US Pat. No. 10,190,267

ARTIFICIAL TURF FOR LANDSCAPE AND SPORTS

BFS EUROPE NV, Kruishout...

1. An artificial turf comprising:a mechanically bounded layer of fibers consisting of non-woven matting comprising one or more natural and/or synthetic fibers, and
pile yarn inserted through the mechanically bounded layer of fibers, the pile yarn being anchored to the mechanically bounded layer of fibers,
wherein the mechanically bounded layer of fibers has a density that decreases from the bottom to the top of the mechanically bounded layer of fibers, and
wherein the mechanically bounded layer of fibers is on top of a backing, and the mechanically bounded layer of fibers includes a lower layer an an upper layer, the lower layer being positioned at the bottom of the mechanically bounded layer of fibers and the upper layer being positioned on top of the lower layer, and the upper layer having a higher fiber coarseness than the lower layer.

US Pat. No. 10,190,266

REINFORCED RUBBER GROUND COVER MAT

Champagne Edition, Inc., ...

1. A ground cover mat comprising:(a) a slab made of a slab material comprising rubber, the slab defining a horizontally extending lower major surface of the ground cover mat and a horizontally extending upper major surface of the ground cover mat; and
(b) a core assembly encased by the slab and disposed vertically between the lower major surface and the upper major surface of the ground cover mat, the core comprising:
(i) a plurality of boards extending horizontally along a majority of the length of the slab and disposed in horizontally spaced apart side-by-side relation with each other; and
(ii) a rebar mesh disposed on top of and in contact with the plurality of boards, the rebar mesh comprising a first plurality of horizontally extending rebars disposed in horizontally spaced apart side-by-side relation with each other, and a second plurality of horizontally extending rebars disposed in horizontally spaced apart side-by-side relation with each other, wherein the rebars of the second plurality of rebars are oriented transversely to and in contact with the rebars of the first plurality of rebars;
wherein the first plurality of rebars are in contact with the boards and disposed vertically between the boards and the second plurality of rebars, or the rebars of the second plurality of rebars are in contact with the boards and disposed vertically between the boards and the first plurality of rebars: and
wherein the rubber of the slab material fills spaces between the rebars of the rebar mesh and the boards.

US Pat. No. 10,190,265

COMPOSITIONS AND METHODS FOR PELLETIZED RECYCLED ASPHALT SHINGLES

1. An asphalt pavement comprising:a first stage mix comprising:
recycled asphalt shingles material; and
a softening agent; wherein the softening agent is selected from the group consisting of biofuels, bio-oils, and combinations thereof;
a second stage mix comprising:
virgin recycled asphalt shingles material;
hydrated lime; and,
a water-resistant modified lignin sulfate binder; and
a performance grade neat asphalt,wherein the performance grade neat asphalt is combined with a combination of the second stage mix with the first stage mix.

US Pat. No. 10,190,264

MULTI-FUNCTIONAL RAILWAY FASTENING COMPONENT ADJUSTMENT SYSTEM

MOW Equipment Solutions, ...

1. A multi-functional railway fastening component adjustment system comprising:a railway component adjuster comprising:
a tool bracket;
one or more adjustment tools pivotally coupled with the tool bracket;
one or more tool actuators coupled with the one or more adjustment tools and the tool bracket, the one or more tool actuators adapted to cause pivotal movement of the one or more adjustment tools with respect to the tool bracket; and
a main bracket comprising one or more attachment components to couple the railway component adjuster to a frame structure;
the railway component adjuster configured to selectively engage each railway fastening component of a plurality of railway fastening components from a plurality of different addressing positions of the one or more adjustment tools at least in part by pivoting to a selected addressing position of the plurality of different addressing positions, wherein:
the plurality of railway fastening components comprises a railway anchor and a railway tie plate;
the railway component adjuster is adapted to hold the one or more adjustment tools in the selected addressing position to make a component adjustment to the railway fastening component with the one or more adjustment tools; and
the component adjustment comprises movement of the railway fastening component along a rail of a railway.

US Pat. No. 10,190,263

SOFT THROUGH AIR DRIED TISSUE

First Quality Tissue, LLC...

1. A system for making tissue, comprising:a mixing section that provides a pulp mix, the mixing section including a wet-end adding section that delivers a wet-end additive to the pulp mix at a first point in a process for manufacturing tissue;
a forming section that forms after the first point in the process a wet web from the pulp mix provided by the mixing section;
a drying section that dries the wet web into a basesheet of tissue;
a winding section that winds the basesheet tissue onto a roll; and
a sensor that detects a break in the basesheet tissue;
wherein operation of the wet-end adding section is controlled by the sensor so that delivery of the wet-end additive to the pulp mix is prevented at the first point in response to the sensor detecting a break in the basesheet tissue.

US Pat. No. 10,190,262

OPTICAL BRIGHTENING AGENT COMPOSITION

TEH FONG MIN INTERNATIONA...

1. An optical brightening agent composition for optical brightening of surfaces of paper or cardboards consisting of: water, a compound as shown in chemical formula (1), and sodium methylene dinaphthalene sulfonates:
wherein the sodium methylene dinaphthalene sulfonates are chemical compounds, as shown in chemical formula (2), chemical formula (3) or chemical formula (4):

R1 is a functional group, as shown in chemical formula (6), or chemical formula (7):

and R2 is a functional group, as shown in chemical formula (8), chemical formula (9), or chemical formula (10):

US Pat. No. 10,190,260

FLUFF PULP AND HIGH SAP LOADED CORE

INTERNATIONAL PAPER COMPA...

1. A fluff pulp composition, comprising:softwood fibers;
8 to 23% by weight of hardwood fibers; and
one or more superabsorbent polymer (SAP),
wherein the fluff pulp composition has a SAP retention value greater than 75%.

US Pat. No. 10,190,259

PNEUMATIC DUST HOOD WITH PLUG PREVENTER

Brunn Air Systems, Inc., ...

1. A pneumatic hood, comprising:a hood body having an outlet;
an elongate, open inlet provided in one face of the hood body and extending substantially the entirety of a width of the hood body, the inlet being much wider than it is high;
an inlet flap hingedly connected to and contiguous with the hood body to define a central portion of the inlet, the inlet flap extending over only a portion of the width of the inlet;
one or more actuators coupled to the inlet flap to move the inlet flap so as to selectively and temporarily increase the size of the central portion of the inlet.

US Pat. No. 10,190,257

WIRE CABLE AND METHOD AND DEVICE FOR PRODUCTION OF SAID WIRE CABLE

CASAR DRAHTSEILWERK SAAR ...

1. A method for producing a wire cable, comprising the steps of: precompacting a core cable and afterwards compacting the core cable by hammering to smooth an outer surface of the core cable and increase flexibility and bending strength of the wire cable; applying a plastic layer to the core cable; softening the plastic layer; subsequently twisting multiwire strands onto the core cable covered by the softened plastic layer and pressing the multiwire strands into the softened plastic layer; and hammering the wire cable after the multiwire strands are twisted on the core cable and pressed into the plastic layer.

US Pat. No. 10,190,256

DEVICE AND METHOD FOR PRODUCING A STRAND OR A CABLE

CASAR DRAHTSEILWERK SAAR ...

1. A device for producing a strand or cable, the device comprising: a rotatable feed arrangement for feeding cords to a twisting point, at which the cords are to be twisted around a core strand of the strand or a core cable for forming the strand or the cable, and an installation for heating the core strand or the core cable, wherein the heating installation is rotatable together with the feed arrangement, the heating installation being arranged to apply heat to the core strand or the core cable in an area in which the cords are guided from the rotatable feed arrangement to the twisting point, wherein the heating installation is arranged in free spaces between the cords leading to the twisting point so as to focus heat on the core strand or the core cable, so that the core strand or the core cable is heated more strongly than the cords and strong heating of the cords is avoided.

US Pat. No. 10,190,254

SKIN MATERIAL

Seiren Co., Ltd., Fukui ...

1. A skin material comprising a closed cellular heat-insulating layer and a coloring layer which are sequentially stacked on a fibrous substrate, wherein the skin material has unevennesses on a front face, the closed cellular heat-insulating layer has a softening temperature of 110° C. to 250° C., and a contact cool feeling (Qmax) of the front face of the skin material is 0.30 W/cm2 or less both before and after a heat treatment for 2400 hours at 70° C., and wherein the closed cells of the closed cellular heat-insulating layer consist of closed cells obtained by mixing a resin serving as a matrix with hollow particles forming the closed cells of the cellular heat-insulating layer, the hollow particles consist of expanded polymeric microcapsules, and each of closed cells consists of a respective one of the expanded polymeric microcapsules, and the matrix has a softening temperature of 110° C. to 250° C., and a glass transition point of ?100° C. to 50° C., and a resin that forms outer shells of the hollow particles has a softening temperature of 110° C. to 250° C., and a glass transition point of 50° C. to 150° C.

US Pat. No. 10,190,253

NANOPARTICLE TREATED FABRICS, FIBERS, FILAMENTS, AND YARNS AND RELATED METHODS

ATTOSTAT, INC, Salt Lake...

1. A nanoparticle treated fibrous article, comprising:a fibrous article selected from a fabric, fiber, filament, or yarn; and
a plurality of exposed, nonionic, spherical-shaped metal nanoparticles free of angled edges or external bond angles,
the metal nanoparticles being formed through a laser-ablation process,
at least a portion of the metal nanoparticles being silver nanoparticles that provide effective microbial control without significant release of toxic silver ions, and
the metal nanoparticles being non-covalently affixed to the fibrous article through Van der Waals forces, without electrostatic forces, without being embedded within a fiber, filament, or yarn of the fibrous article, and without being encapsulated within a polymer or adhesive coating,
wherein the metal nanoparticles remain affixed to the fibrous article when exposed to one or more of water, soap, a surfactant, or a solvent.

US Pat. No. 10,190,252

DRY-CLEANING SOLVENT FILTER APPARATUS FOR ENVIRONMENTALLY-FRIENDLY REUSE AND METHOD OF OPERATING THEREOF

1. A dry-cleaning solvent filter apparatus configured to deodorize, detoxify, and reclaim a contaminated dry-cleaning solvent, the dry-cleaning solvent filter apparatus comprising:an intake pipe connecting a dry-cleaning machine and a dry-cleaning solvent reserve tank of the dry-cleaning solvent filter apparatus;
the dry-cleaning solvent reserve tank operatively connected to the dry-cleaning machine via the intake pipe, wherein the intake pipe brings a contaminated dry-cleaning solvent from the dry-cleaning machine into the dry-cleaning solvent reserve tank prior to filtration;
a multi-level filtration container comprising a first-stage filter chamber with a first set of drilled micro holes on a first solid surface, a second-stage filter chamber with a second set of drilled micro holes on a second solid surface, and a gap separating the first-stage filter chamber and the second-stage filter chamber, wherein the first set and the second set of drilled micro holes hold up a multi-metallic and multi-chemical clay filtration agent from escaping downward while allowing a downward movement of a cleaned solvent;
the multi-metallic and multi-chemical clay filtration agent removably deposited on top of the first set of drilled micro holes on the first solid surface in the first-stage filter chamber, and also removably deposited on top of the second set of drilled micro holes on the second solid surface in the second-stage filter chamber, wherein the multi-metallic and multi-chemical clay filtration agent deposited in each chamber is physically separated by the gap between the first-stage filter chamber and the second-stage filter chamber;
a reserve tank-to-filtration container pipe that connects the dry-cleaning solvent reserve tank and the multi-level filtration container to mobilize the contaminated dry-cleaning solvent from the dry-cleaning reserve tank to a top portion of the multi-level filtration container; and
an outtake pipe connecting a treated solvent outlet of the multi-level filtration container to a fresh dry-cleaning solvent reserve tank inside the dry-cleaning machine, wherein the outtake pipe carries a deodorized and decontaminated dry-cleaning solvent that has been treated by the multi-level filtration container.

US Pat. No. 10,190,251

LAUNDRY TREATING APPARATUS HAVING A DETERGENT SUPPLY MODULE

LG ELECTRONICS INC., Seo...

1. A front-loading laundry treating apparatus, comprising:a cabinet provided with a laundry introduction port for introduction of laundry;
a tub arranged in the cabinet to provide a space to store washing water, wherein the tub communicates with the introduction port;
a detergent supply module positioned under the laundry introduction port and adjacent to a periphery of the laundry introduction port to supply a detergent to the tub, wherein the detergent supply module is detachably provided to the cabinet; and
a water supply channel arranged to connect a water supply source to the tub, wherein the detergent supply module is provided in a space defined between the tub and a door configured to open the introduction port.

US Pat. No. 10,190,250

DRIVING APPARATUS FOR WASHING MACHINE

NEW MOTECH CO., LTD., Gw...

1. A driving apparatus for a washing machine, comprising:a clutch housing comprising a washing shaft and a dewatering shaft penetrating the inside;
an annular clutch holder installed in the lower part of the clutch housing;
a clutch lever hinge-coupled to the clutch holder, including an upper rotation part and a coupler receiving part;
a driving lever having a lever arm interlocking with the upper rotation part of the clutch lever;
a clutch coupler laid on the upper part of the coupler receiving part performing up and down spline movement by the coupler receiving part;
a motor assembly coupled to the lower part of the clutch holder, comprising a stator assembly and a rotor assembly; and
a waterproof cover covering the upper part of the motor assembly;
wherein the waterproof cover comprises a cavity formed in the inside, and at least one coupling protrusion formed being protruded towards the inside of the cavity,
wherein at least one waterproof cover coupling hole is formed in the clutch holder so that the waterproof cover is coupled to the lower part of the clutch housing by coupling the coupling protrusion with the waterproof cover coupling hole.

US Pat. No. 10,190,249

APPLIANCE CONTROL UNIT WITH ARRANGED CONTROL SWITCHES

Whirlpool Corporation, B...

1. A household appliance for treating at least one item according to a cycle of operation and configured to receive power from a power source having an AC voltage line and a neutral line, the household appliance comprising:a treating chamber for receiving the item; and
a central control unit to control independent electrical loads associated with the cycle of operation;
wherein the central control unit of the household appliance comprises a first plurality of parallel controlled master switches in the AC voltage line and a second plurality of parallel controlled slave switches in the neutral line thereby defining a number of independent loads equal to the number of the first plurality multiplied by the number of the second plurality.

US Pat. No. 10,190,248

SYSTEM FOR MONITORING RESTORATION QUALITY TO A THIRD PARTY CERTIFIED STANDARD OF SOFT OBJECTS BEING WASHED REMOTELY

1. A remote monitoring system comprising:a volume of consumables independently pre-certified to clean and restore an item to a pre-determined certification standard of cleanliness;
at least one washing machine for washing wash items;
at least one container configured to hold the volume of the consumables, the at least one container being removably couplable to the at least one washing machine and configured to provide a portion of the volume of the consumables to the washing machine during a washing cycle;
a wash processor comprising a tracking mechanism configured to track wash environment data, wherein the wash processor is adapted to communicate over the internet;
at least one container identifier associated with the at least one container for identifying a characteristic of the consumables;
an administrator processor, remote from said at least one washing machine, adapted to communicate over the internet with each said wash processor and to receive data from each said wash processor on a repeating, short-time interval, the administrator processor configured to, for each of the at least one washing machine, track the portion of the volume of the consumables used by the washing machine, track the level of the volume of the consumables in the at least one container, and when the stored volume of the consumables decreases below a pre-determined refill threshold in the at least one container automatically begin resupply procedures to provide additional consumables to the system.

US Pat. No. 10,190,246

TUFTING MACHINE DRIVE SYSTEM

Card-Monroe Corp., Chatt...

1. A tufting machine for forming tufted articles, comprising:backing feed rolls feeding a backing material through the tufting machine;
at least one needle bar having a plurality of needles mounted therealong, each of the needles carrying a yarn for forming tufts of yarns in the backing material as the needles are reciprocated into and out of the backing material;
a first directional drive component including a series of push rods for driving the at least one needle bar in a first direction along its reciprocating motion, and a series of needle bar support brackets coupled to the push rods, the needle bar support brackets including linear motion bearing guides each having a series of linear motion bearings arranged therealong and configured to slidably receive a guide track mounted to the at least one needle bar as the at least one needle bar is moved in a second direction and the at least one needle bar is reciprocated in the first direction; and
a second directional drive component including at least one shift mechanism connected to the at least one needle bar by at least one connecting arm assembly, the at least one connecting arm assembly comprising a guide arm mounted to the at least one needle bar and a linear bearing assembly bracket having linear motion bearings therealong and defining a channel through which the guide arm is received during the reciprocating movement of the at least one needle bar in its first direction while the at least one needle bar is moved in its second direction substantially transverse to the first direction by the at least one shift mechanism.

US Pat. No. 10,190,245

CATHEDRAL WINDOW QUILT KIT

1. A cathedral window quilt kit comprising:a transparent template having a top side, a bottom side, a north side, a south side, an east side, a west side, a northeast corner, a northwest corner, a southwest corner, a southeast corner, a center, an L-shaped ruler, a plurality of cut lines, a plurality of first holes, and a plurality of second holes, wherein a circumference of each of the plurality of second holes is less than a circumference of each of the plurality of first holes;
wherein the L-shaped ruler has a plurality of demarcations disposed within the top side of the transparent template;
wherein the plurality of cut lines is disposed from the top side of the transparent template to the bottom side thereof, and each of the plurality of cut lines is a color;
wherein a first four of the plurality of cut lines are disposed in a first square shape proximal the northwest corner of the transparent template, wherein the first four cut lines are configured to make a quilt window frame;
wherein a second four of the plurality of cut lines are disposed in a second square shape proximal the southwest corner of the transparent template, wherein the second square shape is smaller than the first square shape, wherein the second four cut lines are configured to make a quilt window pane;
wherein the remainder of the plurality of cut lines is disposed proximal the southeast corner of the transparent template, wherein the remainder of the plurality of cut lines is configured to make a quilt trim;
wherein the plurality of first holes is disposed from the top side of the transparent template to the bottom side thereof, and the plurality of first holes is disposed in a square grid pattern, wherein the plurality of first holes is configured to mark a fabric to ensure precision of the quilt window frame;
wherein the plurality of second holes is disposed from the top side of the transparent template to the bottom side thereof proximal the center of the transparent template, and the plurality of second holes is disposed in a first line from the southwest corner of the transparent template to the northeast corner thereof or a second line from the southeast corner of the transparent template to the northwest corner thereof, wherein the plurality of second holes is configured to mark a fabric to create a miniature quilt window for a scrapbook or a piece of jewelry;
a plurality of silk pins;
a plurality of T-pins;
a cut-and-press pad;
a rotary cutter;
a snap wrist ruler;
a friction marker; and
a case with a plurality of indentations, wherein one of the transparent template, the plurality of silk pins, the plurality of T-pins, the cut-and-press pad, the rotary cutter, the snap wrist ruler, and the friction marker is selectively receivable within one of the plurality of indentations.

US Pat. No. 10,190,241

LINKING DEVICE AND MACHINE COMPRISING SAID DEVICE

1. A linking device comprising:a first bowed needle mounted on a first shaft;
a second bowed needle mounted on a second shaft; wherein the first shaft and the second shaft are mutually inclined to each other and are controlled in order to pivot reciprocatingly around a pivoting axis of the first shaft and a pivoting axis of the second shaft, respectively;wherein: the first shaft is rigidly coupled to a first pin pivoting therewith; the second shaft is rigidly coupled to a second pin pivoting therewith; and a slider is slidingly mounted on the first pin and on the second pin.

US Pat. No. 10,190,240

WOVEN PREFORM, COMPOSITE, AND METHOD OF MAKING THEREOF

Albany Engineered Composi...

1. A method of forming a three dimensional woven preform, the method comprising the steps of:weaving a warp steered fabric having weft fibers and warp fibers that is curved in an X-Y plane; and
laying one or more layers of said warp steered fabric to form a predetermined shape,
wherein a first portion of the warp steered fabric including warp fibers which are elongatable fibers or discontinuous tows: a second portion of the warp steered fabric including warp fibers which are not stretch broken carbon fibers, and a third portion of the warp steered fabric including fibers which are elongatable fibers or discontinuous tows;
forming the steered fabric to cause the elongatable fibers or discontinuous tows in the first portion to elongate in a circumferential direction of the X-Y plane to form a joggle of a body portion of the perform, and causing the third portion of the steered fabric to curve and form an upstanding leg in Z direction, the body portion of the preform comprising the first portion and the second portion of the warp steered fabric.

US Pat. No. 10,190,235

WAFER SUPPORTING STRUCTURE AND METHOD FOR FORMING THE SAME

Taiwan Semiconductor Manu...

1. A device comprising:a wafer boat comprising at least a first column, a second column, a third column, and a fourth column fixed to a top plate and a bottom plate of the wafer boat, wherein a first lateral distance between the first column and second column, a second lateral distance between the second column and the third column, and a third lateral distance between the third column and the fourth column are equal; and
a supporting structure configured to support a wafer in the wafer boat, wherein:
the supporting structure is formed of silicon having an oxygen content level equal to or less than 1 parts-per-million-atomic (ppma) and the supporting structure is of a diameter greater than 300 mm, and wherein the supporting structure comprises a first portion having a first inner radius, a second portion having a second inner radius and a third portion having a third inner radius, and wherein:
the first portion is separated from the third portion by a first gap of the supporting structure,
the second portion joins the first portion to the third portion opposite the first gap,
the first inner radius is equal to the third inner radius, and
the second inner radius is greater than the first inner radius; and
wherein the wafer is of a wafer diameter equal to or greater than 300 mm, wherein the wafer is in direct contact with the supporting structure.

US Pat. No. 10,190,234

CONTINUOUS SYSTEM FOR FABRICATING MULTILAYER HETEROSTRUCTURES VIA HYDRIDE VAPOR PHASE EPITAXY

Wisconsin Alumni Research...

1. A system for fabricating multilayer heterostructures via hydride vapor phase epitaxy (HVPE), the system comprising:a deposition assembly comprising:
a plurality of deposition chambers and a plurality of separation chambers mounted together, each separation chamber having two opposing ends, each end mounted to a deposition chamber of the plurality of deposition chambers and in fluid communication with the deposition chamber via a fluid pathway, wherein each deposition chamber of the plurality of deposition chambers defines a deposition zone having a height hd, each separation chamber defines a separation zone having a height hs and a length ls, and each fluid pathway has a height hfp, wherein hfp, hs and ls are selected to provide a predetermined interfacial transition region value between different material layers of a multilayer heterostructure; and
a moveable belt configured to continuously convey a substrate mounted thereon through the plurality of deposition chambers and the plurality of separation chambers; and
a gas delivery assembly configured to deliver reactant gas mixtures to the deposition assembly for deposition on the substrate via HVPE.

US Pat. No. 10,190,233

METHOD AND DEVICE FOR PRODUCING A GROUP 13 ELEMENT NITRIDE CRYSTAL USING A SHIELDING OBJECT

NGK INSULATORS, LTD., Ai...

1. A method of producing a crystal of a nitride of a group 13 element, said method comprising:placing a group 13 element source, a flux comprising at least one of an alkali metal and an alkaline earth metal, and an additive being liquid at an ambient temperature in a crystal growing vessel; and
heating and pressurizing said crystal growing vessel under a nitrogen atom-containing gas atmosphere to form a melt containing said group 13 element source, said flux and said additive,
wherein evaporation of said additive is prevented by a shielding object consisting essentially of said flux until said flux is melted and then said crystal of said nitride of said group 13 element is grown in said melt,
wherein said additive is hydrocarbon or a dopant of said crystal;
wherein said additive is contained in a container; and
wherein the whole of said container is composed of said shielding object and is dissolved into said melt, or wherein said container comprises a main body having a storage part storing said additive and a lid composed of said shielding object, and said lid is dissolved into said melt and said main body is left in said melt.

US Pat. No. 10,190,232

APPARATUSES AND METHODS FOR MAINTAINING PH IN NICKEL ELECTROPLATING BATHS

Lam Research Corporation,...

1. An electroplating system for electroplating nickel onto a semiconductor substrate comprising:an electroplating cell configured to hold an electrolyte solution during electroplating, the electroplating cell comprising:
(a) a cathode chamber;
(b) an anode chamber configured to hold a soluble nickel anode during electroplating;
(c) the soluble nickel anode positioned in the anode chamber, wherein the soluble nickel anode is configured to generate nickel ions during electroplating;
(d) a porous separator between the anode chamber and the cathode chamber permitting passage of ionic current during electroplating, but inhibiting the passage of electrolyte solution; and
(e) a semiconductor substrate holder for holding the semiconductor substrate during electroplating; and
an oxygen removal device arranged to reduce oxygen concentration in the electrolyte solution as it is flowed to the anode chamber during electroplating and during idle times when the system is not electroplating; and
a pH meter configured to measure the pH of the electrolyte solution and logic for operating the oxygen removal device in response to values output by the pH meter.

US Pat. No. 10,190,231

NI-PLATED STEEL SHEET, AND METHOD FOR PRODUCING NI-PLATED STEEL SHEET

1. A Ni-plated steel sheet, comprising:a steel sheet;
a first Ni-plated layer which is formed at least on a one-sided surface of the steel sheet and contains Ni; and
a second Ni-plated layer which is formed on the first Ni-plated layer and contains Ni, wherein an average central-line roughness Ra at an interface between the first Ni-plated layer and the second Ni-plated layer is less than 0.1 ?m,
an average central-line roughness Ra of a surface of the second Ni-plated layer is 0.1 ?m to 100 ?m, and
a coating amount of Ni in an entirety of the first Ni-plated layer and the second Ni-plated layer is 20 mg/m2 to 2500 mg/m2 per one-sided surface in terms of metal Ni.

US Pat. No. 10,190,230

CROSS FLOW MANIFOLD FOR ELECTROPLATING APPARATUS

Novellus Systems, Inc., ...

1. A method for electroplating a substrate, the method comprising:(a) receiving the substrate in a substrate holder, the substrate being substantially planar, wherein a plating face of the substrate is exposed, and wherein the substrate holder is configured to hold the substrate such that the plating face of the substrate is separated from an anode during electroplating;
(b) immersing the substrate in electrolyte, wherein a gap of about 10 mm or less is formed between the plating face of the substrate and an upper surface of an ionically resistive element, wherein the ionically resistive element is at least coextensive with the plating face of the substrate, and wherein the ionically resistive element is adapted to provide ionic transport through the ionically resistive element during electroplating;
(c) flowing electrolyte in contact with the substrate in the substrate holder from a side inlet, into the gap, and out a side outlet, wherein the side inlet and side outlet are positioned proximate azimuthally opposed perimeter locations on the plating face of the substrate, and wherein the side inlet and side outlet are designed or configured to generate cross-flowing electrolyte in the gap during electroplating;
(d) rotating the substrate holder; and
(e) electroplating material onto the plating face of the substrate while flowing the electrolyte as in (c).

US Pat. No. 10,190,229

INTERIOR PLATING AND AUTOMATED SURFACE-DEPOSITION SYSTEM

OCEANIT LABORATORIES, INC...

1. A system, comprising:a plurality of modular segments flexibly attached to one another; and
sources of electrical power and plating and coating solutions;
wherein the plurality of modular segments comprise:
a drive stage configured to push the plurality of modular segments along a surface;
a plating stage configured to apply the plating solution to the surface; and
a surface treatment application stage configured to apply the coating solution to the surface, which will cure to form a final coating on the surface that is resistant to corrosion and buildup.

US Pat. No. 10,190,228

COPPER ELECTROPLATING BATHS AND ELECTROPLATING METHODS CAPABLE OF ELECTROPLATING MEGASIZED PHOTORESIST DEFINED FEATURES

Rohm and Haas Electronic ...

1. A method comprising:a) providing a substrate comprising a layer of photoresist, wherein the layer of photoresist comprises a plurality of apertures;
b) providing a copper electroplating bath comprising one or more sources of copper ions, one or more electrolytes, wherein the electrolytes comprise an acid or a mixture of acids and, optionally, a source of halide ions; one or more accelerators; one or more suppressors; one or more first reaction products consisting of a bisepoxide and an aromatic amino acid compound having a formula:

wherein R1 and R2 are independently chosen from hydrogen, —NH2 and —OH; E is nitrogen or CR3; G is nitrogen or CR4 and Z is nitrogen or CR5 with the proviso that only one of E, G and Z is a nitrogen at the same time and R3, R4 and R5 are independently chosen from hydrogen, —NH2 and —OH with the proviso that at least one of R1, R2, R3, R4 and R5 is —NH2; and one or more second reaction products consisting of an imidazole with an epoxide;
c) immersing the substrate comprising the layer of photoresist with the plurality of apertures in the copper electroplating bath; and
d) electroplating a plurality of copper photoresist defined megapillars in the plurality of apertures, wherein the megapillars have aspect ratios of 3:1 to 1:1, and the plurality of copper photoresist defined megapillars comprise an average % TIR of ?5% to +15%.

US Pat. No. 10,190,227

ARTICLES COMPRISING AN ELECTRODEPOSITED ALUMINUM ALLOYS

Xtalic Corporation, Marl...

1. An article comprising:an electrodeposited aluminum manganese alloy, wherein the electrodeposited aluminum manganese alloy comprises an average grain size less than approximately 1 micrometer, wherein at least a portion of the electrodeposited aluminum manganese alloy has a thickness that is greater than approximately 40 micrometers, wherein a ductility of the entire portion of the electrodeposited aluminum manganese alloy is between approximately 2% and 40%, and wherein the electrodeposited aluminum manganese alloy comprises between approximately 1 atomic percent manganese to approximately 20 atomic percent manganese.

