US Pat. No. 10,888,662

APPARATUS FOR RECORDING INFORMATION CONCERNING THE USE OF AN INJECTION DEVICE

Sanofi-Aventis Deutschlan...

1. An apparatus for recording information concerning use of an injection device, the apparatus comprising:a mating unit configured to releasably attach the apparatus to the injection device;
an optical sensor configured to capture an image of information displayed by the injection device indicating a dialed dose of medicament, wherein the apparatus is configured to be attached to the injection device such that the optical sensor is substantially aligned with the information displayed by the injection device;
a processor configured to:
receive the captured image from the optical sensor;
recognize one or more characters from the captured image to determine dose information; and
convert the determined dose information into an image file; and
a memory configured to store the image file of the determined dose information, such that the dose information can be retrieved from the memory and displayed as an image.

US Pat. No. 10,888,661

MEDICAL DELIVERY DEVICE

HOFFMANN-LA ROCHE INC, L...

1. A medical delivery device, comprising:a rod element having a stem with a longitudinal axis, a distal end and a proximal end;
a dosage member comprising a delivery orifice and a chamber body with a distal end, a proximal end and a hollow interior, wherein the stem of the rod element extends into the interior of the chamber body of the dosage member and the delivery orifice is arranged adjacent to the proximal end of the stem of the rod element; and
a lock mechanism for changing the medical delivery device from a lock status to a dosing status, wherein
in the dosing status of the medical delivery device, the lock mechanism is disengaged whereby the rod element is movable along its longitudinal axis relative to the delivery orifice of the dosage member, such that a dosage chamber is formed in the interior of the chamber body of the dosage member between the stem of the rod element and the delivery orifice which dosage chamber increases when the rod element moves away from the delivery orifice, and
in the lock status of the medical delivery device, the lock mechanism is engaged to thereby prevent movement of the rod element along its longitudinal axis relative to the delivery orifice of the dosage member.

US Pat. No. 10,888,660

MEDICAL DELIVERY DEVICE

HOFFMANN-LA ROCHE INC., ...

1. A medical delivery device, comprising:a rod element having a stem with a longitudinal axis, a first thread arrangement, a distal end and a proximal end; and
a dosage member comprising a delivery orifice and a chamber body with a distal end, a proximal end and a hollow interior, wherein the stem of the rod element extends into the interior of the chamber body of the dosage member and the delivery orifice is arranged adjacent to the proximal end of the stem of the rod element,
wherein, in a dosing status of the medical delivery device,
the rod element is movable along its longitudinal axis relative to the delivery orifice of the dosage member by the first thread arrangement of the rod element and a second thread arrangement travelling along each other, wherein a dosage chamber is formed in the interior of the chamber body of the dosage member between the stem of the rod element and the delivery orifice which dosage chamber increases when the rod element moves away from the delivery orifice, and
the dosage member comprises the second thread arrangement, wherein, in the dosing status of the medical delivery device, the first thread arrangement of the rod element engages the second thread arrangement of the dosage member.

US Pat. No. 10,888,659

MEDICAL DELIVERY DEVICE

HOFFMANN-LA ROCHE INC., ...

1. A medical delivery device comprising:a rod element having a stem with a longitudinal axis, a first thread arrangement, a distal end and a proximal end;
a dosage member comprising a delivery orifice, a second thread arrangement, and a chamber body with a distal end, a proximal end and a hollow interior, wherein the stem of the rod element extends into the hollow interior of the chamber body of the dosage member and the delivery orifice is arranged adjacent to the proximal end of the stem of the rod element; and
a switching mechanism for changing the medical delivery device from a dosing status to a delivery status, the switching mechanism including a disengaging structure,
wherein in the dosing status of the medical delivery device,
the rod element is movable along its longitudinal axis relative to the delivery orifice of the dosage member by the first thread arrangement of the stem of the rod element and the second thread arrangement of the dosage member engaging with and travelling along each other, wherein a dosage chamber is formed in the interior of the chamber body of the dosage member between the stem of the rod element and the delivery orifice which dosage chamber increases when the rod element moves away from the delivery orifice, and moving the rod element along its longitudinal axis by applying an axial force to the rod element is prevented by the engagement between the first thread arrangement of the stem of the rod element and the second thread arrangement of the dosage member, and
wherein in the delivery status of the medical delivery device,
the rod element is movable along its longitudinal axis relative to the delivery orifice by applying an axial force to the rod element, and moving the rod element along its longitudinal axis by travelling the first thread arrangement of the stem of the rod element and the second thread arrangement along each other is prevented by the disengaging structure of the switch element which disengages the first thread arrangement of the stem of the rod element from the second thread arrangement of the dosage member upon changing the medical delivery device from the dosing status to the delivery status.

US Pat. No. 10,888,658

DISPOSABLE INJECTOR WITH INCREASED TRIGGERING RELIABILITY

LTS LOHMANN THERAPIE-SYST...

1. A disposable injector (4) having a longitudinal center axis (7) and having a piston actuation ram (60) which is supported in an inner tubular a housing (10) and which is loaded by a resilient energy store (50) comprising a helical compression spring and which can be unlocked by a displaceable triggering device (80), characterized in thatthe piston actuation ram (60) including an elongated cylindrical guiding journal (62) configured in an operative position to axially extend through and carry the helical compression spring (50), a disk-like ram plate (73) configured to retain the helical compression spring (50) on the elongated cylindrical guiding journal (62) operatively attached to the disk-like ram plate (73), a rod-like piston sliding member (76) operatively configured to operatively engage a cylinder/piston unit (100),
a tensile locking rod (21) configured to support the piston actuation ram (60), the tensile locking rod (21) having a U-shape and consisting of a straight main member (27) and an integral clamping member (25) at one end of the straight main member (27) extending perpendicularly to the straight main member (27) and an integral wrap-around hook (26) at another end of the straight main member (27) having a predetermined curvature extending from the straight main member (27),
the inner tubular housing (10) having a cylindrical basic shape and including an exterior surface elongated flattened portion (14) of predetermined length having a first slot-like aperture (16) proximate one end of the exterior surface elongated flattened portion (14) and a second slot-like aperture (18) proximate another end of the exterior surface elongated flatted portion (14), the straight main member (27) in the operative position configured to be carried on the exterior surface elongated flattened portion (14), the clamping member (25) configured in the operative position to pass through the first slot-like aperture (16) for clamping an end of the helical compression spring (50), the wrap-around hook (26) configured in the operative position to pass through the second slot-like aperture (18) and configured to grasp the disk like ram plate (73) to lock the piston actuation ram (60) and to lock the helical compression spring (50) in a compressed state prior to triggering of the disposable injector (4) and configured upon triggering by the displaceable triggering device (80) to expand outwardly away from the longitudinal center axis (7) and away from the second slot-like aperture (18),
the displaceable triggering device (80) comprising a triggering sleeve covering housing (82) which can be displaced relative to the inner tubular housing (10),
a displaceable triggering ring (190) displaceably arranged on the inner tubular housing (10) and supported by the triggering sleeve covering housing (82), the displaceable trigger ring (190) having a cylindrical inner wall (193) having an oblique abutment face (195) terminating at a lower shoulder (197) of the displaceable triggering ring (190), the oblique abutment face (195) facing inwardly and configured to retain and compress the wrap around hook (26) of the tensile locking rod (21) in the operative position in the slot-like aperture (18) to lock the ram (60) prior to an actuation of the triggering sleeve covering housing (82), the triggering sleeve covering housing (82), upon actuation of the triggering sleeve covering housing (82), configured to displace the displaceable triggering ring (190) longitudinally relative to the inner housing (10) and to simultaneously cause the tensile locking rod (21) in cooperation with the oblique abutment face (195) to slide outwardly and to release the compressed wrap-around hook (26), the grasped disk-like plate (73) and the helical compression spring (50),
the inwardly facing oblique abutment face (195) of the triggering ring (190) defines, with a longitudinal direction (5) of the disposable injector (4), a predetermined angle, wherein the apex of the predetermined angle is in a triggering direction (6) of the disposable injector (4) and is located offset with respect to the triggering ring (190).

US Pat. No. 10,888,657

METHOD AND APPARATUS FOR TREATMENT OF INTRACRANIAL HEMORRHAGES

EKOS CORPORATION, Bothel...

15. An ultrasound catheter comprising:an elongate tubular body having a distal portion and a proximal portion, the elongate tubular body comprising walls defining a first drainage lumen within the elongate tubular body and a delivery lumen within the elongate tubular body;
wherein the elongate tubular body does not have sufficient hoop strength, kink resistance, rigidity, and structural support to be pushed through an opening in a skull and into brain tissue;
wherein the drainage lumen includes a plurality of drainage ports on the distal portion of the elongate tubular body configured to allow fluid to flow therethrough;
wherein the delivery lumen includes a plurality of delivery ports on the distal portion of the elongate tubular body configured to allow fluid to flow therethrough;
a plurality of ultrasound radiating elements positioned within, the walls of the elongate tubular body, wherein the ultrasound radiating elements are piezoelectric ceramic oscillators;
a surface configured to form an electrical connection on the proximal portion of the elongate tubular body and a proximal port located adjacent and distal to the electrical connection, wherein the proximal port opens on an outer surface of the elongate tubular body in the proximal portion, wherein the proximal port is perpendicular to a longitudinal axis of the elongate tubular body; and
a stylet configured to be received within the drainage lumen.

US Pat. No. 10,888,656

SYRINGE PUMP

MEDCAPTAIN MEDICAL TECHNO...

1. A syringe pump, being operable in a manual operation mode and an electric operation mode, comprising:a pump body configured to mount a syringe;
a control system;
a transmission mechanism; and
a propulsion mechanism;
wherein the transmission mechanism comprises a bracket, a propulsion driving motor, a screw rod, a sliding seat, a half nut, and a clutch driving assembly; wherein the bracket is fixed in the pump body, the screw rod is axially in parallel with the syringe, and the screw rod is rotatably connected to the bracket along an axial direction of the screw rod; wherein the propulsion driving motor is fixed on the bracket and is in driving connection with the screw rod to drive the screw rod to rotate; wherein the sliding seat is slidably disposed in the pump body along an axial direction of the syringe; wherein the half nut is slidably disposed on the sliding seat with a sliding direction perpendicular to the axial direction of the screw rod; wherein the clutch driving assembly is disposed on the sliding seat and is in driving connection with the half nut to drive the half nut to slide reciprocally, whereby the half nut is close to or away from the screw rod repeatedly;
wherein the propulsion mechanism comprises a connecting rod, a pushing block, a pressure sensing assembly, and a clutch switch; wherein the connecting rod is axially in parallel with the syringe, and the connecting rod is slidably connected to the pump body along an axial direction of the connecting rod; wherein the connecting rod has a first end fixedly connected to the pushing block and a second end fixedly connected to the sliding seat; wherein the pressure sensing assembly is disposed on the pushing block, to abut against a piston rod of the syringe to detect pressure of the piston rod, and the pressure sensing assembly is electrically connected to the control system; wherein the clutch switch is disposed on the pushing block and electrically connected to the clutch driving assembly to control operation of the clutch driving assembly; and
wherein the propulsion driving motor and the clutch driving assembly are both electrically connected to the control system to enable the manual operation mode or the electric operation mode under control of the control system;
wherein the clutch driving assembly comprises a clutch driving motor and a clutch screw rod, the clutch driving motor being in driving connection with the clutch screw rod to drive the clutch screw rod to rotate along an axial direction of the clutch screw rod, and the half nut is provided with a threaded hole, wherein the clutch screw rod is in threaded connection in the threaded hole.

US Pat. No. 10,888,655

SYSTEM AND METHOD OF PAIRING AN INFUSION PUMP WITH A REMOTE CONTROL DEVICE

Tandem Diabetes Care, Inc...

1. A method of pairing a user-wearable infusion pump with a remote control device, the user-wearable infusion pump including one or more indicator lights and no display screen, comprising:receiving input at the remote control device to initiate a pairing procedure for pairing the remote control device with the user-wearable infusion pump;
determining, with the remote control device, whether the user-wearable infusion pump is available for the pairing procedure;
initiating the pairing procedure with the remote control device after determining that the user-wearable infusion pump is available for the pairing procedure;
presenting step by step instructions for the pairing procedure on a display screen of the remote control device;
providing visual feedback as to a status of the pairing procedure at a plurality of steps of the pairing procedure with the one or more indicator lights of the user-wearable infusion pump; and
confirming successful pairing of the remote control device with the user-wearable infusion pump with both the display screen of the remote control device and the one or more indicator lights of the user-wearable infusion pump.

US Pat. No. 10,888,654

INFUSION PUMP ASSEMBLY

21. A disposable portion of a wearable infusion pump assembly comprising:a reservoir for receiving an infusible fluid;
a fluid delivery system including a fluid line configured to deliver the infusible fluid from the reservoir to an external infusion set, at least a portion of the fluid line defined by a flexible membrane, wherein the fluid delivery system includes a volume sensor chamber including an acoustically contiguous region, the volume sensor chamber configured to receive a quantity of the infusible fluid from the reservoir, the acoustically contiguous region having a volume adjacent to the flexible membrane that varies based upon the quantity of infusible fluid received from the reservoir, the flexible membrane configured to define the volume to be excited by an acoustic energy emitter; and
a first valve located in the fluid line downstream of the fluid delivery system and upstream the volume sensor chamber and the external infusion set, the first valve including a protrusion with a valve inlet opening through and surrounded by the protrusion and a valve outlet, the protrusion being located between the valve inlet and the valve outlet, the first valve configured to selectively isolate the volume sensor chamber from the external infusion set as the flexible membrane moves to interact with the protrusion of the valve to selectively close a portion of the fluid line between the volume sensor chamber and the external infusion set.

US Pat. No. 10,888,653

FEEDING SET WITH CASSETTE AND RELATED METHODS THEREFOR

KPR U.S., LLC, Mansfield...

1. A pump set for use with a pumping apparatus having a rotor with a plurality of rollers mounted on the rotor rotatable about an axis of rotation, the pump set comprising:a cassette body having a top, a bottom, sides, and a center defined by a point midway between the top and the bottom and midway between the sides, the cassette body comprising a flexible stator with a fixed end secured to the cassette body at a connection, a second end opposite the fixed end, a middle portion including a reaction surface and a second surface opposite the reaction surface, the middle portion defined between the fixed end and the second end, the second end being free from any structure of the cassette body aside from the middle portion, the flexible stator having an arcuate shape curving inwards relative to the center of the cassette body; and
a deformable tube secured to the cassette body, at least a portion of the deformable tube configured to be disposed against the reaction surface, the flexible stator being arranged in the cassette body to permit the flexible stator to float in the cassette body as the plurality of rollers traverse the deformable tube over a length of the reaction surface of the flexible stator, the flexible stator being constructed to pivot about the connection to the cassette body and flatten out upon engagement of the deformable tube by the plurality of rollers of the rotor during rotation of the rotor to deliver fluid through the deformable tube,
wherein a section of the flexible stator extends along an entire length of the flexible stator from the fixed end to the second end, a width of the section extending partially across the flexible stator, and a thickness of the section extending from the reaction surface to the second surface, the thickness being constant along the entire length of the section.

US Pat. No. 10,888,652

FOOT VALVE FOR DRIP CHAMBERS OF MEDICAL INFUSION OR TRANSFUSION APPARATUSES

INDUSTRIE BORLA S.P.A, T...

1. Foot valve for drip chambers of medical infusion or transfusion apparatuses, comprising:an annular valve seat with which a float obturator which is axially displaceable between a closed position and an open position of the valve seat cooperates,
a containment cage bush having an elastically deformable lateral wall within which said float obturator floats in a guided fashion,
the lateral wall of the containment cage bush and the float obturator having respective mutually facing surfaces configured such that a radial deformation of the containment cage bush applies an axial thrust to the float obturator in the direction of moving the float obturator apart from said annular valve seat, and
wherein the lateral wall of the containment cage bush is formed by a crown of elastically deformable axial sectors with free ends having diverging portions facing towards a corresponding diverging annular wall of the float obturator.

US Pat. No. 10,888,651

MAGNETIC PRESSURE JACKET FOR FLUID INJECTOR

BAYER HEALTHCARE LLC, Wh...

1. A fluid injector comprising:at least one injector head having a front end configured to releasably receive at least one syringe;
at least one pressure jacket releasably associated with the front end of the at least one injector head for securing the at least one syringe during an injection procedure; and
a connection mechanism for releasably connecting the at least one pressure jacket to the front end of the at least one injector head,
wherein the connection mechanism comprises at least one electromagnet,
wherein an electromagnetic force of the at least one electromagnet is controlled by a controller of the fluid injector.

US Pat. No. 10,888,650

TESTING OF A MEDICAL FLUID TREATMENT SYSTEM

Debiotech S.A., Lausanne...

1. A method for detecting a failure in a system for providing a medical treatment to a patient, the system including a fluid pathway in removable fluidic communication with the patient, a pump, an occlusion element for the fluid pathway, and a sensor for measuring a pressure in the fluid pathway, the pump and the sensor operatively connected to an electronic processor, the pump configured to move a fluid through the fluid pathway, the system configured to infuse or remove the fluid to or from the patient via the fluid pathway, the method comprising the steps of:blocking the fluidic communication between the patient and the fluid pathway after the medical treatment is completed;
performing a test to detect an operational failure of the system, the performing the test including,
actuating the pump,
measuring a pressure by the sensor in the fluid pathway,
monitoring the measured pressure by the electronic processor,
determining by the electronic processor whether the operational failure is present based on the monitored pressure,
stopping the pump when at least one of the monitored pressure reaches a predetermined threshold, a number of pump stroke reaches a predetermined value, and a duration of the test reaches a predetermined time value; and
determining the operational failure of the system when the pump is stopped before the measured pressure has reached the predetermined threshold.

US Pat. No. 10,888,649

FLUID LEAK DETECTION IN A DIALYSIS MACHINE

Fresenius Medical Care Ho...

1. A dialysis machine, comprising:a housing including an outer periphery surface and an elongated slot formed in the outer periphery surface;
a cartridge insertable into the elongated slot, the cartridge being operatively coupled to fluid flow lines so that fluid is moved through the cartridge when the cartridge is positioned in the elongated slot formed in the housing; and
a leak detector disposed in the elongated slot of the housing, the leak detector being arranged and configured to at least partially surround the cartridge when the cartridge is positioned in the elongated slot formed in the housing;
wherein in response to fluid contacting the leak detector, a leak in the dialysis machine is detectable.

US Pat. No. 10,888,648

DIALYSIS PRIMING STEPS USING AN INFUSATE CADDY

Medtronic, Inc, Minneapo...

1. A method for priming a dialysis machine, comprising the steps of:fluidly connecting two or more detachable infusate containers seated in a removable infusate caddy, the removable infusate caddy having one or more fitting features defining two or more receiving compartments in the infusate caddy; wherein every receiving compartment included in the infusate caddy has a size and/or shape different from every other receiving compartment included in the infusate caddy; each of the at least two receiving compartments in the infusate caddy complementary to one of the two or more detachable infusate containers; each of the two or more detachable infusate containers fitting into one specific receiving compartment defined by the one or more fitting features within the removable infusate caddy, wherein at least one fitting feature on each detachable infusate container is complementary and of a unique size to the one or more fitting features on the removeable infusate caddy; wherein the one or more fitting features of the infusate caddy are configured to define only one arrangement of the two or more detachable infusate containers within the infusate caddy;
selectively opening or closing one or more valves to form a priming flow path in the dialysis machine;
pumping water using one or more pumps into the priming flow path and through two or more detachable fluid connectors into the two or more detachable infusate containers containing one or more solutes;
dissolving the one or more solutes in the two or more detachable infusate containers to form a solution of the one or more solutes inside the two or more detachable infusate containers or adding water to the two or more detachable infusate containers to form the solution of the one or more solutes inside the two or more detachable infusate containers;
selectively opening or closing the one or more valves to form a dialysate flow path in the dialysis machine; and
pumping the solution from the two or more detachable infusate containers into the dialysate flow path to prime the dialysis machine with the one or more solutes.

US Pat. No. 10,888,647

DEVICE FOR EXTRACORPOREAL BLOOD TREATMENT COMPRISING AN IMPROVED ARRANGEMENT OF A BLOOD TREATMENT DEVICE

B. BRAUN AVITUM AG, Mels...

1. A device for extracorporeal blood treatment, the device comprising:a housing having an internal fluidic system for a treatment liquid, a first housing liquid connector, and a second housing liquid connector, the first and second housing liquid connectors configured to convey a treatment liquid through the internal fluidic system, the housing further comprising a front operating surface forming a user interface;
a cylindrical filter element that extends along a cylinder longitudinal axis from a first end to a second end and has a first treatment liquid connector at the first end and a second treatment liquid connector at the second end;
a mounting configured to hold the cylindrical filter element, wherein the mounting is oriented such that a cylinder longitudinal axis of the cylindrical filter element is substantially horizontally aligned when the cylindrical filter element is held by the mounting, and wherein the mounting is configured such that the cylindrical filter element is rotatable about the cylinder longitudinal axis while in the mounting between a first orientation in which the first treatment liquid connector and the second treatment liquid connector face upwards and a second orientation in which the first treatment liquid connector and the second treatment liquid connector face downwards;
the mounting being rotatably attached to the front operating surface of the housing, the mounting being rotatable relative to the front operating surface about a swivel axis, the swivel axis extending orthogonal to the front operating surface of the housing,
the swivel axis also extending orthogonal to the cylinder longitudinal axis and through a midsection of the cylindrical filter element when the cylindrical filter element is held by the mounting, the cylindrical filter element being rotatable in the mounting and about the swivel axis between a first angle of inclination in which the cylinder longitudinal axis is horizontal and a second angle of inclination in which the cylinder longitudinal axis is inclined relative to horizontal;
a first flexible line section connecting the first treatment liquid connector to the first housing liquid connector and having a first flexible line length selected to allow the first flexible line section to be connected between the first treatment liquid connector and the first housing liquid connector when the cylindrical filter element is in the first orientation and in the second orientation; and
a second flexible line section connecting the second treatment liquid connector to the second housing liquid connector, and having a second flexible line length selected to allow the second flexible line section to be connected between the second treatment liquid connector and the second housing liquid connector when the cylindrical filter element is in the first orientation and in the second orientation.

US Pat. No. 10,888,646

VENTRICULAR ASSIST DEVICE AND METHOD

NUHEART AS, Bergen (NO)

1. A method for positioning an intracorporeal device comprising the step of securing an intracorporeal device across at least two anatomical walls of the heart, wherein at least one of the least two anatomical walls is an intra-cardiac wall and a least one of the least two anatomical walls is an extra-cardiac wall, wherein the intracorporeal device comprises a proximal portion, an intermediate portion, and a distal portion, wherein the intermediate portion comprises one or more fluid inlet ports and wherein the proximal portion is positioned in a first anatomical compartment, wherein the intermediate portion is positioned in a second anatomical compartment, wherein the proximal portion comprise a motor, and wherein the intermediate portion comprises a pump.

US Pat. No. 10,888,645

PRESSURE/FLOW CHARACTERISTIC MODIFICATION OF A CENTRIFUGAL PUMP IN A VENTRICULAR ASSIST DEVICE

TC1 LLC, Pleasonton, CA ...

1. A ventricular assist device comprising:a centrifugal pump comprising a motor; and
at least one processor configured to:
determine an estimated flow rate through the centrifugal pump based on a current of the motor;
cause the motor to operate at a first speed when the estimated flow rate is greater than a predetermined flow rate during a user's systolic period; and
cause the motor to operate at a second speed when the estimated flow rate is less than the predetermined flow rate, wherein the predetermined flowrate corresponds to a particular flowrate through the centrifugal pump during a transition between systole and diastole phases of a person's cardiac cycle.

US Pat. No. 10,888,644

INTRA-CARDIAC LEFT ATRIAL AND DUAL SUPPORT SYSTEMS

inQB8 Medical Technologie...

1. A system for treating atrial dysfunction, the system comprising:a pressurizing element configured to be positioned in a left atrium of a heart of a patient; and
control circuitry configured to:
operate the pressurizing element to decrease a pressure in the left atrium and timed to coincide with atrial diastole to draw oxygenated blood out of the lungs of the patient by increasing a relative volume of the left atrium to reduce a filling pressure in the left atrium; and
operate the pressurizing element to increase the pressure in the left atrium and timed to coincide with atrial systole by reducing the relative volume of the left atrium to increase a left atrial pressure during atrial systole, wherein the increase in the left atrial pressure during atrial systole increases a pressure differential between the left atrium and a left ventricle that improves diastolic filling of the left ventricle.

US Pat. No. 10,888,643

NEGATIVE PRESSURE INTERBODY DEVICE, SYSTEM, AND METHOD

1. An implantable device for providing negative pressure therapy to an internal area of the body comprising:a body portion, wherein said body portion further comprises a posterior sidewall and an anterior sidewall;
an internal passageway; and
a plurality of openings in an outermost exterior surface of the anterior and posterior sidewalls, wherein said plurality of openings is in fluid communication with the internal passageway and a vacuum source.

US Pat. No. 10,888,642

METHOD AND SYSTEM FOR SIGNALING RESPONSIVE TO SENSING CONTAMINATION IN A SUCTION REGULATOR DEVICE

Amico Patient Care Corpor...

