US Pat. No. 10,336,858

PREPARATION OF BROMINE-CONTAINING POLYMERS USEFUL AS FLAME RETARDANTS

Bromine Compounds Ltd., ...

1. A process for preparing bromine-containing polymer, comprising a Friedel-Crafts alkylation reaction of tetrabromoxylylene dihalide, or tetrabromoxylylene dihalide in combination with pentabromobenzyl halide, with a reactant having one or more six-membered aromatic rings of Formula (II):
where R is a linear or branched aliphatic chain; k is an integer from 0 to 3; m is 0 or 1; and Z is selected from the group consisting of null, O, S and a linear or branched alkylene, wherein the reaction takes place in a solvent in the presence of a Friedel-Crafts catalyst, and isolating from the reaction mixture the bromine-containing polymer of Formula (I):

wherein R, k, m, and Z are as defined above; each of a1 and a2 is independently an integer from 1 to 3; and each of b1 and b2 is independently an integer from 1 to 3, such that a1+b1?3 and a2+b2?3.

US Pat. No. 10,336,852

AMPHIPHILIC GRAFT COPOLYMERS

Becton, Dickinson and Com...

1. An amphiphilic copolymer of the formula (I):
wherein R is hydrogen, alkyl, substituted alkyl, vinylic substituted alkyl, hydrocarbyl, substituted hydrocarbyl, or vinylic substituted hydrocarbyl group; the molar value of m is in the range from 2 to 40 mole percent; the molar value of n is in the range from 60 to 98 mole percent; and p is in the range from 30 to 500 ethylene oxide units.

US Pat. No. 10,336,815

PHAGE-DISPLAYED ANTIBODY LIBRARIES AND USES THEREOF

Academia Sinica, Taipei ...

1. A phage-displayed single-chain variable fragment (scFv) library comprising a plurality of scFvs that are expressed by a phage and exhibit binding affinity and specificity to an H1 hemagglutinin of influenza virus, wherein the plurality of scFvs respectively comprises the amino acid sequences of SEQ ID NOs: 24-26, 34-37 and 44-46.

US Pat. No. 10,336,785

METHODS FOR SYNTHESIZING NUCLEOTIDE ANALOGUES WITH DISULFIDE LINKERS

Qiagen Sciences, LLC, Ge...

1. A compound wherein the structure is:

US Pat. No. 10,336,782

SUBSTITUTED CYCLOPENTADIENYL COBALT COMPLEX AND METHOD FOR PRODUCTION THEREOF, AND COBALT-CONTAINING THIN FILM AND METHOD FOR PRODUCTION THEREOF

SAGAMI CHEMICAL RESEARCH ...

5. A method for producing a cobalt-containing thin film using, as a raw material in a vapor phase deposition method based on a chemical reaction, a cobalt complex represented by Formula (1)
[where R1 is a silyloxy group represented by Formula (2)

where R6, R7 and R8 each independently represent an alkyl group having from 1 to 6 carbon atoms; R2 is a hydrogen atom, an alkyl group having from 1 to 6 carbon atoms, or a silyloxy group represented by Formula (2); R3, R4 and R5 each independently represent a hydrogen atom or an alkyl group having from 1 to 6 carbon atoms; and L is a diene having from 4 to 10 carbon atoms].

US Pat. No. 10,336,781

RECYCLABLE METATHESIS CATALYSTS

THE TRUSTEES OF BOSTON CO...

1. A composition comprising a transition metal catalyst having the following structure:wherein:M is a transition metal;
R is an alkyl, alkenyl, alkynyl, aryl, alkoxy carbonyl, alkylsulfonyl, or alkylsulfinyl;
each optionally substituted with an alkyl, alkoxy, aryl or heteroaryl moiety;
R1 and R2 each is or together are, an electron withdrawing anionic ligand;
a, b, c, and d each are H, a halogen atom or an alkyl, alkenyl, alkynyl, aryl, alkoxy, alkenyloxy, alkynyloxy, aryloxy, alkoxycarbonyl, alkylamino, alkylthio, alkylsulfonyl, or alkylsulfinyl; each optionally substituted with an alkyl, halogen, aryl or heteroaryl moiety;
X is oxygen, sulfur, nitrogen or phosphorus; and
Y is an electron-donating heterocyclic carbene ligand.

US Pat. No. 10,336,780

DIOXOLANE ANALOGUES OF URIDINE FOR THE TREATMENT OF CANCER

MEDIVIR AB, Stockholm (S...

1. A compound represented by formula Ia:
wherein:
R1 is NH2;
R2 is H;
R13 is phenyl or naphthyl any of which is optionally substituted with 1, 2 or 3 R22;
R15 is methyl;
R16 is C3-C7cycloalkyl;
each R22 is independently selected from halo, C1-C6alkyl, C2-C6alkenyl, C1-C6haloalkyl, C1-C6alkoxy, C1-C6haloalkoxy, phenyl, hydroxyC1-C6alkyl, C3-C6cycloalkyl, C1-C6alkylcarbonyl, C3-C6cycloalkylcarbonyl, carboxyC1-C6alkyl, hydroxy, amino CN, and NO2, or any two R22 groups attached to adjacent ring carbon atoms can combine to form —O—(CR23R23?)1-6—O—;
R23 and R23? are independently H or C1-C3alkyl;
or a pharmaceutically acceptable salt and/or solvate thereof.

US Pat. No. 10,336,774

N-AZASPIROCYCLOALKANE SUBSTITUTED N-HETEROARYL COMPOUNDS AND COMPOSITIONS FOR INHIBITING THE ACTIVITY OF SHP2

Novartis AG, Basel (CH)

1. A method of treatment of lung cancer comprising administering a compound of formula I, or a pharmaceutically acceptable salt thereof, to a person in need of such treatment in an effective amount for the therapeutic treatment of lung cancer:
in which:
p is selected from 0 and 1;
q is selected from 0 and 1;
Y1 is N;
Y2 is CR6;
R1 is ?XR1a; wherein R1a is selected from C6-10aryl, C3-8cycloalkyl, C3-8cycloalkenyl and a 5-9 member heteroaryl group containing from 1 to 4 heteroatoms or groups independently selected from N, C(O), O and S; wherein said aryl or heteroaryl of R1a is substituted with 1 to 5 R9 groups independently selected from halo, amino, hydroxy, N3, C1-4alkyl, C1-4alkoxy, dimethyl-amino, hydroxy-substituted-C1-4alkyl, halo-substituted-C1-4alkyl, amino-substituted-C1-4alkyl, —C(O)OR10, —C(O)NH2 and —NHC(O)R10, wherein R10 is selected from hydrogen, phenyl and naphthyl; wherein said phenyl of R10 is unsubstituted or substituted with methoxy; and X is selected from a bond, S(O)m, O, C(O), CR10aR10b, NR11; wherein m is selected from 0, 1 and 2; each R10a and R10b is independently selected from halo and C1-4alkyl; and R11 is selected from hydrogen and C1-4alkyl;
R2a and R2b are independently selected from hydrogen, C1-4alkyl, C1-4alkoxy, amino, hydroxy, C3-8cycloalkyl and C1-4alkyl-amino;
R3a and R3b are independently selected from hydrogen, halo, C1-4alkyl, C1-4alkoxy, amino, hydroxy, C3-8cycloalkyl and C1-4alkyl-amino;
R4a and R4b are independently selected from hydrogen, halo, C1-4alkyl, C1-4alkoxy, amino, hydroxy, C3-8cycloalkyl and C1-4alkyl-amino;
R5a and R5b are independently selected from hydrogen, C1-4alkyl, C1-4alkoxy, amino, hydroxy, C3-8cycloalkyl and C1-4alkyl-amino;
R6 is selected from hydrogen, halo, cyano, C1-4alkyl, C1-4alkoxy, amino-carbonyl, halo-substituted C1-4alkyl, halo-substituted C1-4alkoxy, hydroxy-substituted C1-4alkyl, amino-substituted C1-4alkyl, —S(O)1-2R6a, —C(S)R6a, —C(O)NR6aR6b, —C(NH)NR6aR6b and —NR6aC(O)R6b; wherein R6a and R6b are independently selected from hydrogen and C1-4alkyl;
R7 and R8 together with the carbon atom to which they are both attached form a 3 to 7 member saturated or partially unsaturated ring that can optionally contain 1 to 3 heteroatoms or groups independently selected from N, C(O), O and S(O)m; wherein m is selected from 0, 1 and 2; wherein said saturated ring formed by R7 and R8 can be unsubstituted or substituted with 1 to 3 groups independently selected from amino, hydroxy, methoxy, halo, methyl, amino-methyl, methyl-amino and
isobutyryloxy.

US Pat. No. 10,336,772

BICARBAZOLE COMPOUND, MATERIAL FOR ORGANIC LIGHT-EMITTING DEVICE INCLUDING BICARBAZOLE COMPOUND, AND ORGANIC LIGHT-EMITTING DEVICE INCLUDING BICARBAZOLE COMPOUND

SAMSUNG ELECTRONICS CO., ...

1. A bicarbazole compound represented by Formula 1:[Ar1]n1-(L1)a1-[Ar2]n2  Formula 1
wherein, in Formula 1,
Ar1 is represented by one of Formulae 1-1, 1-2, and 1-4 to 1-21:

wherein, in Formulae 1-1, 1-2, and 1-4 to 1-21,
at least one hydrogen is substituted with a group serving as a binding site to L1, Ar2 is represented by Formula 1B:

wherein, in Formula 1B,
X1 to X16 are each independently selected from a nitrogen atom and CR21,
R21 is selected from a binding site to L1, a binding site to L2, hydrogen, a deuterium atom, a substituted or unsubstituted C1-C10 alkyl group, a substituted or unsubstituted aryl group comprising 6 to 30 ring-forming atoms, and a substituted or unsubstituted heteroaryl group comprising 5 to 30 ring-forming atoms,
R21 is optionally bound to adjacent R21 to form a condensed ring,
two substituents of X1 to X16 each comprises a C-(L2-binding site) structure,
R22 and R23 are each independently selected from a binding site to L1, a substituted or unsubstituted aryl group comprising 6 to 30 ring-forming atoms, and a substituted or unsubstituted heteroaryl group comprising 5 to 30 ring-forming atoms,
at least one selected from R21 to R23 is a binding site to L1,
n1 and n2 are each independently an integer from 1 to 20,
L1 and L2 are each independently selected from a single bond and a substituted or unsubstituted arylene group comprising 6 to 30 ring-forming atoms, and
a1 and a2 are each independently an integer from 0 to 3.

US Pat. No. 10,336,769

GONADOTROPIN-RELEASING HORMONE RECEPTOR ANTAGONISTS AND METHODS RELATING THERETO

Neurocrine Biosciences, I...

1. A compound chosen fromor a pharmaceutically acceptable salt thereof.

US Pat. No. 10,336,767

CRYSTALLINE FORMS OF THERAPEUTIC COMPOUNDS AND USES THEREOF

Kala Pharmaceuticals, Inc...

4. A pharmaceutical composition comprising the crystalline form of claim 1 and a pharmaceutically acceptable carrier.

US Pat. No. 10,336,766

ANTICANCER DRUG CANDIDATES

The Scripps Research Inst...

1. An enediyne compound comprising a structure represented by formula (I):
or a pharmaceutically acceptable salt thereof, wherein:
R1, R2, R3, R4, are each independently: H, OH, F, Cl, Br, R?, OR?, CH3, NH2, NHR?, NR?2, SH, SR?, C(O)R, RCO2R?, halogen, or alkyl;
R5 and R6 are each independently OH, F, Cl, Br, OR?, NH2, NHR?, NR?2, SH, SR?, C(O)R, RCO2R?;
R7 is H or alkyl;
R? and R are independently: H, C1-C10 alkyl, or aryl;
X is N.

US Pat. No. 10,336,762

PYRROLO[1,2-B]PYRIDAZINE DERIVATIVES

Gilead Sciences, Inc., F...

1. A compound of Formula (I)
wherein:
R1 and R2 are each independently selected from:
a) C1-10 alkyl optionally substituted with Z1;
b) C3-10 cycloalkyl optionally substituted with Z1;
c) 5-10 membered heteroaryl optionally substituted with Z1;
d) C6-10 aryl optionally substituted with Z1;
e) 4-7 membered monocyclic heterocyclyl optionally substituted with Z1;
f) 6-12 membered bicyclic heterocyclyl optionally substituted with Z1; or
g) —N(R12)(R12), —S(O)2R12, —S(O)2N(R12)(R12), or —H;
R3 and R4 are each independently selected from:
a) H, halo, —NO2, —CN, —O—R12, —C(O)—R12, —C(O)—N(R12)(R12), —N(R12)(R12), —N(R12)C(O)—R12, —N(R12)C(O)O—R12, —N(R12)S(O)2(R12), —N(R12)C(O)—N(R12)(R12), —S(O)2R12 or —S(O)2N(R12)(R12);
b) C1-9 alkyl optionally substituted with Z1;
c) C2-9 alkynyl optionally substituted with Z1;
d) C2-9 alkenyl optionally substituted with Z1;
e) 5-10 membered heteroaryl optionally substituted with Z1;
f) C6-10 aryl optionally substituted with Z1;
g) 4-12 membered heterocyclyl optionally substituted with Z1; or
h) C3-10 cycloalkyl optionally substituted with Z1;
R5, R6 and R7 are each independently selected from:
a) H, halo, —NO2, —CN, —O—R12, —C(O)—R12, —C(O)—N(R12)(R12), —N(R12)(R12), —N(R12)C(O)—R12, —N(R12)C(O)O—R12, or —N(R12)S(O)2(R12;
b) C1-5 alkyl optionally substituted with Z1; or
c) Cyclopropyl, oxetanyl or azetidinyl optionally substituted with Z1;
Z1 is independently oxo, halo, —NO2, —N3, —CN, C1-9 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-15 cycloalkyl, C1-8 haloalkyl, aryl, heteroaryl, heterocyclyl, —O—R12, —C(O)—R12, —C(O)O—R12, —C(O)—N(R12)(R12), —N(R12)(R12), —N(R12)2(R12)+, —N(R12)C(O)—R12, —N(R12)C(O)O—R12, —N(R12)C(O)N(R12)(R12), —N(R12)S(O)2(R12), —NR12S(O)2N(R12)(R12), —NR12S(O)2O(R12), —OC(O)R12, —OC(O)OR12, —OC(O)—N(R12)(R12), —Si(R12)3, —S—R12, —S(O)R12, —S(O)(NH)R12, —S(O)2R12 or —S(O)2N(R12)(R12);
wherein any alkyl, alkenyl, alkynyl, cycloalkyl, haloalkyl, aryl, heteroaryl or heterocyclyl is optionally substituted with Z1a;
each Z1a is independently oxo, halo, —NO2, —CN, —N3, C1-9 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-15 cycloalkyl, C1-8 haloalkyl, aryl, heteroaryl, heterocyclyl, —O—R12, —C(O)R12, —C(O)O—R12, —C(O)N(R12)(R12), —N(R12)(R12), —N(R12)2(R12)+, —N(R12)—C(O)R12, —N(R12)C(O)O(R12), —N(R12)C(O)N(R12)(R12), —N(R12)S(O)2(R12), —N(R12)S(O)2—N(R12)(R12), —N(R12)S(O)2O(R12), —OC(O)R12, —OC(O)OR12, —OC(O)—N(R12)(R12), —Si(R12)3, —S—R12, —S(O)R12, —S(O)(NH)R12, —S(O)2R12 or —S(O)2N(R12)(R12);
wherein any alkyl, alkenyl, alkynyl, cycloalkyl, haloalkyl, aryl, heteroaryl or heterocyclyl is optionally substituted with Z1b;
each R12 is independently H, C1-9 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-15 cycloalkyl, aryl, heteroaryl or heterocyclyl;
wherein any alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heteroaryl or heterocyclyl is optionally substituted with Z1a;
each Z1b is independently oxo, hydroxy, halo, —NO2, —N3, —CN, C1-9 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-15 cycloalkyl, C1-8 haloalkyl, aryl, heteroaryl, heterocyclyl, —O(C1-9 alkyl), —O(C2-6 alkenyl), —O(C2-6 alkynyl), —O(C3-15 cycloalkyl), —O(C1-8 haloalkyl), —O(aryl), —O(heteroaryl), —O(heterocyclyl), —NH2, —NH(C1-9 alkyl), —NH(C2-6 alkenyl), —NH(C2-6 alkynyl), —NH(C3-15 cycloalkyl), —NH(C1-8 haloalkyl), —NH(aryl), —NH(heteroaryl), —NH(heterocyclyl), —N(C1-9 alkyl)2, —N(C3-15 cycloalkyl)2, —N(C2-6 alkenyl)2, —N(C2-6 alkynyl)2, —N(C3-15 cycloalkyl)2, —N(C1-8 haloalkyl)2, —N(aryl)2, —N(heteroaryl)2, —N(heterocyclyl)2, —N(C1-9 alkyl)(C3-15 cycloalkyl), —N(C1-9 alkyl)(C2-6 alkenyl), —N(C1-9 alkyl)(C2-6 alkynyl), —N(C1-9 alkyl)(C3-15 cycloalkyl), —N(C1-9 alkyl)(C1-8 haloalkyl), —N(C1-9 alkyl)(aryl), —N(C1-9 alkyl)(heteroaryl), —N(C1-9 alkyl)(heterocyclyl), —C(O)(C1-9 alkyl), —C(O)(C2-6 alkenyl), —C(O)(C2-6 alkynyl), —C(O)(C3-15 cycloalkyl), —C(O)(C1-8 haloalkyl), —C(O)(aryl), —C(O)(heteroaryl), —C(O)(heterocyclyl), —C(O)O(C1-9 alkyl), —C(O)O(C2-6 alkenyl), —C(O)O(C2-6 alkynyl), —C(O)O(C3-15 cycloalkyl), —C(O)O(C1-8 haloalkyl), —C(O)O(aryl), —C(O)O(heteroaryl), —C(O)O(heterocyclyl), —C(O)NH2, —C(O)NH(C1-9 alkyl), —C(O)NH(C2-6 alkenyl), —C(O)NH(C2-6 alkynyl), —C(O)NH(C3-15 cycloalkyl), —C(O)NH(C1-8 haloalkyl), —C(O)NH(aryl), —C(O)NH(heteroaryl), —C(O)NH(heterocyclyl), —C(O)N(C1-9 alkyl)2, —C(O)N(C3-15 cycloalkyl)2, —C(O)N(C2-6 alkenyl)2, —C(O)N(C2-6 alkynyl)2, —C(O)N(C3-15 cycloalkyl)2, —C(O)N(C1-8 haloalkyl)2, —C(O)N(aryl)2, —C(O)N(heteroaryl)2, —C(O)N(heterocyclyl)2, —NHC(O)(C1-9 alkyl), —NHC(O)(C2-6 alkenyl), —NHC(O)(C2-6 alkynyl), —NHC(O)(C3-15 cycloalkyl), —NHC(O)(C1-8 haloalkyl), —NHC(O)(aryl), —NHC(O)(heteroaryl), —NHC(O)(heterocyclyl), —NHC(O)O(C1-9 alkyl), —NHC(O)O(C2-6 alkenyl), —NHC(O)O(C2-6 alkynyl), —NHC(O)O(C3-15 cycloalkyl), —NHC(O)O(C1-8 haloalkyl), —NHC(O)O(aryl), —NHC(O)O(heteroaryl), —NHC(O)O(heterocyclyl), —NHC(O)NH(C1-9 alkyl), —NHC(O)NH(C2-6 alkenyl), —NHC(O)NH(C2-6 alkynyl), —NHC(O)NH(C3-15 cycloalkyl), —NHC(O)NH(C1-8 haloalkyl), —NHC(O)NH(aryl), —NHC(O)NH(heteroaryl), —NHC(O)NH(heterocyclyl), —SH, —S(C1-9 alkyl), —S(C2-6 alkenyl), —S(C2-6 alkynyl), —S(C3-15 cycloalkyl), —S(C1-8 haloalkyl), —S(aryl), —S(heteroaryl), —S(heterocyclyl), —NHS(O)(C1-9 alkyl), —N(C1-9 alkyl)(S(O)(C1-9 alkyl), —S(O)N(C1-9 alkyl)2, —S(O)(C1-9 alkyl), —S(O)(NH)(C1-9 alkyl), —S(O)(C2-6 alkenyl), —S(O)(C2-6 alkynyl), —S(O)(C3-15 cycloalkyl), —S(O)(C1-8 haloalkyl), —S(O)(aryl), —S(O)(heteroaryl), —S(O)(heterocyclyl), —S(O)2(C1-9 alkyl), —S(O)2(C2-6 alkenyl), —S(O)2(C2-6 alkynyl), —S(O)2(C3-15 cycloalkyl), —S(O)2(C1-8 haloalkyl), —S(O)2(aryl), —S(O)2(heteroaryl), —S(O)2(heterocyclyl), —S(O)2NH(C1-9 alkyl), or —S(O)2N(C1-9 alkyl)2;
wherein any alkyl, cycloalkyl, aryl, heteroaryl, or heterocyclyl is optionally substituted with one or more halo, C1-9 alkyl, C1-8 haloalkyl, —OH, —NH2, —NH(C1-9 alkyl), —NH(C3-15 cycloalkyl), —NH(C1-8 haloalkyl), —NH(aryl), —NH(heteroaryl), —NH(heterocyclyl), —N(C1-9 alkyl)2, —N(C3-15 cycloalkyl)2, —NHC(O)(C3-15 cycloalkyl), —NHC(O)(C1-8 haloalkyl), —NHC(O)(aryl), —NHC(O)(heteroaryl), —NHC(O)(heterocyclyl), —NHC(O)O(C1-9 alkyl), —NHC(O)O(C2-6 alkynyl), —NHC(O)O(C3-15 cycloalkyl), —NHC(O)O(C1-8 haloalkyl), —NHC(O)O(aryl), —NHC(O)O(heteroaryl), —NHC(O)O(heterocyclyl), —NHC(O)NH(C1-9 alkyl), —S(O)(NH)(C1-9 alkyl), S(O)2(C1-9 alkyl), —S(O)2(C3-15 cycloalkyl), —S(O)2(C1-8 haloalkyl), —S(O)2(aryl), —S(O)2(heteroaryl), —S(O)2(heterocyclyl), —S(O)2NH(C1-9 alkyl), —S(O)2N(C1-9 alkyl)2, —O(C3-15 cycloalkyl), —O(C1-8 haloalkyl), —O(aryl), —O(heteroaryl), —O(heterocyclyl), or —O(C1-9 alkyl); and
with the proviso that when R1 is C3 alkyl, R2 is C5 alkyl substituted with F and hydroxyl, R3, R5, R6, R7 are H, and R4 is CN, then R1 is substituted with oxo, halo, —NO2, —N3, —CN, C2-9 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-15 cycloalkyl, C1-8 haloalkyl, aryl, heteroaryl, heterocyclyl, —O—R12, —C(O)—R12, —C(O)O—R12, —C(O)—N(R12)(R12), —N(R12)(R12), —N(R12)2(R12)+, —N(R12)C(O)—R12, —N(R12)C(O)O—R12, —N(R12)C(O)N(R12)(R12), —N(R12)S(O)2(R12), —NR12S(O)2N(R12)(R12), —NR12S(O)2O(R12), —OC(O)R12, —OC(O)OR12, —OC(O)—N(R12)(R12), —Si(R12)3, —S—R12, —S(O)R12, —S(O)(NH)R12, —S(O)2R12 or —S(O)2N(R12)(R12);
wherein any alkyl, alkenyl, alkynyl, cycloalkyl, haloalkyl, aryl, heteroaryl or heterocyclyl is optionally substituted with Z1a;
or a pharmaceutically acceptable salt, stereoisomer, mixture of stereoisomers, or deuterated analog thereof.

US Pat. No. 10,336,756

(S)-2-(1-AMINOPROPYL)-5-FLUORO-3-PHENYLQUINAZOLIN-4(3H)-ONE PRECURSOR OF A QUINAZOLINONE AS INHIBITOR OF HUMAN PHOSPHATIDYLINOSITOL 3-KINASE DELTA

ICOS CORPORATION, Foster...

2. A composition, comprising a compound having a structure

US Pat. No. 10,336,754

PYRIMIDINONES AS FACTOR XIA INHIBITORS

Bristol-Myers Squibb Comp...

1. A method for the treatment or prophylaxis of a venous cardiovascular thromboembolic disorder comprising administering to a patient in need thereof a therapeutically effective amount of a compound of Formula (VII):
or a pharmaceutically acceptable salt thereof, wherein:
ring A is independently selected from

ring B is independently selected from

R1 is independently selected from H and C1-4 alkyl;
R10 is independently selected from H, F, Cl, CF3, CHF2, and COOH;
R3c is independently selected from H, CHF2, CD3, CH3, and

R8b is independently selected from H and F; and
R8c is independently selected from H, F, Cl, CH3, and OCH3.

US Pat. No. 10,336,751

TRICYCLIC 4-PYRIDONE-3-CARBOXYLIC ACID DERIVATIVES FOR THE TREATMENT AND PROPHYLAXIS OF HEPATITIS B VIRUS INFECTION

Hoffmann-La Roche Inc., ...

1. A compound of formula (I),
wherein:
R1, R2, R3 and R4 are independently selected from C1-6alkyl, haloC1-6alkyl, hydrogen, halogen, amino, cyano, pyrrolidinyl and OR8;
R5, R6, R7 are independently selected from hydrogen, C1-6alkyl or haloC1-6alkyl;
R8 is hydrogen; C1-6alkyl; haloC1-6alkyl; C3-7cycloalkylC1-6alkyl; phenylC1-6alkyl; hydroxyC1-6alkyl; C1-6alkoxyC1-6alkyl; C1-6alkylsulfanylC1-6alkyl; C1-6alkylsulfonylC1-6alkyl; cyanoC1-6alkyl; aminoC1-6alkyl; C1-6alkylaminoC1-6alkyl; diC1-6alkylaminoC1-6alkyl; C1-6alkylcarbonylaminoC1-6alkyl; C1-6alkylsulfonylaminoC1-6alkyl; C1-6alkoxycarbonylaminoC1-6alkyl; pyrazolylC1-6alkyl or triazolylC1-6alkyl;
or a pharmaceutically acceptable salt, or an enantiomer, or diastereomer thereof.

US Pat. No. 10,336,749

METHOD FOR THE PREPARATION OF (4S)-4-(4-CYANO-2-METHOXYPHENYL)-5-ETHOXY-2,8-DIMETHYL-1,4-DIHYDRO-1-6-NAPHTHYRIDINE-3-CARBOXAMIDE AND THE PURIFICATION THEREOF FOR USE AS AN ACTIVE PHARMACEUTICAL INGREDIENT

BAYER PHARMA AKTIENGESELL...

1. A process for preparing a compound of the formula (I)
comprising separating a racemic compound of the formula (XIII) into its enantiomers, wherein the compound of the formula (XIII)

is prepared by reacting a compound of the formula (XVIII)

with an orthoester (XX)

where R may be H or methyl, wherein
the compound of the formula (XVIII)

is prepared by reacting compounds of the formula (XVI a,b)

with a compound of the formula (IX)

and wherein
the compound of the formula (XVI a,b) is prepared by reacting a compound of the formula (VI)

with a compound of the formula (XVII)

US Pat. No. 10,336,748

METHYOXY-SUBSTITUTED PYRROLOPYRIDINE MODULATORS OF RORC2 AND METHODS OF USE THEREOF

Pfizer Inc., New York, N...