US Pat. No. 10,190,225

ELECTRODEPOSITED COPPER FOIL WITH LOW REPULSIVE FORCE

CHANG CHUN PETROCHEMICAL ...

1. A method for manufacturing electrodeposited copper foil comprising:(a) preparing a copper sulfate electrolyte solution with a chlorine ion concentration of 20 ppm or less;
(b) performing an electrochemical reaction on the copper sulfate electrolyte solution using a current density of about 80 A/dm2 or less to yield a bare copper foil; and
(c) processing the bare copper foil to yield the electrodeposited copper foil, so that the electrodeposited copper foil has:
(i) a lightness L* value of a nodule untreated side, based on the L*a*b color system, in the range of 75 to 90;
(j) a normal tensile strength in the range of 40 kgf/mm2 to 55 kgf/mm2; and
(k) a degree of curl, as measured by the lamination curl test, is in the range of 0.45 mm to 3.0 mm;
wherein the processing comprises a surface treatment process.

US Pat. No. 10,190,224

ANTI-EXPLOSION GAS GENERATOR FOR HEALTH USE

1. An anti-explosion gas generator for health use, comprising:an electrolysis device for electrolyzing water to produce a gas mixture comprising hydrogen for being transferred in a sealed tube and inhaled by a user, the electrolysis device comprising two electrodes and the electrodes having interchangeable polarity;
a power supply electrically connected to the electrolysis device, adapted for supplying power to the electrolysis device;
a humidifier coupled to the electrolysis device for receiving the gas mixture comprising hydrogen to produce a filtered gas;
an atomized/volatile gas mixing tank coupled to the humidifier for receiving the filtered gas, wherein the atomized/volatile gas mixing tank generates water vapor which is mixed with the filtered gas to produce a health gas, wherein the atomized/volatile gas mixing tank further comprises an oscillator for atomizing or vaporizing a liquid to produce the water vapor, and selectively outputs either the filtered gas or the health gas by turning on/off the oscillator; and
a flow controller coupled to the electrolysis device, adapted for controlling a flow rate of the gas mixture comprising hydrogen, wherein during electrolysis the flow rate is adjustable and greater than 0.1 L/min;
wherein the humidifier further comprises a pressure sensor and a release valve electrically connected to the pressure sensor, the pressure sensor adapted for detecting whether the pressure of the filtered gas excesses a dangerous level, the pressure sensor would open the release valve to reduce the pressure of the filtered gas when the pressure excesses the dangerous level.

US Pat. No. 10,190,223

GAS GENERATOR

1. A gas generator, comprising:an electrolytic cell, containing an electrolyzed water including an electrolyte, wherein the electrolytic cell is used for electrolyzing the electrolyzed water to generate a gas with hydrogen, and the electrolytic cell has an outlet for outputting the gas with hydrogen; and
a water-blocking device, configured on the outlet, wherein the water-blocking device is used for preventing the electrolyzed water from flowing out of the electrolytic cell when the electrolytic cell is tilted by a tilt angle.

US Pat. No. 10,190,222

CORROSION INHIBITORS

Ecolab USA Inc., St. Pau...

9. A method for inhibiting corrosion of a metal surface in contact with an aqueous system, the method comprising adding to the aqueous system a compound of formula (I),
wherein each of X and Y is the same or different, and is selected from the group consisting of hydrogen, C1-C16 alkyl, aryl, C2-C16 alkenyl, C2-C16 alkynyl, heteroaryl, C3-C8 cycloalkyl, benzyl, alkylheteroaryl, halogen, halosubstituted alkyl, amino, aminoalkyl, cyano, alkoxy, hydroxyl, thiol, alkylthio, carbonyl, nitro, phosphoryl, phosphonyl, and sulfonyl;
each of R1 and R2 is the same or different, and is selected from the group consisting of hydrogen, deuterium, C1-C16 alkyl, aryl, C2-C16 alkenyl, C2-C16 alkynyl, heteroaryl, C3-C8 cycloalkyl, benzyl, alkylheteroaryl, halogen, hydroxyl, and carbonyl;
m is 1, 2, 3, or 4; and
n is 1, 2, or 3;
or a salt thereof.

US Pat. No. 10,190,221

PLATED STEEL SHEET FOR HOT PRESS FORMING HAVING EXCELLENT WELDABILITY AND CORROSION RESISTANCE, FORMING MEMBER, AND MANUFACTURING METHOD THEREOF

POSCO, Pohang-si, Gyeong...

1. A plated steel sheet comprising:a base steel sheet; and
a composite plating layer formed on at least one side of the base steel sheet, the composite plating layer comprising a Mn-based plating layer and an Al-based plating layer alternately formed with the Al-based plating layer being an upper most layer,
wherein the composite plating layer has a total thickness of 5 ?m to 30 ?m, and the Mn-based plating layer has a thickness accounting for 5% to 60% of the total thickness of the composite plating layer, and
wherein the Mn-based plating layer comprises at least one selected from the group consisting of chromium (Cr), zinc (Zn), beryllium (Be), magnesium (Mg), calcium (Ca), and titanium (Ti) in an amount of 5 wt % to 20 wt %.

US Pat. No. 10,190,220

FUNCTIONAL BASED REPAIR OF SUPERALLOY COMPONENTS

Siemens Energy, Inc., Or...

1. A method comprising:simultaneously melting powdered alloy material and powdered flux material on a surface of an original superalloy material to form a melt pool comprising a layer of slag covering an additive superalloy material;
cooling and solidifying the melt pool; and
removing the layer of slag to reveal a surface of the additive superalloy material;
wherein the steps of melting and cooling and solidifying are performed such that the additive superalloy material has a property that is different from a counterpart property of the original superalloy material.

US Pat. No. 10,190,218

INTEGRATED CIRCUIT SUBSTRATE CONTAINING PHOTOIMAGEABLE DIELECTRIC MATERIAL AND METHOD OF PRODUCING THEREOF

TWISDEN LTD., Tortola (V...

1. An integrated circuit substrate, comprising:at least one internal patterned mask layer defined by multiple mask units that are spaced apart by gaps on a partially or completely removable carrier; and
at least one internal conductive trace layer formed by one or more internal conductive traces that are deposited into the gaps of each internal patterned mask layer such that each gap is occupied with an internal conductive trace;
wherein the internal patterned mask layer is made of a photoimageable dielectric material that is retained in the integrated circuit substrate.

US Pat. No. 10,190,217

PLASMA FILM-FORMING METHOD AND PLASMA FILM-FORMING APPARATUS

Tokyo Electron Limited, ...

1. A plasma film-forming method comprising:placing a workpiece within a chamber;
supplying a film-forming gas into the chamber;
generating plasma within the chamber; and
exciting the film-forming gas by the plasma to form a predetermined film on the workpiece,
wherein helium gas is supplied as a plasma generating gas into the chamber together with the film-forming gas to generate plasma containing the helium gas in the chamber, and
wherein a partial pressure ratio of the film-forming gas to the helium gas is in a range of 0.15 to 2.5.

US Pat. No. 10,190,216

SHOWERHEAD TILT MECHANISM

LAM RESEARCH CORPORATION,...

1. A semiconductor substrate processing apparatus for processing semiconductor substrates comprising:a chemical isolation chamber in which individual semiconductor substrates are processed, the chemical isolation chamber including a top plate forming an upper wall of the chemical isolation chamber;
a process gas source in fluid communication with the chemical isolation chamber for supplying at least one process gas into the chemical isolation chamber;
a showerhead module which delivers the process gas from the process gas source to a processing zone of the processing apparatus wherein the individual semiconductor substrates are processed, the showerhead module including a base attached to a lower end of a stem wherein a faceplate having gas passages therethrough forms a lower surface of the base and the stem extends through a vertically extending bore in the top plate;
a substrate pedestal module configured to support the semiconductor substrate in the processing zone below the faceplate during processing of the substrate;
a bellows assembly supporting the showerhead module, the bellows assembly including a collar, a bellows and a leveling plate, the collar having a central opening aligned with the bore in the top plate, the bellows surrounding the central opening in the collar and having a lower end attached to an upper surface of the collar and an upper end attached to a lower surface of the leveling plate, the leveling plate having a central opening aligned with the bore in the top plate;
at least one showerhead tilt adjustment mechanism operable to adjust tilting of the faceplate of the showerhead module with respect to an upper surface of the substrate pedestal module adjacent the faceplate, wherein the showerhead tilt adjustment mechanism comprises a lock screw, a hollow screw, a lock plate, and a lock nut, the hollow screw having a first threaded section on an outer surface thereof and a second threaded section on the outer surface, the first threaded section having a thread pitch which is different than a thread pitch of the second threaded section, the first threaded section engaged with an internally threaded bore of the leveling plate, the second threaded section engaged with an internal thread of the lock nut, the lock screw having a lower external threaded section engaged with a threaded bore in the collar and an upper screw head engaging a shoulder of an upper socket in the hollow screw, and the lock plate movable from a first position at which the lock nut rotates with the hollow screw to a second position at which the lock nut cannot rotate, the showerhead tilt adjustment mechanism providing coarse adjustment when the lock plate is in the first position and fine adjustment when the lock plate is in the second position.

US Pat. No. 10,190,215

FLUIDIZED BED PYROCARBON COATING

On-X Life Technologies, I...

1. A system to coat substrates with a coating of uniform thickness comprising:substrates of similar asymmetrical shape to be coated, and
a container confining the substrates in a generally static orientation with one another such that the substrates are collectively positioned evenly about a central core of the container;
wherein the container is configured to allow each substrate to: (a) randomly tumble in a flowing gaseous stream based on the generally static orientation of the substrates in the container; (b) pivot about an axis of the respective substrate, (c) jiggle during the random tumbling so the respective substrate is not in constant contact with any other substrate or any portion of the container; and (d) receive a coating of generally uniform thickness on generally all portions of the respective substrate based on the random tumbling.

US Pat. No. 10,190,214

DEPOSITION APPARATUS AND DEPOSITION SYSTEM HAVING THE SAME

ASM IP Holding B.V., Alm...

1. A deposition apparatus comprising:a substrate support having a main surface on which a substrate is placed;
a body disposed on the main surface of the substrate support and comprising a hollow portion having an exposed upper portion;
a plasma electrode unit provided at an inner circumferential surface of the body and defining an upper space and a lower space of the hollow portion, the upper space being filled with an external gas; and
a gas supply unit supplying process gas to the plasma electrode unit,
wherein the body defines a gas exhaust channel therein, the gas exhaust channel extending from the lower space to an exhaust outlet provided at a top of the body, and
wherein the body defines at least one groove therein that is formed on the bottom surface of the body, and the at least one groove is configured to connect an outer region of the body and the gas exhaust channel.

US Pat. No. 10,190,213

DEPOSITION OF METAL BORIDES

ASM IP Holding B.V., Alm...

1. A method of forming a film having a metal boride comprising:providing a substrate for processing in a reaction chamber;
performing a metal precursor deposition onto the substrate, the performing the metal precursor deposition step comprises:
pulsing a metal precursor onto the substrate; and
purging an excess of the metal precursor from the reaction chamber; and
performing a decaborane precursor deposition onto the substrate, the performing the decaborane precursor deposition step comprises:
pulsing a decaborane precursor onto the substrate, wherein prior to entering into the reaction chamber, the decaborane precursor is kept at a temperature not exceeding 65° C.; and
purging an excess of the decaborane precursor from the reaction chamber;
wherein the metal precursor comprises one of: titanium tetrachloride (TiCl4), niobium pentachloride (NbCl5), tantalum pentafluoride (TaF5), and niobium pentafluoride (NbF5) and wherein prior to entering the reaction chamber, the metal halide is kept at temperature ranging between 50° C. and 120° C.;
wherein a reaction between the metal halide precursor and the decaborane precursor forms a film comprising at least one of: titanium boride (TiB), tantalum boride (TaB), or niobium boride (NbB);
wherein the metal precursor deposition step is repeated a predetermined number of times; and
wherein the decaborane precursor deposition step is repeated a predetermined number of times.

US Pat. No. 10,190,212

BROMINE-SENSITIZED SOLAR PHOTOLYSIS OF CARBON DIOXIDE

1. A composition of matter comprising a chemical compound of the formula C2O4Br4.

US Pat. No. 10,190,210

NEAR-FIELD TRANSDUCER HAVING AT LEAST ONE SECONDARY ATOM

Seagate Technology LLC, ...

1. A device having an air bearing surface (ABS), the device comprising:a near field transducer, the near field transducer comprising a peg and a disc, the peg having a region adjacent the ABS, the peg comprising:
a plasmonic material selected from gold (Au), silver (Ag), copper (Cu), ruthenium (Ru), rhodium (Rh), aluminum (Al), or combinations thereof; and
at least one other secondary atom selected from germanium (Ge), tellurium (Te), aluminum (Al), antimony (Sb), tin (Sn), mercury (Hg), indium (In), zinc (Zn), iron (Fe), copper (Cu), manganese (Mn), silver (Ag), chromium (Cr), cobalt (Co), and combinations thereof, the concentration of the at least one secondary atom being not less than 0.001 at % and not greater than 30 at % in the peg.

US Pat. No. 10,190,209

PVD APPARATUS AND METHOD WITH DEPOSITION CHAMBER HAVING MULTIPLE TARGETS AND MAGNETS

Taiwan Semiconductor Manu...

1. A system comprising:a deposition chamber with a target arrangement including a plurality of target assemblies therein, each said target assembly including a target member and at least one magnet having a north pole and a south pole oriented in a plane parallel to a surface of said target member, wherein each of the at least one magnets is an annular magnet having said north pole concentrically positioned within said south pole, each said target assembly having a separately controllable power source.

US Pat. No. 10,190,206

DUAL PHASE MAGNETIC MATERIAL COMPONENT AND METHOD OF FORMING

GENERAL ELECTRIC COMPANY,...

1. A method of preparing a magnetic component, comprising:mechanically masking pre-selected sections of a surface portion of the component, using a nitrogen stop-off material to form a masked region in the component; and
heat-treating the component in a nitrogen-rich atmosphere at a temperature greater than about 900° C. to form intermixed first and second regions in the magnetic alloy, wherein
(a) the first region comprises a magnetic phase;
(b) the second region comprises a non-magnetic phase;
(c) a concentration of carbon in both the first and second regions is zero or less than about 0.05 weight %; and
(d) the second region comprises greater than about 0.1% of nitrogen.

US Pat. No. 10,190,205

METHOD AND APPARATUS FOR FLAME SPRAYING THERMOPLASTIC POWDERS

IBIX S.R.L., Santa Maria...

1. An apparatus for flame spraying thermoplastic powders, the apparatus comprising:a spray gun configured to perform spraying of thermoplastic powders and to be fed with a liquefied petroleum gas for producing a flame to be directed on an article to be coated in order to heat a surface of said article to a predetermined working temperature, said spray gun comprising a mixing device internally defining separated discharge chambers, said separated discharge chambers being configured to be fed with said thermoplastic powders to be sprayed with a transport inert gas, with a flow of compressed air and/or nitrogen and with said liquefied petroleum gas, and said spray gun comprising a mixing chamber communicating with said separated discharge chambers;
a flame ignition device for igniting said flame, connected to said spray gun and said flame ignition device comprising a spark ignition device, and a conductor element associated with said mixing device and said conductor element being connected to said spark ignition device so as to produce a spark at said mixing chamber;
a flame detection and monitor device configured to detect and monitor a presence of said flame;
an actuator means for interrupting or enabling a feed of the liquefied petroleum gas, said flame detection and monitor device being connected, directly or indirectly, with said actuator means, said spark ignition device comprising a piezoelectric spark ignition device fixed to said mixing device, said piezoelectric spark ignition device being provided with an activation means, said flame detection and monitor device comprises a temperature detection means associated with said mixing device;
a duct for feeding said liquefied petroleum gas in communication with one of said separated discharge chambers configured to be fed with said liquefied petroleum gas, said actuator means comprising a valve associated with said duct and said valve being housed in an external tubular element mounted on an end of said spray gun so as to intersect said duct, said valve being connected with said temperature detection means and said spark ignition device being mounted in a fixed manner on said external tubular element.

US Pat. No. 10,190,203

DEVICE FOR TREATING A METAL STRIP WITH A LIQUID COATING MATERIAL

Fontaine Engineering und ...

1. A device for treating a metal strip after the metal strip has exited a costing container filled with a liquid coating material, comprisinga blower, which is arranged above the coating container, with an air outlet gap for blowing excess parts of the liquid coating material off a vertically moving surface of the metal strip after passage of the metal strip through the coating container;
an electromagnetic stabilizer, which is arranged above the blower, for stabilizing the metal strip after leaving the coating container and the blower, wherein the electromagnetic stabilizer is so arranged above the blower that a spacing between a line of action of a maximum force of the electromagnetic stabilizer on the metal strip and the air outlet gap lies in a range of 100 to 1200 millimeters; and
a horizontal cross member mounted between and attached to two vertical posts,
wherein the blower is secured to and hangs below the horizontal cross member, and
wherein the electromagnetic stabilizer is arranged between the horizontal cross member and the blower, and
wherein the electromagnetic stabilizer and the blower are independently secured to the horizontal cross member, and
wherein the electromagnetic stabilizer hangs below the horizontal cross member.

US Pat. No. 10,190,202

METHOD AND DEVICE FOR COATING A METAL STRIP

FONTAINE ENGINEERING UND ...

1. A device for coating a metal strip with a coating material, comprising:a coating container with a correction roller, wherein the coating container is fillable with a liquid coating material, for conducting through the metal strip, and wherein the coating material adheres to the surface of the metal strip to be coated;
a blowing device, which is arranged downstream of the coating container in the transport direction of the metal strip, with a slot for conducting through the metal strip and for blowing excess parts of the still liquid coating material off the surface of the metal strip;
a curvature sensor for detecting the actual curvature of the metal strip after leaving the coating container;
a control device for adjusting the correction roller against the metal strip if the amount of the actual curvature exceeds a predetermined permissible curvature threshold value;
a regulating device for regulating the actual position of the metal strip to the predetermined target centre position in the slot of the blowing device by displacing the blowing device in a plane transverse to the transport direction of the metal strip with the help of a displacing device; and
a correction roller detection device for detecting the adjusted position of the correction roller or the change thereof;
wherein the displacement of the blowing device is carried out with consideration of the adjusted position of the correction roller.

US Pat. No. 10,190,199

METHOD OF ALLOYING REACTIVE COMPONENTS

Ormco Corporation, Orang...

1. A method of making a hyperelastic single-crystal CuAlNi shape memory alloy, the method comprising:forming a melt of CuAlNi by layering a layer of aluminum adjacent to a layer of copper and a layer of nickel, and-melting the layers together;
placing a seed of a desired composition for the shape memory alloy into the melt;
drawing the seed from the melt at a controlled rate so that a solid crystal is formed at a crystallization front; and
rapidly quenching the drawn crystal to produce a single crystal beta phase.

US Pat. No. 10,190,197

OXIDATION RESISTANT HIGH-ENTROPY ALLOYS

THE TRUSTEES OF DARTMOUTH...

1. A high-entropy alloy (HEA) having a formula of FeaNibMncAldCreCf where a is 37-43 atomic %, b is 8-14 atomic %, c is 32-38 atomic %, d is 5-10.5 atomic %, e is 5-9 atomic % and f is 0-2 atomic %.

US Pat. No. 10,190,195

ALLOY POWDER FOR OVERLAY WELDING, AND WELD OVERLAY ALLOY MEMBER AND ENGINE VALVE OBTAINED USING THE SAME

TOYOTA JIDOSHA KABUSHIKI ...

1. An alloy powder for overlay welding, which is used for performing overlay welding on a surface of steel containing nitrogen, whereinthe alloy powder consists of 30% to 45% by mass of Mo, 10% to 20% by mass of Ni, 0.2% to 0.6% by mass of C, and greater than 1.0% to 2.0% by mass of Al, with the balance made up of incidental impurities and Co.

US Pat. No. 10,190,192

METHOD OF RECOVERING ACID AND PLATINUM GROUP METAL FROM LEACHING SOLUTION OF SPENT CATALYST

KOREA INSTITUTE OF GEOSCI...

1. A method of recovering acid and a platinum group metal from a leaching solution of a spent catalyst, the method comprising:filtering a leaching solution, in which a spent catalyst is leached, providing the filtered leaching solution into a concentration chamber, and heating the filtered leaching solution to recover acid included in the leaching solution;
providing a concentrated solution of the leaching solution into a substitution chamber after recovering the acid, and adding a metal having a higher ionization tendency than a platinum group metal for a substitution reaction; and
cleaning a solid, which is separated by solid-liquid separation after the substitution reaction, with acid and recovering the solid,
wherein the metal added when the substitution reaction is performed includes at least one selected from the group consisting of iron, aluminum and zinc.

US Pat. No. 10,190,191

PRODUCING A TITANIUM PRODUCT

University of Utah Resear...

1. A method for producing a titanium product, comprising:obtaining TiO2-slag;
producing the titanium product from the TiO2-slag using a metallic reducing agent at a moderate temperature under a hydrogen atmosphere at a pressure to directly produce the titanium product chemically separated from metal impurities in the TiO2-slag, wherein the titanium product comprises TiH2 and optionally elemental titanium;
removing the metal impurities from the titanium product to form a purified titanium product; and
deoxygenating the titanium product at a higher temperature above the moderate temperature and under hydrogen atmosphere using a second reducing agent which is stronger than the metallic reducing agent to produce a particulate titanium product, coarsening the particulate titanium product to a target particle size range, and cooling the particulate titanium product under a hydrogen atmosphere.

US Pat. No. 10,190,190

SYSTEMS AND METHODS FOR MONITORING METAL RECOVERY SYSTEMS

FREEPORT MINERALS CORPORA...

1. A leaching solution monitoring system comprising:a first leaching solution distribution system interface fluidly coupling at least one leaching solution monitoring module to a pipe of a leaching solution distribution system;
a flow meter in fluid communication with the first leaching solution distribution system interface and in fluid communication with a 3-way pressure regulator comprising a 3-way valve;
a transmitter configured to transmit a data to a gateway; and
a processor receiving the data from the gateway,
wherein the leaching solution monitoring system is configured to receive a leaching solution from the first leaching solution distribution system, and allow the leaching solution to be distributed to the leaching solution distribution system.

US Pat. No. 10,190,189

SCANDIUM RECOVERY PROCESS

SUMITOMO METAL MINING CO....

1. A method of recovering scandium, comprising:a washing step of washing a mixture containing scandium hydroxide, scandium oxide and/or scandium carbonate and manganese hydroxide, manganese oxide and/or manganese carbonate; and
a dissolution step of dissolving a post-washing sediment containing a scandium compound obtained after washing in the washing step in an acid to leach the scandium in the post-washing sediment into the acid solution, and thereby obtaining a scandium solution and a dissolution residue,
wherein the washing step comprises a step of washing the mixture with water until the pH of a post-washing liquid obtained after washing in the washing step becomes 6 or more.

US Pat. No. 10,190,188

MIXING METHOD AND DEVICE FOR SOLVENT EXTRACTION, ESPECIALLY IN HYDROMETALLURGICAL PROCESSES

TURBULENT TECHNOLOGIES LT...

1. A method of solute extraction, the method comprising:rotating an impeller so as to mix a first liquid and a second liquid in a reactor vessel said mixing at an average energy dissipation rate of at least 0.3 W/Kg and less than 20 W/Kg so that after the mixing an emulsion of the first and second liquids is present in the reactor vessel; said mixing of said first and second liquids continuing long enough to transfer at least some of said solute from said first liquid to said second liquid in said emulsion, wherein the mixing is performed so that:
i. a volume of said reactor having a local energy dissipation rate of between 2 to 20 W/Kg is at least 1%;
ii. a volume of said reactor having a local energy dissipation rate of greater than 20 W/kg is less than 0.01%; and
iii. said impeller has a blade width W a blade length L and a blade number k such that the product of said length squared and said width and said blade number is greater than 2.0% of the volume of said reactor.

US Pat. No. 10,190,187

MANUFACTURING METHOD FOR VERY HIGH-STRENGTH, COLD-ROLLED, DUAL-PHASE STEEL SHEETS

ARCELORMITTAL, Luxembour...

1. A manufacturing method for a cold-rolled and annealed Dual-Phase steel sheet, comprising the steps of:supplying a steel sheet having a composition comprising:
0.055%?C?0.095%;
2%?Mn?2.6%;
0.005%?Si?0.35%;
S?0.005%;
P?0.050
0.1?Al?0.3%;
0.05%?Mo?0.25%;
0.2%?Cr?0.5%;
Cr+2Mo?0.6%;
Ni?0.1%;
0.010?Nb?0.040%;
0.010?Ti?0.050%;
0.0005?B?0.0025% and
0.002%?N?0.007%,
a remainder of the composition comprising iron and the inevitable impurities resulting from smelting;
casting the steel sheet as a semi-finished product;
bringing the semi-finished product to a temperature TR in which 1150° C. ?TR?1250° C.;
hot-rolling the semi-finished product with an end-of-rolling temperature TFL ?Ar3 to obtain a hot-rolled product;
coiling the hot-rolled product at a temperature Tbob in which 500° C. ?Tbob ?570° C.;
descaling the hot-rolled product;
cold-rolling with a reduction from 30 to 80% to obtain a cold-rolled product;
heating the cold-rolled product at a rate 1° C./s?Vc ?5° C/s to an annealing temperature TM in which Ac1+40° C. ?TM ?Ac3-30° C. at which the product is held for a time 30s?tM?300s so as to obtain a heated and annealed product with a structure comprising austenite and a non-recrystallized ferrite fraction less than or equal to 15%;
cooling the product to a temperature less than a temperature Ms at a rate V high enough for all of the austenite to transform to martensite;
the steel sheet having a tensile strength between 980 and 1100 MPA and a microstructure consisting of 40 to 65% ferrite, 35 to 50% martensite and 0 to 10% bainite.

US Pat. No. 10,190,185

HARDENING METHOD OF ANNULAR WORKPIECE

JTEKT CORPORATION, Osaka...

1. A hardening method for an annular workpiece made of metal, comprising:a heating process that heats the annular workpiece to a hardening temperature;
an analyzing process that obtains a diameter of the annular workpiece heated to the hardening temperature, and divides the heated annular workpiece into at least a small diameter portion and a large diameter portion based on the obtained diameter; and
a cooling process that injects cooling liquid under an injection condition toward the annular workpiece that has been divided into at least the large diameter portion and the small diameter portion in the analyzing process such that a dimensional difference between the large diameter portion and the small diameter portion decreases, the injection condition for the large diameter portion being different from the injection condition for the small diameter portion, wherein
in the cooling process, the injection condition of the cooling liquid is adjusted by changing at least one of an injection quantity of the cooling liquid per unit time, an injection start timing of the cooling liquid, and an injection angle of the cooling liquid; and
the division of the large diameter portion and the small diameter portion is made through either process A or process B:
Process A:
determining a virtual center of the heated workpiece;
measuring each position in a circumferential direction of an outer periphery or an inner periphery of the heated workpiece;
obtaining a distance between the virtual center and each position in the circumferential direction of the outer periphery or the inner periphery of the workpiece;
converting the obtained distance into a coordinate data in a XY coordinates with the virtual center as an origin;
approximating the coordinate data by a method of least squares and calculating a circle which approximates an outer peripheral shape or an inner peripheral shape of the workpiece;
calculating a distance from a central coordinate of the approximate circle to each of the positions in the circumferential direction of the outer periphery or the inner periphery of the workpiece as a radius of each of the positions in the circumferential direction of the outer periphery or the inner periphery of the workpiece;
calculating a reference radius which divides the large diameter portion from the small diameter portion based on a first radius of a first virtual circle and a second radius of a second virtual circle, the first virtual circle being a circle which is centered around the central coordinate and in which a maximum value among the radii at the positions in the circumferential direction of the outer periphery or the inner periphery of the workpiece obtained is taken as a radius of the first virtual circle, the second virtual circle being a circle which is centered around the central coordinate and in which a minimum value among the radii at the positions in the circumferential direction of the outer periphery or the inner periphery of the workpiece obtained is taken as a radius of the second virtual circle;
calculating an average of the radius of the first virtual circle and the radius of the second virtual circle as a reference radius;
virtually dividing the work piece into a plurality of workpiece fragments such that central angles of the workpiece fragments in the circumferential direction of the first virtual circle or the second virtual circle are equal;
calculating an average value of the radii of the positions in the circumferential direction of the outer periphery or the inner periphery of the workpiece for each of the workpiece fragments;
dividing a workpiece fragment of which the average value of the radii is greater than the reference radius as a large diameter portion and dividing a workpiece fragment of which the average value of the radii is smaller than or equal to the reference radius as a small diameter portion;
Process B:
determining a virtual center of the heated workpiece;
measuring each portion in a circumferential direction of an outer periphery or an inner periphery of the heated workpiece;
obtaining a distance between the virtual center and each position in the circumferential direction of the outer periphery or the inner periphery of the workpiece; converting the obtained distance into a coordinate data in a XY coordinates with the virtual center as an origin;
approximating the coordinate data by a method of least squares and calculating a circle which approximates an outer peripheral shape or an inner peripheral shape of the workpiece;
calculating a distance from a central coordinate of the approximate circle to each of the positions in the circumferential direction of the outer periphery or the inner periphery of the workpiece as a radius of each of the positions in the circumferential direction of the outer periphery or the inner periphery of the workpiece; virtually dividing the work piece into a plurality of workpiece fragments such that central angles of the workpiece fragments in the circumferential direction of the workpiece are equal;
calculating an average value of the radii of the positions in the circumferential direction of the outer periphery or the inner periphery of the workpiece for each of the workpiece fragments;
dividing a workpiece fragment of which the average value of the radii is greater than a radius of the approximate circle as a large diameter portion and dividing a workpiece fragment of which the average value of the radii is smaller than or equal to the radius of the approximate circle as a small diameter portion.