1. A suction regulator device comprising:a layer defining an entry point, a plurality of channels and a pathway that connects the entry point to the channels, the channels connectible to a vacuum terminal of a vacuum supply system;
at least one sensor located beside the pathway, wherein the sensor is configured to sense a change in clarity of a gas passing from the entry point to the vacuum terminal;
an alerting device that is configured to generate an alert; and
a processor configured to:
receive, from the sensor, a contamination indication based on the sensed change in clarity;
determine, from the indication, that the suction regulator device has been contaminated; and
transmit, to the alerting device, an instruction to generate an alert indicative of contamination.

US Pat. No. 10,888,641

LAYER BY LAYER COATED MESH FOR LOCAL RELEASE OF BIO-ACTIVE PROTEINS

1. A method for remodeling a target tissue, comprising:placing a biomaterial coated with a coating adjacent to the target tissue, wherein the coating includes
(a) at least one polycation layer;
(b) at least one polyanion layer; and
(c) at least one active agent-containing layer comprising dermatan sulfate and an M2 polarizing active agent,
wherein the M2 polarizing active agent is pre-incubated with the dermatan sulfate in a ratio between about 1:10 to about 1:2000 to be complexed, and
wherein the at least one polycation layer and the at least one polyanion layer alternate to form a bilayer.

US Pat. No. 10,888,640

DRUG COATED BALLOON CATHETERS FOR NONVASCULAR STRICTURES

Urotronic, Inc., Plymout...

1. A method for treating a stricture in a nonvascular body lumen, the method comprising:flushing a stricture site in the stricture in the nonvascular body lumen with a flushing media comprising water, saline solution, or a water solution comprising at least one water soluble additive, wherein the stricture is one of a colon stricture, a urethral stricture, a benign prostatic hyperplasia (BPH) stricture, a ureteral stricture, an esophageal stricture, a sinus stricture, and a biliary tract stricture;
inserting a balloon catheter to the stricture site in the stricture in the nonvascular body lumen, the nonvascular body lumen having a diameter, the balloon catheter comprising a balloon and a coating layer overlying external surfaces of the balloon;
holding the balloon catheter in position for a soaking period prior to inflation to soak the coating layer in the flushing media;
inflating the balloon until the coating layer contacts walls of the stricture in the nonvascular body lumen at the stricture site for an inflation period, wherein the ratio of the inflated balloon diameter to the nonvascular body lumen diameter is about 1.01 to about 30;
deflating the balloon after the inflation period, wherein the inflation period is from about 0.1 minutes to about 10 minutes; and
withdrawing the balloon catheter from the stricture in the nonvascular body lumen,
wherein
the coating layer comprises one or more additives and an initial drug load of a hydrophobic therapeutic agent,
the hydrophobic therapeutic agent is selected from the group consisting of paclitaxel, paclitaxel analogues, rapamycin, rapamycin analogues, and combinations thereof, and
the soaking period in combination with the contacting of the coating layer with the walls of the stricture is sufficient to release 37% to 97% of the initial drug load of the hydrophobic therapeutic agent from the coating layer.

US Pat. No. 10,888,639

DELIVERY CATHETERS FOR IN SITU FORMING FOAMS

Arsenal Medical, Inc., W...

1. A system for treating a patient, the system comprising:(1) a catheter having proximal and distal ends and having an outer catheter wall surrounding a first and second lumen along the entire length of the first and second lumen, said first lumen extending from the proximal end of the catheter to the distal end and the second lumen parallel to the first lumen and extending from the proximal end of the catheter and terminating in at least one exit port separated by a first distance from the distal end of the catheter and physically separated from the first lumen, the at least one exit port fluidly connecting the first lumen to the second lumen within the catheter; and
(2) first and second fluids configured to form a homogeneous polymeric formulation within the first lumen of the catheter, and to foam when mixed; andwherein the first lumen includes a mixing structure located distally relative to the at least one exit port, wherein said at least one exit port is located 0 to 10 cm from the distal end of the catheters and wherein the second lumen includes a plurality of exit ports oriented perpendicularly to the long axis of the catheter and wherein the distal end of the second lumen is sealed shut.

US Pat. No. 10,888,637

MECHANOCHEMICAL COLLAGEN ASSEMBLY

Northeastern University, ...

1. A method of assembling an organized array of fibrils, the method comprising:(a) providing a device comprising a microfluidic channel comprising an inlet and an outlet; wherein the inlet is configured to transport a collagen and/or elastin solution at a controlled flow rate; and wherein the outlet is configured to provide converging flow of the collagen and/or elastin solution;
(b) flowing a solution comprising prefibrillar collagen and/or elastin solution through the inlet into the microfluidic channel;
(c) creating a converging flow through the solution by hyperbolic contraction of the solution, wherein the hyperbolic contraction produces extensional strain and shear strain of collagen and/or elastin prefibrils of the solution; wherein collagen and/or elastin prefibrils of the solution assemble into said organized array of fibrils.

US Pat. No. 10,888,635

ABSORBENT ARTICLE HAVING ODOR ABSORBING MATERIAL

1. An absorbent article comprising:a chassis comprising a topsheet, a backsheet, an absorbent core disposed between the topsheet and the backsheet, and one or more adhesive materials forming an aggregate adhesive content;
wherein the absorbent core comprises an absorbent particulate polymer material and about 10% or less, by weight of the absorbent core, of cellulosic fibers;
wherein the backsheet comprises a monolayer film comprising a plurality of micropores, wherein the film comprises zeolites disposed in one or more of the micropores, wherein the zeolites disposed in the one or more of the micropores is at least partially incorporated into the film, and wherein the zeolites form an aggregate odor absorbing content; and
wherein a ratio of the aggregate odor absorbing content to the aggregate adhesive content is from about 0.5% to about 10%.

US Pat. No. 10,888,634

SYSTEMS AND METHODS FOR ATOMIZING LIQUIDS

Ideal Jacobs Corp., Mapl...

1. A system for dispersing vapor into ambient air, comprising:an atomizer comprising:
a housing having a first chamber extending from a bottom end to a top end, said top end having one or more apertures in fluid communication with the ambient air, said bottom end having a atomizing element;
a fan;
an air passage capable of allowing air to travel from the fan to the first chamber;
a pump;
a vessel port;
a tube leading from the pump to the vessel port;
a non-transitory memory having a machine-readable medium comprising machine executable code;
one or more processors coupled to the memory;
a scanner in electronic communication with the one or more processors; and
a telecommunications module in electronic communication with the one or more processors.

US Pat. No. 10,888,632

ULTRAVIOLET SANITATIONS SYSTEM AND METHOD

1. A method of sanitizing a towel, comprising:providing an ultraviolet sanitation system, the ultraviolet sanitation system comprising:
a body having a plate removably secured to an open upper end of the body;
a groove formed between the body and the plate, wherein the groove includes an open upper end extending around the open upper end of the body;
wherein the groove is adapted to access an interior volume of the body and slidably receive a towel assembly;
an ultraviolet light source adapted to emit ultraviolet light onto the towel assembly disposed within the body such that the ultraviolet light sanitizes the towel assembly;
wherein the ultraviolet light source is operably connected to a power source adapted to provide electrical energy thereto;
a sanitizing liquid disposed within the interior volume and adapted to saturate the towel assembly such that the sanitizing liquid light sanitizes the towel assembly;
loading the towel assembly into the body, such that a handle of the towel assembly remains exterior the groove and provides for gripping of the handle;
sliding the towel assembly from a first side of the groove to an opposing second side of the groove, such that the towel passes through the interior volume of the body;
emitting the ultraviolet light onto the towel assembly disposed within the body such that the ultraviolet light sanitizes the towel assembly;
removing the towel assembly from the ultraviolet sanitation system.

US Pat. No. 10,888,630

MAGNETIC NANOPARTICLES FUNCTIONALIZED WITH CATECHOL, PRODUCTION AND USE THEREOF

COLOROBBIA ITALIA S.P.A.,...

1. A human immune system cell containing a construct, said construct comprising:a structural center comprising a clustered plurality of magnetite nanoparticles, wherein the surface of each of the plurality of nanoparticles in the cluster is functionalized with catechol to provide hydrophobic reactivity to said clustered plurality of nanoparticles, and
a biocompatible polymeric matrix encapsulating the structural center, wherein a molecule having therapeutic action is optionally dispersed in said biocompatible polymeric matrix.

US Pat. No. 10,888,629

COMPOSITIONS OF NEAR IR CLOSED CHAIN, SULFO-CYANINE DYES AND PROSTATE SPECIFIC MEMBRANE ANTIGEN LIGANDS

Intuitive Surgical Operat...

1. A composition comprising a compound having the formula:wherein,R1, R2, R3, R4, R5, R6, and R7 are each independently hydrogen or C1-4 alkyl;
X is a single bond, —O—, or —S—;
subscripts a, b, c, d, e, f, g, and h are each independently an integer from 1 to 6, and
T is each independently a metal ion, H, or a negative charge;
Z is each independently H or C1-6 unsubstituted alkyl; andwherein, the composition is adapted for visualization of tissue under illumination with near-infrared radiation.

US Pat. No. 10,888,624

THERAPEUTIC DENDRIMERS

ASTRAZENECA AB, Sodertal...

1. A dendrimer of formula (III):D-Core-D  (III)or a pharmaceutically acceptable salt thereof, whereinCore is

AP is an attachment point to another building unit;
W is independently (PM)c or (H)e;
Z is independently (L-AA)d or (H)e;
PM is PEG1800-2400;
L-AA is a linker covalently attached to an active agent; wherein L-AA is of the formula:

wherein
A is —N(CH3);
(c+d) is an integer between 50 and 64;
provided that if (c+d)<64, then any remaining W and Z groups are (H)e, wherein e is 64?(c+d); and d is ?1.

US Pat. No. 10,888,623

HYDRAZINYL-INDOLE COMPOUNDS AND METHODS FOR PRODUCING A CONJUGATE

Redwood Bioscience, Inc.,...

1. A conjugate comprising:at least one modified amino acid residue of formula (I):

wherein
n is 0 or 1;
R1 is selected from hydrogen, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, cycloalkyl, substituted cycloalkyl, heterocyclyl, and substituted heterocyclyl;
R2 and R3 are each independently selected from hydrogen, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, alkoxy, substituted alkoxy, amino, substituted amino, carboxyl, carboxyl ester, acyl, acyloxy, acyl amino, amino acyl, alkylamide, substituted alkylamide, sulfonyl, thioalkoxy, substituted thioalkoxy, aryl, substituted aryl, heteroaryl, substituted heteroaryl, cycloalkyl, substituted cycloalkyl, heterocyclyl, and substituted heterocyclyl;
X1 is C or N, wherein if X1 is N, then Y1 is absent;
X2, X3 and X4 are each;
X5 is C;
Y1, Y2, Y3, Y4 and Y5 are each independently selected from hydrogen, halogen, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, alkoxy, substituted alkoxy, amino, substituted amino, carboxyl, carboxyl ester, acyl, acyloxy, acyl amino, amino acyl, alkylamide, substituted alkylamide, sulfonyl, thioalkoxy, substituted thioalkoxy, aryl, substituted aryl, heteroaryl, substituted heteroaryl, cycloalkyl, substituted cycloalkyl, heterocyclyl, and substituted heterocyclyl;
Q1 is a bond to X5 and Y5 is absent; and
L is an optional linker,
wherein W2 is an antibody comprising a converted sulfatase motif and W1 is a drug or a detectable label.

US Pat. No. 10,888,622

NANOCOMPLEXES OF MODIFIED PEPTIDES OR PROTEINS

Trustees of Tufts College...

1. A nanocomplex comprising a delivery agent and a pharmaceutical agent, wherein the nanocomplex has a particle size of 50 to 1000 nm, the delivery agent binds to the pharmaceutical agent via non-covalent interaction or covalent bonding, andthe pharmaceutical agent is a modified peptide or protein, comprising a peptide or protein and an added chemical moiety, wherein the added chemical moiety comprises a reactive oxygen species responsive group, wherein the reactive oxygen species responsive group comprises a boronic ester group; and
the added chemical moiety is:

wherein:
W is the boronic ester group;
X is O, S, or NRe, wherein Re, is H, OH, an amino acid radical, a peptide radical, a C1-C10 monovalent aliphatic radical, a C1-C10 monovalent heteroaliphatic radical, a monovalent aryl radical, or a monovalent heteroaryl radical;
Y is a bond, O, S, or NRf, wherein Rf is H, OH, an amino acid radical, a peptide radical, a C1-C10 monovalent aliphatic radical, a C1-C10 monovalent heteroaliphatic radical, a monovalent aryl radical, or a monovalent heteroaryl radical; and
Z is Rh-A7-A8-Ri, wherein Rh and Ri, independently, are a bond or a C1 aliphatic radical; A7 is a bivalent aryl radical or a bivalent heteroaryl radical; and A8 is a bond; and
the delivery agent is a surfactant, a lipid, a lipid-like compound, a polymer, a dendrimer, an inorganic nanoparticle, a polymer nanoparticle, an inorganic nanowire, a polymer nanowire, a nanotube, or a combination thereof; wherein
the lipid-like compound has the following formula:

wherein:
V is a hydrophilic head:
E is a C1-C24 monovalent aliphatic radical, a C1-C24 monovalent heteroaliphatic radical, a monovalent aryl radical, a monovalent heteroaryl radical, or T4-U2-T5-S—S-T6; T2-S—S-T3 is a hydrophobic tail; and
U1 and U2 are each a linker,wherein each of T1 and T4, independently, is a bond, a C1-C10 bivalent aliphatic radical, a C1-C10 bivalent heteroaliphatic radical, a bivalent aryl radical, or a bivalent heteroaryl radical; each of T2 and T5, independently, is a bond, a C1-C20 bivalent aliphatic radical, a C1-C20 bivalent heteroaliphatic radical, a bivalent aryl radical, or a bivalent heteroaryl radical; each of T3 and T6, independently, is a C1-C20 monovalent aliphatic radical, a C1-C20 monovalent heteroaliphatic radical, a monovalent aryl radical, or a monovalent heteroaryl radical; and S—S stands for a disulfide moiety.

US Pat. No. 10,888,602

COMPOSITIONS AND METHODS FOR INHIBITING THE BIOLOGICAL ACTIVITY OF SOLUBLE BIOMOLECULES

NaNotics, LLC, Mill Vall...

1. A particle having at least one surface, an agent immobilized on the surface, and a coating immobilized on the surface, wherein:the agent immobilized on the surface selectively binds to a target that is a first member of a specific binding pair;
binding of the target to the agent immobilized on the surface inhibits the interaction of the target with a second member of the specific binding pair;
the target is a soluble biomolecule, and
the coating inhibits interactions between the agent immobilized on the surface and molecules on a cell surface.

US Pat. No. 10,888,579

COMPOSITIONS FOR CONFERRING TOLERANCE TO VIRAL DISEASE IN SOCIAL INSECTS, AND THE USE THEREOF

BEEOLOGICS INC., St. Lou...

1. A method for increasing the tolerance of an adult bee to a disease caused by at least one bee pathogen, comprising feeding the adult bee an effective amount of a bee-ingestible composition comprising bee feed and a double stranded ribonucleic acid (dsRNA) comprising an RNA sequence capable of hybridizing to an mRNA transcript encoding a polypeptide or an RNA target sequence of the at least one bee pathogen, thereby increasing the tolerance of the adult bee to the disease, wherein the dsRNA is a naked dsRNA and the bee-ingestible composition does not comprise a transfection promoting agent.

US Pat. No. 10,888,578

EXON SKIPPING OLIGOMER CONJUGATES FOR MUSCULAR DYSTROPHY

Sarepta Therapeutics, Inc...

1. A method for treating Duchenne muscular dystrophy (DMD) in a primate subject in need thereof, wherein the primate subject has a mutation of the dystrophin gene that is amenable to exon 51 skipping, the method comprising administering to the primate subject an antisense oligomer conjugate of Formula (IV):(peptide is SEQ ID NO: 4), or a pharmaceutically acceptable salt thereof.

US Pat. No. 10,888,573

PHOSPHOLIPID PREPARATIONS FOR THE IMPROVEMENT OF BRAIN PLASTICITY

ENZYMOTEC LTD., Migdal H...

1. A preparation comprising a non-mammalian derived mixture of phosphatidylserine comprising a concentration of phosphatidylserine of at least 40% w/w, wherein the percentage of linoleic acid (C18:2) attached to PS in the preparation with respect to the total fatty acid content attached to the PS in the preparation is lower than 8%, the percentage of Docosahexaenoic acid (DHA) attached to PS in the preparation with respect to the total fatty acid content attached to the PS in the preparation is greater than 25%; and at least 1% (w/w) of the PS in the preparation have a carbon number of 34 carbons.

US Pat. No. 10,888,566

CHEMOSENSITIZATION OF RESISTANT PSEUDOMONAS AERUGINOSA BY SYNTHETICALLY RELATED COMPOUNDS

KING ABDULAZIZ UNIVERSITY...

1. A method of preventing or treating an infection caused by Pseudomonas aeruginosa (Pa) in a subject in need thereof, comprisingadministering to the subject a compound of Formula I and an antibiotic, wherein the compound of Formula I has the following structure:
and salts, hydrates and stereoisomers thereof,whereinAr1 and Ar2 may be the same or different and are a substituted or unsubstituted aryl or heteroaryl;
X is
i) N, O, S or C and R is substituted or unsubstituted, saturated or unsaturated, branched or unbranched C1-C10 alkyl; a 5-8 carbon unicyclic ring that is substituted or unsubstituted, saturated or unsaturated, cyclic alkyl or heterocyclic; or a 10-12 carbon polycyclic ring that is substituted or unsubstituted, saturated or unsaturated, cyclic alkyl or heterocyclic;orii) X and R are atoms of
a 5-8 carbon unicyclic ring that is substituted or unsubstituted, saturated or unsaturated, cyclic alkyl or heterocyclic; or
a 10-12 carbon polycyclic ring that is substituted or unsubstituted, saturated or unsaturated, and cyclic alkyl or heterocyclic;andn1 and n2 are the same or different and =1 or 2.

US Pat. No. 10,888,565

COMPOUNDS AND COMPOSITIONS FOR OSSIFICATION AND METHODS RELATED THERETO

Emory University, Atlant...

1. A method of treating osteoporosis comprising administering an effective amount of 1-(4-chlorophenyl)-5-isopropyl-biguanide or salt thereof to a subject in need thereof.

US Pat. No. 10,888,564

INHIBITORS OF HIV-1 INTEGRASE MULTIMERIZATION

Institute for Cancer Rese...

1. A method for inhibiting HIV-1 integrase multimerization in a cell comprising HIV-1 integrase, the method comprising contacting HIV-1 integrase with an amount of a compound of Formula II effective to inhibit the biologic activity of HIV-1 integrase:whereinR1, R2, R3, and R4 are independently selected from
a hydrogen atom,
an aliphatic group having a carbon number of from 1 to 18 in which one or more hydrogen atoms may be substituted by a halogen atom,
an aliphatic group having a carbon number of from 2 to 18 which comprises at least one moiety selected from the group consisting of —O—, —S—, —C(?O)—, —C(?O)—O—, —C(?O)—S—, —C(?O)—NH—, N-succinimidyl, and —O—C(?O)—NH—,
wherein at least one of the pairs R1 and R2 or R3 and R4 may be connected to form an alicyclic group, and wherein the aliphatic group optionally comprises at least one halogen atom.

US Pat. No. 10,888,563

FUSED HETEROTRICYCLIC ORGANIC COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, AND MEDICAL USES THEREOF

Alevere Medical Corporati...

1. A cosmetic method of modifying the contour of a subject's externally exposed body part containing fat, the method comprising administering to said body part an amount of a compound of Formula I-1, effective to modify the contour of said body part, whereinFormula I-1 is represented by:

or a pharmaceutically acceptable salt thereof, wherein:
R1 and R6 each represent independently for each occurrence hydrogen, halogen, —(C1-C6)alkyl, or —(C3-C6)cycloalkyl;
R2 is —N(R7)R8, —OR7, —(C1-C6)alkyl, or —(C3-C6)cycloalkyl;
R3 is hydrogen, —(C1-C6)alkyl, or —(C3-C6)cycloalkyl;
R4 is aralkyl or heteroaralkyl, each of which is optionally substituted with 1, 2, or 3 substituents independently selected from the group consisting of halogen, —(C1-C6)alkyl, —(C3-C6)cycloalkyl, hydroxyl, —(C1-C6)alkoxy, —N(R7)R8, —C(O)N(R7)R8, and —N(R7)C(O)R8;
R5 is hydrogen, —(C1-C6)alkyl, —(C3-C6)cycloalkyl, —CO2R7, —C(O)N(R7)R8, or —N(R7)C(O)R8;
R7 and R8 each represent independently for each occurrence hydrogen, —(C1-C6)alkyl, or —(C3-C6)cycloalkyl; or when R7 and R8 are attached to the same nitrogen atom, then R7 and R8 may be taken together with the nitrogen atom to which they are attached to form a 3-7 membered heterocycle; and
n is 1, 2, or 3.

US Pat. No. 10,888,562

AXL KINASE INHIBITORS AND USE OF THE SAME

Sumitomo Dainippon Pharma...

1. A crystalline form of a tartrate salt of the compound of structure (I):

US Pat. No. 10,888,561

CGRP RECEPTOR ANTAGONISTS

Heptares Therapeutics Lim...

1. A compound of formula (I)
or a salt thereof, wherein R1 is H or Q-(C1-C6)alkyl; where Q is a bond, C(O) or C(O)O and where the (C1-C6)alkyl can be optionally substituted by N(C1-C3alkyl)2 or CO2H;
R2 is H or forms a spirocyclic heterocyclic ring with R3;
R3 forms a spirocyclic heterocyclic ring with R2 or is a heterocyclic ring if R2 is H; and
R4 is an optionally substituted aryl group which is fused to a further ring.

US Pat. No. 10,888,560

PROCASPASE 3 ACTIVATION BY COMBINATION THERAPY

The Board of Trustees of ...

1. A method of treating cancer in a subject in need thereof comprising administering to a subject in need of therapy for cancer, concurrently or sequentially, a therapeutically effective amount of the compound PAC-1:and an effective amount of a second active agent, wherein the second active agent is tamoxifen, the concentration of tamoxifen is about 10 ?M to about 15 ?M and the cancer is breast cancer; the second active agent is bortezomib, the concentration of bortezomib is about 100 nM to about 5 ?M and the cancer is lymphoma; or the second active agent is staurosporine, the concentration of staurosporine is about 50 nM and the cancer is lymphoma; and the concentration of PAC-1 is about 15 ?M to about 30 ?M, wherein PAC-1 and the second active agent act synergistically upon administration, and the cancer is thereby treated.

US Pat. No. 10,888,559

QUINOLINE DERIVATIVES FOR NON-SMALL CELL LUNG CANCER

1. A method of treating a non-small cell lung cancer, the method comprising:orally administering to a human patient in need of treatment a daily dose of 8 mg to 16 mg of compound I having the following structural formula:

or a pharmaceutically acceptable salt thereof, wherein Compound I or the pharmaceutically acceptable salt thereof is administered at intervals wherein the ratio of the number of days in the dosing period to the withdrawal period is 2: 0.5 to 5.

US Pat. No. 10,888,558

REGIMENS OF TAFENOQUINE FOR PREVENTION OF MALARIA IN MALARIA-NAIVE SUBJECTS

60 Degrees Pharmaceutical...

1. A method of prevention of symptomatic P. falciparum malaria in a human subject, comprising:a) administering to the human subject two or more initial doses of a compound of Formula (I), a pharmaceutically acceptable salt thereof, or a pharmaceutical composition comprising a compound of Formula (I), wherein at least the first initial dose is administered prior to potential exposure of the subject to P. falciparum; and
b) administering to the human subject an exposure dose of said compound or composition one or more times per week during potential exposure of the subject to P. falciparum;
wherein about 75 to about 299 mg of said compound of Formula (I) is administered in each of said two or more initial doses,
wherein the total combined amount of said compound of Formula (I) administered in said initial doses is about 500 mg to about 900 mg,
wherein the total amount of said compound of Formula (I) administered through said exposure dose(s) is about 75 to about 299 mg per week,
wherein the human subject is malaria-nave and Glucose-6-phosphate dehydrogenase (G6PD) normal, and
wherein Formula (I) has the following structure,

US Pat. No. 10,888,554

SALTS OF HETEROCYCLIC MODULATORS OF HIF ACTIVITY FOR TREATMENT OF DISEASE

Board of Regents, The Uni...

