US Pat. No. 11,111,458

CYCLOPROPYLMETHOXY DERIVATIVES


1. A compound, wherein the compound has formula II:



and wherein R? is a C6 linear or branched alkyl or alkenyl group.

US Pat. No. 11,111,456

LUBRICANT COMPOSITION FOR HYDRAULIC OIL

DL Chemical CO., LTD., S...


1. A lubricant composition, comprising:61.28 to 96.64% by weight of a base oil, 0.5 to 30% by weight of a liquid olefin copolymer, 0.1 to 3% by weight of a phosphorothioate compound, and 0.05 to 2% by weight of phosphonium phosphate,
wherein the phosphorothioate compound is at least one selected from the group consisting of monophosphorothioate, diphosphorothioate, triphosphorothioate, methylphosphorothioate, ethylphosphorothioate, and sulfonylphosphorothioate, and
wherein the phosphonium phosphate has a structure of Chemical Formula 7 below





US Pat. No. 11,111,453

METHOD FOR LUBRICATING INTERNAL COMBUSTION ENGINE

ENEOS Corporation, Tokyo...


1. A cylinder lubricating oil composition for a premix combustion crosshead diesel engine, the lubricating oil composition comprising:a mineral base oil or a synthetic base oil or a mixture thereof, as a lubricant base oil; and
(A) a metallic detergent, the component (A) comprising:(A1) a calcium borate-overbased metallic detergent in an amount of 0.35 to 1.70 mass % in terms of calcium on the basis of the total mass of the composition, the component (A1) comprising a calcium borate-overbased calcium salicylate detergent, or a calcium borate-overbased calcium sulfonate detergent, or any combination thereof; and
(A2) a calcium carbonate-overbased metallic detergent in an amount of 0.35 to 1.30 mass % in terms of calcium on the basis of the total mass of the composition, the component (A2) comprising a calcium carbonate-overbased calcium salicylate detergent, or a calcium carbonate-overbased calcium sulfonate detergent, or any combination thereof,

wherein an integrated intensity ratio of peaks of CaO in a X-ray diffraction spectrum of an ash is no more than 16.5%, the ash being obtained by incinerating the lubricating oil composition in an air at 950° C.;
a molar ratio B/Ca of a boron content B (unit: mol) of the lubricating oil composition derived from the component (A) and a calcium content Ca (unit: mol) of the lubricating oil composition derived from the component (A) is no less than 0.52; and
the lubricating oil composition is used to lubricate at least a cylinder in a premix combustion crosshead diesel engine, wherein the premix combustion crosshead diesel engine uses a main fuel having a flash point of no more than 15° C.

US Pat. No. 11,111,452

COMPOUND COMPRISING POLYAMINE, ACIDIC AND BORON FUNCTIONALITIES AND ITS USE AS A LUBRICANT ADDITIVE

TOTAL MARKETING SERVICES,...


1. A product resulting from the reaction of at least:a hydroxybenzoic acid, optionally substituted by a hydrocarbyl group,
a boron compound,
an amine component selected from a di-fatty-alkyl(ene) polyalkylamine composition comprising one or more polyalkylamines of formulae (I) or (II):




wherein,
each R is, independent of the other R, an alkyl moiety or an alkylene moiety with 4 to 30 carbon atoms, which is linear or branched,
n and z are independent of each other either 0, 1, 2, or 3, and
when z is greater-than 0 then o and p are independent of each other either 0, 1, 2, or 3,
or derivatives thereof selected from products wherein one or more of the NH moieties of the dialkyl polyalkylamines are methylated, alkoxylated, or both,
whereby said polyalkylamine composition comprises at least 3% by weight of branched compounds of formula (I) or (II), with regards to the total weight of polyalkylamine compounds (I) and (II) in the composition, branched compound signifying that:
in formula (I) at least one of n and z are greater than or equal to 1,
in formula (II) n is greater than or equal to 1.

US Pat. No. 11,111,451

MERCAPTOAZOLE DERIVATIVES AS LUBRICATING ADDITIVES

The Lubrizol Corporation,...


1. A method of reducing copper corrosion in an internal combustion engine comprising contacting the internal combustion engine with a lubricating composition comprising:a. an oil of a lubricating viscosity;
b. 0.01 wt % to 5 wt % of a mercaptoazole-acrylic adduct having the formula (IV) or (V):





wherein R6 is hydrogen or a C1-C20 hydrocarbyl group; R7 is a linear or branched hydrocarbyl group having at least two carbon atoms; and R8 is a C1-C20 hydrocarbyl group and is linear, branched, homocyclic, heterocyclic, or a combination thereof and wherein the hydrocarbyl groups have no non-hydrocarbon substituents;c. an antiwear agent containing phosphorus and present in an amount such that said lubricating composition has at least 300 ppm phosphorus based on a total weight of said lubricating composition; and
d. an antioxidant.

US Pat. No. 11,111,449

USE OF NITROGEN COMPOUNDS QUATERNISED WITH ALKYLENE OXIDE AND HYDROCARBYL-SUBSTITUTED POLYCARBOXYLIC ACID AS ADDITIVES IN FUELS AND LUBRICANTS

BASF SE, Ludwigshafen (D...


1. A method for preparing a gasoline fuel composition or diesel fuel composition, comprising:adding to a gasoline or diesel fuel, a salt or a purified form thereof of a hydrocarbyl-substituted polycarboxylic acid and a hydrocarbyl epoxide quaternized nitrogen compound obtained by reaction of an alkylamine of formula (3) with a quaternizing agent of formula (4) to obtain a quaternized nitrogen compound of formula (2a), formula (2b) or a mixture thereof according to Eq. (I); wherein the reaction with the quaternizing agent is in the presence of a free hydrocarbyl-substituted polycarboxylic acid of formula (1);




wherein
radicals R2, R3 and R4 are each independently a straight-chain or branched, C1-C7-alkyl residue,
R5 is H or an aliphatic or aromatic radical comprising 1 to 10 carbon atoms,
R1 is a long-chain hydrocarbyl having a number-average molecular weight (Mn) of 85 to 20,000; and
R is H or a radical CH2CH(R5)OH or a radical CH(R5) CH2OH.

US Pat. No. 11,111,447

ROTATING AND MOVABLE BED GASIFIER PRODUCING HIGH CARBON CHAR


1. A gasifier for gasifying fuels comprising:a container having an inside and an outside;
a generally vertical open fire tube extending into the inside of the container and including one or more fingers extending from a lower portion of the fire tube;
a rotating fuel bed located within the inside of the container and spaced from the one or more fingers of the fire tube wherein the distance between the bed and the fingers of the fire tube is greater than zero;
an adjustable mechanism for elevating and lowering the fire tube, the mechanism elevating or lowering the fire tube relative to the bed to adjust the distance between the one or more fingers of the fire tube and the bed;
a motor and a drive shaft connecting the motor to the bed for rotating the bed;
a cap permanently affixed to a top of the drive shaft;
a recess, said recess being a protrusion extending from a top of the container;
a fuel opening and an air opening on top of the recess;
an adjustable cover for closing the air opening; and
fasteners passing through the recess to engage corresponding locations of the cap.

US Pat. No. 11,111,446

TEMPERATURE-CONTROLLING MEASURE FOR THE HYDROGENATION SLURRY BED REACTOR AND ITS DESIGN METHOD AND USE

CATECH TECHNOLOGY CO., LT...


1. A temperature-controlling method employed in a hydrogenation slurry bed reactor system, comprising:setting three control points in turn from low to high:
automatically injecting cold hydrogen in response to determining that the reactor system reaches control point 1;
automatically injecting cold oil in response to determining that the reactor system reaches control point 2; wherein each pressure relief point is opened automatically in response to determining that the reactor system reaches control point 3;
wherein the control point 1 is: 425° C.T<440° C. and/or P19 MPa; the control point 2 is: 440° C.T<455° C. and/or P19 MPa; the control point 3 is: T455° C. and/or P20 MPa;
setting the pressure relief point before and/or after a circulation pump of the reactor in response to determining that internal circulation is set in the reactor system; and
setting the pressure relief point at the bottom of the reactor system in response to determining that the internal circulation is not set in the reactor system, at least one pressure relief valve being set at each pressure relief point;
wherein the at least one pressure relief valve is controlled by a temperature or pressure in the reactor system, a number of temperature measurement points being at least 1, a number of pressure measurement points being at least 1 and further comprising: setting a temperature self-control valve and/or hand control valve, the pressure relief valve opening and an alarm being triggered in response to determining that the reactor system operates at more than 455° C. or an operating pressure is more than 20 MPa; and opening all control valves and shutting down the reactor system in response to determining that the reactor system temperature is more than 465° C. and the operating pressure is more than 21.5 MPa.

US Pat. No. 11,111,445

SEPARATION SYSTEM FOR HIGH PRESSURE PROCESSING SYSTEM


1. Method of separating and purifying products from a high pressure processing system adapted for processing a feed stream comprising carbonaceous material at a pressure of at least 150 bar and a temperature of at least 300° C., where converted feed stream is cooled to a temperature in the range 50 to 250° C., and depressurized to a pressure in the range 1 to 150 bar, the method comprising:separating the depressurized, converted feed stream into a gas phase, an oil phase, and a water phase comprising water soluble organics, dissolved salts and optionally suspended particles in a first phase separator; and
purifying the oil phase from the first phase separator by mixing it with one or more washing agents, and separating the oil phase from the one or more washing agents in at least one further separation step,
wherein gas is separated from the converted feed stream in a flash separator prior to entering the first phase separator, and the pressure of the flash separator is in the range 1 to 150 bar, and
wherein an acidifying agent is added to at least one of the one or more washing agents comprising water, and the acidifying agent comprises CO2 containing process gas.

US Pat. No. 11,111,442

FISCHER-TROPSCH SYNTHESIS PROCESS COMPRISING A CATALYST PREPARED BY ADDITION OF AN ORGANIC COMPOUND IN GAS PHASE

IFP Energies Nouvelles, ...


1. A Fischer-Tropsch process for preparing a catalyst and synthesizing hydrocarbons using the catalyst, which comprises:preparing the catalyst by the following steps:
a) providing a porous support containing silica, alumina, and at least one partial or non-partial single spinel phase MAl2O4 or mixed spinel phase MxM?(1-x)Al2O4 in which M and M? are distinct metals selected from the group consisting of magnesium (Mg), copper (Cu), cobalt (Co); nickel (Ni), tin (Sn), zinc (Zn), lithium (Li), calcium (Ca), caesium (Cs), sodium (Na), potassium (K), iron (Fe), and manganese (Mn) and in which x is between 0 and 1, the values of 0 and 1 themselves being excluded;
b) adding at least one organic compound containing oxygen and/or nitrogen and comprising one or more chemical functions selected from the group consisting of carboxylic, alcohol, ester, amine, amide, ether, dilactone, carboxyanhydride, aldehyde, ketone, nitrile, imide, oxime and urea functions, but not comprising sulfur, to the porous support;
c) bringing said porous support into contact with at least one solution containing at least one salt of a precursor of the phase comprising at least one Group VIII metal selected from the group consisting of iron (Fe) and cobalt (Co);
d) drying the porous support obtained at the end of step c);wherein step b) is carried out before or after steps c) and d) and is carried out by bringing together said porous support with a porous solid comprising said at least one organic compound containing oxygen and/or nitrogen under conditions of temperature, pressure and duration such that a fraction of said organic compound is transferred in the gaseous state from said porous solid to the porous support; and
using the catalyst obtained from the above steps to prepare hydrocarbons by bringing the catalyst into contact with a feedstock comprising synthesis gas under a total pressure of between 0.1 and 15 MPa, under a temperature of between 150 and 350° C., at an hourly space velocity of between 100 and 20,000 volumes of synthesis gas per volume of catalyst per hour and with an H2/CO molar ratio of the synthesis gas of between 0.5 and 4.


US Pat. No. 11,111,441

METHOD FOR PRODUCING FERROCOKE

JFE STEEL CORPORATION, T...


1. A method for producing ferrocoke comprising molding and carbonizing a mixture of coal and iron ore,wherein the coal is (i) a single coal having a load average value of ash content of not less than 10.7% and a load average value of mean maximum reflectance of not less than 0.81%, or (ii) a mixture of plural coals and a non-caking or slight caking coal, the mixture having a load average value of ash content of not less than 10.7% and a load average value of mean maximum reflectance of not less than 0.81%.

US Pat. No. 11,111,440

APPARATUS, SYSTEM, AND METHOD FOR SHALE PYROLYSIS

PYRO DYNAMICS, LLC, Lind...


1. A shale pyrolysis system comprising:a retort comprising a first side and a second side, the second side opposite the first side, the first side and the second side comprising descending angled surfaces at alternating angles to produce zig-zag motion of shale descending through the retort;
steam distributors coupled to the first side and collectors coupled to the second side to produce crossflow of steam and heat across the descending shale from the first side to the second side; and
a steam temperature control subsystem coupled to the steam distributors and configured to deliver higher-temperature steam to an upper portion of the retort and lower-temperature steam to a lower portion of the retort.

US Pat. No. 11,111,439

MICROWAVE APPARATUS FOR PYROLYZING CARBONACEOUS MATERIAL AND RELATED METHOD

MICROWAVE RENEWABLE TECHN...


1. An apparatus comprising:a microwave generator that generates microwave energy at 915 MHz and having a rating of 100 kW;
a microwave reduction applicator having a microwave reduction chamber;
the microwave reduction chamber having a volume;
an inert gas generator assembly configured to saturate the microwave-reduction-chamber volume with an inert gas by introducing the inert gas into the chamber under a pressure that is above local atmospheric pressure;
the microwave reduction applicator having a ceiling;
the microwave reduction applicator having an infeed port and an outfeed port;
the microwave reduction applicator configured to receive and process organic-containing material having a depth between about 1 inch and about 3 inches;
a conveyor belt assembly configured to continuously transport organic-containing material into the chamber via the infeed port, through the chamber, and out of the chamber via the outfeed port;
the conveyor belt assembly having a conveyor belt;
a height defined as the shortest distance between the conveyor belt and the ceiling, wherein the height ranges from approximately 7 inches to approximately 11 inches;
a waveguide assembly operatively communicating with the microwave generator and the microwave reduction applicator, the waveguide assembly configured to distribute microwave energy from the microwave generator to the microwave reduction applicator, the waveguide assembly further configured to emit polarized microwaves into the microwave reduction chamber; and
a dual quartz window assembly having a first quartz window and a second quartz window forming a sealed space therebetween, the dual quartz window assembly recessed an operable distance from the microwave applicator and upstream of the waveguide inlet, wherein the second quartz window is positioned downstream at least approximately 12 inches from the first quartz window, and

wherein the second quartz window is recessed approximately at least 12 inches within the waveguide assembly from the microwave reduction applicator.

US Pat. No. 11,111,438

DISPLAY PANEL AND DISPLAY DEVICE

TCL CHINA STAR OPTOELECTR...


1. A display panel, comprising:a first substrate;
a second substrate disposed opposite to the first substrate, the second substrate comprising a black matrix;
a liquid crystal cell, the liquid crystal cell comprising the first substrate, the second substrate, and a liquid crystal composition; and
a supportive blocking wall disposed between the first substrate and the second substrate, the supportive blocking wall disposed in a region of the black matrix, the supportive blocking wall dividing the liquid crystal cell into a first liquid crystal region and a second liquid crystal region, wherein the first liquid crystal region is filled with the liquid crystal composition containing a first vertical alignment agent, and the second liquid crystal region is filled with the liquid crystal composition containing a second vertical alignment agent,
wherein a structural formula of the first vertical alignment agent is:




wherein the A is selected from the group consisting of a primary amino group, a secondary amino group, a tertiary amino group, —OH, —COOH, —SOOCH3, —CN, —Si(CH3)3, —Si(OCH3)3, and —SiCl3; the Sp is —O—, the n is 1; the P is a polymerizable group; and the R is alkyl.

US Pat. No. 11,111,435

TUNGSTEN CHEMICAL MECHANICAL PLANARIZATION (CMP) WITH LOW DISHING AND LOW EROSION TOPOGRAPHY

VERSUM MATERIALS US, LLC,...


1. A chemical mechanical planarization (CMP) composition comprising:at least one amidine compound, or hydrolyzed derivative thereof, selected from the group consisting of 2-phenyl-2-imidazoline and 1,8-Diazabicyclo[5.4.0]undec-7-ene;
silica;
hydrogen peroxide;
ferric nitrate;
glycine;
malonic acid; and
a solvent.

US Pat. No. 11,111,432

TRIANGULAR CARBON QUANTUM DOTS AND COMPOSITIONS AND USES THEREOF

BEIJING NORMAL UNIVERSITY...


1. A triangular carbon quantum dot, which comprises a conjugated triangular structure comprising at least four aromatic rings,wherein said conjugated triangular structure comprises a side functional group and the content of carbon atoms in said triangular carbon quantum dot is 50 weight % or more.

US Pat. No. 11,111,431

METHOD FOR REDUCING THE PERMEABILITY OF A SUBTERRANEAN FORMATION TO AQUEOUS-BASED FLUIDS

Dow Global Technologies L...


1. A method of modifying the permeability to water of a subterranean formation, the method comprising:injecting into the subterranean formation an aqueous composition including:
from about 1 to about 10 weight percent of one or more clay stabilization salts; and
from about 0.005 percent to about 2 percent, by weight, of a sulfonated epoxy composition comprising the reaction products of:(i) an epoxide-containing compound having an average of more than one epoxide group per molecule, the epoxide-containing compound being represented by the Formula I:






where Q is selected from a divalent aromatic group —Ar—; Ar-L-Ar, wherein L is selected from a direct bond, C1 to C8 alkylene, —SO2—, —S—, >C?O, or —O—; a divalent cycloaliphatic group K having from 4 carbons to 8 carbons, or —R1—K—R2— where R1 and R2 are independently a C1 to C3 alkylene group;
(ii) a primary amino sulfonate, the primary amino sulfonate being represented by the Formula II:






wherein Z is an aliphatic, cycloaliphatic, polycycloaliphatic, or aromatic hydrocarbon group optionally substituted with one or more alkyl groups and M is Li+, Na+, K+, or NH4+, and the molar ratio of (i) the epoxide-containing compound to (ii) the primary amino sulfonate being 5:1 to 1:5;
(iii) a primary monoamine alkylene oxide oligomer, the primary monoamine alkylene oxide oligomer being represented by the Formula III:






wherein R3 is —H, C1 to C12 alkyl or cycloalkyl, R4 is a covalent bond, C1 to C12 alkyl or cycloalkyl, R5 and R6 are independently —H, C1 to C12 alkyl or cycloalkyl, and x and y independently have a value from 0 to 75 with the proviso that at least one of x or y is equal to or greater than 1; and
(iv) optionally a primary monoamine, a secondary diamine, a monohydroxyalkyl primary monoamine, a dihydroxyalkyl primary monoamine, a trihydroxyalkyl primary monoamine, a mono hydroxycycloalkyl primary monoamine, a dihydroxycycloalkyl primary monoamine, or a trihydroxycycloalkyl primary monoamine.


US Pat. No. 11,111,430

METHANE HYDRATES IMPROVED HYDROSTATIC PRESSURE OF FOAM FRACTURING

Halliburton Energy Servic...


1. A method of fracturing a subterranean formation, comprising:(a) preparing a treatment fluid comprising an aqueous base fluid, and a viscosifying agent, wherein the treatment fluid has a first density;
(b) introducing the treatment fluid into a wellbore extending into a subterranean formation wherein the wellbore has perforations allowing fluid flow communication between the subterranean formation and the wellbore;
(c) pressurizing a liquefied natural gas and then vaporizing the thus pressurized liquefied natural gas;
(d) introducing the thus vaporized natural gas into the treatment fluid so that the treatment fluid is foamed by the introduction of the vaporized natural gas and so that the vaporized natural gas forms gas hydrates with the aqueous base fluid in the treatment fluid in situ within the wellbore;
(e) introducing the treatment fluid containing the gas hydrates into a portion of the wellbore extending into the subterranean formation where the temperature and pressure at the portion are sufficient to convert the gas hydrates into a gaseous state so as to further foam the treatment fluid by the conversion of the gas hydrates into a gaseous state; and
(f) introducing the thus foamed treatment fluid into the subterranean formation at a pressure sufficient to fracture the formation.

US Pat. No. 11,111,429

COMPOSITIONS AND METHODS FOR DELAYED CROSSLINKING IN HYDRAULIC FRACTURING FLUIDS

ChampionX USA Inc., Suga...


1. A method of making an injectable solution, the method comprising:reacting a dialdehyde having 2 to 4 carbons and a non-polymeric cis-hydroxyl compound in an aqueous solution to form a competing agent solution comprising a competing agent and excluding a borate; and
combining a crosslinkable polymer and the competing agent solution in produced water to form the injectable solution, the produced water containing about 10 ppm to 500 ppm boron as dissolved reactive boron species.

US Pat. No. 11,111,427

SELECTIVE SALT MANAGEMENT FOR WELLBORE FLUIDS USING MICROGEL PARTICLES

Halliburton Energy Servic...


1. A method of controlling contaminant metal ions in a treatment fluid having dominant metal ions during treating of a well, comprising:pumping downhole into the well the treatment fluid, the treatment fluid comprising salt water or brine in which there is the dominant metal ions and the contaminant metal ions, wherein metal ions of the dominant metal ions are different from metal ions of the contaminant metal ions, and
introducing into the treatment fluid a polymer microgel comprising a plurality of polymer particles, each polymer particle having a polymeric backbone bearing at least one moiety where such moiety is a chelating agent capable of selectively bonding with the contaminant ions over the dominant metal ions, wherein the polymer microgel is introduced so as to reduce contaminant metal ions by selectively chelating with the contaminant metal ions instead of the dominant metal ions to thus leave the dominant metal ions in the well treatment fluid.

US Pat. No. 11,111,426

IN-SITU SALINITY ADJUSTMENT TO IMPROVE WATERFLOODING PERFORMANCE IN OIL-WET CARBONATE RESERVOIRS

SAUDI ARABIAN OIL COMPANY...


1. A composition for increased hydrocarbon production from a hydrocarbon-bearing reservoir, the composition comprising:a saltwater solution suitable for injection into the hydrocarbon-bearing reservoir for water flooding, the saltwater solution having a salinity; and
a plurality of nanocapsules, where the nanocapsules are operable to be suspended amongst the saltwater solution, where the nanocapsules have an overall positively charged outer surface at respective outer shells of the nanocapsules, where the nanocapsules encapsulate water molecules without salt or minerals within the nanocapsules, and where the nanocapsules are operable to release the water molecules in the hydrocarbon-bearing reservoir proximate overall negatively charged zones to reduce salinity and alter wettability via release of water molecules in situ proximate an area of release.

US Pat. No. 11,111,425

METHODS AND SYSTEM TO REDUCE IMPERCEPTIBLE LAB EXPERIMENTS

Schlumberger Technology C...


1. A method comprising:defining operational parameters for an initial composition design based on user-specified design considerations including: well environment in which a composition will be used, including wellbore modeling parameters related to vertical stresses, horizontal stresses and permeability; operating temperature ranges; cost constraints; and transport to a wellsite;
using a three-dimensional model on a computing system having a computer processor to estimate properties of a reservoir based on obtained reservoir data;
generating an initial composition design based on the defined operational parameters and the three-dimensional model;
predicting the performance of the initial composition design using a statistical model;
comparing the performance of the initial composition design with the operational parameters;
optimizing the initial composition design according to the defined operational parameters by adding at least one of a corrosion inhibitor, a scale inhibitor, a buffering agent, a rheology modifier, a chelant, a temperature stabilizer, or a solvent so as to minimize wear on well equipment located in the well environment;
further optimizing the initial composition design by iteratively repeating the stages of predicting, comparing, and optimizing; and
outputting a final composition design suitable for use in a well.

US Pat. No. 11,111,424

HEAT TRANSFER COMPOSITIONS, METHODS, AND SYSTEMS

HONEYWELL INTERNATIONAL I...


1. A refrigerant comprising at least about 97% by weight of the following four compounds, with each compound being present in the following relative percentages:about 41 to about 49% by weight trifluoroiodomethane (CF3I);
about 36 to about 44% by weight 1,1,1,2-tetrafluoropropene (HFO-1234yf);
about 12 to about 15% by weight difluoromethane (HFC-32); and
1 to 3.5±0.2% by weight carbon dioxide (CO2).

US Pat. No. 11,111,418

SYSTEMS FOR SECURING PROTECTIVE FILMS TO SURFACES OF SUBSTRATES

ZAGG Inc, Midvale, UT (U...


1. A system for applying a protective film to an electronic device, comprising:a protective film with a configuration that corresponds to a configuration of a surface of an electronic device on which the protective film is to be secured, the protective film including a lower surface that carries adhesive material and an upper surface opposite from the lower surface;
a release layer over the upper surface of the protective film, the release layer including an upper surface facing away from the protective film;
a cap shield over the upper surface of the release layer; and
a liner secured to the adhesive material on the lower surface of the protective film, the liner including a liner strip and a main liner, the liner including a breakable boundary between the liner strip and the main liner, the breakable boundary enabling the liner strip to be fractured from the main liner and to be removed from the adhesive material without removing the main liner from the adhesive material.

US Pat. No. 11,111,417

ADHESIVES FOR ASSEMBLING COMPONENTS OF INERT MATERIAL

SICPA HOLDING SA, Prilly...


1. An adhesive formulation for bonding two materials at least one of which being an impregnated or impermeabilized material, comprising40 to 80 wt.-% of an epoxy monomer; and
15 to 30 wt.-% of an oxetane monomer; and
0.1 to 10 wt.-% of an adhesion promotor; and
0.1 to 5 wt.-% of a sensitizer; and
1 to 10 wt.-% of a radiation and temperature activatable photoinitiator or a mixture of a photoinitiator and a thermal initiator,

and further comprising a fluorurated epoxy monomer being 3-Perfluorooctyl-1,2-propenoxide.

US Pat. No. 11,111,412

POLISHING COMPOSITION, METHOD FOR PRODUCING POLISHING COMPOSITION, AND POLISHING METHOD

FUJIMI INCORPORATED, Kiy...


1. A polishing composition comprising silica of which a maximum peak height in a weight change rate distribution curve obtained by thermogravimetric measurement in a range of 25° C. or higher and 250° C. or lower is ?0.011 or more and less than 0, a pH at 25° C. of the polishing composition being less than 6.0, wherein:a true density of the silica is more than 1.70 g/cm3 and 2.18 g/cm3 or less;
the silica has an average primary particle size of 100 nm or less; and
the silica has a degree of association of 1.9 to 5.0.

US Pat. No. 11,111,406

COPOLYMER AND ANTIFOULING COATING COMPOSITION CONTAINING THE SAME

NIPPON PAINT MARINE COATI...


1. A vehicle resin for an antifouling coating composition,the vehicle resin being a copolymer comprising:
a structural unit (A) derived from a polymerizable monomer (a) having a silicon atom-containing group represented by the following formula (1):




[in the formula (1), R1, R2, and R3 each independently represent a hydrocarbon group having a carbon number of 1 to 6]; and
a structural unit (B) derived from a polymerizable monomer (b) copolymerizable with the polymerizable monomer (a),
wherein the polymerizable monomer (a) is a monomer represented by the following formula (2):




[in the formula (2), R1, R2, and R3 each independently represent a hydrocarbon group having a carbon number of 1 to 6, and R4 represents a hydrogen atom or a methyl group],
a content of the structural unit (A) is greater than or equal to 50 mass % and less than or equal to 60 mass % in 100 mass % of the copolymer,
a content of the structural unit (B) is greater than or equal to 40 mass % and less than or equal to 50 mass % in 100 mass % of the copolymer,
the structural unit (B) includes a structural unit derived from a (meth)acrylate containing an alkoxy group and/or an oxyalkylene chain in ester moiety thereof, and
an acid value derived from free carboxy group is greater than or equal to 0.1 KOHmg/g and less than or equal to 60 KOHmg/g.

US Pat. No. 11,111,404

PRINTING METHOD AND PRINTING APPARATUS

Seiko Epson Corporation


1. A printing method comprising:a white ink application step of ejecting a white ink from a printing head to apply the white ink onto a printing medium;
a non-white ink application step of ejecting a non-white ink containing a non-white coloring material from a printing head to apply the non-white ink onto the printing medium; and
a treatment liquid application step of applying a treatment liquid containing a flocculant onto the printing medium,
wherein the white ink contains a titanium oxide white pigment and inorganic fine particles having a smaller volume average particle size than the white pigment, the inorganic fine particles being selected from the group consisting of silica, alumina, zirconia, and zinc oxide.

US Pat. No. 11,111,401

LIGHT CURING MOLDING INK SET, AND METHOD FOR MANUFACTURING LIGHT CURED ARTICLE

MAXELL HOLDINGS, LTD., K...


1. A light curing molding ink set used for a manufacturing method for light curing molding using an ink-jet scheme, comprising a combination of a resin composition for a modeling material used for shaping the modeling material and a resin composition for a supporting material used for shaping the supporting material,wherein surface tension Mt (mN/m) of the resin composition for a modeling material is greater than surface tension St (mN/m) of the resin composition for a supporting material, and the surface tension Mt and the surface tension St satisfy the following (i) expression:0

US Pat. No. 11,111,400

MULTIMATERIAL POWDER WITH COMPOSITE GRAINS FOR ADDITIVE SYNTHESIS

H.E.F., Andrezieux Bouth...


1. A multimaterial powder for use in metallurgy and plasturgy, comprising:support particles having a median particle size distribution between 1 ?m and 100 ?m and functionalising particles having a median particle size distribution that is a factor of 10 to 1000 lower relative to the support particles,
the powder being characterised in that the support particles and the functionalising particles form composite grains having a core-shell structure that each have
a core formed by a support particle, and
a shell, that covers between 10 and 100% of the surface of the support particle and which is formed by at least one surface layer of the functionalising particles,
wherein the total roughness of the surface of the functionalising layer at the scale of the grain is less than 10 ?m.