US Pat. No. 10,190,184

METHOD FOR PRODUCING A PROFILE AND A MANUFACTURING SYSTEM FOR PRODUCING A PROFILE

THYSSENKRUPP STEEL EUROPE...

1. A method for producing a profile, comprising the following method steps:providing a workpiece,
shaping the workpiece,
joining the workpiece,
coating the workpiece,
heating the workpiece, and
at least partially hardening the workpiece,
wherein the coating method step is carried out temporally after the joining method step and temporally before the heating method step and the coated workpiece is hardened in a shaping manner in a hardening tool.

US Pat. No. 10,190,165

HONEYCOMB TUBE

Cepheid, Sunnyvale, CA (...

1. A method comprising:providing a reaction tube, wherein the reaction tube comprises a planar frame defining a fluidic path including a well chamber comprising a plurality of wells between a first planar substrate and a second planar substrate, wherein the planar frame extends between a first end and a second end opposite the first end, a fluidic interface disposed along the first end of the reaction tube, the fluidic interface comprising a fluidic inlet and a fluidic outlet of the fluidic path;
introducing a liquid sample through the fluidic inlet of the fluidic interface of the reaction tube and advancing the liquid sample along the fluidic path via application of pressure to the fluidic inlet or the fluidic outlet of the fluidic interface;
filling a pre-amplification chamber of the fluidic path with the liquid sample by advancing the liquid sample along the fluidic path, the pre-amplification chamber being an enlarged portion of the fluidic path disposed along the fluidic path between the fluidic inlet and the well chamber so as to allow amplification of the liquid sample in the pre-amplification chamber before entering the well chamber and filling the plurality of wells;
filling the well chamber along the fluidic path with the liquid sample by further advancing the liquid sample along the fluidic path thereby depositing the fluid liquid sample within a plurality of wells of the well chamber; and
evacuating at least a portion of the liquid sample from the well chamber outside of the plurality of wells via application of pressure to the fluidic inlet or the fluidic outlet of the fluidic interface such that at least some of the liquid sample remains deposited within the plurality of wells.

US Pat. No. 10,190,161

APPARATUS AND METHOD FOR NUCLEIC ACID SEQUENCING BASED ON NANOWIRE DETECTORS

STMICROELECTRONICS S.R.L....

1. An apparatus for nucleic acid sequencing, comprising:a base-detection device in a detection site, the base-detection device being configured to detect bases of a portion of a nucleic acid strand at the detection site;
a conveying device configured to extend the nucleic acid strand and to cause the nucleic acid strand to slide through the detection site along a path; and
a structural layer having a first portion enclosing a first portion of the path, a second portion enclosing a second portion of the path, and an opening between the first portion and the second portion of the structural layer, the opening being aligned with the detection site;
wherein the base-detection device comprises a plurality of nanowire detectors arranged along the path, each nanowire detector of the plurality of nanowire detectors including a respective nanowire and one or more nucleic acid probes, which are fixed to the respective nanowire, each nucleic acid probe of the one or more nucleic acid probes fixed to the respective nanowire having the same sequence of nucleic acid bases.

US Pat. No. 10,190,159

METHODS AND SYSTEMS FOR NUCLEIC ACID SEQUENCING BY TUNNELING RECOGNITION

Roche Sequencing Solution...

1. A method of analyzing a nucleic acid molecule, the method comprising:attaching the nucleic acid molecule to a protein and a particle having a first diameter;
moving a portion of the nucleic acid molecule into an aperture defined by a first insulator, the aperture having a second diameter less than the first diameter, and the portion comprising a nucleotide;
applying a voltage across a first electrode and a second electrode;
contacting the portion of the nucleic acid molecule to both the first electrode and the second electrode within the aperture;
measuring a current through the first electrode, the portion of the nucleic acid molecule, and the second electrode; and
identifying the nucleotide of the portion of the nucleic acid molecule based on the current.

US Pat. No. 10,190,158

SYSTEMS AND METHODS FOR SELECTIVELY ADDRESSING SPARSELY ARRANGED ELECTRONIC MEASUREMENT DEVICES

Pacific Biosciences of Ca...

1. An integrated circuit comprising:a substrate;
a plurality of sectors arranged on the substrate, wherein each sector in the plurality of sectors comprises:
a programmable switch controller;
a counter bias line;
an amplifier input line;
a plurality of nano-electronic measurement devices spatially arranged on the substrate, wherein
each respective nano-electronic measurement device in the plurality of nano-electronic measurement devices includes a source that is coupled to the counter bias line and a drain that is coupled to the amplifier input line thereby obtaining an electrical signal on the drain of the respective nano-electronic measurement device,
the electrical signal is any one of a discrete set of electrical signals,
an identity of the electrical signal in the discrete set of electrical signals is determined by an electrical interaction between the corresponding nano-electronic measurement device and a particular charge label in a plurality of charge labels; and
a plurality of switches, wherein each switch in the plurality of switches gates the electrical signal between the drain of a corresponding nano-electronic measurement device in the plurality of nano-electronic measurement devices and the amplifier input line between
(i) an on state, in which the electrical signal at the drain of the corresponding nano-electronic measurement device is delivered to the amplifier input line, and
(ii) an off state, in which the electrical signal at the drain of the corresponding nano-electronic measurement device is not delivered to the amplifier input line, wherein
each respective switch in the plurality of switches is independently wired to the programmable switch controller thereby causing the respective switch to be in one of the on state and the off state responsive to the programmable switch controller.

US Pat. No. 10,190,157

MODIFIED NUCLEOTIDE LINKERS

Illumina Cambridge Limite...

1. A nucleoside or nucleotide covalently attached to a fluorophore through a linker, wherein said linker comprises a structure of formula (I) or (II), or combination of both:
wherein
R1 is optionally substituted C1-6 alkyl;
R2 is hydrogen or optionally substituted C1-6 alkyl;
R3 is optionally substituted C1-6 alkyl, —NR5—C(?O)R6, or —NR7—C(?O)—OR8;
R4 is hydrogen or optionally substituted C1-6 alkyl;
each R5 and R7 is independently hydrogen or optionally substituted C1-6 alkyl;
each R6 and R8 is independently optionally substituted C1-6 alkyl;
each of the methylene repeating unit in

 is optionally substituted;
X is methylene (CH2), oxygen (O), or sulfur (S);
m is an integer of 0 through 20;
n is an integer of 1 through 20; and
p is an integer of 1 through 20.

US Pat. No. 10,190,155

MOLECULAR TAG ATTACHMENT AND TRANSFER

NuGEN Technologies, Inc.,...

1. A method of determining a modification of a DNA sample, the method comprising:preparing a double-stranded DNA fragment linked with a plurality of oligonucleotide adaptors, the double-stranded DNA fragment comprising a nucleic acid sequence of interest;
denaturing the double-stranded DNA fragment, thereby generating a first strand DNA fragment and a second strand DNA fragment;
annealing a first probe to the first strand DNA fragment, the first probe comprising a probe oligonucleotide sequence complementary to and hybridizing to a first probe target region associated with the nucleic acid sequence of interest;
extending the first probe with a DNA polymerase using the first strand DNA fragment as a template, thereby generating a probe extension sequence;
annealing a primer or a second probe to the second strand DNA fragment, the primer and the second probe comprising a tag sequence;
generating an extension sequence using the primer or the second probe, the extension sequence including the tag sequence or a complement of the tag sequence; and
sequencing the extension sequence and the probe extension sequence, thereby determining the modification of the DNA sample based on existence or absence of the tag sequence or a complement of the tag sequence, wherein the annealing the primer or the second probe to the second strand DNA fragment and generating the extension sequence using the primer or the second probe comprises:
annealing the second probe to the second strand DNA fragment, the second probe comprising a non-extendable probe sequence and a tag sequence, the non-extendable probe sequence complementary to and hybridizing to a second probe target region associated with the nucleic acid sequence of interest;
annealing a primer sequence to a 3? end of the second strand DNA fragment;
extending the primer sequence with the DNA polymerase using the second strand DNA fragment as a template, thereby generating a primer extension sequence; and
ligating the primer extension sequence and the second probe, thereby generating the extension sequence comprising the tag sequence.

US Pat. No. 10,190,150

DETERMINING ANALYTE CONCENTRATION FROM VARIANT CONCENTRATION DISTRIBUTION IN MEASURABLE SPECIES

ASCENSIA DIABETES CARE HO...

1. An electrochemical method for determining an analyte concentration in a sample, comprising:receiving a sample including a biological fluid at a sample reservoir, the sample reservoir having a reagent layer including an enzyme disposed in the sample reservoir and a pair of electrodes partially or completely disposed in the sample reservoir such that the sample contacts both the enzyme and the pair of electrodes responsive to being received at the sample reservoir, the contact between the sample and the enzyme causing a reaction between the enzyme and an analyte in the sample such that the analyte begins to undergo a redox conversion to electrochemically form a measurable species from the reaction between the enzyme and the analyte, the electrochemical forming of the measurable species resulting from a transfer of electrons from or to the analyte during the redox conversion of the analyte;
applying, by a signal generator, an electrical input signal having an excitation and a relaxation to the sample via the pair of electrodes after an incubation period, the incubation period being less than a reference period, wherein at the end of the reference period (i) all of the analyte has undergone the redox conversion to the measureable species and (ii) the measurable species has a constant concentration distribution, and wherein at the end of the incubation period (i) a portion but not all of the analyte has undergone the redox conversion to the measurable species and (ii) the measurable species has a variant concentration distribution, the reference period being based on a height of the sample reservoir, a volume of the sample reservoir, a thickness of the reagent layer, or any combination thereof, the incubation period beginning when the sample is received at the reservoir, the applying of the electrical input signal producing an electrical output signal that is based on the analyte concentration of the sample;
measuring, by a processor, the electrical output signal; and
determining, by the processor, the analyte concentration of the sample as a function that includes the measured electrical output signal.

US Pat. No. 10,190,149

KIT AND METHOD FOR MEASURING THE ACTIVITY OF DEOXYNUCLEOSIDE KINASE

Biovica International AB,...

1. A kit comprising: (i) a DNA dependent DNA polymerase, (ii) at least one natural deoxynucleoside, and (iii) a detection system comprising a DNA template molecule, a DNA primer molecule, and a fluorescent moiety capable of being displaced from, or bound to, dsDNA synthesized by said DNA dependent DNA polymerase.

US Pat. No. 10,190,147

FAST DETECTION OF THE PRESENCE OF A TARGET MICROBE IN A LIQUID SAMPLE

ELEMENTAL SCIENTIFIC, INC...

1. A method comprising:holding a plurality of liquid samples prepared by adding an indicator configured to produce a characteristic change in light from the plurality of liquid samples when a target microbe metabolizes the indicator while the plurality of liquid samples is incubated, the plurality of liquid samples being held in a tray including a plurality of compartments partitioned one from another;
automatically sensing light from each of the plurality of liquid samples while the plurality of liquid samples is incubated; and
detecting the characteristic change in light from each of the plurality of liquid samples based on the sensed light from each of the plurality of liquid samples;
detecting a number of occurrences of the characteristic change in light from the plurality of liquid samples as the plurality of liquid samples is incubated;
determining whether the detected number of occurrences of the characteristic change in light exceeds a threshold number of occurrences of the characteristic change in light, the threshold number of occurrences of the characteristic change in light corresponding to a concentration of the target microbe within the liquid samples indicative of the presence of the target microbe; and
providing an indication that a presence of the target microbe has been detected based upon the determination,
wherein at an intermediate time interval prior to the end of the incubation period, the threshold number of occurrences of the characteristic change in light is a first threshold number associated with the intermediate time interval and the concentration of the target microbe is indicated by a number of occurrences of the characteristic change in light from a predetermined number of the plurality of liquid samples that exceeds the first threshold number,
wherein at the end of the incubation period, the threshold number of occurrences of the characteristic change in light is a second threshold associated with the entire incubation period and the concentration of the target microbe is indicated by a number of occurrences of the characteristic change in light from the plurality of liquid samples that exceeds the second threshold number.

US Pat. No. 10,190,146

METHOD OF CORRECTING FOR OXYGEN EFFECT

Ascensia Diabetes Care Ho...

1. A method for correcting the oxygen effect in determining the concentration of glucose in a fluid using an electrochemical test sensor, the method comprising the acts of:providing a test sensor, the test sensor comprising first and second working electrodes, and a counter electrode, the first working electrode including glucose oxidase, an oxidized form of a mediator and peroxidase, the second working electrode including glucose oxidase and the oxidized form of the mediator;
contacting the fluid with the test sensor;
measuring a first current from the first working electrode from a reduced form of the mediator;
measuring a second current from the second working electrode from the reduced form of the mediator; and
determining the concentration of glucose and correcting for the oxygen effect by using the first current measurement and the second current measurement.

US Pat. No. 10,190,114

LOW RESOURCE SAMPLE PROCESSOR CONTAINING HEAT-ACTIVATED SURFACE TENSION VALVES

VANDERBILT UNIVERSITY, N...

1. A method of processing a fluid sample comprising an analyte, the method comprising the steps of:(a) providing a device comprising a plurality of sequential chambers connected by tubing, each of said sequential chambers comprising a fluid and separated by plug material that is solid at temperatures below about 45° C., wherein a first reaction chamber of the plurality of sequential chambers comprises a magnetic or paramagnetic particle having a reactant on its surface;
(b) introducing into said first reaction chamber the fluid sample comprising the analyte;
(c) incubating said first reaction chamber under conditions sufficient to permit binding of said reactant with said analyte in said sample;
(d) heating said plug material in said device to a temperature above 45° C., thereby rendering at least a portion of said plug material into a liquid state, thereby forming a surface tension valve, wherein heating is performed by placing a heated magnet in proximity of said plug material;
(e) transporting said magnetic or paramagnetic particle from said first reaction chamber, into at least a second chamber of said plurality of sequential chambers through tubing disposed therebetween, wherein transporting comprises passing said magnet along said tubing to effect movement of said magnetic or paramagnetic particle; and
(f) detecting interaction of said analyte with said reactant by determining the presence or absence of said analyte in said second or a subsequent chamber of said plurality of said sequential chambers.

US Pat. No. 10,190,107

MODIFIED ?-GALACTOSIDASE

Amano Enzyme Inc., Nagoy...

1. A ?-galactosidase comprising an amino acid sequence which is different from a reference ?-galactosidase amino acid sequence in that one or more amino acids selected from the group consisting of the following (1) to (3) is/are proline, wherein the reference ?-galactosidase amino acid sequence shows a 90% or more identity to the amino acid sequence of SEQ ID NO: 4:(1) an amino acid corresponding to lysine at position 166 of the amino acid sequence of SEQ ID NO: 4;
(2) an amino acid corresponding to glycine at position 307 of the amino acid sequence of SEQ ID NO: 4; and
(3) an amino acid corresponding to alanine at position 833 of the amino acid sequence of SEQ ID NO: 4.

US Pat. No. 10,190,101

PRODUCTION OF LACTIC ACID FROM ORGANIC WASTE OR BIOGAS OR METHANE USING RECOMBINANT METHANOTROPHIC BACTERIA

STRING BIO PRIVATE LIMITE...

1. A recombinant methanotrophic bacterium capable of producing lactic acid from organic waste or biogas or methane, comprisinga heterologous nucleic acid or gene encoding for lactate dehydrogenase (ldh) enzyme, having the sequence of SEQ ID NO: 1, 3, or 5, or a combination thereof.

US Pat. No. 10,190,090

METHODS AND SYSTEMS FOR FORMING STABLE PARTICLES FROM SUSPENDED SOLIDS PRODUCED BY ETHANOL FERMENTATION

WATER SOLUTIONS, INC., S...

1. A method for forming stable particles from suspended solids produced by ethanol fermentation, the method comprising:providing a liquid fraction from ethanol fermentation, the liquid fraction comprising one or more of solids and suspended solids, wherein the liquid comprises thin stillage;
adjusting a pH of the liquid fraction to a pH in the range from 3.5 to 7;
adding a potassium metabisulfite reducing agent to the pH adjusted liquid fraction;
adding a high molecular weight anionic polymer to form stable particles of one or more of solids and suspended solids, wherein the high molecular weight anionic polymer comprises a molecular weight of about 15 million Da or more; and
free draining to separate the stable particles from a liquid portion.

US Pat. No. 10,190,089

MODULAR SYSTEM AND METHOD FOR DETECTING MICROORGANISMS

3M Innovative Properties ...

1. A method for detecting a microorganism, the method comprising(i) inserting a culture device into a modular system, the modular system comprising a plurality of freestanding modules, the plurality of freestanding modules including:
a freestanding first module configured to hold a stomacher bag comprising a liquid sample;
a freestanding second module configured to transfer the liquid sample to the culture device; and
a freestanding third module comprising a housing and a detector, wherein a first slot, a second slot, and a third slot are formed in the housing of the freestanding third module, the freestanding third module configured to receive the culture device through the first slot;
interlocking features to align two or more freestanding modules of the plurality of freestanding modules; and
a data processor, wherein the data processor is programmed to:
receive at least one user-established preset criterion that defines a quantity of microorganism colonies;
receive colony count information from the detector;
compare the colony count information to the at least one preset criterion to determine whether one or more conditions exist in the culture device;
configure the freestanding third module to eject the culture device through the second slot when the one or more conditions exist in the culture device; and
configure the freestanding third module to eject the culture device through the third slot when the one or more conditions do not exist in the culture device;
(ii) analyzing the culture device for colony count information with the detector; and
(iii) provide the colony count information from the detector to the data processor.

US Pat. No. 10,190,088

ORGANISM CULTURING SYSTEM AND ORGANISM CULTURING METHOD

Hitachi, Ltd., Tokyo (JP...

12. A method for culturing an organism, comprising:storing a light-absorbing solution that absorbs more light in a second wavelength range than light in a first wavelength range in a liquid storage vessel, wherein the second wavelength range is at a shorter wavelength side than the first wavelength range,
storing a culture solution containing a photosynthetic organism to be cultured in a culture vessel,
disposing the culture vessel in the liquid storage vessel,
measuring the quantity of light that the culture vessel receives separately for different wavelength ranges using a first measuring unit,
measuring the quantity of external light surrounding the liquid storage vessel using a second light quantity measuring unit, and
controlling the liquid depth from the surface of the light-absorbing solution to the culture vessel in the liquid storage vessel based on the quantity of external light surrounding the liquid storage vessel and on the quantity of light measured for different wavelength ranges on the surface of the culture vessel,
wherein light intensity is decreased while the proportion of light in the first wavelength range and the second wavelength range is maintained, by controlling the liquid depth.

US Pat. No. 10,190,087

SINGLE USE CONTROLLED ENVIRONMENT MODULE

GE HEALTHCARE BIO-SCIENCE...

1. A single use, controlled environment manufacturing module comprising:a sealed bag formed of a substantially flexible material, the sealed bag having sterile interior and an exterior and capable of being inflated with air or gas, such that an environment within the sealed bag is sterile and is segregated from an ambient environment outside of the sealed bag;
at least one external connector, the at least one external connector comprising at least one of an aseptic connector and a tubing connector that extend from the exterior of the sealed bag to the interior of the sealed bag;
at least one set of access ports configured to provide hand-access to the interior of the sealed bag; and
a central controller operative to control and monitor the environment within the sealed bag and a manufacturing process conducted within the sealed bag;
wherein a sterile environment is achieved and maintained within the bag without clean-in-place or sterilization-in-place operations.

US Pat. No. 10,190,085

MICRO-INCUBATION SYSTEMS FOR MICROFLUIDIC CELL CULTURE AND METHODS

EMD Millipore Corporation...

1. A method of culturing cells, comprising:disposing cells into a culture chamber, the culture chamber connected to a plurality of microfluidic channels, the culture chamber and microfluidic channels configured into a culture unit on a well plate;
interfacing the well plate with a microincubator manifold, the microincubator manifold having a gasket for providing a removable air-tight seal to the well plate, and a heat exchange module, wherein the manifold seals to the well plate, thereby enclosing an incubation volume of gas, wherein the heat exchange module provides a controlled temperature above and in communication with the culture chamber; and
observing and/or assaying the cells in the culture chamber, wherein the microincubator manifold comprises a transparent window in a region disposed above the culture chamber.

US Pat. No. 10,190,083

METHOD AND DEVICE FOR PATTERNING AN INTERFACE

THE REGENTS OF THE UNIVER...

1. A coating interfacing device (999) for forming a defined interface between separated coatings, the device (999) comprising:a well (100) comprising an elastomeric bottom surface (200),
a slit (300) formed into the elastomeric bottom surface (200),
a removable divider (400) inserted into the slit (300) to create a closeable gap (310) and to divide the well (100) into a first compartment (110) and a second compartment (120), wherein the first compartment (110) comprises a first elastomeric bottom surface (210) and the second compartment (120) comprises a second elastomeric bottom surface (220),
the first elastomeric bottom surface (210) and the second elastomeric bottom surface (220) each lined with a designated coating,
wherein the divider (400) is removed to close the gap (310), whereby the designated coating lined on the first elastomeric bottom surface (210) interfaces with the designated coating lined on the second elastomeric bottom surface (220).

US Pat. No. 10,190,082

MULTIWELL PLATE

Seng Enterprises Ltd., L...

1. A multiwell plate comprising:a unitary structure including a plurality of wells and a plurality of picowells at the bottoms of the wells, wherein the picowells are formed of a transparent hydrogel and are transparent;
a transparent gel covering the plurality of hydrogel-formed picowells.

US Pat. No. 10,190,081

VOLATILE ORGANIC COMPOUND RECOVERY SYSTEM AND METHOD

EcoPAS LLC, Irvine, CA (...

1. A method of making a fermented beverage, comprising, during fermentation of a must in a fermentation vessel:feeding vapors from a head space of the fermentation vessel to a condenser having a first condenser module and a second condenser module;
controlling an inlet of the second condenser module to open or close based on a flow rate of the vapors from the head space of the fermentation vessel;
condensing a portion of the vapors in the condenser to thereby produce a mixed-phase stream comprising CO2 and an alcohol-containing condensate;
feeding the mixed-phase stream to a collection tank;
sequestering the condensate from the mixed-phase stream through a first port of the collection tank; and
removing CO2 from the mixed-phase stream through a second port of the collection tank.

US Pat. No. 10,190,080

METHOD FOR CLEANING SYSTEMS

Thonhauser GmbH, Giesshe...

1. A method for cleaning a system and detecting a state of cleanliness of the system by monitoring a color change and comparing the color change to a setpoint value, the method comprising the following steps:a) providing a cleaning composition comprising at least one oxidizing agent for oxidizing impurities and containing a color indicator;
b) continuously conducting the cleaning composition through the system;
c) determining color values F of the cleaning composition at fixed time intervals and at one or more locations including at least after exit of the cleaning composition from the system;
d) calculating differences ?F between color values obtained from two consecutive determinations;
e) before putting a clean system into operation, determining color values until a difference ?F=0 is determined, whereafter the color value measured last is defined as an inherent system value FA and a maximum tolerable deviation from this value is specified as a setpoint value ?FA for cleaning; and
f) cleaning the system after its operation is carried out until the difference ?FA between two consecutive color values FR is equal to or smaller than ?FA, which shows that the system is clean.

US Pat. No. 10,190,079

COMPOSITIONS CONTAINING ONE OR MORE POLY ALPHA-1,3-GLUCAN ETHER COMPOUNDS

E I DU PONT DE NEMOURS AN...

1. A composition comprising a cellulase and a poly alpha-1,3-glucan compound comprising the structure:
wherein
(i) n is at least 6,
(ii) each R is independently H or a positively charged organic group, wherein at least one R group is a positively charged organic group,
(iii) the poly alpha-1,3-glucan compound has a degree of substitution of about 0.05 to about 3.0 with the positively charged organic group, and
(iv) at least 90% of the glycosidic linkages of the poly alpha-1,3-glucan compound are alpha-1,3 glycosidic linkages.

US Pat. No. 10,190,078

DETERGENT

1. An automatic dishwashing detergent composition comprising:a) from about 0.1% to about 20% by weight of a cleaning surfactant selected from the group consisting of an anionic surfactant, a zwitterionic surfactant, an amphoteric surfactant, and mixtures thereof;
b) from about 0.1% to about 20% by weight of a cleaning amine,wherein the amine is a polyetheramine selected from the group consisting of polyetheramines of Formula (I), Formula (II), Formula (III) and a mixture thereof:
wherein each of R1-R12 is independently selected from H, alkyl, cycloalkyl, aryl, alkylaryl, or arylalkyl, wherein at least one of R1-R6 and at least one of R7-R12 is different from H, each of A1-A9 is independently selected from linear or branched alkylenes having about 2 to about 18 carbon atoms, each of Z1-Z4 is independently selected from OH or NH2, wherein at least one of Z1-Z2 and at least one of Z3—Z4 is NH2, wherein the sum of x+y is in the range of about 2 to about 200, wherein x?1 and y?1, and the sum of x1+y1 is in the range of about 2 to about 200, wherein x1?1 and y1?1

wherein R is selected from H or a C1-C6 alkyl group, each of k1, k2, and k3 is independently selected from 0, 1, 2, 3, 4, 5, or 6, each of A1, A2, A3, A4, A5, and A6 is independently selected from a linear or branched alkylene group having from about 2 to about 18 carbon atoms or mixtures thereof, x?1, y?1, and z?1, and the sum of x+y+z is in the range of from about 3 to about 100, each of Z1, Z2, and Z3 is independently selected from NH2 or OH, where at least two of Z1, Z2, and Z3 are NH2; and the polyetheramine has a weight average molecular weight of from about 150 to about 1000 grams/mole.

US Pat. No. 10,190,076

METHODS FOR PRODUCING A HIGH PROTEIN CORN MEAL FROM A WHOLE STILLAGE BYPRODUCT AND SYSTEM THEREFORE

Fluid Quip, Inc., Spring...

1. A method for recovering oil from a whole stillage byproduct produced via a corn dry-milling process, the method comprising:in a corn dry-milling process for making alcohol, separating the whole stillage byproduct into an insoluble solids portion and a thin stillage portion, which includes free oil and protein;
prior to any evaporation step, separating out a lighter water soluble solids portion, which includes the oil, from heavier constituents, including the protein, in the thin stillage portion, via weights, wherein the heavier constituents, including the protein, are not subsequently subjected to any evaporator; and
separating the oil from the water soluble solids portion to provide an oil portion after subjecting the separated water soluble solids portion to evaporation via an evaporator.

US Pat. No. 10,190,075

ENRICHMENT OF PALMITOLEIC ACID AND PALMITOLEIC ACID DERIVATIVES BY DRY AND SOLVENT-AIDED WINTERIZATION

OMEGA PROTEIN CORPORATION...

1. A method for producing an oil composition of a liquid olein fraction that is not derived from algae, wherein the oil composition comprises a mixture of not more than 0.2% (wt %) palmitic acid and at least 59% (wt %) palmitoleic acid from said liquid olein fraction, said method comprising fractional crystallization of a starting oil mixture containing more than 0.2% (wt %) palmitic acid and less than 59% (wt %) palmitoleic acid to produce the liquid olein fraction and a solid stearin fraction, and wherein said fractional crystallization comprises:(a) incubating a solution of said starting oil mixture in an organic solvent at a ratio of organic solvent to starting oil mixture at a temperature between about ?20° C. to about ?70° C. to produce said solid stearin fraction and said liquid olein fraction, wherein said organic solvent is selected from methanol, ethanol, isopropyl alcohol, acetone, and hexane, and wherein the ratio of methanol to the starting oil mixture is 2:1 to 1:1, the ratio of ethanol to the starting oil mixture is 2:1 to 1:1, the ratio of isopropyl alcohol to the starting oil mixture is 1:4 to 1:6, and the ratio of acetone to the starting oil mixture is 1:6 to 1:8, or the ratio of hexane to the starting oil mixture is 1:8 to 1:10;
(b) separating said solid stearin fraction and said liquid olein fraction; and
(c) collecting said liquid olein fraction to produce the oil composition of said liquid olein fraction.

US Pat. No. 10,190,073

LIPID COMPRISING LONG CHAIN POLYUNSATURATED FATTY ACIDS

COMMONWEALTH SCIENTIFIC A...

1. A process for producing extracted plant lipid, comprising the steps of:i) obtaining a Brassica sp. seed comprising extractable lipid having a total fatty acid content comprising fatty acids in an esterified form, the fatty acids comprising oleic acid, palmitic acid, ?6 fatty acids which comprise linoleic acid (LA), ?3 fatty acids which comprise ?-linolenic acid (ALA), stearidonic acid (SDA), docosapentaenoic acid (DPA) and docosahexaenoic acid (DHA), and optionally one or more of eicosapentaenoic acid (EPA) and eicosatetraenoic acid (ETA), wherein (a) the level of palmitic acid in the total fatty acid content of the extractable lipid is between about 2% and 16%, (b) the level of myristic acid (C14:0) in the total fatty acid content of the extractable lipid is less than 1%, and (c) the level of DHA in the total fatty acid content of extractable lipid in the plant part is between 20.1% and 30%, and
ii) extracting lipid from the Brassica sp. seed to thereby produce extracted plant lipid.

