US Pat. No. 10,138,825

CONTROL SYSTEM FOR INTERNAL COMBUSTION ENGINE, INTERNAL COMBUSTION ENGINE AND METHOD OF CONTROLLING INTERNAL COMBUSTION ENGINE

TOYOTA JIDOSHA KABUSHIKI ...

1. A control system for controlling an internal combustion engine provided with a fuel injector configured to inject fuel into a cylinder of an engine body,the internal combustion engine having a temperature region, wherein, during chemical reactions of the fuel in a compression stroke in a cycle where premixed gas is made to burn by compression ignition in the cylinder, a change of ignition delay time accompanying a rise in a cylinder temperature of the cylinder when the cylinder temperature is in the temperature region is smaller than when the cylinder temperature is out of the temperature region,
the control system comprising a processor configured to
control the fuel injector to successively inject primary fuel and secondary fuel into the cylinder to burn the premixed gas by compression ignition inside the cylinder, and
when a self ignition timing of the secondary fuel is earlier than a self ignition timing of the primary fuel injected at a predetermined crank angle due to the secondary fuel being injected at a crank angle at which the cylinder temperature is higher than an upper boundary temperature of the temperature region,
control a ratio of the secondary fuel in a total fuel injection amount of the primary fuel and secondary fuel to be lower than when the self ignition timing of the secondary fuel is later than the self ignition timing of the primary fuel injected at the predetermined crank angle due to the secondary fuel being injected at a crank angle at which the cylinder temperature is within the temperature region.

US Pat. No. 10,138,823

COMBUSTION ENGINE AIR INTAKE SYSTEM FOR MOTORCYCLE

KAWASAKI JUKOGYO KABUSHIK...

1. A combustion engine air intake system in a motorcycle,the combustion engine air intake system comprising:
a supercharger configured to be driven by power of a combustion engine of the motorcycle and compress intake air to be supplied to the combustion engine; and
an intake air control valve disposed on an upstream side of an impeller of the supercharger with respect to a flow direction of the intake air, and configured to adjust an amount of the intake air flowing into the impeller, wherein
the intake air control valve includes a plurality of valve bodies, the valve bodies being arranged in a circumferential direction, and
the intake air control valve is disposed so as to confront an inlet of the supercharger with respect to the flow direction of the intake air.

US Pat. No. 10,138,821

METHOD OF MAKING A THROTTLE BODY

GM GLOBAL TECHNOLOGY OPER...

1. A method of making a throttle body assembly, comprising:casting a main body portion having a passage there through and mounting features for pivotally mounting a throttle valve within the passage;
forming an annular spigot from a metallic material by 3 dimensional printing; and
welding the annular spigot to the main body portion.

US Pat. No. 10,138,820

ELECTRONIC THROTTLE CONTROL ASSEMBLY WITH DEFAULT AIRFLOW ADJUSTMENT PIN

Continental Automotive Sy...

1. An apparatus, comprising:a throttle control assembly, including:
a housing defining a central port;
a valve plate disposed in the central port and mounted on a shaft;
an actuator for controlling the rotation of the valve plate and the shaft;
at least one gear, the rotation of the at least one gear controlled by the actuator, the rotation of the at least one gear controls the rotation of the shaft;
an opening spring having a first end;
a closing spring having a first end separated from and abutting the first end of the opening spring; the opening and closing springs being operable for biasing the at least one gear, such that the valve plate is placed in a default flow position; and
at least one adjustment pin attached to the housing such that the at least one adjustment pin contacts only the first end of the opening spring;
wherein the adjustment pin is constructed and arranged to be movable to change a position of the first end of the opening spring causing a position of the abutting first end of the closing spring to change relative to the housing to adjust the default flow position of the valve plate.

US Pat. No. 10,138,818

INTERNAL COMBUSTION ENGINE CONTROL SYSTEM

HONDA MOTOR CO., LTD., T...

1. An internal combustion engine control system for controlling an internal combustion engine of a vehicle, comprising:an accelerator pedal operation amount detecting section for detecting an accelerator pedal operation amount of the vehicle by a driver;
a storage section that stores at least a first increase amount of a throttle opening degree with respect to an increase amount of an accelerator pedal operation amount as a first throttle opening degree characteristic and a second increase amount of a throttle opening degree larger than the first increase amount of a throttle opening degree with respect to the increase amount of an accelerator pedal operation amount as a second throttle opening degree characteristic;
an operating section for selecting the second throttle opening degree characteristic corresponding to an operation by the driver; and
a control section for controlling the throttle opening degree of the internal combustion engine, based on the first throttle opening degree characteristic or the second throttle opening degree characteristic and the detected accelerator pedal operation amount,
wherein the control section changes the first throttle opening degree characteristic to the second throttle opening degree characteristic on condition that an increase in the accelerator pedal operation amount larger than the predetermined operation amount by the driver occurs within a predetermined time after the selection of the second throttle opening degree characteristic by operation of the second operating section.

US Pat. No. 10,138,816

FUEL PUMPING UNIT

ROLLS-ROYCE PLC, London ...

1. A fuel pumping unit comprising:a low pressure centrifugal pump and a high pressure centrifugal pump, the low pressure centrifugal pump supplying fuel at a boosted pressure to the high pressure centrifugal pump for onward supply to a fuel metering unit;
a drive input that drives the low pressure centrifugal pump and the high pressure centrifugal pump, the drive input being a single input drive shaft from an engine accessory gearbox;
a gear arrangement that is operatively located between the drive input and the low pressure centrifugal pump and the high pressure centrifugal pump such that the low pressure centrifugal pump and the high pressure centrifugal pump are driven at different speeds by the drive input;
a positive displacement start pump that is driven by the drive input via the gear arrangement; and
a selector valve that is configured to selectably provide a high pressure mode, a low pressure mode, and a start mode,
wherein:
in the high pressure mode, the low pressure centrifugal pump supplies fuel at the boosted pressure to the high centrifugal pressure pump for onward supply to the fuel metering unit, the selector valve isolating the start pump or recirculating fuel between the start pump and the selector valve;
in the low pressure mode, the fuel supply from the low pressure centrifugal pump to the high pressure centrifugal pump is shut off such that the high pressure centrifugal pump runs dry and the low pressure centrifugal pump supplies fuel to the fuel metering unit, the selector valve isolating the start pump or recirculating fuel between the start pump and the selector valve; and
in the start mode, the low pressure centrifugal pump supplies fuel at the boosted pressure to the start pump for onward supply to the fuel metering unit, and the fuel supply from the low pressure centrifugal pump to the high pressure centrifugal pump is shut off such that the high pressure centrifugal pump runs dry.

US Pat. No. 10,138,815

SYSTEM AND METHOD FOR DIFFUSION COMBUSTION IN A STOICHIOMETRIC EXHAUST GAS RECIRCULATION GAS TURBINE SYSTEM

General Electric Company,...

1. A system, comprising:a turbine combustor comprising a first diffusion fuel nozzle, wherein the first diffusion fuel nozzle is configured to produce a diffusion flame;
a turbine driven by combustion products from the diffusion flame in the turbine combustor;
an exhaust gas compressor, wherein the exhaust gas compressor is configured to compress and route an exhaust gas from the turbine to the turbine combustor along an exhaust recirculation path; and
a catalyst heat and recovery system disposed along the exhaust recirculation path, wherein the catalyst heat and recovery system is configured to receive exhaust gas extracted from a plurality of exhaust gas extraction points, wherein the plurality of exhaust gas extraction points comprises the exhaust gas compressor, the turbine combustor, the turbine, or any combination thereof, wherein the catalyst heat and recovery system comprises:
a first catalyst unit disposed inside of the catalyst heat and recovery system, wherein the first catalyst unit is configured to adjust a composition of the exhaust gas; and
a first heat recovery unit disposed inside of the catalyst heat and recovery system and upstream of the first catalyst unit.

US Pat. No. 10,138,813

OIL BEARING WITH DRAIN SYSTEM, GAS TURBINE COMPRISING SUCH AN OIL BEARING

Siemens Aktiengesellschaf...

1. An oil bearing (OB) to support a rotor of a turbine, wherein said rotor extends along a rotor axis coinciding with a bearing axis (x), comprising:at least one oil bearing pad (BP) being lubricated by oil,
an oil sump (OS) suitable and located to collect said oil from said at least one oil bearing pad (BP) by forces of gravity,
a drain system of said oil sump (OS) adapted to conduct said oil away from said oil sump (OS),
wherein said drain system comprises at least three drain openings (OP1, OP2, OP3) of said oil sump (OS), comprising
a first drain opening (OP1) joining a first drain line (ODL) located between 4 o?clock and 5 o?clock according to said bearing axis (x),
a second drain opening (OP2) joining a second drain line (ODL) located between 5:30 and 6:30 o?clock,
a third drain opening (OP3) joining a third drain line (ODL) located between 7 o?clock and 8 o?clock,
wherein the clock positions refer to positions of the respective opening as seen when looking along the bearing axis with an upper-most position being a twelve o?clock position.

US Pat. No. 10,138,812

GAS TURBINE ENGINE BEARING CHAMBER SEALS

ROLLS-ROYCE plc, London ...

1. A gas turbine engine sealing air system comprising:a bearing chamber seal to prevent lubricant fluid loss from a fluid chamber, the sealing effected by ingress of sealing air;
an air vent duct coupled to the bearing chamber seal;
a starter air system of the gas turbine engine;
wherein the starter air system comprises a starter air turbine, a starter air valve and a starter air supply duct coupled therebetween,
a compressor of the gas turbine engine, the compressor being coupled to the sealing air system;
an ejector located within the air vent duct to pump sealing air from the bearing chamber seal and through the air vent duct; and
a first duct coupled between the starter air system and the ejector to provide motive fluid to the ejector during gas turbine engine starting, wherein
air from the starter air system is at a higher pressure than air available from the compressor during gas turbine engine starting,
the first duct is coupled only to the starter air supply duct and the ejector, and
the air supply duct is coupled only to the starter air turbine, the starter air valve and the first duct.

US Pat. No. 10,138,804

ROTARY INTERNAL COMBUSTION ENGINE

1. A method of controlling an air intake flow in a rotary engine having a rotor received in an internal cavity of an outer body and defining rotating chambers of variable volume, the rotary engine having a primary inlet port, a secondary inlet port, and an exhaust port, the secondary inlet port being in communication with the exhaust port through each of the rotating chambers throughout respective portions of a revolution of the rotor, the method comprising:positioning the secondary inlet port rearwardly of the primary inlet port and forwardly of the exhaust port along a direction of the revolution of the rotor;
positioning the secondary inlet port so as to be in communication with the exhaust port throughout portions of the revolution of the engine;
providing independently closable communications between an air source and the primary and secondary inlet ports;
controlling air intake flows between the air source and the primary and secondary inlet ports through the independently closable communications, including simultaneously allowing the air intake flow between the primary inlet port and the air source and allowing the air intake flow between the secondary inlet port and the air source, wherein exhaust gases of the engine are purged with the air intake flow between the secondary inlet port and the air source.

US Pat. No. 10,138,799

TWO-STAGE PRECOMBUSTION CHAMBER FOR LARGE BORE GAS ENGINES

Prometheus Applied Techno...

1. A two-stage precombustion chamber comprising:a first prechamber stage enclosing a first prechamber volume, the first prechamber stage comprising:
one or more first stage holes communicating between the first prechamber volume and a second prechamber volume;
a primary electrode disposed within the first prechamber volume; and
one or more ground electrodes disposed within the first prechamber volume and offset from the primary electrode to form one or more electrode gaps; and
a second prechamber stage enclosing the second prechamber volume, the second prechamber stage comprising:
one or more second stage holes communicating between the second prechamber volume and a combustion chamber volume; and
a fuel admission point configured to admit fuel into the second prechamber volume.

US Pat. No. 10,138,796

FERRITIC STAINLESS STEEL FOR AUTOMOTIVE EXHAUST SYSTEM, WHICH HAVE EXCELLENT CORROSION RESISTANCE AGAINST CONDENSATE, MOLDABILITY, AND HIGH-TEMPERATURE OXIDATION RESISTANCE, AND METHOD FOR MANUFACTURING SAME

POSCO, Pohang-si (KR)

1. A ferritic stainless steel, comprising: by wt %, C: more than 0 and 0.01% or less, Cr: 9 to 13%, Si: 0.5 to 1.0%, Mn: more than 0 and 0.5% or less, P: more than 0 and 0.035% or less, S: more than 0 and 0.01% or less, Ti: 0.15 to 0.5%, N: more than 0 and 0.01% or less, Sn: 0.05 to 0.5%, and Fe and unavoidable impurities as the remainder,wherein Sn concentrated at a surface part of the stainless steel is 10 times or more than Sn concentrated at a base part of the stainless steel,
the surface part extends from a surface of the stainless steel to a depth of 1 ?m and the base part is the remainder of the stainless steel, and
0.5 to 1.5% Sn is included in the surface part of the stainless steel.

US Pat. No. 10,138,788

MIXING STRUCTURE

HINO MOTORS, LTD., Hino-...

1. An exhaust system with a mixing structure having a lattice board axially with a number of flow passages and arranged halfway in the exhaust system, an additive added upstream of the lattice board being hit on flow passage walls in said lattice board for dispersion and facilitated vaporization of the additive, said mixing structure comprising said lattice board arranged obliquely in a flow changing portion halfway in the exhaust system where the exhaust gas flows curvedly so as to bisect an angle in said flow changing portion made by inflow and outflow directions of the exhaust gas from upstream of and discharged downstream of said flow changing portion, respectively, fins arranged on discharge sides of the flow passages in the lattice board and extending parallel to the outflow direction of the exhaust gas to guide flows of exhaust gas to the outflow direction from the flow changing portion, and an injector arranged to inject the additive in the outflow direction of said exhaust gas to an entry side of said lattice board such that the flow passage walls in said lattice board on which hit is the exhaust gas from upstream of said flow changing portion have rear surfaces on which hit is a spray of the additive from said injector,wherein any deviant flow of the exhaust gas outward of the curved direction by the flow passages in the lattice board is remedied and the flows of the exhaust gas discharging from the flow passages in the lattice board are guided to the outflow direction to provide an exhaust gas straightening effect by the flow passages and the fins.

US Pat. No. 10,138,782

MICROCHIP OXYGEN SENSOR FOR CONTROL OF INTERNAL COMBUSTION ENGINES OR OTHER COMBUSTION PROCESSES

KERDEA TECHNOLOGIES, INC....

1. A method of sensing oxygen in exhaust gases from a combustion process, comprising:simultaneously heating a substrate of a microchip oxygen sensor and passing current through a sensing circuit of the microchip oxygen sensor;
measuring a resistance of the oxygen sensing circuit;
wherein the heating the substrate comprising passing a first current through a heater pattern affixed to the substrate;
wherein the sensing circuit comprises:
a first electrode affixed to the substrate and having a first plurality of fingers forming a first comb;
a second electrode affixed to the substrate and having a second plurality of fingers forming a second comb, the second electrode disposed in spaced relation to the first electrode such that the first and second combs face each other;
a semiconducting layer disposed over the first and second electrodes so as form a physical semiconductor bridge between the first and second electrodes;
wherein passing the current through the sensing circuit comprises passing the current from the first electrode to the second electrode via the semiconducting layer;
wherein the microchip oxygen sensor is disposed in an exhaust gas stream during the heating, the passing current, and the measuring;
wherein the microchip oxygen sensor comprises the heater pattern, the first and second electrodes, and the semiconducting layer;
wherein the microchip oxygen sensor further comprises a porous dielectric protective layer covering the semiconducting layer, wherein the porous dielectric protective layer contains a catalytic precious metal;
wherein the substrate, electrodes, semiconducting layer, and protective layer are disposed in stacked order such that:
the first and second electrodes are in direct contact with the semiconducting layer;
the semiconducting layer is physically isolated from the substrate by electrodes;
the protective layer is physically isolated from the combs of the electrodes by the semiconducting layer;
wherein the method further comprises passing some of the exhaust gas through the protective layer to reach the electrodes.

US Pat. No. 10,138,771

OIL BYPASS STRUCTURE OF OIL COOLER

MAHLE FILTER SYSTEMS JAPA...

1. An oil bypass structure of an oil cooler comprising:a bypass passage within which oil bypassing a heat exchange section of the oil cooler flows;
an outlet side passage within which oil passing through the heat exchange section flows; and
a bypass valve disposed at a connection portion between the bypass passage and the outlet side passage,
the bypass valve including a valve element including an inside passage which is formed within the valve element, and within which the oil flows, the bypass passage being connected to the bypass valve from a direction perpendicular to an axial direction of the valve element,
the bypass valve being arranged to be closed to shut off a flow of the oil from the bypass passage to the outlet side passage by the valve element such that the oil passing through the heat exchange section flows within the inside passage, and to be opened to connect the bypass passage and the inside passage such that the oil passing through the bypass passage flows within the inside passage,
wherein
the bypass valve includes a coil spring arranged to constantly urge the valve element in a valve closing direction;
the valve element includes a pressure receiving surface which is formed on an outer circumference of the valve element, and which is arranged to receive a force in a valve opening direction from the oil within the bypass passage; and
the valve element is arranged to be moved in the valve opening direction to connect the inside passage and the bypass passage when the pressure of the oil flowing within the inside passage is decreased, and when the pressure of the oil acting on the pressure receiving surface becomes greater than an urging force of the coil spring.

US Pat. No. 10,138,765

CONTROL VALVE FOR VALVE TIMING ADJUSTING DEVICE OF INTERNAL COMBUSTION ENGINE

HYUNDAI MOTOR COMPANY, S...

1. A hydraulic control valve for a valve timing adjusting device of an internal combustion engine to selectively supply working fluid to or discharge from the valve timing adjusting device having a housing having an inner space, a rotor installed in the inner space of the housing and configured to work in cooperation with a camshaft, the rotor having a plurality of vanes forming an advance chamber in a direction of adjusting an advance phase angle and a retard chamber in a direction of adjusting a retard phase angle, respectively, and a locking pin member elastically installed at a locking chamber formed at the plurality of vanes to adjust a valve timing in a middle position between a most advance position and a most retard position of the rotor to inhibit or prevent a relative rotation of the rotor to the housing, the hydraulic control valve comprising:a valve body connected to the camshaft and having a plurality of ports and a spool space formed therein;
an outer spool elastically installed in the spool space of the valve body and having a plurality of distribution ports formed through an exterior circumference thereof to be selectively communicated with or disconnected to the plurality of ports of the valve body;
an inner spool integrally coupled at an inside of the outer spool and configured to form a supply passage connected to a working fluid pump and a drain passage connected to a drain tank together with the outer spool, respectively;
wherein the rotor comprises:
an advance fluid passage configured to communicate with the advance chamber,
a retard fluid passage configured to communicate with the retard chamber, and
a locking fluid passage configured to communicate with the locking chamber;
an inflow port to which working fluid is supplied;
an advance port configured to communicate with the advance fluid passage;
a retard port configured to communicate with the retard fluid passage;
a locking port configured to communicate with the locking fluid passage; and
a discharge port configured to discharge the working fluid, and
wherein the hydraulic control valve forms a 5-port 5-position solenoid valve configured to select from a self-locking state to a filling state, an advance control state, a holding state, and a retard control state sequentially based on a movement of the spool against an elastic force of a spring arranged between an inner wall of the spool space and at least one of the inner spool or the outer spool.

US Pat. No. 10,138,756

METHOD FOR DAMPING A GAS-TURBINE BLADE, AND VIBRATION DAMPER FOR IMPLEMENTING SAME

Safran Helicopter Engines...

8. A damping method for blades mounted on a low speed wheel disk of a gas turbine, the disk including a housing under a platform of a blade, configured to receive a vibration damper, the method comprising:providing the vibration damper including a flexible portion including a plate clamped against the platform, and a mass portion including a counterweight for directing friction forces against the platform via clamping, the flexible portion and the mass portion being coupled together in a reversible way by surrounding at least partially the mass portion through at least one clamping area of the flexible portion against the platform, the flexible portion being sufficiently flexible to be configured to a required contact level; and
inserting the vibration damper within the housing,
wherein the plate includes an upper wall arranged on an upper face of the counterweight and configured to flexibly contact the platform of the blade, a rim extended from the upper wall and including first and second longitudinal sides which respectively abut first and second longitudinal sides of the counterweight, and first and second arms which are respectively extended from the first and second longitudinal sides, and
wherein each of the first and second arms includes a radially extending portion and a laterally extending portion bent from the radially extending portion, the laterally extending portions of the first and second arms enclosing a lower face of the counterweight.

US Pat. No. 10,138,745

SEALING SYSTEM WITH TWO ROWS OF COMPLEMENTARY SEALING ELEMENTS

SAFRAN AIRCRAFT ENGINES, ...

1. A sealing system in a cavity under a stator sector of a turbomachine flow path, comprising a stator sector and a rotor device, the cavity being located between a root of a vane of the stator sector and the complementary rotor device,the root comprising a first surface provided at least partially with an abradable coating,
the rotor device being provided with at least one first sealing element arranged facing the first surface, the first surface and the first sealing element forming a first sealing pair and delimiting a first leakage section between them,
wherein:
the root comprises a second surface provided at least partially with an abradable coating,
the rotor device being provided with at least one second sealing element arranged facing the second surface, the second surface and the second sealing element forming a second sealing pair and delimiting a first leakage section between them,
the first sealing pair tending towards a minimum leakage section when the second pair tends towards a corresponding maximum leakage section, and the first leakage pair tending towards a maximum leakage section when the second pair tends towards a minimum leakage section during an engine mission,
the first and second sealing pairs being at an axial spacing from each other.

US Pat. No. 10,138,734

TURBINE RING FOR A TURBOMACHINE

SAFRAN HELICOPTER ENGINES...

1. A turbine ring comprising:a cylindrical support; and
one or more sectors forming a circle configured to define a segment of an air passage, each sector being fastened to the support by an attachment device;
wherein the attachment device comprises a hook portion belonging to the support and projecting towards the sector, and a hook portion belonging to the sector and projecting towards the support, the hook portions of the support and of the sector being configured to co-operate in order to fasten the sector to the support;
a damper device provided within the attachment device and stressed radially between a portion of the sector and a portion of the support so as to damp relative movements between the sector and the support; and
wherein the damper device comes into contact in alternation, in the circumferential direction, with an inner surface of the support and with an outer surface of the hook portion of the sector.

US Pat. No. 10,138,721

METHOD OF AND A DEVICE AND AN ELECTRONIC CONTROLLER FOR MITIGATING STICK-SLIP OSCILLATIONS IN BOREHOLE EQUIPMENT

ENGIE ELECTROPROJECT B.V....

1. A method of mitigating stick-slip oscillations in borehole equipment for drilling a borehole in an earth formation, said borehole equipment comprising a drill string having a bottom hole assembly and a top end coupled to a rotational drive system, and a speed controller for controlling rotational drive speed of said drive system, the method comprising the steps of:operating said speed controller such that said drive speed is above a lower drive speed limit, that has a non-zero value, while drilling a borehole by said borehole equipment, wherein said lower drive speed limit is determined from:
modelling said borehole equipment by an equivalent computational model for computer simulation,
loading elements of said model with physical quantities representing an initial state of said borehole equipment causing a transition of said bottom hole assembly from stick mode to slip mode,
simulating in said loaded model a transition representative of said transition of said bottom hole assembly from stick mode to slip mode,
registering time domain relaxation dynamics in said model from said simulating step, thereby obtaining a time response of a rotational driven speed of said bottom hole assembly comprising a transitional phase and a steady state phase, and
determining from said time response of the time domain relaxation dynamics said lower drive speed limit as a drive speeder at, or below, which said rotational driven speed of said bottom hole assembly reaches a value of zero during one or more portions of the transitional phase,
wherein the modelling comprises modelling of each of the drill string, the bottom hole assembly, the rotational drive system, and the speed controller by a respective equivalent computational model for computer simulation, and
wherein the loading of the elements includes loading of each of the respective equivalent computational model with a respective physical quantity representing the initial state of the borehole equipment.

