US Pat. No. 10,507,190

METHOD FOR TREATING HYPERHIDROSIS WITH DEXMECAMYLAMINE

Atacama Therapeutics, Inc...

1. A method of treating hyperhidrosis, the method comprising the administration of a therapeutically effective amount of dexmecamylamine or a pharmaceutically acceptable salt thereof, substantially free of exo-R-mecamylamine, to a subject with hyperhidrosis.

US Pat. No. 10,507,189

ANALGESIC COMPOSITIONS

Vapogenix, Inc., Houston...

1. An uniform composition comprising a halogenated volatile compound and hydroxypropyl cellulose (HPC);wherein the halogenated volatile compound is selected from the group consisting of isoflurane, halothane, enflurane, sevoflurane, desflurane, methoxyflurane, and any mixtures thereof.

US Pat. No. 10,507,168

MUSICAL TEETHER

KAR KOI LEUNG, Hong Kong...

9. A teether comprising a body member, a musical unit removably engageable with the body member and a transmitter for transmitting vibrational musical signal from the musical unit to the body member for onward transmission to teeth of the infant, wherein the transmitter is generally elongate in profile with enlarged opposite ends and narrower middle region, and is disposed in a conduit in the body member and is in abutment with the musical unit and the outer portion at the opposite ends, wherein the middle region of the transmitter is not in contact with walls defining the conduit of the teether for facilitating transmission of vibrational musical signal.

US Pat. No. 10,507,161

BACK PLATES FOR MECHANICAL CPR COMPRESSION

JOLIFE AB, Lund (SE)

1. A back plate (100?) for use with a cardiopulmonary resuscitation (CPR) compression device, comprising:a top surface (102?);
first and second sides (106?, 108?);
third and fourth sides (118?);
first and second static attachment elements (112?), wherein the first static attachment element is configured on the first side to releasably connect to a first leg of the CPR compression device, and the second static attachment element is configured on the second side to releasably connect to a second leg of the CPR compression device;
a bottom surface (104?) comprising a plurality of ribs (116?) that run from the first side to the second side in parallel to the third and fourth sides; and
at least two anti-slip surfaces adhered to the ribs;
wherein the back plate includes a hollow portion between the top and bottom surfaces and the first, second, third, and fourth sides, and wherein the ribs and third and fourth sides provide structural rigidity to the back plate.

US Pat. No. 10,507,159

CUSTOM MASSAGE PROGRAMMING USING TOUCHSCREEN INTERFACE

Ford Global Technologies,...

1. A massage system, comprising: a seat having a first surface;a first massage assembly beneath the first surface and including a first matrix of inflatable bladders;
an interface including a touchscreen displaying an image of the first matrix on the touchscreen and receiving a touch input;
a processor interpreting the touch input as an indication of a desired massage sequence; and
a controller causing the first massage assembly to implement the desired massage sequence,
wherein the touch input is in the form of a continuous, moving touch over an area of the touchscreen on which the image of the first matrix is displayed; and
the processor interprets the touch input as the indication of the desired massage sequence by defining the continuous moving touch as a line over the image of the first matrix and including ones of the bladders contacted or intersected by the line in the massage sequence;
wherein the processor further interprets the touch input as the indication of the desired massage sequence by matching sequence of inflation and deflation of the ones of the bladders included in the massage sequence with a direction of movement of the continuous, moving touch input.

US Pat. No. 10,507,155

TREMOR SUPPRESSION APPARATUS AND METHOD USING SAME

1. A method of suppressing a tremor comprising:a) providing a neuromuscular plasticity apparatus comprising:
i) a rotational drive device that rotates a coupler about a rotational axis and the rotational drive device has a first user interface that moves at a drive amplitude and drive frequency; wherein the first user interface is coupled to the rotational drive device by said coupler; said coupler comprising: a drive end that is connected with the rotational drive device; a user interface end; an offset portion between the drive end and the first user interface that offsets the first user interface from the rotational axis of the rotational drive device to produce an offset radius distance of the first user interface that creates an orbital path of the first user interface when the rotational drive device rotates the coupler; wherein the offset radius distance is no more than 25 mm; and in use, the neuromuscular plasticity apparatus is coupled to said user's limb to produce a forced motion of said user's limb in a direction of the user's tremor;
b) measuring a user's tremor frequency;
c) coupling the first user interface with said user's limb;
d) setting the drive frequency of the rotational drive device to be substantially the same as said user's measured tremor frequency, within 50% of the said user's measured tremor frequency; and
e) moving the first user interface by rotating the coupler about said rotational axis at said drive amplitude of no more than 25 mm and said drive frequency of at least 3 Hz but no more than 30 Hz to drive said user's limb at substantially said user's measured tremor frequency, wherein the drive frequency is within about 50% of said measured tremor frequency.