US Pat. No. 10,190,069

LUBRICATING COMPOSITION CONTAINING A THIOCARBAMATE COMPOUND

The Lubrizol Corporation,...

1. A lubricating composition comprising an oil of lubricating viscosity and 0.01 wt % to 5 wt % of an ashless sulfur containing compound comprising a thiocarbamate compound having an optionally-substituted hydrocarbyl group on an S-atom and an optionally-substituted hydrocarbyl group on an N-atom,wherein the ashless thiocarbamate compound having an optionally-substituted hydrocarbyl group on an S-atom and an optionally-substituted hydrocarbyl group on an N-atom is represented by the formula (4):
whereinY is S;R2 is a hydrocarbyl group consisting of 6 to 20 carbon atoms;R3 is a hydrocarbylene group; andR4 is a hydrocarbyl group consisting of 6 to 20 carbon atoms.

US Pat. No. 10,190,068

GIANT ELECTRORHEOLOGICAL FLUID SURFACTANT ADDITIVES

THE HONG KONG UNIVERSITY ...

1. A method for preparing giant electrorheological (GER) fluids, comprising the steps of:grinding a nanoparticle composite comprising urea and 0.2-5.0 wt % sodium dodecylbenzenesulfate (SDBS);
agitating the ground composite via ultrasonification for at least 30 minutes at 20-40° C.;
drying the composite for at least 12 hours in a freeze drying machine; and
suspending the composite in a non-conducting oil.

US Pat. No. 10,190,067

HIGH PERFORMANCE ENVIRONMENTALLY ACCEPTABLE HYDRAULIC FLUID

Washington State Universi...

1. A hydraulic fluid, comprising:one or more of a hydraulic environmental ester synthetic (HEES) and a hydraulic environmental triglyceride (HETG) at 10% to 85% by weight of the hydraulic fluid, wherein the one or more of HEES and HETG are or include natural and/or synthetic esters of at least one of vegetable-based and animal-based oils which are oleates;
a polyalphaolefin (PAO) at 1% to 40% by weight of the hydraulic fluid;
a polyalkylene glycol (PAG) at 1% to 40% by weight of the hydraulic fluid, wherein a ratio of PAO/PAG ranges from 0.2 to 5.

US Pat. No. 10,190,066

METHOD AND SYSTEM FOR BIOMASS HYDROGASIFICATION

G4 Insights Inc., Burnab...

1. A method, comprising:pyrolyzing biomass to produce a pyrolysis gas and char;
hydrogasifying the pyrolysis gas in the presence of a catalyst and hydrogen produced by a hydrogen generator powered by a renewable energy source, to produce a gas mixture;
separating the gas mixture into a substitute natural gas stream and a residual gas stream.

US Pat. No. 10,190,065

FEED DELIVERY SYSTEM AND METHOD FOR GASIFIER

1. A system for processing material for a gasifier, said system comprising:a first auger feeder adapted to receive and process material to be gasified;
an inclined conveyor adapted to receive said material processed by said first auger feeder, said conveyor adapted to transfer said material;
a second auger feeder positioned above said first auger feeder and adapted to receive said material transferred by said conveyor, said second auger feeder adapted to feed said material;
a tube connected to said second auger feeder such that said tube is adapted to receive said material from said second auger feeder, said tube comprising:
i) a body connected to said second auger feeder, said body having an inner wall that defines an opening adapted to receive said material from said second auger feeder such that said body is adapted to allow a flow of said material through said opening and out of said tube to said gasifier; and
ii) at least one restrictor that extends inwardly from said inner wall of said body into said opening, said at least one restrictor adapted to extend into said flow of said material to impede said flow, said at least one restrictor configured to enable said flow to flow around said at least one restrictor to exit out of said tube, wherein each said restrictor is adjustable such that a respective position of each said restrictor is adapted to be adjusted relative to said inner wall; and
a gasifier connected to said tube such that said gasifier is adapted to receive said material from said tube.

US Pat. No. 10,190,064

INTEGRATED PROCESS FOR SIMULTANEOUS REMOVAL AND VALUE ADDITION TO THE SULFUR AND AROMATICS COMPOUNDS OF GAS OIL

1. An integrated process for simultaneous removal and value addition to sulfur and aromatics compounds of a gas oil comprising:(i) distilling a gas oil under vacuum or positive pressure in the range of 40-2280 mm Hg and a temperature in the range 100-350° C. to obtain a refractive sulfur and polyaromatics lean lighter fraction of gas oil (LFGO), and a refractive sulfur and polyaromatics rich heavy fraction (HFGO) of gas oil;
(ii) mixing the HFGO obtained in step (i) with a polar solvent in a continuous extraction column at a temperature in the range of 30 to 70° C. with a solvent to feed ratio in the range of 0.5 to 4.0 to obtain a raffinate lean in refractive sulfur and polyaromatics and an extract rich in refractive sulfur and polyaromatics compounds;
(iii) washing the raffinate obtained in step (ii) with water generating water containing a small amount of solvent and a solvent free raffinate;
(iv) mixing the extract obtained in step (ii) with an anti-solvent in a single stage mixture settler, to obtain a pseudo raffinate (PSR) hydrocarbon and a solvent rich extract containing an enhanced concentration of sulfur and aromatic compounds;
(v) subjecting the solvent rich extract obtained in step (iv) and the water containing a small amount of solvent obtained from wash zones obtained in step (iii) to a solvent recovery column for recovery of an aqueous solvent and an extract hydrocarbon stream;
(vi) distilling the aqueous solvent obtained in step (v) to separate water and dry solvent with a water concentration in the range of 0.0 to 10.0% for its reuse in the process;
(vii) subjecting a fraction of the pseudo raffinate (PSR) hydrocarbon obtained in step (iv) in the range of 5% to 50% to a continuous extraction column;
(viii) subjecting a portion of the pseudo raffinate (PSR) hydrcarbon obtained in step (iv) in the range of 50% to 95% to a hydrocracker to obtain a gas oil of reduced sulfur and aromatics level, wherein the gas oil has sulfur less than 10 ppmw;
(ix) routing the extract hydrocarbon stream obtained in step (v) as a feed stock to carbon black generation unit to produce carbon or delayed coker unit to obtain reduced sulfur products;
(x) hydrotreating the refractive sulfur and polyaromatics lean lighter fraction of gas oil (LFGO) obtained in step (i), the solvent free raffinate as obtained in step (iii), or a mixture of the LFGO and the solvent free raffinate in the presence of hydrogen and metallic catalyst to produce a desulfurized gas oil having sulfur less than 75 ppmw; and
(xi) blending of the desulfurized gas oil having sulfur less than 75 ppmw obtained in step (x) with the gas oil having sulfur less than 10 ppmw obtained in step (viii) to produce a blended low sulfur gas oil wherein the sulfur in the blended low sulfur gas oil is less than 70 ppmw.

US Pat. No. 10,190,063

PRODUCTION OF OILFIELD HYDROCARBONS

Sasol Technology Propriet...

1. A process to produce olefinic products in the carbon range C16-C30 suitable for use as or conversion to oilfield hydrocarbons, the process comprising:separating an olefins-containing Fischer-Tropsch condensate into a light fraction which is a C5-C7 fraction, an intermediate fraction which is a C8-C15 fraction which includes paraffins and alpha-olefins and a heavy fraction which is a C16-C22 fraction which includes paraffins and alpha-olefins;
oligomerising at least a portion of the light fraction using a zeolitic catalyst to produce a first olefinic product which includes branched internal olefins;
carrying out either one or both of the steps of:
(i) dehydrogenating at least a portion of the intermediate fraction to convert the paraffins to internal olefins thereby to produce an intermediate product which includes internal olefins and alpha-olefins, and synthesising higher olefins, by means of dimerisation or olefin metathesis, from the intermediate product which includes internal olefins and alpha-olefins to produce a second olefinic product; and
(ii) dimerising at least a portion of the intermediate fraction to produce a second olefinic product; and
dehydrogenating at least a portion of the heavy fraction to convert the paraffins to internal olefins thereby to produce a third olefinic product which includes internal olefins,
the first olefinic product and the second olefinic product being such that a combination of the first olefinic product and the second olefinic product provides an olefinic product with at least 50% by mass of hydrocarbons having carbon chain lengths of between 15 and 30 carbon atoms per molecule.

US Pat. No. 10,190,062

BITUMEN PROCESSING AND TRANSPORT

CENOVUS ENERGY INC., Cal...

1. A method for preparing or converting bitumen for transport, the method comprising:separating asphaltene from the bitumen to generate a deasphalted oil and asphaltene;
separating the asphaltene into a first asphaltene fraction and a second asphaltene fraction, the first asphaltene fraction being less soluble in deasphalted oil and the second asphaltene fraction being more soluble in deasphalted oil; and
forming an asphaltene prill comprising an inner core comprising the second asphaltene fraction and an outer layer comprising the first asphaltene fraction.

US Pat. No. 10,190,060

PROCESS FOR INCREASING PROCESS FURNACES ENERGY EFFICIENCY

SAUDI BASIC INDUSTRIES CO...

1. A process for increasing process furnaces energy efficiency through gas turbine integration by using turbine exhaust gas, wherein a hydrocarbon feed is heated in a furnace, said process comprising the following steps:i) feeding furnace combustion air to burners of said furnace together with furnace fuel to provide high temperature heat to said furnace;
ii) cooling the hydrocarbon feed thus processed by using water from a steam drum under the formation of water vapour from some of the water;
iii) returning the mixture of water and water vapour thus formed to said steam drum;
iv) withdrawing saturated high-pressure steam from said steam drum and feeding said saturated high-pressure steam to a heat recovery unit; and
v) feeding said turbine exhaust gas to said heat recovery unit for converting said high-pressure steam into super heated high pressure steam, thereby decoupling the gas turbine from the process furnace.

US Pat. No. 10,190,059

PROCESS FOR THE HYDROTREATMENT OF RENEWABLE MATERIALS, WITH AN OPTIMIZED GAS RECYCLE

IFP Energies Nouvelles, ...

1. A process for the hydrotreatment of a feed obtained from renewable sources to produce paraffinic hydrocarbons which is carried out in the presence of hydrogen in a fixed bed reactor having a plurality of catalytic zones disposed in series and each catalytic zone comprising at least one hydrotreatment catalyst, said process comprising:a) dividing a liquid feed stream F into a plurality of different part-streams of liquid feed, F1 to Fn, respectively, wherein the number of part-streams of liquid feed is equal to the number of catalytic zones n in said fixed bed reactor, Z1 to Zn, respectively, and n is a whole number in the range of 2 to 10;
b) injecting a first part-stream of liquid feed F1 into a first catalytic zone Z1, and injecting a second part-stream of liquid feed F2 into a second catalytic zone Z2 and so on if n is greater than 2;
c) hydrotreating each part-stream, F1 to Fn, in each catalytic zone, Z1 to Zn, respectively, in the presence of hydrogen at a temperature in the range of 180° C. to 400° C., at a pressure in the range of 0.1 MPa to 15 MPa, at an hourly space velocity in the range of 0.1 h?1 to 10 h?1, and with a ratio of flow rate of hydrogen to flow rate of liquid feed in the range of 150 to 1500 Nm3/m3 to produce at least one effluent containing paraffinic hydrocarbons discharged from said reactor, wherein the mass flow rate of hydrogen sent to the first catalytic zone Z1 represents more than 80% by weight of the total mass flow rate of hydrogen used in the hydrotreatment process, hydrotreated product and hydrogen-containing gas are discharged from each catalytic zone, and, except for the nth catalytic zone, the hydrotreated product and hydrogen-containing gas from each catalytic zone are introduced into the next catalytic zone in the series, and the hydrotreated product and hydrogen-containing gas from the nth catalytic zone form said at least one effluent discharged from said reactor;
d) separating said effluent from c) in at least one separation step in order to separate at least one gaseous fraction containing hydrogen and at least one liquid fraction containing paraffinic hydrocarbons;
e) dividing at least a portion of said at least one liquid fraction containing paraffinic hydrocarbons from d) into a plurality of liquid recycle streams, RL1 to RLn, and recycling a first liquid recycle stream RL1 to the first catalytic zone Z1, and recycling a second liquid recycle stream RL2 to the second catalytic zone Z2 and so on if n is greater than 2; and
f) optionally dividing at least a portion of said gaseous fraction containing hydrogen from d) into a plurality of gaseous recycle streams, RG1 to RGn, and optionally recycling a first gaseous recycle stream RG1 to the first catalytic zone Z1, and optionally recycling a second gaseous recycle stream RG2 to the second catalytic zone Z2 and so on if n is greater than 2;
wherein each of the catalytic zones has a local recycle ratio which is defined as the weight ratio between (i) the total weight of the liquid recycle stream introduced to the catalytic zone plus any the liquid recycle streams introduced into any previous catalytic zone in the series, if present, and (ii) the part-stream of liquid feed introduced into the catalytic zone, and wherein said local recycle ratio of each catalytic zone is >0 to 2;
wherein the first catalytic zone of the series receives a liquid diluting stream and optionally a gaseous diluting stream, wherein the optional gaseous diluting stream is the first gaseous recycle stream from f);
wherein each of the other catalytic zones, Z2 to Zn, in the series receives liquid and gaseous diluting streams, wherein said liquid diluting streams are: (1) the part-stream(s) of liquid feed streams introduced into each of the previous catalytic zones in the series, if present, (2) the liquid recycle streams from e) introduced into each of the previous catalytic zones in the series, if present, and (3) the liquid recycle stream from e) introduced into the catalytic zone, and said gaseous diluting streams are: (4) the hydrogen-containing gas discharged from the previous catalytic zone in the series, if present, (5) the optional gaseous recycle streams from f) introduced into each of the previous catalytic zones in the series, if present, and (6) the optional gaseous recycle stream from f) introduced into the catalytic zone; and
wherein each of the catalytic zones has a local dilution ratio defined as the weight ratio between (I) the total quantity of liquid and gaseous diluting streams introduced into the catalytic zone and (II) the part-stream of liquid feed introduced into the catalytic zone, and wherein said local dilution ratio of each catalytic zone is >0 to less than 4.

US Pat. No. 10,190,058

HIGH-YIELD PRODUCTION OF FUELS AND PETRO- AND OLEO-CHEMICAL PRECURSORS FROM VEGETABLE OILS AND OTHER LIQUID FEEDSTOCKS IN A CONTINUOUS-FLOW PYROLYSIS REACTOR WITH OR WITHOUT CATALYSTS

The University of Toledo,...

1. A method of conducting a pyrolysis, the method comprising:atomizing an oil feedstock to produce atomized oil droplets, wherein the oil feedstock comprises vegetable oil, biooil, or biocrude;
pyrolyzing the atomized oil droplets in a reactor with or without a catalyst to produce pyrolysis products, wherein the pyrolysis is conducted at a temperature ranging from about 400° C. to about 600° C.; and
optionally, reacting the pyrolysis products in-situ with one or more added reactants to produce reacted pyrolysis products.

US Pat. No. 10,190,057

FISCHER-TROPSCH SYNTHESIS

SASOL TECHNOLOGY PROPRIET...

1. A method of synthesising Fischer-Tropsch products, the method includingfeeding a synthesis gas to a moving-bed Fischer-Tropsch synthesis reactor containing a Fischer-Tropsch catalyst in a moving catalyst bed, catalytically converting at least a portion of the synthesis gas in the moving catalyst bed to Fischer-Tropsch products and withdrawing the Fischer-Tropsch products from the moving-bed Fischer-Tropsch synthesis reactor,
the method further including, while the moving-bed Fisher-Tropsch synthesis reactor is on-line:
withdrawing a portion of the Fischer-Tropsch catalyst from the moving-bed Fischer-Tropsch synthesis reactor;
discarding from about 15 wt % to about 60 wt % of the withdrawn Fischer-Tropsch catalyst;
adding a reactivated Fischer-Tropsch catalyst to the moving-bed Fischer-Tropsch synthesis reactor; and
adding a fresh Fischer-Tropsch catalyst, in addition to the reactivated catalyst, to the moving-bed Fischer-Tropsch synthesis reactor.

US Pat. No. 10,190,055

REVERSE EMULSION BREAKER COPOLYMERS

Ecolab USA Inc., St. Pau...

1. A method of resolving a reverse emulsion in produced fluid of an oil production system comprising adding a reverse emulsion breaker to a produced fluid of the oil production system in an amount effective for resolving the reverse emulsion, the reverse emulsion breaker comprising a structured copolymer derived from the monomers of Formulae 1, 2, and 3:whereinR1, R2, and R3 are independently hydrogen or alkyl;
R4, R5, R6, R7, and R8 are independently alkyl;
A is independently —NH— or —O—;
p and q are independently an integer from 1 to 6; and
the weight average molecular weight of the structured copolymer is from about 20,000 to about 2,000,000 Daltons.

US Pat. No. 10,190,054

SYSTEM AND PROCESS FOR CONVERTING WHOLE TIRES AND OTHER SOLID CARBON MATERIALS INTO RECLAIMABLE AND REUSEABLE COMPONENTS

1. A method of converting carbon based material comprising the steps of:providing a rotatable chamber in which the material can be heated;
introducing the material into the chamber;
indirectly heating the chamber;
rotating the heated chamber with the material in the heated chamber to reduce the material;
collecting gases or oil or both from the reduced material from the chamber; and
collecting residual solids from the reduced material from the chamber;
wherein the chamber is heated to a temperature between about 350° F. and about 1100° F.;
wherein the carbon based material is rubber belting, a rubber construction track, a tire in the range of 4 inches in diameter to 120 inches in diameter, or a combination thereof, and wherein the material is introduced into the chamber without shredding, cutting or comminuting the material.

US Pat. No. 10,190,053

PYROLYSIS OF LIGNIN

Iowa State University Res...

1. A method of fast pyrolysis, said method comprising:(a) providing a technical lignin;
(b) treating the technical lignin with an alkali metal hydroxide or an alkaline earth metal hydroxide in an amount of from over 4% (w/w) to 20% (w/w) under conditions effective to reduce agglomeration, during pyrolysis, compared to when the technical lignin is not subjected to said treating; and
(c) pyrolyzing the treated technical lignin in continuous mode for 1 to 3 hours to produce pyrolysis products.

US Pat. No. 10,190,052

DEVICE AND METHOD FOR REGULATING AND CONTROLLING THE GAS PRESSURE

1. A device for regulating or controlling an individual gas pressure of each individual oven of a coke oven battery, the device comprising:a rising-pipe bend;
a water seal;
an immersion cup;
an actuator;
an immersion pipe that extends above the immersion cup and that is associated with a lower end of the rising-pipe bend via the water seal, the immersion pipe being supported such that it is vertically adjustable by means of the actuator so that the immersion pipe is immersible to different depths into the immersion cup for causing a change in pressure; and
a sleeve arranged in the rising-pipe bend which serves to position the immersion pipe, wherein a lower end of the sleeve is connected via at least one conduit to the water seal, and wherein a water supply, for feeding the water seal, and the actuator are provided at an upper end of the sleeve, outside the rising-pipe bend.

US Pat. No. 10,190,050

LIQUID CRYSTAL COMPOSITION, LIQUID CRYSTAL DISPLAY DEVICE INCLUDING THE SAME, AND METHOD OF MANUFACTURING LIQUID CRYSTAL DISPLAY DEVICE

SAMSUNG DISPLAY CO., LTD....

1. A liquid crystal composition, comprising:a liquid crystal compound; and
a liquid crystal aligning agent comprising at least one compound represented by Formula 1:

wherein in Formula 1,
X—* is a C1-20-alkyl-*,

-L1-* is a single bond, *—(CH2)p1—*, *—O(CH2)p1—*, *—O—*,
*—CH?CH—*, or *—C?C—*, wherein p1 is an integer of 1 to 10;-L2-* is a single bond, *—(CH2)p2—*, *—O(CH2)p2—*, *—O—*,
*—CH?CH—*, or *—C?C—*, wherein p2 is an integer of 1 to 10;-L3-* is a single bond, *—(CH2)p3—*, *—O(CH2)p3—*, *—O—*,
*—CH?CH—*, or *—C?C—*, wherein p3 is an integer of 1 to 10;*-L1-*, *-L2-*, and *-L3-* are identical to or different from one another;
*—C—* is a substituted or unsubstituted cyclic linking group, which is substituted or unsubstituted
substituted or unsubstitutedsubstituted or unsubstitutedsubstituted or unsubstitutedsubstituted or unsubstitutedsubstituted or unsubstitutedsubstituted or unsubstitutedsubstituted or unsubstitutedsubstituted or unsubstitutedsubstituted or unsubstitutedsubstituted or unsubstitutedsubstituted or unsubstitutedsubstituted or unsubstitutedsubstituted or unsubstitutedsubstituted or unsubstitutedsubstituted or unsubstitutedsubstituted or unsubstitutedsubstituted or unsubstitutedsubstituted or unsubstitutedsubstituted or unsubstitutedsubstituted or unsubstitutedor substituted or unsubstitutedwherein at least one hydrogen in the substituted cyclic linking group is substituted with a C1-10-alkyl-*, F—*, Br—*, I—*, *—OH, *—NH2, or a C1-10-((meth)acryloxy)alkyl-*;*—R—* is *—(CH2)q—*, *—O(CH2)q—*, *—(CH2)qArn-*, or *—O(CH2)qArn-*, wherein Arn is a substituted or unsubstituted C6-30 arylene and q is an integer of 1 to 10, wherein at least one hydrogen in the substituted C6-30 arylene is substituted with a C1-10-alkyl-*, F—*, Br—*, I—*, *—OH, *—NH2, or a C1-10-((meth)acryloxy)alkyl-*;
*—Y is
wherein n is an integer of 0 to 5;n1 is an integer of 1 to 3,
n2 and m are each independently 0 or 1, and
“*” indicates a point of attachment.

US Pat. No. 10,190,049

MESOGENIC MEDIA AND LIQUID CRYSTAL DISPLAY

MERCK PATENT GMBH, Darms...

1. Medium comprising one or more bimesogenic compounds, one or more nematogenic compound, one or more chiral compound and one or more compounds of formula I,R11-A11-(Z12-A12)m-AG  I
in which,
A11 and A12 each, independently of one another, denote an aryl-, heteroaryl-, heterocyclic- or alicyclic group optionally being substituted by one or more identical or different groups L,
L in each case, independently of one another, denotes, halogen, —CN, —NO2, —NCO, —NCS, —OCN, —SCN, straight-chain or branched alkyl or alkoxy having 1 to 5 C atoms, where, in addition, one or more non-terminal CH2 groups in these radicals may each be replaced, independently of one another, by —C?C—, —CF2O—, —CH?CH—,
—O—, —CO—O—, —O—CO— in such a way that O atoms are not linked directly to one another, and in which, in addition, one or more H atoms may be replaced by halogen,Z12 in each case, independently of one another, denotes
—O—, —S—, —CO—, —COO—, —OCO—, —S—CO—, —CO—S—, —O—COO—, —CO—NR0—, —NR0-CO—, —NR0-CO—NR00, —NR0-CO—O—,
—O—CO—NR0—, —OCH2—, —CH2O—, —SCH2—, —CH2S—, —CF2O—, —OCF2—, —CF2S—, —SCF2—, —CH2CH2—, —(CH2)4—, —CF2CH2—, —CH2CF2—, —CF2CF2—, —CH?N—, —N?CH—, —N?N—,
—CH?CR0—, —CY01?CY02—, —C?C—, —CH?CH—COO—,
—OCO—CH?CH—, or a single bond,
Y01 and Y02 each, independently of one another, denote H, F, Cl or CN,
R0 and R00 each, independently of one another, denote H or alkyl having 1 to 12 C atoms,
R11 denotes an alkyl or alkoxy radical having 1 to 15 C atoms, where, in addition, one or more non-terminal CH2 groups in these radicals may each be replaced, independently of one another, by —C?C—, —CF2O—, —CH?CH—,

 —O—, —CO—O—, —O—CO— in such a way that O atoms are not linked directly to one another, and in which, in addition, one or more H atoms may be replaced by halogen,
AG denotes -Sp-X11,
Sp denotes —(CH2)—,
p denotes 0, 1 or 2,
X11 denotes a group —NH2, —SH, —OH, —(CO)OH or a group of the formulae
andm denotes 0, 1 or 2;wherein:the one or more bimesogenic compound is selected from the group of compounds of formulae A-I to A-III,

wherein
R1 and R12,
R21 and R22,
and R31 and R32 are each independently H, F, Cl, CN, NCS or a straight-chain or branched alkyl group with 1 to 25 C atoms which may be unsubstituted, mono- or polysubstituted by halogen or CN, it being also possible for one or more non-adjacent CH2 groups to be replaced, in each occurrence independently from one another, by —O—, —S—, —NH—, —N(CH3)—, —CO—, —COO—, —OCO—, —O—CO—O—, —S—CO—, —CO—S—, —CH?CH—, —CH?CF—, —CF?CF— or —C?C— in such a manner that oxygen atoms are not linked directly to one another,
MG11 and MG12,
MG21 and MG22, and
MG31 and MG32 are each independently a mesogenic group,
Sp1, Sp2 and Sp3 are each independently a spacer group comprising 5 to 40 C atoms, wherein one or more non-adjacent CH2 groups, with the exception of the CH2 groups of Sp1 linked to O-MG11 and/or O-MG12, of Sp2 linked to MG21 and/or MG22 and of Sp3 linked to X31 and X32, may also be replaced by —O—, —S—, —NH—, —N(CH3)—, —CO—, —O—CO—,
—S—CO—, —O—COO—, —CO—S—, —CO—O—,
—CH(halogen)-, —CH(CN)—, —CH?CH— or —C?C—, in such a way that no two O-atoms are adjacent to one another, no two —CH?CH— groups are adjacent to each other, and no two groups selected from —O—CO—, —S—CO—, —O—COO—, —CO—S—, —CO—O— and —CH?CH— are adjacent to each other, and
X31 and X32 are independently from one another a linking group selected from —CO—O—, —O—CO—, —CH?CH—,
—C?C— or —S—, and, alternatively, one of them may also be either —O— or a single bond, and, again alternatively, one of them may be —O— and the other one a single bond;
the one or more nematogenic compound is selected from the group of compounds of formulae B-I to B-III,

wherein
RB1, RB21,
RB22, RB31 and
RB32 are each independently H, F, Cl, CN, NCS or a straight-chain or branched alkyl group with 1 to 25 C atoms which may be unsubstituted, mono- or polysubstituted by halogen or CN, it being also possible for one or more non-adjacent CH2 groups to be replaced, in each occurrence independently from one another, by —O—, —S—, —NH—, —N(CH3)—, —CO—,
—COO—, —OCO—, —O—CO—O—, —S—CO—, —CO—S—, —CH?CH—, —CH?CF—, —CF?CF— or —C?C— in such a manner that oxygen atoms are not linked directly to one another,
XB1 is F, Cl, CN, NCS,
ZB1, ZB2 and
ZB3 are in each occurrence independently —CH2—CH2—,
—CO—O—, —O—CO—, —CF2-O—, —O— CF2—, —CH?CH— or a single bond,
are in each occurrence independently
alternatively one or more of
areandn is 1, 2 or 3; and
the one or more chiral compound is selected from the group of compounds of formulae C-I to C-III,

the latter ones including the respective (S,S) enantiomers,
and wherein
E and F are each independently 1,4-phenylene or trans-1,4-cyclohexylene,
v is 0 or 1,
Z0 is —COO—, —OCO—, —CH2CH2— or a single bond, and
R is alkyl, alkoxy or alkanoyl with 1 to 12 C atoms.

US Pat. No. 10,190,047

GREEN-EMITTING, GARNET-BASED PHOSPHORS IN GENERAL AND BACKLIGHTING APPLICATIONS

Intematix Corporation, F...

1. A white LED comprising:a radiation source configured to provide excitation radiation having a wavelength greater than about 280 nm;
at least one green-emitting, garnet-based phosphor, at least one said green emitting, garnet-based phosphor having the formula:
(Y,A)3(Al,B)5(O,C)12:Ce3+, where
A is at least one of Tb, Gd, Sm, La, Lu, Sr, Ca, and Mg, including combinations of those elements, and wherein the amount of substitution of those elements for Y ranges from about 0.1 to about 100 percent stoichiometrically;
B is at least one of Si, Ge, B, F, and Ga, including combinations, wherein B substitutes for Al in amounts ranging from about 0.1 to about 100 percent stoichiometrically; and
C is at least one of F, Cl, N, and S, including combinations, wherein C substitutes for oxygen in amounts ranging from about 0.1 to about 100 percent stoichiometrically.

US Pat. No. 10,190,043

COMPOSITIONS COMPRISING QUANTUM DOTS

Merck Patent GmbH, Darms...

1. An electroluminescent device comprising a light emitting layer consisting of one type of quantum dot and one type of organic emitter, wherein said organic emitter is a phosphorescent, non-conjugated polymeric compound that includes at least one unit comprising a host compound, and a metal complex, the metal selected from a transition, a rare earth, a lanthanide, or an actinide metal, and the concentration of the quantum dots in the composition is in a range from 0.1 to 20 wt %;wherein the quantum dot is selected from the group consisting of CdSe, CdS, CdTe, ZnSe, ZnS, ZnTe, alloys thereof, combinations thereof, core/shell structures thereof, and core multi-shell layered structures thereof, with a trioctylphosphine oxide coating the surface of the quantum dot;
wherein the one organic emitter is a phosphorescent, non-conjugated polymer that includes a repeat unit selected from formula (77) or (78)

 wherein X and Y are independently selected from H, F, an alkyl group with 1 to 40 carbon atoms, an alkenyl group with 2 to 40 carbon atoms, an alkynyl group with 2 to 40 carbon atoms, a substituted or unsubstituted aryl group with 6 to 40 carbon atoms, and a substituted or unsubstituted heteroaryl group, wherein the heteroaryl group has 5 to 25 ring members.

