US Pat. No. 10,113,290

METHOD OF INSTALLING A FOUNDATION IN THE SEA BED AND SUCH FOUNDATION

1. A sea bed foundation for an offshore facility, said sea bed foundation having a circumferential side wall substantially defining a cylinder, which cylinder is closed in one end and provided with an opening in the opposite end, thereby defining a primary chamber, said sea bed foundation is hollow, downwardly open and where said side wall defines a skirt, said primary chamber being connected to a primary pump, and wherein said sea bed foundation further comprises one or more secondary chambers, said secondary chambers being separate from the primary chamber, and being downwardly open, but otherwise closed by the sea bed foundation, where said one or more secondary chambers are connected to one or more secondary pumps wherein said primary pump is a suction pump and said secondary pump is a pressure pump, and where an over-pressure created by the one or more secondary pumps increases a resistance against penetration adjacent the one or more secondary chambers, allowing a rest of the foundation to penetrate a bottom at a normal resistance, thereby rectifying an orientation of the foundation.

US Pat. No. 10,113,287

TWO-WIRE CONTROLLING AND MONITORING SYSTEM FOR IN PARTICULAR IRRIGATION OF LOCALIZED AREAS OF SOIL

2. A two-wire controlling and monitoring system for irrigation of localized areas of soil and comprising:a water pipeline configured for providing water to said localized areas of soil;
a plurality of controllable irrigation valves, each positioned at a specific area of said localized areas of soil, each connected to said water pipeline for providing watering or non-watering of said specific area of said localized areas of soil and each having a pair of valve control inputs;
a plurality of field sensors, positioned at specific areas of said localized areas of soil, and configured for providing specific irrigation parameters, each of said field sensors having a pair of sensor outputs;
a plurality of localized irrigation control units, each comprising at least one of (a) a sensor decoder having a pair of sensor inputs connected to said pair of sensor outputs of a specific field sensor of said plurality of field sensors and configured for providing power to said plurality of field sensors and recording said specific irrigation parameters from said plurality of field sensors and (b) a line decoder having a pair of valve control outputs connected to said pair of valve control inputs of a specific controllable irrigation valve of said plurality of controllable irrigation valves for providing valve control signals to said first plurality of controllable irrigation valves, said sensor decoder and said line decoder further each having a pair of control and power supply inputs;
a controller and power supply unit having a first set of schedules of instructions according to a first communications protocol and a second set of schedules of instructions according to a second communications protocol, said controller and power supply unit having a pair of control and power outputs supplying power by applying, respectively, in accordance with each of said first communications protocol and said second communications protocol, a first alternating DC voltage signal defining a voltage maximum having a first pulse width and defining a voltage minimum having a second pulse width to one of said pair of control and power outputs, simultaneously applying a second alternating DC voltage signal similarly shaped, but of inverted polarity as compared to said first alternating DC voltage signal to another of said pair of control and power outputs and applying an alternating DC current defining a current maximum having a third pulse width and defining a current minimum having a fourth pulse width to said pair of control and power outputs, wherein the first pulse width and second pulse width of the first communications protocol are different from the first pulse width and second pulse width of the second communications protocol;
a two-wire cable interconnecting said controller and power supply unit and said plurality of localized irrigation control units and connecting said pair of control and power outputs of said controller and power supply unit to said control and power inputs of said plurality of localized irrigation control units and providing said power from said controller and power supply unit to each of said plurality of localized irrigation control units;
said controller and power supply unit being configured for transmitting a type declaration to said plurality of localized irrigation control units through said two-wire cable using said first communications protocol, said type declaration providing communication under said second communications protocol;
said controller and power supply unit being configured for transmitting said second set of schedules of instructions to said plurality of localized irrigation control units through said two-wire cable using said second communications protocol; and
said controller and power supply unit being configured for transmitting said first set of schedules of instructions to said plurality of localized irrigation control units through said two-wire cable using said first communications protocol.

US Pat. No. 10,113,284

BLADE FOR REMOVING SNOW

GILETTA S.P.A., Revello ...

1. A blade for removing snow from a road surface, the blade comprising:a shield defining a shield cavity oriented to deflect the snow;
at least one cutting edge coupled to a bottom part of said shield and adjacent to the road surface when in use, the at least one cutting edge including two walls defining an edge cavity within the at least one cutting edge, the two walls facing one another and being substantially parallel to one another; and
at least one fluid circuit comprising at least one nozzle, said at least one nozzle spreading a de-icing liquid and being positioned within the edge cavity or at least partially defined by the two walls of the edge cavity,
wherein the at least one nozzle is carried by said cutting edge to spread said de-icing liquid on the snow in an area selected from the group consisting of in front of and beneath said at least one cutting edge,
wherein said at least one cutting edge compresses snow mixed with said de-icing liquid during passage of said blade over said road surface.

US Pat. No. 10,113,283

SNOW DISCHARGE DIVERTER APPARATUS AND METHOD

1. An apparatus for snow removal diversion, comprising:a snow discharge diverter configured to change a flow of discharged snow from a snow removal vehicle connected thereto, said snow discharge diverter selectably movable between at least a snow discharging diverter position and a snow pushing diverter position, the snow discharging diverter position arranged to direct the flow of discharged snow to at least one side of a path of the snow removal vehicle, the snow pushing diverter position arranged to cause the flow of discharged snow to cumulate in a leading front side of the snow discharge diverter in a snow pushing position relative to the path of the snow removal vehicle;
a location detector antenna mounted on the snow removal vehicle at an offset distance from the snow discharge diverter;
a location detector operatively coupled to the location detector antenna to read an antenna location of the location detector antenna;
a predefined areas memory storing a list of a plurality of predefined areas for avoiding discharging snow, said list comprising a starting point location and an ending point location of each of the areas; and
a controller operatively coupled to the location detector, the predefined areas memory, and the snow discharge diverter and configured to control a position of the snow discharge diverter among the snow discharging diverter position and the snow pushing diverter position based on the antenna location and the list of the plurality of predefined areas for avoiding discharging snow, wherein the controller is constructed and arranged to:
(a) receive a first signal from the location detector, said first signal comprising updated location data of the location detector antenna;
(b) receive a second signal from the memory, said second signal comprising the location data of the plurality of predefined areas;
(c) calculate an activation distance from the location detector antenna to the start of each of the plurality of predefined areas said calculation using the antenna location and using a current snow removal vehicle speed and using the starting point location and the ending point location of the predefined areas;
(d) transmit an activation signal to the snow discharge diverter to cause the snow discharge diverter to change to the snow pushing diverter position when the antenna location is within the activation distance of any one of the predefined areas;
(e) calculate a deactivation distance from the antenna location to the ending point location of each of the plurality of predefined areas said calculation based on at least the antenna location, the current snow removal vehicle speed, and the ending point location of the predefined areas; and
(f) transmit a deactivation signal to the snow discharge diverter to cause the snow discharge diverter to change to the snow discharging diverter position when the antenna location is within the deactivation distance of the ending point location of any one of the areas;
wherein the apparatus further comprises a snow removal auger; and wherein the diverter comprises a snow discharge chute operatively coupled to the snow removal auger.

US Pat. No. 10,113,281

SNOWTHROWER IMPELLER ASSEMBLY WITH RIGID CUTTING IMPLEMENT

1. An impeller assembly for a snowthrower, comprising:a driven shaft configured to rotate about an axis;
a flexible impeller extending horizontally across substantially a complete width of the impeller assembly along the axis and configured to rotate about the axis, wherein the flexible impeller extends radially from the driven shaft to an impeller radial distance; and
a rigid cutting implement extending radially from the driven shaft to a cutting implement radial distance less than the impeller radial distance, wherein the rigid cutting implement is spaced apart from and does not contact the flexible impeller.

US Pat. No. 10,113,277

DEVICE FOR AUTOMATIC RE-STRIPING OF HORIZONTAL ROAD MARKINGS

1. A device for automatic re-striping of horizontal road markings and which can be attached to a vehicle, the device comprising:a marker unit with a linear actuator which is configured to position paint guns secured to a movable carriage over previous marking lines to be restriped, the linear actuator comprising a linear displacement transducer configured to determine coordinates of the paint guns;
an electronic control unit (14) electrically connected to the linear actuator (7), wherein the electronic control unit (14) comprises:
an electronic gyroscope (19) configured to determine an angular speed of the vehicle on curved road sections,
an electronic computation module configured to process signals received from said gyroscope and to generate signal values to be sent to a monitoring and control module,
said monitoring and control module being configured to process signals received from said linear displacement transducer, said monitoring and control module comprising drivers configured to control said linear actuator and drivers configured to control a position of solenoid valves, said solenoid valves being configured to enable and disable the paint guns, and
a near-sighting system comprising a laser scanner mounted in front of the marker unit and electrically connected to the electronic computation module, wherein the laser scanner emits a modulated beam and is configured to automatically identify coordinates of marking lines close to the paint guns, wherein the electronic computation module receives the coordinates of marking lines from the laser scanner, the electronic computation module being configured to automatically calculate a displacement between coordinates of the paint guns and coordinates of marking lines close to the paint guns, and based on said displacement, automatically send signal values to the monitoring and control module, said signal values controlling the position of said linear actuator and the position of said solenoid valves such that the paint guns automatically become positioned over corresponding marking lines,
wherein the electronic control unit is further configured to calculate and automatically offset, based on the angular speed of the vehicle, for an additional deviation of the paint guns from the coordinates of any of the marking lines when the vehicle moves on curved road sections.

US Pat. No. 10,113,276

COLD IN-PLACE RECYCLING MACHINE WITH SURGE TANK

Roadtec, Inc., Chattanoo...

1. A CIR-modified milling machine comprising:(a) a milling drum that is adapted to mill material from a roadway;
(b) a milling drum housing that contains the milling drum;
(c) an additive spray assembly that is located within the milling drum housing and adapted to dispense an asphalt additive therein;
(d) an additive flow system:
(i) which includes an inlet pipe that is adapted to be operatively connected to an external supply line;
(ii) comprising a surge tank for asphalt additive that is in fluid communication with the additive spray assembly;
(iii) comprising an additive pump for pumping asphalt additive from the surge tank to the additive spray assembly;
wherein the additive flow system includes piping and associated valves that permit operation of the additive flow system in a first mode in which the additive pump is adapted to draw asphalt additive from an external supply into the surge tank by means of the external supply line, and to pump the asphalt additive out of the surge tank to the additive spray assembly, and alternatively in a second mode in which the additive pump is adapted to draw asphalt additive from an external supply by means of the external supply line and to pump the asphalt additive out to the additive spray assembly while bypassing the surge tank.

US Pat. No. 10,113,273

INTERLOCKING HEATED PATIO STONES AND SYSTEM

1. A heated patio stone system comprising:a first patio stone interconnected to a second patio stone, wherein each patio stone comprises:
a load-supporting thermally-conductive upper layer;
an insulating lower layer;
an electrical heating cable positioned between the load-supporting thermally-conductive upper layer and the insulating lower layer;
an interconnection having a receptacle interconnected to the electrical heating cable positioned within said each patio stone; and
a bridging connector comprising:
an expandable and retractable articulated section containing an electrical wire connected to the electrical heating cable of each of the first patio stone and the second patio stone to electrically connect the first patio stone to the second patio stone:
a first basin on a first side of the expandable and retractable articulated section, closed by a first cap having a first electrical plug, the first electrical plug electrically connected to the electrical wire; and,
a second basin on a second side of the expandable and retractable articulated section, closed by a second cap having a second electrical plug, the second electrical plug electrically connected to the electrical wire;
wherein:
a length of the electrical wire from the first basin to the second basin is similar to a length of the bridging connector when the articulated section is in a fully expended state;
at least a portion of the electrical wire is contained in between the first basin and the second basin of the bridging connector when the expandable and retractable articulated section is in a fully retracted state; and,
the expandable and retractable articulated section of the bridging connector allows for limited movement of the first patio stone relative to the second patio stone.

US Pat. No. 10,113,272

FISHPLATE COMPRISING A PROTECTIVE STRIP

1. A lateral fishplate (21, 22) for isolating a railway rail (1), including a buried rail, wherein an upper face of said fishplate comprises a protective strip (26), formed of a wire mesh (32) and of a sheet (31) glued to one another.

US Pat. No. 10,113,268

INSTALLATION FOR DRYING A DAMP NON-WOVEN WEB

ANDRITZ PERFOJET SAS, Mo...

1. An installation for drying a non-woven web which comprises:a fan (6) with a delivery and an intake,
a heating oven (3) having an inlet and an outlet,
an inlet conduit (C1) which has a branch and which connects the delivery of the fan (6) with the inlet of the oven (3) and sends delivered air to the inlet of the oven,
a heat source (4) arranged in such a way that the air delivered in the inlet conduit (C1} is heated,
an outlet conduit (C2) which connects the outlet of the oven (3) with the intake of the fan (6),
a branch conduit (C3), in the branch of the inlet conduit (C1) upstream of the heat source (4), connecting the inlet conduit (C1) with an inlet of a drying device (10, 11),
a means of transport (2) which displaces a web in the drying device (10, 11) and in the oven (3), the drying device (10, 11) being upstream of the oven (3) in a direction of displacement of the web,
a conduit (C4) for extracting the air from the drying device (10, 11),
wherein the drying device comprises a diffusion chamber (10) having an outlet fitting (21) in which there is mounted a perforated sheet (24) which is mounted in a movable drawer (22) which has a handle (23) outside of the fitting (21),wherein downstream of the perforated sheet (24) is mounted in the outlet fitting (21) or in a channel which is clamped to the fitting (21) a honeycombed bundle (28), the dimension of whose cells is greater than that of the perforations of the perforated sheet (24).

US Pat. No. 10,113,267

TENSIONING APPARATUS FOR SYNTHETIC SLING MANUFACTURING APPARATUS AND METHOD

SlingMax, Inc., Aston, P...

1. A sling manufacturing apparatus for constructing a synthetic sling having a cover and a core with the core constructed of synthetic yarns, the apparatus comprising:a frame defining a longitudinal frame axis;
a yarn feeder assembly associated with the frame;
a drive roller connected to the frame, the drive roller being drivable to draw yarn from the yarn feeder assembly;
a tailstock movably mounted to the frame, the tailstock movable relative to the frame parallel to the longitudinal frame axis;
an idler roller movably mounted to the tailstock, the idler roller movable relative to the tailstock parallel to the longitudinal frame axis; and
an idler actuator comprised of a hydraulic actuator having a first cylinder, a first shaft, a second cylinder and a second shaft, the first shaft connected to a first end of the idler roller and the second shaft connected to a second end of the idler roller, the idler actuator secured to the tailstock and the idler roller, the idler actuator configured to move the idler roller from a loading position spaced at a first distance from the tailstock to a tensioned position spaced at a second distance from the tailstock, the first distance being greater than the second distance.

US Pat. No. 10,113,264

DEVICE ADAPTED TO MAINTAIN FORM AND ASSIST IN DRYING OF A GLOVE

1. A device for substantially maintaining the full form of a glove while facilitating drying of the glove, said device comprising a hand-shaped form having:a palm portion comprising a substantially planar flange having a first side and a second side; and
a plurality of finger flanges comprising: an index finger flange, a middle finger flange, a ring finger flange, and a pinky finger flange; each of said finger flanges configured to extend from said first end of said substantially planar flange of said palm portion;
a first peripheral flange configured to extend away from and be in continuous proximity to, a periphery formed by said first side of said palm portion and said plurality of finger flanges;
a second peripheral flange configured to extend away from and be in continuous proximity to, a periphery formed by said second side of said palm portion and said plurality of finger flanges;
a first transverse flange for each of said finger flanges, each configured to extend away from a first side thereof, and to be substantially centered on the finger flange;
a second transverse flange for each of said finger flanges, each configure to extend away from a first side thereof, and to be substantially centered on the finger flange; and
a thumb portion.

US Pat. No. 10,113,263

LAUNDRY TREATING APPLIANCE WITH IMAGING CONTROL

Whirlpool Corporation, B...

1. A laundry treating appliance for treating laundry according to an automatic treating cycle of operation, comprising:a laundry treating chamber receiving laundry for treatment;
at least one component operable to implement at least part of the automatic treating cycle of operation;
an imaging device mounted to the laundry treating appliance and having a sensor operably coupled with at least a portion of the laundry treating chamber during execution of the automatic treating cycle of operation and outputting data representative of at least a portion of the laundry in the laundry treating chamber;
an indicator configured to output a signal; and
a controller receiving the data and operably coupled to the indicator, the controller comprising analysis software that is configured to determine a motion condition of the laundry based on the data and the controller configured to determine a condition of concern of the laundry based on the data and to activate the indicator to emit a signal based on the determined condition to notify a user of the determined condition of concern.

US Pat. No. 10,113,262

DRYER APPLIANCES AND METHODS FOR DIAGNOSING RESTRICTIONS IN DRYER APPLIANCES

Haier US Appliance Soluti...

1. A method for diagnosing a restriction in a dryer appliance, the method comprising:obtaining a plurality of temperature readings at a controller of the dryer appliance during each operation of the dryer appliance by intermittently measuring a temperature of inlet air to the dryer appliance from a temperature sensor mounted within a cabinet of the dryer appliance;
obtaining a heater status for a heater of the dryer appliance at the controller during each measurement of the temperature;
estimating an effective opening size equal to or smaller in relation to an actual opening size of an outlet assembly in the dryer appliance at the controller during each operation of the dryer appliance based on the temperature and heater status for each of the plurality of temperature readings, the estimating comprising
calculating a heater contribution rate for temperature and a decay rate for temperature for the plurality of temperature readings at the controller utilizing the temperature and heater status for each of the plurality of temperature readings, and
utilizing at least one of the heater contribution rate for temperature and the decay rate for temperature to estimate the effective opening size; and
transmitting a restriction signal from the controller when the effective opening size is less than a predetermined minimum size threshold,
wherein the effective opening size is correlated to the at least one of the heater contribution rate for temperature or the decay rate for temperature,
wherein the heater contribution rate for temperature includes a rate of temperature increase at an active status of the heater, and
wherein the decay rate for temperature includes a rate of temperature decrease at an inactive status of the heater.

US Pat. No. 10,113,261

FABRIC TREATING APPARATUS

LG Electronics Inc., Seo...

1. A fabric treating apparatus comprising:a casing that comprises:
a treating chamber that is configured to receive clothes; and
a machinery room that is located below the treating chamber;
a base that is located at a bottom of the machinery room;
a heat pump module that is configured to condition air supplied to the treating chamber;
at least one supporter (a) that includes a shelf (i) that is supported by legs that are fixed to the base and (ii) that supports the heat pump module and that defines a space (i) between the base and the heat pump module and (ii) below the shelf and (b) that includes a first supporter fixing tab that includes a surface that faces the base and that is located at a lower part of at least one of the legs;
a steam generating module that is located in the space and that is configured to generate steam and supply steam to the treating chamber; and
a controller that is configured to control at least one of the heat pump module or the steam generating module, the controller being located in the space and below the steam generating module,
wherein the base includes a first supporter fixing part that includes a first supporter fastening hole that is configured to receive the first supporter fixing tab.

US Pat. No. 10,113,260

LAUNDRY TREATING APPLIANCE

Whirlpool Corporation, B...

1. A laundry treating appliance configured to implement a cycle of operation to treat a load of laundry, comprising:a basket defining a treating chamber and rotatable about an axis of rotation;
a motor having a rotor and a stator;
a shifter within an interior diameter of the stator and having an energizable clutch coil at least partially enveloped in a magnetically permeable housing and a magnetically permeable slidable drive mechanism radially spaced from the housing and configured to selectively couple the basket with the rotor; and
a concentric magnetically permeable ring located on the rotor, radially spaced and axially aligned with a portion of the magnetically permeable housing, and radially aligned and axially spaced from the slidable drive mechanism.

US Pat. No. 10,113,259

FLANGE STRUCTURE AT BOTTOM OF INNER TUB OF WASHING MACHINE AND A WASHING MACHINE

QINGDAO HAIER WASHING MAC...

1. A flange structure for use at a bottom of an inner tub of a washing machine, comprisinga shaft joint portion located at a center of the flange,
an annular mounting portion configured to be fixedly connected with the bottom of the inner tub of the washing machine and located at an outer periphery of the shaft joint portion,
a plurality of connecting portions provided between the mounting portion and the shaft joint portion, each connecting portion including a main rib extending from the mounting portion to the shaft joint portion, and
a plurality of transverse ribs arranged on both sides of the main rib in an extending direction of the main rib respectively in turn,
wherein the connecting portions descend from the main rib towards both sides in an extending direction of the transverse ribs,
a V-shaped recess is formed between two adjacent connecting portions, and a V-shaped recess bottom end is a breach of the flange formed by a distance between the transverse ribs of the two main ribs for water flow,
and wherein a filter portion is formed in a region between the mounting portion and the shaft joint portion by the plurality of connecting portions.

US Pat. No. 10,113,258

LAUNDRY TREATMENT APPARATUS

LG Electronics Inc., Seo...

1. A laundry treatment apparatus comprising:a housing;
a tub that is located inside the housing and that is configured to receive water;
a drum that is configured to rotate, that is located inside the tub, and that is configured to receive laundry; and
three or more tub support units that are each configured to connect the tub and the housing and that includes:
a first support member that is located at the housing;
a second support member that is located at the tub; and
a connector that is configured to connect the first support member and the second support member,
wherein the first support member of at least one of the three or more tub support units includes a first bracket that is detachably coupled to the housing and that is located adjacent to a first side of the tub, and
wherein the first support member of one or more remaining of the three or more tub support units includes a second bracket that is integrated with the housing and that is located adjacent to a second side of the tub that is opposite the first side of the tub.

US Pat. No. 10,113,257

MULTI-NEEDLE BAR MODULE FOR SEWING MACHINES

NINGBO SUPREME ELECTRONIC...

1. A multi-needle bar module for sewing machines, comprising a mounting plate adapted to a front end of a sewing machine head, characterized in that the mounting plate is equipped in a sliding manner, via a bracket, with a needle bar mounting frame on which at least two needle bars are distributed at intervals, the needle bars being in axial sliding fit with the needle bar mounting frame;the mounting plate is provided with a U-shaped first horizontal guideway and a U-shaped second horizontal guideway disposed at intervals and spaced apart, and a needle bar driving block with a neck is disposed between the first horizontal guideway and the second horizontal guideway; the needle bars are provided with guide members that can be clamped into the first horizontal guideway and the second horizontal guideway; the needle bar mounting frame clamps, by sliding horizontally, the guide of any one of the needle bars individually into the neck;
wherein the U-shaped first horizontal guideway and the U-shaped second horizontal guideway are positioned in a same plane such that sectional areas of the first horizontal guideway and the second horizontal guideway along the same plane are respectively in a U-shape, two free ends of two parallel arms of the U-shaped first horizontal guideway point to and are aligned with two free ends of two parallel arms of the U-shaped second horizontal guideway, respectively; a cuboid-shaped opening between the two parallel arms of the U-shaped first horizontal guideway and a cuboid-shaped opening between the two parallel arms of the second horizontal guideway oppose and are aligned with each other, the needle bar driving block with the neck is vertical to the same plane of the U-shaped first and second horizontal guideways; and
the two free ends of the two parallel arms of the U-shaped first horizontal guideway are not connected with the two free ends of the two parallel arms of the U-shaped second horizontal guideway.

US Pat. No. 10,113,256

EMBROIDERY CONVERSION DEVICE FOR EMBROIDERY SEWING MACHINE, EMBROIDERY CONVERSION METHOD FOR EMBROIDERY SEWING MACHINE, AND RECORDING MEDIUM STORING EMBROIDERY CONVERSION PROGRAM FOR EMBROIDERY SEWING MACHINE

Janome Sewing Machine Co....

1. An embroidery conversion device for an embroidery sewing machine having embroidery monotone color display data and embroidery data for each of embroidery areas, and capable of performing conversion for forming embroidery in a given embroidery color by selecting embroidery areas that are displayed to specify a color for the areas, and by having the color specification for the embroidery areas and embroidery data for the selected embroidery areas be recorded, the device comprising:a base-color setting unit that sets a base color used in monotone embroidery in which embroidery is formed in shades of one color entirely over the embroidery areas;
a gradation-data generating unit that generates gradation data expressing shading for monotone embroidery, based on an embroidery color specified for each of the embroidery areas;
a gradation shade-number setting unit that allows a user to set a number of shades in gradation for monotone embroidery to be used in execution of monotone embroidery, within a limit determined based on a multicolor embroidery pattern to which a plurality of color threads are assigned;
a gradation-data converting unit that converts the gradation data generated by the gradation-data generating unit into working gradation data of the number of shades in gradation set by the gradation shade-number setting unit, and to set the working gradation data as the embroidery monotone color display data;
a recording unit that collectively records the embroidery monotone color display data specified for each of the embroidery areas and embroidery stitch data; and
a control unit that controls the embroidery sewing machine to perform an embroidery operation of a monotone color image with gradation as an entire image converted from a multicolor image, based on the embroidery monotone color display data.

US Pat. No. 10,113,255

NON-WOVENS WITH HIGH INTERFACIAL PORE SIZE AND METHOD OF MAKING SAME

1. A container of wipes comprising:a housing; and
a plurality of wipes at least partially overlapping one another and contained at least partially within the housing;
wherein a surface of each of the plurality of wipes includes a continuous raised portion and a plurality of discrete recessed portions;
the continuous raised portion of a first wipe being configured to prevent its continuous raised portion from nesting within the plurality of recessed portions of an adjacent second wipe; andwherein an average pore-size of the interface between the first and second wipes is greater than 180 microns in radius.

US Pat. No. 10,113,254

DISPERSIBLE MOIST WIPE

KIMBERLY-CLARK WORLDWIDE,...

1. A dispersible moist wipe comprising a nonwoven tissue web having regenerated fibers in an amount of about 10 to about 30 percent by weight and natural fibers in an amount of about 70 to about 90 percent by weight, wherein the regenerated fibers and the natural fibers are hydroentangled using an energy within a range between about 0.12 kw-hr/kg and about 0.9 kw-hr/kg such that the web has a geometric mean tensile strength of at least 150 grams per inch and a slosh-box break-up time of less than 155 minutes, the nonwoven tissue web being free of a binder and having a formation value of at least 12, wherein the nonwoven tissue web has at least one ribbon-like structure extending along the nonwoven tissue web, and at least one hole in the nonwoven tissue web positioned adjacent the at least one ribbon-like structure, the at least one ribbon-like structure defining an area of higher entanglement of the regenerated fibers and the natural fibers than in other areas of the nonwoven tissue web.

US Pat. No. 10,113,253

METHOD AND APPARATUS FOR FABRICATING SUSCEPTOR COIL ASSEMBLIES

The Boeing Company, Chic...

1. An apparatus for fabricating a susceptor coil assembly, the apparatus comprising:a tensioning section;
a feeding section configured for feeding a conductor wire toward the tensioning section, the tensioning section being configured for maintaining a desired tension of the conductor wire; and
a coiling section configured for winding a susceptor wire around an outer surface of the conductor wire so as to fabricate a susceptor coil assembly as the conductor wire moves from the feeding section toward the tensioning section, the coiling section comprising a winder head comprising:
a first wire inlet configured for receiving the conductor wire from the feeding section; and
a second wire inlet that extends radially from the first wire inlet and is configured for radially receiving the susceptor wire as the coiling section winds the susceptor wire and for receiving the conductor wire as the conductor wire moves toward the tensioning section.

US Pat. No. 10,113,252

SYSTEMS AND METHODS FOR IMPROVING AND CONTROLLING YARN TEXTURE

COLUMBIA INSURANCE COMPAN...

1. A yarn system for controlling and improving the consistency of a texture of yarn, the yarn system comprising:a texturing apparatus configured for imparting a desired texture in the yarn, wherein the texturing apparatus comprises:
a stuffer box defining an internal chamber having an inlet end and an outlet end through which the yarn passes,
a climate chamber positioned downstream of the stuffer box, wherein the climate chamber sets the desired texture in the yarn, and
a source of compressed gas in fluid communication with the internal chamber of the stuffer box, wherein the compressed gas is configured to move the yarn from the inlet end toward the outlet end of the internal chamber of the stuffer box;
a plurality of rollers for moving the yarn through the yarn system, wherein at least one roller of the plurality of rollers is coupled to and driven by at least one roller motor, wherein the plurality of rollers comprise:
at least one delivery roller driven by a delivery motor and configured to deliver the yarn to the inlet end of the internal chamber of the stuffer box, and
at least one overfeed roller driven by an overfeed motor configured to deliver the yarn to the at least one delivery roller;
a plurality of sensors, each sensor of the plurality of sensors configured to sense an operating parameter of the yarn system, the plurality of sensors comprising:
at least one transport air pressure sensor configured to sense the pressure of the compressed gas supplied by the source of compressed gas in fluid communication with the internal chamber, wherein the at least one transport air pressure sensor is coupled to a processor,
at least one vacuum fan positioned downstream of the climate chamber and configured to cool the yarn after the yarn exits the climate chamber, and
at least one yarn temperature sensor configured to sense the temperature of the yarn after the yarn is cooled by the at least one vacuum fan, wherein the at least one yarn temperature sensor is coupled to the processor,
wherein the processor is configured to stop operation of the yarn system when the at least one transport air pressure sensor senses a pressure outside of a transport air pressure tolerance for a first amount of time; and
a plurality of additional sensors coupled to the processor and configured to sense additional operating parameters of the yarn system, wherein the processor is configured to stop operation of the yarn system when an additional sensor of the plurality of additional sensors senses an operating parameter outside of a tolerance for the additional sensor for a second amount of time,
wherein the at least one overfeed motor delivers the yarn to the at least one delivery roller, and wherein the at least one delivery roller delivers the yarn to the inlet end of the internal chamber of the stuffer box.

US Pat. No. 10,113,251

SLIVER GUIDE FOR A DRAWING FRAME, AND A DRAWING FRAME WITH THE SILVER GUIDE

Rieter Ingolstadt GmbH, ...

1. A sliver guide for guiding a multiple number of fiber slivers in an entrance area of a draw frame, comprising:a first guide section disposed to guide a first group of fiber slivers;
a second guide section disposed to separately guide a second group of fiber slivers;
in a side view of the sliver guide, the first guide section and the second guide section spaced apart from each other in one or both of a vertical direction or a transport direction of the fiber slivers through the sliver guide;
a third guide section spaced apart from the first guide section and the second guide section in the side view in one or both of the vertical direction or the transport direction of the fiber slivers through the sliver guide;
first lateral guide elements configured with at least one of the guide sections, wherein a lateral distance between the first lateral guide elements is adjustable.

US Pat. No. 10,113,250

MODIFICATION OF CONTINUOUS CARBON FIBERS DURING MANUFACTURING FOR COMPOSITES HAVING ENHANCED MOLDABILITY

GM GLOBAL TECHNOLOGY OPER...

1. A method of manufacturing a continuous carbon fiber for use in composites having enhanced moldability, the method comprising:introducing a continuous precursor fiber comprising a polymer material into a heated environment; and
directing laser energy towards a plurality of discrete target regions of the continuous precursor fiber while in the heated environment to create a continuous carbon fiber having a plurality of discrete weak regions corresponding to the plurality of discrete target regions.

US Pat. No. 10,113,248

GROUP III NITRIDE CRYSTAL SUBSTRATE, EPILAYER-CONTAINING GROUP III NITRIDE CRYSTAL SUBSTRATE, SEMICONDUCTOR DEVICE AND METHOD OF MANUFACTURING THE SAME

Sumitomo Electric Industr...

1. A wafer comprising a semiconductor device structure including a group III nitride crystal substrate and at least one semiconductor layer provided by epitaxial growth on a main surface of said crystal substrate, wherein,a plane spacing of arbitrary specific parallel crystal lattice planes of said crystal substrate being obtained from X-ray diffraction measurement performed with variation of X-ray penetration depth from a main surface of said crystal substrate while X-ray diffraction conditions of said specific parallel crystal lattice planes of said crystal substrate are satisfied,
a uniform distortion at a surface layer of said crystal substrate represented by a value of |d1?d2|/d2 is equal to or lower than 1.7×10?3 where d1 indicates a plane spacing at said X-ray penetration depth of 0.3 ?m and d2 indicates a plane spacing at said X-ray penetration depth of 5 ?m, and wherein
a plane orientation of said main surface has an inclination angle equal to or greater than ?10° and equal to or smaller than 10° in a [0001] direction with respect to any of {10-10}, {11-20} and {21-30} planes of crystal substrate,
wherein said semiconductor layer includes a light emitting layer emitting light having a peak wavelength equal to or more than 500 nm and equal to or less than 550 nm.

US Pat. No. 10,113,246

SUBSTRATE HOLDER, PLATING APPARATUS, AND PLATING METHOD

EBARA CORPORATION, Tokyo...

1. A substrate holder comprising:inner contacts to be brought into contact with a periphery of a substrate for passing an electric current to the substrate;
outer contacts each having elasticity, the outer contacts having contact surfaces, respectively, to be brought into contact with a feeding terminal coupled to a power source, the outer contacts being coupled to the inner contacts, respectively; and
a conductive block arranged in back of the contact surfaces having a first position not in contact with the outer contacts,
wherein the outer contacts are deformable until the outer contacts are brought into contact with the conductive block in a second position when the contact surfaces are pressed against the feeding terminal.