US Pat. No. 10,138,698

EXTERNAL LOCKING MECHANISM FOR SEAL ENERGIZING RING

VETCO GRAY, LLC, Houston...

1. A wellhead apparatus comprising:an outer wellhead member having a bore with an axis;
a hanger landed in the bore;
a seal assembly between the hanger and an interior side wall of the outer wellhead member, the seal assembly having an energizing ring that moves axially downward relative to the hanger to a set position that causes the seal assembly to set; and
a lockdown member secured in the bore against axial movement, the lockdown member having a lower end, and the lower end having an annular rib extending from a downward facing surface that bears against an upper end of the energizing ring while the energizing ring is in the set position.

US Pat. No. 10,138,696

RADIAL CONDUIT CUTTING SYSTEM

Otto Torpedo Company, Pl...

1. An igniter comprising:an igniter housing adapted to be positioned in a conduit, said igniter housing comprising a containment sub and a nozzle sub that are releasably secured to each other;
a heater in said igniter housing comprising:
a combustible pellet insertable into said igniter housing, said combustible pellet for creating a flow of heated gas when said combustible pellet is ignited while said igniter is in use;
said igniter is free from a loose powdered form of combustible material when said combustible pellet is in said igniter housing; and
a pellet igniting device; and
said nozzle sub for directing the flow of heated gas.

US Pat. No. 10,138,693

METHOD OF DRILLING A SUBTERRANEAN BOREHOLE

MANAGED PRESSURE OPERATIO...

1. A method of drilling a subterranean wellbore using a drill string comprising the steps of:a. injecting a drilling fluid into the well bore via the drill string and removing the drilling fluid from an annular space around the drill string (the annulus) via an annulus return line in which a main control choke is provided,
b. oscillating the pressure of the fluid in the annulus, the oscillation of the pressure in the annulus being achieved by oscillating the main control choke so that a degree to which the main control choke restricts a fluid flow along the annulus return line is alternately decreased and increased,
c. determining a wellbore storage volume and a wellbore storage coefficient for each fluid pressure oscillation, the wellbore storage volume being a change in a measured flow rate over a time period, and the wellbore storage coefficient being the wellbore storage volume divided by a pressure change over the time period,
d. using the wellbore storage volume and wellbore storage coefficient to determine the proportion by volume of gas and the proportion by volume of liquid in the annulus during that pressure oscillation, and
e. controlling a gain setting of the main control choke in accordance with the proportion by volume of gas in the annulus,
wherein,
the main control choke has a higher gain setting when the proportion by volume of gas in the annulus is higher,
the main control choke has a lower gain setting when the proportion by volume of gas in the annulus is lower,
the higher gain setting allows the main control choke to adjust a flow rate by a predetermined amount in a first time,
the lower gain setting allows the main control choke to adjust the flow rate by the predetermined amount in a second time, and
the first time is shorter than the second time.

US Pat. No. 10,138,684

MULTI CYCLE DOWNHOLE TOOL

NOV DOWNHOLE EURASIA LIMI...

1. An under-reaming tool comprising:a body;
a plurality of extendable cutters coupled to the body, wherein the cutters have an extended position extending from the body and a retracted position retracted into the body, the under-reaming tool configured to be cycled between a first configuration in which the cutters are in the retracted position and a second configuration in which the cutters are movable between the retracted position and the extended position; and
an activation member configured to move the cutters between the retracted position and the extended position, the activation member comprising an effective sealing area;
wherein the under-reaming tool is configured to selectively vary the effective sealing area to selectively vary a hydraulic bias of the activation member; and
wherein the under-reaming tool is configured to prevent the transition of the cutters to the extended position in response to an external fluid pressure outside the body in the first configuration, in the second configuration, or in both the first configuration and the second configuration.

US Pat. No. 10,138,679

ELEVATED WORKING PLATFORM AND RELATED METHODS

Wing Enterprises, Incorpo...

1. An elevated platform apparatus comprising:a first assembly having a pair of rails coupled with a plurality of rungs;
a second assembly having a pair of rails, the second assembly being hingedly coupled with the first assembly;
a platform pivotally coupled to the first assembly, the platform including a deck and a toe-kick structure, the toe-kick structure including at least one wall configured to be displaced between a first position, wherein the at least one wall extends outward from a working surface of the deck at a substantially perpendicular angle, and a second position, wherein the at least one wall is positioned substantially flat against the working surface of the deck, wherein the first assembly and the second assembly are configured to pivot relative to each other between a deployed state and a collapsed state, wherein when the first and second assemblies are in the deployed state, the platform extends from the first assembly and engages a portion of the second assembly;
a cage associated with the platform, the cage including:
at least one gate, the at least one gate being configures to swing in a first direction upon a user stepping on to the platform from the first rail assembly, and swing back to a closed position after the user is standing on the working surface of the platform, the at least one gate also being limited from being displaced in a second direction, opposite the first direction, beyond the closed position,
a pair of extension members pivotally coupled with the pair of rails of the first assembly,
an upper bar being pivotally coupled with the pair of extension members and also being pivotally coupled with the pair of rails of the first assembly,
a lower bar pivotally coupled with the pair of rails of the second assembly;
at least one first link member having a first end pivotally coupled with the second assembly and a second end pivotally coupled with the platform;
at least one second link member having a first end pivotally coupled with the lower bar and a second end pivotally coupled with the platform, wherein the second end of the at least one first link member and the second end of the at least one second link member share a common point of pivotal connection with the platform; and
a latch member associated with the at least one wall and configures to engage the at least one second link member to maintain the at least one side wall in the first position.

US Pat. No. 10,138,677

TORSION ASSEMBLY FOR A CURTAIN

MACAUTO INDUSTRIAL CO., L...

1. A torsion assembly comprising:a connection member comprising
a shaft having an end;
a connection segment formed on the end of the shaft and having
a connection hole radially defined through the connection segment and having a connection surface formed in a side of the connection hole that is adjacent to the shaft; and
a holding groove defined in the connection surface of the connection hole;
a holding protrusion formed in the connection hole and having an end extending toward the connection surface of the connection hole; and
a torsion spring comprising
a spring body mounted around the shaft of the connection member and having an end and an axis;
a connection leg formed on and extending from the end of the spring body, connected with the connection segment of the connection member, and having
a rod segment formed on and protruding from the end of the spring body, being parallel with the axis of the spring body, and having an end opposite the spring body;
a bent segment connected with the end of the rod segment, being perpendicular to the rod segment, extending toward the axis of the spring body, held in the holding groove in the connection member to be kept from escaping out of the holding groove by the holding protrusion, and having an end opposite the rod segment; and
a hook segment connected with the end of the bent segment, being perpendicular to the bent segment, and extending toward the spring body, wherein the rod segment and the hook segment are located respectively at two diametrical ends of the connection segment of the connection member.

US Pat. No. 10,138,676

ROLLER SHADE WITH A COUNTERBALANCING DEVICE

Hunter Douglas Industries...

1. A roller shade comprising:a flexible sheet member;
a roller shaft rotatable in each of two opposite directions of rotation, the flexible sheet member having a first end coupled to the roller shaft and a second end freely depending from the roller shaft, so as to define a raised position of the roller shade in which the flexible sheet member is wound about the roller shaft and a lowered position in which the flexible sheet member is unwound from the roller shaft;
a counterbalancing device for balancing a portion of the flexible sheet member that is unwound from the roller shaft, the counterbalancing device including:
a stationary central rod;
a helically wound tension spring for storing a variable torque complementary to a variable weight of the portion of the flexible sheet member that is depending from the roller shaft, one end of the helically wound tension spring being coupled to a spring holder and an opposite end of the helically wound tension spring being coupled to a spring winder;
a screw threaded shaft provided in operative association with the spring winder; and
a rod adjuster that is selectively rotatable to rotate the stationary central rod relative to the screw threaded shaft so as to increase or decrease the tension of the helically wound tension spring by relative rotation of the spring holder; and
a bottom bar coupled to the second end of the flexible sheet member;
wherein:
the variable torque stored in the helically wound tension spring prevents rotation of the roller shaft due to the variable weight of the portion of the flexible sheet member depending from the roller shaft in any position between the fully wound and the fully unwound position and increases as the second end of the flexible sheet member is lowered; and
the rod adjuster is engageable to adjust the tension in the helically wound tension spring when the roller shaft is mounted in position on mounting brackets.

US Pat. No. 10,138,672

MOUNTING SYSTEM FOR A CAMERA

Serge B. Hoyda, Great Ne...

1. An apparatus configured to view people through a door comprising:at least one mount;
at least one electronic device comprising a display configured to be coupled to said at least one mount; and
at least one camera coupled to the electronic device;
wherein said at least one mount comprises at least one coupling element for coupling said at least one electronic device to said at least one mount and wherein said at least one mount is configured to allow the electronic device to be mounted on a surface;
at least one telescoping scope coupled to said at least one camera and to said at least one electronic device, said at least one telescoping scope configured to be adjustable in length and to extend through the door from an inside surface of the door to an outside surface of the door wherein said camera and said at least one electronic device are positioned on an inside surface of the door; and
at least one power line extending through the door and into a wall and coupled at one end to at least one of said at least one electronic device and said at least one camera at one end and to a wall feed at an opposite end.

US Pat. No. 10,138,669

ACTUATING SYSTEM FOR A DOOR OF AN ELECTRICAL DOMESTIC APPLIANCE

NUOVA STAR S.P.A., Zola ...

1. An automatic system for actuating a door of an electrical domestic appliance comprising a frame and a door, which is movable compared to the frame, the system comprising:a first hinge body which can be fixed to the frame;
a second hinge body, which can be fixed to the door;
a hinge pivotally connecting the first hinge body to the second hinge body to allow the first hinge body to pivotally move between a first closed position, wherein the door is abutted against the frame and the second hinge body is positioned at a first angle to the first hinge body, and a second open position, wherein the door is spaced from the frame and the second hinge body is positioned at a second angle to the first hinge body, the second angle being different than the first angle, thus allowing access to an operating compartment of the electrical domestic appliance;
an actuating system for pivotally actuating the second hinge body with respect to the first hinge body, comprising:
an electric actuators; and
a motion transmission member connected between the electric actuator and the second hinge body for transmitting motion from the electric actuator to the second hinge body,
wherein the motion transmission member is flexible and includes a metal cable.

US Pat. No. 10,138,660

MULTIPLE POINT DOOR LOCKING SYSTEM

Hanchett Entry Systems, I...

1. A door lock system, comprising:a) a frame having a first side and a second side opposite said first side;
b) a deadbolt and a door latch connected to said frame configured to move between retracted and extended positions;
c) a first rotary control connected to said frame, said first rotary control having a first axis of rotation and configured to control deadbolt movement between extended and retracted positions via a primary cam mechanism rotatable about a second axis of rotation off-spaced from said first axis of rotation and acted upon by said first rotary control, wherein said primary cam mechanism includes a split two piece cam having first and second pieces each separately rotatable about said second axis of rotation, wherein said first piece includes a first actuating arm, and wherein said second piece includes a second actuating arm;
d) a second rotary control having a third axis of rotation off-spaced from said first and second axes of rotation and configured to control latch movement between extended and retracted positions; and
e) a link configured to positively move said deadbolt to said retracted position in response to operation of said second rotary control when said latch is moved toward said retracted position by said second rotary control, as effected via a rotary input to said second rotary control from one of said first or second sides of said frame,
wherein, upon rotary input to said second rotary control, said link is configured to move along a linear path normal to said movement of said deadbolt and said door latch and to contact said primary cam mechanism upon said link movement to affect movement of said deadbolt between said retracted and said extended positions.

US Pat. No. 10,138,627

METHOD OF ASSEMBLY OF COMPOSITE CORE SANDWICH EDGE JOINT

THE BOEING COMPANY, Chic...

1. A composite wall assembly edge joint, comprising:a first composite buildup pad secured to a first composite face sheet with the first composite buildup pad having a first tapered section with a first inclined surface which extends in a first direction and having a second section which extends from the first tapered section with a second surface which extends in a second direction, different from the first direction, toward a first end of the first composite face sheet; and
a composite flute core member, comprising:
a tapered first portion secured to the first tapered section of the first composite buildup pad;
a second portion which extends in a third direction away from the tapered first portion and is secured to the first composite face sheet; and
a third portion which extends in the second direction, away from the tapered first portion, toward the first end of the first composite face sheet secured to the second section of the first composite buildup pad.

US Pat. No. 10,138,626

METHOD AND APPARATUS FOR REPAIRING A TILT WALL CONSTRUCTION

PATENTS OF TOMBALL, LLC, ...

1. A method of repairing a tilt wall construction, the tilt wall construction having at least one wall supported by a pier in the earth, the method comprising:affixing a fixture at a bottom of the wall;
installing a piling into the earth directly below said fixture, said piling having a head at an upper end thereof, the step of installing a piling comprising:
driving a plurality of pile segments one upon another into the earth for a desired distance directly below said fixture; and
affixing said head onto a top of said plurality of pile segments;
forming a support member having a length corresponding to a distance between said fixture and said head of said piling; and
affixing said support member to said fixture and to said head such that said piling supports the wall.

US Pat. No. 10,138,048

SOFT-SIDED INSULATED CONTAINER WITH LID FITTING

CALIFORNIA INNOVATIONS IN...

1. A soft-sided insulated container having:a soft-sided insulated body and a top;
said body defining an insulated chamber therewithin;
said top defining a first closure member of said container and being hingedly movable relative to said body between an open position and a closed position;
said top including a first rigid member, said first rigid member defining a first work surface upon which to rest objects;
said container having a second rigid member, said second rigid member being mounted to said body adjacent to said top;
said second rigid member being movable between a deployed position and a retracted position; and
in said deployed position, said second rigid member defining a second work surface upon which to rest objects.

US Pat. No. 10,138,047

SPIGOT AND SPIGOT GUARD FOR AN INSULATING CONTAINER

YETI Coolers, LLC, Austi...

1. An insulating container, comprising:a base including:
a sidewall structure having a plurality of sides;
a bottom portion connected to a first end of each side of the plurality of sides of the sidewall structure; and
an opening formed at a second end of each side of the plurality of sides of the sidewall structure, opposite the first end of each side of the plurality of sides of the sidewall structure, the opening being configured to allow access to an interior void of the insulating container formed by the sidewall structure and the bottom portion;
a spigot extending through a first side of the sidewall structure, the spigot configured to dispense fluid stored in the interior void, the spigot further including:
a spigot body including a spout for dispensing the fluid; and
an insulating container mount configured to secure the insulating container, wherein the mount is secured to a platform, and wherein the insulating container mount is configured to allow access to the interior void when the insulating container is secured to the mount, the container mount further including:
a plurality of anchor points and a mount plate, wherein the anchor points and the mount plate are configured to receive the insulating container.

US Pat. No. 10,138,040

TOOL HOLDER PREVENTING BEING DISMANTLED FROM A TOOL

Hong Ann Tool Industries ...

1. A tool holder comprising:a first holding member having first and second ends and first and second sides extending between the first and second ends thereof, with the first holding member including at least one restraining protrusion adjacent to the first side of the first holding member and having a fixed end fixed to the first holding member and a free end opposite the fixed end, with the at least one restraining protrusion including a first edge thereof defining a first restraining side with a first hooking structure having a first height and a second edge thereof opposite the first edge defining a second restraining side, with the first hooking structure including at least one first tooth; and
a second holding member incorporable with the first holding member to form a holding space, with the second holding member having first and second ends and first and second sides extending between the first and second ends of the second holding member, with the second holding member including at least one catching slot adapted to engage with the at least one restraining protrusion, with the at least one catching slot including a first edge thereof including a first limiting structure having a second height and a second edge thereof opposite the first edge of the at least one catching slot and including a second limiting structure, with the second limiting structure extending from the second edge of the at least one catching slot having a free end spaced from the second edge of the at least one catching slot, with the second limiting structure being cuttable from the second edge of the at least one catching slot, with the first limiting structure including a ridge; wherein the first and second holding members in a first arrangement include:
the holding space formed therebetween with the first and second holding members prevented from being separated from one another,
the first sides of the first and second holding members connected together and the second sides of the first and second holding members connected together,
the first and second holding members include the ridge engaging with the at least one first tooth,
the at least one restraining protrusion engaging in the at least one catching slot,
the first hooking structure engaging with the first limiting structure,
the second restraining side and the second limiting structure having a gap tolerance therebetween not greater than the first and second heights,
the free end spaced from the second edge of the at least one catching slot with the gap tolerance, and
the first hooking structure of the at least one restraining protrusion disengaging from the first limiting structure when the second limiting structure is cut from the at least one catching slot.

US Pat. No. 10,138,037

CLOSURE FOR A PACKAGE

Closure Systems Internati...

1. A closure comprising:a polymeric top wall portion;
a polymeric liner;
a polymeric disc, the polymeric disc being located between the polymeric top wall portion and the polymeric liner; and
a polymeric annular skirt portion depending from the polymeric top wall portion, the annular skirt portion including: (1) an internal thread formation for mating engagement with an external thread formation of a container, (2) an internal bead to assist in positioning the polymeric liner and the polymeric disc, and (3) an internal prying projection to assist in removing the closure from the container, the internal prying projection being located adjacent to or contacting the internal bead, the internal prying projection extending farther inwardly toward a center of the closure than the internal bead,
wherein at least a portion of each of the internal bead and internal prying projection is located between the polymeric liner and the internal thread formation.

US Pat. No. 10,137,686

INK JET HEAD AND INK JET APPARATUS HAVING THE SAME

TOSHIBA TEC KABUSHIKI KAI...

1. An ink jet head, comprising:a pressure chamber connected to a nozzle;
an actuator configured to cause liquid in the pressure chamber to be ejected from the nozzle by deforming a wall of the pressure chamber, wherein the nozzle is disposed through the actuator; and
a drive circuit configured to apply voltage to the actuator to drive the actuator, wherein
when a droplet of the liquid is ejected from the nozzle, the voltage applied to the actuator is changed from a first value to a second value that causes the pressure chamber to expand, and then changed from a third value that is equal to the second value, or between the first value and the second value, to the first value after a time period ?, which is a primary natural oscillation period of the actuator when the pressure chamber and the nozzle are filled with the liquid.

US Pat. No. 10,137,658

VACUUM INSULATOR AND REFRIGERATOR HAVING SAME

SAMSUNG ELECTRONICS CO., ...

1. A refrigerator comprising:an outer case;
an inner case accommodated in the outer case;
a refrigerating cycle; and
a vacuum insulator disposed between the outer case and the inner case,
wherein the vacuum insulator comprises:
a sack-shaped enveloping member having a gas barrier property; and
a core member enclosed in the enveloping member, the core member including one or more sheets, each including a plurality of inorganic fibers,
an inside of the enveloping member is decompressed, and
at least one sheet of the one or more sheets comprises a plurality of bundled inorganic fibers formed by bundling some inorganic fibers from among the plurality of inorganic fibers, and at least a part of the bundled inorganic fibers are in contact with each other,
wherein the at least one sheet comprises in the range of 10 to 200 bundled inorganic fibers per 1 cm3.

US Pat. No. 10,137,636

THREE-DIMENSIONAL MODELLING AND/OR MANUFACTURING APPARATUS, AND RELATED PROCESSES

VOXEL 3D LLC, Salt Lake ...

1. A method of building a three dimensional object, comprising:building a first layer of the three dimensional object including addressing multiple two dimensional locations of a curative matrix thereby simultaneously activating a curable material forming the first layer of the three dimensional object.

US Pat. No. 10,137,635

SYSTEM AND METHOD FOR PRINTING PATH PLANNING FOR MANUFACTURING OF FUNCTIONALLY GRADED MATERIALS WITH THE AID OF A DIGITAL COMPUTER

Palo Alto Research Center...

10. A method for printing path planning for functionally graded material with the aid of a digital computer, comprising steps of:retrieving one or more characteristics of a 3D printer, the printer comprising two or more reservoirs, each of the reservoirs shaped to store a printing material, the printer further comprising a mixing chamber for mixing the materials supplied from two or more of the reservoirs upon receiving material extrusion commands, and at least one printer head for extruding the mixed materials as a material mix;
obtaining a representation of a layer of a functionally graded material object, the layer having a polygonal shape and comprising a plurality of points associated with a composition of the material mix, to be printed by the printer, wherein printing by the printer comprises extruding at every point the material mix of the composition associated with that point;
for each of the points, computing rates of change in the material composition between the composition associated with that point and the compositions associated with one or more other of the points located in one or more directions from that point, and to compare the determined rates of change to a threshold;
determining for each of the points whether the printer head can move while printing the layer to one or more of the other points along one or more of the directions based on the characteristics, the rates of the change between that point and the other points, and the material composition at that point and the other point, wherein the printer head is determined to be able to move between that point and one of the other points if the rate of change associated with that point and the other point is below the threshold;
defining boundaries of a plurality of polygons comprised within the polygonal shape that can be printed by the printer head moving in one or more of the directions based on the determinations;
generating a path for the head to follow to print all of the polygons based on the boundaries; and
generating the material extrusion commands based on the generated path,
wherein the steps are performed by a suitably-programmed computer and wherein the printer prints all of the polygons based on the generated path and the material extrusion commands.

US Pat. No. 10,137,630

CONTROL METHOD OF EMBOSSING APPARATUS

Graphtec Corporation, Ka...

1. A control method of an embossing apparatus, comprising:moving a cutting tool including a blade to a position facing a predetermined first target position of a medium to be processed, by controlling an operation of a first driving device configured to move, in a first direction, a support member on which the medium to be processed is adhered, and an operation of a second driving device configured to move the cutting tool and an embossing tool which recesses the medium to be processed by pressing, in a second direction parallel to a major surface of the support member and different from the first direction;
controlling an operation of a first pressing device configured to move the cutting tool in a third direction perpendicular to the major surface of the support member, thereby sticking the blade into the first target position of the medium to be processed, and stopping the blade in a state in which a blade edge is positioned between upper and lower surfaces of the medium to be processed;
forming a cut line on a boundary between a non-processing portion where embossing is not performed and an embossing portion by moving the support member in the first direction by the first driving device, and moving the cutting tool in the second direction by the second driving device, in the state in which the blade is stuck in the medium to be processed;
moving the cutting tool to a position where the blade is pulled out from the medium to be processed, by controlling the operation of the first pressing device;
moving the embossing tool to a position facing a second target position along the cut line of the medium to be processed, by controlling the operations of the first driving device and the second driving device;
controlling an operation of a second pressing device configured to move the embossing tool in the third direction, thereby pressing the embossing tool against the second target position, and forming a recess in the medium to be processed; and
forming on the medium to be processed, after forming the cut line, an embossed portion formed of a continuous recess extending along the cut line and breaking the medium to be processed on the cut line, by moving the support member in the first direction by the first driving device, and moving the embossing tool in the second direction by the second driving device, in the state in which the embossing tool is pressing the medium to be processed.