1. A compound of Formula I:or a pharmaceutically acceptable salt thereof, wherein,X is phenyl optionally substituted with one, two, three, four or five substituents independently selected from the group consisting of —CH3, —CH2CH3, —CH2OH, —OH, —OCH3, —SCH3, —OCH2CH3, —OCH2CH2OH, —OCH2CH2OCH3, —F, —Cl, —Br and —CN;
R1 is —CH3 or —CH2CH3;
W is

 optionally substituted with one, two, three, four or five —CH3; and
R2 is (C1-C6)alkyl, (C3-C10)cycloalkyl, phenyl, tetrahydrothiophenyl, thietanyl or indanyl, optionally substituted with one, two, three, four or five substituents independently selected for each occurrence from the group consisting of —F, —Cl, —Br, —OH, (C1-C3)alkyl, (C1-C3)haloalkyl and (C3-C10)cycloalkyl.

US Pat. No. 10,336,747

PYRIMIDO[4,5-B]INDOLE DERIVATIVES AND USE THEREOF IN THE EXPANSION OF HEMATOPOIETIC STEM CELLS

1. A compound of general formula I or IIor a salt thereof,wherein:Z is
1) —P(O) (OR1) (OR1),
2) —C(O)OR1,
3) —C(O)NHR1,
4) —C(O)N(R1)R1,
5) —C(O)R1,
6) —SR1,
7) —S(O)2NH2,
8) —S(O)2NHR1,
9) —S(O)2N(R1)R1,
10) —S(O)R1,
11) —S(O)2R1,
12) -L,
13) -benzyl optionally substituted with 1, 2 or 3 RA or R1 substituents,
14) -L-heteroaryl optionally substituted with one or more RA or R1 substituents attached on either or both the L and the heteroaryl groups,
15) -L-heterocyclyl optionally substituted with one or more RA or R1 substituents attached on either one or both the L and the heterocyclyl groups,
16) -L-aryl optionally substituted with one or more RA or R1 substituents attached on either or both the L and the heteroaryl groups,
17) -heteroaryl optionally substituted with one or more RA or R1 substituents, or
18) -aryl optionally substituted with one or more RA or R1 substituents, and wherein each substituent is optionally attached to the L group if it is not already present, and wherein, when (R1) and R1 are attached to a nitrogen atom, optionally they join together with the nitrogen atom to form a 3 to 7-membered ring which optionally includes one or more other heteroatom selected from N, O and S, optionally the is substituted with one or more R1 or RA;
W is
1) —OR1,
2) -L-OH,
3) -L-OR1,
4) —SR1,
5) —CN,
6) —P(O)(OR1)(OR1),
7) —NHR1,
8) —N(R1)R1,
9) -L-NH2,
10) -L-NHR1,
11) -L-N(R1)R1,
12) -L-SR1,
13) -L-S(O)R1,
14) -L-S(O)2R1,
15) -L-P(O)(OR1)(OR1),
16) —C(O)OR1,
17) —C(O)NH2,
18) —C(O)NHR1,
19) —C(O)N(R1)R1,
20) —NHC(O)R1,
21) —NR1C(O)R1,
22) —NHC(O)OR1,
23) —NR1C(O)OR1,
24) —OC(O)NH2,
25) —OC(O)NHR1,
26) —OC(O)N(R1)R1,
27) —OC(O)R1,
28) —C(O)R1,
29) —NHC(O)NH2,
30) —NHC(O)NHR1,
31) —NHC(O)N(R1)R1,
32) —NR1C(O)NHR2,
33) —NR1C(O)NHR1,
34) —NR1C(O)N(R1)R1,
35) —NHS(O)2R1,
36) —NR1S(O)2R1,
37) —S(O)2NH2,
38) —S(O)2NHR1,
39) —S(O)2N(R1)R1,
40) —S(O)R1,
41) —S(O)2R1,
42) —OS(O)2R1,
43) —S(O)2OR1,
44) -benzyl optionally substituted with 1, 2 or 3 RA or R1 substituents,
45) -L-heteroaryl optionally substituted with one or more RA or R1 substituents attached on either or both the L and the heteroaryl groups,
46) -L-heterocyclyl optionally substituted with one or more RA or R1 substituents attached on either or both the L and the heterocyclyl goups,
47) -L-aryl optionally substituted with one or more RA or R1 substituents attached on either or both the L and aryl groups,
48) -L-NR1(R1),
49) -L-(N(R1)-L)n—N(R1)R1,
50) -L-(N(R1)-L)n-heteroaryl optionally substituted with one or more RA or R1 substituents attached on either or both the L and heteroaryl groups,
51) -L-(N(R1)-L)n-heterocyclyl optionally substituted with one or more RA or R1 substituents attached on either or both the L and heterocyclyl groups,
52) -L-(N(R1)-L)n-aryl optionally substituted with one or more RA or R1 substituents attached on either or both the L and aryl groups,
53) —O-L-N(R1)R1,
54) —O-L- heteroaryl optionally substituted with one or more RA or R1 substituents attached on either or both the L and heteroaryl groups,
55) —O-L- heterocyclyl optionally substituted with one or more RA or R1 substituents attached on either or both the L and heterocyclyl groups,
56) —O-L- aryl optionally substituted with one or more RA or R1 substituents attached on either or both the L and aryl groups,
57) —O-L)2—NR1,
58) —O-L-(N(R1)-L)n—N(R1)R1,
59) —O-L-(N(R1)-L)n-heteroaryl optionally substituted with one or more RA or R1 substituents attached on either or both the L and heteroaryl groups,
60) —O-L-(N(R1)-L)n-heterocyclyl optionally substituted with one or more RA or R1 substituents attached on either or both the L and heterocyclyl groups,
61) —O-L-(N(R1)-L)n-aryl optionally substituted with one or more RA or R1 substituents,
62) —S-L-heteroaryl optionally substituted with one or more RA or R1 substituents,
63) —S-L-heterocyclyl optionally substituted with one or more RA or R1 substituents,
64) —S-L-aryl optionally substituted with one or more RA or R1 substituents attached on either or both the L and aryl groups,
65) —S-L)2NR1,
66) —S-L-(N(R1)-L)n-N(R1)R1,
67) —S-L-(N(R1)-L)n-heteroaryl optionally substituted with one or more RA substituents,
68) —S-L-(N(R1)-L)n-heterocyclyl optionally substituted with one or more RA substituents,
69) —S-L-(N(R1)-L)n-aryl optionally substituted with one or more RA substituents,
70) —NR1(R1),
71) —(N(R1)-L)n-N(R1)R1,
72) —N(R1)L)2 —NR1,
73) —(N(R1)-L)n-N(R1)RA,
74) —(N(R1)-L)n-heteroaryl optionally substituted with one or more RA or R1 substituents,
75) —(N(R1)-L)n-heterocyclyl optionally substituted with one or more RA or R1 substituents,
76) —(N(R1)-L)n-aryl optionally substituted with one or more RA or R1 substituents,
77) -heteroaryl optionally substituted with one or more RA substituents, or
78) -aryl optionally substituted with one or more RA substituents,
and wherein each substituent is optionally attached to the L group if it is not already present, and wherein when two R1 substituents are present on the same nitrogen atom, then each R1 substituent is independently selected from the list of R1 values described thereafter, and wherein n is an integer equal to either 0, 1, 2, 3, 4, or 5,
and wherein, when (R1) and R1 are attached to a nitrogen atom, optionally they join together with the nitrogen atom to form a 3 to 7-membered ring which optionally includes one or more other heteroatom selected from N, O and S, optionally the ring is substituted with one or more R1 or RA;
L is
1) —C1-6alkyl,
2) —C2-6alkenyl,
3) —C2-6alkynyl,
4) —C3-7cycloalkyl,
5) —C3-7cycloalkenyl,
6) heterocyclyl,
7) —C1-6alkyl-C3-7cycloalkyl,
8) —C1-6alkyl-heterocyclyl,
9) aryl, or
10) heteroaryl,
and wherein the alkyl, the alkenyl, the alkynyl, the cycloalkyl, the cycloalkenyl, the heterocyclyl, the aryl and the heteroaryl groups are each independently optionally substituted with one or two RA substituent;
R1 is
1) —H,
2) —C1-6alkyl,
3) —C2-6alkenyl,
4) —C2-6aIkynyl,
5) —C3-7cycloalkyl,
6) —C3-7cycloalkenyl,
7) —C1-5perfluorinated,
8) -heterocyclyl,
9) -aryl,
10) -heteroaryl,
11) -benzyl, or
12) 5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoyl, and wherein the alkyl, the alkenyl, the alkynyl, the cycloalkenyl, the perfluorinated alkyl, the heterocyclyl, the aryl, the heteroaryl and the benzyl groups are each independently optionally substituted with 1,2 or 3 RA or R1 substituents;
R2 is
1) —H,
2) —C1-6alkyl,
3) —SR1,
4) —C(O)R1,
5) —S(O)R1,
6) —S(O)2R1,
7) -benzyl optionally substituted with 1, 2 or 3 RA or R1 substituents,
8) -L-heteroaryl optionally substituted with one or more RA or R1 substituents attached on either one or both the L and the heteroaryl groups,
9) -L-heterocyclyl optionally substituted with one or more RA or R1 substituents attached on either one or both the L and the heterocyclyl groups,
10) -L-aryl optionally substituted with one or more RA or R1 substituents attached on either one or both the L and the aryl groups,
11) -heteroaryl optionally substituted with one or more RA or R1 substituents, or
12) -aryl optionally substituted with one or more RA or R1 substituents, and wherein each substituent is optionally attached to the L group if it is not already present;
RA is
1) -halogen,
2) —CF3,
3) —OH,
4) —OR1,
5) -L-OH,
6) -L-OR1,
7) —OCF3,
8) —SH,
9) —SR1,
10) —CN,
11) —NO2,
12) —NH2,
13) —NHR1,
14) —NR1R1,
15) -L-NH2,
16) -L-NHR1,
17) -L-NR4R1,
18) -L-SR1,
19) -L-S(O)R1,
20) -L-S(O)2R1,
21) —C(O)OH,
22) —C(O)OR1,
23) —C(O)NH2,
24) —C(O)NHR1,
25) —C(O)N(R1)R1,
26) —NHC(O)R1,
27) —NR1C(O)R1,
28) —NHC(O)OR1,
29) —NR1C(O)OR1,
30) —OC(O)NH2,
31) —OC(O)NHR1,
32) —OC(O)N(R1)R1,
33) —OC(O)R1,
34) —C(O)R1,
35) —NHC(O)NH2,
36) —NHC(O)NHR1,
37) —NHC(O)N(R1)R1,
38) —NR1C(O)NH2,
39) —NR1C(O)NHR1,
40) —NR1C(O)N(R1)R1,
41) —NHS(O)2R1,
42) —NR1S(O)2R1,
43) —S(O)2NH2,
44) —S(O)2NHR1,
45) —S(O)2N(R1)R1,
46) —S(O)R1,
47) —S(O)2R1,
48) —OS(O)2R1,
49) —S(O)2OR1,
50) -benzyl,
51) —N3, or
52) —C(—N?N—)(CF3),
and wherein the benzyl group is optionally substituted with 1, 2 or 3 RA or R1 substituents.

US Pat. No. 10,336,743

AMINOPYRIMIDINE KINASE INHIBITORS

Jasco Pharmaceuticals, LL...

1. A compound selected from the group consisting of:or a pharmaceutically acceptable salt thereof.

US Pat. No. 10,336,742

PROCESS FOR PREPARING THIAZOLE DERIVATIVES

Bayer CropScience Aktieng...

1. A process for preparing a compound of formula (I),wherein:R3 is hydrogen;
each R6 is independently halogen or C1-C4-alkylsulfonyloxy; and
n is 0, 1, 2, or 3;
comprising reacting a compound of formula (II) or a salt thereof,
wherein:R3 is as defined for the compound of formula (I);
with a compound of formula (III),
wherein:R6 and n are as defined for the compound of formula (I); and
X is halogen;
in the presence of an acid to form the compound of formula (I).

US Pat. No. 10,336,741

SUBSTITUTED PYRROLIDINES AS FACTOR XIA INHIBITORS FOR THE TREATMENT THROMBOEMBOLIC DISEASES

ONO PHARMACEUTICAL CO., L...

1. A compound represented by formula (I):
wherein Cyc A represents cyclohexyl, phenyl, piperidinyl, piperazinyl, or indole;
Cyc B represents phenyl;
Cyc C represents pyrrolidinyl, piperidinyl, piperazinyl, or morpholinyl;
each R1 may be the same or different and represents (1) —C(?NH)NH2, (2) 5- to 10-membered heteroaryl, (3) C6-C10 aryl or 5- to 10-membered heteroaryl substituted with 1 to 5 groups selected from halogen, C1-4 alkyl, C1-4 alkoxy, —C1-4 alkylene-C1-4 alkoxy, CN, —COOH, —COO—C1-4 alkyl, —CO—NH2, —OCONH2, —OCONH-C1-4 alkyl, —CONH-C1-4 alkyl, —NHCOO—C1-4 alkyl and —NHCO—C1-4 alkyl, (4) C6-C10 aryl, (5) —NH—C(?NH)NH2, (6) C1-4 alkyl, (7) C2-4 alkenyl, (8) C2-4 alkynyl, (9) —C1-4 alkylene-NH2, (10) C1-4 alkoxy, (11) CN, (12) —CO—C1-4 alkyl, (13) halogen or (14) —R10—C(?NR11)NR12R13;
wherein R10 represents (1) a bond or (2) NH;
R11, R12 and R13 each independently represents (1) hydrogen, (2) OH, (3) C1-4 alkyl, (4) C2-4 alkenyl, (5) C2-4 alkynyl, (6) C1-4 alkoxy, (7) —C1-4 alkylene-C1-4 alkoxy, (8) —CO—C1-4 alkyl, (9) —COO—C1-4 alkyl, (10) —OCO—C1-4 alkyl, (11) —CO—R14, (12) —COO—R15 or (13) —OCO—R16, with the proviso that R11, R12 and R13 do not all simultaneously represent hydrogen;
wherein R14, R15 and R16 each independently represents C1-4 alkyl, C2-4 alkenyl or C2-4 alkynyl, which are substituted with 1 to 5 groups selected from C1-4 alkyl, C2-4 alkenyl, C2-4 alkynyl, halogen, trifluoromethyl, OH, —COO—C1-4 alkyl, COOH, oxo, C1-4 alkoxy, C6-C10 aryl, 5- to 10-membered heteroaryl and NR17R18;
wherein R17 and R18 each independently represents (1) hydrogen, (2) C1-4 alkyl, (3) C2-4 alkenyl or (4) C2-4 alkynyl;
t represents an integer of 0 to 6;
each R2 may be the same or different and represents (1) —COOH, (2) —COO—C1-4 alkyl, (3) —COO—C1-4 alkylene-C1-4 alkoxy, (4) —NH2, (5) —NH—C1-4 alkyl, (6) —NH—C1-4 alkylene-C1-4 alkoxy, (7) —NHCO—C1-4 alkyl, (8) —NHCO—C1-4 alkylene-C1-4 alkoxy, (9) —NHCOO—C1-4 alkyl, (10) —NHCOO—C1-4 alkylene-C1-4 alkoxy, (11) —CONH2, (12) —CONH—C1-4 alkyl, (13) —CONH—C2-4 alkylene-C1-4 alkoxy, (14) halogen, (15) —SO2—C1-4 alkyl, (16) oxo, (17) C1-4 alkoxy, (18) —CO—C1-4 alkyl, (19) —CO—C1-4 alkylene-C1-4 alkoxy or (20) —COO— C1-4 alkyl substituted with 1 to 5 groups selected from C1-4 alkyl, C2-4 alkenyl, C2-4 alkynyl, halogen, trifluoromethyl, OH, —COO—C1-4 alkyl, COOH, oxo, C1-4 alkoxy, C6-C10 aryl, 5- to 10-membered heteroaryl and NR19R20;
wherein R19 and R20 each independently represents (1) hydrogen, (2) C1-4 alkyl, (3) C2-4 alkenyl or (4) C2-4 alkynyl;
m represents an integer of 0 to 6;
each R3 may be the same or different and represents (1) —SO2—R6-R7, (2) oxo, (3) —CO—C1-4 alkyl, (4) —CO—NH2, (5) —SO2—NH2 or (6) —COO—C1-4 alkyl;
n represents an integer of 0 to 6;
R6 represents (1) a bond or (2) NH;
R7 represents (1) C1-4 alkyl, (2) Cyc D or (3) C1-4 alkyl or Cyc D substituted with 1 to 5 R8;
wherein Cyc D represents C3-C8 cycloalkyl, 5- to 10-membered heterocycloalkyl, C6-C10 aryl or 5- to 10-membered heteroaryl;
each R8 may be the same or different and represents (1) —COOH, (2) —COO—C1-4 alkyl, (3) —COO—C1-4 alkylene-C1-4 alkoxy, (4) —NH2, (5) —NH—C1-4 alkyl, (6) —NHCO—C1-4 alkyl, (8) —CONH2, (12) —CONH—C1-4 alkyl (13) OH or (14) halogen;
R4 represents (1) a bond, (2) C1-4 alkylene, (3) C2-4 alkenylene or (4) C2-4 alkynylene;
R5 represents (1) —CONH—, (2) Cyc E or (3) Cyc E substituted with 1 to 5 R9;
wherein Cyc E represents C3-C8 cycloalkyl, 5- to 10-membered heterocycloalkyl, C6-C10 aryl or 5- to 10-membered heteroaryl; and
each R9 may be the same or different and represents C1-4 alkyl or halogen;
a salt thereof, an N-oxide thereof, a solvate thereof, or a prodrug thereof.

US Pat. No. 10,336,739

4-HYDROXY-3-(HETEROARYL)PYRIDINE-2-ONE APJ AGONISTS

Bristol-Myers Squibb Comp...

1. A compound having the structure:
or a stereoisomer, a tautomer, or a pharmaceutically acceptable salt thereof.

US Pat. No. 10,336,737

METAL CATALYZED DEAROMATIVE 1,2-CARBOAMINATION

The Board of Trustees of ...

1. An urazole compound of Formula I:or the enantiomer thereof;wherein
R1 is alkyl, alkenyl, aryl, or heteroaryl;
R2, R3 and R6 are each independently H, D, halo, alkyl, cycloalkyl, ORA, N(RA)2, aryl, heteroaryl, or R2 and R3 taken together form a ring wherein the ring is unsaturated or aromatic;
R4 is H, alkyl, or cycloalkyl;
R5 is H, alkyl, cycloalkyl, or aryl;
each RA is independently H, alkyl, cycloalkyl, C(?O)RB, aryl, or heteroaryl; and
each RB is independently H, OH, halo, alkyl, aryl, heteroaryl, or N(RA)2, wherein N(RA)2 is not recursive with C(?O)RB;
wherein each alkyl, cycloalkyl, alkenyl, aryl, and heteroaryl is optionally substituted with one or more substituents.

US Pat. No. 10,336,736

MODULATORS OF CHEMOKINE RECEPTORS

ChemoCentryx, Inc., Moun...

1. A method of treating a CXCR2- and/or CCR6-mediated disease or condition in a subject in need thereof, said method comprising administering an effective amount of a compound of formula (A1) to said subject,
wherein
R1a is selected from CH3 and Cl;
R1b is H or is CH3;
R3 is H or D;
R4 is H, C1-8 alkyl, OH, —NRaRb, —C1-4 alkoxy, and Y; wherein the C1-8 alkyl is optionally substituted with halogen, —CN, —CO2Ra, —CONRaRb, —C(O)Ra, OC(O)NRaRb, —NRaC(O)Rb, —NRaC(O)2Rc, —NRaC(O)NRaRb, —NRaRb, —ORa, —S(O)2NRaRb, —NRaS(O)2Rb and Y, wherein Y is a 4 to 8 membered cycloheteroalkyl group or a 3 to 8 membered cycloalkyl group or a 5- or 6-membered aryl or heteroaryl group any of which is optionally substituted with from 1 to four substituents selected from halogen, oxo, —CN, —C1-6 alkyl, —C1-6 alkoxy, —C1-6 hydroxyalkyl, —C1-6 haloalkyl, O— C1-6 haloalkyl, —C1-4alkyl-O—C1-4 alkyl, —C1-6 alkyl-NRaRb, —C1-6 alkyl-CO2H, —C1-6 alkyl-CO2Ra, —C1-6 alkyl-CONRaRb, —C1-6 alkyl-C(O)Ra, —C1-6 alkyl-OC(O)NRaRb, —C1-6 alkyl-NRaC(O)Rb, —C1-6 alkyl-NRaC(O)2Rc, —C1-6 alkyl-NRaC(O)NRaRb, —C1-6 alkyl-ORa, —C1-6 alkyl-S(O)2NRaRb, —C1-6 alkyl-NRaS(O)2Rb, —CO2Ra, —CONRaRb, —C(O)Ra, —OC(O)NRaRb, —NRaC(O)Rb, —NRaC(O)2Rc, —NRaC(O)NRaRb, —NRaRb, —ORa, —S(O)2NRaRb, —NRaS(O)2Rb, —CH2CO2Ra; each Ra and Rb is independently selected from hydrogen, C1-4 alkyl, C1-4 hydroxyalkyl and C1-4 haloalkyl, and Rc is selected from C1-4 alkyl, C1-4 hydroxyalkyl and C1-4 haloalkyl; and wherein the 4 to 8 membered cycloheteroalkyl group and the 3 to 8 membered cycloalkyl group may additionally be optionally substituted with oxo;
R5a and R5b are each independently selected from H, F, Cl, Br and CH3;
R6a and R6b are each members independently selected from the group consisting of H, C1-4 alkyl, C1-4 hydroxyalkyl and C1-4 haloalkyl; or optionally R6a and R6b are taken together to form oxo (?O) or a 4 to 6 membered cycloheteroalkyl group or a 3 to 6 membered cycloalkyl group; and
R7 is methyl or ethyl; or a pharmaceutically acceptable salt, solvate or hydrate thereof.

US Pat. No. 10,336,735

SMALL MOLECULE INHIBITORS OF FIBROSIS

THE SCRIPPS RESEARCH INST...

1. A compound of Formula (I) or Formula (Ia):
wherein:
R1 is —CH(CH3)CH2CH2CH3 or —CH(CH2CH3)2;
R5 is H, —CN, halogen, haloalkyl, alkyl, —NR13R14, -alkylene(NR13R14), and —SO2R13;
each R8 is independently selected from halogen, —OH, —NO2, —N3, —CN, alkyl, alkoxy, haloalkoxy, haloalkyl, hydroxyalkyl, alkoxyalkyl, -alkylene(NR13R14), -alkylene(cycloalkyl), -alkylene(heterocyclyl), cycloalkyl, heterocyclyl, aryl, heteroaryl, —SR13, —SOR13, —SO2R13, —SO2NR13R14, —NR13R14, —NR13SO2R14, —NR13C(O)R14, —NR13C(O)OR14, —NR13C(O)NR13R14, —C(O)R14, —C(O)OR14, and —C(O)NR13R14; or two adjacent R8 form a heterocyclyl ring;
each R13 and each R14 is each independently selected from H, alkyl, cycloalkyl, heterocyclylalkyl, haloalkyl, hydroxyalkyl, alkoxyalkyl, arylalkyl, heteroarylalkyl, aryl, and heteroaryl; or R13 and R14 taken together form a heterocycle with the atoms to which they are attached; and
n is selected from 0, 1, 2, 3, and 4;
or a pharmaceutically acceptable salt, pharmaceutically acceptable solvate, or pharmaceutically acceptable prodrug thereof.

US Pat. No. 10,336,732

1-HETEROCYCLYL ISOCHROMANYL COMPOUNDS AND ANALOGS FOR TREATING CNS DISORDERS

Sunovion Pharmaceuticals ...

1. A method for treating a neurological or psychiatric disorder in a patient, wherein the disorder is major depression, schizophrenia, bipolar disorder, obsessive compulsive disorder (OCD), panic disorder, posttraumatic stress disorder (PTSD), mania, or psychosis, comprising administering to said patient an effective amount of a compound of formula:
or a pharmaceutically acceptable salt thereof, wherein:
m is 0, 1, or 2;
R is —H or C1-C3 alkyl;
Ra is —H or C1-C3 alkyl;
R1, R2, R3, and R4 are independently —H, halo, —OH, —NH2, C1-C3 alkyl, —OR7, —NHR7, —N(R7)R7, —CN, phenyl, or 5- or 6-membered heteroaryl, wherein:
each instance of R7 independently is unsubstituted C1-C2 alkyl or C1-C2 alkyl substituted with 1-3 halo,
each instance of C1-C3 alkyl independently is unsubstituted or substituted with 1-3 halo, and
the phenyl or heteroaryl is unsubstituted or substituted with 1 or 2 groups independently selected from halo, —OH, —OCH3, —OCF3, —NH2, —NH(CH3), —N(CH3)2, —CH3, ethyl, —CF3, and —CN,
optionally wherein
two adjacent instances of R1, R2, R3, and R4 together form —O—CH2—O—, —O—CH(CH3)—O—, —O—C(CH3)2—O—, —O—CH2—CH2—O—, or —O—C(CH3)2—C(CH3)2—O—;
each instance of R5 independently is halo, —CH3, or ethyl;
each instance of R6 independently is halo, —CH3, ethyl or —OH;
w is 0, 1, or 2; and
provided that the compound is not:

US Pat. No. 10,336,730

SUBSTITUTED GLYCINE DERIVED FXIA INHIBITORS

Bristol-Myers Squibb Comp...

8. A pharmaceutical composition comprising one or more compounds according to claim 1 and a pharmaceutically acceptable carrier or diluent.

US Pat. No. 10,336,728

SALTS OF A PIM KINASE INHIBITOR

Incyte Corporation, Wilm...

1. A solid form of a compound having the formula:wherein the solid form is crystalline having Form I.

US Pat. No. 10,336,726

3-METHYL-PYRROLIDINE-2,5-DIONE DERIVATIVES USEFUL AS CGRP RECEPTOR ANTAGONISTS

Eli Lilly and Company, I...

14. A pharmaceutical composition, comprising a compound or salt, or hydrate thereof, according to claim 1 with one or more pharmaceutically acceptable carriers, diluents, or excipients.

US Pat. No. 10,336,724

D-AMINO ACID OXIDASE INHIBITORS AND THERAPEUTIC USES THEREOF

SyneuRx International (Ta...

1. A compound of Formula (I):
or a pharmaceutically acceptable salt thereof, wherein:
the moiety

the moiety

 is bonded to E;
X is aryl;
Y is a five-membered heteroaryl with 1-2 ring heteroatoms selected from the group consisting of nitrogen and oxygen;
Z is aryl;
L1 is CH2 or C2-10 alkyl;
L2 is CH2, C2-10 alkyl, —CH2S—, or absent;
provided that when L2 is present, L2 is bonded to B or C, and when L2 is absent, Z is aryl fused with BC.

US Pat. No. 10,336,720

CYCLIC CARBONATE MONOMER CONTAINING DOUBLE IODINE, BIODEGRADABLE POLYMER PREPARED THEREBY AND USE

SOOCHOW UNIVERSITY, Suzh...

1. A biodegradable polymer containing a functional group of double iodine in the side chain, which includes cyclic carbonate monomer containing double iodine, wherein the biodegradable polymer containing a functional group of double iodine is polymerized of cyclic carbonate monomer containing double iodine by one of the following steps:(1) homopolymerize by cyclic carbonate monomer containing double iodine; or
(2) cyclic carbonate monomer containing double iodine has copolymerization with cyclic carbonate containing double sulfur or trimethylene cyclic carbonate;
said cyclic carbonate monomer containing double iodine is

the molecular weight of said biodegradable polymer containing a functional group of double iodine in the side chain is 3-500 kDa;
said biodegradable polymer containing a functional group of double iodine in the side chain has a polydispersity index (PDI) of 1.30 to 1.53; and
said biodegradable polymer containing a functional group of double iodine in the side chain forms nano-vesicles after dialysis.