US Pat. No. 10,113,245

ELECTROPLATING CONTACT RING WITH RADIALLY OFFSET CONTACT FINGERS

Applied Materials, Inc., ...

1. An electroprocessing apparatus comprising:a head;
a rotor in the head;
an annular contact ring attachable onto the rotor;
a frame including a vessel, with the head movable to position the annular contact ring in the vessel and out of the vessel;
a plurality of first contact fingers aligned on the annular contact ring, with each of the first contact fingers having a first length;
a plurality of second contact fingers aligned on the annular contact ring, with each of the second contact fingers having a second length less than the first length;
wherein each of the plurality of first and second contact fingers are aligned on a radius of the annular contact ring and extend radially inwardly from the annular contact ring; and
wherein the plurality of first and second contact fingers are arranged in a plurality of clusters disposed substantially around an entire diameter of the annular contact ring, with each cluster including one first contact finger and one second contact finger.

US Pat. No. 10,113,243

MANUFACTURING METHOD OF CASING OF ELECTRONIC DEVICE

HTC Corporation, Taoyuan...

1. A manufacturing method of a casing of an electronic device, comprising:forming a shell by an injection molding technology, and the shell comprising a button portion; and
electroplating a sensing assembly on an inner surface of the shell, the sensing assembly comprising a first conductive line and two first contacts, wherein the first conductive line forms a strain sensing pattern on the button portion, and the two first contacts connect to two ends of the first conductive line, respectively; and
forming a protective layer on the inner surface of the shell, and the protective layer covers the first conductive line and exposes the two first contacts.

US Pat. No. 10,113,242

SYSTEMS AND METHODS FOR PRODUCING METAL CLUSTERS; FUNCTIONALIZED SURFACES; AND DROPLETS INCLUDING SOLVATED METAL IONS

Purdue Research Foundatio...

1. A method for producing metal cluster ions, the method comprising:applying voltage and heat to a metal salt at atmospheric pressure to thereby ionize the metal salt and produce metal cluster ions; and
directing the metal cluster ions to a target.

US Pat. No. 10,113,241

CONTROL BOARD FOR CONTROLLING CHANNEL SEQUENCING OF POSITIVE AND NEGATIVE DC VOLTAGE AND CURRENT

1. A system for controlling sequencing of positive and negative DC voltage and current to release hydrogen gas from water consisting of:a power cable for delivery of power;
one or more stainless steel plate or groups of stainless steel plates consisting of a center hole, to accommodate the power cable for delivery power to the stainless steel plate, surrounded by a continuous flat surface where the flat surface has four equal straight sides forming a square;
a controller board consisting of:
a processing circuit;
a memory device coupled to the processing circuit, the memory device programmed by the processing circuit to deliver one or more sequences to the one or more stainless steel plates or groups of stainless steel plates, the one or more sequences defining the order in which power is delivered to the one or more devices or groups of devices;
a first plurality of two position terminal blocks connected to pairs of positive drive outputs of a first group of transistors for providing a power connection to the one or more devices or groups of devices;
a second plurality of two position terminal blocks connected to pairs of negative drive outputs of a second group of transistors for providing a ground connection to the one or more devices or groups of devices;
a manual run/program switch assembly, in communication with the processing circuit, operable between a run position and a program position, wherein the run position causes the controller board to follow a pre-programmed sequence and wherein the program position allows for the programming of a new sequence;
a display, connected to the processing circuit, for displaying the current sequence;
a first plurality of visual indicators connected to the negative drive outputs for identifying which negative output channels is currently activated;
a second plurality of visual indicators connected to the positive drive outputs for identifying which positive output channel is currently activated;
a first plurality of electric dip switches in communication with the processing circuit for programming which of the positive drive outputs to turn On at each step in the sequence, the number of the first plurality of electric dip switches corresponds to the total number of positive drive outputs;
a second plurality electric dip switches in communication with the processing circuit for programming which of the negative drive outputs to turn On at each step in the sequence, the number of the second plurality of electric switches corresponds to the total number of negative drive outputs;
a save button, an up button, a down button and a select button in communication with the processing circuit for programming and saving and the sequences of the positive drive outputs and the negative drive outputs as defined by the first plurality of electronic dip switches and the second plurality of electronic dip switches; and
wherein the one or more stainless steel plates or groups of stainless steel plates are submerged in the water.

US Pat. No. 10,113,238

GOLD PLATE COATED STAINLESS MATERIAL AND METHOD OF PRODUCING GOLD PLATE COATED STAINLESS MATERIAL

TOYO KOHAN CO., LTD., To...

1. A gold plate coated stainless material comprising:a stainless steel sheet coated with a gold plated layer which is deposited directly on a passivation film present on a surface of the stainless steel sheet, wherein
the passivation film has a surface composition having a Cr/O value comprised within a range from 0.05 to 0.2 and a Cr/Fe value comprised within a range from 0.5 to 0.8, the Cr/O value and the Cr/Fe value obtained by Auger electron spectroscopy analysis.

US Pat. No. 10,113,237

MANUFACTURING METHOD OF ROTATING MACHINE, PLATING METHOD OF ROTATING MACHINE, AND ROTATING MACHINE

MITSUBISHI HEAVY INDUSTRI...

1. A manufacturing method of a rotating machine comprising:a casing forming process of forming a casing of the rotating machine that has multiple openings and suctions and discharges a fluid;
a surface activating process of supplying a pretreatment liquid into the casing through the openings, then discharging the pretreatment liquid from the casing through the openings, and activating an inner surface of the casing after the casing forming process;
a preheating process of supplying a preheating liquid into the casing through the openings, then discharging the preheating liquid from the casing through the openings, and preheating the casing after the surface activating process;
a plating process of performing supply and discharge of a plating liquid into and from the casing through the openings to circulate the plating liquid and plating the inner surface of the casing after the preheating process; and
an assembling process of providing a rotating body that is rotatable relative to the casing such that the rotating body is covered from an outer circumference side by the casing plated in the plating process,
wherein, in the surface activating process, the preheating process, and the plating process, each of the pretreatment liquid, the preheating liquid, and the plating liquid corresponding to each process is supplied into the inner surface of the casing in a range above a liquid level of each of the pretreatment liquid, the preheating liquid, and the plating liquid corresponding to each process in the casing by a treatment liquid auxiliary supply device separately from each of the pretreatment liquid, the preheating liquid, and the plating liquid corresponding to each process which is supplied from the openings of the casing, and
the treatment liquid auxiliary supply device is vertically moved according to a vertical change of the liquid level of each of the pretreatment liquid, the preheating liquid, and the plating liquid corresponding to each process in the casing.

US Pat. No. 10,113,236

BATCH CURING CHAMBER WITH GAS DISTRIBUTION AND INDIVIDUAL PUMPING

APPLIED MATERIALS, INC., ...

1. A batch substrate processing chamber, comprising:multiple sub-processing regions that are each configured to receive a substrate from an atmospheric robot and to perform a curing process on the substrate received from the atmospheric robot;
a loading opening formed in a wall of the batch processing chamber;
a first door disposed over the loading opening; and
a cover plate disposed over the loading opening comprising multiple slotted openings, wherein
the first door is disposed over all of the multiple slotted openings,
the first door is configured to seal the loading opening with a sealing surface that encompasses the multiple slotted openings,
each of the slotted openings are configured to allow at least one atmospheric robot to extend an arm from a position outside of the batch processing chamber to one of the multiple sub-processing regions, and
each of the multiple slotted openings are configured to reduce the free area of the loading opening when the loading opening is open.

US Pat. No. 10,113,235

SOURCE GAS SUPPLY UNIT, FILM FORMING APPARATUS AND SOURCE GAS SUPPLY METHOD

Tokyo Electron Limited, ...

1. A source gas supply method to a film forming unit for forming a film on a substrate, comprising:generating a source gas containing vaporized raw material by supplying a carrier gas to a raw material tank accommodating a solid or liquid raw material at a plurality of carrier gas flow rate set values using a first flow path;
switching a destination of the source gas to the first flow path so that the source gas bypasses the film forming unit to discharge the source gas;
measuring flow rates of the source gas at the carrier gas flow rate set values, respectively while the source gas bypasses the film forming unit using the first flow path;
storing in a storage unit a vaporization flow rate table maintaining correspondence between the carrier gas flow rate set values and vaporization flow rates which are flow rates of the vaporized raw material contained in the source gas and obtained from the difference between the measured flow rates of the source gas and the carrier gas flow rate set values;
calculating a corresponding carrier gas flow rate set value corresponding to a specified vaporization flow rate set value required by a user for forming the film on the substrate by using the vaporization flow rate table; and
generating a corresponding source gas by supplying a corresponding carrier gas to the raw material tank at the calculated corresponding carrier gas flow rate set value while supplying the generated corresponding source gas to the film forming unit using a second flow path, wherein the first flow path and the second flow path are different, and wherein the corresponding source gas flows to the film forming unit using the second flow path when forming the film on the substrate.

US Pat. No. 10,113,234

UV ASSISTED SILYLATION FOR POROUS LOW-K FILM SEALING

APPLIED MATERIALS, INC., ...

1. A method for forming a sealing layer, comprising:delivering UV energy to a substrate disposed in a process chamber, wherein a porous low-k dielectric film is disposed on the substrate;
forming an intermediate sealing layer, wherein forming the intermediate sealing layer sequentially comprises:
flowing a first precursor compound into the process chamber while delivering UV energy to the porous low-k dielectric film disposed on the substrate, wherein the first precursor compound comprises acetoxytrimethylsilane or dimethylaminotrimethylsilane;
stopping the flow of the first precursor compound;
flowing a second precursor compound into the process chamber while delivering UV energy to the porous low-k dielectric film disposed on the substrate, wherein the second precursor compound comprises diacetoxydimethylsilane or bis(dimethylamino)dimethylsilane; and
exposing the substrate to UV energy after flowing the second precursor compound to cure the intermediate sealing layer; and
repeating the forming of the intermediate sealing layer to form additional intermediate sealing layers.

US Pat. No. 10,113,233

MULTI-ZONE TEMPERATURE CONTROL FOR SEMICONDUCTOR WAFER

Taiwan Semiconductor Manu...

1. An apparatus, comprising: a controller programmed to receive a plurality of measurements of a critical dimension (CD) at respective locations in a circuit pattern etched from a film comprising a film material on a first semiconductor substrate; and a single wafer chamber for forming a second film of the film material on a second semiconductor substrate, wherein a first film material is deposited on the first semiconductor substrate by the single wafer chamber, the single wafer chamber being responsive to a control signal from the controller to adjust a thickness of the second film at one or more of the respective locations based on the plurality of measurements of the CD, wherein the single wafer chamber has a platen that supports the second semiconductor substrate, and wherein the single wafer chamber includes a plurality of heating elements, wherein each of the plurality of heating elements is moveable with respect to the platen; and a plurality of driver units, wherein a single driver unit is coupled to one respective heating element to independently actuate said one respective heating element in a plane parallel to a wafer-engaging surface of the platen, wherein each single driver unit is configured to move one respective heating element in two orthogonal directions in the plane parallel to the wafer-engaging surface of the platen, and wherein each single driver unit is configured to provide independent adjustments to positions of one respective heating element.

US Pat. No. 10,113,231

PROCESS KIT INCLUDING FLOW ISOLATOR RING

APPLIED MATERIALS, INC., ...

1. A process chamber comprising:a sidewall;
a substrate support having an outer ledge;
a gas inlet beneath the substrate support;
a first liner having an annular inner surface separated from the outer ledge of the substrate support by a first gap, the first liner further having an outer angled surface; and
a flow isolator ring having an inner bottom surface configured to be disposed on the outer ledge of the substrate support when the substrate support is in a raised position and an outer bottom surface extending outwardly relative to the inner bottom surface, the outer bottom surface overlying the first gap, wherein the flow isolator ring further comprises:
a top surface located inwardly relative to an outer edge of the outer bottom surface; and
an outer angled surface between the top surface and the outer bottom surface, the outer angled surface oriented inwardly towards the top surface, wherein
the outer bottom surface of the flow isolator ring is configured to be disposed on the first liner when the substrate support is in a lowered position, and
the outer angled surface of the flow isolator ring and the outer angled surface of the first liner are configured to be collinear when the substrate support is in the lowered position.

US Pat. No. 10,113,229

TECHNIQUES FOR CONTROLLING ION/NEUTRAL RATIO OF A PLASMA SOURCE

Varian Semiconductor Equi...

20. A method for increasing a ratio of reactive ions to a neutral species, the method comprising:providing a processing apparatus comprising:
a plasma source chamber including a first gas inlet delivering a first gas; and
a deposition chamber coupled to the plasma source chamber, the deposition chamber including a second gas inlet and a third gas inlet delivering a point of use (POU) gas to an area proximate a substrate disposed within the deposition chamber, wherein the POU gas is different than the first gas, wherein the POU gas is delivered from the second gas inlet and from the third inlet on opposite sides of the first gas, and wherein the POU gas is delivered from the second gas inlet and from the third gas inlet in a same direction orthogonal to the substrate;
increasing a pressure within the deposition chamber in an area proximate the substrate to increase an amount of reactive ions present for impacting the substrate when an ion beam is delivered to the substrate, wherein the pressure is increased by optimizing each of the following: a gas flow rate of a first inlet of the plasma source chamber, a gas flow rate of at least one gas inlet of the first and second inlets of the deposition chamber, a distance between the substrate and the plasma source chamber, a pump speed of a deposition chamber pump fluidly connected with the deposition chamber, and a pump speed of a plasma source chamber pump fluidly connected with the plasma source chamber; and
generating the ion beam for delivery to the substrate, wherein the increase in pressure in the area proximate the substrate increases a ratio of reactive ions to neutral species impacting the substrate when the ion beam is delivered to the substrate, and wherein the ion beam is delivered to the substrate at a non-perpendicular angle relative to the substrate.

US Pat. No. 10,113,228

METHOD FOR CONTROLLING SEMICONDUCTOR DEPOSITION OPERATION

TAIWAN SEMICONDUCTOR MANU...

1. A method for controlling a semiconductor deposition operation, comprising:identify a normalized full service target lifetime according to off-line measurements;
identifying a first target lifetime by a controller in a physical vapor deposition (PVD) system, the first target lifetime being identified at about 0.43 of the normalized full service target lifetime;
inputting the first target lifetime into a processor;
outputting, by the processor, a reactive gas flow rate according to a segment corresponding to the first target lifetime of a compensation curve, the compensation curve being predetermined and stored in a memory device of the controller; and
tuning the reactive gas flow rate in the PVD system so as to achieve an atomic ratio of target material and reactive gas of a deposited layer close to unity at the first target lifetime.

US Pat. No. 10,113,227

CRUCIBLE

BOE TECHNOLOGY GROUP CO.,...

1. A crucible, comprising a main cavity, wherein the crucible further comprises a plurality of sub-cavities which are arranged in the main cavity and are used for containing solid evaporation material, each of the sub-cavities being provided with an opening,wherein between any two adjacent sub-cavities, a conduit for mutual communication between said two adjacent sub-cavities is arranged and a through hole is formed on a side wall of each of the two adjacent sub-cavities at a position that connects the through hole with the conduit,
wherein the through hole penetrates a side of each of the two adjacent sub-cavities at a position below the respective opening,
wherein the conduit is detachably fixed to the side wall of each of the two adjacent sub-cavities by a connecting device,
wherein the conduit is made of a same material as the main cavity and the sub-cavities, and
wherein a switch shutter is provided on the side wall of each of the two adjacent sub-cavities and aligned with the through hole formed on each of the two adjacent sub-cavities.

US Pat. No. 10,113,226

SPALLATION-RESISTANT THERMAL BARRIER COATING

United Technologies Corpo...

1. A coated article comprising:a metallic substrate (22);
a bondcoat (30) comprising:
a first layer (32); and
a second layer (34), the first layer being between the second layer and the metallic substrate and having a lower Cr content than the second layer; and
a thermal barrier coating (TBC) (28),wherein by weight percent:the bondcoat second layer comprises 20-40 Cr, up to 30 Co, 5-13 Al, up to 2 Y, up to 2 Si, and up to 2 Hf, balance Ni with less than 2.0 individually and less than 5.0 aggregate other elements, if any; and
the bondcoat first layer comprises 1.0-30 Cr, up to 30 Co, 3-35 Al, 0.1-2 Y, 0.1-2 Hf, 0.1-7 Si, up to 8 Ta, up to 8 W, up to 2 Mo, and up to 2 Zr, balance Ni with less than 2.0 individually and less than 5.0 aggregate other elements, if any.

US Pat. No. 10,113,225

MASKANT FOR USE IN ALUMINIZING A TURBINE COMPONENT

Howmet Corporation, Whit...

1. A mask for preventing aluminizing of a region of a component made of a superalloy, comprising a mixture of chromium-containing powder, nickel-containing powder and refractory powder wherein the chromium-containing powder comprises metallic chromium powder or chromium-containing metal alloy powder, the chromium-containing powder being present in the mixture in an amount greater than about 10 weight % effective (a) to supply chromium to form a chromium-enriched surface on the superalloy component beneath the mask during aluminizing of an unmasked region or (b) to supply chromium to a pre-existing chromium-enriched chromized surface on the superalloy component beneath the mask to retain the chromium-enriched chromized surface during aluminizing of an unmasked region.

US Pat. No. 10,113,224

FRICTION ADJUSTMENT INTERFACE BETWEEN TWO PARTS MADE OF NICKEL OR NICKEL OR COBALT-CHROMIUM ALLOY THAT ARE IN RELATIVE MOTION AGAINST ONE ANOTHER AT HIGH TEMPERATURE

Airbus Operations (S.A.S....

1. An adjustment interface inserted between a first part made of nickel, a nickel alloy or a cobalt-chromium alloy that is in relative motion with a second part made of nickel, a nickel alloy or a cobalt-chromium alloy, wherein the adjustment interface comprises two adjustment layers comprising:a first adjustment layer deposited on the first part of the two parts and having a composition that makes it possible, with the friction with the second part, to create a glaze-type layer;
a second adjustment layer deposited on the second part for cooperation with the first adjustment layer by acting as a catalyst for an oxide formed by friction with the first adjustment layer.

US Pat. No. 10,113,223

HOT-DIP GALVANIZED STEEL SHEET

1. A hot-dip galvanized steel sheet comprising:a steel sheet; and
a hot-dip galvanized layer formed on at least one surface of the steel sheet,
the steel sheet includes:
a chemical composition comprising, % by mass:
C: 0.040% to 0.280%,
Si: 0.05% to 2.00%,
Mn: 0.50% to 3.50%,
P: 0.0001% to 0.1000%,
S: 0.0001% to 0.0100%,
Al: 0.001% to 1.500%,
N: 0.0001% to 0.0100%,
O: 0.0001% to 0.0100%, and
a remainder of Fe and impurities;
wherein in a range of ? thickness to ? thickness centered at a position of ¼ thickness from the surface of the steel sheet, by volume fraction, said steel sheet includes:
0 to 50% of a ferrite phase,
a total of 50% or more of a hard structure comprising one or more of a bainite structure, a bainitic ferrite phase, a fresh martensite phase and a tempered martensite phase,
a residual austenite phase is 0 to 8%, and
a total of a pearlite phase and a coarse cementite phase is 0 to 8%,
wherein in a surface layer range of 20 ?m depth in a steel sheet direction from an interface between the hot-dip galvanized layer and a base steel, said steel sheet includes:
a residual austenite is 0 to 3%,
wherein the base steel sheet includes:
a microstructure in which V1/V2 which is a ratio of a volume fraction V1 of the hard structure in the surface layer range and a volume fraction V2 of the hard structure in the range of ? thickness to ? thickness centered at the position of ¼ thickness from the surface of the base steel sheet is limited within a range of 0.10 or more and 0.90 or less,
a Fe content is 5.0% or less and an Al content is 1.0% or less in the hot-dip galvanized layer, and columnar grains formed of a ? phase are included, and further
a ratio ((A*/A)×100) of an interface (A*) between the ? phase and the base steel sheet in an entire interface (A) between the hot-dip galvanized plated layer and the base steel sheet is 20% or more, and
a refined layer is formed at the side of the interface in the base steel sheet, wherein an average thickness of the refined layer is 0.1 to 5.0 ?m, an average grain size of ferrite in the refined layer is 0.1 to 3.0 ?m, one or two or more of oxides of Si and Mn are contained, and a maximum size of the oxide is 0.01 to 0.4 ?m.

US Pat. No. 10,113,221

BEARING STEEL

AKTIEBOLAGET SKF, Gothen...

1. A method of heat treating a bearing component composed of a steel alloy composition that comprises:0.6 to 0.7 wt. % carbon,
1.3 to 1.7 wt. % silicon,
1.2 to 1.6 wt. % manganese,
0.8 to 1.2 wt. % chromium,
0.15 to 0.4 wt. % molybdenum,
0.05 to 0.25 wt. % nickel,
0.003 to 0.01 wt. % vanadium,
0.005 to 0.05 wt. % aluminium,
0.05 to 0.3 wt. % copper,
0 to 0.5 wt. % cobalt,
0 to 0.1 wt. % niobium,
0 to 0.1 wt. % tantalum,
0 to 150 ppm nitrogen, and
0 to 50 ppm calcium,
the balance being iron and 0.3 wt. % or less of unavoidable impurities,
the method comprising:
(i) heating the steel alloy composition at a temperature of 865-900° C. for 50-100 minutes to at least partially austenitise the composition;
(ii) quenching the steel alloy composition to a temperature of 190-210° C. and holding the steel alloy composition at the temperature of 190-210° C. for 12-36 hours;
(iii) isothermally heating the steel alloy composition at a temperature of 200-280° C. until the steel alloy composition has a microstructure that comprises 5 to 10 vol.% retained austenite and at least 80 vol. % bainitic-ferrite and has a Vickers hardness of at least 650 HV; and
(iv) subjecting the bearing component having 5 to 10 vol.% retained austenite and at least 80 vol. % bainitic-ferrite to a surface finishing technique.

US Pat. No. 10,113,216

QUASICRYSTAL AND ALUMINA MIXED PARTICULATE REINFORCED MAGNESIUM-BASED COMPOSITE MATERIAL AND METHOD FOR MANUFACTURING THE SAME

NORTH UNIVERSITY OF CHINA...

1. A quasicrystal and alumina mixture particles reinforced magnesium matrix composite comprising:a quasicrystal and alumina mixture particles reinforcement phase; and
a magnesium alloy matrix;
the weight ratio of the quasicrystal and alumina mixture particles reinforcement phase to the magnesium alloy matrix being (4-8) to 100,
the magnesium alloy matrix comprising by weight 1000 parts of magnesium, 90 parts of aluminum, 10 parts of zinc, 1.5-5 parts of manganese, 0.5-1 part of silicon and 0.1-0.5 part of calcium, and
the quasicrystal and alumina mixture particles reinforcement phase comprising by weight 40 parts of magnesium, 50-60 parts of zinc, 5-10 parts of yttrium and 8-20 parts of nanometer alumina particles of which the diameter is 20-30 nm.

US Pat. No. 10,113,214

ALKALI METAL AND/OR ALKALI EARTH METAL EXTRACTION METHOD

AISIN SEIKI KABUSHIKI KAI...

1. A method for extracting at least one of an alkali metal and an alkali earth metal from a solid containing at least one of the alkali metal and the alkali earth metal, the method comprisingadding the solid to a neutral amino acid-containing aqueous solution so as to elute at least one of the alkali metal and the alkali earth metal in the neutral amino acid-containing aqueous solution,
contacting an acidic gas with the eluted at least one of the alkali metal and the alkali earth metal in the neutral amino acid-containing aqueous solution to precipitate the at least one of the alkali metal and the alkali earth metal as a salt,
recovering the salt,
adding another solid containing at least one of an alkali metal and an alkali earth metal to the neutral amino acid-containing aqueous solution from which the salt was recovered to elute at least one of the alkali metal and the alkali earth metal in the neutral amino acid-containing aqueous solution, and
determining a mixing ratio of water, the neutral amino acid and the solid so that peak values of a rate of elution and an amount of the salt precipitated are matched, the rate of elution being obtained by dividing an amount of the at least one of the alkali metal and the alkali earth metal eluted in the neutral amino acid-containing aqueous solution by an amount of the at least one of the alkali metal and the alkali earth metal contained in the solid, or an integrated value of the rate of elution and the amount of the salt precipitated is maximized,
wherein the neutral amino acid-containing aqueous solution has an isoelectric point within a range of ±1.5 with respect to a first acid dissociation constant of the acidic gas, and the neutral amino acid is DL-alanine and is a chelating agent that reacts with at least one of the alkali metal and the alkali earth metal to form a chelated complex.

US Pat. No. 10,113,210

HEAT TREATMENT APPARATUS FOR CYLINDER BLOCK AND HEAT TREATMENT METHOD FOR CYLINDER BLOCK

TOYOTA JIDOSHA KABUSHIKI ...

1. A heat treatment apparatus for a cylinder block, the heat treatment apparatus performing heat treatment by feeding gas, the heat treatment apparatus comprising:a first feed part configured to feed the gas toward bores of the cylinder block, from a first side or a second side of the bores in an axis direction of the bores; and
a second feed part configured to feed the gas toward a lateral surface of the cylinder block from the first side or the second side, the lateral surface of the cylinder block extending in an array direction of the bores,
wherein the first feed part includes a first feed hole that is a jet orifice for the gas,
wherein the second feed part includes a second feed hole that is a jet orifice for the gas, and
wherein at least one of the first feed hole and the second feed hole is a slit along the array direction of the bores of the cylinder block.

US Pat. No. 10,113,209

METHODS AND SYSTEMS FOR PRODUCING HIGH CARBON CONTENT METALLIC IRON USING COKE OVEN GAS

MIDREX TECHNOLOGIES, INC....

1. A method for producing high carbon content metallic iron using coke oven gas, comprising:dividing a top gas stream from a direct reduction shaft furnace into a first top gas stream and a second top gas stream;
treating a coke oven gas stream from a coke oven gas source in one or more guard vessels to remove liquid droplets, aerosols, and heavy hydrocarbons from the coke oven gas stream;
mixing the first top gas stream with the treated coke oven gas stream and processing at least a portion of a resulting combined gas stream in a selective separation unit to form a synthesis gas-rich gas stream and a carbon-dioxide rich gas stream;
delivering the synthesis gas-rich gas stream to the direct reduction shaft furnace as bustle gas;
using the carbon-dioxide rich gas stream as fuel gas in one or more heating units;
delivering the second top gas stream to the direct reduction shaft furnace as bustle gas; and
delivering at least a portion of the coke oven gas stream to the direct reduction shaft furnace as a transition zone gas stream at a temperature that is lower than a temperature of the bustle gas.

US Pat. No. 10,113,195

NUCLEIC ACID AMPLIFICATION

LIFE TECHNOLOGIES CORPORA...

1. A method for amplifying a plurality of nucleic acid templates, comprising:a) providing a plurality of forward primers immobilized on a support, wherein the plurality of forward primers includes a first forward primer and a second forward primer, and wherein the plurality of forward primers have substantially identical sequences;
b) providing a nucleic acid reverse strand from the plurality of nucleic acid templates, having a forward primer-binding sequence that can hybridize to any one of the plurality of forward primers;
c) hybridizing the first forward primer to the forward primer-binding sequence on the nucleic acid reverse strand;
d) generating an extended forward strand that is substantially complementary to the nucleic acid reverse strand and is hybridized thereto, by primer extension of the first forward primer using the reverse strand as a template, wherein the first forward primer becomes incorporated into the extended forward strand;
e) denaturing at least a portion of the extended forward strand comprising the incorporated first forward primer and the forward primer-binding sequence on the nucleic acid reverse strand and hybridizing the second forward primer to the forward primer-binding sequence on the nucleic acid reverse strand;
f) generating another extended forward strand that is substantially complementary to the reverse strand and is hybridized thereto, by primer extension of the second forward primer using the reverse strand as a template, wherein the second forward primer becomes incorporated into the extended forward strand; and
g) amplifying the plurality of nucleic acid templates simultaneously in a single continuous liquid phase without first compartmentalizing, by performing one or more amplification cycles comprising steps (e)-(f) under isothermal conditions to form clonal or substantially clonal nucleic acid populations, wherein the incorporated second forward primer of step (e) of an amplification cycle acts as the incorporated first forward primer of step (e) of a subsequent amplification cycle and the second forward primer of step (e) in the subsequent amplification cycle is a new second forward primer that has not undergone primer extension; and wherein the amplifying is carried out using a recombinase and a polymerase.

US Pat. No. 10,113,194

GAS TESTING UNIT AND METHOD

LANZATECH NEW ZEALAND LIM...

1. A method comprising:(a) evaluating suitability of a test C1-containing substrate obtained from an industrial process for use in a biological conversion process comprising:
(b) providing a gas testing unit, comprising:
(i) a first bioreactor stage for evaluating the performance of a reference C1-containing substrate;
(ii) a second bioreactor stage for evaluating the performance of the test C1-containing substrate;
(iii) an analytical section configured for analysis of both gaseous and liquid products of the first and second bioreactors;
wherein the gas testing unit is capable of being housed within a container having a volume of less than about 6 m3 and transportable to multiple locations;
(c) feeding the reference C1-containing substrate to the first bioreactor of the gas testing unit containing a first culture of a C1-fixing microorganism the first bioreactor operated at a set of target operating conditions;
(d) feeding the test C1-containing substrate obtained from the industrial process to the second bioreactor of the gas testing unit containing a second culture of the C1-fixing microorganism, the second bioreactor operated at the same set of target conditions as the first bioreactor;
(e) analyzing both gaseous and liquid products of the first and second bioreactors employing the analytical section of the gas testing unit to determine the performance of the first and second bioreactors; and
(f) comparing the performance of the first bioreactor, relative to the performance of the second bioreactor to determine the suitability of the test C1-containing substrate obtained from the industrial source for use in a biological conversion process;
the process characterized in that it is carried out at a site of the industrial process.

US Pat. No. 10,113,189

ISOLATION AND CHARACTERIZATION OF A NOVEL PYTHIUM OMEGA 3 DESATURASE WITH SPECIFICITY TO ALL OMEGA 6 FATTY ACIDS LONGER THAN 18 CARBON CHAINS

BASF Plant Science GmbH, ...

1. A method for the manufacture of a composition comprising a compound having a structure of the general formula I:
wherein
R1=hydroxyl, coenzyme A (thioester), lysophosphatidylcholine, lysophosphatidylethanolamine, lysopho sphatidylglycerol, lysodipho sphatidylglycerol, lysopho sphatidylserine, lysophosphatidylinositol, sphingo base or a radical of the formula II:

R2=hydrogen, lysophosphatidylcholine, lysophosphatidylethanolamine, lysopho sphatidylglycerol, lysodipho sphatidylglycerol, lysopho sphatidylserine, lysophosphatidylinositol or saturated or unsaturated C2-C24-alkylcarbonyl, R3=hydrogen, saturated or unsaturated C2-C24-alkylcarbonyl, or R2 and R3 independently of each other are a radical of the formula Ia:

n=2, 3, 4, 5, 6, 7 or 9, m=2, 3, 4, 5 or 6 and p=0 or 3;
and
wherein said method comprises cultivating a host cell or a transgenic non-human organism comprising a polynucleotide comprising a heterologous nucleic acid sequence selected from the group consisting of:
(i) the nucleic acid sequence of SEQ ID NO: 1 or 23;
(ii) a nucleic acid sequence encoding a polypeptide comprising the amino acid sequence of SEQ ID NO: 2 or 24; and
(iii) a nucleic acid sequence encoding a polypeptide having omega-3 desaturase activity capable of converting omega-6 DPA into DHA, wherein said polypeptide has at least 95% sequence identity to the amino acid sequence of SEQ ID NO: 2 or 24,
under conditions which allow biosynthesis of said compound.

US Pat. No. 10,113,164

PICHIA PASTORIS SURFACE DISPLAY SYSTEM

Research Corporation Tech...

1. A surface display system comprising:(a) an engineered strain of Pichia pastoris comprising a mutant ?-1,6-mannosyltransferase (OCH1) allele which is transcribed into a mRNA coding for a mutant OCH1 protein, wherein the mutant OCH1 protein comprises a catalytic domain at least 95% identical with amino acids 45-404 of SEQ ID NO: 2, wherein the mutant OCH1 protein lacks an N-terminal sequence for targeting the mutant OCH1 protein to the Golgi apparatus and lacks a membrane anchor domain at the N-terminal region, and wherein said strain produce substantially homogeneous N-glycans; and
(b) a vector encoding a recombinant protein adapted to be displayed on a surface of the Pichia pastoris.

US Pat. No. 10,113,160

CARBON DIOXIDE FIXATION VIA BYPASSING FEEDBACK REGULATION

Easel Biotechnologies, LL...

