolic protection element being movable between a collapsed configuration and an expanded configuration, wherein the embolic protection element comprises;
at least one connecting arm having a first end and a second end,
an apposition ring connected to the second end of the at least one connecting arm, wherein when the embolic protection element is deployed in the expanded configuration, the apposition ring is configured to contact a luminal wall of a blood vessel of a patient in a manner that prevents passage of emboli between the embolic protection element and the luminal wall; and
a mesh connected to the apposition ring, wherein the mesh is dimensioned such that when the apposition ring is expanded to a maximum diameter, the mesh has a diameter at least 10 percent larger than the maximum diameter of the apposition ring; and
a flexible tether including a tether proximal end fixed to the host element distal portion and a tether distal end fixed to a proximal end of the embolic protection element, wherein the embolic protection element is connected to the elongate host element through the flexible tether so that the embolic protection device does not include a tip of a guidewire extending through the embolic protection element or distal to the embolic protection element, and wherein the flexible tether is configured to allow the elongate host element to move axially and laterally relative to the embolic protection element over a limited range of motion when the embolic protection element is deployed in the expanded configuration within the blood vessel.

US Pat. No. 10,335,261

VESSEL FILTER AND METHODS FOR USE

Sanford Health, Sioux Fa...

1. An apparatus comprising:a filter; and
a frame having a first end and a second end, wherein the frame includes a first support and a second support each continuously extending from the first end to the second end, wherein the first support is coupled to a first side of the filter and the second support is coupled to an opposite side of the filter, wherein the first support is directly coupled to the second support at the first end of the frame such that the frame and the filter taper to a first pointed tip at the first end of the frame, wherein the first support is directly coupled to the second support at the second end of the frame such that the frame and the filter taper to a second pointed tip at the second end of the frame, wherein the frame and the filter together define a first lumen, wherein the frame has shape memory and is movable between a first position in which the first lumen has a first diameter and a second position in which the first lumen has a second diameter, wherein in the second position, the first support and the second support are arranged spaced apart such that there is a gap between the first support and the second support, wherein the first diameter is smaller than the second diameter, wherein the frame and filter together are configured such that an entire length of the apparatus from the first end of the frame to the second end of the frame is configured to be circumferential to a second lumen of a target vessel in the second position, wherein an entire length of the first lumen defined by the frame and the filter is configured to be substantially concentric with the second lumen of the target vessel in the second position, and wherein the frame has an intermediate position such that the frame and the filter define a cone-shape at the second end of the frame such that the first lumen has the first diameter at the second end of the frame and the first lumen has the second diameter at the first end of the frame when the frame transitions from the second position to the first position.

US Pat. No. 10,335,260

METHODS OF TREATING A THROMBUS IN A VEIN USING CYCLICAL ASPIRATION PATTERNS

Insera Therapeutics, Inc....

1. A method of treating a thrombus in a vein using a repetitive cyclical pattern for aspiration, the method comprising:inserting a distal end of a catheter into the vein, wherein the thrombus is distal to the distal end of the catheter, wherein the thrombus causes acute ischemic stroke due to cerebral venous sinus thrombosis or causes deep vein thrombosis;
choosing the cyclical pattern from a plurality of provided cyclical patterns, the cyclical pattern comprising repetition of a first suction level, a second suction level different than the first suction level, and a third suction level different than the first suction level and the second suction level; and
aspirating the thrombus using negative pressure through the catheter, the negative pressure varying according to the chosen cyclical pattern generated by power electronics of an automated negative suction device.

US Pat. No. 10,335,259

3D FILTER FOR PREVENTION OF STROKE

FRID MIND TECHNOLOGIES, ...

1. An implantable endoluminal prosthesis comprising: a braided framework defining a cylindrical lumen devoid of impermeable membrane, said braided framework being self-expandable, comprising a plurality of layers of wires made of biocompatible material, each layer forming a mesh, the meshes forming a lattice with a plurality of wires of given layers, the lattice defining polygonal opening units when observed normal to a wall of the implantable endoluminal prosthesis, a diameter (?25) of the wires being at least 30 ?m and at most 150 ?m, a mean diameter (?27) of an inscribed circle of the polygonal opening units being at least 75 ?m and at most 200 ?m in a fully expanded state, characterized in that:the braided framework consists of at least 128 and at most 512 wires;
a ratio (T1?25) of a thickness (T1) of a wall of said implantable endoluminal prosthesis to the diameter (?25) of wire is at least 3.0;
in the fully expanded state, a surface coverage ratio (SCR) of said braided framework is more than 50% and less than 90%;
when the implantable endoluminal prosthesis is deployed in a curved lumen having a H/W ratio between 0.5 and 0.9, the mean diameter (?27) of the inscribed circle of opening units is at least 75 ?m and at most 200 ?m, a length-related compression ratio (LCR) being between 15% and 40%, and the surface coverage ratio (SCR) of the braided framework being more than 50% at a side of outer curve.

US Pat. No. 10,335,257

THREE-DIMENSIONAL RESORBABLE IMPLANTS FOR TISSUE REINFORCEMENT AND HERNIA REPAIR

Tepha, Inc., Lexington, ...

1. A reinforced absorbable implant comprising:a) a three-dimensional structure comprising an original three dimensional shape comprising a concave and a convex surface configured to contour to a patient's tissue, and monofilament, multifilament fibers or combinations thereof comprising poly-4-hydroxybutyrate (P4HB) or a copolymer thereof, or a porous film comprising P4HB or a copolymer thereof, and
b) a reinforcing material comprising a continuous or interrupted ring of P4HB extrudate at the outlying border of the three-dimensional structure, wherein the implant can be temporarily deformed for implantation and the three dimensional structure unaided assumes its original three-dimensional shape,
wherein the implant has one or more of the following properties:
(i) a suture pullout strength of at least 10 N
(ii) a burst strength of at least 1 Kg;
(iii) pore diameters of at least 50 ?m; and
(iv) a Taber stiffness that is less than 100 Taber stiffness units.