US Pat. No. 11,111,399

MATERIALS AND METHODS FOR CONDUCTIVE THIN FILMS

Quirklogic, Inc., Calgar...


1. A material composition for manufacturing a translucent conductive film, comprising:a fluid;
a plurality of nanostructures disposed in the fluid, wherein the plurality of nanostructures are metal coated dielectric rods; and
a component that modifies a structure of a joint formed between at least two nanostructures of the plurality of nanostructures after the component is activated.

US Pat. No. 11,111,398

SUBSURFACE MODIFIED SILICA MATERIALS

International Business Ma...


1. An electronic article, comprising:a substrate comprising electronic components; and
a coating disposed on the substrate that contains silica particles comprising subsurface organic groups, wherein at least two of the silica particles are bonded directly to a bridging compound having the structure X2Si—R—SiX2, wherein R is selected from the group consisting of polyurethanes, and polyethers, wherein the X groups are —OH groups.

US Pat. No. 11,111,396

TRANSPARENT FILMS WITH CONTROL OF LIGHT HUE USING NANOSCALE COLORANTS

C3 Nano, Inc., Hayward, ...


1. A transparent conductive film comprising a substrate, a transparent conductive layer supported by the substrate, a coating and one or more nanoscale colorants, wherein a value of b* for the film is reduced at least about 0.1 units and total transmittance of visible light in percent is not decreased by more than about 2 relative to the corresponding film without the nanoscale colorants, wherein the nanoscale colorants comprise a metal nanoplate having an average thickness of no more than about 100 nanometers (nm) wherein the nanoscale colorants in a dilute dispersion have a peak absorption between 525 nm and 675 nm.

US Pat. No. 11,111,395

SURFACE STRUCTURED ARTICLES AND METHODS OF MAKING THE SAME

3M Innovative Properties ...


1. A surface structured article comprising a polymer matrix and a dispersed phase, the article having first and second opposed major surfaces, wherein the article comprises a multilayer fluoropolymer film comprising in order:a first layer comprising a first polymer, the first polymer comprising at least 35 mole percent tetrafluoroethylene comonomer, at least 15 mole percent vinylidene fluoride comonomer, and at least 5 mole percent hexafluoropropylene comonomer, based on the total mole percent of the first polymer;
a second layer comprising polyvinylidene fluoride; and
a third layer comprising a third polymer, the third polymer comprising at least 50 mole percent of a methyl methacrylate comonomer, based on the total mole percent of the third polymer, wherein at least a portion of the first major surface is a microstructured, anisotropic surface comprising features having at least one dimension in a range from 1 micrometer to 500 micrometers, wherein the dispersed phase comprises an antimicrobial material, and wherein at least a portion of the dispersed phase is present on the microstructured, anisotropic surface.

US Pat. No. 11,111,394

PRIMER COATING COMPOSITION AND METHOD FOR FORMING COATING FILM

NIPPON PAINT AUTOMOTIVE C...


1. A primer coating composition comprising:an aqueous polyolefin-based resin (A);
an aqueous epoxy resin (B);
a hydrophilicized-modified carbodiimide compound (C); and
an aqueous polyurethane resin (D),
wherein
the aqueous polyolefin-based resin (A) comprises an aqueous polypropylene-based resin having a weight-average molecular weight of 50,000 to 200,000,
a content of the hydrophilicized-modified carbodiimide compound (C) is 3 to 10 parts by mass based on 100 parts by mass of the resin solid content of the primer coating composition, and
the hydrophilicized-modified carbodiimide compound (C) is a compound represented by a formula (I), (II) or (III) below:YOCONH—X—NHCOO—Z—OCONH—X—NHCOOY??(I)

wherein Xs are each a bifunctional organic group having at least one carbodiimide group, Ys are identical or different structures each resulting from elimination of a hydroxyl group from a polyalkylene glycol monoalkyl ether, and Z is a structure resulting from elimination of a hydroxyl group from a bifunctional polyol having a number-average molecular weight of 200 to 5,000,




wherein Xs are each a bifunctional organic group having at least one carbodiimide group, Ys are identical or different structures each resulting from elimination of a hydroxyl group from a polyalkylene glycol monoalkyl ether, R0 is hydrogen, a methyl group or an ethyl group, R1 is an alkylene group having 4 or less carbon atoms, n is 0 or 1, and m is 0 to 60,YOCONH—X—NHCOOY??(III)

wherein X is a bifunctional organic group having at least one carbodiimide group, and Ys are identical or different structures each resulting from elimination of a hydroxyl group from a polyalkylene glycol monoalkyl ether.

US Pat. No. 11,111,393

THERMAL INSULATING COATING FILM AND THERMAL INSULATING PAINT COMPOSITION

DREAM MAKER 53 CORPORATIO...


1. A thermal insulating coating film, comprisinga styrene-alkyl acrylate copolymer or a butyl acrylate-styrene copolymer,
polypropylene glycol monomethyl ether,
a white pigment, and
hollow acrylic beads,
wherein the hollow acrylic beads occupy 60-80 vol % in a whole coating film, and have an average particle diameter of 10 to 40 ?m, and
the white pigment is rutile titanium dioxide, the rutile titanium dioxide is contained in an amount of 74 to 143 parts by mass with respect to 100 parts by mass of the styrene-alkyl acrylate copolymer or the butyl acrylate-styrene copolymer, and the rutile titanium dioxide has an average particle diameter of 0.1 to 10 ?m.

US Pat. No. 11,111,392

OPTICAL DEVICE WITH ANTISTATIC PROPERTY

3M Innovative Properties ...


1. An optical device comprising a first optical member having a front surface, a second optical member, and an antistatic layer disposed between the first optical member and the second optical member wherein the first optical member, the second optical member, and the antistatic layer define an optical path such that light incident to the front surface of the first optical member will pass through each of the first optical member, the second optical member, and the antistatic layer;wherein the antistatic layer is transparent and has a glass transition temperature of 20° C. or less and is the reaction product of a reaction mixture consisting essentially of photo-initiator, 2 to 90 wt. % of at least one polymerizable onium salt having a fluoroorganic anion, at least one non-onium polymerizable multifunctional (meth)acrylate monomer or oligomer and optionally at least one polymerizable monofunctional (meth)acrylate monomer or oligomer, wherein the onium salt has the formula:(R1)a-bG+[(CH2)qDR2]bX?


wherein:each R1 comprises independently an alkyl, alicyclic, aryl, alkalicyclic, alkaryl, alicyclicalkyl, aralicyclic, or alicyclicaryl moiety, wherein such moiety may comprise one or more heteroatoms such as for example, nitrogen, oxygen, or sulfur, or may comprise phosphorus, or a halogen; R1 may be cyclic or aromatic and include G+in the cycle;
G is nitrogen, sulfur, or phosphorus;
a is 3 where G is sulfur and a is 4 where G is nitrogen or phosphorous;
b is an integer of 1 to 3 where G is sulfur and b is an integer of 1 to 4 where G is nitrogen or phosphorus;
q is an integer from 1 to 4;
D is oxygen, sulfur, or NR wherein R is H or a lower alkyl of 1 to 4 carbon atoms;
R2 is a (meth)acryl; and
X?is a fluoroorganic anion which is a methide or an imide.

US Pat. No. 11,111,389

COMPOSITE PARTICLES HAVING HYDROPHILIC AND HYDROPHOBIC SURFACE COATINGS


1. A composite particle, comprising a carrier particle and an at least partial surface coating covering at least part of the carrier particle,characterised in that the carrier particle comprises a hydrophilic surface region comprising quartz and wherein the carrier particle further comprises a hydrophobic surface region comprising a layered silicate, and wherein the surface of the composite particle has at least one hydrophilic region and at least one hydrophobic region wherein quartz and layered silicate are present, grown together, to form the carrier particle.

US Pat. No. 11,111,387

LIQUID CRYSTAL ALIGNING AGENT, LIQUID CRYSTAL ALIGNMENT FILM, AND LIQUID CRYSTAL DISPLAY ELEMENT

NISSAN CHEMICAL INDUSTRIE...


1. A polymer composition, comprising:(A) a side chain polymer which is a photosensitive side chain polymer exhibiting liquid crystallinity in a predetermined temperature range and has a repeating unit comprising from 0.1 to 50 mol % of a vertically alignable group; and
(B) an organic solvent;
wherein the vertically alignable group is
at least one member selected from the group consisting of alkyl having 6 to 17 carbon atoms:
wherein component (A) comprises one or more photosensitive sidechains of the following formula:




wherein A, B, and D each independently represent a single bond, —O—, —CH2—, —COO—, —OCO—, —CONH—, —NH—CO—, —CH?CH—CO—O—, or —O—CO—CH?CH—;
S represents an alkylene group having 1 to 12 carbon atoms, and a hydrogen atom bonded thereto may be replaced with a halogen group;
T represents a single bond or an alkylene group having 1 to 12 carbon atoms, and a hydrogen atom bonded thereto may be replaced with a halogen group;
Y2 represents a group selected from the group consisting of a divalent benzene ring, a naphthalene ring, a biphenyl ring, a furan ring, a pyrrole ring, an alicyclic hydrocarbon having 5 to 8 carbon atoms, and a combination thereof, and hydrogen atoms bonded thereto may be each independently substituted with —NO2, —CN, —CH?C(CN)2, —CH?CH—CN, a halogen group, an alkyl group having 1 to 5 carbon atoms, or an alkyloxy group having 1 to 5 carbon atoms;
R represents hydroxy;
P and Q each independently represent a group selected from the group consisting of a divalent benzene ring, a naphthalene ring, a biphenyl ring, a furan ring, a pyrrole ring, an alicyclic hydrocarbon having 5 to 8 carbon atoms, and a combination thereof, and when X is CH?CH—CO—O— or —O—CO—CH?CH—, P or Q on a side to which —CH?CH— is bonded is an aromatic ring; and
l1 represents 0 or 1;
l2 represents an integer of 0 to 2;
when both l1 and l2 are 0, A also represents a single bond when T is a single bond;
when l1 is 1, B also represents a single bond when T is a single bond.

US Pat. No. 11,111,386

POLYCARBONATE-POLYORGANOSILOXANE COPOLYMER, POLYCARBONATE RESIN COMPOSITION INCLUDING SAME, AND MOLDED PRODUCT THEREOF

IDEMITSU KOSAN CO., LTD.,...


1. A polycarbonate-based resin composition, comprising:a polycarbonate-polyorganosiloxane copolymer (A) comprising polycarbonate blocks (A-1) each formed of a repeating unit represented by the following general formula (I); and
polyorganosiloxane blocks (A-2) each containing a repeating unit represented by the following general formula (II), wherein the polycarbonate-polyorganosiloxane copolymer satisfies the following expression (F1a):15?wM1??(F1a)

wherein wM1 represents an average content (mass %) of the polyorganosiloxane blocks (A-2) in polycarbonate-polyorganosiloxane copolymers each having a molecular weight determined by using a polycarbonate as a conversion reference of from 56,000 or more to 200,000 or less among polycarbonate-polyorganosiloxane copolymers obtained through separation of the polycarbonate-polyorganosiloxane copolymer by gel permeation chromatography;
an aromatic polycarbonate-based resin (B) except the polycarbonate-polyorganosiloxane copolymer (A); and
a polyester-based resin (C),
wherein the polyester-based resin (C) is blended with respect to 100 parts by mass of a total of the polycarbonate-polyorganosiloxane copolymer (A) and the aromatic polycarbonate-based resin (B), and
wherein a ratio of the polycarbonate-polyorganosiloxane copolymer (A) and the aromatic polycarbonate-based resin (B) in 100 mass % of a total amount of the polycarbonate-polyorganosiloxane copolymer (A) and the aromatic polycarbonate-based resin (B), and the polyester-based resin (C) is from 50 mass % or more to 99 mass % or less:




wherein R1 and R2 each independently represent a halogen atom, an alkyl group having 1 to 6 carbon atoms, or an alkoxy group having 1 to 6 carbon atoms, X represents a single bond, an alkylene group having 1 to 8 carbon atoms, an alkylidene group having 2 to 8 carbon atoms, a cycloalkylene group having 5 to 15 carbon atoms, a cycloalkylidene group having 5 to 15 carbon atoms, a fluorenediyl group, an arylalkylene group having 7 to 15 carbon atoms, an arylalkylidene group having 7 to 15 carbon atoms, —S—, —SO—, —SO2—, —O—, or —CO—, R3 and R4 each independently represent a hydrogen atom, a halogen atom, an alkyl group having 1 to 6 carbon atoms, an alkoxy group having 1 to 6 carbon atoms, or an aryl group having 6 to 12 carbon atoms, and “a” and “b” each independently represent an integer of from 0 to 4.

US Pat. No. 11,111,382

EPOXY RESIN COMPOSITION

SUMITOMO SEIKA CHEMICALS ...


1. An epoxy resin composition comprising an epoxy resin and a polyphenylene ether, the epoxy resin being represented by the formula (1):




wherein X ring is a saturated hydrocarbon ring or an unsaturated hydrocarbon ring, or rings having a structure in which 2 to 6 saturated hydrocarbon rings and/or unsaturated hydrocarbon rings are condensed, or in which 2 saturated hydrocarbon rings and/or unsaturated hydrocarbon rings are connected;RXa, RXb, RXc, and RXd are the same or different, and each is a hydrogen atom, a lower alkyl group, a lower alkoxy group, a lower alkenyl group, a halogen atom, or a group represented by the formula (3):





wherein R1 is the same or different, and is a C1-18 alkyl group, a C2-9 alkenyl group, a cycloalkyl group, an aryl group, or an aralkyl group, wherein one or more carbon atoms of these groups may be replaced by at least one atom selected from the group consisting of an oxygen atom and a nitrogen atom;R2 is a C1-18 alkylene group, wherein one or more carbon atoms of this group other than a carbon atom directly bonded to a silicon atom may be replaced by at least one atom selected from the group consisting of an oxygen atom and a nitrogen atom;
R3 is the same or different, and is a C1-18 alkyl group, a C2-9 alkenyl group, a cycloalkyl group, an aryl group, or an aralkyl group, wherein one or more carbon atoms of these groups may be replaced by at least one atom selected from the group consisting of an oxygen atom and a nitrogen atom;
m is an integer of 0 to 6; and
n is an integer of 0 to 3;
provided that at least one of RXa, RXb, RXc, and RXd is a group represented by the formula (3); and
one or more hydrogen atoms bonded to one or more carbon atoms that constitute the hydrocarbon ring constituting the X ring, and that are not bonded to RXa, RXb, RXc, or RXd, may be replaced by a lower alkyl group, a lower alkoxy group, a lower alkenyl group, or a halogen atom.

US Pat. No. 11,111,378

BULK TRANSIENT MATERIALS MADE OF CYCLIC POLY(PHTHALALDEHYDE)

The Board of Trustees of ...


1. A composition, comprising:cyclic poly(phthalaldehyde) (cPPA);
a Lewis acid catalyst in an amount of less than about 10 ?mol/g; and
a plasticizer.

US Pat. No. 11,111,375

COMPOSITIONS AND METHODS FOR GENERATING OLIGODENDROCYTE PRECURSORS

The Regents of the Univer...


1. A three-dimensional culture system comprising:a) biocompatible thermoresponsive polymer that forms a hydrogel at 37° C.; and
b) a combination of factors that promote differentiation of oligodendrocyte precursors from pluripotent stem cells in 20 days or less, wherein the combination of factors consists of a Sonic hedgehog (Shh) signaling pathway agonist and retinoic acid (RA); and
wherein the thermoresponsive polymer comprises:
an N-isopropylacrylamide co-monomer;
an alkyl [meth]acryl[ate/amide] co-monomer, wherein the alkyl is a lower alkyl group;
a PEG acrylamide co-monomer; and
a modifying acryl[ate/amide] co-monomer comprising a linked functional group or a linked modifying agent,
wherein the thermoresponsive polymer is described by formula (II):




wherein:
a, b, c and d are molar fractions of the co-monomers, wherein a >0.8, 0.1>b>0, and 0.2>c>0;
PEGn is a polyethylglycol polymer;
Z2 is a functional group or a linked modifying agent;
L is a linker;
R1 is a lower alkyl;
G1 and G2 are each independently selected from a polymer segment, a terminal group, a linker and a linked modifying agent.

US Pat. No. 11,111,374

MULTIVALENT CATION-CONTAINING COPOLYMER, PROCESS FOR PRODUCTION THEREOF AND USE THEREOF TO TREATING AQUEOUS DISPERSIONS

BASF SE, Ludwigshafen (D...


1. A multivalent cation containing copolymer, which is water-soluble and in particulate form, wherein the multivalent cation containing copolymer is derived from one or more ethylenically unsaturated acids, the copolymer having the following characteristics:(a) an intrinsic viscosity of at least about 3 dl/g when measured in 1 M NaCl solution at 25° C.;
(b) the copolymer is a reaction product of a monomer mixture comprising an ethylenically unsaturated acid in an amount in the range of from about 5% to about 65% by weight and at least one comonomer selected from the group consisting of acrylamide, methacrylamide and any mixture thereof; and
(c) a residual comonomer content is less than 1000 ppm when the comonomer is an acrylamide,
wherein the multivalent cation containing copolymer has a gel content measurement of less than 50% gel.

US Pat. No. 11,111,372

AQUEOUS BINDER COMPOSITIONS

Owens Corning Intellectua...


1. An aqueous binder composition comprising:at least one long-chain polyol having at least two hydroxyl groups and a number average molecular weight of at least 2,000 Daltons;
at least 63 wt. % of a cross-linking agent comprising at least two carboxylic acid groups, based on the total solids content of the aqueous binder composition; and
a short-chain polyol having at least two hydroxyl groups and a number average molecular weight less than 2,000 Daltons; and
a catalyst,
wherein said binder composition has a pH after cure between 5 and 9 and achieves a b* color value, using L*a*b* coordinates, of less than 45.

US Pat. No. 11,111,368

MEANS FOR INCREASING THE MOLECULAR WEIGHT AND DECREASING THE DENSITY OF ETHYLENE INTERPOLYMERS EMPLOYING HOMOGENEOUS AND HETEROGENEOUS CATALYST FORMULATIONS

NOVA Chemicals (Internati...


1. A polyethylene film comprising at least one layer, wherein the layer comprises at least one ethylene interpolymer product comprising:(i) a first ethylene interpolymer;
(ii) a second ethylene interpolymer, and;
(iii) optionally a third ethylene interpolymer;

wherein the ethylene interpolymer product has:a dimensionless Long Chain Branching Factor, LCBF, greater than or equal to about 0.001;
from about 0.0015 ppm to about 2.4 ppm of hafnium;
has from about 0.1 ppm to about 11.4 ppm of titanium; and
has a density from about 0.862 to about 0.975 g/cc; wherein density is measured according to ASTM D792.

US Pat. No. 11,111,363

ARTICLES FORMED WITH RENEWABLE AND/OR SUSTAINABLE GREEN PLASTIC MATERIAL AND CARBOHYDRATE-BASED POLYMERIC MATERIALS LENDING INCREASED STRENGTH AND/OR BIODEGRADABILITY

BIOLOGIQ, INC., Idaho Fa...


1. An article comprising:at least one of biopolyethylene or biopolypropylene; and
a starch-based polymeric material configured to provide the at least one of biopolyethylene or biopolypropylene with biodegradability, where the at least one of biopolyethylene or biopolypropylene itself is not otherwise substantially biodegradable;
wherein the starch-based polymeric material is formed from a plasticizer and one or more starches comprising one or more of potato starch, corn starch or tapioca starch, the starch-based polymeric material has a crystallinity of less than about 20%, and does not re-form a crystalline structure, and has a water content of no more than about 2%, and
wherein the starch-based polymeric material and at least one of biopolyethylene or biopolypropylene exhibit a substantial lack of sea-island features when blended together to form the article;
wherein at least 25% of the biopolyethylene or biopolypropylene biodegrades within 5 years under ASTM D-5511.

US Pat. No. 11,111,358

STABILIZER COMPOUNDS

SOLVAY SPECIALTY POLYMERS...


1. Stabilizer compounds (SC) of formula (I) or formula (II):



wherein RJ is selected from the group consisting of —H, —CH3, —CH2CH3, —OCH3, and —OCH2CH3, and
wherein each of RK, equal or different from each other and from RJ, is selected from the group consisting of:




wherein RL is a monovalent substituent of general formula (Y-I):




wherein Ri and Rm are the same or different from each other and are independently selected from the group consisting of H,
and alkyl groups of formula —CH3, —CH2OCH3 and





andwherein Ri is either in an ortho, meta or para position, and
wherein Rm is either in an ortho or meta position, and
wherein Q is —SO2—, and
wherein RN is a divalent substituent selected from the group consisting of general formula (Z-I):




wherein Ri and Rm are the same or different from each other and are independently selected from the group consisting of —H,
alkyl groups of formula —CH3, —CH2OCH3 and




wherein Ri and Rm are independently either in an ortho or meta position, and
wherein Q is —SO2—.

US Pat. No. 11,111,353

POROUS-OBJECT PRODUCTION METHOD

DIC CORPORATION, Tokyo (...


1. A method for producing a porous material, the method comprising processing a urethane resin composition comprising a urethane resin (A) and a solvent (B) by a wet film forming process,the solvent (B) satisfying the following conditions:
a difference between a Hansen solubility parameter of the solvent (B) (B-HSP) and a Hansen solubility parameter of the urethane resin (A) (A-HSP) is in the range of 3 to 8 (J/cm3)1?2 and
a difference between the Hansen solubility parameter of the solvent (B) (B-HSP) and a Hansen solubility parameter of water (W-HSP) is in the range of 31.5 to 38 (J/cm3)1/2.

US Pat. No. 11,111,350

METHOD FOR PRODUCTION OF LOW DENSITY POLYESTER FOAM AND ARTICLES MADE THEREOF UTILIZING LOW I.V. POLYESTER FEEDSTOCK

WRH TECHNOLOGY, LLC, Mat...


1. A method for producing a polyester foam comprising:providing a low intrinsic viscosity raw material, the low intrinsic viscosity raw material includes between 25% to 100% of a post consumer polyester, and the post consumer polyester has an intrinsic viscosity of less than 0.8 dl/g;
increasing the intrinsic viscosity of the low intrinsic viscosity raw material via a de-condensation reaction configured to support foaming, wherein the intrinsic viscosity of the low intrinsic viscosity raw material is increased to 1.1 dl/g or greater;
creating a starting formulation including the low intrinsic viscosity raw material with the increased intrinsic viscosity;
foaming the starting formulation to create the polyester foam;
wherein, the polyester foam produced has a specific gravity of less than 0.65 g/cc.

US Pat. No. 11,111,348

METHOD FOR TREATING SURFACE OF RESIN MATERIAL LAYER AND RESIN MATERIAL

MITSUBISHI HEAVY INDUSTRI...


1. A method for treating a surface of a resin material layer, the method comprising a first step of introducing as a substituent a compound for substitution reaction that is at least one selected from the group consisting of an acid halide and an alkyl halide into an aromatic polyether-based resin included in the resin material layer by Friedel-Crafts reaction.

US Pat. No. 11,111,347

ORGANIC LIGHT EMITTING DEVICE AND MANUFACTURING METHOD THEREOF

Samsung Display Co., Ltd....


1. A method for manufacturing an organic light emitting device, comprising:forming an organic light emitting display panel comprising a flexible substrate provided on a support substrate, an organic light emitting element on the flexible substrate, and a thin film encapsulating film covering the organic light emitting element;
detaching the support substrate from the organic light emitting display panel;
attaching a bottom protecting film to a bottom of the organic light emitting display panel, the bottom protecting film comprising a light blocking layer for blocking external light and an adhesive layer being between the light blocking layer and the flexible substrate; and
cutting the organic light emitting display panel into a plurality of organic light emitting devices,
wherein the bottom protecting film further comprises a carrier film, and a first electricity removing layer configured to remove static electricity and being between the flexible substrate and the adhesive layer, and
wherein the adhesive layer is on the carrier film.

US Pat. No. 11,111,345

PREPREG AND CARBON FIBER-REINFORCED COMPOSITE MATERIAL

TORAY INDUSTRIES, INC., ...


1. A prepreg comprising:sizing agent-coated carbon fiber bundles coated with a sizing agent; and
a thermosetting resin composition impregnated into the sizing agent-coated carbon fiber bundles,

whereinthe sizing agent includes an aliphatic epoxy compound (A) and an aromatic compound (B) at least containing an aromatic epoxy compound (B1),
the aliphatic epoxy compound (A) and the aromatic epoxy compound (B1) are contained in a mass ratio of 52/48 to 80/20,
the aliphatic epoxy compound (A) comprises a glycidyl ether epoxy compound obtained by reaction of epichlorohydrin with a polyol selected from ethylene glycol, diethylene glycol, triethylene glycol, tetraethylene glycol, polyethylene glycol, propylene glycol, dipropylene glycol, tripropylene glycol, tetrapropylene glycol, polypropylene glycol, trimethylene glycol, 1,2-butanediol, 1,3-butanediol, 1,4-butanediol, 2,3-butanediol, polybutylene glycol, 1,5-pentanediol, neopentyl glycol, 1,6-hexanediol, 1,4-cyclohexanedimethanol, glycerol, diglycerol, polyglycerol, trimethylolpropane, pentaerythritol, sorbitol, and arabitol,
the sizing agent has an epoxy equivalent of 350 to 550 g/eq,
the sizing agent-coated carbon fiber bundles have an (a)/(b) ratio of 0.50 to 0.90, where (a) is a height (cps) of a component at a binding energy (284.6 eV) assigned to CHx, C—C, and C?C and (b) is a height (cps) of a component at a binding energy (286.1 eV) assigned to C—O in a C1s core spectrum of a surface of the sizing agent applied onto the carbon fiber bundles analyzed by X-ray photoelectron spectroscopy using AlK?1,2 as an X-ray source at a photoelectron takeoff angle of 15°,
the thermosetting resin composition is an epoxy resin composition at least containingan epoxy resin (D11) of Formula (3) below and
an epoxy resin (D12) of Formula (4) below, and
the epoxy resin composition contains the epoxy resin (D11) in an amount of 25 to 50% by mass and the epoxy resin (D12) in an amount of 40 to 80% by mass relative to 100% by mass of the total epoxy resins contained,

the thermosetting resin composition includes a latent hardener which is an aromatic amine hardener (E2) that is used in combination with the sizing agent, and if the sizing agent and the aromatic amine hardener (E2) are mixed in an amine equivalent/epoxy equivalent ratio of 0.9 to form a first mixture, and the first mixture is stored in an atmosphere of 25° C. and 60% RH for 20 days, then the glass transition point of the first mixture will increase by 25° C. or less,
wherein the epoxy resin (D11) has a structure of Formula (3):




wherein in Formula (3),each of R8 and R9 is at least one selected from the group consisting of C1-4 aliphatic hydrocarbon groups, C3-6 alicyclic hydrocarbon groups, C6-10 aromatic hydrocarbon groups, halogen atoms, acyl groups, a trifluoromethyl group, and a nitro group;
n is an integer of 0 to 4;
m is an integer of 0 to 5;
when a plurality of R8s or R9s exist, R8s and R9s are each optionally the same or different; and
Z is one selected from —O—, —S—, —CO—, —C(?O)O—, —SO2—, and —C(?O)NH—); and

wherein the epoxy resin (D12) has a structure of Formula (4):




wherein in Formula (4),R10 to R13 are at least one selected from the group consisting of a hydrogen atom, C1-4 aliphatic hydrocarbon groups, alicyclic hydrocarbon groups having a carbon number of 4 or less, and halogen atoms; and
Y is one selected from —CH2—, —O—, —S—, —CO—, —C(?O)O—, —SO2—, and —C(?O)NH—.


US Pat. No. 11,111,343

GELS AND NANOCOMPOSITES CONTAINING ANFS

The Regents of the Univer...


1. A method comprising:a. preparing branched ANFs suspended in an aprotic solvent with addition of reaction media, the reaction media comprising a protic component and a base, preparing the branched ANFs leading to splitting of micro- and microscale fibers of polymers into nanofibers with branched morphology;
b. the diameter of the nanofibers not exceeding 100 nm;
c. wherein high monodispersity of the nanofibers has a diameter distribution controlled by the reaction media and such that 90% of the nanofibers are distributed within 20 nm of a mean diameter of the nanofibers;
d. wherein branching of the nanofibers is controlled by an amount of the protic component in the reaction media and/or a composition of the base such that the number of branches for each nanofiber varies between 3 and 20;
e. transforming a suspension of the branched ANFs by diffusing water, other protic solvent, or a mixture of the water and the other protic solvent, into the suspension to make a hydrogel comprising the branched ANFs assembled into three-dimensional percolated networks (3DPNs);
f. wherein transforming the suspension comprises extruding the hydrogel or the suspension of the branched ANFs to form a manifestation of moldable 3DPNs based on the branched ANFs;
g. transforming the hydrogel into an aerogel;
h. molding of the aerogel into a shape during or after transformation from the hydrogel; and
i. incorporating polymeric and nanoscale components into the hydrogel or the aerogel.

US Pat. No. 11,111,342

POLYUREA-URETHANE CORD TREATMENT FOR POWER TRANSMISSION BELT AND BELT

Gates Corporation, Denve...


1. A power transmission belt comprising: an elastomeric body, and a tensile cord embedded in the elastomeric body;with the tensile cord impregnated with a polyurea-urethane composition different from said elastomeric body, said said polyurea-urethane composition consisting of the polyurea reaction product of:
a polyurethane prepolymer; and
a curative selected from the group consisting of diamines and water;

said tensile cord obtained by impregnation with said polyurethane prepolymer and said curative, followed by reaction to form said polyurea reaction product, optionally in the presence of non-reactive ingredients.

US Pat. No. 11,111,339

POLYACRYLATE SALT, METHODS OF PREPARATION AND APPLICATIONS FOR EMPLOYING THE SAME

Momentive Performance Mat...


