US Pat. No. 10,556,097

DEVICES FOR TREATING SKIN USING TREATMENT MATERIALS LOCATED ALONG A TIP

Edge Systems LLC, Long B...

1. A method for treating a skin surface, comprising:delivering fluid to a tip of a handpiece assembly, wherein the handpiece assembly comprises at least one delivery conduit through which the fluid is configured to be delivered;
wherein the at least one delivery conduit is in fluid communication with a fluid source; and
providing at least one time-release material to the skin surface by delivering fluid to the tip, the at least one time-release material being configured to have an effect on the skin surface after a time period after providing the at least one time-release material to the skin surface;
wherein the at least one time-release material is positioned on the tip, the fluid at least partially dissolving the at least one time-release material when the fluid is delivered to the tip.

US Pat. No. 10,556,096

DEVICES AND METHODS FOR SKIN TREATMENT

Edge Systems LLC, Long B...

1. A system for treating skin of a human, the system comprising:a handpiece assembly comprising a tip and a main body portion;
a waste canister;
at least one fluid delivery passage placing the tip in fluid communication with a fluid source; and
at least one suction passage placing the waste canister in fluid communication with the tip;
wherein the tip comprises a peripheral lip;
wherein when the tip is placed against a skin surface, a suction from the at least one suction passage draws at least a portion of a fluid through the at least one fluid delivery passage to the tip, and waste materials are transferred from the tip to the waste canister through the at least one suction passage;
wherein the waste canister is configured to be physically attached to the handpiece assembly, the waste canister being configured to removably attach to the main body portion; and
wherein the waste canister is configured to form a unitary structure with the main body portion when attached thereto.

US Pat. No. 10,556,095

GOOGLE BREATHING SYSTEM

1. A disposable apparatus attachable to a nose of a wearer and useable with an external magnetic element positioned adjacent to the nose of the wearer, the disposable apparatus comprising:a flexible base layer including a first surface and an opposing second surface;
an adhesive disposed on the first surface of the flexible base layer and capable of producing an adhesive force between the flexible base layer and the wearer for attaching the flexible base layer to the nose of the wearer, the adhesive being capable of increasing the adhesive force after the flexible base layer has been attached to the nose of the wearer; and
a metallic element coupled to the second surface of the base layer and being magnetically interactable with the magnetic element when the magnetic element is positioned adjacent the nose of the wearer and the flexible base layer is attached to the nose of the wearer, the metallic element including a metallic disc having an arcuate surface extending away from the second surface of the base layer, the magnetic interaction between the metallic element and the magnetic element imparting a dilating force on the nose of the wearer causing the nose of the wearer to dilate, the metallic element being sized to reside adjacent only one of the nostrils on the nose of the wearer when the disposable apparatus is attached to the nose of the wearer;
the disposable apparatus being sized and shaped to be translatable relative to the magnetic element while the metallic element is magnetically coupled to the magnetic element;
the disposable apparatus being capable of residing on the nose of the wearer in an OFF state wherein no dilating force is imparted on the wearer by the disposable apparatus.

US Pat. No. 10,556,094

INTERVENTIONAL TOOL DELIVERY DEVICES, SYSTEMS AND METHODS

Radux Devices, LLC, Omah...

1. A method of delivering an interventional tool, comprising:positioning a catheter through an access point in a side wall of an anatomical vessel of a patient in the direction of an insertion axis, the catheter having a distal end, a proximal end, and at least one lumen extending between the distal end and the proximal end, the catheter configured to receive an interventional tool;
attaching a support sheath to the catheter, the support sheath comprising a first end having a connector configured to releasably connect with the proximal end of the catheter and a second end comprising a port configured to receive the interventional tool, the support sheath having a distal portion proximate the first end and a proximal portion proximate the second end;
retaining the support sheath in a selected curved configuration by engaging the support sheath with one or more retention features of a retainer, the retainer configured to retain the support sheath in two or more configurations, the distal portion fixed in different angled orientations relative to the proximal end when attached to the catheter in each of the two or more configurations; and
advancing the interventional tool by a practitioner along an advancement direction offset from the insertion axis to deliver the interventional tool within an internal access path through the support sheath, catheter, and into the anatomical vessel.

US Pat. No. 10,556,093

MEDICAL DEVICES, DRESSINGS, AND METHODS FOR CLOSING OPENINGS IN TISSUE

Confluence, LLC, Laguna ...

1. A noninvasive cinching device, comprising:a compliant adhesive pad defining a catheter-receiving opening;
a flexible elongate tensioner configured to be coupled to the compliant adhesive pad such that a tensioned section of the flexible elongate tensioner is spaced apart from and extends about both the catheter-receiving opening and a catheter extending through the catheter-receiving opening;
a tensioner retainer configured to hold the flexible elongate tensioner; and
a plurality of spaced apart holders coupled to the compliant adhesive pad, wherein the holders are arranged in a discrete fashion and configured to move radially inward toward the catheter such that the compliant adhesive pad applies sufficient radially inward shear pressure to a subject's skin to substantially decrease a radial distance between a perimeter of the catheter-receiving opening and the catheter to press the subject's tissue toward the catheter when the catheter is positioned in the catheter-receiving opening, a region of the compliant adhesive pad surrounding the catheter-receiving opening lays flat along subject's skin, and the flexible elongate tensioner is held by the holders, thereby inhibiting pericatheter leakage.

US Pat. No. 10,556,091

THREADED, LOCKING HANDLE MECHANISM FOR ATTACHING TO SHAFT

St. Jude Medical, Cardiol...

1. A strain relief, comprising:a strain relief projection extending around a complete inner circumference of the strain relief; and
a nut comprising:
a nut thread;
a nut recess extending around a complete outer circumference of the nut;
a through-hole; and
a plurality of ratchets,
wherein the strain relief projection is configured to couple to the nut recess and to secure the nut to the strain relief.

US Pat. No. 10,556,090

RESOURCE INFORMATION KEY FOR AN INSERTABLE MEDICAL DEVICE

C. R. Bard, Inc., Murray...

1. A method of making a medical device, comprising:producing a peripherally inserted central catheter access line comprising:
an internal portion designed for intravascular insertion into a patient; and
an external portion designed to remain outside of the patient; and
imparting a visible internet-based resource information key at a predetermined key location on the external portion, the visible internet-based resource information key designed to be viewed following insertion of the internal portion into the patient to facilitate acquisition of information about the peripherally inserted central catheter access line by accessing the internet and entering the visible internet-based resource information key.

US Pat. No. 10,556,089

FLEX CIRCUIT RIBBON BASED ELONGATED MEMBERS AND ATTACHMENTS

Heraeus Medical Component...

1. An apparatus, comprising:an elongated inner portion;
an elongated outer portion;
a flex circuit ribbon, comprising at least one conductor embedded in a flexible insulator, the flex circuit ribbon situated between the inner portion and the outer portion, wherein the inner portion and the outer portion are bonded together between wound portions of the flex circuit ribbon;
an electrical contact included in or connected to the at least one conductor of the flex circuit ribbon; and
a connector configured to connect an end-user attachable or detachable elongated portion to the flex circuit ribbon, the connector comprising a first plurality of electrical connectors configured to be respectively individually coupled to the conductors of the flex circuit ribbon.

US Pat. No. 10,556,088

SAFE URINARY CATHETER AND MANUFACTURING METHOD

SAFE MEDICAL DESIGN, INC....

1. A method of positioning a urinary catheter in a patient, the method comprising:advancing a distal end of the urinary catheter through the patient's urethra;
introducing inflation fluid into the urinary catheter to inflate a retention balloon at or near the distal end of the urinary catheter, wherein the retention balloon has a preformed balloon shape and a first threshold opening pressure;
observing at least partial inflation of a pilot balloon at or near a proximal end of the urinary catheter, located outside the patient, wherein the pilot balloon has a tubular shape and a second threshold opening pressure that is higher than the first threshold opening pressure;
waiting for a predefined amount of time of less than ten seconds for the pilot balloon to deflate;
if the pilot balloon deflates during the predefined amount of time:
determining, based on deflation of the pilot balloon during the predefined amount of time, that a false inflation of the pilot balloon has occurred and the retention balloon is located in the patient's urinary bladder; and
leaving the urinary catheter in place within the patient; or
if the pilot balloon does not deflate during the predefined amount of time:
removing the inflation fluid from the urinary catheter; and
repositioning or removing the urinary catheter.

US Pat. No. 10,556,087

ENHANCING MUSIC FOR REPETITIVE MOTION ACTIVITIES

MEDRHYTHMS, INC., Portla...

1. A method of providing repetitive motion therapy, the method being implemented on a computer system having a processor configured by computer-executable code to perform the method, comprising:providing, at the processor, access to one or more pieces of audio content;
selecting, using the processor, a piece of audio content for delivery to a patient;
performing, by the processor, an analysis on the selected audio content,
wherein the analysis performed by the processor includes identifying audio features of the selected audio content, and
extracting, based on the analysis, rhythmic and structural features of the selected audio content;
performing, by the processor using the extracted rhythmic and structural features, an entrainment suitability analysis on the selected audio content to identify features among the rhythmic and structural features of the selected audio content that are suitable for augmenting using cues to trigger kinematic motion;
generating, by the processor based on the entrainment suitability analysis, entrainment assistance cues for the selected audio content, the assistance cues including a sound added to one or more of the identified features of the selected audio content;
applying, by the processor, the assistance cues to the identified features of the selected audio content simultaneously with playing the selected audio content and thereby playing the selected audio content augmented with the assistance cues using an audio output device; and
evaluating, by the processor based on biomechanical data of the patient captured using a sensor while playing the selected audio content and the assistance cues, a therapeutic effect of the selected audio content and the assistance cues on the patient,
wherein the selected audio content continues to play when the therapeutic effect meets a therapeutic threshold, and when the therapeutic effect fails to meet the therapeutic threshold repeating one or more of the steps of selecting audio content, performing an entrainment suitability analysis and generating entrainment assistance cues.

US Pat. No. 10,556,086

METHODS OF ADMINISTERING HIGH CONCENTRATIONS OF NITRIC OXIDE

Mallinckrodt Hospital IP ...

1. A method of treating pulmonary hypertension, the method comprising:administering a plurality of pulses of therapeutic gas comprising nitric oxide (NO) to a patient in need thereof for a treatment time of at least 72 hours, wherein at least one pulse:
i. comprises a NO delivery concentration of greater than or equal to 4,600 ppm NO,
ii. is administered at a dosing rate of less than or equal to 83 ?g NO per second,
iii. is administered at a therapeutic gas flow rate of less than or equal to 0.8 L/min,
iv. has a pulse volume of less than or equal to 1 mL, and
v. comprises less than 420 nmol of NO; and
diluting the pulses of therapeutic gas in the patient's trachea and/or lungs to an alveolar concentration less than the delivery concentration.

US Pat. No. 10,556,085

HEAT-MOISTURE EXCHANGER WITH AEROSOL BYPASS

1. A heat-moisture exchanger device for use with a patient ventilator circuit, the heat-moisture exchanger device comprising:a housing comprising a first wall, an opposed second wall and sidewall extending between the first wall and the second wall such that a chamber is defined by the first wall, the second wall and the sidewall, wherein a first conduit is positioned thereon an outer surface of the first wall, wherein a first passageway is defined through the first conduit and the first wall, wherein a second conduit is positioned thereon an outer surface of the second wall, wherein a second passageway is defined through the second conduit and the second wall, and wherein a longitudinal axis of the first conduit and a longitudinal axis of the second conduit are substantially aligned;
a rotatable central element positioned in the chamber of the housing, wherein the rotatable central element comprises a body, wherein a third conduit having a longitudinal axis is positioned thereon the body, wherein the third conduit extends from a first side of the body to a second side of the body, and wherein a third passageway is defined through the third conduit; and
a filter coupled to and rotatable with the rotatable central element,
wherein the rotatable central element is rotatable about and between a first position, in which the longitudinal axis of the third conduit is substantially aligned with the longitudinal axis of the first conduit and the longitudinal axis of the second conduit, and a second position, in which the longitudinal axis of the third conduit is not aligned with the longitudinal axis of the first conduit and is not aligned with the longitudinal axis of the second conduit,
wherein the rotatable central element further comprises a handle extending through the first wall, and wherein the handle is coupled to the body such that rotation of the handle causes the body to rotate relative to the housing,
wherein rotation of the handle causes the rotatable central element to rotate about and between the first position and the second position,
wherein the rotatable central element further comprises a plurality of gears, wherein a first gear of the plurality of gears is coupled to the handle and a second gear of the plurality of gears is coupled to the body, and wherein teeth defined in the first gear interlock with teeth defined in the second gear such that rotation of the first gear causes corresponding rotation of the second gear.

US Pat. No. 10,556,084

MASK ASSEMBLY

ResMed Pty Ltd, Bella Vi...

1. A mask assembly to provide pressurized air to nasal passages of a patient, comprising:a nasal assembly shaped to seal around the nasal passages and above a mouth of the patient and deliver pressurized air to the nasal passages, a portion of the nasal assembly that is shaped to seal around the nasal passages of the patient being formed of silicone, the nasal assembly defining a breathing chamber and including:
a first nasal assembly connector portion at a first lateral side of the nasal assembly, the first nasal assembly connector portion defining a first passage permitting introduction of pressurized air into the breathing chamber, wherein the first nasal assembly connector portion is formed of a different material than the portion of the nasal assembly shaped to seal around the nasal passages, wherein the portion of the nasal assembly shaped to seal around the nasal passages of the patient is more flexible than the first nasal assembly connector portion, wherein the silicone of the portion of the nasal assembly that is shaped to seal around the nasal passages of the patient surrounds the first nasal assembly connector portion such that the silicone surrounds the first passage that permits introduction of pressurized air into the breathing chamber, and
a second nasal assembly connector portion at a second lateral side of the nasal assembly that is opposite the first lateral side of the nasal assembly, the second nasal assembly connector portion defining a second passage permitting introduction of pressurized air into the breathing chamber, wherein the second nasal assembly connector portion is formed of a different material than the portion of the nasal assembly shaped to seal around the nasal passages, wherein the portion of the nasal assembly shaped to seal around the nasal passages of the patient is more flexible than the second nasal assembly connector portion, wherein the silicone of the portion of the nasal assembly that is shaped to seal around the nasal passages of the patient surrounds the second nasal assembly connector portion such that the silicone surrounds the second passage that permits introduction of pressurized air into the breathing chamber;
a pair of inlet conduits, including a first inlet conduit and a second inlet conduit, to deliver pressurized air from a flow generator to the breathing chamber of the nasal assembly through the first passage of the first nasal assembly connector portion and the second passage of the second nasal assembly connector portion;
a first inlet conduit connector portion that is attached to an end of the first inlet conduit and is removably attachable to the first nasal assembly connector portion, the first inlet conduit connector portion defining a third passage to provide fluid communication between the first inlet conduit and the breathing chamber when the first inlet conduit connector portion is attached to the first nasal assembly connector portion, wherein the first inlet conduit connector portion is formed of a different material than the first inlet conduit; and
a second inlet conduit connector portion that is attached to an end of the second inlet conduit and is removably attachable to the second nasal assembly connector portion, the second inlet conduit connector portion defining a fourth passage to provide fluid communication between the second inlet conduit and the breathing chamber when the second inlet conduit connector portion is attached to the second nasal assembly connector portion, wherein the second inlet conduit connector portion is formed of a different material than the second inlet conduit.

US Pat. No. 10,556,083

PATIENT INTERFACE DEVICE AND MAINTAINING APPARATUS AND MAINTAINING MEMBER THEREFOR

Koninklijke Philips N.V.,...

1. A maintaining member for a patient interface device, the patient interface device comprising a cushion member structured to engage a face of a patient to deliver a flow of breathing gas to an airway of the patient, the maintaining member comprising:a body structured to be disposed on a single side of the face of the patient, the single side of the face of the patient being either a left side of the face or a right side of the face, the body comprising:
a coupling portion structured to be coupled to the cushion member; and
a maintaining portion extending from the coupling portion, the maintaining portion having a receiving portion disposed opposite and facing the coupling portion, the receiving portion being structured to be disposed on a back side of a head of the patient and being concave facing in a direction toward the coupling portion in order to maintain the patient interface device on the face of the patient.

US Pat. No. 10,556,082

CANNULA FOR MINIMIZING DILUTION OF DOSING DURING NITRIC OXIDE DELIVERY

Mallinckrodt Hospital Pro...

1. A nasal cannula for therapeutic gas delivered to a patient in need thereof, comprising:a first lumen, a second lumen, and a third lumen:
the first lumen being a first therapeutic gas lumen for delivering a first therapeutic gas to a patient in need thereof,
the second lumen being a triggering lumen, and
the third lumen being a second therapeutic gas lumen for delivering a second therapeutic gas to the patient; and
a cannula nosepiece allowing separate flow paths to the patient for (i) the first therapeutic gas lumen, (ii) the triggering lumen, and (iii) the second therapeutic gas lumen, wherein the cannula nosepiece inhibits mixing of the first therapeutic gas and the second therapeutic gas in the cannula nosepiece; and
wherein the first lumen has an inner diameter that is smaller than inner diameters of the second lumen and third lumen but larger than an inner diameter of the flow path for the first lumen at the cannula nosepiece.

US Pat. No. 10,556,081

BRAIDED HOSE FOR USE IN SLEEP APNEA TREATMENT SYSTEMS THAT DECOUPLES FORCE

FRESCA MEDICAL, INC., Sa...

1. A method of manufacture of a hose, the method comprising:providing a braided matrix with an interior lumen, the matrix including:
filaments that intersect each other and create a braid;
a longitudinal axis that runs along the lumen, wherein the filaments intersect the longitudinal axis at a braid angle;
and wherein the braid angle can be varied by compressing the matrix along the direction of the longitudinal axis or by expanding the matrix perpendicular to the longitudinal axis;
compressing the matrix so as to increase the braid angle relative to the braid angle of the matrix in the non-compressed state;
stabilizing the braid angle by applying heat to the matrix; and
applying a polymer to the matrix.

US Pat. No. 10,556,080

MASK SYSTEM COMPRISING A COMBINED AIR DELIVERY AND STABILIZING STRUCTURE

ResMed Pty Ltd, Bella Vi...

1. A mask system to deliver respiratory therapy to a patient, the mask system comprising:a patient interface that defines a breathing chamber and is shaped to seal against a face of the patient and deliver pressurized air from the breathing chamber into airways of the patient, the patient interface defining a first inlet port for introduction of pressurized air into the breathing chamber at a first location and a second inlet port for introduction of pressurized air into the breathing chamber at a second location that is spaced apart from the first location; and
a conduit headgear system that provides a combined air delivery and stabilizing structure for the patient interface, the conduit headgear system including:
a first inlet conduit to introduce pressurized air into the breathing chamber of the patient interface through the first inlet port of the patient interface, the first inlet conduit extending across a first side of a head of the patient when the mask system is worn by the patient, the first inlet conduit including a first elongate section that is adapted to extend across the first side of the head of the patient between a first ear of the patient and a first eye of the patient, the first inlet conduit including a first extension that is located above the first ear of the patient and that extends away from the first elongate section of the first inlet conduit towards a back of the head of the patient when the mask system is worn by the patient, wherein the first inlet conduit is biased open, is structured to collapse under weight of the head of the patient against bedding, and does not include anti-crush ribs provided to an inside surface of the first inlet conduit to prevent opposing inner walls of the first inlet conduit from engaging one another;
a second inlet conduit to introduce pressurized air into the breathing chamber of the patient interface through the second inlet port of the patient interface, the second inlet conduit extending across a second side of the head of the patient when the mask system is worn by the patient, the second inlet conduit including a second elongate section that is adapted to extend across the second side of the head of the patient between a second ear of the patient and a second eye of the patient, the second inlet conduit including a second extension that is located above the second ear of the patient and that extends away from the second elongate section of the second inlet conduit towards the back of the head of the patient when the mask system is worn by the patient, wherein the second inlet conduit is biased open, is structured to collapse under weight of the head of the patient against bedding, and does not include anti-crush ribs provided to an inside surface of the second inlet conduit to prevent opposing inner walls of the second inlet conduit from engaging one another;
a manifold to which the first inlet conduit and the second inlet conduit connect, the manifold adapted to receive pressurized air from an air delivery system and provide pressurized air to the first inlet conduit and the second inlet conduit, the manifold shaped to mount atop the head of the patient, the manifold including:
(i) a base portion adapted to contact the head of the patient at a center of the base portion, and connect with the first inlet conduit and the second inlet conduit, wherein the base portion is structured so that a surface of the base portion that is adapted to contact a top of the head of the patient matches a curvature of the top of the head of the patient when the mask system is worn by the patient, and
(ii) an inlet tube portion adapted to receive pressurized air from the air delivery system and connect with the base portion to deliver pressurized air to the base portion, wherein the inlet tube portion is structured to be non-collapsible under weight of the head of the patient against bedding,
wherein the manifold is structured to provide a transition from the first inlet conduit and the second inlet conduit each being structured to collapse under weight of the head of the patient against bedding to the inlet tube portion being structured to be non-collapsible under weight of the head of the patient against bedding; and
a back strap to extend across an occiput of the patient when the mask system is worn by the patient, the back strap connectable with the first extension of the first inlet conduit above the first ear of the patient and connectable with the second extension of the second inlet conduit above the second ear of the patient.

US Pat. No. 10,556,079

BREATHING ASSISTANCE SYSTEM

23. A breathing assistance system comprising:a single flow generator configured to deliver a single continuous unidirectional flow of breathing gas to a user interface, the flow rate exceeding a user's peak inspiratory flow requirements; and
the user interface comprising:
a nasal cannula;
a mask arranged about the nasal cannula, the mask comprising:
a seal configured to seal with a face of the user to allow the pressure within the user's respiratory system to be regulated;
a gas outlet passage through the mask configured to exhaust gases from the mask; and
one or more additional injection ports for supplying gases to a cavity of the mask, separately from the nasal cannula; and
a detachable and flexible delivery conduit comprising an inlet port and an outlet port, wherein the detachable and flexible delivery conduit protruding through the mask and coupled to the nasal cannula, the detachable and flexible delivery conduit configured to supply gases to the nasal cannula, and the one or more additional injection ports formed in the detachable and flexible delivery conduit.

US Pat. No. 10,556,078

CAMERA TUBE WITH GUIDE SURFACE FOR INTUBATION STYLET AND METHOD OF USE

COOKGAS, LLC, St. Louis,...

1. A method comprising:providing a camera tube wherein the camera tube comprises an elongate member having a length extending between opposite distal and proximal ends of the elongate member, the camera tube having a first imaginary line extending from a center of the proximal end and a second imaginary line extending from a center of the distal end, the distal end having a camera, the camera tube having an exterior surface and an intubation stylet guide support extending radially outward from the exterior surface along a portion of the length adjacent to the distal end;
directing a user to:
insert the camera tube in a laryngeal mask;
insert an intubation stylet in the laryngeal mask so that the intubation stylet abuts the camera tube and is supported by the intubation stylet guide support; and
manipulate the camera tube to change an orientation of the intubation stylet within the laryngeal mask.

US Pat. No. 10,556,077

REVERSIBLE AIRWAY DEVICE AND RELATED METHOD FOR VENTILATING A SUBJECT

THE CLEVELAND CLINIC FOUN...

1. A reversible airway device comprising:a tubular guide having a distal end portion, a proximal end portion, and a first passageway extending between the distal and proximal end portions, wherein the tubular guide includes a longitudinal slot partially extending between the distal and proximal end portions thereof when the reversible airway device is configured for ventilation of a patient and when the reversible airway device is configured for intubation of the patient;
a laryngeal mask attached to the distal end portion of the tubular guide, the laryngeal mask including an opening in fluid communication with the first passageway;
an endotracheal tube slidably disposed within the first passageway, the endotracheal tube having a second passageway that is concentric with the first passageway, the longitudinal slot of the tubular guide being sized and dimensioned to receive the endotracheal tube therethrough; and
a sealing mechanism disposed within the first passageway at the distal end portion of the tubular guide and positioned proximate the longitudinal slot, the sealing mechanism being configured to form a fluid-tight seal in the first passageway between the tubular guide and the endotracheal tube so as to occlude a flow of a gas through the first passageway.

US Pat. No. 10,556,076

CUFF PRESSURE ADJUSTING DEVICE

ICST CORPORATION, (JP)

1. A cuff pressure adjusting device comprising:a gas feeding member configured to feed a gas into a cuff for respiratory assistance via a tube by a pressing manipulation that is performed by a user, the cuff being disposed in a trachea or a larynx, the gas feeding member being configured with:
an elastic hollow body configured to be deformed so as to reduce an inner volume of the elastic hollow body with reception of the pressing manipulation so that the gas is fed to the cuff via the tube; and
a support member disposed adjacently to the elastic hollow body in a pressing direction along which the pressing manipulation is performed so as to reduce the inner volume of the elastic hollow body by the pressing manipulation, the support member including a bulging outer periphery that outwardly projects toward the elastic hollow body in the pressing direction;
a cuff pressure detection sensor configured to detect a pressure in the cuff;
a pressing manipulation detection switch configured to detect the pressing manipulation; and
an electronic display configured to display the pressure in the cuff detected by the cuff pressure detection sensor,
wherein a gas feeding amount from the gas feeding member to the cuff via the tube by a single stroke of the pressing manipulation causes a pressure increase of the pressure in the cuff, and the pressure increase is equal to or less than 10.67 cmH2O by the single stroke, and
wherein the pressing manipulation detection switch is provided in the bulging outer periphery of the support member.