US Pat. No. 10,335,256

SURGICAL ARTICLES AND METHODS FOR TREATING PELVIC CONDITIONS

Boston Scientific Scimed,...

1. A method of supporting a tissue of a pelvic floor, the method comprising:creating an incision that allows access to a region of the pelvic floor;
providing a pelvic implant including a tissue support portion, a first extension portion, and a second extension portion, the tissue support portion including a first side end and a second side end opposite the first side end, the first side end having a first length and the second side end having a second length, the second length being different than the first length, the first extension portion and the second extension portion being integrally formed with the tissue support portion, a first anchor disposed at the first extension portion and a second anchor disposed at the second extension portion, a third length between the first extension portion and the second extension portion defining a third side end, the third side end being at an angle with respect to at least one of the first side end or the second side end, the pelvic implant having a width at a medial portion of the tissue support portion, the third length being larger than the width;
adjusting a length of the first extension portion to allow a distal end of the first anchor to reach a desired tissue within or external to the pelvic floor;
passing the pelvic implant through the incision and placing the tissue support portion at the tissue of the pelvic floor; and
positioning the tissue support portion at the region of the pelvic floor to support the tissue of the pelvic floor.

US Pat. No. 10,335,255

STRAW FOR THE PRESERVATION OF A PREDETERMINED DOSE OF LIQUID-BASED SUBSTANCE, IN PARTICULAR A BIOLOGICAL SUBSTANCE

IMV TECHNOLOGIES, Saint ...

1. A straw for preservation of a predetermined dose of liquid-based substance containing water, comprising a tube configured to be filled with the liquid-based substance, the liquid-based substance being a biological substance, the tube extending between a first end and a second end and further comprising a liquid-tight, gas-permeable stopper, the stopper being disposed in the tube close to a first end of the tube and extending between a first end turned towards the first end of the tube and a second end turned towards the second end of the tube, said stopper and said tube being configured so that after the liquid-based substance has come to meet the stopper by the second end of the stopper, the stopper blocks passage of the liquid-based substance and, by pushing on the first end of the stopper, the stopper is slidable in the tube towards the second end of the tube;wherein the stopper comprises towards the second end of the tube a barrier plug formed over the whole cross-section of the tube by hydrophobic threads, the barrier plug being configured to allow the liquid-based biological substance to pass therethrough while filling the tube but to be repelled by the barrier plug while passage of the liquid-based substance is blocked by the stopper.

US Pat. No. 10,335,254

METHOD AND APPARATUS FOR RECORDING SPATIAL GINGIVAL SOFT TISSUE RELATIONSHIP TO IMPLANT PLACEMENT WITHIN ALVEOLAR BONE FOR IMMEDIATE-IMPLANT PLACEMENT

EVOLLUTION IP HOLDINGS IN...

1. A soft tissue preservation arrangement, comprising:a hollow shell with an interior volume and a shell axis, the hollow shell having an outer surface configured to engage a soft tissue socket after a tooth has been extracted from a bone socket, the shell having a first perimeter configured for placement toward the bone socket and a second perimeter configured for placement adjacent an outer surface of the soft tissue socket, the first perimeter being smaller than the second perimeter so that the shell tapers outwardly from the first perimeter to the second perimeter, the second perimeter having an asymmetrically scalloped shape; and
a temporary post having a maximum dimension that is less than a minimum dimension of the hollow shell such that when the temporary post extends in the interior volume of the hollow shell such that an interior space is formed between an outer surface of the temporary post an inner surface of the hollow shell,
wherein the minimum inside diameter of the first perimeter of the hollow shell is greater than the maximum outside diameter of the temporary post, whereby the hollow shell and the temporary post do not make physical contact during axial relative movement of the hollow shell and temporary post, wherein the temporary post has an upper end portion and a lower end portion, wherein the lower end portion is configured to engage with a dental implant such that the first outer perimeter is situated above the lower end portion.

US Pat. No. 10,335,253

TOOTH-POSITIONING APPLIANCE FOR CLOSING SPACES

Martz Inc., Bakersfield,...

1. A tooth-positioning appliance comprising:a first appliance segment having:
a shell with at least one recess for removably engaging a first tooth; and
a receptacle on the shell of the first appliance segment;
a second appliance segment having:
a shell with at least one recess for removably engaging a second tooth, wherein the first tooth and the second tooth are separated by a space; and
a tab extending laterally from the second appliance segment spanning the space and in sliding engagement with the receptacle of the first appliance segment, the shell of the second appliance segment and the tab of the second appliance segment being a single piece of material; and
an activating element connected between the first appliance segment and the second appliance segment exerting a force to change the space as the tab slides with respect to the receptacle.

US Pat. No. 10,335,252

SYSTEM AND METHOD FOR DIGITAL TOOTH IMAGING

Align Technology, Inc., ...

1. A method for combining digital data from at least first and second scanned impressions of a jaw of a patient to form a combined digital jaw impression of the jaw for use in a customized dental treatment of the patient, the method comprising:receiving a first scanned impression of one jaw of the patient, the first scanned impression having distorted digital tooth data for a first tooth of the patient;
receiving a second scanned impression of the one jaw of the patient, the second scanned impression having non-distorted digital tooth data for the first tooth of the patient, wherein the first scanned impression and the second scanned impression are scanned impressions of the same jaw of the patient; and
creating a combined digital jaw impression by replacing the distorted digital tooth data for the first tooth of the first scanned impression with the non-distorted digital tooth data for the first tooth from the second scanned impression.

US Pat. No. 10,335,251

ORTHODONTIC DIGITAL SETUPS

3M INNOVATIVE PROPERTIES ...

1. A computer-implemented method of simulating a collision between a first virtual tooth and a second virtual tooth comprising:receiving into the computer digital data defining, in three-dimensional space, the first virtual tooth and the second virtual tooth;
receiving permissible movement input data directed to permissible movement of the first virtual tooth along or about a first axis;
using the computer's processor, simulating, in three-dimensional space, bringing the first virtual tooth into contact with the second virtual tooth while constraining movement of the first virtual tooth based on the permissible movement input data, further comprising accompanying the movement of the first virtual tooth with an automatic movement that forces the first virtual tooth along or about an axis different from the first axis until the first virtual tooth contacts one or more neighboring teeth; and
displaying, in a user interface of a display, data resulting from the simulation.