US Pat. No. 10,190,040

SELF-SUSPENDING PROPPANT FOR HYDRAULIC FRACTURING

STEP ENERGY SERVICES LTD....

1. A proppant composition comprising:a volume of water;
300-500 kg/m3 of a self-suspending proppant, including a plurality of proppant granules each with a hydrophilic polymer coating, the hydrophilic polymer coatings of the self-suspending proppant together defining a total polymer volume; and
100-800 kg/m3 of an untreated proppant,wherein there is a total proppant load including both the self-suspending proppant and the untreated proppant of 500-1000 kg/m3 in the composition and wherein a concentration of the self-suspending proppant in the water is sufficient (i) to reduce the water to an unabsorbed volume of less than 25% of the volume of water and (ii) to hydrate at least 75% of the total polymer volume.

US Pat. No. 10,190,038

METHOD OF USING SOPHOROLIPIDS IN WELL TREATMENT OPERATIONS

Baker Hughes, a GE Compan...

1. A method of enhancing recovery of a well treatment fluid from a well after subjecting the well to a well treatment operation with the well treatment fluid, the method comprising pumping into the well the well treatment fluid and then, after completion of the well treatment operation, recovering the well treatment fluid from the well, the well treatment fluid comprising at least one sophorolipidic compound selected from the group consisting of:

US Pat. No. 10,190,035

PHENOL-ALKOXYLATE CO-SOLVENT SURFACTANT COMPOSITION

Board of Regents, The Uni...

1. An aqueous composition comprising water, an anionic surfactant, an alkali agent, and a co-solvent having the formula:
wherein
R1 is independently hydrogen or unsubstituted C1-C4 alkyl;
R2 is independently hydrogen or unsubstituted C1-C2 alkyl; and
n is an integer from 1 to 30,
wherein the aqueous composition has a salinity of at least 5,000 ppm and a pH of from 9.5 to 12,
wherein the co-solvent is present in an amount of from 0.25% to 3% by weight, based on the weight of the aqueous composition, and
wherein the anionic surfactant consists essentially of one or more anionic surfactants that are not alcohol phosphate surfactants or phosphate alkyl ester surfactants.

US Pat. No. 10,190,034

NON-REDUCING STABILIZATION COMPLEXANT FOR ACIDIZING COMPOSITIONS AND ASSOCIATED METHODS

Halliburton Energy Servic...

1. A method of reducing viscosifying tendencies of crude oil in a subterranean formation comprising:combining an effective amount of a solid acid chelating agent and an aqueous acid solution to form a treatment fluid, wherein the solid acid chelating agent comprises N-phosphonomethyl iminodiacetic acid (PMIDA);
introducing the treatment fluid into the subterranean formation, wherein the subterranean formation has a bottomhole temperature in excess of 350° F.;
contacting the crude oil with the treatment fluid; and
preventing an increase in viscosity of the crude oil.

US Pat. No. 10,190,033

SALT-FREE FLUOROUS-INVERT EMULSION FLUID

Halliburton Energy Servic...

1. A method of treating a well comprising: providing a treatment fluid comprising:a fluorous oil external phase,
an internal phase comprising water and glycerol, wherein the glycerol is present in an amount of about 40% to about 80% by weight of the internal phase, and wherein the internal phase is salt and chloride free, and
a fluorous-based surfactant; and
introducing the treatment fluid into a wellbore.

US Pat. No. 10,190,030

TREATED GEOTHERMAL BRINE COMPOSITIONS WITH REDUCED CONCENTRATIONS OF SILICA, IRON AND LITHIUM

Alger Alternative Energy,...

1. A treated geothermal brine composition, the composition comprising a treated geothermal brine comprising lithium, silica, iron, and lead, and having a concentration of lithium of no more than 200 mg/kg, a concentration of silica of no more than 80 mg/kg, a concentration of iron of no more than 300 mg/kg, and a concentration of lead greater than 25 mg/kg, wherein the treated geothermal brine comprises recoverable amounts of one or more of metals selected from the group consisting of boron, cesium, and rubidium.

US Pat. No. 10,190,028

EPOXY TWO-PART FORMULATIONS

Dow Global Technologies L...

1. A resin composition for a two-part adhesive comprisinga) an epoxy compound having the formula
wherein each R? is independently hydrogen, methyl, ethyl, n-propyl or isopropyl;b) a polyurethane comprising an elastomeric portion including one or more soft segments selected from a polyether, a polybutadiene or polyester soft segment, the soft segment or segments each having a molecular weight of 1000 to 10,000 daltons, the polyurethane having an average of 2 to 4 isocyanate groups capped with a polyphenol;
c) a core shell rubber epoxy dispersion comprising core shell rubber particles having a rubbery core with a Tg of less than ?25° C. and a shell polymer polymerized from at least one lower alkyl methacrylate provided that up to 40% of the weight of the shell polymer can be formed from styrene, vinyl acetate, vinyl chloride, methyl acrylate, ethyl acrylate and butyl acrylate; wherein the core shell rubber particles are dispersed in an epoxy resin and
d) an alkyl diglycidyl ether comprising a linear C3-10 linear alkyl group that is glycidyl terminated.

US Pat. No. 10,190,025

ADHESIVE COMPOSITION FOR POLARIZING PLATE

Samsung SDI Co., Ltd., Y...

1. An adhesive composition for polarizing plates, comprising:100 parts by weight of a polymerizable component including about 50 parts by weight to about 90 parts by weight of an epoxy group-containing compound (A) and about 10 parts by weight to about 50 parts by weight of a (meth)acrylate monomer (B), based on 100 parts by weight of the polymerizable component;
about 1 part by weight to about 7 parts by weight of a photoacid generator (C); and
about 0.1 parts by weight to about 7 parts by weight of at least one of a photosensitizer and a photopolymerization initiator (D);
wherein, the epoxy group-containing compound (A) comprises about 50 parts by weight to about 95 parts by weight of an alicyclic epoxy group-containing compound (A1) and about 1 part by weight to about 50 parts by weight of an aromatic group- and epoxy group-containing compound (A2), based on 100 parts by weight of the epoxy group-containing compound (A), and
the alicyclic epoxy group-containing compound (A1) and the aromatic group- and epoxy group-containing compound (A2) have a weight ratio of about 3:1 to about 95:1,
wherein when peeled under conditions of a peeling angle of 90° and a peeling rate of 300 mm/min, a polarizer and a PET film bonded by a cured product of the adhesive composition has a peel strength of 3 N/25 mm or more, or the polarizer and a COP film bonded by the cured product of the adhesive composition has a peel strength of 2 N/25 mm or more.

US Pat. No. 10,190,021

FLOOR COATING COMPOSITIONS AND FLOORING MATERIAL

DEXERIALS AMERICA CORPORA...

1. A floor coating composition used for coating of a floor and comprising components (A) to (E) below as essential components:component (A): a bifunctional (meth)acrylate compound not having an alicyclic structure;
component (B1): a trifunctional or more urethane (meth)acrylate oligomer;
component (B2): a hexafunctional or more urethane (meth)acrylate oligomer other than the component (B1);
component (C): a melamine (meth)acrylate;
component (D): metal oxide nanoparticles; and
component (E): an active energy ray polymerization initiator,
wherein the amount of component (A) contained is more than 24 weight % and less than 50 weight %, the amount of component (B1) contained is more than 10 weight % and less than 35 weight %, the amount of component (B2) contained is not less than 10 weight % and not more than 15 weight %, and the amount of component (C) contained is not less than 10 weight % and less than 20 weight %, and
wherein component (E) contains a hydrogen abstraction photopolymerization initiator.

US Pat. No. 10,190,015

PASSIVATION LAYER COMPRISING A PHOTOCROSSLINKED FLUOROPOLYMER

THE CHEMOURS COMPANY FC, ...

1. A passivation layer comprising a layer of a photocrosslinked coating composition disposed on at least a portion of a substrate, wherein the coating composition consists essentially of:i) a photocrosslinkable fluoropolymer having repeat units comprising:
(a) a fluoroolefin;
(b) an alkyl vinyl ether wherein the alkyl group is a C1 to C6 straight or a C3 to C6 branched or cyclic saturated hydrocarbon radical; and
(c) a vinyl epoxide;
ii) a photoacid generator;
iii) an optional photosensitizer; and
iv) a carrier medium;
wherein the photocrosslinkable fluoropolymer has a number average molecular weight in the range of from 20,000 to 300,000, and, wherein the layer of photocrosslinked coating composition has a dielectric constant in the range of from 1 to 5 when measured at 100 kHz, and wherein the layer of the photocrosslinked coating composition having a thickness in the range of from 0.01 micrometers to 300 micrometers has photocrosslinked features having a minimum width that is the larger of a) about 10 percent the thickness of the coating composition or b) 0.5 micrometers.

US Pat. No. 10,190,010

INK, INK CARTRIDGE, AND IMAGE RECORDING METHOD

Canon Kabushiki Kaisha, ...

1. An ink comprising:a pigment;
a water-soluble organic solvent; and
a surfactant,
wherein the ink has a viscosity of 5 mPa·s or more at 25° C.,
wherein a static surface tension of the ink as measured at 25° C. using a Wilhelmy method is from 31.0 mN/m to 35.0 mN/m, and
wherein a dynamic surface tension of the ink as measured at 25° C. using a maximum bubble pressure method is from 30.5 mN/m to 37.0 mN/m when a bubble life time is 150 msec.

US Pat. No. 10,190,007

INK, INK CONTAINER, IMAGE FORMING METHOD, IMAGE FORMING APPARATUS, AND IMAGE FORMED MATTER

Ricoh Company, Ltd., Tok...

1. An ink, comprising:a colorant;
an organic solvent;
water; and
a surfactant comprising at least one polyether-modified siloxane compound selected from the group consisting of compounds of formulae (III), (IV), (V), and (VI),

where in the formula (III), m represents an integer in a range of from 0 through 23, n represents an integer in a range of from 1 through 10, a represents an integer in a range of from 1 through 23, b represents an integer in a range of from 0 through 23, and R represents a hydrogen atom or an alkyl group that comprises 1 through 4 carbon atoms,

where in the formula (IV), m represents an integer in a range of from 1 through 8, c and d represent an integer in a range of from 1 through 10, and R2 and R3 represent a hydrogen atom or an alkyl group that comprises 1 through 4 carbon atoms,

where in the formula (V), e represents an integer in a range of from 1 through 8 and R4 represents a hydrogen atom or an alkyl group that comprises 1 through 4 carbon atoms,

where in the formula (VI), f represents an integer in a range of from 1 through 8 and R5 represents a polyether group represented by the formula (A),

where in the general formula (A), g represents an integer in a range of from 0 through 23, h represents an integer in a range of from 0 through 23, where g and h do not take 0 at a same time, and R6 represents a hydrogen atom or an alkyl group that comprises 1 through 4 carbon atoms,
wherein the organic solvent comprises at least one organic solvent having a solubility parameter of greater than or equal to 9 but less than 11.8,
wherein a content of the organic solvent having a solubility parameter of greater than or equal to 9 but less than 11.8 is greater than or equal to 20% by mass of a total amount of the ink,
wherein a dynamic surface tension A of the ink at 25° C. at a surface lifetime, measured by a maximum foaming pressure method, of 15 msec is less than or equal to 34.0 mN/m, and
wherein the dynamic surface tension A and a static surface tension B of the ink at 25° C. satisfy a formula of 10.0%?[(A?B)/(A+B)]×100?19.0%.

US Pat. No. 10,190,004

PEELABLE COATING

Skudo Group Pty Ltd, Rob...

1. A method of applying a peelable and temporary protective coating to a floor during a construction phase of a commercial or residential premises, the method including the steps of:applying a liquid to the floor for forming a base layer, the base layer being peelable from the floor when dry; and
applying a pre-manufactured reinforcing layer atop the base layer while wet, and removing the base layer and reinforcing layer together after the phase.

US Pat. No. 10,189,998

DOPED NICKEL OXIDE INTERFACIAL LAYER

Hunt Energy Enterprises, ...

1. A photovoltaic device comprising:a first electrode;
a second electrode; and
an active layer disposed at least partially between the first and second electrodes, the active layer comprising: an NiO interfacial layer doped with copper that is adjacent to and in contact with a perovskite material photoactive layer.

US Pat. No. 10,189,996

ANTHRACENE-BASED ORGANIC DYE

NATIONAL CHI NAN UNIVERSI...

1. An anthracene-based organic dye represented by Formula (1):
wherein
s, m, and n represent independently 0 or 1;
Q is an anchoring group selected from the group consisting of

 wherein X1, X2, X3, X4, X5, X6, X7, and X8 are independently selected from the group consisting of hydrogen, lithium, sodium and

 wherein Z1, Z2, Z3, and Z4 represent independently a C1-C6 alkyl group;
P is an electron acceptor group selected from the group consisting of

 wherein T1, T2, T3, and T4 are independently selected from the group consisting of hydrogen, fluoro, a C4-C12 alkyl group, and a C4-C2 alkoxy group, and T5 is selected from the group consisting of hydrogen and a C4-C17 alkyl group; and
R is an electron donor group with the proviso that
R is selected from the group consisting of

 when s represents 1, and
R is selected from the group consisting of

 when s represents 0,
wherein
Y1, Y2, Y3, Y4, Y9, Y10, Y11, Y12, Y13, Y14, Y15, Y16, Y17, Y18, Y21, Y22, Y23, and Y24 are independently selected from the group consisting of hydrogen and a C4-C12 alkyl group, and
Y5, Y6, Y7, Y8, Y19, and Y20 are independently selected from the group consisting of hydrogen, fluoro, a C4-C12 alkyl group, and a C4-C12 alkoxy group.

US Pat. No. 10,189,986

ACRYLAMIDE-BASED COPOLYMERS, TERPOLYMERS, AND USE AS HYDRATE INHIBITORS

Saudi Arabian Oil Company...

1. A terpolymer having General Formula (I):
in which:
R1, R2, and R3 are each independently chosen from C1 to C8 saturated aliphatic groups,
R4 is chosen from divalent C4 to C7 linear aliphatic groups or divalent C4 to C7 linear heteroaliphatic groups, optionally substituted with one or more C1-C6 linear aliphatic groups, C1-C6 branched aliphatic groups, or combination thereof, where the divalent C4 to C7 linear heteroaliphatic groups comprise 1 or 2 heteroatoms independently chosen from O, N, or S,
R5, R6, and R7 are each independently chosen from methyl or hydrogen,
x is a molar fraction range chosen from greater than 0 to 0.8,
y is a molar fraction range chosen from greater than 0 to 0.8,
z is a molar fraction range chosen from 0.1 to 0.9, where the summation of x, y, and z equals 1, and
the terpolymer is random.

US Pat. No. 10,189,983

CURABLE RESIN COMPOSITION, RESIN MOLD FOR IMPRINTING, METHOD FOR PHOTO IMPRINTING, METHOD FOR MANUFACTURING SEMICONDUCTOR INTEGRATED CIRCUIT, AND METHOD FOR MANUFACTURING FINE OPTICAL ELEMENT

Toyo Gosei Co., Ltd., Ic...

1. A curable resin composition comprising:a fluorinated urethane(meth)acrylate represented by formula (1),

wherein:
each of R1, R2, R3 and R4 independently represents a hydrogen atom or a methyl group, x and y each independently represents 1 or 2, and n represents an integer within the range of 1 to 10;
each of R3 and R4 independently represents the hydrogen atom when x and y are both 1;
R3 represents the hydrogen atom and R4 represents the methyl group when x is 1 and y is 2;
R3 represents the methyl group and R4 represents the hydrogen atom when x is 2 and y is 1; and
each of R3 and R4 independently represents the methyl group when x and y are both 2.

US Pat. No. 10,189,982

CONTACTING COMPONENT AND STRUCTURE CONTAINING SAID CONTACTING COMPONENT

TECHNO POLYMER CO., LTD.,...

1. A contacting component comprising a molded article made from a thermoplastic resin composition (X) containing a vinyl graft polymer (A), a vinyl non-graft polymer (B) and a matting agent (C),wherein:
the vinyl graft polymer (A) contains an ethylene-?-olefin rubber polymer (a1).

US Pat. No. 10,189,978

RUBBER COMPOSITION COMPRISING A HIGHLY SATURATED DIENE ELASTOMER

COMPAGNIE GENERALE DES ET...

1. A rubber composition comprising a reinforcing filler and an elastomer matrix comprising a highly saturated diene elastomer,wherein the highly saturated diene elastomer comprises at least units of A, B, C, D and E, distributed randomly within the highly saturated diene elastomer:

wherein R1 and R2, which are identical or different, represent a hydrogen atom, a methyl radical or a phenyl radical, which is substituted or unsubstituted in the ortho, meta or para position by a methyl radical,
wherein (D) is a divalent hydrocarbon-based ring with 6 carbon atoms of 1,2-cyclohexane type,
wherein (E) is a divalent hydrocarbon-based ring with 6 carbon atoms of 1,4-cyclohexane type,
wherein m, n, o, p and q are numbers ranging from 0 to 100, and
wherein the highly saturated diene elastomer satisfies the following:
m+n+o+p+q=100,
m?50,
n+o+p+q?10, and
15?p+q?2.

US Pat. No. 10,189,975

CABLE FILL COMPOSITION

SHELL OIL COMPANY, Houst...

1. A cable fill composition for an optical fiber cable, said cable fill composition comprising (i) a Fischer-Tropsch derived base oil; and (ii) a thickening system, wherein the thickening system comprises at least one block copolymer.

US Pat. No. 10,189,970

METHOD FOR GRANULATING POLYMERS AND PRODUCT PRODUCED BY THIS METHOD

COMPAGNIE PLASTIC OMNIUM,...

1. A method for granulating polymers from ground post-consumer materials, wherein said method comprises a step of:extracting dissolved salts and/or small unmelted clusters present within said polymers;
wherein said extracting step comprises the step of adding a fluid or mixture of fluids in an extruder which solubilizes said dissolved salts and/or small unmelted clusters or entrains them, at least one of said dissolved salts and/or small unmelted clusters so extracted being evacuated under atmospheric pressure or under vacuum during extrusion before passing into an extrusion head;
wherein said fluid is at least one of water or a mixture containing water, introduced into said extruder at a pressure greater than that present in said extruder;
wherein 60 g of water or more is added per kg of extruded material; and
wherein said method further comprises a step of granulating said polymers after passing through a die of said extrusion head;
wherein said method is used to extrude a polymer that is used for molding a part, that, after coating, has a maximum in the appearance areas of visible parts of 4 faults of type grains, craters, or particles, per m2, of size greater than 50 ?m.

US Pat. No. 10,189,967

MACROPOROUS PHOTONIC CRYSTAL MEMBRANE, METHODS OF MAKING, AND METHODS OF USE

UNIVERSITY OF FLORIDA RES...

1. A structure comprising:a macroporous photonic crystal membrane including a three dimensional array of macropores, wherein a three dimensional polymer framework separates the macropores, wherein the polymer framework is made of a copolymer of two oligomers, wherein the two oligomers are ethoxylated (20) trimethylolpropane triacrylate (ETPTA 20) and polyethylene glycol (600) diacrylate (PEGDA 600), wherein when the macropores are in a collapsed state, the macroporous photonic crystal membrane is substantially transparent and wherein when the macropores are in an uncollapsed state, the macroporous photonic crystal membrane has an iridescent color.

US Pat. No. 10,189,962

HEAT-SHRINKABLE POLYESTER FILM

TOYOBO CO., LTD., Osaka ...

1. A heat-shrinkable polyester film comprising ethylene terephthalate as a main component, containing not less than 0 mol % and not more than 5 mol % of a monomer component capable of serving as an amorphous component relative to the total of a polyester resin component, and having a main shrinkage direction in a lengthwise direction, wherein the heat-shrinkable polyester film satisfies the following requirements (1) to (3):(1) the heat-shrinkable polyester film has a hot-water heat shrinkage rate in the lengthwise direction of not less than 15% and not more than 60% when being treated in hot water at 90° C. for 10 seconds;
(2) the heat-shrinkable polyester film has a hot-water heat shrinkage rate in a width direction orthogonal to the lengthwise direction of not less than ?10% and not more than 10% when being treated in hot water at 90° C. for 10 seconds; and
(3) the heat-shrinkable polyester film has an orientation distortion index that is a molecular orientation angle difference, the difference being a difference between a molecular orientation angle of an edge of one end in the width direction and a molecular orientation angle of an edge of the other end, per 1 m of the film of not more than 15°/m.

US Pat. No. 10,189,961

CREEP RESISTANT, HIGHLY LUBRICIOUS, TOUGH, AND IONIC HYDROGELS INCLUDING PVA-PAAMPS HYDROGELS

The General Hospital Corp...

1. A method of making a creep resistant, highly lubricious, tough and ionic hydrogel comprising:a) mixing an aqueous solution of a polymer with an aqueous solution of an ionic monomeric compound in presence of an initiator, thereby forming an ionic hydrogel solution, wherein the aqueous solution of the polymer comprises 1% w/w to 25% w/w of the polymer, and wherein the aqueous solution of the ionic monomeric compound comprises 5% w/w to 25% w/w of the ionic monomeric compound;
b) heating and/or irradiating the ionic hydrogel solution, thereby forming an inter-penetrating network (IPN) structure of polymerized ionic hydrogel in the aqueous polymer solution; and
c) subjecting the inter-penetrating network (IPN) structure of polymerized ionic hydrogel in the aqueous polymer solution to one or more freeze-thaw cycles to physically-crosslink the polymer, thereby forming a creep resistant, highly lubricious, tough and ionic hydrogel, and
d) annealing the ionic hydrogel,
wherein the polymer is poly(vinyl alcohol) (PVA), and the ionic monomeric compound is a acrylamido-methylpropane sulfonic acid (AAMPS) solution, and the inter-penetrating network (IPN) structure of polymerized ionic hydrogel is an inter-penetrating network (IPN) structure of polymerized PAAMPS, and the creep resistant, highly lubricious, tough and ionic hydrogel is a creep resistant, highly lubricious, tough and ionic PVA-PAAMPS-hydrogel.

US Pat. No. 10,189,958

ORGANIC POLYMERIC PARTICLES, PAPER COATING COMPOSITIONS AND METHODS

OMNOVA Solutions, Inc., ...

1. A coated paper comprising:a base paper having a first and a second surface; and
a paper coating composition applied to the first, the second, or both the first and second surfaces, where the paper coating composition comprises a binder and a hollow porous particle; and
where the hollow porous particle was prepared by a process that includes
(i) providing an organic polymeric particle including a core including a polymer including units deriving from the polymerization of acrylate monomer; and a shell surrounding the core, where the shell includes a polymer having units deriving from the polymerization of styrene monomer and acrylate monomer selected from methyl acrylate, butyl acrylate, and combinations thereof; where the shell includes polymer having from 70 to 98 weight units deriving from the polymerization of styrene monomer, and from 2 to 30 weight units deriving from the polymerization of acrylate monomer; and
(ii) subjecting the organic polymeric particle to conditions that will hydrolyze the units deriving from the polymerization of acrylate monomer within the shell and the core, to thereby provide a hollow porous particle.

US Pat. No. 10,189,955

NESTED SUPRAMOLECULAR CAPSULES

CAMBRIDGE ENTERPRISE LIMI...

1. A nested capsule comprising a first capsule held within a second capsule, and each of the first and second capsules has a shell that is a supramolecular cross-linked network, whereineach shell is obtainable from the complexation of a composition comprising a host and one or more building blocks having suitable guest functionality, thereby to form a supramolecular cross-linked network, wherein the second capsule is not provided as a layer on the surface of the first capsule, and the supramolecular cross-linked network includes a non-covalent complex of the host and the one or more building blocks having suitable guest functionality.

US Pat. No. 10,189,954

SYNTHESIS OF ANTIMICROBIAL SILSESQUIOXANE-SILICA HYBRIDS

Kimmerling Holdings Group...

1. A method of preparing a silsesquioxane-silica hybrid, comprising:hydrolytically co-condensing, in the presence of at least one (C1-C3)alcohol and a catalytic amount of an ammonium cation (NH4+), of a tetraalkoxysilane of formula I:
with a trialkoxysilane of formula II:and with a trialkoxysilane of formula III:wherein said compound of formula II, said compound of formula I, and said compound of formula III are reacted in a molar ratio of about 1:1-32:1, respectively; wherein:A1, A2, A3, and A4 are each independently selected from the group consisting of H, C1-C8alkyl, and trifluoro-substituted (C1-C8)alkyl;
Ra is independently a functional group comprising at least one curing group selected from the group consisting of acrylate, methacrylate, (C2-C8)alkenyl, glycidyloxy, epoxy, sulfonate, carboxylate, ester, amino, acrylamide, methacrylamide, isocyanato, amino acid, nucleic acid, and mercapto(C1-C6)alkyl;
Rb is independently

wherein:
Rc is (C1-C2)alkyl;
Rd is (C1-C2)alkyl or phenyl;
Re is (C6-C22)alkyl;
X?is an anion selected from the group consisting of chloride, bromide, fluoride, iodide, sulfonate, and acetate;
each RY is, independently, H, (C1-C8)alkyl, or trifluoro-substituted (C1-C8)alkyl.

US Pat. No. 10,189,948

ISATIN COPOLYMERS HAVING INTRINSIC MICROPOROSITY

Dow Global Technologies L...

1. A copolymer comprising a repeating unit represented by:wherein:Y is selected from: a carboxylic acid, sulfonic, phosphorous acid and phosphoric acid and their corresponding salt or ester, imino, amide; nitrile, hydrogen, hydroxyl and alkyl comprising from 1 to 6 carbon atoms; and
R1, R2, R3, and R4 are independently selected from: hydrogen, alkyl groups comprising from 1 to 6 carbon atoms, and R1 and R2 may collectively form a ketone group or a 9,9?-fluorene group, and R3 and R4 may collectively form a ketone group or a 9,9?-fluorene group;
R5 and R6 are independently selected from: a bond and an alkylene group comprising from 1 to 6 carbon atoms;
R7 is selected from: hydrogen, alkyl, aryl, aralkyl and heteroaryl groups comprising from 1 to 8 carbon atoms which may be unsubstituted or substituted with carboxylic acid, sulfonic acid and phosphoric acid and their corresponding salt or ester, imino and amide; and
X and X? are independently selected from: a carboxylic acid, sulfonic acid and phosphoric acid and their corresponding salt or ester, imino and amide; nitrile, hydrogen, alkyl having from 1 to 6 carbon atoms and alkoxy having from 1 to 6 carbon atoms.

US Pat. No. 10,189,947

COMPOSITION OF ANTI-REFLECTIVE HARDMASK

1. An anti-reflective hardmask composition comprising:(a) a carbazole derivative polymer represented by the following Formula 1 or a polymer blend comprising the carbazole derivative polymer; and
(b) an organic solvent:

where R1 is hydrogen or an aromatic ring selected from the group consisting of the following substituents, R2 is an aromatic ring selected from the group consisting of the following substituents, and R1 and R2 may be the same or different:

where X is at least one selected from the following substituents:

where Z is an integer of 0 or 1,
m/(m+n) equals to a value in the range of between 0.1 and 0.8, and
a weight average molecular weight (Mw) of the polymer is between 1,000 and 30,000.

US Pat. No. 10,189,946

PROCESS FOR PREPARING POLYAMINES

BASF SE, Ludwigshafen (D...

1. A process for preparing a polyamine,the process comprising polycondensing at least one diamine in liquid phase in the presence of hydrogen and at least one catalyst based on at least one metal of transition groups 8 to 11 of the Periodic Table of the Elements, by keeping pressure constant during the polycondensing through continuous supply of an inert gas, hydrogen, or both, and removing the inert gas, the hydrogen, or both, and ammonia formed during the polycondensing,
wherein:
the polycondensing occurs at a temperature of 150 to 180° C. and a pressure of 60 to 150 bar; and
a mean molecular weight of the polyamine is ?203 g/mol, in which a deviation from the mean molecular weight per ° C. of change in reaction temperature is <19% of the mean molecular weight.

US Pat. No. 10,189,928

CURABLE COMPOSITION, PATTERN FORMING METHOD, PATTERN, AND METHOD FOR MANUFACTURING DEVICE

FUJIFILM Corporation, To...

1. A curable composition comprising:a polymerizable compound; and
a photopolymerization initiator,
wherein neopentyl glycol diacrylate accounts for 10% by mass or more of the polymerizable compound, and
the total content of a compound represented by the following Formula (I) and a compound represented by the following Formula (II) is 5% by mass or less with respect to the content of neopentyl glycol diacrylate:

US Pat. No. 10,189,917

FLUORINATED CATALYST SUPPORTS AND CATALYST SYSTEMS

Univation Technologies, L...

1. A method for making a fluorinated catalyst support, comprising:forming a mixture of a support material and a first portion of a fluoride donor, where the support material is an inorganic oxide;
adding the mixture to a fluidized bed reactor;
fluidizing the mixture in the fluidized bed reactor with a fluidizing gas at a flow rate that forms a fluidized bed with a height to diameter ratio of at least about 2.3; and
calcining the mixture to decompose the fluoride donor and fluorinate the support material thereby forming a partially fluorided support, and
adding a second portion of the fluoride donor to the partially fluorided support;
calcining the second portion of the fluoride donor to the partially fluorided support to form the fluorinated catalyst support.