US Pat. No. 10,556,075

METHOD AND APPARATUS FOR THE REMOVAL OF ANAESTHETIC AGENTS FROM BREATHING GAS

5. An apparatus for respiration a patient with a breathing gas in which the breathing gas has an anesthetic agent therein, the apparatus comprising:a line system in which a pressure of the breathing gas therein is varied in accordance with a respirating pattern of the patient, said line system having a first connector for supplying the breathing gas to the patient and a second connector adapted to connect with a supply of the breathing gas, the line system having a main portion that leads all of the breathing gas therethrough, a first portion communicating with the main portion, and a second portion communicating with the main portion, the second portion positioned parallel to the first portion;
a blower cooperative with said line system so as to circulate the breathing gas in the main portion, the first portion and the second portion;
an absorber positioned in the main portion of said apparatus so as to remove carbon dioxide from the breathing gas, the second portion of the line system having a filter device therein, said filter device having activated carbon so as to remove the anesthetic agent from the breathing gas, the absorber and the filter device being in series;
a cooler cooperative with said filter, said cooler adapted to cool the breathing gas so that the anesthetic agent condenses on said activated carbon of said filter device; and
a warmer provided to warm the breathing gas after the anesthetic agent has condensed out of the breathing gas.

US Pat. No. 10,556,074

ARTIFICIAL RESPIRATION SYSTEM WITH TIMING CONTROL AND AUTOMATIC MASK DETECTION

Daniel A. McCarthy, Tyle...

1. A ventilator system, comprising:a set of two or more ventilator masks, wherein each of at least two of the ventilator masks is configured in a size that will fit upon a different range of sizes of human faces than at least one other ventilator mask in the set of two or more ventilator masks, wherein each of the at least two ventilator masks comprises a gas flow restrictor that is different from a gas flow restrictor of the other ventilator masks of the at least two ventilator masks; and
a ventilator supply system, comprising:
an air/oxygen source;
a connector configured to couple with each of the at least two ventilator masks;
an air/oxygen supply system comprising a detection system capable of determining a pressure differential created by the application of air/oxygen to a mask coupled to the ventilator supply system, wherein the detection system comprises:
a flow meter which determines the rate of air/oxygen flowing through the detection system;
a first pressure sensor, downstream from the flow meter; and
a second pressure sensor, upstream from the flow meter;
wherein the pressure differential is determined by measuring the difference between the pressure detected by the second pressure sensor and the pressure detected by the first pressure sensor, and
a controller coupled to the detection system, wherein the controller determines, during use, which mask, among the two or more ventilator masks, is coupled to the air/oxygen supply system based on the pressure differential detected by the detection system.

US Pat. No. 10,556,073

THERAPY DEVICE FOR TREATMENT OF RESPIRATORY DISEASES

1. A therapeutic device (1) for the treatment of human respiratory illnesses, said therapeutic device (1) comprising:a mouthpiece (2) having a distal end, a proximal end, and a passage duct (3) extending therebetween, said passage duct (3) having a distal opening on said distal end of said mouthpiece (2) and a proximal opening on said proximal end of said mouthpiece (2), and said passage duct (3) defining a longitudinal axis extending between said distal end of said mouthpiece (2) and said proximal end of said mouthpiece (2);
a hose (5) formed out of a flexible elastic material, said hose (5) comprising a distal end, a proximal end, and a lumen extending therebetween, said proximal end of said hose (5) being mounted to said mouthpiece (2) with said proximal end of said hose (5) being aligned with said distal opening of said passage duct (3) such that said hose is fluidically connected to said passage duct (3), and such that said distal end of said hose is open to atmosphere;
a support body (11) having a proximal portion mounted to said mouthpiece (2) and a distally-extending curved portion for supporting said hose (5) wherein said proximal portion of said support body extends distally from said mouthpiece in a direction that is parallel to said longitudinal axis of said mouthpiece, and said distally-extending curved portion of said support body (11) comprises an arc extending away from said longitudinal axis of said mouthpiece, said arc of said support body defining a radius of curvature; and
an adjusting device (12) having a proximal end and a distal end, said adjusting device (12) passing through said distally-extending curved portion of said support body (11) at a distance from said mouthpiece (2) such that said distal end of said adjusting device (12) engages said hose; a guide plate (14) having a distal end, a proximal end, and a body extending therebetween, said body of said guide plate (14) being disposed between said distal end of said adjusting device (12) and said hose (5), such that said distal end of said adjusting device (12) contacts said body of said guide plate (14) and such that at least a portion of said hose (5) lies loose on said body of said guide plate (14); wherein
said adjusting device (12) is configured to be selectively moved relative to said support body (11), such that a distance between said hose (5) and said support body (11), and a distance between said guide plate (14) and said support body (11) are configured to be selectively adjusted, whereby to selectively vary an arc of said hose relative to said longitudinal axis of said mouthpiece, said adjusting device being configured to adjust a radius of curvature of said guide plate independently to said radius of curvature of said distally-extending curved portion of said support body (11).

US Pat. No. 10,556,072

METERING DEVICE FOR A METERED DOSE INHALER

DunAn Microstaq, Inc., A...

1. An aerosol dispensing apparatus comprising:an aerosol container;
a discharge piece;
an actuator;
a flow control canister valve assembly attached to the aerosol container, and including a substantially cup-shaped retainer, a canister valve seat member mounted within the retainer, and a canister valve seal member mounted within the canister valve seat member;
wherein the retainer includes a post aperture formed in an end wall thereof, and a pin aperture formed in a circumferentially extending wall thereof;
a battery; and
an electronically controlled flow control valve electronically connected to the battery and in fluid communication with the flow control canister valve assembly;
wherein the aerosol container and the attached flow control canister valve assembly are further attached to the actuator and the actuator is mounted for slidable movement within the discharge piece; and
wherein the flow control canister valve assembly is movable between an open position wherein a volume of an aerosol formulation is directed from the aerosol container through the flow control canister valve assembly to the electronically controlled flow control valve, and a closed position wherein the aerosol formulation is not permitted to flow through the flow control canister valve assembly to the electronically controlled flow control valve.

US Pat. No. 10,556,070

DEVICE AND METHOD TO MONITOR, TRACK, MAP AND ANALYZE USAGE OF METERED-DOSE INHALERS IN REAL-TIME

RECIPROCAL LABS CORPORATI...

21. A method comprising:receiving, at a network computer system, a plurality of usage events, each usage event reporting a dispensing of medication by a medicament dispensing device, wherein each usage event comprises a timestamp and a geographical location of the dispensing of the medication and is received from one of a plurality of devices associated with one of a plurality of users;
analyzing the usage events to identify an event of interest based on the timestamps and geographical locations of the received usage events; and
responsive to the analyzing,
preparing a visualization of the event of interest; and
providing the visualization to a user device.

US Pat. No. 10,556,069

INHALER

LUPIN LIMITED, Mumbai (I...

1. An inhaler device comprising:a housing,
a base plate covering the housing,
a medicament holder integrated with the base plate,
a mouthpiece sitting over the base plate,
a lid which covers the mouthpiece,
at least one piercing element,
an actuating member,
a spring,characterized in that a piercing element is attached from inside of the actuating member, the spring is configured to link the actuating member to the medicament holder and the inhaler device is a two hinge system, whereinthe base plate is joined to a first hinge extending through a corresponding first set of apertures in said housing;
the mouthpiece and the lid are joined to a second hinge extending through a corresponding second set of apertures in said housing, wherein the base plate is hinged separately from the mouthpiece and lid.

US Pat. No. 10,556,068

INJECTION DEVICE

Consort Medical PLC, Hem...

1. An injection device comprising:an outer housing configured to receive a syringe, the syringe having a barrel for containing a medicament and a needle in fluid communication with the barrel;
a needle shield axially moveable relative to the outer housing between a needle covering position and a needle exposing position to selectively provide a needle enclosure, the needle exposing position being axially rearward of the needle covering position;
a biasing means for biasing the needle shield axially forwardly toward the needle covering position;
a locking means; and
a locking sleeve axially movable relative to the outer housing between a non-locking position and a locking position, the locking position being axially rearward of the non-locking position, in which axial movement of the locking sleeve is selectively limited by the locking means;
wherein in a first configuration, the needle shield is in the needle covering position and the locking sleeve is in the non-locking position so that at least a portion of the needle shield is axially slideable within the locking sleeve to permit rearward axial movement of the needle shield from the needle covering position to the needle exposing position; and
in a subsequent configuration, the needle shield is in the needle covering position and the locking sleeve is in the locking position so that the needle shield is prevented from moving axially rearwardly by interference with the locking sleeve.

US Pat. No. 10,556,067

AUTOMATIC INJECTION DEVICE FOR MULTIPLE DOSING

Min Wei, Carmel, IN (US)...

1. A medical injection device having a distal end and a proximal end, comprising:a medication container having a movable piston;
a push rod assembly displaceably disposed in said medical injection device, said push rod assembly having a plurality of spaced-apart position setting means disposed along the length thereof, said push rod assembly selectively displacing said movable piston to dispense a medicament from said medication container;
a resilient member configured to bias said push rod assembly to move toward said distal end of said medical injection device;
a releasable restraining member configured to releasably restrain said push rod assembly in a locked state against said biasing of said resilient member, wherein, upon release of said releasable restraining member, said push rod assembly moves under force of said resilient member toward said distal end of said medical injection device;
an activation means configured to release said releasable restraining member; and
a separation spring configured to move said push rod assembly toward said proximal end of said medical injection device.

US Pat. No. 10,556,066

POWER EFFICIENT ELECTRONIC DEVICE

1. An assembly comprising:an electric consumer,
an electric voltage source adapted to power the electric consumer, and being operatable between a first state in which a first voltage is generated and a second state in which a second higher voltage is generated,
a main portion comprising:
a drug reservoir or structure for receiving a drug reservoir, the reservoir comprising an outlet portion,
a dose setting structure,
an expelling structure for expelling a set dose of drug from the reservoir,
the electric voltage source, and
the electric consumer in the form of electronic circuitry,
a cap adapted to be mounted on the main portion to thereby cover the reservoir outlet portion, and
a user operated actuation structure being:
operatable from a first to a second state and adapted to thereby operate the electric voltage source from the first to the second state, and
operatable from the second state to the first state and adapted to the re by operate the electricvoltage source from the second to the first state, wherein the actuation structure is in the form of the cap, the electricvoltage source being operated from the first to the second state and from the second to the first state when the cap is removed from the main portion and mounted on the main portion, respectively.

US Pat. No. 10,556,065

SYRINGE

CC Biotechnology Corporat...

1. A syringe comprisingan injection assembly comprising
a connecting element having
an inner flange formed in the connecting element and having a guiding hole defined through the inner flange; and
multiple unidirectional teeth formed on an inner surface of the connecting element;
a sleeve connected with a rear end of the connecting element and having
an inner front segment;
an inner rear segment communicating with the inner front segment;
a recycling groove defined in an inner surface of the inner rear segment and composed of a spiral groove and a straight groove; and
a resilient limiting tab formed on a rear end of the sleeve;
a guiding tube mounted in the inner front segment of the sleeve and having
a tubular body having a spiral guiding groove defined in an inner surface of the tubular body;
a front tube segment extending out of the inner front segment, extending into the rear end of the connecting element, and having
multiple limiting ratchet tabs formed on an outer surface of the front tube segment and engaged with the unidirectional teeth; and
a shoulder formed between the tubular body and the front tube segment,
a screwing tube mounted in the sleeve and the guiding tube, extending out of the rear ends of the sleeve and the guiding tube and having
an axial hole defined axially through the screwing tube;
a guiding block formed on a front end of the screwing tube and mounted in the spiral guiding groove;
a guiding protrusion formed on an outer surface of the screwing tube, at a middle portion of the screwing tube and being moveable in the recycling groove composed of the spiral groove and the straight groove;
a releasing channel longitudinally defined in the outer surface of the screwing tube and being diametrically opposite to the guiding protrusion;
multiple annular grooves defined around the outer surface of the screwing tube and arranged longitudinally at evenly spaced intervals, wherein the limiting tab on the sleeve is capable of being shifted between the releasing channel and the annular grooves; and
multiple unidirectional ratchet teeth formed on an inner surface of the axial hole;
a screwing collar mounted in the front tube segment of the guiding tube and having a threaded hole;
a pushing rod mounted in the screwing tube and having
a rod body having a non-circular cross section corresponding to a shape of the guiding hole of the connecting element; and
a dose controlling segment formed on a front segment of the rod body and provided with a thread that has a first pitch smaller than a second pitch of the spiral guiding groove, is screwed with the threaded hole in the screwing collar, and extends through the guiding hole in the connecting element;
a unidirectional ratchet collar mounted in the screwing tube, located behind the pushing rod, and having
a collar body; and
multiple unidirectional ratchet tabs formed on and protruding from an outer surface of the collar body and engaged with the unidirectional ratchet teeth of the screwing tube; and
an injection device having
an injection rod moveably extending into the sleeve and the screwing tube, through the ratchet collar, and into the axial hole in the pushing rod; and
an end cap mounted on a rear end of the injection rod and connected rotatably with a rear end of the screwing tube; and
a vial housing connected with the injection assembly.

US Pat. No. 10,556,064

AUTO-INJECTOR

Sanofi-Aventis Deutschlan...

1. An auto-injector for administering a dose of a liquid medicament, the auto-injector comprising:a tubular chassis telescopable in a tubular case;
a carrier subassembly comprising a tubular carrier, a drive spring, and a plunger, wherein the tubular carrier is slidably arranged relative to the tubular chassis inside the tubular case, the tubular carrier configured to contain a syringe with a hollow injection needle, wherein the plunger is configured to forward a load of the drive spring to a stopper of the syringe, and wherein the syringe is lockable for joint axial translation with the tubular carrier;
a control spring arranged around the tubular carrier; and
a syringe retraction control mechanism configured to couple a distal end of the control spring to either the tubular carrier for needle retraction or to the tubular case otherwise.

US Pat. No. 10,556,063

DISTRIBUTED MEDICATION DELIVERY USING AUTONOMOUS DELIVERY DEVICE

1. A medication delivery system for the delivery of medication, the system comprising:a medical delivery operations module comprising a delivery mechanism having a base function of medication delivery at a selectable delivery rate and a selectable delivery volume, the medical delivery operations module further comprising a user interface, a buffer memory, a communications system, an operations module processor, and a base function control program stored in a non-volatile memory that is configured, when accessed and executed, to program the operations module processor to control the operation of the delivery mechanism to perform its base function, wherein the operations module processor is connected to the user interface to receive program instructions to set delivery rate and delivery volume at fixed values;
wherein the communications system is configured to receive an advanced medication delivery program from an advanced interface module and store the advanced medication delivery program in the buffer memory, wherein the advanced medication delivery program has a plurality of different values for at least one of the delivery rate and the delivery volume that vary with time; and
wherein the base function control program also programs the operations module processor to access the buffer memory and when an advanced medication delivery program has been completely loaded into the buffer memory and a “start” instruction is received from the user interface, to execute the advanced medication delivery program under which the operations module processor automatically varies at least one of the rate of delivery and volume of delivery values in accordance with the advanced delivery program, and wherein the operations module processor is programmed to execute the advanced delivery program residing in the buffer memory autonomously without being under real time control of, or dependent on, any remote processor or data source including a processor at the advanced interface module, or the user interface, except that the user interface is usable to start and stop the operations module processor in running the advanced delivery program, but neither the user interface nor any other control or data device can be used to change the advanced program while it is running;
wherein the advanced interface module is connected with the medical delivery operations module to stop execution of the advanced delivery program, to clear the buffer memory, and to store a revised advanced delivery program in the buffer memory; and
wherein when the operations module processor accesses the buffer memory and when the revised advanced medication delivery program has been completely loaded into the buffer memory, and when a start instruction is received, to execute the revised advanced medication delivery program.

US Pat. No. 10,556,062

ELECTRONIC MEDICATION ORDER TRANSFER AND PROCESSING METHODS AND APPARATUS

Baxter International Inc....

1. A pharmacy system for the automated transfer and processing of electronic medication order information to and from a computerized patient care system associated with a healthcare facility, the system comprising:a pharmacy HL7 interface configured to
receive a first HL7 message including information relating to an electronic medication order for a medication that is to be prepared for intravenous administration to a patient, and
transmit a second HL7 message including information relating to preparation of the medication corresponding to the electronic medication order, the information from the second HL7 message being used to bill for the medication corresponding to the electronic medication order;
a pharmacy computer communicatively coupled to the pharmacy HL7 interface and configured to
process the electronic medication order, including accessing electronically at least one medication database or file using information included with the electronic medication order to identify one or more ingredients required to prepare the medication corresponding to the electronic medication order, and
transmit the information, the information including data indicative of the identified one or more ingredients relating to the preparation of the medication corresponding to the electronic medication order; and
a pharmacy workstation located at least in part within an environment suitable for preparing intravenously administered medications and communicatively coupled to the pharmacy computer, the pharmacy workstation configured to
provide instructions for preparing the medication corresponding to the electronic medication order, and
capture the information relating to preparation of the medication corresponding to the electronic medication order.

US Pat. No. 10,556,061

DEVICE, KIT, AND METHOD FOR PRODUCING MEDICALLY-DELIVERABLE INTRAVENOUS SOLUTION

ODSS Holdings, LLC, Gree...

1. A device for producing for immediate intravenous administration to a patient a medically-deliverable intravenous saline solution from a source of water, the device comprising:a housing, the housing defining an inlet and an outlet, the inlet attachable to the source of water for receiving water therefrom, the outlet configured for use in immediate intravenous administration of the medically-deliverable intravenous saline solution to the patient;
a conduit connected to the housing extending from the inlet to the outlet;
a purification device located within the housing along the conduit downstream of the inlet for purifying the water received from the source of water;
a pump within the housing for pumping the water through the conduit;
a container connectable to the housing holding a concentrated intravenous saline solution, the container having an outlet in communication with the conduit;
a metering device for dispensing the concentrated intravenous saline solution from the container into the water within the conduit; and
a controller connected to the housing for controlling the pump and the metering device so as to create the medically-deliverable intravenous saline solution from the water and the concentrated intravenous solution within the conduit and to deliver the medically-deliverable intravenous saline solution to the outlet for immediate intravenous administration to the patient.

US Pat. No. 10,556,060

DRUG DELIVERY PROGRAMMING TECHNIQUES

Medtronic, Inc., Minneap...

1. A method comprising:controlling, by one or more processors, a medical pump of a fluid delivery system to deliver a first fluid out of an outlet of a fluid path at a first flow rate according to a first drug delivery schedule, wherein the medical pump and a catheter of the fluid delivery system define at least a portion of the fluid path;
controlling, by the one or more processors, the medical pump to deliver a second fluid out of the outlet of the fluid path at a second flow rate according to a second drug delivery schedule after delivery of the first fluid according to the first drug delivery schedule, wherein the second fluid comprises a therapeutic agent;
determining, by the one or more processors and based on at least the first drug delivery schedule of the first fluid, a third flow rate of a mixed fluid located between the first fluid and the second fluid in the fluid path, wherein the mixed fluid comprises a mixture of the first fluid and the second fluid; and
controlling, by the one or more processors, the medical pump to deliver the mixed fluid out of the outlet of the fluid path according to the third flow rate.

US Pat. No. 10,556,059

INFUSION PUMP DRIVE WITH COMPRESSION SPRING

Biogen MA Inc., Cambridg...

1. An infusion pump drive comprising:a transmission;
a spring in line with the transmission, wherein the spring is positioned between the transmission and a portion of a reservoir associated with the spring; and
a motor operatively coupled to the transmission;
wherein the transmission is displaceable to compress the spring causing a force to be applied by the compressed spring, the applied force sufficient to dispense a fluid from the reservoir associated with the spring.

US Pat. No. 10,556,058

APPARATUS FOR SECURELY AND GENTLY HOLDING A FLEXIBLE ELONGATED MEDICAL DEVICE

Cath Lab Solutions LLC, ...

1. A clip for holding a flexible elongated medical device, the clip comprising:a hinge;
first and second jaws movable with respect to each other about the hinge from a closed position to an open position, each of the jaws having a contact surface, the contact surface of the first jaw being disposed against the contact surface of the second jaw when the clip is in the closed position and away from the contact surface of the second jaw when the clip is in the open position; and
flexible material disposed on at least one of the jaws, the flexible material comprising the contact surface, wherein the flexible material comprises PORON Medical® urethane.

US Pat. No. 10,556,057

MICRO-FLUIDIC CHAMBERS FOR USE IN LIQUID MEDICAMENT DELIVERY SYSTEMS

Roche Diabetes Care, Inc,...

1. A micro-fluidic chamber for use in a liquid medicament delivery system, the micro-fluidic chamber comprising:a bottom substrate and a top cover, the top cover being spaced from the bottom substrate so as to define a height of the micro-fluidic chamber;
wherein, two or more walls or fillings are positioned in the micro-fluidic chamber, the walls or fillings forming a fluid channel between the walls or fillings, the fluid channel extending uninterrupted from an inlet conduit connected to an inlet of the micro-fluidic chamber to an outlet conduit connected to an outlet of the micro-fluidic chamber;
wherein, each of the walls or fillings has a height less than the height of the micro-fluidic chamber so as to define a fluid gap between a top surface of each wall or filling and the top cover; and
wherein, the dimensions of the walls or fillings and the micro-fluidic chamber are such that the fluid gap will be filled with liquid by capillary forces via the fluid channel when liquid is introduced into the micro-fluidic chamber;
wherein, the top cover comprises a flexible membrane; and
wherein, the fluid channel comprises a meander-like shape.

US Pat. No. 10,556,056

ANGULAR CAP FOR DISPENSING LIQUIDS

1. A cap comprising:an elongated body defining a first channel extending from a first opening in a base portion of the elongated body through a neck portion of the elongated body to a second opening in a tip portion of the elongated body;
a side body defining a second channel extending from the first channel near the neck portion of the elongated body to a third opening at a distal end of the side body,
wherein the cap has only three openings and defines:
a first longitudinal axis through a center of the first opening in the base portion, a second longitudinal axis through the tip portion, and a third longitudinal axis through the side body,
wherein the first longitudinal axis forms a first acute angle with the second longitudinal axis and the second longitudinal axis forms a second acute angle with the third axis, and
wherein the base portion is adapted to couple to a container;
wherein the cap defines a first plane through the first channel and the second channel, and a second plane orthogonal to the first plane, said first plane and second plane including the first longitudinal axis, and the second opening and the third opening are on a common side of the second plane.

US Pat. No. 10,556,055

METHOD FOR COLLECTING A DESIRED BLOOD COMPONENT AND PERFORMING A PHOTOPHERESIS TREATMENT

Mallinckrodt Hospital Pro...

1. An apparatus for carrying out a method for separating and collecting at least one blood component, the apparatus comprising a disposable kit, the disposable kit comprising:a centrifuge bowl comprising:
an inlet port;
a first outlet port; and
a second outlet port;
a treatment bag fluidly connectable with the first outlet port of the centrifuge bowl; and
a return bag fluidly connectable with the second outlet port of the centrifuge bowl;
a hematocrit sensor in a flow path between the first outlet port of the centrifuge bowl and the treatment bag; and
a cassette for controlling the movement of blood fluids pumped to the centrifuge bowl;
the apparatus being configured to carry out a method comprising:
combining an anticoagulant agent with whole blood at a selected ratio of the anticoagulant agent to the whole blood;
pumping at least a portion of the combination of the whole blood and the anticoagulant agent through the cassette and into the centrifuge bowl through the inlet port of the centrifuge bowl;
operating the centrifuge bowl to displace air and separate the at least a portion of the combination of the whole blood and the anticoagulant agent into a plurality of separated blood components according to density, the plurality of separated blood components comprising at least plasma, red blood cells, and buffy coat;
until a collection of the buffy coat in the centrifuge bowl is initiated and where the buffy coat will then be directed out of the centrifuge bowl through the first outlet port and thereafter into the treatment bag:
withdrawing at least a portion of the plasma accumulating in the centrifuge bowl through the first outlet port and directing this plasma into the return bag, and after an interface between the buffy coat and the red blood cells in the centrifuge bowl reaches a predetermined position within the centrifuge bowl based upon red blood cells accumulating in the centrifuge bowl, withdrawing at least a portion of the red blood cells accumulating in the centrifuge bowl through the second outlet port and directing these red blood cells into the return bag, wherein the withdrawal of plasma and red bloods cells from the centrifuge bowl through the first and second outlet ports, respectively, as the at least a portion of the whole blood and the anticoagulant agent continues to be pumped into the centrifuge bowl through the inlet port, allows for accumulation of buffy coat within the centrifuge bowl; and
initiating a collection of the buffy coat from the centrifuge bowl and comprising allowing the red blood cells accumulating in the centrifuge bowl to push at least a portion of the buffy coat that has accumulated in the centrifuge bowl out of the centrifuge bowl through the first outlet port and into treatment bag until the hematocrit sensor detects a presence of the red blood cells.

US Pat. No. 10,556,054

BLOOD LEAKAGE WARNING DEVICE FOR DIALYSIS PATIENT

1. A blood leakage warning device for dialysis patient used for identifying the blood leakage at an injection site, comprises:a cover absorber, covering the injection site used for absorbing blood leakage;
two detection modules, being disposed on the cover absorber at intervals;
a control module, being electrically connected to the two detection modules for detecting whether the cover absorber absorbs the blood; and
an alarm module, being electrically connected the control module, and the alarm module issuing an alarm when the cover absorber absorbs the blood;
wherein the cover absorber is made from fibrous materials, each of the two detection modules is a clamp, and the two detection modules clamp the cover absorber; and
wherein when the cover absorber does not absorb the blood, a resistance value between the two detection modules represents an open circuit, and when the cover absorber module absorbs the blood, a resistance value between the two detection modules represents a short circuit.