1. A method for improving the efficiency of carbon dioxide fixation in an organism having a Calvin-Benson-Bassham (CBB) cycle, comprising:genetically modifying the organism having the CBB cycle to produce or overexpress a first enzyme, and to produce or overexpress a second enzyme;
wherein the first enzyme is phosphoketolase enzyme, belonging to EC 4.1.2.9 and the second enzyme is phosphoribulokinase enzyme belonging to EC 2.7.1.19;
wherein the first enzyme utilizes an intermediate of the CBB pathway as a substrate and generates a first acetyl phosphate product;
wherein the phosphoribulokinase enzyme is produced or overexpressed in an amount to achieve a phosphoribulokinase activity level that is higher than the native phosphoribulokinase activity level of the organism;
wherein the second enzyme is overexpressed in the genetically modified organism in an amount to achieve a phosphoribulokinase activity level that is higher than the native phosphoribulokinase activity level of the organism, and the second enzyme utilizes ribulose-5-phosphate to produce ribulose-1,5-bisphosphate;
wherein the first acetyl phosphate product is converted in the organism to acetyl-CoA;
wherein the genetically modified organism fixes two CO2 molecules onto two of the ribulose-1,5-bisphosphate molecules, and the reaction products are then turned over in the CBB cycle to produce one acetyl-CoA molecule from the first acetyl phosphate, when the organism is grown in culture at ammonium levels of less than 3 mM; and
wherein the production of phosphoenolpyruvate (PEP) in the genetically modified organism, when grown under nitrogen depletion, is below a feedback inhibitory concentration for the CBB cycle.

US Pat. No. 10,113,152

VARIANT POLYPEPTIDES CAPABLE OF AMINATING ALIPHATIC ALPHA KETO ACIDS

AbbVie Inc., North Chica...

1. A polypeptide, comprising:(a) the amino acid sequence of any one of SEQ ID NOS:2 and 13-18, wherein X is not leucine;
(b) an amino acid sequence that is at least 95% identical to: (i) amino acids 6 to 238 of SEQ ID NO:2; (ii) amino acids 7 to 237 of SEQ ID NO:13; (iii) amino acids 4 to 236 of SEQ ID NO:14; (iv) amino acids 4 to 236 of SEQ ID NO:15; (v) amino acids 4 to 236 of SEQ ID NO:16; (vi) amino acids 4 to 236 of SEQ ID NO:17; or (vii) amino acids 4 to 236 of SEQ ID NO:18, wherein X is not leucine;
(c) an amino acid sequence that is at least 95% identical to: (i) amino acids 6 to 298 of SEQ ID NO:2; (ii) amino acids 7 to 297 of SEQ ID NO:13; (iii) amino acids 4 to 296 of SEQ ID NO:14; (iv) amino acids 4 to 296 of SEQ ID NO:15; (v) amino acids 4 to 296 of SEQ ID NO:16; (vi) amino acids 4 to 296 of SEQ ID NO:17; or (vii) amino acids 4 to 296 of SEQ ID NO:18, wherein X is not leucine; or
(d) the amino acid sequence of SEQ ID NO: 4, 5, 6, or 20;
wherein the polypeptide is isolated and wherein the polypeptide has the ability to convert 2-oxonon-8-enoic acid, in the presence of an ammonia source, to 2-aminonon-8-enoic acid; and
X is isoleucine, valine, glycine, alanine, serine, or threonine.

US Pat. No. 10,113,145

PAENIBACILLUS SP. STRAIN, CULTIVATION METHOD AND USE OF THE SAME

1. An extracellular polysaccharide of Paenibacillus, wherein the structural formula of the extracellular polysaccharide shown in Formula (1),
wherein, n=15-30;
wherein the extracellular polysaccharide is purified and free of non-carbohydrate structure including protein, sulfide and amidogen;
wherein the extracellular polysaccharide has an average molecular weight distribution of 2500 to 5000 Da; and/or has following appearance: pure white filament or powder; wherein the extracellular polysaccharide is produced by Paenibacillus bovis sp. nov. BD3526 whose deposit number is CGMCC No. 8333.

US Pat. No. 10,113,144

METHOD FOR PRODUCING CELL CONCENTRATE, AND CELL SUSPENSION TREATMENT SYSTEM

KANEKA CORPORATION, Osak...

1. A method for producing a cell concentrate using a cell suspension treatment system including:a storage container of a cell suspension, which has a solution inlet port, a circulation outlet port, and a circulation inlet port;
a cell suspension treatment device for concentrating the cell suspension by separating liquid from the cell suspension by filtration, the device including a container having a cell suspension introduction port, a cell suspension lead-out port, and a filtrate outlet, which is filled with a hollow fiber separation membrane,
a circulation circuit for concentrating the cell suspension while circulating the cell suspension between the storage container and the cell suspension treatment device, the circuit being constituted by an introduction communication tube communicating the circulation inlet port of the storage container and the cell suspension introduction port of the cell suspension treatment device and a lead-out communication tube communicating the cell suspension lead-out port of the cell suspension treatment device and the circulation outlet port of the storage container;
a collection container of a cell concentrate obtained by concentration;
a collection path for feeding the cell concentrate in the storage container, the cell suspension treatment device, and the circulation circuit to the collection container;
an injection path for injecting a solution into the solution inlet port of the storage container;
a detecting unit for detecting a volume of the cell concentrate in the storage container or the introduction communication tube of the circulation circuit, and
an air bubble sensor on a path from the storage container to an air filter, wherein the air filter is provided above the storage container so as to make a pressure of an inner portion of the storage container to an atmospheric pressure,
the method comprising:
a) a step of storing the cell suspension in the storage container by supplying the cell suspension to the storage container through the solution inlet port;
b) a step of concentrating the cell suspension by feeding the cell suspension in the storage container to the cell suspension treatment device through the introduction communication tube of the circulation circuit, and then, circulating the cell suspension into the storage container through the lead-out communication tube of the circulation circuit;
c) a step of terminating the step b) by detecting the volume of the cell concentrate in the storage container or the introduction communication tube of the circulation circuit; and
d) a step of feeding and collecting the cell concentrate in the storage container, the cell suspension treatment device, and the circulation circuit to the collection container through the collection path.

US Pat. No. 10,113,143

CELL CULTURE BAG AND METHOD FOR MANUFACTURING CELL CULTURE BAG

Yokogawa Electric Corpora...

1. A cell culture bag comprising:an external film;
at least one sensor chip arranged on an inner surface of the external film, the at least one sensor chip including a layer reacting to an object to be detected, the inner surface being on a culture fluid side of the external film; and
a permeable film that covers a culture fluid side of the sensor chip, the permeable film permeating the object to be detected,
wherein the permeable film covers the entire inner surface of the external film,
wherein the at least one sensor chip comprises a plurality of sensor chips arranged into a plurality of groups,
wherein a group of sensor chips having the largest size is arranged at the center of the plurality of groups, the remaining groups of sensor chips having a smaller size being arranged around the group of sensor chips having the largest size, and
wherein the group of sensor chips having the largest size is configured to generate a stronger signal than the remaining groups of sensor chips having a smaller size.

US Pat. No. 10,113,141

CLEANING LIQUID FOR SEMICONDUCTOR DEVICE AND METHOD FOR CLEANING SUBSTRATE FOR SEMICONDUCTOR DEVICE

MITSUBISHI CHEMICAL CORPO...

1. A cleaning liquid for a semiconductor device, comprising the following components (1)? to (4)?:(1)? an inorganic alkali;
(2)? a carboxyl group-containing chelating agent, which is at least one amino acid selected from the group consisting of cysteine and histidine;
(3)? an anionic surfactant which is at least one of a benzenesulfonic acid substituted with an alkyl group having from 8 to 20 carbon atoms and a salt thereof; and
(4)? water,
wherein the cleaning liquid has a pH of 9 or more.

US Pat. No. 10,113,131

PHOSPHONO PARAFFINS

THE BOEING COMPANY, Chic...

1. A phosphono paraffin represented by formula (I):
wherein:
each instance of R1 is independently —H or

each instance of R2 and R3 is independently C1-20 alkyl, cycloalkyl of C20 or less, or aryl;
n is an integer between 4 and 22;
and the number of instances where R1 is
of formula (I) is between about 2 and about 8.

US Pat. No. 10,113,130

HIGH DENSITY/HIGH CETANE RENEWABLE FUEL BLENDS

The United States of Amer...

1. A method for making a diesel fuel blend or a jet fuel blend, comprising:(i) cycloaddition of renewable alkenes, ketones, or aldehydes to prepare multicyclic alkanes or multicyclic alkenes, (ii) converting norbornadiene to multicyclic alkanes or multicyclic alkenes, (iii) converting cyclopentadiene or a functionalized cyclopentadiene to multicyclic alkanes or multicyclic alkenes, or (iv) converting cyclooctatetraene to multicyclic alkanes or multicyclic alkenes;
preparing a synthetic paraffinic kerosene and mixing said synthetic paraffinic kerosene with the multicyclic alkanes or multicyclic alkenes prepared by one of steps (i)-(iv) to produce said deisel fuel blend with a cetane number>40 or said jet fuel blend with a viscosity below 8.5 cSt at ?20° C.

US Pat. No. 10,113,127

PROCESS FOR SEPARATING NITROGEN FROM A NATURAL GAS STREAM WITH NITROGEN STRIPPING IN THE PRODUCTION OF LIQUEFIED NATURAL GAS

1. A process for producing liquefied natural gas from a nitrogen-containing natural gas stream, the process comprising:a) cooling a stream of mixed refrigerant in a first heat exchanger of a single closed-loop mixed refrigerant system to provide a cooled mixed refrigerant stream;
b) expanding at least a portion of the cooled mixed refrigerant stream to produce an expanded mixed refrigerant stream;
c) cooling and at least partially condensing the natural gas stream in a first heat exchange passageway via indirect heat exchange with the expanded mixed refrigerant stream in the first heat exchanger to produce a cooled natural gas stream;
d) dividing the cooled natural gas stream withdrawn from the first heat exchange passageway into a first portion and a second portion;
e) introducing the first portion into a lower inlet of a first vapor-liquid separator;
f) subsequent to said dividing, subcooling the second portion in the first heat exchanger to provide a subcooled liquid portion, wherein said subcooling is carried out in a second heat exchange passageway via indirect heat exchange with said expanded mixed refrigerant;
g) subsequent to said subcooling, introducing the subcooled liquid portion into an upper inlet of the first vapor-liquid separator, wherein the upper inlet of the first vapor-liquid separator is located at a higher vertical elevation than the lower inlet;
h) withdrawing a methane rich liquid bottoms stream and a first nitrogen rich vapor overhead stream from the first vapor-liquid separator;
i) further cooling the methane rich liquid bottoms stream in the first heat exchanger in a third heat exchange passageway to provide a first liquid natural gas stream;
j) introducing at least a portion of the first liquid natural gas stream into an inlet of a nitrogen stripping column;
k) introducing at least a portion of the first nitrogen rich vapor overhead stream into another inlet of the nitrogen stripping column;
l) withdrawing a stream of nitrogen-depleted liquefied natural gas (LNG) from a lower portion of the nitrogen stripping column, wherein the LNG comprises less than 3 volume percent nitrogen;
m) recovering an overhead nitrogen rich vapor stream from a location near the top of the nitrogen stripping column, wherein the overhead nitrogen rich vapor stream comprises less than 3 volume percent methane;
n) introducing the overhead nitrogen rich vapor stream into the first heat exchanger; and
o) using at least a portion of the overhead nitrogen rich vapor stream as a refrigerant in the first heat exchanger to carry out at least a portion of the cooling of step (a) and/or at least a portion of the cooling of step (c), wherein the single closed-loop mixed refrigerant system is the only closed-loop refrigeration system used to cool the natural gas stream.

US Pat. No. 10,113,126

REUSABLE POLYMERIC MATERIAL FOR REMOVING SILOXANE COMPOUNDS IN BIOGAS, METHOD THEREBY AND APPARATUS THEREFOR

KOREA INSTITUTE OF SCIENC...

1. A polyacrylate-based polymer absorbent for removing siloxane compounds from biogas, comprising:particles of poly(meth)acrylate salt, cations of the salt being other than sodium;
hygroscopic inorganic particles, anions of the inorganic particles selected from the group consisting of chloride, bromide and iodide, cations of the inorganic particles including sodium; and
a porous support.

US Pat. No. 10,113,125

METHOD AND SYSTEM FOR COGENERATING GAS-STEAM BASED ON GASIFICATION AND METHANATION OF BIOMASS

SUNSHINE KAIDI NEW ENERGY...

1. A system for cogenerating gas-steam based on gasification and methanation of biomass, the system comprising:a gasification unit comprising a gasifier, the gasifier comprising an upper part that is disposed higher with respect to the ground than the remaining parts of the gasifier, a waste heat boiler, an external thermostatic heater, and an outlet segment;
a shift unit;
a purification unit;
a methanation unit; and
a methane concentration unit;wherein:the gasifier is adapted to yield a crude gasified gas;
the waste heat boiler is connected to the upper part;
the waste heat boiler is adapted to recycle waste heat of the crude gasified gas to yield a first intermediate pressure superheated steam;
the external thermostatic heater is disposed at the outlet segment to keep a gasification temperature within the gasifier at 1,500-1,800° C.; and
the purification unit is adapted to purify the crude gasified gas to yield a purified syngas.

US Pat. No. 10,113,123

PROCESS AND SYSTEM FOR EXTRACTION OF A FEEDSTOCK

1. A system for recovering aromatics from a naphtha feedstock, comprising:(a) a naphtha splitter for separating a C6+ fraction from the naphtha feedstock;
(b) a hydrotreater unit to desulphurize and separate a C6 to C11 hydrocarbon fraction from the C6+ fraction;
(c) an aromatics extraction distillation unit for recovering from the C6 to C11 hydrocarbon fraction an aromatics fraction, an aromatics precursors fraction and a raffinate fraction;
(d) a dehydrogenation unit or a reformer for converting the aromatics precursors in the aromatics precursors fraction to aromatics; and
wherein the naphtha splitter, the hydrotreater unit, and the aromatic extraction distillation unit, are operatively connected such that the C6+ fraction and the C0 to C11 hydrocarbon fraction are not subjected to a reformer or a dehydrogenation unit prior to the recovery of the aromatics fraction, the aromatics precursors fraction and the raffinate fraction.

US Pat. No. 10,113,122

PROCESS FOR UPGRADING HEAVY HYDROCARBON LIQUIDS

UNIVERSITY OF NEW BRUNSWI...

1. A hydrogen-free process for upgrading heavy hydrocarbon liquids, comprising:a) mixing a pre-heated heavy hydrocarbon liquid feedstock with glycerol and a catalyst to form a mixture, wherein the mixture has a heavy hydrocarbon liquid feedstock to glycerol weight ratio from about 5000:1 to about 100:10 and a heavy hydrocarbon liquid feedstock to catalyst weight ratio from about 5000:1 to about 100:10;
b) feeding the mixture into a first reactor comprising propellers, heated up to a temperature in a range from about 200° C. to about 450° C. to partially treat the mixture, maintaining a pressure in the first reactor in a range from about 0.6 MPa to about 0 MPa absolute, and driving said propellers to apply shear forces to the mixture in a range from about 300 N/m2 to about 10000 N/m2;
c) after a preselected period of time, flowing the partially treated mixture to a second reactor having a holding volume larger than the first reactor, heated up to a temperature in a range from about 250° C. to about 380° C. and maintaining a pressure in the second reactor in a range from about 0.6 MPa to about 0 MPa absolute to further treat the partially treated mixture, said second reactor having a bottom with a bottom exit port and top exit port such that first hydrocarbon fractions are separated from second hydrocarbon fractions, wherein the first hydrocarbon fractions have a boiling point higher the second hydrocarbon fractions, and the second hydrocarbon fractions are vaporized and flow up through the top exit and collected into a distillation column, and said first hydrocarbon fractions sink to the bottom of the second reactor and are flowed out through the bottom exit port and recirculated back to the first reactor; and
d) collecting an upper portion of the second hydrocarbon fractions separated from a lower portion of the second hydrocarbon fractions in the distillation column out through an upper exit port and storing the collected upper portion of the second hydrocarbon fractions, and collecting the lower portion of the second hydrocarbon fractions out through a lower exit port and storing the collected lower portion of the second hydrocarbon fractions, wherein the upper portion of the second hydrocarbon fractions has a boiling point lower than the lower portion of the second hydrocarbon fractions, wherein the process is carried out with no external hydrogen gas.

US Pat. No. 10,113,121

GASOLINE PRODUCTION PROCESS COMPRISING AN ISOMERIZATION STEP FOLLOWED BY AT LEAST TWO SEPARATION STEPS

AXENS, Rueil Malmaison (...

1. A process for the isomerization of a light naphtha, said process comprising an isomerization reaction step (1), said step being carried out under the following conditions:a temperature in the range 100° C. to 300° C.,
a pressure of 2 to 35 bar (1 bar=0.1 MPa), and
a molar ratio of hydrogen/hydrocarbons in the range 0.1/1 to 1/1,
a space velocity of 0.5 to 10 h?1,
the catalysts used being constituted by a support of high purity alumina comprising 2% to 10% by weight of chlorine, 0.1% to 0.40% by weight of platinum, and optional other metals, said isomerization step being followed by a step (2) for stabilization of the reaction effluents, and by two steps for separation by distillation of the bottom stream obtained from the stabilization step (2) which are placed downstream of the stabilization step (2), the two separation steps being as follows:
1—a first step for separation by distillation (block (3+4) in order to separate the hydrocarbons containing 5 carbon atoms from heavier compounds sent towards the second section for distillation by separation (5), said first separation step producing the following 3 cuts: a) a cut which is enriched in isopentane (15) which is a product of the process, b) a cut which is enriched in n-pentane (16) which is recycled to the reaction section (1), and c) a cut which is enriched in hydrocarbons which are heavier than pentanes (17), which is directed towards a second separation step (5), (5), consisting of a separation column wherein the overhead stream (19) which is rich in C6 branched compounds and bottom stream (18), are the products from the unit and an intermediate cut (20) which is enriched in n-hexane, removed as a side stream which is recycled to the reaction section (1), in which in an isomerization process an exchange of heat is carried out between a condenser of one of the columns (3), (4) or (5) and the reboiler of one of columns (3), (4) or (5).

US Pat. No. 10,113,119

THERMALLY STABLE MONOLITH CATALYST FOR REFORMING REACTION

KOREA RESEARCH INSTITUTE ...

1. A thermally stable monolith catalyst for reforming reaction, comprising:an active ingredient and Group 1A to 5A metal of barrier components represented by Formula 1 below on a monolith catalyst support, wherein the active ingredient of Formula 1 has 0.5 to 10 parts by weight based on 100 parts by weight of a monolith catalyst,
a(X)-b(Y)  Formula 1
wherein X is a catalytic active ingredient selected from Co, Ni, Ru, Rh and a mixture thereof, Y is a mixture of Zr as a promoter and Group 1A to 5A metals as a barrier component in a mixing ratio by weight of 1:0.1 to 1:10, and ‘a’ and ‘b’ denote the ratios by weight of X and Yin order, wherein ‘a’ is 1 and ‘b’ ranges from 0.2 to 1.5.

US Pat. No. 10,113,118

PROCESS AND APPARATUS FOR PRODUCING HYDROCARBON

1. Method for producing liquid hydrocarbon by converting carbonaceous material contained in one or more feedstocks, the method comprisingProviding a feed material;
Pressurizing the feed material to a predetermined process pressure of 150 to 400 bar;
Heating the pressurized feed material to a predetermined process temperature of 370 to 500° C.;
Reacting the pressurized and heated feed material for a predetermined period of time;
Cooling the reacted feed material to a temperature below 200° C.;
Mechanically separating the converted feed material at operational pressure into a higher viscosity fraction and a lower viscosity fraction, and extracting the higher viscosity fraction from the process through alternating mechanical filters between at least one online filter and at least one offline filter, the temperature of the filters being controlled to be in the range 40 to 200° C.; and
Conveying the remaining converted feed mass including the lower viscosity fraction through a pressure reduction system and further through a separation system.

US Pat. No. 10,113,117

VERTICAL ALIGNMENT LIQUID CRYSTAL DISPLAY AND MANUFACTURE METHOD THEREOF

Shenzhen China Star Optoe...

1. A manufacture method of a vertical alignment liquid crystal display, comprising steps of:step 1, loading a first substrate and a second substrate;
wherein a first passivation layer and a second passivation layer are respectively located on inner sides of the first substrate and the second substrate, and a common electrode layer and a pixel electrode layer are respectively located on the first passivation layer and the second passivation layer;
step 2, coating a glue frame on the first substrate or the second substrate;
step 3, filling a liquid crystal layer in a district surrounded by the glue frame;
wherein the liquid crystal layer comprises liquid crystal molecules, auxiliary alignment agent and polymeric monomers; and
a weight percentage of the polymeric monomers in the liquid crystal layer is 0.5%-0.8%;
step 4, assembling the first substrate and the second substrate; and
step 5, applying a voltage to the common electrode layer and the pixel electrode layer to make the liquid crystal molecules of the liquid crystal layer twisted with a predetermined degree, and employing ultraviolet (UV) light to irradiate the liquid crystal layer;
wherein the polymeric monomers are polymerized to form a polymer network penetrating the entire liquid crystal layer; and
wherein each of the polymeric monomers has at least two polymerizable groups;
wherein the polymeric monomers comprise at least one double polymerizable group monomer having two polymerizable groups and at least one polymeric group compound having at least three polymerizable groups; and a weight percentage of the polymeric group compound in the polymerizable monomers is 10%-50%.

US Pat. No. 10,113,115

NEMATIC LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE USING THE SAME

DIC CORPORATION (TOKYO), ...

1. A liquid crystal composition having a negative dielectric anisotropy, the composition comprising a first component that is at least one compound represented by General Formula (i)(where Ri1 represents an alkyl group having 1 to 8 carbon atoms, and Ri2 represents an alkyl group having 3 to 8 carbon atoms) anda second component that is at least e compound selected from compounds represented by General Formula (L)(where RL1 and RL2 each independently represent an alkyl group having 1 to 8 carbon atoms; in the alkyl group, one —CH2— or at least two —CH2-'s not adjoining each other are each independently optionally substituted with —CH?CH—, —C?C—, —O—, —CO—, —COO—, or —OCO—;nL1 represents 0, 1, 2, or 3;
AL1, AL2, and AL3 each independently represent a group selected from the group consisting of(a) a 1,4-cyclohexylene group (in which one —CH2— or at least two —CH2—'s not adjoining each other are each optionally substituted with —O—),(b) a 1,4-phenylene group (in which one —CH? or at least two —CH?'s not adjoining each other are each optionally substituted with —N?), and(c) a naphthalene-2,6-diyl group, a 1,2,3,4-tetrahydronaphthalene-2,6-diyl group, or a decahydronaphthalene-2,6-diyl group (in the naphthalene-2,6-diyl group or the 1,2,3,4-tetrahydronaphthalene-2,6-diyl group, one —CH? or at least two —CH?'s not adjoining each other are each optionally substituted with —N?);the groups (a) to (c) are each independently optionally substituted with a cyano group, a fluorine atom, or a chlorine atom;ZL1 and ZL2 each independently represent a single bond, —CH2CH2—, —(CH2)4—, —OCH2—, —CH2O—, —COO—, —OCO—, —OCF2—, —CF2O—, —CH?N—N?CH—, —CH?CH—, —CF?CF—, or —C?C—;
in the case where nL1 is 2 or 3 and where AL2 is multiple, the multiple AL2's may be the same as or different from each other; in the case where nL1 is 2 or 3 and where ZL3 is multiple, the multiple ZL3's may be the same as or different from each other; and the compound represented by General Formula (L) excludes the compound represented by General Formula (i)).

US Pat. No. 10,113,113

REMOVING POLYSILICON

Micron Technology, Inc., ...

1. A method, comprising:forming a first instance of oxide;
forming an instance of polysilicon over the instance of oxide;
forming a second instance of oxide over the instance of polysilicon;
forming an opening through the second instance of oxide, the instance of polysilicon and the first instance of oxide;
exposing the second instance of oxide, the instance of polysilicon and the first instance of oxide to an aqueous composition; and
using the aqueous composition, recessing the instance of polysilicon relative to the first instance of oxide and the second instance of oxide within the opening;
wherein the aqueous composition comprises nitric acid, poly-carboxylic acid and ammonium fluoride.

US Pat. No. 10,113,106

STRENGTH-ENHANCING RESIN FOR PROPPANT

Halliburton Energy Servic...

1. A method of fracturing a subterranean formation comprising:introducing a fracturing fluid into the subterranean formation, wherein the fracturing fluid comprises:
(A) a base fluid;
(B) proppant; and
(C) a curable resin having three or more epoxy functional group, wherein the curable resin is selected from the group consisting of trimethylolpropane trialycidyl ether, glycerol trialycidyl ether, pentaerythritol tetraalycidyl ether, glycerol polyethylene oxide trialycidyl ether, glycerol polypropylene oxide trialycidyl ether, polyalycerol-3-polyalycidyl ether, polyalycerol-3-olyethylene oxide polyalycidyl ether, polyalycerol-3-polypropylene oxide polyalycidyl ether, and combinations thereof;
wherein the curable resin is pre-coated onto the proppant prior to introduction into the subterranean formation;
creating or enhancing one or more fractures within the subterranean formation using the fracturing fluid;
then introducing a curing agent into the subterranean formation; and
allowing or causing to allow the curing agent to contact the curable resin in the subterranean formation; wherein the curable resin does not substantially cure prior to contacting the curing agent; wherein the curable resin cures when in contact with the curing agent; wherein the curable resin forms polymer molecules with the curing agent, and wherein the polymer molecules are non-linear or multi-directional polymers; wherein at least some of the three or more epoxy functional groups cross-link the polymer molecules together; wherein the curable resin and the curing agent form a multi-directional, cross-linked polymer network; and
wherein the cured resin increases the compressive strength of the proppant, wherein the compressive strength of the proppant is increased to a strength of at least 5,000 pounds force per square inch.

US Pat. No. 10,113,105

HYDROPHOBIZING AGENTS COMPRISING AN OLIGOMERIC POLYAMINE AND METHODS FOR COATING PARTICULATES THEREWITH

Halliburton Energy Servic...

1. A method comprising:providing a composition comprising:
a hydrophobizing agent comprising an oligomeric polyamine having a carbon atom:nitrogen atom ratio of about 4:1 or more, and a plurality of hydrophobic groups bonded to at least a portion of the nitrogen atoms in the oligomeric polyamine; and
forming coated particulates comprising a coating of the hydrophobizing agent on one or more particulates,
wherein the hydrophobizing agent is cationic and comprises at least one of: one quaternized nitrogen atom, or one protonated nitrogen atom.

US Pat. No. 10,113,104

SUPERHYDROPHIC FLOW CONTROL DEVICE

Halliburton Energy Servic...

1. A wellbore subassembly, comprising:a flow control device having a helical enclosed production flow path toward a production tubing, the helical enclosed production flow path being positioned circumferentially about the production tubing, wherein the helical enclosed production flow path includes a superhydrophobic coating on an inner surface of the helical enclosed production flow path for restricting production of an unwanted fluid toward the production tubing, the superhydrophobic coating having a contact angle with a water droplet in the unwanted fluid that exceeds 150°, and wherein the superhydrophobic coating is operable for increasing a velocity of fluid having a greater concentration of oil flowing along the production flow path, wherein the inner surface of the helical enclosed production flow path has a plurality of protrusions.

US Pat. No. 10,113,102

ACTIVITY ENHANCED SCALE DISPERSANT FOR TREATING INORGANIC SULFIDE SCALES

Multi-Chem Group, LLC, S...

14. A composition comprising:a base fluid;
a scale inhibitor, wherein the scale inhibitor comprises a phosphonate;
a water clarifying agent, wherein the water clarifying agent comprises at least one compound selected from the group consisting of: a polyDADMAC, a DADMAC acrylamide copolymer, and any combination thereof; and
a sulfide precipitate.

US Pat. No. 10,113,101

COMPOSITION AND METHOD FOR DISPERSING PARAFFINS IN CRUDE OILS

Ecolab USA Inc., St. Pau...

1. A method for reducing paraffin or wax deposition in a crude oil storage or transportation vessel, the method comprising adding a composition to a crude oil in an amount effective to reduce paraffin or wax deposition in the storage or transportation vessel containing the crude oil, wherein the crude oil has an API gravity of at least 33 and the composition comprisesa copolymer which is a product of a polymerization reaction comprising (i) an alpha olefin monomer and a maleic anhydride monomer, (ii) the alpha olefin monomer and an alkyl maleic anhydride monomer, (iii) the maleic anhydride monomer and styrene; or (iv) the alkyl maleic anhydride monomer and styrene, the alpha olefin monomer having the formula (I):
wherein R1 is hydrogen or C12-C30 alkyl and R2 is C12-C30 alkyl, and the alkyl maleic anhydride monomer having the formula (II):wherein R3 is C12-C30 alkyl and R4 is hydrogen or C12-C30 alkyl;an anionic surfactant; and
a solvent; and
wherein if the copolymer is the product of the polymerization reaction comprising (i) the alpha olefin monomer and the maleic anhydride monomer, R1 is hydrogen and R2 is C24-C30 alkyl.

US Pat. No. 10,113,097

PROCESS FOR THE PRODUCTION OF A THERMALLY CONDUCTIVE ARTICLE

1. A process for the production of a thermally conductive article, said process comprising:pleating at least one thermally anisotropic sheet having a first thermal conductivity in a first plane which is higher than a second thermal conductivity in a second plane that is perpendicular to the first plane to form a pleated structure, said pleated structure comprises a plurality of pleats, each said pleat having a first surface and a second surface; and
compacting the pleated structure so that said first and second surfaces which face each other due to the formation of said pleats are at least partially brought into direct contact with each other, said pleated structure having an upper surface and a lower surface,
wherein the thermally anisotropic sheet includes at least one thermally anisotropic polymer layer.

US Pat. No. 10,113,095

REINFORCED GRAPHITIC MATERIAL

MICROSOFT TECHNOLOGY LICE...

1. A method for making a reinforced graphitic material, the method comprising:sorbing a solution of an organic compound into void space between graphitic platelets of a graphitic host material;
mechanically pressing the graphitic host material while heating the graphitic host material to evaporate a solvent of the solution and deposit sorbed organic compound into the void space;
heating the graphitic host material with the sorbed organic compound to pyrolyze the sorbed organic compound and thereby deposit elemental carbon in the void space, the elemental carbon crosslinking the graphitic platelets of the graphitic host material; and
after heating the graphitic host material with the sorbed organic compound to pyrolyze the sorbed organic compound, mechanically re-pressing while heating the graphitic host material.

US Pat. No. 10,113,089

ARTICLES AND METHODS COMPRISING POLYACRYLATE PRIMER WITH NITROGEN-CONTAINING POLYMER

3M Innovative Properties ...

1. An optical film stack comprising:a first optical film bonded to a microstructured surface layer comprising microstructured prisms, of a second optical film with a cured adhesive layer comprising an interpenetrating network of the reaction product of a polyacrylate and polymerizable monomer; wherein the second optical film further comprises a primer layer disposed between the cured adhesive layer and the microstructured surface layer of the second optical film and the primer layer consists essentially of a polyacrylate and a nitrogen-containing polymer, and wherein at least a portion of the prisms comprise a post extending from an apex of the prisms that functions as a optically non-active bonding portion.

US Pat. No. 10,113,086

EXPANDABLE TAPE

1. A hanging system in a room of a building comprising:at least one of a wall and a ceiling;
a sheet; and
wherein a first side of the sheet is connected to the at least one of the wall and the ceiling by a first widthwise expandable tape and a second widthwise expandable tape, wherein the first widthwise expandable tape is spaced apart from the second widthwise expandable tape, each of the first widthwise expandable tape and second widthwise expandable tape comprising:
a first adhesive strip defining one lengthwise edge of the widthwise expandable tape;
a second adhesive strip defining the other lengthwise edge of the widthwise expandable tape;
a flexible region connecting the first adhesive strip to the second adhesive strip, the flexible region adapted to lengthen and contract to allow a movement of the second adhesive strip away from and towards the first adhesive strip in a widthwise direction of the widthwise expandable tape upon an application of a force to at least one of the first adhesive strip and the second adhesive strip;
wherein the first widthwise expandable tape comprises a first quantity of adhesive on a bottom face of the first adhesive strip, and comprises a second quantity of adhesive disposed on a bottom face of the second adhesive strip, the bottom face of the second adhesive strip facing a same direction as the bottom face of the first adhesive strip.

US Pat. No. 10,113,083

RESIST UNDERLAYER FILM-FORMING COMPOSITION CONTAINING POLYMER WHICH CONTAINS NITROGEN-CONTAINING RING COMPOUND

NISSAN CHEMICAL INDUSTRIE...