US Pat. No. 10,137,624

METHOD TO DIRECT COMPOUND EXTRUDED STRUCTURE FOR THE PRODUCTION OF IRRADIATION CROSSLINKED POLYPROPYLENE FOAM

TORAY PLASTICS (AMERICA),...

1. A method of manufacturing an extruded structure, comprising:introducing resin into a feeder of an extruder;
injecting a liquid crosslinking agent into the extruder using an injector at a location downstream of the feeder within 4 to 8 screw diameters of an axial length of the extruder;
introducing a chemical blowing agent into the extruder at a location downstream of the location where the liquid crosslinking agent is injected into the extruder; and
extruding a structure from the extruder.

US Pat. No. 10,137,619

HEADER FOR MODULE OF HOLLOW FIBER MEMBRANES AND METHOD OF POTTING HOLLOW FIBERS

ZENON TECHNOLOGY PARTNERS...

1. A method of producing a membrane module comprising the steps of:a) forming a bundle of hollow fiber membranes, the membranes held together by a layer of adhesive material spaced from the ends of the membranes to provide a potting region between the layer of adhesive material and the ends of the membranes;
b) placing the bundle of membranes in a mold wherein the mold seals against the adhesive material to form a substantially closed cavity surrounding the potting region;
c) injecting a liquid potting material into the cavity such that the potting material flows around the membranes; and,
d) solidifying the potting material in a seal with the membranes.

US Pat. No. 10,137,594

SINGLE STEP CREOSOTE/BORATE WOOD TREATMENT

Stella-Jones Inc., Saint...

1. A wood treatment composition comprising:(1) at least about 3% w/w of a reaction product of C2-C6 monoalkanolamine and boric acid; and 2) at least about 90% w/w creosote; wherein the reaction product comprises a C2-C6 monoalkanolamine ester of boric acid; and the composition is greater than 98% free of water and is a homogeneous mixture.

US Pat. No. 10,137,591

TOOLING AND A METHOD FOR WEAKENING AN OUTLINE IN A THIN PLASTICS CARD

IDEMIA FRANCE, Colombes ...

1. A method, comprising:weakening a first outline in a thin plastic card, wherein weakening the first outline comprises:
a first go punching step by means of a first go punch presenting a solid shape substantially identical to the first outline and suitable for punching the thin plastic card along a go direction against a first die presenting a first hollow shape substantially identical to the first outline and in alignment with the first go punch;
receiving a first material pushed by the first go punch into the first hollow shape of the first die; and
a first return punching step by means of a first return punch presenting a solid shape substantially identical to the first outline in alignment with the first go punch and suitable for punching the first material along a return direction opposite to the go direction; and
weakening a second outline in the thin plastic card, wherein weakening the second outline comprises:
a second go punching step by means of a second go punch presenting a solid shape substantially identical to the second outline and suitable for punching the thin plastic card in a second go direction against a second die presenting a second hollow shape substantially identical to the second outline and in alignment with the second go punch;
receiving a second material pushed by the second punch into the second hollow shape of the second die; and
a second return punching step by means of a second return punch presenting a solid shape substantially identical to the second outline in alignment with the second go punch and suitable for punching the second material along a second return direction opposite to the second go direction.

US Pat. No. 10,137,587

AXE AND AXE HEAD

1. An axe comprising:an axe head and a handle to which one end portion of the axe head is mounted,
wherein the axe head is formed of a flat blade stock of generally uniform thickness,
wherein the axe head having a sharpened cutting edge,
wherein the axe head having a frame section comprising a first side face and a second side face, and a first side edge and a second side edge between the first side face and the second side face,
wherein the axe head defining a first axe head side on the first side face of the frame section and a second axe head side on the second side face of the frame section,
wherein the centre of gravity of the axe is located on a centre-of-gravity plane, which is parallel with a blade plane on which the sharpened cutting edge of the axe head is located and which is located at a distance from the blade plane and which is parallel with a normal working motion plane of the axe,
wherein the sharpened cutting edge of the axe head and the centre of gravity of the axe are arranged to cooperate when the sharpened cutting edge of the axe head hits a wood and the sharpened cutting edge of the axe head penetrates into the wood such that at least some of the impact force of the axe head is converted into a rotational motion of the axe head and a motion of the axe head in a curvilinear trajectory, and
wherein:
the axe head having a first handle attaching structure, which extends from the first side edge of the frame section of the axe head and which is located on the first axe head side of the axe head,
the axe head having a second handle attaching structure, which extends from the second side edge of the frame section of the axe head and which is located on the first axe head side of the axe head,
the frame section of the axe head, the first handle attaching structure of the axe head, the second handle attaching structure of the axe head are parts of a one-piece structure formed by plastically deforming and cutting said flat blade stock of generally uniform thickness,
the first handle attaching structure being provided with a first opening that is penetrated by the handle, and
the second handle attaching structure being provided with a second opening that is penetrated by the handle.

US Pat. No. 10,137,571

OPERATION CONTROL SYSTEM AND OPERATION CONTROL METHOD

HONDA MOTOR CO., LTD., T...

1. An operation control system comprising:a movable member having a first mechanical element;
an actuator which moves the movable member at a variable velocity;
a second mechanical element which is configured separately from the movable member and which is fixed at a position so as to be capable of making contact with the first mechanical element;
an operation state recognizing unit which recognizes an operation state including a position and a velocity of the first mechanical element; and
an actuator control unit that outputs, to the actuator, a stop instruction for stopping an operation of the actuator in a case where the position and the velocity of the first mechanical element recognized by the operation state recognizing unit depart from a predetermined allowable range in a two-dimensional coordinate system, the two-dimensional coordinate system expressed by a position and a velocity,
wherein in a case where a predetermined conditional expression is established which uses a position and a velocity of the first mechanical element, a collision time, a component indicating an allowable force which is allowable for the first mechanical element or the second mechanical element, a component indicating a resistance force applied to the movable member by the actuator, and a component indicating an inertia force applied to the first mechanical element, the actuator control unit determines that the position and the velocity of the first mechanical element are within the allowable range.

US Pat. No. 10,137,569

MULTI-ARTICULATED MANIPULATOR

NIPPON THOMPSON CO., LTD....

1. A multi-articulated manipulator comprising:a plurality of hollow outer shells,
grasping members comprising a pair of claw members, and
a plurality of power-transmission shafts to actuate the plurality of outer shells and the grasping members,
wherein the plurality of outer shells comprise a foremost outer shell having a first end and a second end, the second end connected to the grasping members and a basement outer shell articulatedly connected to the first end of the foremost outer shell,
wherein the plurality of power-transmission shafts are inserted in the basement outer shell and the foremost outer shell, and comprising a pair of claw power-transmission shafts operated independently from each other to actuate the pair of claw members of the grasping members, and
wherein the claw members are configured to be operated independently from each other by respective independent operation of each of the claw power-transmission shafts around a first fulcrum pin defining a first fulcrum and fastened to the second end of the foremost outer shell in a first diametrical direction with respect to the second end of the foremost outer shell, and
further comprising a first spring having a first end and a second end, the first end connected to a first one of the claw members and a second end connected to a second one of the claw members, the first spring extending around the first fulcrum to energize a tensile force to urge the claw members towards a closed position.

US Pat. No. 10,137,566

AUTOMATED GUIDED VEHICLE (AGV) WITH BATCH PICKING ROBOTIC ARM

Bastian Solutions, LLC, ...

1. A system, comprising:an automated guided vehicle (AGV);
a loading table on the AGV, wherein the loading table includes at least one conveyor;
a plurality of storage containers arranged on the conveyor;
a gantry moveably coupled to the AGV, wherein the gantry spans over the storage containers on the conveyor;
a robotic arm mounted to the gantry at a position above the storage containers on the conveyor, wherein the robotic arm is configured to pick from and/or put into the storage containers on the conveyor one or more items at a time when the conveyor is stationary;
a gantry drive system configured to move the gantry relative to the loading table to facilitate servicing of the storage containers on the conveyor by the robotic arm when the conveyor is stationary; and
wherein the conveyor is configured to move to discharge the storage containers from the AGV.

US Pat. No. 10,137,560

JEWELRY MANDREL PLIERS AND METHOD OF USING SAME

Wubbers, LLC, South Lake...

1. A pair of mandrel pliers for forming a material during the manufacture of jewelry, the pair of mandrel pliers comprising:a first member forming a first handle, wherein the first member has a first proximate end and a first distal end;
a second member forming a second handle, wherein the second member has a second proximate end and a second distal end, and wherein the first member and the second member are pivotably joined at a central connection point;
a first mandrel jaw pivotably fastened to the first member at the first distal end, and wherein the first mandrel jaw is slidably engaged to a second rail housed between opposing sidewalls of the second member at a position between the second proximate end and the second distal end;
a second mandrel jaw pivotably fastened to the second member at the second distal end, and wherein the second mandrel jaw is slidably engaged to a first rail housed between opposing sidewalls of the first member at a position between the first proximate end and the first distal end; and
wherein the first mandrel jaw and the second mandrel jaw are capable of securely gripping the material at a location between the first mandrel jaw and the second mandrel jaw upon an application of a squeezing force to the first handle and the second handle, and wherein the first mandrel jaw and the second mandrel jaw are parallel to each other upon the application of the squeezing force
the pair of mandrel pliers further comprising an adjustment screw that controls a width of a gap between the first mandrel jaw and the second mandrel jaw when the mandrel pliers are in a closed configuration.

US Pat. No. 10,137,549

MILLING CUTTER WITH LUBRICATION CONDUITS

DECATUR DIAMOND, LLC, De...

1. A lubricant distribution device configured to be coupled to a rotating cutting tool having a plurality of circumferentially spaced cutting surfaces, the lubricant distribution device comprising:a main body having a manifold conduit extending along a central rotational axis of the main body; and
a plurality of lubricant distributing conduits configured to convey a lubricant therethrough, the plurality of lubricant distributing conduits formed in the main body and extending radially outwardly from the manifold conduit, each of the lubricant distributing conduits including an inlet fluidly coupling each of the lubricant distributing conduits to the manifold conduit and an outlet disposed adjacent a corresponding one of the circumferentially spaced cutting surfaces of the cutting tool, wherein each of the lubricant distributing conduits includes a transitional portion wherein a direction of flow of the lubricant changes from flowing parallel to the central rotational axis of the main body to flowing radially outwardly away from the central rotational axis of the main body, wherein each of the transitional portions is arcuate in shape and curves around an axis arranged perpendicular to the central rotational axis of the main body.

US Pat. No. 10,137,542

WIND TURBINE ROTOR BLADE COMPONENTS AND MACHINE FOR MAKING SAME

SENVION GMBH, Hamburg (D...

1. A method for making, storing, dispensing, tapering, cutting and assembling one or more preform layers of material to form a structural element for a wind turbine blade comprising the steps of:(a) providing a preform layer of material of certain length dimensions and certain width dimensions, the preform layer of material including multiple elongate strength rods arranged longitudinally and parallel relative to one another and parallel to the length dimension in a single layer, each strength rod being disposed adjacent to and spaced from at least one adjacent strength rod;
each strength rod including multiple, collimated structural fibers fixed in a solidified matrix resin;
the preform layer including at least one carrier layer to which the multiple strength rods are joined by an adhesive;
wherein the carrier layer spaces adjacent strength rods a fixed distance apart to facilitate the flow of liquid bonding resin between adjacent strength rods of the preform layer to its joined carrier layer, the carrier layer further being of a permeable material suitable to facilitate the flow of liquid bonding resin through the carrier layer;
(b) receiving coiled lengths of the preform layer of material provided from step (a);
(c) dispensing lengths of the preform layer of material;
(d) partially grinding through portions across the width of the preform layer of material at predetermined lengths along the length of the preform layer of material, the partial grinding forming a V-shape across the width of the preform layer of material;
(e) cutting the grinded portions of material at the vertex of the V-shape to produce cut preform layers of predetermined lengths;
(f) stacking each length of cut preform layer with one or more other preform layers;
(g) causing liquid bonding resin to flow between adjacent strength rods and through the carrier layer to which the strength rods are joined and to adjacent stacked preform layers; and,
(h) solidifying the liquid bonding resin to fix the stacked preform layers to form a structural element for a wind turbine blade.

US Pat. No. 10,137,531

METHODS AND SYSTEMS FOR SEPARATING AN EDGE PORTION OF A WORKPIECE USING A LASER

TRUMPF Laser- und Systemt...

1. A method for cutting off an edge portion of a workpiece, the method comprising:applying a laser to the workpiece to form at least a plurality of individual severing cuts in the edge portion such that the edge portion is cut off from the workpiece, the plurality of individual severing cuts being arranged together along the edge portion,
wherein applying the laser to the workpiece to form the plurality of individual severing cuts comprises, for each individual severing cut of the plurality of individual severing cuts:
translating a laser cutting head and/or the workpiece relative to one another to form a first portion of the individual severing cut extending along a first direction;
altering a translation direction of the laser cutting head and/or the workpiece to form a second portion of the individual severing cut extending along a second different direction toward the edge of the workpiece;
detecting, at an end of the individual severing cut, an edge of the workpiece, wherein the translation of the laser cutting head or the workpiece continues at least until the edge is detected; and
after detecting the edge of the workpiece, translating the laser cutting head and/or workpiece relative to one another to a start position for a next individual severing cut, wherein the start position of the next individual severing cut occurs at a position on the workpiece where the individual severing cut changes from extending along the first direction to extending along the second direction.

US Pat. No. 10,137,528

BLANK ETCHING FIXTURE

AUTODIE LLC, Grand Rapid...

1. A blank etching apparatus that positions an etching screen relative to a blank comprising:a worktable including a table top and a base that supports said table top;
said table top having a top surface that supports the blank in a support plane that defines an x-axis and a y-axis;
said table top having a pair of lateral sides and a pair of longitudinal sides that extend between said pair of lateral sides;
a first jig that is movable with respect to said table top along said x-axis and that is fixed with respect to said table top along said y-axis, said first jig including a first pair of lateral segments that are disposed adjacent said pair of lateral sides of said table top and a first pair of longitudinal segments that extend between said first pair of lateral segments; and
a screen frame received between said first pair of longitudinal segments and said first pair of lateral segments of said first jig that is moveable along said y-axis relative to said first jig and said table top and that receives and carries the etching screen where said first jig and said screen frame cooperate to accurately and repeatably position the etching screen relative to the blank.

US Pat. No. 10,137,521

METHOD AND SYSTEM FOR SUBMERGED ARC WELDING

ESAB AB, Gotenborg (SE)

1. A method for submerged arc welding, comprising:guiding a first hot wire towards a work piece and transferring current to said first hot wire for arc generation to create a weld puddle;
guiding a cold wire at a variable feed speed towards said weld puddle, wherein the cold wire is configured such that no arc is generated between the cold wire and the work piece;
continuously measuring, during a welding phase, at least a first active welding parameter related to said first hot wire, wherein the at least a first active welding parameter is continuously adapted to existing welding conditions;
continuously determining different target values for the variable feed speed of the cold wire based on different values of the at least a first active welding parameter, wherein a different value of the at least a first active welding parameter results in determination of a different target value for the variable feed speed of the cold wire; and
adjusting the variable feed speed of the cold wire to the different target values.

US Pat. No. 10,137,520

INITIATION OF WELDING ARC BY RESTRICTING OUTPUT

Thermal Dynamics Corporat...

1. A method for generating a weld during a start of a welding process, the method comprising:initially generating a welding output power by a control circuit, wherein the control circuit is configured to simultaneously limit a current and increase an inductance from an initial start of the welding process;
continuously determining a welding energy output or a first period of time that the welding output power is provided;
determining a second period of time for providing a current pulse, the second period of time is based on a run-in percentage of a wire feed speed and an output voltage, and a magnitude of the current pulse varies during the second period of time; and
providing a normal welding parameter after either: the welding energy output exceeds an energy output threshold, or the first period of time exceeds a time threshold.

US Pat. No. 10,137,509

ROTARY CUTTING TOOL

Kyocera SGS Precision Too...

1. A rotary cutting tool comprising:a body having a cutting portion and a shank portion, the cutting portion having a length;
a plurality of helical flutes formed in the cutting portion of the body,
wherein adjacent helical flutes form an index angle therebetween in each radial plane along the axial length of the flutes,
a plurality of peripheral cutting edges formed along an intersection of a circumferential surface of the cutting portion of the body and a portion of an inner surface of a respective one of the helical flutes facing in a direction of rotation of the body, each peripheral cutting edge having a radial rake angle,
the index angle between at least two adjacent helical flutes being different from the index angle between at least one other pair of adjacent helical flutes in at least one of the radial planes.

US Pat. No. 10,137,508

MINIATURIZED DEBURRING AND/OR CHAMFERING TOOL WITH INTERNAL COOLING

Heule Werkzeug AG, Balga...

1. Miniaturized deburring and/or chamfering tool with a cylindrical guide sleeve in which a blade holder base body is arranged in an exchangeable manner, which has at least one receiving slot for receiving and guiding a blade arranged there, which is leaf-shaped and designed so that it can bend along its longitudinal axis, and which, at its free front end, has a cutting head with a deburring or chamfering blade arranged there, the leaf-shaped blade configured to permit movement of the cutting head generally radially relative to a longitudinal axis of the tool out of the slot to an extended deburring/chamfering position and into the slot to a retracted non-deburring/chamfering position, wherein an internal cooling of the blade and removal of shavings from the blade are achieved by coolant flowing around the blade in the receiving slot on at least two facing sides.

US Pat. No. 10,137,503

METHOD AND APPARATUS FOR PRODUCTION OF UNIFORMLY SIZED NANOPARTICLES

ATTOSTAT, INC., Salt Lak...

1. A stable nanoparticle composition comprising:a polar liquid selected from the group consisting of deionized water, alcohol, and a solution thereof; and
metal nanoparticles that are nonionic and have a mean diameter less than 35 nm and a ? potential greater than ±20 mV so as to remain dispersed in the polar liquid without a surfactant, wherein at least 99% of the metal nanoparticles have diameters within ±3 nm of the mean diameter,
wherein the metal nanoparticles are selected from the group consisting of silver, gold, copper, platinum, and an alloy of silver and gold,
wherein the nanoparticle composition is substantially free of metal ions from the metal nanoparticles.

US Pat. No. 10,137,489

ROTARY STAMPER

FORMTEK, INC., Westfield...

1. A method for rotary stamping of a workpiece, said method comprising the steps of:providing a drive assembly to a support frame;
operatively connecting an upper die plate assembly to said drive assembly for horizontal and vertical movement; and
operatively connecting a lower die plate to said drive assembly for movement in a linear horizontal direction only;
defining opposed side clearance cutouts in said lower die plate wherein said lower die plate includes opposed cam plates positioned within said opposed side clearance cutouts, said cam plates having a pair of opposing legs;
slidably connecting said upper die plate assembly to said lower die plate via opposed alignment rods for maintaining a substantially constant alignment therewith as said upper die plate assembly moves vertically towards and away from said lower die plate, said alignment rods extending through said legs; and
passing said workpiece between said upper die plate assembly and said lower die plate during operation of said drive assembly;
wherein said upper die plate assembly has at least a pair of holes permitting said alignment rods to slidably pass through said holes during said vertical movement of said upper die plate assembly;
wherein said horizontal and vertical movements of said upper die plate are directly driven by said drive assembly.

US Pat. No. 10,137,479

TEMPORAL MULTIPLEXED EXCITATION FOR MINIATURIZED, PLANAR FLUORESCENCE ACTIVATED CELL SORTING

Verily Life Sciences LLC,...

1. A system comprising:at least two excitation lasers;
an objective that directs light from the at least two excitation lasers to a common point in an interrogation region of a fluidic channel via a first optical path, wherein the fluidic channel directs a flow of a plurality of fluorescently labeled particles through the interrogation region;
a beamsplitter that provides a side scatter beam comprising light from one of the at least two excitation lasers, wherein the side scatter beam is directed to the fluidic channel via a second optical path, and wherein the second optical path is different than the first optical path;
a side scatter detector for detecting side scattered light from particles in the fluidic channel passing through the side scatter beam;
at least one modulator that temporally multiplexes light from the at least two excitation lasers such that pulses of light from different lasers intersect the common point in the interrogation region of the fluidic channel at different times;
at least one fluorescence detector; and
at least one optical element optically coupled to the objective and the at least one fluorescence detector to direct light emitted from the plurality of fluorescently labeled particles and transmitted through the objective to the at least one fluorescence detector.

US Pat. No. 10,137,275

OXYGEN CONCENTRATOR FOR HIGH PRESSURE OXYGEN DELIVERY WITH OXYGEN CIRCULATION LOOP AND IMPROVED PORTABILITY

BreatheTechnologies, Inc....

1. A portable apparatus for concentrating and delivering high pressure oxygen to a ventilator, the apparatus comprising:an enclosure defining an air inlet, an oxygen outlet and a flow pathway extending between the air inlet and the oxygen outlet;
a high pressure compressor disposed within the enclosure and integrated into the flow pathway, the high pressure compressor having a compressor inlet fluidly coupled to the air inlet, and a compressor outlet;
an adsorbent sieve bed disposed within the enclosure and integrated into the flow pathway, the sieve bed having a sieve bed inlet fluidly coupled to the compressor outlet of the high pressure compressor, and a sieve bed outlet, with the sieve bed being operative to remove nitrogen from air flowing therethrough;
a high pressure accumulator disposed within the enclosure and integrated into the flow pathway, the high pressure accumulator having an accumulator inlet fluidly coupled to the sieve bed outlet of the adsorbent sieve bed, and an accumulator outlet fluidly coupled to the oxygen outlet;
a first valve disposed within the enclosure and integrated into the flow pathway so as to be interposed between and fluidly coupled to both the sieve bed outlet of the sieve bed and the accumulator inlet of the accumulator, the first valve being operative to prevent flow from the high pressure accumulator to the sieve bed;
a third valve disposed within the enclosure and integrated into the flow pathway so as to be interposed between and fluidly coupled to both the air inlet and the compressor inlet of the high pressure compressor; and
an oxygen circulation loop having a first end fluidly coupled to the flow pathway between the third valve and the compressor inlet of the high pressure compressor, and a second end fluidly coupled to the flow pathway between the sieve bed outlet of the sieve bed and the first valve;
the oxygen circulation loop being operative to permit oxygen enriched gas to be circulated through the sieve bed, with the third valve being operative to prevent flow of the oxygen enriched gas to ambient via the air inlet;
the high pressure compressor, the sieve bed and the high pressure accumulator being sized and configured to allow the apparatus to operate at a pressure level in the range of from about 40-80 psi.

US Pat. No. 10,137,243

INFUSION DEVICES WITH DISTRIBUTED MOTOR CONTROL AND RELATED OPERATING METHODS

Medtronic MiniMed, Inc., ...

1. An infusion device comprising:a motor operable to deliver fluid to a body of a user;
a driver module coupled to the motor;
a first switching arrangement coupled between the driver module and an energy source;
a second switching arrangement coupled between the driver module and the motor;
a first control module coupled to the first switching arrangement; and
a second control module coupled to the first control module, the driver module, and the second switching arrangement, the first control module operating the first switching arrangement to provide a path for input power from the energy source to the driver module in accordance with a handshaking sequence of communications between the first control module and the second control module and providing a dosage command to the second control module, the second control module operating the second switching arrangement to provide a path for output power from the driver module to the motor in accordance with the handshaking sequence of communications and operating the driver module to deliver the output power comprising a portion of the input power to the motor based at least in part on the dosage command.