US Pat. No. 10,335,250

THREE-DIMENSIONAL PRINTED DENTAL APPLIANCES USING LATTICES

uLab Systems, Inc., Redw...

1. A method for fabricating an oral appliance, comprising:capturing a three-dimensional representation of a dentition of a subject;
generating a free-form structure having a polymeric lattice structure via three-dimensional printing, wherein the lattice structure is based on the three-dimensional representation and is complementary to at least part of a surface of the dentition, wherein the lattice structure defines a plurality of open spaces such that the free-form structure is at least partially transparent; and
manufacturing the lattice structure by impregnating or covering a coating into or upon the lattice structure such that the oral appliance is formed.

US Pat. No. 10,335,249

SYRINGE FOR MULTI-COMPONENT MATERIALS, METHOD OF ACTIVATING A SYRINGE, MIXING AND DISPENSING APPARATUS AND MULTI-COMPONENT CARTRIDGE

SULZER MIXPAC AG, Haag (...

1. A single fill syringe for multi-component materials, comprising:a mixer housing;
a mixing element;
a multi-component cartridge; and
a mixing head separate from the mixer housing, the mixing head being arranged at least partly within the mixer housing and adjacent to the multi-component cartridge, and arranged to be moveable in an axial direction of the syringe between at least two positions, the at least two positions comprising a sealed position and a dispensing position, the movement in the axial direction of the mixing head being brought about by a rotation of at least a part of the mixer housing relative to the multi-component cartridge, and the mixing head being axially displaced in a direction opposite to a dispensing direction on displacement of the mixing head from the sealed position into the dispensing position, the syringe configured to be activated upon displacement of the mixing head from the sealed position to the dispensing position by the rotation of the at least a part of the mixer housing relative to the multi-component cartridge and with at least a part of a base of the mixing head being a seal and being configured to seal outlets of the multi-component cartridge when the mixing head is in the sealed position, rotation of the mixer housing causing axial displacement of at least a part of the mixer housing and the mixing head relative to the multi-component cartridge.

US Pat. No. 10,335,248

THERAPEUTIC TOOTH BUD ABLATION

TRIAGENICS, INC., Eugene...

19. A tooth bud ablation procedure that results in tooth agenesis, comprising the steps of:(a) obtaining a volume scan image in which hard tissue is visible;
(b) obtaining a volume scan image in which a dental impression is visible;
(c) superimposing the volume scan image of the hard tissue with the volume scan image of the dental impression to create an overlay so that soft tissue is “visible” as the space between the visible hard tissue and the visible dental impression;
(d) pre-operatively taking measurements from said overlay in which said soft tissue is “visible” to determine a three-dimensional location of a measured middle of a tooth bud;
(e) placing an ablation probe tip having a center of ablation so that said center of ablation is in said three-dimensional location of the measured middle of a tooth bud; and
(f) at least partially ablating at least one tooth bud.

US Pat. No. 10,335,245

PACKAGING, PACKAGING ASSEMBLY, AND METHOD FOR USING THE SAME

OSSUR ICELAND EHF, Reykj...

18. A packaging assembly containing an article comprising at least first and second functional features and secured at a predetermined location relative to the packaging assembly in closed and open configurations of the packaging assembly, the packaging assembly comprising:at least two sections arranged to be secured in place relative to one another in the closed configuration, and move relative to one another in the open configuration, the at least two sections forming an inner surface defining an attachment area upon which the article is secured;
at least one instruction area located along the inner surface and having indicia comprising at least first and second indicators pointing to the at least first and second functional features of the article, respectively, for placement in the packaging assembly, the at least one instruction area being located relative to an attachment area displayed by the at least two sections and the article having a feature corresponding to and secured to the attachment area at a marking in both the closed and open configurations;
at least one closure is arranged to secure edges of the at least two sections to one another in the closed configuration;
wherein the indicia represents a sequence of steps for utilizing a sequence of the at least first and second functional features of the article;
wherein the article is secured to the at least two sections such that the article is stabilized in the open configuration of the packaging assembly in an open configuration of the article;
wherein the packaging assembly is arranged to support the article in a preconfigured condition for donning.

US Pat. No. 10,335,244

MOBILE MEDICAL CART

NEONATAL PRODUCT GROUP, I...

1. A medical cart for transporting medical supplies, the cart comprising:a chassis having a plurality of wheels attached thereto;
a plurality of drawers supported on the chassis, wherein at least one of the drawers is slidable along a first axis toward the chassis to a closed orientation and slidable away from the chassis along the first axis to an open configuration, and wherein at least one of the drawers has a drawer lock shiftable between a locked position in which it secures the drawer in the closed orientation and an unlocked position in which it allows the drawer to be in the open configuration;
a plurality of drawer mounts disposed on interior surfaces of the chassis;
a plurality of interchangeable drawer slides attached to the plurality of drawers and removably attachable to the plurality of drawer mounts so that the drawer slides may be placed on different mounts thereby allowing different-sized drawers to be mounted to the chassis; and
a temperature-regulated compartment mounted within the chassis, the temperature-regulated compartment having a storage space with a door, a lock shiftable between a locked position in which it prevents the door from opening and an unlocked position in which it allows the door to open, and a temperature-regulating unit that regulates a temperature of the storage space at a predetermined temperature.

US Pat. No. 10,335,243

DRAPE UNIT

OLYMPUS CORPORATION, Tok...