1. A resist underlayer film-forming composition for lithography comprising a linear polymer that is obtained by a reaction of a diepoxy group-containing compound (A) with a dicarboxyl group-containing compound (B), wherein the linear polymer has structures of the following formulae (1), (2), and (3) derived from the diepoxy group-containing compound (A) or the dicarboxyl group-containing compound (B):
in Formula (1), X1 is a group of Formula (4), (5), or (6):

wherein each of R1, R2, R3, and R4 is a hydrogen atom, a C1-6 alkyl group, a C3-6 alkenyl group, benzyl group, or phenyl group, the phenyl group may be substituted by a group selected from the group consisting of a C1-6 alkyl group, a halogen atom, a C1-6 alkoxy group, a nitro group, a cyano group, a hydroxyl group, and a C1-6 alkylthio group, and R1 and R2 or R3 and R4 may be bonded to each other to form a C3-6 ring; and R5 is a C1-6 alkyl group, a C3-6 alkenyl group, benzyl group, or phenyl group, and the phenyl group may be substituted by a group selected from the group consisting of a C1-6 alkyl group, a halogen atom, a C1-6 alkoxy group, a nitro group; a cyano group, a hydroxyl group, and a C1-6 alkylthio group; and
Ar in Formula (2) is an aromatic C6-20 fused ring, and the ring may be substituted by a group selected from the group consisting of a C1-6 alkyl group, a halogen atom, a C1-6 alkoxy group, a nitro group, a cyano group, a hydroxyl group, and a C1-6 alkylthio group, wherein
the linear polymer is a polymer obtained by a reaction of two diepoxy group-containing compounds (A), one having the structure of Formula (1) and the other having the structure of Formula (2), with a dicarboxyl group-containing compound (B) having a structure of Formula (3); or
the linear polymer is a polymer obtained by a reaction of a diepoxy group-containing compound (A) having a structure of Formula (1) with two dicarboxyl group-containing compounds (B), one having the structure of Formula (2), and the other having the structure of Formula (3).

US Pat. No. 10,113,078

INK DISCHARGE DEVICE AND INK DISCHARGE METHOD

Ricoh Company, Ltd., Tok...

1. An ink discharge device comprising:an ink comprising:
water;
a colorant;
an organic solvent X having a solubility parameter of from 8.9 to 12.0, the organic solvent X comprising no glycol ether compound; and
a copolymer comprising a structural unit represented by the following formula (1):

where R1 represents a hydrogen atom or methyl group and Y represents an alkylene group having 2 to 18 carbon atoms;
an ink discharge head including:
a nozzle configured to discharge the ink;
a plurality of individual liquid chambers in communication with the nozzle;
a flow-in channel configured to let the ink flow into the individual liquid chambers; and
a flow-out channel configured to let the ink flow out from the individual liquid chambers; and
a negative pressure generator configured to generate a negative pressure that lets the ink flow out from the individual liquid chambers,
wherein the ink discharge head is configured to let the ink having flowed out from the flow-out channel flow into the flow-in channel to circulate the ink.

US Pat. No. 10,113,074

THERMALLY INKJETTABLE ACRYLIC DIELECTRIC INK FORMULATION AND PROCESS

FUNAI ELECTRIC CO., LTD.,...

1. An electronic device that comprises a dielectric layer, the dielectric layer being formed by one or more layers of an aqueous composition comprising:from about 5 to about 20 percent by weight of an acrylic polymeric binder emulsion;
from about 5 to about 30 percent by weight of a humectant;
from about 0 to about 3 percent by weight of a surfactant; and
an aqueous carrier fluid,
wherein the aqueous composition has a viscosity ranging from about 2 to about 6 centipoise,
wherein the dielectric layer has a thickness ranging from about 10 microns to about 40 microns, and
wherein the one or more layers have a glass transition temperature ranging from about 40° C. to about 110° C.

US Pat. No. 10,113,073

DIELECTRIC THICK FILM INK

GM GLOBAL TECHNOLOGY OPER...

1. A thermally conductive thick film dielectric ink for an electronic device, the thermally conductive thick film dielectric ink comprising a mixture of:an organic medium present in an amount from about 14.0 to about 32.0% by weight of the thick film dielectric ink, wherein the organic medium comprises 2,2,4-trimethyl-1,3-pentanediol present in an amount from about 81.0% to about 82.0% by weight of the organic medium, Diethylene Glycol Dibutyl Ether present in an amount from about 7.0% to about 11.0% by weight of the organic medium, Dodecyl Alcohol present in an amount about 2.0% by weight of the organic medium, Tridecyl Alcohol present in an amount from about 1.0% to about 4.0% by weight of the organic medium, and Ethyl Cellulose present in an amount from about 3.0 to about 6.5% by weight of the organic medium;
a glass binder; and
a technical ceramic powder having ceramic particles dispersed throughout the thermally conductive thick film dielectric ink mixture.

US Pat. No. 10,113,070

PRETREATMENT COMPOSITIONS AND METHODS OF TREATING A SUBSTRATE

PPG industries Ohio, Inc....

1. A pretreatment composition for treating a metal substrate, comprising:(a) a Group IIIB metal and/or a Group IVB metal present in a total amount of 20 ppm to 1000 ppm (calculated as elemental metal) based on the total weight of the pretreatment composition;
(b) a compound containing at least six phosphorus-containing acid groups or salts thereof present in an amount of 1.82×10?4 moles per liter to 2.73×10?2 moles per liter of pretreatment composition; and
(c) an electropositive metal;
wherein the molar ratio of (a) to (b) is at least 3:1;
wherein the pretreatment composition is capable of reacting with and chemically altering the substrate surface and binding to it to form a film that affords corrosion protection.

US Pat. No. 10,113,065

TWO-PHOTON ABSORBING COMPOUNDS AND METHODS OF MAKING SAME

1. A two-photon active compound having a structural formula:wherein A is an aromatic-heterocyclic ?-electron acceptor moiety that is connected to m number of diarylaminofluorene arms (m=1-3); in each diarylaminofluorene arms, R is selected from linear or branched alkyl chains having a general formula CnH2n+1, where n is in a range from 2 to 25; wherein R1, R2, and R3 are independently selected from the group consisting of H and C1-C5 alkyls; wherein R4 is selected from the group consisting of C1-C5 alkyls; and wherein R5 through R10 are independently selected from the group consisting of H, alkoxyls, alkyls, and aryls.

US Pat. No. 10,113,053

ISOSORBIDE EPOXIDE DIESTERS, AND THE USE THEREOF AS A PLASTICIZER IN PVC COMPOSITIONS

ROQUETTE FRERES, Lestrem...

1. A compound of the following formula (I):

US Pat. No. 10,113,052

5H-FURAN-2-ONE DERIVATIVES STABILIZATION OF ORGANIC MATERIAL

BASF SE, Ludwigshafen (D...

1. A composition comprisinga) a polyolefin, a polyester polyol, or a polyurethane;
b) compound having a structure,

 and
c) an additive selected from the group consisting of a phosphite, a phosphonite, an acid scavenger, a phenolic antioxidant, and an aminic antioxidant.

US Pat. No. 10,113,040

POLYMER FILM, POLARIZING PLATE AND LIQUID CRYSTAL DISPLAY DEVICE

FUJIFILM CORPORATION, To...

1. A polymer film, which comprises:a carbonyl bond-containing polymer; and
a compound having ?h of equal to or higher than 11.0 and ?? of equal to or lower than 1.50, wherein the ?h is a value of hydrogen-bonding capacity calculated by Hoy method and the ?? is a value calculated by equation 1:
??=|x?13.3|   Equation 1
wherein, in equation 1, ? represents an interatomic distance in the polymer film between atoms most distant from each other among molecules in the compound, excluding a hydrogen atom, calculated by molecular dynamics calculation,
wherein said compound is represented by a compound selected from the group:
i) formula (I-1):
(Q3-(L32-L31)n3-A-(L41-L42)n4)m-Z1
wherein each of L31 and L41 independently represents an alkylene group, and the alkylene group may be substituented, each of L32 and L42 independently represents a single bond, or any one of or any combination of —O—, —NR1—, —S— and —C(?O)—, R1 represents a hydrogen atom or a substituent, each of n3 and n4 independently represents an integer of 0 to 20, either n3 or n4 is an integer equal to or higher than 1, and when L31, L32, L41 and L42 exist in plural number, they may be the same as or different from each other, Q3 represents a substituent, Z1 represents an m-valent linking group, and A represents *—O—C(?O)—NH— or *—NH—C(?O)—O—, where * represents a bonding position with L41, m represents an integer of 2 to 6, and Q3 and A existing in plural number may be the same as or different from each other, respectively, and at least one of Q3 and Z1 contains a ring structure,
wherein Z1 is

*—CH2-CH(-*)—CH2-* is formula

*—CH2-C(CH3)(CH2-*)—CH2-* is formula
or*—CH2-CH(C2H5)(CH2-*)—CH2-* is formula

ii) formula (I-3):

wherein each of L71 and L81 independently represents an alkylene group, and the alkylene group may be substituented, each of L72 and L82 independently represents a single bond or any one of or any combination of —O—, —NR1—, —S— and —C(?O), R1 represents a hydrogen atom or a substituent, each of n7 and n8 independently represents an integer of 0 to 12, either n7 or n8 is an integer equal to or higher than 1, and when L71, L72, L81 and L82 exist in plural number, they may be the same as or different from each other, Q5 represent a substituted or an unsubstituted phenyl group, a substituted or unsubstituted cyclohexyl group, a methyl group, an ethyl group, a propyl group, an isopropyl group or a t-butyl group, A represents *—O—C(?O)—NH— or *—NH—C(?O)—O—, where * represents a bonding position with L81, and R2a represents an alkyl group having 1 to 3 carbon atoms, m2 represents an integer of 2 or 3, and Q5 and A existing in plural number may be the same as or different from each other, respectively, a represents an integer of 0 to 10, and, when a is an integer equal to or higher than 1, R2a existing in plural number may be the same as or different from each other;
iii) formula (I-5):

wherein each of L71 and L81 independently represents an alkylene group, and the alkylene group may be substituented, each of L72 and L82 independently represents a single bond or any one of or any combination of —O—, —NR1—, —S— and —C(?O), each of n7 and n8 independently represents an integer of 0 to 12, either n7 or n8 is an integer equal to or higher than 1, and when L71, L72, L81 and L82 exist in plural number, they may be the same as or different from each other, Q5 represent a substituted or an unsubstituted phenyl group, a substituted or unsubstituted cyclohexyl group, a methyl group, an ethyl group, a propyl group, an isopropyl group or a t-butyl group, A represents *—O—C(?O)—NH— or *—NH—C(?O)—O—, where * represents a bonding position with L81, Q5 and A existing in plural number may be the same as or different from each other, respectively, m3 represents 1 or 2, and each of R3 and R4 independently represents a hydrogen atom or a methyl group;
iv) formula (II):

wherein in formula (II) each of L1a and L1b independently represents a single bond, an alkylene group, or a group represented by any of the above-described formulas (2A) to (2E), or a group consisting of a combination of a group represented by any of formulas (2A) to (2E) and two or three alkylene groups, and each of Q1a and Q1b independently represents a substituent, at least one of Q1a and Q1b represents a phenyl group which may have been substituted by an alkyl group having 1 to 3 carbon atoms or an alkoxy group having 1 to 3 carbon atoms;
v) formula (III):

wherein in formula (III) each of L1a and L1b independently represents a single bond, an alkylene group, or a group represented by any of the above-described formulas (2A) to (2E), or a group consisting of a combination of a group represented by any of formulas (2A) to (2E) and two or three alkylene groups, and each of Q1a and Q1b independently represents a substituent, at least one of Q1a and Q1b represents a phenyl group which may have been substituted by an alkyl group having 1 to 3 carbon atoms or an alkoxy group having 1 to 3 carbon atoms;
vi) formula (A):
QA-La1-X—C(?O)—NH-La2-QB
wherein X represents —NR—, and R represents a hydrogen atom or a substituent, each of La1 and La2 independently represents a single bond, or any one of or any combination of an alkylene group, an arylene group, —O—, —NR1—, —S— and —C(?O)—, R1 represents a hydrogen atom or a substituent, each of QA and QB independently represents a substituent, and at least one of QA and QB represents a polar group being a residue of a compound having a C log P value equal to or lower than 0.85, or a terminal group contained in the substituent.

US Pat. No. 10,113,034

POLYMERS FROM STABILIZED IMINES

International Business Ma...

1. A method for producing a polymer, comprising:forming a reaction mixture comprising a non-polar solvent and an imine compound comprising electron withdrawing or accepting groups;
adding a multifunctional nucleophile to the mixture; and
heating the mixture at a temperature from about 50° C. to about 150° C. to produce a polymer.

US Pat. No. 10,113,031

AROMATIC DISPERSANT COMPOSITION

1. A polymer represented by Formula (1):
wherein dispersant of Formula (1) has a terminal and/or pendant imide group, wherein the side chain imide group is derived from an imide compound represented by Formula (1a):

wherein
R1 is a substituent on Q ring in any position available for bonding to a substituent group and R1 is independently represented by one or more of —H, or an electron withdrawing group selected from the group of: —NO2, —SO2NR?2, —C(O)R?, —SO3M, halo, —NH2, and —OR? or an electron releasing alkyl group, a is the total number of sites on the Q ring available for bonding a H, electron withdrawing groups, and electron releasing groups, when R1 is said electron withdrawing group or said alkyl group, then the total number of electron withdrawing and alkyl groups is 1 or 2; M is H, a metal cation, NR?4+, or mixtures thereof; R? is —H, an optionally-substituted alkyl containing 1 to 20 carbon atoms, and the substituent is hydroxyl or halo or mixtures thereof;
Q is a fused or non-fused aromatic ring containing 4n+2 ?-electrons, wherein n=1 or more, and Q is bonded to the imide group in such a way to form a 5 or 6 membered imide ring;
R2 is a C1 to C20 hydrocarbylene group or mixtures thereof; R2 optionally includes oxygen and/or nitrogen atoms wherein there is at least 2 carbon atoms per every oxygen or nitrogen of R2 these would include ether, ester, and amide type linkages in R2;
Pol is a residue of a diepoxide or polyepoxide further comprising at least one pendant side chain of one or more of:
a polyether,
a polyester,
a mixed polyether/polyester pendant side chains thereof,
a mixed polyester/polyether pendant side chains thereof,
or mixtures thereof,
the bond(s) between Pol and each W? allows for one or more terminal and/or pendant side chain imide groups (as defined by w) to be attached to Pol at one or more locations on Pol and for each imide group to be attached to Pol by one or more bond (as defined by b);
W is any group capable of reaction with an epoxide group;
W? represents amino, carboxylic acid and hydroxyl with the H missing and is a residue of the reaction of an amino, hydroxyl or carboxyl group, with a diepoxide or polyepoxide in a reaction forming a chemical bond between an amino, hydroxy, or carboxyl group with an epoxide; when b is 2 then one of the W? is derived from a secondary amine reacted with said epoxide and optionally is in the R2 linking group between the imide and the other W? group, when b is 2 each W? group is the same or different;
b is 1 or 2 and when b is 1, the imide group can either be terminal and attached to the Pol by one chemical bond when W is hydroxyl or carboxylic acid, or a pendant side chain when W is NH2 and when b is 2 the imide group is a side chain attached to Pol by two chemical bonds;
d is 1, 2, or 3; this means that there is the possibility of 1 to 3 imide groups attached to R2 at different carbon atoms of R2; and
w is 1 or more.

US Pat. No. 10,113,030

RESIST MATERIAL AND PATTERN FORMING METHOD USING SAME

Toshiba Memory Corporatio...

1. A pattern forming method comprising:providing, on a substrate, a resist material which comprises a diluent monomer having a hydroxyl group and at least one functional group selected from a vinyl ether group, an epoxy group and an oxetanyl group, a dendrimer with a globular structure having at least two reactive groups for photo-cationic polymerization, and a photo-acid generator as a polymerization initiator;
imprinting a template having concave-convex shape patterns against the resist material;
curing the resist material; and
releasing the template from the cured resist material.

US Pat. No. 10,113,028

EPOXY RESIN, CURABLE RESIN COMPOSITION, CURED PRODUCT, SEMICONDUCTOR ENCAPSULATING MATERIAL, SEMICONDUCTOR DEVICE, PREPREG, CIRCUIT BOARD, BUILDUP FILM, BUILDUP SUBSTRATE, FIBER-REINFORCED COMPOSITE MATERIAL AND FIBER-REINFORCED MOLDED ARTICLE

DIC Corporation, Tokyo (...

1. An epoxy resin, comprising as essential components, a cresol-naphthol co-condensed novolac epoxy resin (A), a naphthol glycidyl ether compound (B), and one or more xanthene compounds (C) selected from the group of compounds represented by the following structural formulae (1) to (3), wherein the content of the xanthene compound(s) (C) is from 0.1% to 5.5% in terms of area ratio in a GPC measurement:wherein in the structural formulae (1) to (3), R? each independently represent a hydrogen atom, an alkyl group having 1 to 4 carbon atoms, or an alkoxy group having 1 to 4 carbon atoms, m each independently represents an integer of 1 to 6,wherein the content of the glycidyl ether compound (B) is from 0.1% to 4.0% in terms of area ratio in a GPC measurement.

US Pat. No. 10,113,019

METHODS OF CHANGING POLYOLEFIN PRODUCTION CONDITIONS TO MITIGATE SMALL GELS IN A POLYOLEFIN ARTICLE

Univation Technologies, L...

1. A method comprising:contacting in a fluidized bed gas phase reactor an olefin monomer with a catalyst system in the presence of an induced condensing agent (ICA) and optionally hydrogen to produce a first polyolefin having a first melt index;
increasing by 10% or less (1) a concentration of the ICA in the reactor, (2) a residence time of the first polyolefin in the reactor, or (3) both to produce a second polyolefin having a second melt index, wherein the second melt index is within 10% of the first melt index; and
wherein a first thin film formed of the first polyolefin has a larger count of a small gel than a second thin film formed of the second polyolefin, wherein the first and second thin film are produced by a same procedure, and wherein the small gel is a gel particle having a diameter of 201 microns to 600 microns and counting the small gel is determined by surface inspection of a 50 micron ±5 micron thin film using optoelectronic analysis.

US Pat. No. 10,113,008

STARCH SETTLING RECOVERY SYSTEM

1. A process consisting essentially of:a. obtaining a waste water stream having starch content between 0.1 and 5% by weight starch and feeding the waste water stream to a classifier to concentrate the slurry by a factor of at least 5 and produce a concentrated slurry, wherein the classifier has at least one overflow exit and at least one underflow exit;
b. drawing off the overflow and underflow from the classifier;
c. feeding the concentrated slurry from the underflow exit of the classifier into a settling tank having at least one settling tank underflow exit and at least one settling tank overflow exit, to produce a settling tank underflow layer of starch with a concentration of between 40 and 60% starch, the settling tank underflow layer being proximate to the settling tank's underflow exit and an aqueous settling tank overflow layer having a starch concentration of less than 5% by weight starch proximate to the settling tank overflow exit,
d. allowing the settling tank underflow layer to exit through the settling tank underflow exit as a starch cake having moisture content between 40 and 60%; and
e. collecting the starch cake for shipping.

US Pat. No. 10,112,976

PROCESS FOR THE PRODUCTION OF D-ARGINYL-2,6-DIMETHYL-L-TYROSYL-L-LYSYL-L-PHENYLALANINAMIDE

1. A liquid-phase process for the production of H-D-Arg-(2,6-Dimethyl)Tyr-Lys-Phe-NH2 of formula (I), in the form of the trifluoroacetic acid salt,
which comprises the following steps:
coupling compound (II) H-Phe-NH2:

with compound (III) Z-Lys(Boc)-OH:

to obtain a compound of formula (IV), Z-Lys-Lys(Boc)-Phe-NH2:

reacting compound (IV) with hydrogen and methanesulfonic acid (V)
MeSO3H  (V)
in the presence of a catalyst to obtain the free amine salt (VI) MeSO3H.H-Lys(Boc)-Phe-NH2:

reacting salt (VI) with the protected amino acid Z-Dmt(Boc)-OH (VII)

to obtain the protected tripeptide Z-Dmt(Boc)-Lys(Boc)-Phe-NH2 (VIII):

treating compound (VIII) with hydrogen and methanesulfonic acid (V) to obtain the corresponding salt MeSO3.H-Dmt(Boc)-Lys(Boc)-Phe-NH2 (IX):

coupling the acid salt (IX) with Z-D-Arg-ONa (X)

to form the protected tetrapeptide Boc-D-Arg-Dmt(Boc)-Lys(Boc)-Phe-NH2 (XI):

deprotecting compound (XI) to obtain the tetrapeptide H-D-Arg-Dmt-Lys-Phe-NH2 (I) and further salifying it with trifluoroacetic acid in solvents.

US Pat. No. 10,112,973

PROCESS FOR THE PREPARATION OF RAMIPRIL

SANOFI-AVENTIS DEUTSCHLAN...

1. A process for preparing a compound of formula (VI)
wherein:
R1 is CO2R4 or CN;
R2 is (C1-C4)alkyl;
R3 is
(C1-C4)alkyl, wherein one, two or three hydrogen atoms are optionally replaced by fluorine, (C1-C4)alkoxy, or
phenyl;
R4 is (C1-C4)alkyl; and
Ar is
phenyl, optionally substituted with one, two or three substituents independently selected from the group consisting of halogen, (C1-C4)alkoxy and (C1-C4)alkyl, or
1-naphthyl;
comprising
reacting a chiral amine of formula (IV)

wherein:
R1 is CO2R4 or CN;
R4 is (C1-C4)alkyl; and
Ar is
phenyl, optionally substituted with one, two or three substituents independently selected from the group consisting of halogen, (C1-C4)alkoxy and (C1-C4)alkyl, or
1-naphthyl;
with a 2-acylamino-acrylic acid ester of formula (V)

wherein:
R2 is (C1-C4)alkyl; and
R3 is
(C1-C4)alkyl, wherein one, two or three hydrogen atoms are optionally replaced by fluorine, (C1-C4)alkoxy, or
phenyl,
to produce the compound of formula (VI).

US Pat. No. 10,112,969

COMPOSITIONS AND METHODS FOR SEQUENCING NUCLEIC ACIDS

INDUSTRIAL TECHNOLOGY RES...

1. A compound having Formula I:
or a pharmaceutically acceptable salt or hydrate thereof, wherein
n is 1, 2, 3, 4, 5, 6, 7, 8, or 9;
i) R1 and each R2 are O?; or
ii) R1 is

 and each R2 is O?; or
iii) R1 is O?, one R2 is

 and any remaining R2 is independently O?, S?, BH3?, or CH3;
R3 is a nucleotide moiety comprising a fluorescent dye F and at least one non-complementary nucleotide residue;
R4 is H, OH, halogen, alkyl (both substituted and unsubstituted), or alkoxy (both substituted and unsubstituted);
Y1, and Y3 are each independently chosen from O?, S?, BH3?, and CH3;
L1 is chosen from alkyl, alkenyl, alkynyl, aryl, heteroaryl, heterocyclyl, ester, amino, and sulfonyl;
Q is a fluorescence quenching moiety; and
B1 is chosen from adenine, cytosine, guanine, thymine, uracil, hypoxanthine, and 5-methylcytosine.

US Pat. No. 10,112,964

DITHIOLENE METAL COMPLEX COLORLESS IR ABSORBERS

BASF SE, Ludwigshafen (D...

1. A method of using colorless IR absorbers comprisinga) treating a material with a compound from the group consisting of

wherein the material is a security print, an invisible and IR readable bar code,
a laser-welded plastic, a dried print, a fixed toner on paper, a laser marked plastic, or a heated preform,
optionally a further IR absorber; and
b) using the treated material of a) for security printing, invisible and IR readable bar codes, laser-welding of plastics, drying of print, fixing of toners on paper, laser marking, and heating of plastics preforms.

US Pat. No. 10,112,962

BORON-BASED PRODRUG STRATEGY FOR INCREASED BIOAVAILABILITY AND LOWER-DOSAGE REQUIREMENTS FOR DRUG MOLECULES CONTAINING AT LEAST ONE PHENOL (OR AROMATIC HYDROXYL) GROUP

XAVIER UNIVERSITY, New O...

1. A compound of Formula 29:
wherein R is selected from the group consisting of:

 KF3B; (HO)2B; and NaF3B; and
wherein the boron atom is the point of attachment in each R variable substituent, and any salts thereof.

US Pat. No. 10,112,960

METHODS FOR PRODUCING BORYLATED ARENES

Dow AgroSciences LLC, In...

1. A method of forming a borylated arene comprising:providing a substrate comprising a substituted arene ring comprising from 1 to 4 substituents, wherein the arene ring is unsubstituted at a first position that is electronically favored for CH-activation and unsubstituted at a second position that is sterically favored for CH-activation; and
contacting the substrate with an iridium precursor complex, an electron deficient bidentate ligand comprising at least one nitrogen heteroatom, and a borylation reagent under conditions effective to form a first borylated arene and optionally a second borylated arene;
wherein the electron deficient bidentate ligand comprises a compound defined by Formula IVa

wherein n is 0, 1, 2, or 3 and R10 is, independently for each occurrence, hydrogen, a halogen, a nitrile group, a nitro group, a C1-C6 alkyl group, or a C1-C6 perfluoroalkyl group, with the proviso that at least one of R10 is chosen from a halogen, a nitrile group, a nitro group, and a C1-C6 perfluoroalkyl group;
wherein the first borylated arene comprises a substituted arene ring comprising from 1 to 4 substituents and a boronic acid or a boronic acid derivative in the first position,
wherein the second borylated arene, when formed, comprises a substituted arene ring comprising from 1 to 4 substituents and a boronic acid or a boronic acid derivative in the second position, and
wherein the molar ratio of the first borylated arene to the second borylated arene is at least 1:1, as determined by GC-FID.

US Pat. No. 10,112,959

METAL COMPLEX AND COLOR CONVERSION FILM COMPRISING SAME

LG CHEM, LTD., Seoul (KR...

1. A compound of the following Chemical Formula 1:
wherein, in Chemical Formula 1,
at least one of R1 to R5 is selected from among the following structural formulae;

R6 is hydrogen; a nitrile group; a substituted or unsubstituted alkyl group; a substituted or unsubstituted cycloalkyl group; a substituted or unsubstituted alkoxy group; a substituted or unsubstituted aryl group; a substituted or unsubstituted alkylaryl group; or a substituted or unsubstituted aromatic or aliphatic heterocyclic group;
X1 and X2 are the same as or different from each other, and each independently F; a nitrile group; a substituted or unsubstituted alkynyl group; a substituted or unsubstituted alkyl group; a substituted or unsubstituted alkoxy group; a substituted or unsubstituted aryloxy group; a substituted or unsubstituted arylalkoxy group; a substituted or unsubstituted aryl group; or a substituted or unsubstituted aromatic or aliphatic heterocyclic group, or bond to each other to form an aromatic or aliphatic ring;
X3 is a halogen group; a nitrile group; a carbonyl group; an ester group; an amide group; a sulfonate group; a substituted or unsubstituted alkyl group; a fluoroalkyl group; a substituted or unsubstituted cycloalkyl group; a substituted or unsubstituted alkoxy group; a substituted or unsubstituted alkylsulfoxy group; a substituted or unsubstituted silyl group; a substituted or unsubstituted phosphine oxide group; or a substituted or unsubstituted alkylaryl group;
Y1 is CR101 or N, Y2 is CR102 or N, Y3 is CR103 or N and Y4 is CR104 or N; and
groups of R1 to R5 that are not the above-mentioned structural formulae, R8 to R13 and R101 to R104 are the same as or different from each other, and each independently hydrogen; deuterium; a halogen group; a nitrile group; a nitro group; a carbonyl group; an ester group; an imide group; an amide group; a sulfonate group; a substituted or unsubstituted alkyl group; a substituted or unsubstituted cycloalkyl group; a substituted or unsubstituted alkoxy group; a substituted or unsubstituted aryloxy group; a substituted or unsubstituted alkylthioxy group; a substituted or unsubstituted arylthioxy group; a substituted or unsubstituted alkylsulfoxy group; a substituted or unsubstituted arylsulfoxy group; a substituted or unsubstituted alkenyl group; a substituted or unsubstituted silyl group; a substituted or unsubstituted boron group; a substituted or unsubstituted arylphosphine group; a substituted or unsubstituted phosphine oxide group; a substituted or unsubstituted arylalkyl group; a substituted or unsubstituted alkylaryl group; a substituted or unsubstituted aryl group; or a substituted or unsubstituted aromatic or aliphatic heterocyclic group, and R9 and R10 bond to each other to form an aliphatic or aromatic ring, and R12 and R13 bond to each other to form an aliphatic or aromatic ring.

US Pat. No. 10,112,958

N-[2-(2-AMINO-6,6-DISUBSTITUTED-4,4A,5,6-TETRAHYDROPYRANO[3,4-D][1,3]THIAZIN-8A(8H)-YL)-1,3-THIAZOL-4-YL] AMIDES

Pfizer Inc., New York, N...

1. A compound of Formula IwhereinR1 is selected from the group consisting of:
C1-6alkyl optionally substituted with one to three fluoro or C1-3alkoxy;
C5-9bicycloalkyl optionally substituted with one to three R4; and
a 5- to 6-membered heteroaryl, having one to four heteroatoms independently selected from N, O or S, wherein at least one of the heteroatoms is N and wherein said N is optionally substituted with R5; and wherein said 5- to 6-membered heteroaryl is optionally substituted on carbon with one to three R4;
R2 and R3 are each independently selected from C1-6alkyl or C3-7cycloalkyl; wherein the C1-6alkyl is optionally substituted with one to three fluoro or C1-3alkoxy; or R2 and R3 taken together with the carbon to which they are attached form a C3-6cycloalkyl ring or a 4- to 6-membered heterocycloalkyl ring, each of which is optionally and independently substituted with one to three fluoro, C1-3alkyl or C1-3alkoxy;
R4 at each occurrence is independently selected from the group consisting of halogen, hydroxy, cyano, C1-6alkyl, C1-6alkoxy, C3-6alkenyl, C3-6alkenyloxy, C3-6alkynyl, C3-6alkynyloxy, C1-6alkoxy-C1-6alkyl, C3-6cycloalkoxy, C3-6cycloalkyl, C3-6cycloalkyl-C1-6alkyl, C3-6cycloalkyl-C1-6alkoxy, 4- to 6-membered heterocycloalkyl and 4- to 6-membered heterocycloalkyl-C1-6alkyl; wherein said C1-6alkyl, C1-6alkoxy, C3-6alkenyl, C3-6alkenyloxy, C3-6alkynyl, C3-6alkynyloxy, C1-6alkoxy-C1-6alkyl, C3-6 cycloalkoxy, C3-6cycloalkyl, C3-6cycloalkyl-C1-6alkyl, C3-6cycloalkyl-C1-6alkoxy, 4- to 6-membered heterocycloalkyl and 4- to 6-membered heterocycloalkyl-C1-6alkyl are each optionally substituted with one to three substituents independently selected from fluoro, chloro, hydroxy, cyano, methyl, fluoromethyl, difluoromethyl, trifluoromethyl, methoxy, fluoromethoxy, difluoromethoxy and trifluoromethoxy; and
R5 is hydrogen, C1-6alkyl, C3-6alkenyl, C3-6alkynyl, C1-6alkoxy-C1-6alkyl, C3-6cycloalkyl, C3-6cycloalkyl-C1-6alkyl, 4- to 6-membered heterocycloalkyl and 4- to 6 membered heterocycloalkyl-C1-6alkyl; wherein said C1-6alkyl, C3-6alkenyl, C3-6alkynyl, C1-6alkoxy-C1-6alkyl, C3-6cycloalkyl, C3-6cycloalkyl-C1-6alkyl, 4- to 6-membered heterocycloalkyl and 4-to 6-membered heterocycloalkyl-C1-6alkyl are each optionally substituted with one to three substituents independently selected from fluoro, chloro, hydroxy, cyano, methyl, fluoromethyl, difluoromethyl, trifluoromethyl, methoxy, fluoromethoxy, difluoromethoxy and trifluoromethoxy; or R4 and R5 taken together can be a C3-5alkylene;
or a tautomer thereof or a pharmaceutically acceptable salt of said compound or tautomer.

US Pat. No. 10,112,954

BICYCLIC HETEROARYL DERIVATIVES HAVING INHIBITORY ACTIVITY FOR PROTEIN KINASE

HANMI PHARM. CO., LTD., ...

7. A pharmaceutical composition comprising the compound of claim 1 as an active ingredient and a pharmaceutically acceptable carrier.

US Pat. No. 10,112,951

PDE1 INHIBITOR

Eli Lilly and Company, I...

1. A method of treating chronic kidney disease in a patient, comprising administering to a patient in need thereof an effective amount of a compound of the formula:

US Pat. No. 10,112,947

SUBSTITUTED 6-AMINOPURINES FOR TARGETING HSP90

Duke University, Durham,...