1. A method for preventing or reducing tumor invasion and tumor metastasis in a patient with a tumor comprising the administration of a therapeutically effective amount of a compound of structural Formula III:
wherein:
M is selected from the group consisting of an inorganic acid, an organic acid, an amino acid;
with the proviso that M is not trifluoroacetic acid;
a is a fractional or whole number between about 0.5 and about 3.5 inclusive;
b is a fractional or whole number between about 0 and about 10 inclusive;
X2 and X4 are N and X5 is O; X4 and X5 are N and X2 is O; X2 and X5 are N and X4 is O; X2 is CH, X4 is N, and X5 is O; or X2 is CH, X4 is O, and X5 is N;
Z2 is selected from the group consisting of N and CR14;
R1 is selected from the group consisting of heterocycloalkyl, alkoxyalkoxy, alkylsulfonylalkoxy, heterocycloalkyloxy, heterocycloalkylcarbonyl, alkoxyalkylamido, heterocycloalkylsulfonyl, alkoxyalkylsulfonamido, wherein said heterocycloalkyl, heterocycloalkyloxy, heterocycloalkylcarbonyl, and heterocycloalkylsulfonyl can be optionally substituted with one or more substituents selected from the group consisting hydrogen, alkyl, and oxo;
R14, R39, and R40 are independently selected from the group consisting of hydrogen, deuterium, halogen, alkyl, haloalkyl, perhaloalkyl, cyano, hydroxy, alkoxy, haloalkoxy, perhaloalkoxy, alkylthio, amino, and saturated 3- to 7-membered cycloalkyl, any of which may be optionally substituted; and
R18 is selected from the group consisting of alkyl, haloalkyl, perhaloalkyl, alkoxy, haloalkoxy, perhaloalkoxy, alkylthio, haloalkylthio, and perhaloalkylthio.

US Pat. No. 10,888,553

USE OF NON-TRANSITION METAL COORDINATED DIPYRIDOXYL COMPOUNDS TO PREVENT AND TREAT CHEMOTHERAPY-INDUCED PSN

KARLSSON-TUNER INVEST AS,...

1. A method for the treatment of a chemotherapy drug induced peripheral sensory neuropathy in a patient undergoing chemotherapy, wherein the chemotherapy drug comprises platinum ions, the method comprising administering to the patient an effective amount of a platinum ion chelating dipyridoxyl compound according to Formula I, or a pharmaceutically acceptable salt thereof, wherein the dipyridoxyl compound is coordinated with a metal ion which is not a transition metal or uncoordinated,
wherein
X represents CH or N,
each R1 independently represents hydrogen or —CH2COR5;
R5 represents hydroxy, optionally hydroxylated alkoxy, amino or alkylamido;
each R2 independently represents ZYR6 wherein Z represents a bond or a C1-3 alkylene or oxoalkylene group, optionally substituted by R7;
Y represents a bond, an oxygen atom or NR6;
R6 is a hydrogen atom, COOR8, alkyl, alkenyl, cycloalkyl, aryl or aralkyl group, optionally substituted by one or more groups selected from COOR8, CONR82, NR82, OR8, ?NR8, ?O, OP(O) (OR8)R7 and OSO3M;
R7 is hydroxy, optionally hydroxylated, optionally alkoxylated alkyl or aminoalkyl group;
R8 is a hydrogen atom or an optionally hydroxylated, optionally alkoxylated alkyl group;
M is a hydrogen atom;
R3 represents a C1-8 alkylene, a 1,2-cykloalkylene, or a 1,2-arylene group, optionally substituted with R7; and each R4 independently represents hydrogen or C1-3 alkyl.

US Pat. No. 10,888,551

DRUG DELIVERY SYSTEM

INDIAN INSTITUTE OF TECHN...

1. A drug delivery system for anti-cancer compounds, said system comprisinga. a template nucleus selected from at least one of calcium carbonate, calcium phosphate and mesoporous silica for encapsulation of anti-cancer compounds,
b. at least one anti-cancer compound is a small molecule tyrosine kinase inhibitor, its salts, solvates, analogs, polymorphs, derivatives, isomers and enantiomers thereof,
c. at least two polyelectrolytes for polymeric layering of encapsulated anti-cancer compound, said polyelectrolytes are selected from at least one polyanionic and at least one polycationic electrolyte for forming at least two layers; one layer each of polyanionic electrolyte and polycationic electrolyte, respectively and not necessarily in that order;
wherein said polyanionic electrolytes for polymeric layering are selected from at least one of dextran sulfate, polyethylene glycol, cellulose and alginate;
wherein said polycationic electrolytes for polymeric layering are selected from at least one of poly-L-arginine, polyglycolic acid, poly-L-lysine, chitosan and protamine;
wherein said system is a layer-by-layer nano-particulate template nucleus encapsulated anti-cancer compound.

US Pat. No. 10,888,548

ANTI-DANDRUFF COMPOSITIONS COMPRISING A SPIROFURANONE LACTAM TETRAMIC ACID DERIVATIVE

Croda International Plc, ...

1. An anti-dandruff composition comprising an effective amount of:at least one compound selected from the group consisting of pseurotin A, pseurotin A1, pseurotin A2, pseurotin B, pseurotin C, pseurotin E, pseurotin D, pseurotin F1, pseurotin F2, asaspirenen, and synerazol; and
at least one meroterpene represented by formula (I):
wherein:R1 represents hydrogen and R2 represents chlorine, or R1 and R2 together represent a single bond to form an epoxide ring;
R3 represents hydrogen or hydroxyl;
R4 represents a hydroxyl, oxygen, or —OC(O)—[CH?CH—]nR5 group wherein R5 represents a C2-C4 alcohol or diol, a C2-C4 optionally substituted epoxide, or a carboxyl group; and
n represents an integer in the range from 1 to 3.

US Pat. No. 10,888,547

AMORPHOUS AND A CRYSTALLINE FORM OF GENZ 112638 HEMITARTRATE AS INHIBITOR OF GLUCOSYLCERAMIDE SYNTHASE

Genzyme Corporation, Cam...

1. A method of treating a human patient with Gaucher disease in need of treatment comprising:(i) assessing said patient with Gaucher disease, prior to initiation of treatment, through CYP2D6 genotyping, as being a poor, intermediate, or extensive CYP2D6 P450 metabolizer; and
(ii) administering a therapeutically effective amount of a compound of formula (I)
or a pharmaceutically acceptable salt thereof to the patient assessed as being a poor metabolizer, wherein the effective amount of the compound is 84 mg per day of the compound of formula (I), or an equivalent amount of a pharmaceutically acceptable salt thereof.

US Pat. No. 10,888,545

COMPOSITIONS AND METHODS FOR TREATING ESTROGEN-RELATED MEDICAL DISORDERS

THE BOARD OF TRUSTEES OF ...

1. A method for treatment of an estrogen-related medical disorder, the method comprising administering to a subject in need of such treatment a composition comprising a therapeutically effective amount of at least one compound of formula (I)
or a pharmaceutically acceptable salt thereof,
wherein
R1 is selected from the group consisting of hydrogen, alkyl, —SO3Rx1, —PO3Ry1Rz1, and —C(?O)Ra;
R2 is selected from the group consisting of halo and —OR3;
R3 is selected from the group consisting of hydrogen, alkyl, —SO3Rx1, —PO3Ry1Rz1, and —C(?O)Ra;
A1 is —ORb2 or —C(?O)Rb3;
Rb3 is selected from the group consisting of cycloalkyl, and phenyl substituted with 1, 2, or 3 halo;
Rb2 is selected from the group consisting of alkyl, cycloalkyl, and phenyl substituted with 1, 2, or 3 substituents independently selected from the group consisting of halo and —OR4;
R4 is selected from the group consisting of hydrogen, alkyl, —SO3Rx1, —PO3Ry1Rz1, and —C(?O)Ra;
R, at each occurrence, is independently selected from the group consisting of —OH and alkyl; and
Rx1, Ry1 and Rz1 are, at each occurrence, independently selected from the group consisting of hydrogen and a pharmaceutically acceptable cation;
provided that the compound of formula (I) contains at least one group selected from —OR3 and —OR4;
provided that 2-(4-fluorophenyl)-3-(4-hydroxyphenoxy)benzo[b]thiophen-6-ol is excluded from the compound of formula (I),
wherein the estrogen-related medical disorder is Alzheimer's Disease.

US Pat. No. 10,888,542

AMINOCARBONYLCARBAMATE COMPOUNDS

SK BIOPHARMACEUTICALS CO....

1. A method for treating dopamine reuptake-related diseases or promoting smoking cessation comprising:administering to a mammal in need thereof a therapeutically effective amount of a compound of Formula (I) or pharmaceutically acceptable salt thereof,

whereinX is independently halo, alkyl, alkoxy or nitro;m is 0, 1, 2, 3 or 4n is 1 or 2;R1 and R2 are independently H— or alkyl;R3 is H—, alkyl or aralkyl; andR4 is H— or aryl,wherein at least one of R1, R2, R3 and R4 is not H—,
wherein the dopamine reuptake-related disease is selected from the group consisting of fatigue, obesity, narcolepsy, fibromyalgia, cataplexy, drug addiction, sexual dysfunction, restless legs syndrome, bipolar disorder, depression, excessive daytime sleepiness, obsessive-compulsive disorder, and binge eating disorder.

US Pat. No. 10,888,534

STORAGE STABLE READY-TO-USE NOREPINEPHRINE AQUEOUS SOLUTIONS IN FLEXIBLE PLASTIC BAGS

InfoRLife SA, Campascio ...

1. A sterile, antioxidant-free aqueous norepinephrine solution packaged in a flexible plastic container in a sealed over-wrap pouch containing an oxygen absorber consisting essentially of between about 0.010 and 0.2 mg/ml of norepinephrine concentration as free base,a tonicity adjusting agent to provide an osmolality of from 260 and 320 mosm/kg, and
sufficient acid and optionally a base to provide a pH of from about 3.6 to 3.8, with the remainder water, andwherein dissolved oxygen in the solution has not been removed before filling the flexible plastic container with the solution, andwherein, after storage for from 12 months to about 24 months at room temperature of about 25° C., the solution remains clear and colorless and/or the solution contains 90% or more of an initial amount of norepinephrine.

US Pat. No. 10,888,531

DRUG DELIVERY SYSTEM FOR DELIVERY OF ACID SENSITIVITY DRUGS

DSM IP ASSETS B.V., Heer...

1. A fiber for the delivery of a bioactive agent to an eye of a mammal, the fiber comprising a cylindrical core and a shell partially surrounding the core, the core comprising a bioactive agent and a polyesteramide copolymer according to the following chemical formula:
wherein
m+p is from 0.9 to 0.1 and q is from 0.1 to 0.9;
m+p+q=1 whereby one of m or p could be 0;
n is about 5 to about 300;
a is at least 0.05, b is at least 0.05, a+b=1, qa=q*a, and qb=q*b; wherein units of
m if present, units of p if present, units of qa, and units of
qb are all randomly distributed throughout the copolymer;
R1 is (C2-C20) alkylene;
R3 and R4 are independently selected from hydrogen, (C1-C6)alkyl, (C2-C6)alkenyl, (C2-C6)alkynyl, (C6-C10)aryl, —CH2SH, —(CH2)2S(CH3), —CH2OH, —CH(OH)CH3, —(CH2)4NH3+, —(CH2)3NHC(NH2+)NH2, —CH2COOH, —CH2—CO—NH2, —CH2CH2—CO—NH2, —CH2CH2COOH, CH3—CH2—CH(CH3)—, (CH3)2CH—CH2—, H2N—(CH2)4—, Ph-CH2—, CH?C—CH2—, (CH3)2CH—, or Ph-NH—;
R5 is (C2-C20)alkylene;
R6 is structural formula (III);

R7 is (C6-C10)aryl(C1-C6)alkyl;
R8 is —(CH2)4—; and
the shell comprising a hydrolytically degradable polymer, the hydrolytically degradable polymer comprising poly(lactic acid), poly(glycolic acid), poly(lactide-co-glycolide), polycaprolactone, or a combination thereof.

US Pat. No. 10,888,521

SUSTAINED RELEASE COMPOSITIONS USING WAX-LIKE MATERIALS

Farnam Companies, Inc., ...

1. A composition comprising:(a) an active ingredient, wherein the active ingredient is glucosamine or a pharmaceutically acceptable salt thereof;
(b) from about 5% to about 40% of a wax-like agent, wherein the wax-like agent is hydrogenated vegetable oil; and
(c) from about 5% to about 40% of a spheronizing agent, wherein the ratio of the wax-like agent to the spheronizing agent is in a range from about 3:1 to about 1:14 by weight and; wherein the spheronizing agent is a member selected from the group consisting of microcrystalline cellulose and a combination of microcrystalline cellulose and pregelatinized starch, and wherein the spheronizing agent together with the active ingredient and the wax-like agent form a cohesive plastic mass that is malleable and is subsequently extruded and spheronized;
wherein (i) the composition is in the form of pellets, without a sustained release barrier coating, wherein said pellets have an average diameter of about 0.1 mm to about 3 mm in size and are either spherical or cylindrical in shape; (ii) the composition has an in vitro dissolution rate of the active ingredient measured by standard USP basket method of about 10% to about 60% of the active ingredient released after 1 hour;
about 20% to about 70% of the active ingredient released after 2 hours;
about 30% to about 80% of the active ingredient released after 4 hours;
about 40% to about 90% of the active ingredient released after 8 hours;
about 50% to about 100% of the active ingredient released after 12 hours; and (iii) the in vitro dissolution rate of the active ingredient does not require the presence of a sustained release barrier coating on the pellets.

US Pat. No. 10,888,519

IMMEDIATE RELEASE PHARMACEUTICAL COMPOSITION OF IRON CHELATING AGENTS

Jubilant Generics Limited...

1. A stable immediate release solid oral pharmaceutical composition consisting of:(a) from about 60 to 80% by weight Deferasirox or its pharmaceutically acceptable salts;
(b) from about 10.0 to 40.0% by weight of one or more diluents;
(c) from about 0.1% to 6.0% by weight of one or more binders;
(d) from about 0.1% to 10.0% by weight of one or more disintegrants; and
(e) from about 0% to 0.5% by weight of one or more surfactant; wherein the composition is free of glidant and is not in the form of a dispersible tablet.

US Pat. No. 10,888,510

PROCESS FOR DYEING KERATIN FIBRES USING AT LEAST ONE PARTICULAR 2- OR 4-AZOPYRIDINIUM DYE AND AT LEAST ONE FLUORESCENT DYE

1. A process for dyeing keratin fibres, comprising the application to said keratin fibres of the following ingredients:(a) one or more 2- or 4-azopyridinium dyes chosen from the compounds of formula (I) or (II) below, the optical isomers thereof, the geometrical isomers thereof, the tautomers thereof, the organic or mineral, acid or base salts thereof, the solvates thereof, and mixtures thereof,

in which formulae (I) and (II):
R1 and R?1, which may be identical or different, represent an optionally substituted linear or branched C1 to C6 alkyl radical;
R2 and R?2, which may be identical or different, represent:
a halogen atom, or
a linear or branched C1 to C4 alkyl radical;
R3 and R?3, which may be identical or different, represent, independently of each other:
a C1 to C4 alkyl radical,
a (di)(C1-C4)(alkyl)amino radical,
a (C1-C4)alkylcarbonylamino radical,
a hydroxyl radical,
a halogen atom,
a C1 to C4 alkoxy radical,
a (C1-C4)alkylthio radical,
or alternatively, two adjacent radicals R3 or R?3 together form a 6-membered aromatic ring optionally substituted with one or more hydroxyl or amino groups;
R4 and R?4, which may be identical or different, represent:
a (di)(C1-C4)(alkyl)amino radical,
a hydroxyl radical,
a C1 to C4 alkoxy radical,
a radical —NR5R6, in which R5 and R6, which may be identical or different, represent, independently of each other:
a linear or branched, optionally substituted C1 to C20 alkyl radical, or
a phenyl radical,
or alternatively, two radicals R3 of formula (I) or R?3 of formula (II) located, respectively, ortho to the group R4 (formula (I)) or R?4 (formula (II)) form, respectively, with R5 and R6 of the group R4 (formula (I)) or of the group R?4 (formula (II)) a 6- to 10-membered heterocycle optionally comprising one or more heteroatoms;
m, m?, n and n? are integers ranging from 0 to 4;
Y represents an anionic counterion or a mixture of organic or inorganic anions which ensure the electrical neutrality of the compounds of formula (I) and/or (II); and
(b) one or more fluorescent dyes;
it being understood that the 2- or 4-azopyridinium dye(s) (a) and the fluorescent dye(s) (b) are applied to said keratin fibres together or sequentially.

US Pat. No. 10,888,509

TOPICAL SKIN COMPOSITIONS FOR TREATING WRINKLES

Mary Kay Inc., Addison, ...

1. A method of increasing skin firmness or skin elasticity in a person's skin in need thereof, the method comprising topically applying to the skin a composition comprising an effective amount of Commiphora mukul resin or an extract thereof that includes oleo gum resin, wherein topical application of the composition to the skin in need thereof increases the skin firmness or elasticity.

US Pat. No. 10,888,507

COSMETIC OR DERMATOLOGICAL COMPOSITION COMPRISING A MEROCYANINE AND AN OILY PHASE COMPRISING AT LEAST ONE N-SUBSTITUTED AMIDE


and those corresponding to formula (3) below and also the E/E- or E/Z-geometrical isomer forms thereof:

in which
A is —O— or —NH;
R is a C1-C22 alkyl group, a C2-C22 alkenyl group, a C2-C22 alkynyl group, a C3-C22 cycloalkyl group or a C3-C22 cycloalkenyl group, said groups possibly being interrupted with one or more O; and
b) at least one oily phase comprising at least one amide selected from the group of amides of formula (4)

in which:
the R1 radical represents a linear or branched C1-C4 alkyl radical; a linear or branched C2-C4 alkenyl radical, or an aryl radical”, limits included;
the R2, R3 and R4 radicals, which may be identical or different, represent saturated or unsaturated, aliphatic, cycloaliphatic or cyclic, optionally functionalized, monovalent hydrocarbon-based radicals containing from 1 to 30 carbon atoms, limits included;
k is 0 or 1;
i is an integer from 0 to 2;
j is 0 or 1;
with the proviso that:
when j=1 then k is 0 and
R1 represents a linear or branched C1-C4 alkyl radical; a linear or branched C2-C4 alkenyl radical, or an aryl radical;
R2 represent a hydrogen atom or a linear or branched C1-C6 alkyl group;
R3 represents a hydrogen atom or a linear or branched C1-C6 alkyl group;
R4 represents a linear or branched C1-C10 alkyl radical, a linear or branched C2-C10 alkenyl radical or a sterol residue;
or with the proviso that:
when j=0, then i=0 and k=1 and R1 represents an unsaturated cyclic hydrocarbon-based radical, which is optionally substituted.

US Pat. No. 10,888,505

DOSAGE OF FOAM FOR DELIVERING CONSUMER DESIRED DOSAGE VOLUME, SURFACTANT AMOUNT, AND SCALP HEALTH AGENT AMOUNT IN AN OPTIMAL FORMULATION SPACE

The Procter and Gamble Co...

1. A dosage of foam comprising:a. from about 7.5 cm3 to about 70 cm3 of the foam;
wherein the foam comprises:
i. greater than 20% of a surfactant system by weight of the foam wherein the detersive surfactant system comprises from about 10% to about 30% anionic surfactant selected from the group consisting of sodium laureth sulfosuccinate, sodium laureth sulfate, sodium undecyl sulfate, sodium lauryl sulfate, and sodium cocoyl isethionate and from about 4% to about 12% zwitterionic surfactant selected from the group consisting of lauramidopropyl betaine, cocoamidopropyl betaine, and mixtures thereof;
ii. from about 45 wt. % to about 78 wt. % water;
iii. a foam density of from about 0.05 g/cm3 to about 0.35 g/cm3;
iv. a bubble size distribution comprising an R32 of from about 5 ?m to about 100 ?m;
v. from about 0.001 g to about 2.45 g of an anti-dandruff particulate selected from the group consisting of zinc pyrithione, zinc carbonate, and combinations thereof;
vi. a ? value of from about 0.0075 g/cm3 to about 0.1575 g/cm3; and
vii. a ?? value of from about 0.00005 g/cm3 to about 0.035 g/cm3 wherein the foam is dispensed from an aerosol dispenser utilizing a propellant.

US Pat. No. 10,888,503

PACIFIER WITH ONBOARD DROP SENSOR AND NOTIFICATIONS

1. An infant pacifier comprised of the following main parts:(a) a rigid case;
(b) a microcontroller;
(c) a shock sensor;
(d) a speaker;
(e) an audible alarm;
(f) a LED;
(g) a battery;
(h) a flexible nipple; and
wherein said microcontroller and said shock sensor are configured to detect a bounce when said infant pacifier is dropped such that detecting the bounce generates an audible alert and a visual alert.

US Pat. No. 10,888,502

MEDICATION ADHERENCE APPARATUS AND METHODS OF USE

Sensal Health, LLC, Chap...

1. A medication adherence apparatus comprising: a container element operably coupled to a cap device; the cap device obtains a weight of the container element, an orientation of the cap device, a temperature of the cap device, and a time stamp including a day, time, and date; wherein the weight of the container element is obtained when the container element is inserted into the cap device; a connection of the container element in the cap device is detected by the cap device; the orientation of the cap device is detected to determine if the cap device and the container element is upright generally along a vertical axis; any movements along the vertical axis, a longitudinal axis, or a lateral axis are detected; and the cap device receives a medication schedule and notification parameters to notify a patient by an alarm if medication is missed; wherein the alarm is selected from a group consisting of: an audio sound, a visual notification, an electronic notification, or a cell phone notification; wherein the container element is selected from a group consisting of: an ointment tube, wide-mouthed plastic jar, or a platform developed for storage, display, and utilization of medicament container selected from a group consisting of: a tube, pill bottle, balm jar, and tray; wherein the container element houses a medication selected from the group consisting of: pill, powder, liquid, or gas form; a hardware system combining sensors to record an orientation, temperature, time stamp, and location of the cap device and the hardware system operably coupled to a mobile device or a computing device; wherein the hardware sends an information signal to a mobile application or a server; wherein the cap device comprises a PCB, a first main housing, a first battery cover, a first spacer cap, a battery, a load cell, a bottom stop cap, alight pipe, and a base cap, a Surface Mount Transducer; and a plurality of screws; the load cell detects a movement and connection of the cap device to the container element; and a detection signal is sent to a remote module to notify a user if the cap device is secured to the container element and notifies a program or module every time the cap device is removed or secured to the container element; wherein the battery is operably disposed in the first battery cover is operably disposed over the PCB; the first battery cover is operably coupled with the first spacer cap; the first spacer cap is operably coupled with the light pipe and is operably disposed over the PCB; a first screw and a second screw secures the first main housing to the first spacer cap; the PCB is operably coupled with the Surface Mount Transducer and the PCB is operably disposed with the load cell; and the load cell is operably disposed on the base cap.

US Pat. No. 10,888,501

MEDICINE SUPPLY APPARATUS

TAKAZONO TECHNOLOGY INCOR...

1. A medicine supply apparatus comprising:a housing;
a drum disposed inside the housing, the drum being cylindrically shaped, a center line of the drum extending in an up-down direction; and
a cover for covering side surfaces on four sides of the housing, the cover on a front side of the housing being configured to be openable and closable,
the drum having four arc-shaped divided bodies, the four arc-shaped divided bodies being obtained by equally dividing the drum in a circumferential direction, and the drum being rotatable about the center line,
the four arc-shaped divided bodies each having an inner circumferential surface having a partially cylindrical surface shape, the four arc-shaped divided bodies each having a plurality of medicine containing units each containing a medicine, the plurality of medicine containing units being arranged side by side in an axial direction and in a circumferential direction of the inner circumferential surface, and
a plurality of axial passages each being formed to extend in the axial direction inward in a radial direction of the inner circumferential surface, such that the medicine discharged from each of the plurality of medicine containing units passes through one of the plurality of axial passages,
wherein each of the four arc-shaped divided bodies is pivotable about a rotation axis that is spaced apart from the center line and that extends in parallel with the center line, and
wherein one of the plurality of axial passages is exposed in a state where one of the four arc-shaped divided bodies is pivoted about the rotation axis in a direction away from the center line.

US Pat. No. 10,888,499

THIN FILM WITH NON-SELF-AGGREGATING UNIFORM HETEROGENEITY AND DRUG DELIVERY SYSTEMS MADE THEREFROM

Aquestive Therapeutics, I...

1. A process for manufacturing a resulting pharmaceutical film suitable for commercialization and regulatory approval said resulting pharmaceutical film having a substantially uniform distribution of a desired amount of a pharmaceutical active in individual doses of the resulting pharmaceutical film, comprising the steps of:(a) forming a Non-Newtonian visco-elastic polymer matrix by mixing, said matrix comprising a polymer selected from the group consisting of water-soluble polymers, water-swellable polymers and combinations thereof, a solvent selected from the group consisting of water, a polar organic solvent and combinations thereof, a pharmaceutical active, which polymer matrix is a shear-thinning pseudoplastic fluid when exposed to shear rates of 10-105 sec?1, said polymer matrix having a substantially uniform distribution of said pharmaceutical active;
(b) casting said polymer matrix;
(c) conveying said polymer matrix through a drying apparatus and rapidly drying said polymer matrix, to remove at least a portion of said solvent from said matrix to form a visco-elastic film having said pharmaceutical active substantially uniformly distributed throughout by rapidly increasing the viscosity of said polymer matrix upon initiation of drying within about the first 4 minutes to maintain said uniform distribution of said pharmaceutical active by locking-in or substantially preventing migration of said pharmaceutical active, wherein the temperature of the polymer matrix is 100° C. or less, wherein said drying apparatus uses air currents, which have forces below a yield value of the polymer matrix during drying, wherein content uniformity of said pharmaceutical active in substantially equal sized individual dosage units of said visco-elastic film is such that the amount of the pharmaceutical active varies by no more than 10% from the desired amount; and
(d) forming the resulting pharmaceutical film from said visco-elastic film by further controlling drying through a process comprising drying at a temperature differential ranging from 5° C. to 30° C. between polymer matrix inside temperature and outside exposure temperature to minimize degradation wherein water content of said resulting film is 10% or less, wherein said resulting pharmaceutical film having said substantially uniform distribution of pharmaceutical active by said locking-in or substantially preventing migration of said pharmaceutical active is maintained, such that content uniformity of said pharmaceutical active in substantially equal sized individual dosage units of said resulting pharmaceutical film is such that the amount of the pharmaceutical active varies by no more than 10% from the desired amount.