US Pat. No. 10,507,151

PATIENT SUPPORT APPARATUS WITH SIDE RAIL

Stryker Corporation, Kal...

1. A patient support apparatus comprising:a frame;
a side rail mounted to said frame, said side rail including a side rail body and a pair of arms mounting said side rail body for movement over a full range of motion relative to said frame, said pair of arms having a first pair of pivot connections connected to said side rail body and a second pair of pivot connections for mounting to said frame;
a timing link; and
said first pair of pivot connections engaging said timing link, and each of said first pair of pivot connections and said timing link being located within said outer perimeter of said side rail body over said full range of motion of said side rail body.

US Pat. No. 10,507,149

NURSING BED AND CONTROL METHOD THEREOF

BOE TECHNOLOGY GROUP CO.,...

1. A nursing bed, comprising:a bed body, provided with a plurality of combined bed boards, at least one of the plurality of combined bed boards is provided with one or more pressure sensors;
a comparator, connected to the one or more pressure sensors, and configured to compare pressure data transmitted by the one or more pressure sensors with a predetermined pressure value and output a warning signal when the pressure data transmitted by the one or more pressure sensors is greater than or equal to the predetermined pressure value;
a timer, connected to the comparator, and with respect to each of the pressure sensors, configured to start timing when the warning signal is received and output an alarm signal when a preset time is reached;
an alarm device, connected to the timer, and configured to give an alarm after the alarm signal is received,
a plurality of liftable rods, corresponding to the plurality of combined bed boards in a one-to-one correspondence relation, and each of the plurality of liftable rods is fixed at a lower surface of the corresponding combined bed board;
a combined bed board controller, connected to the comparator, and configured to determine the combined bed board corresponding to the warning signal upon receiving the warning signal and generate a moving downward control signal; and
a combined bed board driving motor, connected to the liftable rods and the combined bed board controller, and configured to drive a liftable rod of the combined bed board that corresponds to the warning signal to move downward according to the moving downward control signal.

US Pat. No. 10,507,148

POWERED DRIVE BED SYSTEMS AND METHODS

KAP Medical, Inc., Coron...

1. A bed adapted to be supported on a floor, comprising:a plurality of wheels;
a frame supported by the plurality of wheels, the frame having a top surface;
a headboard and a footboard, the footboard spaced apart from the headboard, the headboard and the footboard supported by the plurality of wheels;
a support deck supported by the plurality of wheels, the support deck including a head end positioned proximate the headboard and a foot end positioned proximate the footboard, and at least one support surface extending between the head end of the support deck and the foot end of the support deck; and
a powered drive system coupled to the frame, the powered drive system including:
a drive system frame;
a drive wheel coupled to the drive system frame and moveable between a raised position and a lowered position, wherein in the lowered position the drive wheel is adapted to contact the floor,
a motor operatively coupled to the drive wheel to power a rotation of the drive wheel,
a suspension operatively coupled to the drive wheel, the suspension biasing the drive wheel downward when the drive wheel is in the lowered position while permitting an upward movement of the drive wheel; and
a linear actuator operatively coupled to the drive wheel, the linear actuator having a first length to position the drive wheel in the raised position and a second length to position the drive wheel in the lowered position, the linear actuator maintaining a first orientation relative to the top surface of the frame as the drive wheel is moved between the raised position and the lowered position.