1. A compound of formula (I):wherein:A is a heat shock protein 90 binding component of formula (III):

wherein:
R is alkylenyl or heteroalkylenyl;
each Y1 is independently —CH or —N;
each Z1 is taken together with the carbon atoms to which they are attached to form a heterocyclic ring;
Z2 is —H or halo;
Z3 is —CH2—, —S—, —O—or —NH—;
Z4 is —H or halo; and
is the point of attachment in formula (I);X1 is —NH—, —O—, —S—, —C(O)—or —S(O)2—;
L is a divalent linker of the following formula:
—(CH2)m—(OCH2CH2)n—O—(CH2)p—,
wherein:
m is 2 or 3;
n is 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19 or 20; and
p is 2 or 3;
X2 is —NR—, —O—, —S—, —C(O)—or —S(O)2—;
R is —H or a detection moiety; and
B is a detection moiety, an anti-cancer agent, or a heat shock protein 90 binding component of formula (II):

wherein:
R1 is —H or —C1-8-alkyl;
R2 is —H or —C1-8-alkyl;
Y is —CR3 or —N;
R3 is —H, —F or —OCH3;
R4 is —H, —F or —OCH3;
R5 is —H, —F or —OCH3;
R6 is —C1-8-alkyl, —C2-8-alkenyl, —C2-8-alkynyl, —C3-8-cycloalkenyl, —C3-8-cycloalkenyl-C1-8-alkyl, —C3-8-cycloalkyl, —C3-8-cycloalkyl-C1-8-alkyl, aryl, aryl-C1-8-alkyl, halo-C1-8-alkyl, heteroaryl, heteroaryl-C1-8-alkyl, heterocyclyl, heterocyclyl-C1-8-alkyl, or hydroxy-C1-8-alkyl;
R7 is —H or —C1-8-alkyl;
R8 is —H or —C1-8-alkyl; or
R7 and R8, taken together with the carbon atom to which they are attached, form a —C3-8-cycloalkyl;
X is —CR9 or —N;
R9 is —H or —C1-8-alkyl; and
is the point of attachment in formula (I); orB is a detection moiety, an anti-cancer agent, or a heat shock protein 90 binding component of formula (III):

wherein:
R is alkylenyl or heteroalkylenyl;
each Y1 is independently —CH or —N;
each Z1 is taken together with the carbon atoms to which they are attached to form a heterocyclic ring;
Z2 is —H or halo;
Z3 is —CH2—, —S—, —0—or —NH—;
Z4 is —H or halo; and
is the point of attachment in formula (I);wherein each detection moiety independently comprises a fluorophore or a radioactive compound;
wherein the fluorophore is a fluorescein, a rhodamine, a coumarin, a cyanine or a boron-dipyrromethene;
wherein the radioactive compound is a radioisotope; and
wherein the anti-cancer agent is an alkylating agent, an anti-epidermal growth factor receptor antibody, an anti-Her-2 antibody, an antimetabolite, a vinca alkaloid, an anthracycline, a platinum-based agent, a topoisomerase inhibitor, a taxane, an anti-cancer antibiotic, an immune cell antibody, an interferon, an interleukin, a heat shock protein 90 inhibitor, an anti-androgen, an anti-estrogen, an antihypercalcemia agent, an apoptosis inducer, an aurora kinase inhibitor, a Bruton's tyrosine kinase inhibitor, a calcineurin inhibitor, a Ca2+-calmodulin-dependent protein kinase II inhibitor, a CD45 tyrosine phosphatase inhibitor, a cell division cycle 25 phosphatase inhibitor, a checkpoint kinase inhibitor, a cyclooxygenase inhibitor, a cRAF kinase inhibitor, a cyclin dependent kinase inhibitor, a cysteine protease inhibitor, a deoxyribonucleic acid intercalator, a deoxyribonucleic acid strand breaker, an E3 ligase inhibitor, an epidermal growth factor pathway inhibitor, a farnesyltransferase inhibitor, a fetal liver kinase-1 inhibitor, a glycogen synthase kinase-3 inhibitor, a histone deacetylase inhibitor, an I-kappa B-alpha kinase inhibitor, an imidazotetrazinone, an insulin tyrosine kinase inhibitor, a c-Jun N-terminal kinase inhibitor, a mitogen-activated protein kinase inhibitor, a mouse double minute 2 inhibitor, an MEK inhibitor, a matrix metalloproteinase inhibitor, a mammalian target of rapamycin inhibitor, a nerve growth factor receptor tyrosine kinase inhibitor, a p38 mitogen-activated protein kinase inhibitor, a p56 tyrosine kinase inhibitor, a platelet-derived growth factor pathway inhibitor, a phosphatidylinositol 3-kinase inhibitor, a phosphatase inhibitor, a protein phosphatase inhibitor, a protein kinase C inhibitor, a protein kinase C delta kinase inhibitor, a polyamine synthesis inhibitor, a protein tyrosine phosphatase 1B inhibitor, a protein tyrosine kinase inhibitor, an SRC family tyrosine kinase inhibitor, a spleen tyrosine kinase inhibitor, a Janus tyrosine kinase inhibitor, a retinoid, a ribonucleic acid polymerase II elongation inhibitor, a serine/threonine kinase inhibitor, a sterol biosynthesis inhibitor, a vascular endothelial growth factor pathway inhibitor, alitretinon, altretamine, aminopterin, aminolevulinic acid, amsacrine, asparaginase, atrasentan, bexarotene, carboquone, demecolcine, efaproxiral, elsamitrucin, etoglucid, a Gliadel implant, hydroxycarbamide, leucovorin, lonidamine, lucanthone, masoprocol, methyl aminolevulinate, mitoguazone, mitotane, oblimersen, omacetaxine, pegaspargase, porfimer sodium, prednimustine, sitimagene ceradenovec, talaporfin, temoporfin, trabectedin or verteporfin.

US Pat. No. 10,112,945

FUSED QUINOLINE COMPUNDS AS PI3K, MTOR INHIBITORS

1. A compound of formula I
wherein
Q1 and Q2 are independently selected from an aryl, a 5-6 membered heterocyclyl or a 9-11 membered bicycloheterocyclyl;
Z is N or C—R;
R and R1, when present, are independently selected from H, halogen, halogenC1-C6alkyl, —C1-C6alkyl, —OR7, —NR7R8, or are not present;
wherein when R and R1 are not present Q1 is a halogen;
R2 and R3 are independently selected from H, halogen, —OH, —C1-C6alkyl, —C1-C6alkoxyl, —C1-C6alkenyl or —C1-C6alkynyl;
R7 and R8 are independently selected from H, halogen, —C1-C6alkyl, —C1-C6alkylOH, —C1-C6alkoxyl, —C1-C6alkylNR4R5, —C(?O)C1-C6alkyl, —C(?O)C1-C6alkyl-R4R5, —C(?O)C1-C6alkylOH, —C(?O)C1-C6alkoxyl, —C(?O)C1-C6alkylNR4R5, —C(?O)OC1-C6alkyl, —C(?O)OC1-C6alkylOH, —C(?O)OC1-C6alkoxyl, —C(?O)OC1-C6alkylNR4R5, —C(?O)NR4C1-C6alkyl, —C(?O)NR4C1-C6al-kylOH, —C(?O)NR4C1-C6alkoxyl, —C(?O)NR4C1-C6alkylNR4R5;
R4 and R5 are independently selected from H, halogen, halogenC1-C6alkyl, —C1-C6alkyl, —OH, —C1-C6alkoxyl, cycloalkyl; or both R4 and R5 can be combined together to form a 3-8 membered saturated or unsaturated ring that can be aliphatic cyclyl or heterocyclyl;
or a pharmaceutically acceptable salt thereof.

US Pat. No. 10,112,944

HETEROCYCLIC COMPOUNDS USEFUL AS INHIBITORS OF TNF

Bristol-Myers Squibb Comp...

1. A compound of Formula (I)
or a salt thereof, wherein:
X is CR6 or N;
W is:
(i) —(CR3R3)1-4—; or
(ii) —(CR3R3)x—Y—(CR3R3)y—;
each Y is independently O, NR4, or S(O)p;
x is zero, 1, or 2;
y is 1, 2, or 3, provided that (x+y) is 1, 2, or 3;
R1 is C2-6 alkenyl substituted with zero to 6 R1a, C2-6 alkynyl substituted with zero to 4 R1a, —(CRgRg)r(3-14 membered carbocyclyl substituted with zero to 3 R1a), —(CRgRg)r(aryl substituted with zero to 3 R1a), —(CRgRg)r(5-7 membered heterocyclyl substituted with zero to 3 R1a), or —(CRgRg)r(mono- or bicyclic heteroaryl substituted with zero to 3 R1a);
R2 is H, halo, —CN, —CF3, —OCF3, —NO2, C1-6 alkyl substituted with zero to 6 R1a, —(CRgRg)rORe, —(CRgRg)rNRcRc, —(CRgRg)rS(O)pRb, —(CRgRg)r(3-14 membered carbocyclyl substituted with zero to 3 R1a), —(CRgRg)r(aryl substituted with zero to 3 R1a), —(CRgRg)r(5-7 membered heterocyclyl substituted with zero to 3 R1a), or —(CRgRg)r(monocyclic heteroaryl substituted with zero to 3 R1a);
each R3 is independently H, halo, —CN, —OH, —OCF3, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, —(CRgRg)rC(O)Rb, —(CRgRg)rC(O)ORb, —(CRgRg)rC(O)NRcRc, —(CRgRg)rORe, —(CRgRg)rOC(O)Rb, —(CRgRg)rOC(O)NRcRc, —(CRgRg)rOC(O)ORd, —(CRgRg)rNRcRc, —(CRgRg)rNRbC(O)Rd, —(CRgRg)rNRbC(O)ORd, —(CRgRg)rNRbC(O)NRcRc, —(CRgRg)rNRbS(O)pRd, —(CRgRg)rS(O)pRb, —(CRgRg)rS(O)pNRcRc, —(CRgRg)r(3-14 membered carbocyclyl substituted with zero to 3 R1a), —(CRgRg)r(aryl substituted with zero to 3 R1a), —(CRgRg)r(5-7 membered heterocyclyl substituted with zero to 3 R1a), or —(CRgRg)r(mono- or bicyclic heteroaryl substituted with zero to 3 R1a); or two R3 along with the carbon atom to which they are attached form C?O, C?NORb, a spirocarbocyclyl group, or a spiroheterocyclyl group;
each R4 is independently H, C1-6 alkyl substituted with zero to 6 R1a, C3-7 cycloalkyl substituted with zero to 6 R1a, —C(O)Rb, —C(O)NRcRc, —C(O)ORb, —S(O)2Rb, —S(O)2NRcRc, —S(O)2ORb, —(CRgRg)r(3-14 membered carbocyclyl substituted with zero to 3 R1a), —(CRgRg)r(aryl substituted with zero to 3 R1a), —(CRgRg)r(5-7 membered heterocyclyl substituted with zero to 3 R1a), or —(CRgRg)r(monocyclic heteroaryl substituted with zero to 3 R1a);
R5 is —(CRgRg)r(3-14 membered carbocyclyl substituted with zero to 3 R1a), —(CRgRg)r(aryl substituted with zero to 3 R1a), —(CRgRg)r(5-10 membered heterocyclyl substituted with zero to 3 R1a), or —(CRgRg)r(mono- or bicyclic heteroaryl substituted with zero to 3 R1a);
R6 is H, halo, or —CN;
R7 is H, halo, —CN, C1-6 alkyl, or C1-3 alkoxy;
each R1a is independently F, Cl, —CN, C1-6 alkyl substituted with zero to 6 Ra, C3-6 cycloalkyl substituted with zero to 6 Ra, C1-3 alkoxy substituted with zero to 6 Ra, C1-3 haloalkoxy, heterocycloalkyl substituted with zero to 6 Ra, aryl substituted with zero to 6 Ra, mono- or bicyclic heteroaryl substituted with zero to 6 Ra, —C(O)Rb, —C(O)ORb, —C(O)NRcRc, —OC(O)Rb, —OC(O)NRcRc, —OC(O)ORd, —NRcRc, —NRbC(O)Rd, —NRbC(O)ORd, —NRbS(O)pRd, —NRbC(O)NRcRc, —NRbS(O)pNRcRc, —S(O)pRb, —S(O)pNRcRc, or —C(O)NRb(CH2)1-3NRcRc;
each Ra is independently halo, —CN, —OH, —NH2, C1-3 alkyl, C1-3 fluoroalkyl, C2-4 alkenyl, C2-4 alkynyl, C1-3 alkoxy, C1-3 fluoroalkoxy, —C(O)OH, —C(O)(C1-3 alkyl), —C(O)O(C1-4 alkyl), —OC(O)(C1-3 alkyl), —NH(C1-3 alkyl), —N(C1-3 alkyl)2, —C(O)NH(C1-3 alkyl), —OC(O)NH(C1-3 alkyl), —NHC(O)NH(C1-3 alkyl), —C(?NH)(NH2), C3-7 carbocyclyl, aryl, 5-7 membered heterocyclyl, mono- or bicyclic heteroaryl, —O(aryl), —O(benzyl), —O(heterocyclyl), —S(C1-3 alkyl), —S(aryl), —S(heterocyclyl), —S(O)(aryl), —S(O)(heterocyclyl), —S(O)2(aryl), —S(O)2(heterocyclyl), —NHS(O)2(aryl), —NHS(O)2(heterocyclyl), —NHS(O)2NH(aryl), —NHS(O)2NH(heterocyclyl), —NH(aryl) —NH(heterocyclyl), —NHC(O)(aryl), —NHC(O)(C1-3 alkyl), —NHC(O)(heterocyclyl), —OC(O)(aryl), —OC(O)(heterocyclyl), —NHC(O)NH(aryl), —NHC(O)NH(heterocyclyl), —OC(O)O(C1-3 alkyl), —OC(O)O(aryl), —OC(O)O(heterocyclyl), —OC(O)NH(aryl), —OC(O)NH(heterocyclyl), —NHC(O)O(aryl), —NHC(O)O(heterocyclyl), —NHC(O)O(C1-3 alkyl), —C(O)NH(aryl), —C(O)NH(heterocyclyl), —C(O)O(aryl), —C(O)O(heterocyclyl), —N(C1-3 alkyl)S(O)2(aryl), —N(C1-3 alkyl)S(O)2(heterocyclyl), —N(C1-3 alkyl)S(O)2NH(aryl), —N(C1-3 alkyl)S(O)2NH(heterocyclyl), —N(C1-3 alkyl)(aryl), —N(C1-3 alkyl)(heterocyclyl), —N(C1-3 alkyl)C(O)(aryl), —N(C1-3 alkyl)C(O)(heterocyclyl), —N(C1-3 alkyl)C(O)NH(aryl), —(CH2)0-3C(O)NH(heterocyclyl), —OC(O)N(C1-3 alkyl)(aryl), —OC(O)N(C1-3 alkyl)(heterocyclyl), —N(C1-3 alkyl)C(O)O(aryl), —N(C1-3 alkyl)C(O)O(heterocyclyl), —C(O)N(C1-3 alkyl)(aryl), —C(O)N(C1-3 alkyl)(heterocyclyl), —NHS(O)2N(C1-3 alkyl)(aryl), —NHS(O)2N(C1-3 alkyl)(heterocyclyl), —NHP(O)2N(C1-3 alkyl)(aryl), —NHC(O)N(C1-3 alkyl)(aryl), —NHC(O)N(C1-3 alkyl)(heterocyclyl), —N(C1-3 alkyl)S(O)2N(C1-3 alkyl)(aryl), —N(C1-3 alkyl)S(O)2N(C1-3 alkyl)(heterocyclyl), —N(C1-3 alkyl)C(O)N(C1-3 alkyl)(aryl), —N(C1-3 alkyl)C(O)N(C1-3 alkyl)(heterocyclyl), or —Si(C1-3 alkyl)3;
each Rb is independently H, C1-6 alkyl substituted with zero to 6 Rf, C3-7 cycloalkyl substituted with zero to 6 Rf, heterocycloalkyl substituted with zero to 6 Rf, aryl substituted with zero to 3 Rf, or mono- or bicyclic heteroaryl substituted with zero to 3 Rf;
each Rc is independently H, C1-6 alkyl substituted with zero to 6 Rf, C3-7 cycloalkyl substituted with zero to 6 Rf, heterocycloalkyl substituted with zero to 6 Rf, aryl substituted with zero to 3 Rf, or mono- or bicyclic heteroaryl substituted with zero to 3 Rf; or when attached to the same nitrogen, two Rc along with the nitrogen atom to which they are attached form 4-8 membered heterocyclic ring optionally substituted with Rg;
each Rd is independently H, C1-6 alkyl substituted with zero to 6 Rf, C3-7 cycloalkyl substituted with zero to 6 Rf, heterocycloalkyl substituted with zero to 6 Rf, aryl substituted with zero to 3 Rf, or mono- or bicyclic heteroaryl substituted with zero to 3 Rf;
each Re is independently H, C1-6 alkyl substituted with zero to 6 Rf, C1-3 haloalkyl, C3-7 cycloalkyl substituted with zero to 6 Rf, heterocycloalkyl substituted with zero to 6 Rf, aryl substituted with zero to 3 Rf, or mono- or bicyclic heteroaryl substituted with zero to 3 Rf;
each Rf is independently H, halo, —OH, —CN, C1-6 alkyl substituted with zero to 6 Ra, C1-3 alkoxy, C3-7 cycloalkyl substituted with zero to 6 Ra, heterocycloalkyl substituted with zero to 6 Ra, aryl substituted with zero to 3 Ra, or mono- or bicyclic heteroaryl substituted with zero to 3 Ra;
each Rg is independently H, F, —OH, —CN, C1-3 alkyl, —CF3, or phenyl;
each p is independently zero, 1, or 2; and
each r is independently zero, 1, 2, 3, or 4.

US Pat. No. 10,112,941

TRICYCLIC COMPOUNDS AS ANTICANCER AGENTS

Bristol-Myers Squibb Comp...

1. A method for treating cancer in a subject in need thereof, comprising administering an effective amount of a compound, of the formula
or a pharmaceutically acceptable salt thereof,
in combination with the administration of a therapeutically effective amount of one or more immuno-oncology agents.

US Pat. No. 10,112,940

HISTONE DEMETHYLASE INHIBITORS

Celgene Quanticel Researc...

1. A method of treating a histone demethylase-associated esophageal and breast cancer in a subject comprising administering a therapeutically effective dose of a compound of Formula (IIIa)
wherein the compound of Formula (IIIa) includes pharmaceutically acceptable salts thereof, wherein:
X is halogen and n is 0 or 1;
Y is hydrogen or C1-C3alkyl;
Z is halogen, —OH, —NH2, —CN, —SO2, CF3, alkyl, alkoxy, alkylamino, optionally substituted 3 membered carbocyclyl, optionally substituted 5-7 membered heterocyclyl comprising 1-2 heteroatoms selected from N or O, or 6 membered heteroaryl comprising 1 oxygen; and m is 0, 1, or 2.

US Pat. No. 10,112,939

TIED-BACK BENZAMIDE DERIVATIVES AS POTENT ROCK INHIBITORS

Bristol-Myers Squibb Comp...

1. A compound of formula (IV):
or an enantiomer, a diastereomer, a stereoisomer, or a pharmaceutically acceptable salt thereof,
wherein:
R3 is independently selected from CN, C1-4 alkyl substituted with 0-3 Re, and —ORb;
R8 is independently selected from F, C1-4 alkyl substituted with 0-3 Re, —(CH2)rORb, —(CH2)rC(?O)Rb, —NRaRa, —C(?O)NRaRa, and —C(?O)ORb;
R9 is independently selected from F, Cl, Br, C1-4 alkyl,
nitro, —S(O)pRc, —S(O)pNRaRa, —ORb, —NRaRa, —C(?O)ORb, —(CH2)rC(?O)Rb, —C(?O)NRaRa, —(CH2)r-c ycloalkyl, —(CH2)r-heterocyclyl, —(CH2)r-aryl, and —(CH2)r-heteroaryl, wherein said alkyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl is substituted with 0-4 Re;
Ra, at each occurrence, is independently selected from H, CN, C1-6 alkyl substituted with 0-5 Re, —(CH2)r—C3-6cycloalkyl substituted with 0-5 Re, —(CH2)r-aryl substituted with 0-5 Re, and —(CH2)r-heterocyclyl substituted with 0-5 Re; or Ra and Ra together with the nitrogen atom to which they are both attached form a heterocyclic ring substituted with 0-5 Re;
Rb, at each occurrence, is independently selected from H, C1-6 alkyl substituted with 0-5 Re, C2-6 alkenyl substituted with 0-5 Re, C2-6 alkynyl substituted with 0-5 Re, —(CH2)r—C3-10carbocyclyl substituted with 0-5 Re, and —(CH2)r-heterocyclyl substituted with 0-5 Re;
Rc, at each occurrence, is independently selected from C1-6 alkyl substituted with 0-5 Re, C2-6alkenyl substituted with 0-5 Re, C2-6alkynyl substituted with 0-5 Re, C3-6carbocyclyl, and heterocyclyl;
Re, at each occurrence, is independently selected from C1-6 alkyl substituted with 0-5 Rf, C2-6 alkenyl, C2-6 alkynyl, —(CH2)r—C3-6 cycloalkyl, F, Cl, Br, CN, NO2, ?O, CO2H, —(CH2)rORf, S(O)pRf, S(O)pNRfRf, and —(CH2)rNRfRf;
Rf, at each occurrence, is independently selected from H, F, Cl, Br, CN, OH, C1-5 alkyl, C3-6 cycloalkyl, and phenyl, or Rf and Rf together with the nitrogen atom to which they are both attached form a heterocyclic ring optionally substituted with C1-4alkyl;
p, at each occurrence, is independently selected from zero, 1, and 2; and
r, at each occurrence, is independently selected from zero, 1, 2, 3, and 4;
provided that R3 is not OPh.

US Pat. No. 10,112,937

P2X7 MODULATORS AND METHODS OF USE

Janssen Pharmaceutica NV,...

36. A pharmaceutical composition, comprising:(a) a therapeutically effective amount of at least one compound selected from compounds of Formula (IIa and IIb):

R3, R4 and R6 are independently H or C1-C3 alkyl;
R8 is phenyl or pyridyl, optionally substituted with zero to three Rm substituents wherein Rm is independently selected from the group consisting of: halo, C1-C3alkyl and perhaloalkyl;
R7 is (a) phenyl, optionally substituted with zero to two groups independently selected from the group consisting of halo and C1-C3alkyl, or
(b) heteroaryl, independently selected from the group consisting of:

wherein Rk is halo or C1-C3alkyl;
Rj is H or C1-C3alkyl; wherein C1-C3alkyl is optionally substituted with one halo substituent or one alkoxy substituent; and
n is an integer from 0-3; and
pharmaceutically acceptable salts of compounds of Formula (IIa and IIb); and
(b) at least one pharmaceutically acceptable excipient.

US Pat. No. 10,112,936

FIVE-MEMBERED HETEROCYCLES USEFUL AS SERINE PROTEASE INHIBITORS

Bristol-Myers Squibb Comp...

1. A compound of Formula (V)
or its stereoisomers, tautomers, a pharmaceutically acceptable salts, or solvates thereof, wherein:
A is C3-7 cycloalkyl substituted with 0-1 R1 and 0-2 R2;

Z is —CH(R11)—;
L is —C(O)NH—;
R1 is, independently at each occurrence, —NH2, —NH(C1-3 alkyl), —N(C1-3 alkyl)2, —C(?NH)NH2, —C(O)NR8R9, —S(O)pNR8R9, —(CH2)rNR7R8, —(CH2)rNR7C(O)ORa, —CH2N H2, —CH2NH(C1-3 alkyl), —CH2N(C1-3 alkyl)2, —CH2CH2NH2, —CH2CH2NH(C1-3 alkyl), —CH2CH2N(C1-3 alkyl)2, —CH(C1-4 alkyl)NH2, —C(C1-4 alkyl)2NH2, —C(?NR8a)NR7R8, —NHC(?NR8a)NR7R8, ?NR8, —NR8CR8(?NR8a), F, Cl, Br, I, OCF3, CF3, —(CH2)rORa, —(CH2)rSRa, CN, 1-NH2-1-cyclopropyl, or C1-6 alkyl substituted with 0-1 R1a;
R1a is H, —C(?NR8a)NR7R8, —NHC(?NR8a)NR7R8, —NR8CH(?NR8a), —NR7R8, —C(O)NR8R9, F, OCF3, CF3, ORa, SRa, CN, —NR9SO2NR8R9, —NR8SO2Rc, —S(O)p—C1-4 alkyl, —S(O)p-phenyl, or —(CF2)rCF3;
R2 is, independently at each occurrence, H, ?O, F, Cl, Br, I, OCF3, CF3, CHF2, CN, NO2, ORa, SRa, —C(O)Ra, —C(O)ORa, —OC(O)Ra, —NR7R8, —C(O)NR7R8, —NR7C(O)Rb, —S(O)2NR8R9, —NR8S(O)2Rc, —S(O)2Rc, —S(O)2Rc, C1-6 alkyl substituted with 0-2 R2a, C2-6 alkenyl substituted with 0-2 R2a, C2-6 alkynyl substituted with 0-2 R2a, —(CH2)r-C3-10 carbocycle substituted with 0-3 R2b, or —(CH2)r-5- to 10-membered heterocycle comprising: carbon atoms and 1-4 heteroatoms selected from N, O, and S(O)p, wherein said heterocycle is substituted with 0-3 R2b;
R2a is, independently at each occurrence, H, F, Cl, Br, I, ?O, ?NR8, CN, OCF3, CF3, ORa, SRa, —NR7R8, —C(O)NR8R9, —NR7C(O)Rb, —S(O)pNR8R9, —NR8SO2Rc, —S(O)Rc, or —S(O)2Rc;
R2b is, independently at each occurrence, H, F, C1, Br, I, ?O, ?NR8, CN, NO2, ORa, SRa, —C(O)Ra, —C(O)ORa, —OC(O)Ra, —NR7R8, —C(O)NR7R8, —NR7C(O)Rb, —S(O)2NR8R9, —S(O)2R C, —NR8SO2NR8R9, NR8SO2Rc, —(CF2)rCF3, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-6 cycloalkyl, C1-4 haloalkyl, or C1-4 haloalkoxy;
alternately, when R1 and R2 groups are substituted on adjacent ring atoms, they can be taken together with the ring atoms to which they are attached to form a 5- to 7-membered carbocycle or heterocycle comprising: carbon atoms and 0-4 heteroatoms selected from N, O, and S(O)p, wherein said carbocycle or heterocycle is substituted with 0-2 R2b;
R3 is, independently at each occurrence, —(CH2)r-phenyl substituted with 0-3 R3a and 0-1 R3d, —(CH2)r-naphthyl substituted with 0-3 R3a and 0-1 R3d, —(CH2)r-indanyl substituted with 0-3 R3a and 0-1 R3d or —(CH2)r-5-10 membered heterocycle comprising: carbon atoms and 1-4 heteroatoms selected from N, O, and S(O)p, and substituted with 0-3 R3a and 0-1 R3d;
R3a is, independently at each occurrence, ?O, F, Cl, Br, I, OCF3, CF3, NO2, CN, —(CH2)rOR3b, —(CH2)rSR3b, —(CH2)rNR7R8, C(?NR8a)NR8R9, —NHC(?NR8a)NR7R8, —NR8CR8(?NR8a), —(CH2)rNR8C(O)R3b, ?NR8, —(CH2)rNR8C(O)R3b, —(CH2)rNR8C(O)2R3b, —(CH2)rS(O)pNR8R9, —(CH2)rNR8S(O)pR3c, —S(O)pR3c, —S(O)pR3c, —C(O)—C1-4 alkyl, —(CH2)rCO2R3 b, —(CH2)rC(O)NR8R9, —(CH2)rOC(O)NR8R9, —NHCOCF3, —NHSO2CF3, —SO2 NHR3b, —SO2NHCOR3c, —SO2NHCO2R3c, —CONHSO2R3c, —NHSO2R3c, —CONHOR3b, C1-4 haloalkyl, C1-4 haloalkoxy-, C1-6 alkyl substituted by R3d, C2-6 alkenyl substituted by R3d, C2-6 alkynyl substituted by R3d, C3-6 cycloalkyl substituted by 0-1 R3d, —(CH2)r—C3-10 carbocycle substituted with 0-3 R3d, or —(CH2)r-5- to 10-membered heterocycle comprising: carbon atoms and 1-4 heteroatoms selected from N, O, and S(O)p, wherein said heterocycle is substituted with 0-3 R3d;
alternately, when two R3a groups are located on adjacent atoms, they can be taken together with the atoms to which they are attached to form a C3-10 carbocycle substituted with 0-2 R3d or a 5- to 10-membered heterocycle comprising: carbon atoms and 1-4 heteroatoms selected from N, O, and S(O)p, wherein said heterocycle is substituted with 0-2 R3d;
R3b is, independently at each occurrence, H, C1-6 alkyl substituted with 0-2 R3d, C2-6alkenyl substituted with 0-2 R3d, C2-6 alkynyl substituted with 0-2 R3d, —(CH2)r—C3-10 carbocycle substituted with 0-3 R3d, or —(CH2)r-5- to 10-membered heterocycle comprising: carbon atoms and 1-4 heteroatoms selected from N, O, and S(O)p, wherein said heterocycle is substituted with 0-3 R3d;
R3c is, independently at each occurrence, C1-6 alkyl substituted with 0-2 R3d, C2-6 alkenyl substituted with 0-2 R3d, C2-6 alkynyl substituted with 0-2 R3d, —(CH2)r—C3-10 carbocycle substituted with 0-3 R3d, or —(CH2)r-5- to 10-membered heterocycle comprising: carbon atoms and 1-4 heteroatoms selected from N, O, and S(O)p, wherein said heterocycle is substituted with 0-3 R3d;
R3d is, independently at each occurrence, H, ?O, —(CH2)rORa, F, Cl, Br, CN, NO2, —(CH2)rNR7R8, —C(O)Ra, —C(O)ORa, —OC(O)Ra, —NR7C(O)Rb, —C(O)NR8R9, —SO2NR8R9, —NR8SO2NR8R9, —NR8SO2Rc, —S(O)pRc, —(CF2)rCF3, C1-6 alkyl substituted with 0-2 Re, C2-6 alkenyl substituted with 0-2 Re, C2-6 alkynyl substituted with 0-2 Re, —(CH2)r—C3-10 carbocycle substituted with 0-3 Rd, or —(CH2)r-5- to 10-membered heterocycle comprising carbon atoms and 1-4 heteroatoms selected from N, O, and S(O)p, wherein said heterocycle is substituted with 0-3 Rd;
R4 is H;
R7 is, independently at each occurrence, H, C1-6 alkyl, —(CH2)n-C3-10 carbocycle, —(CH2)n-(5-10 membered heteroaryl), —C(O)Rc, —CHO, —C(O)2Rc, —S(O)2Rc, —CONR8Rc, —OCONHRc, —C(O)O—(C1-4 alkyl)OC(O)—(C1-4 alkyl), or —C(O)O—(C1-4 alkyl)OC(O)—(C6-10 aryl); wherein said alkyl, carbocycle, heteroaryl, and aryl are optionally substituted with 0-2 Rf;
R8 is, independently at each occurrence, H, C1-6 alkyl, or —(CH2)r-phenyl, or —(CH2)n-5-10 membered heterocycle comprising: carbon atoms and 1-4 heteroatoms selected from N, O, and S(O)p; wherein said alkyl, phenyl and heterocycle are optionally substituted with 0-2 Rf;
alternatively, R7 and R8, when attached to the same nitrogen, combine to form a 5- to 10-membered heterocyclic ring comprising carbon atoms and 0-2 additional heteroatoms selected from N, O, and S(O)p, wherein said heterocycle is substituted with 0-2 Rd;
R8a is, independently at each occurrence, H, OH, C1-6 alkyl, C1-4 alkoxy, (C6-10 aryl)-C1-4 alkoxy, —(CH2)n-phenyl, —(CH2)n-(5-10 membered heteroaryl), —C(O)Rc, —C(O)2Rc, —C(O)O—(C1-4 alkyl)OC(O)—(C1-4 alkyl), or —C(O)O—(C1-4 alkyl)OC(O)—(C6-10 aryl); wherein said phenyl, aryl, and heteroaryl is optionally substituted with 0-2 Rf;
R9 is, independently at each occurrence, H, C1-6 alkyl, or —(CH2)n-phenyl; wherein said alkyl and phenyl are optionally substituted with 0-2 Rf;
R9a is, independently at each occurrence, H, C1-6 alkyl, or —(CH2)n-phenyl;
alternatively, R8 and R9, when attached to the same nitrogen, combine to form a 5- to 10-membered heterocyclic ring comprising carbon atoms and 0-2 additional heteroatoms selected from N, O, and S(O)p, wherein said heterocycle is substituted with 0-2 Rd;
R11 is —CH2-phenyl;
Ra is, independently at each occurrence, H, CF3, C1-6 alkyl, —(CH2)r—C3-7 cycloalkyl, —(CH2)r—C6-10 aryl, or —(CH2)r-5- to 10-membered heterocycle comprising: carbon atoms and 1-4 heteroatoms selected from N, O, and S(O)p; wherein said cycloalkyl, aryl and heteroaryl groups are optionally substituted with 0-2 Rf;
Rb is, independently at each occurrence, CF3, OH, C1-4 alkoxy, C1-6 alkyl, —(CH2)r—C3-10 carbocycle substituted with 0-3 Rd, or —(CH2)r-5-10 membered heterocycle comprising: carbon atoms and 1-4 heteroatoms selected from N, O, and S(O)p, wherein said heterocycle is substituted with 0-3 Rd;
Rc is, independently at each occurrence, CF3, C1-6 alkyl substituted with 0-2 Rf, C3-6 cycloalkyl substituted with 0-2 Rf, C6-10 aryl, 5- to 10-membered heteroaryl, (C6-10 aryl)-C1-4 alkyl, or (5- to 10-membered heteroaryl)-C1-4 alkyl, wherein said aryl and heteroaryl groups are optionally substituted with 0-3 Rf;
Rd is, independently at each occurrence, H, ?O, ?NR8, ORa, F, Cl, Br, I, CN, NO2, —NR7R8, —C(O)Ra, —C(O)ORa, —OC(O)Ra, —NR8C(O)Ra, —C(O)NR7R8, —SO2NR8SR9, —NR8SO2 NR8R9, —NR8SO2—C1-4 alkyl, —NR8SO2CF3, —NR8SO2-phenyl, —S(O)2CF3, —S(O)p—C1-4 alkyl, —S(O)p-phenyl, —(CF2)rCF3, C1-6 alkyl substituted with 0-2 Re, C2-6 alkenyl substituted with 0-2 Re, or C2-6 alkynyl substituted with 0-2 Re;
Re is, independently at each occurrence, ?O, ORa, F, Cl, Br, I, CN, NO2, —NR8R9, —C(O)Ra, —C(O)ORa, —OC(O)Ra, —NR8C(O)Ra, —C(O)NR7R8, —SO2NR8R9, NR8SO2NR8R9, —NR8SO2—C1-4 alkyl, —NR8SO2CF3, —NR8SO2-phenyl, —S(O)2CF3, —S(O)p—C1-4 alkyl, —S(O)p-phenyl, or —(CF2)rCF3;
Rf is, independently at each occurrence, H, ?O, —(CH2)r—OR, F, Cl, Br, I, CN, NO2, —NR9aR9a, —C(O)R9, —C(O)ORg, —NR9aC(O)R9, —C(O)NR9aR9a, —SO2NR9aR9a, —NR9aSO2NR9aR9a, —NR9aSO2—C1-4 alkyl, —NR9aSO2CF3, —NR9aSO2-phenyl, —S(O)2CF3, —S(O)p—C1-4 alkyl, —S(O)p-phenyl, —(CF2)rCF3, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, or —(CH2)n-phenyl;
Rg is, independently at each occurrence, H, C1-6 alkyl, or —(CH2)n-phenyl;
n, at each occurrence, is selected from 0, 1, 2, 3, and 4;
p, at each occurrence, is selected from 0, 1, and 2; and
r, at each occurrence, is selected from 0, 1, 2, 3, and 4.