US Pat. No. 10,137,239

SYSTEMS AND METHODS FOR MONITORING TIME BASED PHOTO ACTIVE AGENT DELIVERY OR PHOTO ACTIVE MARKER PRESENCE

Avedro, Inc., Waltham, M...

1. A system for monitoring treatment of corneal tissue, comprising:an excitation source that directs light to the corneal tissue treated with a cross-linking agent, the light causing the cross-linking agent to fluoresce;
an image capture system that captures one or more images of the corneal tissue in response to the excitation source directing the light to the corneal tissue, the one or more images showing the fluorescing cross-linking agent; and
a controller that is configured to receive the one or more images of the corneal tissue and to provide information relating to cross-linking activity with the cross-linking agent in the corneal tissue based on one or more wavelengths emitted by the fluorescing cross-linking agent,
wherein the excitation source directs the light to the corneal tissue along an axis; the image capture system includes a camera and a lens; the camera captures the one or more images of the corneal tissue via the lens; the camera and the lens are offset from the axis defined by the light; the camera defines an image plane; the lens defines a lens plane; the lens plane is separate from the image plane; the one or more images of the corneal tissue are associated with a focal plane defined by the camera and the lens; and the camera and the lens are oriented such that the image plane, the lens plane, and the focal plane all intersect each other at a common intersection.

US Pat. No. 10,137,238

METHOD OF STORING BOTH NEW AND USED PEN NEEDLES

Becton, Dickinson and Com...

1. A method for storing both new and used pen needles of an injection apparatus in a single storage assembly, comprising the steps of:removing a cover to access a new pen needle secured within an opening of said assembly;
attaching said new pen needle to a drug delivery pen, wherein said new pen needle is releasably secured within said opening and prevented from rotating; and
pulling the new pen needle from one end of said opening to remove the new pen needle, wherein such removal motion serves to pull a slidable internal holder within the assembly forward, thereby creating a space at an opposite end of said opening for a used pen needle to be inserted and stored.

US Pat. No. 10,137,230

SKIN INTERFACE DEVICE HAVING A SKIN ATTACHMENT DEVICE AND METHOD TO IMPLANT SAME

NuPulseCV, Inc., Raleigh...

1. A skin attachment device, comprising:a) an annular ring having a central aperture extending therethrough and defining an inside surface;
b) a fixturing assembly,
wherein the fixturing assembly is adapted to couple to the annular ring via one or more threaded screws which extend through apertures disposed in the fixture assembly and are received by one or more threaded apertures disposed in the annular ring,
wherein the annular ring further comprises a groove extending annularly around an outside surface of the ring thereby defining upper and lower lips,
wherein the upper lip comprises one or more vertical apertures extending therethrough adapted to accept a suture, and
wherein the groove is texturized to promote tissue ingrowth upon implantation of the skin attachment device.

US Pat. No. 10,137,209

GADOLINIUM CHELATE COMPOUNDS FOR USE IN MAGNETIC RESONANCE IMAGING

BAYER PHARMA AKTIENGESELL...

1. A compound of general formula (I), comprising 4, 5, 6, 7 or 8 gadolinium [4,7,10-tris(carboxylatomethyl)-1,4,7,10-tetraazacyclododecan-1-yl] groups,
in which:
represents a group selected from:

in which * on the A group indicates a point of attachment of the A group with R1;
R1 represents, independently from each other, a hydrogen atom or a substituent group selected from:

R3,
in which * on the substituent group indicates a point of attachment of the substituent group with A group,
with the proviso that zero or only one of the R1 groups present in the compound represent a hydrogen atom;
n represents an integer of 3 or 4;
R2 represents, independently from each other, a hydrogen atom or a methyl group;
R3 represents a group selected from:

in which * on the R3 group indicates a point of attachment of the R3 group with a nitrogen on the A group or the substituent group;
R4 represents, independently from each other, a hydrogen atom or a methyl group; and
R5 represents, independently from each other, a hydrogen atom or a methyl group;
or a stereoisomer, a tautomer, an N-oxide, a hydrate, a solvate, or a salt thereof, or a mixture of same.

US Pat. No. 10,137,186

COMPOSITIONS AND METHODS FOR LIVE, ATTENUATED ALPHAVIRUS FORMULATIONS

Takeda Vaccines, Inc., C...

1. A live, attenuated alphavirus virus composition comprising:one or more live, attenuated alphaviruses, wherein the live, attenuated alphaviruses are selected from the group consisting of chikungunya (CHIK) virus, o'nyong'nyong virus, Eastern equine encephalitis, Western equine encephalitis, and Venezuelan equine encephalitis;
10.0 mM to 20.0 mM HEPES buffer;
one or more carbohydrate agents having a concentration from 1.0% to 15% (w/v) selected from the group consisting of: trehalose, sucrose, mannitol, sorbitol, and galactose; and
0.1% to 1.0% (w/v) gelatin but does not contain human serum albumin (HSA), wherein the composition stabilizes the live attenuated alphaviruses.

US Pat. No. 10,137,161

MEDICAL CANNABIS LOZENGES AND COMPOSITIONS THEREOF

1. A lozenge consisting essentially of extracted cannabis sativa oil, extracted cannabis indica oil, and xylitol, wherein the extracted cannabis sativa oil and the extracted cannabis indica oil comprise cannabidiol and tetrahydrocannabinol.

US Pat. No. 10,137,147

REDUCING THE PROLIFERATION OF LUNG CARCINOMA CELLS (A549) BY ADMINISTRATION OF A POLY-OXYGENATED METAL HYDROXIDE

BAYLOR UNIVERSITY, Waco,...

1. A method of treating a mammal, comprising administering a therapeutically effective amount of a poly-oxygenated aluminum hydroxide composition to the mammal in need thereof to reduce a proliferation of lung carcinoma A549 cells, wherein the poly-oxygenated aluminum hydroxide composition comprises a clathrate containing fee oxygen gas (O2) molecules; and wherein the therapeutically effective amount of the poly-oxygenated aluminum hydroxide composition ranges from 10 mg/L to 1000 mg/L.

US Pat. No. 10,137,137

ATP SYNTHASE INHIBITORS AND STEROID ALKALOIDS AND USES THEREOF AS ANTIMICROBIAL AGENTS AND AS POTENTIATORS FOR AMINOGLYCOSIDES AGAINST PATHOGENIC BACTERIA

Socpra Sciences et Genie ...

1. A method for preventing or treating a bacterial infection in a subject or for the disinfection, sterilization and/or antisepsis of an object contaminated by the bacteria by administering to the subject or applying on the object a compound of formula (I):
wherein:
R1 is H; and R2 is —NR5R6; or
R1 is —NR5R6; and R2 is H;
wherein R5 and R6 are identical or different and are selected from the group consisting of H; substituted or unsubstituted alkyl; substituted or unsubstituted aryl; substituted or unsubstituted aralkyl; substituted or unsubstituted cycloalkyl, and substituted or unsubstituted —(CH2)nNR7R8,
wherein n is 2-10; and
R7 and R8 are identical or different and are selected from the group consisting of H, substituted or unsubstituted alkyl, substituted or unsubstituted aryl; substituted or unsubstituted cycloalkyl, and substituted or unsubstituted aralkyl;
wherein the substituted alkyl(s), substituted aryl(s), substituted aralkyl(s), substituted cycloalkyl(s), and substituted —(CH2)nNR7R8 comprise(s) one or more identical or different substitutions selected from alkyl, aryl, cycloalkyl and aralkyl; and
R10 is H, substituted or unsubstituted alkyl, or substituted or unsubstituted —(CH2)pNR13R14,
wherein p is 2-10; and
R13 and R14 are identical or different and are selected from the group consisting of H, substituted or unsubstituted alkyl, substituted or unsubstituted aryl, substituted or unsubstituted cycloalkyl, and substituted or unsubstituted aralkyl;
wherein substituted alkyl, substituted aryl, substituted aralkyl, substituted cycloalkyl, and substituted —(CH2)pNR13R14 comprises one or more identical or different substitutions selected from alkyl, aryl, cycloalkyl and aralkyl,
with the proviso that when R1 is NH2 and R2 is H; or R1 is H and R2 is NH2, R10 is not H,
or a stereoisomer or mixture of stereoisomers or a salt thereof.

US Pat. No. 10,137,131

PHARMACEUTICAL COMPOSITIONS COMPRISING MELOXICAM

AXSOME THERAPEUTICS, INC....

1. A dosage form comprising a combination of: 1) a complex of meloxicam with a sulfobutyl ether ?-cyclodextrin (SBE?CD), 2) a bicarbonate, and 3) a triptan; wherein the dosage form contains 400 mg to 600 mg of the bicarbonate, about 5 mg to about 50 mg of meloxicam, and about 50 mg to about 200 mg of SBE?CD; and wherein the dosage form is a solid oral dosage form having a shorter Tmax of meloxicam in a human being than a reference dosage form that: 1) contains the same amount of meloxicam, 2) does not contain an SBE?CD, and 3) does not contain a bicarbonate.

US Pat. No. 10,137,130

METHODS OF TREATMENT OF MALIGNANCIES

Celgene Corporation, Sum...

1. A method of treating acute myeloid leukemia in a subject comprising administering to the subject a mutant isocitrate dehydrogenase 2 (IDH2) inhibitor 2-methyl-1-[(4-[6-(trifluoromethyl)pyridin-2-yl]-6-{[2-(trifluoromethyl)pyridin-4-yl]amino}-1,3,5-triazin-2-yl)amino]propan-2-ol having the following formula:or a pharmaceutically acceptable salt, solvate, or tautomer thereof, wherein the acute myeloid leukemia is characterized by the presence of a mutant allele of IDH2 and the absence of a mutant allele of FLT3.

US Pat. No. 10,137,125

BENZENESULFONAMIDE DERIVATIVES OF QUINOXALINE, PHARMACEUTICAL COMPOSITIONS THEREOF, AND THEIR USE IN METHODS FOR TREATING CANCER

NEUPHARMA, INC., Foster ...

1. A compound of Formula I:or a pharmaceutically acceptable salt thereof, whereinR1, R2, R3, R4, R5, R6, R8, and R10 are independently hydrogen, cyano, halo, hydroxy, azido, nitro, carboxy, sulfinyl, sulfanyl, sulfonyl, optionally substituted alkoxy, optionally substituted aryloxy, optionally substituted heteroaryloxy, optionally substituted heterocycloalkyloxy, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted aryloxy, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted heterocycloalkyl, optionally substituted amino, optionally substituted acyl, optionally substituted alkoxycarbonyl, optionally substituted aminocarbonyl, optionally substituted aminosulfonyl, optionally substituted carbamimidoyl, or optionally substituted alkynyl;
R7 is halo;
R9 is optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted aryl, or optionally substituted heteroaryl; and
R11 is hydrogen, optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted heterocycloalkyl, optionally substituted aryl, or optionally substituted heteroaryl.

US Pat. No. 10,137,118

CRYSTALLINE POLYMORPHS OF THE FREE BASE OF 2-HYDROXY-6-((2-(1-ISOPROPYL-1H-PYRAZOL-5-YL)PYRIDIN-3-YL)METHOXY)BENZALDEHYDE

Global Blood Therapeutics...

1. A crystalline ansolvate of Compound 1:
characterized by at least three X-ray powder diffraction peaks (Cu K? radiation) selected from 11.65°, 11.85°, 12.08°, 16.70°, 19.65° and 23.48 °2? (each ±0.2 °2?).

US Pat. No. 10,137,117

CRYSTALLINE N-[5-(AMINOSULFONYL)-4-METHYL-1,3-THIAZOL-2-YL]-N-METHYL-2[4-(2-PYRIDINYL)PHENYL]ACETAMIDE MONO MESYLATE MONOHYDRATE HAVING A SPECIFIC PARTICLE SIZE DISTRIBUTION RANGE AND A SPECIFIC SURFACE AREA RANGE FOR USE IN PHARMACEUTICAL FORMULATIONS

AiCuris Anti-Infective Cu...

1. A composition of crystalline N-[5-(aminosulfonyl)-4-methyl-1,3-thiazol-2-yl]-N-methyl-2-[4-(2-pyridinyl)-phenyl]acetamide mono methanesulfonic acid monohydrate particles of the following formula
having a purity of >99%,
wherein said particles in the composition have a particle size range from 2 ?m to 500 ?m, a particle size distribution which is defined by d(0.1) from 2 to 100 ?m, d(0.5) from 30 to 210 ?m and d(0.9) from 70 to 400 ?m and a specific surface area of less than 1.0 m2/g.

US Pat. No. 10,137,110

1-CYCLOHEXYL-2-PHENYLAMINOBENZIMIDAZOLES AS MIDH1 INHIBITORS FOR THE TREATMENT OF TUMORS

Bayer Pharma Aktiengesell...

1. A compound of formula (I)
wherein:
R1 is a halogen atom or a group selected from the group consisting of:
C1-C6-alkyl, C1-C6-alkoxy, C1-C6-haloalkyl, C1-C6-haloalkoxy, cyano, (C1-C6-alkyl)-S—, and (C1-C6-haloalkyl)-S—;
R2 is a hydrogen atom;
R3 is a hydrogen atom;
R4 is a hydrogen atom;
R5 is a phenyl or heteroaryl group,
wherein said phenyl or heteroaryl group is optionally substituted with one or more substituents independently selected from the group consisting of:
halo-, cyano, C1-C6-alkyl, C3-C6-cycloalkyl, C1-C6-haloalkyl, C1-C6-haloalkoxy, nitro, R13O—, R13S—, R13OC(?O)—(C1-C6-alkyl)-, R13OC(?O)—(C2-C6-alkenyl)-, R13OC(?O)—(C1-C6-alkoxy)-, R14(R15)NC(?O)—(C1-C6-alkyl)-, R14(R15)NC(?O)—(C2-C6-alkenyl)-, R14(R15)NC(?O)—(C1-C6-alkoxy)-, (C1-C6-alkyl)-S—, (C1-C6-alkyl)-S(?O)—, (C1-C6-alkyl)-S(?O)2—, (C1-C6-haloalkyl)-S—, —C(?O)OR13, —C(?O)N(R14)R15, —C(?O)N(R14)S(?O)2R16, —N(R14)R15, —N(R14)C(?O)R16, —N(R14)C(?O)R17, —N(R14)S(?O)2R16, —S(?O)2OR13, and —S(?O)2N(R14)R15;
R6 is a hydrogen atom, a halogen atom, or a group selected from the group consisting of C1-C6-alkyl and C1-C6-alkoxy;
R7 is a hydrogen atom;
R8 is C1-C3-alkyl;
R9, R10, and R11
are independently selected from the group consisting of hydrogen and C1-C3-alkyl;
R12 is a hydrogen atom;
R13 is a hydrogen atom or a group selected from the group consisting of:
C1-C6-alkyl, C3-C6-cycloalkyl, HO—(C2-C6-alkyl)-, and (C1-C3-alkoxy)-(C2-C6-alkyl)-;
R14 and R15
are independently selected from the group consisting of:
hydrogen, C1-C6-alkyl, C3-C6-cycloalkyl, HO—(C2-C6-alkyl)-, (C1-C3-alkoxy)-(C2-C6-alkyl)-, H2N—(C2-C6-alkyl)-, (C1-C3-alkyl)N(H)(C2-C6-alkyl)-, (C1-C3-alkyl)2N(C2-C6-alkyl)-, R13OC(?O)—(C1-C6-alkyl)-, 4- to 6-membered heterocycloalkyl, phenyl, heteroaryl, phenyl-(C1-C6-alkyl)-, and
heteroaryl-(C1-C6-alkyl)-,
wherein said phenyl and heteroaryl groups are optionally substituted with one or two substituents independently selected from the group consisting of:
C3-C6-cycloalkyl, C1-C3-alkoxy, C3-C6-cycloalkyloxy, C1-C3-haloalkoxy, halogen, cyano, —C(?O)OR13, and —C(?O)NH2;
or
R14 and R15
are taken together with the nitrogen atom to which they are attached to form a 4-6-membered heterocycloalkyl,
wherein said 4-6-membered heterocycloalkyl is optionally substituted with one substituent selected from the group consisting of:
C1-C3-alkyl C1-C3-haloalkyl C1-C3-alkoxy, C1-C3-haloalkoxy, C3-C6-cycloalkyl, C3-C6-cycloalkyloxy, amino, hydroxy, halogen, and cyano,
or
wherein said 4-6-membered heterocycloalkyl is optionally substituted with one or two halogen atoms;
R16 is a hydrogen atom or a group selected from the group consisting of:
C1-C6-alkyl, C3-C6-cycloalkyl, HO—(C3-C6-cycloalkyl)-, C1-C6-haloalkyl, (C1-C3-alkoxy)-(C1-C6-alkyl)-, phenyl, heteroaryl, and 4- to 6-membered heterocycloalkyl,
wherein said phenyl and heteroaryl groups are optionally substituted with one or two substituents independently selected from the group consisting of:
C1-C3-alkyl, C3-C6-cycloalkyl, C1-C3-alkoxy, C3-C6-cycloalkyloxy, C1-C3-haloalkyl, C1-C3-haloalkoxy, halogen, cyano, —C(?O)OR13, and —C(?O)N(R14)R15; and
R17 is a group selected from the group consisting of —N(R14)R15 and C1-C6-alkoxy,
or a stereoisomer, a tautomer, an N-oxide, a hydrate, a solvate, or a salt thereof, or a mixture of any of the foregoing.

US Pat. No. 10,137,105

COMBINATION TREATMENT PROTOCOL

Bionomics Limited, Theba...

1. A method for treating chronic lymphocytic leukemia (CLL) in a patient comprising the step of administering effective amounts of (i) a compound which induces egress of CLL cells from lymph node or bone marrow or a pharmaceutically acceptable salt, solvate, stereoisomer or prodrug thereof; and (ii) a compound of Formula (I):or a pharmaceutically acceptable salt, solvate or prodrug thereof, in either order or simultaneously.

US Pat. No. 10,137,049

DRIVING MODULE, MOTION ASSISTANCE APPARATUS INCLUDING THE DRIVING MODULE, AND METHOD OF CONTROLLING THE MOTION ASSISTANCE APPARATUS

Samsung Electronics Co., ...

1. A driving module comprising:a driving source adapted to be on one side of a user, and configured to provide power;
a first decelerator including a first input terminal coupled to the driving source, and a first output terminal and a second output terminal configured to receive power from the first input terminal;
a second decelerator including a second input terminal coupled to the first output terminal, and a third output terminal and a fourth output terminal configured to receive power from the second input terminal; and
a third decelerator including a third input terminal coupled to the second output terminal, and a fifth output terminal and a sixth output terminal configured to receive power from the third input terminal,
wherein the first decelerator is coupled to the second decelerator such that the first output terminal transmits power to the second input terminal,
the first decelerator is coupled to the third decelerator such that the second output terminal transmits power to the third input terminal, and
the first decelerator is between the second decelerator and the third decelerator.

US Pat. No. 10,137,033

TORSIONAL MODE NEEDLE FOR PHACOEMULSIFICATION

Moog Inc., Elma, NY (US)...

1. A phacoemulsification needle for attachment to an ultrasonic handpiece operable to drive the needle back-and-forth in opposite longitudinal directions of the needle at a longitudinal drive frequency and a longitudinal drive magnitude, the phacoemulsification needle comprising:a base adapted for removable attachment to the handpiece; and
an elongated shaft extending from the base along a longitudinal axis, the shaft terminating at a distal tip having a cutting edge;
the base and the shaft including an aspiration lumen passing therethrough;
the shaft further including a plurality of external grooves extending in a longitudinal direction of the shaft;
wherein the plurality of grooves have a configuration that converts oscillatory longitudinal drive motion applied at the base of the needle to torsional motion at the tip of the needle, the torsional motion having a fundamental torsional mode frequency and a torsional mode magnitude, wherein the torsional mode magnitude is greater than the longitudinal drive magnitude;
wherein the plurality of grooves are helical grooves extending in the longitudinal direction of the shaft; and
wherein i) the plurality of grooves consists of exactly six grooves each having a helical pitch less than or equal to 22.86 mm, or ii) each of the plurality of grooves has a depth in a range from 0.102 mm through 0.124 mm and an axial length of 7.62 mm or iii) each of the plurality of grooves has a depth in a range from 0.116 mm through 0.142 mm and an axial length of 10.16 mm, or iv) the plurality of grooves consists of exactly five grooves each having a depth in a range from 0.127 mm through 0.152 mm.

US Pat. No. 10,137,015

KNITTED STENT JACKETS

INSPIREMD LTD., Tel Aviv...

1. An assembly for opening a vessel lumen comprising:a radially expandable stent configured to open the vessel lumen, said radially expandable stent comprising a curved wall having a proximal portion, a distal portion, and a lumen connecting said proximal portion and said distal portion;
a knitted stent jacket comprising a tubular wall that substantially surrounds an exterior surface of said radially expandable stent; and
a plurality of buffering element cords having an external surface placed against an external surface of said knitted stent jacket, covering only a minor portion of a surface of the knitted stent jacket, in a manner which spaces the knitted stent jacket from an adjacent element of the assembly to buffer the knitted stent jacket from movement of the adjacent element, wherein each of the plurality of buffering element cords has a thickness greater than the knitted stent jacket and an entire length of each of the plurality of buffering element cords overlays the knitted stent jacket,
wherein said knitted stent jacket comprises at least three interconnected loops at its distal end, at least one first loop, at least one second loop and at least one third loop; andwherein the assembly comprises at least one separate retainer belt having at least one portion woven through said at least one first loop, past said at least one second loop and through said at least one third loop;said at least one second loop configured to create a run in said knitted stent jacket upon expansion of said radially expandable stent, wherein the distal end forms a terminal end of the knitted stent jacket and the at least three interconnected loops are arranged circumferentially at the terminal end.

US Pat. No. 10,137,012

ANTI-THROMBOGENIC MEDICAL DEVICES AND METHODS

COVIDIEN LP, Mansfield, ...

1. A method comprising:forming an expandable tubular body comprising a plurality of braided filaments, wherein the expandable tubular body is configured to be implanted in a blood vessel, the plurality of braided filaments comprising a first filament comprising platinum or platinum alloy and a second filament comprising cobalt-chromium alloy;
applying a first phosphorylcholine material directly on the platinum or platinum alloy of the first filament;
applying a silane material to the second filament comprising the cobalt-chromium alloy, wherein the silane material comprises a silane selected from the group consisting of 3-glycidoxypropyltrimethoxysilane, 2-(3,4-epoxycyclohexyl)ethyltriethoxysilane, 2-(3,4-epoxycyclohexyl)ethyl-trimethoxysilane, (3-glycidoxypropyl)trimethoxysilane, (3-glycidoxypropyl)triethoxysilane, 5,6-epoxyhexyltriethoxysilane, (3-glycidoxypropyl)methyldiethoxysilane, (3-glycidoxypropyl)methyldimethoxysilane, (3-glycidoxypropyl)dimethylethoxysilane, 3-isocyanatopropyltriethoxysilane, (isocyanatomethyl)methyldimethoxysilane, 3-isocyanatopropyltrimethoxysilane, tris(3-trimethoxysilylpropyl)isocyanurate, (3-triethoxysilylpropyl)-t-butylcarbamate, triethoxysilylpropylethylcarbamate, 3-thiocyanatopropyltriethoxysilane, and combinations thereof; and
applying a second phosphorylcholine material on the silane material on the second filament,
wherein the first and second phosphorylcholine materials each define a thickness of less than 100 nanometers.