1. A manipulator system comprising:a manipulator having:
an elongated portion;
a proximal portion coupled to a proximal end of the elongated portion; and
an end effector coupled to a distal end of the elongated portion;
a console detachably coupled to the manipulator, the console having a motor configured to generate a driving force so as to drive the end effector;
a drape configured to separate the manipulator and the console, the drape having:
a main body configured to cover a top surface of the console, the main body having an opening so as to expose a connecting portion; and
an adapter detachably coupled to a top surface of the motor, the adapter being configured to cover the opening;
wherein the motor is detachably coupled to the proximal portion via the adapter, and the adapter is configured to transmit the driving force from the motor to the proximal portion;
the console further having a linear-motion mechanism configured to move the motor in a horizontal direction relative to the console; and
the adapter is configured to be movable relative to the main body in response to a movement of the motor.

US Pat. No. 10,335,242

INDICATOR FOR TOOL STATE AND COMMUNICATION IN MULTI-ARM ROBOTIC TELESURGERY

Intuitive Surgical Operat...

1. A method comprising:receiving an input at a control system indicating a status change for a first tool coupled to a first manipulator assembly of a telesurgical system, wherein the status change is correlated to a procedure to decouple the first tool from the first manipulator assembly or manually reconfigure the first manipulator assembly;
transmitting a command to the first manipulator assembly; and
responsive to the transmitted command, activating a multiple-color light emitting diode (LED) array in an indicator section on the first manipulator assembly to generate a signal indicating a reconfiguration action for the first tool or the first manipulator assembly to a first user.

US Pat. No. 10,335,241

METHOD AND APPARATUS FOR INTRAOPERATIVE MEASUREMENTS OF ANATOMICAL ORIENTATION

DePuy Synthes Products, I...

1. An apparatus comprising:a plurality of electronic devices, each electronic device including an internal power source and being configured to detect at least one of an orientation or a position of the electronic device with respect to earth's frame of reference in a plurality of dimensions; and
a coupler configured to removeably maintain the plurality of electronic devices in physical proximity of one another, the coupler maintaining the plurality of electronic devices in at least one of a similar orientation or a similar position;
wherein the internal power source of the electronic device is configured to be deactivated when at least a portion of the coupler is in proximity to the electronic device.

US Pat. No. 10,335,240

ENDOVASCULAR NAVIGATION SYSTEM AND METHOD

ARROW INTERNATIONAL, INC....

1. An endovascular navigation system, comprising:an elongate flexible member configured to access the venous vasculature of a patient;
a sensor disposed at a distal end of the elongate flexible member and configured to sense a physiological signal of the venous vasculature of the patient;
a processor configured to:
receive the physiological signal of the venous vasculature of the patient provided by the sensor;
process the physiological signal to determine one or more physiological characteristics of the venous vasculature of the patient;
track a position of the distal end of the elongate flexible member within the venous vasculature of the patient over time; and
determine, based on the one or more physiological characteristics of the venous vasculature of the patient, that the position of the distal end of the elongate flexible member is within a predetermined structure within the venous vasculature of the patient;
a display output device configured to simultaneously display:
a graphical representation of a path between tracked positions of the distal end of the elongate flexible member within the venous vasculature of the patient over time;
a first visual indication of the position of the distal end of the elongate flexible member in real time;
at least part of the physiological signal provided by the sensor over time; and
a second visual indication that the distal end of the elongate flexible member is within the predetermined structure within the venous vasculature of the patient only when it is determined that the position of the distal end of the elongate flexible member is within the predetermined structure within the venous vasculature of the patient, wherein the second visual indication is different from the physiological characteristic of the venous vasculature of the patient, and the graphical representation is different from the at least part of the physiological signal and the second visual indication; and
an audible output device configured to output an audible indication of the position of the distal end of the elongate flexible member.

US Pat. No. 10,335,239

DISPOSABLE REFLECTIVE MARKER

Brainlab AG, Munich (DE)...

1. A marker for optical medical navigation, the marker comprising a structure with one or more recesses, and one or more supporting elements, wherein the one or more supporting elements are accommodated within the one or more recesses and support one or more optically detectable elements wherein the one or more recesses have a first opening which allows the one or more optically detectable elements together with one of the one or more supporting elements to be introduced into one of the one or mote recesses, and wherein:the one or more recesses each have at least two second openings which are different from the first opening, wherein each of the at least two second openings has a predetermined contour and allows one of the one or more optically detectable elements to be optically detected therethrough, wherein the structure and the one or more supporting elements retain the at least one of the one or more optically detectable element within one of the one or more recess, and wherein a detectable shape of the one or more optically detectable elements is confined by the predetermined contours of the at least two second openings.

US Pat. No. 10,335,237

VISUAL ORIENTATION AID FOR MEDICAL INSTRUMENTS

Brainlab AG, Munich (DE)...

1. A method comprising:displaying, on an image output of a medical navigation system, a virtual representation of a medical instrument in a positional relationship to a part of a patient's body, the virtual representation of the medical instrument having an axis and a tip; and
displaying, on the image output of the medical navigation system, an orientation aid situated at the tip of the virtual representation of the medical instrument, the orientation aid shaped as a cone having a symmetry axis coinciding with the axis of the visual representation of the medical instrument and a particular aperture angle based on a desired orientation of the medical instrument relative to a predefined axis of the part of the patient's body, the particular aperture angle of the cone determining an exterior enveloping straight line of the cone, the exterior enveloping straight line of the cone abutting the predefined axis of the part of the patient's body indicating that the medical instrument has the desired orientation.

US Pat. No. 10,335,236

SURGICAL SYSTEM USING A REGISTRATION DEVICE

1. A method comprising:determining, pre-operatively, a patient-specific coordinate system for a portion of a patient's anatomy to be operated on, where the patient-specific coordinate system defines at least one of
an anterior pelvic (AP) plane, or
an ipsilateral hemipelvic plane;
registering, during an operating phase, the portion of the patient's anatomy to be operated on to the pre-operatively determined patient-specific coordinate system, the registering performed using a physical instrument or a virtual instrument;
continuously tracking, by a processor, positions of a robotic controlled instrument relative to the patient-specific coordinate system as the robotic controlled instrument moves near the portion of the patient's anatomy, wherein the continuously tracking includes receiving position information from a tracking system utilizing a tracker attached to the robotic controlled instrument as the robotic controlled instrument moves;
automatically engaging and disengaging operation of the robotic controlled instrument based on the continuously tracked positions relative to the patient-specific coordinate system; and
utilizing the patient-specific coordinate system to at least one of
orient, or
locate
an implant at the portion of the patient's anatomy.