US Pat. No. 10,336,719

1-(CYCLOPENT-2-EN-1-YL)-3-(2-HYDROXY-3-(ARYLSULFONYL)PHENYL)UREA DERIVATIVES AS CXCR2 INHIBITORS

GlaxoSmithKline Intellect...

1. A method of treating a disease or condition selected from the group consisting of: cancer, autoimmune or inflammatory diseases, neurodegenerative diseases, chronic obstructive pulmonary disease (COPD), chemotherapy induced peripheral neuropathy (CIPN), traumatic brain injury and spinal chord injury in a human in need thereof, the method comprising administering to the human a compound of formula (I) or a pharmaceutically acceptable salt thereof,whereinR1 is H, C1-3alkyl, C1-3haloalkyl or halo;
R2 is H, C1-3alkyl, C1-3haloalkyl or halo;
R3 is fluoro, chloro or cyano; and
R4 is selected from the group consisting of:
a) C1-6alkyl optionally substituted by one or more substituents independently selected from the group consisting of: fluoro, C1-3alkoxy, C1-3fluoroalkyl, C1-3fluoroalkoxy and hydroxy;
b) —(CH2)n—(R4a)(R4b); wherein
n is 0, 1 or 2;
the —(CH2)n— linker is optionally substituted by one or more groups independently selected from fluoro and methyl optionally substituted by one or more deuterium; and
wherein R4aand R4b are independently C1-3alkyl, or R4a and R4b may, together with the nitrogen to which they are attached, form a 4, 5 or 6-membered ring, which ring
i) optionally contains one additional ring-heteroatom selected from nitrogen and oxygen;
ii) may be saturated, or when the ring is a 5 or 6-membered, be unsaturated or aromatic;
iii) is optionally substituted by one or more substituents independently selected from C1-3alkyl optionally substituted by one or more substituents independently selected from the group consisting of deuterium, fluoro, C1-3fluoroalkyl, hydroxy, C1-3alkoxy, C1-3alkoxyC1-3alkyl and C1-3fluoroalkoxy; or
iv) is ortho-fused to a further 5 or 6-membered ring which further ring is saturated, unsaturated or aromatic; which further ring optionally contains one additional ring-heteroatom selected from nitrogen and oxygen; and which further ring is optionally independently substituted by one or more fluoro or methyl substituents;
c) —(CH2)p-heteroaryl; wherein
p is 1 or 2;
the —(CH2)p— linker is optionally substituted by one or more groups independently selected from fluoro and methyl optionally substituted by one or more deuterium;
the heteroaryl is 5 or 6-membered and is attached to the —(CH2)p— via a ring carbon atom; and
wherein the heteroaryl is optionally substituted by one or more substituents independently selected from the group consisting of C1-3alkyl, fluoro, C1-3fluoroalkyl; C1-3alkoxy, C1-3alkoxyC1-3alkyl and C1-3fluoroalkoxy; or wherein two substituents on adjacent ring-atoms, together with the interconnecting atoms form a further 5 or 6-membered ring ortho-fused to the heteroaryl group; which further ring is saturated, unsaturated or aromatic; and which further ring optionally contains one additional heteroatom selected from nitrogen and oxygen; and which further ring is optionally independently substituted by one or more fluoro or methyl substituents;
d) —(CH2)q-heterocyclyl; wherein
q is 0, 1 or 2;
the —(CH2)q— linker is optionally substituted by one or more groups independently selected from fluoro and methyl optionally substituted by one or more deuterium;
the heterocyclyl group is 3, 4, 5 or 6-membered and is attached to the —(CH2)q— via a ring carbon atom;
the heterocyclyl is saturated or unsaturated; and
wherein the heterocyclyl group is optionally substituted by one or more substituents independently selected from the group consisting of deuterium, C1-3alkyl optionally substituted by one or more deuterium, fluoro, C1-3fluoroalkyl, hydroxy, C1-3alkoxy, C1-3alkoxyC1-3alkyl, C1-3fluoroalkoxy, C3-6cycloalkyl and —(CH2)sNR4cR4d; or two substituents on the heterocyclyl group together with the interconnecting atom(s), form a further 5 or 6-membered ring which further ring is saturated, unsaturated or aromatic when the further ring is ortho-fused; and which further ring optionally contains one additional heteroatom selected from nitrogen and oxygen; and which further ring is optionally independently substituted by one or more fluoro or methyl substituents; wherein s is 0 or 1, and wherein R4c and R4dare independently C1-3alkyl, or R4c and R4d, together with the nitrogen to which they are attached, form a 4, 5 or 6-membered saturated ring which ring is optionally substituted by one or more fluoro substituent; and
e) —(CH2)r —C3-6cycloalkyl; wherein
r is 0, 1 or 2;
the —(CH2)r — linker is optionally substituted by one or more groups independently selected from fluoro and methyl optionally substituted by one or more deuterium; and
wherein the C3-6cycloalkyl group is optionally substituted by one or more substituents independently selected from the group consisting of C1-3alkyl optionally substituted by one or more deuterium, fluoro, C1-3fluoroalkyl, hydroxy, C1-3alkoxy, C1-3alkoxyC1-3alkyl, C1-3fluoroalkoxy and —(CH2)tNR4eR4f; or wherein two substituents on the cycloalkyl group together with the interconnecting atom(s) form a further 5 or 6-membered ring which further ring is saturated, unsaturated or aromatic when the further ring is ortho-fused; and which further ring optionally contains one heteroatom selected from nitrogen and oxygen; and which further ring is optionally independently substituted by one or more fluoro or methyl substituents; wherein t is 0 or 1, and wherein R4e and R4f are independently C1-3alkyl, or R4e and R4f, together with the nitrogen to which they are attached, form a 4, 5 or 6-membered saturated ring which ring is optionally substituted by one or more fluoro substituent.

US Pat. No. 10,336,717

INHIBITORS OF BETA-SECRETASE

Vitae Pharmaceuticals, LL...

1. A compound represented by the following Structural Formula:
or a pharmaceutically acceptable salt thereof, wherein:
ring Het is a 5 membered monocyclic heterocycle;
X is —C(R3R4)—;
each R0 is independent selected from —H, ?O, ?S, ?NR15, (C1-C6)alkyl, halo(C1-C6)alkyl, —CN, —NO2,
halogen, —OR5, —NR6R7, —S(O)iR5, —S(O)iNR12R13, —NR11S(O)iR5, —C(?O)OR5, —OC(?O)O R5, —C(?S)OR5, —O(C?S)R5, —C(?O)NR12R13, —NR11C(?O)R5, —C(?S)NR12R13, —NR11C(?S)R5, —NR1(C?O)OR5, —O(C?O)NR12R13, —NR11(C?S)OR5, —O(C?S)NR12R13, —NR11(C?O)NR12R13, —NR11(C?S)NR12R13, —C(?S)R5, —C(?O)R5, (C3-C8)cycloalkyl, (C3-C8)cycloalkyl(C1-C3)alkyl, (C3-C9)heterocycloalkyl, (C3-C9)heterocycloalkyl(C1-C3)alkyl, aryl, aryl(C1-C6)alkyl, heteroaryl or heteroaryl(C1-C6)alkyl, each of the (C1-C6)alkyl, halo(C1-C6)alkyl, (C3-C8)cycloalkyl, (C3-C8)cycloalkyl(C1-C3)alkyl, (C3-C9)heterocycloalkyl, (C3-C9)heterocycloalkyl(C1-C3)alkyl, aryl, aryl(C1-C6)alkyl, heteroaryl or heteroaryl(C1-C6)alkyl group represented by R0 is optionally substituted with 1 to 5 substituents independently selected from the group consisting of -halogen, —CN, (C1-C6)alkyl, halo(C1-C6)alkyl, (C1-C3)alkoxy, halo(C1-C3)alkoxy, (C1-C3)alkoxy(C1-C3)alkyl, (C3-C8)cycloalkyl, (C3-C9)heterocycloalkyl, aryl,
heteroaryl, —NR6R7, —NR11S(O)iR5, —C(?O)NR12R13, —NR11C(?O)R5, —S(O)iR5, —S(O)iNR12R13, —OR5, —C(?O)R5, —C(?S)NR12R13, —NR11C(?S)R5, —C(O)OR5, —OC(?O)OR5, —C(?S) OR5, —O(C?S)R5, —O(C?O)NR12R13, —NR11(C?O)OR5, —NR11(C?S)OR5, —O(C?S)NR12R13 , —NR11(C?O)NR12R13, —NR11(C?S)NR12R13 and —C(?S)R5, wherein the cycloalkyl, heterocycloalkyl, aryl and heteroaryl groups in the substituents on the groups represented by R0 are each optionally substituted with 1 to 3 substituents independently selected from halogen, —CN, (C1-C6)alkyl, halo(C1-C6)alkyl, (C1-C3)alkoxy, halo(C1-C3)alkoxy and (C1-C3)alkoxy(C1-C6)alkyl;
R1 is —H or —C(?O)(C1-C3)alkyl;
R2 is —H, halogen, —CN, —OR5, —C(?O)NR12R13, —C(?O)OR5, —C(O)R5, (C1-C6)alkyl, (C2-C6)alkenyl, (C2-C6)alkynyl, (C3-C6)cycloalkyl, (C3-C6)cycloalkyl(C1-C3)alkyl, (C4-C6)cycloalkenyl, phenyl, phenyl(C1-C3)alkyl, heteroaryl, heteroaryl(C1-C3)alkyl, (C5-C6)heterocycloalkyl, (C5-C6)heterocycloalky(C1-C3)alkyl, wherein the heteroaryl is selected from pyridyl, pyridazinyl, pyridinonyl, pyridazinonyl, thiazolyl, oxazolyl, oxadiazolyl, pyrazinyl, pyrimidyl, indolyl, quinolyl, quinoxalinyl, triazole and thiophenyl, the heterocycloalkyl is selected from oxetanyl, tretrahydrafuran, tetrapyran, piperidine, pyrrolidinyl and pyrrolidinonyl, and each of (C1-C6)alkyl, (C2-C6)alkenyl, (C2-C6)alkynyl, (C3-C6)cycloalkyl, (C3-C6)cycloalkyl(C1-C3)alkyl, (C4-C6)cycloalkenyl, phenyl, phenyl(C1-C3)alkyl, heteroaryl, heteroaryl(C1-C3)alkyl, (C5-C6)heterocycloalkyl and (C5-C6)heterocycloalky(C1-C3)alkyl groups represented by R2 is optionally substituted with 1 to 5 substituents independently selected from halogen, —CN, (C1-C3)alkyl, halo(C1-C3)alkyl, (C2-C6)alkynyl, —NR6R7, —S(O)iR5, —C(O)R5, —OH, (C3-C6)cycloalkyl, (C1-C3)alkoxy and halo(C1-C3)alkoxy;
R3 and R4 are each
independently —H, -halogen, —CN, —NO2, —OR5, —NR6R7, —S(O)iR5, —NR11S(O)iR5, —S(O)iN R12R13, —C(?O)OR5, —OC(?O)OR5, —C(?S)OR5, —O(C?S)R5, —C(?O)NR12R13, —NR11C(?O)R5, —C(?S)NR12R13, —NR11C(?S)R5, —NR11(C?O)OR5, —O(C?O)NR12R13, —NR11(C?S)O R5, —O(C?S)NR12R13, —NR11(C?O)NR12R13, —NR11(C?S)NR12R13, —C(?S)R5, —C(?O)R5, (C1-C6)alkyl, (C2-C6)alkenyl, (C2-C6)alkynyl, (C3-C8)cycloalkyl, (C3-C8)cycloalkyl(C1-C6)alkyl, (C3-C8)cycloalkyl(C2-C6)alkynyl, (C3-C9)heterocycloalkyl, (C3-C9)heterocycloalkyl(C1-C6)alkyl, (C3-C9)heterocycloalkyl(C2-C6)alkynyl, aryl, aryl(C1-C6)alkyl, aryl(C2-C6)alkynyl, heteroaryl, heteroaryl(C1-C6)alkyl or heteroaryl(C1-C6)alkynyl, wherein each (C1-C6)alkyl, (C2-C6)alkenyl, (C2-C6)alkynyl, (C3-C8)cycloalkyl, (C3-C8)cycloalkyl(C1-C6)alkyl, (C3-C8)cycloalkyl(C2-C6)alkynyl, (C3-C9)heterocycloalkyl, (C3-C9)heterocycloalkyl(C1-C6)alkyl, (C3-C9)heterocycloalkyl(C2-C6)alkynyl, aryl, aryl(C1-C6)alkyl, aryl(C2-C6)alkynyl, heteroaryl, heteroaryl(C1-C6)alkyl or heteroaryl(C1-C6)alkynyl represented by R3 and R4 is optionally substituted with 1 to 5 substituents independently selected from the group consisting of
halogen, —OR5, —NR6R7, —S(O)iR5, —NR11S(O)iR5, —S(O)iNR12R13, —C(?O)OR5, —OC(?O)O R5, —C(?S)OR5, —O(C?S)R5, —C(?O)NR12R13, —NR11C(?O)R5, —C(?S)NR12R13, —NR11C(?S)R5, —NR11(C?O)OR5, —O(C?O)NR12R13, —NR11(C?S)OR5, —O(C?S)NR12R13, —NR11(C?O)NR12R13, —NR11(C?S)NR12R13, —C(?S)R5, —C(?O)R5, (C1-C6)alkyl, (C2-C6)alkenyl, halo(C1-C6)alkyl, (C1-C3)alkylsulfonylaminoalkyl, hydroxy(C1-C6)alkyl, cyano(C1-C6)alkyl, (C1-C3)alkylcarbonylamino(C1-C6)alkyl, (C1-C3)alkoxy, halo(C1-C3)alkoxy, (C1-C6)alkoxy(C1-C3)alkyl, (C3-C5)cycloalkyl, (C3-C9)heterocycloalkyl, aryl and heteroaryl, wherein the cycloalkyl, heterocycloalkyl, aryl and heteroaryl groups in the substituents on the groups represented by R3 and R4 are each optionally substituted with 1 to 3 substituents independently selected from halogen, —CN, (C1-C6)alkyl, halo(C1-C6)alkyl, (C1-C3)alkoxy, halo(C1-C3)alkoxy and (C1-C3)alkoxy(C1-C6)alkyl;
R5 is selected from the group consisting of —H, (C1-C3)alkyl, halo(C1-C3)alkyl, (C1-C3)alkoxy(C1-C3)alkyl, (C3-C6)cycloalkyl, (C3-C6)cycloalkyl(C1-C3)alkyl, phenyl and phenyl(C1-C3)alkyl, wherein the phenyl group in the groups represented by R5 is optionally substituted with 1 to 3 substituents independently selected from ——F, —Cl, —Br, —CN, ?O, —NR6R7, (C1-C3)alkyl, halo(C1-C3)alkyl and (C1-C3)alkoxy(C1-C3)alkyl;
R6 is —H or (C1-C3)alkyl;
R7 is —H, (C1-C3)alkyl, halo(C1-C3)alkyl, (C3-C6)cycloalkyl, (C3-C6)cycloalkyl(C1-C3)alkyl or (C1-C3)alkoxy(C1-C3)alkyl;
R8 and R9 together with the carbon to which they are attached, form

R11 is —H or (C1-C3)alkyl;
R12 is —H or (C1-C3)alkyl; and
R13 is —H, (C1-C3)alkyl, halo(C1-C3)alkyl, (C3-C6)cycloalkyl(C1-C3)alkyl or (C1-C3)alkoxy(C1-C3)alkyl, or R12 and R13 together with the nitrogen atom to which they are attached forms a pyrrolidine or piperidine ring;
R14 is —H, —OR5, —NR6R7, (C1-C6)alkyl, (C3-C6)cycloalkyl, (C3-C6)cycloalkyl(C1-C3)alkyl, (C3-C5)heterocycloalkyl, (C3-C5)heterocycloalkyl(C1-C3)alkyl, heteroaryl, phenyl, phenyl(C1-C3)alkyl and heteroaryl(C1-C3)alkyl, wherein the heteroaryl is selected from pyridyl, pyridazinyl, pyridinonyl, pyridazinonyl, thiazolyl, oxazolyl, oxadiazolyl, pyrazinyl, pyrimidyl, indolyl, quinolyl, quinoxalinyl and thiophenyl and triazolyl, the (C3-C5)heterocycloalkyl is selected from oxetanyl, tetrahydrofuran, tetrahydropyran, piperidinyl and pyrrolidinyl, and each of the (C1-C6)alkyl, (C3-C6)cycloalkyl, (C3-C6)cycloalkyl(C1-C3)alkyl, (C3-C5)heterocycloalkyl, (C3-C5)heterocycloalkyl(C1-C3)alkyl, heteroaryl, phenyl, phenyl(C1-C3)alkyl and heteroaryl(C1-C3)alkyl groups represented by R14 is optionally substituted with 1 to 3 substituents independently selected from halogen, (C1-C6)alkyl, halo(C1-C6)alkyl, (C1-C3)alkoxy, —NR6R7, —S(O)iR5, —NR11SO2R5, —OH, —COOR5, —C(?O)R5, —C(?O)NR12R13 and thiazolyl;
R15 is —H or (C1-C6)alkyl optionally substituted with 1 to 5 —F;
R19 and R20 are each independently selected from —H,
halogen, —CN, —OR5, —NR6R7, —S(O)iR5, —NR11S(?O)iR5, —C(?O)OR5, —C(?O)NR12R13, —NR11C(?O)R5, —C(?S)NR12R13, —C(?O)R5, (C1-C6)alkyl, (C2-C6)alkenyl, aryl, aryl(C1-C6)alkyl, heteroaryl and heteroaryl(C1-C6)alkyl, wherein each of the (C1-C6)alkyl, (C2-C6)alkenyl, aryl, aryl(C1-C6)alkyl, heteroaryl and heteroaryl(C1-C6)alkyl groups represented by R19 and R20 is optionally substituted with 1 to 5 substituents independently selected from the group consisting of halogen, —CN, —OH, —NR11SO2(C1-C3)alkyl, —NR11C(?O)—(C1-C3)alkyl, (C1-C6)alkyl, halo(C1-C6)alkyl, (C1-C3)alkoxy, halo(C1-C3)alkoxy and (C1-C3)alkoxy(C1-C6)alkyl;
i is 0, 1 or 2;
p is 1, 2 3 or 4; and
q is 1, 2 or 3.

US Pat. No. 10,336,713

TRIAZOLE-BASED READER MOLECULES AND METHODS FOR SYNTHESIZING AND USE THEREOF

Arizona Board of Regents,...

1. A universal reader molecule for functionalization onto electrodes of a recognition tunneling molecule identification system comprising a triazole carboxamide compound of 5-(2-mercaptoethyl)-4H-1,2,4-triazole-3-carboxamide and its tautomers.

US Pat. No. 10,336,709

LP-PLA2 INHIBITORS

ABIDE THERAPEUTICS, INC, ...

1. A compound having the structure of Formula (I), or a pharmaceutically acceptable salt or solvate thereof:wherein:R1 is selected from the group consisting of —N(R10)R11, —OH, C1-C6alkyl, and C1-C6alkoxy;
R2 is selected from the group consisting of hydrogen, halogen, —N(R12)R13, —CF3, C1-C6alkyl, and C1-C6alkoxy;
R3 is hydrogen or C1-C3alkyl;
R4 and R5 are each independently selected from the group consisting of hydrogen, C1-C6alkyl optionally substituted by one, two, or three groups independently selected from halogen, cyano, and hydroxyl, and —(C1-C6alkylene)-(phenyl) optionally substituted by one, two, or three groups independently selected from halogen, cyano, —CF3, —OH, C1-C6alkyl, and C1-C6alkoxy;
each R6 is independently selected from the group consisting of halogen, —N(R12)R13, —CF3, C1-C6alkyl, and C1-C6alkoxy;
R10 and R11 are each independently selected from the group consisting of hydrogen, and C1-C3alkyl; or R10 and R11 together with the nitrogen atom to which they are attached, form a 4-6 membered heterocyclic ring optionally substituted by C1-C6alkyl or —CO2H;
each R12 and R13 are each independently selected from the group consisting of hydrogen, and C1-C3alkyl;
n is 1 or 2; and
p is 0, 1, or 2.

US Pat. No. 10,336,708

IMIDAZOLE COMPOUND, METAL SURFACE TREATMENT LIQUID, METAL SURFACE TREATMENT METHOD, AND LAMINATE PRODUCTION METHOD

TOKYO OHKA KOGYO CO., LTD...

1. An imidazole compound represented by the following formula (1-1-1):wherein R1 represents a hydrogen atom or an alkyl group, R4 represents a halogen atom, a hydroxyl group, a mercapto group, a sulfide group, a silyl group, a silanol group, a nitro group, a nitroso group, a sulfonate group, a phosphino group, a phosphinyl group, a phosphonato group, or an organic group,at least one of R11, R12, R13, R14, and R15 is a group represented by —O—R10 wherein R10 is an alkyl group, and each remaining member of R11, R12, R13, R14, and R15 is a hydrogen atom, and
n represents an integer of 0 to 3.

US Pat. No. 10,336,705

ELECTRICALLY CONDUCTING OLIGO(PYRAZOLES)

The United States of Amer...

1. An electrically conducting organic oligomer comprising 4-nitro-1H-pyrazole-3-yl-amine, 4-trifluoromethyl-1H-pyrazol-3-yl-amine, 4-trichloromethyl-1H-pyrazol-3-yl-amine, 4-tribromomethyl-1H-pyrazol-3-yl-amine, 4-ammonium-1H-pyrazol-3-yl-amine, 4-trimethylammonium-1H-pyrazol-3-yl-amine, 4-triethylammonium-1H-pyrazol-3-yl-amine, or 4-tripropylammonium-1H-pyrazol-3-yl-amine.

US Pat. No. 10,336,704

METHOD FOR PREPARING INDENOISOQUINOLINE DERIVATIVES

NATIONAL TAIWAN NORMAL UN...

1. A method for preparing indenoisoquinoline derivatives represented by one of the following formulas (1) to (31), (34) to (39) and (41) to (46), comprising the following steps:
(A) providing a first reactant represented by the following formula (II) and a second reactant represented by the following formula (III):

wherein A is —OH or —NHR2;
X is —CO;
Y ring is a phenyl ring;
Z is F, Cl, Br or I;
n is an integral of 1 to 4;
each R1 independently is H, nitro, Br, Cl or methoxy; or when n is 2, two adjacent R1 and carbon atoms attached thereto together form a dioxolane; and
R2 is H, methyl, ethyl, propyl, pentyl, allyl, phenyl, benzyl, morpholinoethyl, morpholinopropyl, imidazolpropyl, methoxyethyl, methoxypropyl, phenylbutyl, 4-fluorophenyl, 4-chlorophenyl,
wherein * is a bonding position,
wherein m is an integral of 1 to 4; and
each R3 independently is H, Br, nitro or methoxy; or when m is 2, two adjacent R3 and carbon atoms attached thereto together form a dioxolane; and
(B) reacting the first reactant represented by the formula (II) and the second reactant represented by the formula (III) in a solvent with a catalyst and adding R2NH2 therein in the case where A is —OH, to obtain the indenoisoquinoline derivatives represented by one of the formulas (1) to (31), (34) to (39) and (41) to (46), wherein the catalyst comprises Cu+ or Cu2+.

US Pat. No. 10,336,702

PHARMACEUTICALLY ACTIVE COMPOUNDS

BerGenBio ASA, Bergen (N...

1. A compound of formula (I):
wherein
one of Q1 and Q2 represents a nitrogen atom and the other represents CH, or both Q1 and Q2 represent nitrogen atoms, and Q3 represents CH;
A represents an optionally substituted five- or six-membered aromatic ring;
R1 represents an aliphatic carbocyclic or heterocyclic ring, optionally substituted by —(C?O)xNRaRb, —ORc, —SO2Rg or optionally substituted alkyl, in which
x is 0 or 1;
Ra and Rb independently represent (a) H, (b) optionally substituted alkyl, (c) optionally substituted cycloalkyl, (d) optionally substituted heterocycloalkyl, (e) —(C?O)Rd, or (f) —SO2Re, wherein Rd and Re independently represent (i) optionally substituted alkyl, (ii) optionally substituted alkoxy, or (iii) optionally substituted cycloalkyl; or Ra and Rb together with the nitrogen atom to which they are attached form an optionally substituted aromatic or aliphatic heterocyclic ring;
Rc represents optionally substituted alkyl;
and
Rg represents optionally substituted cycloalkyl;
R2 represents H, optionally substituted alkyl or halo;
R3 represents an optionally substituted aryl or heteroaryl ring;
R5 and R6 independently represent H or optionally substituted alkyl; or R5 and R6 together with the carbon atom to which they are attached form an optionally substituted cycloalkyl ring, optionally containing a heteroatom;
and the corresponding N-oxides; and pharmaceutically acceptable salts and solvates of such compounds and their N-oxides and prodrugs.

US Pat. No. 10,336,701

PYRIDIN-2-ONE DERIVATIVES OF FORMULA (II) USEFUL AS EP3 RECEPTOR ANTAGONISTS

Janssen Pharmaceutica NV,...