US Pat. No. 10,137,004

INSERTION TOOLS AND METHODS FOR MINIMALLY INVASIVE SPINAL FUSION CAGE

Vivonics, Inc., Bedford,...

1. An intervertebral support insertion tool system comprising:a tube having a distal open end for insertion in a patient proximate vertebrae and a proximal open end;
a distal intervertebral support;
a shaft received in the tube proximal open end and having an interface for engaging the distal intervertebral support loaded inside the tube; and
a housing supporting the tube and shaft with a first drive mechanism to advance the shaft in the tube and a second drive mechanism to rotate the shaft.

US Pat. No. 10,136,983

MEDICAL DEVICE HAVING REMOVABLE DEPLOYMENT DEVICE AND AFFIXATION ELEMENT

ATRIUM MEDICAL CORPORATIO...

1. A medical device, comprising:a first layer having an opening formed therein;
a second layer positioned with respect to the first layer to form a pocket therebetween;
a support member at least partially located in the pocket and reconfigurable to enable removal of the support member from the pocket via the opening, wherein the support member includes a spiral separation line that enables the support member to unravel as material separates along the separation line when reconfiguring for removal via the opening; and
an affixation element located in the pocket between the support member and the second layer, and secured directly to a pocket-facing surface of the second layer by a component selected from the group consisting of stitching, a weld, an adhesive, and a fastener.

US Pat. No. 10,136,972

HISTORICAL SCAN REFERENCE FOR INTRAORAL SCANS

Align Technology, Inc., ...

1. A method comprising:receiving, by a processing device, a plurality of intraoral images of a dental site during an intraoral scan session;
determining, by the processing device, that a first intraoral image of the plurality of intraoral images does not satisfy a registration criterion with regards to any other intraoral oral image of the plurality of intraoral images;
determining, by the processing device, that a historical template of the dental site is existent, wherein the historical template is a virtual model of the dental site as generated from additional intraoral images taken during a previous intraoral scan session;
registering, by the processing device, the first intraoral image to one or more remaining intraoral images of the plurality of intraoral images in a three-dimensional space according to the historical template, wherein the first intraoral image is associated with a first region of the dental site that does not overlap with a second region of the dental site associated with the one or more remaining intraoral images;
generating a first surface of the first region based on the first intraoral image;
generating a second surface of the second region based on the one or more remaining intraoral images; and
displaying, by the processing device, relative positions and orientations of the first surface and the second surface, wherein the historical template is not displayed.

US Pat. No. 10,136,946

SURGICAL ANTENNA STRUCTURE

CREO MEDICAL LIMITED, Ch...

1. A surgical instrument comprising:a surgical spatula comprising a flat paddle and a coaxial cable extending away from a first end thereof, wherein the flat paddle contains a planar microwave conveying structure connected to the coaxial cable, the planar microwave conveying structure being formed from a sheet of a first dielectric material having first and second conductive layers on opposite surfaces thereof, and being open along a side of the flat paddle which extends away from the first end to permit a microwave radiation field to be emitted from that side;
an endoscope; and
a microwave generator connected to deliver microwave energy to the spatula via the coaxial cable, which is arranged to run through an instrument channel of the endoscope,
wherein the coaxial cable comprises an inner conductor, an outer conductor coaxial with the inner conductor, and a second dielectric material separating the outer and inner conductors,
wherein the inner and outer conductors extend beyond the second dielectric to overlap opposite surfaces of the flat paddle to electrically contact the first conductive layer and second conductive layer respectively, and
wherein the first conductive layer is spaced from the first end of the flat paddle to electrically isolate the outer conductor from the first conductive layer.

US Pat. No. 10,136,944

SYSTEMS AND METHODS FOR TREATING CANCER AND/OR AUGMENTING ORGAN FUNCTION

AUTONOMIX MEDICAL, INC., ...

1. A composition, for use in blocking at least one of one or more nerves and one or more lymphatic ducts, comprising:a neurolytic agent;
a sympathetic nerve selective neurotoxin for ablating a region surrounding a nutrient artery of a bone; and
an inflammatory agent;
wherein the neurolytic agent comprises ethanol;
wherein the inflammatory agent comprises one or more of poly(lactic-co-glycolic acid) (PLGA), polysaccharides, collagen, silica particles, carbon micro or nanoparticles, and microbeads; and
wherein the sympathetic nerve selective neurotoxin comprises at least one of 6-hydroxydopamine, ?-conotoxin, and bungarotoxin.

US Pat. No. 10,136,943

ELECTROSURGICAL SYSTEM

COSMAN INSTRUMENTS, LLC, ...

1. A system for tissue ablation including an electrosurgical generator, a cannula and an electrode, the cannula including an elongated shaft having a proximal end and a distal end, the cannula shaft including an electrically-conductive active tip distal to an electrically-insulated cannula shaft portion, the cannula shaft including a lumen extending from a proximal opening at the proximal end of the shaft to an exit opening within a distal portion including the distal end of the cannula shaft, the cannula including a cannula hub at the proximal end of the shaft of the cannula, the electrode including an electrode shaft having a proximal end and a distal end, the electrode shaft including an electrically-conductive active tip distal to an electrically-insulated electrode shaft portion, the electrode including an electrode hub at the proximal end of the shaft of the electrode, the electrode conducting a first electrical potential from the electrosurgical generator to the electrode active tip, wherein the electrode and the cannula are configured to be assembled by inserting the electrode shaft into the cannula lumen through the proximal opening such that engagement of the electrode hub with the cannula hub conducts a second electrical potential from the electrosurgical generator to the cannula active tip via the electrode, the electrode active tip and the electrically-insulated electrode shaft portion extend out of cannula lumen through the exit opening, the electrode active tip is electrically insulated from the cannula active tip within the assembly of the electrode and the cannula, and the assembly of the electrode and the cannula is configured to conduct electrical current through bodily tissue between the cannula active tip and the electrode active tip.

US Pat. No. 10,136,939

ENERGY DELIVERY DEVICE HAVING A TRANSLATING OUTER SHEATH

Ethicon LLC, Guaynabo, P...

1. A surgical device, comprising:an end effector having a proximal end, a distal end, and an elongate shaft extending between the proximal and distal ends, the distal end being configured to deliver energy;
a cannulated outer sheath having a proximal end, a distal end, and an intermediate length extending between the proximal and distal ends, the end effector being disposed within the outer sheath, and the distal end having a plurality of holes formed in an outer surface thereof, the holes being in fluid communication with the remainder of the cannulated outer sheath to provide at least one of suction and irrigation to a surgical site;
a nozzle coupled to the proximal end of the outer sheath and configured to translate along a longitudinal axis of the cannulated outer sheath;
a carrier coupled to the nozzle;
a handle portion coupled to the proximal end of the end effector, the handle portion having a switch,
wherein the carrier is coupled to the switch such that operation of the switch distally advances the carrier to distally advance the nozzle with respect to the handle portion to selectively cover the distal end of the end effector with the distal end of the outer sheath, and operation of the switch proximally retracts the carrier to proximally retract the nozzle with respect to the handle portion to selectively expose the distal end of the end effector.

US Pat. No. 10,136,933

ORTHOPEDIC CONNECTIONS

Zimmer, Inc., Warsaw, IN...

1. An orthopedic connection connecting a first orthopedic component to a second orthopedic component, the orthopedic connection comprising:a male-type connecting member projecting from the first orthopedic component and having a general longitudinal axis; and
a female-type aperture situated in the second orthopedic component and in forcible receipt of the male-type connecting member so as to create a securing zone in which a portion of the male-type connecting member makes forcible contact with walls of the female-type aperture and maintains said forcible contact to securely connect the first orthopedic component to the second orthopedic component,
wherein the male-type connecting member includes a distal longitudinal segment and a proximal longitudinal segment,
wherein in a single reference plane that includes said general longitudinal axis the distal longitudinal segment extends in a linear fashion and the proximal longitudinal segment extends in a curvilinear fashion, wherein the distal longitudinal segment adjoins the proximal longitudinal segment at a first location along the male-type connecting member,
wherein the portion of the male-type connecting member that makes forcible contact with walls of the female-type aperture and maintains said forcible contact encompasses the first location and extends distally and proximally of the first location along the male-type connecting member so that the portion includes a part of the distal longitudinal segment and a part of the proximal longitudinal segment,
wherein the female-type aperture being in forcible receipt of the male-type connecting member includes a first non-securing zone in which the distal longitudinal segment of the male-type connecting member is present but the walls of the female-type aperture are not contacted by the distal longitudinal segment, the first non-securing zone located distally of the securing zone,
wherein the female-type aperture being in forcible receipt of the male-type connecting member also includes a second non-securing zone in which the proximal longitudinal segment of the male-type connecting member is present but the walls of the female-type aperture are not contacted by the proximal longitudinal segment, the second non-securing zone located proximally of the securing zone.

US Pat. No. 10,136,925

SPINAL CROSS-CONNECTOR

NuVasive, Inc., San Dieg...

1. A spinal cross-connector for connecting first and second spinal rods, comprising:an L-shaped elongate member having a long portion with a first end and a short portion with a second end;
a first connector configured to directly attach with a first pedicle screw, said first connector includes a first collet head configured to receive a first tulip head of the first pedicle screw and accommodate a first spinal rod residing within the first tulip head, a first clamp configured to slidably receive the first end of the L-shaped elongate member, a first locking member tightenable over the first collet head that both locks the first end of the L-shaped elongate member with respect to the first clamp, and locks the first connector to the first tulip head; and
a second connector configured to directly attach with a second pedicle screw, said second connector includes a second collet head configured to receive a second tulip head of the second pedicle screw and a plurality of cutouts to accommodate a second spinal rod residing within the second tulip head, a second clamp configured to rotatably receive the second end of the L-shaped elongate member, a second locking member tightenable over the second collet head that both locks the second end of the L-shaped elongate member with respect to the second clamp, and locks the second connector to the second tulip head.

US Pat. No. 10,136,912

METHOD, APPARATUS, AND SYSTEM FOR GENERATING ULTRASOUND

Samsung Electronics Co., ...

1. A method to generate a therapeutic ultrasound wave from a therapeutic ultrasound irradiation device, the method comprising:acquiring a medical image comprising anatomical information about a subject using a processor;
calculating one or more characteristics of a heterogeneous tissue in the subject affecting propagation of the therapeutic ultrasound wave based on the medical image using the processor;
determining a parameter of the therapeutic ultrasound wave, using the processor, to create a focal point on the subject using the one or more calculated characteristics; and
generating the therapeutic ultrasound wave at the therapeutic ultrasound irradiation device, using a signal from the processor, the signal determined according to the determined parameter,
wherein the determining of the parameter comprises:
setting a particle velocity of the therapeutic ultrasound wave;
calculating, using the processor, a sound pressure at the focal point that the therapeutic ultrasound wave propagates through the heterogeneous tissue, based on the one or more calculated characteristics of the heterogeneous tissue;
determining, using the processor, whether the sound pressure satisfies a predetermined pressure condition; and
resetting, using the processor, the particle velocity of the therapeutic ultrasound wave, in response to the sound pressure not satisfying the predetermined pressure condition.

US Pat. No. 10,136,911

ANTI-CLOGGING DEVICE FOR A VACUUM-ASSISTED, TISSUE REMOVAL SYSTEM

DePuy Synthes Products, I...

1. A surgical, nucleus pulposus removal system having an anti-clogging device for a vacuum-assisted tissue removal, the system comprising:an anti-clogging device including a tubular cutting head, a suction assembly, a collection handle, the collection handle configured for a manual control of the tubular cutting head in an operable communication with the suction assembly, and a tissue-separation chamber to avoid a clogging of a tissue removal system for a discectomy; wherein,
the tissue separation chamber has
an entry port for the entry of an extracted tissue into the chamber, the extracted tissue having a solid component and a liquid component, the solid component including a nucleus pulposus tissue;
a baffle to separate the solid component from the liquid component; and,
an exit port for the exit of the liquid component from the chamber;
the tubular cutting head is configured for removing a target tissue of a subject, the cutting head having
an outer perimeter that circumscribes a flow of suction through the cutting head;
a lumen circumscribed by the outer perimeter, the lumen guiding the flow of suction and having a central axis;
a forward cutting blade on a distal edge of the outer perimeter, the forward cutting blade configured for (i) cutting the nucleus pulposus tissue in a forward stroke of the cutting head and (ii) excising and directing entry of the excised nucleus pulposus tissue into the lumen on the forward stroke, the forward cutting blade having a first plane and a second plane, the first plane having a plurality of cutting surfaces and positioned at an angle, ?FP, to the central axis of the lumen of the tubular cutting head; and, the second plane having a plurality of cutting surfaces and positioned at an angle, ?SP, to the central axis of the lumen of the tubular cutting head; and,
a blade guard positioned distal to the forward cutting blade and configured to guard an annulus fibrosis tissue from the forward cutting blade upon the forward stroke, the blade guard having a transverse, cross-sectional width that is at least substantially smaller than the width of a transverse cross-section of the lumen to facilitate the entry of the excised nucleus pulposus tissue into the lumen on the forward stroke, such that the desired entry of the excised nucleus pulposus tissue into the lumen on the forward stroke is reduced by less than 50% due to the presence of the blade guard, the blade guard also being a backward cutting blade configured with a barb to hook nucleus pulposus tissue for removal of the nucleus pulposus tissue in a backward stroke of the cutting head, the guard having a double-edged blade tip pointing back into the lumen at an angle, ?2, of greater than 90° to trap tissue, cut tissue, or trap and cut tissue in the lumen in the backwards stroke of the cutting head;
wherein, the cutting head is configured for an operable communication between the lumen and a source of a suction; and,
the suction assembly is configured for an operable communication with the cutting head, the suction assembly comprising an at least substantially rigid suction tube with a central axis and creating the flow of suction for removing the excised nucleus pulposus tissue through the lumen and out of the subject.

US Pat. No. 10,136,910

SURGICAL DEVICE WITH ANTI-BINDING FEATURES

Ethicon LLC, Guaynabo, P...

1. A surgical device, comprising:a handle having an elongate shaft extending distally therefrom;
an end effector at a distal end of the elongate shaft and having first and second jaws that are movable between an open configuration and a closed configuration in which the first and second jaws are configured to engage tissue therebetween;
a closure tube extending through the handle and the elongate shaft and configured to move the first and second jaws between the open configuration and the closed configuration;
a knife pusher shaft disposed at least partially around the closure tube and configured to move a cutting element through the first and second jaws for cutting tissue engaged therebetween; and
a rack coupled to the knife pusher shaft by a ball-and-socket joint such that the knife pusher shaft can pivot relative to the rack, wherein movement of the rack is effective to drive the knife pusher shaft and thereby move the cutting element through the first and second jaws.

US Pat. No. 10,136,893

ENDOVASCULAR ANASTOMOTIC CONNECTOR DEVICE, DELIVERY SYSTEM, AND METHODS OF DELIVERY AND USE

CircuLite, Inc., Teaneck...

1. A delivery system comprising:an anastomotic connector including:
a vascular conduit having a proximal end, a distal end, and a lumen extending therebetween, wherein the vascular conduit is configured to reside within a vascular structure; and
a supply conduit having a proximal end, a distal end, and a lumen extending therebetween, wherein the distal end of the supply conduit forms a bifurcation joint with the vascular conduit and the proximal end of the supply conduit is configured to extend from the vascular structure and couple to an auxiliary device; and
a delivery subassembly, the delivery subassembly having an assembled position including:
a multi-lumen hub having a first lumen and second lumen;
a multi-lumen delivery shaft including a first lumen and a second lumen, the multi-lumen delivery shaft extending through the first lumen of the multi-lumen hub then through the lumen of the supply conduit, through the lumen of the distal end of the vascular conduit, and distally from the distal end of the vascular conduit; and
a secondary delivery shaft extending through the second lumen of the multi-lumen hub then into the proximal end of the vascular conduit, through the lumen of the vascular conduit, and distally from the distal end of the vascular conduit, wherein a distal portion of the secondary delivery shaft extending distally from the distal end of the vasculature conduit and is received by a distal portion of the first lumen of the multi-lumen delivery shaft extending distally from the distal end of the vascular conduit.

US Pat. No. 10,136,892

APPARATUS AND METHOD FOR RESECTIONING GASTRO-ESOPHAGEAL TISSUE

REX Medical, L.P., Radno...

1. An apparatus, comprising:a head having a first jaw and a second jaw, at least one of the first jaw and the second jaw being movable with respect to the other of the first jaw and the second jaw from a first configuration in which the first jaw and the second jaw are spaced apart at a first distance and a second configuration in which the first jaw and the second jaw are spaced apart at a second distance, a stapling assembly of the first jaw having slots through which staples are configured to be passed in one or more rows extending from a proximal end of the first jaw to a distal end of the first jaw, and an anvil surface of the second jaw being configured to form a staple;
a first adjustment assembly configured for gross movement of the first jaw or the second jaw;
a second adjustment assembly including a beam configured for fine movement of the first jaw or the second jaw to maintain a fixed distance there between, wherein the beam is operatively coupled to a pusher and includes a central web portion connecting an upper beam portion and a lower beam portion, the central web portion including a cutting blade which is generally more distal than at least one of a trailing edge of the upper beam portion and a trailing edge of the lower beam portion, and the pusher being configured to cause a staple pusher to move for firing as the beam moves distally;
a handle having one or more actuators configured to move at least one of the first jaw and the second jaw from the first configuration to the second configuration, and to actuate the stapling assembly; and
a shaft coupling the handle to the head; wherein
at least one of the upper beam portion and the lower beam portion is a generally flat plate orthogonally attached to an end of the central web portion and is configured to engage the first jaw or the second jaw entirely from within the first jaw or the second jaw for clamping and alignment; and
the pusher and the central web portion are coplanar with a channel defined in a tissue contacting surface of each of the first jaw and the second jaw when the beam moves distally.

US Pat. No. 10,136,885

THREE SUTURE LARGE BORE CLOSURE DEVICE AND METHODS

ST. JUDE MEDICAL PUERTO R...

1. A vascular closure device, comprising:a body portion;
an anchor positioned distal of the body portion and positionable through a vessel puncture and internal to a vessel wall;
at least three sutures having portions thereof positioned distal of the anchor;
three pairs of needles carried by the body portion;
wherein the three pairs of needles are operable to advance through a vessel wall, connect to the portions of the at least three sutures at a position distal to the anchor, and retract to pull the at least three sutures through the vessel wall, at least one of the three pairs of needles not extending through the anchor while the anchor is positioned internal to the vessel wall and while the at least one of the three pairs of needles is connected to the portions of the at least three sutures at a position distal to the anchor.

US Pat. No. 10,136,876

SYSTEM AND METHOD FOR LOCAL ESTIMATION OF NONLINEAR TISSUE ELASTICITY WITH ACOUSTIC RADIATION FORCE

MAYO FOUNDATION FOR MEDIC...

1. A method for forming an image representing a locally determined nonlinear elastic parameter of a subject with an ultrasound system, the method comprising:a) irradiating the subject with a first ultrasound beam generated by a transducer of the ultrasound system to form a target acoustic radiation force in an origin region of the subject,
wherein the target radiation force has a component that is non-linear with respect to an amplitude of said first ultrasound beam;
b) transforming said first ultrasound beam into a second ultrasound beam generated by said transducer and focused at a detection point of the subject, said detection point being spatially separated from the origin region in a direction transverse to the first ultrasound beam;
c) with said ultrasound system, detecting ultrasound energy reflected from at least two detection points of the subject by irradiating said at least two detection points with the second ultrasound beam while temporally multiplexing said first and second ultrasound beams without mechanical repositioning of said transducer to avoid using another transducer in said ultrasound system,
d) with a programmable processor, operably cooperated with the ultrasound system, determining, from the detected ultrasound energy, echo data indicative of a target shear wave induced in said subject locally, at the origin region, by said target acoustic radiation force,
said target shear wave propagating from said origin region towards said at least two detection points;
determining, from said echo data, a target shear wave displacement;
determining, from the echo data, target parameters of the target shear wave,
said target parameters including at least one of speed and attenuation of the target shear wave;
calculating a normalized shear wave displacement induced in said subject locally, at the origin region, by a normalized acoustic radiation force formed by irradiating said origin region with said first ultrasound beam under normalization conditions,
wherein said normalization conditions are defined by having a unit peak intensity of said first ultrasound beam at a boundary of said transducer;
wherein said calculating includes calculating the normalized shear wave displacement ?sim(x,x0) according to
?sim(x,x0)=?D(x?y)ARF(y,x0)dy,
wherein ARF(y,x0) is normalized radiation force evaluated at point y with x0 being a position of a focal point of the transducer, G is an elastodynamic Green's function, and a volume integral is computed over the origin region D;
e) with the ultrasound system, measuring said nonlinear elastic parameter at the origin region of the subject based on a mean ratio of said target shear-wave displacement to said normalized shear wave displacement, said mean ratio SC(x0) expressed according to a product

wherein S is a peak input intensity, |uobs(xk,x0)| is a measured peak of the normalized shear wave displacement at a measurement point xk, C is a nonlinearity parameter, and a variable x0 denotes a position of the origin region D and a point in a tissue at which the nonlinearity parameter C is evaluated, k is an index of summation, and n is an upper bound of summation;
and
based on the measured nonlinear elastic parameter, spatially differentiating a malignant tissue of the subject from a benign tissue of the subject.

US Pat. No. 10,136,874

X-RAY IMAGING APPARATUS

Vieworks Co., Ltd., Anya...

1. An X-ray imaging apparatus comprising:a bias voltage source that provides a bias voltage to pixels that detect X-rays; and
an automatic exposure control (AEC) processing unit that detects a current flowing between the bias voltage source and the pixels and outputs an AEC signal,
wherein the bias voltage source provides the bias voltage to photodiodes included in the pixels through a common electrode, and the AEC processing unit detects a current flowing between the common electrode and the bias voltage source,
wherein the AEC processing unit includes:
a detector that detects the current and converts into a voltage signal; and
an output unit that outputs an AEC signal depending on a voltage output by the detector,
wherein the detector includes a switch that allows bypassing the current, and
wherein the switch is configured to be open when the X-ray imaging apparatus performs an integration process and closed when the X-ray imaging apparatus performs a readout process.

US Pat. No. 10,136,865

RADIOIMAGING USING LOW DOSE ISOTOPE

Spectrum Dynamics Medical...

23. A nuclear medicine imaging system, comprising:a radioactive-emission camera, comprising:
a plurality of independently moveable detecting units;
a plurality of motion transfer systems, equal in number to a number of said detecting units, each of the motion transfer systems being in mechanical communication with one of the detecting unit, for moving each said detecting unit; and
a controller for optimizing said radioactive-emission camera configured to:
model a body structure, based on its geometry;
model anatomical constraints, which limit accessibility to the body structure;
optimize a camera design using said modeled body-structure and said modeled anatomical constraints.

US Pat. No. 10,136,857

ADJUSTABLE WEARABLE SYSTEM HAVING A MODULAR SENSOR PLATFORM

Samsung Electronics Co., ...