US Pat. No. 10,335,234

ABLATION CANNULA AND KIT WITH INSERT

ORTHOPAEDIC DEVELOPMENT, ...

1. An ablation tool comprising:a trocar;
a cannula comprising a hollow shaft, the hollow shaft of the cannula having a proximal segment and a distal segment, wherein the distal segment comprises a distal tip aligned with the hollow shaft of the cannula to permit passage of the trocar within the hollow shaft of the cannula, and having tissue-adhering irregular surfaces protruding therefrom;
an auxiliary port extending from an exterior surface of the cannula and defining a hollow passageway into the hollow shaft of the cannula; and,
an insert comprising an additional hollow shaft and adapted to be inserted into the hollow shaft of the cannula, the insert further comprising an auxiliary port extending from an exterior surface of the insert and defining a hollow passageway into the additional hollow shaft of the insert, the additional hollow shaft comprising an outside diameter of less than an interior diameter of the hollow shaft of the cannula so as to permit passage of a laser fiber through the additional hollow shaft of the insert.

US Pat. No. 10,335,233

MYOMA/POLYP IN-OFFICE TREATMENT WITH LASERS

Biolitec Unternehmensbete...

1. A method for the laser treatment of uterine growths without the use of general or regional anesthetic consisting of the steps of:a. providing a paracervical anesthetic to a cervix;
b. inserting a hysteroscope into a uterus;
c. assessing size, location and type of unwanted uterine growth;
d. placing a distal end of said hysteroscope to a position proximate to said uterine growth;
e. inserting an optical waveguide, whose proximal end is connected to a radiation source and whose distal end comprises a radiation distribution device, into said hysteroscope, wherein said radiation distribution device comprises a needle-like fiber;
f. advancing said distal end of said waveguide through said distal end of said hysteroscope to a predetermined point inside said uterine growth;
g. irradiating said uterine growth with radiation from said radiation source so as to cut/vaporize said growth to cause reduction to a size/shape for easy mechanical removal or elimination by vaporization of said uterine growth, while not impairing a patient's fertility;
h. assessing results by ultrasound imaging; and,
i. repeating steps g. and h. until unwanted growth is removed.

US Pat. No. 10,335,232

APPARATUS FOR USING INTENSE PULSED LIGHT TO NON-INVASIVELY TREAT BLEPHARITIS, DRYEYE, CONJUNCTIVAL BLOOD VESSELS, PIGMENTED LESIONS, AND OTHER PROBLEMS OF THE EYE AND EYELID

1. An IPL system for precisely and non-invasively treating small blood vessels, small lesions, small dermatological stains, ingrown hairs, blepharitis, dry eye, and other ocular and periocular problems of a patient, including:a handpiece;
a power source;
an IPL source, including a crystal having a distal end and a handpiece end operatively connected to the handpiece;
controls for varying one or more parameters that determine the amount of IPL to be used;
wherein the handpiece is sized and configured for precise digital manipulation by an operator's fingers for applying IPL to non-corneal and periocular portions of an eye and is operatively connected to the power source, the IPL source, and the controls;
a distance guide, sized and configured to contact the non-corneal and periocular portions of the eye, and having a distal end for contact and a proximal end attached to the handpiece such that the distal end of the IPL source is located at a fixed and known distance from the distal end of the distance guide; and
an eye shield for covering a portion of the patient's eye, including the entire cornea.

US Pat. No. 10,335,231

MICROWAVE APPLICATOR AND METHOD OF FORMING A MICROWAVE APPLICATOR

EMBLATION LIMITED, Alloa...

1. A method of forming a medical microwave applicator for use in treating tissue comprising:forming a body comprising dielectric material so that there is a void in the dielectric material;
performing a deposition process to deposit conductive material in the void to partially or entirely fill the void to create a conductive feature that adheres directly to the dielectric material, the deposited directly adhered conductive feature being a probe feed that partially or entirely fills the void and that couples electromagnetic energy via the directly adhered conductive material of the probe feed into a waveguide comprising the dielectric material such that the electromagnetic energy is transmitted through the dielectric material of the waveguide to an end of the medical microwave applicator for placing adjacent to or in contact with the tissue;
further performing the deposition process so that the directly adhered conductive material of the probe feed is deposited to have a thickness and configuration to provide a directly adhered transmission structure that receives the electromagnetic energy from a coaxial feed and transmits the electromagnetic energy through the directly adhered conductive material of the probe feed and into the dielectric material; and
forming a conductive link from the conductive material deposited in the void to conductive material on an outer surface, the outer surface of the conductive material being configured for connection to the coaxial feed to receive the electromagnetic energy via the coaxial feed and the conductive link being arranged so as to launch the electromagnetic energy as a transverse electric (TE) mode.

US Pat. No. 10,335,229

VESSEL SEALING INSTRUMENT WITH SUCTION SYSTEM

COVIDIEN LP, Mansfield, ...

1. A forceps, comprising:a first elongated shaft having a first proximal portion and a first distal portion;
a second elongated shaft having a second proximal portion and a second distal portion;
a first jaw member secured to and extending from the first distal portion;
a second jaw member secured to and extending from the second distal portion, the first and second jaw members moveable about a pivot between an open position in which the first and second jaw members are spaced-apart from one another and a closed position in which the first and second jaw members cooperate to grasp tissue therebetween; and
a tube extending from the first proximal portion to the first distal portion and including a distal tube segment, the distal tube segment slidable relative to the first and second jaw members between a retracted position relative to the first and second jaw members and a deployed position relative to the first and second jaw members distal of the retracted position.

US Pat. No. 10,335,228

SURGICAL INSTRUMENT WITH SWITCH ACTIVATION CONTROL

COVIDIEN LP, Mansfield, ...