1. A composition comprising a crosslinked polyacrylate salt obtained by the steps of(a) reacting a crosslinked polyacrylic polymer and an aminosilicone copolymer in the presence of a reaction-promoting amount of water in the range of 0.2 to 0.99 wt % based on the total weight of the intermediate wax composition at a temperature range of from 90 to 120° C. for a reaction time of from 4 to 6 hours to obtain an intermediate wax composition; and
(b) reacting the intermediate wax composition with an aqueous solution of an organic amine base solution to produce the crosslinked polyacrylate salt,

whereinthe crosslinked polyacrylate salt has a backbone represented by the general formula:





whereinR is selected from the group consisting of hydrogen, alkyl group, aryl group, alkaryl/aralkyl groups, and cycloaliphatic groups,
R? is selected from the group consisting of alkyl group, aryl group and alkyl/aryl groups having from 1 to 30 carbon atoms,
X? is a cationic amine group of the aminosilicone copolymer,
Y? is a cationic amine group of the organic amine base of tromethamine,
x is an integer between 50 and 20,000;
y is an integer between 50 and 20,000;
z is an integer between 0 and 5,000; and,
the ratio of x:(x+y) is between 0.02 and 0.2,

whereinthe aminosilicone copolymer is selected from the group consisting of

(i) an aminosilicone copolymer resulting from the epoxy ring opening reaction of:R1R2NH and





whereinR1 is —R3(OCH2CH2)a[OCH(CH3)CH2]m—,
R2 is H,
R3 is (CnH2n+1)— where n is an integer from 1 to 30, or (Cn?H2n??1)— where n? is an integer from 2 to 30, or (Cn?H2n??3)— where n? is an integer from 4 to 30,
a is an integer from 2 to 4,
m is 0 or an integer from 1 to 100,
and
p is an integer from 2 to 1,000;

(ii) a block copolymer having the general formula of [AB]n
whereinA is a polysiloxane group having the general formula of[X(CaH2aO)bR6[(SiO(R5)2]cSi(R5)2R6(OCaH2a)bX],

B is a polyalkyleneoxide group having the general formula of[YO(CaH2aO)dY],

R5 is an alkyl containing from 1 to 4 carbon atoms,
R6 is a divalent organic moiety,
X and Y are divalent organic groups selected from a secondary or tertiary amine and a ring opened epoxide, such that when X is a ring opened epoxide, Y is an amine and vice versa,
a is independently 2 to 4,
b is independently 0 to 100,
c is 1 to 500,
d is 0 to 100,
n is an integer from 1 to 500, and
(b+d) is 1 to 100; and,

(iii) a random copolymer of C and D
whereinC is a polysiloxane group having the general formula:—CR7R8—CR9(OH)R11—(SiR102O)x—SiR102—R11CR9(OH)CR7R8-L-


whereinR7 is independently selected from the group consisting of hydrogen and alkyl, aryl, alkenyl, or aralkyl group containing up to 20 carbon atoms, and optionally containing an oxygen atom,
R8 is independently selected from the group consisting of a bond, hydrogen and an alkyl, aryl, alkenyl, or aralkyl group containing up to 20 carbon atoms, and optionally containing an oxygen atom,
R9 is independently selected from the group consisting of hydrogen, and an alkyl, aryl, alkenyl, or aralkyl group containing up to 20 carbon atoms, and optionally containing an oxygen atom,
with the proviso that if R8 is a chemical bond, then R9 is a divalent hydrocarbon group of from 1 to 20 carbon atoms, and optionally containing an oxygen atom, that form a ring containing the chemical bond, R8,
R10 is independently selected from the group consisting of hydrogen, and an alkyl, alkenyl, aryl or aralkyl group containing up to 10 carbon atoms,
R11 is a divalent hydrocarbon radical containing from 1 to 20 carbon atoms, and optionally containing an oxygen atom,
L is independently a divalent linking group selected from the group consisting of —N(R12NR132)— and





whereinR12 is a divalent hydrocarbon radical containing from 1 to 20 carbon atoms,
R13 is independently hydrocarbon radical containing from 1 to 20 carbon atoms, and
R14 is a divalent hydrocarbon group containing from 2 to 20 carbon atoms, and optionally containing an oxygen atom or an —NR13— group,
x is an integer from 1 to 500, and
D is a polyalkylene oxide having the general formula of—CR7R8—CR9(OH)R11—O(CaH2aO)bR11C—R9(OH)CR7R8-L-


wherein R7, R8, R9, R11, L, a and b are defined as above,
wherein the obtained crosslinked polyacrylate salt has a Brookfield viscosity at 25° C. in the range of 15,000 to 50,000 cp when diluted at 3 wt % in water.

US Pat. No. 11,111,338

TERMINAL-FUNCTIONALIZED POLYMER AND RELATED METHODS

Bridgestone Corporation, ...


1. A rubber composition comprising:10-100 phr of a terminal-functionalized polymer having the following formula (II):




wherein P is a polymer chain comprising at least one type of conjugated-diene monomer;
Ra and Rc are the same or different and each is independently selected from vinyl-containing groups,
Rb is selected from:(i) an alkyl group having 1 to 20 carbons,
(ii) a cycloalkyl group having 3 to 20 carbons, and
(iii) an alkylaryl group having 7 to 20 carbons; and

n is 2 to 20;
silica filler;
no more than about 10 phr of oil;
and a cure package.

US Pat. No. 11,111,337

POLYORGANOSILSESQUIOXANE, HARD COAT FILM, ADHESIVE SHEET, AND LAMINATE

DAICEL CORPORATION, Osak...


1. A hard coat layer comprising a cured product of a curable composition comprising a polyorganosilsesquioxane,the polyorganosilsesquioxane comprising:a constitutional unit represented by Formula (I); and
a constitutional unit represented by Formula (II), in a mole ratio of the constitutional unit represented by Formula (I) to the constitutional unit represented by Formula (II) of from 5 to 18,a constitutional unit represented by Formula (2), and
an optional constitutional unit represented by Formula (5),


the polyorganosilsesquioxane having a total proportion of the constitutional unit represented by Formula (I) and a constitutional unit represented by Formula (II) of 95% to 99% by mole based on a total amount (100% by mole) of all siloxane constitutional units,
the polyorganosilsesquioxane having a total proportion of the constitutional unit represented by Formula (2) and a constitutional unit represented by Formula (5) of 1% to 5% by mole based on a total amount (100% by mole) of all siloxane constitutional units,
the polyorganosilsesquioxane having a number-average molecular weight of 1100 to 2600 and a molecular-weight dispersity (weight-average molecular weight to number-average molecular weight ratio) of 1.1 to 2.0,
Formulae (I), (II), (2), and (5) expressed as follows:[RaSiO3/2]??(I)

wherein Ra is selected from:a group represented by Formula (1a);
a group represented by Formula (1d),

Formulae (1a) and (1d) expressed as follows:




wherein R1a represents an ethylene group,




wherein R1d represents an ethylene group,[RbSiO(ORc)]??(II)

wherein Rb is selected from:a group represented by Formula (1a); and
a group represented by Formula (1d),

Formulae (1a) and (1d) expressed as follows:




wherein R1a represents an ethylene group,




wherein R1d represents an ethylene group;
and Rc is selected from a hydrogen atom and a C1-C4 alkyl group,[R2SiO3/2]??(2)

wherein R2 is an unsubstituted phenyl group, and[R2SiO(ORc)]??(5)

wherein R2 is as defined in Formula (2); and Rc is as defined in Formula (II).

US Pat. No. 11,111,335

METHOD OF PREPARING CARBOXYLIC ACID FUNCTIONALIZED POLYMERS

Nektar Therapeutics, San...


1. A method of preparing a carboxylic-acid functionalized methoxypolyethylene glycol (m PEG), comprising:(i) reacting, in an organic solvent, a two-fold up to a 30-fold molar excess of a tertiary ester reagent having a structure,




?where X is a halo group, and each of R3, R4 and R5 is phenyl, with a methoxyPEG-OH (mPEG-OH) having a molecular weight selected from 10,000 Da, 15,000 Da, 20,000 Da, 25,000 Da, 30,000 Da and 40,000 Da, in the presence of base at a temperature of about 25-50° C., to thereby form a reaction mixture comprising a mPEG-tertiary ester having a structure,




(ii) removing the organic solvent from the reaction mixture by distillation to provide a residue comprising the mPEG-tertiary ester,
(iii) hydrolyzing the mPEG-tertiary ester by addition of a strong base in aqueous solution to the residue from (ii) to thereby form a mPEG-carboxylate salt,
(iv) directly treating, without further isolation, the mPEG carboxylate salt from (iii) with aqueous inorganic acid to thereby provide a reaction mixture comprising a carboxylic acid-functionalized mPEG having a structure, mPEG-OCH2C(O)OH, and
(v) isolating the carboxylic acid-functionalized mPEG from the reaction mixture, wherein the isolated carboxylic acid-functionalized mPEG contains less than 5% by weight of mPEG-OH, wherein no trifluoroacetic acid is used in the process and the methoxyPEG-OH is branched.

US Pat. No. 11,111,334

POLYMERIZABLE COMPOSITIONS COMPRISING NITRO SUBSTITUTED POLYESTER DIOLS

BioCellection Inc., Menl...


1. A composition comprising a compound of the formula:



wherein n is 0-14, y is 1-100, X is either H or NO2, R is an aliphatic, cycloaliphatic, aromatic, or oligoether linker, and R? is H or a photopolymerizable group, wherein at least one X is NO2; and further comprising a compound of the formula:




wherein n is 0-14, y is 1-100, R is an aliphatic, cycloaliphatic, aromatic, or oligoether linker, and R? is H or a photopolymerizable group.

US Pat. No. 11,111,333

RESIN COMPOSITIONS AND RESIN INFUSION PROCESS

Cytec Industries Inc., P...


1. A curable epoxy resin composition suitable for liquid resin infusion, comprising:(A) a combination of polyepoxides consisting of: (i) triglycidyl ether of tris(hydroxyphenyl)-methane represented by Formula I:




(ii) diglycidyl ether of Bisphenol F or Bisphenol A;
(iii) a difunctional epoxide represented by the following Formula II:





and(iv) an epoxy novolac resin represented by the following Formula III:





where n=1 to 5, and R=H(B) 9,9-bis(4-amino-3-chlorophenyl)fluorene and/or 9,9-bis(4-aminophenyl)fluorene; and
(C) core-shell rubber particles,
wherein the weight percentages of the polyepoxides, based on the total weight of the epoxy resin composition, are as follows: 2% to 10% polyepoxide (i); 24% to 38% polyepoxides (ii) and (iii) combined; and 1% to 7% polyepoxide (iv),
wherein the molar ratio of component (B) to component (A) is 1:1 to 2:1,
wherein the amount of core-shell rubber particles is in the range of 0.3% to 10% by weight, based on the total weight of the epoxy resin composition, and
wherein the curable epoxy resin composition is void of any thermoplastic polymer.

US Pat. No. 11,111,332

ISOCYANATE POLYMERIZATION CATALYST, PREPARATION METHOD THEREOF, AND METHOD FOR PREPARING POLYISOCYANATE BY USING SAME

Wanhua Chemical Group Co....


1. A catalyst for the polymerization of isocyanates, wherein the catalyst has a structural formula represented by formula I:



wherein, Y is a residue of a hydroxyl-containing aromatic heterocyclic compound;
wherein, R1, R2 and R3 are independently selected from alkyls having 1-20 carbon atoms, cycloalkyls having 4-15 carbon atoms, aralkyls having 7-15 carbon atoms, aryls having 6-15 carbon atoms, or R1 and R2 together form a ring structure having 4-6 carbon atoms, the ring structure formed by R1 and R2 optionally contains a N heteroatom and/or a 0 heteroatom in the ring structure; and R is selected from hydrogen or alkyls having 1-10 carbon atoms.

US Pat. No. 11,111,329

PREPARATION OF AN AQUEOUS DISPERSION OF COPOLYMER PARTICLES OF VINYL ACETATE AND A CYCLIC KETENE ACETAL MONOMER

Rohm and Haas Company, C...


1. A method for preparing an aqueous dispersion of vinyl acetate-cyclic ketene acetal copolymer particles comprising the steps of:a) contacting under emulsion polymerization conditions at a temperature in the range of from 30° C. to 55° C., and at a pH in the range of from 6.0 to 9.0:1) 75 to 98.5 parts by weight of vinyl acetate;
2) 1 to 20 parts by weight of a cyclic ketene acetal monomer; and
3) 0.05 to 5 parts by weight of a monoethylenically unsaturated acid monomer or a salt thereof; to form an aqueous dispersion of copolymer particles comprising structural units of vinyl acetate, the cyclic ketene acetal, and the monoethylenically unsaturated acid monomer or a salt thereof;

wherein the cyclic ketene acetal monomer is the following structure:




where n is 0, 1, or 2;
R is H or C1-C6-alkyl;
R1 and R2 are each independently H, C1-C12-alkyl, phenyl, or vinyl; or R1 and R2 together with the carbon atoms to which they are attached, form a fused benzene ring or a fused C3-C7 cycloaliphatic ring; and
R1? and R2? are each independently H or C1-C12-alkyl; or R1 and R1? and/or R2 and R2? form an exocyclic double bond;
with the proviso that when n is 1:
R3 and R3? are each independently H, C1-C12-alkyl, phenyl, or R3 and R3? form an exocyclic double bond or a spirocycloaliphatic group or spiro-2-methylene-1,3-dioxepane group;
with the proviso that when n is 2:
each R3 is H, C1-C2-alkyl, or together with the carbon atoms to which they are attached form a double bond, a fused benzene ring, or a fused C3-C7-cycloaliphatic ring.

US Pat. No. 11,111,328

AQUEOUS DISPERSION OF COPOLYMER PARTICLES OF VINYL ACETATE AND A CYCLIC KETENE ACETAL MONOMER

Rohm and Haas Company, C...


1. A composition comprising an aqueous dispersion of copolymer particles having a z-average particle size in the range of from 50 nm to 500 nm, which polymer particles comprise, based on the weight of the copolymer particles, a) from 75 to 98.5 weight percent structural units of vinyl acetate; b) from 1 to 20 weight percent structural units of a cyclic ketene acetal monomer; and c) from 0.05 to 5 weight percent structural units of a monoethylenically unsaturated acid monomer, or a salt thereof; wherein the cyclic ketene acetal monomer is characterized by following structure:



where n is 0, 1, or 2;
R is H or C1-C6-alkyl;
R1 and R2 are each independently H, C1-C12-alkyl, phenyl, or vinyl; or R1 and R2 together with the carbon atoms to which they are attached, form a fused benzene ring or a fused C3-C7-cycloaliphatic ring; and
R1? and R2? are each independently H or C1-C12-alkyl; or R1 and R1? and/or R2 and R2? form an exocyclic double bond;
with the proviso that when n is 1:
R3 and R3? are each independently H, C1-C12-alkyl, phenyl, or R3 and R3? form an exocyclic double bond or a spirocycloaliphatic group or spiro-2-methylene-1,3-dioxepane group;
with the further proviso that when n is 2:
each R3 is H, C1-C12-alkyl, or together with the carbon atoms to which they are attached form a double bond, a fused benzene ring, or a fused C3-C7-cycloaliphatic ring.

US Pat. No. 11,111,324

METHOD FOR WITHDRAWING AGGLOMERATES FROM A FLUIDIZED BED POLYMERIZATION REACTOR

Borealis AG, Vienna (AT)...


1. A method for withdrawing polymer agglomerates from a fluidised bed polymerisation reactor, the polymerisation reactor comprising a middle zone having a generally cylindrical shape, a bottom zone having a generally conical shape in direct contact with and below the middle zone and wherein a base of a fluidised bed is formed, and wherein there is no fluidisation grid in the fluidised bed reactor and an agglomerate trap below the bottom zone, the agglomerate trap having a body, a first connection comprising a first valve connecting the body to the bottom zone and a second connection comprising a second valve connecting the body to agglomerate recovery system and wherein the reactor does not comprise a fluidisation grid, the method comprising the steps of measuring a value of a process variable indicative of the content of agglomerates in the agglomerate trap; and adjusting the opening time of the first valve or the second valve or both the first valve and the second valve based on the measured value.

US Pat. No. 11,111,322

LOW DENSITY ETHYLENE-BASED POLYMERS FOR LOW SPEED EXTRUSION COATING OPERATIONS

Dow Global Technologies L...


1. A polyethylene homopolymer comprising the following properties:a) a melt index (I2) from 1.0 to 3.5 dg/min;
b) a Mw(abs) as determined by light scattering gel permeation chromatography versus I2 relationship: Mw(abs)?A+B(I2), where A=3.20×105 g/mole, and B=?8.00×103 (g/mole)/(dg/min);
c) a Mw(abs) as determined by light scattering gel permeation chromatography versus I2 relationship: Mw(abs)?C+D(I2), where C=3.90×105 g/mole, and D=?8.00×103 (g/mole)/(dg/min).

US Pat. No. 11,111,321

PHOTOCROSSLINKABLE NEUTRAL ELECTROCHROMIC POLYMERS AND METHOD FOR PREPARING SAME

AMBILIGHT INC., Grand Ca...


1. A polymer comprising a formula of:



wherein n is an integer greater than 0; x is an integer greater than 0; y is an integer greater than 0;
z is an integer greater than 0; M is a monomer unit; and each of R1, R2, R3 and R4 is independently selected from one of hydrogen, C1-C30 alkyl, C2-C30 alkenyl, C2-C30 alkynyl, C2-C30 alkylcarbonyl, C1-C30 alkoxy, C1-C30 alkoxyalkyl, or C2-C30 alkoxycarbonyl; and
wherein M is selected from a group including:




wherein the wavy line represents a single covalent bond, and each of R5, R6, R7, R8, R9, R10, R11, and R12 is independently selected from one of hydrogen, C1-C30 alkyl, C2-C30 alkenyl, C2-C30 alkynyl, C2-C30 alkylcarbonyl, C1-C30 alkoxy, C1-C30 alkoxyalkyl, or C2-C30 alkoxycarbonyl.

US Pat. No. 11,111,320

ADDITION-FRAGMENTATION OLIGOMERS

3M Innovative Properties ...


1. A polymerizable composition comprising:an addition-fragmentation oligomer;
at least one free-radically polymerizable monomer; and
an initiator,
wherein the addition-fragmentation oligomer is of the formula:




wherein
RA is non-directionally a 1-methylene-3,3-dimethyl propyl group,
RB is a hydrocarbyl group, wherein at least two RA and/or RB groups are substituted with a pendent functional group D that bonds or etches a substrate to which it adheres;
X1 is —O— or NR5—, where R5 is H or C1-C4 alkyl;
Z comprises an ethylenically unsaturated polymerizable group;
y is 0 or 1; and
x is 0 to 60,
wherein the D group that bonds or etches a substrate is selected from monophosphate, phosphonate, phosphonic acid, hydroxamic acid, carboxylic acid, acetoacetate, anhydride, isonitrile, silyl, disulfide, thiol, amino, sulfinic acid, sulfonic acid, and phosphine groups.

US Pat. No. 11,111,318

SILYL-BRIDGED BIS-BIPHENYL-PHENOXY CATALYSTS FOR OLEFIN POLYMERIZATION

Dow Global Technologies L...


1. A polymerization process for producing an ethylene-based polymer comprising:polymerizing ethylene and at least one additional ?-olefin in the presence of a catalyst system, wherein the catalyst system comprises a pro-catalyst defined by the metal ligand complex of formula (I):





where:M is titanium, zirconium, or hafnium, each independently being in a formal oxidation state of +2, +3, or +4; and n is an integer of from 0 to 3, and wherein when n is 0, X is absent; and
each X independently is a monodentate ligand that is neutral, monoanionic, or dianionic; or two Xs are taken together to form a bidentate ligand that is neutral, monoanionic, or dianionic;
the metal ligand complex of formula (I) is, overall, neutral;
each Z independently is O;
R1-7 and R10-16 are selected from the group consisting of a (C1-C40)hydrocarbyl, (C1-C40)heterohydrocarbyl, —Si(RC)3, halogen atom, hydrogen atom, and combinations thereof;
R8 and R9 are hydrogen atoms;
R23 and R24 are —CH2—;
R17-22 are independently selected from a hydrogen atom and a (C1-C40)hydrocarbyl, wherein the sum of the non-hydrogen atoms for R17-19 is larger than 1, and/or the sum of the non-hydrogen atoms for R20-22 is larger than 1 and optionally two or more groups selected from R17-22 can combine together to form a ring structure, with such ring structures having from 3 to 50 atoms in the ring, excluding any hydrogen atoms;
at least one of R1 and R16 or both of R1 and R16 radicals selected from formula (II), formula (III), and formula (IV):




R31-35, R41-44, and R51-59 are independently chosen from a (C1-C40)hydrocarbyl, (C1-C40)heterohydrocarbyl, —Si(RC)3, halogen atom, hydrogen atom, and combinations thereof; and
each RC is independently selected from (C1-C30)hydrocarbyl.

US Pat. No. 11,111,273

CYCLIC PEPTIDES MULTIMERS TARGETING ALPHA-4-BETA-7 INTEGRIN


1. A homodimer of two moieties covalently linked together by an amide bond to a diphenic acid residue, the moieties both being of formula (I):




whereinR1 is H;
R2 is H;
R3 is CH3;
R4 is H;
R5 is an amide of the formula —C(O)NR**R***, wherein R** is H and R*** is tert-butyl;
R6 along with R7 together form the pyrrolidine ring of Pro;
R8 is H;
n is 1;
wherein Z is an amino terminus of an amino acid; —C?O— adjacent L is the carboxy terminus of an amino acid; and L along with Z and —C?O— is a peptide having the following formula:Xy—Xz—X1—X2—X3


whereinXy is 3-aminomethyl-4-[4-(1-piperazinyl)-phenyl]-benzoic acid, in which the piperazinyl amine nitrogen at the 4-position of the piperazinyl ring is covalently bound via the amide bond to the diphenic acid residue to form the homodimer;
Xz is absent;
X1 is Leucine;
X2 is Asp; and
X3 is Thr;

or a pharmaceutically acceptable salt thereof.

US Pat. No. 11,111,270

INHIBITOR OF APOPTOSIS PROTEIN (IAP) ANTAGONISTS

SANFORD BURNHAM PREBYS ME...


1. A compound having the structure of Formula C-I, pharmaceutically acceptable salt, N-oxide, racemate, or stereoisomer thereof:



wherein,
R1 is H, C1-C6alkyl, C3-C6cycloalkyl, —C1-C6alkyl-(substituted or unsubstituted C3-C6cycloalkyl), substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, —C1-C6alkyl-(substituted or unsubstituted aryl), or —C1-C6alkyl-(substituted or unsubstituted heteroaryl);
X1 is N—RA;
X2 is CR2cR2d;
X3 is CR2aR2b;
RA is H, C1-C6alkyl, —C(?O)C1-C6alkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
W1 is O, S, N—Ra, or C(R8a)(R8b);
W2 is O, S, N—Ra, or C(R8c)(R8d); provided that W1 and W2 are not both O, or both S;
R2a, R2b, R2c, and R2d are independently selected from H, substituted or unsubstituted C1-C6alkyl, substituted or unsubstituted C3-C6cycloalkyl, substituted or unsubstituted C2-C5heterocycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, —C1-C6alkyl-(substituted or unsubstituted C3-C6cycloalkyl), —C1-C6alkyl-(substituted or unsubstituted C2-C5heterocycloalkyl), —C1-C6alkyl-(substituted or unsubstituted aryl), —C1-C6alkyl-(substituted or unsubstituted heteroaryl), and —C(?O)RB;
RB is substituted or unsubstituted C1-C6alkyl, substituted or unsubstituted C3-C6cycloalkyl, substituted or unsubstituted C2-C5heterocycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, —C1-C6alkyl-(substituted or unsubstituted C3-C6cycloalkyl), —C1-C6alkyl-(substituted or unsubstituted C2-C5heterocycloalkyl), —C1-C6alkyl-(substituted or unsubstituted aryl), —C1-C6alkyl-(substituted or unsubstituted heteroaryl), or —NRDRE;
RD and RE are independently selected from H, substituted or unsubstituted C1-C6alkyl, substituted or unsubstituted C3-C6cycloalkyl, substituted or unsubstituted C2-C5heterocycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, —C1-C6alkyl-(substituted or unsubstituted C3-C6cycloalkyl), —C1-C6alkyl-(substituted or unsubstituted C2-C5heterocycloalkyl), —C1-C6alkyl-(substituted or unsubstituted aryl), and —C1-C6alkyl-(substituted or unsubstituted heteroaryl);
m is 0, 1, or 2;
—U— is —NHC(?O)—, —C(?O)NH—, —NHS(?O)2—, —S(?O)2NH-, —NHC(?O)NH—, —NH(C?O)O-, —O(C?O)NH-, or —NHS(?O)2NH-;
R3 is C1-C3alkyl or C1-C3fluoroalkyl;
R4 is —NHR5, —N(R5)2, —N+(R5)3, or —OR5;
each R5 is independently selected from H, C1-C3alkyl, C1-C3haloalkyl, and —C1-C3alkyl-(C3-C5cycloalkyl);
or:
R3 and R5 together with the atoms to which they are attached form a substituted or unsubstituted 5-7 membered ring;
or:
R3 is bonded to a nitrogen atom of U to form a substituted or unsubstituted 5-7 membered ring;
R6 is —NHC(?O)R7, —C(?O)NHR7, —NHS(?O)2R7, —S(?O)2NHR7; —NHC(?O)NHR7, —NHS(?O)2NHR7, -(C1-C3alkyl)-NHC(?O)R7, -(C1-C3alkyl)-C(?O)NHR5, -(C1-C3alkyl)-NHS(?O)2R7, -(C1-C3alkyl)-S(?O)2NHR7; -(C1-C3alkyl)-NHC(?O)NHR7, -(C1-C3alkyl)-NHS(?O)2NHR7, substituted or unsubstituted C2-C10heterocycloalkyl, or substituted or unsubstituted heteroaryl;
each R7 is independently selected from C1-C6alkyl, C1-C6haloalkyl, a substituted or unsubstituted C3-C10cycloalkyl, a substituted or unsubstituted C2-C10heterocycloalkyl, a substituted or unsubstituted aryl, a substituted or unsubstituted heteroaryl, —C1-C6alkyl-(substituted or unsubstituted C3-C10cycloalkyl), —C1-C6alkyl-(substituted or unsubstituted C2-C10heterocycloalkyl, —C1-C6alkyl-(substituted or unsubstituted aryl), —C1-C6alkyl-(substituted or unsubstituted heteroaryl), —(CH2)P—CH(substituted or unsubstituted aryl)2, —(CH2)P—CH(substituted or unsubstituted heteroaryl)2, —(CH2)P—CH(substituted or unsubstituted aryl)(substituted or unsubstituted heteroaryl), -(substituted or unsubstituted aryl)-(substituted or unsubstituted aryl), -(substituted or unsubstituted aryl)-(substituted or unsubstituted heteroaryl), -(substituted or unsubstituted heteroaryl)-(substituted or unsubstituted aryl), and -(substituted or unsubstituted heteroaryl)-(substituted or unsubstituted heteroaryl);
p is 0, 1, or 2;
R8a, R8b, R8c, and R8d are independently selected from H, C1-C6alkyl, C1-C6fluoroalkyl, C1-C6 alkoxy, and substituted or unsubstituted aryl;
or:
R8a and R8d are as defined above, and R8b and R8c together form a bond;
or:
R8a and R8d are as defined above, and R8b and R8c together with the atoms to which they are attached form a substituted or unsubstituted fused 5-7 membered saturated, or partially saturated carbocyclic ring or heterocyclic ring comprising 1-3 heteroatoms selected from S, O, and N, a substituted or unsubstituted fused 5-10 membered aryl ring, or a substituted or unsubstituted fused 5-10 membered heteroaryl ring comprising 1-3 heteroatoms selected from S, O, and N;
or:
R8c and R8d are as defined above, and R8a and R8b together with the atoms to which they are attached form a substituted or unsubstituted saturated, or partially saturated 3-7 membered spirocycle or heterospirocycle comprising 1-3 heteroatoms selected from S, O, and N;
or:
R8a and R8b are as defined above, and R8c and R8d together with the atoms to which they are attached form a substituted or unsubstituted saturated, or partially saturated 3-7 membered spirocycle or heterospirocycle comprising 1-3 heteroatoms selected from S, O, and N;
where each substituted alkyl, fused ring, spirocycle, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl is substituted with 1-3 R9;
each R9 is independently selected from halogen, —OH, —SH, (C?O), CN, C1-C4alkyl, C1-C4 fluoroalkyl, C1-C4 alkoxy, C1-C4fluoroalkoxy, —NH2, —NH(C1-C4alkyl), —NH(C1-C4alkyl)2, —C(?O)OH, —C(?O)NH2, —C(?O)C1-C3alkyl, —S(?O)2CH3, —NH(C1-C4alkyl)-OH, —NH(C1-C4alkyl)-O—(C1-C4alkyl), —O(C1-C4alkyl)-NH2, —O(C1-C4alkyl)-NH—(C1-C4alkyl), and —O(C1-C4alkyl)-N—(C1-C4alkyl)2; or two R9 together with the atoms to which they are attached form a methylene dioxy or ethylene dioxy ring substituted or unsubstituted with halogen, —OH, or C1-C3alkyl;
where each heterocycloalkyl is independently selected from a monocyclic, fused bicyclic, and bridged bicyclic ring, where the heterocycloalkyl has from 2 to 10 carbons in the ring and heteroatoms selected from O, N, or S; and
where each heteroaryl is independently selected from a monocyclic and fused bicyclic ring, where the heteroaryl is a 5- to 14-membered ring system comprising one to thirteen carbon atoms, one to six heteroatoms selected from the group consisting of O, N, or S.

US Pat. No. 11,111,267

CRYSTAL FORMS OF AN ANTITUMOR AGENT AND THEIR PREPARATION METHODS

Xianchang Gong, El Cajon...