1. A compound of formula (II)
wherein
is selected from the group consisting of naphth-2-yl, indol-5-yl, indazol-5-yl, indazol-6-yl, benzimidazol-5-yl, benzimidazol-6-yl, benzothiazol-5-yl, benzothiazol-6-yl, benzoisothiazol-6-yl, chroman-7-yl, chromen-7-yl, benzo[d][1,3]dioxol-5-yl, 3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl, 3,4-dihydro-2H-benzo[b][1,4]oxazin-7-yl and 2,3-dihydro-benzo[b][1,4]dioxin-6-yl;wherein the naphth-2-yl, indol-5-yl, indazol-5-yl, indazol-6-yl, benzimidazol-5-yl, benzimidazol-6-yl, benzothiazol-5-yl, benzothiazol-6-yl, benzoisothiazol-6-yl, chroman-7-yl, chromen-7-yl, benzo[d][1,3]dioxol-5-yl, 3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl, 3,4-dihydro-2H-benzo[b][1,4]oxazin-7-yl or 2,3-dihydro-benzo[b][1,4]dioxin-6-yl; is optionally substituted on the phenyl portion of the
bicycle with one to two substituents independently selected from the group consisting of halogen, oxo, cyano, C1-3alkyl, fluorinated C1-2alkyl, C1-3alkoxy, fluorinated C1-2alkoxy and C3-6cycloalkyl;and wherein the naphth-2-yl, indol-5-yl, indazol-5-yl, indazol-6-yl, benzimidazol-5-yl, benzimidazol-6-yl, benzothiazol-5-yl, benzothiazol-6-yl, benzoisothiazol-6-yl, chroman-7-yl, chromen-7-yl, benzo[d][1,3]dioxol-5-yl, 3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl, 3,4-dihydro-2H-benzo[b][1,4]oxazin-7-yl or 2,3-dihydro-benzo[b][1,4]dioxin-6-yl; is further optionally substituted on the
portion of thebicycle with one to two substituents independently selected from the group consisting of halogen, oxo, cyano, C1-3alkyl, fluorinated C1-2alkyl, C1-3alkoxy, fluorinated C1-2alkoxy and C3-6cycloalkyl;R3 is selected from the group consisting of hydrogen, halogen and C1-4alkyl;
R4 is selected from the group consisting of hydrogen, halogen and C1-4alkyl;
R5 is selected from the group consisting of hydrogen, fluoro, hydroxy, C1-4alkyl, C3-6cycloalkyl and —C(O)NRURV; wherein RU and RV are each independently selected from the group consisting of hydrogen and C1-2alkyl;
is a ring structure selected from the group consisting of cyclopentyl, cyclohexyl, azetidin-3-yl, pyrrolidin-3-yl, piperidin-3-yl, piperidin-4-yl, morpholin-2-yl, thiomorpholin-4-yl, tetrahydropyran-4-yl, 4,5,6,7-tetrahydro-2H-indazol-5-yl, 1,5-dihydro-imidazol-5-yl, 3,5-dihydro-imidazol-5-yl, 4,5-dihydro-imidazol-4-yl, 4,5-dihydro-imidazol-5-yl, imidazolidin-4-yl, imidazolidin-5-yl, 4,5-dihydro-pyrrol-3-yl, 4,5-dihydro-pyrazol-5-yl, 1,2,5-thiadiazolidin-3-yl, 4,5,6,7-tetrahydro-benzo[d]isoxazol-5-yl, imidazo[1,2-a]imdazol-3-yl, imidazo[2,1-c][1,2,4]triazol-5-yl, 6,7-dihydro-5H-imidazo[2,1-c][1,2,4]triazol-6-yl, tetrahydro-1H,3H-pyrrolo[1,2-c]oxazol-6-yl, 6-oxabicyclo[3.2.1]octan-5-yl, 8-azabicyclo[3.2.1]octan-3-yl, 6-azabicyclo[3.2.1]octan-4-yl, 1-oxa-3-azaspiro[4.5]decan-7-yl, 2-azaspiro[4.5]decan-8-yl, 1?2,3-diazaspiro[4.5]decan-7-yl, 2-azaspiro[5.5]undecan-9-yl, 3-azaspiro[5.5]undecan-9-yl, 1,3-diazaspiro[4.5]decan-8-yl and octahydro-cyclopenta[c]pyrrol-5-yl;wherein the
ring structure is optionally substituted with one or more substituents independently selected from the group consisting of C1-4alkyl, hydroxy, oxo, thioxo, cyano, —NRFRG, —NH(CN), ?NH, ?N(CN), ?N(OH), ?N(O—C1-2alkyl), —CH2—NRFRG—C(O)—NRFRG, —C(O)—NRFRG, —C(O)—CH2OH, —SO2—(C1-4alkyl), —NRF—SO2—(C1-4alkyl) and —C(NRFRG)(?N—CN);wherein RF and RG are each independently selected from the group consisting of hydrogen and C1-4alkyl;
provided that when R3 is hydrogen, R4 is hydrogen, R5 is selected from the group consisting of hydrogen, C1-4alkyl and C3-6cycloalkyl, and
is selected from the group consisting of pyrrolidin-3-yl-2-one and piperidin-3-yl-2-one, thenis other than indol-5-yl, indazol-5-yl, indazol-6-yl, benzimidazol-5-yl or benzimidazol-6-yl; wherein the indol-5-yl, indazol-5-yl, indazol-6-yl, benzimidazol-5-yl or benzimidazol-6-yl is optionally substituted with one or more substituents independently selected from the group consisting of halogen, C1-3alkyl and C3-6cycloalkyl;provided further that when
is selected from the group consisting of indol-5-yl, indazol-6-yl and benzimidazol-6-yl; wherein the indol-5-yl, indazol-6-yl or benzimidazol-6-yl is optionally substituted with one to two substituents independently selected from the group consisting of halogen and C1-3alkyl, R3 is hydrogen, R4 is hydrogen and R5 is methyl, thenis other than pyrrolidin-3-yl-2-one or piperidin-3-yl-2-one;provided further than when
is selected from the group consisting of naphth-2-yl and 8-fluoro-naphth-2-yl, R3 is selected from the group consisting of hydrogen, halogen and C1-3alkyl, R4 is hydrogen and R5 is selected from the group consisting of hydrogen, C1-4alkyl and C3-6cycloalkyl, thenis other than imidazolidin-4-yl-2-one;or a tautomer or a pharmaceutically acceptable salt thereof.

US Pat. No. 10,336,643

GLASS SHAPING APPARATUS AND METHODS

CORNING INCORPORATED, Co...

1. A glass shaping apparatus comprising:a plurality of rib members, one or more rib members comprising at least one void and at least one shaping edge;
at least one guide member connected to at least one rib member, said at least one guide member comprising at least one shaping edge substantially matching a shape or a curvature of the shaping edge of the at least one rib member;
at least one support member connecting at least two members of the plurality of rib members and at least one guide member; and
a shaping member proximate one or more of the shaping edges of the rib members, the shaping member having at least one first curvature that substantially matches at least one first curvature of the shaping edges,
wherein at least one shaping edge of at least one rib member and at least one shaping edge of at least one guide member are configured to define a shaping groove, and
wherein the shaping member is disposed in or otherwise affixed to the shaping groove.

US Pat. No. 10,336,642

METHOD FOR MANUFACTURING FORMED GLASS AND HEATING APPARATUS

AGC Inc., Chiyoda-ku (JP...

1. A method for manufacturing a formed glass, the method comprising:heating a glass substrate; and
forming the glass substrate into a desired shape,
wherein the heating of the glass substrate comprises:
applying an electric current to a heating element to heat a heating reservoir having a transmittance of 50% or more in a wavelength of 0.5 ?m to 2.5 ?m by heat from the heating element;
placing the glass substrate such that the heat reservoir is positioned between the heating element and the glass substrate;
heating a glass substrate by heat from the heating reservoir without applying the electric current to the heating element,
subsequently applying the electric current to the heating element to heat the glass substrate by heat from the heating element and from the heating reservoir.

US Pat. No. 10,336,641

METHOD FOR PRODUCING A FOAM GLASS WITH HIGH OPEN PORE CONTENT

Ngee Ann Polytechnic, Si...

1. A method for producing foam glass comprising the steps of:combining glass particles with foaming agents, additives and a binding agent to form a mixture;
compressing the mixture in a mold with a compression pressure between 2 MPa and 20 MPa for a period of time between 30 seconds and 15 minutes to form a compressed sample;
de-molding the sample and curing the sample;
heating the sample to a first elevated temperature and maintaining the sample at the first elevated temperature for a first period of time to decompose a part of the foaming agents;
heating the sample from the first elevated temperature to a second elevated temperature and maintaining the sample at the second elevated temperature for a second period of time to decompose the remainder of the foaming agents;
cooling the sample from the second elevated temperature to a first lowered temperature for a third period of time to anneal the sample; and
cooling the sample from the first lowered temperature to an ambient room temperature, the cooled sample having open pore content between 88% and 95%, compression strength between 2.1 MPa and 2.8 MPa, and bulk densities between 0.17 g cm?3 and 0.22 g cm?3.

US Pat. No. 10,336,640

METHOD AND APPARATUS FOR MELTING SOLID RAW BATCH MATERIAL USING SUBMERGED COMBUSTION BURNERS

1. A process of providing a molten material comprising introducing solid batch material into a melter, and melting the solid batch material in the melter by submerged combustion to afford a melt, and subjecting the melt to a flow pattern which when simulated by means of Computational Fluid Dynamics analysis shows a substantially toroidal melt flow pattern generated in the melt in the melter, comprising major centrally inwardly convergent flow vectors at the melt surface followed by downward oriented flow in proximity of the central axis of revolution of the toroidal melt flow pattern, with the central axis of revolution of the toroidal melt flow pattern being substantially vertical.

US Pat. No. 10,336,637

CLOSED-LOOP BIOREGENERATIVE WATER PURIFICATION SYSTEM FOR THE INTERNATIONAL SPACE STATION (ISS) AND FOR SUSTAINABLE MARS EXPLORATION

The United States of Amer...

1. A water purification system, comprising:a bioreaction subsystem comprising:
an input receiving contaminated input effluent;
a gas-lift anaerobic membrane bioreactor that removes at least one of urea and organic matter from the input effluent to create a first effluent; and
a bioreaction output through which passes the first effluent;
a light-treatment subsystem comprising:
an input fluidically connected to the bioreaction output and receiving the first effluent;
an ultraviolet (UV) light exposing the first effluent to UV light to create a second effluent substantially free from microorganisms; and
a UV output through which passes the second effluent;
a reactor subsystem comprising:
an ammonia-reducing reactor comprising:
an input fluidically connected to the UV output and receiving the UV-treated second effluent; and
a reactor output; and
a struvite regenerator fluidically connected to the reactor output, separating ammonia from the second effluent in the ammonia-reducing reactor, and outputting the ammonia; and
a separation subsystem comprising:
an input fluidically connected to the reactor output and receiving the second effluent substantially free from ammonia;
a continuous electro-deionization device separating brine/salts from the second effluent to produce potable water; and
having a potable water output.

US Pat. No. 10,336,635

SUBSURFACE SEWAGE DISPOSAL SYSTEM

1. A subsurface sewage disposal system comprising:a plurality of leaching members oriented substantially vertically and positioned in a non-linear arrangement;
a first volume defined within each of the plurality of leaching members and forming a void therein, the first volume having a permeable enclosure configured to provide temporary storage of an effluent therein;
a distribution pipe configured to introduce the effluent into the plurality of leaching members; and
a plurality of balancing pipes configured in a non-linear arrangement to redistribute the effluent introduced into at least one of the plurality of leaching members into at least one other of the plurality of leaching members;
wherein:
as the effluent rises within at least one of the plurality of leaching members, the effluent is redistributed by at least one of the plurality of balancing pipes to at least one other of the plurality of leaching members; and
in the event of a failure of the distribution pipe, the plurality of balancing pipes is configured to bypass the distribution pipe and redistribute the effluent to the plurality of leaching members downstream of such failure.

US Pat. No. 10,336,634

FINE BUBBLE DIFFUSER ASSEMBLY

1. A diffuser assembly comprising:a flexible diffuser membrane defining a circumferential bead; and
a diffuser body defining a circular plate underlying the flexible diffuser membrane and defining an edge ring covering a covered portion of the circumferential bead such that the circumferential bead cannot be lifted away from the diffuser body with the flexible diffuser membrane and the diffuser body intact;
wherein:
the edge ring is integral to the diffuser body with the edge ring and the remainder of the diffuser body formed from a continuous piece of the same plastic material.

US Pat. No. 10,336,628

CATALYTIC FAST PYROLYSIS PROCESS WITH IMPURITY REMOVAL

ANELLOTECH, INC., Pearl ...

1. An improved catalytic fast pyrolysis process comprising steps of:a) treating biomass containing alkali and alkaline earth metal components to reduce alkali and alkaline earth metal content to result in treated biomass,
b) feeding the treated biomass of step a), catalyst composition, and transport fluid to a catalytic fast pyrolysis process fluidized bed reactor maintained at reaction conditions to manufacture a raw fluid product stream,
c) feeding the raw fluid product stream of step b) to a solids separation and stripping system to produce separated solids and a fluid product stream,
d) feeding the fluid product stream of step c) to a vapor/liquid separation system to produce a liquid phase stream comprising water and components selected from the group consisting of char, coke, ash, catalyst fines, water soluble organics and heavy organics, and combinations thereof, and a vapor phase stream comprising benzene, toluene xylenes, olefins having carbon numbers of 2 to 4, methane, carbon monoxide, and carbon dioxide, and
e) feeding the vapor phase stream of step d) to a product recovery system to recover benzene, toluene, xylenes and, optionally, olefins.

US Pat. No. 10,336,623

METHOD FOR REVAMPING AN AMMONIA CONVERTER

Casale SA, Lugano (CH)

1. A method for revamping a multi-bed ammonia converter, wherein said converter comprises:a plurality of adiabatic catalytic beds including a first catalytic bed and one or more further catalytic bed(s) , said catalytic beds being arranged in series so that the effluent of a bed is further reacted in the subsequent bed;
at least a first inter-bed heat exchanger arranged between said first catalytic bed and a second catalytic bed to cool the effluent of said first bed before admission into said second bed, and optionally further inter-bed heat exchanger(s) arranged between consecutive beds;
wherein said first catalytic bed is converted into an isothermal catalytic bed.

US Pat. No. 10,336,619

METHOD FOR THE SYNTHESIS OF GRAPHENE OXIDE

Sri Lanka Institute of Na...

1. A method of synthesizing graphene oxide with an X-ray diffraction spectrum having a single dominant peak at a two theta angle below 10 degrees without the use of H3PO4 or a nitrogen-containing compound comprising:a. providing a graphite source;
b. reacting the graphite source with H2SO4 in a vessel;
c. adding KMnO4 to the vessel to form a reaction mixture, wherein the H2SO4, graphite source, and KMnO4 are maintained at a temperature between 0° C. and 10° C. from the addition of the H2SO4 through reaction with KMnO4 for a period of more than 8 hours;
d. adding H2O2 and H2O to the reaction mixture in order to create a supernatant and a graphene oxide slurry; and
e. separating the supernatant in order to obtain the graphene oxide slurry.

US Pat. No. 10,336,618

APPARATUS AND METHOD FOR SYNTHESIZING VERTICALLY ALIGNED CARBON NANOTUBES

The Florida International...

1. A method for synthesizing vertically aligned carbon nanotubes, the method comprising:providing a catalytic conductive substrate, that has not been pretreated, to a PECVD device;
heating, in an etching gas, the catalytic conductive substrate to form catalytically active nano-features on the surface of the catalytic conductive substrate; and
growing, by PECVD, vertically aligned carbon nanotubes on the surface of the catalytic conductive substrate, without an external metallic catalyst layer, by providing a carbon source gas to the catalytic conductive substrate,
the PECVD device comprising:
a tube;
a first metallic rod disposed inside the tube and having an anode disposed on an inner end thereof;
a second metallic rod disposed inside the tube and having a cathode disposed on an inner end thereof;
a substrate holder disposed on the cathode;
an external heating device surrounding the substrate holder;
a thermocouple device disposed inside the tube and configured to monitor a temperature and provide feedback to a power supply of the external heating device;
a gas inlet valve connected to a first end of the tube;
a gas outlet valve connected to the tube;
a heat reflector disposed inside the tube;
a gas distributor disposed inside the tube; and
a power supply electrically connected to the two metallic rods and configured to supply a desired bias voltage to generate plasma inside the tube,
a thickness of the external heating device in a first direction being larger than a distance, measured in the first direction, between the respective electrodes of the two metallic rods,
the anode having a first surface facing the gas inlet valve and a second surface opposite from the first surface,
the cathode having a first surface and a second surface opposite from the first surface, the first surface of the cathode facing a second end of the tube opposite from the first end of the tube, and the second surface of the cathode facing the second surface of the anode and having the substrate holder disposed thereon,
the thermocouple device being disposed between the first surface of the anode and the first end of the tube, and
the heat reflector and the gas distributor both disposed between the thermocouple device and the first end of the tube, the heat reflector and the gas distributor both being disposed closer to the first end of the tube than they are to the thermocouple device.

US Pat. No. 10,336,617

METHOD OF SYNTHESIZING SOLUBLE POLYPHOSPHIDES FROM RED PHOSPHOROUS USING SHELF-STABLE REAGENTS AND ORGANIC SOLVENTS

The Florida State Univers...

1. A method for producing polyphosphide anions soluble in organic solvents, comprising:providing red phosphorus or a composition of black phosphorus and red phosphorus;
providing an alkali metal alkoxy compound or alkali metal alkyl thiolate compound suspended in an organic solvent;
wherein the alkali metal is sodium or potassium;
allowing the red phosphorus and alkali metal or alkali metal compound to react, wherein the reaction uses reflux or an in-line packed column method;
where the in-line packed column method comprises:
providing a packing column;
loading the packing column with the red phosphorus or composition of black phosphorus and red phosphorus in an inert environment;
purging the packing column with an inert gas;
setting a pressure regulator on the packing column to at least 1 bar;
heating the packing column to a preselected temperature, where the preselected temperature is at least the boiling point of the alkali metal alkoxy compound or alkali metal alkyl thiolate and wherein the temperature of the packing column or a reaction solution does not exceed the critical temperature of the organic solvent;
suspending the alkali metal alkoxy compound or alkali metal alkyl thiolate compound in the organic solvent;
flowing the organic solvent through the packing column;
flowing the alkali metal alkoxy compound or alkali metal alkyl thiolate compound in the organic solvent through the packing column;
forming a compound containing the alkali metal and polyphosphide anions;
evaporating the organic solvent off the compound containing the alkali metal and polyphosphide anions;
redissolving the compound containing the alkali metal and polyphosphide anions in ethanol;
subjecting the compounds containing alkali metal and polyphosphide anions to a cation exchange with (Bu4N)Cl in ethanol to produce a cation-polyphosphide material;
redissolving the cation-polyphosphide material in acetonitrile to form free polyphosphide anions; and
separating the black phosphorus from the polyphosphide anions;
wherein the reflux is performed for about 15 minutes to about 2 hours.

US Pat. No. 10,336,616

METHOD OF CONVERTING RED PHOSPHOROUS TO SOLUBLE POLYPHOSPHIDES USING POTASSIUM ETHOXIDE

The Florida State Univers...

1. A method for producing polyphosphide anions soluble in organic solvents, comprising:providing red phosphorus or a composition of black phosphorus and red phosphorus;
providing potassium ethoxide suspended in an organic solvent;
allowing the red phosphorus and the potassium ethoxide to react, wherein the reaction uses reflux or an in-line packed column method;
where the in-line packed column method comprises:
providing a packing column;
loading the packing column with the red phosphorus or composition of black phosphorus and red phosphorus in an inert environment;
purging the packing column with an inert gas;
setting a pressure regulator on the packing column to at least 1 bar;
heating the packing column to a preselected temperature, where the preselected temperature is at least the boiling point of the potassium ethoxide;
suspending the potassium ethoxide in the organic solvent;
flowing the organic solvent through the packing column;
flowing the potassium ethoxide in the organic solvent through the packing column; and
forming a compound containing potassium metal and polyphosphide anions.

US Pat. No. 10,336,615

TITANIUM LIGAND-MODIFIED BLACK PHOSPHORUS AND PREPARATION METHOD AND USE THEREOF

SHENZHEN INSTITUTES OF AD...

1. A titanium ligand-modified black phosphorus, which is a complex of black phosphorus and a titanium ligand having a structure represented by formula (I):
wherein in the formula (I), R1 comprises C1-C6 alkyl, or phenyl optionally further substituted with 0 to 5 groups each independently selected from halogen atom, C1-C6 alkyl, nitro, hydroxy, amino or C1-C3 alkoxy; the C1-C6 alkyl or C1-C3 alkoxy is optionally further substituted with 0 to 3 groups each independently selected from halogen atom, nitro, hydroxy, amino, methyl, ethyl or n-propyl.

US Pat. No. 10,336,610

METHOD FOR PRODUCING A MICROMECHANICAL COMPONENT

ROBERT BOSCH GMBH, Stutt...

1. A method for producing a micromechanical component, the micromechanical component including a substrate device and a cap device, the method comprising:in a preparatory step, pattering at least one of the substrate device and the cap device;
in a first sub-step, adjusting at least one of a first pressure and a first chemical composition, and connecting the substrate device and the cap device to each other in such a way that a first cavity is formed, which is sealed from an environment of the micromechanical component, at least one of the first pressure prevailing in the first cavity and the first chemical composition being enclosed;
in a second sub-step, adjusting at least one of a second pressure and a second chemical composition, connecting the substrate device and the cap device to each other in such a way that a second cavity is formed, which is sealed from the environment of the micromechanical component and from the first cavity, at least one of the second pressure prevailing in the second cavity and the second chemical composition being enclosed,
wherein the substrate device includes a first substrate frame and a second substrate frame, the first substrate frame and the second substrate frame are developed in such a way that prior to the first sub-step, an extension of the first substrate frame perpendicular to a substrate main-extension plane of the substrate device is greater than an extension of the second substrate frame perpendicular to the substrate main-extension plane.

US Pat. No. 10,336,609

MICROSTRUCTURE PROCESSING METHOD AND MICROSTRUCTURE PROCESSING APPARATUS

Hitachi, Ltd., Tokyo (JP...

1. A microstructure processing method comprising the steps of:(a) applying an ion beam to a workpiece to form a hole having a tapered shape in the workpiece without supplying an etching gas to the workpiece;
(b) stopping the application of the ion beam to the workpiece;
(c) while the ion beam is not applied to the workpiece and without supplying the etching gas to the workpiece, supplying a non-etching gas to the workpiece at an oblique angle to an upper surface of the workpiece to cause the gas molecules of the non-etching gas to be adsorbed onto the upper surface of the workpiece and a sidewall of the hole;
(d) stopping the supply of the non-etching gas to the workpiece; and
(e) while the non-etching gas is not supplied to the workpiece, applying the ion beam to the workpiece to perform film formation using the adsorbed gas molecules and to perform etching on the hole to increase an inclination of the sidewall,
wherein a processing shape of the workpiece is controlled by controlling a supply time of the non-etching gas.

US Pat. No. 10,336,607

MEMBRANE COMPONENTS AND METHOD FOR FORMING A MEMBRANE COMPONENT

INFINEON TECHNOLOGIES AG,...

1. A membrane component, comprising:a membrane structure comprising an electrically conductive membrane layer, wherein the electrically conductive membrane layer has a suspension region and a membrane region, wherein the suspension region of the electrically conductive membrane layer is arranged on an insulation layer, and wherein the insulation layer is arranged on a carrier substrate; and
a counterelectrode structure, wherein a cavity is arranged vertically between the counterelectrode structure and the membrane region of the electrically conductive membrane layer,
wherein an edge of the electrically conductive membrane layer projects laterally beyond an edge of the insulation layer by more than half of a vertical distance between the electrically conductive membrane layer and the counterelectrode structure, and wherein the electrically conductive membrane layer takes up more than 90% of forces which are exerted on the membrane structure when a deflection of the membrane region of the electrically conductive membrane layer deflects.

US Pat. No. 10,336,606

INTEGRATED CAPACITIVE HUMIDITY SENSOR

NXP USA, Inc., Austin, T...

1. A method for forming a semiconductor device, comprising:forming a first electrically conductive metal layer on a surface of an IC substrate;
electrografting a moisture-sensitive polymer layer onto the first electrically conductive metal layer;
forming a passivation layer over the substrate with the polymer layer exposed through one or more openings in the passivation layer;
wherein the polymer layer functions as a capacitive humidity sensing element when exposed to ambient air;
further comprising, prior to electrografting the polymer layer,
forming the first electrically conductive metal layer over an insulating layer on the substrate; and forming a patterned mask over the first electrically conductive metal layer;
wherein the polymer layer is electrographed onto an exposed area of the first electrically conductive metal layer;
further comprising, after electrografting the polymer layer, selectively removing the mask and conductive metal layer underlying the mask to expose the insulating layer on the substrate;
patterning the first electrically conductive metal layer to form an RDL layer comprising a contact area;
forming a passivation layer over the RDL layer;
forming an opening through the passivation layer to expose the contact area of the RDL layer;
forming a UBM structure on the contact area within the opening; and
forming a plurality of openings through the passivation layer and the RDL layer underlying the passivation layer to expose the polymer layer;
wherein the polymer layer functions as a capacitive humidity sensing element when exposed to ambient air;
further comprising, prior to electrografting the polymer layer,
forming the first electrically conductive metal layer over an insulating layer on the substrate; and
masking and patterning the first electrically conductive metal layer to form a pair of interdigitated sensing electrodes; and
forming a patterned photoresist mask over the substrate with the interdigitated sensing electrodes exposed;
wherein the polymer layer is electrographed onto the exposed interdigitated sensing electrodes.

US Pat. No. 10,336,604

BREAKAWAY HOSE SUPPORT

OPW FUELING COMPONENTS, L...

1. A fluid dispensing system comprising:a support structure;
a hose configured to dispense fluid therethrough;
a support cable directly or indirectly coupled to said hose, wherein said hose is directly or indirectly releasably coupled to said support structure via said cable and a breakaway assembly, said breakaway assembly including a first portion coupled to the cable, a second portion coupled to the hose by a pin oriented transverse to an axis of the hose and defining a pivot axis, and a third portion configured to releasably attach said first and second portions and to allow separation of said first and second portions by deformation of said third portion and not breakage thereof when a predetermined force is applied thereto by said cable; and
an extension and retraction mechanism configured to provide an adjustable effective length to said cable.

US Pat. No. 10,336,603

AEROSOL REFILL CARTRIDGE WITH RFID CHIP

1. A refill bottle for dispensing consumer products refilled at a refill station, comprising:an external refill bottle housing;
a reusable internal aerosol cartridge within the external refill bottle housing, the reusable aerosol cartridge including a compressed gas chamber and a product chamber;
a toggle valve coupled to the reusable internal aerosol cartridge and having an exterior end extending outside the refill bottle housing;
a nozzle connected to the exterior end of the toggle valve and including a first connector, a second connector, and a mixing chamber therebetween having at least one flow path;
a removable housing base; and
a read/write RFID tag disposed within the external refill bottle housing and associated with the reusable internal aerosol cartridge, the read/write RFID tag having a transmission frequency associated therewith, and the RFID tag recording information about a refill operation;
wherein the read/write RFID tag records data that enables the reusable internal cartridge to be identified and traced in the event of a recall.

US Pat. No. 10,336,602

FUEL DELIVERY MANAGEMENT SYSTEM

Franklin Fueling Systems,...

1. A fuel delivery management system, the system including:a console having:
a processor;
a touch-sensitive display;
a plurality of ports configured to facilitate communications with a plurality of lines, tanks, and pumps; and
a memory that contains instructions that, when executed by the processor, cause the processor to:
generate a home screen on the touch-sensitive display, the home screen having a navigation menu icon that, when activated by a user, causes the processor to generate a navigation window that overlays a portion of the home screen,
wherein the navigation window includes a plurality of user-interface elements including a first user-interface element that, when activated by a user,
causes the processor to enable user configuration of a second user-interface element,
wherein, when activated by a user subsequent to the user configuration, the second user-interface element causes the processor to present, on the touch-sensitive display, a screen that corresponds to the second user-interface element,
wherein, in addition to the first user-interface element, the plurality of user-interface elements in the navigation window further includes at least one user-interface navigation element that, when activated by a user, causes the processor to present, on the touch-sensitive display, a screen that corresponds to the activated user-interface navigation element, wherein:
the at least one user-interface navigation element includes a first user-interface navigation element and a second user-interface navigation element,
the first user-interface navigation element, when activated by a user, causes the processor to present, on the touch-sensitive display, a screen that corresponds to the first user-interface navigation element; and
the second user-interface navigation element, when activated by a user, causes the processor to present, on the touch-sensitive display, a screen that corresponds to the second user-interface navigation element, wherein the navigation menu icon is displayed:
 in a first location on the home screen,
 in the first location on the screen that corresponds to the first user-interface navigation element, and
 in the first location on the screen that corresponds to the second user-interface navigation element.

US Pat. No. 10,336,601

REMOTE FUELING STATION WITH FUEL PUMP ENCLOSURE

1. A remote fueling station in combination with a fuel storage tank supported above ground and having an outlet fitting, the remote fueling station comprising:a fuel pump having an inlet arranged to receive fuel from the fuel storage tank and an outlet arranged to dispense a pressurize flow of fuel therefrom;
a supply pipe assembly in connection from the outlet fitting of the fuel storage tank to the inlet of the fuel pump;
a dispenser nozzle in connection with the outlet of the fuel pump for dispensing the pressurize flow of fuel therefrom; and
an enclosure comprising a plurality of boundary panels supported about and surrounding the fuel pump so as to be arranged to restrict activation of the fuel pump by unauthorized persons;
the enclosure being supported on the fuel storage tank in fixed relation thereto so as to restrict removal of the enclosure from the fuel storage tank by unauthorized persons;
the supply pipe assembly comprising:
a rigid pipe in connection to the outlet fitting of the fuel storage tank;
a threaded pipe fitting in threaded connection to the rigid pipe at an intermediate location along the supply pipe assembly between the fuel pump and the outlet fitting of the fuel storage tank;
the threaded pipe fitting being mounted in fixed relationship on one of the boundary panels of the enclosure such that the supply pipe assembly extends through said one of the boundary panels; and
the fuel pump inlet being in connection with the threaded pipe fitting at an interior of the enclosure.