US Pat. No. 10,189,877

TETRAVALENT DENGUE VACCINE

International Centre for ...

1. A virus like particle (VLP) comprising:a) a recombinant polypeptide comprising an EDIII domain of each of Dengue virus serotypes DENV-1, DENV-2, DENV-3 and DENV-4, linked to N-terminal of an HBsAg polypeptide, as depicted below:
EDIII-1-EDIII-3-EDIII-4-EDIII-2-HBsAg;
wherein the dotted line is a linker; and
wherein the amino acid sequence of the EDIII domain of each of Dengue virus serotypes DENV-1, DENV-2, DENV-3 and DENV-4 is SEQ ID NO's 1, 2, 3 and respectively; and
b) 4 units of an HBsAg polypeptide.

US Pat. No. 10,189,870

CRYSTALLINE FORM OF OXAZOLIDINONE ANTIBIOTICS AND PREPARATION METHOD, COMPOSITION AND USE THEREOF

HANGZHOU PUSHAI PHARMAEUT...

1. Form II of (R)-3-(4-(2-(2-methyltetrazol-5-yl)pyridine-5-yl)-3-fluorophenyl)-5-hydroxymethyl oxazolidin-2-one dihydrogen phosphate represented by the following structural formula:
measured with Cu—K? radiation, the X-ray powder diffraction pattern of the Form II, expressed as 2? angles, has the following characteristic peaks: 10.5±0.2°, 15.7±0.2°, 16.5±0.2°, 17.3±0.2°, 21.0±0.2° and 26.3±0.2°.

US Pat. No. 10,189,866

LITHIUM SECONDARY BATTERY, ELECTROLYTE SOLUTION FOR LITHIUM SECONDARY BATTERY, AND ADDITIVE FOR ELECTROLYTE SOLUTION THEREFOR

HITACHI, LTD., Tokyo (JP...

1. A lithium secondary battery comprising:a positive electrode having a lithium-ion intercalation/de-intercalation ability;
a negative electrode having a lithium-ion intercalation/de-intercalation ability; and
a non-aqueous electrolyte solution contacted with the positive electrode and the negative electrode, wherein
the non-aqueous electrolyte solution contains lithium hexafluorophosphate and a boroxine compound liquefying at 25° C. selected from the group consisting of (O+CH2CH2CH2CH3)3(BO)3 and (O—CH(CH3)CH2CH3)3(BO)3.

US Pat. No. 10,189,865

GOLD(I) COMPLEXES, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS OF TREATING PROLIFERATIVE DISORDERS

King Fahd University of P...

1. A gold(I) complex of Formula (I)or a salt thereof, a solvate thereof, a tautomer thereof, a stereoisomer thereof, or a mixture thereof;wherein:
R1 and R2 are independently selected from the group consisting of a hydrogen, an optionally substituted alkyl, an optionally substituted cycloalkyl, and an optionally substituted arylalkyl;
R3, R4, R5, R6, and R7 are independently selected from the group consisting of a hydrogen, an optionally substituted alkyl, an optionally substituted alkenyl, an optionally substituted alkynyl, an optionally substituted cycloalkyl, an optionally substituted alkoxy, an optionally substituted aryl, an optionally substituted arylalkyl, an optionally substituted alkanoyl, an optionally substituted aroyl, a halogen, a cyano, and a nitro;
R8 and R9 are independently a hydrogen, or an optionally substituted alkyl; and
X is an anion.

US Pat. No. 10,189,862

PHENOTHIAZINE-PYRIDINE COMPOUNDS AND USES THEREOF

The Chinese University of...

15. A pharmaceutical composition comprising the compound of claim 1 and a pharmaceutically acceptable excipient.

US Pat. No. 10,189,854

SUBSTITUTED PYRIMIDINE COMPOUNDS

GRUENENTHAL GMBH, Aachen...

1. A method of treating a condition or disease which can be treated by inhibition of PDE4 enzyme in a subject, comprising administering to the subject a compound of formula (I)
wherein
A, B and C independently represent CH or N;
R1 and R2 independently represent
hydrogen or (C1-C6)-alkyl, whereby said (C1-C6)-alkyl is unsubstituted or substituted with at least one substituent X1, or
a group U, which is a 3- to 12-membered mono- or bi-cycloaliphatic ring, which is unsubstituted or substituted with at least one substituent X2, whereby said group U may be connected to the nitrogen atom via a C1-6-alkylene group, which in turn is unsubstituted or substituted with at least one substituent independently selected from the group consisting of F, Cl, CF3, ?O, OCF3 and OH, or
a group V, which is a 3- to 12-membered mono- or bi-cyclic heterocycloaliphatic ring comprising at least one heteroatom selected from the group consisting of O, S and N as a ring member, and which mono- or bicyclic heterocycloaliphatic ring is unsubstituted or substituted with at least one substituent X3, whereby said group V may be connected to the nitrogen atom via a C1-6-alkylene group, which in turn may be unsubstituted or substituted with at least one substituent independently selected from the group consisting of F, Cl, CF3, ?O, OCF3 and OH, or
a group W which is phenyl or 5- or 6-membered heteroaryl, wherein said phenyl or said heteroaryl is unsubstituted or substituted with at least one substituent X4 and may be condensed with a 4-, 5-, 6- or 7-membered ring, being carbocyclic or heterocyclic, wherein said condensed ring may be saturated, partially unsaturated or aromatic and may be substituted with at least on substituent X5, and whereby group W may be connected to the nitrogen atom via a C1-6-alkylene group, which in turn may be unsubstituted or substituted with at least one substituent independently selected from the group consisting of F, Cl, CF3, ?O, OCF3 and OH, or
R1 and R2 together with the nitrogen atom to which they are attached form a 3- to 12-membered monocyclic or bicyclic non-aromatic or aromatic ring wherein said ring may contain at least one additional heteroatom selected from the group consisting of O, S and N and wherein said ring is unsubstituted or substituted with at least one substituent X6;
R3 and R4,
independently represent hydrogen, (C1-C6)-alkyl or (C3-C6)-cycloalkyl, wherein said (C1-C6)-alkyl and (C3-C6)-cycloalkyl are each unsubstituted or substituted with at least one substituent Y1, or
together with the carbon atom to which they are attached form a 3- to 6-membered cycloalkyl ring, which is unsubstituted or substituted with at least one substituent Y2;
L represents a bond, O, S, (C1-C6)-alkylene or (C2-C6)-alkenylene, whereby the aforementioned alkylenes or alkenylenes are in each case unsubstituted or substituted with at least one substituent selected from the group consisting of F, Cl, CF3, ?O, OCF3 and OH;
G represents a phenyl or 5- or 6-membered heteroaryl, wherein said phenyl or said heteroaryl may be substituted with at least one substituent Z;
X1, X2, X3, X5 and X6, at each occurrence are independently from one another selected from the group consisting of OH, ?O, CN, nitro, halogen, (C1-C6)-alkyl, (C1-C6)-hydroxyalkyl, (C1-C6)-alkoxy, S(C1-C6)-alkyl, S(O)—(C1-C6)-alkyl, S(O)2—(C1-C6)-alkyl, (C1-C6)-haloalkyl, S(C1-C6)-haloalkyl, (C1-C6)-haloalkoxy, (C1-C6)-cyanoalkyl, (C3-C8)-cycloalkyl, NH2, NH(C1-C6)-alkyl, N((C1-C6)-alkyl)2, NH—CO—(C1-C6)-alkyl, NH—SO—(C1-C6)-alkyl, NH—S(O)2—(C1-C6)-alkyl, NH((C1-C6)-alkylen)-SO—(C1-C6)-alkyl, NH((C1-C6)-alkylen)-SO2—(C1-C6)-alkyl, NHCONH2, NH—CO—NH—(C1-C6)-alkyl, NH((C1-C6)-alkylen)-CO—N((C1-C6)-alkyl)2, CO—(C1-C6)-alkyl, CO2H, CO—O—(C1-C6)-alkyl, CONH2, CO—NH(C1-C6)alkyl and CO—N((C1-C6)-alkyl)2;
X4 at each occurrence are independently from one another selected from the group consisting of OH, CN, nitro, halogen, (C1-C6)-alkyl, (C1-C6)-hydroxyalkyl, (C1-C6)-alkoxy, S(C1-C6)-alkyl, S(O)—(C1-C6)-alkyl, S(O)2—(C1-C6)-alkyl, (C1-C6)-haloalkyl, S(C1-C6)-haloalkyl, (C1-C6)-haloalkoxy, (C1-C6)-cyanoalkyl, (C3-C8)-cycloalkyl, NH2, NH(C1-C6)-alkyl, N((C1-C6)-alkyl)2, NH—CO—(C1-C6)-alkyl, NH—SO—(C1-C6)-alkyl, NH—S(O)2—(C1-C6)-alkyl, NH((C1-C6)-alkylen)-CO—(C1-C6)-alkyl, NH((C1-C6)-alkylen)-SO—(C1-C6)-alkyl, NH((C1-C6)-alkylen)-SO2—(C1-C6)-alkyl, NHCONH2, NH—CO—NH—(C1-C6)-alkyl, NH((C1-C6)-alkylen)-CO—N((C1-C6)-alkyl)2, CO2H, CO—O—(C1-C6)-alkyl, CONH2, CO—NH(C1-C6)alkyl and CO—N((C1-C6)-alkyl)2;
Y1 and Y2, at each occurrence are independently from one another selected from the group consisting of OH, ?O, CN, nitro, halogen, (C1-C6)-alkyl, (C1-C6)-hydroxyalkyl, (C1-C6)-alkoxy, S(C1-C6)-alkyl, S(O)—(C1-C6)-alkyl, S(O)2—(C1-C6)-alkyl, (C1-C6)-haloalkyl, S(C1-C6)-haloalkyl, (C1-C6)-haloalkoxy, (C1-C6)-cyanoalkyl, (C3-C8)-cycloalkyl, NH2, NH(C1-C6)-alkyl, N((C1-C6)-alkyl)2, NH—CO—(C1-C6)-alkyl, NH—SO—(C1-C6)-alkyl, NH—S(O)2—(C1-C6)-alkyl, NH((C1-C6)-alkylen)-CO—(C1-C6)-alkyl, NH((C1-C6)-alkylen)-SO—(C1-C6)-alkyl, NH((C1-C6)-alkylen)-SO2—(C1-C6)-alkyl, NHCONH2, NH—CO—NH—(C1-C6)-alkyl, NH((C1-C6)-alkylen)-CO—N((C1-C6)-alkyl)2, CO2H, CO—O—(C1-C6)-alkyl, CONH2, CO—NH(C1-C6)alkyl and CO—N((C1-C6)-alkyl)2;
Z at each occurrence is independently selected from the group consisting of halogen, OH, CN, SH, nitro, (C1-C6)-alkyl, (C2-C6)-alkenyl, (C2-C6)-alkinyl, (C1-C6)-hydroxyalkyl, (C1-C6)-cyanoalkyl, (C1-C6)-alkoxy, (C1-C6)-thioalkyl, (C1-C6)-haloalkyl, (C1-C6)-thiohaloalkyl, (C1-C6)-haloalkoxy, (C1-C6)-alkylen-S—(C1-C6)-alkyl, (C3-C8)-cycloalkyl, (C3-C6)-cycloalkyl-(C1-C3)-alkylenyl, (C3-C8)-heterocycloalkyl, NH2, NH(C1-C6)-alkyl, N((C1-C6)-alkyl)2, NH—CO—(C1-C6)-alkyl, NH—CO—O—(C1-C6)-alkyl, NH—C(O)NH2, NH—CO—NH—(C1-C6)-alkyl, NH—CO—N((C1-C6)-alkyl)2, NH((C1-C6)-alkylen)-CO—O—(C1-C6)-alkyl, NH((C1-C6)-alkylen)-CONH2, NH((C1-C6)-alkylen)-CO—NH—(C1-C6)-alkyl, NH((C1-C6)-alkylen)-CO—N((C1-C6)-alkyl)2, NH—S(O)2OH, NH—S(O)2(C1-C6)-alkyl, NH—S(O)2O(C1-C6)-alkyl, NH—S(O)2NH2, NH—S(O)2NH(C1-C6)-alkyl, NH—S(O)2N((C1-C6)-alkyl)2, NH((C1-C6)-alkylen)-S(O)2OH, NH((C1-C6)-alkylen)-S(O)2(C1-C6)-alkyl, NH((C1-C6)-alkylen)-S(O)2O(C1-C6)-alkyl, NH((C1-C6)-alkylen)-S(O)2NH2, NH((C1-C6)-alkylen)-S(O)2NH(C1-C6)-alkyl, CO2H, CO(C1-C6)-alkyl, CO—O(C1-C6)-alkyl, O—CO(C1-C6)-alkyl, O—CO—O(C1-C6)-alkyl, CONH2, CO—NH(C1-C6)-alkyl, CO—N((C1-C6)-alkyl)2, O—CO—NH(C1-C6)-alkyl, O—CO—N((C1-C6)-alkyl)2, O—S(O)2—(C1-C6)-alkyl, O—S(O)2OH, O—S(O)2—(C1-C6)-alkoxy, O—S(O)2NH2, O—S(O)2—NH(C1-C6)-alkyl, O—S(O)2—N((C1-C6)-alkyl)2, S(O)(C1-C6)-alkyl, S(O)2(C1-C6)-alkyl, S(O)2OH, S(O)2O(C1-C6)-alkyl, S(O)2NH2, S(O)2NH(C1-C6)-alkyl, and S(O)2N((C1-C6)-alkyl)2;
wherein the compound of formula (I) is in its presented form or its acid or base form, or in the form of a physiologically acceptable salt, or in its solvate form, or in the form of its racemates, its pure stereoisomers, enantiomers or diastereomers, or in the form of mixtures of stereoisomers, enantiomers or diastereomers, in any mixing ratio,
wherein the condition or disease is
psoriatic arthritis; or
psoriasis; or
chronic obstructive pulmonary disease (COPD).

US Pat. No. 10,189,850

CDK INHIBITORS

G1 Therapeutics, Inc., R...

1. A pharmaceutical composition comprising a pharmaceutically acceptable carrier and an effective amount of the compound of the structure:
wherein the pharmaceutical composition is in the form of a liquid dosage form.

US Pat. No. 10,189,844

PYRAZOLE DERIVATIVES AS PHOSPHOINOSITIDE 3-KINASES INHIBITORS

CHIESI FARMACEUTICI S.p.A...

1. A compound of formula (I):
wherein:
R1 and R4 and R5 may be the same or different and are each independently (C1-C6) alkyl, (C1-C6) haloalkyl, (C1-C6) hydroxyalkyl, (C1-C6) aminoalkyl, or aryl, each of which is optionally and independently substituted by one or more groups selected from the group consisting of halogen, —OH, —(CH2)pNR6R7, —CN, (C1-C6) alkyl, (C1-C6) haloalkyl, (C1-C6) hydroxyalkyl, (C2-C6) alkenyl, (C2-C6) alkynyl, and (C2-C6) hydroxyalkynyl;
R2 is H or (C1-C6) alkyl;
R3 is H;
Cy is a heteroaryl selected from the group consisting of I-1, I-2, and I-3 wherein I-1 is purinyl, I-2 is pyrazolo[3,4-d]pyrimidinyl, and I-3 is pyrimidinyl; each of which may be optionally and independently substituted by one or more groups selected from the group consisting of halogen, —OH, —(CH2)pNR6R7, —CN, —CH?NOH, —C(O)NR6R7, —C(O)OR6, (C1-C6) alkyl, (C1-C6) haloalkyl, (C1-C6) hydroxyalkyl, (C1-C6) alkanoyl, (C2-C6) alkenyl, (C2-C6) alkynyl, (C2-C6) hydroxyalkynyl, aryl, heteroaryl, and heterocycloalkyl, wherein said aryl, heteroaryl, and heterocycloalkyl may be optionally and independently substituted with one or more groups selected from the group consisting of —OH, halogen, —CN, —S(O)2NR6R7, —NR6S(O)2R7, —NR6R7, (C1-C6) alkyl, (C1-C6) haloalkyl, (C1-C6) hydroxyalkyl, and (C1-C6)alkoxy;
R6 and R7 may be the same or different and are each independently —H and (C1-C6) alkyl, (C1-C6) haloalkyl, (C1-C6) hydroxyalkyl, (C1-C6) aminoalkyl, (C1-C6) alkanoyl, or aryl (C1-C6) alkanoyl or, when R6 and R2 are both linked to a nitrogen atom, they may form, taken together with the nitrogen atom to which they are linked, a 4 to 6 membered heterocycle optionally containing one or more additional heteroatom or heteroatomic group selected from the group consisting of O, S, N, and NH; and
p is at each occurrence independently zero or an integer ranging from 1 to 3;
or a pharmaceutically acceptable salt thereof.

US Pat. No. 10,189,843

FUSED PYRAZOLE DERIVATIVE HAVING AUTOTAXIN INHIBITORY ACTIVITY

THE UNIVERSITY OF TOKYO, ...

1. A compound of formula (I) or a pharmaceutical acceptable salt thereof:
wherein
R1 is substituted or unsubstituted phenyl,
R2 is hydrogen,
R3 is hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted non-aromatic carbocyclyl, substituted or unsubstituted aromatic carbocyclyl, substituted or unsubstituted non-aromatic heterocyclyl, substituted or unsubstituted aromatic heterocyclyl, substituted or unsubstituted alkylcarbonyl, substituted or unsubstituted alkenylcarbonyl, substituted or unsubstituted alkynylcarbonyl, substituted or unsubstituted non-aromatic carbocyclylcarbonyl, substituted or unsubstituted aromatic carbocyclylcarbonyl, substituted or unsubstituted non-aromatic heterocyclyl carbonyl, substituted or unsubstituted aromatic heterocyclylcarbonyl, substituted or unsubstituted alkyloxycarbonyl, substituted or unsubstituted alkenyloxycarbonyl, substituted or unsubstituted alkynyloxycarbonyl, substituted or unsubstituted non-aromatic carbocyclyloxycarbonyl, substituted or unsubstituted aromatic carbocyclyloxycarbonyl, substituted or unsubstituted non-aromatic heterocyclyloxycarbonyl, substituted or unsubstituted aromatic heterocyclyloxycarbonyl, substituted or unsubstituted carbamoyl, substituted or unsubstituted sulfamoyl, substituted or unsubstituted alkyl sulfonyl, substituted or unsubstituted alkenylsulfonyl, substituted or unsubstituted alkynylsulfonyl, substituted or unsubstituted non-aromatic carbocyclylsulfonyl, substituted or unsubstituted aromatic carbocyclylsulfonyl, substituted or unsubstituted non-aromatic heterocyclylsulfonyl or substituted or unsubstituted aromatic heterocyclylsulfonyl,
R4a and R4b are each independently hydrogen, halogen, hydroxy, cyano, formyl, carboxy, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted non-aromatic carbocyclyl, substituted or unsubstituted aromatic carbocyclyl, substituted or unsubstituted non-aromatic heterocyclyl, substituted or unsubstituted aromatic heterocyclyl, substituted or unsubstituted amino, substituted or unsubstituted alkyloxy, substituted or unsubstituted alkenyloxy, substituted or unsubstituted alkynyloxy, substituted or unsubstituted non-aromatic carbocyclyloxy, substituted or unsubstituted aromatic carbocyclyloxy, substituted or unsubstituted non-aromatic heterocyclyloxy, substituted or unsubstituted aromatic heterocyclyloxy, substituted or unsubstituted alkylthio, substituted or unsubstituted alkenylthio, substituted or unsubstituted alkynylthio, substituted or unsubstituted non-aromatic carbocyclylthio, substituted or unsubstituted aromatic carbocyclylthio, substituted or unsubstituted non-aromatic heterocyclylthio, substituted or unsubstituted aromatic heterocyclylthio, substituted or unsubstituted alkyl carbonyl, substituted or unsubstituted alkenylcarbonyl, substituted or unsubstituted alkynylcarbonyl, substituted or unsubstituted non-aromatic carbocyclylcarbonyl, substituted or unsubstituted aromatic carbocyclylcarbonyl, substituted or unsubstituted non-aromatic heterocyclylcarbonyl, substituted or unsubstituted aromatic heterocyclylcarbonyl, substituted or unsubstituted alkyloxycarbonyl, substituted or unsubstituted alkenyloxycarbonyl, substituted or unsubstituted alkynyloxycarbonyl, substituted or unsubstituted non-aromatic carbocyclyloxycarbonyl, substituted or unsubstituted aromatic carbocyclyloxycarbonyl, substituted or unsubstituted non-aromatic heterocyclyloxycarbonyl, substituted or unsubstituted aromatic heterocyclyloxycarbonyl, substituted or unsubstituted carbamoyl, substituted or unsubstituted sulfamoyl, substituted or unsubstituted alkyl sulfinyl, substituted or unsubstituted alkenylsulfinyl, substituted or unsubstituted alkynylsulfinyl, substituted or unsubstituted non-aromatic carbocyclylsulfinyl, substituted or unsubstituted aromatic carbocyclylsulfinyl, substituted or unsubstituted non-aromatic heterocyclylsulfinyl, substituted or unsubstituted aromatic heterocyclylsulfinyl, substituted or unsubstituted alkyl sulfonyl, substituted or unsubstituted alkenyl sulfonyl, substituted or unsubstituted alkynylsulfonyl, substituted or unsubstituted aromatic carbocyclylsulfonyl, substituted or unsubstituted aromatic carbocyclylsulfonyl, substituted or unsubstituted non-aromatic heterocyclylsulfonyl or substituted or unsubstituted aromatic heterocyclylsulfonyl,
R5a is hydrogen, halogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted non-aromatic carbocyclyl, substituted or unsubstituted aromatic carbocyclyl, substituted or unsubstituted non-aromatic heterocyclyl, substituted or unsubstituted aromatic heterocyclyl, substituted or unsubstituted alkyloxy, substituted or unsubstituted alkenyloxy, substituted or unsubstituted alkynyloxy, substituted or unsubstituted non-aromatic carbocyclyloxy, substituted or unsubstituted aromatic carbocyclyloxy, substituted or unsubstituted non-aromatic heterocyclyloxy or substituted or unsubstituted aromatic heterocyclyloxy,
R5b is halogen, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted non-aromatic carbocyclyl, substituted or unsubstituted aromatic carbocyclyl, substituted or unsubstituted non-aromatic heterocyclyl, substituted or unsubstituted aromatic heterocyclyl, substituted or unsubstituted alkyloxy, substituted or unsubstituted alkenyloxy, substituted or unsubstituted alkynyloxy, substituted or unsubstituted non-aromatic carbocyclyloxy, substituted or unsubstituted aromatic carbocyclyloxy, substituted or unsubstituted non-aromatic heterocyclyloxy or substituted or unsubstituted aromatic heterocyclyloxy, or
R4b and R5a may be taken together to form a bond, R5b may be taken together with the substituent on R1 to form substituted or unsubstituted non-aromatic carbocycle or substituted or unsubstituted non-aromatic heterocycle, or R4b and R5b may be taken together to form substituted or unsubstituted non-aromatic carbocycle or substituted or unsubstituted non-aromatic heterocycle,
provided that
(i) a compound wherein R1 is substituted or unsubstituted phenyloxymethyl or substituted or unsubstituted pyridyloxymethyl, R2 is hydrogen, R5a is hydrogen or substituted or unsubstituted methyl, and R5b is substituted or unsubstituted methyl,
(ii) a compound wherein R3 is hydrogen or unsubstituted methyl, and either one of R5a and R5b or each of them are each independently unsubstituted methyloxy or unsubstituted ethyloxy, and
(iii) a compound represented as follows:

are excluded.

US Pat. No. 10,189,841

PURINONES AS UBIQUITIN-SPECIFIC PROTEASE 1 INHIBITORS

FORMA Therapeutics, Inc.,...

9. A pharmaceutical composition comprising, a compound of claim 1, and a pharmaceutically acceptable carrier.

US Pat. No. 10,189,840

SUBSTITUTED TRICYCLIC HETEROCYCLIC COMPOUNDS

Bristol-Myers Squibb Comp...

1. A compound of Formula (I)or a salt thereof, wherein:X is N;
W is:
(i) —(CR3R3)1-4—;
(ii) —(CR3R3)x—Y—(CR3R3)y—; or
(iii) —Y—(CR3R3)2—Y—;
each Y is independently O, NR4, or S(O)p;
x is zero, 1, 2, or 3;
y is zero, 1, 2, or 3, provided that (x+y) is zero, 1, 2, or 3;
R1 is H, R1a, C1-6 haloalkyl, C2-6 alkenyl substituted with zero to 6 R1a, C2-6 alkynyl substituted with zero to 4 R1a, —(CRgRg)r(3-14 membered carbocyclyl substituted with zero to 3 R1a), —(CRgRg)r(aryl substituted with zero to 3 R1a), —(CRgRg)r(5-7 membered heterocyclyl substituted with zero to 3 R1a), or —(CRgRg)r(mono- or bicyclic heteroaryl substituted with zero to 3 R1a);
R2 is H, halo, —CN, —CF3, —OCF3, —NO2, C1-6 alkyl substituted with zero to 6 R1a, —(CRgRg)rORe, —(CRgRg)rNRcRc, —(CRgRg)rS(O)pRb, —(CRgRg)r(3-14 membered carbocyclyl substituted with zero to 3 R1a), —(CRgRg)r(aryl substituted with zero to 3 R1a), —(CRgRg)r(5-7 membered heterocyclyl substituted with zero to 3 R1a), or —(CRgRg)r(monocyclic heteroaryl substituted with zero to 3 R1a);
each R3 is independently H, halo, —CN, —OH, —OCF3, C1-6 alkyl, C1-6 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, —(CRgRg)rC(O)Rb, —(CRgRg)rC(O)ORb, —(CRgRg)rC(O)NRcRc, —(CRgRg)rORe, —(CRgRg)rOC(O)Rb, —(CRgRg)rOC(O)NRcRc, —(CRgRg)rOC(O)ORd, —(CRgRg)rNRcRc, —(CRgRg)rNRbC(O)Rd, —(CRgRg)rNRbC(O)ORd, —(CRgRg)rNRbC(O)NRcRc, —(CRgRg)rNRbS(O)pRd, —(CRgRg)rS(O)pRb, —(CRgRg)rS(O)pNRcRc, —(CRgRg)r(3-14 membered carbocyclyl substituted with zero to 3 R1a), —(CRgRg)r(aryl substituted with zero to 3 R1a), —(CRgRg)r(5-7 membered heterocyclyl substituted with zero to 3 R1a), or —(CRgRg)r(mono- or bicyclic heteroaryl substituted with zero to 3 R1a);
each R4 is independently H, C1-6 alkyl substituted with zero to 6 R1a, C3-7 cycloalkyl substituted with zero to 6 R1a, —C(O)Rb, —C(O)NRcRc, —C(O)ORb, —S(O)2Rb, —S(O)2NRcRc, —S(O)2ORb, —(CRgRg)r(3-14 membered carbocyclyl substituted with zero to 3 R1a), —(CRgRg)r(aryl substituted with zero to 3 R1a), —(CRgRg)r(5-7 membered heterocyclyl substituted with zero to 3 R1a), or —(CRgRg)r(monocyclic heteroaryl substituted with zero to 3 R1a);
R5 is —(CRgRg)r(3-14 membered carbocyclyl substituted with zero to 3 R1a), —(CRgRg)r(aryl substituted with zero to 3 R1a), —(CRgRg)r(5-10 membered heterocyclyl substituted with zero to 3 R1a), or —(CRgRg)r(mono- or bicyclic heteroaryl substituted with zero to 3 R1a);
R6 is H, C1-6 alkyl, or C1-6 haloalkyl;
or R5 and R6 together with the carbon atom to which they are attached form a 5- to 6-membered spirocarbocyclyl ring or a spiroheterocyclyl ring, each substituted with zero to 6 R5a;
each R5a is independently selected from H, halo, —CN, —OH, C1-3 alkyl, C1-3 fluoroalkyl, or C1-3 alkoxy; or two R5a attached to neighboring carbon atoms of the spirocarbocyclic ring or the spiroheterocyclic ring, form a benzo ring along with the carbon atoms to which they are attached, said benzo substituted with zero to 4 Rf; or two R5a attached to the same carbon atom of the spirocarbocyclic ring or the spiroheterocyclic ring, form ?O;
R8 is H, halo, —CN, C1-6 haloalkyl, or C1-3 alkoxy;
each R1a is independently F, Cl, —CN, C1-6 alkyl substituted with zero to 6 Ra, C3-6 cycloalkyl substituted with zero to 6 Ra, C1-3 alkoxy substituted with zero to 6 Ra, C1-3 haloalkoxy, heterocycloalkyl substituted with zero to 6 Ra, aryl substituted with zero to 6 Ra, mono- or bicyclic heteroaryl substituted with zero to 6 Ra, —C(O)Rb, —C(O)ORb, —C(O)NRcRc, —OC(O)Rb, —OC(O)NRcRc, —OC(O)ORd, —NRcRc, —NRbC(O)Rd, —NRbC(O)ORd, —NRbS(O)pRd, —NRbC(O)NRcRc, —NRbS(O)pNRcRc, —S(O)pRb, —S(O)pNRcRc, or —C(O)NRb(CH2)1-3NRcRc;
each Ra is independently halo, —CN, —OH, —NO2, —NH2, C1-3 alkyl, C1-3 fluoroalkyl, C2-4 alkenyl, C2-4 alkynyl, C1-3 alkoxy, C1-3 fluoroalkoxy, —C(O)OH, —C(O)(C1-3 alkyl), —C(O)O(C1-4 alkyl), —OC(O)(C1-3 alkyl), —NH(C1-3 alkyl), —N(C1-3 alkyl)2, —C(O)NH(C1-3 alkyl), —OC(O)NH(C1-3 alkyl), —NHC(O)NH(C1-3 alkyl), —C(?NH)(NH2), C3-7 carbocyclyl, aryl, 5-7 membered heterocyclyl, mono- or bicyclic heteroaryl, —O(aryl), —O(benzyl), —O(heterocyclyl), —S(C1-3 alkyl), —S(aryl), —S(heterocyclyl), —S(O)(aryl), —S(O)(heterocyclyl), S(O)2(aryl), —S(O)2(heterocyclyl), —NHS(O)2(aryl), —NHS(O)2(heterocyclyl), —NHS(O)2NH(aryl), —NHS(O)2NH(heterocyclyl), —NH(aryl) —NH(heterocyclyl), —NHC(O)(aryl), —NHC(O)(C1-3 alkyl), —NHC(O)(heterocyclyl), —OC(O)(aryl), —OC(O)(heterocyclyl), —NHC(O)NH(aryl), —NHC(O)NH(heterocyclyl), —OC(O)O(C1-3 alkyl), —OC(O)O(aryl), —OC(O)O(heterocyclyl), —OC(O)NH(aryl), —OC(O)NH(heterocyclyl), —NHC(O)O(aryl), —NHC(O)O(heterocyclyl), —NHC(O)O(C1-3 alkyl), —C(O)NH(aryl), —C(O)NH(heterocyclyl), —C(O)O(aryl), —C(O)O(heterocyclyl), —N(C1-3 alkyl)S(O)2(aryl), —N(C1-3 alkyl)S(O)2(heterocyclyl), —N(C1-3 alkyl)S(O)2NH(aryl), —N(C1-3 alkyl)S(O)2NH(heterocyclyl), —N(C1-3 alkyl)(aryl), —N(C1-3 alkyl)(heterocyclyl), —N(C1-3 alkyl)C(O)(aryl), —N(C1-3 alkyl)C(O)(heterocyclyl), —N(C1-3 alkyl)C(O)NH(aryl), —(CH2)0-3C(O)NH(heterocyclyl), —OC(O)N(C1-3 alkyl)(aryl), —OC(O)N(C1-3 alkyl)(heterocyclyl), —N(C1-3 alkyl)C(O)O(aryl), —N(C1-3 alkyl)C(O)O(heterocyclyl), —C(O)N(C1-3 alkyl)(aryl), —C(O)N(C1-3 alkyl)(heterocyclyl), —NHS(O)2N(C1-3 alkyl)(aryl), —NHS(O)2N(C1-3 alkyl)(heterocyclyl), —NHP(O)2N(C1-3 alkyl)(aryl), —NHC(O)N(C1-3 alkyl)(aryl), —NHC(O)N(C1-3 alkyl)(heterocyclyl), —N(C1-3 alkyl)S(O)2N(C1-3 alkyl)(aryl), —N(C1-3 alkyl)S(O)2N(C1-3 alkyl)(heterocyclyl), —N(C1-3 alkyl)C(O)N(C1-3 alkyl)(aryl), —N(C1-3 alkyl)C(O)N(C1-3 alkyl)(heterocyclyl), or —Si(C1-3 alkyl)3;
each Rb is independently H, C1-6 alkyl substituted with zero to 6 Rf, C3-7 cycloalkyl substituted with zero to 6 Rf, heterocycloalkyl substituted with zero to 6 Rf, aryl substituted with zero to 3 Rf, or mono- or bicyclic heteroaryl substituted with zero to 3 Rf;
each Rc is independently H, C1-6 alkyl substituted with zero to 6 Rf, C3-7 cycloalkyl substituted with zero to 6 Rf, heterocycloalkyl substituted with zero to 6 Rf, aryl substituted with zero to 3 Rf, or mono- or bicyclic heteroaryl substituted with zero to 3 Rf; or when attached to the same nitrogen, two Rc along with the nitrogen atom to which they are attached form 4-8 membered heterocyclic ring optionally substituted with Rg;
each Rd is independently H, C1-6 alkyl substituted with zero to 6 Rf, C3-7 cycloalkyl substituted with zero to 6 Rf, heterocycloalkyl substituted with zero to 6 Rf, aryl substituted with zero to 3 Rf, or mono- or bicyclic heteroaryl substituted with zero to 3 Rf;
each Re is independently H, C1-6 alkyl substituted with zero to 6 Rf, C1-3 haloalkyl, C3-7 cycloalkyl substituted with zero to 6 Rf, heterocycloalkyl substituted with zero to 6 Rf, aryl substituted with zero to 3 Rf, or mono- or bicyclic heteroaryl substituted with zero to 3 Rf;
each Rf is independently H, halo, —OH, —CN, C1-6 alkyl substituted with zero to 6 Ra, C1-3 alkoxy, C3-7 cycloalkyl substituted with zero to 6 Ra, heterocycloalkyl substituted with zero to 6 Ra, aryl substituted with zero to 3 Ra, or mono- or bicyclic heteroaryl substituted with zero to 3 Ra;
each Rg is independently H, F, —OH, —CN, C1-3 alkyl, —CF3, or phenyl;
each p is independently zero, 1, or 2; and
each r is independently zero, 1, 2, 3, or 4.