US Pat. No. 10,556,053

SYSTEM FOR COLLECTING MONONUCLEAR CELLS HAVING A SUITABLE HEMATOCRIT FOR EXTRACORPOREAL PHOTOPHERESIS

Fenwal, Inc., Lake Zuric...

1. A system for collecting mononuclear cells to be treated with UV irradiation, comprising: a disposable fluid circuit comprising a processing container, a product container configured to receive a mononuclear cell product comprising mononuclear cells, red blood cells, and plasma, a tubing connecting the processing container to the product container; a separator configured to work in association with the disposable fluid circuit, the separator comprising a chamber configured to receive the processing container, rotate about a rotational axis and convey whole blood into an inlet region of the chamber for separation into a red blood cell constituent, a plasma constituent, and an interface constituent carrying mononuclear cells between the red blood cell constituent and the plasma constituent, a valve for selectively permitting fluid flow through the tubing, an optical or hematocrit sensor configured to detect transmission levels of light passing through separated blood components flowing out of the processing container through the tubing; a microprocessor-based controller in communication with the separator, wherein the controller is programmed to: receive input of a target hematocrit for the mononuclear cell product, wherein hematocrit is determined by a ratio of the red blood cells per volume within the mononuclear cell product; receive input for a total volume of whole blood to be processed and a number of cycles to be performed; direct the interface constituent and a portion of the red blood cell constituent into the product container by opening the valve disposed between the processing container and the product container to collect a resulting mononuclear cell product volume comprising a volume of mononuclear cells and a volume of red blood cells; and automatically adjust the volume of red blood cells flowed to the product container based on input from the optical or hematocrit sensor so that a ratio of total volume of red blood cells within the mononuclear cell product to a total volume of mononuclear cell product equals the target hematocrit.

US Pat. No. 10,556,052

CONTROL SYSTEM

Spectrum Medical Ltd., G...

1. A control system controlling at least one blood gas value in blood processed by an oxygenator of an extracorporeal perfusion system, wherein the oxygenator is configured to generate arterial blood by exposing venous blood to oxygen from an oxygenation gas supply, the control system comprising:a monitoring arrangement to determine a level of the at least one blood gas value in the arterial blood,
a blender having a plurality of gas inlets and a mixing chamber operable to provide the oxygenation gas supply, and
a controller responsive to the monitoring arrangement, the controller configured to control parameters of the oxygenation gas supply to the oxygenator, to adjust at least one of the blood gas values toward a pre-determined level, and wherein the controller comprises a configuration permitting it to alter the composition and a flow rate of the oxygenation gas supplied to the oxygenator,
wherein the controller is configured to simultaneously control the partial pressure of oxygen in the arterial blood and the partial pressure of carbon dioxide in the arterial blood by setting the flow rate of the oxygenation gas supply from the mixing chamber to a level suitable for adjusting the partial pressure of carbon dioxide, and at the set flow rate, setting the fraction of oxygen in the mixing chamber so that the fraction of oxygen in the oxygenation gas supply is at a level suitable for adjusting the partial pressure of oxygen.

US Pat. No. 10,556,051

MEDICAL DEVICE WITH OPERATOR SUPPORT

Fresenius Medical Care De...

1. A medical device, comprising:a display configured to provide a user interface;
an actuator or sensor;
and
a control unit, connected to the actuator or sensor and to the display;
wherein the control unit is configured to:
control the user interface to display a touch key corresponding to a search function;
receive, via the user interface, user input corresponding to selection of the touch key corresponding to the search function;
control the user interface to display a search window in response to receiving the user input corresponding to selection of the touch key corresponding to the search function, wherein the search window comprises a search field;
receive, via the user interface, user input corresponding to entry of a partial text string into the search field;
control the user interface to display one or more full text strings corresponding to the partial text string in response to receiving the user input corresponding to entry of the partial text string, wherein the one or more full text strings include a full text string corresponding to the actuator or sensor;
receive, via the user interface, user input corresponding to selection of the full text string corresponding to the actuator or sensor;
control the user interface to display text passages and/or graphics relating to the actuator or sensor in response to receiving the user input corresponding to selection of the full text string corresponding to the actuator or sensor;
receive, via the user interface, user input corresponding to selection of a displayed text passage or graphic relating to the actuator or sensor;
control the user interface to display an actuator or sensor interface corresponding to the actuator or sensor in response to receiving the user input corresponding to selection of the displayed text passage or graphic relating to the actuator or sensor;
receive, via the user interface, user input on the actuator or sensor interface for adjustment of an operating parameter relating to the actuator or sensor; and
adjust the operating parameter relating to the actuator or sensor based on the received user input for adjustment of the operating parameter relating to the actuator or sensor.

US Pat. No. 10,556,050

LOW COST VENTRICULAR DEVICE AND SYSTEM THEREOF

Thorvascular Pty Ltd, Fr...

1. A centrifugal blood pump device comprising:an impeller having a plurality of blades, the blades including blade magnets; and
a pump housing having an inlet, an outlet, a cavity, and housing magnets; and
a detachable drive unit;
wherein the inlet is for receiving blood and directing the blood onto the impeller,
wherein the impeller rotates around a central axis thereof in the cavity of the pump housing, and
wherein the impeller, in use, is suspended in the cavity by the blades which generate a centrifugal force acting on the blades in a radial direction away from the central axis and a magnetic repulsive force induced between the blade magnets of the blades and the housing magnets of the pump housing.

US Pat. No. 10,556,049

TWISTING BIVENTRICULAR CARDIAC ASSIST DEVICE

1. A cardiac assist device, comprising:a structure surrounding at least a portion of a heart, wherein the structure comprises:
a first ring on a first side of the structure;
a second ring on a second side of the structure; and
a plurality of columns connecting the first ring to the second ring;
an inner cup enclosing at least a portion of the structure;
an outer cup enclosing at least a portion of the inner cup, wherein; the outer cup comprises an opening; and
a pump, wherein the pump is configured to:
conduct gas into a space between the outer cup and the inner cup via the opening of the outer cup, wherein the conduction of the gas into the space between the outer cup and the inner cup causes a first motion of the structure comprising a first rotation of the second ring in a first direction; and
conduct the gas from the space between the outer cup and the inner cup to outside of the outer cup via the opening of the outer cup, wherein the conduction of the gas from the space between the outer cup and the inner cup to the outside of the outer cup causes a second motion of the structure comprising a second rotation of the second ring in a second direction, different than the first direction.

US Pat. No. 10,556,048

BLOOD PUMP WITH IN-SITU ATTACHING MOTOR STATORS

HeartWare, Inc., Miami L...

1. A blood pump, comprising:a housing having an interior and an exterior, the housing defining a housing axis and an axial direction along the housing axis;
a pump rotor configured to be received within the interior of the housing, the pump rotor including a magnet; and
a stator having a plurality of stator units, each stator unit having a coil and a delivery configuration and an operative configuration, the plurality of stator units in the delivery configuration having a delivery diameter, each stator unit being configured to slide successively along a common shaft, the plurality of stators units in the operative configuration being configured to:
be disposed around the exterior of the housing; and
form an assembled pump having a diameter greater than the delivery diameter.

US Pat. No. 10,556,047

HEART HELP DEVICE, SYSTEM, AND METHOD

1. An implantable device for improving a pump function of a heart of a human patient by applying an external force on a heart muscle, said device comprising at least one pump device adapted to assist in the pump function of the heart comprising:a heart contacting organ adapted to be located onto the heart muscle,
an operating device for operating the heart contacting organ, and
an implantable pressurized fluid system comprising:
a first implantable chamber adapted to hold a pressurized fluid, wherein said first chamber is adapted to hold a fluid having a high pressure and
a second implantable chamber adapted to hold a pressurized fluid, wherein said second chamber is adapted to hold a fluid having a lower pressure, and
wherein said implantable operating device is adapted to use said first implantable chamber for operating the heart contacting organ in two directions with high pressure fluid, and wherein said operating device is further adapted to use said implantable second chamber for lowering a pressure on one side of said operating device, and
wherein a movement of the heart contacting organ assists the pump function of the heart.

US Pat. No. 10,556,046

BONE MARROW HARVESTING NEEDLE IMPROVEMENTS

EndoCellutions, Inc., Ma...

1. A bone marrow aspiration device comprising:an introducer needle assembly including
an introducer cannula having a proximal end and a distal end, each end including an opening,
a screw assembly coupled to the introducer cannula, the screw assembly including a threaded tube and a lead screw receivable in the threaded tube, and
an outer cover coupled to the screw assembly and being disposed around and in sealing engagement with the threaded tube and the lead screw; and
an aspiration needle assembly to couple to the introducer needle assembly, the aspiration needle assembly including
an aspiration cannula receivable in the introducer cannula, the aspiration cannula having a proximal end and a distal end and including a distal flexible portion that extends along a length of the aspiration cannula, the aspiration cannula forming a channel for aspirating bone marrow,
a length of the aspiration cannula that extends beyond the distal end of the introducer cannula being adjustable by advancing the lead screw into the threaded tube or reversing the lead screw out of the threaded tube.

US Pat. No. 10,556,045

SYNCHRONOUS PRESSURE SAMPLING AND SUPPLY OF NEGATIVE PRESSURE IN NEGATIVE PRESSURE WOUND THERAPY

1. An apparatus for applying negative pressure therapy to a wound, the apparatus comprising:a housing comprising a source of negative pressure configured to be in fluidic communication with a wound dressing, the source of negative pressure comprising at least one valve;
a pressure sensor configured to measure pressure in a fluid flow path configured to fluidically connect the wound dressing and the source of negative pressure; and
a controller configured to operate the source of negative pressure using a drive signal, the controller further configured to:
determine a pressure measurement based on the pressure measured by the pressure sensor, wherein the determination is performed synchronous with operation of the source of negative pressure, and
generate the drive signal based at least on the determined pressure.

US Pat. No. 10,556,044

REDUCED-PRESSURE DRESSING CONNECTION PADS, SYSTEMS, AND METHODS

KCI Licensing, Inc., San...

1. A method for alleviating a vacuum lock during a reduced-pressure treatment of a tissue site, the method comprising:applying a reduced pressure to the tissue site utilizing a treatment system;
sealing a dressing valve of the treatment system at a first threshold pressure; and
if the reduced pressure decreases, unsealing the dressing valve to release a working gas into one or more venting apertures of the dressing valve for extraction by a body conduit of the treatment system to alleviate vacuum lock, wherein the reduced pressure decrease corresponds to an increase in absolute pressure underneath the dressing.

US Pat. No. 10,556,043

REDUCED-PRESSURE, MULTI-ORIENTATION, LIQUID-COLLECTION CANISTER

KCI Licensing, Inc., San...

1. A canister for collecting liquid from a tissue site to which reduced pressure treatment is applied, the canister comprising:at least one canister wall defining a first space configured to collect liquid from the tissue site;
a canister outlet configured to allow communication between a reduced pressure source and the first space;
an elongated member fluidly connected to the canister outlet and extending away from the canister outlet into the first space, the elongated member having a membrane defining a second space along at least a portion of a length of the elongated member, at least a portion of the membrane allowing gaseous communication between the first space and the second space; and
a biasing member surrounded by the membrane and configured to reduce collapse of the elongated member when the second space is exposed to reduced pressure.

US Pat. No. 10,556,042

DRUG DELIVERY SYSTEM AND METHOD OF MANUFACTURING THEREOF

Exogenesis Corporation, ...

1. A method of modifying a flat surface of a medical device comprising the steps:a. depositing a first drug coating layer on the flat surface of the medical device;
b. optionally depositing one or more additional drug coating layers on the first drug coating layer to form a plurality of drug coating layers;
c. forming an accelerated Neutral Beam from a gas cluster ion beam from which charged particles have been separated, including the steps of
accelerating and focusing the gas cluster ions to form an accelerated and focused gas cluster ion beam along a beam path;
promoting fragmentation and/or dissociation of the accelerated and focused gas cluster ions along the beam path while substantially retaining the focus of the gas cluster ion-beam; and
removing charged particles from the beam path to form an accelerated and focused neutral beam along the beam path;
and
d. irradiating a first exposed surface of the first drug coating layer or any additional drug coating layer with the accelerated Neutral Beam to form a barrier layer at the first exposed surface.

US Pat. No. 10,556,041

COATING AGENT AND MEDICAL INSTRUMENT SURFACE TREATED WITH COATING AGENT

TERUMO KABUSHIKI KAISHA, ...

1. A coating agent comprising:(a) a hydroxyl-group-containing polyorganosiloxane represented by the following general formula (1):

wherein each R1 and each R1? independently represents a monovalent hydrocarbon group or a hydroxyl group (—OH), provided that at least one of R1 and at least one of R1? is the hydroxyl group (—OH),
each R2 independently represents a monovalent hydrocarbon group, and
m is an integer of 1,000 to 30,000;
(b) a polydiorganosiloxane represented by the following general formula (2):

wherein each R4 and R5 independently represents a monovalent hydrocarbon group, and
n is an integer of 8 to 1,000; and
(c) an amino-group-containing polyorganosiloxane containing at least one amino group in one molecule thereof represented by the following general formula (3):

where each R6 independently represents a monovalent hydrocarbon group or a —OR9 group, wherein each R9 independently represents a substituted or unsubstituted C1-C4 monovalent hydrocarbon group,
each R7 and each R8 independently represents a monovalent hydrocarbon group,
each A independently represents an amino-group-containing group,
a ratio of p:q is in a range of from 5:1 to 100:1, and
q is an integer of 1 to 100,
wherein the polydiorganosiloxane (b) is contained in a proportion of a mass ratio to the amino-group-containing polyorganosiloxane (c) of from 0.7:1 to 3.0:1, and
the hydroxyl-group-containing polyorganosiloxane (a) is contained in a proportion of 2.4 to 5.5 mass %, based on the total mass of the hydroxyl-group-containing polyorganosiloxane (a), the polydiorganosiloxane (b), and the amino-group-containing polyorganosiloxane (c).

US Pat. No. 10,556,039

PLATELET-DERIVED GROWTH FACTOR COMPOSITIONS AND METHODS FOR THE TREATMENT OF TENDON AND LIGAMENT INJURIES

BIOMIMETIC THERAPEUTICS, ...

1. A method for attaching a ligament to a bone in an individual comprising administering at an interface between the tendon and the bone or the ligament and the bone an effective amount of a composition comprising: a solution of platelet-derived growth factor (PDGF) at a concentration of 0.1 to 2.0 mg/mL disposed in a biocompatible collagen matrix, wherein the biocompatible collagen matrix has a porosity of at least 80%, and wherein at least about 50% of the PDGF is released within about 24 hours.

US Pat. No. 10,556,037

ENZYMATIC WOUND DEBRIDING COMPOSITIONS WITH ENHANCED ENZYMATIC ACTIVITY

1. An anhydrous enzymatic wound debriding composition comprising:(a) a hydrophilic dispersed phase comprising PEG 400 and collagenase; and
(b) a hydrophobic continuous phase comprising a hydrophobic base, wherein the hydrophilic dispersed phase is dispersed in the hydrophobic continuous phase,
wherein the amount of PEG 400 is 10-30% w/w of the composition,
wherein the composition is anhydrous, and
wherein the hydrophobic base comprises one or more of isoparaffin, microcrystalline wax, heavy mineral oil, light mineral oil, ozokerite, petrolatum, or paraffin.

US Pat. No. 10,556,036

ABSORBENT ARTICLE INCLUDING HYDROPHOBIZED ADSORBENT

LIVEDO CORPORATION, Shik...

1. An absorbent article comprising:an absorbent body composed of at least one absorption layer,
wherein the absorbent body includes a hydrophobized adsorbent and a water absorbent resin powder having (a) an absorption speed in a range from 6 seconds to 60 seconds determined by a vortex method, and
wherein the hydrophobized adsorbent is provided on a skin surface side of the absorbent body, relative to the water absorbent resin powder having (a) the absorption speed in the range of from 6 seconds to 60 seconds determined by the vortex method,
wherein the hydrophobized adsorbent is hydrophobized silica having an volume average particle diameter of 2 to 16 nm.

US Pat. No. 10,556,035

SWITCHABLE GAS AND LIQUID RELEASE AND DELIVERY DEVICES, SYSTEMS, AND METHODS

The Regents of the Univer...

1. A device capable of delivering a scent, comprising:a head-wearable or body-wearable piece configured to be attached to or on a person's head or body part, respectively; and
a scent delivery device attached to the head-wearable or body-wearable piece and operable to deliver a scent, the scent deliver device includes a cartridge structured to store one or more scented substances, at least one transporting channel coupled to the cartridge to receive and transport the one or more stored scented substances and configured to include an end opening for releasing the transported one or more stored scented substances, and an actuator switch coupled to the transporting channel and operable to move between an open position and a closed position based on an applied signal to selectively allow passage of the one or more scented substances to the opening,
wherein the actuator switch include magnetically latchable gating structures including a first and a second mating magnetic components that are coupled in the closed position and uncoupled in the open position,
wherein the first mating magnetic component includes a solenoid formed of a solenoid core having a substantially square-loop magnetization loop material, and
wherein the second mating magnetic component is structured to bend or change its translational position upon a change in magnetic field from the solenoid core to actuate the opening or closing of the actuator switch in the transporting channel.

US Pat. No. 10,556,034

SWITCHABLE DIGITAL SCENT GENERATION AND RELEASE, AND VAPOR AND LIQUID DELIVERY METHODS AND SYSTEMS

The Regents of the Univer...

1. A digitally controllable scent creation and delivery apparatus, comprising:an array of containers, each container having an inlet through which an input carrier gas flows in, a chamber, called a scent container, for holding a material containing an elementary or a base chemical producing a characteristic odor, called a scent ingredient, or an ingredient, and an outlet through which a mixture of the input gas and the scent ingredient flows out;
a flow regulation mechanism that controls gas flow through each container based on electromagnetic signals;
one or more blending chambers coupled to outlets of the containers and having a delivery channel outlet, the blending chambers allowing individual outputs from the outlets of the containers to blend together homogeneously to generate a scent and flow the scent out through the delivery channel outlet; and
a pressurization chamber coupled to inlets of the containers, and generating the input carrier gas flows,
wherein the flow regulation mechanism includes a bank of valves coupled to inlets of containers of the array, the valve being operable to control flow of the input gas into inlets of the valves based on the electromagnetic signals, wherein valves in the bank comprise:
an actuator switch operable to move between an open position and a closed position based on an applied electromagnetic signal to selectively allow passage of gaseous material via a transporting channel from an input of the valve to an output of the valve, and
wherein the actuator switch includes:
a magnetically latchable gating valve assembly structured to include (i) a base structure inside the transporting channel and including a high permeability material that forms a passage through the base structure, and (ii) a magnetizable pin assembly set against the base structure in the transporting channel and including a solenoid component, a substantially square-loop magnetization material forming the pin component, and a guide structure containing the pin component,
wherein the magnetizable pin component is in contact with the base structure blocking an opening of the passage when the actuator switch is in the closed position, and the magnetizable pin component, when demagnetized, is not in contact with the base structure when the actuator switch is in the open position exposing the opening of the passage,
wherein the magnetizable pin has a magnetic switching coercivity of less than 200 oersted;
and wherein the pin component is moveable in the guide structure to move upon a change in a surrounding solenoid's magnetic field to actuate the opening or closing of the actuator switch in the transporting channel.

US Pat. No. 10,556,033

SURFACE COATING FOR A MEDICAL INSTRUMENT, MEDICAL INSTRUMENT HAVING A SURFACE COATING, AND METHOD FOR PRODUCING A SURFACE COATING FOR A MEDICAL INSTRUMENT

IMT MASKEN UND TEILUNGEN ...

1. A surface coating for a medical instrument, the surface coating comprising:an interference filter having at least one dielectric layer and at least one metallic layer arranged one above another,
wherein at least one of the at least one metallic layer and the at least one dielectric layer is adapted to be structurally altered by action of a corrosive environment on the surface coating such that the surface coating is convertible from a first state to a second state,
wherein, in the first state, the surface coating has a first spectral reflectivity and, in the second state, the surface coating has a second spectral reflectivity that is different from the first spectral reflectivity, and
wherein the first spectral reflectivity has a first reflectivity maximum at a first wavelength, and the second spectral reflectivity has a second reflectivity maximum at a second wavelength, a difference between the second wavelength and the first wavelength being at least 100 nm.

US Pat. No. 10,556,032

SANITATION MONITORING SYSTEM USING PATHOGEN SURROGATES AND SURROGATE TRACKING

SafeTraces, Inc., Pleasa...

1. A sanitation management system comprising:a computer capable of maintaining records of exemplary locations on an item to be sanitized and records of where a pathogen surrogate was applied prior to a sanitation process;
an augmented reality display that can display marks corresponding to the exemplary locations;
an interface of an augmented reality system that records information about how the pathogen surrogate was applied to the exemplary locations, wherein the pathogen surrogate is comprises a DNA sequence corresponding to an N-bit tag value and a carrier bound to the DNA sequence that is non-toxic and selected to have a degradation rate comparable to a pathogen degradation rate of a pathogen for which the pathogen surrogate is a surrogate under the sanitation process:
an inspection interface of the augmented reality display, capable of displaying sampling locations at which to check for presence of the pathogen surrogate at some or all of the exemplary locations;
wherein carriers of the pathogen surrogates of the plurality of pathogen surrogates have varying levels of resilience to the sanitation process, from low resilience to high resilience, whereby a low resilience carrier is more easily removed during the sanitation process as compared to a high resilience carrier, to provide an indication of a degree of sanitation.

US Pat. No. 10,556,031

DEVICE FOR COUNTING STERILIZATION CYCLES

Aesculap AG, (DE)

1. A device for counting sterilization cycles during the sterilization of medical instruments and medical devices, the device comprising:a counter for recording and reproducing a number of sterilization cycles;
an actuation unit for a sterilization parameter-dependent actuation of the counter; and
a locking unit for a sterilization parameter-dependent locking of the counter, wherein
the actuation unit comprises a stud/pin for actuating the counter and a piston/cylinder unit having a chamber that can be acted upon by a sterilization pressure, the piston/cylinder unit comprising a piston and a cylinder being capable of being positioned relative to each other depending on the sterilization pressure; and wherein
the locking unit comprises a disc which can be moved with respect to the piston/cylinder unit and has a passage for the actuation unit, said passage being positioned so as to be in alignment with the stud/pin and allowing an actuation of the counter when the disc is in a first position and locks the stud/pin and prevents the counter from being activated when the disc is in a second position.

US Pat. No. 10,556,030

DISINFECTANT SPRAY CLEANER DISPENSER PACKAGE

BISSELL Homecare, Inc., ...

1. A disinfectant spray cleaner dispenser package, comprising:a dispensing container;
a bag on valve assembly comprising a dispensing valve mounted to the dispensing container and a flexible pouch within the dispensing container and having an open end that is sealed to the dispensing valve, the flexible pouch including multiple layers of flexible material with each of the multiple layers of flexible material interspersed with an adhesive layer, wherein each of the multiple layers of flexible material interspersed with an adhesive layer comprise multiple laminated layers and the multiple layers of flexible material interspersed with an adhesive layer comprise at least:
a) a polyethylene terephthalate layer,
b) an aluminum layer,
c) a polyamide layer,
d) a polypropylene layer, and
e) an adhesive layer between each of the layers a, b, c, and d; and an enhanced activity aqueous hydrogen peroxide disinfectant solution within the flexible pouch, wherein the enhanced activity aqueous hydrogen peroxide disinfectant solution has a pH of from about 0.5 to about 6 and comprises:
hydrogen peroxide in a concentration of from about 0.05 to about 8 w/w % of the total solution; and
at least one anionic surfactant.

US Pat. No. 10,556,029

OZONE GENERATION DEVICE

USHIO DENKI KABUSHIKI KAI...

1. An ozone generation device comprising:a casing;
a wall body partitioning a space surrounded by the casing into at least a first chamber and a second chamber;
a first opening and a second opening provided in a part of the casing to communicate an outer side of the casing and the first chamber;
a blower mounted at a position inside the wall body or outside the wall body to communicate the first chamber and the second chamber;
a third opening provided in a part of the casing to communicate the outer side of the casing and the second chamber;
a light source body provided between the blower and the third opening in the second chamber and configured to emit ultraviolet light; and
an electrical body provided in a position between the first opening and the second opening in the first chamber and configured to supply electric power for driving the light source body,
wherein the first opening and the second opening are provided at positions separated along a first direction and are communicated inside the first chamber,
the electrical body is provided at the position between the first opening and the second opening in the first chamber in the first direction, and
the third opening is provided on a side opposite to the second opening with respect to the first direction when the first opening is used as a reference.

US Pat. No. 10,556,028

METHOD AND APPARATUS FOR STERILIZING FILLING NOZZLE

Dai Nippon Printing Co., ...

1. A method for sterilizing a filling nozzle, wherein hot water or a liquid chemical agent is fed to drink supply piping that feeds a drink to a plurality of filling nozzles at the same time to perform a sterilization process within an aseptic chamber, a flow rate of the hot water or liquid chemical agent is detected at all the filling nozzles while the hot water or liquid chemical agent is being discharged from all the filling nozzles, a representative temperature of the hot water or liquid chemical agent at least on a downstream side of at least one filling nozzle is measured, an F value is calculated based on the representative temperature, and the sterilization process is ended when both the flow rate at each filling nozzle and the F value calculated based on the representative temperature reach respective target values, whereina SIP (Sterilizing in Place) cup is connected to a nozzle mouth of each filling nozzle and a drain pipe formed by a flexible pipe is connected to each SIP cup, the drain pipe is provided with a temperature sensor, a return pipe extends from the drain pipe to a manifold valve and the return pipe is provided with a heater,
information about the representative temperature measured by the temperature sensor is transmitted to a controller, the controller compares the representative temperature measured with a reference temperature and provides a predetermined output, and the hot water or liquid chemical agent is heated to a predetermined temperature by the heater and is circulated in an annular flow path formed by the drink supply piping, the drain pipe and the return pipe, and
the representative temperature of the hot water or liquid chemical agent on the downstream side of the at least one filling nozzle is measured by the temperature sensor provided in the drain pipe at a part outside the aseptic chamber.