6. A crystalline form of the compound Jervine of Formula 1, wherein the crystalline form is Form II, and has an X-ray powder diffraction (XRPD) pattern comprising peaks at diffraction angle 2?(±0.20) degrees of 8.8458°, 13.3548°, 13.6199°, 14.4729°, 14.6803°, 15.0188°, 16.3034°, 17.1282°, 20.7405° and 20.9599° when irradiated with a Cu-K? light source:




US Pat. No. 11,111,266

OXYSTEROLS AND METHODS OF USE THEREOF

SAGE THERAPEUTICS, INC., ...


1. A compound of Formula (I-63):




or a pharmaceutically acceptable salt thereof, wherein:R1 is alkyl;
R2 is alkyl, alkenyl, alkynyl, carbocyclyl, heterocyclyl, aryl, or heteroaryl and R3 is hydrogen, alkyl, carbocyclyl, heterocyclyl, aryl, or heteroaryl, or
R2 and R3, together with the carbon atom to which they are attached form a 3-8 membered ring;
each of R4 and R5 is independently hydrogen, halo, or —ORC, wherein RC is hydrogen or C1-C6alkyl, or
R4 and R5, together with the carbon atom to which they are attached form an oxo group;
R6 is absent or hydrogen; and
represents a single or double bond, wherein when one of is a double bond, the other is a single bond and R6 is absent; and wherein when both of are single bonds, R6 is hydrogen.

US Pat. No. 11,111,265

METHOD FOR PREPARING CHOLIC ACID COMPOUND

CHIA TAI TIANQING PHARMAC...


1. A preparation method for a compound of formula I,




comprising the following steps:a) subjecting a compound of formula 2 to an oxidization reaction in a solvent to obtain a compound of formula 3,





b) attaching a protecting group to the compound of formula 3 in a solvent to obtain a compound of formula 4,




c) reacting the compound of formula 4 with acetaldehyde in a solvent to obtain a compound of formula 5,




d) subjecting the compound of formula 5 to a reduction reaction in a solvent under a catalyst to obtain a compound of formula 6,




e) converting cyano group of the compound of formula 6 to a carboxyl group to give the compound of formula I,




wherein, said R1 and R2 are each independently selected from a silyl ether protecting group.

US Pat. No. 11,111,263

PROCESS FOR THE MANUFACTURE OF (2S,3S,4S,5R,6S)-3,4,5-TRIHYDROXY-6-(((4AR,10AR)-7-HYDROXY-1-PROPYL-1,2,3,4,4A,5,10,10A-OCTAHYDROBENZO[G]QUINOLIN-6-YL)OXY)TETRAHYDRO-2H-PYRAN-2-CARBOXYLIC ACID


1. A process for the preparation of compound (Id) with the formula below



from compound (I) with the formula below





comprising the following stepreacting compound (I), or a salt thereof, with benzyl halogenide to obtain compound (A2) according to the reaction scheme below




wherein Ph is phenyl and X is selected from the group consisting of Cl, Br and I.

US Pat. No. 11,111,262

C-MANNOSIDE COMPOUNDS USEFUL FOR THE TREATMENT OF URINARY TRACT INFECTIONS

GlaxoSmithKline Intellect...


1. A compound which is




US Pat. No. 11,111,259

ACYLSULFONAMIDE DERIVATIVES FOR TREATING SENESCENCE-ASSOCIATED DISEASES AND DISORDERS

Unity Biotechnology, Inc....


1. A compound represented by Formula (I):




or a salt thereof, wherein:Z1 is a piperidine or piperazine substituted with —X—C1-6 alkyl-R3 and Z1 is further optionally substituted with one or more R6;
Z2 is C3-12 carbocycle optionally substituted with one or more R6;
R1 is hydrogen;
Z3 is C3-12 carbocycle optionally substituted with one or more R6;
L1 is selected from —(CH2)s—X10—(CH2)r—, —(CH2)r—X10—(CH2)r—X10—(CH2)r—, and —(CH2)r—X10—(CH2)r—X10—(CH2)r—X10—(CH2)r—, wherein s is selected from 0 to 3, each r is selected from 1 to 6, each X10 is selected from —O—, —S—, or —N(R4)—, and L1 may be optionally substituted with one or more R6;
L2 is Y-alkylene;
Y is 3- to 12-membered heterocycle;
W and W1 are independently selected from —O—, —S— and —NR10—;
R2 and R2* are independently selected from R7, or R2 and R2* are taken together with the atoms to which they are attached to form a heterocycle, optionally substituted with one or more R6;
R3 is C3-12 carbocycle or 3- to 12-membered heterocycle, each of which is optionally substituted with one or more R6;
R4 is independently selected at each occurrence from hydrogen, —C(O)R10, —C(O)OR10 and —C(O)N(R4)—; C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl, each of which is independently optionally substituted at each occurrence with one or more substituents selected from halogen, —NO2, —CN, —OR10, —SR10, —N(R10)2, —S(?O)R10, —S(?O)2R10, —S(?O)2N(R10)2, —NR10S(?O)2R10, —C(O)R10, —C(O)OR10, —OC(O)R10, —OC(O)OR10, —OC(O)N(R10)2, —NR10C(O)R10, —C(O)N(R10)2, ?O, ?S, ?N(R10), —P(O)(OR7)2, —OP(O)(OR7)2, C3-10 carbocycle and 3- to 12-membered heterocycle; and C3-12 carbocycle and 3- to 12-membered heterocycle, wherein each C3-12 carbocycle and 3- to 12-membered heterocycle in R4 is independently optionally substituted with one or more substituents selected from halogen, —NO2, —CN, —OR10, —SR10, —N(R10)2, —S(?O)R10, —S(?O)2R10, —S(?O)2N(R10)2, —NR10S(?O)2R10, —C(O)R10, —C(O)OR10, —OC(O)R10, —OC(O)OR10, —OC(O)N(R10)2, —NR10C(O)R10, —C(O)N(R10)2, ?O, ?S, ?N(R10), —P(O)(OR7)2, —OP(O)(OR7)2, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, and C2-6 alkynyl;
R6 is independently selected at each occurrence from halogen, —NO2, —CN, —OR10, —SR10, —N(R10)2, —S(?O)R10, —S(?O)2R10, —S(?O)2N(R10)2, —NR10S(?O)2R10, —C(O)R10, —C(O)OR10, —OC(O)R10, —OC(O)OR10, —OC(O)N(R10)2, —NR10C(O)R10, —C(O)N(R10)2, ?O, ?S, ?N(R10), —P(O)(OR7)2, —OP(O)(OR7)2; C1-10 alkyl, C2-10 alkenyl, and C2-10 alkynyl, each of which is independently optionally substituted at each occurrence with one or more substituents selected from halogen, —NO2, —CN, —OR10, —SR10, —N(R10)2, —S(?O)R10, —S(?O)2R10, —S(?O)2N(R10)2, —NR10S(?O)2R10, —C(O)R10, —C(O)OR10, —OC(O)R10, —OC(O)OR10, —OC(O)N(R10)2, —NR10C(O)R10, —C(O)N(R10)2, ?O, ?S, ?N(R10), —P(O)(OR10)2, —OP(O)(OR10)2, C3-12 carbocycle and 3- to 12-membered heterocycle; and C3-12 carbocycle and 3- to 12-membered heterocycle, wherein each C3-12 carbocycle and 3- to 12-membered heterocycle in R6 is independently optionally substituted with one or more substituents selected from halogen, —NO2, —CN, —OR10, —SR10, —N(R10)2, —S(?O)R10, —S(?O)2R10, —S(?O)2N(R10)2, —NR10S(?O)2R10, —C(O)R10, —C(O)OR10, —OC(O)R10, —OC(O)OR10, —OC(O)N(R10)2, —NR10C(O)R10, —C(O)N(R10)2, ?O, ?S, ?N(R10), —P(O)(OR7)2, —OP(O)(OR7)2, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, and C2-6 alkynyl;
R7 is independently selected at each occurrence from hydrogen, —C(O)R10, —C(O)OR10 and —C(O)N(R4)—; C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, and C3-12 carbocycle, each of which is independently optionally substituted at each occurrence with one or more substituents selected from halogen, —NO2, —CN, —OR10, —SR10, —S—S—R10, —N(R10)2, —S(?O)R10, —S(?O)2R10, —S(?O)2N(R10)2, —NR10S(?O)2R10, —S—C(O)R10, —C(O)R10, —C(O)OR10, —OC(O)R10, —OC(O)OR10, —OC(O)N(R10)2, —NR10C(O)R10, —C(O)N(R10)2, ?O, ?S, ?N(R10), —P(O)(OR10)2, —OP(O)(OR10)2, C3-12 carbocycle and 3- to 12-membered heterocycle; and C3-12 carbocycle and 3- to 12-membered heterocycle, wherein each C3-12 carbocycle and 3- to 12-membered heterocycle in R7 is independently optionally substituted with one or more substituents selected from halogen, —NO2, —CN, —OR10, —SR10, —N(R10)2, —S(?O)R10, —S(?O)2R10, —S(?O)2N(R10)2, —NR10S(?O)2R10, —C(O)R10, —C(O)OR10, —OC(O)R10, —OC(O)OR10, —OC(O)N(R10)2, —NR10C(O)R10, —C(O)N(R10)2, ?O, ?S, ?N(R10), —P(O)(OR10)2, —OP(O)(OR10)2, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, and C2-6 alkynyl;
R10 at each occurrence is independently selected from hydrogen; and C1-20 alkyl, C2-20 alkenyl, C2-20 alkynyl, C3-12 carbocycle and 3- to 12-membered heterocycle, each of which may be optionally substituted by halogen, —CN, —NO2, —OH and —OCH3; and
X at each occurrence is independently selected from bond, —O—, —S—, —N(R4)—, —C(O)—, —C(O)O—, —OC(O)—, —OC(O)O—, —C(O)N(R4)—, —C(O)N(R4)C(O)—, —C(O)N(R4)C(O)N(R4)—, —N(R4)C(O)—, —N(R4)C(O)N(R4)—, —N(R4)C(O)O—, —OC(O)N(R4)—, —C(NR4)—, —N(R4)C(NR4)—, —C(NR4)N(R4)—, —N(R4)C(NR4)N(R4)—, —S(O)2—, —OS(O)—, —S(O)O—, —S(O)—, —OS(O)2—, —S(O)2O—, —N(R4)S(O)2—, —S(O)2N(R4)—, —N(R4)S(O)—, —S(O)N(R4)—, —N(R4)S(O)2N(R4)—, and —N(R4)S(O)N(R4)—.

US Pat. No. 11,111,258

3,3,3?,3?-TETRAMETHYL-1,1?-SPIROBIINDANE-BASED PHOSPHINOOXAZOLINE LIGAND COMPOUND, PREPARATION METHOD AND USES OF THE SAME

ZHEJIANG UNIVERSITY, Han...


1. A 3,3,3?,3?-tetramethyl-1,1?-spirobiindane-based phosphinooxazoline ligand, being a enantiomer or a diastereoisomer of a compound represented by formula I:



wherein R1 and R6 are each independently selected from the group consisting of hydrogen, C1-C10 alkyl or perfluoroalkyl, C3-C6 cycloalkyl, and C1-C4 alkoxy or perfluoroalkoxy; R2, R3, R4, and R5 are each independently selected from the group consisting of hydrogen, halogen, C1-C10 alkyl or perfluoroalkyl, and C3-C6 cycloalkyl; R7 is selected from the group consisting of hydrogen, C1-C10 alkyl or perfluoroalkyl, C3-C6 cycloalkyl, C6-C14 aryl, CMe2OBn, CMe2Ph, CMePh2, CPh3, CH(Ph)OMe, and CH(Ph)OBn; R8 and R9 are each independently selected from the group consisting of hydrogen, C1-C10 alkyl or perfluoroalkyl, C3-C6 cycloalkyl, C6-C14 aryl, CH2OCHPh2, CH2OCPh3, and CH2OCH2Ph; and R10 is selected from the group consisting of C1-C10 alkyl or perfluoroalkyl, C3-C6 cycloalkyl, and C6-C14 aryl.

US Pat. No. 11,111,257

MOLECULAR CATALYSTS FOR SELECTIVE HYDROGENOLYSIS OF AMIDES

Eastman Chemical Company,...


1. A compound having the structural formula (I):




US Pat. No. 11,111,254

NITROGEN-CONTAINING MACROCYCLIC CONJUGATES AS RADIOPHARMACEUTICALS

The University of Melbour...


1. A compound of formula (I),



wherein:
L is a nitrogen-containing macrocyclic metal ligand of the formula




V is selected from the group consisting of N and CR4;
each Rx and Ry are independently selected from the group consisting of H, CH3, CO2H, NO2, CH2OH, H2PO4, HSO3, CN, CONH2 and CHO;
each p is independently an integer selected from the group consisting of 2, 3, and 4; R4 is selected from the group consisting of H, OH, halogen, NO2, NH2, optionally
substituted C1-C12alkyl, optionally substituted C6-C-18aryl, cyano, CO2R5, NHR5, N(R5)2 and a group of the formula:




wherein
X1 is a linking moiety;
Y1 is selected from the group consisting of OR6, SR7, N(R8)2 and a molecular recognition moiety;
wherein R5 is H or C1-C12alkyl;
R6 is selected from the group consisting of H, halogen, an oxygen protecting group, optionally substituted C1-C12alkyl, optionally substituted C2-C12alkenyl, optionally substituted C2-C12alkynyl and optionally substituted C2-C12 heteroalkyl;
R7 is selected from the group consisting of H, halogen, a sulfur protecting group, optionally substituted C1-C12alkyl, optionally substituted C2-C-12alkenyl, optionally substituted C2-C12alkynyl and optionally substituted C2-C12 heteroalkyl;
each R8 is independently selected from the group consisting of H, a nitrogen protecting group, optionally substituted C1-C12alkyl, optionally substituted C2-C12alkenyl, optionally substituted C2-C12alkynyl and optionally substituted C2-C12 heteroalkyl;
X is a linking moiety;
Y is a molecular recognition moiety, wherein the molecular recognition moiety is a molecular recognition portion of folic acid;
or a pharmaceutically acceptable salt or complex thereof.

US Pat. No. 11,111,253

6-ARYL-7-SUBSTITUTED-3-(1H-PYRAZOL-5-YL)-7H-[1,2,4]TRIAZOLO[3,4-B][1,3,4]THIADIAZINES AS INHIBITORS OF THE STAT3 PATHWAY WITH ANTI-PROLIFERATIVE ACTIVITY


1. A compound represented by the following formula:



wherein:R is selected from the group consisting of a C1-C6 alkyl or aryl, optionally substituted by one or more selected from the group consisting of —OR?, —NR?R?,





and an optionally substituted phenyl, wherein:(1) R? and R? are each independently selected from —H, C1-C6 alkyl and C1-C6 alkyl substituted by one or more fluoro groups, and when R? and R? are each alkyl they may form a ring, and
(2) Y is selected from C1-C6 alkyl, and —NR?R?, wherein when the optionally substituted phenyl contains a substituent, the substituent is selected from —OR?, —NR?R?, and






R1 is





wherein:(1) each Z is independently selected from halogen, C1-C6 alkyl, C1-C6 alkyl substituted by one or more fluoro groups, —OR?, —NR?R?,






(2) a is an integer of 0 to 4,
(3) Y? is selected from C1-C6 alkyl, C1-C6 alkyl substituted by one or more fluoro groups, —OR?, and —NR?R?,
wherein R and R1 may form a 5 or 6 membered ring that is optionally substituted by one or more selected from the group consisting of —OR?, —NR?R?,





and an optionally substituted phenyl,X is phenyl optionally substituted by one or more halogen, and
R2 is absent or phenyl optionally substituted by one or more halogen or a pharmaceutically acceptable solvate or salt thereof, and

wherein when R and R1 are both unsubstituted phenyl, then R2 cannot be unsubstituted phenyl.

US Pat. No. 11,111,252

PYRIMIDINE COMPOUNDS AND PYRIMIDO INDOLE COMPOUNDS AND METHODS OF USE

Duquesne University of Th...


1. A compound of the formula:



wherein R is 2-OCH3, 3-OCH3, 4-OCH3, or 3,4-diOCH3, or a pharmaceutically acceptable salt or hydrate thereof.

US Pat. No. 11,111,251

POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M1

Vanderbilt University, N...


1. A compound of formula (I),



or a pharmaceutically acceptable salt thereof, wherein
X is CR3a or N;
Y is CR3b or N;
Z is S, O, or NR4;
L is —[C(RaRb)]p—, C2-C6-alkenylenyl, C(O), O, or S;
A1 is Cyc1 or Cyc2-Q-Cyc3;
R1 is hydrogen, alkyl, alkoxy, alkoxyalkyl, halogen, cyano, or haloalkyl;
R2 is hydrogen, alkyl, or haloalkyl;
M is a bond, C2-C6-alkenylenyl, or —[C(RcRd)]t—[C(ReRf)]k—;
A2 is alkyl, alkoxy, hydroxyalkyl, alkoxyalkyl, haloalkyl, cyanoalkyl, cycloalkyl, heterocycle, heteroaryl, or aryl; or A2 and R2, together with the atoms to which they are attached, form a heterocycle;R3a and R3b are each independently selected from hydrogen, alkyl, cyano, alkoxy, alkoxyalkyl, haloalkyl, and halogen;
R4 is hydrogen or alkyl;
R5 is independently, at each occurrence, hydrogen, alkyl, or —C(O)Rg;
Cyc1 is aryl, heteroaryl, heterocycle, or cycloalkyl;
Cyc2 is aryl, heteroaryl, heterocycle, or cycloalkyl;
Q is a bond, C1-C6-alkylenyl, C2-C6-alkenylenyl, C(O)NH, O, S, or NR5;
Cyc3 is aryl, heteroaryl, heterocycle, or cycloalkyl;
Ra, Rb, Rc, Rd, Re, and Rf are each independently hydrogen, alkyl, hydroxyalkyl, haloalkyl, hydroxy, cyano, alkoxy, alkoxyalkyl, or halogen;
p is 0, 1, 2, 3, 4, 5, or 6;
t is 0, 1, 2, or 3;
k is 0, 1, 2, or 3; and
Rg is independently, at each occurrence, alkyl, aryl, heteroaryl, cycloalkyl, or alkoxy;


wherein said aryl, heteroaryl, cycloalkyl, and heterocycle, at each occurrence, are independently substituted or unsubstituted.

US Pat. No. 11,111,249

HETEROARYL-PYRAZOLE DERIVATIVE, AND PREPARATION METHOD THEREFOR AND MEDICAL APPLICATION THEREOF

Jiangsu Hengrui Medicine ...


1. A compound of formula (I):



or a tautomer, a mesomer, a racemate, an enantiomer, a diastereomer thereof, or a mixture thereof, or a pharmaceutically acceptable salt thereof,
wherein,
ring A is selected from the group consisting of cycloalkyl, aryl and heteroaryl;
G is N or CR4;
L1 is selected from the group consisting of —NR5—, —O—, —C(O)—, —S(O)m—, —N(R5)C(O)—, —C(O)N(R5)—, —N(R5)S(O)2—, —S(O)2N(R5)— and a covalent bond;
R1 is selected from the group consisting of hydrogen atom, alkyl, haloalkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl and heteroaryl, wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl and heteroaryl is independently and optionally substituted by one or more substituents selected from the group consisting of alkyl, alkoxy, halogen, haloalkyl, hydroxy, hydroxyalkyl, cyano, amino, nitro, cycloalkyl, heterocyclyl, aryl and heteroaryl;
each R2 is identical or different, and each is independently selected from the group consisting of hydrogen atom, halogen, alkyl, alkoxy, haloalkyl, hydroxy, hydroxyalkyl, cyano, amino, nitro, cycloalkyl, heterocyclyl, aryl, heteroaryl, —C(O)R6, —C(O)OR6, —S(O)mR6, —NR7R8 and —C(O)NR7R8, wherein each of the alkyl, cycloalkyl, heterocyclyl, aryl and heteroaryl is independently and optionally substituted by one or more substituents selected from the group consisting of alkyl, alkoxy, halogen, haloalkyl, hydroxy, hydroxyalkyl, cyano, amino, nitro, cycloalkyl, heterocyclyl, aryl and heteroaryl;
L2 is alkylene or a covalent bond, wherein the alkylene is optionally substituted by one or more substituents selected from the group consisting of halogen, alkyl, alkoxy, haloalkyl, hydroxy, hydroxyalkyl, cyano, amino, nitro, cycloalkyl and heterocyclyl;
R3 is selected from the group consisting of hydrogen atom, alkyl, alkoxy, halogen, haloalkyl, hydroxy, hydroxyalkyl, cyano, amino, nitro, cycloalkyl, heterocyclyl, aryl, heteroaryl, —C(O)R6, —C(O)OR6, —S(O)mR6, —NR7R8 and —C(O)NR7R8, wherein each of the cycloalkyl, heterocyclyl, aryl and heteroaryl is independently and optionally substituted by one or more substituents selected from the group consisting of alkyl, alkoxy, halogen, haloalkyl, hydroxy, hydroxyalkyl, cyano, amino, nitro, cycloalkyl, heterocyclyl, aryl, heteroaryl, —C(O)R6, —C(O)OR6, —S(O)mR6, —NR7R8 and —C(O)NR7R8;
Ra and Rb are identical or different, and each is independently selected from the group consisting of hydrogen atom, halogen, alkyl, alkoxy, haloalkyl, hydroxy, hydroxyalkyl, cyano, amino, nitro, cycloalkyl, heterocyclyl, aryl and heteroaryl;
R4 is selected from the group consisting of hydrogen atom, halogen, alkyl, alkoxy, haloalkyl, hydroxy, hydroxyalkyl, cyano, amino, nitro, cycloalkyl, heterocyclyl, aryl and heteroaryl;
R5 is selected from the group consisting of hydrogen atom, alkyl, haloalkyl, cycloalkyl, heterocyclyl, aryl and heteroaryl;
R6 is selected from the group consisting of hydrogen atom, alkyl, haloalkyl, amino, hydroxy, hydroxyalkyl, cycloalkyl, heterocyclyl, aryl and heteroaryl;
R7 and R8 are identical or different, and each is independently selected from the group consisting of hydrogen atom, alkyl, haloalkyl, cycloalkyl, heterocyclyl, aryl and heteroaryl, wherein each of the alkyl, cycloalkyl, heterocyclyl, aryl and heteroaryl is independently and optionally substituted by one or more substituents selected from the group consisting of alkyl, alkoxy, halogen, amino, cyano, nitro, hydroxy, hydroxyalkyl, cycloalkyl, heterocyclyl, aryl and heteroaryl;
or, R7 and R8 are linked together with the attached nitrogen atom to form heterocyclyl, wherein, except the one nitrogen atom, the heterocyclyl contains one or two identical or different heteroatoms selected from the group consisting of N, O and S, and the heterocyclyl is optionally substituted by one or more substituents selected from the group consisting of alkyl, alkoxy, halogen, amino, cyano, nitro, hydroxy, hydroxyalkyl, cycloalkyl, heterocyclyl, aryl and heteroaryl;
n is 0, 1, 2, 3 or 4; and
m is 0, 1 or 2.

US Pat. No. 11,111,248

CRYSTAL FORM OF 2-(6-METHYL-PYRIDIN-2-YL)-3-YL-[6-AMIDO-QUINOLIN-4-YL]-5,6-DIHYDRO-4H-PYRROLO[1,2-B]PYRAZOLE, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL COMPOSITION THEREOF

Hangzhou SoliPharma Co., ...


1. Crystalline Form 1 of galunisertib of formula (I):




wherein the crystalline Form 1 is characterized by a powder X-ray diffraction pattern comprising diffraction peaks at angles (° 2?) of 10.2°±0.2°, 14.6°±0.2°, 15.8°±0.2°, 19.0°±0.2°, 19.4°±0.2°, and 21.9°±0.2°.

US Pat. No. 11,111,247

PYRAZOLOPYRIMIDINE COMPOUNDS AND USES THEREOF

Incyte Corporation, Wilm...