US Pat. No. 10,888,498

ADAPTER

1. An adapter for transferring a substance from a first container into a second container, the adapter comprising:an interior circumferential wall, configured to accept a first container, along which extends a cannula body, at least partially encompassed by said interior circumferential wall;
a hollow-cylindrical section, which is connected to the cannula body, and is connectable to the second container;
wherein a longitudinal axis of the cannula body extends perpendicularly to one side of an end wall that extends transversely to the interior circumferential wall and the hollow-cylindrical section, and wherein the longitudinal axis extends perpendicularly to an opposing side of the end wall; and
a cup-shaped outer body, comprising an exterior circumferential wall and the end wall, which extends transversely to the longitudinal axis of the outer body,
wherein the cup-shaped outer body comprises an insert, having the interior circumferential wall that can accept the container, and a bottom wall, wherein the cannula body originates from the bottom wall of the insert, and the hollow-cylindrical section originates from the end wall of the cup-shaped outer body; and
wherein the outer body and the insert are a unit, and are immovable with respect to each other along a longitudinal axis of the adapter.

US Pat. No. 10,888,497

DRUG RECONSTITUTION SYSTEM

Becton, Dickinson and Com...

1. A system comprising:a cartridge having a cartridge distal end, a cartridge proximal end, and a sidewall extending therebetween defining a cartridge chamber;
a first substance contained within the cartridge chamber;
a vial defining a vial chamber;
a second substance contained within the vial chamber; and
an adapter adapted for sequential engagement with the vial and the cartridge, the adapter comprising an adapter body defining a passage and a slider adapted to slide through at least a portion of the passage; and
a dual-tipped needle configured to be pushed through the passage by the slider,
wherein the adapter is configured such that, once the cartridge and the vial are engaged to the adapter, rotation between the cartridge and the adapter allows the slider to move through the passage causing a tip of the dual-tipped needle to pierce a septum of the vial and, after the septum of the vial is pierced, causing an opposing tip of the dual-tipped needle to pierce a septum of the cartridge, thereby establishing fluid communication between the cartridge and the vial through the dual-tipped needle.

US Pat. No. 10,888,496

MEDICAMENT VIAL ASSEMBLY

CORVIDA MEDICAL, INC., C...

1. A vial adapter assembly for a closed fluid transfer system, the vial adapter assembly comprising:a vial adapter, including:
a base defining an inner annular rim and an outer annular rim and a cavity therebetween;
an annular stem extending from the base and defining an opening having a plurality of fingers extending around the opening thereof, wherein each finger defines a proximal recess and a distal recess formed therein;
a cover supported on the outer annular rim, wherein an expansion chamber is defined within the cover and the base;
an adapter support situated within the cavity of the base, the adapter support including:
a male stem extending in a first direction from the base, the male stem selectively connectable to and insertable into an open distal end of a syringe adapter, the male stem defining a lumen extending therethrough;
a seal extending across the lumen of the male stem; and
a spike extending in a second direction from the inner annular rim and into the opening of the annular stem, wherein the spike includes a first lumen being in fluid communication with the lumen of the male stem, and wherein the spike includes a second lumen being in fluid communication with the expansion chamber; and
a bladder extending between the base and the cover; and
a vial collar including:
an annular body configured and dimensioned for sliding receipt within the annular stem of the vial adapter;
at least one tab projecting from an outer surface of the annular body and being configured for selective receipt in distal recess and proximal recess of a respective finger of the vial adapter; and
at least one retainer projecting from an inner surface of the annular body.

US Pat. No. 10,888,495

SCRAPING PLATE

BOE TECHNOLOGY GROUP CO.,...

1. A scraping plate, comprising:a main body, one end of the main body being provided with a scraping blade, and an other end opposite to the scraping blade being provided with a grip portion;
a storage chamber for storing a liquid medicine and an electric heater for heating the liquid medicine, both the storage chamber and the electric heater being provided inside the main body;
at least one liquid medicine outlet, provided on a surface of the scraping blade, wherein each of the at least one liquid medicine outlet is communicated with the storage chamber through a connecting tube;
a valve, mounted on the connecting tube for controlling open and close of an internal channel of the connecting tube;
a controller, provided inside the main body, and is in signal communication with a pressure detector;
the pressure detector, provided inside the grip portion and configured for detecting a pressure of the grip portion and transmitting the detected pressure to the controller,
wherein the controller is configured for comparing the detected pressure with a preset pressure, when the detected pressure is equal to or larger than the preset pressure, the controller controls the valve to open, so that the internal channel of the connecting tube is communicated with the storage chamber.

US Pat. No. 10,888,494

MASSAGE HOLDER APPARATUS

1. A massage apparatus holder, comprising:a first holder side having a first substantially flat portion and an indentation shaped to receive a portion of a massage apparatus;
a second holder side having a second substantially flat portion;
wherein the holder is larger in size than the massage apparatus, the thickness of the holder is at least 7 mm and a portion of the holder is attached to a body;
a massage apparatus cover, wherein the massage apparatus cover surrounds the rounding sides of the massage apparatus and at least one of the top end and the bottom end is uncovered.

US Pat. No. 10,888,493

OUT OF PHASE CHEST COMPRESSION AND VENTILATION

ZOLL Medical Corporation,...

1. A system for providing emergency care to a patient, the system comprising:a backboard arranged to support the patient;
a chest compressor attached to the backboard and positioned to engage the patient at the chest, the chest compressor configured to provide multiple chest compression cycles to the patient;
a cuirass attached to the backboard and positioned to engage the patient at the abdomen, the cuirass configured to generate negative pressure to pull outward on the abdomen and to provide multiple abdominal compression cycles to the patient; and
a controller comprising one or more processors configured to:
control the chest compressor to perform the multiple chest compression cycles according to a programmed sequence,
control the cuirass to perform the multiple abdominal compression cycles according to the programmed sequence, and
control the cuirass to generate the negative pressure to pull outward on the abdomen during the multiple abdominal compression cycles, and control the chest compressor and the cuirass such that: the multiple chest compression cycles are configured to provide a compression of a sternum to a compressed sternal position and each compression of the sternum to the compressed sternal position begins when an ongoing abdominal compression cycle of the multiple abdominal compression cycles is about one-quarter complete.

US Pat. No. 10,888,490

SCALP MASSAGER

1. A scalp massager comprising:a hub, a plurality of arms, and a plurality of massage balls;
wherein the hub produces an oscillatory motion of the plurality of massage balls located at the ends of the plurality of arms;
wherein the scalp massager is adapted to be placed on a head of a user and the oscillatory motion of the plurality of massage balls helps relieve stress and improves circulation;
wherein the hub comprises a housing, an electric motor, a control dial, a vibrator, and one or more batteries;
wherein the hub lies at the center of the scalp massager with the plurality of arms extending radially from the side of the hub at the bottom of the housing;
wherein the hub is intended to be placed on the top, center of the head;
wherein the electric motor converts electrical energy provided by the one or more batteries into a rotary motion of a motor shaft when the electric motor is energized;
wherein the motor shaft is coupled to the vibrator;
wherein the electric motor is energized when the control dial is moved from an off position to an on position;
wherein the electric motor is de-energized when the control dial is moved from the on position to the off position;
wherein a proximal end of each of the plurality of arms is pivotally coupled to the vibrator;
wherein the vibrator translates rotary motion of the motor shaft into the oscillatory motion of the plurality of massage balls by moving the proximal end of the plurality of arms;
wherein the vibrator moves the proximal end of each of the plurality of arms by lifting the proximal end up, dropping the proximal end down; and
wherein the plurality of arms form a circular arrangement with respect to the housing.

US Pat. No. 10,888,489

WALKING AID AND WHEEL ASSEMBLY THEREFOR

1. A walking aid comprising:(a) a support leg having an operative upper end and an operative lower end; and
(b) a wheel assembly for operative detachable attachment to the lower end of the support leg whereby the wheel assembly is adapted to be pushed in a forward direction by a user resting on the support leg, the wheel assembly comprising a chassis supporting (i) a plurality of wheels, and (ii) a stop operatively associated with the plurality of wheels, the stop operatively adapted to engage a ground surface when a torque is applied to the support leg by a user such that ft by applying torque to the support leg the user will arrest movement of the walking aid in the forward direction, and
wherein the chassis includes two opposing, laterally spaced apart chassis members, the plurality of wheels oriented in-line between the chassis members with axles of the plurality of wheels being parallel spaced apart along the chassis.

US Pat. No. 10,888,488

ASSISTANCE APPARATUS AND ASSISTANCE METHOD

PANASONIC INTELLECTUAL PR...

18. An assistance apparatus comprising:an upper body belt configured to be worn on an upper body of a user;
a first knee belt configured to be worn above a left knee of the user;
a second knee belt configured to be worn above a right knee of the user;
wires including a first wire, a second wire, a third wire, a fourth wire, a fifth wire, sixth wire, a seventh wire, and eighth wire;
a control circuit;
a walk timing detecting unit; and
motors including a second motor, a fourth motor, a sixth motor, and an eighth motor, wherein
the first wire is coupled to a first portion of the upper body belt and to the first knee belt, the first portion being located on a front side of the user, the first wire having a longitudinal direction extending from the first knee belt toward upper right on user,
the second wire is coupled to the upper body belt and to the first knee belt, the second wire having a longitudinal direction extending from the first knee belt toward upper left on the user, the longitudinal direction of the second wire crossing the longitudinal direction of the first wire on the front side,
the fourth wire is coupled to a fourth portion of the upper body belt and to the first knee belt, the fourth portion being located on a back side of the user, the fourth wire having a longitudinal direction extending from the first knee belt toward the upper right,
the third wire is coupled to the upper body belt and to the first knee belt, the third wire having a longitudinal direction extending from the first knee belt toward the upper left, the longitudinal direction of the third wire crossing the longitudinal direction of the fourth wire on the back side,
the fifth wire is coupled to a fifth portion of the upper body belt and to the second knee belt, the fifth portion being located on the back side, the fifth wire having a longitudinal direction extending from second knee belt toward upper left on the user,
the sixth wire is coupled to the upper body belt and to the second knee belt, the sixth wire having a longitudinal direction extending from the second knee belt toward upper right on the user, the longitudinal direction of the sixth wire crossing the longitudinal direction of the fifth wire on the back side,
the eighth wire is coupled to an eighth portion of the upper body belt and to the second knee belt, the eighth portion being located on the front side of the user, the eighth wire having a longitudinal direction extending from the second knee belt toward the upper left,
the seventh wire is coupled to the upper body belt and to the second knee belt, the seventh wire having a longitudinal direction extending from the second knee belt toward the upper right, the longitudinal direction of the seventh wire crossing the longitudinal direction of the eighth wire on the front side,
when the user turns left,
(i) the control circuit causes the second motor to generate a second tension larger than or equal to a first value in the second wire in a period of 65% or more of a first gait cycle of a left leg of the user and a period of 100% or less of the first gait cycle, and in a period of 0% or more of a second gait cycle of the left leg and a period of 20% or less of the second gait cycle, the second gait cycle being immediately after the first gait cycle,
(ii) the control circuit causes the fourth motor to generate a fourth tension larger than or equal to the first value in the fourth wire in the period of 65% or more of the first gait cycle and the period of 100% or less of the first gait cycle, and in the period of 0% or more of the second gait cycle and the period of 20% or less of the second gait cycle,
(iii) the control circuit causes the sixth motor to generate a sixth tension larger than or equal to the first value in the sixth wire in a period of 65% or more of a third gait cycle of a right leg of the user and a period of 100% or less of the third gait cycle, and in a period of 0% or more of a fourth gait cycle of the right leg and a period of 20% or less of the fourth gait cycle, the fourth gait cycle being immediately after the third gait cycle, and
(iv) the control circuit causes the eighth motor to generate an eighth tension larger than or equal to the first value in the eighth wire in the period of 65% or more of the third gait cycle and the period of 100% or less of the third gait cycle, and in the period of 0% or more of the fourth gait cycle and the period of 20% or less of the fourth gait cycle,
the control circuit causes the second, the fourth, the sixth, and the eighth motors to generate the second, the fourth, the sixth, and the eighth tensions, using information obtained from force sensors or drive amounts of the second, the fourth, the sixth, and the eighth motors,
the walk timing detecting unit determines the period of 65% or more of the first gait cycle of the left leg of the user and the period of 100% or less of the first gait cycle, the period of 0% or more of the second gait cycle of the left leg and the period of 20% or less of the second gait cycle, the period of 65% or more of the third gait cycle of the right leg of the user and the period of 100% or less of the third gait cycle, and the period of 0% or more of a fourth gait cycle of the right leg and a period of 20% or less of the fourth gait cycle, on the basis of information obtained using a sensor, and
a heel of the left leg touches a ground at 0% of the first gait cycle, the heel of the left leg touches the ground at 0% of the second gait cycle, a heel of the right leg touches the ground at 0% of the third gait cycle, and the heel of the right leg touches the ground at 0% of the fourth gait cycle.

US Pat. No. 10,888,487

GRASP ASSIST SYSTEM

United States of America ...

1. A grasp assist system comprising:a glove having a glove palm and a plurality of glove fingers, wherein the glove is configured to be worn on a hand and fingers of a user;
a flexion sensor configured to output flexion signals indicative of a level of flexion of the hand and fingers of the user;
a plurality of finger saddles, each of which is positioned to at least partially surround a phalange of a respective one of the fingers of the user when the user wears the glove;
one or more tendon actuators;
a plurality of flexible tendons each connected to and driven by at least one of the one or more tendon actuators, wherein each of the flexible tendons is also connected to a respective one of the finger saddles;
a set of contact sensors connected to at least some of the glove fingers and configured to detect contact between the glove and an object during execution of a hand maneuver; and
a controller in communication with the one or more tendon actuators and the flexion sensor, wherein the controller is configured, in response to the flexion signals, to selectively apply tension to the plurality of flexible tendons via the one or more tendon actuators at a tension level sufficient for moving the fingers of the user and the glove fingers,
wherein the controller is in communication with the set of contact sensors and is configured to adjust the tension to the plurality of flexible tendons, via the one or more tendon actuators, in response to the contact, and
wherein the controller is configured to execute a first operating mode in which closure of the glove as a whole occurs in response to flexion of any one of the fingers of the user, and a second operating mode in which closure of a particular glove finger of the plurality of glove fingers occurs in response to detection of flexion of a finger of the user corresponding to the particular glove finger.

US Pat. No. 10,888,486

TOE TAPPING EXERCISE EQUIPMENT

Elensys Co., Ltd., Inche...

1. A foot and toe exercise machine comprising:a foot rest part having a right foot rest adapted to seat a user's right foot thereon and a left foot rest adapted to seat the user's left foot thereon; and
an operating part coupled to the foot rest part to allow toe portions of the foot rest part to tap each other, the operating part comprising: a driving motor for transferring rotating power; a right foot rest operator for receiving the rotating power from the driving motor to operate the right foot rest; and a left foot rest operator for receiving the rotating power from the driving motor to operate the left foot rest, the driving motor being disposed between the right foot rest operator and the left foot rest operator and having rotary shafts extended from both sides of the driving motor,
wherein the right foot rest operator comprises:
a first driven gear for transferring the rotating power;
a first link coupled to the first driven gear to transfer the rotating power and having a bar portion and a gear portion; and
a first foot rest driving gear adapted to engage with the gear portion of the first link to receive the rotating power;
wherein the left foot rest operator comprises:
a second driven gear for transferring the rotating power;
a second link coupled to the second driven gear to transfer the rotating power and having a bar portion and a gear portion; and
a second foot rest driving gear adapted to engage with the gear portion of the second link to receive the rotating power,
whereby through the rotating power of the driving motor, the right foot rest and the left foot rest rotate.

US Pat. No. 10,888,485

EXERCISE DEVICE

Maureen Fleming, New Yor...

1. An exercise device, comprising a plurality of elastic and tubular stretching portions; a plurality of elastic and tubular handle portions, an inelastic fixation portion configured to be secured above a user; and a modulator, wherein the plurality of stretching portions is connected to the fixation portion, wherein the plurality of handle portions are respectively connected to the plurality of stretching portions, wherein each stretching portion is connected to one of the handle portions at a connection point, the exercise device further comprising a covering at each connection point that covers the connection point and secures the plurality of tubular and elastic looped handles in place, maintaining the structural integrity of the elasticity of the plurality of looped handles and stretching portions, wherein the plurality of elastic and tubular handle portions are structured to fit one or more parts of the upper and lower limbs of a user at the same time, wherein when the modulator is in a relaxed configuration, the user can slide the modulator vertically along at least one of the plurality of stretching portions, and wherein when the modulator is in a tightened configuration, the modulator ties together the plurality of stretching portions, to adjust the resistance provided to the user when the user pulls against the plurality of stretching portions.

US Pat. No. 10,888,484

RECONFIGURABLE PELVIC SUPPORT FOR SURGICAL FRAME AND METHOD FOR USE THEREOF

WARSAW ORTHOPEDIC, INC, ...

1. A positioning frame for supporting a patient including an adjustable pelvic support, the positioning frame comprising:a first vertical support portion and a second vertical support portion,
a main beam having a first end, a second end, and a length extending between the first and second end, the first vertical support portion and the second vertical support portion supporting the main beam, the first support portion and the second vertical support portion spacing the main beam from the ground, the main beam defining an axis of rotation relative to the first vertical support portion and the second vertical support portion, the main beam being rotatable about the axis of rotation between at least a first rotational position and a second rotational position, the axis of rotation substantially corresponding to a cranial-caudal axis of the patient when the patient is supported on the positioning frame, the main beam including a first portion at the first end rotatably interconnected relative to the first vertical support portion, a second portion at the second end rotatably interconnected relative to the second vertical support portion, and an elongated portion extending between the first portion and the second portion of the main beam;
a chest support and a leg support being moveably attached to the elongated portion of the main beam, the chest support for supporting at least a portion of a chest of the patient, and the leg support for supporting at least a portion of at least one leg of the patient; and
an adjustable pelvic support for supporting at least a portion of a pelvic area of the patient, the pelvic support including a leg portion, a base portion, a first arm portion, a second arm portion, and a head portion,
the leg portion including a first leg end portion and a second leg end portion, the base portion including a first portion, a second portion, a first base end portion provided on the first portion of the base portion, and a second base end portion provided on the second portion of the base portion, the second portion being telescopically moveable relative to the first portion, the first arm portion including a first arm end portion and a second arm end portion, the second arm portion including a third arm end portion and a fourth arm end portion, and the head portion including a pad portion having a patient contact surface,
the first leg end portion of the leg portion being pivotally attached relative to the first portion of the main beam and the first vertical support portion,
the first base end portion of the base portion being attached relative to the second leg end portion of the leg portion,
the first arm end portion of the first arm portion being pivotally attached relative to the second base end portion of the base portion to form a first joint,
the third arm end portion of the second arm portion being pivotally attached to the second arm end portion of the first arm portion to form a second joint,
the head portion being attached to the fourth arm end portion of the second arm portion;
wherein the pelvic support can be moved into and out of position with respect to the patient via pivotal movement of the leg portion relative to the first portion of the main beam and the first vertical support portion, pivotal movement of the first arm portion relative to the base portion, and pivotal movement of the second arm portion relative to the first arm portion, the pelvic support being moveable at least between a first position where the pad portion of the head portion is removed from the pelvic area of the patient, and a second position wherein the patient contact surface of the pad portion of the head portion is contacted to the at least a portion of the pelvic area of the patient; and
wherein the chest support, the leg support, and the pelvic support can support the patient thereon during rotation of the main beam between the first position and the second position thereof, and the pelvic support can be moved out of position after rotation of the main beam to provide access to the pelvic area of the patient.

US Pat. No. 10,888,483

SYSTEMS, DEVICES, AND METHODS FOR POSITION MONITORING AND MOTION COMPENSATION

VIRGINIA COMMONWEALTH UNI...

1. A positioning table for use during a medical procedure, comprising:a plate for providing a support surface for a specific part of a patient's body;
a plurality of sliding blocks mounted in linear tracks separated into parallel pairs;
a plurality of linkages that connect the plate to the sliding blocks, wherein the linkages connect to the plate and the sliding blocks with joints having at least two degrees of rotational freedom; and
a powertrain connecting external motors with the sliding blocks such that rotational motion of a motor causes a sliding block mounted in the linear track to translate along the track, thereby changing a position of one or more of the linkages,
wherein the plate, sliding blocks, linear tracks, linkages, and joints are metal-less.

US Pat. No. 10,888,482

RELOCATION MODULES AND METHODS FOR SURGICAL FIELD

1. A module for housing unrelated electronic and electromechanical equipment in a position proximate an arm-board of a surgical table and adjacent an anesthesia screen during surgery, the module comprising:a housing having a lower section and a tower-like upper section, wherein the housing is configured to house unrelated waste heat-producing electronic and electromechanical surgical equipment during surgery,
wherein the tower-like upper section is located above the lower section, wherein a rear portion of the lower section is configured to fit into a space adjacent the arm-board of the surgical table,
wherein the tower-like upper section is configured to be positioned adjacent an anesthesia side of the anesthesia screen facing a surgical field and the tower-like upper section is configured to be taller than a height of the anesthesia screen;
a fluid dispensing system comprising one or more hangers configured to receive one or more hanging bags of IV fluids; and
a cowling that encloses at least a portion of the housing to substantially confine the waste heat generated by the unrelated waste heat-producing electronic and electromechanical surgical equipment.

US Pat. No. 10,888,481

ADJUSTABLE SUPPORT APPARATUS FOR A SURGERY TABLE

Mizuho Orthopedic Systems...

1. A system of an adjustable support apparatus for a surgery table, comprising:a crossbar mounted to a post, the crossbar capable of being oriented perpendicular to the post such that first and second ends of the crossbar being in a different plane than first and second ends of the post;
a tower extending in a vertical direction between first and second ends of the tower, the tower configured to removably fix with the crossbar at a first opening formed in one of the crossbar and tower such that the crossbar and the tower securely engage with each other, the crossbar configured to rotate along an axis perpendicular to a plane of the crossbar while fixed to the tower; and
a carriage coupled to the tower, the carriage configured to move in upward and downward directions with respect to the crossbar, the carriage is not configured to move in the upward and downward directions without rotation of a slide lock knob coupled to the carriage, the rotation of the slide lock knob configured to disengage one or more pawls from a gear rack upon inward rotation of the one or more pawls.

US Pat. No. 10,888,479

BIOSAFETY ENCLOSURE FOR OCCUPANTS OF VEHICLES

1. A biosafety enclosure for one or more occupants of a vehicle, the biosafety enclosure comprising:a protective cover member made of a durable material shaped to form a three-dimensional structure that is installed inside of the vehicle and isolates the one or more occupants of the biosafety enclosure from other occupants of the vehicle;
a plurality of connectors attached to the protective cover member and configured to affix to a ceiling, a floor, a wall, and/or a structure within the vehicle in order to secure the protective cover member inside the vehicle, wherein the protective cover member encompasses at least one seat of the vehicle and wherein a size of the biosafety enclosure can be modified by reclining the at least one seat of the vehicle;
one or more air circulation vents disposed within the protective cover member, wherein the one or more air circulation vents are connectable to an external air filtration device or an air filtration system of the vehicle; and
an ingress/egress member comprised in the protective cover member to allow entry/exit of occupants to/from the biosafety enclosure.

US Pat. No. 10,888,478

LIMB IRRIGATION PAN DEVICE

1. A kit of parts for assembling a limb irrigation pan device comprising:a base having first and second opposing sides formed with alternating indentations and protrusions extending along the first and second opposing sides, said base having first and second opposite ends each having at least one upstanding elongated rib:
a first side wall having alternating spaced indentations and protrusions formed along a bottom section of the first side wall to enable the first side wall to be mounted to the base by inserting the alternating spaced indentations and protrusions formed along the bottom section of first side wall into corresponding alternating indentations and protrusions along the first side of the base;
a second side wall having alternating spaced indentations and protrusions formed along a bottom section of the second side wall to enable the second side wall to be mounted to the base by inserting the alternating spaced indentations and protrusions formed along the bottom section of the second side wall into corresponding alternating indentations and protrusions along the second side of the base;
first and second end panels for mounting onto opposite ends of the base so as to form a frame with the first and second side walls, said first and second end panels each having at least one slot formed in a bottom surface to receive the at least one upstanding rib at the first and second opposite ends of the base; and
a sling having coupling components along two opposite sides, the coupling components being adapted to attach the sling to the first and second side walls whereby the sling is coupled to the frame.