US Pat. No. 10,189,834

IMIDAZO[4,5-C]QUINOLIN-2-ONE COMPOUNDS AND THEIR USE IN TREATING CANCER

AstraZeneca AB, Sodertal...

1. A compound of Formula (I):or a pharmaceutically acceptable salt thereof, where:Q is a cyclobutyl or cyclopentyl ring, each of which is optionally substituted by one hydroxy or methoxy group, or Q is an oxetanyl, tetrahydrofuranyl or oxanyl ring, each of which is optionally substituted by one methyl group;
R1 is methyl;
R2 is hydrogen or methyl; or R1and R2 together form an azetidinyl, pyrrolidinyl or piperidinyl ring;
R3 is hydrogen or fluoro;
R4 is hydrogen or methyl; and
R5 is hydrogen or fluoro.

US Pat. No. 10,189,829

INHIBITING AGENTS FOR BRUTON'S TYROSINE KINASE

BIOGEN MA INC., Cambridg...

1. A compound represented by the following formula:
or a pharmaceutically acceptable salt thereof.

US Pat. No. 10,189,828

1-METHYLPYRAZOLE-PIPERAZINE COMPOUNDS HAVING MULTIMODAL ACTIVITY AGAINST PAIN

LABORATORIOS DEL DR. ESTE...

1. A compound of formula (I):
wherein
n is 1, 2, 3, 4, 5 or 6;
Y—W is CRY—N;
X is a bond or —CR6R6—;
R1 is substituted or unsubstituted cycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heterocyclyl;
R2 is substituted or unsubstituted C1-6 alkyl, substituted or unsubstituted C2-6 alkenyl, substituted or unsubstituted C2-6 alkynyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heterocyclyl;
R3 is hydrogen, substituted or unsubstituted C1-6 alkyl, substituted or unsubstituted C2-6 alkenyl, substituted or unsubstituted C2-6 alkynyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted alkylcycloalkyl, substituted or unsubstituted alkylaryl, or substituted or unsubstituted alkylheterocyclyl;
R4, R4? , R4? and R4?? are independently selected from hydrogen or unsubstituted C1-6 alkyl, unsubstituted C2-6 alkenyl, and unsubstituted C2-6 alkynyl;
R5 and R5? are independently selected from hydrogen or unsubstituted C1-6 alkyl, unsubstituted C2-6 alkenyl, and unsubstituted C2-6 alkynyl;
R6 is selected from hydrogen, halogen, —OR7, substituted or unsubstituted C1-6 alkyl, substituted or unsubstituted C2-6 alkenyl, substituted or unsubstituted C2-6 alkynyl, —C(O)OR7, —C(O)NR7R7?, —NR7C(O)R7?, and —NR7R7??—;
R6? is selected from hydrogen, substituted or unsubstituted C1-6 alkyl, substituted or unsubstituted C2-6 alkenyl, and substituted or unsubstituted C2-6 alkynyl;
wherein R7 and R7? are independently selected from hydrogen, unsubstituted C1-6 alkyl, unsubstituted C2-6 alkenyl, unsubstituted C2-6 alkynyl , and unsubstituted acetyl;
and R7?? is selected from hydrogen, unsubstituted C1-6 alkyl, unsubstituted C2-6 alkenyl, unsubstituted C2-6 alkynyl and -Boc;
Ry is selected from hydrogen, substituted or unsubstituted C1-6 alkyl, substituted or unsubstituted C2-6 alkenyl, and substituted or unsubstituted C2-6 alkynyl;
optionally as a stereoisomer, a racemate or a mixture of at least two of stereoisomers, in any mixing ratio, or a corresponding salt thereof.

US Pat. No. 10,189,825

HETEROARYL COMPOUNDS AND METHODS OF USE THEREOF

SUNOVION PHARMACEUTICALS ...

1. A compound of formula (I):
or a pharmaceutically acceptable salt thereof, wherein
X is selected from S and O;
one of R1a and R1b is

wherein
R5 is selected from hydrogen, alkyl, and C3-20 cycloalkyl;
R6 is selected from hydrogen, cyano, amino, alkylamino, alkyl, alkoxyl, alkenyl, alkynyl, C3-20 cycloalkyl, C3-20 cycloalkyl-C1-20 alkyl, C6-20 aryl, C6-20 aryl-C1-20 alkyl, C3-20 heterocyclyl with 1-2 heteroatoms selected from O, N, S, and combinations thereof, and C5-20 heteroaryl with 1-2 heteroatoms selected from O, N, S, and combinations thereof,
R7, and R8 are each independently selected from hydrogen, halo, cyano, amino, alkylamino, alkyl, alkoxyl, alkenyl, alkynyl, C3-20 cycloalkyl, C3-20 cycloalkyl-C1-20 alkyl, C6-20 aryl, C6-20 aryl-C1-20 alkyl, C3-20 heterocyclyl with 1-2 heteroatoms selected from O, N, S, and combinations thereof, and C5-20 heteroaryl with 1-2 heteroatoms selected from O, N, S, and combinations thereof;
and the other of R1a and R1b is selected from hydrogen, halo, cyano, alkyl, alkoxyl, alkenyl, alkynyl, C3-20 cycloalkyl, C3-20 cycloalkyl-C1-20 alkyl, C6-20 aryl, C6-20 aryl-C1-20 alkyl, C3-20 heterocyclyl with 1-2 heteroatoms selected from O, N, S, and combinations thereof, and C5-20 heteroaryl with 1-2 heteroatoms selected from O, N, S, and combinations thereof; and
R2 and R3 and the atoms to which they are attached form a benzene ring,
wherein each amino, alkylamino, alkyl, alkoxyl, alkenyl, alkynyl, C3-20 cycloalkyl, C3-20 cycloalkyl-C1-20 alkyl, C6-20 aryl, benzene ring, C6-20 aryl-C1-20 alkyl, C3-20 heterocyclyl, and C5-20 heteroaryl thereof is optionally substituted.

US Pat. No. 10,189,816

SUBSTITUTED PYRIDINES AS INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION

ViiV HEALTHCARE UK (NO. 5...

2. A compound of claim 1, wherein the compound is:or a pharmaceutically acceptable salt thereof.

US Pat. No. 10,189,815

2-(3-PYRIDINYL)-1H-BENZIMIDAZOLE DERIVATIVE COMPOUND AND MEDICINE CONTAINING SAME

NIHON MEDI-PHYSICS CO., L...

1. A compound represented by the following general formula (1) or a salt thereof:
wherein R1 represents a hydrogen atom or CO2Ra, R2 represents a hydrogen atom, a halogen atom or CO2Ra, R3 represents a hydrogen atom or a hydroxyalkyl group containing 1 to 10 carbon atoms, R4 represents a hydrogen atom, a hydroxy group or an alkoxy group containing 1 to 10 carbon atoms, R5 represents a linear alkyl group containing 1 to 5 carbon atoms in which a hydrogen atom is optionally replaced by a halogen atom, a cyclic alkyl group containing 3 to 5 carbon atoms in which a hydrogen atom is optionally replaced by a halogen atom, a hydroxyalkyl group containing 1 to 5 carbon atoms, or an o-, p- or m-halobenzyl group, A represents CH or a nitrogen atom, X1 and X3 each independently represent a hydrogen atom or a halogen atom, X2 represents a hydrogen atom, a halogen atom or a nitrile group, provided that at least one of X1, X2 and X3 represents a halogen atom, and each Ra independently represents an alkyl group containing 1 to 10 carbon atoms.

US Pat. No. 10,189,814

ARYLMETHOXY ISOINDOLINE DERIVATIVES AND COMPOSITIONS COMPRISING AND METHODS OF USING THE SAME

Celgene Corporation, Sum...

1. A method for treating or managing a disease or disorder for therapeutic benefit comprising administering to a patient a therapeutically effective amount of a compound of formula (IV):
or a pharmaceutically acceptable salt, solvate or stereoisomer thereof, wherein:
X is NR11 or NR12 when only one of R11 and R12 is attached to X, or X is CR11R12 when both R11 and R12 are attached to X;
Y is CH2 or C?O;
R11 and R12 are each independently hydrogen, —(C1-C6)alkyl, —(C1-C6)alkyl-(C3-C6)cycloalkyl, —(C1-C6)alkoxy, —(C6-C10)aryl, —CO(C1-C6)alkyl, —CO(C3-C6)cycloalkyl, —CO(C6-C10)aryl, —COO(C1-C6)alkyl, halogen, hydroxyl, oxo, 3 to 10 membered heterocycle, 6 to 10 membered heteroaryl, —NHCO(C1-C6)alkyl, —(CH2)n-phenyl, —SO2(C1-C6)alkyl, —SO2(C3-C6)cycloalkyl, —SO2(C6-C10)aryl or —NR14R15, wherein the alkyl, aryl or heteroaryl portion of each of the groups may be optionally substituted with one or more halogen, hydroxyl or —(C1-C6)alkoxy;
R13 is hydrogen or —(C1-C6)alkyl;
R14 and R15 are each independently hydrogen or —(C1-C6)alkyl; and
n is 0, 1, 2 or 3; and
wherein the disease or disorder is cancer, a disorder associated with angiogenesis, pain, macular degeneration, a skin disease, a parasitic disease, CNS injury, atherosclerosis, dysfunctional sleep, an infectious disease, or hemoglobinopathy.

US Pat. No. 10,189,813

FORMYLATED N-HETEROCYCLIC DERIVATIVES AS FGFR4 INHIBITORS

NOVARTIS AG, Basel (CH)

1. A compound of formula (I) in free form or in pharmaceutically acceptable salt form
wherein
X is N or CH;
A is C(O) and B is NR5 or
A and B together form part of a 5- or 6-membered aromatic ring wherein A is C and B is C or N;
R1 is selected from hydrogen, hydroxyC1-C3alkyl, haloC1-C3alkyl, CO2H, CH2NR2R3, a 5-membered aromatic heterocyclic ring comprising at least one heteroatom selected from N, O or S, which ring is optionally substituted once or more than once with C1-C3alkyl;
R2 is C1-C3alkyl and R3 is C(O)C1-C3alkyl
or
R2 and R3 together with the N to which they are attached form a saturated 5- or 6-membered ring optionally comprising one additional heteroatom selected from N, O or S, which ring is optionally substituted once or more than once with R4;
R4 is for each occurrence independently selected from C1-C3alkyl, C1-C3alkoxy or two R4 attached at the same carbon atom form an oxo group;
R5 is selected from hydrogen, C1-C3alkyl, C1-C3alkoxyC1-C3alkyl, (CH2)0-1—R6;
R6 is a 4-, 5-, or 6-membered saturated heterocyclic ring comprising at least one heteroatom selected from N, O, or S;
R7 is selected from cyano, haloC1-C3alkyl;
R8 is selected from hydrogen, NR9R10, C1-C6alkoxy;
R9 is hydrogen;
R10 is selected from C1-C6alkyl, hydroxyC1-C6alkyl, C1-C4alkoxyC1-C6alkyl.

US Pat. No. 10,189,799

PROCESS FOR PREPARING SUBSTITUTED PHENYLISOXAZOLINE DERIVATIVES

BAYER CROPSCIENCE AKTIENG...

1. Process for preparing one or more phenylisoxazoline derivatives of formula (I)
wherein
R1 is methyl, bromomethyl or chloromethyl;
R2 is halogen, C1-C4-alkyl, C1-C4-alkoxy, C1-C4-haloalkyl and
R3 is C1-C4-alkylsulphonyloxy, C1-C4-haloalkylsulphonyloxy,
wherein, in (i), a chloroxime of formula (II)

wherein R4 is C1-C12-alkyl,
is reacted with a styrene of formula (III)

wherein R2 and R3 are as defined above,
in the presence of an inorganic base in an organic aprotic solvent to give the corresponding phenylisoxazoline of formula (IV)

wherein R2, R3 and R4 are as defined above,
and the latter then reacts, in (ii), with an organometallic reagent and an organic base in an organic aprotic solvent to give the ketone of formula (Ia)

wherein R2 and R3 are as defined above,
and then, in (iii), in the presence of a halogenating agent in a solvent, the haloketone of formula (Ib) is formed

wherein R2 and R3 are as defined above and
X is chlorine or bromine.

US Pat. No. 10,189,796

[4-(1,3,3-TRIMETHYL-2-OXO-3,4-DIHYDRO-1H-QUINOXALIN-7-YL)PHENOXY]ETHYLOXY COMPOUND OR SALT THEREOF

SANTEN PHARMACEUTICAL CO....

1. A compound of general formula (1):
wherein R1 represents a hydrogen atom, a lower alkyl group which may have a substituent(s), a carboxyl group, an ester of a carboxyl group, an amide of a carboxyl group or a cyano group; and
R2 represents a hydrogen atom, a lower alkylcarbonyl group which may have a substituent(s), a lower cycloalkylcarbonyl group which may have a substituent(s), an arylcarbonyl group which may have a substituent(s), a heterocyclic carbonyl group which may have a substituent(s), an ester of a carboxyl group, an amide of a carboxyl group, a phosphate group or an ester of a phosphate group,
or a salt thereof.

US Pat. No. 10,189,794

HETEROARYL COMPOUNDS AND USES THEREOF

Celgene CAR LLC, Pembrok...

1. A method for inhibiting activity of FGFR4, or a mutant thereof, in a patient or biological sample, comprising the step of administering to said patient or biological sample a compound of formula I:
or a pharmaceutically acceptable salt thereof, wherein:
X1 is —NR4, N, —CR4R4?, or —CR4;
X2 is —NR5, N, —CR5R5?, or —CR5;
X3 is N or CR6
X4 is N or CR7;
X5 is N, C, or CH; wherein at least one of X1, X2, X3, X4, or X5 is N;
G is H, O, OR, or N(R)(R);
Ring A is an optionally substituted group selected from a 3-8 membered saturated or partially unsaturated carbocyclic ring, a 5-6 membered monocyclic heteroaryl ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur, a 4-7 membered saturated or partially unsaturated heterocyclic ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur, or a 7-10 membered bicyclic saturated, partially unsaturated or aryl ring;
each R is independently hydrogen or an optionally substituted group selected from C1-6 aliphatic, phenyl, a 3-8 membered saturated or partially unsaturated carbocyclic ring, a 4-7 membered heterocyclic ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur, or a 5-6 membered monocyclic heteroaryl ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur; or
two R groups on the same nitrogen are taken together with the nitrogen atom to which they are attached to form a 4-7 membered heterocyclic ring having 0-2 additional heteroatoms independently selected from nitrogen, oxygen, or sulfur, or a 4-7 membered heteroaryl ring having 0-4 additional heteroatoms independently selected from nitrogen, oxygen, or sulfur;
R1 is a warhead group -L-Y; wherein R1 is attached to an atom adjacent to the atom where T is attached, wherein:
orL is a bivalent C2-8 straight or branched, hydrocarbon chain wherein L has at least one double bond and one or two methylene units of L are optionally and independently replaced by —NRC(O)—, —C(O)NR—, —N(R)SO2—, —SO2N(R)—, —S—, —S(O)—, —SO2—, —OC(O)—, —C(O)O—, cyclopropylene, —O—, —N(R)—, or —C(O)—; or
L is a bivalent C2-8 straight or branched, hydrocarbon chain wherein L has at least one alkylidenyl double bond and at least one methylene unit of L is replaced by —C(O)—, —NRC(O)—, —C(O)NR—, —N(R)SO2—, —SO2N(R)—, —S—, —S(O)—, —SO2—, —OC(O)—, or —C(O)O—, and one additional methylene unit of L is optionally replaced by cyclopropylene, —O—, —N(R)—, or —C(O)—; or
L is a bivalent C2-8 straight or branched, hydrocarbon chain wherein one methylene unit of L is replaced by cyclopropylene and one additional methylene unit of L is replaced by —NRC(O)—, —C(O)NR—, —N(R)SO2—, —SO2N(R)—, —S—, —S(O)—, —SO2—, —OC(O)—, or —C(O)O—; or
L is a bivalent C2-8 straight or branched, hydrocarbon chain wherein L has at least one triple bond and one or two methylene units of L are optionally and independently replaced by —NRC(O)—, —C(O)NR—, —N(R)SO2—, —SO2N(R)—, —S—, —S(O)—, —SO2—, —OC(O)—, or —C(O)O—; and
the Y group of R1 is hydrogen, C1-6 aliphatic optionally substituted with oxo, halogen, NO2, or CN, or a 3-10 membered monocyclic or bicyclic, saturated, partially unsaturated, or aryl ring having 0-3 heteroatoms independently selected from nitrogen, oxygen, or sulfur, and wherein said ring is substituted with 1-4 Re groups; or
L is a covalent bond, —CH2—, —NH—, —C(O)—, —CH2NH—, —NHCH2—, —NHC(O)—, —NHC(O)CH2OC(O)—, —CH2NHC(O)—, —NHSO2—, —NHSO2CH2—, or —SO2NH—, and the Y group of R1 is selected from:
(i) C1-6 alkyl substituted with oxo, halogen, NO2, or CN; or
(ii) C2-6 alkenyl substituted with oxo, halogen, NO2, or CN; or
(iii) C2-6 alkynyl optionally substituted with oxo, halogen, NO2, or CN; or
(iv) a saturated 3-4 membered heterocyclic ring having 1 heteroatom selected from oxygen or nitrogen wherein said ring is substituted with 1-2 Re groups; or
(v) a saturated 5-6 membered heterocyclic ring having 1-2 heteroatom selected from oxygen or nitrogen wherein said ring is substituted with 1-4 Re groups; or
(vi)

 or
(vii) a saturated 3-6 membered carbocyclic ring, wherein said ring is substituted with 1-4 Re groups; or
(viii) a partially unsaturated 3-6 membered monocyclic ring having 0-3 heteroatoms independently selected from nitrogen, oxygen, or sulfur, wherein said ring is substituted with 1-4 Re groups; or
(ix) a partially unsaturated 3-6 membered carbocyclic ring, wherein said ring is substituted with 1-4 Re groups; or
(x)

 or
(xi) a partially unsaturated 4-6 membered heterocyclic ring having 1-2 heteroatoms independently selected from nitrogen, oxygen, or sulfur, wherein said ring is substituted with 1-4 Re groups; or
(xii)

 or
(xiii) a 6-membered aromatic ring having 0-2 nitrogens wherein said ring is substituted with 1-4 Re groups; or
(xiv)

 or
(xv) a 5-membered heteroaryl ring having 1-3 heteroatoms independently selected from nitrogen, oxygen, or sulfur, wherein said ring is substituted with 1-3 Re groups; or
(xvi)

 or
(xvii) an 8-10 membered bicyclic, saturated 3-4 membered heterocyclic, or aryl ring having 0-3 heteroatoms independently selected from nitrogen, oxygen, or sulfur, wherein said ring is substituted with 1-4 Re groups; or
L is a covalent bond, —C(O)—, —N(R)C(O)—, or a bivalent C1-8 saturated or unsaturated, straight or branched, hydrocarbon chain; and the Y group of R1 is selected from:
(i) C1-6 alkyl substituted with oxo, halogen, NO2, or CN; or
(ii) C2-6 alkenyl optionally substituted with oxo, halogen, NO2, or CN; or
(iii) C2-6 alkynyl optionally substituted with oxo, halogen, NO2, or CN; or
(iv) a saturated 3-4 membered heterocyclic ring having 1 heteroatom selected from oxygen or nitrogen wherein said ring is substituted with 1-2 Re groups; or
(v) a saturated 5-6 membered heterocyclic ring having 1-2 heteroatom selected from oxygen or nitrogen wherein said ring is substituted with 1-4 Re groups; or
(vi)

 or
(vii) a saturated 3-6 membered carbocyclic ring, wherein said ring is substituted with 1-4 Re groups; or
(viii) a partially unsaturated 3-6 membered monocyclic ring having 0-3 heteroatoms independently selected from nitrogen, oxygen, or sulfur, wherein said ring is substituted with 1-4 Re groups; or
(ix) a partially unsaturated 3-6 membered carbocyclic ring, wherein said ring is substituted with 1-4 Re groups; or
(x)

 or
(xi) a partially unsaturated 4-6 membered heterocyclic ring having 1-2 heteroatoms independently selected from nitrogen, oxygen, or sulfur, wherein said ring is substituted with 1-4 Re groups; or
(xii)

 or
(xiii) a 6-membered aromatic ring having 0-2 nitrogens wherein said ring is substituted with 1-4 Re groups; or
(xiv)

 or
(xv) a 5-membered heteroaryl ring having 1-3 heteroatoms independently selected from nitrogen, oxygen, or sulfur, wherein said ring is substituted with 1-3 Re groups; or
(xvi)

 or
(xvii) an 8-10 membered bicyclic, saturated, partially unsaturated, or aryl ring having 0-3 heteroatoms independently selected from nitrogen, oxygen, or sulfur, wherein said ring is substituted with 1-4 Re groups;
each Re is independently selected from -Q-Z, oxo, NO2, halogen, CN, C1-6 aliphatic optionally substituted with oxo, halogen, NO2, or CN, or a suitable leaving group selected from alkoxy, sulphonyloxy, optionally substituted alkylsulphonyloxy, optionally substituted alkenylsulfonyloxy, optionally substituted arylsulfonyloxy, acyl, or diazonium, wherein:
Q is a bivalent C1-6 saturated or unsaturated, straight or branched, hydrocarbon chain, wherein one or two methylene units of Q are optionally and independently replaced by —N(R)—, —S—, —O—, —C(O)—, —OC(O)—, —C(O)O—, —SO—, —SO2—, —N(R)C(O)—, —C(O)N(R)—, —N(R)SO2—, or —SO2N(R)—; and
each Z is independently hydrogen or C1-6 aliphatic substituted with oxo, halogen, NO2, or CN;
each R2 is independently —R, halogen, -haloalkyl, —OR, —SR, —CN, —NO2, —SO2R, —SOR, —C(O)R, —CO2R, —C(O)N(R)2, —NRC(O)R, —NRC(O)N(R)2, —NRSO2R, or —N(R)2;
R3 is hydrogen, C2-6 alkenyl, —W-Cy, or C1-6 alkyl, wherein the C1-6 alkyl is optionally substituted with 1-3 groups independently selected from halogen, —CN, oxo, —OR?, or —C(O)O(C1-6 alkyl);
W is absent or is a bivalent C1-3 alkylene chain optionally substituted with one or more R? and
wherein one methylene unit of W is optionally replaced with —O—, —S—, or —NR?—;
each R? is independently hydrogen or C1-6 alkyl;
each R? is independently halogen or C1-6 alkyl, wherein the C1-6 alkyl is optionally substituted with 1-3 groups independently selected from halogen, —CN, oxo, or —OR?;
Cy is phenyl, C3-7 cycloalkyl, or a 3-7 membered monocyclic or 5-10 membered bicyclic saturated, partially unsaturated, or heteroaryl ring having 1-3 heteroatoms independently selected from nitrogen, oxygen, or sulfur, wherein Cy is optionally substituted with 1-3 Rx;
each Rx is independently H, —CN, oxo, —NH2, C1-6 alkyl, halogen, —OR?, —N(R?)2, —NHC(O)(C1-6 alkyl), —C(O)N(R?)2, —C(O)O(C1-6 alkyl), —NHSO2(C1-6 alkyl), or —SO2N(R?)2;
or R3 is absent if not allowed by valence;
each of R4 and R4? is independently hydrogen or an optionally substituted group selected from C1-6 aliphatic, phenyl, a 3-8 membered saturated or partially unsaturated carbocyclic ring which is optionally bridged, a 4-7 membered heterocyclic ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur, a 5-6 membered monocyclic heteroaryl ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur, or a 7-10 membered bicyclic saturated, partially unsaturated or aryl ring, which is optionally bridged;
each of R5 and R5? is independently —R, halogen, —OR, —SR, —CN, —NO2, —SO2R, —SOR, —C(O)R, —CO2R, —C(O)N(R)2, —NRC(O)R, —NRC(O)N(R)2, —NRSO2R, or —N(R)2;
Y is O or NRa?;
Ra is hydrogen or an optionally substituted C1-6 aliphatic group;
T is a covalent bond or a bivalent straight or branched, saturated or unsaturated C1-6 hydrocarbon chain wherein one or more methylene units are optionally replaced by —O—, —S—, —N(R)—, —C(O)—, —OC(O)—, —C(O)O—, —C(O)N(R)—, —N(R)C(O)—, —N(R)C(O)N(R)—, —S(O)—, —SO2—, —SO2N(R)—, —N(R)SO2—, or —N(R)SO2N(R)—;
q is 0-6; and
each of R6 and R7 is independently —R, halogen, —OR, —SR, —CN, —NO2, —SO2R, —SOR, —C(O)R, —CO2R, —C(O)N(R)2, —NRC(O)R, —NRC(O)N(R)2, —NRSO2R, or —N(R)2.