US Pat. No. 10,336,599

COVER FOR A WATER COOLER RESERVOIR BOTTLE

1. A cover for a water cooler reservoir bottle comprising:a body that defines an interior body surface, wherein the interior body surface of the body defines a cavity sized and shaped to receive a water cooler reservoir bottle and wherein the body does not completely cover an external surface of the water cooler reservoir bottle, wherein an exterior of the body is a three dimensional simulation of one of a human headgear, a human head and an animal head including visual representation of elements of one of a human headgear, a human head and an animal head, and wherein the body further comprises a body opening and the body opening exposes facial features defined on a water cooler reservoir bottle upon which the cover is placed, and wherein the exterior of the body simulates human headgear including visual representations of one of sports headgear, wig, motorcycle helmet, military helmet, fireman helmet, police helmet, postal headgear, fisherman headgear, sombrero, cowboy hat, coonskin cap, safari headgear, beach headgear, visor, construction hat, chef hat, Uncle Sam hat, Santa Clause hat, marching band hat, bridal veil, and knight headgear, wherein the exterior of the body is a three dimensional representation of sports headgear, and a cap member for a user's head and configured to be coupled to the body to allow the body to be worn by the user, and wherein a plurality of straps couple the cap to the body.

US Pat. No. 10,336,592

SHOPPING FACILITY ASSISTANCE SYSTEMS, DEVICES, AND METHODS TO FACILITATE RETURNING ITEMS TO THEIR RESPECTIVE DEPARTMENTS

Walmart Apollo, LLC, Ben...

1. An apparatus comprising:a plurality of motorized transport units configured to move through a retail shopping facility that is organized as a plurality of departments that present corresponding items for sale;
a central computer system having a network interface such that the central computer system wirelessly communicates with the plurality of motorized transport units and wherein the central computer system is configured to:
direct a particular one of the plurality of motorized transport units through the retail shopping facility to a particular mobile item container having at least one item disposed therein, the at least one item being designated for return to a particular one of the plurality of departments such that the at least one item can then be presented for sale;
cause the particular one of the plurality of motorized transport units to physically attach to the particular mobile item container; and
direct, via a wireless network connection, the particular one of the plurality of motorized transport units through the retail shopping facility with the attached particular mobile item container to the particular one of the plurality of departments by first confirming that at least one associate will be available in the particular one of the plurality of departments to remove corresponding items from the particular mobile item container for that department when the particular one of the plurality of motorized transport units arrives with the particular mobile item container.

US Pat. No. 10,336,591

PORTABLE WHEEL LIFTING SYSTEM

1. A portable wheel lifting system, comprising:an outer housing forming a cavity therein, the outer housing having:
at least two side walls inclined vertically towards a top of the outer housing;
an emergency light secured to the housing; and
an electrical switch secured to the housing;
a power supply connector configured to receive power from a vehicle and power the emergency light and the switch;
a lifting linkage system carried within the cavity of the outer housing and configured to extend in a direction upward outside the cavity, the linkage system having:
a first lower link;
a second lower link;
a first upper link;
a second upper link;
a first block pivotally attached to the first lower link and the first upper link; and
a second block pivotally attached to the second lower link and the second upper link;
a roller plate secured to the first upper link and the second upper link;
a first roller secured to the roller plate;
a second roller secured to the roller plate;
a threaded shaft engaged with the first block and the second block;
a motor rotatably attached to the threaded shaft, the motor is configured to rotate the threaded shaft, which in turn raises the roller plate outside the cavity of the outer housing; and
a plurality of wheels secured to the outer housing;
wherein the lifting linkage system receives power from the housing via activation of the electric switch to raise and lower the lifting linkage system; and
wherein rotation of the threaded shaft via the motor pushes the first block and the second block together, thereby causing the first lower link and the first upper link to pivot apart, as well as the second lower link and the second upper link to pivot apart, thereby raising the roller plate outside the cavity.

US Pat. No. 10,336,588

MOBILE CRANE

TADANO LTD., Kagawa (JP)...

1. A mobile crane comprising:a base vehicle;
a slewing base slewably supported by the base vehicle;
a boom derrickably supported by the slewing base;
a derrick cylinder raising and lowering the boom;
a jib support removably attached to a tip of the boom;
a luffing jib derrickably supported by the jib support;
a first mast rotatably supported by the jib support or the luffing jib;
a second mast rotatably supported by the jib support;
a first tension link connecting the luffing jib and the first mast to each other;
a second tension link connecting the first mast and the second mast to each other;
a winch hoisting down a rope connected to the second mast to rotate the second mast to a side of the luffing jib and hoisting up the rope to rotate the second mast to a side opposite to the luffing jib;
an operating unit outputting a signal according to a user operation of derrick of the boom; and
a control unit controlling an operation of the derrick cylinder and the winch, wherein
the control unit causes the derrick cylinder to raise the boom in response to a signal output from the operating unit and stops the derrick cylinder in response to a derrick angle of the boom reaching a maximum angle corresponding to a hoisted-down length of the rope.

US Pat. No. 10,336,586

APPARATUS, METHODS, COMPUTER PROGRAM, AND COLLECTION FOR GENERATING IMAGE DATA OF LOAD STACK

1. An apparatus comprising:a camera configured to generate image data of a load stack in an operating area of a load handling apparatus, the load stack being formed with a plurality of loads stacked together including a first load and a second load stacked on top of the first load; and
a processor configured to add a sight apparatus to the image data to generate a composed image for improving precision of a load handling operation by the load handling apparatus,
wherein the sight apparatus has several lines, the several lines comprising at least two parallel line pairs, the at least two parallel line pairs including a first line pair and a second line pair, lines of the first line pair corresponding to at least two opposite sides of the first load and set at a distance from each other that corresponds to a distance between the two opposite sides of the first load, and lines of the second line pair corresponding to at least two opposite sides of the second load and set at a distance from each other that corresponds to a distance between the two opposite sides of the second load, and
wherein the first line pair and the second line pair represent different heights of the first load and the second load respectively.

US Pat. No. 10,336,585

EGG LIFTING DEVICE, AND ASSOCIATED SYSTEMS AND METHODS

Zoetis Services LLC, Par...

1. An egg sampling station, comprising:a plurality of processing devices, each having a needle configured to extract a sample from a respective avian egg aligned therewith;
a plurality of egg lifting devices configured to carry avian eggs to the processing devices and align co-linearly therewith along a longitudinal axis thereof, each egg lifting device configured to allow access to a respective avian egg by a respective processing device, each processing device being configured to extend within a respective egg lifting device when co-linearly aligned therewith, and each egg lifting device having a securing arrangement configured to engage and deflect about an egg carried by an egg container such that the egg is seated within the securing arrangement for removal thereof from the egg container, the securing arrangement being formed of a flexible material and being resiliently deflectable to secure an egg and position the egg in a predetermined orientation;
an egg support assembly comprising a plurality of pedestals configured to support the eggs while secured by the egg lifting devices and during interaction with the processing devices; and
a track system to which the egg lifting devices are operably engaged, the track system being configured to transport the egg lifting devices for alignment with the respective processing devices and pedestals.

US Pat. No. 10,336,584

LIFTING AND TRANSPORTING SYSTEM

12. A coupling element for attachment to an object to be lifted and transported by jack units, each of the jack units having,a skate,
a tongue extending along a tongue axis and vertically movable relative to the skate, the tongue having tongue bearing surfaces that extend parallel to the tongue axis, and
a selectively releasable tongue latching structure, andthe coupling element comprising:a first coupling slot extending along a first slot axis and configured to slidably accept the tongue of one of the jack units, said first coupling slot having first slot bearing surfaces configured to slidably and supportably engage the tongue bearing surfaces so as to limit motion therebetween to translation along the first slot axis, said first coupling slot having a depth extending along the first slot axis that is greater than both a height extending orthogonally with respect to the first slot axis and a width extending orthogonally with respect to the first slot axis;
a first slot latching structure configured to be releasably engaged by the tongue latching structure when the tongue bearing surfaces are engaged with said first slot bearing surfaces, such engagement of the tongue latching structure with said first slot latching structure acting to block slidable motion between the tongue bearing surfaces and said first slot bearing surfaces;
a second coupling slot extending along a second slot axis that is orthogonal to the first slot axis and configured to slidably accept the tongue, said second coupling slot having second slot bearing surfaces configured to slidably and supportably engage the tongue bearing surfaces so as to limit motion therebetween to translation along the second slot axis, said second coupling slot having a depth extending along the second slot axis that is greater than both a height extending orthogonally with respect to the second slot axis and a width extending orthogonally with respect to the second slot axis; and
a second slot latching structure configured to be releasably engaged by the tongue latching structure when the tongue bearing surfaces are engaged with said second slot bearing surfaces, such engagement of the tongue latching structure with said second slot latching structure acting to block slidable motion between the tongue bearing surfaces and said second slot bearing surfaces.

US Pat. No. 10,336,583

LIFTER AND METHOD FOR MOVING TRAFFIC BARRIERS

Vacuworx Global, LLC, Tu...

1. A method for lifting a traffic barrier, the method comprising:operating a rotator of a barrier lifter connected to a boom, the barrier lifter including
at least one pinned connector configured for connecting the barrier lifter to the boom;
the rotator located below and connected to the at least one pinned connector, the rotator capable of rotating said lifter relative to the boom;
a pair of opposing axes located below the rotator and running parallel to one another;
a pair of opposing arms, each arm connected at an upper end to a respective axis of the pair of opposing axes, the arms rotatable relative to one another between an open position and a closed position; and
a cross-member pivotally connected to a respective lower end of each arm of the pair of opposing arms, the cross-member including a gripping surface;
operating the pair of opposing arms into the open position;
operating the rotator to align the arms with a traffic barrier;
lowering the boom and lifter onto the traffic barrier;
operating the pair of opposing arms into the closed position wherein the gripping surface of each arm is in contact with and applying pressure to a respective opposing surface of the traffic barrier;
lifting the boom, lifter and traffic barrier;
placing the traffic barrier over a desired location;
lowering the boom, lifter and traffic barrier wherein the traffic barrier is placed on the desired location; and
operating the pair of arms to return into the open position.

US Pat. No. 10,336,582

PASSENGER TRANSPORT SYSTEM WITH MONITORING AND MARKING DEVICE FOR CHARACTERIZING DEFECTIVE STEP UNITS

Inventio AG, Hergiswil (...

1. A passenger transport system, comprising:multiple step units configured to be moved one behind the other continuously along a predefined movement path during normal operation;
a comb plate arranged at a fixed position relative to the predefined movement path; and
a monitoring device configured to monitor an actual position of a currently monitored step unit relative to the predefined movement path and to detect a deviation of the actual position from the predefined movement path by more than an allowable tolerance value and activate a marking device in response thereto;
wherein the marking device;
upon being activated, is configured to provide the currently monitored step unit and/or a step unit spatially correlating to the currently monitored step unit in a defined manner with a marking.

US Pat. No. 10,336,581

SYSTEM AND METHOD FOR REDUCING BELT NOISE

OTIS ELEVATOR COMPANY, F...

1. An elevator system, comprising:an elevator car;
a counterweight;
at least one belt connecting the car and counterweight; and
at least one sheave having at least one surface for engagement with the at least one belt;
wherein said at least one belt is flat and at least part of the at least one surface has a plurality of features thereon configured to interact with the belt for reducing unwanted noise from interaction between the surface and the at least one belt;
wherein the plurality of features comprises at least one of indentations or projections.

US Pat. No. 10,336,580

METHOD AND DEVICE FOR CHECKING THE INTEGRITY OF LOAD BEARING MEMBERS OF AN ELEVATOR SYSTEM

Kone Corporation, Helsin...

1. A method of testing at least one load bearing member of an elevator system, the at least one load bearing member including tensile elements of electrically conductive material encapsulated in a case, the method comprising:transmitting a first source pulse through a first one of the tensile elements and a second source pulse through a second one of the tensile elements, and
determining a condition of the tensile elements based on a first feedback signal received via the first one of the tensile elements and a second feedback signal received via the second one of the tensile elements.

US Pat. No. 10,336,579

METAL COATING OF LOAD BEARING MEMBER FOR ELEVATOR SYSTEM

OTIS ELEVATOR COMPANY, F...

1. A method for forming a belt for an elevator system comprising:forming one or more tension elements;
at least partially enclosing the one or more tension elements in a jacket material, the jacket material defining:
a traction surface;
a back surface opposite the traction surface together with the traction surface defining a belt thickness; and
two end surfaces extending between the traction surface and the back surface defining the belt width; and
applying a metallic coating layer via application of solid metal particles to at least one end surface of the two end surfaces after at least partially enclosing the one or more tension elements in the jacket material to improve fire retardation properties of the belt;
wherein applying the metallic coating layer further comprises:
urging a carrier gas flow through a nozzle;
injecting a metallic powder material into the carrier gas flow;
impacting the metallic powder on the at least one end surface; and
adhering the metallic powder to the at least one end surface.

US Pat. No. 10,336,578

ELEVATOR SYSTEMS

1. A wind turbine comprising:a wind turbine tower;
a plurality of working platforms fixed at different heights along the wind turbine tower and configured to allow workers to perform maintenance; and
an elevator system arranged within the wind turbine tower, the elevator system comprising:
an elevator cabin;
an upper transverse element provided above the elevator cabin and adapted to be guided along a traction wire rope and/or a safety wire rope; and
a support structure, which is adapted to support the upper transverse element and substantially impede its movement in a downwards direction and in a horizontal direction, and to allow movement of the upper transverse element in an upwards direction, wherein
the support structure is arranged with one of the working platforms; wherein one or more of the working platforms comprise a platform fence, and wherein the support structure is arranged with or formed by the platform fence.

US Pat. No. 10,336,577

BRAKING SYSTEM FOR AN ELEVATOR SYSTEM

OTIS ELEVATOR COMPANY, F...

1. An elevator system comprising:a hoistway; and
an elevator car disposed in the hoistway, the elevator car comprising:
a first braking device configured to engage a first braking surface in a first direction in the event of a guidance occurrence; and
a second braking device configured to engage a second braking surface in a second direction in the event of the guidance occurrence;
wherein in the event of the guidance occurrence, the first braking surface and the second braking surface configured to limit rotation of the elevator car.

US Pat. No. 10,336,575

GROUP CALL MANAGEMENT

KONE CORPORATION, Helsin...

1. A method for controlling groups calls in an elevator system, the method comprising the steps of:receiving a first identification of a user from an elevator calling panel, then;
receiving a call from the elevator calling panel from the user, the call indicating that a group of people will be entering an elevator and a number of passengers will be in the group, then;
after the user and the group enters a called elevator car, requesting a second identification of the user via the elevator system, and performing a second identification of the user via an RFID-based keycard or near field communication implemented on a mobile phone of the user;
determining the number of passengers in the group entering into the elevator using a weighing device or machine vision;
if the determined number of passengers matches the indicated number of passengers, then starting an elevator ride of the called elevator car; and
if the determined number of passengers does not match the indicated number of passengers, preventing the starting of the elevator ride of the called elevator car.

US Pat. No. 10,336,574

ELEVATOR OPERATION PANEL

MITSUBISHI ELECTRIC CORPO...

1. An elevator operation panel, comprising a casing having a rear part and a front part that is joined to the rear part,wherein the front part includes a frame body and a front surface plate disposed on an opposite side of the frame body to the rear part,
the frame body includes a first vertical frame disposed on one width direction side and a second vertical frame disposed on another width direction side,
a fixing member is laid across the first vertical frame and the second vertical frame,
a holding member for holding the front surface plate on the frame body is fixed to the fixing member, and
the holding member includes a holding portion that overlaps a vertical direction end portion of a front surface of the front surface plate, and a fastening portion that projects rearward from the holding portion and is screwed to the fixing member.

US Pat. No. 10,336,573

PRE-ALLOCATION OF AN ELEVATOR CALL

KONE CORPORATION, Helsin...

1. A method of pre-allocating an elevator call, comprising:receiving, at an elevator group controller of an elevator system with destination control, a first signal indicating that a passenger is detected to be approaching the elevator system at one of multiple floors associated with the elevator system, the first signal being sent in response to a distance sensor of the elevator system at said one of said multiple floors detecting said passenger within a predetermined distance from a destination control panel of the elevator system at said one of said multiple floors; and
in response, initiating allocation of an elevator call for the detected passenger, with said one of said multiple floors assigned as the departure floor for said elevator call prior to receiving a second signal indicating a destination floor selected by the detected passenger; and
receiving, at the elevator group controller, a second signal indicating a destination floor selected by the detected passenger.

US Pat. No. 10,336,571

MULTIPLE HIGH PRESSURE FLEXIBLE LANCE HOSE TAKE UP DRUM

STONEAGE, INC., Durango,...

1. A take-up drum apparatus for a plurality of flexible high pressure fluid cleaning lance hoses comprising:a base;
a hollow take-up drum assembly rotatably supported from the base via a rotary swivel, wherein the drum assembly includes a hollow cylindrical shell having a bottom plate, a cylindrical side wall, a high pressure fluid supply connection and a manifold positioned on the bottom plate of the shell for connection of one end of each of a plurality of flexible lance hoses to the high pressure fluid supply connection;
a support arm extending from the base outside of and across the side wall of the shell; and
one or more guide tubes supported by the support arm for guiding flexible lance hoses into and out of the take-up drum assembly.

US Pat. No. 10,336,570

CORD ORGANIZER

1. A cable organizer comprising:a housing further comprising a housing inner circular track, an opening, and an attachment hole therein, and a side wall for the housing that is an exterior surface of the cable organizer that is opposite an exterior side wall of a rotational component once assembled, a circumferential edge wall that is a narrow edge that extends orthogonally from the side wall for the housing additionally comprising a lip that is a narrow flange that extends inward orthogonally from the circumferential edge wall, and a curved arcuate slice in the housing that removes a portion of the side wall, circumferential edge, and lip to create an edge opening;
the rotational component further comprising at least one hole on a surface of the rotational component, further comprising a rotational inner circular track wherein the rotational inner circular track operably connects with the housing inner circular track, thereby providing friction, and an insertion hole receiver; and
a plug, wherein the plug is inserted through the attachment hole on the housing and continues to the insertion hole receiver whereby the plug operably holds the cable organizer together.

US Pat. No. 10,336,569

APPARATUS FOR ORGANIZING CORD ATTACHED DEVICES

1. A packing device for organizing objects with attached cords, said packing device comprising:i. a packing tube; and
ii. a pulling assembly having a string, a puller attached to said string at a first end of said string, and a first fastener attached to a second end of said string, wherein:
(1) said string and said first fastener are adapted to be pulled inside said tube when said puller is pulled;
(2) said first fastener is adapted to be attached to said cords; and
(3) said tube incorporates an elongated track wherein said puller moves along said track when said cords are pulled into said tube, and wherein said elongated track does not extend to either end of said tube.

US Pat. No. 10,336,566

FEED TAPE DISPENSER

Shurtech Brands, LLC, Av...

15. A tape dispenser comprising a frame having a top wall and opposed side walls, said top wall connecting the opposed side walls; a tape mount disposed on an interior surface of each of the side walls and being adapted to secure a roll of tape therebetween; a cutter blade disposed on a forward region of the frame and adapted to cut tape from the roll; a bar disposed on the interior surface of one side wall, said bar comprising a hollow semi-cylinder extending between greater than 40% and less than 90% of a distance between said opposed side walls to provide a space between an end of the bar and one side wall.

US Pat. No. 10,336,565

DRIVERS

Hewlett-Packard Developme...

1. A driver comprising:an elongate shaft having a polygon shaped cross-section including at least two parallel sides;
at least one drive assembly comprising:
a housing, the housing having an orifice for receiving the elongate shaft;
a drive wheel located at least partially within the housing, the drive wheel having a bore with a cross-section shaped so that the internal surface of the bore contacts the circumference of the elongate shaft, the bore having at least two fulcrum surfaces so that the drive wheel is pivotable about the elongate shaft; wherein
the housing is slideable relative to the elongate shaft.

US Pat. No. 10,336,564

MEDIUM TRANSPORTING APPARATUS AND RECORDING APPARATUS

Seiko Epson Corporation, ...

1. A medium transporting apparatus, comprising:an endless conveyor belt having an outer surface to which a medium adheres;
at least two rollers, which are a first roller and a second roller, around which the conveyor belt extends, the second roller being located downstream of the first roller in a medium transporting direction; and
a support member that supports an inner surface of the conveyor belt at a position between the first roller and the second roller, wherein
the support member includes a hollow-containing portion that is formed at an upstream end of the support member in the medium transporting direction, the hollow-containing portion having a plurality of hollows formed therein in a width direction that intersects the medium transporting direction, the plurality of hollows being formed in a support surface that supports the conveyor belt,
wherein each of the hollows is formed so as to taper from an upstream end to a downstream end in the medium transporting direction.

US Pat. No. 10,336,563

SHEET FEEDING APPARATUS INCLUDING SHEET STORAGE UNIT WHICH CAN BE PUSHED INTO OR PULLED OUT OF APPARATUS BODY, AND IMAGE FORMING APPARATUS

KYOCERA Document Solution...

1. A sheet feeding apparatus comprising:an apparatus body;
a sheet storage unit which is opened to an upper side and has a storage space for storing a stack of sheets, the sheet storage unit being able to be pushed into and pulled out of the apparatus body;
a lift plate which is disposed parallel to a bottom wall of the storage space and can be raised and lowered;
a lift unit which raises and lowers the lift plate;
a first cursor provided upright on the bottom wall at a back side with reference to a push-in direction in which the sheet storage unit is pushed into the apparatus body such that the first cursor extends along a sheet feeding direction, the first cursor restricting an end, in the back side, of the stack of sheets; and
an urging member disposed between rear wall and the first cursor to urge the first cursor, the rear wall defining an end in the back side of the storage space, the urging member being elastically deformable in a push-in/pull-out directions,
wherein the first cursor comes in contact with a first side face, which is a side face of the stack of sheets, and is movable between a restriction position where the first cursor restricts the stack of sheets from moving in the push-in direction and a retracted position to which the first cursor retracts in the back side from the restriction position,
the lift plate includes a fixed plate connected to the lift unit and a movable plate on which the stack of sheets is placed, the movable plate being movable on the fixed plate in the push-in/pull-out direction, and
by inertia force of the stack of sheets, which generates when the sheet storage unit is pushed into the apparatus body and stops at a predetermined position, the stack of sheets moves together with the movable plate to the back side of the storage space to push the first cursor, the first cursor moves, by the inertia against an urging force of the urging member, toward the retracted position and then moves, pushing back the stack of sheets, by resilience of the urging member to the restriction position.

US Pat. No. 10,336,560

TRANSFER APPARATUS

Azbil Corporation, Tokyo...

1. A transfer apparatus comprising:a first rod-shaped member comprising a magnetic material;
a first terminal member configured to allow insertion of a first end portion of the first rod-shaped member;
a second terminal member configured to allow insertion of a second end portion of the first rod-shaped member;
a second rod-shaped member comprising a magnetic material;
a third terminal member configured to allow insertion of a first end portion of the second rod-shaped member;
a fourth terminal member configured to allow insertion of a second end portion of the second rod-shaped member;
a coupling member configured to couple the second terminal member and the third terminal member; and
an opposite member facing a part of side surfaces of the first and second rod-shaped members and comprising a magnetic material,
wherein the first rod-shaped member and the first terminal member are not fixed, the first rod-shaped member and the second terminal member are fixed to each other, and when the first and second rod-shaped members rotate, the opposite member moves along central axes of the first and second rod-shaped members.

US Pat. No. 10,336,558

TRANSFER APPARATUS, TRANSFER SYSTEM, AND TRANSFER METHOD

HIRATA CORPORATION, Shin...

1. A transfer apparatus for loading/unloading a work into/from a processing apparatus, comprising:a running main body configured to move in a horizontal direction;
a robot main body mounted on the running main body;
at least one transfer arm provided with the robot main body, the transfer arm including an arm portion pivotally provided with respect to the robot main body and a hand portion which is pivotally provided with respect to the arm portion and is configured to grip the work; and
a control unit configured to horizontally swing the arm portion and move the main body in order for the hand portion to linearly move the work, when the hand portion facing the processing apparatus loads/unloads the work into/from the processing apparatus,
wherein the running main body includes a lifting mechanism configured to move the robot main body up and down,
wherein the transfer apparatus further compromises a cover member placed below the robot main body and above an oil pan disposed on the processing apparatus,
wherein the lifting mechanism is configured to move the cover member up and down with the robot main body,
wherein the cover member has a surface inclining toward the oil pan,
wherein the hand portion has:
a hand main body connected to the arm portion; and
two chuck portions provided to the hand main body,
wherein each chuck portion has:
a gripping mechanism configured to grip the work; and
a pivoting mechanism configured to pivot the gripping mechanism about a horizontal axis perpendicular to an open-close direction of the gripping mechanism, and
wherein control unit controls the up and down movement of the lifting mechanism, a pivoting of the hand portion, the gripping mechanism and the pivoting mechanism.

US Pat. No. 10,336,557

TRANSPORT SECTION, METHOD FOR ADJUSTING AND/OR READJUSTING AT LEAST ONE TRANSPORT TRACK WITHIN A TRANSPORT SECTION, AND PACKAGING FACILITY

Krones Aktiengesellschaft...

1. A transport section (17) for feeding article arrangements (5) in a transport direction (TR) to a packaging module (18) for the article arrangements (5), the transport section (17) comprising:a transfer plate (15), on which the articles (2) of the article arrangements (5) are movable in transport direction (TR) in a sliding manner, wherein at least one area of the transfer plate (15) has openings that are formed to be orthogonal to the transport direction (TR) of the articles (2);
one or more pushing devices (16) disposed above the transfer plate (15), for moving the articles (2) on the transfer plate (15), wherein the one or more pushing devices (16) are movable in transport direction (TR);
one or more outer guide elements (20) disposed on the transfer plate (15), with the one or more outer guide elements (20) laterally delimiting the transport section (17); and
one or more inner guide elements (21) disposed on the transfer plate (15), wherein the inner guide elements (21) are readjustable by at least one readjustment mechanism that is disposed at least partly below the transfer plate (15), and wherein at least a portion of the readjustment mechanism is movable within the openings of the transfer plate (15).

US Pat. No. 10,336,556

CONVEYING DEVICE TO BRING TOGETHER INDIVIDUAL PACKAGES FROM SEVERAL TRANSFER CONVEYORS

1. The conveying device to bring together individual packages from at least one transfer conveyor onto a discharge conveyor, comprising an aligning conveyor having a receiving end, which a feeding end or feeding ends arranged next to each other of the transfer conveyor or transfer conveyors join, and a feeding end arranged parallel to the receiving end, which the receiving end of the discharge conveyor joins, wherein a guide element having a guide surface, arranged vertically to and directly over a conveying surface of the aligning conveyor, is located between a first external side edge of the transfer conveyor or a first transfer conveyor and an opposite first side edge of the discharge conveyor, a conveying direction of the aligning conveyor having a longitudinal component, which is directed from the transfer conveyor or first transfer conveyor to the discharge conveyor and with the conveying direction forms an angle (?), and having a transverse component directed perpendicularly against the guide element; andwherein the aligning conveyor has a parallelogram-shaped conveying surface, wherein the angle (?) amounts to less than 90° and the feeding end is parallel and transversely offset to the receiving end.

US Pat. No. 10,336,555

BAGGAGE HANDLING AND DELIVERY SYSTEM

King Saud University, Ri...