US Pat. No. 10,888,477

BED WITH MECHANISM FOR ASSISTING AN OCCUPANT TO STAND UP HAVING A SENSOR WITH ENERGY GENERATION

Wissner-Bosserhoff GmbH, ...

1. A bed, comprising:a height-adjustable lying surface, upon which a mattress rests;
a head part, a foot part, and/or at least one side part, wherein at least one of the parts in at least one state of the bed projects beyond the mattress of the bed;
a motor for adjusting the height of the lying surface as a mechanism for assisting standing up; and
a control system for controlling the motor to adjust the height, wherein the control system comprises:
at least one sensor including at least one actuating element actuatable to generate a control signal, an interface to emit the control signal, and at least one element for producing energy independent of wired and battery-supported energy supply sources, wherein the energy necessary for generating and transmitting the control signal is generated from the actuation of the at least one actuating element of the sensor from the outside; and
at least one actuator including an interface to receive the control signal, and a switching element to switch at least one current path or an adjusting element to set at least one voltage, one current or another physical variable on the basis of the control signal.

US Pat. No. 10,888,476

STANDING CHAIR

1. A standing chair, comprising:a main frame support assembly includes a right frame support and a left frame support, wherein the right frame support and left frame support are parallelly connected and securely locked via a connecting means;
at least two collapsible support arms having a first end and a second end, wherein the first end of the two collapsible support arms are movably affixed to a respective right frame support or left frame support, and the second end of the two collapsible support arms are pivotally connected to a backrest support via one or more fasteners, wherein the two collapsible support arms are configured to be automatically collapsible and retractable in accordance with a sitting mode or standing mode of the standing chair;
at least one backrest removably positioned on both backrest supports of the right frame support and left frame support and securely locked via one or more fasteners wherein the backrest comprises a backrest frame;
at least one seat securely and removably assembled to the two collapsible support arms, wherein the seat is configured to move in accordance with the two collapsible support arms;
one drive member positioned between the right frame support and at least one collapsible support arm on the right side of the standing chair, and another drive member positioned between the left frame support and at least one collapsible support arm on the left side of the standing chair, thereby automatically and comfortably raising the at least one collapsible support arm on the right side and left side of the standing chair, and tilting the seat in accordance with the sitting mode or standing mode of the standing chair using the drive members;
an automatic backrest adjustment assembly, configured to automatically adjust the backrest while in the sitting mode of the standing chair, and
a foot rest assembly includes a pair of leg support bars carrying a foot rest, pivotally and adjustably affixed to both the right frame support and left frame support using one or more fasteners.

US Pat. No. 10,888,475

LIGHTWEIGHT PATIENT TRANSPORTER

1. An improved patient transporter, comprising:a lightweight collapsible frame having a front member and a rear member pivotally attached to the front member,
a plurality of wheels mounted on the frame,
at least one supporting member for supporting a patient at least partially, and
at least one guiding member for guiding the movement of the transporter,
wherein the front member includes a tubular portion and the guiding member is connected to the front member tubular portion,
wherein the front member, the rear member, and the supporting member are arranged in a K configuration when the frame is in an expanded configuration; and
wherein the rear member and the supporting member can be pivoted to move the frame into a collapsed configuration to facilitate storage.

US Pat. No. 10,888,474

WHEELCHAIR POWER APPARATUS FOR ELECTRONIC DRIVING CONVERSION

ROBO3 CO., LTD., Seoul (...

1. A wheelchair power apparatus for electronic driving conversion comprising:clamps mounted at both sides of a sheet frame of a manual wheelchair;
a horizontal supporter mounted between the clamps;
a combining hub mounted directly below the center of the horizontal supporter;
a vertical supporter of which one end is mounted to the combining hub;
an angle setting hub mounted at the other end of the vertical supporter and having radial saw parts formed at both sides thereof; and
a coupling hub mounted on the angle setting hub, the coupling hub including a ring portion formed at the front thereof, an inclined surface formed downward from the ring portion, a coupling portion formed directly below of the inclined surface, and radial saw parts formed at both sides of the rear of the ring portion,
wherein the coupling hub is mounted to the angle setting hub by the medium of an angle setting bar having the radial saw parts formed at upper and lower portions, and a coupling unit mounted on an electronic module is assembled to the coupling hub in a detachable manner, so that the manual wheelchair is converted into an electronic wheelchair.

US Pat. No. 10,888,473

ARRAY OF DISPOSABLE PANT-TYPE GENDER-SPECIFIC ABSORBENT ARTICLES

1. An array of disposable pant-type gender-specific absorbent articles adapted for female and male users, the array comprises:a first subarray of absorbent articles including a first size absorbent article adapted for female users and a second size absorbent article adapted for female users, wherein the second size is larger than the first size,
a second subarray of absorbent articles including a third size absorbent article adapted for male users and a fourth size absorbent article adapted for male users, wherein the fourth size is larger than the third size,
wherein each absorbent article of the array has a longitudinal direction (Y) and a transverse direction (X) and comprises:
a front panel having a front waist edge, a pair of front leg edges and a pair of front side edges,
a back panel having a back waist edge, a pair of back leg edges, and a pair of back side edges,
an absorbent insert located mainly in a crotch portion of each absorbent article and the absorbent insert being connected to the front panel and the back panel and the absorbent insert having an absorbent core with longitudinal core edges, a front core edge and a back core edge, and the insert comprising a topsheet and backsheet,
wherein each absorbent core in each absorbent article in the array of absorbent articles has a front portion extending in the longitudinal direction (Y) from a transverse centre line of each absorbent article to the front core edge and defining a front core area, and a back portion extending in the longitudinal direction (Y) from the transverse centre line of each absorbent article to the back core edge and defining a back core area,
wherein each absorbent article in the array of absorbent articles has side elastic members located underneath the topsheet and extending along the longitudinal core edges,
wherein each absorbent article in the first subarray has a front core area-to-back core area ratio less than 1.2,
wherein each absorbent article in the second subarray has a front core area-to-back core area ratio larger than 1.2, and
wherein a longitudinal length of a portion of the side elastic members extending between the transverse centre line towards the front core edge of each absorbent article of the first subarray is smaller than a longitudinal length of a portion of the side elastic members extending between the transverse centre line towards the front core edge of each absorbent article of the second subarray.

US Pat. No. 10,888,472

ABSORBENT ARTICLE

Daio Paper Corporation, ...

1. An absorbent article having a crotch portion, and a front side portion and a back side portion extending at a front side and a back side of the crotch portion, respectively, the absorbent article comprising:an absorbent element having an absorbent body provided in a front-back direction range including the crotch portion and a wrapping sheet wrapping the absorbent body,
the wrapping sheet including an intermediate part located at a first side of a front face side and a back face side of the absorbent body and both side parts folded back to a second side of the front face side and the back face side of the absorbent body from the intermediate part, the both side parts of the wrapping sheet being overlapped at the second side, overlapping parts of the both side parts being bonded each other through a hot melt adhesive to form a connecting portion, and
at least a surface of the absorbent body on a connecting portion side being bonded to an internal surface of the wrapping sheet through a hot melt adhesive,
wherein a slit having a predetermined width extends in a front-back direction in the absorbent body in at least the crotch portion, and
the connecting portion of the wrapping sheet extends in a width direction to extend over both sides of the slit in the width direction in the absorbent body,
wherein in the intermediate part of the wrapping sheet, a part across the both sides of the slit in the width direction in the absorbent body is folded back an even number of times, opposing surfaces of a folded part are bonded through a hot melt adhesive, and the folded part is bonded to the absorbent body through a hot melt adhesive.

US Pat. No. 10,888,471

SHAPED NONWOVEN

1. A spunbond nonwoven fabric comprising:a. a first surface on a first side of the fabric and a second surface on a second opposite side of the fabric and at least a first and second visually discernible zone on at least one of the first and second surface, each of the first and second zones having a pattern of three-dimensional features, each of the three-dimensional features defining a microzone comprising a first region and a second region, the first and second regions having a difference in values for an intensive property, and
b. wherein the difference in values for an intensive property for at least one of the microzones in the first zone is different from the difference in values for the intensive property for at least one of the microzones in the second zone, wherein the first surface has a TS7 value of less than about 15 dB V2 rms, and wherein the second surface has a different TS7 value than the first surface.

US Pat. No. 10,888,470

ABSORBENT REUSABLE CLOTHING AND UNDERGARMENTS

RSD HOLDINGS LIMITED, Au...

1. An absorbent garment comprising:an undergarment comprising one or more of elastic cords, elastic waist bands, and elastic fabric panels including trunk/leg panels; and
an absorbent pouch assembly inseparably attached to the undergarment operating as a pouch retainer to support the absorbent pouch assembly in connection with a human body when in use, the absorbent pouch assembly comprising
an interior,
an inner aspect configured to be positioned close to or in contact with a discharge area of the human body, the inner aspect comprising at least one shaped panel comprised of a wicking, hydrophilic, and permeable knitted or woven textile that includes elastic fibers,
a flexible absorbent pad having a base, the absorbent pad being in contact with the inner aspect, the absorbent pad having a wicking, hydrophilic, and permeable fluid-absorbent composition,
an external aspect disposed opposite the inner aspect with respect to the human body when in use, and
at least one outer-shaped panel sealing the interior of the absorbent pouch assembly at the external aspect, the at least one outer-shaped panel being a stretchable, woven and conformable textile including elastic fibers and permeated by a fluoracrylate copolymer composition to produce a waterproof, gas-permeable permeated textile,
wherein the garment has a nominal capacity for holding an amount of released fluid of between 30 ml and 500 ml.

US Pat. No. 10,888,469

ABSORBENT ARTICLE WITH RAISABLE TOPSHEET

1. An absorbent article for personal hygiene having a front edge and a back edge notionally defining a longitudinal axis extending from the middle of the front edge to the middle of the back edge, the absorbent article comprising:a garment-facing side comprising a liquid impermeable backsheet;
a wearer-facing side comprising a liquid permeable topsheet;
an absorbent core between the topsheet and the backsheet, the absorbent core comprising an absorbent material;
a chassis comprising the absorbent backsheet and the absorbent core;
a pair of elasticized barrier leg cuffs, each barrier leg cuff defined by a proximal edge attached to the chassis of the article and a terminal edge that can be raised away from the chassis; wherein the topsheet comprises a raisable region attached to the barrier leg cuffs at a position away from the proximal edges of the barrier leg cuffs, so that when the barrier leg cuffs are raised away from the chassis, the raisable region is lifted up by the barrier leg cuffs and an empty volume is formed between the raisable region and the chassis and the raisable region is defined by a front side, a back side and two longitudinally-extending sides, wherein the longitudinally-extending sides are at least partially attached to the barrier leg cuffs and the front side and the back side are at least partially attached to the chassis; and
a front waist cap adjacent the front edge of the article;
a back waist cap adjacent the back edge of the article; wherein the front side and back side of the raisable region are respectively attached to the front waist cap and the back waist cap so that the front waist cap and the back waist cap are at least partially raised simultaneously with the raisable region of the topsheet; andwherein the length of the wearer-facing side of the article is shorter than the length of the garment-facing side of the article, as measured along the longitudinal axis.

US Pat. No. 10,888,468

DISPOSABLE WEARING ARTICLE

UNICHARM CORPORATION, Eh...

1. A disposable wearing article having a vertical direction and a lateral direction, comprising:a front waist region;
a rear waist region;
a crotch region extending between the front waist region and the rear waist region; and
an absorbent panel having a liquid absorbent core extending to the front waist region and the rear waist region centering on the crotch region, wherein
a plurality of linear front waist elastic member contractible in the lateral direction is disposed in the front waist region,
the front waist elastic members include a first elastic member positioned adjacent to an outer side of a front end edge of the liquid absorbent core in the vertical direction, a second elastic member positioned adjacent to an inner side in the vertical direction of the front end edge, and a third elastic member positioned adjacent to an inner side in the vertical direction of the second elastic member,
a contractile force of the first elastic and the second elastic members is weaker than a contractile force of the third elastic member, and
in the front waist elastics of the front waist region, an elongation rate of the first elastic member is lower than an elongation rate of the second elastic member and the third elastic member.

US Pat. No. 10,888,467

SENSOR FOR ABSORBENT ARTICLE

Medline Industries, Inc.,...

1. An absorbent article with a wetness detection system comprising:an inner layer and an outer layer;
wherein the inner layer is a hydrophilic material and the outer layer is a hydrophobic material;
an absorbent layer positioned between the inner layer and the outer layer;
a plurality of conductive ink lines printed on the outer layer;
a wetness indicator positioned in between the plurality of conductive lines; and
an indicator device coupled to the absorbent article that contacts the plurality of conductive ink line.

US Pat. No. 10,888,466

ABSORBENT CORES AND METHODS FOR FORMING ABSORBENT CORES

Kimberly-Clark Worldwide,...

1. A method of forming a pulpless absorbent core comprising:moving a foraminous forming surface in a machine direction, the foraminous forming surface having unmasked portions and masked portions, and wherein the un-masked portions define an absorbent core region of the foraminous forming surface;
depositing particulate material at a velocity of less than 1200 meters per minute through a particulate material inlet and at the foraminous forming surface in the absorbent core region while applying a vacuum to the foraminous forming surface;
depositing a second amount particulate material at a velocity of less than 1200 meters per minute through a second particulate material inlet and at the foraminous forming surface in the absorbent core region while applying a vacuum to the foraminous forming surface;
and prior to depositing the second amount particulate material, applying adhesive to the deposited first amount of particulate material;
wherein the absorbent core region comprises:
a front core region spanning a front third of the absorbent core region;
a rear core region spanning a rear third of the absorbent core region; anda crotch region disposed between the front core region and the rear core region and spanning a middle third of the absorbent core region, the crotch region having a cross-machine direction width that is less than a width of the front core region and less than a width of the rear core region;wherein the front core region trails the rear core region in the machine direction; and
wherein the masked portions of the foraminous forming surface block airflow through the foraminous forming surface to cause greater than 40% of the particulate material deposited in the absorbent core region to locate in the front core region.

US Pat. No. 10,888,465

SURGICAL RECOVERY

1. A surgical recovery process comprised of the steps:completing a surgical procedure during which an area of skin is detached from an underlying substrate;
massaging the area of skin for one to two days after the surgical procedure to express fluid;
assessing a muscular aspect of the underlying substrate to determine a location of a muscle and an orientation of a fiber of the muscle;
preparing a kinetic tape to cover a section of the area of skin;
adhering a first end of the kinetic tape adjacent to the area of skin;
stretching the kinetic tape over the area of skin; and
attaching the entire kinetic tape to the area of skin to pull the area of skin into a proper position to allow the area of skin to reattach to the underlying substrate during a healing process.

US Pat. No. 10,888,464

PRESSURE SENSOR FOR MEASURING PRESSURE APPLIED BY A BANDAGE OR STOCKING

VEINSENSE LTD, Heathfiel...

1. A sensor suitable for measuring the pressure applied by a bandage, the sensor comprising an elongate strip having a sensor region, the sensor region comprising:a base plate;
a top plate;
a compressible spacer positioned between the base plate and the top plate; and,
an electronic sensing apparatus configured to detect distance between the top plate and the base plate,
wherein the top plate is arranged to compress the compressible spacer and arranged such that the bandage exerts a force on the surface of the top plate perpendicular to the surface when the sensor is positioned between the bandage and a limb,
wherein the width of the top plate is calculated according to the equation:
R=(H/2)+(W2/8×H)
where R is the radius of the limb around which the bandage is to be wrapped, H is a gap between the bandage and the centre of the surface of the top plate when wrapped around the limb and W is the width of the top plate.

US Pat. No. 10,888,463

VISCOELASTIC MEDICAL ARTICLE

3M INNOVATIVE PROPERTIES ...

1. A medical article comprising:a machine direction (MD) and a cross-machine direction (CMD);
a support layer;
a viscoelastic layer coupled to the support layer, wherein the viscoelastic layer is discontinuous in at least one of the MD and the CMD, wherein the viscoelastic layer recovers, in at least one of the MD and the CMD, at least 70% of its deformation after 48 hours at room temperature after being strained to 50% elongation,
such that the medical article has, at room temperature, in at least one of the MD and the CMD, a first tensile stiffness T1 at a first strain rate S1 applied in the at least one of the MD and the CMD and a second tensile stiffness T2 at a second strain rate S2 applied in the at least one of the MD and the CMD,
wherein the ratio of S1/S2 is at least 100,
wherein S1 is no greater than 500 cm/min, and
wherein the ration of T1/T2 is at least 1.5 and no greater than 10.

US Pat. No. 10,888,462

ULTRASONIC WAVE GENERATION DEVICE FOR HEARING RECOVERY TREATMENT

SHENZHEN INSTITUTES OF AD...

1. An ultrasonic wave generation device for performing a hearing recovery treatment, comprising: a wearing part and an ultrasonic wave generation part provided on the wearing part;wherein the ultrasonic wave generation part comprises: a reference time-delay determination module, an emission sequence parameter determination module and an ultrasonic transducer module, wherein the ultrasonic transducer module comprises an activation control unit provided on the wearing part and a plurality of array elements arranged in an array, and each array element is electrically connected with the activation control unit via an independent line;
the reference time-delay determination module is configured to calculate a reference time delay of each array element when emitting an excitation pulse signal;
the emission sequence parameter determination module is configured to determine an emission sequence parameter of each array element; and
the activation control unit is configured to control, according to the reference time delay and the emission sequence parameter of each array element, each array element to generate the excitation pulse signal, so that the excitation pulse signals emitted by the respective array elements are focused on a target area.

US Pat. No. 10,888,461

LASER THERAPEUTIC DEVICE FOR OPHTHALMOLOGY

OPTOTEK D.O.O., Ljubljan...

1. An ophthalmic laser therapeutic device for performing surgical treatments of selective laser trabeculoplasty or capsulotomy and other treatment in ophthalmology, the device comprising:a laser producing a laser, the laser source comprising a resonator comprising a passive Q-switch having a Miller Index orientation of <110> for pulsing the laser;
a VCSEL (101) source for pumping the pulsed laser utilizing an end pumping technique; and
a polarizer (107) for linear polarization of the light pulses, wherein
the resonator length is less than or equal to 50 mm, and the duration of laser pulses comprises values between 0.5 ns and 3 ns.

US Pat. No. 10,888,460

DUAL BLADE OPHTHALMOLOGIC SURGERY DEVICE

MICROSURGICAL TECHNOLOGY,...

1. A dual blade device useable for performing an ab interno procedure within a human eye to remove a strip of trabecular meshwork tissue, said device comprising:a handle configured to be grasped by an operator's hand;
an elongate probe shaft that extends from the handle along a longitudinal axis to a distal end;
a tip portion that extends along a second longitudinal axis from the distal end of the probe shaft to form an angle of approximately 30 degrees to approximately 90 degrees relative to the longitudinal axis of the shaft, the tip portion being configured to penetrate through the trabecular meshwork tissue and having a transverse width, a top surface, a bottom surface and a terminal end, the transverse width of the tip portion being narrowest at its terminal end;
first and second spaced apart cutting edges configured to simultaneously cut tissue that passes over the top surface of the protruding tip and into contact with the first and second spaced apart cutting edges; and
a top edge that traverses above an area between the first and second spaced apart cutting edges;
wherein;
a) the top surface of the tip portion extends from the terminal end of the tip portion to the first and second spaced apart cutting edges;
b) a distal portion of the probe, inclusive of the tip portion, is sized to pass through an incision formed in the eye;
c) the tip portion is sized to fit within Schlemm's Canal of the human eye and, when so positioned, is advanceable through Schlemm's Canal with trabecular meshwork tissue passing over its top surface and into contact with the first and second spaced apart cutting edges;
d) the first and second spaced apart cutting edges are formed on generally opposite edges of the distal end of the elongate probe shaft and are separated by a distance D; and
e) the first and second spaced apart cutting edges face towards the second longitudinal axis of the tip portion.

US Pat. No. 10,888,459

MICROFEMTOTOMY METHODS AND SYSTEMS

AMO Development, LLC, Sa...

1. A method for performing a laser-assisted treatment of an eye having a lens capsule, the method comprising:forming an anchoring capsulotomy in the lens capsule by using a laser to incise the lens capsule, the anchoring capsulotomy being configured to accommodate a drug eluting plug; and
removably coupling the drug eluting plug to the anchoring capsulotomy, wherein the drug-eluting plug includes at least one cap on a body, wherein a portion of the body of the drug eluting plug is removably fitted through the anchoring capsulotomy to retain the drug eluting plug's position relative to the lens capsule, wherein the portion the body of the drug-eluting plug that passes through the anchoring capsulotomy includes pores configured for dispersion of a drug which is otherwise contained within the drug-eluting plug.

US Pat. No. 10,888,458

COMBINED NEAR INFRARED IMAGING AND VISIBLE IMAGING IN A COMPACT MICROSCOPE STACK

Alcon Inc.

1. A method for performing ophthalmic surgery, the method comprising:scanning a surgical field using an optical coherence tomography (OCT) scanning system coupled to a surgical microscope, the surgical microscope used to view visible light from the surgical field, wherein the OCT scanning system projects near-infrared (NIR) light onto the surgical field for the scanning of the surgical field;
diverting, using a multi-beam splitter in an optical path transmitting the visible light to a first ocular of the surgical microscope, a first portion of the NIR light and a second portion of the visible light to an imaging path of the surgical microscope;
splitting, using a dichroic mirror in the imaging path, the first portion of the NIR light from the second portion of the visible light;
generating an infrared (IR) image of the surgical field from the first portion of the NIR light using an IR camera, the IR image indicating a location in the surgical field of the scanning of the surgical field; and
generating a visible image of the surgical field from the second portion of the visible light using a visible camera, wherein the visible camera and the IR camera are positioned in the plane.

US Pat. No. 10,888,457

DETACHABLE MINIATURE MICROSCOPE MOUNTED KERATOMETER FOR CATARACT SURGERY

1. A keratometer for intra-surgery measurements mounted under a surgical microscope, comprising:a Placido ring illuminating a patient's eye;
a video camera;
a beamsplitter directing a Purkinje image of the Placido ring to the video camera;
a fixation light directing a beam for patient eye fixation, fixation confirmation or creating a red reflex effect to enhance IOL imaging and cataract visualization;
a processor configured to determine the refractive characteristics and keratometer parameters of the patient's eye and to outline IOL features to help IOL alignment; and
a digital display displaying the keratometer parameters and surgical guidance information for a surgeon,
wherein 0.02-30% of the Purkinje image is defined as a small Region-of-Interest window and is used to extract information on the Purkinje image for high frames-per-second measurement and averaging.

US Pat. No. 10,888,456

SURGICAL CASSETTE

1. A surgical cassette, comprising:a front plate having a top portion, a bottom portion, and a front surface;
wherein the front plate comprises a handle and thumb shield on the front surface located between the top portion and the bottom portion,
wherein the thumb shield is located above the handle and comprises a first surface and a second surface,
wherein the first surface is a horizontally extending raised surface to constrain a thumb from extending above the top portion, the horizontally extending raised surface is raised with respect to the front surface; and
wherein the second surface is a vertically extending raised surface that extends from the first surface to a top of the handle, the vertically extending raised surface is raised with respect to the front surface.

US Pat. No. 10,888,455

IMAGE-GUIDED DELIVERY OF OPHTHALMIC THERAPEUTICS

THE CLEVELAND CLINIC FOUN...

1. A method for image-guided delivery of a therapeutic to an eye comprising:generating at least one optical coherence tomography (OCT) image of the eye;
determining a position of a distal end of a therapeutic delivery mechanism from the at least one OCT image of the eye;
delivering the therapeutic to the eye through the therapeutic delivery mechanism according to the determined position of the distal end of the therapeutic delivery mechanism;
monitoring the delivery of the therapeutic from the at least one OCT image; and
controlling the therapeutic delivery system according to the at least one OCT image.

US Pat. No. 10,888,454

PIEZOELECTRIC FLUID DISPENSER

Kedalion Therapeutics, In...

1. A dispensing apparatus, comprising:an ampoule containing a liquid to be dispensed and having a first portion and a second portion, wherein the first portion defines one or more apertures through a side wall of the first portion; and
an assembly which is configured to impart an oscillation onto the side wall such that a stream of the liquid is dispensed from the one or more apertures;
wherein the assembly is configured to engage with the side wall of the first portion partially, but not completely, around a circumference of the first portion.

US Pat. No. 10,888,453

OCULAR DELIVERY SYSTEMS AND METHODS

SIGHT SCIENCES, INC., Me...

1. An implant-free method for treating conditions of the eye comprising:advancing a conduit within an eye by actuating a drive assembly in a first direction; and
delivering a fluid through the conduit and into the eye by actuating the drive assembly in a second direction opposite the first direction.

US Pat. No. 10,888,452

WEARABLE THERMAL GEL-PACK

The Gym Lombard LLC, Boy...