US Pat. No. 10,112,931

3-PYRIMIDIN-4-YL-OXAZOLIDIN-2-ONES AS INHIBITORS OF MUTANT IDH

NOVARTIS AG, Basel (CH)

1. A compound according to formula (V)
wherein:
R2a is methyl or C1-3 haloalkyl;
R5 and R6 are each independently hydrogen, deuterium, halo, —C(O)OCH3, C1-3 alkyl or C1-3 haloalkyl;
R7 is

wherein:
ring A is a 6 membered heteroaryl ring having one to three nitrogen atoms;
ring B is a 5 membered heteroaryl ring having one to four heteroatoms each independently selected from the group consisting of N, O and S;
each R8 is independently hydrogen, halo, C1-3 alkyl, C1-3 haloalkyl, C1-3 alkoxy or C1-3 haloalkoxy;
n is 1 or 2;
R9 is hydrogen, halo, C1-3 haloalkyl, optionally substituted C1-6 alkyl, optionally substituted C3-6 cycloalkyl, optionally substituted aryl, optionally substituted 5 or 6 membered heterocyclic, optionally substituted heteroaryl, —OR9a, —SO2R9a, C(O)NHR9a, CH2R9b or CHCH3R9b, wherein:
said C1-6 alkyl is optionally substituted with one to three substituents each independently selected from the group consisting of: OH, phenyl and phenoxy, and
said C3-6 cycloalkyl, 5 or 6 membered heterocyclic, aryl and heteroaryl are each optionally substituted with one to three substituents each independently selected from the group consisting of: halo, hydroxyl, cyano, NRR, C1-6 alkyl, C1-6 haloalkyl, C1-3 alkoxy, and C1-3 haloalkoxy;
R9a is optionally substituted C1-6 alkyl, C1-6 haloalkyl, optionally substituted C3-6 cycloalkyl, optionally substituted phenyl, or optionally substituted heterocyclic,
wherein:
said C1-6 alkyl is optionally substituted with one C3-6 cycloalkyl,
said C3-6 cycloalkyl and heterocyclic are each optionally substituted with one to three substituents each independently selected from the group consisting of: hydroxyl, CH2OH, —NRR, cyano, C1-3 alkyl, C1-3 haloalkyl, and C1-3 alkoxy, and
said phenyl is optionally substituted with one to three substituents each independently selected from the group consisting of: halo, hydroxyl, cyano, NRR, C1-6 alkyl, C1-6 haloalkyl, C1-3 alkoxy, and C1-3 haloalkoxy;
R9b is optionally substituted C3-6 cycloalkyl, optionally substituted phenyl or optionally substituted heterocyclic,
said C3-6 cycloalkyl and heterocyclic are each optionally substituted with one to four substituents each independently selected from the group consisting of: hydroxyl, CH2OH, —NRR, —NRC(O)CH3, 4 to 6 membered heterocyclic, cyano, halo, C1-3 alkyl, C1-3 haloalkyl, and C1-3 alkoxy, and said phenyl is optionally substituted with one to three substituents each independently selected from the group consisting of: halo, hydroxyl, cyano, C1-6 alkyl, C1-6 haloalkyl, C1-3 alkoxy, and C1-3 haloalkoxy; and
each R is independently selected from the group consisting of H, C1-3 alkyl and C3-6 cycloalkyl; or a pharmaceutically acceptable salt thereof.

US Pat. No. 10,112,930

COMPOSITIONS AND METHODS FOR CONTROLLING NEMATODES

Monsanto Technology LLC, ...

1. A method for control of plant parasitic nematodes, the method comprising administering to a plant, a seed or soil a composition comprising an effective amount of a compound of Formula III or a salt thereof,
wherein,
A is phenyl or pyrazyl, each of which can be optionally independently substituted with one or more substituents selected from the group consisting of halogen, CF3, CH3, OCF3, OCH3, CN and C(H)O; and
C is thienyl, furanyl, oxazolyl, or isoxazolyl, each of which can be optionally independently substituted with one or more substituents selected from the group consisting of fluorine, chlorine, CH3 and OCF3.

US Pat. No. 10,112,929

LACTAMS AS INHIBITORS OF ROCK

Bristol-Myers Squibb Comp...

1. A compound according to Formula (I):
or an enantiomer, a diastereomer, a stereoisomer, a tautomer, or a pharmaceutically acceptable salt thereof, wherein
Ring A is independently selected from

J1, J2, J3, and J4 are independently selected from N, CR3 and CR4; provided no more than two of J1, J2, J3, and J4 are N;
K is independently selected from the group consisting of N, CR1 and CR2;
L is NR6(CR7R7)m;
R1 is independently selected from the group consisting of H, F, Cl, Br, OH, CN, NRaRa, —OC1-4 alkyl substituted with 0-3 Re, and C1-4 alkyl substituted with 0-3 Re;
R2 is independently selected from the group consisting of H, F, Cl, Br, —(CH2)rORb, (CH2)rS(O)pRc, —(CH2)rC(?O)Rb, —(CH2)rNRaRa, —(CH2)rCN, —(CH2)rC(?O)NRaRa, —(CH2)rNRaC(?O)Rb, —(CH2)rNRaC(?O)NRaRa, —(CH2)NRaC(?O)ORb, —(CH2)rOC(?O)NRaRa, —(CH2)rC(?O)ORb, —(CH2)rS(O)pNRaRa, —(CH2)rNRaS(O)pNRaRa, —(CH2)rNRaS(O)pRc, (CH2)r—C3-6 carbocyclyl substituted with 0-3 Re, and —(CH2)r-heterocyclyl substituted with 0-3 Re;
R3 is independently selected from the group consisting of H, F, Cl, Br, CN, C1-4 alkyl substituted with 0-3 Re, —(CH2)rORb, (CH2)rS(O)pRc, —(CH2)rC(?O)Rb, —(CH2)rNRaRa, —(CH2)rC(?O)NRaRa, —(CH2)rC(?O)(CH2)rNRaRa, —(CH2)rCN, —(CH2)rNRaC(?O)Rb, —(CH2)rNRaC(?O)ORb, —(CH2)rOC(?O)NRaRa, —(CH2)rNRaC(?O)NRaRa, —(CH2)k(?O)ORb, —(CH2)rS(O)pNRaRa, —(CH2)rNRaS(O)pNRaRa, —(CH2)rNRaS(O)pRc, (CH2)r—C3-6 carbocyclyl substituted with 0-3 Re, and —(CH2)r-heterocyclyl substituted with 0-3 Re;
R4 is independently selected from the group consisting of H, F, Cl, Br, OH, CN, OC1-4 alkyl substituted with 0-3 Re, NRaRa, and C1-4 alkyl substituted with 0-3 Re;
R5 is independently selected from the group consisting of H, ?O, C1-4alkyl substituted with 0-4 Re, —(CH2)rORb, (CH2)rS(O)pRc, —(CH2)rC(?O)Rb, —(CH2)rNRaRa, —(CH2)rCN, —(CH2)rC(?O)NRaRa, —(CH2)rNRaC(?O)Rb, —(CH2)rNRaC(?O)NRaRa, —(CH2)rNRaC(?O)ORb, —(CH2)rOC(?O)NRaRa, —(CH2)rC(?O)ORb, —(CH2)rS(O)pNRaRa, —(CH2)rNRaS(O)pNRaRa, —(CH2)rNRaS(O)pRc, (CH2)r—C3-6 carbocyclyl substituted with 0-3 Re, and —(CH2)r-heterocyclyl substituted with 0-3 Re;
R6 is independently selected from the group consisting of H and C1-4alkyl substituted with 0-4 Re;
R7 is independently selected from H, C1-4alkyl substituted with 0-4 Re, —(CH2)rORb, —(CH2)rS(O)pRc, —(CH2)rC(?O)Rb, —(CH2)rNRaRa, —(CH2)rC(?O)NRaRa, —(CH2)rC(?O)(CH2)rNRaRa, —(CH2)rNRaC(?O)Rb, —(CH2)rNRaC(?O)ORb, —(CH2)rOC(?O)NRaRa, —(CH2)rNRaC(?O)NRaRa, —(CH2)k(?O)ORb, —(CH2)rS(O)pNRaRa, —(CH2)rNRaS(O)pNRaRa, —(CH2)rNRaS(O)pRc, (CH2)r—C3-6 carbocyclyl substituted with 0-3 Re, and —(CH2)r-heterocyclyl substituted with 0-3 Re; alternatively, R7 and R7 form ?O;
R8 is independently selected from the group consisting of C3-6 cycloalkyl, heterocyclyl, aryl and heteroaryl, each substituted with 0-5 R9;
alternatively, when m is zero, R8 and R6 together with the nitrogen atom to which they are both attached form a heterocyclic ring substituted with 0-5 R9;
R9 is independently selected from the group consisting of H, ?O, F, Cl, Br, C1-4alkyl, C2-4alkenyl, C2-4alkynyl, nitro, —(CRdRd)rS(O)pRc, —(CRdRd)rS(O)pNRaRa, —(CRdRd)rNRaS(O)pRc, —(CRdRd)rORb, —(CRdRd)rCN, —(CRdRd)rNRaRa, —(CRdRd)rNRaC(?O)Rb, —(CRdRd)rNRaC(?O)NRaRa, —(CRdRd)rNRaC(?O)ORb, —(CRdRd)rC(?O)ORb, —(CRdRd)rC(?O)NRaRa, —(CRdRd)rC(?O)Rb, —(CRdRd)rOC(?O)Rb, —(CRdRd)rOC(?O)NRaRa, —(CRdRd)r-cycloalkyl, —(CRdRd)r-heterocyclyl, —(CRdRd)r-aryl, and —(CRdRd)r-heteroaryl, wherein said alkyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl is substituted with 0-4 Re;
Ra, at each occurrence, is independently selected from the group consisting of H, C1-6 alkyl substituted with 0-5 Re, C2-6 alkenyl substituted with 0-5 Re, C2-6 alkynyl substituted with 0-5 Re, —(CH2)r—C3-10carbocyclyl substituted with 0-5 Re, and —(CH2)r-heterocyclyl substituted with 0-5 Re; or Ra and Ra together with the nitrogen atom to which they are both attached form a heterocyclic ring substituted with 0-5 Re;
Rb, at each occurrence, is independently selected from the group consisting of H, C1-6 alkyl substituted with 0-5 Re, C2-6 alkenyl substituted with 0-5 Re, C2-6 alkynyl substituted with 0-5 Re, —(CH2)r—C3-10carbocyclyl substituted with 0-5 Re, and —(CH2)r-heterocyclyl substituted with 0-5 Re;
Rc, at each occurrence, is independently selected from the group consisting of C1-6 alkyl substituted with 0-5 Re, C2-6alkenyl substituted with 0-5 Re, C2-6alkynyl substituted with 0-5 Re, C3-6carbocyclyl, and heterocyclyl;
Rd, at each occurrence, is independently selected from the group consisting of H and C1-4alkyl substituted with 0-5 Re;
Re, at each occurrence, is independently selected from the group consisting of C1-6 alkyl substituted with 0-5 Rf, C2-6 alkenyl, C2-6 alkynyl, —(CH2)r—C3-6 cycloalkyl, —(CH2)r—C4-6 heterocyclyl, —(CH2)r-aryl, —(CH2)r-heteroaryl, F, Cl, Br, CN, NO2, ?O, CO2H, —(CH2)rORf, S(O)pRf, C(?O)NRfRf, NRfC(?O)Rd, S(O)pNRfRf, NRfS(O)pRd, NRfC(?O)ORd, OC(?O)NRfRf and —(CH2)rNRfRf;
Rf, at each occurrence, is independently selected from the group consisting of H, F, Cl, Br, CN, OH, C1-5alkyl, C3-6 cycloalkyl, and phenyl; or Rf and Rf together with the nitrogen atom to which they are both attached form a heterocyclic ring optionally substituted with C1-4alkyl;
m is independently selected from zero, 1, and 2;
p, at each occurrence, is independently selected from zero, 1, and 2; and
r, at each occurrence, is independently selected from zero, 1, 2, 3, and 4.

US Pat. No. 10,112,928

INHIBITORS OF SYK

HOFFMANN-LA ROCHE INC., ...

1. A compound of Formula I
wherein:
R1 is —OR1? or (CH2)nR1?;
R1? is phenyl, pyridyl, cycloalkyl, amino cycloalkyl C1-6 alkyl or C1-6 alkyl, optionally substituted with one or more R1?;
each R1? is independently cyano, amino, amino C1-6 alkyl, halo, C1-6 alkyl, cycloalkyl, or amino cycloalkyl C1-6 alkyl;
R2 is C1-6 alkyl, cycloalkyl, cyano C1-6 alkyl, hydroxy C1-6 alkyl, halo C1-6 alkyl, dialkyl amino, or C1-6 alkoxy;
R3 is absent;
R4 is H or C1-6 alkyl;
X1 is CH or N;
X2 is CH, CR2 or N;
X3 is CH or N;
Y1 is N; and
Y2 is N;
Y3 is CH; and
n is 0 or 1;
or a pharmaceutically acceptable salt thereof.

US Pat. No. 10,112,926

AMINO PYRIDINE DERIVATIVES AS PHOSPHATIDYLINOSITOL 3-KINASE INHIBITORS

Novartis AG, Basel (CH)

1. A compound of formula (I)
or a pharmaceutically acceptable salt thereof, wherein
E is selected from N and CRE;
R1, R2 and RE are independently selected from H, halogen, C1-4 alkyl, C1-4 alkoxy, C1-4 haloalkyl, C1-4 haloalkoxy, C1-4 hydroxyalkyl and C3-7 cycloalkyl;
R3 is selected from
(i) C1-4 alkyl which is unsubstituted or substituted with 1 or more substituents independently selected from hydroxy, C1-4 hydroxyalkyl, halogen, C1-4 haloalkyl, C1-4 alkoxy, C1-4 alkyl, oxo, CN, —(C0-3 alkyl)-NR3aR3b, C3-7 cycloalkyl and C3-7 heterocyclyl, and wherein the C3-7 cycloalkyl or C3-7 heterocyclyl is unsubstituted or substituted with 1 to 3 substituents independently selected from hydroxy, C1-4 hydroxyalkyl, halogen, C1-4 alkyl, C1-4 alkoxy, C1-4 haloalkyl, oxo and —(C0-3 alkyl)-NR3aR3b;
(ii) C1-4 alkoxy which is unsubstituted or substituted with 1 or more substituents independently selected from hydroxy, C1-4 hydroxyalkyl, halogen, C1-4 haloalkyl, C1-4 alkoxy, C1-4 alkyl, oxo, CN, —(C0-3 alkyl)-NR3aR3b, C3-7 cycloalkyl and C3-7 heterocyclyl, and wherein the C3-7 cycloalkyl or C3-7 heterocyclyl is unsubstituted or substituted with 1 to 3 substituents independently selected from hydroxy, C1-4 hydroxyalkyl, halogen, C1-4 alkyl, C1-4 alkoxy, C1-4 haloalkyl, oxo and —(C0-3 alkyl)-NR3aR3b;
(iii) —C3-7 cycloalkyl or —O—C3-7 cycloalkyl wherein the C3-7 cycloalkyl is unsubstituted or substituted with 1 to 3 substituents independently selected from hydroxy, C1-4 hydroxyalkyl, halogen, C1-4 alkyl, C1-4 alkoxy, C1-4 haloalkyl, oxo and —(C0-3 alkyl)-NR3aR3b;
(iv) —(C0-3 alkyl)-C3-7 cycloalkyl or —O—(C0-3 alkyl)-C3-7 cycloalkyl wherein the C3-7 cycloalkyl is spiro fused to a second C3-7 cycloalkyl or C3-7 heterocyclyl by one single carbon atom, and wherein the C3-7 cycloalkyl or C3-7 heterocyclyl is unsubstituted or substituted with 1 to 3 substituents independently selected from hydroxy, C1-4 hydroxyalkyl, halogen, C1-4 alkyl, C1-4 alkoxy, C1-4 haloalkyl, oxo and —(C0-3 alkyl)-NR3aR3b;
(v) —(C0-3 alkyl)-C3-7 heterocyclyl or —O—(C0-3 alkyl)-C3-7 heterocyclyl, and wherein said C3-7 heterocyclyl is unsubstituted or substituted with 1 to 3 substituents independently selected from hydroxy, C1-4 hydroxyalkyl, halogen, C1-4 alkyl, C1-4 alkoxy, C1-4 haloalkyl, oxo and —(C0-3 alkyl)-NR3aR3b;
(vi) —(C0-3 alkyl)-C3-7 heterocyclyl or —O—(C0-3 alkyl)-C3-7 heterocyclyl, and wherein said C3-7 heterocyclyl is spiro fused to a second C3-7 heterocyclyl or a C3-7 cycloalkyl by one single carbon atom, and wherein the C3-7 heterocyclyl or C3-7 cycloalkyl is unsubstituted or substituted with 1 to 3 substituents independently selected from hydroxy, C1-4 hydroxyalkyl, halogen, C1-4 alkyl, C1-4 alkoxy, C1-4 haloalkyl, oxo and —(C0-3 alkyl)-NR3aR3b;
(vii) pyridyl wherein the pyridyl is unsubstituted or substituted with 1 to 3 substituents independently selected from C1-4 alkyl, C1-4 alkoxy, hydroxy, C1-4 hydroxyalkyl, halogen, C1-4 haloalkyl and —(C0-3 alkyl)-NR3aR3b; and
(viii) H;
R4 is selected from H and C1-4 alkyl; or
R3 and R4 together with the nitrogen atom to which they are attached form a C3-7 heterocyclyl, which C3-7 heterocyclyl is optionally spiro fused to a second C3-7 heterocyclyl or a C3-7 cycloalkyl by one single carbon atom, and which C3-7 heterocyclyl and C3-7 cycloalkyl are unsubstituted or substituted with 1 to 3 substituents independently selected from hydroxy, C1-4 hydroxyalkyl, halogen, C1-4 alkyl, C1-4 alkoxy, C1-4 haloalkyl, oxo and —(C0-3 alkyl)-NR3aR3b;
R3a and R3b are independently selected from H, C1-4 alkyl and C1-4 haloalkyl;
Y is selected from the group consisting of
oxazol-5-yl,
thiazol-5-yl,
thiazol-4-yl,
isothiazol-5-yl,
pyrazol-4-yl,
pyrazol-1-yl,
pyrid-4-yl,
1,2,4-triazol-1-yl,
1,2,3-triazol-4-yl,
1,2,4-oxadiazol-5-yl,
1,3,4-oxadiazol-2-yl,
isoxazol-5-yl,
isoxazol-4-yl, and
pyrrol-3-yl,
each of which is unsubstituted or substituted with 1 to 3 substituents independently selected from C1-4 alkyl, C1-4 haloalkyl, —(C?O)—C3-7 heterocyclyl, —(C0-3 alkyl)-NR?R? and —(C?O)—NR?R?; and
R? and R? are independently selected from H and C1-4 alkyl;
or a pharmaceutically acceptable salt thereof.

US Pat. No. 10,112,922

INHIBITOR OF BRUTON'S TYROSINE KINASE

Centaurus BioPharma Co., ...

1. A compound represented by Formula (III), or a pharmaceutically acceptable salt, solvate, metabolite, polymorph, ester, tautomer or prodrug thereof,wherein:Y and R15 join to form a 5-membered heterocyclic ring;
G is selected from the group consisting of H,
wherein R7, R8 and R9 are each independently selected from the group consisting of H, halogen, —COOH, substituted or unsubstituted lower alkyl, and substituted or unsubstituted lower heteroalkyl;R6 is H; and
n is 0, 1, 2, 3 or 4.

US Pat. No. 10,112,920

BETA- AND GAMMA-AMINO-ISOQUINOLINE AMIDE COMPOUNDS AND SUBSTITUTED BENZAMIDE COMPOUNDS

Aerie Pharmaceuticals, In...


or a pharmaceutically acceptable salt thereof.

US Pat. No. 10,112,919

METHODS OF PREPARING OXA-BICYCLOALKENE

1. A method of preparing an oxa-bicycloalkene comprising reacting (i) a cycloalkanone and (ii) an allyl alcohol compound in the presence of an organic acid, a manganese catalyst, and oxygen at a temperature of 60 to 200° C. for 1 to 24 hours, wherein the oxa-bicycloalkene is 3,4,5,6,7,8,9,10,11,12,13,14-dodecahydro-2H-cyclododeca[b]pyran having the following Formula (IV):
the cycloalkanone is cyclododecanone of Formula (V):
andthe allyl alcohol compound is allyl acetate or allyl alcohol.

US Pat. No. 10,112,915

3-ARYL BICYCLIC [4,5,0] HYDROXAMIC ACIDS AS HDAC INHIBITORS

Forma Therapeutics, Inc.,...

1. A compound of Formula I:
or a pharmaceutically acceptable salt, hydrate, tautomer or isomer thereof,wherein:X1 is O;
X2 and X4 are each CR1R2;
X3 is CR1?R2?;
Y1 and Y4 are not bonded to —C(O)NHOH and are each CR1;
Y2 and Y3 are each CR1 when not bonded to —C(O)NHOH and Y2 and Y3 are C when bonded to —C(O)NHOH;
L is selected from the group consisting of a bond, —(CR1R2)n—, —C(O)O—, —C(O)NR3—, —S(O)2—, —S(O)2NR3—, —S(O)—, and —S(O)NR3—, wherein L is bound to the ring nitrogen through the carbonyl or sulfonyl group;
R is independently selected from the group consisting of —H, —C1-C6 alkyl, —C2-C6 alkenyl, —C4-C8 cycloalkenyl, —C2-C6 alkynyl, —C3-C8 cycloalkyl, —C5-C12 spirocycle, heterocyclyl, spiroheterocyclyl, aryl, and heteroaryl containing 1 to 5 heteroatoms selected from the group consisting of N, S, P, and O, wherein each alkyl, alkenyl, cycloalkenyl, alkynyl, cycloalkyl, spirocycle, heterocyclyl, spiroheterocyclyl, aryl, or heteroaryl is optionally substituted with one or more substituents selected from the group consisting of —OH, halogen, oxo, —NO2, —CN, —R1, —R2, —OR3, —NHR3, —NR3R4, —S(O)2NR3R4, —S(O)2R1, —C(O)R1, —CO2R1, —NR3S(O)2R1, —S(O)R1, —S(O)NR3R4, —NR3S(O)R1, heterocycle, aryl, and heteroaryl containing 1 to 5 heteroatoms selected from the group consisting of N, S, P, and O;
each R1 and R2 are independently, and at each occurrence, selected from the group consisting of —H, —R3, —R4, —C1-C6 alkyl, —C2-C6 alkenyl, —C4-C8 cycloalkenyl, —C2-C6 alkynyl, —C3-C8 cycloalkyl, heterocyclyl, aryl, heteroaryl containing 1 to 5 heteroatoms selected from the group consisting of N, S, P, and O, —OH, halogen, —NO2, —CN, —NHC1-C6 alkyl, —N(C1-C6 alkyl)2, —S(O)2N(C1-C6 alkyl)2, —N(C1-C6 alkyl)S(O)2R5, —S(O)2(C1-C6 alkyl), —(C1-C6 alkyl)S(O)2R5, —C(O)C1-C6 alkyl, —CO2C1-C6 alkyl, —N(C1-C6 alkyl)S(O)2C1-C6 alkyl, and —(CHR5)nNR3R4, wherein each alkyl, alkenyl, cycloalkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl is optionally substituted with one or more substituents selected from the group consisting of —OH, halogen, —NO2, oxo, —CN, —R5, —OR3, —NHR3, NR3R4, —S(O)2N(R3)2, —S(O)2R5, —C(O)R5, —CO2R5, —NR3S(O)2R5, —S(O)R5, —S(O)NR3R4, —NR3S(O)R5, heterocycle, aryl, and heteroaryl containing 1 to 5 heteroatoms selected from the group consisting of N, S, P, and O;
R1? and R2? are independently, and at each occurrence, selected from the group consisting of H, aryl, and heteroaryl containing 1 to 5 heteroatoms selected from the group consisting of N, S, P, and O, wherein each aryl or heteroaryl is optionally substituted with one or more substituents selected from the group consisting of —OH, halogen, —NO2, oxo, —CN, —R3, —R5, —OR3, —NHR3, —NR3R4, —S(O)2N(R3)2, —S(O)2R5, —C(O)R5, —CO2R5, —NR3S(O)2R5, —S(O)R5, —S(O)NR3R4, —NR3S(O)R5, heterocycle, aryl, and heteroaryl containing 1 to 5 heteroatoms selected from the group consisting of N, S, P, and O, wherein at least one of R1? or R2? is not H;
R3 and R4 are independently, and at each occurrence, selected from the group consisting of —H, —C1-C6 alkyl, —C2-C6 alkenyl, —C4-C8 cycloalkenyl, —C2-C6 alkynyl, —C3-C8 cycloalkyl, heterocyclyl, aryl, heteroaryl containing 1 to 5 heteroatoms selected from the group consisting of N, S, P, and O, —S(O)2N(C1-C6 alkyl)2, —S(O)2(C1-C6 alkyl), —(C1-C6 alkyl)S(O)2R5, —C(O)C1-C6 alkyl, —CO2C1-C6 alkyl, and —(CHR5)nN(C1-C6 alkyl)2, wherein each alkyl, alkenyl, cycloalkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl is optionally substituted with one or more substituents selected from the group consisting of —OH, halogen, —NO2, oxo, —CN, —R5, —O(C1-C6) alkyl, —NH(C1-C6) alkyl, —N(C1-C6 alkyl)2, —S(O)2N(C1-C6 alkyl)2, —S(O)2NHC1-C6 alkyl, —C(O)C1-C6 alkyl, —CO2C1-C6 alkyl, —N(C1-C6 alkyl)S(O)2C1-C6 alkyl, —S(O)R5, —S(O)N(C1-C6 alkyl)2, —N(C1-C6 alkyl)S(O)R5, heterocycle, aryl, and heteroaryl containing 1 to 5 heteroatoms selected from the group consisting of N, S, P, and O;
or R3 and R can combine with the nitrogen atom to which they are attached to form a heterocycle or heteroaryl containing 1 to 5 heteroatoms selected from the group consisting of N, S, P, and O, wherein each heterocycle or heteroaryl is optionally substituted with —R4, —OR4, or —NR4R5;
R5 is independently, and at each occurrence, selected from the group consisting of —H, —C1-C6 alkyl, —C2-C6 alkenyl, —C4-C8 cycloalkenyl, —C2-C6 alkynyl, —C3-C8 cycloalkyl, heterocyclyl, aryl, heteroaryl containing 1 to 5 heteroatoms selected from the group consisting of N, S, P, and O, —OH, halogen, —NO2, —CN, —NHC1-C6 alkyl, —N(C1-C6 alkyl)2, —S(O)2NH(C1-C6 alkyl), —S(O)2N(C1-C6 alkyl)2, —S(O)2C1-C6 alkyl, —C(O)C1-C6 alkyl, —CO2C1-C6 alkyl, —N(C1-C6 alkyl)SO2C1-C6 alkyl, —S(O)(C1-C6 alkyl), —S(O)N(C1-C6 alkyl)2, —N(C1-C6 alkyl)S(O)(C1-C6 alkyl), and —(CH2)nN(C1-C6 alkyl)2; and
each n is independently and at each occurrence an integer from 0 to 6.

US Pat. No. 10,112,913

SUBSTITUTED [1,2,4]TRIAZOLE AND IMIDAZOLE COMPOUNDS AS FUNGICIDES

BASF SE, Ludwigshafen (D...

1. A compound of the formula I
wherein
A is CH or N;
R1 is C1-C6-alkyl, C2-C6-alkenyl, C2-C6-alkynyl or C3-C6-cycloalkyl;
wherein the aliphatic moieties of R1 are not further substituted or carry one, two, three or up to the maximum possible number of identical or different groups R1a which independently of one another are selected from:
R1a halogen, OH, CN, C1-C4-alkoxy, C3-C6-cycloalkyl, C3-C6-halogencycloalkyl and C1-C4-halogenalkoxy;
wherein the cycloalkyl moieties of R1 are not further substituted or carry one, two, three, four, five or up to the maximum number of identical or different groups R1b which independently of one another are selected from:
R1b halogen, OH, CN, C1-C4-alkoxy, C1-C4-halogenalkyl, C3-C6-cycloalkyl, C3-C6-halogencycloalkyl and C1-C4-halogenalkoxy;
R2 is hydrogen, C1-C4-alkyl, C2-C4-alkenyl or C2-C4-alkynyl;
wherein the aliphatic moieties of R2 are not further substituted or carry one, two, three or up to the maximum possible number of identical or different groups R2a which independently of one another are selected from:
R2a halogen, OH, CN, C1-C4-alkoxy, C3-C6-cycloalkyl, C3-C6-halogencycloalkyl and C1-C4-halogenalkoxy;
R3 is selected from halogen, CN, C1-C4-alkyl, C1-C4-alkoxy, C2-C4-alkenyl, C2-C4-alkynyl, C3-C6-cycloalkyl and S(O)p(C1-C4-alkyl), wherein each of R3 is unsubstituted or further substituted by one, two, three or four R1a; wherein
R3a is independently selected from halogen, CN, OH, C1-C4-alkyl, C1-C4-halogenalkyl, C3-C6-cycloalkyl, C3-C6-halogencycloalkyl, C1-C4-alkoxy and C1-C4-halogenalkoxy;
p is 0, 1 or 2;
Z is CN, Si(C1-C4-alkyl)3, C1-C6-alkoxy or C(?O)—O—(C1-C6-alkyl);
wherein the aliphatic moieties of Z are not further substituted or carry one, two, three or four identical or different groups RZ, which independently of one another are selected from
RZ halogen, CN, OH, C1-C4-alkyl, C1-C4-halogenalkyl, C3-C6-cycloalkyl, C3-C6-halogencycloalkyl, O—C6H5, C1-C4-alkoxy and C1-C4-halogenalkoxy;
and the N-oxides and the agriculturally acceptable salts thereof.

US Pat. No. 10,112,912

HOMOPIPERAZINE-BASED CATALYSTS FOR NEUTRALIZATION OF ORGANOPHOSPHORUS-BASED COMPOUNDS

Lawrence Livermore Nation...