1. A baggage handling and delivery system, comprising:a first laterally extending conveyer belt having opposed first and second ends, the first laterally extending conveyer belt being adapted to transport at least one baggage item along a first lateral direction;
a second laterally extending conveyer belt having opposed first and second ends, the second laterally extending conveyer belt being adapted to transport the at least one baggage item along a second lateral direction, the second lateral direction being opposite the first lateral direction;
a first longitudinally extending conveyer belt having opposed first and second ends, the first end thereof being positioned adjacent the second end of the first laterally extending conveyer belt, the second end of the first longitudinally extending conveyer belt being positioned adjacent the first end of the second laterally extending conveyer belt, the first longitudinally extending conveyer belt being adapted to transport the at least one baggage item along a first longitudinal direction;
a second longitudinally extending conveyer belt having opposed first and second ends, the first end thereof being positioned adjacent the second end of the second laterally extending conveyer belt, the second end of the second longitudinally extending conveyer belt being positioned adjacent a central portion of the first laterally extending conveyer belt, the second longitudinally extending conveyer belt being adapted to transport the at least one baggage item along a second longitudinally direction, the second longitudinal direction being opposite the first longitudinal direction;
a third laterally extending conveyer belt having opposed first and second ends, the third laterally extending conveyer belt being adapted to transport the at least one baggage item along the second lateral direction, the first end of the third laterally extending conveyer belt being positioned adjacent a central portion of the first longitudinally extending conveyer belt;
a third longitudinally extending conveyer belt having opposed first and second ends, the third longitudinally extending conveyer belt being adapted to transport the at least one baggage item along the first longitudinal direction, the first end of the third longitudinally extending conveyer belt being positioned adjacent the second end of the third laterally extending conveyer belt, the second end of the third longitudinally extending conveyer belt being positioned adjacent a central portion of the second laterally extending conveyer belt;
a scanner positioned adjacent the first end of the first laterally extending conveyer belt for reading identifying information associated with the at least one baggage item;
a first pushing device mounted adjacent an intersection between the first longitudinally extending conveyer belt and the first end of the third laterally extending conveyer belt, the first pushing device being adapted to selectively push the at least one baggage item to divert the at least one baggage item from traveling on the first longitudinally extending conveyer belt to travel on the third laterally extending conveyer belt;
a first pickup station positioned adjacent an intersection between the second end of the first longitudinally extending conveyer belt and the second laterally extending conveyer belt for selectively receiving the at least one baggage item; and
a second pickup station positioned adjacent an intersection between the second end of the third longitudinally extending conveyer belt and the second laterally extending conveyer belt for selectively receiving the at least one baggage item.

US Pat. No. 10,336,554

DEVICE FOR SEPARATING AND ALIGNING PIN-SHAPED PIECE GOODS

1. A device for separating and aligning pin-shaped piece goods exhibiting a head and a shank, the device comprising:a generally funnel-shaped receptacle for receiving the piece goods, the generally funnel-shaped receptacle having:
a central transverse place,
two wall sections which delimit the receptacle in a front area, and
a rear wall,
wherein the wall sections and the rear wall are arranged opposite one another and are inclined outwards at an angle to the central transversal plane of the receptacle;
an endlessly circulating conveying means which is arranged underneath a recess, wherein the recess spaces apart the two wall sections and is arranged at the same angle as the wall sections inclined relative to the central transversal plane, the endlessly circulating conveying means conveying the piece goods from a receiving plane to a higher discharge plane;
wherein the endlessly circulating conveying means has a conveying plane provided with drivers;
wherein the recess is delimited by parallel front edges of the wall sections which are arranged in a V-shape tapering towards the conveying means and terminate in at least one of: above the conveying means and in a plane with the conveying means;
wherein the drivers are in the form of cylindrical pins which are arranged at a distance from one another in the direction of circulation of the conveying means and extend generally perpendicular to the conveying plane of the conveying means.

US Pat. No. 10,336,553

METHOD AND HANDLING DEVICE

Krones Aktiengesellschaft...

1. A method for reducing bundles (2) being conveyed at a transport speed in a transport direction (TR) in n rows (3) to a smaller number of continuing transport rows wherein comprising:forming a space (8) in each instance at least between the individual bundles (2) of at least one incoming and continuing transport row (3-1, 3-3), wherein the length of the space (8) corresponds to at least the value of a longitudinal extent of an individual bundle (2) in transport direction (TR), and
simultaneously transferring at least two bundles (2) of at least one row (3-2) to be broken up by a gripper (10) into a number of consecutive spaces (8) between bundles (2) of at least one continuing transport row (3-1, 3-3) adjacent to the at least one row (3-2) to be broken up, wherein the number of consecutive spaces (8) corresponds to the number of the bundles (2) being transferred.

US Pat. No. 10,336,550

SUPPORT STRUCTURE AND METHOD FOR SUPPORTING AN ENCLOSED BELT CONVEYOR

SANDVIK INTELLECTUAL PROP...

1. A support structure for supporting an enclosed belt conveyor between two transport units, the support structure comprisinga first end element having a main extension in a longitudinal direction, a width extension in a width direction orthogonal to the longitudinal direction, and a height extension in a height direction orthogonal to the longitudinal and the width direction;
at least one guide assembly arranged to engage opposite longitudinal edges of a belt of an enclosed belt conveyor; and
a first telescopic element connected to the first end element, wherein an outer end of the first end element has a first end connector arranged to form a connection with a first transport unit, the connection allowing for rotation about an axis parallel to the width direction and about an axis parallel to the longitudinal direction, the first end element having an inner connector arranged to form a connection allowing for rotation about an axis parallel to the height direction, and the first telescopic element being arranged to form a connection with a second end element, a link element, or a transport unit connected to the inner connector of the first end element.

US Pat. No. 10,336,549

QUICK DISCONNECT ASSEMBLIES

1. A quick release apparatus, comprising:a first roller segment and a second roller segment configured to be joined along an opposing mating surface to form a body configured to rotate about an axis;
a plurality of aligned apertures extending through the opposed mating surface of each of the first roller segment and the second roller segment, the plurality of aligned apertures comprising a first aligned aperture of the aligned apertures defined in the second roller segment; and
a threaded insert that is configured to be received in the first aligned aperture, wherein the threaded insert is threaded to receive a fastener through an aperture of the first roller segment, thereby securing the first and second roller segments together and fixing the insert within the second roller segment.

US Pat. No. 10,336,548

METHOD FOR FILLING THE POCKETS OF A TRANSPORT DEVICE IN THE FORM OF A SUSPENSION CONVEYOR AND DEVICE FOR CARRYING OUT SAID METHOD

FERAG AG, Hinwil (CH)

1. A transport device in the form of a suspension conveyor with a filling device for filling pockets, the transport device comprising:a first device for opening the pockets;
a second device for filling the opened pockets; and
a third device for closing the filled pocket, wherein the first device, the second device, and the third device are arranged one behind the other and separated from one another in a transport direction for the pockets, wherein advancing the pockets is carried out via a first running rail, and that moving away the filled and closed pockets is carried out via a second running rail which is arranged offset with respect to the first running rail.

US Pat. No. 10,336,547

SAMPLE CONTAINER HANDLING DEVICE

Roche Diagnostics Operati...

1. A sample container handling device, the sample container device comprising:a linear transport unit adapted to transport sample containers in horizontal orientation to a release position; and
a release unit comprising a release blade segment adapted to abut a respective sample container in the release position along a side line and to push the sample container away from the transport unit, wherein the release unit is configured to rotate the release blade segment around an axis such that a plurality of sample containers are sequentially pushed away from the linear transport unit while the release blade segment is rotating in a constant rotational direction and wherein the linear transport unit is configured to sequentially transport sample containers to the release position synchronized with the rotation of the release blade segment, wherein the release unit comprises a first sensor for sensing a rotational position of the release blade segment.

US Pat. No. 10,336,546

WINDROW CHUTE WITH INDEPENDENTLY MOVABLE CHUTE SECTIONS

CNH Industrial America LL...

1. A windrow chute assembly for an agricultural vehicle, the windrow chute assembly comprising:a chute body comprising a plurality of movable chute sections, the plurality of movable chute sections comprising a first chute section and a second chute section,
the first chute section having a first proximal end for receiving material from the agricultural vehicle, a first distal end opposite the first proximal end for discharging material from the agricultural vehicle, and a first chute axis extending between the first proximal end and the first distal end,
the second chute section having a second proximal end for receiving material from the agricultural vehicle, a second distal end opposite the second proximal end for discharging material from the agricultural vehicle, and a second chute axis extending between the second proximal end and the second distal end,
the first proximal end of the first chute section and the second proximal end of the second chute section defining a transverse axis therebetween, the first chute section being displaceable so as to define a first angle of displacement between the first chute axis and the transverse axis, and the second chute section being displaceable so as to define a second angle of displacement between the second chute axis and the transverse axis, and
the first chute section and the second chute section being displaceable toward one another to a closed configuration, in which a sum of the first angle of displacement and the second angle of displacement is a maximum, and displaceable away from one another to an open configuration, in which the sum of the first angle of displacement and the second angle of displacement is a minimum;
wherein the first chute section is pivotally mountable on a first pivot axis, and the second chute section is pivotally mountable on a second pivot axis offset from the first pivot axis.

US Pat. No. 10,336,545

TRANSPORT CHUTE HAVING DRIVE MEANS

Siemens Aktiengesellschaf...

1. A transport chute suitable for use as a storage facility for goods which can be disposed one above another, the transport chute comprising:a slide section having an inclined sliding surface with a direction of fall along said inclined sliding surface, said inclined slide section being interrupted by at least one interruption such that said inclined sliding surface is divided into at least one upper sliding surface and one lower sliding surface, said interruption configured to facilitate a formation of at least two layers, disposed one above the other, of the goods beneath said interruption;
at least said lower sliding surface having at least one drivable and controllable driver for transporting the goods contrary to the direction of fall on which the goods of a bottom layer can rest at least partially for their transportation; and
said at least one upper sliding surface and said lower sliding surface both having a direction of inclination coinciding with the direction of fall.

US Pat. No. 10,336,543

SELECTIVE ENCODING OF PACKAGES

Wing Aviation LLC, Mount...

1. A computer-implemented method comprising:receiving a work request indicative of at least one of: a first item or one or more work request parameters, wherein the first item is one of a plurality of items stored in an item-storage environment, and wherein each item is associated with a co-located identifier device; and
in response to receipt of the work request:
identifying, by a processor, the first item;
determining, by the processor, a target location corresponding to the first item;
selecting, by the processor, a first unmanned aerial vehicle (UAV) from a plurality of encoder UAVs available for deployment in the item-storage environment, wherein each encoder UAV comprises an encoder device configured to encode data to the identifier devices associated with the plurality of items; and
causing the first UAV to: (a) travel to the target location, and (b) while hovering at or near to the target location, encode particular identification data to the identifier device associated with the first item, wherein the particular identification data comprises at least the work request parameters.

US Pat. No. 10,336,542

SYSTEMS AND METHODS FOR MAXIMIZING TOTE CONTENTS

Amazon Technologies, Inc....

6. A system, comprising:a first conveyor configured to move a plurality of items disposed thereon;
a shuttle having one or more motorized wheels configured to move the shuttle between the first conveyor and a tote, the shuttle comprising a second conveyor being configured to receive and support at least one item of the plurality of items as the at least one item is transferred from the first conveyor to the tote; and
a carrier configured to support the tote so that a top surface of a tote base of the tote is disposed at an angle offset from a horizontal plane by between 5 degrees and 10 degrees.

US Pat. No. 10,336,539

AUTOMATED CRYOGENIC STORAGE SYSTEM

Brooks Automation, Inc., ...

1. A cryogenic storage system comprising:a freezer configured to store a plurality of sample racks in a cryogenic environment, the freezer including a door enabling access to the cryogenic environment through a port at the top portion of the freezer;
a rack carrier configured to suspend each of the plurality of sample racks by a respective rack top portion, the rack carrier including a rack mount having a plurality of openings, the rack mount suspending each of the plurality of sample racks at a respective one of the plurality of openings; and
a retrieval system including:
a drive system mounted to the top portion of the freezer, the drive system being configured to rotate the sample racks to align a selected one of the sample racks with the port;
an insulating sleeve configured to house the selected one of the sample racks above the port, the insulating sleeve including a sleeve port for enabling a user to access a selected sample box from the selected one of the sample racks; and
a rack puller, the rack puller being configured to engage the selected one of the sample racks and elevate the selected one of the sample racks through the port and into the insulating sleeve.

US Pat. No. 10,336,538

PORTABLE HYDRAULIC SIDE-LOADER SYSTEM

1. A side-loader for loading debris into an open container having a base and a plurality of walls extending upwardly from the base, one of said walls being a side wall, an upper lip along said wall and a bottom surface along the base of said wall thereof comprises:a pair of spaced vertical arms having hooks at the upper ends thereof to engage the upper lip of the container side wall and retractable feet at the lower ends of the arms having a shelf to engage the bottom surface of the container base and having caster wheels at the end thereof;
a pivotal bucket to receive debris having a base and upwardly extending walls and having a pair of caster wheels mounted on the outer wall thereof to permit movement along the ground;
a pair of spaced arms mounted to the side walls of the bucket; and
means to activate the arms to move the bucket upwardly and pivot the bucket over the container to drop debris from the bucket in the container.

US Pat. No. 10,336,537

LEAF LIFTER AND METHOD OF USE

5. A device for lifting and carrying leaves, the device comprising:a flexible rectangular sheet having left, right, top, and bottom edges;
a right elongated rod, the elongated rod comprising PVC tubing and extending at least a substantial portion of a length of and being couple to the right edge;
a left elongated rod assembly, the left elongated rod assembly comprising a first piece of PVC tubing, a second piece of PVC tubing and a T-connector with respective ends of the first and second pieces being received in the T-connector, the left elongated rod assembly extending at least a substantial portion of a length of and being couple to the left edge;
an elongated handle comprising PVC tubing, a distal end of the elongated handle being coupled to the T-connector, and the elongated handle extending generally orthogonally outwardly from the left elongated rod assembly; and
first and second ground stakes, the first stake being coupled to a first end of the right elongated rod and the second stake being coupled to a second end of the right elongated rod;
wherein (i) the right and left edges comprise respective right and left tubular sleeves, the right tubular sleeve having the right elongated rod received therein, and the left tubular sleeve having the left elongated rod assembly received therein with a handle opening being provided in the left tubular sleeve proximate a longitudinal midpoint thereof, the elongated handle proximate the distal end extending through the handle opening, and wherein the first and second stakes each include a cylindrical portion, the cylindrical portion being received over one of the first and second ends of the right elongated rod.

US Pat. No. 10,336,536

SYSTEM AND DEVICE FOR YARD WASTE COLLECTION

1. A bag fitting device for storing collected yard waste, comprising:a. A screen having a first side and second side positioned oppositely to said first side;
b. A border positioned about said screen, said border enclosing said screen, said border having a first side, a second side positioned perpendicular to said first side, a third side positioned oppositely to said first side and perpendicular to said second side, and a fourth side positioned oppositely to said second side and perpendicular to said first side and said third side;
c. A primary hole positioned within said screen, said primary hole having a first raised border on said screen first side and a second raised border on said screen second side;
d. At least two secondary holes positioned within said screen, said bag fitting device being fittable within an opening of a “pliable container”, said opening of said pliable container being closable about said bag fitting device;
e. A collection device for collecting yard waste; and
f. A mulching device connected to said collection device,
Whereby said bag fitting device is connected to said mulching device, said bag fitting device is connectable to a bag for final collection of yard waste collected by said collection device said bag being movable with said collection device as said collection device collects said yard waste, wherein said bag fitting device substantially inflates said bag.

US Pat. No. 10,336,534

SELF-CLEANING TANK

Spokane Industries, Spok...

1. A container comprising:a tank for holding a product, the tank comprising:
a top surface;
a bottom surface opposite the top surface, the bottom surface having a perimeter and defining a first plane, and the bottom surface having a non-zero slope relative to a horizontal plane;
a vertical wall fixed to the perimeter of the bottom surface and between the bottom surface and the top surface, the bottom surface extending substantially around a perimeter of the vertical wall;
an aperture arranged in the vertical wall of the tank, a portion of the aperture arranged at the perimeter of the bottom surface of the tank and adjoining with the bottom surface; and
a scraper blade assembly rotatably coupled to the bottom surface of the tank, the scraper blade assembly comprising a blade having a rotational path in a second plane parallel to the first plane, the blade comprising:
a first leading surface opposite a first trailing support structure, the first leading surface having a curvilinear shape spanning a first portion of the blade;
a first scraping member attached to a first end of the first portion of the blade;
a second leading surface opposite a second trailing support structure, the second leading surface having the curvilinear shape spanning a second portion of the blade;
a second scraping member attached to a second end of the second portion of the blade; and
one or more bottom scraping members arranged on the first leading surface and arranged on the second leading surface respectively to contact the bottom surface of the tank;
wherein when the blade is rotatably displaced in the second plane,
the one or more bottom scraping members maintain contact with the bottom surface of the tank,
the curvilinear shape of the first leading surface and the curvilinear shape of the second leading surface of the blade displaces solids deposited on the bottom surface of the tank in a direction towards the vertical wall of the tank, and
at least a portion of the first scraping member and at least a portion of the second scraping member extend through the aperture when the first scraping member and the second scraping member pass by the aperture to displace the solids deposited on the bottom surface of the tank through the aperture to clean the tank.

US Pat. No. 10,336,533

COLLAPSIBLE PARTICULATE MATTER CONTAINER

Halliburton Energy Servic...

1. A bulk storage container, comprising:a collapsible frame defined by a rigid upper support structure, a rigid lower support structure, a first support member, and a second support member;
a pair of tracks formed along opposite sides of the lower support structure, wherein a first end of the first support member is coupled to a first end of the upper support structure and a second end of the first support member is coupled to a first track of the pair of tracks, wherein a first end of the second support member is coupled to a second end of the upper support structure and a second end of the second support member is coupled to a second track of the pair of tracks, wherein the first support member and the second support member transition between an expanded position and a collapsed position by sliding the second end of the first support member and the second end of the second support member horizontally along the pair of tracks, and wherein the first support member and the second support member extend to a fully vertical position in the expanded position;
an actuator coupled to the first support member at one end;
a storage sack having an upper portion coupled to the upper support structure and a lower portion coupled to the lower support structure, the lower portion being a conical taper-shaped, wherein the upper portion of the storage sack is formed of a plurality of connected panels, wherein the plurality of panels are at least one of one or more rigid panels and one or more semi-rigid panels.

US Pat. No. 10,336,532

PACK FOR PREPARING FOOD OR BEVERAGE PRODUCTS

Nestec S. A., Vevey (CH)...

1. A pack for preparing a food or beverage product from one or more ingredients, the pack comprising:an insert comprising at least one primary fluid inlet and a dispensing outlet, the at least one primary fluid inlet comprising at least an aqueous fluid injection inlet and at least a gaseous fluid injection inlet; and
a container where the ingredient or ingredients are stored, wherein the aqueous fluid injection inlet and the gaseous fluid injection inlet communicate with the inner volume of the container; and
wherein an aqueous fluid and a gaseous fluid can respectively be introduced inside the container through the aqueous fluid injection inlet and the gaseous fluid injection inlet in order to prepare the food or beverage product, and wherein the dispensing outlet of the insert is configured to deliver the prepared food or beverage product as a free flow by gravity fall.

US Pat. No. 10,336,531

CAPSULE WITH STEEPING CHAMBER

2266170 Ontario Inc., Mi...

1. A capsule, for use in a machine for preparing consumable products from capsules, said machine having an injection system that includes at least one injection nozzle for injecting heated fluid into said capsule at a predetermined flow rate, said capsule comprising:a body defining an interior space with an opening;
a cover disposed over said opening, said cover being formed of a material that is heat shrinkable and resistant to tearing so as to shrink sufficiently around said at least one injection nozzle when said at least one injection nozzle pierces said cover and injects heated fluid into said capsule, to create a seal that allows pressure to build within said interior space beneath said cover up to a maximum pressure;
a filter disposed in said interior space to define a steeping chamber between said filter and said cover, said filter being formed of one or more materials that are sufficiently phobic to said heated fluid to cause said steeping chamber to fill with fluid without exceeding said maximum pressure; and
ingredients disposed in said steeping chamber for preparing a desired product,
wherein said filter is constructed and arranged to restrict a flow of the fluid through said filter to optimize extraction or infusion of said ingredients disposed within said steeping chamber.

US Pat. No. 10,336,529

POLYOLEFIN PACKING CONTAINER

TOYO SEIKAN GROUP HOLDING...

1. A polyolefin packing container having on the inner surface thereof an olefin resin layer that contains an ethylenebisfatty acid amide, wherein said ethylenebisfatty acid amide is bleeding in said inner surface in an amount of 12.5 to 200 mg/m2;wherein said ethylenebisfatty acid amide exhibits a plurality of endothermic peaks in a region of 40 to 130° C. on a heating-up profile (differential thermal curve) as measured by a differential scanning calorimetry;
wherein said ethylenebisfatty acid amide is partly ethylenebisoleic acid amide, and the rest is a compound represented by the following formula (1),
R1—CONH—CH2—CH2—NHCO—R2  (1)
wherein R1 and R2 may be the same or different, and are unsaturated or saturated aliphatic hydrocarbon groups having 14 to 22 carbon atoms, and either R1 or R2 in the above formula (1) is a saturated aliphatic hydrocarbon group; and
wherein at least 3% of said ethylenebisfatty acid amide is said half-saturated bisamide on condition that not less than 55% of said ethylenebisfatty acid amide is the ethylenebisoleic acid amide as measured by a liquid chromatography.

US Pat. No. 10,336,528

RAIL CAR RACK

Guardian Glass, LLC, Aub...

11. A kit, comprising:a rack adapted to hold a plurality of glass sheets, comprising:
a plurality of upright members that are spaced apart from one another, each of the upright members having upper and lower ends, the upright members being thicker at the respective lower ends compared to the respective upper ends and tapering in thickness along a height direction, and while the upright members are tapered so as to be thinner moving upwardly away from the ground, rear surfaces of the respective upright members which are opposite surfaces that are to support the glass sheets remain perpendicular to the ground and perpendicular to bottom surfaces of a plurality of base members throughout lengths of the upright members; and
the plurality of base members extending outwardly and generally perpendicularly from respective upright members, the base members having a thickness that increases moving outwardly from the upright members so as to form an acute or right angle between innermost surfaces of the upright members and uppermost surfaces of the base members; and
a plurality of bridges connectable at lower ends thereof to respective base members of the rack outside an outermost glass sheet provided to the rack, the bridges being arrangeable generally in parallel with the upright members and having upper ends extending to a height corresponding to upper ends of the upright members when the bridges are connected to the base members;
wherein the rack alone is self-standing as an L-frame rack, and wherein the rack is arrangeable back-to-back with another rack of the same type to form a mutually-supporting A-frame rack.

US Pat. No. 10,336,526

CHAMPAGNE SPRAYER

1. A sparkling wine sprayer, configured to spray a sparkling wine for recreational activities comprising:a bottle top sealing system, configured to provide an airtight seal to a sparkling wine bottle;
a quick release lever, pivotally and operatively coupled to the bottle top sealing system;
a tube for the sparkling wine to flow through, configured to have a nozzle section with a nozzle at one end, a lever section connected to the bottle top sealing system and a middle section between the nozzle section and the lever section;
a valve, positioned in the lever section of the tube to regulate flow of the sparkling wine through the tube; and
a trigger, mechanically connected to a sprayer body and operatively coupled to the middle section of the tube,
wherein the sprayer body is operated by actuating a mechanical control by a user.

US Pat. No. 10,336,525

PLANOGRAM DISPLAY FOR VERTICALLY ORIENTED PRODUCT CONTAINING DISPLAY CARDS

1. A nesting arrangement of a plurality of display cards comprising:each display card of the plurality of display cards in the nesting arrangement having a different height consisting of tall, medium and short heights;
each card having a protruding transparent package box containing a product for display and a top portion with means to engage a hook; and
each protruding transparent package box on each respective display card in the nesting arrangement having a differing location on its respective display card;
said arrangement of cards being nested and mounted on said hook, with the tallest display card in a rear position and progressively shorter display cards in front of said tallest display card, all of said cards are flush with each other, with the protruding transparent package boxes appearing stacked and visible together to a potential purchaser, whereby different products can be displayed side by side on a single hook, and an increased number of such display cards can be mounted on the same hook due to nesting of said display cards.

US Pat. No. 10,336,523

TAPE AND REEL PACKING MATERIAL

WINBOND ELECTRONICS CORP....

1. A tape and reel packing material for packaging a plurality of chips, comprising:a carrier tape, comprising a plurality of recesses, wherein the recesses are configured to receive the respective chips; and
a cover tape, attached to the carrier tape, wherein the cover tape comprises a plurality of restriction structures, and the restriction structures respectively are inserted into the recesses to restrict freedom of the chips, wherein each restriction structure comprises a peripheral restriction portion corresponds to a lateral surface of the chip,
wherein the restriction structure comprises a central restriction portion, the central restriction portion corresponds to a top surface of the chip to restrict the freedom of the chip in a first direction, the peripheral restriction portion restricts the freedom of the chip in a second direction and a third direction, and the first direction is perpendicular to the second direction and the third direction,
wherein the cover tape comprises a first attachment area, a second attachment area, and a restriction area, the first attachment area is parallel to the second attachment area, the restriction area is located between the first attachment area and the second attachment area, the restriction structures are formed on the restriction area, and the cover tape is attached to the carrier tape via the first attachment area and the second attachment area,
wherein the cover tape comprises a substrate, a tie-layer and an adhesive layer in the first attachment area and the second attachment area, the tie-layer is sandwiched between the substrate and the adhesive layer, the adhesive layer is adapted to attach the carrier tape, and only the substrate layer is in the restriction area.

US Pat. No. 10,336,522

PACKAGING

Consolidated Graphics, In...

1. A packaging, comprising:a first panel including a first end, a first central portion, and a second end, opposing perimeter side edges defining the first panel and extending between the first end and the second end, a first area having an inside surface and defined by the first end, the second end, and the perimeter side edges;
a second panel including a third end, a second central portion, and a fourth end, a second area defined by the third end and the fourth end, wherein the second end is coupled to the third end at a first fold line, and the first panel is substantially identical to the second panel; and
a first flap extending from a first side of the second central portion at a second fold line and a second flap extending from a second side of the second central portion at a third fold line, wherein when the first panel is folded toward the second panel about the first fold line and the first and second flaps are folded about the second and third fold lines, respectively, the first and second flaps engage the inside surface of the first area and couple the first panel and the second panel;
wherein when the first panel is folded toward the second panel about the first fold line the inside surface of the first end of the first panel is secured to the fourth end of the second panel; and
the first area and the second area are free of fold lines and flaps.

US Pat. No. 10,336,521

FILM FOR PACKAGING AND PACKAGING BAG

TOYOBO CO., LTD., Osaka ...

1. A film for packaging comprising a polyester-based resin film, whereinthe resin film comprises ethylene terephthalate in an amount of more than 50% by mol, based on 100% by mol of the total constituent units of the polyester,
the resin film comprises a polyester-based resin containing a monomer selected from neopentyl glycol, 1,4-cyclohexanedimethanol, and a combination thereof, which monomer is an amorphous component,
the total units derived from a polyhydric alcohol other than ethylene glycol and units derived from a polycarboxylic acid other than terephthalic acid is 13% by mol or more, based on 100% by mol of the total constituent units of the polyester,
the resin film has a density of 1.29 g/cm3 or more and 1.33 g/cm3 or less, and
the resin film has a twist holding angle of 400 degrees or more.