1. A compound of Formula I:



or a pharmaceutically acceptable salt thereof, wherein:
R1 is selected from Cy1, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, halo, CN, NO2, ORa, SRa, C(O)Rb, C(O)NRcRd, C(O)ORa, OC(O)Rb, OC(O)NRcRd, NRcRd, NRcC(O)Rb, NRcC(O)ORa, NRcC(O)NRcRd, C(?NRe)Rb, C(?NORa)Rb, C(?NRe)NRcRd, NRcC(?NRe)NRcRd, NRcS(O)Rb, NRcS(O)2Rb, NRcS(O)2NRcRd, S(O)Rb, S(O)NRcRd, S(O)2Rb, and S(O)2NRcRd; wherein said C2-6 alkenyl and C2-6 alkynyl are each substituted with 1, 2, 3, or 4 substituents independently selected from R10;
Cy1 is selected from C3-8 cycloalkyl, 4-12 membered heterocycloalkyl, C6-10 aryl and 5-10 membered heteroaryl; wherein the 4-12 membered heterocycloalkyl and 5-10 membered heteroaryl each has at least one ring-forming carbon atom and 1, 2, 3, or 4 ring-forming heteroatoms independently selected from N, O, and S; wherein the N and S are optionally oxidized; wherein a ring-forming carbon atom of 5-10 membered heteroaryl and 4-12 membered heterocycloalkyl is optionally substituted by oxo to form a carbonyl group; and wherein the C3-8 cycloalkyl, 4-12 membered heterocycloalkyl, C6-10 aryl and 5-10 membered heteroaryl are each optionally substituted with 1, 2, 3 or 4 substituents independently selected from R10;
Cy is 4-12 membered heterocycloalkyl; wherein the 4-12 membered heterocycloalkyl has at least one ring-forming carbon atom and 1, 2, 3, or 4 ring-forming heteroatoms independently selected from N, O, and S; wherein the N and S are optionally oxidized; wherein a ring-forming carbon atom of 4-12 membered heterocycloalkyl is optionally substituted by oxo to form a carbonyl group; wherein when the 4-12 membered heterocycloalkyl of Cy has a fused aromatic ring, the 4-12 membered heterocycloalkyl is directly attached to the pyrazolopyrimidine core structure through a ring-forming atom of the saturated or partially saturated ring; and wherein the 4-12 membered heterocycloalkyl is optionally substituted with 1, 2, 3, 4 or 5 substituents independently selected from R20;
R2 is selected from H, D, C1-4 alkyl, C1-4 haloalkyl, C1-4 alkoxy and C1-4 haloalkoxy;
each R10 is independently selected from C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-10 cycloalkyl, 4-10 membered heterocycloalkyl, C6-10 aryl, 5-10 membered heteroaryl, C3-10 cycloalkyl-C1-3 alkylene, 4-10 membered heterocycloalkyl-C1-3 alkylene, C6-10 aryl-C1-3 alkylene, 5-10 membered heteroaryl-C1-3 alkylene, halo, D, CN, NO2, ORa1, SRa1, C(O)Rb1, C(O)NRc1Rd1, C(O)ORa1, OC(O)Rb1, OC(O)NRc1Rd1, NRc1Rd1, NRc1C(O)Rb1, NRc1C(O)ORa1 NRc1C(O)NRc1Rd1, C(?NRe1)Rb1, C(?NORa1)Rb1, C(?NRe1)NRc1Rd1, NRc1C(?NRe1)NRc1Rd1, NRc1S(O)Rb1, NRc1S(O)2Rb1, NRc1S(O)2NRc1Rd1, S(O)Rb1, S(O)NRc1Rd1, S(O)2Rb1, and S(O)2NRc1Rd1; wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 cycloalkyl, 4-10 membered heterocycloalkyl, C6-10 aryl, 5-10 membered heteroaryl, C3-10 cycloalkyl-C1-3 alkylene, 4-10 membered heterocycloalkyl-C1-3 alkylene, C6-10 aryl-C1-3 alkylene and 5-10 membered heteroaryl-C1-3 alkylene are each optionally substituted with 1, 2, 3, or 4 substituents independently selected from R11;
or two R10 substituents taken together with the carbon atom to which they are attached form a spiro 4-7-membered heterocycloalkyl ring, or a spiro C3-6 cycloalkyl ring; wherein each spiro 4-7-membered heterocycloalkyl ring has at least one ring-forming carbon atom and 1, 2 or 3, ring-forming heteroatoms independently selected from N, O, and S; wherein a ring-forming carbon atom of each spiro 4-7-membered heterocycloalkyl ring is optionally substituted by oxo to form a carbonyl group; and wherein the spiro 4-7-membered heterocycloalkyl ring and spiro C3-6 cycloalkyl ring are each optionally substituted with 1, 2, 3 or 4 substituents independently selected from R11;
each R11 is independently selected from C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-10 cycloalkyl, 4-10 membered heterocycloalkyl, C6-10 aryl, 5-10 membered heteroaryl, C3-10 cycloalkyl-C1-3 alkylene, 4-10 membered heterocycloalkyl-C1-3 alkylene, C6-10 aryl-C1-3 alkylene, 5-10 membered heteroaryl-C1-3 alkylene, halo, D, CN, ORa3, SRa3, C(O)Rb3, C(O)NRc3Rd3, C(O)ORa3, NRc3Rd3 NRc3C(O)Rb3, NRc3C(O)ORa3, NRc3S(O)Rb3, NRc3S(O)2Rb3, NRc3S(O)2NRc3Rd3 S(O)Rb3, S(O)NRc3Rd3, S(O)2Rb3, and S(O)2NRc3Rd3; wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 cycloalkyl, 4-10 membered heterocycloalkyl, C6-10 aryl, 5-10 membered heteroaryl, C3-10 cycloalkyl-C1-3 alkylene, 4-10 membered heterocycloalkyl-C1-3 alkylene, C6-10 aryl-C1-3 alkylene and 5-10 membered heteroaryl-C1-3 alkylene are each optionally substituted with 1, 2, 3, or 4 substituents independently selected from R12;
each R12 is independently selected from C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-6 cycloalkyl, C6-10 aryl, 5-10 membered heteroaryl, 4-7 membered heterocycloalkyl, C3-6 cycloalkyl-C1-3 alkylene, 4-7 membered heterocycloalkyl-C1-3 alkylene, C6-10 aryl-C1-3 alkylene, 5-10 membered heteroaryl-C1-3 alkylene, halo, D, CN, ORa5, SRa5, C(O)Rb5, C(O)NRc5Rd5, C(O)ORa5, NRc5Rd5, NRc5C(O)Rb5, NRc5C(O)ORa5, NRc5S(O)Rb5, NRc5S(O)2Rb5, NRc5S(O)2NRc5Rd5 S(O)Rb5, S(O)NRc5Rd5, S(O)2Rb5, and S(O)2NRc5Rd5; wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-6 cycloalkyl, C6-10 aryl, 5-10 membered heteroaryl, 4-7 membered heterocycloalkyl, C3-6 cycloalkyl-C1-3 alkylene, 4-7 membered heterocycloalkyl-C1-3 alkylene, C6-10 aryl-C1-3 alkylene, and 5-10 membered heteroaryl-C1-3 alkylene are each optionally substituted with 1, 2, 3, or 4 substituents independently selected from Rg;
each R20 is independently selected from C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-10 cycloalkyl, 4-10 membered heterocycloalkyl, C6-10 aryl, 5-10 membered heteroaryl, C3-10 cycloalkyl-C1-3 alkylene, 4-10 membered heterocycloalkyl-C1-3 alkylene, C6-10 aryl-C1-3 alkylene, 5-10 membered heteroaryl-C1-3 alkylene, halo, D, CN, NO2, ORa2, SRa2, C(O)Rb2, C(O)NRc2Rd2, C(O)ORa2, OC(O)Rb2, OC(O)NRc2Rd2, NRc2Rd2, NRc2C(O)Rb2, NRc2C(O)ORa2, NRc2C(O)NRc2Rd2, C(?NRe2)Rb2, C(?NORa2)Rb2, C(?NRe2)NRc2Rd2, NRc2C(?NRe2)NRc2Rd2, NRc2S(O)Rb2, NRc2S(O)2Rb2, NRc2S(O)2NRc2Rd2, S(O)Rb2 S(O)NRc2Rd2, S(O)2Rb2, and S(O)2NRc2Rd2; wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 cycloalkyl, 4-10 membered heterocycloalkyl, C6-10 aryl, 5-10 membered heteroaryl, C3-10 cycloalkyl-C1-3 alkylene, 4-10 membered heterocycloalkyl-C1-3 alkylene, C6-10 aryl-C1-3 alkylene and 5-10 membered heteroaryl-C1-3 alkylene are each optionally substituted with 1, 2, 3, or 4 substituents independently selected from R21;
each R21 is independently selected from C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-10 cycloalkyl, 4-10 membered heterocycloalkyl, C6-10 aryl, 5-10 membered heteroaryl, C3-10 cycloalkyl-C1-3 alkylene, 4-10 membered heterocycloalkyl-C1-3 alkylene, C6-10 aryl-C1-3 alkylene, 5-10 membered heteroaryl-C1-3 alkylene, halo, D, CN, ORa4, SRa4, C(O)Rb4, C(O)NRc4Rd4, C(O)ORa4, NRc4Rd4, NRc4C(O)Rb4, NRc4C(O)ORa4, NRc4S(O)Rb4, NRc4S(O)2Rb4, NRc4S(O)2NRc4Rd4 S(O)Rb4, S(O)NRc4Rd4, S(O)2Rb4, and S(O)2NRc4Rd4; wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 cycloalkyl, 4-10 membered heterocycloalkyl, C6-10 aryl, 5-10 membered heteroaryl, C3-10 cycloalkyl-C1-3 alkylene, 4-10 membered heterocycloalkyl-C1-3 alkylene, C6-10 aryl-C1-3 alkylene and 5-10 membered heteroaryl-C1-3 alkylene are each optionally substituted with 1, 2, 3, or 4 substituents independently selected from R22;
each R22 is independently selected from C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-6 cycloalkyl, phenyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, C3-6 cycloalkyl-C1-3 alkylene, 4-7 membered heterocycloalkyl-C1-3 alkylene, phenyl-C1-3 alkylene, 5-6 membered heteroaryl-C1-3 alkylene, halo, D, CN, ORa6, SRa6, C(O)Rb6, C(O)NRc6Rd6, C(O)ORa6, NRc6Rd6 NRc6C(O)Rb6, NR6C(O)ORa6 NRc6S(O)Rb6, NRc6S(O)2Rb6, NRc6S(O)2NRc6Rd6 S(O)Rb6, S(O)NRc6Rd6, S(O)2Rb6, and S(O)2NRc6Rd6; wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-6 cycloalkyl, phenyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, C3-6 cycloalkyl-C1-3 alkylene, 4-7 membered heterocycloalkyl-C1-3 alkylene, phenyl-C1-3 alkylene, and 5-6 membered heteroaryl-C1-3 alkylene are each optionally substituted with 1, 2, 3, or 4 substituents independently selected from Rg;
each Ra, Rc, and Rd is independently selected from H, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-10 cycloalkyl, 4-10 membered heterocycloalkyl, C6-10 aryl, 5-10 membered heteroaryl, C3-10 cycloalkyl-C1-3 alkylene, 4-10 membered heterocycloalkyl-C1-3 alkylene, C6-10 aryl-C1-3 alkylene, and 5-10 membered heteroaryl-C1-3 alkylene; wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 cycloalkyl, 4-10 membered heterocycloalkyl, C6-10 aryl, 5-10 membered heteroaryl, C3-10 cycloalkyl-C1-3 alkylene, 4-10 membered heterocycloalkyl-C1-3 alkylene, C6-10 aryl-C1-3 alkylene, and 5-10 membered heteroaryl-C1-3 alkylene are each optionally substituted with 1, 2, 3, or 4 substituents independently selected from R10;
or any Rc and Rd attached to the same N atom, together with the N atom to which they are attached, form a 4-10 membered heterocycloalkyl group optionally substituted with 1, 2, 3 or 4 substituents independently selected from R10;
each Rb is independently selected from C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-10 cycloalkyl, 4-10 membered heterocycloalkyl, C6-10 aryl, 5-10 membered heteroaryl, C3-10 cycloalkyl-C1-3 alkylene, 4-10 membered heterocycloalkyl-C1-3 alkylene, C6-10 aryl-C1-3 alkylene, and 5-10 membered heteroaryl-C1-3 alkylene; wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 cycloalkyl, 4-10 membered heterocycloalkyl, C6-10 aryl, 5-10 membered heteroaryl, C3-10 cycloalkyl-C1-3 alkylene, 4-10 membered heterocycloalkyl-C1-3 alkylene, C6-10 aryl-C1-3 alkylene, and 5-10 membered heteroaryl-C1-3 alkylene are each optionally substituted with 1, 2, 3, or 4 substituents independently selected from R10;
each Re is independently selected from H, CN, C1-6 alkyl, C1-6 haloalkyl, C1-6 alkylthio, C1-6 alkylsulfonyl, C1-6 alkylcarbonyl, carbamyl, C1-6 alkylcarbamyl, di(C1-6 alkyl)carbamyl, aminosulfonyl, C1-6 alkylaminosulfonyl and di(C1-6 alkyl)aminosulfonyl;
each Ra1, Rc1 and Rd1 is independently selected from H, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-10 cycloalkyl, 4-10 membered heterocycloalkyl, C6-10 aryl, 5-10 membered heteroaryl, C3-10 cycloalkyl-C1-3 alkylene, 4-10 membered heterocycloalkyl-C1-3 alkylene, C6-10 aryl-C1-3 alkylene, and 5-10 membered heteroaryl-C1-3 alkylene; wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 cycloalkyl, 4-10 membered heterocycloalkyl, C6-10 aryl, 5-10 membered heteroaryl, C3-10 cycloalkyl-C1-3 alkylene, 4-10 membered heterocycloalkyl-C1-3 alkylene, C6-10 aryl-C1-3 alkylene, and 5-10 membered heteroaryl-C1-3 alkylene are each optionally substituted with 1, 2, 3, or 4 substituents independently selected from R11;
or any Rc1 and Rd1 attached to the same N atom, together with the N atom to which they are attached, form a 4-10 membered heterocycloalkyl group optionally substituted with 1, 2, 3 or 4 substituents independently selected from R11;
each Rb1 is independently selected from C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-10 cycloalkyl, 4-10 membered heterocycloalkyl, C6-10 aryl, 5-10 membered heteroaryl, C3-10 cycloalkyl-C1-3 alkylene, 4-10 membered heterocycloalkyl-C1-3 alkylene, C6-10 aryl-C1-3 alkylene, and 5-10 membered heteroaryl-C1-3 alkylene; wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 cycloalkyl, 4-10 membered heterocycloalkyl, C6-10 aryl, 5-10 membered heteroaryl, C3-10 cycloalkyl-C1-3 alkylene, 4-10 membered heterocycloalkyl-C1-3 alkylene, C6-10 aryl-C1-3 alkylene, and 5-10 membered heteroaryl-C1-3 alkylene are each optionally substituted with 1, 2, 3, or 4 substituents independently selected from R11;
each Re1 is independently selected from H, CN, C1-6 alkyl, C1-6 haloalkyl, C1-6 alkylthio, C1-6 alkylsulfonyl, C1-6 alkylcarbonyl, C1-6 alkylaminosulfonyl, carbamyl, C1-6 alkylcarbamyl, di(C1-6 alkyl)carbamyl, aminosulfonyl, and di(C1-6 alkyl)aminosulfonyl;
each Ra2, Rc2 and Rd2 is independently selected from H, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-10 cycloalkyl, 4-10 membered heterocycloalkyl, C6-10 aryl, 5-10 membered heteroaryl, C3-10 cycloalkyl-C1-3 alkylene, 4-10 membered heterocycloalkyl-C1-3 alkylene, C6-10 aryl-C1-3 alkylene, and 5-10 membered heteroaryl-C1-3 alkylene; wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 cycloalkyl, 4-10 membered heterocycloalkyl, C6-10 aryl, 5-10 membered heteroaryl, C3-10 cycloalkyl-C1-3 alkylene, 4-10 membered heterocycloalkyl-C1-3 alkylene, C6-10 aryl-C1-3 alkylene, and 5-10 membered heteroaryl-C1-3 alkylene are each optionally substituted with 1, 2, 3, or 4 substituents independently selected from R21;
or any Rc2 and Rd2 attached to the same N atom, together with the N atom to which they are attached, form a 4-10 membered heterocycloalkyl group optionally substituted with 1, 2, 3 or 4 substituents independently selected from R21;
each Rb2 is independently selected from C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-10 cycloalkyl, 4-10 membered heterocycloalkyl, C6-10 aryl, 5-10 membered heteroaryl, C3-10 cycloalkyl-C1-3 alkylene, 4-10 membered heterocycloalkyl-C1-3 alkylene, C6-10 aryl-C1-3 alkylene, and 5-10 membered heteroaryl-C1-3 alkylene; wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 cycloalkyl, 4-10 membered heterocycloalkyl, C6-10 aryl, 5-10 membered heteroaryl, C3-10 cycloalkyl-C1-3 alkylene, 4-10 membered heterocycloalkyl-C1-3 alkylene, C6-10 aryl-C1-3 alkylene, and 5-10 membered heteroaryl-C1-3 alkylene are each optionally substituted with 1, 2, 3, or 4 substituents independently selected from R21;
each Re2 is independently selected from H, CN, C1-6 alkyl, C1-6 haloalkyl, C1-6 alkylthio, C1-6 alkylsulfonyl, C1-6 alkylcarbonyl, C1-6 alkylaminosulfonyl, carbamyl, C1-6 alkylcarbamyl, di(C1-6 alkyl)carbamyl, aminosulfonyl, and di(C1-6 alkyl)aminosulfonyl;
each Ra3, Rc3 and Rd3 is independently selected from H, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-6 cycloalkyl, phenyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, C3-6 cycloalkyl-C1-3 alkylene, 4-7 membered heterocycloalkyl-C1-3 alkylene, phenyl-C1-3 alkylene, and 5-6 membered heteroaryl-C1-3 alkylene; wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-6 cycloalkyl, phenyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, C3-6 cycloalkyl-C1-3 alkylene, 4-7 membered heterocycloalkyl-C1-3 alkylene, phenyl-C1-3 alkylene, and 5-6 membered heteroaryl-C13 alkylene are each optionally substituted with 1, 2, 3, or 4 substituents independently selected from R12;
or any Rc3 and Rd3 attached to the same N atom, together with the N atom to which they are attached, form a 4-, 5-, 6- or 7-membered heterocycloalkyl group optionally substituted with 1, 2 or 3 substituents independently selected from R12;
each Rb3 is independently selected from C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-6 cycloalkyl, phenyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, C3-6 cycloalkyl-C1-3 alkylene, 4-7 membered heterocycloalkyl-C1-3 alkylene, phenyl-C1-3 alkylene, and 5-6 membered heteroaryl-C1-3 alkylene; wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-6 cycloalkyl, phenyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, C3-6 cycloalkyl-C1-3 alkylene, 4-7 membered heterocycloalkyl-C1-3 alkylene, phenyl-C1-3 alkylene, and 5-6 membered heteroaryl-C1-3 alkylene are each optionally substituted with 1, 2, 3, or 4 substituents independently selected from R12;
each Ra4, Rc4 and Rd4 is independently selected from H, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-6 cycloalkyl, phenyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, C3-6 cycloalkyl-C1-3 alkylene, 4-7 membered heterocycloalkyl-C1-3 alkylene, phenyl-C1-3 alkylene, and 5-6 membered heteroaryl-C1-3 alkylene; wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-6 cycloalkyl, phenyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, C3-6 cycloalkyl-C1-3 alkylene, 4-7 membered heterocycloalkyl-C1-3 alkylene, phenyl-C1-3 alkylene, and 5-6 membered heteroaryl-C1-3 alkylene are each optionally substituted with 1, 2, 3, or 4 substituents independently selected from R22;
or any Rc4 and Rd4 attached to the same N atom, together with the N atom to which they are attached, form a 4-, 5-, 6- or 7-membered heterocycloalkyl group optionally substituted with 1, 2 or 3 substituents independently selected from R22;
each Rb4 is independently selected from C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-6 cycloalkyl, phenyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, C3-6 cycloalkyl-C1-3 alkylene, 4-7 membered heterocycloalkyl-C1-3 alkylene, phenyl-C1-3 alkylene, and 5-6 membered heteroaryl-C1-3 alkylene; wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-6 cycloalkyl, phenyl, 5-6 membered heteroaryl, 4-7 membered heterocycloalkyl, C3-6 cycloalkyl-C1-3 alkylene, 4-7 membered heterocycloalkyl-C1-3 alkylene, phenyl-C1-3 alkylene, and 5-6 membered heteroaryl-C1-3 alkylene are each optionally substituted with 1, 2, 3, or 4 substituents independently selected from R22;
each Ra5, Rc5 and Rd5 is independently selected from H, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl and C1-6 haloalkyl; wherein said C1-6 alkyl, C2-6 alkenyl and C2-6 alkynyl are each optionally substituted with 1, 2, 3, or 4 substituents independently selected from Rg;
or any Rc5 and Rd5 attached to the same N atom, together with the N atom to which they are attached, form a 4-, 5-, 6- or 7-membered heterocycloalkyl group optionally substituted with 1, 2 or 3 substituents independently selected from Rg;
each Rb5 is independently selected from C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl and C1-6 haloalkyl; wherein said C1-6 alkyl, C2-6 alkenyl and C2-6 alkynyl are each optionally substituted with 1, 2, 3, or 4 substituents independently selected from Rg;
each Ra6, Rc6 and Rd6 is independently selected from H, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl and C1-6 haloalkyl; wherein said C1-6 alkyl, C2-6 alkenyl and C2-6 alkynyl are each optionally substituted with 1, 2, 3, or 4 substituents independently selected from Rg;
or any Rc6 and Rd6 attached to the same N atom, together with the N atom to which they are attached, form a 4-, 5-, 6- or 7-membered heterocycloalkyl group optionally substituted with 1, 2 or 3 substituents independently selected from Rg;
each Rb6 is independently selected from C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, and C1-6 haloalkyl; wherein said C1-6 alkyl, C2-6 alkenyl and C2-6 alkynyl are each optionally substituted with 1, 2, 3, or 4 substituents independently selected from Rg; and
each Rg is independently selected from OH, NO2, CN, halo, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C3-6 cycloalkyl, C3-6 cycloalkyl-C1-2 alkylene, C1-6 alkoxy, C1-6 haloalkoxy, C1-3 alkoxy-C1-3 alkyl, C1-3 alkoxy-C1-3 alkoxy, HO—C1-3 alkoxy, HO—C1-3 alkyl, cyano-C1-3 alkyl, H2N—C1-3 alkyl, amino, C1-6 alkylamino, di(C1-6 alkyl)amino, thio, C1-6 alkylthio, C1-6 alkylsulfinyl, C1-6 alkylsulfonyl, carbamyl, C1-6 alkylcarbamyl, di(C1-6 alkyl)carbamyl, carboxy, C1-6 alkylcarbonyl, C1-6 alkoxycarbonyl, C1-6 alkylcarbonylamino, C1-6 alkylsulfonylamino, aminosulfonyl, C1-6 alkylaminosulfonyl, di(C1-6 alkyl)aminosulfonyl, aminosulfonylamino, C1-6 alkylaminosulfonylamino, di(C1-6 alkyl)aminosulfonylamino, aminocarbonylamino, C1-6 alkylaminocarbonylamino, and di(C1-6 alkyl)aminocarbonylamino.

US Pat. No. 11,111,246

PHARMACEUTICAL SALTS OF SUBSTITUTED-QUINOXALINE-TYPE BRIDGED-PIPERIDINE COMPOUNDS

Purdue Pharma L.P., Stam...


1. A pharmaceutically acceptable salt of a compound selected from the group consisting of



wherein the pharmaceutically acceptable salt is selected from the group consisting of a p-toluenesulfonic acid salt, a sulfuric acid salt, a phosphoric acid salt, and a hydrochloric acid salt.

US Pat. No. 11,111,245

DERIVATIVES OF N-CYCLOALKYL/HETEROCYCLOALKYL-4-(IMIDAZO[1,2-A]PYRIDINE)PYRIMIDIN-2-AMINE AS THERAPEUTIC AGENTS

Aucentra Therapeutics Pty...


1. A compound of Formula I:



or a pharmaceutically acceptable salt, wherein:
A is a cycloalkyl or heterocycloalkyl, optionally substituted by one or more R6 groups such that m is an integer from 0 to 5 inclusive, and wherein said heterocycloalkyl has 1-2 heteroatoms selected from N, O and S; and
wherein R and R6 are each independently selected from the group consisting of H, alkyl, alkyl-R7, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, CH2-heteroaryl, aralkyl, halogen, NO2, CN, CF3, OH, O-alkyl, O-alkyl-R7, O-cycloalkyl, O-heterocycloalkyl, O-aryl, O-heteroaryl, NH2, NH-alkyl, NH-alkyl-R7, NH-cycloalkyl, NH-heterocycloalkyl, NH-aryl, NH-heteroaryl, NH—R7, NHO-aryl, NHCH2-aryl, N-(alkyl)2, N-(cycloalkyl)2, N-(heterocycloalkyl)2, N-(aryl)2, N-(heteroaryl)2, N-(alkyl)(R7), N-(cycloalkyl)(R7), N-(heterocycloalkyl)(R7), N-(aryl)(R7), N-(heteroaryl)(R7), COOH, CONH2, CONH-alkyl, CONH-aryl, CON-(alkyl)(R7), CON(aryl)(R7), CON(heteroaryl)(R7), CONH—R7, SO3H, SO2-alkyl, SO2-alkyl-R7, SO2-aryl, SO2-aryl-R7, SO2NH2, SO2NH-R7, CO-alkyl, CO-alkyl-R7, CO-aryl, CO-aryl-R7, CO—R7, and COOR7;
R1, R2, R3, and R4 are each independently selected from the group consisting of H, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, CH2-heteroaryl, aralkyl, O-cycloalkyl, O-heterocycloalkyl, O-aryl, O-heteroaryl, NH-cycloalkyl, NH-heterocycloalkyl, NH-aryl, NH-heteroaryl, NHO-aryl, NHCH2-aryl, N-(cycloalkyl)2, N-(heterocycloalkyl)2, N-(aryl)2, N-(heteroaryl)2, N-(cycloalkyl)(R7), N-(heterocycloalkyl)(R7), N-(aryl)(R7), N-(heteroaryl)(R7), S-(heteroaryl)(R7), CONH-aryl, CON(aryl)(R7), CON(heteroaryl)(R7), SO2-aryl, SO2-aryl-R7, CO-aryl, and CO-aryl-R7, with the proviso that at least one of R1, R2, R3 and R4 is not H; and
wherein R7 is selected from the group consisting of H, alkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, aralkyl, halogen, NO2, CN, CF3, OH, O-alkyl, O-cycloalkyl, O-heterocycloalkyl, O-aryl, O-heteroaryl, NH2, NH-alkyl, NH-cycloalkyl, NH-heterocycloalkyl, NH-aryl, NH-heteroaryl, NH—R10, N-(alkyl)2, N-(cycloalkyl)2, N-(heterocycloalkyl)2, N-(aryl)2, N-(heteroaryl)2, COOH, COO-alkyl, CONH2, CONH-alkyl, CONH-aryl, SO3H, SO2-alkyl, SO2-aryl, SO2NH2, CO-alkyl, CO-aryl;
R5 is selected from alkyl, O-alkyl, CN, and halogen; and
wherein said heterocycloalkyl and heteroaryl groups comprise 1-2 heteroatoms selected from N, S and O, and wherein said alkyl, cycloalkyl, heterocycloalkyl, aralkyl, aryl and heteroaryl groups may be optionally substituted with one or more groups selected from halogen, alkyl, CN, OH, O-methyl, O-ethyl, O-CF3, NH2, COOH, CONH2, heterocycloalkyl, CO-heterocycloalkyl, CF3, and SO2N(CH3)2.

US Pat. No. 11,111,244

ORGANIC COMPOUND AND ORGANIC ELECTROLUMINESCENCE DEVICE USING THE SAME

LUMINESCENCE TECHNOLOGY C...


1. An organic compound represented by one of the following formula (4) to formula (9) and formula (11) to formula (21):









wherein X is a divalent bridge selected from the group consisting of O, S, NR4, CR5R6, and SiR7R8; R1 to R3 are independently absent, a hydrogen atom, a halogen, a substituted or unsubstituted aryl group having 5 to 30 ring atoms, a substituted or unsubstituted heteroaryl group having 5 to 30 ring atoms, a substituted or unsubstituted arylamine group having 5 to 30 ring atoms, or a substituted or unsubstituted heteroarylamine group having 5 to 30 ring atoms; R4 is a hydrogen atom, a halogen, a substituted or unsubstituted aryl group having 5 to 30 ring atoms, a substituted or unsubstituted heteroaryl group having 5 to 30 ring atoms, a substituted or unsubstituted arylamine group having 5 to 30 ring atoms, or a substituted or unsubstituted heteroarylamine group having 5 to 30 ring atoms; and R5 to R8 are independently a hydrogen atom, a halogen, a substituted or unsubstituted alkyl group having 1 to 30 carbon atoms, a substituted or unsubstituted aryl group having 6 to 30 carbon atoms, a substituted or unsubstituted aralkyl group having 6 to 30 carbon atoms, or a substituted or unsubstituted heteroaryl group having 3 to 30 carbon atoms.

US Pat. No. 11,111,243

AZAINDOLE COMPOUNDS AS HISTONE METHYLTRANSFERASE INHIBITORS

Global Blood Therapeutics...


1. A compound of Formula (I):



wherein:
X is CR1;
Y is CR2;
Q is N and P, T, and U are independently CH or C (when R4 or R5 is attached);
Z is NR6, wherein R6 is hydrogen, alkyl, or cycloalkyl;
one of R1 and R2 is hydrogen and the other is selected from the group consisting of alkyl, alkoxy, halo, haloalkyl, haloalkoxy, and cycloalkyl;
R3 is —W-alkylene-R7, wherein:—W-alkylene- is —O—(CH2)1-3* or —O—(CH2)2—O—(CH2)2—*, wherein * indicates the point of attachment to R7;
R7 is —NRaNRb, wherein Ra and Rb are alkyl; or Ra and Rb together with the nitrogen to which they are attached form pyrrolidinyl, wherein said pyrrolidinyl is optionally substituted with one or two substituents independently selected from alkyl, halo, haloalkyl, hydroxy, alkoxy, and haloalkoxy;

R4 and R5 are independently alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, halo, hydroxy, haloalkoxy, alkoxy, cyano, NH2, NRcRd, alkoxyalkylamino, hydroxyalkylamino, aminoalkylamino, hydroxyalkyl, alkoxyalkyl, alkylthio, alkoxyalkyloxy, or phenyl, wherein the phenyl or the cycloalkyl, either alone or as part of another group are optionally substituted with one, two, or three substituents independently selected from alkyl, halo, haloalkyl, haloalkoxy, hydroxy, hydroxyalkyl, alkoxy, NH2, alkylamino, dialkylamino, carboxy, carboxyalkyl, and alkoxycarbonyl, and wherein the alkyl of R4 and R5 is optionally substituted with cycloalkyl, and the alkenyl and the alkynyl of R4 and R5 are independently optionally substituted with hydroxy or cycloalkyl;
Rc is hydrogen, alkyl, or cycloalkyl;
Rd is alkyl or cycloalkyl; and
v and w are independently 0 or 1;

or a pharmaceutically acceptable salt thereof.

US Pat. No. 11,111,242

PYRROLO[2,3-D]PYRIMIDINYL, PYRROLO[2,3-B]PYRAZINYL AND PYRROLO[2,3-D]PYRIDINYL ACRYLAMIDES

Pfizer Inc., New York, N...


1. A method for treating a disorder or condition selected from the group consisting of rheumatoid arthritis, inflammatory bowel disease, Crohn's disease, and ulcerative colitis, comprising the step of administering to a subject an effective amount of a compound having the structure:



or a pharmaceutically acceptable salt or solvate thereof, or an enantiomer or diastereomer thereof, and whereinRa, Rb, R, and Rd are independently selected from hydrogen, C1-C6 linear or branched chain alkyl, C1-6 linear or branched chain perfluoroalkyl, aryl, alkylaryl, (aryl)C1-C6 linear or branched chain alkyl, (heteroaryl)C1-C6 linear or branched chain alkyl, heteroaryl, halogen, cyano, hydroxyl, C1-C6 linear or branched chain alkoxy, amino, carboxy, aminocarbonyl, (heterocyclic)C1-C6 linear or branched chain alkyl, (C1-C6 linear or branched chain alkyl)aryl, (C1-C6 linear or branched chain alkyl)heteroaryl, and (C1-C6 linear or branched chain alkyl)heterocyclic, where said alkyl is further optionally substituted with one or more substituents selected from the group consisting of halo, hydroxy, methoxy, amino, alkylamino, dialkylamino, CF3, and C1-C6 cycloalkyl;
R0, R1, R4, and R6 are independently selected from hydrogen, C1-6 linear or branched chain alkyl, C1-C6 linear or branched chain perfluoroalkyl, C1-C6 aryl, monocyclic or bicyclic heteroaryl, comprising 5- and/or 6-membered rings, (aryl)C1-C6 linear or branched chain alkyl, (heteroaryl)C1-C6 linear or branched chain alkyl, heteroaryl, halogen, cyano, hydroxyl, C1-C6 linear or branched chain alkoxy, amino, carboxy, aminocarbonyl, (heterocyclic)C1-C6 linear or branched chain alkyl, (C1-C6 linear or branched chain alkyl)aryl, (C1-C6 linear or branched chain alkyl)heteroaryl, and (C1-C6 linear or branched chain alkyl)heterocyclic, where said alkyl is further optionally substituted with one or more substituents selected from the group consisting of halo, hydroxy, methoxy, amino, alkylamino, dialkylamino, CF3, and C1-C6 cycloalkyl; where, alternatively, R0 or R1, and/or R6, respectively together with either of R4, Ra, Rb, Rc or Rd, may independently form a bond or a C1-C6 linear alkyl chain; and/or, alternatively, R4, respectively together with either of Ra, Rb, Rc or Rd, may independently form a bond or a C1-C6 linear alkyl chain; and,
R8, R9 and R10 are all hydrogen.


US Pat. No. 11,111,241

N-(PYRIDIN-2-YL)-4-(THIAZOL-5-YL)PYRIMIDIN-2-AMINE DERIVATIVES AS THERAPEUTIC COMPOUNDS

AUCENTRA THERAPEUTICS PTY...


10. A pharmaceutical composition or medicament comprising the compound of claim 1 and at least one pharmaceutically acceptable carrier, diluent or excipient.

US Pat. No. 11,111,240

SULTAM COMPOUND AND APPLICATION METHOD THEREOF

Chai Tai Tianqing Pharmac...


1. A compound represented by formula I or a pharmaceutically acceptable salt thereof,



wherein,
X is CH2 or NR5;
R1 is C3-6 cycloalkyl or 3- to 6-membered heterocycloalkyl containing 1 to 2 heteroatoms selected from the group consisting of N, O and S, which may be optionally substituted with one or more groups R6;
R2 is phenyl or 5- to 6-membered heteroaryl containing 1 to 2 heteroatoms selected from the group consisting of N, O and S, which may be optionally substituted with one or more groups R7;
R3 is phenyl, 5- to 6-membered heteroaryl containing 1 to 2 heteroatoms selected from the group consisting of N, O and S, phenyl CH2—, or 5- to 6-membered heteroaryl CH2— containing 1 to 2 heteroatoms selected from the group consisting of N, O and S, which may be optionally substituted with one or more groups R8;
R4 is halogen, amino, hydroxyl, C1-3 haloalkyl or C1-6 alkyl;
R5 is hydrogen or C1-6 alkyl;
R6 is halogen, amino, hydroxyl, cyano, C1-3 haloalkyl, C1-6 alkyl or C3-6 cycloalkyl;
R7 is halogen, amino, hydroxyl, cyano, C1-3 haloalkyl,




?C1-6 alkyl or C3-6 cycloalkyl; or R7 forms a O?N coordination linkage with N atom in R2;
R8 is halogen, amino, hydroxyl, cyano, C1-3 haloalkyl, C1-6 alkyl, C3-6 cycloalkyl, C2-6 alkenyl or C2-6 alkynyl;
R9 is H, C1-6 alkyl, C3-6 cycloalkyl, 3- to 6-membered heterocycloalkyl containing 1 to 2 heteroatoms selected from the group consisting of N, O and S, phenyl, or 5- to 6-membered heteroaryl containing 1 to 2 heteroatoms selected from the group consisting of N, O and S, which may be optionally substituted with one or more groups R10;
R10 is halogen, amino, hydroxyl, cyano, C1-3 haloalkyl, C1-6 alkyl or C3-6 cycloalkyl;
m is 0 or 1.