1. An electrosurgical instrument, comprising:a housing;
an elongated shaft extending from the housing;
a pair of opposing jaw members disposed at a distal portion of the elongated shaft and configured to connect to a source of electrosurgical energy, at least one of the jaw members movable relative to the other jaw member between an open position and a closed position;
a movable handle operably coupled to the housing and configured to move between an unactuated position and an actuated position to move at least one of the jaw members between the open and closed positions;
a switch supported by the housing and configured to move between an activated position and a deactivated position to control delivery of electrosurgical energy to the jaw members;
a depressible button having a proximal portion coupled to the switch and a distal portion extending from the housing, the distal portion of the depressible button configured to be engaged by the movable handle to move the switch between the activated and deactivated positions;
a switch activation post housed within the depressible button, the switch activation post extending from the distal portion of the depressible button and configured to engage the switch to move the switch to the activated position upon depression of the depressible button; and
a coiled spring disposed around the switch activation post and housed within the depressible button, the coiled spring configured to maintain a spring force on the switch to maintain the switch in the activated position during at least a portion of travel of the moveable handle toward the unactuated position.

US Pat. No. 10,335,227

ELECTROSURGICAL TISSUE SEALER AND CUTTER

COVIDIEN LP, Mansfield, ...

1. A surgical instrument, comprising:an end effector including a pair of jaw members having opposing tissue clamping surfaces, at least one of the jaw members configured to move with respect to the other jaw member from an open configuration for receiving tissue and a closed configuration for clamping tissue between the opposing tissue clamping surfaces, at least one jaw member defining an elongated cam slot;
a reciprocating member advanceable through a plurality of sequential sealing positions through the elongated cam slot to a distal end thereof to cam the pair of jaw members to the closed configuration, wherein advancement of the reciprocating member is configured to be interrupted at each of the plurality of sequential sealing positions, wherein the reciprocating member includes a blade for transecting tissue and a cam driver configured to engage the elongated cam slot and the blade is disposed proximal of the cam driver; and
a plurality of electrically isolated and independently activatable electrodes supported by at least one of the tissue clamping surfaces of one of the pair of jaw members, each of the plurality of electrically insulated electrodes spaced along at least one respective tissue clamping surface and configured to selectively deliver electrosurgical energy to tissue, wherein the blade is disposed sufficiently proximal relative to the cam driver such that when the reciprocating member is in each of the plurality of sequential sealing positions, the blade is disposed proximal one of the electrically isolated electrodes of the plurality of electrically insulated electrodes.

US Pat. No. 10,335,226

SURGICAL FORCEPS CAPABLE OF ADJUSTING SEALING PRESSURE BASED ON VESSEL SIZE

COVIDIEN LP, Mansfield, ...

1. A forceps, comprising:an end effector assembly including first and second jaw members disposed in opposing relation relative to one another, at least one of the first and second jaw members movable relative to the other from a first position to a plurality of second positions, the first and second jaw members configured to grasp tissue therebetween in each of the plurality of second positions, at least one of the first and second jaw members including a sensor configured to sense at least one property of tissue disposed between the first and second jaw members and determine an output based upon the at least one sensed property;
a handle assembly including a movable handle coupled to the end effector assembly, the movable handle movable between an initial position and a plurality of subsequent positions for moving the first and second jaw members between the first position and the plurality of second positions, respectively;
a processor configured to receive the output from the sensor and determine a seal pressure for adequately sealing tissue disposed between the first and second jaw members based upon the output; and
a regulator in communication with the processor and configured to receive the determined seal pressure from the processor, the regulator configured, based on the determined seal pressure received, to regulate a range of motion of the first and second jaw members between the first position and a selected one of the plurality of second positions such that movement of the first and second jaw members from the first position to the selected one of the plurality of second positions applies the determined seal pressure to tissue disposed between the first and second jaw members, the regulator disposed within the handle assembly and configured to regulate the range of motion of the first and second jaw members by limiting movement of the movable handle between the initial position and a selected one of the subsequent positions to thereby regulate the range of motion of the first and second jaw members.

US Pat. No. 10,335,225

ELECTROSURGICAL MEDICAL DEVICE HANDPIECE WITH INSULATED ASPIRATION SYSTEM

Arthrex, Inc., Naples, F...

1. An electrosurgical instrument for the treatment of tissue, comprising:a shaft;
an electrode assembly, comprising:
at least one active electrode;
at least one return electrode separated from the active electrode via at least one insulator;
the at least one insulator forming an internal aspiration collection chamber configured to received aspirated material from a surgical site and to pass the aspirated material on within the electrosurgical instrument;
wherein the internal aspiration collection chamber is in fluid communication with at least one aspiration inlet; and
an aspiration system for removing material from a surgical site, the aspiration system including at least one conduit formed by a channel extending through the shaft, the internal aspiration collection chamber and the at least one aspiration inlet;
wherein the at least one active electrode includes a support arm extending from a substantially planar outer surface of the at least one active electrode inwardly toward a longitudinal axis of the channel of the aspiration system whereby the support arm includes a threaded support orifice configured to be threadably attached to threads at a distal end of the channel of the aspiration system.

US Pat. No. 10,335,224

METHOD OF DESTROYING TISSUE CELLS BY ELECTROPORATION

AngioDynamics, Inc., Lat...

1. A method of treating a living human body by destroying tissue cells, comprising:positioning one or more electrodes over skin cells of the living human body, the skin cells of the living human body overlying fat cells of the living human body, the one or more positioned electrodes defining a target area containing fat cells to be killed in the living human body; and
treating the living human body by applying electrical pulses through the one or more positioned electrodes in an amount above an upper limit of electroporation to irreversibly open pores in membranes of the fat cells in the target area, thereby killing the fat cells in the target area.

US Pat. No. 10,335,222

INDUCTION COIL VAPOR GENERATOR

NxThera, Inc., Maple Gro...