US Pat. No. 10,556,027

METHOD AND APPARATUS FOR STERILIZING A SURFACE

1. A non-transitory computer-readable medium storing instructions which, when executed by a processor, cause the processor to perform operations, the operations comprising:detecting a proximity of a surface of at least one item stored within an enclosure to an ultraviolet light emitting unit, wherein the proximity of the surface to the ultraviolet light emitting unit is detected without contacting the surface; and
activating the ultraviolet light emitting unit to sterilize the surface in response to the detecting.

US Pat. No. 10,556,026

ULTRAVIOLET TRANSPARENT STRUCTURE FOR ULTRAVIOLET ILLUMINATION

Sensor Electronic Technol...

1. An apparatus, comprising:an ultraviolet transparent structure having an external surface, an internal surface, and side surfaces;
a set of ultraviolet radiation sources configured to generate ultraviolet radiation towards the external surface of the ultraviolet transparent structure, wherein the set of ultraviolet radiation sources are located away from an edge of the side surfaces of the ultraviolet transparent structure without directly contacting any edge of the side surfaces, wherein an emitting face of each of the ultraviolet radiation sources is at an angle or parallel to the internal surface and the external surface of the ultraviolet transparent structure, and wherein a portion of a surface of the emitting face of each of the ultraviolet radiation sources contacts only one of the internal surface or the external surface of the ultraviolet transparent structure;
a monitoring and control system to manage the ultraviolet radiation generated from the set of ultraviolet radiation sources by performing a method comprising:
monitoring a set of attributes relating to the external surface of the ultraviolet transparent structure; and
controlling, based on the monitoring, the ultraviolet radiation directed at the external surface of the ultraviolet transparent structure; and
wherein the ultraviolet transparent structure is integrated within a touch screen of an electronic device.

US Pat. No. 10,556,025

FIXED POSITION HYBRID GERMICIDAL IRRADIATION APPARATUS, METHOD, AND SYSTEM

1. A fixed position hybrid germicidal irradiation disinfection apparatus comprising:a rectangular housing configured to be coupled to a standard commercial lighting fixture fitting and electrical wiring;
a first plurality of emitters coupled to the rectangular housing, the first plurality of emitters operable to emit UV-C radiation at a wavelength of 265 nanometers;
a second plurality of emitters coupled to the rectangular housing, the second plurality of emitters operable to emit near-UV radiation at a wavelength of 405 nanometers;
a controller housed in the rectangular housing, the controller being operably engaged with the first plurality of emitters, the second plurality of emitters, and at least one visible light emitter; and
at least one ranging sensor coupled to the rectangular housing and operably configured to provide a ranging input to the controller, the controller being configured to calculate a virtual air gap adjustment parameter in response to the ranging input and to control an emission from the first plurality of emitters and the second plurality of emitters according to the virtual air gap adjustment parameter, and,
wherein the first plurality of emitters and the second plurality of emitters are configured to pulse emissions of UV-C radiation and near-UV radiation, respectively, in phase and out of phase.

US Pat. No. 10,556,023

SUBSTITUTED ORGANOFLUOROBORATES AS IMAGING AGENTS

THE UNIVERSITY OF BRITISH...

1. A positron emitting compound or salt thereof having a half-life with respect to solvolytic de-18F-fluoridation at physiological pH of about 1000 minutes or more, wherein the compound is of the formula (IV):
wherein:
B is boron;
each Y1 is independently selected from the group consisting of R1, 18F and 19F;
n=1 or 2;
Y2 is selected from the group consisting of R2, 18F and 19F;
R1 is a non-interfering substituent with regard to fluoridation of B;
R2 is a non-interfering substituent with regard to fluoridation of B;
at least one of (Y1)n and Y2 is 18F;
Q1 is —CR3R4R5 ;
each of R3, R4, and R5 is H, D, F, Cl, Br, I, CX3, —N+R15R16R17, —P+R18R19R20, —S+R21R22, —NR23R24, NHR23, a biomolecule, linking group optionally joined to a biomolecule, a group that is substituted with at least one substituent that is a biomolecule, forms a group that is substituted with at least one substituent that is a biomolecule, a linear or branched C1-C15 alkyl group, or a C3-C18 cycloalkyl group, wherein each of the C1-C15 alkyl group and the C3-C18 cycloalkyl group is unsubstituted or substituted and optionally includes at least one heteroatom interposed between two carbon atoms of the carbon chain of the group, wherein each of the at least one heteroatom is independently selected from the group consisting of O, S, N and P, each of the C1-C15 alkyl group and the C3-C18 cycloalkyl group is joined to the carbon atom of —CR3R4R5 through a carbon atom, and each X is the same or different and is F, Cl, Br, or I;
at least two of R3, R4 and R5 are independently F, Cl, Br, I, or CX3, or at least one of R3, R4 and R5 is —N+R15R16R17, —P+R18R19R20, —S+R21R22, or —NR23R24;
each of R15, R16 and R17 is independently H, D, a biomolecule, a linking group optionally joined to a biomolecule, a group that is substituted with at least one substituent that is a biomolecule, forms a group that is substituted with at least one substituent that is a biomolecule, a linear or branched C1-C15 alkyl group, or a C3-C18 cycloalkyl group, wherein each of the C1-C15 alkyl group and the C3-C18 cycloalkyl group is unsubstituted or substituted and optionally includes at least one heteroatom interposed between two carbon atoms of the carbon chain of the group, wherein each of the at least one heteroatom is independently selected from the group consisting of O, S, N and P, and each of the C1-C15 alkyl group and the C3-C18 cycloalkyl group is joined to the nitrogen atom of —N+R15R16R17 through a carbon atom, or R15 is absent and R16 and R17 are joined so that —N+R15R16R17 forms a positively charged nitrogen containing heterocyclic group which is substituted or unsubstituted;
each of R18, R19, and R20 is independently H, D, a biomolecule, a linking group optionally joined to a biomolecule, a group that is substituted with at least one substituent that is a biomolecule, forms a group that is substituted with at least one substituent that is a biomolecule, a linear or branched C1-C15 alkyl group, or a C3-C18 cycloalkyl group, wherein each of the C1-C15 alkyl group and the C3-C18 cycloalkyl group is unsubstituted or substituted and includes at least one heteroatom interposed between two carbon atoms of the carbon chain of the group, wherein each of the at least one heteroatom is independently selected from the group consisting of O, S, N and P, and each of the C1-C15 alkyl group and the C3-C18 cycloalkyl group is joined to the phosphorus atom of —P+R18R19 R20 through a carbon atom;
each of R21 and R22 is independently H, D, a biomolecule, a linking group optionally joined to a biomolecule, a group that is substituted with at least one substituent that is a biomolecule, forms a group that is substituted with at least one substituent that is a biomolecule, a linear or branched C1-C15 alkyl group, or a C3-C18 cycloalkyl group, wherein each of the C1-C15 alkyl group and the C3-C18 cycloalkyl group is unsubstituted or substituted and optionally includes at least one heteroatom interposed between two carbon atoms of the carbon chain of the group, wherein each of the at least one heteroatom is independently selected from the group consisting of O, S, N and P, and each of the C1-C15 alkyl group and the C3-C18 cycloalkyl group is joined to the sulfur atom of —S+R21R22 through a carbon atom; and
each of R23 and R24 is independently H, D, a biomolecule, a linking group optionally joined to a biomolecule, a group that is substituted with at least one substituent that is a biomolecule, forms a group that is substituted with at least one substituent that is a biomolecule, a linear or branched C1-C15 alkyl group, or a C3-C18 cycloalkyl group, wherein each of the C1-C15 alkyl group and the C3-C18 cycloalkyl group is unsubstituted or substituted and optionally includes at least one heteroatom interposed between two carbon atoms of the carbon chain of the group, wherein each of the at least one heteroatom is independently selected from the group consisting of O, S, N and P, and each of the C1-C15 alkyl group and the C3-C18cycloalkyl group is joined to the nitrogen atom of —NR23R24 through a carbon atom;
providing that Q1 is selected such that the pKa of Ha of an acid of the formula:

is less than or equal to about 2.8.

US Pat. No. 10,556,021

NANOCARRIERS FOR DRUG DELIVERY

THE REGENTS OF THE UNIVER...

1. A method of treating a disease, comprising administering to a subject in need of such treatment, a therapeutically effective amount of a nanocarrier comprising at least one conjugate having formula III:whereinA is a polyethylene glycol (PEG) polymer;
each X is a monomer unit comprising a diaminocarboxylic acid;
X? is a monomer unit selected from the group consisting of a diaminocarboxylic acid, an NH, and an O, optionally linked to a member selected from the group consisting of an optical probe, a radionuclide, a paramagnetic agent, a metal chelate and a drug; and
each R2 is independently an amphiphilic compound having both a hydrophilic face and a hydrophobic face, wherein each amphiphilic compound is independently selected from the group consisting of cholic acid, allocholic acid, pythocholic acid, avicholic acid, deoxycholic acid, and chenodeoxycholic acid;
wherein each conjugate self-assembles in an aqueous solvent to form the nanocarrier such that a hydrophobic pocket is formed in the interior of the nanocarrier by the orientation of the hydrophobic face of each amphiphilic compound towards each other, and wherein the PEG of each conjugate self-assembles on the exterior of the nanocarrier, and
wherein the nanocarrier further comprises a drug.

US Pat. No. 10,556,018

COMPOSITIONS AND METHODS FOR DELIVERY OF AGENTS

1. A method for delivering a therapeutic level of a protein of interest to a subject, the method comprising:administering to the subject at least two doses of lipid nanoparticles (LNPs) comprising an mRNA coding for the protein of interest, wherein the LNPs comprise an ionizable lipid, a helper lipid, a structural lipid, and a PEG-lipid,
wherein the PEG-lipid is a compound of Formula (V—OH):
or a pharmaceutically acceptable salt thereof, wherein:r is an integer between 1 and 100, inclusive; and
R5 is optionally substituted C10-40 alkyl; and
wherein said LNPs result in a reduced anti-PEG IgM response in the subject as compared to LNPs lacking a PEG-lipid of Formula (V—OH).

US Pat. No. 10,556,017

LIPID-BASED DRUG CARRIERS FOR RAPID PENETRATION THROUGH MUCUS LININGS

The Johns Hopkins Univers...

1. A method of administering a therapeutic, prophylactic, or diagnostic agent to cervicovaginal mucosa (CVM) comprising intravaginally administering mucus penetrating particles, wherein the mucus penetrating particles comprise:one or more PEG-conjugated phospholipids,
one or more lipids,
one or more stabilizers selected from the group consisting of cholesterol and ganglioside GM1, and
one or more therapeutic, prophylactic, and/or diagnostic agents,
wherein the concentration of the PEG-conjugated phospholipid is at least 10 mole percent of the total of the PEG-conjugated phospholipids, the lipids and the stabilizers,
wherein the stabilizer physically and/or chemically stabilizes the mucus penetrating particles and the concentration of the stabilizer is between about 10 mole percent and about 70 mole percent of the total of the PEG-conjugated phospholipids, the lipids, and the stabilizers,
wherein the mucus penetrating particles have an average diameter of between about 100 nm and about 500 nm, and
wherein at least 50% of the mucus penetrating particles are mobile in freshly collected, undiluted human CVM at 2 hours and at least 30% of the particles are mobile in freshly collected, undiluted human CVM at 15 hours.

US Pat. No. 10,556,013

COMPOSITIONS AND METHODS FOR INCREASING EFFICIENCY OF CARDIAC METABOLISM

IMBRIA PHARMACEUTICALS, I...

1. A compound represented by formula (X):

US Pat. No. 10,556,012

COMPOSITIONS AND METHODS FOR TOPICAL DELIVERY OF PROSTAGLANDINS TO SUBCUTANEOUS FAT

Topokine Therapeutics, In...

1. A composition comprising a compound of Formula (I):or a pharmaceutically acceptable salt thereof; wherein:each instance of independently represents a single bond or a double bond, which can be in the cis or trans configuration;
A is optionally substituted C1-10 alkylene, optionally substituted C2-10 alkenylene, or optionally substituted C2-10 alkynylene, wherein the alkylene, alkenylene, or alkynylene group is optionally interrupted by one or more —O— or —S— groups;
B is hydrogen, optionally substituted C3-7 carbocyclyl, optionally substituted 3-8-membered heterocyclyl, optionally substituted 5-14-membered heteroaryl, optionally substituted C6-10 aryl, optionally substituted C1-30 alkyl, optionally substituted C2-30 alkenyl, or optionally substituted C2-30 alkynyl;
X is —OR4, —SR4, or —N(R4)2, wherein each instance of R4 is independently hydrogen, optionally substituted C1-30 alkyl, optionally substituted C2-30 alkenyl, optionally substituted C2-30 alkynyl, —C(?O)R5, or —C(?O)OR5, wherein R5 is optionally substituted C1-30 alkyl, optionally substituted C2-30 alkenyl, or optionally substituted C2-30 alkynyl, or two R4 groups are joined to form an optionally substituted 3-8-membered heterocyclyl or optionally substituted 5-14-membered heteroaryl ring;
Z is ?O, ?S, or ?NRZ, wherein RZ is selected from hydrogen, an amino protecting group, —OH, substituted hydroxyl, optionally substituted C1-10 alkyl, optionally substituted C2-10 alkenyl, optionally substituted C2-10 alkynyl, optionally substituted C3-7 carbocyclyl, optionally substituted 3-8-membered heterocyclyl, optionally substituted C6-10 aryl, or optionally substituted 5-14-membered heteroaryl, or Z represents two hydrogen atoms; and
one of R1 and R2 is ?O, —OH, or a —O(CO)R6 group, and the other one is —OH or —O(CO)R6, or R1 is ?O and R2 is H, wherein R6 is an optionally substituted C1-20 alkyl, optionally substituted C2-20 alkenyl, optionally substituted C2-20 alkynyl, or —(CH2)mR7, wherein m is 0 or an integer of between 1-10, inclusive, and R7 is optionally substituted C3-7 carbocyclyl, optionally substituted 3-8-membered heterocyclyl, optionally substituted C6-10 aryl, or optionally substituted 5-14-membered heteroaryl;
and isopropyl myristate.

US Pat. No. 10,556,005

ADJUVANT COMPOSITION CONTAINING CITRULLINE

THE CHEMO-SERO-THERAPEUTI...

1. A process for enhancing the immunogenicity of an antigen comprising adding an adjuvant effective amount of citrulline to a vaccine comprising said antigen, wherein the adjuvant effective amount of citrulline ranges from 1 mg/mL to 50 mg/mL, wherein the citrulline is at least one member selected from the group consisting of L-citrulline, D-citrulline, L-thiocitrulline, L-thiohomocitrulline, S-methyl-L-thio-citrulline and S-ethyl-L-thiocitrulline.

US Pat. No. 10,556,003

TREATMENT OF INSECT BITE HYPERSENSITIVITY

1. A composition comprising:(a) a core particle with at least one first attachment site; and
(b) at least one antigen with at least one second attachment site, wherein said at least one antigen is:
(i) an equine Interleukin-5 antigen (eIL-5 antigen), wherein said eIL-5 antigen comprises a protein with the amino acid sequence selected from SEQ ID NO:1 or a protein with an amino acid sequence of at least 90% amino acid sequence identity with SEQ ID NO:1;
(ii) an equine Eotaxin antigen (eEotaxin antigen), wherein said eEotaxin antigen comprises a protein with the amino acid sequence selected from SEQ ID NO:6 or a protein with an amino acid sequence of at least 90% amino acid sequence identity with SEQ ID NO:6; or
(iii) an equine Interleukin-31 antigen (eIL-31 antigen), wherein said eIL-31 antigen comprises a protein with the amino acid sequence selected from SEQ ID NO:12 or a protein with an amino acid sequence of at least 90% amino acid sequence identity with SEQ ID NO:12;wherein (a) and (b) are linked through said at least one first and said at least one second attachment site via at least one non-peptide covalent bond.

US Pat. No. 10,555,997

ANTIGENS AND VACCINES DIRECTED AGAINST HUMAN ENTEROVIRUSES

SENTINEXT THERAPEUTICS Sd...

1. An expression cassette comprising a promoter operably linked to a nucleic acid sequence encoding a human enterovirus C P1 polypeptide, wherein the nucleic acid sequence encoding the human enterovirus C P1 polypeptide is operably linked to a nucleic acid sequence encoding a human enterovirus C Internal Ribosome Entry Site (IRES), wherein the nucleic acid sequence encoding the IRES is operably linked to a nucleic acid sequence encoding a human enterovirus C 3CD protease, wherein the human enterovirus C 3CD protease is under the translational control of the IRES.

US Pat. No. 10,555,995

PORCINE PESTVIRUS, VACCINES, AND ASSAYS

Kansas State University R...

1. An immunogenic composition to induce an immune response against porcine pestivirus infection in a pig, said composition comprising a therapeutically-effective amount of atypical porcine pestivirus (APPV) antigenic agents dispersed in a pharmaceutically-acceptable carrier, said APPV antigenic agents being selected from the group consisting of: (a) isolated whole virus having an mRNA complementary coding sequence according to Genbank accession no. KR011347.1 (SEQ ID NO:1) that is a live attenuated or inactivated virus, (b) functional fragments of said isolated whole virus selected from the group consisting of virus subunits, purified antigens, surface proteins, recombinant viral proteins and combinations thereof, and (c) combinations of the foregoing, wherein the functional fragments and combinations thereof further comprise an adjuvant.

US Pat. No. 10,555,985

PHARMACEUTICAL COMPOSITION COMPRISING REFINED INDIGO NATURALIS EXTRACTS AND THE USE THEREOF

Galderma S.A., Cham (CH)...

1. A method of treating a disease or condition selected from the group consisting of psoriasis, an inflammatory skin condition, onychomycosis, skin cancer, abnormal keratinization induced disease, skin aging, and pustular dermatosis, comprising administering to a subject in need thereof a pharmaceutical composition comprising a solid extract of Indigo Naturalis, wherein the solid extract comprises, relative to the total weight of the extract:65% to 90% (w/w) indirubin;
0.1-15% (w/w) indigo; and
0.01-5% (w/w) tryptanthrin,
wherein the pharmaceutical composition comprises 0.002% to 0.077% (w/w) of the solid extract relative to the total weight of the pharmaceutical composition.

US Pat. No. 10,555,974

METHODS FOR THE TREATMENT OF ERECTILE DYSFUNCTION BY HUMAN BIRTH TISSUE MATERIAL COMPOSITION

BioDlogics, LLC, Cordova...

1. A composition for treating erectile dysfunction comprising:a human birth tissue material composition for topical application or introduction onto or into a penis affected by erectile dysfunction, the human birth tissue material composition comprising a therapeutically effective amount of a one or more components of a placental organ selected from the group consisting of morselized placental globe, morselized umbilical cord, umbilical cord blood, morselized chorionic membrane, morselized amniotic membrane, Wharton's jelly, amniotic fluid, and other placental gelatins, cells, and morselized extracellular material,
wherein the morselized placental component(s) is/are homogenized with a tissue suspension solution, the tissue suspension solution comprising human albumin 25% solution and dimethyl sulfoxide, and
wherein the composition is suitable for restoration of erectile function.

US Pat. No. 10,555,968

PERFORMANCE ENHANCING COMPOSITION AND USE THEREOF

1. A daily nutritional supplement or a nutritional food composition comprising a botanical source of inorganic nitrate and a nitrite salt, wherein the nitrate from said botanical nitrate source and the amount of said nitrite salt is in a molar ratio of about 5:1 to 100:1, wherein one dose of the composition provides said nitrite salt in an amount of about 0.001-10 mmol/kg bodyweight.

US Pat. No. 10,555,965

ENVIRONMENT-RESPONSIVE HYALURONIC ACID NANOPARTICLES

Industry-University Coope...

1. A hyaluronic acid complex comprising a hyaluronic acid-boronic acid repeating unit in which a boronic acid compound is bound to a carboxyl group of a repeating unit represented by the following Formula 1
wherein the boronic acid compound in the hyaluronic acid-boronic acid repeating unit is bound to a hyaluronic acid repeating unit via an amide bond by means of a diamine compound serving as a linker, and
wherein the diamide compound is ethylenediamine, butylenediamine, hexamethylenediamine, pentaethylenehexamine, or 1,5-diamino-2-methylpentane.

US Pat. No. 10,555,964

COMPOSITION AND METHOD FOR PROMOTING REDUCTION OF HEAT STRESS IN ANIMALS

OmniGen Research, L.L.C.,...

1. A method, comprising:identifying a bovine that is experiencing a heat effect; and
administering to the bovine a composition comprising between 1.0 wt % and 5.0 wt % ?-glucans, between 15 wt % and 40 wt % silica, between 50 wt % and 81 wt % mineral clay, between 1 wt % and 8.0 wt % mannan, and endoglucanohydrolase, wherein the composition is administered for an effective period of time to (a) increase feed intake or (b) decrease water consumption, respiration rate, and/or rectal temperature, or (c) any combination thereof, when compared to a feed intake, water consumption, respiration rate, and/or rectal temperature of a bovine that is experiencing a heat effect and is not administered the composition.

US Pat. No. 10,555,960

USE OF AN AMINOGLYCOSIDE FOR NONSENSE MUTATION SUPPRESSION AND THE TREATMENT OF DISEASE

PTC Therapeutics, Inc., ...

1. A method for treating a disease caused by premature translation termination, a nonsense mutation or a premature stop codon, for the purpose of minimizing the spread or worsening of said disease, comprising administering to a patient having said disease an effective amount of a compound having the structure of Compound 1:
having the name (2R,3S,4R,5R,6S)-5-amino-6-(((1R,2S,3S,4R,6S)-4,6-diamino-3-(((2R,3R,4R,5R)-3,5-dihydroxy-5-methyl-4-(methylamino)tetrahydro-2H-pyran-2-yl)oxy)-2-hydroxycyclohexyl)oxy)-2-(hydroxymethyl)tetrahydro-2H-pyran-3,4-diol, or a pharmaceutically acceptable salt or hydrate thereof; wherein, the compound is a purified stereoisomer.

US Pat. No. 10,555,958

COMBINATION TREATMENT OF SGLT2 INHIBITORS AND DOPAMINE AGONISTS FOR PREVENTING METABOLIC DISORDERS IN EQUINE ANIMALS

1. A method for treating a metabolic disorder in an equine in need of such treatment comprising administering to the equine an effective amount of a medicament comprising one or more SGLT2 inhibitors, pharmaceutically acceptable forms or salts thereof in combination with one or more dopamine receptor agonists, pharmaceutically acceptable forms or salts thereof, wherein:the one or more SGLT2 inhibitors comprises 1-cyano-2-(4-cyclopropyl-benzyl)-4-(?-D-glucopyranos-1-yl)-benzene, represented by the formula:
andthe one or more dopamine receptor agonists comprises (8?)-8-[(methylthio)methyl]-6-propylergoline (pergolide), represented by the formula:

US Pat. No. 10,555,957

METHODS AND COMPOSITIONS FOR ENRICHING DHA LEVELS IN THE BRAIN

The Board of Trustees of ...

1. A compound according to Formula 1
wherein R1 is —OH, and wherein R2 is EPA, or
wherein R1 is eicosapentaenoic acid (EPA), and wherein R2 is —OH.

US Pat. No. 10,555,955

TRIMEGESTONE (TMG) FOR TREATMENT OF PRETERM BIRTH

Dignity Health, Phoenix,...

1. A method of extending pregnancy term in a subject in need thereof, comprising:providing a quantity of a composition comprising trimegestone or a salt thereof and one or more solubilizing factors selected from sesame oil, corn oil, olive oil, coconut oil, flaxseed oil, argan oil, and castor oil; and
administering the quantity of the composition to the subject in need thereof, wherein the composition is administered through transdermal delivery; wherein the effective dosage range of the trimegestone or salt thereof is between 0.05 mg and 100 mg; and wherein the pregnancy term is extended by an additional one day to 22 weeks.

US Pat. No. 10,555,954

HAZARDOUS AGENT INJECTION SYSTEM

Antares Pharma, Inc., Ew...

1. A hazardous agent injection system comprising:a hazardous agent; and
a powered injector comprising:
a housing;
a container containing the hazardous agent disposed within the housing;
an injection outlet member fluidly coupled with the container and configured to deliver the hazardous agent to a patient subcutaneously;
a firing mechanism operatively coupled to the container and configured to expel the hazardous agent from the container through the injection outlet member for injecting the hazardous agent;
an energy source coupled to the firing mechanism and configured to power the firing mechanism;
a trigger mechanism coupled to the firing mechanism and configured to move radially outwardly to activate the firing mechanism;
a latching portion coupling the trigger mechanism to the firing mechanism, the latching portion configured to prevent activation of the firing mechanism, and
a safety member removably coupled to the housing, the safety member configured to prevent the trigger mechanism from moving radially outward and configured to prevent movement of the latching portion to prevent the firing mechanism from expelling the hazardous agent from the container.