US Pat. No. 10,507,146

SITTING TO STANDING LIFT CHAIR

1. A sitting to standing lift chair, comprising:a base having a base platform;
a bottom elevated platform, the bottom elevated platform having a bottom surface, a top surface, a front edge, and a rear edge;
an electromechanical chair height adjustment mechanism supporting the bottom elevated platform on the base platform
a seat bottom, the seat bottom having a bottom surface, a top surface, a front edge, and a rear edge;
an electromechanical sitting to standing mechanism supporting the seat bottom on the bottom elevated platform;
a seat back and a seat back hinge rotatably attaching the seat back to the rear edge of the seat bottom, the seat back having a bottom edge, a top edge, a right edge, a left edge, a front surface, and a rear surface;
a first chair height adjustment switch electrically connected to the electromechanical chair height adjustment mechanism for actuating the chair height adjustment mechanism, the first switch having a neutral position, an up position activating the electromechanical chair height adjustment mechanism to raise the bottom elevated platform relative to the base platform, and a down position activating the electromechanical chair height adjustment mechanism to lower the bottom elevated platform relative to the base platform; and
a second sitting to standing switch electrically connected to the electromechanical sitting to standing mechanism for actuating the sitting to standing mechanism, the second switch having a neutral position, an up position actuating the electromechanical sitting to standing mechanism to raise and rotate the seat bottom relative to the elevated platform and to raise the seat back relative to the elevated platform toward a standing position of the sitting to standing lift chair, and a down position actuating the electromechanical sitting to standing mechanism to lower and rotate the seat bottom relative to the elevated platform and to lower the seat back relative to the elevated platform toward a seating position of the sitting to standing lift chair.

US Pat. No. 10,507,145

POWERED PATIENT SUPPORT APPARATUS

Stryker Corporation, Kal...

1. A patient support apparatus comprising:a base having a plurality of wheels;
a patient support deck supported by said base, said patient support deck adapted to support a patient;
a first motor adapted to provide power to a powered wheel, the powered wheel being one of the plurality of wheels;
a second motor adapted to steer a steered wheel, the steered wheel being one of the plurality of wheels;
a sensor adapted to detect a person positioned off-board the patient support apparatus; and
a controller adapted to control a direction and speed of the patient support apparatus using the first and second motors, respectively, such that movement of the patient support apparatus across a floor matches walking movement of the person.

US Pat. No. 10,507,141

APPARATUSES AND METHODS FOR NEGATIVE PRESSURE WOUND THERAPY

1. An apparatus to provide suction to a wound site comprising:a wound dressing comprising:
an absorbent layer for absorbing wound exudate from the wound site,
a transparent cover layer overlying the absorbent layer and extending over the entirety of the absorbent layer, the transparent cover layer_comprising an opening; and
an obscuring layer between the absorbent layer and the transparent cover layer that at least partially obscures visualization of the absorbent layer from above the transparent cover layer;
a fluidic connector attached to the wound dressing comprising:
a spacer layer comprising a proximal end, an elongate middle portion, and a distal end;
a transparent top layer constructed from a liquid impermeable material provided over the spacer layer, the transparent top layer defining an upper surface of the fluidic connector;
a bottom layer constructed from a liquid impermeable material provided below the spacer layer, wherein the transparent top layer and the bottom layer are sealed together around a perimeter thereof to enclose the spacer layer and wherein the spacer layer is in contact with the transparent top layer and the bottom layer; and
one or more apertures in the bottom layer beneath the distal end of the spacer layer, wherein a distal end of the bottom layer of the fluidic connector is positioned over the transparent cover layer of the wound dressing with the one or more apertures in the bottom layer being positioned over the opening in the transparent cover layer; and
a portion of absorbent material positioned below the distal end of the spacer layer, wherein the portion of absorbent material is visible around an outer perimeter of the spacer layer of the fluidic connector through the transparent top layer of the fluidic connector and is configured to indicate saturation of the absorbent layer by the wound exudate.

US Pat. No. 10,507,139

WOUND DRESSING APPARATUS AND METHOD OF USE THEREOF

FIRST CARE PRODUCTS LTD.,...

1. A wound-dressing apparatus, the apparatus comprising:an elongated wrapping element; and
a foldable pad element;
wherein said pad element comprises a first portion attached to a second portion, each portion comprising at least one absorbent layer;
wherein at least part of said first portion is attached to a first surface of said wrapping element such that said at least one absorbent layer faces away from said first surface;
wherein said second portion is configured to have an open position and a closed position, such that when said second portion is in the open position, said at least one absorbent layer faces away from the first surface of said wrapping element;
wherein said second portion is configured to be removed from said first portion, and
wherein said second portion extends beyond said first portion and said first surface of the wrapping element when in said open position.