1. A composition of matter, comprising: a homopiperazine-based ligand; wherein the composition of matter has a structure selected from the group consisting of:
wherein each R is a chemical moiety independently selected from the group consisting of: hydrogen, an electron donating group, an electron withdrawing group, and a solubilizing ligand.

US Pat. No. 10,112,907

SUBSTITUTED INDAZOLES FOR TREATING TENDON AND/OR LIGAMENT INJURIES

NOVARTIS AG, Basel (CH)

10. A pharmaceutical composition comprising a therapeutically effective amount of a compound according to claim 1, or a pharmaceutically acceptable salt thereof, and one or more pharmaceutically acceptable carriers.

US Pat. No. 10,112,902

FUNGICIDAL PYRIDYLAMIDINES

Syngenta Participations A...

1. A compound of formula (I)
wherein
R1 and R2 independently represent hydrogen, C1-C4alkyl, C1-C4fluoroalkyl or C3-C6cycloalkyl; or
R1 and R2 together with the nitrogen atom to which they are attached form a three to six-membered saturated cyclic group which may optionally contain one oxygen or one sulphur atom;
R3 represents fluorine, chlorine, bromine, C1-C4 alkyl, C1-C4 alkenyl, C1-C4 haloalkyl, C1-C4 alkoxy or C3-C6 cycloalkyl;
R4 represents hydrogen, halogen, cyano, hydroxy, formyl, carboxy, amino, C1-C4 alkyl, C2-C6 alkenyl, C2-C6 alkynl, C1-C6 haloalkyl, C1-C6 alkoxy or C3-C6 cycloalkyl;
R5 represents hydrogen, halogen, cyano, C1-C4 alkyl, C1-C4 haloalkyl, C2-C4 alkynyl, C1-C4 alkoxy or C3-C6 cycloalkyl;
R6, R7, R8, R9 and R10 independently represent hydrogen or C1-C2 fluoroalkoxy;
wherein at least one of R6, R7, R8, R9 and R10 represent C1-C2 fluoroalkoxy;
or a tautomer, stereoisomer, enantiomer, salt or N-oxide thereof.

US Pat. No. 10,112,899

ISOINDOLINE DERIVATIVES FOR USE IN THE TREATMENT OF A VIRAL INFECTION

ViiV HEALTHCARE UK LIMITE...

1. A compound of Formula I:or a pharmaceutically acceptable salt thereof, wherein:R1 is C1-6alkyl;
R2 is C5-14aryl, C3-7cycloalkyl, C3-7cycloalkenyl, C2-9heterocycle, or C2-9heteroaryl, wherein each R2 group is optionally substituted by one to four substituents selected from halo, C1-6alkyl, C1-6hetereoalkyl, or C1-6alkylene or C1-6hetereoalklylene wherein said C1-6alkylene or C1-6hetereoalklylene are bonded to adjacent carbon atoms on said C5-14aryl, C3-7cycloalkyl, C3-7cycloalkenyl, C3-9heterocycle, or C5-9heteroaryl to form a fused ring;
L is a bond, —CH2(CO)—, —C1-3alkylene-, —SO2?, —C(O)—, —C(S)—, —C(NH)—, —C(O)NH—, —C(O)NHCH2—, —C(O)OCH2—, —C(O)O—, —C(O)C(O)—, —SO2—NH—, or —CH2C(O)—;
R3 is H, CN, C1-6alkyl, C5-14aryl, CH2C5-14aryl, CH2C3-7cycloalkyl, C3-7cycloalkyl, C3-7spirocycloalkyl, C3-7cycloalkenyl, C2-9heterocycle, or C2-9heteroaryl, wherein each R3 group is optionally substituted by one to four substituents selected from halo, C1-6alkyl, C2-8bridgedheterocycle, C3-7cycloalkyl, C1-3fluoroalkyl, —OC1-6alkyl, —C(O)R4, —C(O)NR4, —C(O)NHR4, C5-14aryl, C1-6hetereoalkyl, —B(OH)2, C2-9heterocycle, C1-6heteroaryl, —C(O)OC1-6alkyl, or two substituents bonded to adjacent atoms may bond together to form a fused ring and that fused ring may optionally be substituted with R4;
R4 is CN, halo, —OC1-6alkyl, C1-6alkyl, C3-7cycloalkyl, C2-9heterocycle, or C5-14aryl;
and wherein each heterocycle, heteroaryl, heteroalkyl, and heteroalkylene comprises
one to three heteroatoms selected from S, N, B, or O.

US Pat. No. 10,112,897

SUBSTITUTED N-ACETYL-L-CYSTEINE DERIVATIVES AND RELATED COMPOUNDS

Promentis Pharmaceuticals...

2. A pharmaceutical composition comprising the compound of claim 1 and a pharmaceutically acceptable carrier.

US Pat. No. 10,112,895

ANTIVIRALS AGAINST MOLLUSCUM CONTAGIOSUM VIRUS

The Trustees of the Unive...

1. A compound of formula (X) or (XII):wherein:Y is heteroaryl; which is substituted with at least one group selected from the group consisting of phenyl and heteroaryl;
R1, R2, R3, R4, R5, R6, R7, R8, and R9 are independently selected from the group consisting of H, C1-C6 alkyl, halo, cyano, nitro, SO2NH2, C1-C6 haloalkyl, ORa, SRa, NRmRn, NRaCORb, SORb, SO2Rb, CORb, COORa, aryl, heteroaryl, C3-C7 cycloalkyl, 3-7 membered heterocycloalkyl, cycloalkylalkyl, heterocycloalkylalkyl, arylalkyl, and heteroarylalkyl; or two adjacent ORa or NRmRn groups, together with the atoms to which they are attached, form a 5-7 membered heterocycloalkyl group;
R14 is H, C1-C3 alkyl, C(O)ORa, C(O)Rb, C(O)NRmRn, SORb, or SO2Rb;
Ra and Rb are each independently selected from the group consisting of H, C1-6 alkyl, C1-6 haloalkyl, C2-C6 alkenyl, C2-C6 alkynyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, cycloalkylalkyl, heterocycloalkylalkyl, arylalkyl, and heteroarylalkyl;
Rm and Rn are independently selected from the group consisting of H, C1-C6 alkyl, cycloalkyl, cycloalkylalkyl, heterocycloalkylalkyl, arylalkyl, and heteroarylalkyl; or Rm and Rn, together with the nitrogen atom to which they are attached, form a 3-7 membered heterocycloalkyl group;
each occurrence of aryl is independently selected from the group consisting of phenyl and naphthyl; and
each occurrence of heteroaryl is independently selected from the group consisting of pyridine, pyrimidine, pyrazine, indole, indolizine, benzimidazole, 1,3-dihydrobenzimidazol-2-one, and indazole.

US Pat. No. 10,112,891

STEREOSELECTIVE PROCESS TO OBTAIN (Z)-5-CYCLYLOXY-2-[(E)-METHOXYIMINO]-3-METHYL-PENT-3-ENIC ACID METHYL AMIDES USING E,Z-ISOMER MIXTURE OF AND INTERMEDIATES THEREOF

BASF SE, Ludwigshafen (D...

1. A process for preparing compounds of formula I
wherein
R is C1-C4-alkyl, C1-C4-haloalkyl, C3-C6-cycloalkyl or C3-C6-cycloalkyl-C1-C4-alkyl;
Y is hydrogen, C1-C4-alkoxy, C2-C4-alkenyl or benzyl; and
wherein the —CH2—OH group and the —C(?NOCH3)C(?O)NYCH3 group are on the same side of the C?C double bond between the carbon atoms depicted with the numbers 3 and 4 (Z-configuration), and
wherein the —OCH3 group and the —C(?O)NYCH3 group are on the opposite side of the C?N double bond between the carbon atom depicted with number 2 and the neighbouring nitrogen atom (E-configuration);
the process comprising:
reacting a compound of formula II

wherein R is as defined above;
with a compound of formula III

wherein Y is as defined above.

US Pat. No. 10,112,890

COMPOUND, SALT OF COMPOUND, EXTERNAL AGENT FOR SKIN, COSMETIC, AND FOOD ADDITIVE

SHOWA DENKO K.K., Minato...

1. A compound of Formula (1) or a salt thereof,
(in the formula, R1 and R2 each independently is a hydrogen atom or a linear or branched acyl group having 11 to 18 carbon atoms, a hydrocarbon group bonded to a carbonyl carbon of the acyl group is a saturated or unsaturated hydrocarbon group, and at least one of R1 and R2 is the acyl group).

US Pat. No. 10,112,887

CATALYSTS BASED ON AMINO-SULFIDE LIGANDS FOR HYDROGENATION AND DEHYDROGENATION PROCESSES

1. A metal complex of Formula II and IIIM(SN)pZa  II
M(SNS)Za  IIIwherein:each Z is simultaneously or independently a hydrogen or halogen atom, a C1-C6 alkyl, a carbene group, a hydroxyl group, or a C1-C7 alkoxy radical, a nitrosyl (NO) group, CO, CNR (R=Alkyl, Aryl), nitrile, phosphite, phosphinite, or phosphine;
M is a group 7, group 8, or group 9 transition metal;
p is equal to 1 or 2, whereas a is equal to 1, 2, or 3;
SN is a bidentate coordinated ligand of Formula IA, wherein the coordinating groups of the SN ligand consist of one thio group and one nitrogen group;
SNS is a tridentate coordinated ligand of Formula IB, wherein the coordinating groups of the SNS ligand consist of two thio groups and one nitrogen group:
wherethe dotted lines simultaneously or independently indicate single or double bonds;
R1, R2, R5, and R6 are each independently H, a substituted or unsubstituted linear or branched C1-C20 alkyl, a substituted or unsubstituted cyclic C3-C8 alkyl, or a substituted or unsubstituted C2-C20 alkenyl, a substituted or unsubstituted C5-C20 aryl, OR or NR2; or when taken together, R1 and R2 groups or R5 and R6 groups can form a saturated or partially saturated C5-C20 cycle;
R3 and R4 are each independently H, a substituted or unsubstituted linear, branched or cyclic C1-C8 alkyl or alkenyl, a substituted or unsubstituted C5-C8 aromatic group, ester group; or, when taken together, R3 and R4 can form an optionally substituted saturated or partially saturated C5-C20 hetero-aromatic ring;
R5 when taken together with R4 can form an optionally substituted saturated or partially saturated C5-C20 aromatic ring;
R7 is H, a substituted or unsubstituted linear or branched C1-C8 alkyl, a substituted or unsubstituted cyclic C3-C8 alkyl, a substituted or unsubstituted C2-C20 alkenyl, or a substituted or unsubstituted C5-C20 aryl; and
n, m, and q are simultaneously or independently 0, 1, or 2.

US Pat. No. 10,112,884

ASYMMETRICAL HYDROGENATION REACTION OF KETONIC ACID COMPOUND

1. A preparation method of the structure of formula B,
Wherein R1 is a phenyl, a substituted phenyl, a naphthyl, a substituted naphthyl, a C1-C6 alkyl or aralkyl, the substitute is a C1-C6alkyl, a C1-C6 alkoxy, a halogen, the number of the substituents is 1-3
Wherein M is the following structure chiral spiro-pyridylamidophosphine ligand iridium complex:

Wherein R is hydrogen, 3-methyl, 4-tBu or 6-methyl,
The said base is selected from sodium hydroxide, potassium hydroxide, sodium tert-butyl oxide or potassium test-butyl oxide,
The molar dosage ratio of the said base to the substrate A compound is (1.0˜3):1.

US Pat. No. 10,112,882

USE OF NOVEL CYCLIC CARBALDEYDES AS AN AROMATIC SUBSTANCE

BASF SE, Ludwigshafen am...

1. A carbaldehyde of the formula X
wherein A is a cycloaliphatic, monocyclic unsubstituted hydrocarbon radical, the carbaldehyde selected from isomeric formulae I, II or III,
and the stereoisomeric forms thereof.

US Pat. No. 10,112,877

PROCESS FOR OLEFIN PRODUCTION BY METATHESIS AND REACTOR SYSTEM THEREFOR

Borealis AG, Vienna (AT)...

1. A process for obtaining propene from at least two olefins as starting materials by metathesis, wherein one olefin is ethene and the other olefin is n-butene, comprising at least two reaction pathways, whereinin at least one first reaction pathway at least one stream comprising ethene and n-butene as starting material is fed to at least one first pre-bed reactor with at least one pre-bed comprising magnesium oxide effecting isomerisation of n-butene, and
the stream leaving the at least one first pre-bed reactor is subsequently fed to at least one main catalyst bed reactor downstream of the at least one first pre-bed reactor comprising at least one main catalyst bed comprising at least one first catalyst component comprising tungsten oxide supported on silica, and at least one second catalyst component comprising magnesium oxide, whereby the first and second catalyst are physically mixed with each other,
wherein
in at least one second reaction pathway the at least one stream comprising ethene and n-butene as starting material is re-directed from the at least one first pre-bed reactor to at least one second pre-bed reactor with at least one pre-bed comprising magnesium oxide effecting the isomerisation of the olefin, and
the stream leaving the at least one second pre-bed reactor is subsequently fed to the at least one main catalyst bed reactor downstream of the at least one second pre-bed reactor,
wherein an operational temperature of the first pre-bed reactor and an operational temperature of the second pre-bed reactor are in a range between 150° C. and 350° C. and are lower than an operational temperature of the main catalyst bed reactor, and
wherein the mass ratio of the pre-bed in the first pre-bed reactor and the second pre-bed reactor to the main catalyst bed in the main catalyst bed reactor is between 1:5 and 1:2.

US Pat. No. 10,112,875

METHOD FOR PROTECTING A HYBRID CERAMIC STRUCTURE FROM MOISTURE ATTACK IN A HIGH TEMPERATURE ENVIRONMENT

SIEMENS ENERGY, INC., Or...

1. A method for protecting a hybrid ceramic structure from moisture attack in a high temperature combustion environment containing moisture, the hybrid ceramic structure comprising a ceramic matrix composite substrate and a thermal insulation material disposed on the substrate, the method comprising:processing the hybrid ceramic structure to be in a bisque condition that provides a degree of porosity to the hybrid ceramic structure;
applying a vapor resistant material through surfaces of the thermal insulation material and the ceramic matrix composite substrate while the hybrid ceramic structure is in the bisque condition;
as a result of the degree of porosity provided by the bisque condition, infiltrating the vapor resistant material through interstices available within a thickness of the hybrid ceramic structure; and
sintering the hybrid ceramic structure to a fully sintered condition.

US Pat. No. 10,112,874

METHOD FOR COATING METAL NANOPARTICLES ON OXIDE CERAMIC POWDER SURFACE

Hohai University, Nanjin...

1. A method for coating metal nanoparticles on an oxide ceramic surface, comprising the following steps of:(1) blending oxide ceramic powder and a metal organic material according to a weight ratio of (1:1)-(10:1), obtaining blended powders through grinding and mixing the materials for 1-3 h, putting the grinded and blended powder into a rotational reactor, and starting up the rotational reactor to make the rotational reactor rotate, wherein the metal organic material is a stable organometallic compound formed by bonding an alkyl group or an alkyl of an aryl with a metal atom;
(2) bubbling mixed gas of oxygen and argon into the rotational reactor, keeping the temperature for 0.5-2 h after warming up to 400-500° C. at a rate of 5-10° C./min to oxidize the metal organic material into a metal oxide, and then closing a gas inlet valve for oxygen and argon; and
(3) bubbling reducing gas into the rotational reactor to reduce the metal oxide in step (2) into nanoparticles in a metallic state, cooling at a rate of 5-10° C./min, closing a gas inlet valve for reducing gas after cooling the temperature to room temperature, stopping the rotation of the rotational reactor, opening the reactor, taking the powder out, sieving and collecting the powder.

US Pat. No. 10,112,872

COMPOSITION FOR FORMING MN AND NB CO-DOPED PZT-BASED PIEZOELECTRIC FILM

MITSUBISHI MATERIALS CORP...

1. A composition for forming a Mn and Nb co-doped PZT-based piezoelectric film used for forming a PZT-based piezoelectric film formed of Mn and Nb co-doped composite metal oxides, the composition comprising:PZT-based precursors containing metal atoms configuring the composite metal oxides;
acetylacetone as a stabilizer; and
a diol as a solvent,
wherein the PZT-based precursors are contained in the composition so that a metal atom ratio (Pb:Mn:Nb:Zr:Ti) in the composition satisfies (1.00 to 1.25):(0.002 to 0.056):(0.002 to 0.056):(0.40 to 0.60):(0.40 to 0.60),
a rate of Mn is from 0.20 to 0.80 when the total of metal atom rates of Mn and Nb is 1,
a rate of Zr is from 0.40 to 0.60 when the total of metal atom rates of Zr and Ti is 1, and
the total rate of Zr and Ti is from 0.9300 to 0.9902 when the total of metal atom rates of Mn, Nb, Zr, and Ti is 1,
the diol is propylene glycol or ethylene glycol,
an amount of acetylacetone contained in the composition is from 0.5 moles to 4 moles when the total amount of Mn, Nb, Zr, and Ti contained in the composition is 1 mole, and
a rate of the diol in 100 mass % of the composition is from 16 mass % to 56 mass %.

US Pat. No. 10,112,863

FLOAT GLASS AND METHOD OF MANUFACTURING THE SAME

SAMSUNG DISPLAY CO., LTD....

1. A float glass comprising:a core layer;
an upper ion exchange layer disposed on the core layer; and
a lower ion exchange layer disposed below the core layer,
wherein a density of the upper ion exchange layer is about 0.001 kilogram per cubic meter to about 0.01 kilogram per cubic meter greater than a density of the lower ion exchange layer, and
wherein a difference between a depth of layer of the upper ion exchange layer and a depth of layer of the lower ion exchange layer ranges from about 0.01 micrometer to about 1.0 micrometer.

US Pat. No. 10,112,862

APPARATUS AND METHOD OF MANUFACTURING COMPOSITE GLASS ARTICLES

CORNING INCORPORATED, Co...

1. A method comprising:supplying a conjoined molten glass stream to an overflow distributor, a cross-section of the conjoined molten glass stream comprising a first cross-sectional portion and a second cross-sectional portion, the first cross-sectional portion comprising a first glass composition, the second cross-sectional portion comprising a second glass composition different than the first glass composition;
flowing the first glass composition over a first transverse segment of a weir of the overflow distributor; and
flowing the second glass composition over a second transverse segment of the weir of the overflow distributor,
wherein at least one of the first transverse segment of the weir or the second transverse segment of the weir comprises less than an entire effective width of the weir.

US Pat. No. 10,112,861

METHOD OF MANUFACTURING A PLURALITY OF GLASS MEMBERS, A METHOD OF MANUFACTURING AN OPTICAL MEMBER, AND ARRAY OF GLASS MEMBERS IN A GLASS SUBSTRATE

Infineon Technologies AG,...

1. A method of manufacturing a plurality of glass members, the method comprising:bringing a first main surface of a glass substrate in contact with a first working surface of a first mold substrate, the first working surface being provided with a plurality of first protruding portions;
bringing a second main surface of the glass substrate in contact with a second working surface of a second mold substrate, the second working surface being provided with a plurality of second protruding portions;
controlling a temperature of the glass substrate to a temperature above a glass-transition temperature to form the plurality of glass members;
removing the first and the second mold substrates from the glass substrate; and
separating adjacent ones of the plurality of glass members,
wherein controlling the temperature of the glass substrate causes the glass substrate to conform to the first and second working surfaces of the first and second mold substrates, respectively, such that:
a plurality of depressions is formed in the first main surface of the glass substrate, each of the depressions extending towards the second main surface and disposed between thicker sections of the glass substrate; and
a plurality of kerfs is formed in the second main surface of the glass substrate, each of the kerfs extending towards the first main surface and disposed within the thicker sections of the glass substrate,
wherein a thickness of the thicker sections is locally minimized by each of the kerfs.

US Pat. No. 10,112,856

METHOD AND APPARATUS FOR WASTEWATER TREATMENT USING GRAVIMETRIC SELECTION

Hampton Roads Sanitation ...

1. A method for wastewater treatment, comprising:feeding wastewater to an input of a processor that carries out a treatment process on the wastewater;
treating the wastewater in the processor;
outputting processed wastewater at an output of the processor;
feeding the processed wastewater to an input of a gravimetric selector;
selecting, at the gravimetric selector, first solids exhibiting a sludge volume index (SVI) of less than about 120 mL/gm;
outputting a recycle stream at a first output of the gravimetric selector;
outputting a waste stream that comprises solids other than said first solids at a second output of the gravimetric selector to solids handling, where solids handling includes at least one of thickening, stabilizing, conditioning, and dewatering; and
supplying the recycle stream to the processor,
wherein the feeding of the processed wastewater to the input of the gravimetric selector comprises:
feeding the processed wastewater to an input of a separator that separates the wastewater into an underflow and effluent,
receiving the underflow from the separator, and
gravimetrically selecting the first solids from the underflow and supplying the recycle stream to the first output.

US Pat. No. 10,112,855

BIOFILTRATION WITH ENHANCED SLUDGE HANDLING

6. A method of constructing a water treatment system comprising the steps of:a. providing a floating media filter comprising (i) a filter chamber having a volume to accommodate filter media, and (ii) a sludge outlet;
b. providing a sludge concentration/storage basin comprising (i) at least one wall separating the sludge basin from the floating media filter chamber; and (ii) a sludge inlet;
c. connecting the sludge outlet of the floating media filter to the sludge inlet of the storage basin via a sludge line such that fluid is moved through the sludge line by a backwash cycle of the media filter without a pump or closeable valve interfacing with the sludge line;
d. providing a charge chamber for storing air, the charge chamber including: (i) an air outlet for admitting air into the filter chamber; and (ii) an air inlet;
e. fluidly connecting the charge chamber to the filter chamber; and
f. providing a trigger for selectively allowing the passage of air through the air outlet of the charge chamber.

US Pat. No. 10,112,852

RDPREHEATING WATER JACKETS

RDP Technologies, Inc., ...

1. An apparatus for producing slaked lime slurry comprising:a programmable control system;
a slaking vessel having at least one support location that is provided with at least one load cell, wherein the load cell provides a load cell signal indicative of a total weight of the slaking vessel and its contents, said load cell communicating with said programmable control system such that said load cell signal can be received by said programmable control system;
slaking vessel temperature sensing means for sensing the temperature of the contents of said slaking vessel, wherein said slaking vessel temperature sensing means provides a slaking vessel temperature signal indicative of the temperature of the contents of said slaking vessel, said slaking vessel temperature sensing means communicating with said programmable control system such that said slaking vessel temperature signal can be received by said programmable control system;
means for charging water into the slaking vessel, said programmable control system communicating with said means for charging water into the slaking vessel, said programmable control system stopping the charging of water into said slaking vessel when said load cell signal indicates that a predetermined weight of water has been charged into said slaking vessel, wherein the water charged into said slaking vessel has a temperature;
means for mixing the content of said slaking vessel;
water temperature control means for controlling the temperature of the water charged into said slaking vessel, said water temperature control means communicating with said programmable control system, said programmable control system controlling said water temperature control means such that the temperature of the water charged into said slaking vessel is within a predetermined water temperature range;
means for charging lime feed stock into the slaking vessel, said programmable control system communicating with said means for charging lime feed stock into the slaking vessel, said programmable control system stopping the charging of lime feed stock into said slaking vessel when said load cell signal indicates that a predetermined weight of lime feed stock has been charged into said slaking vessel, thereby allowing a slaking reaction to take place; and
means for discharging the contents of said slaking vessel; said programmable control system communicating with said means for discharging the contents of said slaking vessel, said programmable control system monitoring the temperature of the contents of said slaking vessel using said slaking vessel temperature signal, said programmable control system operating said means for discharging the contents of said slaking vessel to discharge the contents of said slaking vessel when the temperature of the contents of said slaking vessel remains within a predetermined temperature range for a predetermined period of time.

US Pat. No. 10,112,849

SYSTEM AND METHOD FOR TREATING CONTAMINATED WASTEWATER

Robert Bosch GmbH, Stutt...

1. A system for treating contaminated wastewater from a buffer tank (1), comprising a feed line (3) that leads into a separator (5) and a discharge line (10) that leaves the separator (5), wherein the discharge line (10) leads into a working tank (11), wherein an access line (16) extends from the working tank (11) into a filtration system (18) which has a permeate outlet line (19) and a concentrate outlet line (17), wherein the buffer tank (1) is connected to the feed line (3) via an inlet check valve (2), wherein the permeate outlet line (19) is connected to the feed line (3) in a controllable manner in order to feed permeate back to the feed line (3), wherein the working tank (11) is connected to the feed line (3) via a return line (13), wherein a return check valve (12) is arranged in the return line (13), wherein the concentrate outlet line (17) extends from the filtration system (18) and into the working tank (11), wherein the permeate outlet line (19) is connected to the working tank (11) via a return flow line (26), wherein the system includes a heavy metal analyzer (22) in communication with the permeate outlet line (19), and wherein a precipitant line (14) opens into the feed line (3) downstream of the return line (13).

US Pat. No. 10,112,848

EMULSION EXTRACTION AND PROCESSING FROM AN OIL/WATER SEPARATOR

ExxonMobil Upstream Resea...

1. A method of emulsion extraction and processing from a subsea oil/water separator, comprising:detecting an emulsion level in the subsea oil/water separator, or detecting a composition of an emulsion stream leaving the subsea oil/water separator;
combining the emulsion stream with a first portion of a liquid/liquid jet pump discharge stream to create a diluted emulsion;
dynamically adjusting a dilution of the diluted emulsion by adding comparatively more or less of the first portion of the liquid/liquid jet pump discharge stream to the emulsion stream or vice versa, and wherein the dilution is controlled at least in part based on the emulsion level in the subsea oil/water separator or a composition of the emulsion stream;
passing at least a portion of the diluted emulsion to the liquid/liquid jet pump;
passing a recycle stream to the liquid/liquid jet pump;
combining the recycle stream and the at least a portion of the diluted emulsion in the liquid/liquid jet pump to create the liquid/liquid jet pump discharge stream;
separating a second portion of the liquid/liquid jet pump discharge stream into a water underflow stream comprising water and a reject stream comprising oil; and
passing at least a portion of the water underflow stream to the liquid/liquid jet pump, as the recycle stream, via a recirculation line.

US Pat. No. 10,112,846

SYSTEM AND METHOD FOR PRODUCING HIGH-PURITY VANADIUM TETRAOXIDE POWDER

INSTITUTE OF PROCESS ENGI...

1. A system for producing high-purity vanadium tetraoxide powder, comprising a feeding device, a low temperature chlorination fluidized bed, a rectification and purification device, a gas phase hydrolyzation fluidized bed, a high-purity vanadium pentoxide feeding device, a reduction fluidized bed, a tail gas washing absorber, an induced draft fan and a chimney;wherein the feeding device comprises an industrial grade vanadium pentoxide hopper, an industrial grade vanadium pentoxide screw feeder, a carbon powder hopper and a carbon powder screw feeder;
the low temperature chlorination fluidized bed comprises a chlorination bed feeder, a chlorination fluidized bed body, a chlorination bed cyclone separator, a flue gas heat exchanger, a flue gas condenser, a chlorination bed acid-seal tank and a chlorination bed spiral slag-discharging device;
the rectification and purification device comprises a distilling still, a rectifying column, a distillate condenser, a reflux liquid collecting tank, a silicon-containing vanadium oxy-trichloride storage tank, a rectification section acid-seal tank, a high-purity vanadium oxytrichloride condenser, and a high-purity vanadium oxytrichloride storage tank;
the gas phase hydrolyzation fluidized bed comprises a hydrolyzation bed air purifier, a hydrolyzation bed gas heater, a vanadium oxytrichloride nozzle, a gas phase hydrolyzation fluidized bed body, a hydrochloric acid tail gas absorber, and a high-purity vanadium pentoxide discharger;
the high-purity vanadium pentoxide feeding device comprises a high-purity vanadium pentoxide hopper and a high-purity vanadium pentoxide screw feeder;
the reduction fluidized bed comprises a reduction bed nitrogen gas purifier, a reduction bed gas heater, a reduction bed feeder, a reduction fluidized bed body, a reduction bed cyclone separator and a high-purity vanadium tetraoxide hopper;
wherein a feed outlet at the bottom of the industrial grade vanadium pentoxide hopper is connected with a feed inlet of the industrial grade vanadium pentoxide screw feeder; a feed outlet at the bottom of the carbon powder hopper is connected with a feed inlet of the carbon powder screw feeder; and a feed outlet of the industrial grade vanadium pentoxide screw feeder and a feed outlet of the carbon powder screw feeder are both connected with a feed inlet of the chlorination bed feeder through a pipeline;
a feed discharge opening of the chlorination bed feeder is connected with a feed inlet at the upper part of the chlorination fluidized bed body through a pipeline; a gas inlet at the bottom of the chlorination bed feeder is connected with a nitrogen gas source main pipe through a pipeline; the chlorination bed cyclone separator is provided at the center of the top of the expansion section of the chlorination fluidized bed body; a gas outlet at the top of the chlorination bed cyclone separator is connected with a hot flue gas inlet of the flue gas heat exchanger through a pipeline; a cold flue gas outlet of the flue gas heat exchanger is connected with a gas inlet of the flue gas condenser through a pipeline; a gas outlet of the flue gas condenser is connected with a gas inlet of the chlorination bed acid-seal tank through a pipeline; a gas outlet of the chlorination bed acid-seal tank is connected with a gas inlet of the tail gas washing absorber through a pipeline; a slag-discharge opening at the lower part of the chlorination fluidized bed body is connected with a feed inlet of the chlorination bed spiral slag-discharging device through a pipeline; a gas inlet at the bottom of the chlorination fluidized bed body is connected with a hot gas outlet of the flue gas heat exchanger through a pipeline; and a cold gas inlet of the flue gas heat exchanger is connected with a chlorine gas source main pipe, the nitrogen gas source main pipe and a compressed air main pipe through pipelines, respectively;
a liquid outlet at the bottom of the flue gas condenser is connected with a feed inlet of the rectifying column through a pipeline; a steam outlet of the distilling still is connected with a steam inlet of the rectifying column through a pipeline; a backflow inlet of the distilling still is connected with a liquid reflux outlet at the bottom of the rectifying column through a pipeline; a gas outlet at the top of the rectifying column is connected with a gas inlet of the distillate condenser through a pipeline; a liquid outlet of the distillate condenser is connected with a liquid inlet of the reflux liquid collecting tank through a pipeline; a reflux liquid outlet of the reflux liquid collecting tank is connected with a reflux liquid inlet at the top of the rectifying column through a pipeline; a feed discharge opening of the reflux liquid collecting tank is connected with an inlet of the silicon-containing vanadium oxytrichloride storage tank through a pipeline; an exhaust gas outlet of the silicon-containing vanadium oxytrichloride storage tank is connected with a gas inlet of the rectification section acid-seal tank through a pipeline; a gas outlet of the rectification section acid-seal tank is connected with a gas inlet of the tail gas washing absorber through a pipeline; a rectificate outlet of the rectifying column is connected with a gas inlet of the high-purity vanadium oxytrichloride condenser through a pipeline; a liquid outlet of the high-purity vanadium oxytrichloride condenser is connected with a liquid inlet of the high-purity vanadium oxytrichloride storage tank through a pipeline; and an underflow outlet is provided at the bottom of the distilling still;
a gas inlet of the hydrolyzation bed air purifier is connected with the compressed air main pipe through a pipeline; a gas outlet of the hydrolyzation bed air purifier is connected with a gas inlet of the hydrolyzation bed gas heater, a gas inlet of the vanadium oxytrichloride nozzle, and a gas inlet at the bottom of the high-purity vanadium pentoxide discharger through pipelines, respectively; a combustion-supporting wind inlet and a fuel inlet of a combustion nozzle of the hydrolyzation bed gas heater are respectively connected with the compressed air main pipe and a fuel main pipe through pipelines; the gas inlet of the hydrolyzation bed gas heater is connected with a ultrapure water main pipe through a pipeline; a gas outlet of the hydrolyzation bed gas heater is connected with a gas inlet at the bottom of the gas phase hydrolyzation fluidized bed body through a pipeline; a liquid outlet of the high-purity vanadium oxytrichloride storage tank is connected with a vanadium oxytrichloride inlet of the vanadium oxytrichloride nozzle through a pipeline; a gas outlet at the top of the expansion section of the gas phase hydrolyzation fluidized bed body is connected with a gas inlet of the hydrochloric acid tail gas absorber through a pipeline; a hydrochloric acid solution outlet is provided at the bottom of the hydrochloric acid tail gas absorber; a gas outlet of the hydrochloric acid tail gas absorber is connected with a gas inlet of the tail gas washing absorber through a pipeline; a feed outlet at the upper part of the gas phase hydrolyzation fluidized bed body is connected with a feed inlet of the high-purity vanadium pentoxide discharger through a pipeline; and a feed discharge opening of the high-purity vanadium pentoxide discharger is connected with a feed inlet of the high-purity vanadium pentoxide hopper through a pipeline;
a feed outlet at the bottom of the high-purity vanadium pentoxide hopper is connected with a feed inlet of the high-purity vanadium pentoxide screw feeder; and a feed discharge opening of the high-purity vanadium pentoxide screw feeder is connected with a feed inlet of the reduction bed feeder through a pipeline;
a gas inlet of the reduction bed nitrogen gas purifier is connected with the nitrogen gas source main pipe through a pipeline; a gas outlet of the reduction bed nitrogen gas purifier is connected with a gas inlet of the reduction bed gas heater and a gas inlet at the bottom of the reduction bed feeder through pipelines, respectively; a combustion-supporting wind inlet and a fuel inlet of a combustion nozzle of the reduction bed gas heater are respectively connected with the compressed air main pipe and the fuel main pipe through pipelines; a gas inlet of the reduction bed gas heater is connected with a high-purity hydrogen main pipe through a pipeline; a gas outlet of the reduction bed gas heater is connected with a gas inlet at the bottom of the reduction fluidized bed body through a pipeline; a feed discharge opening of the reduction bed feeder is connected with a feed inlet at the lower part of the reduction fluidized bed body through a pipeline; the reduction bed cyclone separator is provided at the center of the top of the expansion section of the reduction fluidized bed; a gas outlet of the reduction bed cyclone separator is connected with the tail gas treatment unit through a pipeline; and a feed discharge opening at the upper part of the reduction fluidized bed body is connected with a feed inlet of the high-purity vanadium tetraoxide hopper through a pipeline;
a gas outlet of the tail gas washing absorber is connected with a gas inlet of the induced draft fan through a pipeline; and a gas outlet of the induced draft fan is connected with a gas inlet at the bottom of the chimney through a pipeline.