US Pat. No. 10,555,950

BILE ACID RECYCLING INHIBITORS FOR TREATMENT OF OBESITY AND DIABETES

SATIOGEN PHARMACEUTICALS,...

1. A method of treating diabetes comprising administering to the distal ileum, the colon, or the rectum of a diabetic individual, a single pharmaceutical composition consisting of a therapeutically effective amount of an Apical Sodium-dependent Bile Transporter Inhibitor (ASBTI) and one or more pharmaceutical carriers, wherein the ASBTI isor a pharmaceutically acceptable salt thereof.

US Pat. No. 10,555,949

PYRROLOPYRIMIDINE COMPOUNDS USED AS TLR7 AGONIST

CHIA TAI TIANQING PHARMAC...

1. A compound of formula (I) or a pharmaceutically acceptable salt thereofwhereinL1 and L2 are each independently selected from the group consisting of —O— and —CH2—;
R1 is selected from the group consisting of C1-10 alkyl, wherein the above C1-10 alkyl is optionally substituted by one or more R4;
R2 is selected from the group consisting of hydrogen, cyano and —CONH2, wherein the above —CONH2 is optionally substituted by one or more R4;
B is selected from the group consisting of C3-10 cyclohydrocarbyl, 3-10 membered heterocyclohydrocarbyl, aryl and heteroaryl;
L3 is selected from the group consisting of C0-6 alkylene, wherein the above C0-6 alkylene is optionally substituted by one or more R4;
R3 is selected from the group consisting of hydrogen, amino, C1-10 alkyl, C3-10 cyclohydrocarbyl, 3-10 membered heterocyclohydrocarbyl, aryl and heteroaryl, wherein the above amino, C1-10 alkyl, C3-10 cyclohydrocarbyl, 3-10 membered heterocyclohydrocarbyl, aryl and heteroaryl are optionally substituted by one or more R4; or
R3 and L3 together with the adjacent atom at the ring B form a saturated or unsaturated 5-8 membered ring, wherein the 5-8 membered ring is optionally substituted by one or more R4;
n is 0, 1, 2, 3, 4 or 5;
R4 is selected from the group consisting of halogen, —R, —OR and ?O;
R is independently selected from the group consisting of H and C1-8 alkyl; and
when L1 is —CH2—, R3 is not H.

US Pat. No. 10,555,948

NANOCARRIERS AND THEIR PROCESSING FOR DIAGNOSTICS AND THERAPEUTICS

Rhode Island Hospital, P...

1. A method of treating joint disease comprising administration to a subject of an effective amount of a nanopiece, wherein said nanopiece comprises i) a compound of Formula I or Formula II or a combination thereof, and ii) a nucleic acid:
wherein, X is CH or N;
R2 is hydrogen or a linker group;
Y is absent when R2 is hydrogen or is an amino acid side chain, amino acid or polypeptide; and
R1 is hydrogen or aliphatic, wherein the nanopiece has a size in at least one dimension between 0.1 nm and 150 nm,
wherein a ratio of the compound to nucleic acid ranges from 4.4 to 30 ?g compound per to 0.1 nmol of the nucleic acid;
wherein the nanopiece is positively charged at pH 7-7.5.

US Pat. No. 10,555,946

3-(SUBSTITUTED-4-OXOQUINAZOLIN-3(4H)-YL)-3-DEUTERO-PIPERIDINE-2,6-DIONE DERIVATIVES AND COMPOSITIONS COMPRISING AND METHODS OF USING THE SAME

DeuteRx, LLC, Andover, M...

1. A method for treating a disorder selected from the group consisting of multiple myeloma, leprosy, and non-Hodgkin's lymphoma, the method comprising administering to a patient in need thereof a therapeutically effective amount of a deuterium-enriched compound of formula I to treat the disorder, wherein formula I is:
or a pharmaceutically acceptable salt, solvate, or stereoisomer thereof, wherein:
Z is H or D, provided that the abundance of deuterium in Z is at least 30%;
R1, R2, R3, R4, R5, and R10 are independently selected from H and D;
R6 is selected from: H; D; —(CH2)nOH; phenyl; —O(C1-C6)alkyl; and (C1-C6)alkyl optionally substituted with one or more halo;
R7, R8, and R9 are independently selected from: H; D; halo; —(CH2)nOH; (C1-C6)alkyl optionally substituted with one or more halo; (C1-C6)alkoxy optionally substituted with one or more halo; and —(CH2)nNHRa;
alternatively, two of R7, R8, R9, and R10 are taken together with the atoms to which they are attached to form a 5-6 membered ring optionally substituted with one or more groups independently selected from halo; (C1-C6)alkyl optionally substituted with one or more halo; and (C1-C6)alkoxy optionally substituted with one or more halo;
Ra is selected from: H; D; (C1-C6)alkyl optionally substituted with one or more halo; —(CH2)n-(6 to 10 membered aryl); —C(O)(CH2)n-(6 to 10 membered aryl); —C(O)(CH2)n-(6 to 10 membered heteroaryl); —C(O)(C1-C8)alkyl optionally substituted with one or more halo; —C(O)(CH2)n—(C3-C10-cycloalkyl); —C(O)(CH2)n—NRbRc, —C(O)(CH2)n—O—(C1-C6)alkyl; and —C(O)(CH2)n—O—(CH2)n-(6 to 10 membered aryl); wherein the aryl and heteroaryl are optionally substituted with one or more groups independently selected from: halo; —SCF3; (C1-C6)alkyl optionally substituted with one or more halo; and (C1-C6)alkoxy optionally substituted with one or more halo;
Rb and Rc are each independently selected from: H; D; (C1-C6)alkyl optionally substituted with one or more halo; (C1-C6)alkoxy optionally substituted with one or more halo; and 6 to 10 membered aryl; the aryl being optionally substituted with one or more groups independently selected from: halo; (C1-C6)alkyl optionally substituted with one or more halo; and (C1-C6)alkoxy optionally substituted with one or more halo;
n is independently selected from 0, 1, and 2; and
a hydrogen atom present in any substituent is optionally replaced by D.

US Pat. No. 10,555,945

COMPOUNDS

Autifony Therapeutics Lim...

1. A method for the treatment or prophylaxis of anxiety disorders, which comprises administering to a subject in need thereof a compound of formula (I):
wherein:
W is CRaRb or 0;
when W is CRaRb then Z is CH2;
when W is O then Z is CF2;
Ra and Rb are CH3 or taken together form a C3 spiro cycloalkyl;
wherein, when W is CRaRb, Z is CH2 and Ra and Rb are CH3:
Ring A is:

 and Ring B is:

or
Ring A is:

 and Ring B is:

wherein, when W is CRaRb, Z is CH2 and Ra and Rb taken together form a C3 spiro cycloalkyl:
Ring A is:

 and
Ring B is:

 and
wherein, when W is O and Z is CF2:
Ring A is:

 and Ring B is:

or a pharmaceutically acceptable salt and/or solvate thereof.

US Pat. No. 10,555,944

SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS

Eli Lilly and Company, I...

1. A compound of the Formula I:and pharmaceutically acceptable salts thereof, wherein:X1, X2, X3 and X4 are independently CH, CF or N, wherein zero, one or two of X1, X2, X3 and X4 is N;
A is H, CN, Cl, CH3—, CH3CH2—, cyclopropyl, —CH2CN or —CH(CN)CH3;
B is
(a) hydrogen,
(b) C1-C6 alkyl optionally substituted with 1-3 fluoros,
(c) hydroxyC2-C6 alkyl- wherein the alkyl portion is optionally substituted with a C3-C6 cycloalkylidene ring,
(d) dihydroxyC3-C6 alkyl-, wherein the alkyl portion is optionally substituted with a C3-C6 cycloalkylidene ring,
(e) (C1-C6 alkoxy)C1-C6 alkyl- optionally substituted with 1-3 fluoros,
(f) (R1R2N)C1-C6 alkyl- wherein R1 and R2 are independently H or C1-C6 alkyl (optionally substituted with 1-3 fluoros);
(g) hetAr1C1-C3 alkyl-, wherein hetAr1 is a 5-6 membered heteroaryl ring having 1-3 ring heteroatoms independently selected from N, O and S and is optionally substituted with one or more independently selected C1-C6 alkyl substituents;
(h) (C3-C6 cycloalkyl)C1-C3 alkyl-,
(i) (hetCyca)C1-C3 alkyl-, or
(j) hetCyca;hetCyca is a 4-6 membered heterocyclic ring having 1-2 ring heteroatoms independently selected from N and 0 and is optionally substituted with OH, C1-C6 alkyl (optionally substituted with 1-3 fluoros) or hydroxyC1-C6 alkyl-;Ring D is
wherein the wavy line indicates the point of attachment of Ring D to the ring comprising X1, X2, X3 and X4, and the asterisk indicates the point of attachment to E;E is
(a) hydrogen,
(b) C1-C6 alkyl optionally substituted with 1-3 fluoros,
(d) (C1-C6 alkyl)C(?O)— wherein said alkyl portion is optionally substituted with 1-3 fluoros or with a RgRhN— substituent wherein Rg and Rh are independently H or C1-C6 alkyl,
(f) (C1-C6 alkoxy)C(?O),
(l) hetAr2C(?O)—,
(o) R3R4NC(?O)—,
(s) Ar1SO2—,
(t) hetAr2SO2—,
(v) Ar1C(?O)—,
(cc) hetAr2, or
(dd) C3-C6 cycloalkyl;
R3 is H or C1-C6 alkyl; and
R4 is C1-C6 alkyl.

US Pat. No. 10,555,943

TEMOZOLOMIDE POWDER FORMULATION

AMPLIPHARM PHARMACEUTICAL...

1. A method of administering temozolomide comprising orally administering a temozolomide powder with a separate drink of water, wherein the temozolomide powder is readily dispersible in an aqueous solution suitable for oral administration and the temozolomide powder comprises:(a) granules of temozolomide and one or more emulsifiers, the granules coated with a pH dependent coating composition comprising a pH dependent coating material; and
(b) a dispersant,
wherein at least 80% of the temozolomide powder dissolves within 30 minutes when tested according to USP I dissolution test (basket) in 900 mL of 0.1 N HCl at 37° C.±0.5° C. and a speed of 100 rpm.

US Pat. No. 10,555,941

ALKYL LINKED QUINOLINYL MODULATORS OF ROR?T

Janssen Pharmaceutica NV,...

1. A method for treating or ameliorating a ROR?t mediated inflammatory syndrome, disorder or disease, wherein the disease is selected from the group consisting of: inflammatory bowel diseases, rheumatoid arthritis, psoriasis, chronic obstructive pulmonary disorder, psoriatic arthritis, ankylosing spondylitis, neutrophilic asthma, steroid resistant asthma, multiple sclerosis, and systemic lupus erythematosus, comprising administering to a subject in need thereof an effective amount of a compound of Formula I:wherein:R1 is azetidinyl, imidazolyl, pyrimidinyl, triazolyl, tetrahydropyranyl, thiazolyl, pyridyl, piperidinyl, phenyl, oxazolyl, or isoxazolyl; wherein said piperidinyl, pyridyl, imidazolyl, and phenyl are optionally substituted with SO2CH3, C(O)CH3, CH3, CF3, Cl, F, —CN, OCH3, or N(CH3)2; and optionally substituted with up to one additional group independently selected from Cl, OCH3, and CH3; and wherein said triazolyl, oxazolyl, isoxazolyl, and thiazolyl are optionally substituted with one or two CH3 groups; and wherein said azetidinyl is optionally substituted with CO2C(CH3)3, or C(O)CH3;
R2 is C(1-6)alkyl, cyclopropyl, or alkynyl;
R3 is OH;
R4 is H;
R5 is Cl, —CN, CF3, CH3, OH, N(CH3)OCH3, N(CH3)2, azetidin-1-yl, or OCH3;
R6 is pyridyl or phenyl, wherein said phenyl is optionally substituted with Cl, F, CF3, SO2CH3, or OCF3; or R6 is —O-phenyl, wherein said —O-phenyl is optionally substituted with Cl, F, or —CN; or R6 is —CH2R6?, wherein R6? is pyridyl, or phenyl, wherein said pyridyl or phenyl is optionally substituted with pyrazol-1-yl, 1,2,4-triazol-1-yl, CF3, OCH3, SO2CH3, Cl, F, or —CN;
R7 is Cl, —CN, C(1-4)alkyl, OC(1-2)alkyl, or NA1A2;
A1 is C(1-2)alkyl;
A2 is C(1-2)alkyl, CH2CH2OCH3, or OCH3; or A1 and A2 may be taken together with their attached nitrogen to form a ring selected from the group consisting of:

Ra is OH, OCH3, F;
R8 is H;
R9 is H;and pharmaceutically acceptable salts thereof.

US Pat. No. 10,555,935

2-SPIRO-5- AND 6-HYDROXAMIC ACID INDANES AS HDAC INHIBITORS

FORMA Therapeutics, Inc.,...

1. A compound of the Formula I:or a pharmaceutically acceptable salt thereof, wherein:X1, X2, X3, X4, X5, and X6 are each independently, at each occurrence, —CR1R2— or —C(O)—;
Y1, Y2, Y3, and Y4 are each independently, at each occurrence, N or CR1, wherein —C(O)NHOH is attached at Y2 or Y3, and Y2 or Y3 is a carbon atom when attached to —C(O)NHOH;
L is a bond, —(CR1R2)p—, —C(O)NR3—, —S(O)2—, —S(O)2NR3—,—S(O)—, —S(O)NR3—, —C(O)(CR1R2)pO—, or —C(O)(CR1R2)p—;
R is —H, —C1-C6alkyl, —C2-C6alkenyl, —C4-C8cycloalkenyl, —C2-C6alkynyl, —C3-C8cycloallkyl, —C5-C12spirocycloalkyl, heterocyclyl, spiroheterocyclyl, aryl, or heteroaryl containing 1-5 heteroatoms selected from the group consisting of N, S, P, or O, wherein each alkyl, alkenyl, cycloalkenyl, alkynyl, cycloalkyl, spirocycloalkyl, heterocyclyl, spiroheterocyclyl, aryl, or heteroaryl is optionally substituted with one or more —OH, halogen, oxo, —NO2, —CN, —R1, —R2, —SR3, —OR3, —NHR3, —NR3R4, —S(O)2NR3R4, —S(O)2R1, —C(O)R1, —CO2R1, —NR3S(O)2R1, —S(O)R1, —S(O)NR3R4, —NR3S(O)R1, heterocyclyl, aryl, or heteroaryl;
R1 and R2 are independently, at each occurrence, —H, —R3, —R4, —C1-C6alkyl, —C2-C6alkenyl, —C4-C8cycloalkenyl, —C2-C6alkynyl, —C3-C8cycloalkyl, heterocyclyl, aryl, heteroaryl containing 1-5 heteroatoms selected from the group consisting of N, S, P and O, —OH, halogen, —NO2, —CN, —NH(C1-C6alkyl), —N(C1-C6alkyl)2, —S(O)2N(C1-C6alkyl)2, —N(C1-C6alkyl)S(O)2R5, —S(O)2(C1-C6alkyl), —(C1-C6alkyl)S(O)2R5, —C(O)C1-C6alkyl, —CO2C1-C6alkyl, —N(C1-C6alkyl)S(O)2(C1-C6alkyl), or —(CHR5)pNR3R4, wherein each alkyl, alkenyl, cycloalkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl is optionally substituted with one or more —OH, halogen, —NO2, oxo, —CN, —R5, —OR3, —NHR3, —NR3R4, —S(O)2N(R3)2, —S(O)2R5, —C(O)R5, —CO2R5, —NR3S(O)2R5, —S(O)R5, —S(O)NR3R4, —NR3S(O)R5, heterocyclyl, aryl, or heteroaryl;
or R1 and R2, when on the same atom, can combine with the carbon atom to which they are attached to form a cycloalkyl, hetercyclyl, spirocycloalkyl, spiroheterocyclyl, or spirocycloalkenyl;
or R1 and R2, when on adjacent or non-adjacent atoms, can combine to form a hetercyclyl, cycloalkyl, aryl, heteroaryl containing 1-5 heteroatoms selected from the group consisting of N, S, P and O, or cycloalkenyl;
R3 and R4 are independently, at each occurrence, —H, —C1-C6alkyl, —C2-C6alkenyl, —C4-C8cycloalkenyl, —C2-C6alkyl, —C3-C8cycloalkyl, heterocyclyl, aryl, heteroaryl containing 1-5 heteroatoms selected from N, S, P, and O, —S(O)2N(C1-C6alkyl)2, —S(O)2(C1-C6alkyl), —(C1-C6alkyl)S(O)2R5, —C(O)C1-C6alkyl, —CO2C1-C6alkyl, or —(CHR5)pN(C1-C6alkyl)2, wherein each alkyl, alkenyl, cycloalkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, and heteroaryl is optionally substituted with one or more substituents selected from —OH, halogen, —NO2, oxo, —CN, —R5, —O(C1-C6)alkyl, —NH(C1-C6alkyl), —N(C1-C6alkyl)2, —S(O)2N(C1-C6alkyl)2, —S(O)2NH(C1-C6alkyl), —C(O)C1-C6alkyl, —CO2C1-C6alkyl, —N(C1-C6alkyl)S(O)2(C1-C6alkyl), —S(O)R5, —S(O)N(C1-C6alkyl)2, —N(C1-C6alkyl)S(O)R5, heterocyclyl, aryl, or heteroaryl;
R5 is independently, at each occurrence, —H, —C1-C6alkyl, —C2-C6alkenyl, —C4-C8cycloalkenyl, —C2-C6alkynyl, —C3-C8cycloalkyl, heterocyclyl, aryl, heteroaryl containing 1-5 heteroatoms selected from N, S, P and O, —OH, halogen, —NO2, —CN, —NH(C1-C6alkyl), —N(C1-C6alkyl)2, —S(O)2NH(C1-C6alkyl), —S(O)2N(C1-C6alkyl)2, —S(O)2(C1-C6alkyl), —C(O)C1-C6alkyl, —CO2C1-C6alkyl, —N(C1-C6alkyl)S(O)2(C1-C6alkyl), —S(O)(C1-C6alkyl), —S(O)N(C1-C6allkyl)2, —N(C1-C6alkyl)S(O)(C1-C6alkyl), or —(CH2)pN(C1-C6alkyl)2;
p is 0, 1, 2, 3, 4, 5, or 6;
n is 0 or 1;
m is 0 or 1; and
wherein the sum m+n=1.

US Pat. No. 10,555,934

ALPHA-AMINO ESTERS OF HYDROXYPROPYLTHIAZOLIDINE CARBOXAMIDE DERIVATIVE AND SALT FORM, CRYSTAL POLYMORPH THEREOF

ObsEva S.A., Plan-les-Ou...

1. A method of treating preterm labor in a human patient in need thereof, the method comprising administering to the patient a therapeutically effective amount of a compound represented by formula (I),or a pharmaceutically acceptable salt thereof, and wherein the patient is further administered nifedipine.

US Pat. No. 10,555,930

COMPLEX OF A GLUCOPYRANOSYL DERIVATIVE AND PREPARATION METHOD AND USE THEREOF

1. A complex having Formula (IA):or a hydrate thereof, wherein the complex comprises a compound having Formula (I-n) and L-pyroglutamic acid at a mole ratio of 1:1,wherein the complex is in a crystalline form, and wherein the crystalline form has an X-ray powder diffraction pattern:comprising peaks at scattering angles (2?) of 3.61°±0.2°, 13.35°±0.2°, 17.84°±0.2°, 18.22°±0.2°, 19.92°±0.2° and 21.43°±0.2°; or
comprising peaks at scattering angles (2?) of 3.61°±0.2°, 7.14°±0.2°, 13.35°±0.2°, 17.84°±0.2°, 18.22°±0.2°, 19.92°±0.2°, 21.43°±0.2° and 22.70°±0.2°; or
comprising peaks at scattering angles (2?) of 3.61°±0.2°, 7.14°±0.2°, 11.44°±0.2°, 11.84°±0.2°, 13.35°±0.2°, 16.33°±0.2°, 16.71°±0.2°, 17.16°±0.2°, 17.84°±0.2°, 18.22°±0.2°, 19.92°±0.2°, 21.43°±0.2°, 22.70°±0.2° and 22.96°±0.2°; or
comprising peaks at scattering angles (2?) of 3.61°±0.2°, 7.14°±0.2°, 11.44°±0.2°, 11.84°±0.2°, 13.35°±0.2°, 16.33°±0.2°, 16.71°±0.2°, 17.16°±0.2°, 17.84°±0.2°, 18.22°±0.2°, 18.52°±0.2°, 19.92°±0.2°, 21.43°±0.2°, 21.74°±0.2°, 22.70°±0.2°, 22.96°±0.2°, 23.75°±0.2°, 24.31°±0.2°, 25.07°±0.2°, 25.84°±0.2°, 26.50°±0.2°, 27.75°±0.2°, 28.61°±0.2°, 29.25°±0.2°, 29.44°±0.2°, 30.17°±0.2°, 30.99°±0.2°, 31.59°±0.2°, 32.40°±0.2°, 32.81°±0.2°, 34.32°±0.2°, 34.79°±0.2°, 35.43°±0.2°, 36.09°±0.2° and 38.03°±0.2°; orsubstantially the same as shown in FIG. 2.

US Pat. No. 10,555,929

METHODS FOR THE TREATMENT OF NONALCOHOLIC FATTY LIVER DISEASE AND/OR LIPODYSTROPHY

Coherus Biosciences, Inc....

1. A method of treating nonalcoholic steatohepatitis (NASH) comprising administering to a subject in need thereof a therapeutically effective amount of a compound of formula (I):
or a pharmaceutically acceptable salt thereof.

US Pat. No. 10,555,923

METHOD FOR TREATING PAROXYSMAL NOCTURNAL HEMOGLOBINURIA

Enzychem Lifesciences Cor...

1. A method for treating paroxysmal nocturnal hemoglobinuria (PNH), comprising administering to a patient in need thereof an effective amount of a compound of Formula 1:
wherein R1 and R2 are independently a fatty acid residue of 14 to 22 carbon atoms.

US Pat. No. 10,555,922

METHOD OF TREATING A DOPAMINE RELATED DISORDER IN A SUBJECT BY ADMINISTERING LEVODOPA, IN COMBINATION WITH A DOPAMINE DECARBOXYLASE INHIBITOR AND A CATECHOL-O-METHYLTRANSFERASE INHIBITOR

LobSor Pharmaceuticals Ak...

1. A method of treating a dopamine related disorder in a subject who has received prior therapy with an intestinal gel that delivers levodopa in combination with a dopamine decarboxylase inhibitor (DDI) according to a reference regimen optimized for the subject, so that the subject received an optimized dose of the levodopa and DDI over a selected time period, the method comprising a step of:administering to the subject a combination therapy with levodopa in combination with both a DDI and a catechol-O-methyltransferase (COMT) inhibitor, so that, over the selected time period one or more of:
(i) the administered dose of levodopa is lower than the prior optimized dose;
(ii) the administered dose of DDI is lower than the prior optimized dose;
(iii) the dosing of levodopa is less frequent than in the reference regimen; or
(iv) the dosing of DDI is less frequent than in the reference regimen,wherein the DDI is selected from the group consisting of carbidopa, benzerazide, and combinations thereof, andwherein at least the levodopa and the DDI are administered via an intestinal gel.

US Pat. No. 10,555,920

NECROSIS INHIBITORS

National Institute of Bio...

1. An amide compound that is an inhibitor of cellular necrosis and/or human receptor interacting protein 1 kinase (RIP1), of formula:
wherein:
R1 is (a) substituted or unsubstituted phenyl;
(b) substituted or unsubstituted 2-, 3- or 4-pyridine;
(c) substituted or unsubstituted naphthyl or 3-azanaphthyl;
(d) substituted or unsubstituted 0-3 heteroatom cyclohexyl, cyclopentyl; or
(e) substituted or unsubstituted 0-3 heteroatom cyclopentene or cyclopentadiene;
R2 is substituted or unsubstituted aziridine, azetidine, pyrrolidine, piperidine, oxazridine, oxazetidine, oxazolidine, oxazinane, thiaziridine, thiazetidine, thiazolidine, thiazinane, diaziridine, diazetidine, diazolidine (pyrazolidine), diazinane; or
R2 is substituted or unsubstituted pyrrole, dihydropyrrole, pyridine, dihydropyridine, tetrahydropyridine, azole, pyrimidine, oxazine, thiazine, triazine, ozadiazine, thiadiazine; and
R3 is substituted or unsubstituted, 0-3 heteroatom C1-C9 alkyl, alkenyl, or alkynyl; or
a corresponding sulfonamide of the amide compound, or
a pharmaceutically acceptable salt, hydrate or stereoisomer the compound or corresponding sulfonamide.

US Pat. No. 10,555,916

NMDAR ANTAGONIST FOR THE TREATMENT OF PERVASIVE DEVELOPMENT DISORDERS

CASE WESTERN RESERVE UNIV...

1. A method of treating Rett syndrome in a subject in need thereof, the method comprising administering to said subject a sub-anesthetic bolus injection of ketamine at a dosage of 1-20 mg/kg.

US Pat. No. 10,555,905

QUICK RELEASE SOLENOID ASSEMBLY

Graco Minnesota Inc., Mi...