US Pat. No. 10,507,137

TACTILE INTERFACE SYSTEM

1. A directional information communication system comprising:a first unit configured to be worn at a first ear of a user, the first unit comprising a first tactile output device configured to deliver a tactile output to the first ear, wherein said tactile output to the first ear is operable to produce a tactile sensation at the first ear of the user;
a second unit configured to be worn at a second ear of the user, the second unit comprising a second tactile output device configured to deliver a tactile output to the second ear, wherein said tactile output to the second ear is operable to produce a tactile sensation at the second ear of the user; and
a processor configured to cause tactile output from at least one of the first and second tactile output devices according to directional information received by the directional information communication system such that a direction is operable to be communicated to the user through said tactile sensation at the first ear of the user and said tactile sensation at the second ear of the user, wherein said direction corresponds to said directional information received by the directional information communication system.

US Pat. No. 10,507,134

SYSTEMS AND METHODS FOR PULSED POSTERIOR VITREOUS DETACHMENT CREATION

Novartis AG, Basel (CH)

1. A method of performing a posterior vitreous detachment, the method comprising:receiving a command from a user of a surgical system to initiate a detachment process;
wherein the surgical system comprises a surgical console and a handpiece fluidly coupled to the surgical console;
wherein the surgical console comprises a fluid reservoir; and
wherein the handpiece comprises a handle portion configured to be grasped by a user and a flexible elongate lumen coupled to a distal end of the handle portion;
forcing a first pulse of fluid from the fluid reservoir through the flexible elongate lumen to a surgical site to separate a vitreous from a retina; and
forcing a second pulse of the fluid from the fluid reservoir through the flexible elongate lumen to the surgical site to further separate the vitreous from the retina, without repositioning the handpiece between the first and second pulses.

US Pat. No. 10,507,123

SELF-EXPANDABLE SCAFFOLDING DEVICE FOR THE TREATMENT OF ANEURYSMS

MONARCH BIOSCIENCES, INC....

1. A stent comprising:a first longitudinally extended cylinder having a C-shaped cross-section, the first cylinder comprising a plurality of first longitudinal struts and an array of first radial struts extending between the first longitudinal struts; and
a second longitudinally extended cylinder having a C-shaped cross-section, the second cylinder comprising a plurality of second longitudinal struts and an array of second radial struts extending between the second longitudinal struts;
wherein the first cylinder and the second cylinder are configured to form a dense mesh when assembled, and
wherein the first and second longitudinally extended cylinders further comprise S-shaped struts that connect to and extend from a corresponding longitudinal central strut towards a corresponding longitudinal edge strut, curve around to extend towards the corresponding central strut, and curve around to extend to and connect to the corresponding edge strut.

US Pat. No. 10,507,120

SYSTEMS AND METHODS FOR PERFORMING SURGICAL PROCEDURES AND ASSESSMENTS

NuVasive, Inc., San Dieg...

1. A spinal access cannula comprising:a dilating cannula having an outer surface with a continuous cross section from a proximal end to a distal end of the dilating cannula except for a tapered portion near the distal end that tapers to a smaller diameter toward the distal end and having an inner surface defining an inner lumen extending from the proximal end to the distal end, the distal end of the dilating cannula having a distal central opening therethrough in communication with the inner lumen and in line with a central longitudinal axis of the dilating; and
a single stimulation electrode fixed at the tapered portion and on the outer surface of the dilating cannula, and exposed at only a radial portion of the outer surface of the dilating cannula, wherein the radial portion comprises an arc on the outer surface of the dilating cannula, wherein the length of the arc is less than the circumference of the outer surface of the dilating cannula, wherein all other portions of the distal end of the dilating cannula has no exposed stimulation electrode.

US Pat. No. 10,507,115

DYNAMIC SPINAL SEGMENT REPLACEMENT

MEDSMART INNOVATION, INC....