1. A wearable system for measuring physiological data from a device worn about a body part of a user comprising:a base module, the base module comprising a display and a base computing unit, and being positioned on a first side of the body part;
a first sensor module configured to measure a gravitational force experienced by the device;
a second sensor module spatially positioned relative to the base module on a second side opposite to the first side of the body part and over a portion of the body part for measuring one or more physiological characteristics calibrated based on the gravitational force measured with the first sensor module; and
the base module being adjustably positioned on the body part relative to the second sensor module so that the second sensor module maintains its positioning over the body part for sufficient contact with the body part regardless of an anthropometric size of the body part.

US Pat. No. 10,136,856

WEARABLE RESPIRATION MEASUREMENTS SYSTEM

Facense Ltd., Kiryat Tiv...

1. A system configured to collect thermal measurements related to respiration, comprising:a frame configured to be worn on a user's head; and
at least one thermal camera that is physically coupled to the frame; wherein the frame is configured to hold the at least one thermal camera less than 15 cm away from the user's face, such that the at least one thermal camera does not occlude any of the user's mouth and upper lip;
wherein the at least one thermal camera is configured to take thermal measurements of: a portion of the right side of the user's upper lip (THROI1), a portion of the left side of the user's upper lip (THROI2), and a portion of the user's mouth (THROI3).

US Pat. No. 10,136,852

DETECTING AN ALLERGIC REACTION FROM NASAL TEMPERATURES

Facense Ltd., Kiryat Tiv...

1. A system configured to detect allergic reaction, comprising:an inward-facing head-mounted thermal camera (CAM) configured to take thermal measurements of a region on the nose (THN) of a user; and
a computer configured to: generate feature values based on THN, and utilize a machine learning-based model to detect an allergic reaction of the user based on the feature values; wherein the machine learning-based model was trained based on previous THN taken during different days.

US Pat. No. 10,136,849

BIOLOGICAL FLUID COLLECTION DEVICE AND BIOLOGICAL FLUID SEPARATION AND TESTING SYSTEM

Becton, Dickinson and Com...

1. A biological fluid separation device, comprising:a rotatable body having a center of rotation and an outer periphery, the rotatable body having a body inlet adapted to receive a multi-component blood sample;
a separation chamber defined within the rotatable body and in fluid communication with the body inlet and having a chamber outlet spaced apart from the body inlet, the separation chamber adapted to receive both the multi-component blood sample; and
a blood component chamber defined within the rotatable body and in fluid communication with the chamber outlet, wherein when the separation chamber contains the multi-component blood sample and a rotational force is applied to the rotatable body, a blood component of the multi-component blood sample passes from the separation chamber into the blood component chamber and a second component of the multi-component blood sample is retained within the separation chamber,
wherein the blood component chamber is disposed adjacent the center of rotation and the separation chamber is disposed adjacent the outer periphery of the rotatable body.

US Pat. No. 10,136,844

DUAL ELECTRODE SYSTEM FOR A CONTINUOUS ANALYTE SENSOR

DexCom, Inc., San Diego,...

1. A continuous glucose sensor configured and arranged for insertion into a host for and detecting glucose in the host, the sensor comprising:a first working electrode comprising a first resistance domain, wherein the first working electrode is configured to generate a first signal having a first noise component related to a noise-causing species;
a second working electrode comprising a second resistance domain, wherein the second working electrode is configured to generate a second signal having a second noise component related to the noise-causing species; and
a third resistance domain disposed continuously over the first resistance domain and the second resistance domain,
wherein each of the first resistance domain and the second resistance domain is independently formed on the first working electrode and the second working electrode, respectively.

US Pat. No. 10,136,841

MULTI-FUNCTIONAL SMART MOBILITY AID DEVICES AND METHODS OF USE

CAN Mobilities, Inc., Sa...

1. A multifunctional smart cane, comprising:a handle adapted to be gripped by a hand of a user;
a body having a base on one end and coupled to the handle on the other;
a light operable by a light sensor;
a display built into the handle wherein the display is visible to the user while gripping the handle;
one or more activity tracking components carried by the smart cane for collecting information about the user's daily activity;
an electronic memory for storing the collected information about the user's daily activity; and
one or more electronic communication components to transmit the user's daily activity from the electronic memory in the smart cane to another electronic device.

US Pat. No. 10,136,840

FITNESS TRAINING SYSTEM FOR MERGING ENERGY EXPENDITURE CALCULATIONS FROM MULTIPLE DEVICES

NIKE, Inc., Beaverton, O...

1. An apparatus for use with a user performing an exercise comprising:at least one processor;
a first sensor configured to monitor a first exercise performed by the user;
a communication circuit configured to communicate at least energy expenditure information between the apparatus and at least a second device, the energy expenditure information including at least a first energy expenditure estimate corresponding to the first exercise monitored by the first sensor and a second energy expenditure estimate corresponding to a second exercise monitored by at least the second device;
at least one tangible memory storing computer-executable instructions that, when executed by the at least one processor, cause the apparatus at least to:
monitor, with the sensor, the first exercise performed by the user;
receive, from an imaging device, an image of the user performing the first exercise wherein the image includes at least one measurement position on a body of the user;
identify, based on the image, a user movement being performed during the first exercise;
automatically communicate the energy expenditure information between the apparatus and at least the second device after determining a completion of at least one of the first exercise and the second exercise;
determine, by the at least one processor, the first energy expenditure estimate of the user corresponding to the monitored first exercise and the identified user movement;
communicate, by the communication circuit, energy expenditure information between the apparatus and at least the second device after expiration of a specified time interval, the energy expenditure information including the first energy expenditure estimate and the second energy expenditure estimate; and
determine, by the at least one processor, a combined energy expenditure estimate of the user based, at least in part, on the first energy expenditure estimate and the second energy expenditure estimate.

US Pat. No. 10,136,819

SHORT-WAVE INFRARED SUPER-CONTINUUM LASERS AND SIMILAR LIGHT SOURCES FOR IMAGING APPLICATIONS

Omni Medsci, Inc., Ann A...

1. An imaging device, comprising:a first part of the imaging device comprising a first at least one of a plurality of laser diodes, the first at least one of the plurality of laser diodes configured to be pulsed;
a second part of the imaging device comprising a second at least one of the plurality of laser diodes;
the plurality of laser diodes configured to generate light having one or more optical wavelengths, wherein at least a portion of the one or more optical wavelengths is a near-infrared wavelength between 700 nanometers and 2500 nanometers;
a first one or more lenses configured to receive at least a portion of the light from the plurality of laser diodes and to direct at least the portion of the light to tissue;
an array of laser diodes configured to generate light formed as a plurality of spots, the light having one or more optical wavelengths, wherein at least a portion of the one or more optical wavelengths is a near-infrared wavelength between 700 nanometers and 2500 nanometers;
a second one or more lenses configured to receive at least a portion of the light from the array of laser diodes and to direct at least the portion of the light from the array of laser diodes to tissue;
a first receiver comprising one or more detectors;
the first receiver configured to receive at least a portion of light reflected from the tissue from the first one of the plurality of laser diodes, wherein the first receiver is configured to be synchronized to the at least one of the plurality of pulsed laser diodes and is configured to perform a time-of-flight measurement;
an infrared camera configured to receive at least a portion of light from the second one of the plurality of laser diodes reflected from the tissue;
the infrared camera configured to:
generate a first signal while the plurality of laser diodes and the array of laser diodes are off; and
generate a second signal while the second part of the imaging device is on and the first part of the imaging device and the array of laser diodes are off, the second signal based at least in part on a portion of the light from the second part of the imaging device reflected from the tissue;
wherein the infrared camera is configured to difference the first signal and the second signal to generate a two-dimensional or three-dimensional image;
the imaging device coupled to one of a smart phone, tablet, or computer, the smart phone, tablet, or computer comprising a wireless receiver, a wireless transmitter, a display, a voice input module, and a speaker, the smart phone, tablet, or computer configured to receive and to process at least a portion of the time-of-flight measurement, the two-dimensional or three-dimensional image, and the received light from the plurality of spots reflected from the tissue.

US Pat. No. 10,136,818

HIGH RESOLUTION INTRAOPERATIVE MRI IMAGES

Tel Hashomer Medical Rese...

1. A method of providing an intraoperative magnetic resonance image of a target site of a patient body at which a medical procedure is performed, the method comprising:acquiring a high resolution preoperative magnetic resonance image (MRI), MRIo, of a first region of the patient comprising the target site, the MRIo image comprising a plurality of slices MRIo,n having voxels;
acquiring a preoperative, iMRIo image of a second region of the patient comprising the target site, using an iMRI scanner having a field of view (FOV), the iMRIo image comprising a plurality of slices iMRIo,m having voxels;
registering the MRIo image to the iMRIo image to provide a rigid body transform (iRT0) that transforms image MRIo to image iMRIo;
acquiring an iMRI1 image of the target site during performance of the medical procedure;
registering image iMRIo to image iMRI1 to determine a non-rigid body transform (NRT1); and
applying iRT0 and NRT1 to image MRIo to provide a high resolution (hiQ-iMRI1) image.

US Pat. No. 10,136,815

PATIENT MONITORING DEVICE WITH REMOTE ALERT

PHYSIO-CONTROL, INC., Re...

1. A patient monitoring system, comprising:a main patient monitor configured to:
receive and collect one or more patient physiological parameters of a patient, and
provide an alarm in response, at least in part, to an alarm trigger, the alarm trigger including a determination that at least one of the collected patient physiological parameters has reached a predetermined value; and
one or more of remote patient monitors, each of the one or more of remote patient monitors having an alarm reset configured to:
terminate the alarm,
be carried by a caregiver,
receive a signal from the main patient monitor in response to the alarm, and
transmit, by the remote patient monitor carried by the caregiver, feedback on the alarm trigger by the caregiver to other caregivers via the main patient monitor, the feedback comprising one or more of a notification that the patient is being attended, a request by the caregiver for additional help, or a message about resolution of the alarm trigger.

US Pat. No. 10,136,789

ALL-IN-ONE SQUEEZABLE SCRUBBING TOOL

The Clorox Company, Oakl...

1. A cleaning device comprising:(a) a squeezable container housing comprising a bottom wall and a fluid reservoir and an outlet for dispensing, wherein the fluid reservoir is configured such that a lateral depth of the fluid reservoir is at a maximum between upper and lower ends of the reservoir, and the lateral depth of the fluid reservoir gradually decreases from the maximum to the upper end of the fluid reservoir, and the lateral depth of the fluid reservoir gradually decreases from the maximum to the lower end of the fluid reservoir;
(b) a volume of a cleaning composition disposed within the fluid reservoir, wherein the cleaning composition comprises a hypochlorite;
(c) a dispensing valve disposed at or near the outlet, and in fluid communication with the reservoir, the dispensing valve being configured to dispense a cleaning composition from the reservoir through the dispensing valve when the cleaning composition is present in the reservoir and a user squeezes the container housing which subsequently opens the dispensing valve in response to a pressure increase in the reservoir;
(d) a sled having a generally planar configuration and located downstream of the dispensing valve; and
(e) a substrate attached to the sled, the substrate being disposed over or about a dispensing orifice of the dispensing valve so that upon squeezing the squeezable container housing, the cleaning composition, when present in the reservoir, is dispensed from the reservoir, through the dispensing orifice.

US Pat. No. 10,136,786

CHARGING STAND FOR VACUUM CLEANER

JIANGSU MIDEA CLEANING AP...

1. A charging stand for a vacuum cleaner, comprising:a body having a battery charger; and
a blade vertically disposed on the body, wherein the blade extends curvedly along a length direction of the blade and is configured to cut off hairs wound around a brushroll of the vacuum cleaner.

US Pat. No. 10,136,785

VACUUM CLEANER HAVING A FILTER CLEANING MECHANISM

SHOP VAC CORPORATION, Wi...

1. A vacuum cleaner having a filter cleaning mechanism, comprising:a housing having an exterior side and an interior side, and a channel extending through the housing from the exterior side to the interior side;
a vacuum pump to draw air into the interior side of the housing;
a vacuum filter disposed on the interior side of the housing to filter the air;
a filter brush contacting a side of the vacuum filter;
a rod extending slidably through the channel and coupled to the filter brush; and
a handle coupled to the rod, wherein movement of the handle slides the rod through the channel and moves the filter brush along the side of the vacuum filter to remove debris from the filter, wherein the handle rotates from a folded position against the exterior side of the housing to an upright position; and
wherein the handle comprises a cam to translate rotation of the handle into linear movement of the handle.

US Pat. No. 10,136,781

FLOOR CLEANER, AND CLEANING MECHANISM FOR CLEARING CLEANING ROLLER

HiZero Technologies Co., ...

1. A cleaning mechanism for clearing a cleaning roller of a cleaner, the cleaning mechanism comprising:a cleaning roller for cleaning ground;
a clearing component operating to clear the cleaning roller;
a scraper having an arc-shaped surface facing the cleaning roller, wherein the scraper defines an opening in which the clearing component is disposed; and
a power unit, wherein:
the clearing component comprises a rotation body and a plurality of clearing elements disposed on the rotation body for clearing a surface of the cleaning roller,
the power unit operates to drive the rotation body and each of the plurality of clearing elements to rotate along with the cleaning roller in a same direction,
a top surface of the scraper and a base shell, spaced apart from the scraper, define the opening, and
the scraper is disposed between the cleaning roller and a trash bin.
US Pat. No. 10,137,201

PROCESS FOR FORMULATING AN ANIONIC AGENT

DICERNA PHARMACEUTICALS, ...

1. A method of producing a particle comprising an anionic agent the method comprising:(a) combining in an acidic aqueous solution (i) a modified lipid which prevents particle aggregation during lipid-anionic agent particle formation and (ii) a cationic lipid, in an amount sufficient for a complex to form;
(b) combining the complex of step (a) with an anionic agent;
(c) combining a neutral aqueous solution with the complex-anionic agent of step (b) to form a complex-anionic agent aqueous suspension;
(d) forming a solution or suspension comprising an alcohol and at least one lipid selected from the group consisting of a neutral lipid, a sterol, a cationic lipid and a modified lipid which prevents particle aggregation during lipid-anionic agent particle formation; and
(e) adding the solution or suspension of step (d) to the complex-anionic agent aqueous suspension of step (c), thereby causing the concentration of the alcohol in the complex-anionic agent aqueous suspension to gradually increase from 0% to up to no more than 40% (v/v) as more of the solution of step (d) is added to the complex-anionic agent aqueous solution of step (c), thereby producing a particle comprising an anionic agent.
US Pat. No. 10,138,491

PROTEIN HAVING GLYCOALKALOID BIOSYNTHETIC ENZYME ACTIVITY AND GENE ENCODING THE SAME

KIRIN HOLDINGS KABUSHIKI ...

1. A transformed solanaceous plant having reduced glycoalkaloid content in which the expression of a gene encoding a protein having glycoalkaloid biosynthetic enzyme activity is suppressed, wherein the suppression of the gene is induced by RNAi, and wherein the gene comprises a DNA selected from the group consisting of (a) to (c);(a) DNA consisting of the nucleotide sequence shown in SEQ ID NO: 2, 4, 19 or 21;
(b) DNA that consists of a nucleotide sequence having 90% or more sequence identity to the nucleotide sequence shown in SEQ ID NO: 2, 4, 19 or 21; and
(c) DNA consisting of a degenerate isomer of the nucleotide sequence shown in SEQ ID NO: 2, 4, 19 or 21.
US Pat. No. 10,136,957

LEAK RESISTANT ARTICLE

Ansell Limited, Victoria...

1. A leak-resistant elastomeric barrier comprising:an elastomeric barrier comprising elastomeric polymer, having two sides, and coated on at least a portion of a first side with highly hydrophobic coating such that the initial contact angle with water at 23±2° C. is about 130° or more, and that contact angle does not decay by more than about 10% over 40 minutes.
US Pat. No. 10,138,495

BIO-PRODUCTION OF LENTIVIRAL VECTORS

Calimmune, Inc., Tucson,...

1. A recombinant plasmid comprising a nucleotide sequence having at least 90% identity to the sequence of SEQ ID NO: 1.
US Pat. No. 10,138,239

PREPARATION METHOD OF CRYSTALLINE FORM A OF PCI-32765

Crystal Pharmatech Co. LT...

1. A preparation method of PCI-32765 crystalline Form A wherein the preparation method comprises the following steps:1) preparing a PCI-32765 free base solution by dissolving the free base solid of PCI-32765 in a solvent;
2) adding dropwise the solution prepared by step 1) into an anti-solvent at a temperature of 0-20° C., then stirring the mixture at a temperature of 0-20° C. and adding seed crystals of PCI-32765 Form A to form a suspension; or adding dropwise the solution prepared by step 1) into a suspension containing seed crystals of PCI-32765 Form A at a temperature of 0-20° C. to form a suspensions;
3) continuously stirring the suspension obtained by step 2) and aging the suspension until a crystal slurry is obtained;
4) filtering the crystal in step 3) to obtain a filter cake, then washing and drying the filter cake to obtain a powder of PCI-32765 crystalline Form A.
US Pat. No. 10,138,496

VECTORS WITH MODIFIED INITIATION CODON FOR THE TRANSLATION OF AAV-REP78 USEFUL FOR PRODUCTION OF AAV

uniQure IP B.V., Amsterd...

1. A method of producing a recombinant parvoviral viron in an insect cell comprising, transfecting and insect cell with a nucleotide sequence encoding parvoviral Rep proteins Rep78 and Rep52, the nucleotide sequence comprising a Rep78 coding sequence and a Rep52 coding sequence, the Rep78 coding sequence and the Rep52 coding sequence being operably linked to expression control sequences for expression of both a Rep78 protein and a Rep52 protein in an insect cell; wherein the Rep52 coding sequence is comprised within the Rep78 coding sequence, and wherein a molar ratio of Rep78 and Rep52 in the range of 1:10 to 10:1 is produced when the nucleotide sequence is expressed in the insect cell.
US Pat. No. 10,141,574

CARBON NANOTUBE DISPERSION LIQUID AND MANUFACTURING METHOD THEREOF

LG CHEM, LTD., Seoul (KR...

1. A carbon nanotube dispersion comprising:bundle-type carbon nanotubes;
a dispersion medium; and
partially hydrogenated nitrile rubber having a residual double bond (RDB) value of 0.5% by weight to 40% by weight calculated according to the following Mathematical Formula 1,
wherein dispersed particle diameters of the carbon nanotubes have a particle size distribution D50 of 3 ?m to 10 ?m:
RDB (% by weight)=BD weight/(BD weight+HBD weight)×100  [Mathematical Formula 1]
in Mathematical Formula 1, BD is a conjugated diene-derived structure unit and HBD is a hydrogenated conjugated diene-derived structure unit.
US Pat. No. 10,138,498

RECOMBINANT MICROORGANISMS FOR ENHANCED PRODUCTION OF MEVALONATE, ISOPRENE, AND ISOPRENOIDS

Danisco US Inc., Palo Al...

1. Recombinant bacterial or yeast cells capable of increased production of isoprenoids, wherein the cells are engineered by(i) modulation of citrate synthase activity such that the activity of citrate synthase is Decreased;
(ii) modulation of the activities of one or more of the following enzymes such that:
(a) phosphotransacetylase activity is attenuated;
(b) acetate kinase activity is attenuated; and/or
(c) lactate dehydrogenase activity is attenuated; and
(iii) modulation of the activity of two or more of the following enzymes such that (d) malate dehydrogenase activity is increased, (e) pyruvate dehydrogenase activity is increased, and/or (f) phosphoenolpyruvate carboxylase activity is attenuated, resulting in increased carbon flux towards mevalonate production;
wherein the cells further comprise (A) one or more nucleic acids encoding one or more mevalonate (MVA) pathway polypeptides; and (B) one or more nucleic acids encoding a polyprenyl pyrophosphate synthase; and
wherein the cells produce increased amounts of isoprenoids compared to isoprenoid-producing cells that do not comprise (i-iii).
US Pat. No. 10,137,218

DISINFECTION SYSTEM OF CONTACT LENS

MENICON CO., LTD., Nagoy...

1. A method for disinfecting a contact lens comprising:contacting a contact lens with a contact lens disinfecting solution having a pH of from 6 to 8 and including 1 to 10% hydrogen peroxide and 0.1% to 5% by weight of at least one of an organic carboxylic acid and a salt thereof, wherein the organic carboxylic acid includes a structure in which a hydroxyl group and a carboxyl group are bonded to one carbon atom, and
neutralizing the hydrogen peroxide in the disinfecting solution by contacting the disinfecting solution with a metal catalyst for a treatment duration in which the level of hydrogen peroxide in the disinfecting solution is reduced to a concentration of 200 ppm or less, the treatment duration being a shorter time period than a period that would otherwise be required to neutralize hydrogen peroxide to the same concentration with the metal catalyst in a like contact lens disinfecting solution without the organic carboxylic acid.
US Pat. No. 10,138,499

METHODS FOR IMPROVING THE EFFICIENCY OF SIMULTANEOUS SACCHARIFICATION AND FERMENTATION REACTIONS

DANISCO US INC., Palo Al...

1. A method for simultaneous saccharification and fermentation (SSF) comprising culturing a complete fermentation medium, said complete fermentation medium comprising at least one fermenting microorganism, at least one xylan-containing biomass, at least one cellulase, at least one hemicellulase, at least one retaining ?-xylosidase, and at least one inverting ?-xylosidase, for a period and under conditions suitable for producing a fermentation product, which is an alcohol, wherein the at least one inverting ?-xylosidase comprises an Fv43D polypeptide having at least 90% sequence identity to SEQ ID NO:2, or to residues 21 to 350 of SEQ ID NO:2, and the complete fermentation medium comprises a greater amount of the at least one inverting ?-xylosidase than that of the at least one retaining ?-xylosidase on a mole basis.
US Pat. No. 10,138,504

PRODUCTION OF MALONYL-COA DERIVED PRODUCTS VIA ANAEROBIC PATHWAYS

Lallemand Hungary Liquidi...

1. A recombinant yeast microorganism comprisingone or more engineered metabolic pathways to convert a carbohydrate source to a malonyl-CoA derived product,
wherein the one or more engineered metabolic pathways comprises
(a) the conversion of phosphoenolpyruvate to oxaloacetate by a phosphoenolpyruvate carboxykinase and
(b) the conversion of oxaloacetate and acetyl-CoA to malonyl-CoA and pyruvate by a heterologous transcarboxylase Enzyme Commission Number 2.1.3.1;
wherein the one or more engineered metabolic pathways further comprises downregulation or deletion of native pyruvate decarboxylase, and wherein the one or more engineered metabolic pathway further comprises heterologous pyruvate formate lyase.
US Pat. No. 10,138,507

MANUFACTURING METHODS FOR PRODUCTION OF RNA TRANSCRIPTS

ModernaTX, Inc., Cambrid...

1. A method for producing a purified composition comprising a capped RNA transcript for a gene of interest, the method comprising:(a) providing a sample comprising a linear, non-amplified DNA template, the DNA template comprising an RNA polymerase promoter sequence operatively linked to a target sequence coding for the gene of interest, a poly A tail sequence of 60-160 nucleotides, an endonuclease recognition site sequence immediately downstream of the poly A tail sequence, and a 5? untranslated region (UTR) and/or a 3? UTR;
(b) contacting the sample with a RNA polymerase and ribonucleotides under conditions sufficient for vitro transcription to produce a first composition comprising an uncapped RNA transcript wherein at least 80% of the RNA transcript is full-length uncapped RNA transcript;
(c) purifying the uncapped RNA transcript using oligo dT affinity purification;
(d) capping the uncapped RNA transcript by contacting the RNA transcript with quanlyltransferase, s-adenosyl-L-methionine, guanosine triphosphate, and 2?-O-methyltransferase to produce a second composition comprising a capped RNA transcript;
(e) purifying the capped RNA transcript from the second composition by anion exchange chromatography; and
(f) filtering the capped RNA transcript by ultrafiltration or tangential flow filtration, thereby producing the purified composition comprising a capped RNA transcript,wherein the method does not comprise treating the composition with DNase.
US Pat. No. 10,138,511

ARRAYS OF MICROPARTICLES AND METHODS OF PREPARATION THEREOF

BioArray Solutions Ltd., ...