1. A wearable thermal gel-pack comprising:a gel-pack body having:
a first portion including an inner surface and defining a gel cavity, the first portion encapsulating a gel material within the gel cavity; and
a second portion with a container with a first member coupled to the first portion of the gel-pack body and having a proximal end, a distal end opposing the proximal end of the first member of the second portion, having opposing sides, and a continuous outer perimeter edge surrounding the opposing sides of the second portion and the distal end of the first member, a second member having a lower end pivotally coupled at the proximal end of the first member to form a joint, having a distal end opposing the lower end of the second member, having opposing sides, a continuous outer perimeter edge surrounding the opposing sides and the distal end of the second member, and with an outer surface opposing the inner surface of the first portion of the gel-pack body, and a container cavity defined by the first and second members of the container, the container cavity juxtaposed to and fluidly uncoupled to the gel cavity, the first and second members of the container having a closed position with the continuous outer perimeter edges thereon in a watertight configuration with respect to one another and operably configured to pivotally translate about the joint to have an open position:
with a container opening continuously defined by and spanning the continuous outer perimeter edges on the first and second members of the second portion and with the continuous outer perimeter edges on the first and second members of the second portion separated from one another around the opposing sides and the distal ends of the first and second members of the second portion until reaching the joint;
with a portion of the container opening disposed proximal to the distal ends of the first and second members of the second portion in fluid communication with the container cavity; and
with the first and second members each with a side coupling material having opposing ends coupled to the first and second members of the second portion, respectively; and
a strap couplable to the outer surface of the second member at a location along a strap length and operably configured to surround a portion of a user's limb.

US Pat. No. 10,888,451

ORAL DEVICE FOR PREVENTING SLEEP APNEA AND A METHOD OF MANUFACTURING

Jordan University of Scie...

1. A device, comprising:an upper plate having a plurality of anatomical data points adapted to conform to a biting surface of maxilla teeth of a user;
a lower plate having a plurality of anatomical data points adapted to conform to a biting surface of mandible teeth of the user;
an indexed bite plate along each side of two posterior, upward-facing surfaces of the lower plate, wherein each indexed bite plate is shaped to accept cusp tips of a downward-facing surface of the upper plate; and
two S-shaped rods, each S-shaped rod connecting posterior portion of the upper plate and an anterior portion of the lower plate, wherein each S-shaped rod has a first curve adjacent the posterior portion of the upper plate and a second curve adjacent the anterior portion of the lower plate, the two curves defining a non-linear S-shaped.

US Pat. No. 10,888,450

MENSTRUAL CUPS AND METHODS OF USE

LELO Inc., San Jose, CA ...

1. A menstrual cup, comprising:a rim having an upper portion, a lower portion, a first end, a second end, and an exterior surface, the rim defining a first lip adjacent the upper portion, the first lip extending along the exterior surface of the rim, the rim comprising silicone; and
a receptacle disposed adjacent and attached to the lower portion of the rim, the receptacle defining an interior surface, the interior surface comprising a textured pattern, the receptacle comprising silicone, wherein a slope of a first end of the receptacle adjacent to the first end of the rim is less than a slope of a second end of the receptacle adjacent to the second end of the rim;
wherein the first end of the rim extends away from the receptacle.

US Pat. No. 10,888,449

NASAL DEVICE

Shu-Chen Tsai, Taipei (T...

1. A nasal device for use while breathing and adapted for insertion within a human nasal cavity, the device comprising:a main body being tubular in shape having a hollow structure which extends from the end of front side to the end of rear side, wherein the main body is insertable into a nasal cavity; and
a front opening portion at the end of a front side of the main body and is configured to open the hollow structure towards the outside of the nasal device; and
a rear opening portion at the end of a rear side of the main body and is configured to open the hollow structure towards the outside of the nasal device; and
a pressing portion placed at the rear end of the main body and can move sideways from the rear end view in between a protruding position of the main body and an overlapping position that overlaps with the hollow structure,
wherein the main body comprises a plurality of internal concave parts on an inner surface surrounding the hollow structure, a plurality of external concave parts and a plurality of connecting holes, further wherein the external concave part is formed by concaving on an outer surface surrounding the hollow structure, and the connecting hole connects to the outside by having one end at the internal concave part and the other end at the external concave part.

US Pat. No. 10,888,448

SUPPORTER

KOWA COMPANY, LTD., Nago...

1. A band-shaped supporter, comprising:a back-contact section configured to be brought into contact with a back portion of a wearer;
a plurality of protruding sections which are disposed on both sides of the back-contact section, respectively, and in each of which a stretchable portion having stretchability in a longitudinal direction is disposed in contact with the back-contact section;
a pair of auxiliary band sections which includes two band-shaped members having stretchability in a longitudinal direction such that the two band-shaped members are fixed at ends and intersect one another on the back-contact section, and that a pair of annular rings are slidably disposed at the band-shaped members, respectively;
a pair of adjustment band sections which includes two band-shaped members having stretchability lower than the stretchability of the pair of auxiliary band sections such that each of the two band-shaped members in the pair of adjustment band sections is loosely inserted into a respective one of the annular rings in the pair of auxiliary band sections, and has one end fixed to a portion except for the stretchable portion of each of the plurality of protruding sections and hooks of a hook-and-loop fastener disposed at the opposite end; and
a band-shaped support band section which includes a band-shaped member having stretchability in a longitudinal direction and is fixed to the back-contact section such that the band-shaped member of the band-shaped support band section does not overlap an intersection portion of the two band-shaped members of the pair of auxiliary band sections on the back-contact section, and hooks of a hook-and-loop fastener are disposed at opposing end portions of the band-shaped member of the band-shaped support band section.

US Pat. No. 10,888,447

ENERGY RETURN ORTHOTIC SYSTEMS

1. A bi-layer orthotic system comprising: a base layer having a distal toe portion, a mid-portion and a proximal end portion; a single upper layer integrally formed with said base layer, said upper layer having a proximal heel upper layer portion and a bi-furcated distal portion, said bi-furcated distal end of said upper layer integrally coupled at first and second attachment points to the distal toe portion of the base layer, wherein the heel upper layer portion is elevated by a therapeutic angle over said base layer to form a rear spring area and further wherein said distal toe portion of the base layer includes a central area cut into said distal toe portion, said central area having a bifurcated distal portion with first and second central area attachment points integrally formed with said base layer and a proximal portion deformable between an elevated position and a lowered position.

US Pat. No. 10,888,446

SYSTEMS AND METHODS FOR PERFORMING BARIATRIC SURGERY

Boehringer Technologies, ...

1. A system for sizing the stomach of a patient for a bariatric procedure, said system comprising:a suction controller configured for producing controlled suction from a source of suction;
a non-expandable instrument configured to be coupled to said suction controller, said instrument being a single elongated member forming a sizing tube formed of a flexible non-expandable material having a predetermined outside diameter configured for introduction through the esophagus into the stomach of the patient so that a portion of said sizing tube is disposed along the lesser curvature of the patient's stomach, said sizing tube having a longitudinal axis, a hollow interior defining a passageway, a proximal end portion, a tip having a distal end that is unencumbered, and a plurality of apertures disposed about the periphery of said distal end portion, said plurality of apertures being directed in a plurality of different radial directions from said longitudinal axis and being in fluid communication with said passageway, plural ones of said apertures extending along a portion of the lesser curvature of the patient's stomach when said sizing tube is located within the patient's stomach, whereupon controlled suction is applied to the hollow interior of said sizing tube and through said apertures to pull the lesser curvature of the patient's stomach into engagement with a portion of said sizing tube and contemporaneously therewith to pull other portions of the patient's stomach adjacent to said sizing tube towards portions of said sizing tube not facing the lesser curvature of the patient's stomach to anchor said sizing tube in place without the use of any expandable member to hold said sizing tube in place and to produce a suction-created visually perceptible delineation line on the exterior of the patient's stomach along a portion of the periphery of said sizing tube facing the greater curvature of the patient's stomach to serve as a guide enabling the patient's stomach to be sized along said suction-created visually perceptible delineation line and with said controlled suction as applied by said apertures serving as the sole means anchoring said sizing tube in place;
wherein said suction controller is configured to apply controlled suction to said hollow interior of said sizing tube to result in a force in a range of 0.05 to 200 pounds anchoring said sizing tube in position within the patient's stomach;
wherein said sizing tube is configured to apply a suction force per unit length within the patient's stomach at the location of said apertures when said controlled suction is applied to said sizing tube, whereupon the suction force applied per unit length is in a range of 0.02 to 21 pounds per inch based upon an aperture area of 1.2 square inches.

US Pat. No. 10,888,445

APPARATUS AND METHOD FOR STABILIZATION OF PROCEDURAL CATHETER IN TORTUOUS VESSELS

RAM MEDICAL INNOVATIONS, ...

1. A percutaneous intervention system comprising:a bifurcated catheter comprising a first procedural lumen and a second stabilization lumen at a distal end, wherein the bifurcated catheter insertable through a first percutaneous access and guidable to the location of an access to a treatment site;
a procedural catheter slideably insertable through the first procedural lumen and configured to be delivered to the treatment site for a catheter intervention procedure; and
a stabilization wire insertable through a second percutaneous access,
wherein a distal end of the stabilization wire is configured to be captured by a snare wire slidably insertable through the stabilization lumen of the bifurcated catheter and pulled out of a proximal end of the bifurcated catheter at the first percutaneous access while a proximal end of the stabilization wire is outside the second percutaneous access;
wherein the stabilization wire is configured to provide an end to end tension capability on application of a tension between the proximal end and distal end of the stabilization wire,
wherein the stabilization wire is configured to stabilize the bifurcated catheter when tension is applied between the proximal end and distal end of the stabilization wire to provide the end to end tension capability, and
wherein the procedural catheter is slideably insertable through the first procedural lumen and wherein the procedural catheter is configured to be stabilized during access to the procedural site and during procedures by the stabilized, bifurcated catheter.

US Pat. No. 10,888,444

ESOPHAGEAL STENT INCLUDING A VALVE MEMBER

BOSTON SCIENTIFIC SCIMED,...

1. An expandable stent, comprising:a tubular scaffold formed of one or more interwoven filaments, the tubular scaffold including an inner surface; and
a flexible valve extending radially inward from the inner surface of the scaffold;
wherein the valve is configured to shift between a closed configuration and an open configuration;
wherein the one or more filaments of the scaffold bias the valve to the closed configuration while in a nominally deployed state,
wherein the tubular scaffold includes a first tapered region and a second tapered region, and wherein the valve is positioned between the first tapered region and the second tapered region.

US Pat. No. 10,888,443

DEVICE FOR HOLDING PLAQUE TO BLOOD VESSEL WALL

Intact Vascular, Inc., W...

1. A device for holding plaque against a blood vessel wall, the device comprising:a self-expanding tubular body having a longitudinal axis and radially expandable from a compressed state toward an expanded state, the tubular body comprising:
a plurality of laser cut struts forming a distal circumferential ring comprising a first plurality of zig-zags concentric with a proximal circumferential ring comprising a second plurality of zig-zags,
the first plurality of zig-zags comprising:
first distally-facing bends at a first longitudinal position;
second distally-facing bends at a second longitudinal position distal to the first longitudinal position; and
third proximally-facing bends at a third longitudinal position proximal to the first longitudinal position and the second longitudinal position,
the second plurality of zig-zags comprising:
first proximally-facing bends at a fourth longitudinal position;
second proximally-facing bends at a fifth longitudinal position proximal to the fourth longitudinal position; and
third distally-facing bends at a sixth longitudinal position distal to the fifth longitudinal position and the fourth longitudinal position and proximal to the third longitudinal position and the first longitudinal position,
the distal circumferential ring and the proximal circumferential ring longitudinally spaced by a plurality of bridge members, each said bridge member of the plurality of bridge members coupled to one of the third proximally-facing bends at the third longitudinal position and one of the third distally-facing bends at the sixth longitudinal position, each said bridge member of the plurality of bridge members comprising:
a first V-shaped barb;
a second V-shaped barb; and
an eyelet longitudinally between the first V-shaped barb and the second V-shaped barb,
the first V-shaped barb and the second V-shaped barb each oriented in a same circumferential direction perpendicular to the longitudinal axis.

US Pat. No. 10,888,442

SUPER ELASTIC, BIOABSORBABLE ENDOVASCULAR DEVICES

1. An endovascular medical implant device, comprising:a structural frame, elastically deformable from an original structure to a collapsed structure, comprising:
a plurality of elongated straight segments composed of biodegradable metal wire, each of the plurality of elongated straight segments having a length extending between a first segment end and an opposite second segment end,
wherein the biodegradable metal wire constitutes about 80% or greater of the total mass of the device;
a plurality of connectors each composed of nitinol, comprising a straight tube having an outer surface, an opening formed by the outer surface, a first tube end, a second tube end, and a length extending between the first and second tube ends;
a plurality of struts each composed of nitinol in a form selected from the group consisting of a v-shape wire and a u-shape wire, having a first strut end face and a second strut end face,
wherein a total of the nitinol constitutes about 10% or less of the total mass of the device;
a biodegradable polymer in a form of a coating comprising electrospun fibers deposited on a surface of one or more of the plurality of elongated straight segments,
wherein the biodegradable polymer constitutes about 10% or less of the total mass of the device,
wherein one or more pairs of the plurality of elongated straight segments are connected together by the plurality of connectors and the plurality of struts to form the structural frame,
wherein the first segment end of a first one of the plurality of elongated straight segments is connected to the first tube end of a first one of the plurality of connectors, and the first strut end face of a first one of the plurality of struts is connected to the second tube end of the first one of the plurality of connectors, and
wherein the second strut end face of the first one of the plurality of struts is connected to the second tube end of a second one of the plurality of connectors, and the first segment end of a second one of the plurality of elongated straight segments is connected to inserted into the first tube end of the second one of the plurality of connectors.

US Pat. No. 10,888,441

DEVICE FOR ENDOVASCULAR AORTIC REPAIR

Aortic Innovations, LLC, ...

1. A transcatheter heart valve assembly comprising:an outer frame, wherein the outer frame is formed from a metallic material and defines:
a first open cell portion; and
a second open cell portion extending from and continuous with the first open cell portion and defining a construction that differs from the construction of the first open cell portion;
an inner frame that houses a prosthetic heart valve, wherein the inner frame is a graft covering extending around at least a portion of the prosthetic heart valve for providing sealing to the heart valve, wherein the graft covering covers the first open cell portion but does not extend to the second open cell portion,
wherein the outer frame is secured to the graft covering by a plurality of stitches,
a sealing material positioned externally to the outer frame for providing sealing between the outer frame and a patient's anatomical wall to prevent paravalvular leaks, wherein the sealing material includes a plurality of outwardly extending fibers that extend outwardly of the outer frame to form the sealing material, wherein the sealing material is attached to the first open cell portion of the outer frame and extends over at least a portion of the first open cell portion,
wherein the valve assembly is balloon expandable and expansion of the valve assembly presses the sealing material against native leaflets of the aorta of the patient,
wherein the valve assembly has a radially compressed orientation and a radially expanded orientation.

US Pat. No. 10,888,440

INTRAOSSEOUS STENT

CENTRE HOSPITALIER UNIVER...

1. A self-expanding intraosseous stent intended to contain intraosseous cement, wherein the stent comprises a central part and two lateral parts arranged on either side of the central part and extending along the same longitudinal axis, and wherein the central part has a radial force lower than a radial force of the lateral parts, the stent comprising a coaxial meshed outer tube and meshed inner tube, the inner tube having a length greater than the length of the outer tube, so that ends of the inner tube protrude from the outer tube forming the central part of said stent, said ends of the inner tube forming the lateral parts of said stent, and wherein a meshing, density of the inner tube is lower than a meshing density of the outer tube.

US Pat. No. 10,888,439

SYSTEM AND APPARATUS FOR ROBOTIC DEVICE AND METHODS OF USING THEREOF

DEKA Products Limited Par...

1. A robotic assembly control system comprising:an exoskeleton apparatus adapted to be worn by a user comprising at least one tactor motor;
at least one robotic assembly, separate from the exoskeleton, the at least one robotic assembly controlled by the user by way of the exoskeleton;
at least one mobile platform controlled by the user and separate from the exoskeleton and wherein the at least one robotic assembly is attached to the at least one mobile platform,wherein the at least one tactor motor provides feedback related to torque of the shoulder joint on the at least one robotic assembly.

US Pat. No. 10,888,438

SYSTEM FOR TREATING PROXIMAL HUMERAL FRACTURES AND METHOD OF USING THE SAME

Encore Medical, LP, Aust...

1. A method of positioning a humeral implant within a humeral shaft, comprising:providing a humeral implant having at least one hole defined therethrough;
positioning a longitudinal rod member for receipt within a reamed medullary canal of the humeral shaft;
coupling a jig assembly having a plurality of holes to said longitudinal rod member with a fastener to fix the position of the jig assembly with respect to the longitudinal rod member; and
inserting the longitudinal rod member within the humeral shaft;
inserting a drill bit through one of said plurality of holes in said jig assembly and into a corresponding aligned hole in the longitudinal rod member to form a first hole in the humeral shaft;
after forming the first hole in the humeral shaft, removing the longitudinal rod from the humeral shaft and inserting a portion of the humeral implant including the at least one hole therethrough into the reamer medullary canal of the humeral shaft; and
coupling the jig assembly to the humeral implant with the fastener to align the at least one hole defined through the humeral implant with the first hole drilled in the humeral shaft such that the jig assembly assists in locating the position of the humeral implant in the humeral shaft.

US Pat. No. 10,888,437

METHODS AND APPARATUS FOR INTERVERTEBRAL DISC PROSTHESIS INSERTION

Simplify Medical Pty Ltd,...

1. A system for inserting an intervertebral prosthesis into a space between two adjacent vertebrae, the system comprising:an intervertebral prosthesis having two endplates movable with respect to one another and a core disposed between the two endplates, wherein each of the two endplates include an outer vertebral body facing surface, an inner surface facing the other endplate and two lateral side surfaces therebetween;
a prosthesis grasping device comprising:
an elongate rigid shaft having a proximal end and a distal end;
a grasping member coupled with the distal end for releasably grasping the two endplates of the intervertebral prosthesis, the grasping member comprising movable opposing jaws configured to move closer together or farther apart in the lateral direction to simultaneously grasp around the opposite lateral sides of the two endplates such that the endplates are constrained from articulating with respect to one another; and
at least one prosthesis pusher device which is discrete from the prosthesis grasping device, the prosthesis pusher device having a distal end configured to push against the endplates of the intervertebral prosthesis, wherein after the intervertebral prosthesis is inserted into the space, the at least one prosthesis pusher device is used to engage and push the prosthesis farther into the space.

US Pat. No. 10,888,436

TIBIAL TRAY IMPACTOR

Zimmer, Inc., Warsaw, IN...

1. An impactor tool comprising:a handle;
an impactor coupled to the handle;
a lock extendable from the impactor to engage an implant and retractable into the impactor to secure the lock and the impactor to the implant;
an actuator protruding from the impactor and coupled to the lock, the actuator comprising:
a cam defined by a channel extending through the actuator; and
a pin coupled to the lock and disposed within the cam channel, the actuator operable along a path defined by the cam and the pin to extend the lock from the impactor and to retract the lock entirely into the impactor.

US Pat. No. 10,888,435

MODULAR INSERTER FOR ANTERIOR CERVICAL CAGE

SPINE WAVE, INC., Shelto...

1. A modular inserter assembly for use in inserting an interbody fusion cage between a superior vertebra and an inferior vertebra, the superior vertebra including an inferior endplate and a vertebral body, the inferior vertebra including a superior endplate and a vertebral body, the superior and inferior endplates defining a disc space therebetween, said modular inserter assembly comprising:a depth stop and a modular inserter tip releasably attached to said depth stop, said modular inserter tip including a cage attachment surface for releasable attachment to said interbody fusion cage, said depth stop including a movable stop axially movable relative to said inserter tip and being sized and configured to engage an exterior surface of one of said vertebrae when said interbody fusion cage is disposed in said disc space, said movable stop being spaced axially from a first location on said modular inserter tip by a selectively adjustable first distance, said modular inserter tip having a distal end and a proximal end, said distal end comprising a pair of flexible latches terminating in a pair of bilateral hooks for releasable attachment to said interbody fusion cage, said first location on said modular inserter tip is said cage attachment surface, each of said hooks comprising a cam cooperatively engageable with a movable portion of said depth stop to cause movement of said hooks toward each other in a manner to allow release from said interbody fusion device.

US Pat. No. 10,888,434

MODULAR SCORING TRIAL FOR ANTERIOR CERVICAL CAGE

SPINE WAVE, INC., Shelto...

1. A disc preparation instrument for use in fusing together a superior vertebra and an inferior vertebra, the superior vertebra including an inferior endplate and a vertebral body, the inferior vertebra including a superior endplate and a vertebral body, the superior and inferior endplates defining a disc space therebetween, the disc preparation instrument comprising:a modular scoring trial and a depth stop, said scoring trial comprising an elongate stem having a distal end and a proximal end and a trial device being supported on the distal end of said stem, said trial device having a proximal end and a distal end, said proximal end being attached to the distal end of said elongate stem, said trial device being sized and configured for insertion into said disc space, said trial device including a scoring element selectively movable from a first position interiorly of said device through an opening in said device to a second position exteriorly of said device for scoring the endplate of one of said vertebrae at a scored location, said depth stop being releasably attached to said elongate stem at an attachment location on said stem, said depth stop being releasably attached to said elongate stem by a ball bearing lock, said depth stop including a movable stop axially movable relative to said stem and being sized and configured to engage an exterior surface of one of said vertebrae when said trial device is disposed in said disc space, said movable stop being spaced axially from a first location on said trial device by a selectively adjustable first distance, said attachment location and said first location being set at a fixed predetermined distance.

US Pat. No. 10,888,433

INTERVERTEBRAL IMPLANT INSERTER AND RELATED METHODS

DePuy Synthes Products, I...

1. An insertion instrument configured to implant an expandable intervertebral implant in an intervertebral space, the insertion instrument comprising:a biasing member;
a drive shaft elongate along a longitudinal direction;
a drive member disposed at a distal end of the drive shaft and configured to: 1) couple to a complementary driven member of the implant, and 2) iterate the intervertebral implant from a collapsed configuration to an expanded configuration;
a securement member arranged relative to the drive shaft such that the securement member is spaced from the drive member along a lateral direction that is perpendicular to the longitudinal direction and such that the drive member is rotatable relative to the securement member to iterate the intervertebral implant from the collapsed configuration to the expanded configuration, the securement member having:
at least one guide rail that has a height along a transverse direction sufficient to 1) reside in a corresponding at least one guide channel of both an inferior endplate and a superior endplate of the implant when the implant is in the collapsed configuration, 2) ride along the implant in the at least one guide channel as the implant expands to the expanded configuration, and 3) remain in the corresponding at least one guide channel of both the inferior endplate and the superior endplate when the implant is in the expanded configuration; and
a collar that is configured to be inserted in a corresponding groove of a coupler of the implant that is supported by the driven member while the drive member is engaged with the driven member; and
an engagement member that is received in the biasing member and threadedly mated with the securement member such that relative rotation between the engagement member and the biasing member in a first direction causes the securement member to travel along the biasing member toward an engaged position in which the securement member is configured to secure to the implant, and relative rotation between the engagement member and the biasing member in a second direction opposite the first direction causes the securement member to travel along the biasing member toward a disengaged position in which the securement member is configured to receive the implant,
wherein the transverse direction is perpendicular to each of the longitudinal direction and the lateral direction; and
wherein the securement member defines a recess proximal to the collar such that the collar is between the recess and the at least one guide rail with respect to the longitudinal direction, the recess being configured to receive a portion of the coupler of the implant.

US Pat. No. 10,888,432

LORDOTIC ROD-WASHER IMPLANT FOR LUMBO-SACRAL FUSION

Quandary Medical LLC, Wi...

1. A method for placing an implant and forcing the vertebral bodies of the lumbo-sacral junction into a lordotic orientation, comprising:defining a path to and through a sacrum by use of a guide wire, the path of the guide wire having a central axis;
inserting a sacrum anchor into the sacrum over the guide wire;
aligning a washer and distraction rod by placement over the guide wire;
advancing the washer and distraction rod over the guide wire, through the sacrum anchor and into the disc space; and
rotating the distraction rod around the central axis of the path of the guide wire to cause the washer to engage a vertebral body and move the vertebral body into lordosis with respect to the sacrum.

US Pat. No. 10,888,431

EXPANDABLE, ADJUSTABLE INTER-BODY FUSION DEVICES AND METHODS

Spectrum Spine IP Holding...

1. An inter-body fusion device for use in surgery comprising:a first plate having a leading edge, a trailing edge, an upper bone contact surface, an opposed first plate inner surface, and a first plate longitudinal axis;
a second plate having a leading edge, a trailing edge, a lower bone contact surface, an opposed second plate inner surface, and a second plate longitudinal axis,
wherein the first plate is spaced from and overlies the second plate and is positioned such that the first plate longitudinal axis and the second plate longitudinal axis form a device angle therebetween; and
an insert comprising a first member having a leading edge, a trailing edge, an upper plate contact surface and an opposed lower plate contact surface, and a second member having a leading edge, a trailing edge, an upper plate contact surface and an opposed lower plate contact surface, the insert positioned the first plate and the second plate;
wherein movement of the first member longitudinally with respect to the first and second plates increases a distance between a portion of the leading edge of the first plate and a portion of the leading edge of the second plate and wherein movement of the second member longitudinally with respect to the first and second plates increases a distance between a portion of the trailing edge of the first plate and a portion of the trailing edge of the second plate,
wherein the first and second members are separate and operate independently, enabling a user to selectively alter both a distance between the first plate and the second plate and the device angle,
wherein the first member defines a first bore configured to engage a threaded shaft, wherein rotation of the threaded shaft in a first direction moves the first member proximally and rotation of the threaded shaft in a second direction moves the first member distally, and
wherein the second member defines a second bore that extends longitudinally therethrough, the second bore configured to engage a second threaded shaft, wherein rotation of the second threaded shaft in a first direction moves the second member proximally and rotation of the second threaded shaft in a second direction moves the second member distally.