1. A vertebral implant assembly comprising:a prosthetic vertebral body for insertion into a spinal column, said prosthetic vertebral body having a fastener receiving member pivotally attached to the prosthetic vertebral body;
a pedicle fastener having at least two distinct fastening portions, said distinct fastening portions comprising a first fastening portion receivable by the fastener receiving member of the prosthetic vertebral body, and a second fastening portion configured to fasten to cancellous bone,
wherein both the first and second fastening portions are threaded, and wherein the thread of the first fastening portion is finer than the thread of the second fastening portion,
wherein the pedicle fastener has a central aperture running along an axis through each fastening portion for receiving a guide wire therethrough.

US Pat. No. 10,507,113

REVERSE TOTAL HIP REPLACEMENT

1. A method for a total reverse hip replacement comprising:a) implanting an acetabular base that is formed as a spherical segment having a spherical interface surface that extends between a first flat surface and a second flat surface parallel to the first flat surface and having fastener tunnels that extend in parallel to the first and second flat surfaces and through a bridge portion of the acetabular base, by:
i) reaming a human acetabulum to reach cancellous bone using a series of reamers of increasing diameter, each reamer having a surface comprising a partial spherical shell and an open apex formed to preserve thickness of a medial acetabular wall;
ii) orienting the fastener tunnels of the acetabular base to define an anterior-to-posterior fastener trajectory within the acetabulum;
iii) press-fitting the acetabular base into the acetabulum, according to the defined anterior-to-posterior fastener trajectory;
iv) fastening the acetabular base to the acetabulum;
b) fixing a substantially hemispheric acetabular ball into the acetabular base;
c) implanting, into a transected femur, a femoral stem portion of a femoral component, wherein the femoral component further comprises a cup-shaped portion; and
d) fitting the cup-shaped portion of the femoral component against the surface of the acetabular ball.

US Pat. No. 10,507,112

IMPLANT ANCHORING DEVICE

Zimmer, Inc., Warsaw, IN...

1. A method of delivering an anchor assembly into a bone, comprising:threading an elongated porous anchor into a bone until a leading end of the elongated porous anchor is positioned inside the bone and a trailing end of the elongated porous anchor is positioned at or beneath an outer surface of the bone, wherein said threading leaves a top exterior surface of the elongated porous anchor exposed along the outer surface of the bone, the top exterior surface being porous for receiving tissue ingrowth, wherein the elongated porous anchor includes a central longitudinal axis and a cannula that extends longitudinally within the elongated porous anchor along the central longitudinal axis, and wherein the elongated porous anchor includes an exterior thread that is made entirely of a highly porous metal material having a porosity of between 55% and 90%;
positioning soft tissue in contact with the top exterior surface of the elongated porous anchor after said threading so that the soft tissue can grow into the top exterior surface; and
advancing a fastener within the cannula of the elongated porous anchor after said threading of the elongated porous anchor into the bone.

US Pat. No. 10,507,106

AORTIC INSUFFICIENCY REPAIR DEVICE AND METHOD

Edwards Lifesciences Corp...

1. A support frame configured to be implanted in a native heart valve, the support frame comprising:an inflow end and an outflow end;
a radially expandable and collapsible annular main body including a plurality of angled struts and including a plurality of apices formed by the intersection of respective adjacent struts; and
one or more pairs of clipping arms, each of the one or more pairs of clipping arms being located between two of the respective adjacent struts defining an apex of the main body, each of the clipping arms comprising a fixed end portion and a free end portion, the free end portion being offset from the apex in a direction toward the inflow end, the clipping arms defining a leaflet-receiving space between two opposing surfaces of the clipping arms for engaging portions of adjacent native leaflets of the native heart valve therebetween;
wherein the clipping arms are disposed within an outer diameter of the support frame defined by the plurality of angled struts.

US Pat. No. 10,507,101

VALVED CONDUIT

1. A valved conduit comprising:a conduit including a first conduit having a first conduit distal end and a second conduit having a second conduit proximal end, the conduit has a conduit inner surface and a conduit outer surface the first conduit distal end defining a plurality of commissure slots; and
a valve structure including at least one leaflet, each leaflet having a free edge and a leaflet attachment edge, the leaflet attachment edge disposed between the first conduit distal end and the second conduit proximal end that are coaxial therebetween defining a junction,
wherein the leaflet attachment edge is coupled between the first conduit distal end and the second conduit proximal end,
wherein the first conduit distal end, the leaflet attachment edge, and the second conduit proximal end are coupled together with suture,
wherein the first conduit distal end comprises a plurality of first conduit apertures, and wherein the second conduit proximal end comprises a plurality of second conduit apertures, wherein the leaflet attachment edge further comprises a leaflet aperture inner row including a plurality of leaflet apertures, wherein the leaflet attachment edge is disposed within the junction such that the leaflet aperture inner row is adjacent the conduit inner surface, wherein the suture passes through the leaflet apertures and extends along a conduit inner surface coupling the first conduit distal end, the leaflet attachment edge, and the second conduit proximal end together.