1. A method of retaining a population of charged beads in recesses in a surface of a semiconductor comprising depositing a first charged polymer on the surface of the semiconductor, said first charged polymer having a charge of opposite sign to the charged beads, depositing the beads onto the surface of the semiconductor, and depositing a second charged polymer on the surface of the semiconductor, said second charged polymer having a charge of opposite sign to the first charged polymer.
US Pat. No. 10,138,513

METHOD AND DEVICE FOR AMPLIFYING AND DETECTING GENE USING GRAPHENE HEATER

ELECTRONICS AND TELECOMMU...

1. A gene amplifying and detecting device, comprising:a gene amplifying chip including a chamber formed therein, the gene amplifying chip having a first sidewall and a second sidewall opposite to the first sidewall;
a reaction solution in the chamber and including a fluorescent material;
a light source adjacent to the first sidewall of the gene amplifying chip;
a light detector located adjacent to the second sidewall of the gene amplifying chip; and
a first graphene heater adjacent to the first sidewall of the gene amplifying chip so as to heat the reaction solution to cause a circulating flow of the reaction solution by convection,
wherein the first graphene heater is positioned between the light source and the chamber to transmit light generated from the light source into the chamber.
US Pat. No. 10,138,517

MANIPULATION OF MICROPARTICLES IN MICROFLUIDIC SYSTEMS

CALIPER LIFE SCIENCES, IN...

1. A method of modifying flow in a microchannel, the method comprising:flowing a first particle set into the microchannel;
performing a first assay in the microchannel;
moving the first particle set within the microchannel and flowing a second particle set stacked against the first particle set into the microchannel, thereby altering the hydrodynamic resistance in the microchannel; and,
performing a second assay in the microchannel.
US Pat. No. 10,138,521

TREATMENT AND DIAGNOSIS OF EPIGENETIC DISORDERS AND CONDITIONS

Murdoch Childrens Researc...

1. A method of detecting methylation in Fragile X-related Epigenetic Element 2(E) (FREE2(E)) in genomic DNA of a human subject, the method comprising:(a) obtaining isolated genomic DNA from the human subject,
(b) amplifying wholly or partially
FREE2(E) consisting of the nucleotide sequence of SEQ ID NO:49 or a modified SEQ ID NO:49 in which methylated cytosine(s) in SEQ ID NO:49 are converted to uracil(s) using a first primer complementary to a first region of SEQ ID NO:49 or to the modified SEQ ID NO:49 sequence in which methylated cytosine(s) have been converted to uracil(s) and a second primer complementary to a second region of SEQ ID NO:49 or to the modified SEQ ID NO:49 sequence in which methylated cytosine(s) have been converted to uracil(s), wherein the second primer is non-overlapping with the first primer; and
(c) detecting methylation in the wholly or partially amplified FREE2(E).
US Pat. No. 10,138,522

IDENTIFICATION OF CATTLE AT RISK OF HIGH ALTITUDE PULMONARY HYPERTENSION

VANDERBILT UNIVERSITY, N...

7. A method of breeding cattle, comprising,a) subjecting a nucleic acid-containing sample from a head of cattle to nucleic acid sequence analysis;
b) analyzing the nucleotide present at positions 1816 and/or 1828 in exon 12 of the bovine EPAS1 gene;
c) detecting a G allele at position 1816 in exon 12 of the bovine EPAS1 gene and/or a G allele present at position 1828 in exon 12 of the bovine EPAS1 gene; and
d) breeding the head of cattle with a G allele at position 1816 in exon 12 of the bovine EPAS1 gene and/or a G allele present at position 1828 in exon 12 of the bovine EPAS1 gene.
US Pat. No. 10,138,526

MOLECULAR MARKERS ASSOCIATED WITH STEM CANKER RESISTANCE IN SOYBEAN

Monsanto Technology LLC, ...

1. A method of producing a population of soybean plants that comprises a genotype associated with a stem canker resistance phenotype, the method comprising:(i) genotyping a first population of soybean plants, wherein the first population contains at least one allele associated with the stem canker resistance phenotype, wherein the allele is located in at least one stem canker resistance marker locus, wherein the stem canker resistance marker locus is in a linkage group Dlb genomic region , and wherein said genomic region is flanked by and including:
a) loci NGMAX008369670 and NGMAX008369689;
b) loci NGMAX008369675 and NGMAX008369689;
c) loci NGMAX008369673 and NGMAX008369689;
d) loci NGMAX008369676 and NGMAX008369689;
e) loci NGMAX008369683 and NGMAX008369689;
f) loci NGMAX008369675 and NGMAX008369686;
g) loci NGMAX008369673 and NGMAX008369686;
h) loci NGMAX008369676 and NGMAX008369686; or,
i) loci NGMAX008369683 and NGMAX008369686,
(ii) selecting from said first population of soybean plants based upon said genotyping one or more soybean plants comprising the at least one allele associated with a stem canker resistance phenotype; and
(iii) producing offspring from the one or more selected soybean plants of the first population of soybean plants by crossing the selected soybean plant with another soybean plant,
thereby producing a second population of soybean plants comprising a genotype associated with a stem canker resistant phenotype.
US Pat. No. 10,138,527

METHOD FOR MONITORING DIFFERENTIATION INTO CARDIAC MUSCLE CELLS

OLYMPUS CORPORATION, Tok...

1. A method for monitoring differentiation into cardiac muscle cells comprising:introducing, into cells, a reporter gene of luminescent protein configured to vary in luminescence intensity according to an expression of a myocardial differentiation marker gene, wherein the reporter gene is a cTnT gene expression specific luminescent vector, wherein the cells are stem cells or cardiac progenitor cells;
keeping, in an alive state, the cells into which the reporter gene of luminescent protein were introduced;
acquiring a luminescence image as a still image by imaging light emitted from the cells in a light shielding state;
acquiring sequential images with illuminating the cells, the step of acquiring the sequential images comprising acquiring a bright-field image of the cells;
associating biological information obtained from the sequential images with biological information obtained from the still image;
conducting a motion analysis based on the bright-field image, wherein the motion analysis is conducted by use of an image correlation method;
analyzing beating of the cells by the motion analysis;
analyzing expression of the myocardial differentiation marker gene based on the luminescence image; and
assessing a relationship between the beating and the expression.
US Pat. No. 10,138,272

MATRIPTASE AND U-PLASMINOGEN ACTIVATOR SUBSTRATES AND OTHER CLEAVABLE MOIETIES AND METHODS OF USE THEREOF

CytomX Therapeutics, Inc....

1. An isolated polypeptide comprising a cleavable moiety (CM), wherein the CM comprises the amino acid sequence of SEQ ID NO: 363, wherein the CM is a substrate for a protease, wherein the isolated polypeptide comprises at least one moiety (M) selected from the group consisting of a moiety that is located amino (N) terminally to the CM (MN), a moiety that is located carboxyl (C) terminally to the CM (MC), and combinations thereof, and wherein the MN or MC is selected from the group consisting of an antibody or antigen binding fragment thereof (AB), a therapeutic agent, an antineoplastic agent, a toxic agent, a drug, and a detectable label.
US Pat. No. 10,138,277

VIRUS-LIKE PARTICLES AND METHODS OF USE

The United States of Amer...

1. An isolated polynucleotide encoding an altered viral protein selected from the group consisting of:a. an alphavirus E2 protein comprising at least one alteration, relative to the wild-type amino acid sequence, at one or more amino acid locations corresponding to at least one amino acid position selected from the group consisting of H170, K200, K233, K234, R251, and H256 of Chikungunya E2 protein; and
b. an alphavirus capsid protein comprising at least one alteration, relative to the wild type sequence, in the Nuclear Localization Signal (NLS);
wherein the altered protein is capable of self-assembling into a virus like particle (VLP); and,
wherein the at least one alteration enhances production of VLPs.
US Pat. No. 10,138,278

FLUOROGEN ACTIVATING AND SHIFTING TAG (FAST)

CENTRE NATIONAL DE LA REC...

1. A a functional photoactive yellow protein (PYP) polypeptide comprising the sequence of SEQ ID NO: 48, or a sequence having at least 70% identity with the sequence of SEQ ID NO: 48, wherein said sequence further comprises one or more amino acid substitutions in the amino acid region at position 94-101 with reference to SEQ ID NO: 48, one of said substitutions being a proline at position 97 with reference to SEQ ID NO: 48, and wherein said polypeptide binds reversibly a fluorogenic chromophore with:a KD ranging from about 0.05 to about 10 ?M when measured at a temperature of about 25° C.; and/or
a koff ranging from about 1 to about 50 s?1 when measured at a temperature of about 25° C.; and/or
a kon ranging from about 0.1×107 to about 50×107 M?1s?1 when measured at a temperature of about 25° C.
US Pat. No. 10,138,279

COMPOSITIONS AND METHODS FOR BACILLUS ANTHRACIS VACCINATION

Regents of the University...

1. A method of inducing an immune response to Bacillus anthracis (B. anthracis) in a subject comprising intranasally administering an immunogenic composition comprising:A) a nanoemulsion, wherein the nanoemulsion comprises:
1. oil;
2. water;
3. ethanol;
4. a polysorbate surfactant selected from the group consisting of polyoxyethylene sorbitan monooleate and polyoxyethylene sorbitan monolaurate; and
5. cetylpyridinium chloride (CPC); and
B) recombinant protective antigen (rPA) of B. anthracis to the subject, wherein the administering generates a B. anthracis-specific immune response comprising generation of a serum anthrax lethal toxin (LeTx)-specific neutralizing antibody titer that is at least 10 fold greater than the serum LeTx-specific neutralizing antibody titer generated in a control subject administered an equal amount of rPA suspended in saline.
US Pat. No. 10,138,281

STABLE AMYLOID BETA MONOMERS AND OLIGOMERS

ALZINOVA AB, Gothenburg ...

1. A polypeptide, which is an amyloid precursor protein (APP), whereini) the amino acid alanine in position 692, as defined by the amino acid sequence of the human APP in SEQ ID NO: 12 is replaced with a cysteine; and
ii) the amino acid alanine in position 701, as defined by said amino acid sequence of said human APP in SEQ ID NO: 12 is replaced with a cysteine, wherein cleavage of said polypeptide derives a peptide fragment comprising the amino acid sequence L-V-F-F-C (SEQ ID NO: 13) corresponding to amino acids 17 to 21 of SEQ ID NO: 4 and the amino acid sequence C-I-I-G-L-M-V (SEQ ID NO: 14) corresponding to amino acids 30 to 36 of SEQ ID NO: 4, said peptide fragment comprising:
exactly two cysteines corresponding to Cys21 and Cys30 in SEQ ID NO: 4; and
exactly one disulfide bond, said exactly one disulfide bond is between said two cysteines corresponding to Cys21 and Cys30 in SEQ ID NO: 4, wherein said peptide fragment is resistant towards fibrillogenesis.
US Pat. No. 10,138,284

NON-STANDARD INSULIN ANALOGUES

Case Western Reserve Univ...

1. An insulin analogue comprising the insulin B-chain polypeptide containing a Cyclohexanylalanine substitution at a position corresponding to position B24 of wild type insulin and a glutamic acid substitution at a position corresponding to position B29 of wild type insulin; wherein optionally the insulin analogue comprises a lysine substitution at a position corresponding to position B3 of wild type insulin.
US Pat. No. 10,138,285

DIAGNOSIS OF A NEUROAUTOIMMUNE DISEASE COMPRISING MEASURING AUTOANTIBODIES TO FLOTILLIN1 AND/OR FLOTILLIN2

EUROIMMUN MEDIZINISCHE LA...

1. A method for detecting the presence of an autoantibody in a subject, comprising:obtaining a sample from a subject;
exposing a complex comprising 1) flotillin1 or a variant thereof and 2) flotillin2 or a variant thereof, which is immobilized on a solid carrier, to the sample from the subject; and
detecting whether the autoantibody is present in the sample by detecting the binding between the autoantibody and the complex.
US Pat. No. 10,138,286

METHODS AND COMPOSITIONS FOR INHIBITING THE EFFECTS OF AMYLOID BETA OLIGOMERS

The Board of Trustees of ...

1. A composition comprising a LILRB2 polypeptide consisting of the first two Ig-like domains of LILRB2, which are residues 24-223 of SEQ ID NO: 3; and an Fc domain.
US Pat. No. 10,138,290

PROCESS FOR PROTEIN PRODUCTION

Novo Nordisk Healthcare A...

1. A large-scale, continuous perfusion process for producing a haemostasis protein, comprisingproviding a cell culture in suspension in a bioreactor, wherein the bioreactor is in fluid communication with a filter module, wherein the bioreactor volume is at least 500 L, and wherein the filter module mesh size is from about 0.1 ?m to about 2.9 ?m;
providing a dissolved oxygen concentration in the suspension of around 20% to 100%; and
flowing the cell culture suspension across the filter module in an alternating tangential flow, in order to separate haemostasis protein produced by the cell culture from the cells; and
culturing the cells to a target cell density below 80×106 cell s/ml.
US Pat. No. 10,138,292

CELL CULTURE MEDIUM

BIOLAMINA AB, Sundbyberg...

1. A system for maintaining human pluripotent stem cells, comprising:a chemically defined and xeno-free cell culture medium comprising from greater than zero to 3.9 ng/mL of basic fibroblast growth factor (bFGF), wherein the cell culture medium does not contain (1) insulin or an insulin substitute, and does not contain (2) transferrin or a transferrin substitute; and
a container having a substrate thereon, the substrate containing laminin-521 or laminin-511 for providing support to the human pluripotent stem cells.
US Pat. No. 10,138,294

TEMPERATURE SHIFT FOR HIGH YIELD EXPRESSION OF POLYPEPTIDES IN YEAST AND OTHER TRANSFORMED CELLS

ALDERBIO HOLDINGS LLC, L...

1. A method of producing a recombinant multi-subunit complex in yeast cells, comprising:(a) culturing at a first temperature yeast cells comprising one or more genes that encode said multi-subunit complex; and
(b) culturing said yeast cells at a second temperature and allowing said yeast cells to produce said multi-subunit complex;
wherein said first temperature is between 27.5° C. and 28.5° C., and said second temperature is between 30° C. and 31° C.,
wherein said method increases the yield of said protein and/or decreases the relative abundance of one or more product-associated variants relative to the same method effected without a difference between said first temperature and said second temperature, and
wherein the promoter or promoters which regulate the transcription of the one or more genes that encode said multi-subunit complex are not temperature inducible.
US Pat. No. 10,138,298

ANTI-IL-2 ANTIBODIES AND COMPOSITIONS AND USES THEREOF

The Regents of the Univer...

1. An isolated antibody or antigen-binding portion thereof that specifically binds human IL-2, said antibody comprising: a heavy chain complementarity determining region 1 (HCDR1) comprising SEQ ID NO:127, a heavy chain complementarity determining region 2 (HCDR2) comprising SEQ ID NO:130, a heavy chain complementarity determining region 3 (HCDR3) comprising SEQ ID NO:132, a light chain complementarity determining region 1 (LCDR1) comprising SEQ ID NO:133, a light chain complementarity determining region 2 (LCDR2) comprising SEQ ID NO:134, and a light chain complementarity determining region 3 (LCDR3) comprising SEQ ID NO:135.
US Pat. No. 10,138,303

HETERODIMERIC PROTEINS AND METHODS FOR PRODUCING AND PURIFYING THEM

RINAT NEUROSCIENCE CORP.,...

1. A heterodimeric protein comprising:a hinge region comprising a first immunoglobulin-like hinge polypeptide and a second immunoglobulin-like hinge polypeptide which interact together to form a dimeric hinge interface, wherein electrostatic interactions between one or more charged amino acids within the hinge interface favor interaction between the first and second hinge polypeptides over interaction between two first hinge polypeptides or two second hinge polypeptides, thereby promoting heterodimer formation over homodimer formation, wherein the hinge region is a human IgG1 hinge region, wherein the first hinge polypeptide comprises at least one amino acid modification relative to a wild-type IgG hinge region; wherein the wild-type amino acid in the first hinge polypeptide is replaced with an amino acid having an opposite charge to the corresponding amino acid in the second hinge polypeptide, wherein the amino acid modification in the hinge region comprises Asp221 as shown at FIG. 6A, and further comprising an immunoglobulin-like CH3 region comprising a first CH3 polypeptide fused to the first hinge polypeptide and a second CH3 polypeptide fused to the second hinge polypeptide, wherein the first CH3 polypeptide and the second CH3 polypeptide comprise at least one amino acid modification relative to a wild-type IgG1 CH3 region sequence at a position selected from the group consisting of Tyr349, Leu368, Phe405, and Lys409 (EU numbering scheme) as shown at FIG. 10.
US Pat. No. 10,137,280

SYSTEM AND METHOD FOR TREATMENT OF HEMORRHAGIC STROKE

InCube Labs, LLC, San Jo...

1. A method for treating a cerebral aneurysm, the method comprising:advancing a microcatheter having a delivery lumen to the site of the aneurysm;
delivering a carrier containing a first agent and a second agent to the aneurysm through the delivery lumen of the microcatheter so as to at least partially fill a sac of the aneurysm; wherein the first agent comprises an anti-inflammatory agent and the second agent comprises a member of the transforming growth factor-? family; and
controllably releasing the first and second agents from the carrier to the site of the aneurysm,
wherein the carrier comprises a first gel component including the first agent and a second gel component including the second agent,
wherein the first gel component has a first viscosity selected to release the first agent at a first rate of release, and
wherein the second gel component has a second viscosity different from the first viscosity, the second viscosity being selected to release the second agent at a second rate of release slower than the first rate of release.
US Pat. No. 10,138,306

METHACRYLIC ACID PRODUCTION METHOD

University of Georgia Res...

1. A method of producing methacrylic acid comprising reacting a substrate with a palladium nitrate catalyst comprising a hydrotalcite under conditions sufficient to produce methacrylic acid in a single step, wherein the substrate is selected from the group consisting of 2-hydroxyisobutyric acid or salts thereof, itaconic acid or salts thereof, citric acid or salts thereof, citramalic acid or salts thereof, and combinations thereof.
US Pat. No. 10,138,566

SEALING ANODIZED ALUMINUM USING A LOW-TEMPERATURE NICKEL-FREE PROCESS

MacDermid Acumen, Inc., ...

1. A method for sealing an anodized aluminum or anodized aluminum alloy surface comprising:(i) contacting the anodized surface with a sealing composition comprising a source of lithium ions, a source of fluoride ions, and a complexing agent, followed by;
(ii) contacting the anodized surface with a passivation composition wherein the passivation composition comprises a source of metal ions and a complexing agent;
wherein the surface of the anodized aluminum or anodized aluminum alloy becomes corrosion resistant, and
wherein the temperature of the passivation composition is less than 80° C.
US Pat. No. 10,138,310

PREPARATION OF LLDPE RESINS AND FILMS HAVING LOW GELS

Equistar Chemicals, LP, ...

1. A process for making a linear low density polyethylene resin comprising the steps of:copolymerizing ethylene with a comonomer selected from 1-butene and 1-hexene, and wherein the comonomer used in an amount within the range of 5-10% by weight of ethylene to produce a linear low density polyethylene;
wherein the copolymerizing step is performed in the presence of hydrogen, an inert gas selected from nitrogen and carbon dioxide, and
a Ziegler-Natta catalyst comprising:
a MgCl2 support,
a Ti(IV) complex, and
an internal electron donor comprising a cyclic ether; and
wherein Ziegler-Natta catalyst is formed by first contacting the MgCl2 support with the Ti(IV) complex to form an intermediate product, and the intermediate product is then contacted with the internal electron donor to produce the Ziegler-Natta catalyst;
wherein the Ziegler-Natta catalyst has an Mg/Ti molar ratio greater than or equal to 7, and an internal electron donor/Ti molar ratio between 5 and 20; and
wherein the linear low density polyethylene resin has a gel defect area less than or equal to 25 ppm;
wherein the catalyst is characterized by an X-ray diffraction spectrum which, in the range of 2? diffraction angles between 5.0° and 20.0°, has at least three main diffraction peaks: 2? of 7.2±0.2°, 11.5±0.2°, and 14.5±0.2°; and
wherein the peak at 2? of 7.2±0.2° is most intense and the peak at 11.5±0.2° has an intensity less than 90% of the intensity of the peak at 2? of 7.2±0.2°.
US Pat. No. 10,138,320

COMB-BLOCK HIGH DENSITY POLYETHYLENES AND METHODS OF MAKING THEM

ExxonMobil Chemical Paten...

1. A process for making a polyethylene composition comprising:contacting, at a temperature of at least 100° C., ethylene with a first salan catalyst precursor and an activator to form branched vinyl/vinylidene-terminated high density polyethylene (“bVT-HDPE”) having a number average molecular weight (Mn) of at least 5,000 g/mole;
contacting, at a temperature of at least 100° C., the bVT-HDPE with ethylene and a second metallocene catalyst precursor and an activator to form a comb-block HDPE; and
isolating a polyethylene composition.
US Pat. No. 10,139,345

MAGNETIC AND RAMAN BASED METHOD FOR PROCESS CONTROL DURING FABRICATION OF CARBON NANOTUBE BASED STRUCTURES

THE UNITED STATES OF AMER...

13. A method for process control during fabrication of carbon nanotube structures, the method comprising:providing a carbon nanotube starting material;
forming the composite structure with the carbon nanotube starting material under one or more fabrication process parameters; and
monitoring a magnetic property of the composite structure while forming the composite structure.
US Pat. No. 10,138,334

DRY WATER SOLUBLE POLYMER PARTICLES

Water Mark Technologies, ...

1. A method of reducing friction during fracturing a subterranean formation, comprising:introducing micronized dry water soluble polymer (DWSP) particles having a mean particle size ranging from about 115 to about 300 microns as a friction reducer directly into a reservoir containing a fracture fluid prior to pumping the fracture fluid from the reservoir into a well bore formed in a subterranean formation, wherein the DWSP particles are dispersed in a fluid that does not dissolve the DWSP particles prior to the introduction into the reservoir, wherein the fluid that does not dissolve the DWSP particles is an oil; and
upon the introduction of the friction reducer, pumping the fracture fluid from the reservoir into the well bore formed in the subterranean formation to fracture the subterranean formation,
wherein a desired reduction in the pressure at the head of the well bore in the subterranean formation is achieved in less than about 30 seconds of pumping the fracture fluid,
wherein the micronized DWSP particles comprise:
a DWSP,
wherein the DWSP is selected from the group consisting of a dry anionic water soluble polymer, a dry cationic water soluble polymer, a dry nonionic water soluble polymer, and mixtures thereof.
US Pat. No. 10,139,361

PROTEOLYSIS DETECTION

The University of Queensl...