1. A fluid dispensing system comprising:a manifold including a fluid outlet, a first tube opening extending into a first side of the manifold, and a second tube opening extending into the first side of the manifold; and a mount opening extending into a second side of the manifold and intersecting with the first tube opening;
a dispensing module fluidly connected to the manifold and configured to receive a liquid adhesive from a fluid outlet of the manifold and to dispense the liquid adhesive;
a solenoid assembly mounted to the manifold by a first air tube and a second air tube, wherein the solenoid assembly is configured to selectively direct air to the dispensing module to actuate the dispensing module between an open position and a closed position;
wherein the first air tube extends into the first tube opening and the second air tube extends into the second tube opening;
wherein a quick release mechanism is mounted in the mount opening, engages the first air tube, and does not engage the second air tube, such that the quick release mechanism is configured to directly secure the first air tube to the manifold and to indirectly secure the solenoid assembly and second air tube to the manifold by the first air tube.

US Pat. No. 10,555,887

STERILE LIQUID COMPOSITION FOR FILLING WRINKLES

1. A sterile liquid composition to inject into or through the skin and/or the lips suitable for filling wrinkles, comprising, in a physiologically acceptable medium, an antiwrinkle active agent, a photo-crosslinkable compound, wherein the photo-crosslinkable compound is a polyvinyl alcohol partly functionalized with one or more hydroxyl groups and one or more groups of formula (III):

US Pat. No. 10,555,884

2-PYRIDINOL-N-OXIDE DEODORANT AND ANTIPERSPIRANT COMPOSITIONS

1. A deodorant stick comprising:a. a substituted or unsubstituted 2-pyridinol-N-oxide material; and
b. a chelant, wherein the ratio of chelant to the substituted or unsubstituted 2-pyridinol-N-oxide material is at least about 4:1.

US Pat. No. 10,555,878

SOLID ANTIPERSPIRANT AND/OR DEODORANT COMPOSITION IN THE FORM OF A WATER-IN-OIL EMULSION BASED ON SILICONE EMULSIFIERS AND ON WAXES; METHOD FOR TREATING BODY ODOURS

1. A solid composition in the form of a water-in-oil emulsion comprising, in a cosmetically acceptable carrier:i) at least one discontinuous aqueous phase;
ii) 10% to 40% by weight of a fatty phase comprising at least one wax in the form of crystallites having a shape factor of greater than or equal to 2 and having a melting point of 70 to 110° C.;
iii) 1% to 8% by weight of at least one alkyldimethicone copolyol of formula (I) below:

in which:
R1 denotes a linear or branched, C12-C20;
R2 denotes the group: —CnH2n—(—OC2H4—)x—(—OC3H6—)y—O—R3;
R3 denotes a hydrogen atom or a linear or branched alkyl radical containing from 1 to 12 carbon atoms;
a is an integer ranging from 1 to approximately 500;
b denotes an integer ranging from 1 to approximately 500;
n is an integer ranging from 2 to 12;
x denotes an integer ranging from 1 to approximately 50;
y denotes an integer ranging from 0 to approximately 49, with the proviso that, when y is other than zero, the ratio x/y is greater than 1;
and/or
a dimethicone copolyol of formula (II) below:

in which:
R4 denotes the group: —CmH2m—(—OC2H4—)s—(—OC3H6—)t—O—R5;
R5 denotes a hydrogen atom or a linear or branched alkyl radical containing from 1 to 12 carbon atoms;
c is an integer ranging from 1 to approximately 500;
d denotes an integer ranging from 1 to approximately 500;
m is an integer ranging from 2 to 12;
s denotes an integer ranging from 1 to approximately 50;
t denotes an integer ranging from 0 to approximately; with the proviso that the sum s+t is greater than or equal to 1;
iv) at least one antiperspirant active agent and/or one deodorant active agent;
v) 1% to 5% by weight of at least one nonionic surfactant having an HLB of greater than or equal to 10, wherein the at least one nonionic surfactant is an ethoxylated fatty alcohol or an ethoxylated fatty acid; and
vi) a polyethylene glycol of molecular weight greater than 400,000 g/mol as thickener.

US Pat. No. 10,555,876

PACIFIER WITH CLEANING BRUSH

1. An oral pacification device adapted to be at least partially inserted into the oral cavity, said device comprising:a. a bladder comprising an exterior shell and a fluid-filled chamber, the bladder forming a nipple at a posterior end and an at least first flange along an anterior end;
b. said chamber extending into said nipple and said at least first flange, a nipple interior in fluid communication with a flange interior, and
c. a bite block set within said bladder; said bite block comprising at least two prongs.

US Pat. No. 10,555,875

AUTOMATIC PACING SYSTEM FOR A BABY BOTTLE

1. A baby bottle for providing paced feeding, the bottle comprising:a storage chamber, containing a total amount of fluid;
a tube having a hollow volume and two opposing ends;
a nipple having a hole therein;
a pump for moving fluid from said storage chamber to said tube; and
a control system;
wherein a first of said two opposing ends contacts said nipple such that fluid in said hollow volume passes from said hollow volume through said hole;
wherein said hollow volume is in fluid communication with said storage chamber at a second of said two opposing ends;
wherein said pump subdivides said tube into a rearward segment including said second of said two opposing ends and a forward segment including said first of said two opposing ends;
wherein said control system automatically causes said pump to inhibit fluid movement for a first predetermined time window;
wherein said control system automatically causes said pump to initiate movement of a first predetermined amount of fluid from said rearward segment to said forward segment and through said hole after said first predetermined time window;
wherein said control system automatically causes said pump to inhibit fluid movement for a second predetermined time window after said movement of said first predetermined amount of fluid; and
wherein said control system automatically causes said pump to initiate movement of a second predetermined amount of fluid from said rearward segment to said forward segment and through said hole after said second predetermined time window.

US Pat. No. 10,555,874

HEALTHCARE MANAGEMENT SERVICES

Pillo, Inc., Boston, MA ...

1. A robotic interface system, comprising:a main body comprising:
an inlet port;
an outlet port;
a container assembly comprising:
a container member comprising a plurality of compartments and a plurality of gears; and
a ring member comprising a pill window and a gear engagement member operable to be selectively engaged with any one of the plurality of gears;
a first motor operative to couple or decouple the ring member to the container member;
a second motor coupled to the container member and operative to:
rotate both the container member and the ring member in concert with each other about a rotation axis relative to the main body to align the pill window with the inlet port, the outlet port, or any location between the inlet and outlet ports when the container member is coupled to the ring member; and
rotate the container member independently of the ring member about the rotation axis relative to the main body to align any one of the plurality of compartments with the pill window when the container member is decoupled from the ring member; and
a processor that is operative to control operation of the first and second motors in accordance with a pill insertion procedure or a pill dispersal procedure,
wherein, when the first motor is in a first position, the gear engagement member is engaged with one of the plurality of gears, and
wherein, when the gear engagement member is engaged with one of the plurality of gears, the container member and the ring member are configured to rotate in concert with each other in response to actuation of the second motor.

US Pat. No. 10,555,873

MODULAR MEDICATION DISPENSING SYSTEM

1. A modular medication dispensing system comprising:a medication dispenser support, said medication dispenser support comprising a base for placing the support on a surface, the base including a base dispensing opening, the medication dispenser support further comprising a magazine movably mounted on said base, said magazine comprising at least two removably receivable adaptors configured to removably receive a single portable dispenser, each of said at least two removably receivable adaptors comprising an adaptor opening, wherein when the adaptor dispensing opening of a first adaptor is in registry with the base dispensing opening, the first adaptor is in a dispensing position relative to the base;
at least one portable medication dispenser, the at least one portable medication dispenser being removably receivable on one of the at least two removably receivable adaptors of the medication dispenser support, the at least one portable medication dispenser being configured to accommodate a medication to be dispensed and being operable to dispense doses of the medication;
an actuator operatively coupled to the medication dispenser support, the actuator being configured to operate the at least one portable medication dispenser when it is removably received on one of the at least two removably receivable adaptors of the medication dispenser support; and
an electronic controller operatively connected to the actuator, the electronic controller controlling the operation of the actuator for operating the at least one portable medication dispenser removably received on one of the at least two removably receivable adaptors of the medication dispenser support to dispense the doses of the medication.

US Pat. No. 10,555,872

CONVENIENCE KITS FOR ASEPTIC STERILIZING AND DISPENSING

THORNE INTELLECTUAL PROPE...

1. Apparatus for being disposed within an uncontrolled, unsterilized and potentially contaminating surrounding environment while being used for sterilizing and dispensing liquid into containers and for capping and sealing the containers for delivery of protectively packaged sterile product into the environment, said apparatus comprising:a convenience kit comprising:
(a) a plurality of the containers, each container of said containers comprising an orifice through which liquid is dispensed into the container and a cap coupling;
(b) a plurality of caps, comprising one cap of the plurality of caps for each container, each cap comprising an exterior which is digitally accessible and has a connecting structure for capping, closing and sealing an associated container;
(c) a tray comprising cavities sized and shaped for holding each container and each cap in place during apparatus transport and, further, for immobilizing each container of said plurality of containers such that an associated cap of the plurality of caps can be facilely digitally affixed to the container;
(d) a filter component comprising a sterilizing grade filter disposed within a disk shaped housing and a pair of opposing extended length fluid communicating conduits, extending outward from said housing, providing a passageway to, through and from said filter;
(e) a plastic bag comprising an accessible opening for displacement of articles comprising said containers, said caps, and said tray into said bag before said opening is closed and sealed, and an exterior surface which completely envelopes and protects sterility of contents disposed therein thereby providing a completely shrouding shield for articles when said accessible opening is closed and sealed, said exterior surface further being continuous and comprising sufficient continuity and thickness to obstruct fluid displacement there through, having sufficient volume capacity to permit liquid to be displaced into each container and flexibility and suppleness for digital manipulation and having only a single hole, formed by perforating said exterior surface of said bag and closed by a gasket seal about a first conduit of said pair of opposing extended length fluid communicating conduits displaced through said hole, thereby providing for an aseptic pathway for displacing fluids into each container, said opening being closed and sealed once the contents are disposed therein and the bag and contents sterilized thereafter such that access to bag contents requires perforation of said exterior surface;
said filter component comprising a portion thereof disposed outside said bag, said portion comprising a second conduit of the pair of opposing extended length fluid communicating conduits which comprises a fitting which provides an entry orifice into the pathway, said fitting being open to the environment; and
a source for delivering non-sterile liquid through said filter, said source comprising a fitting, complimentary to said filter component second conduit fitting, which is affixed to said filter component conduit fitting for communicating liquid to the containers through first conduit of the pair of opposing extended length fluid communicating conduits and for digitally maneuvering said first conduit of the pair of opposing extended length fluid communicating conduits for dispensing liquid into each container without requiring displacement of said tray.

US Pat. No. 10,555,871

DEVICES AND METHODS FOR NEEDLELESS EXTRACTION AND ADMINISTRATION OF CONTENTS FROM VIALS

KLIM-LOC, LLC, Carbondal...

1. A cap assembly, comprising:an access member including a first section and a second section, the first section including a connection portion that is attachable to an extraction device that extracts contents of a reservoir, the connection portion including a first opening, the second section including a second opening in fluid communication with the contents of the reservoir when the access member is secured to the reservoir;
a valve member insertable into the access member so as to be in fluid communication with the first opening and the second opening and such that the valve member i) seals the contents of the reservoir at the first opening when the connection portion is not attached the extraction device, and ii) provides access to the contents of the reservoir through the first opening when the connection portion is attached to the extraction device;
a sealing member; and
a housing separate from the reservoir and configured to secure the access member and the sealing member to the reservoir such that the sealing member is between the reservoir and the access member,
wherein, when the valve member is inserted into the access member, the valve member extends from the connection portion of the access member to the second opening of the access member.

US Pat. No. 10,555,870

NON-INVASIVE DEVICE FOR SYNCHRONIZING CHEST COMPRESSION AND VENTILATION PARAMETERS TO RESIDUAL MYOCARDIAL ACTIVITY DURING CARDIOPULMONARY RESUSCITATION

ZOLL Medical Corporation,...

1. A system for improving cardiac output of a patient suffering from pulseless electrical activity, the system comprisingat least one sensor configured to monitor myocardial activity of the patient and generate signals indicative of the myocardial activity;
an automated chest compressor configured to apply chest compressions to the chest of the patient; and
a controller communicatively coupled with the at least one sensor and the automated chest compressor, the controller configured to:
receive the signals indicative of the myocardial activity from the at least one sensor,
analyze the received signals to determine if the patient is suffering from pulseless electrical activity,
determine a pattern of myocardial motion of the patient based on the received signals, and
trigger the automated chest compressor to synchronize the applied chest compressions from the automated chest compressor with the pattern of myocardial motion of the patient.

US Pat. No. 10,555,869

SYSTEM FOR ASSISTING A HELPER IN THE RESUSCITATION OF A PERSON WITH CIRCULATORY ARREST

Matthias Roth, Freiburg ...

1. A system for assisting a helper in performing chest compressions for resuscitation of a patient affected by a cardiac arrest, comprising a position sensor (4) and a mobile terminal device (6), which is connected to said position sensor (4) via an interface (6.1), said system being configured for detecting a circulation condition of said patient (1), characterized in thatthe system lacks a defibrillator,
the position sensor (4) is connected to a sticking plaster (5) as a support means, said sticking plaster (5) being a flexible strip of fabric material and/or plastic and having an adhesive layer, wherein the sticking plaster (5) with said position sensor (4) being fixable on the skin (3) over the sternum (2) of the patient (1) by use of said adhesive layer,
said position sensor (4) is an acceleration sensor,
the mobile terminal device (6) is a commercially available smartphone, which is configured such that standalone software applications are executable,
the system comprises a stand-alone software application (7), which is stored and executed on the smartphone;
the software application (7) and the mobile terminal device (6) are configured to automatically initiate an emergency call in the form of audio, video or text message to a rescue coordination center,
said software application (7) being configured for
a. establishing a communication link between the position sensor (4), the mobile terminal device (6) and the helper (8),
b. querying symptoms detectable by the helper (8),
c. evaluating said symptoms in terms of determination of the circulatory arrest,
d. instructing the helper (8) in conducting short term necessary measures for resuscitation of the patient (1) and
e. acquiring and analyzing data detected by the position sensor (4),
wherein said querying of symptoms and said instructing the helper (8) in carrying out short-term necessary measures are designed such that they can be understood by an untrained lay rescuer.

US Pat. No. 10,555,868

FOOT MASSAGING ASSEMBLY

1. A foot massaging assembly being configured to have a user's feet rolled thereon thereby facilitating said assembly to massage the user's feet, said assembly comprising:a stand being configured to be positioned on a support surface such that said stand is vertically oriented on the support surface, said stand including a first rod; and
a massage unit being slidably coupled to said stand wherein said massage unit is configured to massage a bottom side of each of a user's feet rolled on said massage unit thereby facilitating said massage unit to massage the user's feet, said massage unit being selectively positioned at a selected point along said stand, said massage unit comprising
a sleeve being slidably positioned around said first rod such that said sleeve is positioned at a selected point along said first rod, said sleeve having an outer surface, said sleeve including a pair of saddles, each of said saddles being directly coupled to said outer surface of said sleeve, said saddles being oppositionally positioned on said sleeve with respect to each other, each of said saddles having two upper ends forming an open upper end, and
a retainer being rotatably coupled to said sleeve wherein said retainer is configured to be manipulated, said retainer extending through said sleeve and selectively engaging said first rod such that said sleeve is retained at said selected point on said first rod; said stand comprises said first rod having a first end and a second end, said first rod having a first section being slidably coupled to a second section such that said first rod has a telescopically adjustable length; a second rod being coupled to said first end, said second rod being oriented perpendicular to said first rod; and a third rod being coupled to said second end, said third rod being oriented perpendicular to said first rod wherein said third rod is configured to abut the support surface thereby facilitating said second rod to be spaced from the support surface; and a plurality of rollers, each of a selected pair of said plurality of rollers being removably positioned in an associated one of said saddles wherein said selected pair of rollers is configured to have the user's feet rolled thereon.

US Pat. No. 10,555,867

MASSAGE MECHANISM

Xiamen Mas-Agee Electroni...

1. A massage mechanism, comprising:a housing,
a massage rock arm group,
massage heads, and
a drive apparatus;
wherein
the massage rock arm group comprises a left rock arm group and a right rock arm group, the left rock arm group and the right rock arm group are respectively mounted on a left side and a right side of the housing in a symmetric manner, and the left rock arm group and the right rock arm group both consist of an upper rock arm and a lower rock arm that are hingedly connected to one another;
the massage heads are disposed on the rock arms;
the drive apparatus is mounted in the housing; an upper spacing groove is disposed on each upper rock arm and a lower spacing groove is disposed on each lower rock arm;
spacing shafts corresponding to the spacing grooves are disposed on the housing; and
hinged joints, each between the upper rock arm and the lower rock arm of said left rock arm group and said right rock arm group and driven by the drive apparatus, are provided to drive the left rock arm group and the right rock arm group to perform spacing rocking defined by a path of the spacing grooves;
and wherein
the drive apparatus comprises a motor, a left worm wheel, a right worm wheel, a small left gear, a small right gear, a large left gear, a large right gear, a left handle, a right handle, a left connecting shaft, a right connecting shaft, and a pin rotating shaft, wherein an output shaft of the motor forms a worm, and the worm is simultaneously engaged with the left worm wheel and the right worm wheel; the small left gear and the small right gear are respectively mounted on a mounting shaft of the left worm wheel and a mounting shaft of the right worm wheel, and the small left gear and the small right gear are respectively engaged with the large left gear and the large right gear;
a left drive shaft extends from a center of the large left gear, the left drive shaft is connected to one end of the left handle, and the left connecting shaft connects another end of the left handle to the hinged joint of the left rock arm group; a step shaft, half of whose end portion is shaved off, extends from a center of the large right gear;
a shaft hole is processed and formed at a center of the step shaft; the pin rotating shaft is connected to the shaft hole in a sleeving manner with a clearance fit;
a pin perpendicular to an exterior cylindrical surface of the pin rotating shaft is disposed at a place, of an extension portion of the pin rotating shaft, that corresponds to a step position of the step shaft; the extension portion of the pin rotating shaft is connected to one end of the right handle, and the right connecting shaft connects the other end of the right handle to the hinged joint of the right rock arm group.

US Pat. No. 10,555,866

WHEELED WALKER WHEEL DIRECTION LOCK APPARATUS AND METHOD

ProtoStar, Inc., a Delawa...

1. A collapsible wheeled walker apparatus for facilitating a partially-supported walking gait on a walking surface for a user having one or two forearms and hands, the apparatus comprising:a frame having a first side frame and a second side frame defining a polygonal footprint on the walking surface;
a plurality of wheel assemblies coupled to the frame for supporting the frame above the walking surface and disposed at the vertices of the polygonal footprint, each wheel assembly including a wheel and a wheel fork having a lock depression, each wheel fork being rotatable relative to the frame about a respective axis of rotation;
a first upper body support and a second upper body support each independently coupled to and disposed at an adjustable height above the respective side frame, wherein the adjustable height of each upper body support is independently adjusted by a height adjusting mechanism, and wherein each upper body support is coupled to a respective handle for gripping by a respective user hand;
a plurality of wheel direction locks each coupled to the frame above a respective wheel assembly, each wheel direction lock having a wheel direction lock element moveable in a direction parallel to the axis of rotation of the respective wheel fork and adapted for insertion into the lock depression in the respective wheel fork to lock the respective wheel to a fixed moving direction; and
wherein when not in locked position the respective wheel assembly may freely turn around a respective shaft connecting the wheel fork to the frame above.

US Pat. No. 10,555,865

TORQUE CONTROL METHODS FOR AN EXOSKELETON DEVICE

Carnegie Mellon Universit...

1. A method of controlling an exoskeleton, comprising:receiving a measurement of a first torque applied to a rotational joint coupling a first component to a second component, the first torque being applied by a motor via a cable;
determining, based on the measurement of the first torque, a first portion of a second torque to apply to the rotational joint;
determining, based on the measurement of the first torque, a second portion of the second torque to apply to the rotational joint by:
determining, for an interval of a cycle, a target value as a function of an error value measured at the same interval of one or more previous cycles; and
determining, from the target value, a feed-forward response portion of the second torque;
determining a value of the second torque to apply to the rotational joint based on the first portion and the second portion including the feed-forward response portion; and
controlling the motor for applying the second torque to the rotational joint by the cable.

US Pat. No. 10,555,864

TRAINING APPARATUS, CALCULATING METHOD, AND PROGRAM

Murata Machinery, Ltd., ...

1. A training apparatus for training a user's four limbs including upper limbs and/or lower limbs according to a predetermined training program, the apparatus comprising:an operating rod for moving a held limb, the operating rod being supported to a stationary frame placed on or near a floor surface to be movable at two or more degrees of freedom;
a plurality of strength detectors for detecting strength components that are components of a strength applied to the operating rod in freedom degree directions where the operating rod is movable, and outputting strength component signals based on magnitudes of the detected strength components;
a plurality of motion position detectors for detecting motion positions of the operating rod in the freedom degree directions where the operating rod is movable;
a boundary direction speed calculator for calculating a boundary direction speed that is a speed component in a direction along a mobile region boundary line for defining a boundary of an operating rod mobile region for setting a range where the operating rod is movable;
a motion position predicting unit for calculating a predicted motion position where the operating rod is predicted to arrive when a resultant strength obtained by synthesizing the strength components in the freedom degree directions is applied to the operating rod on a current motion position of the operating rod; and
a motion speed calculator for calculating a speed including the boundary direction speed as a motion speed at which the operating rod moves when the predicted motion position is predicted to be outside the operating rod mobile region.

US Pat. No. 10,555,863

CRYOTHERAPY COMPRESSION SYSTEM

Jacob Randy Hall, Midway...

1. A therapy system, comprising:an inner layer having an inner surface and an outer surface;
an outer layer whose overall length is adjustable, the outer layer including first and second portions that are not part of, but are attached to, the inner layer, wherein an end of the first portion is completely separable from an end of the second portion so as to define a separation that takes the form of a gap in a material of the outer layer and wherein the gap is spanned by a spanning material, and wherein the outer layer includes a first free end and second free end that are releasably attachable to each other;
a therapeutic device removably positioned so that the inner surface of the inner layer is disposed between the therapeutic device and an extremity of a user when the extremity is positioned in an opening defined by the inner layer; and
an adjustable and manually operable tightening mechanism comprising a lace connected to the first and second portions of the outer layer and the lace is engaged with a mechanical lace tensioner that is operable to change, by either drawing the first and second portions toward each other or by allowing the first and second portions to move away from each other, a magnitude of a compressive force exerted by the outer layer on the extremity when the extremity is positioned within the opening defined by the inner layer, wherein the tightening mechanism is further operable to translate part of one of the first and second portions of the outer layer relative to the inner layer so as to vary a width of the gap.

US Pat. No. 10,555,862

TABLE ARMBOARD ADJUSTMENT ASSEMBLY

General Electric Company,...

1. A system for a patient support table, comprising:a board shaped to support an arm of a patient; and
a board actuation device configured to adjust a position of the board relative to the patient support table, the board adjustable by the board actuation device from a default position through a plurality of locked positions, wherein the board actuation device is configured to allow movement of the board away from the default position to any of the locked positions with a single actuation input without requiring increased actuation force even with increased loading on the board,
wherein the board actuation device comprises a first mechanical clutch including a first end coupled to a first support of the board, wherein the first end is drivable in a first direction and not a second direction while the single actuation input is not actuated, wherein the first end is drivable in the first direction and the second direction while the single actuation input is actuated, and wherein the first mechanical clutch is not electromechanically actuated.

US Pat. No. 10,555,861

DYNAMIC HEADSET APPARATUS

Neural Analytics, Inc., ...

1. A dynamic headset apparatus comprising:a head cradle having a top surface and a bottom surface opposite the top surface, wherein the top surface is configured to receive a head of a subject and the bottom surface has a convex shape and is configured to face a platform on which the dynamic headset apparatus is placed; and
a device comprising an instrument configured to transmit or receive acoustic energy with respect to the head of the subject and be adjacent to the head of the subject when the head of the subject is in the head cradle.

US Pat. No. 10,555,860

SURGICAL TABLES

Eschmann Holdings Limited...

1. A surgical table comprising:a base comprising a chassis and rotatably connected to the chassis a plurality of wheels for supporting the surgical table on a floor, wherein a total number of the plurality of wheels for supporting the surgical table on the floor is only four, a first of the four wheels being driven and comprised in a swivel castor rotatably connected to the chassis;
a column extending from the chassis;
a tabletop coupled to the column and providing a patient support surface, the tabletop having a longitudinal direction; and
a drive system for causing a rotation of the first wheel relative to the chassis thereby to drive the surgical table along the floor,
wherein the swivel castor comprises a frame rotatably connected to the chassis for free rotation about 360 degrees about a first axis relative to the chassis, wherein an orientation of the frame is lockable relative to the chassis with the first wheel being longitudinally oriented relative to the longitudinal direction of the tabletop, and the first wheel rotatably connected to the frame about a second axis orthogonal to the first axis and comprising an integral electric motor, and wherein the chassis has first and second opposed end portions, wherein the four wheels consist of the first wheel at the first end portion, a second wheel comprised in a second swivel castor at the first end portion, wherein the second swivel castor is not driven, and third and fourth wheels at the second end portion.

US Pat. No. 10,555,859

HEIGHT ADJUSTMENT DELIVERY TABLE

Industrial Woodworking Co...