US Pat. No. 10,507,097

SURGICAL IMPLANT DEVICES AND METHODS FOR THEIR MANUFACTURE AND USE

Edwards Lifesciences Card...

9. An assembly, comprising:a stent member, wherein the stent member is circumferentially expandable and contractible;
an adjustment member, wherein the adjustment member is coupled to the stent member and configured for circumferentially expanding and contracting the stent member;
a rotatable shaft; and
a locking mechanism coupled to the shaft and movable between a lock configuration and a release configuration,
wherein the locking mechanism is configured to engage the adjustment member such that axial movement of the shaft results in corresponding axial movement of the adjustment member when locking mechanism is in the lock configuration, and
wherein the locking mechanism is configured to disengage the adjustment member such that the shaft can move axially relative to the adjustment member when the locking mechanism is in the release configuration.

US Pat. No. 10,507,089

IMAGING APPARATUS WITH SIMPLIFIED OPTICAL DESIGN

Align Technology, Inc., ...

1. A method of generating a three-dimensional virtual model of an intraoral object, comprising:capturing, by an imaging apparatus for performing intraoral scans, surface scan data of the intraoral object while changing a position of at least one lens of focusing optics of the imaging apparatus, wherein the surface scan data comprises depth data for a plurality of points of the intraoral object;
adjusting the depth data for one or more of the plurality of points based at least in part on the position of the at least one lens associated with the depth data for the one or more of the plurality of points using one or more compensation models, wherein the one or more compensation models compensate for changes in magnification associated with different positions of the at least one lens, and wherein the one or more compensation models provide different adjustments to the depth data for the one or more of the plurality of points for the different positions of the at least one lens; and
generating the three-dimensional virtual model of the intraoral object using the adjusted depth data.

US Pat. No. 10,507,067

NEEDLE STEERING BY SHAFT MANIPULATION

1. A system for inserting a needle into a body of a subject, and for steering said needle within soft tissue of said subject, comprising:a robotic platform having a plurality of degrees of freedom and configured to provide said needle with a desired pose; and
a needle gripper configured to be attached to said robotic platform and to grip a shaft of said needle at its distal end, said needle gripper comprising a driving mechanism configured to be activated to provide motion to said needle in the longitudinal direction of said needle, wherein
said driving mechanism comprises at least a pair of rollers on either side of said needle, such that coordinated rotation of said rollers causes said needle to move in said longitudinal direction, and
said robotic platform and said driving mechanism of said needle gripper are activated in coordination, such that said robotic platform adjusts the orientation angle of said needle inside said soft tissue of said subject during insertion motion of said needle into said subject, such that said needle traverses a non-linear path within said soft tissue of said subject.

US Pat. No. 10,507,063

VISIBLE LIGHT COMMUNICATION SYSTEM FOR TRANSMITTING DATA BETWEEN VISUAL TRACKING SYSTEMS AND TRACKING MARKERS

Think Surgical, Inc., Fr...

1. An optical tracking system for a robotic surgical device, the system comprising:the robotic surgical device having one or more processors and a photosensor in communication with at least one of said processors;
at least one tracking array coupled with said robotic surgical device and in communication with at least one of said processors, wherein said tracking array comprises a first set of at least three active light emitting diodes (LEDs), where at least one of said active LEDs is modulated to optically transmit data from one or more of said processors, and where said active LEDs concurrently or independently also emit optical signals to permit tracking of said robotic surgical device;
at least one tracker for optically receiving said optically transmitted data; and
a second active LED on said at least one tracker, where the second active LED on said at least one tracker is modulated to optically transmit operational, informational, or instructional data to be received by the photosensor and used to execute or be executed by the robotic surgical device to implement a surgical plan, and
wherein said tracking array sends said optically transmitted data in two or more modes in parallel; wherein
in at least a first mode said optically transmitted data comprising a first information is sent at a first data rate, and
in at least a second mode said optically transmitted data comprising a second information is sent at a second data rate different from the first data rate.