1. A method for detecting or monitoring proteolysis of a synthetic proteinaceous matrix comprising:contacting at least a portion of the synthetic proteinaceous matrix with a biological sample, wherein the synthetic proteinaceous matrix is impregnated with an electroactive species, the synthetic proteinaceous matrix is contained in or placed on a support, the synthetic proteinaceous matrix is in contact with at least a portion of a working electrode or a counter electrode, and the biological sample comprises a biological fluid;
applying a potential to the working electrode, thereby generating an electrochemical current through the working electrode;
measuring the electrochemical current at a plurality of times to obtain a plurality of current measurements; and
comparing at least two of the plurality of current measurements wherein a difference between the at least two current measurements is indicative of degradation of the synthetic proteinaceous matrix in the presence of the biological sample.
US Pat. No. 10,138,337

POLYMER/POTASSIUM PERMANGANATE COMPOSITE FILM AND PREPARATION METHOD THEREOF

FUZHOU UNIVERSITY, Fuzho...

1. A process for preparing a polymer/potassium permanganate composite film, comprising the following steps:Step (1): mixing polymethylhydrosiloxane or KH-570 and zinc stearate with potassium permanganate well at a mass ratio of 1-3:1-3:100, then heating the mixture under the temperature of 130-150° C. for 20-40 minutes to obtain a modified potassium permanganate;
Step (2): dissolving 0.15-0.75 g of modified potassium permanganate obtained from step (1) in 20 ml of N,N-dimethyl formamide or tetrahydrofuran, then ultrasonically dispersing the mixture for 10-30 minutes to obtain a modified potassium permanganate solution;
Step (3): dissolving 10-20 g of polymer in 60 ml solvents, then swelling the mixture under the temperature of 70-90° C. for 10-14 hours, adding the modified potassium permanganate solution from step (2) into the mixture, stirring it well to remove air bubbles, and then letting it stand for a certain length of time to obtain a mixed solution;
Step (4): coating the mixed solution obtained from step (3) on a glass plate, vacuum drying it under the temperature of 60-70° C. for 15-25 minutes, then drying it under the temperature of 70-90° C. for 4-6 hours in a drum wind dryer, and finally allowing it to cool down naturally.
US Pat. No. 10,138,594

PARTIALLY FLUORINATED URETHANE BASED COATINGS

THE CHEMOURS COMPANY FC, ...

1. A compound for imparting water repellency and optionally stain release to substrates wherein the compound is prepared by the process comprising:reacting (a) at least one isocyanate group-containing compound selected from the group consisting of diisocyanate and polyisocyanate, or mixture thereof; (b) at least one isocyanate-reactive compound selected from the group consisting of cyclic or acyclic sugar alcohol which is substituted with at least two —R1; —C(O)R1; —(CH2CH2O)n(CH(CH3)CH2O)mC(O)R1; or mixtures thereof; where the cyclic or acyclic sugar alcohol is selected from a saccharide, reduced sugar, aminosaccharide, aldonic acid, and aldonic acid lactone;wherein each n is independently 0 to 20;each m is independently 0 to 20;
m+n is greater than 0;
each R1 is independently a linear or branched alkyl group having 5 to 29 carbons optionally comprising at least 1 unsaturated bond; and
(c) at least one fluorinated isocyanate-reactive compound selected from a fluorinated alcohol, fluorinated thiol, or fluorinated amine.
US Pat. No. 10,138,338

COPOLYESTERS PLASTICIZED WITH POLYMERIC PLASTICIZER

Eastman Chemical Company,...

1. A stretched film comprising:(a) a copolyester having a minimum crystallization halftime (t1/2min) of at least 8.6 minutes,
wherein the copolyester comprises:
(i) a diacid component comprising at least 50 mole percent of residues of terephthalic acid, naphthalenedicarboxylic acid, 1,4-cyclohexanedicarboxylic acid, isophthalic acid, or mixtures thereof; and
(ii) a diol component comprising at least 80 mole percent of residues of a diol containing 2 to 10 carbon atoms,
wherein the diacid component is based on 100 mole percent of total diacid residues in the copolyester and the diol component is based on 100 mole percent of total diol residues in the copolyester; and
(b) a polyester plasticizer having a weight-average molecular weight (Mw) of 900 to 12,000 g/mol,
wherein the polyester plasticizer comprises:
(i) a diol component comprising residues of a diol having 2 to 8 carbon atoms; and
(ii) a diacid component comprising residues of a dicarboxylic acid having 4 to 12 carbon atoms;
wherein the film comprises 90 to 99.9 weight percent of the copolyester and 0.1 to 10 weight percent of the polyester plasticizer;
wherein the film has a glass transition temperature of from 40 to 150° C. and the film is stretched at temperatures 5° C. to 80° C. above its glass transition temperature (Tg);
wherein the stretched film has a thickness of 25 to 75 micrometers;
wherein the film is stretched from 2 to 6 times its original measurements; and
wherein the film is clear.
US Pat. No. 10,138,339

SOLAR CELL BACK SHEET FILM AND METHOD FOR PRODUCING THE SAME

FUJIFILM Corporation, To...

1. A film for a solar cell back sheet comprising:a substrate film comprising a polyester, and having a thickness of from 25 ?m to 300 ?m;
a white layer provided directly on at least one surface of the substrate film and comprising a coating film of an aqueous composition for the white layer comprising:
a white pigment,
a first aqueous binder, and
an inorganic oxide filler having a volume average particle size of from 10 nm to 700 nm; and
an adhesive protective layer provided on the white layer and comprising a coating film of an aqueous composition for the adhesive protective layer comprising a second aqueous binder,
wherein:
the white pigment comprises at least one selected from the group consisting of titanium oxide, barium sulfate, aluminum oxide, calcium carbonate, kaolin and talc;
the first aqueous binder comprises at least one selected from the group consisting of polyolefin, polyurethane, polyvinyl alcohol, a polyacrylic and a polyester;
the inorganic oxide filler comprises at least one selected from the group consisting of silica, magnesium oxide and tin oxide;
the second aqueous binder comprises at least one selected from the group consisting of polyolefin, polyurethane, polyvinyl alcohol, a polyacrylic and a polyester; and
the substrate film, the white layer, and the adhesive protective layer are adjacent in this order.
US Pat. No. 10,138,341

USE OF EVAPORATIVE COOLANTS TO MANUFACTURE FILLED POLYURETHANE COMPOSITES

Boral IP Holdings (Austra...

1. A method of making a polyurethane composite, comprising:introducing, in a continuous mold cavity formed by an interior mold surface of two opposed belts, a mixture of:
(1) at least one isocyanate selected from the group consisting of diisocyanates, polyisocyanates, and mixtures thereof,
(2) at least one polyol,
(3) an inorganic filler,
(4) water, and
(5) an evaporative coolant having a boiling point of ?30° C. to 40° C., wherein the evaporative coolant is present in an amount of 0.1% to 2% by weight based on a total weight of polyols in the mixture;
wherein the inorganic filler is dispersed within the mixture to form a cell structure that enables the evaporative coolant to migrate to an interface between the mixture and the interior mold surface;
wherein the at least one isocyanate and the at least one polyol react and generate heat in the mold cavity to form the polyurethane composite, and the temperature of the mixture causes evaporation of the evaporative coolant at the interface thereby removing heat at the interface to reduce surface defects of the polyurethane composite; and
wherein the inorganic filler is present in an amount of 52% to 90% by weight based on a total weight of the polyurethane composite.
US Pat. No. 10,138,342

FORMABLE AND FOAMED AQUEOUS COMPOSITIONS

EASTMAN KODAK COMPANY, R...

1. A foamable aqueous composition that has at least 35% solids and up to and including 70% solids, and comprises:(a) at least 0.05 weight % and up to and including 15 weight % of porous particles, each porous particle comprising a continuous polymeric phase and a first set of discrete pores dispersed within the continuous polymeric phase, the porous particles having a mode particle size of at least 2 ?m and up to and including 50 ?m and a porosity of at least 20 volume % and up to and including 70 volume %, and the continuous polymeric phase having a glass transition temperature greater than 80° C. and comprising a polymer having a viscosity of at least 80 centipoises and up to and including 500 centipoises at a shear rate of 100 sec?1 in ethyl acetate at a concentration of 20 weight % at 25° C.,
(b) at least 20 weight % of a binder material;
(c) at least 0.0001 weight % of one or more additives comprising at least one surfactant;
(d) water; and
(e) at least 0.001 weight % of an opacifying colorant different from all of the one or more (c) additives, which opacifying colorant absorbs electromagnetic radiation having wavelengths of from 350 nm to 800 nm,
all amounts based on the total weight of the foamable aqueous composition,
wherein the foamable aqueous composition can provide a dry opacifying layer having a light blocking value of at least 4 as well as a luminous reflectance that is greater than 40% as measured by the Y tristimulus value.
US Pat. No. 10,137,063

DYE COMPOSITION COMPRISING NONIONIC GUAR GUM OR A NONIONIC DERIVATIVE THEREOF, PROCESS AND DEVICE FOR THE SAME

1. A composition for dyeing human keratin fibers comprising:at least one oxidation dye precursor;
at least one amphoteric or zwitterionic surfactant;
at least one second surfactant chosen from nonionic surfactants, anionic surfactants, or mixtures thereof;
at least one fatty substance other than ceramides chosen from liquid petroleum jelly, C6-C16 alkanes, polydecenes, or esters of fatty acids or of fatty alcohols, which are liquid, or mixtures thereof; and
at least one nonionic guar gum chosen from modified nonionic guar gums modified with C1-C6 hydroxyalkyl groups.
US Pat. No. 10,138,344

PARTICULATE POLYAMIDE, AND METHOD FOR PREPARING THE PARTICULATE POLYAMIDE

RICOH COMPANY, LTD., Tok...

1. A particulate polyamide comprisingpolyamide 3, wherein
the particulate polyamide is porous and has a particle diameter (d50) of from 10 ?m to 1,000 ?m and a particle diameter dispersion degree (Dv/Dn) of not greater than 3.0, wherein Dv represents a volume average particle diameter of the particulate polyamide and Dn represents a number average particle diameter of the particulate polyamide.
US Pat. No. 10,137,064

FOAMING CLEANSER

1. Composition containing, in a physiologically acceptable medium:a surfactant system comprising (i) at least one N—(C6-30)acyl-amino based surfactant, and (ii) at least one amphoteric surfactant chosen from betaines or (C8-C20)alkyl betaines, (C8-C20)alkylamido(C1-C6)alkylbetaines, and mixtures thereof;
at least one non-associative crosslinked copolymers of (meth)acrylic acid, and of (C1-C4)alkyl esters of (meth)acrylic acid; and
a triglyceride oil,
wherein said N—(C6-C30)acyl-amino based surfactant being present in the surfactant system in a major weight amount, and the surfactant system being present in the composition in an amount of less than 15% by weight relative to the total weight of the composition.
US Pat. No. 10,138,345

PROCESS FOR THE PRODUCTION OF EXPANDED POLYESTER FOAM BEADS

BASF SE, Ludwigshafan am...

1. A process for the production of expanded foam beads, the foam beads prepared from pellets comprising a polyester mixture comprisinga) from 60 to 95% by weight, based on components a and b, of a biodegradable polyester based on aliphatic, or a mixture of aliphatic and aromatic, dicarboxylic acids and on aliphatic diols, and
b) from 5 to 40% by weight, based on components a and b, of polylactic acid,
the process comprising the following steps:
(i) providing a suspension of the polyester pellets in a suspension medium,
(ii) impregnating the pellets in the suspension of step (i) with at least one physical blowing agent to provide a suspension of blowing-agent-loaded pellets, wherein the impregnating includes heating the suspension of pellets to an impregnation temperature in a range from 100 to 140° C., with stirring, and
(iii) depressurizing and cooling the suspension obtained in step (ii)-to provide the expanded foam beads, wherein the depressurization and cooling is carried out with a liquid coolant in a ratio of coolant to suspension medium of 0.3 to 20,
wherein the at least one blowing agent is added in step (i), or in step (ii) during the heating, or after the heating, and
wherein, following the heating of step (ii) and the addition of the at least one blowing agent, the heated suspension is maintained at a temperature in a range from the impregnation temperature minus 5° C. to the impregnation temperature plus 2° C. for a period of 15 to 40 minutes; wherein the biodegradable polyester comprises:
A1) from 30 to 100 mol %, based on components A1) and A2), of one or more of an aliphatic dicarboxylic acid selected from the group consisting of succinic acid, adipic acid, sebacic acid and mixtures thereof,
A2) from 0 to 70 mol %, based on components A1) and A2), of terephthalic acid,
B) from 98.5 to 100 mol %, based on components A1) and A2), of 1,4-butanediol or 1,3-propanediol; and
C) from 0.05 to 1.5% by weight, based on components A1), A2) and B), of one or more compounds selected from the group consisting of:
C1) glycerol,
C2) hexamethylene diisocyanate, and
C3) a di- or polyfunctional epoxide.
US Pat. No. 10,137,065

DEODORANT COMPOSITION AND DEODORANT PRODUCT COMPRISING A DEODORANT COMPOSITION

1. A fluid cosmetic composition which is an antiperspirant and/or deodorant composition to be applied to the human skin, the composition being a non-aluminum based composition free from oils and alcohols as an antiseptic, wherein the composition comprises:from 3.0 to 5.0 weight percent of an alkali metal bicarbonate;
from 0.1 to 1.0 weight percent of sodium carbonate, and
from 0.1 to 3.0 weight percent of sodium sulphate, wherein the alkali metal bicarbonate, sodium carbonate and the sodium sulphate are dissolved in water.
US Pat. No. 10,137,066

CONTROLLED RELEASE ACTIVE AGENT CARRIER

Omya International AG, O...

1. A method for introducing one or more active agents to a target environment comprising contacting the target environment with a pharmaceutical formulation comprising one or more active agents so that the pharmaceutical formulation releases a sufficient quantity of the one or more active agents at the target environment, wherein the pharmaceutical formulation comprises an admixture of: (a) a surface reacted natural calcium carbonate in powder or granule form that is a reaction product of natural calcium carbonate with carbon dioxide and one or more acids in an aqueous environment, wherein the carbon dioxide is formed in situ by the acid treatment and/or is supplied from an external source, and wherein the natural calcium carbonate is marble, calcite, chalk, limestone, or any mixture thereof, (b) one or more active agents adsorbed onto and/or absorbed into the surface-reacted calcium carbonate, and (c) one or more pharmaceutically acceptable carriers.
US Pat. No. 10,137,067

TWO-COMPONENT PRODUCTS IN BAGS FOR THE OXIDATIVE DYEING OF KERATIN FIBRES

1. A product for oxidatively changing the color of keratinic fibers, comprising at least two preparations (A) and (B), which are produced separately from one another, whereinthe first preparation (A) comprises, in a cosmetic carrier,
(A1) hydrogen peroxide and
(A2) at least one chelating agent chosen from the group comprising 1-hydroxyethane-1,1-diphosphonic acid (HEDP), ethylenediaminetetramethylenephosphonic acid (EDTMP), diethylenetriaminepentamethylenphosphonic acid (DTPMP), aminotrimethylenephosphonic acid (ATMP), N,N-bis[2-[bis(carboxymethyl)amino]ethyl]glycine, ethylene-diamine-N,N?-disuccinic acid (EDDS), 2-hydroxypropylenediamine-N,N?-disuccinic acid (HPDDS), ethylenediamine-N,N?-diglutaric acid (EDDG), ethylenediamine-N,N?-bis-(orthohydroxyphenyl)acetic acid (EDDHA),
the second preparation (B), in a cosmetic carrier, comprises
(B1) at least one alkalizing agent,
the preparation (A) is produced in a first container (container A), which comprises at least two layers, wherein
an inner layer of the container A comprises a layer of a synthetic polymer (I) and
an outer layer of the container A comprises a metal layer,
preparation (B) is produced in a second container (container B), which comprises at least two layers, wherein
an inner layer of the container B comprises a layer of a synthetic polymer (I) and
an outer layer of the container B comprises a metal layer, wherein
the first container (container A) is a pouch with a total layer thickness of from about 2 to about 400 ?m (micrometers), and/or
the second container (container B) is a pouch with a total layer thickness of from about 2 to about 400 ?m (micrometers).
US Pat. No. 10,138,348

RESIN COMPOSITION AND CURED PRODUCT THEREOF

OMRON CORPORATION, Kyoto...

1. A resin composition comprising:a bisphenol A epoxy resin;
an encapsulated curing agent including a core that contains a curing agent and a shell that covers the core;
a filler; and
a color material,
the filler having a light-transmitting property and being one or more selected from the group consisting of fused silica, crystalline silica, and glass beads,
the bisphenol A epoxy resin being one or more selected from the group consisting of bisphenol A diglycidyl ether, hydrogenated bisphenol A diglycidyl ether, and tetrabromobisphenol A diglycidyl ether,the filler being contained in an amount that is not less than 10 parts by weight and not more than 70 parts by weight relative to 100 parts by weight of the bisphenol A epoxy resin,the color material being carbon black,
the color material being contained in an amount that is not less than 5 parts by weight and not more than 7 parts by weight relative to 100 parts by weight of the bisphenol A epoxy resin.
US Pat. No. 10,141,169

SYSTEMS AND METHODS FOR IDENTIFYING COMPOUNDS FROM MS/MS DATA WITHOUT PRECURSOR ION INFORMATION

DH Technologies Developme...

1. A system for identifying a compound from tandem mass spectrometry product ions without using any a priori precursor ion information, comprising:a tandem mass spectrometer that analyzes a sample producing at least one measured product ion spectrum from a precursor mass-to-charge ratio range; and
a processor in communication with the tandem mass spectrometer that
(a) receives the at least one measured product ion spectrum from the tandem mass spectrometer,
(b) selects a measured product ion from the at least one measured product ion spectrum,
(c) creates a list of candidate compounds by searching a dictionary of potential compounds with a mass of the measured product ion, wherein the dictionary includes one or more predicted product ions for each of the potential compounds and wherein the dictionary is searched using a key that is a product ion mass to retrieve a list of candidate compounds that could produce the product ion mass,
(d) selects a next measured product ion from the at least one measured product ion spectrum,
(e) creates a next list of candidate compounds by searching the dictionary of potential compounds with a mass of the next measured product ion,
(f) examines all lists of candidate compounds created for candidate compounds common to all the lists, and
(g) repeats steps (d)-(f) until one candidate compound is common to all the lists and identifies the one candidate compound as the identified compound of the product ions selected.
US Pat. No. 10,137,068

METHOD FOR MAINTAINING THE COLOR OF DYED AND/OR HIGHLIGHTED KERATIN FIBRES

1. A method for the color retention of dyed keratin fibers, the method comprising:i. applying a cosmetic composition to dyed keratin fibers as a pretreatment agent for keratin,
and
ii. subjecting the keratin fibers to a dyeing and/or brightening within a period of 5 seconds to 24 hours after to step i.,
wherein the cosmetic composition has, based on its own weight, from 0.01 to 4.00% by weight of at least one alum and a pH value in the range of 2.5 to 5.
US Pat. No. 10,137,324

HALIDE-MEDIATED DEALKYLATION OF PHOSPHOTRIESTERS

Lawrence Livermore Nation...

1. A method, comprising:contacting a phosphotriester and a halogen salt in a polar solvent.
US Pat. No. 10,138,349

MASTER MIXTURE COMPOSITION INCLUDING A PEROXIDE

Arkema France, Colombes ...

1. A thermoplastic composition (I) comprising a copolymer of ethylene and of an ethylenic monomer carrying a polar functional group (a) and a peroxide (b), wherein said composition comprises, by weight,from 5 to 30% of (b);
from 70 to 95% of (a);
wherein the copolymer (a) comprises from 20 to 45% by weight of the ethylenic monomer carrying a polar functional group; and
wherein the thermoplastic composition is transparent.
US Pat. No. 10,137,069

SKIN COSMETIC COMPOSITION, ANTIBACTERIAL AGENT FOR SKIN COSMETIC, AND METHOD FOR ENHANCING ANTIBACTERIAL EFFECT OF DIOL COMPOUND

ADEKA CORPORATION, Tokyo...

1. A skin cosmetic composition comprising: a component (A) which is either hexyl glyceryl ether or both of hexyl glyceryl ether and cyclohexyl glyceryl ether, a component (B) which is either one or both of 1,2-propanediol and 1,3-propanediol, and a component (C) which is one or more compound(s) selected from the group consisting of lactic acid, hydroxyethylethylenediaminetriacetic acid, hydroxyethyliminodiacetic acid, dihydroxyethylglycine, gluconic acid, phytic acid, pentetic acid, etidronic acid, tartaric acid, salts thereof, and gluconolactone,wherein an amount of the component (B) is 1 part by mass to 30 parts by mass and an amount of the component (C) is 0.05 parts by mass to 10 parts by mass with respect to 1 part by mass of the component (A).
US Pat. No. 10,137,070

COMPOSITION INCLUDING IONONE OR SALT THEREOF AS ACTIVE INGREDIENT AND HAVING EFFECT OF ENHANCING SKIN MOISTURIZING, EXFOLIATING SKIN, IMPROVING SKIN ELASTICITY, INHIBITING ERYTHEMA, IMPROVING SKIN WRINKLES, OR ALLEVIATING SKIN PHOTOAGING

YONSEI UNIVERSITY TECHNOL...

1. A method of enhancing skin moisturizing, exfoliating skin,improving skin elasticity, inhibiting erythema, improving skin wrinkles, and/or alleviating skin photoaging, the method comprising administering or taking a composition comprising:
a skin active ingredient consisting of ionone or a pharmaceutically acceptable or consisting of ionone or a pharmaceutically acceptable salt thereof and vitamin C; and
a carrier,
wherein the composition i) increases the level of PIP(procollagen type I C-peptide), ii) increases the expression level of Collagen Type 1?1, 1?2, 3?1, or iii) decreases the expression level of MMP-1a, MMP-3, and MMP-9.
US Pat. No. 10,138,351

RUBBER COMPOSITIONS AND USES THEREOF

Bridgestone Corporation, ...

1. A rubber composition comprising:(a) 50-100 phr of at least one polymer or copolymer selected from the group consisting of synthetic conjugated diene monomer-containing polymers, synthetic conjugated diene monomer-containing copolymers, and combinations thereof;
(b) 0-50 phr of at least one polymer or copolymer selected from the group consisting of monoolefin-containing polymers, copolymers of at least one monoolefin and at least one alpha-olefin, and combinations thereof;
(c) 1-10 phr of at least one nucleating agent having formula (I)
M2(O2CR)4  (I)
where M is a transition metal selected from the group consisting of scandium, titanium, vanadium, chromium, manganese, iron, cobalt, nickel, copper, zinc, yttrium, zirconium, niobium, molybdenum, ruthenium, rhodium, palladium, silver, cadmium, hafnium, tantalum, tungsten, rhenium, osmium, iridium, platinum, gold, mercury, and iridium and R is selected from C3-C18 alkyl;
(d) 1 to 20 phr of at least one processing oil;
(e) 0-100 phr of at least one reinforcing filler and
(f) a cure package including a vulcanizing agent consisting of a sulfur-based curative,
wherein upon curing the rubber composition meets at least one of (i) or (ii), as follows:
(i) exhibits reduced wear as exhibited by having a wear index (measured at a slip percentage of 25%) that is 110% or higher, based upon a comparative rubber compound that contains no nucleating agent of formula (I) but contains additional processing oil in a phr amount equal to the amount of the at least one nucleating agent of formula (I), and
(ii) exhibits strain-induced crystallization.