US Pat. No. 10,336,518

LOCKING DRINK CONTAINER

1. An apparatus comprising:a container;
a locking tray attached to the container and comprising:
an externally threaded cylinder defining a plurality of outward-facing notches about its base; and
an outer circumferential ring defining a plurality of inward-facing teeth about its circumference;
a cap assembly comprising:
an internally threaded cylinder;
a lock tab operative to slide radially towards and away from the internally threaded cylinder between an inward position and an outward position;
a spring-biased lock button translationally coupled to the lock tab and urging the lock tab towards its outward position when the spring-biased lock button is unpressed and positioning the lock tab in its inward position when the spring-biased lock button is pressed;
a stop tab operative to slide radially towards and away from the internally threaded cylinder between an inward position and an outward position; and
a spring-biased stop button translationally coupled to the stop tab and urging the stop tab towards its outward position when the spring-biased stop button is unpressed and positioning the stop tab in its inward position when the spring-biased stop button is pressed; wherein:
the lock tab is operative to engage one or more of the plurality of inward-facing teeth as the internally threaded cylinder is threadably engaged with the externally threaded cylinder with the spring-biased lock button unpressed; and
the stop tab is operative to engage one of the plurality of outward-facing notches with the internally threaded cylinder threadably engaged with the externally threaded cylinder and the spring-biased stop button pressed.

US Pat. No. 10,336,517

TAMPER-PROOF CONTAINER INSERT

1. In combination with a container having an upper end with an inside surface and a throat with an inside surface, comprising:a tamper-proof insert positioned in the throat of the container with the insert having upper and lower ends;
said insert being of the foam liner venting type;
a horizontally disposed retention lug ring mounted on said insert at said lower end of said insert;
said retention lug ring including a horizontally disposed base ring which is secured to said insert at said lower end of said insert; and
said retention lug ring having a plurality of radially spaced-apart retention lugs, having upper and lower ends, which extend upwardly and outwardly from said base ring whereby said upper ends of said retention lugs are in engagement with the inside surface of the container to prevent said insert from being removed from the container.

US Pat. No. 10,336,515

SHORT ROTATION SAFETY LOCK FOR CONTAINERS AND BOTTLE FOR SAID LOCK

1. A short rotation safety lock for a container having an opening surrounded by an annular protrusion, the short rotation safety lock comprising:an internal structure that fits into the opening of the container,
an external structure comprising a rotatable body rotating about the internal structure,
a rotation assembly linking the internal structure to the external structure and allowing the external structure to rotate about the internal structure;
mobile blocking members,
wherein the internal structure comprises:
a clamping frame configured to clamp the internal structure to the container, the clamping frame comprising grip fingers that are elastically deformable and capable of clamping to the annular protrusion of the container,
wherein the mobile blocking members act behind the grip fingers so as to release or hold them against the annular protrusion of the container:
a lock cap configured to forcibly fit in the opening of the container, the lock cap being linked to the clamping frame formed by the grip fingers that are alternated with intermediate spaces;
wherein the rotating assembly comprises a rotation limiter device that limits rotation movement of the external structure about the internal structure to a rotation capacity, and
wherein the rotation movement of the external structure determines the movement of the mobile blocking members between an active position behind said grip fingers and a passive position in said intermediate spaces.

US Pat. No. 10,336,514

ANGLED SPOUT ASSOCIATED WITH A TIMER FOR DISPENSING A CONTROLLED QUANTITY OF LIQUID COMPOSITION

1. A container comprising:a container body having a closed end and an open end;
a liquid composition contained in said container body, wherein when said closed end of said container body is resting on a level surface, said liquid composition has a phreatic surface;
a fitment body mounted to said open end;
a spout having an upstream spout inlet and a downstream spout outlet and a spout wall extending from said spout inlet to said spout outlet, wherein said spout inlet has a spout inlet invert and said spout outlet has a spout outlet invert and a straight line connecting said spout inlet invert and said spout outlet invert is oriented at an angle from about 10 to about 85 degrees above said phreatic surface;
an immobile partial obstruction in line with and upstream of said spout outlet;
a vent comprising an entrance spaced apart from said spout outlet and a vent wall extending from said entrance to an exit, wherein said exit is in fluid communication with said spout inlet; and
a timer engaged with said fitment body, wherein said timer comprises a closed system containing a fixed volume of timer liquid;
wherein said fitment further comprises a floor extending at least partially around said spout and outwardly away from said spout and a channel wall extending from said floor in a direction away from said spout inlet to define a drain-back channel between said spout and said channel wall, wherein said floor is sloped to said entrance or to a hole in fluid communication with said spout inlet.

US Pat. No. 10,336,513

LID HAVING A PRE-VENTING LID LEVER AND A SEAL ARM ASSEMBLY

IGNITE USA, LLC, Chicago...

1. A lid for a liquid container, the lid comprising:a base that is configured for removable attachment to a container, the base including one or more vent holes and a drink hole;
a lid lever pivotably attached to the base, the lid lever including one or more vent plugs that selectively open and close the one or more vent holes; and
a seal arm assembly pivotably attached to the base and pivotably movable about a pivot point, the seal arm assembly including a drink plug that selectively opens and closes the drink hole,
wherein the seal arm assembly includes a ball plunger located in a recess that is formed in, or is connected to, a ball element, and
wherein, beginning in a closed position, the lid lever is pivotably movable independently of the seal arm assembly to open the at least one vent hole before the lid lever contacts the seal arm assembly to open the drink hole.

US Pat. No. 10,336,510

DRINK BOTTLE WITH CONTROLLED OPENING

IGNITE USA, LLC, Chicago...

1. A drink bottle, comprising:a container;
a lid connected to the container, the lid including a lid housing;
a spout coupled to the lid housing and movable between a stowed configuration and a dispensing configuration, the spout defining a passageway in fluid communication with an interior of the container when disposed in the dispensing configuration; and
an actuator assembly movably connected to the lid housing, the actuator assembly comprising a release button and a latch operatively coupled to the release button and movably disposed within the lid housing between a first position, in which the latch is operatively coupled to the spout when the spout is disposed in the stowed configuration to retain the spout in the stowed configuration, and a second position, in which the latch is operatively uncoupled from the spout, such that the spout moves from the stowed configuration to the dispensing configuration, and wherein the latch moves from the first position to the second position responsive to actuation of the release button.

US Pat. No. 10,336,509

SLIDE AND LOCK PACKAGE WITH FILM SEALABLE TRAY

Sonoco Development, Inc.,...

1. A reclosable container comprising:a tray having two lateral sides and comprising a bottom wall, two laterally opposing side walls, a front wall and a rear wall;
the bottom wall having a periphery, the side walls, the front wall and the rear wall each extending upward from the periphery and terminating in a rim;
the bottom wall, the side walls, the front wall and the rear wall defines one or more compartment within the tray for holding a product or products;
the tray further comprising a flat, continuous top wall extending outwardly from the rim and adapted to accept a flexible film in sealing engagement therewith;
the tray further comprising a skirt extending downward from the top wall and a flange extending outwardly from the skirt;
the skirt defining a groove on either lateral side of the tray that extends inwardly from the skirt; and
a lid comprising a cover portion that covers the one or more compartments, two lid side walls extending downward from the cover portion and a lid side flange extending laterally outward from each of the lid side walls;
each lid side wall forming an inwardly extending rib, each rib adapted to slide axially within a corresponding groove in the tray; wherein
the lid is moveable in a sliding fashion relative to the tray between a fully closed position in which the cover portion completely covers the one or more compartments and an open position in which the cover portion does not completely cover the one or more compartments.

US Pat. No. 10,336,508

RESEALABLE COVER FOR CONTAINERS

1. A cover for use in sealing a container that has a side wall with an upper rim; said cover comprising:a base having an upper end, a lower end, and an inner side surface that extends between the upper end and the lower end, wherein the inner side surface bounds and defines an opening; wherein the opening is adapted to provide access to a top end of a container with which the cover is selectively engaged;
a first channel defined in the lower end of the base; wherein the first channel is adapted to be complementary to an upper rim of the container and receives the upper rim of the container therein;
a first sealing member provided on the upper surface of the upper end of the base; wherein the first sealing member is vertically aligned with the first channel;
a lid having a top wall and a side wall circumscribing the top wall; wherein the lid is movable between an open position and a closed position; and when the lid is in the closed position, access to the opening in the base is prevented; and when the lid is in the open position, access to the opening in the base is permitted; and
a second sealing member provided on a bottom surface of the lid; wherein the first sealing member and the second sealing member are vertically aligned with each other and with the first channel; and the first sealing member and second sealing member are engageable with each other when the lid is moved to the closed position; and
wherein the first sealing member is a second channel and the second sealing member is a protrusion; and the protrusion is complementary to the second channel; and when the lid is moved to the closed position, the protrusion is received in the second channel.

US Pat. No. 10,336,507

PLASTIC CLOSURE WITH ENHANCED PERFORMANCE

Closure Systems Internati...

1. A plastic closure, comprising:a closure cap having a top wall portion, and an annular skirt portion depending from said top wall portion and extending around an axis,
said skirt portion of said closure cap having an internal thread formation for threaded engagement with an external thread formation of an associated container,
wherein said internal thread formation is configured to exhibit a variation in retention force which decreases in a direction away from said top wall portion of said closure cap when engaged with an external thread formation of an associated container, said internal thread formation being configured to define a plurality of thread profiles, including a thread profile having a relatively large cross-sectional area viewed in a plane containing the axis positioned closer to said top wall portion than another one of said thread profiles having a relatively small cross-sectional area,
wherein at least a portion of said thread formation has a continuously varying thread profile cross section, including a continuously varying depth in said thread profile extending at least 180° about a circumference of said closure cap over which the depth in said thread profile decreases in a direction away from said top wall portion.

US Pat. No. 10,336,504

STORAGE DEVICE WITH INFINITELY ADJUSTABLE STORAGE DIVIDER SYSTEM

Ford Global Technologies,...

1. A storage device, comprising:a sidewall defining a storage compartment, said sidewall including a guide track wherein said guide track extends continuously along said sidewall and includes radiused corners;
a hub held in said storage compartment, said hub including a plurality of hinge keys; and
a plurality of telescoping panels extending between said hub and said sidewall and dividing said storage compartment into individual chambers, wherein each panel of said plurality of panels includes a guide roller that is captured in and follows said guide track.

US Pat. No. 10,336,501

POLYGONAL CONTAINERS HAVING A LOCKING BOTTOM AND BLANKS AND METHODS FOR FORMING THE SAME

WestRock Shared Services,...

1. A blank for forming a polygonal container, the blank comprising:a plurality of side panels comprising a first side panel and a second side panel;
a corner panel connected to the first side panel and the second side panel by fold lines;
a bottom panel extending from the first side panel; and
an engagement member defined on bottom panel, the engagement member configured to engage an interior surface of the corner panel to prevent movement of the corner panel relative to the first and second side panels when the container is formed from the blank;
wherein the bottom panel comprises a first bottom panel extending from a bottom edge of the first side panel, and wherein the plurality of side panels further comprises a third side panel and a fourth side panel, said blank further comprising:
a second bottom panel extending from a bottom edge of the second side panel;
a third bottom panel extending from a bottom edge of the third side panel; and
a fourth bottom panel extending from a bottom edge of the fourth side panel,
wherein the first bottom panel, the second bottom panel, the third bottom panel, and the fourth bottom panel are configured to define a locking slot and a locking tab that is insertable into the locking slot to form a portion of the bottom wall of the container;
wherein the first bottom panel defines a locking indentation, the locking indentation at least partially defining the locking slot, and the fourth bottom panel defines the locking tab and a pair of shoulder joints extending from the locking tab, the pair of shoulder joints configured to abut the locking indentation when the locking tab is inserted into the locking slot;
wherein each of the shoulder joints comprises a shoulder edge that extends between the locking tab and a respective angled side edge.

US Pat. No. 10,336,500

TRAY FOR HOLDING A FOOD PRODUCT

Graphic Packaging Interna...

1. A tray for holding a food product, the tray comprising:a plurality of panels that extend at least partially around an interior of the tray, the plurality of panels comprises a bottom panel, a side panel foldably connected to the bottom panel, and an end panel foldably connected to the bottom panel;
a reinforcing structure comprising a first reinforcement panel foldably connected to at least one panel of the plurality of panels, and a second reinforcement panel foldably connected to the first reinforcement panel, the reinforcing structure forms a hollow rim defining an empty space between the first reinforcement panel and the at least one panel; and
a gusset panel foldably connected to the side panel, the gusset panel and the end panel at least partially overlapping on another,
the tray comprising paperboard.

US Pat. No. 10,336,498

CONTAINER WITH IMPROVED PUNCTUREABILITY

Printpack Illinois, Inc.,...

1. A container comprising:a substantially circular base;
a frustoconically shaped wall extending from an edge of the base and defining a cavity therein; and
a stacking shoulder which intersects and extends laterally from the wall, opposite the base;
wherein the base comprises an outer support structure surrounding an inwardly sloping continuous puncture region, the outer support structure being positioned from 0.5mm to 10.0 mm from the edge of the base and having a height of from 0.5 mm to 5.0 mm, relative the edge of the base, to increase the punctureability of the base,
wherein the inwardly sloping continuous puncture region extends from the outer support structure to a flat area extending radially from a center of the base, the flat area having a width from 5.0 to 10.0 mm,
wherein the outer support structure comprises a sidewall and the base comprises an annular wall extending between the sidewall of the outer support structure and the edge of the base, the annular wall extending completely along a plane parallel to a plane in which the flat area extends completely, and
wherein the inwardly sloping continuous puncture region has a constant slope at an angle (?) relative to a lateral axis at a bottom of the outer support structure which is greater than zero.

US Pat. No. 10,336,496

BEVERAGE GLASS AND BEVERAGE GLASS ASSEMBLY

STACKED WINES LLC, Newpo...

1. An assembly comprising:a first beverage container comprising:
a first vessel body comprising:
a first base having a first perimeter;
a first side wall connected to said first base; and
a first rim defined on said first side wall distal to said first base,
a first lid having a first seal region, said first seal region removably attached to an upper surface of said first rim, wherein said first seal region contacts and releasably engages an adhesive located between said first lid and said upper surface of said first rim; and
a second beverage container comprising:
a second vessel body comprising:
a second base having a second perimeter;
a second side wall connected to said second base; and
a second rim defined on said second side wall distal to said second base, wherein said first beverage container is releasably engaged by said second base of said second beverage container such that said first lid of said first container is interposed between said first rim of said first container and said second base of said second container; and
a second lid having a second seal region, said second seal region removably attached to said second rim; and
a cover that encloses said first beverage container and said second beverage container, said cover comprising an opening device that when manually operated provides access to at least one of said first beverage container and said second beverage container.

US Pat. No. 10,336,495

CONTAINER COMPRISING A SINGLE-PIECE HEAD SECTION

KOCHER-PLASTIK MASCHINENB...

1. A container, comprising:a container body capable of receiving a fluid;
a neck section being connected to said container body and having a dispensing opening at a free end of said neck section capable of dispensing the fluid from said container body;
a head section being removably connected to said neck section by a separating region and releasably sealing said dispensing opening closed; and
a movable sleeve section being coupled to said neck section and being actuatable to remove said head section from said neck section by releasing said separating region to open said dispensing opening, said movable sleeve section being movable from an unactuated state in which said dispensing opening is closed to an actuated state in which said separating region is released and being guided by being at least partially in contact with a guide path that is part of said head section, said guide path being formed on an outside of a ring collar surrounding said head section and extending between said separating region and an annular groove on said head section, said ring collar having an axial extension with a length of said annular groove measured on a smallest diameter size thereof.

US Pat. No. 10,336,494

COMPOSITE CONTAINER

1. A composite container combining a synthetic resin container body and a paper tube, wherein:the container body having a bottle shape including a tube-shaped base part having a bottom end edge rising up from an outer circumferential edge of a bottom part to a top end edge of the base part and connected to a mouth part via a shoulder part constricting in radius upwards;
the paper tube being provided over an outer circumferential surface of the container body extending between the top end edge to the bottom end edge;
at least a top end edge inner circumferential surface and a bottom end edge inner circumferential surface of the paper tube being adhered without adhesives to the outer circumferential surface of the base part of the container body, adherence of the paper tube to the container body being effectuated by disposing the paper tube in a mold and biaxial stretch blow shaping a preform into the container within the mold with a liquid as a pressurized medium; and
wherein the paper tube is a curled up rectangular piece of paper having at least one protrusion formed on one end edge of the piece of paper in the circumferential direction and inserted into at least one slit formed on the other end edge of the piece of paper in the circumferential direction.

US Pat. No. 10,336,492

SEALING JAWS FOR BAGGING APPARATUS

DYCO, INC., Bloomsburg, ...

1. A sealing jaw for use with a bagging apparatus comprising:a removable jaw having a guide/retention member selectively releasable in a first direction from a jaw holder;
the jaw holder comprising:
a retainer assembly having a release member movable between a first position for securing the guide/retention member therewith, and a second position for releasing the guide/retention member therefrom; and
wherein in response to a force being applied to the release member in a direction away from the jaw holder opposite the first direction urging the release member toward the first position, a dog is urged into engagement with the guide/retention member;
wherein in response to a force being applied to the release member in a direction toward the jaw holder in the first direction urging the release member toward the second position, the release member urging the dog into disengagement with the guide/retention member.

US Pat. No. 10,336,490

TAPING MACHINE FOR ATTACHING INSULATION TAPE TO OUTER PERIPHERAL SEALING PART OF BATTERY CELL

LG Chem, Ltd., Seoul (KR...

1. A taping machine for attaching an insulation tape only to a to-be-insulated portion set along an outer peripheral portion of a battery cell, comprising:a taping part configured to apply a portion of the insulation tape to a side surface of the battery cell included in the to-be-insulated portion;
a finish processing part configured to finish an attachment of the insulation tape to the battery cell;
a conveyor configured to convey the battery cell to the taping part and the finish processing part in order; and
a tape supply part configured such that the insulation tape is wound therearound and is moved while being unwound in a direction corresponding to a moving direction of the conveyor;
wherein the taping part is configured to cut the insulation tape, and is configured to apply the cut insulation tape to the side surface of the battery included in the to-be-insulated portion; and
wherein the finish processing part is configured to press the portion of the insulation tape applied to the side surface of the battery cell and to press remaining unattached portions of the insulation tape onto an upper surface of the battery cell included in the to-be insulated portion so that the insulation tape is attached to an entire to-be-insulated portion.

US Pat. No. 10,336,489

PACKAGING MACHINE

AUTOMATED PACKAGING SYSTE...

1. An apparatus for making packages, comprising:an indexing mechanism configured to receive a web of connected bags;
a blower configured to blow air into an opening of a bag;
an engagement device, the engagement device comprising:
a first pair of grippers for gripping a first ply of the bag;
a second pair of grippers for gripping the first ply of the bag, wherein the second pair of grippers are spaced apart from the first pair of grippers;
a third pair of grippers for gripping a first side edge of the bag;
a fourth pair of grippers for gripping a second side edge of the bag, wherein the third pair of grippers and fourth pair of grippers are movable relative to each other;
wherein movement of the third and fourth pair of grippers toward each other when each of the pairs of grippers is gripping the bag causes the first and second side edges of the bag to move toward each other to form the opening of the bag into a rectangular opening;
a sealing member configured to seal the opening of the bag.

US Pat. No. 10,336,487

PROCESS FOR THE MANAGEMENT OF A FLOW OF MATERIAL ALONG A RESPECTIVE PLANT

PULSAR S.R.L., Castel Ma...

1. A process for managing a flow of material along a direction of feed of a plant for making and packing articles obtained from semi-finished products in the form of elongate pieces or elements made of paper-based material, comprising:packing the articles to form respective packs containing one or more of the articles housed in a respective container or wrapper, the plant used by the process including a plurality of plant sections including at least each of a rewinding machine that supplies the semi-finished products, an apparatus for making and packing the articles from the semi-finished products, an accumulation section, and a control unit,
the apparatus for making and packing the articles located downstream from the rewinding machine along the direction of feed and having working sections along one or more working lines for making and for packing the articles, respectively,
the accumulation section configured for accumulating or storing the semi-finished products, from which the apparatus for making and packing the articles receives the semi-finished products and which in turn receives the semi-finished products from the rewinding machine that supplies the semi-finished products, and
the control unit, which includes an electronic processing system controlled through corresponding program instructions, being configured to
detect filling values representative of a filling level of the semi-finished products in the accumulation section,
provide a continuous comparing of the filling values with a predetermined filling level, and
generate operating instructions for varying a speed of the apparatus for making and packing the articles, which is located upstream of the accumulation section, in such a way as to vary continuously a number of articles processed per unit of time by the apparatus for making and packing the articles, so that the semi-finished products in the accumulation section are kept at the predetermined filling level.

US Pat. No. 10,336,485

BINDING MACHINE FOR GARDENING

MAX CO., LTD., Tokyo (JP...

1. A binding machine for gardening comprising:a binding machine main body;
a magazine that is attached to the binding machine main body and loaded with a tape; and
a clincher arm that is rotatably attached to the binding machine main body and is configured to draw the tape out of the magazine and bind an object to be bound which is wound by the tape, the clincher arm including a lock plate, a tape catch, and a tape plate, the lock plate being rotatable and urged by a coil spring, the tape catch being rotatable and urged toward the tape plate by a torsion spring, and the tape plate facing the tape catch, wherein
the magazine includes
a housing in which the tape is loaded,
a boss that is provided at a center of the housing and that is configured to support a reel around which the tape is wound, the boss being a cylindrical body having a smaller diameter than an inner diameter of the reel, and including a notch portion formed in a wall portion,
a shaft internal to the boss, and
an abutting member defining a lever that is pivotably attached to the boss by the shaft at a proximate end, defining a leading edge portion at a distal end that abuts against an inner peripheral surface of the reel, and defining an inclined surface inclined from a top surface toward a bottom surface opposite the top surface at an inclination angle in a range of 30-60 degrees, and
wherein
the abutting member includes a hook-shaped engaging portion projecting from the bottom surface,
the housing includes an engagement hole, and
the engaging portion sliding in the engagement hole defines the movable range of the abutting member.

US Pat. No. 10,336,483

APPARATUS AND METHOD TO FORM A CUSHIONED PACKAGE HAVING AN INNER BAG WITHIN AN OUTER BAG

Amazon Technologies, Inc....

1. A packaging device for creating a package for a product, the package including an inner bag surrounded by an outer bag that operates as an air cushion for protecting the product in the inner bag, the packaging device comprising:a hopper for storing the product and for selectively releasing predetermined amounts of the product from the hopper;
a filling tube having a body, a first end coupled to the hopper and a second end opposite the first end for dispensing the product into the inner bag after releasing of the product from the hopper;
a first guide for positioning a first multi-layer material about the body of the filling tube, and in response to being processed by the packaging device, the first multi-layer material forming the inner bag for containing the product;
a second guide for positioning a second multi-layer material about the filling tube, and in response to being processed by the packaging device, the second multi-layer material forming the outer bag;
an edge sealer for creating a first seam for joining opposing sides of at least one of the first multi-layer material or the second multi-layer material for forming at least one tube of material with the first seam;
an air dispenser for injecting air and for creating air pressure within the outer bag without pressurizing the inner bag;
sealing jaws located proximate to the second end of the filling tube, the sealing jaws for sealing the inner bag and the outer bag together with a second seam for maintaining the air pressure within the outer bag and for securing the product within the inner bag; and
a cutting blade for separating the package from the first and second multi-layer materials.

US Pat. No. 10,336,482

SYSTEM, METHOD AND APPARATUS FOR PRESERVING AND CAPPING TUBES

GENERAL ELECTRIC TECHNOLO...

1. A system for preserving and capping tubes, comprising:a compressed air reservoir for storing compressed air;
a preservative reservoir containing a supply of a preservative;
a nozzle in fluid communication with the compressed air reservoir and the preservative reservoir for injecting the preservative into the interior of a tube; and
a capping device configured to insert a cap onto the end of the tube.

US Pat. No. 10,336,478

VISCOUS-MATERIAL FILLING METHOD

KAGA WORKS CO., LTD., Na...

1. A method for transferring a viscous material from a container into a dispensing syringe to fill the dispensing syringe, the dispensing syringe having a main body portion, a first open end and a second open end, the first open end comprising a discharge port smaller in inner diameter than the main body portion,the syringe further including a plug configured to permit gas flow in only one direction, the plug being inserted into the syringe such that the plug divides a chamber within the syringe into a first sub-chamber in communication with the discharge port and a second sub-chamber in communication with the second open end of the syringe;
the method comprising:
inserting a rod into the syringe from the second open end of the syringe such that the rod engages the plug;
applying a force to the plug via the rod in a direction of the first open end; and
with the force being applied to the plug, extruding the viscous material from the container and through the discharge port into the first sub-chamber of the syringe.

US Pat. No. 10,336,477

SYRINGE PACKAGING SYSTEM FOR HOSPITAL PHARMACIES

1. A system for semi-automated filling of syringes with medicines from containers, said syringes being of various sizes and types all having a barrel, an annular flange encircling said barrel, a plunger slideably engaged in said barrel, and a flange at distal end of said plunger, and said plurality of containers of medicines being of various sizes and types, the system comprising:a programmable controller including software for controlling said system;
a container of medicine having an annular body and an aperture into said body for accepting a syringe nozzle;
a filling station, comprising:
a syringe loading station for loading of a syringe,
a container loading station for manual loading said container, said container loading station including a gripper for gripping said container; and
a plurality of arms for manipulating said syringe when in said filling position, said plurality of arms including at least a first arm and second arm both terminating in a forked end for engaging the syringe, each arm being independently servo-controlled and articulating along an axis, said first arm and said second arm being adapted to withdraw the plunger of said syringe to fill said syringe with medicine;
wherein said second arm terminates in one or more right-angle plates each having a transverse curvilinear notch defining said forked-end terminus.

US Pat. No. 10,336,476

METHOD FOR MONITORING A FILLED CONTAINER AND MONITORING SYSTEM FOR FILLED CONTAINERS

KRONES AG, Neutraubling ...

1. A method for monitoring a filled container which is conveyed on a conveyor, comprising:taking up the container by a carriage,
creating a spacing between the container and the conveyor, so that the entire weight of the container is retained by the carriage in a weighing region,
weighing the retained container in the weighing region using a load cell comprised by the carriage, wherein the carriage is controlled such that it takes up the container and guides it along the conveyor while measuring the weight of the filled container,
the carriage being driven by a linear motor.

US Pat. No. 10,336,475

FLEXIBLE PROPULSION SYSTEM

1. An apparatus comprising:a propulsion system for use on a spacecraft including:
at least one chemical thruster operable with a liquid propellant;
at least one electric thruster operable with a high atomic weight inert gas; and
a first quantity ‘n’ of identically sized pressurant tanks; wherein:
the propulsion system results from assembling a plurality of subassemblies, such that a first selectable number ‘e’ of the first quantity of identically sized pressurant tanks are manifolded together with the at least one electric thruster and loaded with the high atomic weight inert gas such that the at least one electric thruster is provided with the high atomic weight inert gas, and a second selectable number ‘c’ of the first quantity of identically sized pressurant tanks are manifolded together with the at least one chemical thruster and loaded with helium or other low atomic weight pressurant;
‘e’ is an integer;
c=n?e; and
‘e’ is less than ‘n’ and greater than zero.

US Pat. No. 10,336,474

METHOD AND DEVICE FOR DEFLECTION OF SPACE DEBRIS

1. A method for deflecting space debris comprising steps of:launching a thruster by means of a sounding rocket at a target altitude close to that of the one or more debris to be deflected, wherein the thruster comprises a combustion chamber and a nozzle, and the thruster is fixed to the tip of the sounding rocket with the nozzle pointing towards a launch direction of the sounding rocket;
generating, by the thruster, a combustion within the combustion chamber causing a downward thrust on the sounding rocket; and
emitting, from the nozzle of the thruster, a product of the combustion to generate a gas cloud above the sounding rocket and along a trajectory of the one or more debris.

US Pat. No. 10,336,473

BRAKE TEMPERATURE PREDICTION AND COOLING TIME FUNCTIONALITY

Airbus Operations Limited...