1. A height-adjustable table comprising:a table top,
a base,
a column extending upwardly from said base to support said table top, said column configured to be adjustable in length to allow selective control over the height of the table top, said column including an assist cylinder having a locked state in which said length of said column is secured and an unlocked state in which said length of said column is readily adjustable; and
an actuator assembly operatively coupled to said assist cylinder to allow a user to manually place said assist cylinder in said unlocked state, said actuator assembly including a pair of paddle assemblies and a linear linkage, said paddle assemblies pivotally disposed toward opposite sides of said table top, said linear linkage having a first drive rod operatively engaged with one of said paddle assemblies, a second drive rod operatively engaged with another of said paddle assemblies and a pivot arm, wherein pivotal movement of any one of said paddle assemblies results in movement of said assist cylinder between locked and unlocked states, said pivot arm having a first portion, a second portion and a pivot portion, said first portion and said second portion disposed on opposite sides of said pivot portion, said first drive rod being operatively engaged with said first portion and said second drive rod being operatively engaged with said second portion; and
wherein said second portion is engaged with said assist cylinder, said pivot arm configured to reverse linear motion of said second drive rod.

US Pat. No. 10,555,858

INFANT CARE TRANSPORT DEVICE WITH SHOCK AND VIBRATION SYSTEM

1. An infant care transport device with a shock and vibration system, infant care transport device comprising:an enclosed infant care device comprising a patient support configured to underlie an infant;
at least one z-axis bed damper connecting the patient support to an infant care transport device main frame to dampen z-axis vertical movement of the patient support relative to the infant care transport device main frame; and
at least one radial x-y axis damper configured to dampen x-y axis movement between the infant care transport device main frame and an infant care transport device sub-frame;
wherein the at least one radial x-y axis damper comprises:
a radial damper housing attached to the infant care transport device main frame but not attached to the infant care transport device sub-frame,
a radial damper positioned within the radial damper housing, and
a stop attached to the infant care transport device-sub-frame and encircling the radial damper housing.

US Pat. No. 10,555,857

FLEXIBLE MEDICAL SUPPORTS

19. A patient support comprising a support for a patient's knees or legs, against which the patient can press as the patient rises from a seating position to a standing position, the support including a support structure and at least one support membrane connected to the support structure, the at least one support membrane configured to assist the patient in rising from the seating position to the standing position during which a front side of the patient's knee or leg is pressed against the at least one support membrane, the at least one support membrane having a thickness that increases gradually and uniformly from a bottom edge of the at least one support membrane to a top edge of the support membrane.

US Pat. No. 10,555,856

PATIENT LIFT SYSTEM

Amico Mobility Solutions ...

1. A patient lift system comprising:a trolley arranged to form a mechanical connection to a track, the trolley having a connection member; and
a lift unit chassis distinct from the trolley, the lift unit chassis defining a latching post operable to form a mechanical connection with the trolley responsive to the connection member connecting to the latching post, the lift unit chassis enclosing: a strap hub; and a motor.

US Pat. No. 10,555,855

MULTIFUNCTIONAL AIRCRAFT AISLE WHEELCHAIR AND RELATED SYSTEMS AND METHODS

Dane Technologies, Inc., ...

1. A wheelchair transfer system, comprising:(a) a wheelchair frame comprising a wheelchair seat and a wheelchair back;
(b) a lift system moveably coupled to the wheelchair back, the lift system comprising:
(i) first and second vertical rods;
(ii) a coupling component operably coupled to the wheelchair back, wherein the first and second vertical rods are slidably coupled to the coupling component, whereby the vertical rods can be moved laterally between an undeployed position and a deployed position;
(iii) first and second horizontal support arms operably coupled to the first and second vertical rods, respectively;
(iv) at least two pulleys operably coupled to the first and second support arms;
(v) a lift seat positionable on the wheelchair seat; and
(vi) a set of cables operably coupled to the at least two pulleys and the lift seat, wherein the lift seat can be moved between a raised position and a lowered position by the set of cables; and
(c) four wheels operably coupled to the transfer system.

US Pat. No. 10,555,854

SYSTEMS AND METHODS FOR DIRECTING FLUID FLOW IN A MATTRESS

Hill-Rom Services, Inc., ...

1. A person support system comprising:a mattress comprising a base support layer and at least one insert support layer, said base support layer configured to spatially locate said insert support layer; wherein said support layer includes a first arcuate boundary on a right side of said mattress and a second arcuate boundary on a left side of said mattress such that said first and second boundaries define
a horizontal flowpath to allow fluid to flow horizontally through said mattress, said first and second boundaries diverging from each other such that said fluid directed to a working region of the flow path, said boundaries subsequently converging toward each other to define at least one outlet directing fluid away from the working region to be exhausted from the mattress.

US Pat. No. 10,555,853

HEALTH CARE AIR-FLOW HEATING/COOLING MATTRESS

1. A health care air-flow heating/cooling mattress, comprising a mattress body and a heating/cooling pressurizing device connected with the mattress body; the mattress body comprises circular air sacs that bear pressure independently, square air sacs that bear pressure alternately, heating/cooling air supply pipes evenly distributed on the mattress body, and a pressurizing pipe connected to the square air sacs; the heating/cooling air supply pipes are connected with the heating/cooling pressurizing device; the pressurizing pipe runs inside the heating/cooling air supply pipes; the pressurizing pipe is connected with an air compressor; an air inlet of the pressurizing pipe is provided with a solenoid valve; the solenoid valve is controlled by chips; two sides of said heating/cooling air supply pipes are provided with small blow holes; the small blow holes of two adjacent heating/cooling air supply pipes are provided in staggered arrangement to prevent streams of air flow clash with one another; the circular air sacs are formed by a surface layer and a bottom layer; the surface layer and the bottom layer are pressed together to form a plurality of separate sealed air sacs which are the circular air sacs; a position on the mattress corresponding to a head of a user is arranged with the circular air sacs; the square air sacs are inflatable air sacs;the heating/cooling pressurizing device comprises a machine housing, a negative ion generator at an air exit of the machine housing; a fan provided inside the machine housing, and a TCH ceramic far infrared heating element provided inside the machine housing; an exit of the fan is in communication with an air inlet of the TCH ceramic far infrared heating element via a pipe; the fan is formed by a sound proof shell, a high speed smart motor disposed on an upper part of the sound proof shell, and blades provided at an output shaft of the high speed smart motor; the sound proof shell is formed by an upper part and a lower part; the lower part of the sound proof shell forms a spiral shape; the sound proof shell is provided inside a sealed container; shock reduction springs are provided between the sound proof shell and the sealed container; the sealed container is mounted inside the machine housing; a bottom part of the machine housing is provided with an air inlet opening; the air inlet opening is provided with a filter net covering.

US Pat. No. 10,555,852

CASTOR BASE WITH LOAD SENSOR

NOA Medical Industries, I...

1. An adjustable bed comprising:a main frame supporting a mattress;
a lift connected to said main frame and having an axle spaced from said connection to said main frame; and
a castor base rotationally connected to said axle, said castor base comprising:
two auxiliary beams, each auxiliary beam supporting at least one castor;
a load cell mounted to each of said auxiliary beams via a main housing and having a lever arm extending therefrom;
wherein said lever arm is of generally cylindrical shape; and
wherein a force applied to said lever arm in a direction generally perpendicular to a direction said lever arm extends from said main housing is detected by said load cell; and
a bushing positioned on each of said lever arms to rotate about said lever arm without rotating said lever arm it is positioned on;
wherein, said axle of said lift is connected to said bushing so that said axle can rotate relative to said castor base without rotating said lever arms; and
wherein, placing a mass on said main frame creates a force on each said lever arm detected by said load cell.

US Pat. No. 10,555,851

EMERGENCY PATIENT BED

1. An apparatus, comprising:a mobile base assembly;
a bed platform assembly coupled to said mobile base assembly and configured to support a mattress, said bed platform assembly includes a fold-down first equipment shelf located at a head location, a removably attachable large second equipment shelf which attaches to and protrudes horizontally from a side surface thereof, being capable of supporting one or more pieces of heavy equipment;
at least one storage drawer extendably coupled within said bed platform; and
an independent power supply coupled to said mobile base assembly;
a lockable patient locker coupled to said mobile base assembly;
at least one of a chart holder and a smart panel coupled to a foot end of said bed platform assembly, said smart panel includes a horizontal third equipment shelf along a top edge portion, enabling positioning of one or more pieces of associated equipment;
a privacy curtain removably coupled to said bed platform assembly;
a plurality of equipment mounts, one of said equipment mounts being coupled to each corner of said bed platform assembly, wherein said privacy curtain is coupled to and retained by said equipment mounts;
wherein said privacy curtain, comprises:
a plurality of pole elements, one of said pole elements being received within said one of said equipment mounts;
a cable interconnected between said pole elements; and,
a curtain coupled to and extending along said cable;
wherein independent power supply, comprises:
a rechargeable battery system;
a DC to AC converter; and
at least electrical outlet;
wherein said at least one support shelf comprises at least one of a head end support shelf coupled to a head end of said bed platform assembly and a foot end support shelf coupled to a foot end of said bed platform assembly; and
wherein said at least one support shelf comprises an equipment support shelf extendably coupled to a side of said bed platform assembly.

US Pat. No. 10,555,850

PATIENT SUPPORT SYSTEMS AND METHODS OF USE

Hill-Rom Services, Inc., ...

1. A patient support system adapted to provide a hospital bed having a head end, a foot end, a left side, and a right side, the system comprisinga patient support apparatus adapted to provide a bed frame, the patient support apparatus including a deck adapted to underlie a support surface, the deck being made up of a seat deck section, a foot deck section mounted to move relative to the seat deck section, and a head deck section mounted to pivot about an axis and to slide away from the seat deck section forming a gap between the seat deck section and the head deck section, and
a patient support surface adapted to provide a mattress, the patient support surface including a plurality of internal components, a ticking that provides a cover encasing the internal components, and a plurality of lugs configured to couple the patient support surface to the deck for movement therewith,
wherein the plurality of lugs include a first pair of lugs coupled to a head-end section of the ticking that extend from the ticking into apertures formed in the head deck section to couple the head-end section of the ticking to the head deck section for movement therewith during sliding of the head deck section away from the seat deck section, a second pair of lugs that extend from a foot-end section of the ticking into apertures formed in the foot deck section to couple the foot-end section of the ticking to the foot deck section for movement therewith relative to the seat deck section, and a third pair of lugs that extend from a section of the ticking between the head-end section and the foot-end section into apertures formed in the seat deck section to couple the ticking to the seat deck section.

US Pat. No. 10,555,849

OMNIDIRECTIONAL ELECTRIC HEALTHCARE BEDCHAIR

JIANGNAN UNIVERSITY, Wux...

1. An omni-directional electric medical care bed chair, comprising mecanum wheels (1), rollover prevention wheels (2), a bottom support (3), motors (4), a controller (5), a push rod device (6), a bed chair device (7), a cervical traction device (8), a shoulder joint rehabilitation device (9) and a pair of ankle joint rehabilitation devices (10); wherein one side of a rod-shaped part of each of the pair of ankle joint rehabilitation devices (10) is provided with a convex strip which is matched with one concave groove in leg surfaces (710) and is mounted on the concave groove by means of corresponding lock (712), and the pair of ankle joint rehabilitation devices are used for rehabilitation training on the ankle joints of the patient, and are adjustable in height.

US Pat. No. 10,555,848

PORTABLE CUSHION AND METHOD OF USE

1. An inflatable cushion comprising;an upper cushion portion;
said cushion further comprising side walls, a sectioned perforated top surface; and
a hollow interior;
a middle cushion portion;
said middle portion further comprising middle side walls, a middle perforated top surface and a hollowed interior divided in sections with interior middle dividers;
a bottom board;
said bottom board further comprising a solid base and three fluid flow tubes;
wherein each individual fluid flow tube is in mechanical communication with three air containment modules; wherein
said upper cushion forms a covering over said middle cushion; and
said middle cushion forms a covering over said bottom board wherein each of said air containment modules is housed individually into a section created by said interior middle dividers.

US Pat. No. 10,555,847

MULTI-FUNCTION CHAIR ATTACHMENT FOR DISABLED PERSONS

1. A multi-function attachment to assist a user to perform one or more tasks, the attachment comprising:an arm member having forward and back ends;
one or more coupling members provided to the arm member and configured to detachably secure the arm member to a chair; and
a support member configured to be detachably coupled to the second end of the arm member;
wherein at least a portion of the support member is configured to extend laterally from a point proximate the front end of the arm member to provide support for a device forward and above a seat portion of the chair;
a positioning insert formed substantially in an L-shape and configured to couple the arm member to the support member at a plurality of positions;
wherein the positioning insert includes a first portion configured to be inserted into the arm member, and a second portion configured to be inserted into the support member;
wherein the first portion of the positioning insert is provided with a plurality of pairs of through holes along a length of the first portion;
the arm member is provided with a pair of through holes configured to correspond with any of the pairs of through holes of the first portion of the positioning insert such that the positioning insert is arranged in one of a plurality of positions by receiving a pin through the through holes of the arm member and the first portion of the positioning insert;
wherein the first portion of the positioning insert is provided with three pairs of the through holes along the length of the first portion such that the positioning insert is selectively positionable at three different lengths of insertion into the arm member;
wherein the second portion of the positioning insert is provided with a pair of through holes; and
the support member is provided with a pair of through holes at a first end thereof to correspond with the pair of through holes in the second portion of the positioning insert such that the support member is secured to the second portion of the positioning insert by receiving a pin through the through holes of the support member and the second portion of the positioning insert.

US Pat. No. 10,555,846

DRIVE UNIT FOR A WHEELCHAIR AND A WHEELCHAIR PROVIDED WITH SUCH A DRIVE UNIT

DECON WHEEL AB, Hyltebru...

1. A drive unit (1) in combination with a wheelchair (2),said wheelchair (2) comprising control input means (8) and a structural frame (3) with two lateral frame elements (4, 5),
each of the two lateral frame elements (4, 5) supporting a respective one of two drive wheels (6, 7),
said drive unit (1) comprising two drive motors (13, 14) mounted within a drive shaft housing (10) and adapted to drive the respective one of the two drive wheels (6, 7) independently of each other based on control input from a driver via the control input means (8),
said drive shaft housing being releasably attached between the two lateral frame elements (4) of the wheelchair (2) and connected to the two drive wheels (6, 7) via quick-release couplings (11) arranged at each distal end (12) of the drive shaft housing (10), wherein:
the drive shaft housing (10) is divided into at least two sections (A, B), each of the two sections housing one of said two drive motors (13, 14);
the at least two sections (A, B) of the drive shaft housing (10) are telescopically moveable relative to each other for adjusting a width (w) of the drive shaft housing (10) to different wheelchairs having different distances between the lateral frame elements (4, 5) of the structural frame (3) of the wheelchair (2).

US Pat. No. 10,555,845

WHEELCHAIR REAR WHEEL SUPPORT ASSEMBLY AND DETACHABLE ARMREST

1. A detachable armrest assembly for a chair, said armrest assembly comprising a support housing, a detachable coupling for removably securing said support housing to a side member of a seat frame, an armrest secured to said support housing, vertical displacement means securing said armrest to said support housing to adjust the height of said armrest relative to said support housing, and connectable hinge means securable to said support housing for pivoting said housing in a rearward direction with said support housing disengaged from said detachable coupling, the detachable coupling having a latch actuator mechanism to permit said support housing to be pivoted in said rearward direction, said latch actuator mechanism having an external hand operable lever movable in a same direction as the rearward direction of the housing to initiate the pivoting of said housing in the rearward direction.

US Pat. No. 10,555,844

LIFT MECHANISM FOR WHEELCHAIRS IN VEHICLES

All-Terrain Conversions, ...

1. A combined wheelchair ramp and lift system for use with a sport utility vehicle (“SUV”) or a minivan, the system comprising:a ramp extension movable between a stowed position in which the ramp extension is positioned within a vehicle cabin of a sport utility vehicle (“SUV”) or a minivan and an extended position in which the ramp extension extends out of an opening in the vehicle cabin;
a ramp/lift assembly adjacent the ramp extension, wherein the ramp/lift assembly includes a ramp surface pivotal between a ramped position in which the ramp surface defines an inclined plane between a floor of the vehicle cabin and the ramp extension and a non-ramped position in which the ramp surface is substantially flush with the floor;
a first hinge configured to pivotally connect a first end of the ramp/lift assembly and the floor, wherein the first end of the ramp/lift assembly pivots about an axis extending substantially along a longitudinal axis of the vehicle cabin;
a second hinge configured to pivotally connect a second end of the ramp/lift assembly and the ramp extension, wherein the ramp extension pivots about an axis that is substantially parallel but offset from the axis about which the first end of the ramp/lift assembly pivots; and
a lift actuator configured to pivot the ramp/lift assembly between the ramped position and the non-ramped position, wherein the lift actuator has a lifting capacity configured to move the ramp surface to the non-ramped position under a weight of a wheelchair and wheelchair user.

US Pat. No. 10,555,843

ABSORBENT ARTICLE

DAIO PAPER CORPORATION, ...

1. An absorbent article in which an absorbent body is provided between a liquid permeable topsheet and a backsheet, comprising:an absorbent body compressed part provided from a front surface side of the absorbent body before stacking the liquid permeable topsheet to surround an area corresponding to a body fluid expelling portion; and
a front surface compressed part, formed separately from the absorbent body compressed part and not to overlap the absorbent body compressed part, provided from a front surface side of the liquid permeable topsheet,
wherein the absorbent body compressed part is provided so as to overlap a portion of the liquid permeable topsheet that has no compressed part.

US Pat. No. 10,555,842

UNDERPANTS-TYPE DISPOSABLE DIAPER

DAIO PAPER CORPORATION, ...

1. An underpants-type disposable diaper comprising an outer body constituting individually or integrally a front body and a back body, and an inner body including an absorber provided on an inner side of the outer body ranging from the front body to the back body, the outer body of the front body and the outer body of the back body being joined together at side edges to form side seal portions, thereby forming a waist opening and a pair of right and left leg openings, whereinthe outer body of the back body has a waist part defined as a front-back direction range having the side seal portions and an intermediate portion defined as the front-back direction range forming the leg openings,
the intermediate portion has cover parts positioned closer to lateral sides of the inner body,
the cover parts are formed at least by stacking an elastic sheet layer between a first sheet layer and a second sheet layer,
when the elastic sheet layer is extended in a width-direction, the first sheet layer and the second sheet layer are joined together directly or indirectly at a large number of dot-like joint portions arranged at intervals left in the width-direction and front-back direction, and
at least the intermediate portion of the cover parts in the front-back direction are configured such that an arrangement density of the dot-like joint portions becomes higher stepwise or continuously from width-direction outer edges to a width-direction central side.

US Pat. No. 10,555,841

FABRIC, PROTECTIVE GARMENTS MADE THEREFROM, AND METHODS OF MAKING

Moonrise Sisters, Inc., ...

1. An undergarment portion, comprising:an absorbent layer comprising a body-contacting surface, the absorbent layer having an absorbent capacity of at least about 300 g/m2, the absorbent layer configured to absorb between about 0.1 ml and about 50 ml of liquid, wherein the liquid is absorbed into fibers of the absorbent layer, the liquid being distributed across the absorbent layer via wicking; and
a hydrophobic layer disposed adjacent to the absorbent layer, the hydrophobic layer comprising an outer surface disposed on an opposite side of the absorbent layer from the body-contacting surface, the hydrophobic layer formed of a tightly knitted woven or nonwoven fabric having a weight of between about 5.2 oz/yd2 and about 7.2 oz/yd2, the fabric having fibers that have been coated or saturated with an elastic water repellent polymer, wherein the hydrophobic layer has a limited hydrostatic pressure resistance and is configured to limit transmission of liquid through the hydrophobic layer when a volume of liquid is between about 0.1 ml and about 50 ml, but allow liquid to pass through the hydrophobic layer when the volume of liquid is greater than 50 ml.

US Pat. No. 10,555,840

METHOD AND APPARATUS FOR MAKING DISPOSABLE ABSORBENT ARTICLE WITH ABSORBENT PARTICULATE POLYMER MATERIAL AND ARTICLE MADE THEREWITH

1. A method of making a disposable absorbent article comprising:providing a first support comprising a first grid comprising a first plurality of cross bars extending substantially parallel to and spaced from one another so as to form channels extending between the first plurality of cross bars, wherein the first plurality of cross bars each have a substantially straight outwardly facing edge extending across substantially the entire first grid;
providing a first printing roll having a first peripheral surface and a first plurality of reservoirs in the first peripheral surface arranged in an array comprising rows extending substantially parallel to and spaced from one another;
depositing absorbent particulate polymer material from the first plurality of reservoirs onto a first substrate disposed on the first grid, while the first support and first printing roll are arranged such that the first plurality of cross bars are substantially parallel to the rows of the first plurality of reservoirs, the absorbent particulate polymer material being deposited on the first substrate in a first pattern such that the absorbent particulate polymer material collects in rows on the first substrate formed between the first plurality of cross bars to create a first absorbent layer;
providing a second support comprising a second grid comprising a second plurality of cross bars extending substantially parallel to and spaced from one another so as to form channels extending between the second plurality of cross bars;
providing a second printing roll having a second peripheral surface and a second plurality of reservoirs in the second peripheral surface arranged in an array comprising rows extending substantially parallel to and spaced from one another;
depositing absorbent particulate polymer material from the second plurality of reservoirs onto a second substrate disposed on the second grid, while the second support and second printing roll are arranged such that the second plurality of cross bars are substantially parallel to the rows of the second plurality of reservoirs, the absorbent particulate polymer material being deposited on the second substrate in a second pattern such that the absorbent particulate polymer material collects in rows on the second substrate formed between the second plurality of cross bars of the second support to create a second absorbent layer; and
combining the first and second absorbent layers together in juxtaposed relation in a nip between the first and second supports.

US Pat. No. 10,555,839

WOUND DRESSING

1. A wound treatment apparatus, comprising:a dressing comprising:
a cover layer, the cover layer comprising at least one opening;
a wound contact layer;
a first layer disposed in a space between the cover layer and the wound contact layer, wherein the first layer comprises a foam material;
an absorbent layer positioned in fluid communication between the first layer and the wound contact layer, wherein the absorbent layer is below the first layer, wherein the absorbent layer comprises a lower surface configured to be facing a wound site when the dressing is applied over the wound site and an opposite upper surface and a plurality of through holes extending from the lower surface to the upper surface of the absorbent layer, wherein the absorbent layer is configured to distribute fluid throughout the absorbent layer via a wicking action so that fluid is drawn from the wound site and stored throughout the absorbent layer;
a connector in fluid communication with the space for connecting the space to a source of negative pressure; and
a hydrophilic member in fluid communication with the absorbent layer that permits moisture vapor and gas through, the hydrophilic member positioned in fluid communication between the first layer and the connector, wherein the hydrophilic member covers the at least one opening in the cover layer; and
a second layer disposed in the space, wherein the second layer is below the absorbent layer and above the wound contact layer, the first layer and the second layer have a larger perimeter than the absorbent layer.

US Pat. No. 10,555,838

METHODS AND DEVICES FOR APPLYING CLOSED INCISION NEGATIVE PRESSURE WOUND THERAPY

KCI Licensing, Inc., San...

1. A treatment system, the system comprising:a tension relief layer comprising a central elastic region coupled between a pair of opposing wings, wherein at least a portion of each opposing wing of the pair of opposing wings has an adhesive lower surface, wherein the pair of opposing wings are configured to be stretched away from one another towards a first tensile configuration, and wherein while held in the first tensile configuration, the pair of opposing wings are configured to adhere to skin on opposing sides of an incision;
an indicator layer comprising opposing pull tabs respectively coupled to at least a portion of an upper surface of the pair of opposing wings, the opposing pull tabs each having elongated extension portions configured to mate in an interlocked arrangement;
a porous region within the central elastic region configured to allow for a passage of material from the incision or wound to an upper surface of the tension relief layer; and
a conformable sealing layer configured to be applied over the tension relief layer and configured to adhere to tissue adjacent the incision or wound forming a sealed space around at least a portion of the incision or wound.

US Pat. No. 10,555,837

INTRAOCULAR PROSTHESIS

RAINBOW MEDICAL LTD., He...

1. Intraocular apparatus (i) shaped and sized to be implanted entirely in a subject's eye, (ii) having an anterior side and a posterior side, and (iii) configured for use with an extraocular imaging device, the intraocular apparatus comprising:a photovoltaic energy receiver on the anterior side of the intraocular apparatus configured to receive energy from outside the eye and to power the intraocular apparatus;
a photodiode on the anterior side of the intraocular apparatus configured to receive data from the extraocular imaging device; and
an application-specific-integrated-circuit (ASIC) on the posterior side of the intraocular apparatus comprising (i) circuitry configured to process the data from the photodiode into an image, (ii) an electronic display configured to emit light representing the image, and (iii) exactly three through-silicon vias connecting the ASIC to the photovoltaic energy receiver and to the photodiode.

US Pat. No. 10,555,836

WELDING HELMET HAVING A HUD-TYPE AUTO-DARKENING FILTER

Tecmen Electronics Co., L...

1. A welding helmet comprising:a helmet housing;
a headband structure for securing the helmet housing;
an auto-darkening filter secured in the helmet housing; and
a light-permeable protective sheet installed in the helmet housing in front of the auto-darkening filter,
wherein the auto-darkening filter comprises:
a body;
a filter lens module installed in the body of the auto-darkening filter, the filter lens module configured to provide automatic light filtering; and
a head-up display installed aside the filter lens module in the body of the auto-darkening filter, arranged obliquely relative to the filter lens module and the protective sheet, and facing toward the protective sheet, the head-up display configured to luminously reveal operating parameters of the filter lens module such that, when the filter lens module is in a transparent state, the luminously revealed operating parameters of the filter lens module are (i) projected obliquely relative to the filter lens module by the head-up display such that one part of a light ray emitted by the head-up display transmits through the light-permeable protective sheet and (ii) reflected obliquely relative to the protective sheet, via the protective sheet, through the filter lens module for visibility by an operator of the welding helmet such that another part of the emitted light ray is reflected by the light-permeable protective sheet and through the filter lens module to provide a virtual image of the luminously revealed operating parameters a given distance from the light-permeable protective sheet.