US Pat. No. 10,888,430

EXPANDABLE/VARIABLE LORDOTIC ANGLE VERTEBRAL IMPLANT AND READING SYSTEM THEREFOR

1. An implant comprising:a pair of endplates having a posterior surface, an anterior surface, and opposing sides, wherein the pair of endplates are movably attached to one another by a sliding dovetail joint located on the posterior surface of the implant, and further wherein a range of motion of the pair of endplates at the posterior surface is less than a second range of motion of the pair of endplates at the anterior surface;
at least one structurally encoded member; and
a wedge component positioned at least partially between said pair of endplates, wherein the positioning of the wedge component modifies the height and lordotic angle of the implant.

US Pat. No. 10,888,429

THREE-DIMENSIONAL LATTICE STRUCTURES FOR IMPLANTS

HD LIFESCIENCES LLC, Wob...

1. A structure for use in medical implants, the structure comprising:a three-dimensional lattice structure configured to extend between two adjacent bony structures and provide sole mechanical spacing between the two adjacent bony structures, the three-dimensional lattice comprising:
a plurality of repeating unit cells; and
a plurality of fluidly interconnected openings disposed within a volume of the three-dimensional lattice, the plurality of fluidly interconnected openings comprising a first group of openings comprising a first width and a second group of openings comprising a second width, the second width being greater than the first width and number of openings in the second group of openings being a ratio of about 1:1 to 1:25 of number of openings in the first group of openings.

US Pat. No. 10,888,428

ADDITIVE MANUFACTURING DEVICE FOR BIOMATERIALS

University of Notre Dame ...

1. A biomaterial delivery system for printing a tissue engineering construct inside a patient's body, the biomaterial delivery system comprising:a robotic surgical system having an articulating arm and an end effector coupled to a distal end of the articulating arm, the end effector configured to have at least three degrees of movement being controlled by the robotic surgical system; and
an additive manufacturing device comprising:
a frame releasably mounted to the end effector;
a first mechanical transmission element operatively connected to the frame and engaged with the end effector so that the end effector may control the operation of the first mechanical transmission element;
a biomaterial reservoir selectively removably connected to the frame, the biomaterial reservoir adapted to hold biomaterial;
a syringe pump capable of generating pressure in the reservoir, the syringe pump operatively coupled to the first mechanical transmission element so that biomaterial may be expelled from the biomaterial reservoir when the first mechanical transmission element is operated by the end effector;
a shaft operatively connected to a discharge end of the biomaterial reservoir, the shaft adapted to transport biomaterial therethrough, the shaft configured to be at least partially inserted into a patient's body; and
a nozzle operatively connected to a discharge end of the shaft, the nozzle configured to be inserted into the patient's body and discharge biomaterial therein;
wherein the nozzle is operatively coupled to the end effector such that, on command of the robotic surgery system, the end effector moves the nozzle while depositing biomaterial to print a tissue engineering construct inside the patient's body.

US Pat. No. 10,888,427

DISTAL REAMER FOR USE DURING AN ORTHOPAEDIC SURGICAL PROCEDURE TO IMPLANT A REVISION HIP PROSTHESIS

DePuy Synthes Products, I...

1. A surgical instrument assembly operable to ream an intramedullary canal of a patient's femur during a surgical procedure to implant a distal stem component of a modular orthopaedic hip prosthesis, comprising:a distal reamer having (i) a cutting head that includes a plurality of helical cutting flutes arranged in a geometry that corresponds with the geometry of the distal stem component, and (ii) a female drive socket comprising a female hex drive socket, and
an extension tool having (i) an elongated shaft (ii) a connector at a proximal end of the elongated shaft configured to couple the extension tool to a rotary drive source, and (iii) a drive spline positioned at a distal end of the elongated shaft in, and engaged with, the female drive socket of the distal reamer such that rotation of the extension tool causes rotation of the distal reamer,
wherein the extension tool further has a number of visual markings that correspond to depths of the distal reamer within the intramedullary canal of the patient's femur.

US Pat. No. 10,888,426

MULTI-LAYER SUBSTRATE APPARATUS, SYSTEMS AND METHODS OF ASSEMBLING SAME

The Aerospace Corporation...

1. A multi-layer substrate apparatus comprising:a first layer configured to provide at least one electrical-based property;
a second layer positioned proximate to said first layer, wherein said second layer is configured to provide at least one mechanical-based property;
a third layer positioned proximate to said second layer, wherein said third layer comprises at least one chemical component such that said third layer is enabled to regulate said multi-layer substrate apparatus based, at least in part, on a system that said multi-layer substrate apparatus is being used with;
a fourth layer positioned proximate to said third layer, wherein said fourth layer is configured to provide at least one magnetic-based property; and
a fifth layer positioned proximate to said fourth layer, wherein said fifth layer is configured to provide support based, at least in part, on the system that said multi-layer substrate apparatus is being used with, wherein said fifth layer further comprises a geometric portion that is configured to facilitate at least one process therein.

US Pat. No. 10,888,425

HEART VALVE SEALING DEVICES AND DELIVERY DEVICES THEREFOR

Edwards Lifesciences Corp...

1. A valve repair device for repairing a native valve of a patient, the valve repair device comprising:a coaption element comprising a fabric;
a pair of paddles connected to the coaption element, wherein the paddles are movable between an open position and a closed position;
wherein the paddles are configured to attach to the native valve of the patient;
wherein the paddles comprise a flexible mesh material connected to an extension member;
wherein the extension member has a round three-dimensional shape;
wherein an inner portion of the flexible mesh material is disposed on a first side of the extension member;
wherein an outer portion of the flexible mesh material is disposed on a second side of the extension member.

US Pat. No. 10,888,424

PROSTHETIC MITRAL VALVE COAPTATION ENHANCEMENT DEVICE

MEDIRA AG, Muri (CH)

1. A prosthetic mitral valve coaptation enhancement device for implanting at the native mitral valve region of a heart, wherein the native mitral valve, having a native annulus and native valve leaflets, can still perform a closing movement, and wherein the prosthetic mitral valve coaptation enhancement device comprising:a main body consisting of a stentframe and a valve element attached thereto, the main body comprising a length and a lumen being defined by a proximal end and a distal end, and configured for placement within the native mitral valve region of the heart, the stentframe being radially compressible to a radially compressed state for delivery into the heart and self-expandable from the compressed state to a radially expanded state, wherein the main body has a sealing section and a valve-bearing section, the valve-bearing section carrying a valve element:
wherein
the shape of the sealing section of the main body, when compressed by the native valve leaflets, has a form that is adapted to the coaptation zone of the native mitral valve during systole, that
in the sealing section of the main body, the radial rigidity of the stentframe is lower than the radial rigidity of the valve-bearing section; and that
the sealing section of the main body is configured such that it is smaller than the native annulus of the heart into which the prosthetic mitral valve coaptation enhancement device is to be implanted and such that it contacts the native leaflets only during systole, thereby sealing the mitral annulus during systole and permitting filling of the ventricle through and alongside the prosthetic mitral valve coaptation enhancement device during diastole, thereby minimizing the gradient between the left atrium and ventricle;
and that the prosthetic mitral valve coaptation enhancement device further comprises at least one substantially rigid anchoring element, which anchoring element is coupled to the main body and is capable to anchor the main body within the native mitral valve region of a heart.

US Pat. No. 10,888,423

LEFT HEART ASSIST DEVICE AND METHOD

Syntach AG, Schaffausen ...

1. A medical device for mimicking at least a portion of left ventricular pump action in a heart of a patient comprising:a first anchor unit configured for implantation in a cardiac vessel of said heart in proximity to a mitral valve (MV) plane;
a second anchor unit configured for implantation at a location spaced apart from said first anchor unit by a distance, and in communication with said first anchor unit; and
a powered force generating unit that generates linear anchor forces that move the first and second anchor units relative to each other, thereby shortening said distance, during successive systolic heart events.

US Pat. No. 10,888,422

PROSTHETIC VALVE WITH FLEXIBLE TISSUE ANCHOR PORTIONS

CARDIOVALVE LTD., Or Yeh...

1. An expandable prosthetic valve configured for implantation within a native heart valve, the prosthetic valve comprising:an expandable annular valve body;
a plurality of ventricular anchoring legs, each ventricular anchoring leg configured to extend radially outward from the expandable annular valve body to a respective terminal leg end; and
a plurality of atrial anchoring arms, each atrial anchoring arm configured to extend radially outward from a respective proximal arm end secured to the expandable annular valve body to a respective terminal arm end,
wherein the expandable prosthetic valve is configured to assume:
a radially compressed state in which the prosthetic valve is configured to be contained at least partially within a prosthetic valve delivery device, and
a radially expanded state in which the expandable prosthetic valve is configured to be anchored within the native heart valve,
wherein at least one atrial anchoring arm includes:
a rigid portion comprising a strut configured to extend in an upstream direction from the proximal arm end of the at least one atrial anchoring arm, and
a flexible portion comprising a structure with multiple curves and being positioned between the rigid portion and the terminal arm end of the at least one atrial anchoring arm, a proximal section of the structure with multiple curves being situated adjacent to the rigid portion of the at least one atrial anchoring arm, wherein at least the proximal section of the structure with multiple curves has a smaller cross-sectional area than the strut of the rigid portion such that the flexible portion is configured for greater flexibility than the rigid portion, and
wherein when the expandable prosthetic valve is in the radially expanded state, the at least one atrial anchoring arm and at least one ventricular anchoring leg are configured to be arranged such that the proximal section of the structure with multiple curves of the at least one atrial anchoring arm and the terminal leg end of the at least one ventricular anchoring leg are substantially equidistant from a longitudinal axis extending through the center of the annular valve body.

US Pat. No. 10,888,421

PROSTHETIC HEART VALVE WITH POUCH

CARDIOVALVE LTD., Or Yeh...

1. Apparatus, comprising:a frame assembly that comprises:
a valve body that circumscribes a longitudinal axis and defines a lumen along the axis;
a plurality of upstream arms that are coupled to the valve body at a first axial level with respect to the longitudinal axis, each of the plurality of upstream arms extending radially outward from the valve body to a respective arm-tip; and
a plurality of downstream legs that are coupled to the valve body at a second axial level with respect to the longitudinal axis, and that extend radially outward from the valve body and toward the plurality of upstream arms;
a plurality of prosthetic leaflets, disposed within the lumen, and arranged to facilitate one-way upstream-to-downstream fluid flow through the lumen, the first axial level being upstream of the second axial level; and
a flexible pouch that defines an interior space therein, the pouch shaped and coupled to the frame assembly such that:
the pouch extends radially outward from the valve body, and
the plurality of upstream arms and the plurality of downstream legs narrow the pouch therebetween to form a narrowed portion of the pouch, so as to define:
an inner portion of the interior space, radially inward from the narrowed portion, and in fluid communication with the lumen, and
an outer portion of the interior space, radially outward from the narrowed portion, and in fluid communication with the inner portion via the narrowed portion.

US Pat. No. 10,888,420

STENTED PROSTHETIC HEART VALVE HAVING A WRAP AND DELIVERY DEVICES

Medtronic Vascular, Inc.,...

1. A stented prosthetic heart valve comprising:a stent frame having a compressed arrangement for delivery within a vasculature and an expanded arrangement for deployment within a native heart valve;
valve leaflets disposed within and secured to the stent frame;
a wrap encircling the stent frame and formed of a flexible material having a first end and a second end; the wrap having a delivery position and a deployed position in which the first end and the second end are positioned closer together as compared to the delivery position; wherein the wrap can be actuated from the delivery position to the deployed position so that the wrap bulges outwardly independently of the arrangement of the stent frame; wherein, in both of the delivery and deployed positions the second end is distal to the first end; and
a tether secured to the wrap; wherein the wrap is configured so that the wrap can be actuated by tensioning the tether; further wherein the tether can be selectively disconnected from the wrap and the stented prosthetic heart valve is configured such that the wrap remains in the deployed position after the tether is disconnected.

US Pat. No. 10,888,419

CONTINUOUSLY ADJUSTABLE CUTTING TOOL FOR PREPARING VALVE LEAFLET

Terumo Cardiovascular Sys...

1. A device for preparing leaflets for cardiovascular valve reconstruction, comprising:a plurality of blade segments forming a closed periphery for penetrating a membrane to cut a leaflet, wherein the blade segments are circumferentially slidable over one another;
radially-slidable links slidably attached to respective blade segments; and
an adjustment disc coupled to the links, wherein rotation of the adjustment disc varies a radial position of the links which modifies an overlapping of the blade segments, wherein the modifying of the overlapping of the blade segments allows selection of a corresponding size of the closed periphery.

US Pat. No. 10,888,418

PASSIVE MIDDLE EAR PROSTHESIS

MED-EL Elektromedizinisch...

1. A middle ear prosthesis made of a deformable material and comprising:a planar head end with a central portion and a pair of wings extending laterally outward from the central portion, the head end configured to engage with a tympanic membrane of a patient; and
an opposing pair of U-shaped stapes engagement legs coupled to opposing sides of the central portion and extending downwardly from the central portion, wherein the engagement legs are configured to have an adjustable length for engagement with the stapes in the middle ear of the patient;
wherein the head end and the engagement legs are configured to transmit vibrations from the tympanic membrane to the stapes for perception as sound by the patient.

US Pat. No. 10,888,417

IRIS-LENS DIAPHRAGM

1. Iris-lens diaphragm made of elastic material comprising a colored ring having peripheral support elements extending from an edge of the colored ring, the peripheral support elements are adapted for one-point contact and are capable of bending in the plane of the colored ring, wherein the peripheral support elements are arc-shaped and define an open end with a portion of the edge of the colored ring, wherein a thickness of the peripheral support elements exceeds a thickness of the colored ring.

US Pat. No. 10,888,415

TENDON REPAIR IMPLANT AND METHOD OF IMPLANTATION

ROTATION MEDICAL, INC., ...

1. A tendon repair implant comprising:a sheet-like structure including a bioinductive first component configured to encourage tissue in-growth and having a first initial tensile modulus in the range of 5 megapascals (MPa) to 50 MPa, a second component having a second initial tensile modulus, the second tensile modulus greater than the first initial tensile modulus, and a third component having a third initial tensile modulus;
wherein the sheet-like structure conforms to the surface of the tendon and is configured to have an initial load share representing 50% or more of the load of the tendon when affixed to the tendon.

US Pat. No. 10,888,414

AORTIC DISSECTION IMPLANT

inQB8 Medical Technologie...

1. An aortic dissection system for treating a dissection within an aorta of a patient, the aortic dissection system comprising:an aortic dissection implant comprising:
an expandable support structure having a proximal end and a distal end, the expandable support structure sized and configured to be positioned within an ascending portion of the aorta and sized and configured to extend to within a descending portion of the aorta and apply radial force to the descending portion of the aorta when expanded;
at least one layer provided over the expandable support structure comprising an atraumatic outer surface configured to engage an inner wall of the aorta adjacent a false lumen associated with the dissection; and
an expandable interface structure at the distal end of the expandable support structure having a cross-sectional dimension larger than a cross-section dimension of the expandable support structure when both are expanded, the expandable interface structure comprising a metallic frame having a trilobe shape comprising three lobes sized and configured to expand within a corresponding left coronary sinus, a right coronary sinus and a non-coronary sinus, respectively, wherein the trilobe shape is configured to extend from within the left and right coronary sinus distal of a left and right coronary ostia, respectively, and from within the non-coronary sinus, proximally to a sinotubular junction to apply radial force to the left, right and non-coronary sinuses and the sinotubular junction when the expandable interface structure is expanded; wherein the at least one layer extends over the expandable support structure and the expandable interface structure, and wherein the at least one layer comprises a porous section and a non-porous section; and
a delivery system configured to be inserted percutaneously into the patient and advanced into the patient's aorta, the delivery system comprising an outer sheath configured to receive the aortic dissection implant therein in a compressed configuration.

US Pat. No. 10,888,413

MULTI-COMPONENT STENT-GRAFT SYSTEM FOR IMPLANTATION IN A BLOOD VESSEL WITH MULTIPLE BRANCHES

ENDOSPAN LTD., Herzilyia...

1. Apparatus comprising a multi-component stent-graft system, which comprises:a first stent-graft, which is configured to assume radially-expanded and radially-compressed states;
a second stent-graft, which is configured to assume radially-expanded and radially-compressed states; and
a delivery tool, which comprises:
an outer tube, in which the first and the second stent-grafts are initially positioned in their radially-compressed states without being fixed to each other, at respective axial sites within the outer tube such that at least one end of the first stent-graft is within a distance of a distal end of the outer tube, which distance equals the sum of 2 cm and an axial length of the first stent-graft; and
an inner longitudinal member, which (a) is initially positioned such that first and second portions thereof are within the first and the second stent-grafts, respectively, and (b) is shaped so as to define a stopper element, which is:
configured and initially positioned to prevent movement of the first stent-graft in a proximal direction away from the distal end of the outer tube, and
configured to be withdrawable in the proximal direction through the second stent-graft, and after being thus withdrawn, to prevent movement of the second stent-graft in the proximal direction.

US Pat. No. 10,888,412

STENT-GRAFT FOR ANASTOMOSIS

Bipore Medical Devices, I...

1. An anastomosis device comprising:(a) an anchor comprising:
(i) an elongate and curved base comprising:
first and second opposed ends defining a longitudinal axis therein between and curved sides disposed downwardly from the longitudinal axis of the base;
an opening disposed between the first and second opposed ends, the opening being defined by an orifice wall boundary, the orifice wall boundary having first and second generally opposed or displaced orifice wall portions;
(ii) a hook member securably disposed to the curved base proximal to the first generally opposed or displaced orifice wall portion;
(iii) an elongate curved riser comprising:
first and second opposed ends defining a longitudinal axis therein between, the first opposed end of the riser being disposed to the base proximal to the second generally opposed or displaced orifice wall portion; and
first and second opposed curved sides disposed downwardly from the longitudinal axis of the riser, the first and second opposed curved sides each having a terminal anchoring point; and
(b) a tubular and hollow graft secured to the anchor at the hook member and at the terminal anchoring points of the riser.

US Pat. No. 10,888,411

INTRAVASCULAR STENT AND MANUFACTURING METHOD THEREOF

SUZHOU INNOMED MEDICAL DE...

1. An intravascular stent, woven by one to twelve wires and is in a tubular structure, wherein, at least one of the one to twelve wires is a radiopaque wire, wherein, the one to twelve wires have an even number of ends, and the ends of the one to twelve wires are aligned and jointed together with each other, and wherein, the ends of the one to twelve wires all have cutting portions, and the cutting portions of two ends that are aligned and jointed together match each other to form a joint portion with a diameter identical to that of the wire,wherein the cutting portion of the ends is a semi-cylinder, the cutting portion includes a top end surface, a bottom end surface, and a side wall surface, the two side wall surfaces of the two cutting portions that are aligned and jointed together are abutted against each other, and the two top end surfaces are respectively abutted against the corresponding bottom end surfaces, and the two side wall surfaces have a matching concave-convex structure.

US Pat. No. 10,888,410

STENT AND SLEEVE DEPLOYMENT

BOSTON SCIENTIFIC SCIMED,...

1. A delivery system for delivering an implant to a body lumen, the system comprising:an outer tubular member defining a lumen and having a proximal end region and a distal end region;
an inner tubular member defining a lumen and having a proximal end region and a distal end region, the inner tubular member slidably disposed within the lumen of the outer tubular member and having at least one opening positioned in a side wall adjacent to the distal end region, the at least one opening extending from an outer surface to an inner surface of the inner tubular member;
an expandable implant disposed about the outer surface of the inner tubular member adjacent the distal end region of the inner tubular member, the implant comprising at least a first rigid portion and a first flexible portion, the first flexible portion including a proximal end region, a distal end region, and a length extending therebetween; and
a thread including a distal portion wrapped around an outer surface of the first flexible portion of the implant a plurality of times with the distal portion of the thread wrapped along the length of the first flexible portion of the implant, the thread configured to maintain the first flexible portion in a collapsed configuration;
wherein the distal end region of the outer tubular member is disposed over the first rigid portion of the implant and is configured to maintain the first rigid portion in a radially collapsed configuration.

US Pat. No. 10,888,409

BIOMEDICAL PATCHES WITH ALIGNED FIBERS

WASHINGTON UNIVERSITY, S...

1. A three-dimensional electrospun nanofiber synthetic skin graft for use in repairing tissue for wound care, the three-dimensional electrospun nanofiber synthetic skin graft comprising:a flexible electrospun fiber network, the flexible electrospun fiber network comprising:
a first set of electrospun fibers comprising a first bioresorbable polymer, wherein the first bioresorbable polymer comprises polyglycolic acid; and
a second set of electrospun fibers comprising a second bioresorbable polymer, wherein the second bioresorbable polymer comprises caprolactone,
wherein the first bioresorbable polymer comprises a different composition from the second bioresorbable polymer;
the flexible electrospun fiber network further comprising a surface, wherein the surface comprises a surface pattern with nanoscale features,
wherein a first portion of the flexible electrospun fiber network of a particular size comprises a higher number of fibers than a second portion of the flexible electrospun fiber network of the particular size, wherein the first portion comprising the higher number of fibers comprises a first spatial variation between fibers that is lower than a second spatial variation between fibers in the second portion comprising a lower number of fibers;
wherein the three-dimensional electrospun nanofiber synthetic skin graft is sufficiently flexible to facilitate application of the three-dimensional electrospun nanofiber synthetic skin graft to uneven surfaces of the tissue,
wherein the three-dimensional electrospun nanofiber synthetic skin graft is sufficiently flexible to enable movement of the three-dimensional electrospun nanofiber synthetic skin graft by the tissue, and
wherein the first set of electrospun fibers and the second set of electrospun fibers are configured to degrade after application to the tissue.

US Pat. No. 10,888,408

PACKAGING FOR DRY TISSUE PROSTHETIC HEART VALVE

Medtronic Vascular, Inc.,...

1. A packaged prosthetic heart valve, the packaged prosthetic heart valve comprising:a prosthetic heart valve; and
a container including a first compartment housing the prosthetic heart valve and a second compartment housing a hydrogel; wherein a semi-permeable membrane separates the first and second compartments and the semi-permeable membrane further separates the hydrogel from the first compartment.

US Pat. No. 10,888,407

METHOD FOR FORMING A MULTI-LAYER CONSTRUCT

POLY-MED, INC., Anderson...

1. A method for forming a multilayer construct, the method comprising:a) providing an elastomeric base layer comprising a first synthetic polymer;
b) using an electrospinning technique to apply a first solution comprising the first synthetic polymer to the base layer, to provide a first fibrous layer which is elastomeric and directly adjoins the base layer;
c) using an electrospinning technique to apply a second solution comprising a second synthetic polymer to the first fibrous layer, to provide a second fibrous layer which directly adjoins the first fibrous layer;
wherein the first and second fibrous layers have non-identical properties in terms of average diameter of the fibers contained therein such that the fibers of the first fibrous layer have an average diameter which is greater than an average diameter of the fibers of the second fibrous layer.

US Pat. No. 10,888,406

COMPUTER, COMPUTER-IMPLEMENTED METHOD, COMPUTER PROGRAM, AND FACE-BOW

MEDICOM LLC, Fukui (JP)

1. A virtual articulator data generation device capable of generating virtual articulator data which is data of a virtual articulator, by using images of a face-bow comprising an upper-bow fixedly securable to a cranium of a patient, keeping the relative positional relationship including angle in relation to a predetermined reference surface in the cranium of the patient uniquely determined, and a bite-fork fixedly securable to an lower face of a maxillary dental arch of the patient by coating curable substance, which are precisely mounted on the patient, the virtual articulator data generation device comprising:a reception means for receiving maxillary dental arch image data which is data of a maxillary dental arch image defined as an image of a maxillary dental arch, mandibular dental arch image data which is data of a mandibular dental arch image defined as an image of a mandibular dental arch, upper-part image data which is data of an upper-part image defined as an image representative of the relative positional relationship including angle between the bite-fork and a lower face of the maxillary dental arch, relative position image data which is data of relative position images defined as images, in which the upper-bow and the bite-fork are collectively reflected, and representative of the relative positional relationship including angle between the upper-bow and the bite-fork, and occlusal image data which is data of occlusal images defined as images representative of a bite state of the maxillary dental arch and the mandibular dental arch; a model generation means for generating maxillary dental arch model data which is data of a maxillary dental arch model defined as a three-dimensional model of the maxillary dental arch from the maxillary dental arch image data received from the reception means, as well as generating mandibular dental arch model data which is data of a mandibular dental arch model defined as a three-dimensional model of the mandibular dental arch from the mandibular dental arch image data received from the reception means; a position data generation means for obtaining a relative position of the maxillary dental arch including angle in relation to the reference surface in a living patient, from the upper-part image data, and the relative position image data received from the reception means, generating first position data which is data about a position of the maxillary dental arch model relative to a virtual reference surface which is a phantom reference surface, as well as obtaining a relative position of the mandibular dental arch including angle in relation to the maxillary dental arch from occlusal image data received from the reception means, generating second position data which is data about a position of the mandibular dental arch model relative to the maxillary dental arch model; and a linking means for receiving the maxillary dental arch model data, and the mandibular dental arch model data from the model generation means, as well as receiving the first position data, and the second position data from the position data generation means, and generating the virtual articulator data, so that the relative positional relationship between the maxillary dental arch and the mandibular dental arch relative to the reference surface in the living patient is reproduced in the positional relationship between the maxillary dental arch model and the mandibular dental arch model relative to the virtual reference surface by using the first position data, and the second position data.