1. An inductive vapor generator, comprising:an outer support assembly comprising a first tube wherein the first tube is thermally insulating and electrically insulating;
a coil disposed around the outer support assembly;
an inner assembly comprising a second tube, the inner assembly being disposed within the outer support assembly wherein the second tube is thermally conductive and electrically insulating;
a plurality of microtubes disposed within the inner assembly, the plurality of microtubes being configured to receive a fluid from a fluid source;
a first cap pressure-fit on a first end of the inner assembly and a second cap pressure-fit on a second end of the inner assembly, wherein each of the first and the second pressure-fit caps includes an o-ring seal;
a sintered filter disposed within the inner assembly; and
a radiofrequency generator electrically coupled to the coil, the radiofrequency generator being configured to apply a current to the coil to inductively heat the fluid in the plurality of microtubes to convert the fluid into a heated condensable vapor.

US Pat. No. 10,335,221

METHODS AND DEVICES TO TREAT NASAL AIRWAYS

AERIN MEDICAL, INC., Sun...

1. A method of treating an airway in a patient, the method comprising:advancing a cryotherapy balloon of a treatment device through a nostril of the patient and into the airway in an uninflated configuration;
inflating the cryotherapy balloon by circulating a low-temperature liquid into an interior of the cryotherapy balloon, wherein inflating the cryotherapy balloon causes the cryotherapy balloon to contact nasal mucosa lining the airway;
removing energy from submucosal tissue underlying the nasal mucosa by maintaining the cryotherapy balloon in an inflated configuration and continuing to circulate the low-temperature liquid through the interior of the cryotherapy balloon, to change a property of the submucosal tissue;
deflating the cryotherapy balloon by removing the low-temperature liquid from the interior of cryotherapy balloon; and
removing the cryotherapy balloon from the airway.

US Pat. No. 10,335,220

BONE POSITIONING GUIDE

Treace Medical Concepts, ...

1. A method of positioning a bone comprising:engaging a surface of a bone engagement member of a bone positioning guide with a first bone;
placing a tip of the bone positioning guide in contact with a second bone, the second bone being different from the first bone; and
moving the bone engagement member with respect to the tip to change the position of the first bone with respect to the second bone, wherein moving the bone engagement member comprises correcting an alignment of the first bone in more than one plane with respect to the second bone, including about an axis in a frontal plane.

US Pat. No. 10,335,219

METHOD AND IMPLANT FOR STABILIZING TWO BONE PORTIONS SEPARATED BY A CUT OR FRACTURE

WOODWELDING AG, Stanssta...

1. A set of tools for stabilizing two bone portions separated by a cut or fracture in a human or animal patient, the set of tools comprising an implantation tool and mounted or mountable to the implantation tool an implant, wherein the implant comprises a plurality of anchoring pins and at least one bridge portion connecting proximal ends of the anchoring pins and wherein a material having thermoplastic properties is arranged on lateral surfaces of the anchoring pins or in a perforated sheath of at least one anchoring pin, wherein said lateral surfaces of the anchoring pins or said perforated sheath is arranged on the implant for being in contact with bone tissue on implantation, wherein the set of tools further comprises a fixation/guide tool comprising an axial tunnel and resilient outwards flaring distal half portions with distal faces equipped for fixation on a bone surface, wherein the distal half portions flare outwards with respect to a longitudinal axis of the fixation/guide tool.

US Pat. No. 10,335,218

MULTICHANNEL CANNULA AND METHODS FOR USING SAME

Spinal Generations, LLC, ...

1. A method for delivering a substance to bone, comprising:placing a stabilizing wire in a bone;
creating a hole in the bone around the stabilizing wire;
providing a multichannel cannula, comprising:
a first channel having an open proximal end and an open distal end, wherein the first channel is configured to receive the stabilizing wire; and
a second channel having an inlet portal and an exit portal, wherein the inlet portal and the exit portal are in fluid communication for continuous flow of the substance from the inlet portal to the exit portal;
inserting the multichannel cannula into the hole in the bone such that the first channel receives the stabilizing wire; and
delivering the substance into the bone by introducing the substance into the inlet portal of the second channel such that the substance flows continuously in the second channel between the inlet portal and the exit portal, wherein the stabilizing wire remains placed in the bone and received by the first channel during delivery of the substance to the bone.

US Pat. No. 10,335,217

PEDICLE SCREW WITH LARGE-DIAMETER BONE THREAD

Aesculap AG, (DE)

1. A pedicle screw system comprising a receiving sleeve for a longitudinal support, a bone screw and a shank head element;the bone screw comprising a bone thread formed as an external thread and a connection thread formed as an inner thread;
the shank head element at a proximal end having a head on which the receiving sleeve is mounted, and the shank head element at a distal end having a connection thread formed as an external thread and screwed into the connection thread of the bone screw;
the connection threads both being formed as multi-threads, each having a distal connection thread portion and a proximal connection thread portion;
the distal connection thread portions and the proximal connection thread portions having an identical thread pitch; and
the distal connection thread portions having a diameter smaller than that of the proximal connection thread portions.

US Pat. No. 10,335,216

SCREW IMPLANTS FOR BONE FUSION

Globus Medical, Inc., Au...

1. A fixation screw assembly for fusing a sacroiliac joint comprising:a fixation member including a head member and a bone-engaging portion coupled to the head member, the head member having a generally spherical outer surface and a groove; and
a washer member having an inner annular lip, wherein the washer member is operatively coupled to the fixation member around the head member, an inner surface of the washer member being generally spherical and corresponding to the generally spherical outer surface of the head member, and the inner annular lip extends inwardly from the inner surface of the washer member, wherein the washer member is capable of polyaxial movement relative to a longitudinal axis of the fixation member,
wherein when the washer member is sufficiently angled relative to the longitudinal axis of the fixation member, the lip of the washer member bottoms out on the groove of the head member on one side and the lip of the washer member is positioned above the head member of the fixation member on an opposite side such that the lip directly contacts the head at the groove on the one side and the lip does not directly contact the head on the opposite side.