US Pat. No. 11,111,239

SOLID FORMS OF(Z)-4-(5-((3-BENZYL-4-OXO-2-THIOXOTHIAZOLIDIN-5-YLIDENE)METHYL)FURAN-2-YL) BENZOIC ACID

GB006, INC., San Diego, ...


1. A method for treating a cancer comprising administering to a patient having cancer:(a) an immune checkpoint inhibitor; and
(b) a choline or meglumine salt of a compound according to Formula (I)





or a crystalline form thereof.

US Pat. No. 11,111,238

COUMARIN DERIVATIVES, PROCESSES FOR THEIR PREPARATION AND USES THEREOF FOR THE TREATMENT OF CANCER

Lead Discovery Center Gmb...


1. A compound of the general formula (I)



wherein
R is —C1-C4-alkyl;
R1 is —H, or -methyl;
M is CH or N;
W is




whereinR2 is C1-C4-alkyl, -halogen, —CN;
X is -halogen, or —CN;
n=0, 1, or 2;

Y is —NR3R4 whereinR3 is —H, or —C1-C4-alkyl, and
R4 is —C1-C4-alkyl or —C3-C6-cycloalkyl; oran unsubstituted or substituted pyridine residue; or
an unsubstituted or substituted phenyl residue; or


Y is —NR3R4 with N, R3 and R4 forming an unsubstituted or substituted 5- or 6-membered saturated heterocycle; or
Y is —OR11, with R11 is —H or —C1-C4-alkyl;
or a pharmaceutically or veterinary acceptable salt, hydrate or solvate thereof.

US Pat. No. 11,111,237

BICYCLIC COMPOUND AND USE THEREOF

SK BIOPHARMACEUTICALS CO....


1. A compound of Formula 1, or an optical isomer, a stereoisomer or an isotopic variant thereof, or a pharmaceutically acceptable salt thereof:



wherein
X1 and X2 are each independently carbon or nitrogen;
Y is carbon, oxygen or nitrogen;
Z is carbon;
n is an integer of 0 or 1;
m is an integer of 0 to 2;
is a single bond or a double bond;
R1 is -D-R10; wherein D is a direct bond, —O—, —C(?O)—, —C?C— or —CR11R12—; R10 is hydrogen, halo, hydroxy, cyano, alkyl, hydroxyalkyl, haloalkyl, haloalkylsulfonate, dialkylamino, alkylaminoalkyl, dialkylaminoalkyl, dialkylaminocarbonylalkyl, saturated or unsaturated carbocyclyl, saturated or unsaturated heterocyclyl, saturated or unsaturated carbocyclyl-alkyl, or saturated or unsaturated heterocyclyl-alkyl; R11 and R12 are each independently hydrogen, hydroxy or alkyl; the carbocycle or heterocycle is optionally substituted with one or more substituents selected from hydroxy, halo, oxo, formyl (—CHO), nitrile, alkyl, alkoxy, hydroxyalkyl, hydroxyhaloalkyl, alkoxyalkyl, haloalkyl, nitrilealkyl, alkylcarbonyl, alkylthiocarbonyl, alkoxycarbonyl, haloalkylcarbonyl, carbocyclyl, carbocyclylcarbonyl, (alkyl)(haloalkyl)amino, (alkyl)(heterocyclyl)amino, heterocyclyl and heterocyclyl-alkyl;
R2 is hydrogen or alkyl;
R3 is hydrogen or alkyl;
R4, R5, R6 and R7 are each independently hydrogen or alkyl;
R8 is hydrogen, halo, alkyl, alkoxy or amino; and
R9 is hydrogen, halo or alkyl.

US Pat. No. 11,111,236

METHOD FOR PREPARING OXASPIROCYCLE DERIVATIVE, AND INTERMEDIATE THEREOF

Jiangsu Hengrui Medicine ...


1. A method for preparing a compound represented by formula D1 or a salt thereof,



comprising separating optical isomers of a compound represented by formula D or a salt thereof, by a chemical resolution method:




wherein,
R is aryl or heteroaryl, wherein the aryl or heteroaryl is optionally substituted by one or more substituents selected from the group consisting of alkyl, haloalkyl, halogen, amino, nitro, cyano, oxo, alkenyl, haloalkoxy, hydroxyalkyl, cycloalkyl, heterocyclyl, aryl, heteroaryl, OR3, C(O)R3, C(O)OR3, S(O)mR3 and NR4R5;
R3 is selected from the group consisting of hydrogen, alkyl, deuterated alkyl, amino, alkoxy, hydroxyalkyl, cycloalkyl, heterocyclyl, aryl and heteroaryl, wherein the alkyl, cycloalkyl, heterocyclyl, aryl and heteroaryl are optionally substituted by one or more substituents selected from the group consisting of alkyl, halogen, hydroxyl, amino, nitro, cyano, alkoxy, hydroxyalkyl, cycloalkyl, heterocyclyl, aryl and heteroaryl;
each of R4 and R5 is independently selected from the group consisting of hydrogen, alkyl, alkoxy, hydroxyalkyl, hydroxyl, amino, carboxylic ester group, cycloalkyl, heterocyclyl, aryl and heteroaryl, wherein the alkyl, cycloalkyl, heterocyclyl, aryl and heteroaryl are optionally substituted by one or more substituents selected from the group consisting of alkyl, halogen, hydroxyl, amino, carboxylic ester group, nitro, cyano, alkoxy, hydroxyalkyl, cycloalkyl, heterocyclyl, aryl and heteroaryl; and
m is 0, 1 or 2;
wherein a resolving agent is used in the chemical resolution method, and the resolving agent is a basic chiral resolving agent selected from the group consisting of S-phenylethylamine, quinidine, cinchonidine and arginine.

US Pat. No. 11,111,235

COMPOUNDS, COMPOSITIONS, AND METHODS

DENALI THERAPEUTICS INC.,...


1. A method for treating a disease or condition mediated, at least in part, by LRRK2, wherein the disease or condition is selected from the group consisting of kidney cancer, breast cancer, prostate cancer, blood cancer, papillary cancer, lung cancer, acute myelogenous leukemia, multiple myeloma, leprosy, Crohn's disease, inflammatory bowel disease, ulcerative colitis, rheumatoid arthritis, and ankylosing spondylitis, the method comprising administering to a subject in need thereof an effective amount of a compound of formula Ia:



or a pharmaceutically acceptable salt, deuterated analog, prodrug, stereoisomer, or a mixture of stereoisomers thereof, wherein:
R1 is optionally substituted cycloalkyl or C1-6 alkyl optionally substituted with halo;
R2 is halo, cyano, optionally substituted C1-6 alkyl, optionally substituted C2-6 alkenyl, optionally substituted C2-6 alkynyl, optionally substituted cycloalkyl, optionally substituted C1-6 alkoxy, optionally substituted cycloalkoxy, optionally substituted C1-6 alkylthio, optionally substituted C1-6 alkylsulfonyl, —C(O)R10, or —C(O)N(R11)(R12);
R3 is optionally substituted C1-6 alkoxy, optionally substituted cycloalkyl, optionally substituted cycloalkoxy, optionally substituted C1-6 alkylthio, optionally substituted C1-6 alkylsulfonyl, or —N(R11)(R12);
R4 is hydrogen or halo;
R6 and R7 are each independently hydrogen or C1-6 alkyl optionally substituted with halo;
R8 and R9 are each independently hydrogen, cyano, halo, optionally substituted C1-6 alkyl, optionally substituted C1-6 alkoxy, or optionally substituted heteroaryl;
R10 is optionally substituted C1-6 alkyl or optionally substituted C1-6 alkoxy; and
R11 and R12 are each independently hydrogen, optionally substituted C1-6 alkyl, or optionally substituted cycloalkyl.

US Pat. No. 11,111,233

AMINO PYRIMIDINE COMPOUND FOR INHIBITING PROTEIN TYROSINE KINASE ACTIVITY

Shenzhen TargetRx, Inc., ...


1. A compound of formula (III):



wherein,
R1 is selected from H, halo, —CN, optionally substituted C1-C6 alkyl, optionally substituted C1-C6 haloalkyl, or optionally substituted C3-C6 carbocyclyl;
R2 is selected from optionally substituted C1-C6 alkoxy, or optionally substituted C1-C6 haloalkoxy;
-(L)n-R6 is:




Y is the following structure:




wherein R3, R4 and R5 are independently selected from H, halo, —CN, optionally substituted C1-C6 alkyl or optionally substituted C1-C6 haloalkyl;
ring A is selected from the following structures:





R11 is independently selected from H, halo, —CN, C1-C6 alkyl, or optionally substituted C3-C6 carbocyclyl, as long as the chemistry permits; or, two adjacent R11 could be taken together to form optionally substituted C5-C8 carbocyclyl, or optionally substituted 5- to 8-membered heterocyclyl;or a pharmaceutically acceptable salt, a stereoisomer, a solvate, a hydrate, or an isotopically labeled compound thereof.

US Pat. No. 11,111,232

SUBSTITUTED CYCLOBUTYLPYRIDINE AND CYCLOBUTYLPYRIMIDINE COMPOUNDS AS INDOLEAMINE 2,3-DIOXYGENASE (IDO) INHIBITORS


1. A compound of formula (I), or a pharmaceutically acceptable salt thereof:



wherein:
each occurrence of A is independently selected from —CH? and N?; provided that at least one A group is —N? and at least one A group is —CH?;
L is selected from —NHC(O)— and —C(O)NH—;
W is selected from —C(O)NH— and —NHC(O)—;
R1 is selected from:(1) C1-6 alkyl,
(2) —O—C1-6 alkyl,
(3) C3-6 cycloalkyl,
(4) aryl, and
(5) heterocyclyl;

wherein each of the C1-6 alkyl of (1) and (2) is optionally substituted with 1-3 substituents independently selected from (a) halogen and (b) C3-6 cycloalkyl; and
wherein each of the C3-6 cycloalkyl of (3), aryl of (4), and heterocyclyl of (5) is optionally substituted with 1-3 substituents independently selected from (a) halogen, (b) —CN, (c) —O—C1-6 alkyl, and (d) C1-6 alkyl optionally substituted with 1-3 halogens;
R2 is selected from:(1) C1-6 alkyl,
(2) C3-6 cycloalkyl,
(3) aryl, and
(4) heterocyclyl;

wherein the C1-6 alkyl of (1) is optionally substituted with 1-3 substituents independently selected from (a) halogen and (b) C3-6 cycloalkyl; and
wherein each of the C3-6 cycloalkyl of (2), aryl of (3), and heterocyclyl of (4) is optionally substituted with 1-3 substituents independently selected from (a) halogen, (b) —CN, and (c) C1-6 alkyl optionally substituted with 1-3 halogens;

R3 is selected from H, halogen, —OH, and C1-6 alkyl optionally substituted with —OH; and each of R4 and R5 is independently selected from H, halogen, and C1-6 alkyl.

US Pat. No. 11,111,231

HETEROCYCLIC COMPOUND AND ORGANIC LIGHT-EMITTING DEVICE COMPRISING SAME

LG CHEM, LTD., Seoul (KR...


1. A compound represented by the following Chemical Formula 1:



in Chemical Formula 1,
L1 and L2 are the same as or different from each other, and are each independently a phenylene group unsubstituted or substituted by a fluorine group, a nitrile group, or an alkyl group of 1 to 50 carbon atoms,
X1 is N, X2 is N, and X3 is N,
A is a phenyl group unsubstituted or substituted by an alkyl group of 1 to 50 carbon atoms or a phenyl group; or a biphenyl group unsubstituted or substituted by an alkyl group of 1 to 50 carbon atoms or a phenyl group,
Ar1 and Ar2 are the same as or different from each other, and are each independently a phenyl group unsubstituted or substituted by an alkyl group of 1 to 50 carbon atoms or a phenyl group; a fluorenyl group unsubstituted or substituted by an alkyl group of 1 to 50 carbon atoms;
or a pyridyl group,
R1 to R4 are the same as or different from each other, and are each independently deuterium; a halogen group; a nitrile group; a nitro group; a hydroxy group; a substituted or unsubstituted alkyl group of 1 to 50 carbon atoms; a substituted or unsubstituted alkenyl group of 2 to 40 carbon atoms; a substituted or unsubstituted silyl group; a substituted or unsubstituted aryl group of 6 to 25 carbon atoms; or a substituted or unsubstituted aromatic or aliphatic heterocyclic group including one or more of N, O, and S atoms and 2 to 60 carbon atoms,
a and c are each an integer of 0 to 4, b and d are each an integer of 0 to 3, in the case where a is 2 or more, R1s are the same as or different from each other, in the case where b is 2 or more, R2s are the same as or different from each other, in the case where c is 2 or more, R3s are the same as or different from each other, and in the case where d is 2 or more, R4s are the same as or different from each other.

US Pat. No. 11,111,230

INDOLEAMINE 2,3-DIOXYGENASE INHIBITORS AND USE OF SAME IN MEDICINE

ADLAI NORTYE BIOPHARMA CO...


1. A compound represented by formula (I):



in free or pharmaceutically acceptable salt form,
wherein represents: , or ;
wherein A represents —C(O)—;
each R1 is respectively selected from halogen and C1-6alkyl;
Cy1 is




Ra, Rb, R2 are each independently hydrogen;
Cy2 is C5-C10 aryl with one substituent, wherein the substituent is selected from halogen, cyano, C1-6alkyl, and C1-6alkoxy;
m is 2, and
n is 0.

US Pat. No. 11,111,229

TETRAHYDROQUINOLINE COMPOSITIONS AS BET BROMODOMAIN INHIBITORS

FORMA Therapeutics, Inc.,...


1. A method of treating a disease or disorder mediated by one or more BET-family bromodomains in a patient, comprising administering to the patient in need thereof a compound:



or a pharmaceutically acceptable salt thereof.

US Pat. No. 11,111,227

ROTIGOTINE BEHENATE, AND MANUFACTURING METHOD AND APPLICATION THEREOF

Shandong Luye Pharmaceuti...


1. Rotigotine behenate, as shown in formula:




having melting point 48-52° C.

US Pat. No. 11,111,226

HYDROPHILIC COMPOUNDS FOR OPTICALLY ACTIVE DEVICES

Merck Patent GmbH, Darms...


1. A compound of formula (I)




whereina is 0 or 1;
a? is 0 or 1;
R1, R2 and R3 are at each occurrence independently H, F, Cl, Br, I, alkyl having from 1 to 20 carbon atoms, partially or completely halogenated alkyl having from 1 to 20 carbon atoms, aryl or heteroaryl;
one or both of R4 and R5 is a group of formula (II)




?and, if only one group of R4 and R5 is of formula (II) and a? is 1, the other of R4 and R5 H, F, Cl, Br, I, alkyl having from 1 to 20 carbon atoms, partially or completely halogenated alkyl having from 1 to 20 carbon atoms, aryl, heteroaryl, or R6—Sp-[X1]a—*; or
?one or both of R4 and R5 is a group of formula (II) and if only one group of R4 and R5 is of formula (II) and a? is 0, the other of R4 and R5 is R6?-Sp-[X1]a—*
R6? is a carbyl,

R6 is a carbyl group for a?=1 and for a?=0 is H;Sp is selected from the group consisting of alkanediyl, alkenediyl and alkyndiyl, wherein at least one hydrogen has been replaced with OH;
and wherein said alkanediyl, alkenediyl and alkyndiyl groups have 6-12 carbon atoms;
X1, X2 and X3 are independently of each other 0, S or N—R17;
R10, R11, R12, R13 and R14 are at each occurrence independently of each other H, F, Cl, Br, I, R6?-Sp-[x1]a-* and R15, wherein any two adjacent groups of R10, R11, R12, R13 or R14 that are R15 may also form a ring system;
R15 is at each occurrence independently alkyl having from 1 to 20 carbon atoms, partially or completely halogenated alkyl having from 1 to 20 carbon atoms, alkoxy having from 1 to 20 carbon atoms, partially or completely halogenated alkoxy having from 1 to 20 carbon atoms, thioalkyl having from 1 to 20 carbon atoms, or partially or completely halogenated thioalkyl having from 1 to 20 carbon atoms; and
R17 is at each occurrence independently H, F, Cl, Br, I, alkyl having from 1 to 20 carbon atoms, partially or completely halogenated alkyl having from 1 to 20 carbon atoms, aryl or heteroaryl,

provided that the compound of formula (I) comprises one group R6—Sp-[x1]a-*
wherein* each indicate the location of the linkage of the group containing the * to the rest of the compound.

US Pat. No. 11,111,225

CALIXARENE COMPOUND AND CURABLE COMPOSITION

DIC Corporation, Tokyo (...


1. A release agent that is a calixarene compound with a molecular structure represented by the following structural formula (1-1) or (1-2):



wherein, in structural formula (1-1) and (1-2):
R1 denotes a structural moiety represented by structural formula (2):—R4—Y—R4—RF??(2)

wherein, in structural formula (2):R4 independently denotes a direct bond or an alkylene group having 1 to 6 carbon atoms,
RF denotes a perfluoroalkyl group, and
Y denotes a carbonyl group, an oxygen atom, or a sulfur atom;

R2 denotes a structural moiety represented by:





wherein, in structural formula (3-1), (3-2), (3-4), (3-7), (4-1), (4-2), (4-3), (4-4), (4- 5), (4-6), or (4-7):R4 independently denotes an alkylene group having 1 to 6 carbon atoms,
R5 independently denotes an alkyl group having 1 to 3 carbon atoms,
and R6 denotes a hydrogen atom or a methyl group;


R3 denotes a hydrogen atom, an aliphatic hydrocarbon group that may have a substituent, or an aryl group that may have a substituent; and
n denotes an integer in the range of 4 to 10.

US Pat. No. 11,111,224

BENZOTHIA(DI)AZEPINE COMPOUNDS AND THEIR USE AS BILE ACID MODULATORS

Albireo AB, Gothenburg (...


1. A compound of formula (I)



whereinM is selected from —CH2— and —NR6—;
R1 is C1-4 alkyl;
R2 is independently selected from the group consisting of hydrogen, halogen, hydroxy, C1-4 alkyl, C1-4 haloalkyl, C1-4 alkoxy, cyano, nitro, amino, N—(C1-4 alkyl)amino, N,N-di(C1-4 alkyl)-amino, N-(aryl-C1-4 alkyl)amino, C1-6 alkylcarbonylamino, C3-6 cycloalkylcarbonylamino, N—(C1-4 alkyl)aminocarbonyl, N,N-di(C1-4 alkyl)aminocarbonyl, C1-4 alkyloxycarbonylamino, C3-6 cycloalkyloxycarbonylamino, C1-4 alkylsulfonamido and C3-6 cycloalkylsulfonamido;
n is an integer 1, 2 or 3;
R3 is selected from the group consisting of hydrogen, halogen, cyano, C1-4 alkyl, C3-6 cycloalkyl, C1-4 alkoxy, C3-6 cycloalkyloxy, C1-4 alkylthio, C3-6 cycloalkylthio, amino, N—(C1-4 alkyl)amino and N,N-di(C1-4 alkyl)amino;
One of R4 and R5 is carboxyl, and the other of R4 and R5 is selected from the group consisting of hydrogen, fluoro, C1-4 alkyl and C1-4 haloalkyl;
R6 is selected from the group consisting of hydrogen and C1-4 alkyl; and
R7 is selected from the group consisting of hydrogen and C1-4 alkyl;

or a pharmaceutically acceptable salt thereof.

US Pat. No. 11,111,222

HYDROXYEICOSATRIENOIC ACID COMPOUNDS AND THEIR USE AS THERAPEUTIC AGENTS

THE REGENTS OF THE UNIVER...


1. A compound of Formula (0), or a pharmaceutically acceptable salt thereof:



wherein:
A is —COOR1, —OSO3R1, —OPO3(R1)2, or -G-HET;
B is a bond each R1 independently is H or C1?6alkyl;
R2 is H or OH;
each —is a single or double bond, provided that (i) when —at bond 2 is a single bond, then —at bond 1 is a trans double bond and R2 is OH, and (ii) when —at bond 1 is a single bond, then —at bond 2 is a cis double bond and R2 is H;
HET is an unsubstituted or substituted 5 to 10-membered heteroaryl group having 1, 2, 3, or 4 heteroatoms selected from the group consisting of N, S, or O;
G is O, S, NH, or absent;
Cx is an alkylene group having x carbon atoms;
Cy is an alkyl group having y carbon atoms;
x is 3, 4, 5, 6, or 7;
y is 4, 5, 6, 7;
and each carbon atom of the compound of Formula (0) independently is unsubstituted or substituted with one or more deuterium or fluorine atoms;
with the proviso that when x is 6, y is 5, and each carbon atom of Formula (I) is unsubstituted, then A is not —COOH.

US Pat. No. 11,111,221

METHOD FOR THE INDUSTRIAL PRODUCTION OF 2-HALO- 4,6-DIALKOXY-L,3,5-TRIAZINES AND THEIR USE IN THE PRESENCE OF AMINES

CROSSING SRL, Treviso (I...


1. A method for the synthesis of 2-halo-4,6-dialkoxy-1,3,5-triazines of formula III:



wherein:
R1 and R2 are independently —CH3, —CH2CH3, —CH(CH3)2, —(CH2)2CH3, or —(CH2)3CH3, and
X is Cl? or Br?;
performed in the presence of water,
said method comprising the steps of:conducting a substitution reaction between the corresponding cyanuric trihalogenide C3N3X3, where X is Br? or Cl? (compound of formula I), and a linear or branched aliphatic alcohol, in single phase, in the presence of a base;
quenching the reaction by adding water and stirring;
performing filtration; and
drying,

wherein the molar ratio between the reagents: mol compound of formula I/mol base/mol water/mol alcohol is comprised between 1/6/7.7/4 and 1/7.9/10/4.1; wherein the substitution reaction is conducted at a temperature of between 45° C. and 135° C. for a time comprised between 5 h and 48 h.

US Pat. No. 11,111,220

PROPANAMINE DERIVATIVES FOR TREATING PAIN AND PAIN RELATED CONDITIONS

ESTEVE PHARMACEUTICALS, S...


1. A compound of general formula (I):




wherein:R1 and R?1 are independently selected from a hydrogen atom and a branched or unbranched C1-6 alkyl radical;
R2 is 6-membered aryl optionally substituted by a halogen atom, a branched or unbranched C1-6-alkyl radical, a branched or unbranched C1-6-alkoxy radical, a C1-6-haloalcoxy radical, a C1-6-haloalkyl radical or a hydroxyl radical; or a substituted or unsubstituted 5 or 6-membered heteroaryl having at least one heteroatom selected from N, O and S;
n is 1;
m is 0 or 1;
W is —(CH2)p—; —C(O)—; or a bond;
p is 1 or 2;
Z is NR3R4;
R3 is a hydrogen atom; a branched or unbranched C1-6 alkyl radical; a benzyl radical; or a phenyl radical;
R4 is a branched or unbranched C1-6 alkyl radical optionally substituted by a halogen atom, a hydroxyl radical, a branched or unbranched C1-6 alkoxy radical or a —NR4aR4b radical; a —(CH2)s-heteroaryl radical, wherein the heteroaryl group is a 5 or 6-membered ring having at least one nitrogen atom as heteroatom, optionally substituted by a —NR4cR4d radical, and s is 0, 1 or 2; a heterocycloalkyl radical optionally substituted by R4e; a —(CH2)r-aryl radical wherein the aryl group is 6-membered ring optionally substituted by at least one R5 radical, and r is 0, 1 or 2; or a —C(O)R5 radical;
R4a, R4b, R4c, R4d and R4e are independently selected from the group consisting of a hydrogen atom and a branched or unbranched C1-6 alkyl radical;
R5 is a hydrogen atom; a hydroxyl radical; a branched or unbranched C1-6-alkoxy radical; a —(CH2)j—NR5aR5b radical; a —NR5cR5d radical; or a 5-membered heteroaromatic ring having one or more N and/or O as heteroatoms, optionally substituted by R5e;
R5a, R5b, R5c, R5d and R5e are independently a hydrogen atom or a branched or unbranched C1-6 alkyl radical;
j is 0 or 1;
R6 is a branched or unbranched C1-6 alkyl radical; a —(CH2)q—NR6aR6b radical; a 5 or 6-membered nitrogen containing heteroaryl ring optionally having at least one additional heteroatom selected from O and N and optionally substituted by at least one R7; or a 6-membered aryl optionally substituted by at least one R8;
R6a and R6b are independently selected from the group consisting of a hydrogen atom and C1-6 alkyl;
q is 0, 1, 2, 3 or 4;
R7 is selected from the group consisting of a hydrogen atom, a branched or unbranched C1-6-alkoxy radical, a branched or unbranched C1-6-alkylthio radical; a —NR7aR7b radical; and a 5-membered heterocycloalkyl ring having at least one heteroatom selected from O, N and S;
R7a and R7b are independently selected from the group consisting of H and C1-6 alkyl;
R8 is a hydrogen atom, a halogen atom, a branched or unbranched C1-6-alkyl radical or a —(CH2)t—NR8aR8b radical;
t is 0 or 1;
R8a and R8b are independently selected from the group consisting of a hydrogen atom and a branched or unbranched C1-6 alkyl radical;
or a pharmaceutically acceptable salt, isomer, or solvate thereof.

US Pat. No. 11,111,219

POLYSUBSTITUTED PYRIMIDINES INHIBITING THE FORMATION OF PROSTAGLANDIN E2, A METHOD OF PRODUCTION THEREOF AND USE THEREOF

USTAV ORGANICKE CHEMIE A ...


1. Polysubstituted pyrimidines of the formula (I)




whereX1 is selected from the group consisting of —H, —F, —Cl, and alkyl;
X2 is selected from the group consisting of —H, —F, —Cl, and alkyl;
X3 is selected from the group consisting of —H, —F, —Cl, and alkyl;
X4 is selected from the group consisting of —H, —F, —Cl, and alkyl;
Y1 is selected from the group consisting of —H, —F, —Cl, and —OR, wherein R is alkyl;
Y2 is selected from the group consisting of —H, —F, —Cl, and —OR, wherein R is alkyl;
R1 is aryl as defined herein;
R2 is alkyl as defined herein;
or a pharmaceutically acceptable salt thereof,
wherein
alkyl in these cases is defined as a linear or branched C1-C10 carbon chain;
aryl in the above cases is defined as a hydrocarbon group containing 6 to 14 carbon atoms containing at least one aromatic ring, wherein the aryl may be unsubstituted or substituted with 1 to 5 substituents selected from the group of —F, —Cl, and —OR, wherein R is alkyl as defined herein.

US Pat. No. 11,111,218

CRYSTALLINE FORM OF 5-AMINO-2,3-DIHYDROPHTHALAZINE-1,4-DIONE


3. A pharmaceutical composition comprising the crystalline Form II according to claim 1 and at least one pharmaceutically acceptable excipient.

US Pat. No. 11,111,217

2-ARYLBENZIMIDAZOLES AS PPARGC1A ACTIVATORS FOR TREATING NEURODEGENERATIVE DISEASES

THE BOARD OF TRUSTEES OF ...


1. A pharmaceutical composition comprising a compound of formula:




or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier wherein the pharmaceutical composition is suitable for oral or parenteral administration.

US Pat. No. 11,111,216

POLYCATIONIC AMPHIPHILES AS ANTIMICROBIAL AGENTS AND METHODS USING SAME

Temple University-Of The ...