US Pat. No. 10,112,842

PROCESS TO PRODUCE MAGNESIUM COMPOUNDS, AND VARIOUS BY-PRODUCTS USING SULFURIC ACID IN A HCL RECOVERY LOOP

1. A process for extracting magnesium sulfate from magnesium-bearing ores, comprising the steps of:(a) leaching the magnesium-bearing ores with HCl to obtain a slurry containing chloride compounds;
(b) filtering the slurry to obtain a liquor containing the chloride compounds and silica;
(c) purifying the liquor by increasing the pH by adding a neutralizing agent to produce a brine chloride solution enriched in magnesium containing precipitated iron and impurities;
(d) filtering the brine chloride solution to extract the precipitated iron and impurities;
(e) neutralizing the brine chloride solution to extract nickel by adding a base, to produce an enriched magnesium chloride brine; and
(f) adding the enriched magnesium chloride brine to sulfuric acid to form magnesium sulfate and hydrochloric acid.

US Pat. No. 10,112,837

CARBON ALLOTROPES

Lyten, Inc., Sunnyvale, ...

1. A carbon aggregate comprising:at least two connected multi-walled spherical fullerenes; and
layers of graphene coating the connected multi-walled spherical fullerenes.

US Pat. No. 10,112,833

METHOD FOR PREPARING ALUMINUM NITRIDE

NATIONAL TSING HUA UNIVER...

1. A method for preparing aluminum nitride, consisting of steps of:(a) injecting a nitrogen-containing gas and a pure aluminum material into a pulverizing chamber operating in vacuum in a high-temperature jet mill by a high-pressure air to form a high-speed airflow;
(b) melting the pure aluminum material into a liquid status of the pure aluminum in the pulverizing chamber in the high-temperature jet mill;
(c) allowing the liquid status of the pure aluminum material to react with the nitrogen and form aluminum nitride on the surface of the pure aluminum material in the pulverizing chamber in the high-temperature jet mill;
(d) pulverizing the formed aluminum nitride into aluminum nitride powder and removing the aluminum nitride powder from the surface of the pure aluminum material by the high-speed airflow in the pulverizing chamber in the high-temperature jet mill;
(e) exposing the remaining liquid status of the pure aluminum material to the nitrogen-containing gas in the pulverizing chamber in the high-temperature jet mill; and
(f) repeating steps (c) to (e) in the pulverizing chamber in the high-temperature jet mill until all the liquid status of the pure aluminum material is completely consumed.

US Pat. No. 10,112,830

SHAPED CATALYST FOR SOUR GAS SHIFT REACTIONS AND METHODS FOR USING THEM

Clariant Corporation, Lo...

1. A catalyst material in the shape of an annular solid, the annular solid having a cross-sectional shape havinga lateral outer surface;
a single hole in the annular solid, the hole defining a lateral inner surface of the annular solid, the lateral outer surface and the lateral inner surface defining an annular wall, wherein the annular wall has a minimum wall thickness in the range of 1.5 mm to 3 mm;
an average width in the range of about 3.3 mm to about 10 mm as measured through the geometrical center of the cross-sectional shape of the solid; and
a length measured in a direction parallel to the hole, the length being in the range of about 2 mm to about 30 mm;
wherein the minimum ratio of wall thickness to width measured along the line of the wall thickness is at least about 0.3 to about 0.45,
wherein the catalyst material comprises one or more catalytically-active metal species, the catalytically-active metal species including cobalt and molybdenum species,
wherein the catalyst material comprises a carrier material that is aluminum oxide or aluminum oxide in combination with magnesium oxide, wherein the carrier material is at least about 75% aluminum oxide, and
wherein the catalyst material has a BET surface area of about 50 to about 400 m2/q.

US Pat. No. 10,112,826

METHOD FOR FORMING MICRO-ELECTRO-MECHANICAL SYSTEM (MEMS) DEVICE STRUCTURE

Taiwan Semiconductor Manu...

1. A method for forming a micro-electro-mechanical system (MEMS) device structure, comprising: forming a recess in a first substrate; depositing a dielectric layer on the first substrate and filling the recess, wherein an entirety of the dielectric layer has a substantially planar top surface; bonding a second substrate on the dielectric layer, wherein an entire bottom surface of the second substrate is in direct contact with the substantially planar top surface of the dielectric layer; etching a portion of the second substrate to form a MEMS structure, wherein the MEMS structure has a plurality of openings; and etching a portion of the dielectric layer to form a cavity below the openings.

US Pat. No. 10,112,822

SEMICONDUCTOR DEVICE

TAIWAN SEMICONDUCTOR MANU...

1. A method, comprising:bonding a first substrate to a second substrate, wherein a microelectromechanical systems (MEMS) structure is in a space between the first substrate and the second substrate;
etching the second substrate to form at least one through hole;
forming a first metal layer over the second substrate;
forming an anti-stiction layer on a surface of the MEMS structure and the first metal layer;
removing the anti-stiction layer from the first metal layer by performing a thermal treatment to the first metal layer; and
sealing the at least one through hole of the second substrate.

US Pat. No. 10,112,818

LIQUID DISPENSING TAP AND CLOSURE ASSEMBLY THEREFOR

Scholle IPN Corporation, ...

1. A liquid dispensing tap comprising:a body having an inner cavity, with an inlet configured to be attached to a spout in fluid tight engagement, an outlet spaced apart from the inlet and an actuator assembly having a user actuatable control button and a manipulating rod extending into the inner cavity; and
a closure assembly positionable within the inner cavity of the body, the closure assembly further comprising:
a stirrup attached to the body in fixed engagement, the stirrup defining a stirrup plane, the stirrup including a first spring mounting brace on a first side of the stirrup, and a second spring mounting brace on a second side of the stirrup, the first spring mounting brace and the second spring mounting brace being oblique to the stirrup plane and extending from a top surface of the stirrup;
a closure member having an actuator engagement structure slidably engageable with the manipulating rod, and an plug member structurally configured to be engageable with the outlet in sealed engagement, the closure member movable along a closure axis, the closure axis being substantially perpendicular to the stirrup plane; and
a spring assembly biasing the closure member into sealed engagement with the outlet, comprising a first spring and a second spring, the first spring having a first end extending from a first side of the closure member and a second end extending from the first spring mounting brace, the first spring member having an inner leg region and an outer leg region substantially parallel to the inner leg region, with a central curved region therebetween, with the inner region being substantially perpendicular to the first spring mounting brace, and the second spring having a first end extending from a second side of the closure member and a second end extending from the second spring mounting brace, the second spring member having an inner leg region and an outer leg region substantially parallel to the inner leg region, with a central curved region therebetween, with the inner region being substantially perpendicular to the second spring mounting brace.

US Pat. No. 10,112,815

HIGH REACH LIFTING BIG BALE FORK ATTACHMENT

1. A high reach lifting big bale fork attachment for a wheel loader or other bale handling equipment comprising: a rear coupler and slide assembly, slidably attached to a sliding mast assembly, said mast assembly slidably attached to a front bale rack assembly; a plurality of actuators operatively connected to and between said slide assembly and said mast assembly, a plurality of actuators operatively connected to and between said mast assembly and said front bale rack assembly, and a loader attachment adapter attached to said rear coupler and slide assembly wherein said rear coupler and slide assembly further comprising a straight C-channel; said sliding mast assembly further comprising a mast I-beam having a straight rear rail and a convex arced front rail, said rear rail and said front rail joined together by an I-web bridging member; said front bale rack assembly further comprising a front concave arced C-channel; and said straight C-channel slidingly receives and retains said straight rear rail, and said front concave arced C-channel slidingly receives and retains said arced front rail.

US Pat. No. 10,112,805

PALLET-PULLING DEVICE

1. A pallet-pulling device comprising:a skid puller, a bridle chain, and a clevis grab hook;
wherein the pallet-pulling device is used to pull a pallet out of an elevated shipping container;
wherein the skid puller comprises a plurality of ribs, a backing plate, a pull plate, a bolt, and a nut;
wherein the skid puller is coupled to the pallet by hooking a leading edge of the pull plate behind an upper board on the pallet;
wherein the skid puller is decoupled from the pallet by lifting the bridle chain and allowing the pull plate to drop from behind the upper board.

US Pat. No. 10,112,804

ESCALATOR SYSTEM

KONE CORPORATION, Helsin...

1. An escalator system, wherein the escalator system is configured to:drive an escalator, via a control unit, in response to a signal received from a user interface located in a first pit in a first end of the escalator; and
stop movement of the escalator in response to detection, via a detector, of opening of an access cover plate covering a second pit in a second end of the escalator, wherein the detector communicates the detection to the control unit,
wherein the detector is electrically connected to the control unit,
wherein the detector is configured to detect whether the access cover plate in the second end of the escalator is open or closed, and
wherein the escalator system is configured to, after said stop, in response to signals received from said user interface, activate an inspection mode, to continue driving the escalator irrespective of whether the access cover plate in the second end of the escalator is open or closed during the continued driving.

US Pat. No. 10,112,803

PROTECTION ASSEMBLY FOR ELEVATOR BRAKING ASSEMBLY SPEED SENSING DEVICE AND METHOD

OTIS ELEVATOR COMPANY, F...

1. A brake assembly for an elevator system comprising:a guide rail configured to guide movement of an elevator car;
a safety brake operatively coupled to the elevator car and having a brake surface configured to frictionally engage the guide rail; and
a safety brake actuation mechanism operatively coupled to the safety brake and configured to actuate the brake member to a braking position, the safety brake actuation mechanism comprising:
a sensing device disposed at a distance from the guide rail to determine a speed of the elevator car relative to the guide rail; and
a first rigid plate having an inner edge disposed at a distance from the guide rail that is less than the distance that the sensing device is spaced from the guide rail, said first rigid plate configured to prevent the sensing device from contacting debris disposed on the guide rail.

US Pat. No. 10,112,802

ELEVATOR SERVICE PERSON COLLISION PROTECTION SYSTEM

OTIS ELEVATOR COMPANY, F...

1. An elevator car collision protection system comprising:a first antenna configured to be worn by a person entering a hoistway;
a first trio of transceivers located a first selected distance away from a first impact wall of the hoistway, the first trio of transceivers being configured to detect a first clearance between an elevator car within the hoistway and the first trio of transceivers and a second clearance between the first antenna and the first trio of transceivers; and
an alarm configured to activate when a collision risk level exceeds a selected risk level, wherein the collision risk level is determined in response to the first clearance and the second clearance.

US Pat. No. 10,112,801

ELEVATOR INSPECTION APPARATUS WITH SEPARATE COMPUTING DEVICE AND SENSORS

1. An elevator inspection apparatus, comprising:a commercially available off-the-shelf computing device comprising a computing processor for running computer programs, an electronic memory used by said computing processor while running a computer program, an electronic storage for indefinitely storing data files and computer programs, an electronic display for displaying graphics to a user, a power source, and an interface for communicating with and providing power to a physically separate sensor package;
a sensor package, physically separate from said computing device, comprising a sensor for measuring the acceleration of the elevator car, a door sensor for determining the position of the elevator door, an altimeter for measuring the altitude of the elevator car, and an interface for communicating with and receiving power from said computing device;
a communication mechanism between said computing device and said sensor package whereby said communication mechanism provides two-way communications between said computing device and said sensor package, and said communication mechanism provides power from said computing device to said sensor package;
a computer program stored in said electronic storage and running in said computing processor that repetitively requests acceleration measurements, door positions, and altitude measurements from said sensor package and analyzes said acceleration measurements, door positions, and altitude measurements, and manages the functions of said elevator inspection apparatus;
whereby said computer program computes the beginnings and ends of every trip of the elevator car so that the user need not indicate the beginnings and ends of any trip to said elevator inspection apparatus; and said computer program computes the accelerations, velocities, jerks, door positions, landings, trip start times, trip end times, trip directions, and trip durations of the elevator car for every trip, displays the results of the computations on said electronic display, and stores the results and times of the computations for every trip in said electronic storage so that the number of results that are stored is limited only by the size of said electronic storage.

US Pat. No. 10,112,793

OPENING METHOD AND DEVICE THEREOF

1. An opening method, comprising:restraining an outer peripheral surface of a metal coil of a wound metal sheet with a plurality of restraining rolls;
disposing an opening blade body and contacting a blade tip of the opening blade body onto the outer peripheral surface of the metal coil;
rotating the metal coil in an opposite direction to a take-up direction of the metal coil to insert the blade tip inside the metal sheet from a leading end portion of the metal sheet to separate the leading end portion of the metal sheet from the metal coil using the opening blade body; and
continuing rotation of the metal coil in the opposite direction to support an inner peripheral surface of the metal sheet at a load action point of the metal sheet at which the inner peripheral surface of the metal sheet is supported by a supporting portion of the opening blade body using the opening blade body with the leading end portion of the metal sheet in a free state so as to satisfy the following Equation (1) and Equation (2):

wherein:
U is an opening radial direction dimension, from the load action point of the metal sheet to the outer peripheral surface of the metal coil, in mm;
K is a radial direction permissible dimension at the load action point position, from the inner peripheral surface of the metal sheet to the outer peripheral surface of the metal coil, in mm;
Yp is a yield stress of the metal sheet, in kgf/mm2;
Z is a section modulus of the metal sheet (=(?) bt2), in mm3, wherein b is a width of the metal sheet, in mm, and t is a plate thickness of the metal sheet, in mm;
R is a metal coil radius r from which one-half of the plate thickness t of the metal sheet has been subtracted (r ?(1/2 ) t), in mm;
E is a Young's modulus of the metal sheet, in kgf/mm2;
I is a second moment of area of the metal sheet, in mm4; and
? is an angle in radians about an axis of the metal coil from the load action point to a portion restrained by a nearest restraining roll of the restraining rolls that is nearest to the load action point along a rewind direction of the metal coil.

US Pat. No. 10,112,792

BANKNOTE HANDLING APPARATUS

GLORY LTD., Himeji-shi (...

1. A banknote handling apparatus that performs at least one of a banknote depositing process and a dispensing process and transports a banknote along a transport path, comprising:at least one transport member that is slidable along a widthwise direction of the transport path and transports the banknote in both forward and reverse directions along the transport path;
a banknote detection unit that detects a position of the banknote in the widthwise direction of the transport path; and
a control unit that calculates an amount of movement of the at least one transport member based on a position of the banknote in the widthwise direction of the transport path detected by the banknote detection unit and performs a control so as to slide the at least one transport member by the calculated movement amount when the banknote is transported by the at least one transport member, wherein
the at least one transport member is arranged in at least one first guide portion that constitutes the transport path,
the at least one first guide portion is slidable along the widthwise direction of the transport path integrally with the at least one transport member,
the at least one first guide portion comprises a pair of first guide portions arranged so as to be separated from each other, in which the transport path is formed between the pair of first guide portions, and
the pair of first guide portions is slidable such that a first distance between the pair of first guide portions on an inlet of the transport path arranged between the pair of first guide portions and a second distance between the pair of first guide portions on an outlet thereof are respectively changed.

US Pat. No. 10,112,788

SWEEP AUGER APPARATUS

Mid-Columbia Producers, ...

1. A sweep auger apparatus, comprising:an attachment plate having a first side and a second side, the first side having attachment features to removably attach the attachment plate to mobile equipment;
a first rotatable shaft secured to the second side of the attachment plate, a central axis of the first rotatable shaft extending in a first direction;
a first motor connected to the first rotatable shaft to cause the first rotatable shaft to rotate;
an auger support member connected to the first rotatable shaft so as to rotate with a rotation of the first rotatable shaft;
a second rotatable shaft secured to the auger support member, a central axis of the second rotatable shaft extending in a second direction that is transverse to the first direction; and
a second motor connected to the second rotatable shaft to cause the second rotatable shaft to rotate, thereby rotating an auger.

US Pat. No. 10,112,786

FEEDING MEMBRANE FOR GRAVEL BLOWER

1. An article of manufacture, comprising:a gravel blower feeding tube, said gravel blower feeding tube comprising a deformable membrane, said deformable membrane comprising an elastomeric tube, said elastomeric tube having a converging portion having an inlet and a tubular portion having an outlet,
said converging portion provided in the shape of a truncated conoid,
said tubular portion having a flexible sidewall, said flexible sidewall elastically displaceable laterally a distance of at least one (1) inch.

US Pat. No. 10,112,782

MOTOR DRIVEN ROLLER SUPPORT

Dematic Corp., Grand Rap...

20. A motor driven roller support assembly comprising:a motorized roller, said motorized roller having a cylindrical outer surface with said motorized roller including an internal motor configured to provide driving rotation whereby said outer surface rotates;
a support frame, said motorized roller being mounted to said support frame; and
a roller support, said roller support including a support wheel;
wherein said support wheel engages said outer surface of said motorized roller.

US Pat. No. 10,112,775

CONVEYOR SYSTEM, OPERATING SYSTEM USING CONVEYOR SYSTEM, AND METHOD

Baker Hughes, a GE Compan...

1. An operating system comprising:a material receiving member including a blender;
a high pressure fracturing pump configured to receive hydraulic fracturing fluid from the blender; and
a conveyor system including:
a head portion;
a tail portion;
a looped belt having a conveying portion and a retreating portion movable through the conveyor system, each of the conveying portion and the retreating portion having an interior surface and an exterior surface, the exterior surface of the conveying portion configured to convey materials;
a conveying portion cover extending from the tail portion to the head portion of the conveyor system, the conveying portion of the belt disposed within the conveying portion cover, the retreating portion of the belt disposed exteriorly of the conveying portion cover from the head portion to the tail portion, the conveying portion cover having a convex sliding surface from the tail portion to the head portion and a tubular shape from the tail portion to the head portion; and
a discharge portion;
wherein the interior surface of the conveying portion of the belt is slidable along the sliding surface of the conveying portion cover from the tail portion to the head portion of the conveyor system, at least a substantial portion of the interior surface of the conveying portion of the belt contacting the sliding surface of the conveying portion cover, the conveying portion of the belt being nested within the conveying portion cover, and the conveyor system is telescopic; and material carried by the conveying portion of the belt is deposited into the material receiving member.

US Pat. No. 10,112,773

SYSTEM AND METHODS FOR ARCHIVING AND RETRIEVING SPECIMENS

University of Kansas, La...

1. A system for archiving and retrieving specimens, comprising:an archival structure including an input location and an output location, wherein the input location is the same as the output location;
at least one storage module, the at least one storage module including a plurality of receptacles configured for receiving and storing specimens, the receptacles including at least one support element;
at least one specimen movement mechanism, wherein the specimen movement mechanism is configured to move a specimen from the input location to a storage location on one receptacle of the plurality of receptacles, wherein the specimen movement mechanism is a robotic arm;
a receptacle positioning component configured to position the one receptacle of the plurality of receptacles to a location accessible by the specimen movement mechanism; and
a software program, wherein the software program is configured to receive information regarding the storage location of the specimen and store the information on a computer readable storage medium of a computer system.

US Pat. No. 10,112,767

FAN SPRAY STRUCTURE FOR USE IN DISPENSING ACTUATOR

APTARGROUP, INC., Crysta...

1. In an actuator (18) for actuating a valve (16) on a container (14) for dispensing a fluent product from the container (14), the actuator (18) including a dispensing flow path (58) to direct fluent product from the valve (16) to an exterior of the actuator (18) via an exit orifice (64) located at an end of the flow path (58), and a post (70) defining a portion of the flow path (58), the post (70) extending along and centered on a longitudinal axis (72) and having an end face (74) adjacent said exit orifice (64), an improvement comprising:a flow channel (100) extending laterally across the end face (74) of the post (70), the flow channel (100) being symmetric about a lateral axis (102) extending transverse to the longitudinal axis (72) of the post (70), a portion of the flow channel (100) directly communicating with said exit orifice (64) to direct the fluent product from the flow channel (100) into the exit orifice (64);
wherein the exit orifice (64) is symmetric about the lateral axis (102) of the post (70).

US Pat. No. 10,112,766

INTELLIGENT INSULATION CUP

1. An intelligent insulation cup, comprising: an intelligent cup cover, an insulation cup body and a wireless charging base (1); wherein the intelligent cup cover is buckled on the insulation cup body and is in wireless transmission connection with the wireless charging base (1);the intelligent cup cover is formed by fixedly connecting a skull headdress (2), a battery accommodating cavity (3) and a display cup cover (4) which are arranged from top to bottom successively, wherein a storage battery is disposed in the battery accommodating cavity (3);
the display cup cover (4) is a bowl-shaped cavity structure, and a time-temperature display dial plate (5) is disposed on an outer wall of a side surface; the time-temperature display dial plate (5) is successively provided with a hour circle (6), a minute circle (7) and a second circle (8) from top to bottom; 1-24 numerical display windows are evenly distributed on the hour circle (6); 1-60 numerical display windows are evenly distributed on the minute circle (7); 60 circular display windows are evenly distributed on the second circle (8); an annular lamp bead circuit board (9) corresponding to the time-temperature display dial plate (5) is disposed on an inner wall of the side surface of the display cup cover (4); the annular lamp bead circuit board (9) is electrically connected with three-color LED lamp beads (10) with luminous colors used to represent liquid temperature; and the three-color LED lamp beads (10) are disposed correspondingly to the display windows;
a bowl-shaped sealing barrier chip (11) and a bottom mouth plug (12) are disposed in the cavity of the display cup cover (4); a plug (13) is disposed on the top end of the bottle mouth plug (12), and a temperature sensor is disposed on the bottom; the bowl-shaped sealing barrier chip (11) is provided with a through hole corresponding to the plug (13); a jack corresponding to the plug (13) is disposed on the top end in the cavity of the display cup cover (4); the plug (13) penetrates through the through hole and is matched with the jack; the bottle mouth plug (12) is fixedly connected with the time-temperature display dial plate (5); the display cup cover (4) is buckled with the insulation cup body through the bottle mouth plug (12); the bottle mouth plug (12) is connected with the insulation cup body through a thread; and the bowl-shaped sealing barrier chip (11) is fixed to the cavity of the display cup cover (4), and the inner cavity of the display cup cover (4) and the bowl-shaped sealing barrier chip (11) form a sealing cavity for sealing the annular lamp bead circuit board (9);
a control mainboard (17) is disposed in the sealing cavity; a wireless receiving unit, a timing unit, a temperature measurement unit, a contact sensing unit and an analysis processing unit are disposed on the control mainboard (17); and the control mainboard (17) is electrically connected with the storage battery, the lamp bead circuit board (9) and the temperature sensor respectively;
the insulation cup body comprises a bottle body (18) and a bottle bottom (19); the bottle bottom (19) is fixedly connected to the bottom end of the bottle body (18); the bottle body (18) is composed of a touch-sensitive outer layer, an insulation layer and a liner successively from outside to inside; a snakelike anti-skid substance (20) is inlaid to the touch-sensitive outer layer; the touch-sensitive outer layer is electrically connected with the control mainboard (17); and a stereographic pentagram mark (21) is inlaid to the center of the cup bottom (19);
the wireless charging base (1) comprises a wireless transmission apparatus and a time adjustment apparatus (22); and the wireless transmission apparatus and the time adjustment apparatus (22) are electrically connected.

US Pat. No. 10,112,764

POUCH WITH INCORPORATED LOSS OF INTEGRITY INDICATOR, METHOD FOR MAKING SUCH A BAG, AND METHOD FOR USING SAME

SARTORIUS STEDIM FMT SAS,...

1. A method for producing a pouch with an incorporated and active loss of integrity indicator, the pouch including:a first flexible, closed, inner casing made of at least one non-porous plastic material with a high-capacity gas barrier, delimiting a first space, forming a first space pouch configured to accommodate a fluid biopharmaceutical product or device, the inner casing including
first introduction means for introducing the biopharmaceutical product or device into the first space pouch, and
first evacuation means for subsequently evacuating the biopharmaceutical product or device from the first space pouch, the first introduction means and the first evacuation means being in an inactive closed state;
a second, closed, outer casing made of at least one non-porous plastic material with a high-capacity gas barrier, delimiting a second space in which the first space pouch is located for detection of a loss of integrity of the first space pouch including
second introduction means for preliminarily introducing the first space pouch into the second space, and
second evacuation means for evacuating the first space pouch from the second space, the second introduction means and the second evacuation means being in the inactive closed state;
a spacer means interposed between the first space pouch and the second casing, an inner surface of the second casing being configured to not conceal a zone of loss of integrity of an outer surface of the first space pouch, the spacer means being or including porous material;
at least one tracer gas that is located respectively in one of the first space or in the second space, the second space being outside of the first space pouch, having a higher partial pressure than a pressure in the other of the first space and the second space; and
an incorporated loss of integrity indicator including at least one colorimetric detector that detects the at least one tracer gas, the at least one colorimetric detector being responsive to a concentration of the tracer gas in an environment in which the detector is located, by switching from a first color to a second color that is different from the first color, the at least one colorimetric detector being located in one or more of the second space outside of the first space pouch and in the first space,
the colorimetric detector being configured to visually indicate one of the first color, signifying that the first space pouch has kept its integrity, and the second color, signifying that the first space pouch has lost its integrity, after the pouch with the incorporated loss of integrity indicator is manufactured and at least before the time when the first space pouch is evacuated, extracted, or removed from the second casing and the biopharmaceutical product or device is introduced into the first space pouch, and
the colorimetric detector being configured to detect the at least one tracer gas when the first space pouch is devoid of the biopharmaceutical product or device and when the second, closed, outer casing is maintained in a closed state, the method comprising:
providing the first flexible casing made of the at least one non-porous plastic material with the high-capacity gas barrier, delimiting the first space, forming the first space pouch that can accommodate the biopharmaceutical product or device, the first flexible casing including the first introduction means and the first evacuation means;
providing the second casing made of the at least one non-porous plastic material with the high-capacity gas barrier, the second casing including the second introduction means and the second evacuation means,
providing the spacer means;
providing the at least one selected tracer gas;
providing the at least one colorimetric detector of the at least one tracer gas that is responsive to the concentration of the at least one tracer gas in the environment in which the colorimetric detector is located, by switching from the first color to the second color that is different from the first color;
introducing the first space pouch into the second casing;
interposing the spacer means between the first space pouch and the second casing in such a way that the inner surface of the second casing does not conceal the zone of possible loss of integrity of the outer surface of the inner space pouch; and
introducing the at least one selected tracer gas into the one of the first space and the second space outside of the inner space pouch, with the higher partial pressure than a pressure in the other of the first space and the second space outside of the inner space pouch, the at least one colorimetric detector of the at least one tracer gas being placed in one of the first space and the second space outside of the inner space pouch; and
closing the inner space pouch and the second casing.

US Pat. No. 10,112,755

REUSABLE CABLE TIES

1. A flexible strap comprising:wherein the flexible strap comprises a base structure, a plurality of slots, and a plurality of pegs;
wherein the plurality of slots are formed within the base structure;
wherein the plurality of pegs are attached to the base structure;
wherein the flexible strap is a self-attaching strapping apparatus;
wherein the flexible strap trusses filamentary materials together;
wherein the flexible strap forms a loop through which the filamentary materials are inserted before the flexible strap is tightened to form a truss;
wherein the reusable cable attaches to itself to form a loop in a detachable manner;
wherein the loop is further defined with a diameter and a perimeter;
wherein the diameter of the loop is adjustable;
wherein the filamentary materials are inserted through the loop;
wherein the truss is formed by adjusting the flexible strap to reduce the diameter of the loop such that the flexible strap applies a force against the filamentary materials;
wherein the base structure is a rounded rectangular strip;
wherein the base structure is formed as a strip from flexible metal strapping of constant thickness;
wherein the base structure forms the perimeter of the loop trusses the filamentary material;
wherein the loop is an enclosed ring structure that is formed by the base structure when the plurality of pegs are inserted through one or more slots selected from the plurality of slots;
wherein the loop forms the truss;
wherein the span of the diameter of the loop is adjusted through the selection of the one or more slots selected from the plurality of slots;
wherein the size of the truss is adjusted by adjusting the span of the diameter of the loop;
wherein the base structure is further defined with a length direction, a width direction, and a thickness direction;
wherein the length direction refers to the dimension of the base structure with the greatest span of distance;
wherein the width direction refers to the dimension of the base structure that is perpendicular to the length direction;
wherein the width direction combines with the length direction to form the planar surface of the base structure with the greatest surface area;
wherein the thickness direction refers to the dimension of the base structure that is perpendicular to both the length direction and the width direction;
wherein the base structure is further defined with a primary face and a secondary face;
wherein the primary face refers to the face of the base structure that is formed in the length direction and the width direction;
wherein the secondary face refers to the face of the base structure that is formed in the length direction and the width direction that is distal from the primary face;
wherein the primary face is the face of the base structure upon which the plurality of pegs are mounted;
wherein the plurality of slots comprises a plurality of rectangular block shaped negative spaces;
wherein each slot selected from the plurality of slots is identical;
wherein the negative space that forms each of the plurality of slots is formed in the thickness direction of the base structure from and through the primary face to the secondary face;
wherein each slot selected from the plurality of slots is formed with an inner dimension that is measured in the length direction and the width direction;
wherein each of the plurality of slots are positioned such that the center of each of the plurality of slots forms a straight line that is parallel to the length direction;
wherein the center to center distance in the length direction of a first set of adjacent slots selected from the plurality of slots is equal to the center to center distance in the length direction of any second set of adjacent slots selected from the plurality of slots;
wherein each of the plurality of pegs is an individual peg that projects perpendicularly away from the primary face of the base structure;
wherein each of the plurality of pegs is identical;
wherein the individual peg is formed with an outer dimension in the length direction and the width direction;
wherein each individual peg is inserted into a slot selected from the plurality of slots for the purpose of forming the loop;
wherein each individual peg selected from the plurality of pegs is positioned on the primary face of the base structure such that the center of each individual peg is aligned with the centers of the individual pegs remaining in the plurality of pegs to form a straight line that is parallel to the length direction of the base structure;
wherein the center to center distance in the length direction of a first set of adjacent individual pegs selected from the plurality of pegs is equal to the center to center distance in the length direction of any second adjacent set of individual pegs selected from the plurality of pegs;
wherein the center to center distance in the length direction of any set of adjacent individual pegs selected from the plurality of pegs is equal to an integer multiple of the center to center distance in the length direction of any set of adjacent slots selected from the plurality of slots;
wherein the integer multiple is a positive integer that is greater than or equal to one;
wherein the line formed by each of the centers of the plurality of pegs is aligned in the width direction with the line formed by the centers of each of the plurality of slots;
wherein each individual peg comprises a plate and a headpiece;
wherein the headpiece attaches to the plate;
wherein the plate is further defined with a plate height;
wherein the plate is a rectangular block structure that projects perpendicularly away from the primary face of the base structure;
wherein the plate attaches to the primary face of the base structure in the manner of a cantilever;
wherein the plate is further defined with a free end;
wherein the plate height is the span of the distance from the primary face to the free end of the plate as measured in the thickness direction.

US Pat. No. 10,112,750

BEVERAGE CONTAINER SEALING SYSTEM

Anheuser-Busch, LLC, St....

1. A sealing closure for a beverage container, comprising:a crown defining a bottom surface;
a liner comprising an oxygen scavenger coupled to the crown such that a top surface of the liner contacts the bottom surface of the crown, the liner being formed by molding a deformable, resilient material; and
printed indicia on a bottom surface of the liner, the printed indicia formed by applying an ink to the bottom surface of the liner, the crown and the liner being configured to seal a beverage container containing a beverage such that the bottom surface of the liner and the printed indicia are exposed to the beverage.