1. An aircraft comprising:a torque sensor configured to measure torque reacted by a brake during a braking event;
a wear sensor configured to measure a wear state of the brake;
an environmental sensor configured to measure at least one ambient condition of an environment of the brake; and
a brake cooling prediction apparatus configured to predict a brake cooling period following a braking event involving the brake, when measured values of a temperature of the brake are not available at least in respect of a time period including the braking event and a time of predicting the brake cooling period, the brake cooling prediction apparatus comprising:
a non-transitory memory storing information relating to a thermal behavior of the brake; and
a controller configured to:
receive a torque measurement from the torque sensor;
receive a wear measurement from the wear sensor;
receive an ambient condition measurement from the environmental sensor; and
predict a cooling period required for the brake to reach a predetermined temperature following the braking event, based on the received torque measurement, the received wear measurement, the received ambient condition measurement, and the stored information relating to the thermal behavior of the brake.

US Pat. No. 10,336,472

MOTOR HEALTH MANAGEMENT APPARATUS AND METHOD

The Boeing Company, Chic...

1. An apparatus comprising:a sensor system for an aircraft; and
a controller that monitors a first group of motor parameters and a second group of external bias parameters in sensor data generated by the sensor system in which the first group of motor parameters is for an environment affected by operation of a motor in the aircraft and the second group of external bias parameters modifies an effect of the first group of motor parameters in identifying a health of the motor; identifies the health of the motor based on the first group of motor parameters, the second group of external bias parameters, confidence factors for sensors in the sensor system, a phase of operation of the motor, and a phase of flight of the aircraft; and controls operation of the motor based on the health of the motor identified.

US Pat. No. 10,336,467

AIRCRAFT TURBULENCE DETECTION

Safe Flight Instrument Co...

1. An aircraft warning method comprising:receiving the aircraft's vertical speed;
receiving, from a motion sensor integrated with the aircraft, at least one of the aircraft's vertical acceleration rate and a rate of change of a parameter indicative of the aircraft's movement about an aircraft axis;
calculating a safe landing value based on the aircraft's vertical speed and at least one of the aircraft's vertical acceleration rate and the rate of change of the parameter;
comparing the safe landing value to a threshold value, wherein the threshold value varies with a height of the aircraft above touchdown; and
providing an aircraft warning when the safe landing value fails to meet the threshold value.

US Pat. No. 10,336,466

SYSTEM FOR EMULATING NAVIGATION SIGNALS

Garmin International, Inc...

1. A navigation system for emulating navigation signals for an aircraft, said navigation system comprising:a global-positioning system receiver configured to determine a geographic position of the aircraft;
a memory configured to store position data for at least one waypoint;
an emulation system configured to compare the geographic position of the aircraft with the position data of the waypoint and a navigation course to generate a composite navigation signal indicative of a cross track deviation between the aircraft and the navigation course; and
a wireless transmitter coupled with the emulation system, the wireless transmitter configured to wirelessly transmit the composite navigation signal to a course direction indicator having an integral converter unit for decoding the composite navigation signal into a control signal that drives an indicator needle of the course direction indicator.

US Pat. No. 10,336,464

AIRCRAFT PROPULSION ASSEMBLY WITH FIRE EXTINGUISHING SYSTEM

SAFRAN AIRCRAFT ENGINES, ...

1. An extinguishing system for extinguishing a fire which may break out in an engine and/or a nacelle surrounding the engine of an aircraft propulsion assembly, the extinguishing system comprising:a pipe in fluid communication with a cavity in the engine and/or a cavity in the nacelle;
an extinguishing agent supply configured to provide an extinguishing agent to the pipe; and
an air supply configured to provide ventilation air to the pipe, the ventilation air having a non-zero percentage of oxygen,
wherein the extinguishing system is configured to selectively discharge the extinguishing agent from the pipe into the cavity/cavities to extinguish a fire, wherein the extinguishing system is configured to discharge the ventilation air from the pipe into the cavity/cavities to ventilate the cavity/cavities, and wherein the air supply includes an electric ventilator fan designed to output the ventilation air at an air flow rate of between 1 and 500 g/s, said ventilator fan being configured to operate when the engine is not running.

US Pat. No. 10,336,463

AIRCRAFT STALL WARNING/PROTECTION WITH TIME-VARYING MAXIMUM ANGLE OF ATTACK SETTINGS FOR ICING CONDITIONS

1. For use in an aircraft including a deicer operative to deice in response to detected icing, a stall warning and/or protection system comprising:at least a first sensor configured to detect icing;
at least a second sensor configured to detect at least one parameter indicative of angle of attack; and
a computer, operatively coupled to the first sensor and second sensor, the computer being configured to apply a function dependent on the time at which the first sensor detects icing, the function adapting a maximum angle of attack parameter to track rate of deicing,
wherein the function is a time varying function, and the rate of deicing, to which the time varying function adapts the maximum angle of attack parameter, is defined at least in part by a stored deicing model that at least in part models deicing effect of the deicer.

US Pat. No. 10,336,455

DEPLOYABLE CLEARANCE PANEL SYSTEM, METHOD, AND ASSEMBLY FOR A MONUMENT WITHIN AN INTERNAL CABIN OF AN AIRCRAFT

The Boeing Company, Chic...

1. A monument configured to be positioned within an internal cabin of a vehicle, the monument comprising:a deployable portion, wherein the deployable portion is configured to move due to inertia of the deployable portion without being contacted from a non-deployed state into a deployed state in a direction that is away from a passenger seat that is aft of the monument when an acceleration of the monument meets or exceeds a predetermined threshold,
wherein the deployable portion comprises a deployable clearance panel within a monument wall assembly, wherein the clearance panel is configured to move from the non-deployed state into the deployed state in the direction that is away from the passenger seat that is aft of the monument due to the inertia of the deployable portion without being contacted when the acceleration of the monument meets or exceeds the predetermined threshold,
wherein the clearance panel comprises a first portion that is configured to pivotally secure to the monument wall assembly, and a second portion that is configured to couple to the monument wall assembly by at least one mechanism, and wherein the at least one mechanism is configured to allow relative motion upon acceleration of the monument that meets or exceeds the predetermined threshold due to the inertia of deployable portion without the monument being contacted.

US Pat. No. 10,336,454

PIVOT BIN BUCKET WITH SLOT FOR RECEIVING PIVOT AXLE

1. A bucket for use with an aircraft storage bin, the bucket comprising:a bottom and first and second opposing side walls extending upwardly from the bottom, wherein the first and second side walls each include a top edge, wherein the first side wall includes a first bracket that is received in a first recess defined in the top edge of the first side wall, wherein the first bracket includes an upper surface, an inner wall and an outer wall, wherein the inner wall has a closed top, wherein a first slot extends downwardly from the upper surface and is defined in the outer wall, wherein the first bracket includes a first opening defined transversely through the inner and outer walls, wherein the second side wall includes a second bracket that is received in a second recess defined in the top edge of the second side wall, wherein the second bracket includes an upper surface, an inner wall and an outer wall, wherein the inner wall has a closed top, wherein a second slot extends downwardly from the upper surface and is defined in the outer wall, wherein the second bracket includes a second opening defined transversely through the inner and outer walls, wherein the first slot is configured to receive a first pivot axle therein, and wherein the second slot is configured to receive a second pivot axle therein.

US Pat. No. 10,336,453

SYSTEM AND METHOD FOR PAYLOAD MANAGEMENT FOR UNMANNED AIRCRAFT

Elwha LLC, Bellevue, WA ...

1. A payload management system for an unmanned aircraft system providing an unmanned aircraft to carry payload comprising at least one payload segment on a mission, the payload management system comprising:(a) a carrier for payload carried by the unmanned aircraft; (b) a containment system to contain the payload; wherein the containment system comprises an inflatable pod attachable to and removable from the carrier by insertion of a head portion of the inflatable pod into a receptacle in the carrier and inflation of the inflatable pod to expand the head portion to prevent removal of the inflatable pod from the receptacle until the inflatable pod is at least partially deflated; and wherein the inflatable pod of the containment system is attachable to the exterior to of the unmanned aircraft and aerodynamic characteristics of a body of the pod outside of the receptacle and exterior to the unmanned aircraft are adjustable by selective inflation and deflation of the pod.

US Pat. No. 10,336,452

DRONE WITH NO EXTERNAL PROPELLER BLADES

1. A drone, comprising:a main housing unit, wherein the main housing unit comprises:
an upper shell;
a lower shell; and
an internal platform that connects the top shell to the bottom shell;
a plurality of conduits extending radially outward from the main housing unit;
a plurality of turbines located within the main housing unit, wherein each turbine faces radially outward and aligns with a corresponding conduit;
a plurality of arms extending outwardly from the main housing unit, wherein each arm is attached to the main housing unit by mating to a corresponding conduit;
a plurality of nozzles, wherein each nozzle is connected to a corresponding arm and comprises:
a cylindrical ring, wherein the cylindrical ring comprises an upper passage and an outer channel that extends along an inner circumference of the nozzle;
wherein the upper passage comprises an uppermost volume of space inside the nozzle directly adjacent to the outer channel, and wherein airflow may enter the upper passage through a junction and exit out of the outer channel; and
an open and closed portion of the upper passage.

US Pat. No. 10,336,451

COUPLING ASSEMBLY FOR A REMOVABLE PROPELLER

1. A propeller coupling assembly comprising:a propeller locking mechanism, the propeller locking mechanism comprising:
a shaft, the shaft coupled to a rotor;
a plate, the plate including an opening to receive the shaft;
a spring, the spring encircling the shaft, wherein the spring is coupled to the shaft at a first end and the spring is coupled to the plate at a second end; and
one or more pins, the pins extending from the shaft; and
a propeller hub structured to couple to the propeller locking mechanism, the propeller hub having:
an aperture formed by a first opening at a first end of the propeller hub, a second opening at a second end of the propeller hub, and an internal surface of the propeller hub connecting the first opening to the second opening;
one or more grooves, each groove formed on the internal surface of the propeller hub, wherein each groove includes a first opening at the first end of the propeller hub and a second opening at the second end of the propeller hub; and
one or more slots, each slot formed on the first end of the propeller hub.

US Pat. No. 10,336,450

ENHANCED NET PITCHING MOMENT MULTI-WING VTOL COMPACT PERSONAL AIRCRAFT

1. An aircraft capable of vertical takeoff and landing comprising:a fuselage;
a multi-wing assembly comprising:
a plurality of groups of wings wherein:
each group of wings comprises a plurality of parallel wings, wherein the wings are stacked and statically connected with a plurality of struts,
the plurality of groups of wings are arranged symmetrically about a point within the fuselage in a plane normal to the chords of the wings,
the wings of one group are parallel to the wings of any other group,
the plurality of groups of wings are statically connected with a plurality of struts,
the plane is bounded by the spans of the first wing of the first group of wings and the last wing of the last group of wings, and
a shape of the plane is square.

US Pat. No. 10,336,449

ENGINE INSTALLATION OF VERTICAL TAKE-OFF AND LANDING (VTOL) AIRCRAFT

SIKORSKY AIRCRAFT CORPORA...

1. A vertical take-off and landing (VTOL) rotor blown wing (RBW) aircraft, comprising:a fuselage;
RBWs extending outwardly from opposite sides of the fuselage;
nacelles supportively disposed on the RBWs; and
reversely oriented, axial flow engines disposed in each of the nacelles to generate mechanical energy for driving lift and thrust generating prop-rotor rotations, wherein each of the reversely oriented, axial flow engines includes:
an inlet disposed proximate to a trailing edge of the corresponding one of the wings;
one or more inlet ducts disposed to direct inlet air flowing along the corresponding one of the wings in a rearward direction toward the inlet,
an outlet disposed proximate to a leading edge of the corresponding one of the wings, and
one or more outlet ducts disposed to direct engine exhaust from the outlet along the corresponding one of the wings in the rearward direction, the orientation of the one of more outlet ducts being adjustable.

US Pat. No. 10,336,448

TILTWING MULTICOPTER WITH FOLDABLE AND NON-FOLDABLE PROPELLERS

Kitty Hawk Corporation, ...

1. An aircraft, comprising:a fuselage which includes a windshield and a top;
a starboard-side non-foldable outer propeller;
a port-side non-foldable outer propeller;
a starboard-side foldable inner propeller;
a port-side foldable inner propeller; and
a tiltwing, wherein:
the tiltwing is a single common wing to which the starboard-side non-foldable outer propeller, the port-side non-foldable outer propeller, the starboard-side foldable inner propeller, and the port-side foldable inner propeller are coupled to;
the starboard-side non-foldable outer propeller, the port-side non-foldable outer propeller, the starboard-side foldable inner propeller, and the port-side foldable inner propeller rotate at least some of the time when the tiltwing is in a vertical takeoff and landing position;
the starboard-side foldable inner propeller and the port-side foldable inner propeller are stowed at least some of the time when the tiltwing is in a forward flight position;
the tiltwing is coupled to the fuselage above and aft of the windshield and the tiltwing rotates about an axis of rotation, when rotating between the vertical takeoff and landing position and the forward flight position, that is higher than the aircraft's center of mass; and
the tiltwing includes a cutout such that the tiltwing aligns with the top of the fuselage when the tiltwing is in the forward flight position, including by having a first portion of a vertical stabilizer that is attached to the tiltwing and a second portion of the vertical stabilizer that is attached to the top of the fuselage align when the tiltwing is in the forward flight position.

US Pat. No. 10,336,447

FOLDING PROPROTOR GIMBAL LOCK AND BLADE LOCK MECHANISM

Bell Helicopter Textron I...

1. A gimbal lock mechanism for a rotor hub, the gimbal lock mechanism comprising:a cam member having a cuff lock lobe and a gimbal lock lobe, the cam member rotatable relative to a housing;
a rotor blade having a root end portion;
a first pin located on the root end portion of the rotor blade; and
an aperture located in the cuff lock lobe;
wherein the cam member is configured so that rotation can cause the cuff lock lobe to become adjacent to the root end portion of the rotor blade and at the same time causes the gimbal lock lobe to become adjacent to a gimbal and inhibit gimbaling of the gimbal.

US Pat. No. 10,336,446

DIRECTIONAL STIFFNESS BEARING SLEEVE ASSEMBLY FOR ROTOR SYSTEMS

SIKORSKY AIRCRAFT CORPORA...

1. A bearing sleeve assembly comprising:a rigid inner element having a non-circular cross-section including a cylindrical inner diameter bore and an outer surface that is non-cylindrical;
a rigid outer element spaced radially outwardly from the rigid inner element, the rigid outer element comprising a cylindrical member with a uniform cross-section that forms a ring with an inner-diameter surface and an outer-diameter surface, the outer element's inner-diameter surface and the non-cylindrical outer surface of the inner element defining a non-uniform annulus therebetween; and
an elastomeric core disposed between the rigid inner element and the rigid outer element within the non-uniform annulus, the elastomeric core having a first thickness at a first location and a second thickness at a second location, the first thickness being greater than the second thickness.

US Pat. No. 10,336,445

HIGH FLAPPING YOKE HUB ASSEMBLY USING A CYLINDRICAL ELASTOMERIC ATTACHMENT TO AVOID HOLES

BELL HELICOPTER TEXTRON I...

1. An apparatus comprising:an assembly comprising a first and a second rotor yoke, each comprising:
two longitudinal side portions interconnected by and spanning between two outboard portions at each longitudinal end of the rotor yoke to form an elongated loop about an axis of rotation of the rotor yoke, wherein a center portion of each longitudinal side portion comprises a solid cylindrical or solid oval build-up of material that is integral with the yoke and that accommodates a yoke hub clamp, wherein the two longitudinal side portions are free of apertures passing through the two longitudinal side portions;
a first lower and a first upper clamp assembly that are contoured to the solid cylindrical or oval build-up of material and that transfers torque from a mast to the first rotor yoke, wherein one or more first fasteners between the first lower and first upper clamps eliminate movement of the first rotor yoke along a lateral axis of the first lower and first upper clamp assembly; and
a second lower and a second upper clamp assembly that are contoured to the solid cylindrical or oval build-up of material and that transfers torque from a mast to the second rotor yoke, wherein one or more second fasteners between the second lower and second upper clamp eliminate movement of the second rotor yoke along a lateral axis of the second lower and second upper clamp assembly.

US Pat. No. 10,336,444

COMPOSITE STIFFENED RIGID PROPELLER SHAPED MAIN ROTOR HUB

SIKORSKY AIRCRAFT CORPORA...

1. A rotor, comprising:a blade retention cuff configured to receive a rotor blade;
a yoke coupled to the blade retention cuff;
an inboard bearing located in the interior of the yoke configured to restrain centrifugal force while enabling the yoke to pitch through an entire operating range; and
a rigid propeller hub configured to enclose at least a portion of the blade retention cuff and at least a portion of the yoke, the rigid propeller hub includes a hub arm having a generally circular cross-section that extends along a portion of the blade retention cuff.

US Pat. No. 10,336,443

RETRACTABLE AND DEPLOYABLE FLIGHT ROTOR SYSTEM

BELL HELICOPTER TEXTRON I...

1. An apparatus comprising:a shaft comprising a spiral spline along a length of the shaft;
a rotor comprising a blade extending from the rotor and a tubular hole extending into the rotor, the tubular hole comprising a spiral groove configured to mate with the spiral spline on the shaft, wherein relative rotation between the spiral spline and the spiral groove causes the rotor to linearly move along the shaft; and
a cam surface comprising a recession, wherein the blade nesting in the recession constrains rotation of the rotor about the shaft and allows linear movement of the rotor along the shaft.

US Pat. No. 10,336,441

DRONE

LG ELECTRONICS INC., Seo...

1. A drone, comprising:a plurality of propellers configured for creating a lift;
a power driving unit configured for providing a rotation power to each of the plurality of propellers;
a ground sensing unit configured for measuring a distance to a first region of the ground and a shape of the first region;
a controller configured for controlling the power driving unit to differentiate rotation ratios of the plurality of propellers based on the measured distance and shape in response to an input for landing at the first region; and
a variable leg provided to a bottom end of the drone, the variable leg configured to come into a contact with the ground on making the landing and maintain level according to a distance to the ground by withdrawing or inserting the variable leg,
wherein the variable leg comprises:
a first shaft;
a second shaft coupled with a bottom end of the first shaft to be withdrawn or inserted; and
a spring provided between the first shaft and the second shaft.

US Pat. No. 10,336,439

STEALTH DESIGN WITH MULTI-FACETED DIHEDRAL PLANFORM AND INSUFFLATION MECHANISM

1. A stealth craft including a multi-faceted dihedral planform extending in a direction from a front to a rear of the stealth craft, the planform comprising:a first set of facets followed by a second set of facets along the direction of the planform, each of the facets from the first and second sets being a substantially flat surface, each of the facets from the first and second sets being separated from adjacent facets by sharp straight edges,
insufflation slots configured for blowing a fluid, the insufflation slots extending in a direction transverse to the direction of the planform,
wherein the first and second sets of facets have an angle of incline that is ascending and descending, respectively, with respect to the direction of the planform, and
wherein the insufflation slots are provided in selected facets of the first and second sets of facets to insufflate the fluid to form a cushion along the multi-faceted dihedral planform for improving aerodynamics and stability.

US Pat. No. 10,336,438

ROTORCRAFT FLY-BY-WIRE CONTROL LAWS

Bell Helicopter Textron I...

1. A method of operating a rotorcraft comprising:receiving on a first control signal path a first command signal to change a first flight characteristic of the rotorcraft;
receiving on a second control signal path a second command signal;
feeding forward the first command signal to the second control signal path;
generating from the first command signal a first actuator control signal;
receiving the first actuator control signal at an actuator and using the actuator to drive a flight control device in order to change a first operating characteristic of the rotorcraft;
generating from the first command signal and the second command signal a second actuator control signal; and
receiving the second actuator control signal at a second actuator and using the second actuator to drive a flight control device in order change a second operating characteristic of the rotorcraft, wherein the change in the second operating characteristic of the rotorcraft at least partly offsets a coupled response to the change in the first operating characteristic of the rotorcraft.

US Pat. No. 10,336,437

METHOD TO MEASURE AIRCRAFT HIGH-LIFT SYSTEM BRAKE RESPONSE TIME

HAMILTON SUNDSTRAND CORPO...

1. A method for testing a component in a high lift system of an aircraft, the high lift system comprising a central power drive unit for moving high lift surfaces arranged at a wing through providing rotational power by means of a transmission shaft to a plurality of drive stations operably coupled with the high lift surfaces; which power drive unit is operatively coupled to a controller and comprises at least one electric motor coupled with a selectively activated brake; the method comprising:actuating the at least one electric motor for a predetermined period of time with all brakes in the system deactivated;
acquiring a sensor output of a sensor coupled with the controller during the actuating of the motor and determining a motion of at least one of the motor and the high lift surfaces based on the acquired sensor output;
activating a selected brake under test:
measuring an elapsed time until the selected brake has arrested the motion of at least one of the motor and the high lift surfaces;
determining if the that the elapsed time is less than a predetermined threshold value; and
generating a brake failure signal for the selected brake if the elapsed time exceeds the predetermined threshold value.

US Pat. No. 10,336,436

TORQUE AND THRUST CONTROL OF A PROPELLER

SIKORSKY AIRCRAFT CORPORA...

1. A method for controlling a propeller of an aircraft, comprising:receiving, with a processor, one or more signals indicative of commanded collective pitch of the propeller associated with a desired torque;
receiving, with the processor, one or more sensed signals from at least one sensor mounted to the aircraft, one or more sensed signals being indicative of propeller axial speed, propeller rotational speed, and air density;
estimating, with the processor, a propeller torque and propeller thrust from one or more of the propeller axial speed, the propeller rotational speed, and the air density;
determining, with the processor, information indicative of an error value between a desired torque and a measured torque in the propeller;
determining, with the processor, information indicative of a corrected pitch command in response to the determining of the error value;
combining, with the processor, the corrected pitch command with the propeller rotational speed into an adjustment solution, the propeller rotational speed being governed by a full authority engine controller;
providing, with the processor, the propeller with the adjustment solution, wherein providing the propeller with the adjustment solution includes changing an attitude of one or more propeller blades of the propeller while maintaining a constant rotational speed of the propeller;
receiving, with the processor, a subsequent error value between the desired torque and the measured torque in response to the providing of the adjustment solution.

US Pat. No. 10,336,435

EROSION RESISTANT BLADE AND BLADE COATING

SIKORSKY AIRCRAFT CORPORA...

1. An airfoil blade having a coating disposed on a leading edge thereof, the coating comprising a polyurethane, a polysiloxane, and a linking agent that promotes a connection between the polyurethane and the polysiloxane; wherein the polyurethane and the polysiloxane are in separate layers with the linking agent disposed between the polyurethane layer and the polysiloxane layer.

US Pat. No. 10,336,434

SINGLE-SHAFT AERIAL VEHICLE

GOERTEK TECHNOLOGY CO., L...

1. A single-shaft aerial vehicle, comprising a propeller and an aerial vehicle body, wherein the aerial vehicle body has a streamlined shape, a drive motor is provided in the aerial vehicle body, the drive motor is configured to drive the propeller to rotate and provide the aerial vehicle body with an ascending power, whereinthe single-shaft aerial vehicle further comprises a wing drive unit constituting part of the aerial vehicle body;
a ring-shaped wing extending out of the wing drive unit is provided at a central position of the wing drive unit, and the ring-shaped wing is movable horizontally under the drive of the wing drive unit;
when drag areas of the ring-shaped wing extending out of an outer circumference of the wing drive unit are the same in all directions, the single-shaft aerial vehicle maintains its current flying posture; and
when the ring-shaped wing moves toward a certain direction to increase the drag area extending out of the wing drive unit in the certain direction, and contracts into the wing drive unit in an opposite direction to reduce the drag area in the opposite direction, the single-shaft aerial vehicle changes its current flying posture.

US Pat. No. 10,336,433

FUSED POROGEN PROCESS FOR ACOUSTIC SEPTA FABRICATION

The Boeing Company, Chic...

1. A method for forming porous membranes within a multicellular frame for manufacturing a multicellular structure for acoustic damping in an aircraft, the method comprising:templating the multicellular frame with a fused porogen network so as to create a multicellular frame-porogen assembly;
applying a polymer into the fused porogen network of the multicellular frame-porogen assembly; and
removing the fused porogen network from the multicellular frame-porogen assembly resulting in polymeric septum membranes within the multicellular frame, and wherein the polymeric septum membranes are porous membranes having a thickness of about 1.0 mm to about 5.0 mm and wherein the porous membranes comprise a substantially continuous matrix having pores with a size less than about 15% of the thickness of the polymeric septum membranes.

US Pat. No. 10,336,432

LIGHTER THAN AIR BALLOON SYSTEMS AND METHODS

World View Enterprises In...

1. A lighter-than-air (LTA) high altitude balloon system comprising:a zero-pressure balloon (ZPB) configured to receive therein a first mass of LTA gas to provide a first upward lifting force to the balloon system;
a super-pressure balloon (SPB) configured to couple with the ZPB, the SPB comprising an interior volume configured to receive therein a second mass of LTA gas to provide a second upward lifting force to the balloon system; and
the SPB comprising a first valve configured to be opened and closed, wherein the first valve when opened allows for release of at least a portion of the second mass of LTA gas from the SPB through the first valve to a surrounding atmosphere to decrease the second upward lifting force, and the first valve when closed does not allow for release of the second mass of LTA gas from the SPB through the first valve to the surrounding atmosphere,
wherein the interior volume of the SPB is further configured, after release of the at least a portion of the second mass of LTA gas from the SPB, to receive therein a variable amount of ambient air from the surrounding atmosphere to provide a variable downward force to the balloon system.

US Pat. No. 10,336,431

OUTBOARD MOTOR

YAMAHA HATSUDOKI KABUSHIK...

1. An outboard motor that generates a thrust while using an internal combustion engine as a power source, the outboard motor comprising:a plurality of electric actuators;
a power-source voltage detector that detects a power-source voltage in the outboard motor;
a controller configured or programmed to include an event occurrence detector that determines that a voltage variation event has occurred only when both a power-source voltage detected by the power-source voltage detector becomes lower than a predetermined threshold value and the plurality of electric actuators are simultaneously driven; and
an event information recorder that records event information including a number of occurrences of the voltage variation event.

US Pat. No. 10,336,430

POD PROPULSION UNIT OF A SHIP

ABB Schweiz AG, Baden (C...

1. A pod propulsion unit of a ship, wherein the pod propulsion unit comprisesa pod housing arranged at least partly below a hull of the ship,
an electric propeller motor within a motor gondola of the pod housing for rotating at least one propeller, wherein the electric propeller motor having a rotor, a stator, an annular gap between the rotor and the stator, and gas channels extending through the rotor,
a closed cooling gas circuit, wherein the annular gap between the rotor and the stator and the gas channels extending through the rotor forms a part of the closed cooling gas circuit, and
a fan for circulating gas in the closed cooling gas circuit,
wherein the pod housing comprises a strut section between the hull of the ship and the motor gondola, and
wherein the stator of the electric propeller motor being fitted in a tubular section of the motor gondola of the pod housing of the pod propulsion unit,
wherein:
the closed cooling gas circuit comprising a feeding duct and a return duct for conducting gas between the pod housing and the hull of the ship,
the electrical propeller motor having a first motor end face and an opposite second motor end face,
the feeding duct extending between the return duct and the first motor end face of the electrical propeller motor, and
the return duct extending between the feeding duct and the opposite second motor end face of the electrical propeller motor,
the tubular section of the motor gondola having a circumferential outer surface that forms a part of the outer surface of the pod housing,
the stator of the electric propeller motor being cooled to water surrounding at least a circumferential section of the circumferential outer surface of the tubular section of the motor gondola through the wall of the tubular section of the motor gondola, and
a gas-liquid heat exchanger arranged in the closed cooling gas circuit between the feeding duct and the return duct for exchanging thermal energy between gas flowing in the closed cooling gas circuit and liquid circulating in at least one cooling liquid circuit.