1. A compound selected from the group consisting of formula I-IV:



wherein in formula I-III:
R1, R2, and R3 are each independently selected from the group consisting of H or C1-C25 alkyl, wherein the alkyl group may be optionally substituted with —OR?, —NR?2, —NR?—C(O)R?, —C(O)NR?2, —NR?—C(O)CR??CR?, —SR?, —O—C(O)R?, —C(O)OR?, —C(O)R?, —CF3, —OCF3, halogen, benzyl, o-vinylbenzyl, m-vinylbenzyl, p-vinylbenzyl, phenyl, allyl, and substituted allyl, further wherein the alkyl group may optionally be interrupted with a —O—C(O)— group or a —C(O)O— group;
each occurrence of Ra, Rb, Rc, Rd, and Re is independently selected from the group consisting of H, C1-C6 alkyl, —OR?, —CN, —NO2, —NR?2, —N—C(O)R?, —C(O)NR?2, —N—C(O)CR??CR?, —SR?, —O—C(O)R?, —C(O)OR?, —C(O)R?, —CF3, —OCF3, and halogen;
each occurrence of R? is independently selected from the group consisting of H and C1-4 alkyl;
Y is N;
each occurrence of Z? is independently selected from the group consisting of Br? and I?;
m is an integer from 0 to 4;
n is an integer from 0 to 4; and
p is an integer from 0 to 4; and
wherein in formula IV:
R1 and R2 are each independently selected from the group consisting of H or C1-C25 alkyl, wherein the alkyl group may be optionally substituted with —OR?, —NR?2, —NR?—C(O)R?, —C(O)NR?2, —NR?—C(O)CR??CR?, —SR?, —O—C(O)R?, —C(O)OR?, —C(O)R?, —CF3, —OCF3, halogen, benzyl, o-vinylbenzyl, m-vinylbenzyl, p-vinylbenzyl, phenyl, allyl, and substituted allyl, further wherein the alkyl group may optionally be interrupted with a —O—C(O)— group or a —C(O)O— group, and each occurrence of Z? is I? when R1 and R2 are C12 alkyl;
each occurrence of Ra and Rb is independently selected from the group consisting of C1-C6 alkyl, —OR?, —CN, —NO2, —NR?2, —N—C(O)R?, —C(O)NR?2, —N—C(O)CR??CR?, —SR?, —O—C(O)R?, —C(O)OR?, —C(O)R?, —CF3, —OCF3, and halogen; when each occurrence of Rc, Rd, and Re is independently selected from the group consisting of H, C1-C6 alkyl, —OR?, —CN, —NO2, —NR?2, —N—C(O)R?, —C(O)NR?2, —N—C(O)CR??CR?, —SR?, —O—C(O)R?, —C(O)OR?, —C(O)R?, —CF3, —OCF3, and halogen; or
each occurrence of Ra and Rb is independently selected from the group consisting of H, C1-C6 alkyl, —OR?, —CN, —NO2, —NR?2, —N—C(O)R?, —C(O)NR?2, —N—C(O)CR??CR?, —SR?, —O—C(O)R?, —C(O)OR?, —C(O)R?, —CF3, —OCF3, and halogen; when each occurrence of Rc, Rd, and Re is independently selected from the group consisting of C1-C6 alkyl, —OR?, —CN, —NO2, —NR?2, —N—C(O)R?, —C(O)NR?2, —N—C(O)CR??CR?, —SR?, —O—C(O)R?, —C(O)OR?, —C(O)R?, —CF3, —OCF3, and halogen;
each occurrence of R? is independently selected from the group consisting of H and C1-4 alkyl;
each occurrence of Z? is independently selected from the group consisting of Br? and I?;
m is an integer from 0 to 4; and
n is an integer from 0 to 4.

US Pat. No. 11,111,215

PIPERIDINE-BASED STABILIZERS AND POLYMERS END-CAPPED WITH THE SAME

SOLVAY SPECIALTY POLYMERS...


1. An end-capper stabilizer compound (EC) of the general structural formula (I):



wherein:
Rk is selected from the group consisting of —H, aliphatic groups, and alkoxy groups, and
Rj groups are equal to or different from each other and from Rk and are independently selected from aliphatic groups, and
Y is a monovalent group selected from a first group consisting of a halogen, a carboxylic ester, an acid halide, an anhydride, an amide, and a thioester or from a second group consisting of a hydroxyl, an amine, a carboxylic acid, a thiol, and any protected derivative thereof, and
A is a divalent group of formula:





US Pat. No. 11,111,214

KAPPA OPIOID AGONISTS AND USES THEREOF

Nektar Therapeutics, San...


12. A compound having the structure:




wherein R10 is selected from the group consisting of ˜H, ˜OCH2CH2OH, ˜OCH2CH2OCH3, ˜NHCH2CH2OH, and ˜NHCH2CH2OCH3,
X is an optional linker selected from a covalent bond; —C(O)NH—; —C(O)NHCH2—;—C(O)NHCH2CH2—; —OC(O)NH—; —C(O)NH—; —O—; —NHC(O)—; and —NHC(O)CH2—;

POLY is a poly(alkylene oxide) oligomer comprising 2 to 10 alkylene oxide monomers, or pharmaceutically acceptable salts and solvates thereof.

US Pat. No. 11,111,213

METHOD FOR PRODUCING METHIONINE

SUMITOMO CHEMICAL COMPANY...


1. A method for producing methionine comprisinga) a crystallization step in which carbon dioxide is introduced into a reaction solution containing an alkali metal salt of methionine, which is obtained by hydrolyzing 5-[2-(methylthio)ethyl] imidazolidine-2,4-dione in the presence of an alkali compound selected from the group consisting of potassium hydroxide, sodium hydroxide, potassium carbonate, and potassium hydrogencarbonate, to precipitate methionine,
b) a step of subjecting the reaction solution containing precipitated methionine resulting in the crystallization step to a solid-liquid separation to obtain methionine and mother liquor,
c) a step of recovering methionine from the mother liquor by filtration,
d) a step of drying the methionine obtained by step c) to obtain dried methionine, wherein the drying step also produces an exhaust,
e) a step of sieving the dried methionine to obtain sieved methionine,
f) a step of packaging the sieved methionine powders to obtain a packaged methionine product, and
g) a step of transporting methionine between each of the steps c) to f),
wherein the method comprises a step of adding waste methionine to the reaction solution, wherein the waste methionine supplied to the hydrolysis reaction solution includes
recovered methionine in step c), and
at least one recovered methionine selected from the group consisting of
methionine discharged out of the system due to exhaust in the drying step,
fine powdered methionine passed through a sieve mesh in the sieving step,
methionine that is soared when filling a container with methionine in the product packaging step, and
methionine lost during any of the transporting steps.

US Pat. No. 11,111,211

METHOD OF DISTILLING DIMETHYL SULFOXIDE AND MULTISTAGE DISTILLATION TOWER

Toray Fine Chemicals Co.,...


1. A method of distilling a liquid containing dimethyl sulfoxide using a single multistage distillation tower, comprising:(1) contacting sodium carbonate and a liquid containing dimethyl sulfoxide at a bottom portion of the distillation system such that sodium carbonate accounts for 0.005% to 25% by weight relative to 100% by weight of the liquid containing dimethyl sulfoxide and sodium carbonate in total at the bottom portion of the single multistage distillation tower and heating the bottom portion with a heater, wherein sodium carbonate is directly added at the bottom Portion of the single multistate distillation tower; and
(2) obtaining a distillate containing dimethyl sulfoxide at a position lower than a position at which the liquid containing dimethyl sulfoxide is introduced and higher than a position of the heater.

US Pat. No. 11,111,210

PHENYL CYCLOHEXANONE DERIVATIVES AND METHODS OF MAKING AND USING THEM

SPIRIFY PHARMA INC., Sad...


1. A phenyl cyclohexanone compound of Formula I or pharmaceutically acceptable salt thereof:



R1 is —NH2 or —OH;
R2 is,




where Rx is Cl, Br, —OCH3, or NH2;
R3 is —OH, —OCH3, —NH2, —CN, —SO2—NH2,




R4 is —OH, or —OCH3; and
R5 is —OH, —NH2, or ?O.

US Pat. No. 11,111,208

PROCESS FOR THE PREPARATION OF SAFINAMIDE MESYLATE INTERMEDIATE

RK PHARMA SOLUTIONS LLC, ...


1. A method for the preparation of a compound, comprising:a condensation reaction of 4-hydroxybenzaldehyde of formula II with 1-(chloromethyl)-3-fluorobenzene of formula III, using potassium carbonate, and potassium iodide in a solvent, and removing the solvent after completion of the condensation reaction, therewith producing crude 4-((3-fluorobenzyl)oxy)benzaldehyde of formula IV;
treating the crude with n-heptane to remove genotoxic impurities;
dissolving the treated crude in dichloromethane and treating the solution with potassium carbonate; and
treating the treated solution with n-heptane to afford 4-((3-fluorobenzyl)oxy)benzaldehyde of formula V having a purity greater than 99%.

US Pat. No. 11,111,206

MONOMERS AND POLYMERS FORMED THEREBY

Regents of the University...


1. A polymer formed from one or more monomers of formula I



wherein R1 is a C1 to C4 alkyl; and
X is —OR2 where R2 is a C1 to C4 alkyl, 2-ethylhexyl, or a hydrocarbon moiety of bio-renewable alcohol or a hydrogenated derivative thereof.

US Pat. No. 11,111,203

SYSTEM AND METHOD FOR MANUFACTURING ESTER-BASED COMPOSITION

LG Chem, Ltd., Seoul (KR...


1. A system for manufacturing an ester-based composition, the system comprising:a mixer in which a reaction mixture of a polycarboxylic acid and a first alcohol having 3 to 10 alkyl carbon atoms is formed, wherein the mixer comprises a polycarboxylic acid injection path and a first alcohol injection path;
a reaction unit provided with N number of batch reactors connected in parallel in which an esterification reaction of the reaction mixture is performed, an inlet line for receiving the reaction mixture from the mixer, and an outlet line for discharging reaction products from the N number of batch reactors;
a supply control unit for controlling the injection amount and the injection path of the reaction mixture such that the reaction mixture is sequentially supplied to the N number of batch reactors from the mixer to allow the reaction to be sequentially completed, wherein the supply control unit is disposed between the mixer and the reaction unit; and
a separation unit for receiving the reaction products through the outlet line of the reaction unit and removing unreacted alcohol therefrom.

US Pat. No. 11,111,202

PRODUCTION OF SALTS OF 4-HYDROXYBUTYRATE USING BIOBASED RAW MATERIALS

CJ CHEILJEDANG CORPORATIO...


1. A method for producing a sample from an approved source, said method comprising:fermenting engineered microbes which produce poly(4-hydroxybutyrate) (P4HB) polymer with a growth medium comprising D2O with deuterated glucose or without deuterated glucose to produce a deuterated P4HB;
reacting the deuterated P4HB for obtaining a deuterated gamma-butyrolactone, a deuterated 4-hydroxybutyrate, an oligomer of deuterated 4-hydroxybutyrate, or a combination thereof; and
mixing the reacted deuterated P4HB with a gamma-butyrolactone prepared from petroleum-based starting materials, a 4-hydroxybutyrate prepared from petroleum-based starting materials, an oligomer of 4-hydroxybutyrate prepared from petroleum-based starting materials, or a combination thereof to prepare a mixture of GBL, a mixture of GHB, a mixture of oligomers of 4-hydroxybutyrate, or a mixture comprising a combination thereof, wherein the mixture has a chosen percent modern carbon range,
wherein the growth medium comprises a selected mixture of a biobased material and a petroleum-based material to yield a desired percent modern carbon, wherein a percentage of the carbon in the deuterated P4HB is modern carbon and the remaining percentage of carbon is fossil-carbon, wherein the chosen percent modern carbon range is controlled to provide a unique carbon footprint, and wherein the chosen percent modern carbon range corresponds to a defined range of the approved source,
wherein the growth medium comprises a concentration of D2O above the natural abundance in water, and
wherein the deuterated P4HB produced by fermenting is 27% to 80% deuterated.

US Pat. No. 11,111,200

METHOD FOR PREPARING ACRYLIC ACID AND METHYL ACRYLATE

Dalian Institute of Chemi...


1. A method, for preparing acrylic acid and methyl acrylate, the method comprising passing a feed gas containing dimethoxymethane and carbon monoxide through a reactor loaded with a molecular sieve catalyst to carry out a reaction, to generate acrylic acid and methyl acrylate, methyl acetate and acetic acid;wherein the esters produced by the method are further hydrolyzed to produce the corresponding carboxylic acids, including the hydrolysis of the methyl acrylate to produce the corresponding acrylic acid, and the hydrolysis of the methyl acetate to produce the corresponding acetic acid.

US Pat. No. 11,111,198

HYDROFORMYLATION PROCESS

Dow Technology Investment...


1. A hydroformylation process for producing an aldehyde, the process comprising: contacting in a reaction zone reactants comprising an olefin, hydrogen and CO in the presence of a rhodium-organophosphite based catalyst, optionally with free organophosphite ligand, and 0.1 to 3 weight percent, based on the total weight of the fluid in the reaction zone, of at least one polymer having the structure of Formula (I) or Formula (II), respectively:




wherein R21 and R22 are the same or different C1 to C16 alkyl or alkyl-substituted aryl moieties and m, n, and q are positive numbers or zero whose sum is greater than 50 and p is 3 to 6 inclusive, wherein the polymer average molecular weight is equal to or above 10,000, wherein R23 and R24 are H or a C1 to C4 alkyl moiety, wherein R25 is H or a C1 to C16 alkyl moiety, and wherein R25 can be the same or different for each p moiety within Formula (II), such that the solubility of the polymer in the aldehyde is greater than or equal to 1 weight percent at 40° C.

US Pat. No. 11,111,197

PROCESS FOR THE PREPARATION OF ALPHA, BETA UNSATURATED ALDEHYDES BY OXIDATION OF ALCOHOLS IN THE PRESENCE OF A LIQUID PHASE

BASF SE, Ludwigshafen am...


1. A process for the preparation of alpha, beta unsaturated aldehydes of general formula (I)



wherein R1, R2 and R3, independently of one another, are selected from
hydrogen; C1-C6-alkyl, which optionally carry 1, 2, 3, or 4 identical or different substituents which are selected from NO2, CN, halogen, C1-C6 alkoxy, (C1-C6-alkoxy)carbonyl, C1-C6 acyl, C1-C6 acyloxy and aryl; and C2-C6-alkenyl, which optionally carry 1, 2, 3, or 4 identical or different substituents which are selected from NO2, CN, halogen, C1-C6 alkoxy, (C1-C6-alkoxy)carbonyl, C1-C6 acyl, C1-C6 acyloxy and aryl;
by oxidation of alcohols of general formula (II)




wherein R1, R2 and R3 have the meaning as given above
in the presence of a catalyst and in the presence of a liquid phase,wherein the liquid phase contains at least 25 weight-% water based on the total weight of the liquid phase, determined at a temperature of 20° C. and a pressure of 1 bar and
wherein the oxidant is oxygen, and
wherein the catalyst comprises a catalytically active metal on a support and the catalytically active metal is located mainly in the outer shell of the catalyst, wherein the outer shell of the catalyst is the space from the outer surface of the catalyst to a depth of X from the outer surface of the catalyst, wherein X is 15 % of the distance from the outer surface of the catalyst to the center of the catalyst.


US Pat. No. 11,111,196

1,2-DICHLORO-1-(2,2,2-TRIFLUOROETHOXY)ETHYLENE, PRODUCTION METHOD THEREFOR, AND USES THEREOF

KANTO DENKA KOGYO CO., LT...


1. 1,2-Dichloro-1-(2,2,2-trifluoroethoxy)ethylene represented by the following formula (1)




US Pat. No. 11,111,195

BIO-METHANOL PRODUCTION

Ultra Clean Ecolene Inc.,...


1. A method for producing bio-methanol, comprising:supplying biomass to an anaerobic digester for producing biogas comprising methane and carbon dioxide;
supplying the biogas and oxygen sourced from water to a partial oxidation unit to produce syngas;
supplying the syngas with hydrogen sourced from water to a synthesis unit and producing the bio-methanol;
supplying distilled water to a water electrolysis unit to produce electrolysis oxygen and electrolysis hydrogen;
supplying at least a portion of the electrolysis hydrogen as at least part of the hydrogen used in the synthesis unit;
supplying at least a portion of the electrolysis oxygen as at least part of the oxygen used in the partial oxidation unit; and
powering the electrolysis unit using different sources of energy, wherein:during electricity demand of an electrical grid below a base threshold, the electrolysis unit is powered using energy from the electrical grid and a battery is charged from the electrical grid, and
during electricity demand of the electrical grid over a base threshold, the electrolysis unit is powered at least in part using energy stored in the battery.


US Pat. No. 11,111,194

ODH COMPLEX WITH ON-LINE MIXER UNIT AND FEED LINE CLEANING

NOVA CHEMICALS (INTERNATI...


1. A chemical complex for the oxidative dehydrogenation of lower alkanes, the chemical complex comprising in cooperative arrangement:i) at least two mixers for premixing an oxygen containing gas and a lower alkane containing gas to produce a mixed feedstock stream and additionally comprising a cleaning loop; and
ii) at least one oxidative dehydrogenation reactor;
wherein the at least two mixers are connected in parallel to the at least one oxidative dehydrogenation reactor so that either a first gas mixing unit or a second gas mixing unit is connected to the at least one oxidative dehydrogenation reactor during normal operations; and
wherein an oxidative dehydrogenation catalyst contained within the at least one oxidative dehydrogenation reactor reacts with the mixed feed stock stream to produce a product stream comprising the corresponding alkene.

US Pat. No. 11,111,192

METHODS AND SYSTEMS FOR PRODUCING PARA-XYLENE FROM C8-CONTAINING COMPOSITIONS

Saudi Arabian Oil Company...


1. A system for producing para-xylene (PX) from a C8 aromatic-containing composition, the system comprising:a xylene rerun column operable to separate the C8 aromatic-containing composition into a xylene-containing effluent and a heavy effluent, the xylene-containing effluent comprising at least PX and one or more of ortho-xylene (OX), meta-xylene (MX), ethylbenzene (EB), or combinations of these;
a xylene processing loop comprising:a PX recovery unit operable to separate the xylene-containing effluent into at least a PX product and a PX-depleted effluent;
an ethylbenzene dealkylation unit directly downstream of the PX recovery unit so that the PX-depleted effluent passes directly from the PX recovery unit to the ethylbenzene dealkylation unit, and operable to dealkylate at least a portion of the EB from the PX-depleted effluent to produce a dealkylation effluent comprising one or more C7? compounds;
a stripper disposed directly downstream of the ethylbenzene dealkylation unit, the stripper operable to separate the dealkylation effluent into a C7? effluent, an EB-depleted effluent, and a stripper bottoms;
a membrane isomerization unit disposed downstream of the stripper and operable to receive the EB-depleted effluent from the stripper and convert at least a portion of the MX, OX, EB, or combinations of these, in the EB-depleted effluent to PX to produce an isomerate; and
a membrane separation unit operable to separate the isomerate into a permeate that is PX-rich and a retentate that is PX-lean;
where the stripper is fluidly coupled to the xylene rerun column to recycle the stripper bottoms back to the xylene rerun column.


US Pat. No. 11,111,191

METHOD FOR PREPARING HEXADECAHYDROPYRENE

FUSHUN RESEARCH INSTITUTE...


1. A method for preparing hexadecahydropyrene, comprising:hydrogenating a hydrocarbon oil raw material that contains pyrene compounds in the presence of a first hydrogenation catalyst in a first reactor;
hydrogenating an effluent from the first reactor in the presence of a second hydrogenation catalyst in a second reactor;
separating an effluent from the second reactor to obtain a product stream comprising hexadecahydropyrene;
cooling the product stream; and
separating hexadecahydropyrene from the cooled product stream,

wherein the pyrene compounds are selected from at least one of pyrene and unsaturated hydrogenation products thereof,
wherein each of the first hydrogenation catalyst and the second hydrogenation catalyst comprises a carrier and an active metal component loaded on the carrier,
wherein the active metal component is Pt, Pd, or Pt and Pd, the carrier comprises a small crystal size Y zeolite, alumina, and amorphous silica-alumina, wherein the small crystal size Y zeolite has an average grain diameter of 200-700 nm, a molar ratio of SiO2/Al2O3 of 40-120, a relative crystallinity of ?95%, a specific surface area of 900-1,200 m2/g, and a pore volume of secondary pores having 1.7-10 nm in diameter that accounts for 50% or more of a total pore volume, and
wherein a weight percentage of the active metal component in the first hydrogenation catalyst (x1) is lower than a weight percentage of the active metal component in the second hydrogenation catalyst (x2), and a weight percentage of the small crystal size Y zeolite in the first hydrogenation catalyst (y1) is higher than a weight percentage of the small crystal size Y zeolite in the second hydrogenation catalyst (y2), wherein x1 and y1 are based on a total weight of the first hydrogenation catalyst, and x2 and y2 are based on a total weight of the second hydrogenation catalyst.

US Pat. No. 11,111,188

CONTAINER-BASED COMPOSTING

Timothy G. Shuttleworth, ...


1. A composting kit, comprising:a roll-off container;
a perforated aeration conduit defining a first axis, wherein the perforated aeration conduit comprises a first end, a second end, and a central cylindrical conduit along the first axis between the first end and the second end;
a delivery conduit defining a second axis, wherein the delivery conduit is configured to be fluidically coupled to the first end of the perforated aeration conduit at a releasable joint; and
a blower configured to be fluidically coupled to the delivery conduit;
wherein the composting kit is configured to be assembled into a working configuration in which the perforated aeration conduit extends along a lower support surface within the roll-off container, wherein the second axis traverses the first axis when the composting kit is in the working configuration, and wherein the blower is configured to provide air to the perforated aeration conduit when the composting kit is in the working configuration.

US Pat. No. 11,111,187

PRODUCTION METHOD FOR FULVIC ACID SOLUTION, AND FULVIC ACID SOLUTION

G-8 International Trading...


10. A fulvic acid solution production method comprising:an apparatus preparation step of preparing a processing apparatus which comprises: a hermetic container internally having a closeable processing space; a steam jetting device operable to jet high-temperature and high-pressure steam into the hermetic container; a supply section having an opening-closing mechanism and operable to supply a raw material into the hermetic container; a stirring device for stirring the raw material supplied into the hermetic container; and a discharge section having an opening-closing mechanism and operable to discharge, to the outside, a processed liquid produced through processing of the raw material by the steam;
a raw material input step of inputting a plant raw material comprised of a gramineous plant as a primary raw material, from the supply section into the processing space of the hermetic container of the processing apparatus;
a processing step of subjecting the raw material to a subcritical water reaction processing, under stirring, while introducing steam having a temperature of 100 to 200° C. and a pressure of 5 to 25 atm into the processing space in which the raw material is input, to obtain a mixed solution containing fulvic acid and humic acid; and
a fulvic acid solution taking-out step of separating fulvic acid from the obtained mixed solution to take out a fulvic acid solution.

US Pat. No. 11,111,186

ACID COMPOSITION BASED ON LEONARDITE AND AMINO ACIDS

SIPCAM INAGRA, S.A., Val...


1. An aqueous acid solution comprising: leonardite micronized in the aqueous solution comprising surfactants, wherein the solution further comprises amino acids, the solution being for use as at least one of a fertiliser, a biostimulant, and a nutrient, wherein the solution comprises a micronized aqueous dispersion, and wherein the leonardite and amino acids do not precipitate from the solution nor from field application in which the aqueous solution applied has a neutral or acidic pH, and wherein the solution has stable fluidity for up to 14 days.

US Pat. No. 11,111,185

ENHANCED BIOCHAR

Carbon Technology Holding...


21. A plurality of porous carbonaceous particles, wherein the plurality of porous carbonaceous particles meets EU Feed limit for dioxins of at most 0.75 ng/kg WHO-PCDD/F-TEQ//kg.

US Pat. No. 11,111,184

METHOD FOR ADDITIVE MANUFACTURING OF 3D-PRINTED ARTICLES

KAOHSIUNG MEDICAL UNIVERS...


1. A method for additive manufacturing a 3D-printed article, comprising:(a) printing and depositing one or more layers of a slurry by using a 3D printer to obtain a printed ceramic object, wherein the slurry comprises a ceramic powder composition;
(b) covering outer periphery of the printed ceramic object with an oil; and
(c) sintering the oil-covered printed ceramic object from step (b) by heating to obtain the 3D-printed article wherein the temperature of a printing carrier of the 3D printer is from 30 to 80° C.

US Pat. No. 11,111,182

CERAMIC SINTERED BODY

TUNGALOY CORPORATION, Iw...


1. A ceramic sintered body containing aluminum oxide, tungsten carbide and zirconium oxide, wherein:the zirconium oxide contains ZrO and ZrO2;
the ZrO2 has a crystal structure or structures of one or two kinds selected from the group consisting of a tetragonal crystal structure and a cubic crystal structure;
based on a total content of the ceramic sintered body:a content of the aluminum oxide is from 30 volume % or more to 74 volume % or less;
a content of the tungsten carbide is from 25 volume % or more to 69 volume % or less; and
a content of the zirconium oxide is from 1 volume % or more to 20 volume % or less; and

when, in X-ray diffraction, regarding a peak intensity for a (111) plane of the ZrO as being denoted by I1, regarding a peak intensity for a (101) plane of ZrO2 having a tetragonal crystal structure as being denoted by I2t, and also regarding a peak intensity for a (111) plane of ZrO2 having a cubic crystal structure as being denoted by I2c, a ratio of I1 based on a total of I1, I2t and I2c [I1/(I1+I2t+I2c)] is from 0.05 or more to 0.90 or less.

US Pat. No. 11,111,181

CEMENT WITH REDUCED PERMEABILITY

RESTONE AS, Fyllingsdale...


1. A cementitious mixture for reduced gas permeability that comprises:a) an alkaline cement;
b) one or more divalent magnesium-iron silicates of the mineral group olivines that in neutral or basic aqueous solutions is a latent hydraulic binder comprising 2% to 99% of divalent magnesium-iron silicate by weight of total hydraulic solid materials.

US Pat. No. 11,111,176

METHODS AND APPARATUS OF PROCESSING TRANSPARENT SUBSTRATES

APPLIED MATERIALS, INC., ...


1. A film stack for optical devices, comprising:a glass substrate comprising a first surface and a second surface, the second surface opposing the first surface and the first surface being disposed above the second surface;
a device function layer formed on the first surface;
a hard mask layer formed on the device function layer, the hard mask layer comprising one or more of chromium, ruthenium, or titanium nitride;
a substrate recognition layer formed on the hard mask layer; and
a backside layer formed on the second surface, the backside layer comprising one or more of a conductive layer or an oxide layer.

US Pat. No. 11,111,175

HYDROPHOBIC WINDOW, HOUSE AND VEHICLE USING THE SAME

Tsinghua University, Bei...


1. A hydrophobic window, the hydrophobic window comprising:a window frame;
a glass embedded in the window frame; and
a hydrophobic film on a surface of the glass, wherein the hydrophobic film comprises:a flexible substrate, wherein the flexible substrate comprises a flexible base and a patterned first bulge layer on a surface of the flexible base; wherein the patterned first bulge layer comprises a plurality of strip-shaped bulges intersected with each other to form a net shaped structure and a plurality of first holes are formed between the plurality of strip-shaped bulges, and each of the plurality of strip-shaped bulges has a height in a range from about 75 nanometers to about 800 nanometers; and
a hydrophobic layer on a surface of the patterned first bulge layer opposite to the flexible base.


US Pat. No. 11,111,174

MINERAL FIBER ROOF COVER BOARDS

UNITED STATES GYPSUM COMP...


1. A composite roofing structure comprising:a roof cover board that comprises a dried base mat comprising:about 8 wt % to about 25 wt % mineral wool,
about 40 wt % to about 65 wt % perlite,
9 wt % to 15 wt % starch binder and/or latex binder,
about 9 wt % to about 15 wt % cellulosic fiber, and
0.25 wt % to 2.0 wt % sizing agent,
wherein the dried base mat has an absence of bituminous material;
a layer of insulation; and
a layer of waterproof roofing membrane;
wherein the roof cover board is over the layer of insulation, the roofing membrane is over the roof cover board, the roof cover board is attached to the layer of insulation, and the waterproof roofing membrane is attached to the roof cover board.


US Pat. No. 11,111,172

BASIC ADDITIVES FOR SILICA SOOT COMPACTS AND METHODS FOR FORMING OPTICAL QUALITY GLASS

Corning Incorporated, Co...


1. A method of forming optical quality glass, the method comprising:contacting silica soot particles with a basic additive such that a pH of the silica soot particles increases to between about 8.0 and about 9.0,the silica soot particles containing between about 0.1 wt % and about 5.0 wt % water, and
the basic additive being in a concentration of less than about 5.0% by weight of the silica soot particles;

forming a silica soot compact; and
removing the basic additive from the silica soot compact, wherein the silica soot compact has a density of less than about 1.00 g/cm3.

US Pat. No. 11,111,171

OPTICAL FIBER, METHOD FOR MANUFACTURING OPTICAL FIBER, AND OPTICAL FIBER PREFORM

Fujikura Ltd., Tokyo (JP...


1. An optical fiber comprising:a core; and
a cladding layer disposed on an outer circumference of the core, wherein
the core is formed of silicon dioxide that does not contain germanium,
the cladding layer includes an inner cladding layer and an outer cladding layer disposed outside of the inner cladding layer,
a refractive index of the outer cladding layer is higher than a refractive index of the inner cladding layer,
an average Cl concentration distribution across a cross section of the cladding layer is 0.029 wt% to 0.098 wt%, and
?2??1<0 dB/km is satisfied at a wavelength of 430 nm, where ?1 is a value of transmission loss before exposure of the optical fiber to hydrogen and ?2 is a value of transmission loss after the exposure to pure hydrogen for at least 15 hours.

US Pat. No. 11,111,170

LASER CUTTING AND REMOVAL OF CONTOURED SHAPES FROM TRANSPARENT SUBSTRATES

CORNING INCORPORATED, Co...


1. A method of cutting an article from a substrate, comprising:focusing a pulsed laser beam into a laser beam focal line;
directing the laser beam focal line into the substrate at a first plurality of locations along a first predetermined path, the laser beam focal line generating an induced absorption within the substrate that produces a defect line within the substrate along the laser beam focal line at each location of the first plurality of locations, wherein the first predetermined path is a closed path;
heating the substrate along the first predetermined path to propagate a crack through each defect line of the first plurality of locations to form a cleave that extends completely through the substrate along the first predetermined path, thereby completely isolating an interior plug from the substrate; and
heating the interior plug after the isolating such that at least a portion of the interior plug is heated to a temperature equal to or greater than a softening temperature of the substrate; and
allowing the interior plug to cool after the heating to remove the plug from the substrate.

US Pat. No. 11,111,169

MOLD SHUTTLE POSITIONING SYSTEM FOR A GLASS SHEET FORMING SYSTEM

GLASSTECH, INC., Perrysb...