US Pat. No. 10,555,835

LASER EYE SURGERY SYSTEMS AND METHODS OF TREATING VITREOUS AND OCULAR FLOATERS

OPTIMEDICA CORPORATION, ...

1. A laser surgical system for making incisions in ocular tissues, the system comprising:a laser system comprising a scanning assembly, a laser operable to generate a laser beam configured to incise ocular tissue, and an imaging device configured to generate images of ocular tissues; and
a control system operably coupled to the laser system and configured to:
operate the imaging device to locate a posterior of a lens in an eye;
operate the imaging device to locate a retina in the eye;
operate the imaging device to locate a vitreous body in a vitreous humor in the eye;
process the image data to determine, based on the location of the vitreous body, a treatment scanning pattern for scanning a focal zone of the laser beam for performing one or more incisions in the vitreous humor, wherein the one or more incisions are surfaces that collectively form closed boundaries completely surrounding a volume that completely contains the vitreous body to isolate the vitreous body, without any focal zone locations or incisions cutting through the volume; and
operate the laser system, wherein positioning of the focal zone is guided by the control system based on the treatment scanning pattern to perform the one or more incisions in the vitreous humor.

US Pat. No. 10,555,834

VITRECTOMY PROBE WITH ROTARY CUTTER AND ASSOCIATED DEVICES, SYSTEMS, AND METHODS

Novartis AG, Basel (CH)

1. An ophthalmic surgical system, the system comprising: a vitrectomy probe comprising: a housing sized and shaped for grasping by a user; a cutter sized to penetrate an eye, the cutter extending from the housing, wherein the cutter comprises: an outer cutting tube coupled to the housing, the outer cutting tube having an outer port formed therein, wherein the outer port is sized and shaped to receive tissue; and an inner cutting member disposed within the outer cutting tube, the inner cutting member rotatable about a longitudinal axis thereof, the inner cutting member comprising a first cutting surface that rotates across the outer port to cut the tissue when the inner cutting member is rotated; a drive shaft disposed within the housing; an actuator coupled to the drive shaft and disposed within the housing, the drive shaft linearly reciprocable in response to actuation by the actuator; and a drive member coupled to the drive shaft and the inner cutting member, the inner cutting member rotatable about the longitudinal axis thereof in response to the linear reciprocable motion of the drive shaft, wherein the drive member comprises a swash plate.

US Pat. No. 10,555,833

APPARATUS AND METHODS FOR OCULAR INJECTION

Clearside Biomedical, Inc...

1. An apparatus, comprising:a medicament container configured to contain a medicament;
a hub configured to be coupled to the medicament container, the hub defining a passageway configured to receive a puncture member therethrough; and
an actuation rod at least partially disposed within the medicament container,
the medicament container, the actuation rod, and the puncture member collectively configured such that (1) a distal end portion of the actuation rod moves within the medicament container in response to a force on the actuation rod when a distal end portion of the puncture member is disposed within a first region of a target tissue, and (2) movement of the distal end portion of the actuation rod within the medicament container in response to the force on the actuation rod is limited when the distal end portion of the puncture member is disposed within a second region of the target tissue, the force having a magnitude less than a threshold value.

US Pat. No. 10,555,832

INTRAOCULAR LENS INJECTOR ASSEMBLY INCLUDING A SHUTTLE AND METHOD OF USING SAME

1. A method of assembling an intraocular lens (IOL) injector, comprising:providing an injector body having a plunger and a shuttle reception opening that is formed into and along a length of the injector body, and is defined at least in part by a first sidewall and an opposed second sidewall;
providing a shuttle that is a separate piece from the injector body and is insertable into the shuttle reception opening, the shuttle comprising:
a first wing including a first portion of a shuttle lumen wall;
a second wing including a second portion of a shuttle lumen wall, the first wing and the second wing being coupled together by an at least one hinge; and
a frame comprising a handle for facilitating insertion of the shuttle into the shuttle reception opening, the handle extending between ends of the shuttle and connecting handle attachment portions formed at the ends of the frame, the handle being disposed above and between the first and second wings to permit the wings to move between an open state and a closed state; and
inserting the shuttle into the shuttle reception opening, the shuttle, the first sidewall, and the opposed second sidewall being sized and shaped such that the first wing and the second wing interfere with the first sidewall and the opposed second sidewall, respectively, and
wherein, upon insertion and when in the closed state, the first portion of the shuttle lumen wall and the second portion of the shuttle lumen wall define at least a portion of an operative shuttle lumen that is sized for receiving and holding the IOL.

US Pat. No. 10,555,831

HYDROGEL SUBSTANCES AND METHODS OF CRYOTHERAPY

Zeltiq Aesthetics, Inc., ...

1. A method for treating a subject's skin, comprising:applying a hydrogel to the skin, the hydrogel including an ice nucleating agent capable of forming ice crystals in the presence of water, the ice nucleating agent being encapsulated within a polymer structure of the hydrogel such that the ice nucleating agent does not come in direct contact with a surface of the skin;
cooling the hydrogel and the skin with a cooling applicator to arrive at a cooling treatment temperature for the skin; and
freezing the skin via the hydrogel.

US Pat. No. 10,555,830

FIXTURE FOR ARM DURING MEDICAL TREATMENT

1. A fixture configured to be attached to an arm of a patient, comprising:an arm holder configured to be arranged adjacent an elbow of the patient and comprising an arm support and a belt configured to attach the arm to the arm support;
a wrist holder attached to the arm holder configured to support the wrist; and
a link for attaching the arm holder to a fixture board configured to be arranged on a bed board for a patient, wherein a distance between the arm holder and the fixture board is adjustable, said link including,
a first swivel joint arranged at said fixture board,
a second swivel joint arranged at said arm holder, and
a link arm connecting said first and second swivel joints.

US Pat. No. 10,555,829

ORTHOSIS JOINT

1. An orthosis joint, comprising:a base body comprising:
a receptacle for a proximal component;
a bearing point for a distal component pivotably coupled to the base body;
at least one receiving element releasably secured to and extending proximally beyond a proximal outer surface of the base body, the at least one receiving element having a bore;
a functional element arranged at least partially within the bore and configured to interact with the distal component, the functional element including a spring element, the functional element and the at least one receiving element being provided as an integrated, modular assembly.

US Pat. No. 10,555,828

BRACE HAVING AN INFLATION CONTROL

DJO, LLC, Vista, CA (US)...

1. An orthopedic walking brace comprising:a shell component;
a plurality of inflatable cells positioned within said shell component; wherein each of said plurality of inflatable cells is positioned at a different location within said shell component and configured to provide individualized compression to said different location;
a control comprising:
a diverter that rotates within a manifold body,
an inlet port and a plurality of outlet ports, the control being positionable in two or more orientations, and each outlet port being in fluid communication with a respective one of the plurality of inflatable cells;
an on-board inflation component in fluid communication with the inlet port of the control;
wherein positioning of the control to a first orientation creates a first fluid path between the inflation component and a first inflatable cell of the plurality of inflatable cells, and positioning of the control to a second orientation creates a second fluid path between the inflation component and a second inflatable cell of the plurality of inflatable cells.

US Pat. No. 10,555,827

MULTIFUNCTIONAL ORTHOSIS DEVICE AND METHOD OF USE

FastForm Research Ltd., ...

24. An orthosis device comprising:a substantially rigid thermo-formable substrate having a substrate profile defined by a substrate top edge, an opposite substrate bottom edge, and opposite substrate side edges interconnecting the substrate top and bottom edges, the substrate profile being substantially symmetrical about a centerline thereof, the centerline being centered vertically along the substrate from the substrate top edge to the substrate bottom edge, the substrate having a main body portion and opposite lower wing portions, each of the lower wing portions being joined to the main body portion along a substantially angled hinge relative to the centerline, the substrate further having a central portion formed having a substrate thumb hole and a selectively removable thumb hole cover installed within the substrate thumb hole; and
a liner pad coupled to the substrate in a substantially abutting arrangement, the liner pad having a pad profile defined by a pad top edge, an opposite pad bottom edge, and opposite pad side edges interconnecting the pad top and bottom edges, the pad profile substantially corresponding to the substrate profile, the liner pad further having a pad thumb hole substantially corresponding to the substrate thumb hole;
wherein the device becomes moldable when activated by a forming temperature above ambient, and the symmetry of the substrate enables the device to be used in both left hand and right hand applications; and
wherein the thumb hole cover is configured to be selectively retained within the substrate thumb hole to provide a substantially continuous support surface for a hand of a patient during use of the device in an ulnar gutter application and to be selectively removed from the substrate thumb hole to allow a thumb of a patient to be inserted through the substrate thumb hole during use of the device in a radial gutter application, such that the device may be used in both radial and ulnar gutter applications.

US Pat. No. 10,555,826

HEMOSTASIS VALVE AND DELIVERY SYSTEMS

Bolton Medical, Inc., Su...

1. An x-valve, comprising:a) a valve housing;
b) at least one sealing component within the valve housing, the sealing component defining a plurality of slots that intersect with each other; and
c) a support layer that includes nitinol and partitions the sealing component, the support layer including a peripheral ring and a plurality of arms extending from the peripheral ring to points proximate to intersection of the plurality of slots, the plurality of arms embedded within the sealing component, whereby the x-valve can form a seal about a guidewire extending through the x-valve.

US Pat. No. 10,555,825

ROTATION OF A MEDICAL DEVICE DURING CRIMPING

ABBOTT CARDIOVASCULAR SYS...

1. A method, comprising:using a stent or scaffold, the stent or scaffold having an outer diameter and the outer diameter having a before crimping size;
using a balloon of a balloon catheter;
using a crimping device having a plurality of blades configured to form an aperture, wherein the blades are displaced relative to each other to increase or decrease the size of the aperture during crimping, and wherein the aperture has an axis surrounded by the blades; and
crimping the stent or scaffold to the balloon, the crimping comprising:
placing the stent or scaffold on the balloon,
aligning the stent or scaffold and balloon catheter with the aperture axis, including supporting the balloon catheter using a bearing having a bearing axis parallel to the aperture axis,
wherein when the blades of crimping device rotate about the aperture axis the aperture size changes, whereupon the catheter rotates about the bearing axis in response to the rotation of the blades about the aperture axis, and
reducing the stent or scaffold outer diameter from the before crimping size to a first size.

US Pat. No. 10,555,824

STENT DEVICE DELIVERY SYSTEM WITH INWARDLY TAPERING STENT BED

C. R. Bard, Inc., Murray...

1. A method of making a stent device delivery system, comprising:loading a device into a retractable outer sheath comprising a sleeve, the retractable outer sheath having a delivery position that retains the device and a deployed position that radially frees the device;
positioning an inner catheter radially and axially within a lumen of the device, wherein the inner catheter comprises an inwardly tapered bed; and
cold-drawing the sleeve:
to reduce a diameter of the sleeve;
to squeeze the device from an expanded configuration into a reduced delivery configuration; and
to engage a radially inner surface of the device with a radially outer surface of the inwardly tapered bed.

US Pat. No. 10,555,823

DEVICE FOR ENDOVASCULAR AORTIC REPAIR AND METHOD OF USING THE SAME

AORTIC INNOVATIONS, LLC, ...

1. An intraluminal vascular prosthesis assembly, having a hollow cylindrical body with a first end and a second end, comprising:at its first end, a first vascular prosthesis portion; and
at its second end, a second vascular prosthesis portion;
wherein the vascular prosthesis assembly has a stent portion provided between the first vascular prosthesis portion and the second vascular prosthesis portion;
wherein the stent portion is received within the aortic arch;
wherein the stent portion defines a top portion that spans, but does not extend into, the brachiocephalic artery, left common carotid artery, and left subclavian artery when placed within the aortic arch of a patient; and
wherein a surface of the stent portion facing the brachiocephalic artery, left common carotid artery, and left subclavian artery is free of graft material to allow fluid flow therethrough.

US Pat. No. 10,555,822

DYNAMIC KNEE BALANCER WITH FORCE OR PRESSURE SENSING

Synvasive Technology, Inc...

1. A method for conducting a surgical procedure on a knee joint, the method comprising:temporarily attaching a trial femoral component to a distal end of a femur, the trial femoral component including at least one positioning feature to provide position information for an implant;
adjusting the trial femoral component to modify a position of the at least one positioning feature relative to the distal end of the femur;
sensing the position of the at least one positioning feature;
communicating position information corresponding to the sensed position to a robotic surgery system; and
shaping the distal end of the femur with the robotic surgery system in response to the position information, wherein the shaping the distal end of the femur comprises at least one of cutting, milling, or burring the distal end of the femur with the robotic surgery system.

US Pat. No. 10,555,821

METHOD AND APPARATUS FOR SPINAL INTERBODY FUSION INCLUDING FIXATION OR LOCKING PLATE

1. A spinal fusion implant for insertion into an intervertebral disc space between adjacent, spaced apart vertebral bodies in a spinal joint, the spinal fusion implant comprising:a generally parallelepiped main body having a predetermined length, width, and thickness, said main body having a proximal end and a distal end;
a rectangular distal retention plate having a distal end and a proximal end, the distal retention plate disposed at said distal end of said main body, said distal retention plate having (i) a first, non-rotated position that is co-planar with said main body, and (ii) a second, rotated position that is not co-planar with said main body, with a first portion of said distal retention plate extending above said main body such that said distal retention plate contacts a first vertebral body disposed above said main body, and a second portion of said distal retention plate extending below said main body such that said distal retention plate contacts a second vertebral body disposed below said main body;
a central rod having a distal end and a proximal end, said central rod being rotatably and slidably mounted to said main body, with said distal end of said central rod protruding from said distal end of said main body and said distal retention plate being fixedly mounted to said distal end of said central rod such that said distal retention plate rotates when said central rod is rotated, and with said proximal end of said central rod terminating distal to said proximal end of said main body; and
a port formed in said proximal end of said main body, said port being aligned with said central rod such that said proximal end of said central rod is accessible from said proximal end of said main body to rotate and slide said central rod from said proximal end of said main body;
wherein said central rod is configured to (i) slide distally relative to said main body so as to displace said distal retention plate distally away from said distal end of said main body so as to adjust a distance between the distal end of the main body and the proximal end of said distal retention plate, (ii) rotate said distal retention plate from its first, non-rotated position to its second, rotated position, and (iii) displace said distal retention plate proximally toward said distal end of said main body so as to adjust a distance between said distal end of said main body and said proximal end of said distal retention plate, whereby to bring said first portion of said distal retention plate into contact with the first vertebral body disposed above said main body, and bring said second portion of said distal retention plate into contact with the second vertebral body disposed below said main body.

US Pat. No. 10,555,820

SPINAL IMPLANT STRUCTURE AND KIT THEREOF

GROUP INNOMED BIOTECH CO....

1. A spinal implant structure having a folded position and an expansion position, comprising:a body, the body being a hollow-cored cylinder when the spinal implant structure is in the folded position, the body comprising:
a first part;
a second part, the second part not overlapping the first part; and
at least one expansion arm, the expansion arm having an end connecting with the first part and another end being a free end; and
at least one support arm, the support arm having an end connecting with the expansion arm and another end connecting with the second part,
wherein the support arm comprises a plurality of weakened sections so that, in response to a change in a distance between the first part and the second part, the support arm bends at the weakened sections and thus drives the expansion arm to move, thereby increasing an included angle between the expansion arm and the first part, expanding the spinal implant structure, and causing the spinal implant structure to turn into the expansion position, and
wherein the first part, the second part, the expansion arm, and the support arm are formed integrally.

US Pat. No. 10,555,819

INTERVERTEBRAL SPINAL IMPLANT

Globus Medical, Inc., Au...

1. A cervical intervertebral implant for implantation in an intervertebral space between vertebrae, the implant comprising:a body having a front end, a rear end and opposed side walls extending between the ends, the body having an outer perimeter with a trapezoidal shape and an inner perimeter about an internal chamber, the body comprising:
an upper surface and a lower surface, the upper surface defined by a solid upper outer rim and a spaced apart solid upper inner rim and the lower surface defined by a solid lower outer rim and a spaced apart solid lower inner rim;
a solid front wall extending at the front end between at least the solid upper outer rim and the solid lower outer rim;
a solid rear wall extending at the rear end between at least the solid upper outer rim and the solid lower outer rim;
each of the side walls including at least one solid cross strut extending between the solid upper rims and at least one solid cross strut extending between the solid lower rims, wherein each solid cross strut has an associated curved contoured portion;
each of the side walls including at least one solid support structure extending between the upper surface and the lower surface, the solid support structure occupying a minimal space within each side wall; and
a porous structure integrally formed with the solid upper rims, the solid lower rims, each of the solid cross struts, and each of the solid structures in each of the side walls, the porous structure extending from the body outer perimeter to the body inner perimeter, and
wherein each solid cross strut and associated curved contoured portion define a contour of a surface serration.

US Pat. No. 10,555,818

SPINAL FUSION IMPLANT FOR OBLIQUE INSERTION

Institute For Musculoskel...

1. A unitary intervertebral fusion implant for spinal fusion between two adjacent vertebrae comprisinga superior convex surface,
an inferior convex surface, and
four vertical edges, wherein each edge has a different height than the other edges, wherein each edge comprises a superior end and an inferior end, wherein each superior end terminates at the superior convex surface, and wherein each inferior end terminates at the inferior convex surface,
wherein the superior convex surface comprises a first outermost point, the first outermost point being the apex of the implant, and
wherein the inferior convex surface comprises a second outermost point, wherein the apex is the highest point of the implant, and wherein none of the four vertical edges contains the apex, and
wherein the implant is configured for a transforaminal or posterior approach at an oblique insertion angle.

US Pat. No. 10,555,817

IN-SITU FORMED INTERVERTEBRAL FUSION DEVICE AND METHOD

DePuy Synthes Products, I...

1. An intervertebral fusion device, comprising:a first sidewall having cranial and caudal margins that define a first height dimension therebetween, wherein the first sidewall comprises titanium;
a second sidewall opposite the first sidewall and having cranial and caudal margins that define a second height dimension therebetween, wherein the second sidewall comprises titanium;
a load-bearing polymeric body disposed between the first and second sidewalls; and
a cavity disposed within the polymeric body;
wherein the device is positionable within an intervertebral disc space such that the first and second height dimensions are oriented along a height dimension between cranial and caudal vertebrae that define the disc space,
wherein footprints of the first and second sidewalls represent substantially equal arcs of two different concentric circumferences, and
wherein the first sidewall and the second sidewall are configured to abut an upper vertebra and a lower vertebra that define the intervertebral disc space.

US Pat. No. 10,555,816

SYSTEMS AND METHODS OF A GLENOID COMPONENT

Shoulder Innovations, LLC...

1. A glenoid component for use in a shoulder prosthesis, comprising:a body including a first surface that is convex and a second surface opposite the first surface, the second surface is concave and free of openings;
a third surface connecting the first surface to the second surface;
a channel extending from a first channel opening of the first surface through the body to a second channel opening defined on the third surface, the channel having a channel axis extending through the first channel opening and the second channel opening, the channel axis intersecting a first plane defined by the first channel opening at an angle transverse to the first plane, the channel configured to receive a bone engagement member to attach the body to a shoulder bone;
at least one alignment member extending from the first surface to align the body to the shoulder bone; and
a bone engagement member to attach the body to the shoulder bone, the bone engagement member to occupy at least a portion of the channel.

US Pat. No. 10,555,815

SURGICAL KIT FOR CARTILAGE REPAIR COMPRISING IMPLANT AND A SET OF TOOLS

Episurf IP-Management AB,...

1. A design method for design of an individually customized implant for bone or cartilage resurfacing, based on a 3D virtual model of the implant, the design method comprising:identifying a damage area of a joint by taking computed tomography (CT), cone beam computed tomography (CBCT), or magnetic resonance imaging (MRI) images of the joint;
presenting a virtual 3D view of said identified damage area;
placing in said virtual 3D view at least two overlapping substantially circular shapes so that the combined area of the overlapping substantially circular shapes covers or partly covers said identified damage area, said placing comprising:
placing at least two points each from where an axis will originate from on the bone surface of the joint in or nearby the damage area or on a simulated bone surface which is a virtually created surface covering the damage area;
selecting axes-distance;
selecting diameters of substantially circular shapes between 10-30 mm;
selecting coverage of the implant area over the damage area, wherein the coverage is between 50-100%; and
selecting angles of the axes and each of which originates from a point of said simulated bone surface and has an angle of 0-40 degrees in relation to a bone-axis which extends in a normal direction in relation to a tangential plane of the simulated bone surface in that point;
selecting thickness of the implant by using the surfaces of the substantially circular shapes placed on a simulated bone surface and extruding the area of the substantially circular shapes to create a cylindrical body, outwards towards the virtual cartilage surface resulting in a simulated implant cartilage surface which is based on a simulated healthy cartilage surface in/of that particular area, and wherein the implant further optionally comprises at least one protruding peg;
creating a simulated repair surface which is individually customized in mimicking a non-damaged cartilage surface of the joint for which said damage area was identified; and
creating a 3D virtual implant from the placement of the at least two overlapping substantially circular shapes and the simulated repair surface.

US Pat. No. 10,555,814

ULTRASOUND PROBE FOR CARDIAC TREATMENT

Edwards Lifesciences Corp...

1. A method for treatment of a heart, the method comprising:loading a flexible needle into a guide attached to an ultrasound probe, the ultrasound probe comprising an elongate shaft extending from a proximal handle to a distal end of the ultrasound probe;
inserting the ultrasound probe into a patient by way of an opening in skin of the patient;
navigating the distal end of the ultrasound probe to a location adjacent to an exterior surface of the heart or pericardium;
identifying a first puncture site on the exterior surface based on observing structures on the exterior surface and within the heart using an ultrasound transducer disposed within the distal end of the ultrasound probe;
advancing the flexible needle to the first puncture site using the guide;
using the flexible needle to puncture the exterior surface at the first puncture site;
identifying a second puncture site on a septal wall of the heart using the ultrasound transducer;
passing the flexible needle through the septal wall into a left ventricle of the heart at the second puncture site;
identifying a third puncture site on a posterior wall of the left ventricle of the heart using the ultrasound transducer;
using the flexible needle to puncture the posterior wall at the third puncture site; and
withdrawing the flexible needle away from the third puncture site.

US Pat. No. 10,555,813

IMPLANTABLE DEVICE AND DELIVERY SYSTEM FOR RESHAPING A HEART VALVE ANNULUS

BOSTON SCIENTIFIC SCIMED,...

1. An implant for reducing heart valve regurgitation comprising:a frame having upper crowns, lower crowns and struts between the upper and lower crowns, the frame having a tissue engaging configuration having a tissue engaging diameter and an annulus remodeling configuration where the frame has an annulus remodeling diameter that is less than the tissue engaging diameter;
a plurality of anchoring members coupled with the lower crowns of the frame for engaging cardiac tissue proximate the heart valve annulus; and
a plurality of collars coupled with the upper crowns of the frame, wherein when force is applied to the collars, the collars slide along the upper crowns and the struts to move the frame from the tissue engaging configuration towards the annulus remodeling configuration and wherein each collar includes at least one flex section configured to reduce friction between the collar and the upper crowns and the struts.

US Pat. No. 10,555,812

METHODS FOR ANCHORING A HEART VALVE PROSTHESIS IN A TRANSCATHETER VALVE IMPLANTATION PROCEDURE

MEDTRONIC VASCULAR, INC.,...

1. A method of securing a heart valve prosthesis to a heart of a patient comprising:implanting a heart valve prosthesis having an anchor guide within one of a native heart valve or a previously implanted heart valve prosthesis, the anchor guide being fixed at each of a first end and a second end to the heart valve prosthesis, the anchor guide having an elongate guide member releasably secured thereto with an end or ends of the elongate guide member extending externally of the patient;
advancing an anchor tool having an anchor clip loaded therein along the elongate guide member to the anchor guide of the heart valve: prosthesis;
positioning the anchor tool at a securement site on the heart valve prosthesis; and
releasing the anchor clip from the anchor tool at the securement site to secure the heart valve prosthesis to the heart.

US Pat. No. 10,555,811

DELIVERY DEVICE FOR A STENTED PROSTHETIC HEART VALVE

MEDTRONIC, INC., Minneap...

1. A delivery device for percutaneously delivering a stented prosthetic heart valve, the stented prosthetic heart valve being radially expandable from a radially compressed delivery configuration to a radially expanded deployed configuration, the delivery device comprising:a capsule assembly, wherein the capsule assembly includes a capsule and a proximal shaft coupled to a proximal end of the capsule, the capsule including an expanded configuration wherein the capsule has a first outer diameter and a collapsed configuration wherein the capsule has a second outer diameter smaller than the first outer diameter;
a handle including a housing and an actuator mechanism, wherein the actuator mechanism is coupled to a proximal portion of the proximal shaft and is configured to selectively move the proximal shaft and the capsule relative to the housing to release the stented prosthetic heart valve; and
an outer stability shaft defining a lumen, the outer stability shaft coupled to the handle and configured to receive the proximal shaft within the lumen of the outer stability shaft, the outer stability shaft having an inner diameter, wherein the first outer diameter of the capsule is greater than the inner diameter of the outer stability shaft and the second outer diameter of the capsule is smaller than the inner diameter of the outer stability shaft, and wherein the capsule in the expanded configuration has an inner diameter along an entire length of the capsule that is not greater than an outer diameter of the outer stability shaft.