US Pat. No. 10,335,215

BONE SCREW WITH SELF-CONSTRAINED FLEXIBILITY

1. A bone screw comprising:a longitudinal core member defining a longitudinal axis and having an outer surface and a helical groove recessed from the outer surface, the helical groove having a groove cross-section defined by opposed sidewalk and a bottom surface connecting the opposed sidewalk and forming a first portion of the groove cross-section that is positioned closest radially to the longitudinal axis, wherein a minor diameter of the core member measured radially between diametrically opposite portions of the bottom surface of the helical groove is greater than a depth of the helical groove measured radially from the first portion of the groove cross-section to the outer surface of the core member; and
a helical thread body configured to be accommodated in the helical groove,
wherein when the thread body is assembled in the helical groove of the core member and when the core member is straight along the longitudinal axis, the thread body is configured to abut one opposed sidewall without abutting the other opposed sidewall along a full turn of the thread body,
wherein when the thread body and the core member are assembled and the thread body is contacting the bottom surface of the helical groove, a portion of the thread body that extends outside the helical groove has a height measured radially outwardly from the outer surface of the core member that is greater than the depth of the helical groove over an uninterrupted length of the thread body that covers a majority of the entire thread body, and
wherein the thread body is configured to slide in the helical groove between the opposed sidewalls of the helical groove in a direction parallel to the longitudinal axis.

US Pat. No. 10,335,214

MULTIPLEXED SCREWS

DePuy Synthes Products, I...

1. A bone fixation element, comprising:a shaft extending substantially along a longitudinal axis of the fixation element; and
a head extending from and integrally formed with the shaft, the head defining a plurality of fixation element openings distributed about a perimeter thereof, each of the fixation element openings extending through the head from a proximal surface thereof to a distal surface of the head, each of the fixation element openings extending through the head along an opening axis, wherein at least two of the fixation element openings are only partially enclosed by the head, wherein a first one of the openings includes a threading along an inner surface thereof to lockingly engage a corresponding threading on a head of a bone fixation element to be inserted therethrough.

US Pat. No. 10,335,213

BONE PLATE WITH A BONE SCREW

1. An osteosynthesis device with a bone plate and with at least one bone screw, wherein the bone plate has at least one through-hole with a conical inner thread formed at least in part in the through-hole, the bone screw moreover has a screw shank and also a screw head with a conical thread, with the possibility of forming a connection at a variable and stable angle between bone screw and bone plate by receiving the screw head with conical outer thread in the respective through-hole of the bone plate,characterized in that the thread in the screw head has a first portion with a first conicity and a second portion with a second conicity, wherein a zone of discontinuity with respect to the conicity is present between the first portion and the second portion.

US Pat. No. 10,335,212

VARIABLE ANGLE SCREWS, PLATES AND SYSTEMS

Orthofix S.R.L., Verona ...

1. A variable angle orthopedic plate, the plate comprising:an upper surface;
a bone facing surface;
at least one variable angle through hole between the upper surface and the bone facing surface, the through hole defined by a wall having a generally cylindrical shape with a central hole axis with a constant total radius from the upper surface to the bone facing surface, wherein the wall comprises a single continuous thread, the apex of which defines a central hole aperture of radius (raperture), and a thread trough defining a total hole radius of (rhole),
wherein the thread has at least one indentation along its length, each indentation having a radius (rindent), wherein raperture wherein the surface of the wall defining the variable angle hole engages a threaded head of an orthopedic fastener at a first angle aligned with the central hole axis and at least one other angle measured between the central hole axis and an axis of an orthopedic fastener.

US Pat. No. 10,335,211

HIGHLY-VERSATILE VARIABLE-ANGLE BONE PLATE SYSTEM

DePuy Synthes Products, I...

1. A method of forming a thread in an outer surface of a head of a bone screw that is elongate along a central axis, the method comprising the steps of:orienting a thread cutter in a first orientation with respect to the bone screw, the thread cutter including a cutting bit having an apex, wherein the cutting bit extends along a longitudinal axis that normally intersects the apex of the cutting bit, and when the thread cutter is in the first orientation the longitudinal axis is perpendicular to a central axis of the bone screw;
after the orienting step, rotating the bone screw at least one complete revolution about the central axis relative to the cutting bit while 1) maintaining the thread cutter in the first orientation with respect to the bone screw; 2) maintaining contact between the cutting bit and the outer surface; and 3) translating the bone screw relative to the cutting bit with respect to the central axis a first distance per revolution; and
after the rotating step, further rotating the bone screw another at least one complete revolution about the central axis relative to the cutting bit while 1) maintaining the thread cutter in the first orientation with respect to the bone screw; 2) maintaining contact between the cutting bit and the outer surface; and 3) translating the bone screw relative to the cutting bit with respect to the central axis a second distance per revolution that is different than the first distance per revolution,
wherein both of the rotating steps result in the forming of a cross-sectional profile of the thread, the cross-sectional profile having a plurality of peaks, a plurality of troughs each of which are positioned between adjacent ones of the plurality of peaks, and a plurality of flanks each of which connect one of the plurality of peaks to an adjacent one of the plurality of troughs, each of the plurality of peaks being spaced farther from the central axis than adjacent ones of the plurality of flanks, each of the plurality of flanks being spaced farther from the central axis than the adjacent one of the plurality of troughs.

US Pat. No. 10,335,210

ANATOMIC PLATES FOR MEDIAL PROXIMAL TIBIA

Biomet Manufacturing, LLC...

1. A bone plate comprising:a proximal head extending from a first head end to a second head end;
a distal shaft connected to the proximal head and extending from a first shaft end to a second shaft end; and
a strut connecting the second end of the proximal head and a mid-section of the distal shaft;
wherein the first head end is connected to the first shaft end, and the proximal head extends perpendicularly medially from the distal shaft;
wherein the proximal head is offset from the distal shaft in an anterior direction by approximately 10 millimeters;
wherein the proximal head is shaped to conform to a proximal medial portion of a tibia;
wherein the proximal head is shaped to conform to a medial condyle of the tibia; and
wherein the proximal head is shaped to conform to an anterior medial portion of the medial condyle.