1. A mold shuttle positioning system for positioning a hot glass sheet in multiple locations within a glass sheet heating and forming system comprising:a mold including a surface that defines a shape to which the glass sheet is to be initially formed;
a mold support frame including at least one connection surface for mounting the mold thereon;
a movable shuttle frame that is movable in a generally horizontal direction, the movable shuttle frame including a pair of elongate beams that are generally parallel, each of the elongate beams including a support surface near one end of the elongate beam for receiving and supporting the mold support frame thereon;
at least one mold guide mounted on the support surface of one of the elongate beams for fixing position of the mold support frame relative to the movable shuttle frame to prevent movement of the mold support frame with respect to the movable shuttle frame in any direction as the mold support frame is supported thereon, and at least one other mold guide mounted on the support surface of an other one of the elongate beams for fixing the position of the mold support frame relative to the movable shuttle frame to prevent movement of the mold support frame in a first direction with respect to the movable shuttle frame, but allow movement of the mold support frame in a second direction with respect to the movable shuttle frame as the mold support frame is supported thereon;
at least one support wheel assembly mounted to position and support each one of the elongate beams as the movable shuttle frame is moved to position the mold at one of multiple desired processing locations, each support wheel assembly including a support wheel and an actuator for selectively moving the support wheel and the elongate beam supported thereon in a generally vertical direction; and
at least one shuttle guide mounted on at least one of the support wheel assemblies associated with only one of the elongate beams for receiving the movable shuttle frame and fixing the position of the movable shuttle frame relative to the glass sheet heating and forming system to locate and prevent movement of the movable shuttle frame in a first direction with respect to the glass sheet heating and forming system, but allow movement of the movable shuttle frame in a second direction with respect to the glass sheet heating and forming system as the movable shuttle frame and mold are positioned for processing the glass sheet in multiple locations within the glass sheet heating and forming system.

US Pat. No. 11,111,168

TANK WITH MEMBRANE COVER AND DRAFT TUBE MIXER

Ovivo Inc., Montreal (CA...


1. A wastewater treatment system including an anaerobic digester, the digester having a tank with a rim, comprising:a membrane gas cover on top of the tank and covering the tank, connected to and sealed to the tank rim to be inflated and contain gas therein,
an interruption in the gas cover at least at one location around the periphery of the tank, with a platform secured to the tank rim at the interruption, the platform including a substantially horizontal surface, the gas cover at said interruption having edges on each side of the interruption connected in substantially sealed relationship to the platform, and
a draft tube mixer secured to the platform and extending down through an opening in said horizontal surface, the draft tube mixer including a draft tube secured to the platform and to the tank, fixedly secured therein, and a mixing mechanism having a shaft and an impeller removably fitted in the draft tube, with the impeller and shaft extending down into the draft tube and a drive mechanism connected to the shaft and secured at the top of the draft tube, the draft tube having openings above and below the impeller, for drawing in sludge from within the tank and expelling the sludge in a desired direction, thus circulating and mixing the sludge in the tank.

US Pat. No. 11,111,167

CONTROL OF A CENTRALIZED AIR PRODUCTION SYSTEM FOR A WASTEWATER TREATMENT PLANT


1. A system for supplying air to at least one biological water treatment basin, said system comprising:at least one air production machine;
at least one air distribution system of the at least one biological water treatment basin, said system comprising:
an air distribution means connecting the at least one air production machine to the at least one biological water treatment basin;
a first control means for controlling the pressure of the at least one air production machine, said first control means receiving a pressure value from the air distribution means and a time-variable setpoint determined from a prediction of an air demand of the at least one biological water treatment basin and delivering, in response, a pressure value sent as a pressure setpoint to the at least one air production machine.

US Pat. No. 11,111,166

METHOD FOR MAKING FIBROUS NANOPARTICLE-CONTAINING FILTER

King Abdulaziz University...


1. A method of making a fibrous nanoparticle-containing filter, comprising:mixing a colloidal suspension comprising silver nanoparticles, polyvinylpyrrolidone, and dimethylformamide with a ketone-based solvent to form a precursor suspension;
mixing polyvinylidene fluoride with the precursor suspension to form a first suspension;
separately mixing polymethylmethacrylate with the precursor suspension to form a second suspension;
mixing the first suspension with the second suspension to form an electrospin suspension; and
electrospinning the electrospin suspension through a syringe needle at an applied voltage of from 12 to 30 KV to form the fibrous nanoparticle-containing filter,
wherein the fibrous nanoparticle-containing filter comprises polymer fibers comprising polymethylmethacrylate, polyvinylidene fluoride, and polyvinylpyrrolidone, and silver nanoparticles deposited on the polymer fibers.

US Pat. No. 11,111,165

PROCESS AND APPARATUS FOR TREATING WATER

INFINITE WATER TECHNOLOGI...


1. A process for treating water containing contaminants comprising the sequential steps of:(a) in a first vessel a first oxidation step comprising contacting water to be treated with an inorganic oxidising salt containing manganese or iron for a time effective for oxidising a portion of said contaminants;
(b) contacting water treated in oxidation step (a) with at least a chlorine containing agent for disinfection and to generate, in situ and through reaction with chemical compounds produced in oxidation step (a), a coagulant for coagulating oxidised contaminants present in the water;
(c) separating coagulated contaminants from the water; and
(d) in a second vessel subjecting water from step (c) to a further oxidation step for oxidising residual oxidisable contaminants, said oxidation being catalytic oxidation catalysed, in combination, by:(i) manganese or iron depending on the selected inorganic oxidising salt left in solution after oxidation step (a); and
(ii) a solid phase catalyst comprising a granular catalytic material for oxidising residual oxidisable contaminants,

wherein the amount of inorganic oxidising salt added is such that, following separating step (c), sufficient manganese or iron remains in solution to act as a catalyst in step (d); and
wherein step (d) is carried out using a bed reactor, column reactor and/or a filter bed.

US Pat. No. 11,111,164

SULFIDATED NANOSCALE ZEROVALENT IRON AND METHOD OF USE THEREOF


1. A sulfidated nanoscale zerovalent iron (S-nZVIco), wherein said S-nZVIco is a particle comprising a core comprising FeS and Fe0 and a shell comprising FeS, wherein said FeS is bridging said core and said shell.

US Pat. No. 11,111,163

TIME-RELEASE TABLET AND METHODS

Spectrum Brands, Inc., M...


1. A tablet holder for dispensing a chemical formulation comprising:a body portion, wherein the body portion comprises a first side, a second side, and an solid edge from between 90 degrees and 270 degrees along the first side and the second side, at least one of the first side or second side comprises a plurality of apertures, the plurality of apertures sized to control the rate of dispersal of the chemical formulation in a high flow environment and wherein the first side and second side are substantially similar in size and comprise a fixed distance between the first side and the second side in a use and non-use configuration,
wherein the first and second sides are connected via the edge, whereby forming an internal cavity, wherein the edge comprises an opening, wherein the opening of the edge is in communication with and permitting access to the internal cavity, and wherein the internal cavity is sized to allow for a metered dose of the chemical formulation to be placed therein.

US Pat. No. 11,111,162

METHOD AND TREATMENT SYSTEM FOR TREATING MINERAL OR OIL SANDS TAILINGS

KEMIRA OYJ, Helsinki (FI...


1. A method for treating tailings substrate from mining or oil sands separation process, the tailings substrate comprising an aqueous phase with suspended solid particulate material, the method comprising:(i) adding a flocculating agent to the tailings substrate, which flocculating agent comprises a degraded amphoteric polyacrylamide comprising both anionic and cationic units having a process water viscosity reduced by 25-99% compared to a substantially similar polyacrylamide that has not been degraded by a degradation agent, measured at a shear rate 1 s?1 as a 0.4-0.8 weight-% solution of polymer in process water,
(ii) allowing flocs, which comprise solid particulate material, to form, and
(iii) allowing the formed flocs to separate from the aqueous phase.

US Pat. No. 11,111,161

RARE EARTH CLARIFYING AGENT AND METHOD FOR USE IN PRIMARY TREATMENT OF WASTEWATER

Neo Water Treatment, LLC,...


1. A method for treating wastewater, including removing phosphorus while maintaining a ratio of C—P, comprising:dosing wastewater as part of a primary treatment or before the primary treatment with a clarifying agent of chloride salts of Ce and La having from 55.0-75.0% Ce and from 25.0-45.0% La and any balance being chloride salts of other rare earth elements, in an amount to provide a rare earth (RE):phosphorus (P) molar ratio of approximately 0.1:1 RE:P to approximately 0.8:1 RE:P and at a rare earth concentration of 0.01 to 0.5 mmol/L of wastewater,
wherein the dosing provides a ratio of C to P ranging from 150 C:1 P to 25 C:1 P for dosed wastewater and wherein the dosing reduces one or more of orthophosphate (OP), total phosphorous (TP), total organic carbon (TOC), chemical oxygen demand (COD), and biochemical oxygen demand (BOD); and
passing the dosed wastewater to a secondary treatment, wherein the ratio of C to P maintains microorganisms in the secondary treatment.

US Pat. No. 11,111,160

ASYMMETRIC ELECTROCHEMICAL CELL APPARATUS, AND OPERATING METHODS THEREOF

BAR-ILAN UNIVERSITY, Ram...


1. A towel, comprising:(a) at least a first electrode layer covered by a cloth suitable to reduce mechanical abrasion;
(b) at least a second electrode layer;
(c) an electrically insulating layer disposed in between said first electrode layer and said second electrode layer; at least one of said first electrode layer, said electrically insulating layer, and said second electrode layer being adapted to absorb a liquid;
(d) connectors to facilitate connection of said first electrode layer and said second electrode layer to a power supply; and
(e) an electrochemical capacitance ratio (Rec) of said at least a first electrode layer to said at least a second electrode layer of at least 7:1.

US Pat. No. 11,111,159

MEMBRANE FILTER APPARATUS WITH INTERNALLY SUPPORTED FILTER ASSEMBLY

King Abdulaziz University...


1. A membrane filter apparatus comprising:a body chamber comprising an inlet end and a filter end;
a feed inlet disposed on the inlet end of the body chamber;
a feed distribution tube fluidly connected to the feed inlet comprising a distribution inlet end and a distribution outlet end and comprising one or more feed outlet openings through which a feed may pass into the body chamber;
a retentate outlet fluidly connected to the body chamber and located at the inlet end of the body chamber;
a filter assembly comprising:a filter located at the filter end of the body chamber and oriented substantially perpendicular to the feed distribution tube,
a filter support in contact with a portion of the filter; and

a filter assembly gasket located between the body chamber and the filter assembly at the filter end of the body chamber;
a filter cap which interfaces with the filter end of the body chamber and secures the filter assembly to the filter end of the body chamber, wherein the filter cap has a circumferential internal shoulder protruding from an internal wall of the filter cap to form a resting surface to contact and hold the filter assembly;
wherein:
the feed distribution tube passes through a center of the body chamber in a direction substantially parallel to a length of the body chamber and has a feed distribution tube length sufficient to cause the feed to enter the body chamber at a feed start point such that a feed distance measured from the filter assembly to the feed start point that is less than an entrance distance measured from the feed start point to the feed inlet; and
the membrane filter apparatus is configured such that the feed may flow into the feed inlet, through the feed distribution tube, and out through the one or more feed outlet openings such that the feed flows across the filter in a direction substantially parallel to a surface of the filter assembly where the filter is configured to split the feed into a filtrate and a retentate, the filtrate passing through the filter assembly and the retentate flowing through the body chamber in a direction substantially antiparallel to the feed flow through the feed distribution tube and out through the retentate outlet.

US Pat. No. 11,111,158

CONTROL DEVICE OF LIQUID DISPENSER, LIQUID DISPENSER, AND CONTROL SYSTEM OF LIQUID DISPENSER

LG ELECTRONICS INC., Seo...


1. A system comprising:a liquid dispenser including;an ejector unit; and
a flow channel unit having;a liquid ejection valve to selectively allow flow of liquid to the ejector unit without temperature modification;
a cooling unit in series with a cooled liquid ejection valve to selectively allow flow of cooled liquid to the ejector unit; and
a heating unit in series with a flow rate adjusting valve to selectively allow flow of heated liquid to the ejector unit; and


a control device including:a transceiver to:transmit operation information regarding an operation of the liquid dispenser to a server provided separately from the control device, and
receive control information regarding control of the liquid dispenser from the server; and

a controller configured to:generate the operation information,
transmit the generated operation information to the server through the transceiver, and
control an operation of the liquid dispenser based on the control information received from the server,


wherein the controller controls the liquid ejection valve, the cooled liquid ejection valve, the flow rate adjusting valve, the cooling unit, and the heating unit based on the control information to adjust a flow rate and a temperature of the ejected liquid from the ejector unit,
wherein the operation information includes:
history information regarding usage history of the liquid dispenser, operating information of the flow channel unit, and ejection information of the liquid ejected from the liquid dispenser, wherein the operating information relates to operation status of the liquid ejection valve, the cooled liquid ejection valve, the flow rate adjusting valve, the cooling unit and the heating unit,
wherein at least one of the history information or the ejection information includes information indicating respective aggregate amounts of ejected liquid by times within a prescribed period of at least one day, and
wherein the ejected liquid includes at least one of a flow of liquid without temperature modification, a flow of cooled liquid, or a flow of heated liquid.

US Pat. No. 11,111,157

UNITIZED FORMED CONSTRUCTION MATERIALS AND METHODS FOR MAKING SAME

RJSK, LLC, Spokane, WA (...


1. A method for manufacturing unitized formed mineral-based construction materials, comprising:providing starting materials comprising an aggregate, a cementing agent, a sublimation agent and water;
the sublimation agent selected from the group consisting of molybdenum disulfide, tungsten disulfide, vanadium disulfide, copper sulfate, and combinations thereof;
the sublimation agent being provided in an amount of between 25% and 50% by weight of the cementing agent;
mixing the starting materials with one another to achieve a mixture of the starting materials;
placing the mixture of the starting materials into a form;
curing the mixture of starting materials in the form for a period of time selected to allow the mixture of starting materials to become a solidified unit of the mixture of starting materials, the solidified unit of the mixture of starting materials being defined by a minimum dimension of thickness, length, and one of width or diameter;
placing the solidified unit of the mixture of starting materials into a kiln;
heating the kiln containing the solidified unit of the mixture of starting materials to a processing temperature of between 1115° C. and 1350° C. and maintaining the kiln at the processing temperature for a period of time of between 10 minutes and 60 minutes per centimeter of the minimum dimension of the consolidated unit of the mixture of starting materials; and
removing the solidified unit of the mixture of starting materials from the kiln.

US Pat. No. 11,111,155

SYSTEM, PROCESS AND RELATED SINTERED ARTICLE

Corning Incorporated, Co...


1. A process of forming a sintered article, comprising:heating a green portion of a tape of polycrystalline ceramic and/or minerals in organic binder at a binder removal zone to a temperature sufficient to pyrolyze the binder;
horizontally conveying the portion of tape with organic binder removed from the binder removal zone to a sintering zone; and
sintering polycrystalline ceramic and/or minerals of the portion of tape at the sintering zone, wherein the tape simultaneously extends through the removal and sintering zones.

US Pat. No. 11,111,151

LAYERED SILICATE POWDER GRANULES AND METHOD FOR PRODUCING THE SAME

NATIONAL INSTITUTE FOR MA...


1. A layered silicate powder granule comprising flat particles, each particle comprising an evaporation-spray-dried layered silicate and a rheology modifier for modifying a crystal edge face of the layered silicate, and having an opening or recess in its surface center,wherein the layered silicate is at least one selected from the group consisting of smectites, swelling synthetic micas, and vermiculites.

US Pat. No. 11,111,150

FACILE DIRECT FUNCTIONALIZATION OF PRISTINE GRAPHENE NANOPARTICLES

BOARD OF REGENTS, THE UNI...


1. A method for preparing an aminated graphene comprising reacting graphene with urea in a solvent or a solvent-deionized water mixture, and wherein the ratio of the graphene and the urea is in the range of 0.1-4.0 by weight.

US Pat. No. 11,111,149

FLY ASH-CATALYZED METHOD FOR MAKING GRAPHENE

King Abdulaziz University...


1. A fly ash-catalyzed method for making graphene, the method comprising:reacting, at a temperature in a range of from 10 to 50° C., a dispersed mixture, comprising fly ash, a charged N-heteroaromatic compound, and an alcohol solvent selected from the group consisting of ethanol, ethanol, propanol, isopropanol, butanol, and ethylene glycol, with a polymer-supported oxidizing agent to form a second mixture; and
contacting the second mixture at a temperature of 120 to 180° C. with a gas stream comprising at least 0.1 vol. % CH4 and/or at least 10 vol. % H2 to form graphene on the fly ash.

US Pat. No. 11,111,148

GRAPHENE, PREPARATION METHOD THEREOF AND SUPERCAPACITOR ELECTRODE AND SUPERCAPACITOR CONTAINING THE GRAPHENE

INSTITUTE OF ELECTRICAL E...


1. A method for preparing a graphene, comprising the following steps:i) placing a mixture comprising a magnesium powder and a solid oxide powder in a carbon dioxide-containing environment, wherein the pressure of carbon dioxide in the environment is above 0.125 MPa;
ii) heating said mixture to enable the magnesium powder to react with carbon dioxide, thereby obtaining a graphene.

US Pat. No. 11,111,147

CARBON NANOTUBE COMPOSITE STRUCTURE AND METHOD FOR MAKING THE SAME

Tsinghua University, Bei...


1. A carbon nanotube composite structure, comprising:a carbon nanotube network structure comprising a plurality of carbon nanotubes entangled to each other; and
a sulfur, nitrogen-codoped carbon layer coated on outer surfaces of the plurality of carbon nanotubes and intersections of the plurality of carbon nanotubes, and the plurality of carbon nanotubes bonded together at the intersections by the sulfur, nitrogen-codoped carbon layer; the sulfur, nitrogen-codoped carbon layer consists of nitrogen elements (N), sulfur elements (S), and carbon elements (C); an atomic percentage of the carbon elements, the nitrogen elements, and the sulfur elements is C:N:S=95.4%:3.2%:1.4%; and a polyaniline is a dopant source of the carbon elements and the nitrogen elements, and an ammonium persulphate is both an initiator that initiates the polyaniline and a dopant source of the nitrogen element and the sulfur element.

US Pat. No. 11,111,146

CARBON NANOTUBE PRODUCT MANUFACTURING SYSTEM AND METHOD OF MANUFACTURE THEREOF

WOOTZ, LLC, Houston, TX ...


1. A method of manufacturing a carbon nanotube product, the method comprising:blending an unaligned carbon nanotube material comprising carbon nanotube molecules with solid solvent particles;
activating a nanotube solvent by liquefying the solid solvent particles;
producing a nanotube dope solution by mixing the nanotube solvent and the unaligned carbon nanotube material;
forming a carbon nanotube proto-product by extruding the nanotube dope solution, thereby imparting alignment to carbon nanotube molecules of the carbon nanotube proto-product; and
forming an aligned carbon nanotube product by solidifying the carbon nanotube proto-product by:exposing the carbon nanotube proto-product to an infrared radiation source at a wavelength selected in the range of 1 ?m to 130 ?m to reduce absorption of the radiation by the nanotube solvent relative to absorption of the radiation by carbon nanotubes of the carbon nanotube proto-product, and
exposing the carbon nanotube proto-product to a chemical coagulant, wherein the chemical coagulant is a solvent for the nanotube solvent and a non-solvent for the carbon nanotube proto-product.


US Pat. No. 11,111,145

PRECISE MODIFYING METHOD FOR FINE PARTICLE DISPERSION LIQUID

M. TECHNIQUE CO., LTD., ...


1. A method for reforming a fine particle dispersion solution that includes impurities, comprising:removing impurities in the fine particle dispersion solution by carrying out filtration with a filtration membrane, thereby controlling a dispersion property of the fine particle dispersion solution,
wherein the filtration comprises steps A and B below,
A) decreasing the amount of impurities by filtration and transferring from a first stage to a second stage, wherein the amount of the impurities are defined in the first and second stages,
wherein the first stage has a concentration of impurities of 0.02% or more by weight and the second stage has a concentration of impurities of 0.00005% to 0.02% by weight,
B) controlling the dispersion property by controlling a pH of the fine particle dispersion solution using a pH controlling agent in the second stage.

US Pat. No. 11,111,144

OZONE GAS GENERATOR AND METHOD FOR MANUFACTURING OZONE GAS GENERATOR

Sumitomo Precision Produc...


1. A method for manufacturing an ozone gas generator, comprising:a step of forming a first electrode portion that includes a first electrode;
a step of forming a second electrode portion that includes a second electrode; and
a step of disposing the first electrode portion and the second electrode portion in which the first electrode portion and the second electrode portion face each other with an intended discharge gap Da of 300 ?m or less,
a step of providing a dielectric on a surface of the first electrode or the second electrode on sides facing each other in the first electrode portion and the second electrode portion,
a step of forming a member having a height D2 on the dielectric between the first electrode portion and the second electrode portion,
a step of providing a layer having a thickness D3 that includes at least one of a metal or a metal compound on at least a portion of the surface of the first electrode or the second electrode on the sides facing each other, or the dielectric in the first electrode portion and the second electrode portion, whereinthe member is formed and the layer is provided such that the height D2 and the thickness D3 cause an actual discharge gap D1 between the first electrode portion and the second electrode portion to vary by x % from the intended discharge gap Da, wherein, 10

US Pat. No. 11,111,143

CHEMICAL LOOPING SYNGAS PRODUCTION FROM CARBONACEOUS FUELS

OHIO STATE INNOVATION FOU...


1. A system for converting a fuel, the system comprising:a first moving bed reactor comprising a metal oxide particles having a primary component and a secondary component, wherein fuel, CO2 and steam are added to the first moving bed reactor in a co-current flow pattern relative to the metal oxide particles, wherein the first moving bed reactor is configured to reduce at least a portion of the metal oxide particles with the fuel to produce a first reduced metal oxide, and is further configured to produce a first syngas stream comprising H2, CO, CO2 and steam;
a second moving bed reactor, operating in parallel with the first moving bed reactor and comprising metal oxide particles having a primary component and a secondary component, wherein fuel, CO2 and steam are added to the second moving bed reactor in a co-current flow pattern relative to the metal oxide particles, wherein the second moving bed reactor is configured to reduce at least a portion of the metal oxide particles with the fuel to produce a second reduced metal oxide, and is further configured to produce a second syngas stream comprising H2, CO, CO2 and steam;
a separation unit, in communication with the first moving bed reactor and the second moving bed reactor, and configured to remove the CO2 from the first syngas stream and the second syngas stream, wherein the H2/CO ratios of the first and second syngas streams are controlled by recycling substantially all of the CO2 from the separation unit to the first moving bed reactor and the second moving bed reactor; and
a third co-current fluidized bed reactor in communication with the first moving bed reactor and the second moving bed reactor and configured to oxidize the first reduced metal oxide and the second reduced metal oxide with an oxidizing agent to produce oxidized metal oxide particles and recycle the oxidized metal oxide particles to the first moving bed reactor and the second moving bed reactor for subsequent reduction reactions.

US Pat. No. 11,111,142

PROCESSES AND CATALYSTS FOR REFORMING OF IMPURE METHANE-CONTAINING FEEDS

Gas Technology Institute,...


1. A process for producing hydrogen, the process comprising:contacting, under reforming conditions, a reformer feed comprising methane with a reforming catalyst, to provide a reformer product comprising hydrogen and CO produced from reforming of at least a portion of the methane by reaction with H2O present in the reformer feed,
wherein the reforming catalyst comprises, as noble metals, from about 0.5 wt-% to about 2 wt-% Pt and from about 0.5 wt-% to about 2 wt-% Rh on a solid support comprising cerium oxide and less than about 10 wt-% of magnesium oxide, said reforming catalyst comprising less than 0.05% by weight of metals other than Pt and Rh and metals of said solid support, and
wherein the reformer feed comprises CO in a concentration of at least about 0.5 mol-% and ethylene in a concentration of at least about 1 mol-% and has a steam/carbon molar ratio of at least about 2.0,
wherein the reforming conditions include a temperature from about 649° C. (1200° F.) to about 816° C. (1500° F.), a gauge pressure from about 0 kPa to about 517 kPa (75 psig), and a weight hourly space velocity (WHSV) from about 0.1 hr?1 to about 4.0 hr?1, and
wherein a conversion of said methane is at least about 80%.

US Pat. No. 11,111,141

STORING ACTIVATED ALUMINUM

LTAG SYSTEMS LLC, Bow, N...


1. An Apparatus for hydrogen formation, the apparatus comprising:a container defining a reservoir, the container flexible along the reservoir, the container forming a gas-tight seal between the reservoir and an atmosphere outside of the container;
at least one object including aluminum in an activated form, the at least one object disposed in an inert environment in the reservoir, and the activated form of the aluminum reactable to produce hydrogen in the reservoir upon exposure to water;
a first conduit having a first longitudinal dimension fixed to the container along the reservoir; and
a second conduit having a second longitudinal dimension fixed to the container along the reservoir and substantially parallel to the first longitudinal dimension of the first conduit along the reservoir, the first conduit and the second conduit each in fluid communication with the reservoir, and the container foldable along the first longitudinal dimension of the first conduit and along the second longitudinal dimension of the second conduit.

US Pat. No. 11,111,140

APPARATUS FOR GENERATING HYDROGEN

IHOD LIMITED, Chichester...


1. An apparatus for generating hydrogen; the apparatus comprising:(a) a reactor vessel;
(b) first and second reactant containers linked to the reactor vessel, the first and second reactant containers containing, respectively, first and second reactants which, when mixed, react to form hydrogen gas;
(c) one or more peristaltic pumps for pumping the first and second reactants from the reactant containers to the reactor vessel so that the reactants mix and react to form hydrogen gas, the peristaltic pumps being selected to provide a maximum pumping pressure in the range from 0.1 bar to 10 bar;
(d) a buffer tank for receiving hydrogen gas from the reactor vessel;
(e) a pressure sensor for measuring pressure of hydrogen gas within the apparatus; and
(f) electronic control means for controlling operation of the apparatus, the electronic control means being in communication with the one or more pumps and the pressure sensor and being programmed to control the flow of reactants to the reactor vessel so as to maintain the pressure of hydrogen gas within the apparatus at a value of no more than 10 bar.

US Pat. No. 11,111,139

PLANAR CAVITY MEMS AND RELATED STRUCTURES, METHODS OF MANUFACTURE AND DESIGN STRUCTURES

INTERNATIONAL BUSINESS MA...


1. A Micro-Electro-Mechanical System (MEMS) structure comprising:at least one oxide peg; and
a beam comprising at least one insulator layer and a metal layer over the at least one oxide peg.

US Pat. No. 11,111,138

PLANAR CAVITY MEMS AND RELATED STRUCTURES, METHODS OF MANUFACTURE AND DESIGN STRUCTURES

INTERNATIONAL BUSINESS MA...


1. A structure, comprising:at least one fixed plate;
an insulator layer covering the at least one fixed plate; and
a TiN/TiAl3 layer between the at least one fixed plate and the insulator layer,
wherein the insulator layer has a tapered profile.

US Pat. No. 11,111,137

METHOD FOR MANUFACTURING A MICROMECHANICAL SENSOR

Robert Bosch GmbH, Stutt...


1. A method for manufacturing a micromechanical sensor, comprising:providing a MEMS wafer that includes a MEMS substrate, a plurality of etching trenches being formed in the MEMS substrate in a diaphragm area opposite a diaphragm, the diaphragm being formed in a first silicon layer situated at a defined distance from the MEMS substrate;
providing a cap wafer;
bonding the MEMS wafer to the cap wafer; and
forming a media access point to the diaphragm area by grinding the MEMS substrate;

wherein:(I) (1) the etching trenches are formed above the diaphragm and the cap wafer is arranged below the diaphragm, so that the diaphragm is arranged between the etching trenches and the cap wafer, and/or (2) the formation of the media access point is performed after the bonding of the MEMS wafer to the cap wafer; and
(II) (1) during formation of the etching trenches in the MEMS substrate, an additional etching trench is formed that is laterally spaced apart in a defined manner from the plurality of etching trenches, and that has a narrower design, in a defined manner, than each of the etching trenches for the media access point, and (2) one or both of the following:a) the additional etching trench encircles the plurality of etching trenches; and
b) the additional etching trench is left unfilled, extends from a first of its ends to a second of its ends in a direction in which the plurality of etching trenches extend from the media access point towards the diaphragm, and is closed at the first of its ends and open at the second of its ends while the plurality of etching trenches open to the diaphragm and have the media access point.


US Pat. No. 11,111,136

USE OF A REACTIVE, OR REDUCING GAS AS A METHOD TO INCREASE CONTACT LIFETIME IN MICRO CONTACT MEMS SWITCH DEVICES

International Business Ma...


1. A process for reducing contaminants in a MEMS device, comprising:placing a reactive gas within a chamber containing the MEMS device, the MEMS device including an electro mechanical element having operating surfaces positioned within the chamber, the reactive gas being selected to react with contaminants that are present or formed on the operating surfaces of the MEMS device and comprising a non-explosive azane selected from a homologous series of inorganic compounds with the general chemical formula NnHn+2, where n=1˜7 or combinations thereof;
introducing an inert gas within the chamber; and
sealing the chamber,
wherein the reactive gas is placed within the chamber before sealing the chamber, and the reactive gas remains within the chamber after sealing the chamber,
wherein the inert gas is introduced in a mixture with the reactive gas and remains in the chamber with the reactive gas after sealing the chamber.

US Pat. No. 11,111,135

METHODS AND DEVICES FOR MICROELECTROMECHANICAL PRESSURE SENSORS

MY01 IP Holdings Inc., M...


1. A method for post-fabrication of a MEMS device, the method comprising:providing the MEMS device comprising (i) a handling layer, (ii) a top layer, and (iii) a device layer located between the handling layer and the top layer, wherein the handling layer comprises a first trench on a top face of the handling layer adjacent to the device layer, wherein the top layer comprises a second trench on a bottom face of the top layer adjacent to the device layer, the second trench facing the first trench, wherein a first portion of the top layer is electrically insulated from a second portion of the top layer, wherein the first portion of the top layer extends to the second trench, wherein the device layer comprises a section of silicon positioned between the first trench and the second trench;
etching a back face of the handling layer until reaching the first trench, thereby forming an opening extending through the handling layer; and
etching the section of silicon of the device layer through the opening in the handling layer, thereby thinning the section of silicon of the device layer to form a flexible membrane that is (i) positioned between the opening and the second trench and (ii) capacitively coupled with the first portion of the top layer.