US Pat. No. 10,189,789

PROCESS FOR THE PREPARATION OF ANDROGEN RECEPTOR ANTAGONISTS AND INTERMEDIATES THEREOF

Orion Corporation, Espoo...

1. A method for preparing 2-chloro-4-(1H-pyrazol-3-yl)benzonitrile of formula (V)comprising the steps ofa) reacting 1-(tetrahydro-2H-pyran-2-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole of formula (I)
with 4-bromo-2-chlorobenzonitrile of formula (II)at an elevated temperature in the presence of Pd(OAc)2, triphenylphosphine and a base in an acetonitrile-water solvent to form 2-chloro-4-(1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazol-5-yl)benzonitrile of formula (III)
b) treating the compound of formula (III) with a catalytic amount of HCl in a methanol solvent;
c) adding a base to neutralize the mixture; and
d) isolating the compound of formula (V).

US Pat. No. 10,189,788

SUBSTITUTED N,2-DIARYLQUINOLINE-4-CARBOXAMIDES AND THE USE THEREOF AS ANTI-INFLAMMATORY AGENTS

BAYER PHARMA AKTIENGESELL...

1. A compound of the formula (I)
in which
RA is hydrogen, halogen, pentafluorosulfanyl, cyano, nitro, (C1-C4)-alkyl, hydroxyl, (C1-C4)-alkoxy, amino or a group of the formula —NH—C(?O)—R6, —NH—C(?O)—NH—R6 or —S(?O)n—R7, where (C1-C4)-alkyl and (C1-C4)-alkoxy may be up to trisubstituted by fluorine,
and in which
R6 is hydrogen or (C1-C4)-alkoxy which may be up to trisubstituted by fluorine,
R7 is (C1-C4)-alkyl which may be substituted by hydroxyl, methoxy or ethoxy or up to trisubstituted by fluorine,
and
n is the number 0, 1 or 2,
D is C-RD or N,
E is C-RE or N,
G is C-RG or N,
where not more than two of the ring members D, E and G at the same time are N,
and in which
RD and RE are each independently hydrogen, fluorine, chlorine, methyl, trifluoromethyl, methoxy or trifluoromethoxy,
and
RG is hydrogen, fluorine, chlorine, bromine, methyl or trifluoromethyl,
Z is OH or a group of the formula —NH—R8, —NH—SO2—R9 or —NH—SO2—NR10AR10B, in which
R8 is hydrogen or (C1-C4)-alkoxy which may be up to trisubstituted by fluorine,
R9 is (C1-C4)-alkoxy which may be up to trisubstituted by fluorine, or phenyl,
and
R10A and R10B are each independently hydrogen or (C1-C4)-alkyl which may be up to trisubstituted by fluorine,
R1 is halogen, trifluoromethoxy, (trifluoromethyl)sulfanyl, pentafluorosulfanyl, (C1-C4)-alkyl, trimethylsilyl, cyclopropyl or cyclobutyl,
where (C1-C4)-alkyl may be up to trisubstituted by fluorine
and
cyclopropyl and cyclobutyl may be up to disubstituted by fluorine,
R2, R3 and R4 are each independently hydrogen, fluorine, chlorine, methyl or trifluoromethyl,
R5 is (C1-C4)-alkyl which may be up to trisubstituted by fluorine, or is fluorine, chlorine, methoxy or cyclopropyl,
and
Ar is phenyl which may be mono- or disubstituted identically or differently by fluorine and chlorine, or is pyridyl or thienyl,
and the N-oxides, salts, solvates, salts of the N-oxides and solvates of the N-oxides and salts thereof.

US Pat. No. 10,189,787

INHIBITORS OF HISTONE DEMETHYLASES

Gilead Sciences, Inc., F...

1. A compound of Formula (I)whereinA is —CH2C(O)—;
Y is —NR6R7; p1 R1 is —H;
Z is selected from a single bond, C1-4 alkylene, heterocyclylene and C3-6 cycloalkylene;
each R4 is independently selected from C1-6 alkyl, C1-4 fluoroalkyl, C1-4 hydroxyalkyl, C1-4 alkoxy, C3-10 cycloalkyl, —N(R10)2, carbamoyl, and —OH;
each R5 is independently selected from C1-6 alkyl, C1-4 fluoroalkyl, C1-4 hydroxyalkyl, C1-4 alkoxy, C3-6 cycloalkyl, —CN, —F, —Cl, —Br, carbamoyl and —OH;
each of R6 and R7 is independently selected from —H, C1-8 alkyl, C1-4 fluoroalkyl, C1-4 hydroxyalkyl, C2-8 alkenyl, C2-8 alkynyl, C3-10 cycloalkyl, —Z-heterocyclyl, —Z-heteroaryl and —Z-aryl, wherein alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, heteroaryl and aryl may optionally be substituted with one or more independently selected R8;
each R8 is independently selected from C1-6 alkyl, C1-4 fluoroalkyl, C1-4 hydroxyalkyl, C2-6 alkenyl, C2-6 alkynyl, C3-10 cycloalkyl, —Z-heterocyclyl, —Z-heteroaryl, —Z-aryl, —Z—NR10R11, —Z—C(?O)—NR10R11, —Z—OR9, halogen, —CN, —Z—SR9, —Z—SOR9, —Z—SO2R9 and —Z—COOR9, wherein alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, heteroaryl and aryl may optionally be substituted with one or more selected from C1-4 alkyl, C1-4 fluoroalkyl, C1-4 hydroxyalkyl, C3-6 cycloalkyl, —Z-heterocyclyl, —Z-heteroaryl, —Z-aryl, —Z—NR10R11,—Z—C(?O)—NR10R11,—Z—OR9, halogen, —CN, —Z—SR9, —Z—SOR9, —Z—SO2R9 and —Z—COOR9; wherein any heterocyclyl may be further substituted with one or more R4 as defined above, and wherein any heteroaryl and any aryl may be further substituted with one or more R5 as defined above;
each R9 is independently selected from —H, C1-8 alkyl, C1-4 fluoroalkyl, C1-4 hydroxyalkyl, C2-8 alkenyl, C2-8 alkynyl, C3-10 cycloalkyl, —Z-heterocyclyl, —Z-aryl, and —Z— heteroaryl, wherein any heterocyclyl may be substituted with one or more R4 as defined above, and wherein any heteroaryl and any aryl may be substituted with one or more R5 as defined above; and
each of R10 and R11 is independently selected from —H, C1-6 alkyl, C1-4 fluoroalkyl, C1-4 hydroxyalkyl, C2-8 alkenyl, C2-8 alkynyl, C3-10 cycloalkyl, heterocyclyl, heteroaryl, and aryl, wherein any heterocyclyl may be substituted with one or more R4 as defined above, and wherein any heteroaryl and any aryl may be substituted with one or more R5 as defined above;
or a pharmaceutically acceptable salt thereof.

US Pat. No. 10,189,786

ANTIBACTERIAL COMPOUNDS

DUKE UNIVERSITY, Durham,...

1. A compound of the formula:
or a pharmaceutically acceptable salt thereof, wherein
X1 represents —CH2—, —(CH2)2—, —(CH2)3—, —CH?CH—, —CH?CHCH2—, —CH2CH?CH—, —C(O)NH—, or —C(O)NH—CH2—;
X2 represents CH2 or NR13;
Y1 represents phenyl optionally substituted with R14, or thiophenyl optionally substituted with R14;
Z1 represents phenyl optionally substituted with R15, or thiophenyl optionally substituted with R15;
R12 is hydrogen, C1-C6 alkyl optionally substituted with R16, or thiophenyl optionally substituted with R16;
and

 moiety is of formula:

wherein
R13 is hydrogen or C1-C6 alkyl;
each R14 is independently selected from the group consisting of halogen, —NO2, —CN, C1-C6 alkyl, C1-C6 haloalkyl, —NH2, —NH(C1-C6 alkyl), —N(C1-C6 alkyl)2, —OH, C1-C6 alkoxy, and C1-C6 haloalkoxy;
each R15 is independently selected from the group consisting of halogen, —NO2, —CN, C1-C6 alkyl, C1-C6 haloalkyl, —NH2, —NH(C1-C6 alkyl), —N(C1-C6 alkyl)2, —OH, C1-C6 alkoxy, and C1-C6 haloalkoxy;
each R16 is independently selected from the group consisting of halogen, —NO2, —CN, C1-C6 alkyl, C1-C6 haloalkyl, —NH2, —NH(C1-C6 alkyl), —N(C1-C6 alkyl)2, —OH, C1-C6 alkoxy, C1-C6 haloalkoxy, aryl, aryl(C1-C6 alkyl), heteroaryl, heteroaryl(C1-C6 alkyl), heterocyclyl, and heterocyclyl(C1-C6 alkyl), wherein each alkyl, aryl, heteroaryl, or heterocyclyl moiety is optionally substituted with one or more R11;
R18 is independently selected from the group consisting of —CONH2, —CON(C1-C6 alkyl), —CON(C1-C6 alkyl)2, —CONH—OH, —CONH—NH2, —CO2H, and —CO2(C1-C6 alkyl);
R19 is hydrogen or C1-C6 alkyl;
R27 is selected from the group consisting of hydrogen, halogen, C1-C6 alkyl, C1-C6 haloalkyl, —NH2, —NH(C1-C6 alkyl), —N(C1-C6 alkyl)2, —OH, C1-C6 alkoxy, C1-C6 haloalkoxy, —SH, —S(C1-C6 alkyl), hydroxy(C1-C6 alkyl), alkoxy(C1-C6 alkyl), amino(C1-C6 alkyl), —NHCO(C1-C6 alkyl), —NHCONH2, —NHCONH(C1-C6 alkyl), —OCO(C1-C6 alkyl), and —NHCO(C1-C6 alkoxy);
R28 is selected from the group consisting of hydrogen, halogen, C1-C6 alkyl, C1-C6 haloalkyl, —NH2, —NH(C1-C6 alkyl), —N(C1-C6 alkyl)2, —OH, C1-C6 alkoxy, C1-C6 haloalkoxy, —SH, —S(C1-C6 alkyl), hydroxy(C1-C6 alkyl), alkoxy(C1-C6 alkyl), and amino(C1-C6 alkyl);
R29 is C1-C6 alkyl or C1-C6 haloalkyl; and
each R11 is independently selected from the group consisting of halogen, —NO2,—CN, C1-C6 alkyl, C1-C6 haloalkyl, —NH2, —NH(C1-C6 alkyl), —N(C1-C6 alkyl)2, —OH, C1-C6 alkoxy, and C1-C6 haloalkoxy.

US Pat. No. 10,189,785

HETEROCYCLIC COMPOUND

Takeda Pharmaceuticals Co...

1. A compound represented by a formula:
wherein
ring Ar represents an optionally further substituted aromatic heterocycle or an optionally further substituted C6-14 aromatic hydrocarbon ring;
ring A represents an optionally further substituted C6-14 aromatic hydrocarbon ring or an optionally further substituted heterocycle;
R1 represents an optionally substituted C6-14 aryl group, an optionally substituted C3-10 cycloalkyl group or an optionally substituted heterocyclic group
except that when R1 is an optionally substituted heterocyclic group, R1 is represented by a formula:

wherein ring B represents an optionally further substituted heterocycle, and
[Formula 3]

represents a single bond or a double bond, or a formula:

wherein ring D represents an optionally further substituted nitrogen-containing heterocycle,
R2 represents a hydrogen atom, or
R1 and R2 are bonded to each other to form an optionally substituted 5- or 6-membered aromatic heterocycle or an optionally substituted benzene ring
or a salt thereof.

US Pat. No. 10,189,784

N-(5-((ARYL OR HETEROARYL)METHYLOXY)PENTYL)-SUBSTITUTED IMINOSUGARS AS INHIBITORS OF GLUCOSYLCERAMIDE SYNTHASE

ACADEMISCH MEDISCH CENTRU...

1. A compound of general structure I or Ia:
wherein:
each of R19-R26 is independently selected from H, F, Me or Et;
R27 and R28 is independently selected from the group consisting of H, F, CF3 and C1-C8 linear or branched alkyl;
X is:

wherein
Y1-Y5 are independently selected from the group of C and N-atoms provided that not more than two of Y1-Y5 are a N-atom, and provided that if one or two of Y1-Y5 is a N-atom, the R-group attached to that N-atom is void;
Y6-Y9 are independently selected from the group of C-, S-, N- and O-atoms and comprise at least one of an S-, N- or O-atom, provided that Y6-Y9 comprises at most one S-atom, at most one N-atom and/or at most one O-atom, and provided that if one of Y6-Y9 is a S- or
O-atom, the R-group attached to any S-, N- and/or O-atom is void, and provided that if none of Y6-Y9 is a S- or O-atom, the R-group attached to any N-atom is selected from the group consisting of H, C1-C8 linear or branched alkyl, IV and V, and provided that O and S-atoms are not concomitantly present;
one of R1-R9 is

and the remaining of R1-R9 are independently selected from the group consisting of H, F, Cl, Br, I, CN, CF3, C1-C8 linear or branched alkyl and C1-C8 linear or branched oxyalkyl;
wherein
Y10-Y14 are independently selected from the group of C- and N-atoms provided that not more than two of Y10-Y14 are a N-atom, and provided that if one or two of Y10-Y14 is a N-atom, the R-group attached to that N-atom is void;
Y15-Y18 are independently selected from the group of C-, S-, N- and O-atoms and Y19 is selected from the group consisting of a C-atom and a N-atom, provided that Y15-Y19 comprises at most one S-atom, at most one N-atom and/or at most one O-atom, provided that if one of Y15-Y19 is a S- or O-atom, the group attached to any S-, N and/or O-atom is void, and provided that if none of Y15-Y19 is a S- or O-atom, the group attached to any N-atom is selected from the group consisting of H or C1-C8 linear or branched alkyl, and provided that O and S-atoms are not concomitantly present;
R10-R18 are independently selected from the group consisting of H, F, Cl, Br, I, CN, CF3, C1-C8 linear or branched alkyl or C1-C8 linear or branched oxyalkyl, and/or wherein two of R10-R18 form a linear or branched fused alkylene or alkylenedioxy ring on two adjacent atoms of Y10-Y18;
or a pharmaceutically acceptable salt, ester, hydrate, and/or solvate thereof.

US Pat. No. 10,189,783

POLYFUNCTIONAL COMPOUNDS

DSM IP ASSETS B.V., Heer...

1. An imide compound according to any one of formulas Ia, Ib, Ic, Id or Ie:
wherein R1 is H, methyl, hydroxymethyl, 1-hydroxyethyl, isopropyl, sec-butyl, 2-methyl-propyl, 2(methylthio)ethyl, benzyl, tolyl, parahydroxytolyl, or an organic fragment of an amino acid selected from the group consisting of arginine, histidine, lysine, aspartic acid, glutamic acid, serine, threonine, asparagine, glutamine, cysteine, selenocysteine, glycine, proline, alanine, valine, isoleucine, methionine, phenylalanine, tyrosine and tryptophan;
both R2 and R5 are a COOH group or one of R2 and R5 is a COOH group while another of R2 and R5 is H, methyl or an ethyl group;
R3 and R4 are independently H or a C1-C20 hydrocarbon group;
R6 is H or a methyl group; and
R7 and R8 are independently H, methyl or ethyl.

US Pat. No. 10,189,782

DERIVATIVES OF INDOLE FOR THE TREATMENT OF CANCER, VIRAL INFECTIONS AND LUNG DISEASES

BIOKINESIS, Paris (FR) C...

1. A compound of formula (I):
wherein:
X represents a nitrogen atom, or a N+-O— unit;
R1 and R1? are such that one is H and the other represents a halogen or one —NR11R12 unit wherein R11 and R12 represent H or a (C1-C6)alkyl group;
R2 represents:
a radical (C1-C6)alkoxy, (C3-C6)cycloalkoxy, aryloxy, (C1-C6)alkyl-aryloxy, said radical being optionally substituted with halogen, or a radical thio-(C1-C6)alkyl, thio-aryl, or thio-(C1-C6)alkyl-aryl, said radical being optionally substituted with halogen or a (C1-C6)alkoxy group;
a —NR4R5 unit, a O—(C1-C6)alkyl-NR4R5 unit or a S—(C1-C6)alkyl-NR4R5 unit wherein R4 and R5 represent II or a (C1-C6)alkyl group, with the proviso that at least one among R4 and R5 is not H;
a NHCOR6 unit wherein R6 represents (C1-C6)alkyl group;
an aryl group, optionally substituted with a halogen, a trifluoromethyl group, or a (C1-C3)alkoxy group; or
a halogen;
and
R3 represents a hydrogen, a (C1-C3)alkyl group, a (C1-C3)alkoxy group or a halogen;
and the compounds of formula (I), in which the nitrogen atom of the indole core is substituted by a group selected from the group consisting of a COR7 and a CO2R7 group, wherein R7 represents:
a (C1-C6)alkyl group, optionally substituted by at least a hydroxy group, a (C1-C6)alkyloxy group, a (C1-C6)npolyalkyloxy group wherein n is 1 a (C1-C6)alkyl group;
an aryl or a (C1-C6)alkylaryl;
a —NR9R10 unit wherein R9 and R10 represent a hydrogen or a (C1-C6)alkyl group;
a NH—NR9R10 unit wherein R9 and R10 are as defined above;
or a pharmaceutically acceptable salt thereof.

US Pat. No. 10,189,781

ONIUM SALT AND COMPOSITION COMPRISING THE SAME

ASAHI KASEI E-MATERIALS C...

1. A composition comprising:an onium salt comprising a compound A represented by the general formula (1):

wherein R1 and R2 each represent a group selected from the group consisting of hydrogen, an alkyl group, a hydroxy group, a carboxyl group, an alkoxy group, an aryloxy group, an alkylcarbonyl group, an arylcarbonyl group, an aralkylcarbonyl group, an alkoxycarbonyl group , an aryloxycarbonyl group, an alkyl group, an aralkyl group, an aryloxycarbonyl-group, an aralkyloxycarbonyl group, an alkylcarbonyloxy group, an arylcarbonyloxy group, an aralkylcarbonyloxy group, an alkoxycarbonyloxy group, an aryloxycarbonyloxy group, an aralkyloxycarbonyloxy group, an arylthiocarbonyl group, an arylthio group, an alkylthio group, an aryl group, a heterocyclic hydrocarbon group, an alkylsulfmyl group, an arylsulfmyl group, an alkylsulfonyl group, an arylsulfonyl group, a hydroxy(poly)alkyleneoxy group, an optionally substituted amino group, a cyano group, and a nitro group, and are the same or different from each other;
R3, R4, and R5 each represent a group selected from the group consisting of an aryloxy group, an arylcarbonyl group, an aralkylcarbonyl group, an aryloxycarbonyl group, an aralkyl group, an aralkyloxycarbonyl group, an alkylcarbonyloxy group, an arylcarbonyloxy group, an aralkylcarbonyloxy group, an aryloxycarbonyloxy group, an aralkyloxycarbonyloxy group, an arylthiocarbonyl group, an arylthio group, an aryl group, an alkylsulfmyl group, an arylsulfinyl group, and an arylsulfonyl group;
X is sulfur;
n represents an integer of 0 to 3;
m represents an integer of 1 to 4;
n and m satisfy n+m<4; and
R6 represents an atomic group capable of forming a monovalent anion; and
wherein the R6 is one group selected from the group consisting of SbY6?, PY6?, AsY6?, BY4?, and CY3SO3? (wherein Y represents at least one selected from the group consisting of a hydrogen atom, an alkyl group, Cl, Br, and I), or is represented by the following general formula (3):

wherein each Y? represents a hydrogen atom, a halogen atom, or an alkyl group, and at least one of the Y? is a halogen atom;
an onium salt comprising a compound B represented by the general formula (2):
wherein R7 and R8 each represent a group selected from the group consisting of hydrogen, an alkyl group, a hydroxy group, a carboxyl group, an alkoxy group, an aryloxy group, an alkylcarbonyl group, an arylcarbonyl group, an aralkylcarbonyl group, an alkoxycarbonyl group, an aryloxycarbonyl group, an aralkyl group, an aralkyloxycarbonyl group, an alkylcarbonyloxy group, an arylcarbonyloxy group, an aralkylcarbonyloxy group, an alkoxycarbonyloxy group, an aryloxycarbonyloxy group, an aralkyloxycarbonyloxy group, an arylthiocarbonyl group, an arylthio group, an alkylthio group, an aryl group, a heterocyclic hydrocarbon group, an alkylsulfinyl group, an arylsulfinyl group, an alkylsulfonyl group, an arylsulfonyl group, a hydroxy(poly)alkyleneoxy group, an optionally substituted amino group, a cyano group, and a nitro group, and are the same or different from each other;R9 represents a group selected from the group consisting of an aryloxy group, an arylcarbonyl group, an aralkylcarbonyl group, an aryloxycarbonyl group, an aralkyl group, an aralkyloxycarbonyl group, an alkylcarbonyloxy group, an arylcarbonyloxy group, an aralkylcarbonyloxy group, an aryloxycarbonyloxy group, an aralkyloxycarbonyloxy group, an arylthiocarbonyl group, an arylthio group, an aryl group, an alkylsulfinyl group, an arylsulfinyl group, and an arylsulfonyl group;
R10 represents an atomic group capable of forming a monovalent anion; andwherein the R10 is one group selected from the group consisting of SbY6?, PY6?, AsY6?, BY4?, and CY3SO3? (wherein the Y represents at least one selected from the group consisting of a hydrogen atom, an alkyl group, Cl, Br, and I), or is represented by the following general formula (3):
wherein each Y? represents a hydrogen atom, a halogen atom, or an alkyl group, and at least one of the Y? is a halogen atom.

US Pat. No. 10,189,780

BICYCLIC ALKYL COMPOUNDS AND SYNTHESIS

1. A compound having the structure of Formula (I):
wherein:
R1 is N3, SCN, NO, —C(?NOR2)(CN), or —CH(?NOR2), and
R2 is (C1 to C10) alkoxy, substituted or unsubstituted (C1 to C30) alkyl, substituted or unsubstituted aryl, substituted or unsubstituted alkenyl, substituted or unsubstituted alkynyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl, substituted or unsubstituted cycloalkynyl, substituted or unsubstituted heterocycle, substituted or unsubstituted heteroaryl, substituted or unsubstituted aryl(alkyl), substituted or unsubstituted alkyl(aryl), or substituted or unsubstituted heteroaryl(alkyl).

US Pat. No. 10,189,777

BENZENESULFONAMIDO AND RELATED COMPOUNDS FOR USE AS AGONISTS OF ROR? AND THE TREATMENT OF DISEASE

Lycera Corporation, Ann ...

1. A compound represented by Formula I:
or a pharmaceutically acceptable salt thereof; wherein:
A is phenylene, 5-6 membered heteroarylene, or C3-6 heterocycloalkylene;
R1 represents independently for each occurrence halogen, C1-6 alkyl, C1-6 haloalkyl, or C3-6 cycloalkyl;
R2 is C1-6 alkyl optionally substituted with 1, 2, or 3 substituents independently selected from the group consisting of halogen, hydroxyl, and C1-6 alkoxy;
R3 is C1-6 haloalkyl;
R4 represents independently for each occurrence hydrogen, C1-6 alkyl, or C3-6 cycloalkyl;
X is one of the following:
(i) —O-aralkyl, —O-heteroaralkyl, —O-phenyl, —O-heteroaryl, —O-(partially unsaturated bicyclic carbocyclyl), —O—(C1-6 alkylene)—(C3-6 cycloalkyl), —O—(C3-6 cycloalkyl), —N(R4)-aralkyl, —N(R4)-phenyl, —N(R4)-(partially unsaturated bicyclic carbocyclyl), or —N(R4)—(C 1-6 alkylene)—(C3-6 cycloalkyl), each of which is optionally substituted with 1, 2, or 3 substituents independently selected from the group consisting of halogen, C1-6 haloalkyl, C1-6 alkyl, C3-6 cycloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, hydroxyl, and cyano;
(ii) —(C2-6 alkenylene)-phenyl, —(C2-6 alkenylene)-heteroaryl, —(C1-6 alkylene)-phenyl, —(C1-6 alkylene)-heteroaryl, —(C1-6 alkylene)-(partially unsaturated bicyclic heterocyclyl), —(C1-6 alkylene)-(partially unsaturated bicyclic oxo-heterocyclyl), -(5-6 membered heterocycloalkylene)-phenyl, or —(C3-6 cycloalkylene)-phenyl, each of which is optionally substituted with 1, 2, or 3 substituents independently selected from the group consisting of halogen, C1-6 haloalkyl, C1-6 alkyl, C3-6 cycloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, hydroxyl, and cyano; or
(iii) —(C1-6 alkylene)-Z1 or —(C2-6 alkenylene)-Z1, wherein Z1 is —O-aralkyl, —O-heteroaralkyl, —O-phenyl, —O-heteroaryl, —O-(partially unsaturated bicyclic carbocyclyl), —O—(C1-6 alkylene)—(C3-6 cycloalkyl), —O—(C3-6 cycloalkyl), —N(R4)-aralkyl, —N(R4)-phenyl, —N(R4)-(partially unsaturated bicyclic carbocyclyl), —N(R4)—(C1-6 alkylene)—(C3-6 cycloalkyl), or —N(R4)—(C3-6 cycloalkyl), each of which is optionally substituted with 1, 2, or 3 substituents independently selected from the group consisting of halogen, C1-6 haloalkyl, C1-6 alkyl, C3-6 cycloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, hydroxyl, and cyano;
m is 0, 1, or 2; and
n is 1, 2, or 3.

US Pat. No. 10,189,775

CARBOCYCLIC COMPOUNDS AS ROR GAMMA MODULATORS

GLENMARK PHARMACEUTICALS ...

1. A compound of formula (I)or a tautomer thereof, stereoisomer thereof or pharmaceutically acceptable salt thereof,whereinR1 is selected from amino, hydroxyl, C1-8alkyl and C1-8alkoxy;
R2 is selected from C1-8alkyl, haloC1-8alkyl, hydroxyC1-8alkyl, C3-6cycloalkyl and C3-6cycloalkylC1-8alkyl;
R3 is selected from hydrogen, C1-8alkyl, haloC1-8alkyl and hydroxyC1-8alkyl;
R4 is selected from C1-8alkyl, C1-8alkoxy, haloC1-8alkyl, hydroxyC1-8alkyl, C3-6cycloalkyl and C3-6cycloalkylC1-8alkyl;
each occurrence of R5 is independently selected from halogen, hydroxyl, cyano, C1-8alkyl, C1-8alkoxy, haloC1-8alkyl, haloC1-8alkoxy, hydroxyC1-8alkyl, C3-6cycloalkyl and optionally substituted C6-14aryl, wherein the substitution on C6-14aryl is halogen;
each occurrence of R6 is independently selected from halogen, cyano, hydroxyl, C1-8alkyl and C3-6cycloalkyl;
Ra and Rb , which may be same or different, are each independently selected from hydrogen and C1-8alkyl; or Ra and Rb together may form an oxo group;
‘n’ is 1, 2, 3 or 4;
‘m’ is 0, 1 or 2; and
‘p’ is 0 or 1.

US Pat. No. 10,189,773

IN-VIVO GELLING PHARMACEUTICAL PRE-FORMULATION

MEDICUS BIOSCIENCES, LLC,...

1. An in vivo gelling pharmaceutical pre-formulation, comprising:(a) at least one multifunctional nucleophilic monomer comprising a polyol core, wherein the polyol core is selected from the group consisting of:
andwherein R is:

wherein n is 10-200 and the molecular weight of the nucleophilic monomer is between about 2,000 to about 40,000;
(b) at least one water soluble second compound comprising more than one electrophilic group selected from an epoxide, N-succinimidyl succinate, N-succinimidyl glutarate, N-succinimidyl succinamide or N-succinimidyl glutaramide, wherein the second compound comprising the core of one electrophilic group is a pentaerythritol, and wherein the second compound further comprises one or more polyethylene glycol sections; and
(c) an aqueous buffer in the pH range of 5.0 to 9.0;wherein mixing a mixture comprising the at least one multifunctional nucleophilic monomer and the at least one water soluble second compound in the aqueous buffer and delivering the mixture to a target site in the human body generates the in vivo gelling pharmaceutical pre-formulation such that the in vivo gelling pharmaceutical pre-formulation at least in part polymerizes and gels at the target site to form a biocompatible hydrogel polymer, and wherein the in vivo gelling pharmaceutical pre-formulation does not contain blood or protein.

US Pat. No. 10,189,771

ACRYLIC ADHESIVE COMPOSITION FROM PROTECTED PHOTOCROSSLINKING AGENTS

3M Innovative Properties ...

1. A protected photocrosslinker of the formula:
wherein
R1 is H or CH3;
each of X1 and X2 is —O— or —NR1—;
R2 is a divalent (hetero)hydrocarbyl group;
subscript a is 0 or 1;
Prot is a carbonyl protecting group;
R3 is selected from:

wherein each R4 is H or a C1 to C6 alkyl group, R5 is independently a hydroxyl group, a phenyl group, a C1 to C6 alkyl group, or a C1 to C6 alkoxy group.