US Pat. No. 10,888,405

SONIC VIBRATION TOOTHBRUSH

One Star International Co...

1. A sonic vibration toothbrush, that uses vibration by a sonic wave, comprising:a head extending in an axial direction and having a plurality of bristles implanted at an outer circumference thereof in a direction perpendicular to the axial direction;
a head arm having an inner space to transmit the sonic wave to the head and having a truncated cone shape so that the inner space is narrowed from a bottom to a top, wherein a top portion of the head arm where the inner space is narrowed is coupled to the head;
an accommodating portion having a motor therein and coupled to the bottom of the head arm to transmit a sonic wave generated by a rotating force of the motor to the head arm;
a handle formed in a streamlined shape and having a space for accommodating a battery;
an input unit provided at the accommodating portion in a button form;
a display unit provided at the handle and having at least two lamps; and
a control circuit configured to control the motor according to input information provided from the input unit,
wherein the head includes a head body extending in the axial direction and a plurality of washer rings provided around the head body and head body is inserted into the plurality of washer rings,
wherein the head is partially inserted into the head arm and coupled to the head arm, a portion of the head inserted into the head arm has a greater diameter than a portion of the head not inserted into the head arm, and the portion of the head inserted into the head arm and the portion of the head not inserted into the head arm are connected with a slope,
wherein the plurality of washer rings include at least one washer ring at which the plurality of bristles are implanted and at least one washer ring at which no bristle is implanted,
wherein the input unit includes a first input button, and second and third input buttons located at upper and lower sides based on the first input button, wherein the input unit includes fourth and fifth input buttons located at left and right sides based on the first input button, wherein in the user setting mode, when the fourth input button located at the left side of the first input button or the fifth input button located at the right side of the first input button is operated, the rotating speed of the motor is increased or decreased as much as a second unit rotating speed which is different from the first unit rotating speed,
wherein when the first input button is operated, the sonic vibration toothbrush is powered on so that the motor rotates at a predetermined rotating speed, or an operation mode of the sonic vibration toothbrush is shifted to a user setting mode in which a rotating speed of the motor is set, or the sonic vibration toothbrush is powered off,
wherein in the user setting mode, when the second input button located at the upper side of the first input button is operated, the rotating speed of the motor is increased as much as a first unit rotating speed and set to an increased rotating speed, and when the third input button located at the lower side of the first input button is operated, the rotating speed of the motor is decreased as much as the first unit rotating speed and set to a decreased rotating speed,
wherein, when the sonic vibration toothbrush is powered on and after the rotating speed of the motor is set in the user setting mode, the motor rotates at the set rotating speed, and
wherein the bristles implanted at the head have lengths which are longer as being farther from the head arm and shorter as being closer to the head arm.

US Pat. No. 10,888,404

TEETH FLOSSING WEDGE

1. A wedge-shaped teeth flossing device comprising:a planar body having a first thickness including:
a first planar end;
a second planar end opposed from the first planar end; the first and second planar ends connected by a top edge opposing a bottom edge: the bottom edge comprising a textured surface;
a triangular shaped lead point formed at an intersection of the too edge and the second planar end, the lead point having a first thickness;
the planar body folded on itself such that the lead point extends entirely below the bottom edge of the planar body by forming a crease in the planar body, the crease extending downwardly from the first planar end to the second planar end;
a following point located on the second planar end at an intersection with the crease, the following point having a second thickness, thicker than the first thickness;
a tapered top edge extending between said first planar end and said second planar end;
a cleaning point formed at an intersection of the bottom edge and said second planar end, the cleaning point having a first thickness;
wherein the lead point, cleaning point and following point all comprise textured surfaces; and wherein the first planar end is configured to form a non-textured gripping surface,
an asymmetric groove recessed inward from the bottom edge.

US Pat. No. 10,888,403

INTERDENTAL BRUSH AND CLEANING DEVICE FOR THE SAME

1. An interdental brush comprising:a brush body having a handle and a guide duct, the guide duct defining a distal end, the distal end being distal from the handle;
a flexible positioning element, the positioning element provided at the distal end of the guide duct and being tapered;
an operating element; and
a cleaning device comprising a cleaning body and an elongate connection element defining a proximal and distal end, the cleaning body being disposed on the distal end of the connection element, the connection element being made of a flexible material disposed within the guide duct and wherein a coupling element longitudinally extends from the proximal end of the connection element and is configured to removably couple with a receptacle extending from the operating element;
wherein the cleaning device is displaceable by actuation of the operating element in a reciprocating manner between a retracted position in which the cleaning body is disposed within the guide duct, and a deployed position in which the cleaning body protrudes outwardly from the distal end of the guide duct;
wherein the positioning element is engageable with an approximal space between the two teeth, such that the cleaning body is configured to be deployed into the approximal space while in the deployed position;
wherein the connection element is configured to be interchangeably and removably connected to the operating element;
wherein the interdental brush comprises a circumferential outer surface; the circumferential outer surface comprising a longitudinally extending slot, the slot arranged and dimensioned such that a bent portion of the connection element can deflect outward through the slot to outside the guide duct when the connection element is bent due to certain compression forces being applied to the cleaning body.

US Pat. No. 10,888,402

MOBILE LINKED IMPLANT DIAGNOSIS SYSTEM

MEGAGEN IMPLANT CO., LTD....

1. A mobile linked implant diagnosis system comprising:an implant diagnosis apparatus acquiring synthetic three-dimensional (3D) image data about a mouth area of a target patient and generating implant surgery planning data, in which virtual implant data is overlapped on the synthetic 3D image data, based on the synthetic 3D image data, wherein the implant diagnosis apparatus comprises:
a first image information acquirement apparatus acquiring first 3D image data about the mouth area of the target patient;
a second image information acquirement apparatus acquiring second 3D image data by scanning plaster patterns of teeth of the target patient, wherein the plaster patterns of teeth are provided with a matching reference marker for matching the first 3D image data and the second 3D image data, and wherein the matching reference marker is provided plurally, and the plurality of matching reference markers are arranged spaced apart from one another; and
a data processing apparatus receiving and matching the first 3D image data and the second 3D image data and generating the synthetic 3D image data, and generating surgery planning data based on the synthetic 3D image data, wherein the data processing apparatus comprises:
an input unit receiving information from a user;
an operation unit generating the synthetic 3D image data, electrically connected to the input unit, and correcting the synthetic 3D image data based on the information input from the user; and
a display unit electrically connected to the operation unit and visually displaying the synthetic 3D image data,
wherein the data processing apparatus generates the synthetic 3D image data by performing a pre-matching operation of pre-matching the first 3D image data and the second 3D image data based on a coordinate of the matching reference marker of the second 3D image data and then performing a precise matching operation of precisely matching the second 3D image data to the first 3D image data in the pre-matched synthetic 3D image data,
wherein, in the precise matching operation, the operation unit:
sections a display area of the display unit into a plurality of divided zones,
arranges different plane images of the pre-matched synthetic 3D image data in the plurality of divided zones, and
receives an input of a state of matching, in which the user precisely matches the second 3D image data to the first 3D image data in each divided zone through the input unit;
a server apparatus connected to the implant diagnosis apparatus in a wired or wireless manner, and receiving information of interest that is a subset of the implant surgery planning data generated in the implant diagnosis apparatus and storing the information of interest; and
a mobile device connected to the server apparatus in a wired or wireless manner, and receiving only the information of interest from the server apparatus and displaying the information of interest,
wherein the information of interest comprises partial 3D image data of the implant surgery planning data, the partial 3D image data being data about a preset area around the virtual implant.

US Pat. No. 10,888,401

VIEWFINDER WITH REAL-TIME TRACKING FOR INTRAORAL SCANNING

Align Technology, Inc., ...

1. A method for guiding scanning of an intraoral cavity of a patient, the method comprising:capturing a first viewfinder image of a first portion of the intraoral cavity of the patient, the first viewfinder image including a field of view of an intraoral scanner;
capturing first scan data comprising first topography data of the first portion of the intraoral cavity and corresponding to the first viewfinder image by measuring one or more characteristics of returning light, the returning light having been reflected off surfaces within the intraoral cavity;
comparing at least one of a) the first scan data to previously captured scan data or b) the first viewfinder image to one or more previously captured viewfinder images;
determining, based on a result of the comparing, that a criterion is not satisfied;
displaying the first viewfinder image; and
displaying one or more visual indicators, the one or more visual indicators comprising a warning indicator indicating a potential problem associated with the criterion not being satisfied.

US Pat. No. 10,888,400

METHODS AND APPARATUSES FOR FORMING A THREE-DIMENSIONAL VOLUMETRIC MODEL OF A SUBJECT'S TEETH

Align Technology, Inc., ...

1. A method comprising:receiving scan data of a patient's dentition comprising a first set of two-dimensional (2D) images taken with a hand-held intraoral scanner operating in a first mode;
generating a three-dimensional (3D) model of one or more teeth using the first set of 2D images;
receiving scan data of the patient's dentition comprising a plurality of 2D near-infrared (near-IR) images of the one or more teeth taken with the hand-held intraoral scanner operating in a second mode;
receiving, based on a user selection, one or more 2D near-IR images including an internal feature from the plurality of 2D near-IR images;
correlating the one or more 2D near-IR images to the 3D model to associate a location of the one or more 2D near-IR images with a corresponding location in the 3D model; and
displaying the 3D model showing a section through the 3D model with the one or more 2D near-IR images included on the section, showing internal structures including the internal feature.

US Pat. No. 10,888,399

AUGMENTED REALITY ENHANCEMENTS FOR DENTAL PRACTITIONERS

Align Technology, Inc., ...

1. A system comprising:a memory device; and
a processing device operatively coupled to the memory device, the processing device to:
receive an image of a dental arch, the image having been generated by an image capture device associated with an augmented reality (AR) display;
determine an intraoral procedure to be performed on a tooth of the dental arch;
detect a first area of interest in the image of the dental arch, wherein the first area of interest is associated with the intraoral procedure;
provide a visual overlay for output on the AR display identifying the first area of interest;
identify a change to the first area of interest during the intraoral procedure based on a comparison of first image data received from the image capture device to previous image data received from the image capture device; and
determine a first update to the visual overlay based on the change to the first area of interest.

US Pat. No. 10,888,398

CERAMIC IMPLANT

Z-SYSTEMS AG, Oensingen ...

1. A method for producing a dental implant, wherein the dental implant has a ceramic endosseous surface area of an endosseous portion, comprising the steps of:in a first step, providing the implant having an intended shape, which includes the ceramic endosseous surface area, said ceramic endosseous surface area comprising a thread having a first region and a second region, wherein said first region comprises crests and upper flank areas of the thread and the second region comprises a thread root, which is disposed between said upper flank areas of said thread and,
in a second step, modifying said ceramic endosseous surface area in order to obtain a roughening or porous structure for promoting osseointegration,
wherein in the second step, the implant surface is modified in said first region of the thread to a first extent, whereas said second region of the thread is not modified, or is modified to a second extent, said second extent being less than said first extent.

US Pat. No. 10,888,397

METHOD AND SYSTEM FOR DENTAL BOUNDARY DETERMINATION

Oxilio Ltd, Larnaca (CY)...

1. A method of determining a boundary between a plurality of teeth and gingiva of an archform, the method executable by an electronic device, the method comprising:receiving a three-dimensional (3D) digital model of the archform comprising a representation of the gingiva and the plurality of teeth of the archform;
defining, for each tooth of the plurality of teeth of the archform, a plurality of curves, wherein each curve of the plurality of curves crosses the boundary between the plurality of teeth and the gingiva;
inputting, to a machine learning algorithm (MLA), the plurality of curves and a plurality of points of each curve of the plurality of curves, wherein the MLA was trained using labeled training data points, and wherein each labeled training data point comprises a location on a corresponding curve and a label indicating whether the location on the corresponding curve corresponds to a boundary between teeth and gingiva on the corresponding curve;
outputting, by the MLA and for each point of the plurality of points, a predicted likelihood parameter indicating whether each point of the plurality of points corresponds to the boundary between the plurality of teeth and the gingiva of the archform; and
selecting, for each curve of the plurality of curves, using a smoothing function and the predicted likelihood parameter, a single point, of the plurality of points, on a respective curve as a boundary point corresponding to the boundary between the plurality of teeth and the gingiva of the archform.

US Pat. No. 10,888,396

INTRAORAL APPLIANCES WITH PROXIMITY AND CONTACT SENSING

Align Technology, Inc., ...

1. A device for monitoring usage of an intraoral appliance, the device comprising:one or more deflectable structures formed with or coupled to the intraoral appliance, wherein the one or more deflectable structures are shaped to be deflected when the intraoral appliance is worn on a patient's teeth; and
a sensor configured to generate sensor data indicative of deflection of the one or more deflectable structures; and
a processor operably coupled to the sensor and configured to process the sensor data so as to determine whether the intraoral appliance is being worn on a patient's teeth.

US Pat. No. 10,888,395

MOLD AND ALIGNER WITH CUT LINE MARKINGS

Align Technology, Inc., ...

1. A method comprising:determining, by a processing device, a cut line for a shell that is to be formed over a mold of a dental arch of a patient, wherein the cut line is customized for the dental arch of the patient;
determining, by the processing device, one more markings for the shell that will mark the cut line;
determining, by the processing device, one or more features to add to the mold over which the shell will be formed that will cause the shell to have the one or more markings; and
generating, by the processing device, a digital model of the mold, the digital model comprising the one or more features, wherein the digital model is usable to manufacture the mold having the one or more features.

US Pat. No. 10,888,394

APPARATUSES TO PHYSICALLY COUPLE TRANSPONDER TO OBJECTS, SUCH AS SURGICAL OBJECTS, AND METHODS OF USING SAME

COVIDIEN LP, Mansfield, ...

1. An apparatus to physically couple one or more transponders to a surgical object used in a surgical environment, the apparatus comprising:at least one transponder that wirelessly receives and returns signals; and
a housing including:
a body configured to retain the at least one transponder at least partially therein, the body defining a bottom, a first end portion and a second end portion;
a first leg depending from the bottom of the body near the first end portion thereof, the first leg defining a bottom spaced a distance from the bottom of the body; and
a second leg depending from the bottom of the body near the second end portion thereof, the first leg and the second leg being spaced apart from one another, the second leg defining a bottom spaced a distance from the bottom of the body,
wherein the bottom of the first leg and the bottom of the second leg each contact the surgical object to space the bottom of the body of the housing away from the surgical object a distance sufficient to prevent signal loss of the at least one transponder caused by the surgical object,
at least a first clamp including:
a first fastener; and
a first channel member, the first channel member having a first base and a first pair of side portions that extend from the first base and which are opposed to one another across a width of the first channel member to form a first channel therebetween, the width of the first channel sized to receive at least a first portion of the surgical object therein, wherein the first fastener adjustably engages with the first channel member and with the first leg of the housing to clamp the first portion of the surgical object in the first channel of the first channel member,
a second clamp including:
a second fastener; and
a second channel member, the second channel member having a second base and a second pair of side portions that extend from the second base and which are opposed to one another across a width of the second channel member to form a second channel therebetween, the width of the second channel sized to receive at least a second portion of the surgical object therein, wherein the second fastener adjustably engages with the second channel member and the second leg of the housing to clamp the second portion of the surgical object in the second channel of the second channel member,
wherein the first leg of the housing defines:
at least a first cavity that receives at least a portion of the first pair of side portions of the first channel member; and
a first passageway that receives the first fastener and opens at least in part into the first cavity to permit the first fastener to extend at least in part into the first cavity and adjustably engage with the first channel member,
wherein the body of the housing defines a second passageway that receives the at least one transponder,
wherein the second leg of the housing defines:
a second cavity that receives at least a portion of the second pair of side portions of the second channel member; and
a third passageway that receives the second fastener and opens at least in part into the second cavity to permit the second fastener to extend at least in part into the second cavity and adjustably engage with the second channel member,
wherein the first passageway extends in a first direction, the second passageway extends in a second direction, and the third passageway extends in a third direction, the third direction parallel to the first direction, the second direction non-parallel with respect to the first and the third directions, and
wherein the first fastener and the second fastener respectively have an elongated shaft that has a first diameter and a head that has a second diameter that is greater than the first diameter, and the first passageway and the third passageway respectively have an outer portion that has a third diameter that is greater than the second diameter and an inner portion that has a fourth diameter that is greater than the first diameter and less than the second diameter.

US Pat. No. 10,888,393

CLEANING DEVICE AND METHOD FOR FLUID TRANSFER CONNECTOR

NeoMed, Inc., Woodstock,...

1. A cleaning device for cleaning a connector, the connector comprising a stem and a lumen extending therethrough, the cleaning device comprising:a handle defining a longitudinal central axis;
at least one brush mounted to the handle; and
a plunger coupled to the handle and generally extending along the longitudinal central axis, the plunger defining a first end and second end, the plunger comprising an actuating end at the first end such that the plunger can move along the longitudinal central axis.

US Pat. No. 10,888,392

BUSHING, SUPPORT ARM, AND SUPPORT SYSTEM FOR A MEDICAL TECHNICAL STAND APPARATUS

1. A device for a stand apparatus for arrangement in an operating theater, comprising:a bushing having a bottom surface, the bushing including:
a coupling part configured to be rotatably coupled to a spindle of the stand apparatus, the coupling part including an upper annular segment and a lower annular segment in spaced relationship and a rotation axis centrally disposed with respect to the upper and lower annular segments, the lower annular segment including a first surface and a second surface;
a threaded hole in the lower annular segment structured to receive a braking screw;
a recess in the first surface of the lower annular segment structured to lock a slip ring;
a mounting segment integral with the coupling part and configured to be coupled to a support arm of the stand apparatus; and
a receptacle extending from the bottom surface of the bushing structured to receive a locking bolt.

US Pat. No. 10,888,391

OPTICAL FORCE SENSING ASSEMBLY FOR AN ELONGATED MEDICAL DEVICE

Ablacon Inc, Wheat Ridge...

1. A medical optical force sensing assembly configured for use in a distal portion of an intravascular catheter, comprising:a light source configured to define a linear optical light source axis (A);
an optical sensor configured to define a linear optical sensor axis (B) and to face the light source, the optical sensor being arranged at a distance (d0, d1) from the light source along the optical axis (B);
a mounting assembly for the optical sensor and the light source comprising a compressible elastic element configured to permit relative movement between the light source and the optical sensor at least in directions X, Y, Z of a Cartesian coordinate system, wherein the direction Z is parallel to the optical light source axis and to the optical sensor axis (B) at least when the distal portion of the intravascular catheter is in an initial undeformed state and not subjected to a force (F) operating thereon, and wherein the X and Y directions are perpendicular to one another and are also perpendicular to the Z direction;
and further wherein the optical sensor comprises a camera module having an array of n pixels, where the n pixels are configured to receive light from the light source, and where a size of the pixel array illuminated by the light source is proportional to the force (F) as the force (F) is applied in the Z direction to the compressible elastic member through the distal portion of the intravascular catheter.

US Pat. No. 10,888,390

STERILE DRAPE

SONY OLYMPUS MEDICAL SOLU...

1. A sterile drape comprising:a bag shaped body configured to cover a medical observation apparatus to keep a sterile site from the medical observation apparatus, and
an attaching part disposed on the bag shaped body in a position near an input part of the medical observation apparatus in use, the input part being provided on a grip of the medical observation apparatus, and the input part being a switch configured to receive a user input of an instruction to the medical observation apparatus, wherein
the attaching part is configured to be fixed near the input part to fix the bag shaped body to the grip.

US Pat. No. 10,888,389

SYSTEMS AND METHODS FOR ARBITRARY VIEWPOINT ROBOTIC MANIPULATION AND ROBOTIC SURGICAL ASSISTANCE

Duke University, Durham,...

1. A system comprising:a robotic tool interface configured to control a robotic tool;
at least one controller configured to:
receive an image dataset from an imaging system with an imaging perspective of an actual environment within which the robotic tool is positioned;
generate a virtual environment of the actual environment based on the image dataset;
control display of the virtual environment including a virtual tool controllable by a user for use to control the robotic tool within the actual environment;
receive user input for controlling the virtual tool to control the robotic tool;
output a command, based on the received input, to control movement of the robotic tool via the robotic tool interface;
receive user input for altering a virtual perspective view of display of the virtual environment to another virtual perspective view that does not coincide with the imaging perspective;
alter the display of the virtual environment from one of the one or more virtual perspective views to another virtual perspective view;
provide simultaneous display of the actual environment from the imaging perspective and of the virtual environment from the other virtual perspective view; and
maintain orientation of display of the virtual tool with respect to the user during display of the other virtual perspective view of the virtual environment.

US Pat. No. 10,888,388

MEDICAL-MANIPULATOR ROTATION MECHANISM

OLYMPUS CORPORATION, Tok...

1. A medical-manipulator rotation mechanism comprising:a cylindrical rotator fixed to a treatment part at a distal end of the rotator, the rotator being supported so as to be rotatable about a longitudinal axis;
an elongated power-transmitting member having first and second ends and a portion wound around the rotator; and
a folding part that bends the first and second ends of the power-transmitting member in a tangential direction from the portion wound around the rotator and extends each of the first and second ends from the rotator toward a proximal-end side.

US Pat. No. 10,888,387

ARTICULATION MECHANISMS FOR SURGICAL INSTRUMENTS SUCH AS FOR USE IN ROBOTIC SURGICAL SYSTEMS

Covidien LP, Mansfield, ...

1. An articulation assembly for a surgical instrument, comprising:first, second, third, and fourth lead screw assemblies, each lead screw assembly including a lead screw and a collar operably engaged about the lead screw such that rotation of the lead screw translates the collar about the lead screw,
first, second, third and fourth articulation cables operably coupled to the collars of the first, second, third, and fourth lead screw assemblies, respectively, such that proximal movement of one of the collars about the respective lead screw tensions the corresponding articulation cable and such that distal movement of one of the collars about the respective lead screw de-tensions the corresponding articulation cable;
first, second, third and fourth proximal gear assemblies coupled to the lead screws of the first, second, third, and fourth lead screw assemblies, respectively;
a first coupling gear coupling the first and third proximal gear assemblies with one another to maintain a pre-tension on the first and third articulation cables; and
a second coupling gear coupling the second and fourth proximal gear assemblies with one another to maintain a pre-tension on the second and fourth articulation cables.

US Pat. No. 10,888,386

SURGICAL ROBOTICS SYSTEMS WITH IMPROVED ROBOTIC ARMS

Auris Health, Inc., Redw...

1. A system, comprising:a table;
a table support below the table;
an arm support coupled to at least one of the table or the table support;
a first robotic arm coupled to the arm support, wherein the first robotic arm comprises a proximal portion and a distal portion and at least four powered joints between the proximal portion and the distal portion, wherein each of the joints is capable of being actuated independently of the other joints, wherein the first robotic arm comprises an instrument drive mechanism fixedly attached to the first robotic arm;
a surgical instrument comprising:
an elongated shaft;
a base configured to removably attach to the instrument drive mechanism of the first robotic arm to attach the surgical instrument to the first robotic arm,
wherein the base comprises an attachment interface configured to attach to a proximal face of the instrument drive mechanism,
wherein the elongated shaft is coupled to the base and configured to translate through a central passage extending through the instrument drive mechanism and the base, and
wherein the base of the surgical instrument comprises an insertion mechanism configured to provide translation of the elongated shaft relative to the base along an insertion axis such that the elongated shaft can be inserted through the base while a position of the base remains stationary, wherein the insertion mechanism comprises at least one pulley positioned within the base that is engaged with a cable connected to the elongated shaft; and
a second robotic arm coupled to the arm support.

US Pat. No. 10,888,385

CALIBRATION DEVICE AND CALIBRATION METHOD FOR SURGICAL INSTRUMENT

POINT ROBOTICS MEDTECH IN...

1. A calibration device for a computer-assisted surgical instrument, comprising:a rigid body;
a plurality of stabilization members; and
a plurality of references structurally or mechanically complementary to the stabilization members and disposed on opposite sides of a manipulator of the instrument,
wherein kinematic state of the manipulator is defaulted when the calibration device is connected to the instrument by the stabilization members passing through the rigid body and removably attaching to the references.