US Pat. No. 10,507,062

MEDICAL FASTENING DEVICE AND REFERENCING DEVICE AND MEDICAL INSTRUMENTATION

Aesculap AG, Tuttlingen ...

1. Medical fastening device for noninvasively fastening a medical marking device comprising two or more marking elements to a body part of a patient, the medical fastening device comprising:a support body which extends over a surface in two directions of extent aligned at an angle to each other and which is adaptable in shape to a contour of the body part,
the support body being elastically stretchable in a surface of extent and comprising a first stretch area and at least one second stretch area, the stretchability of the at least one second stretch area in at least one direction in the surface of the extent of the support body is less than the stretchability of the first stretch area, and
at least one holding part fixed to the first stretch area of the support body,
wherein the marking device or a marking element of the marking device is fixed or fixable with at least one of force locking and positive locking on a side of the holding part facing away from the support body.

US Pat. No. 10,507,060

SPINAL BALANCE ASSESSMENT

NuVasive, Inc., San Dieg...

1. A method for assessing spinal balance during a surgical procedure executed on a surgical site on the spine of a patient, the method comprising: uploading into a processor based working platform, at least one preoperative image of the surgical site related anatomy; identifying at least one spinal metric for assessing spinal balance selected from the group comprising: sagittal vertical axis, pelvic tilt, pelvic incidence, thoracic kyphosis, lumbar lordosis, sagittal alignment, coronal alignment, or tilt; determining a preoperative numeric value of the at least one spinal metric from the preoperative image, said determining step comprising acquiring a preoperative digital position of two or more spinal landmarks defining the spinal metric, generating one or more preoperative lines between the spinal landmarks, and determining a preoperative numeric relationship between the spinal landmarks; determining a desired reconstruction numeric value of the at least one spinal metric based on the determined preoperative numeric value, said determining step comprising identifying one or more parameters for achieving a desired correction and a desired balance; porting the identified one or more parameters to a mobile device; performing a surgical correction on the surgical site based on the identified one or more parameters; capturing at least one intraoperative image of the surgical site; uploading the at least one intraoperative image to the mobile device; determining an intraoperative numeric value of the at least one spinal metric from the intraoperative image, said determining step comprising acquiring an intraoperative digital position of two or more spinal landmarks defining the spinal metric, generating one or more intraoperative lines between the spinal landmarks, and determining an intraoperative numeric relationship between the spinal landmarks; and reconciling the intraoperative numeric value of the at least one spinal metric from the intraoperative image with the desired reconstruction numeric value of the at least one spinal metric.

US Pat. No. 10,507,056

SYSTEM AND METHOD FOR REPRESENTATION AND VISUALIZATION OF CATHETER APPLIED FORCE AND POWER

General Electric Company,...

1. A method for determining the orthogonality and applied force vector of an ablation catheter, the method comprising the steps of:providing an electrophysiology system including an RF generator; a processor operably connected to the RF generator; a display operably connected to the processor and an ablation catheter operably connected to the RF generator and the processor, the catheter including an ablation electrode disposed opposite the RF generator and forming a tip of the ablation catheter and a number of microelectrodes disposed on and electrically isolated from the ablation electrode, the processor configured to compare data signals obtained from the microelectrodes with one another to derive a difference value for each pair of data signals;
positioning the ablation electrode within the tissue to be ablated;
obtaining data signals from the microelectrodes;
comparing the data signals from microelectrode pairs to determine difference values; and
generating a visual representation on the display of the orthogonality and an applied force vector of the ablation electrode relative to the tissue using the difference values,
wherein the step of generating the visual representation comprises generating a wire form space plot, wherein the ablation electrode provided includes a number of sets of spaced microelectrodes,
wherein the step of generating the visual representation comprises generating a wire form space plot for each set of microelectrodes, and
wherein the step of generating a wire form space plot for each set of microelectrodes further comprises generating a three-dimensional representation of the tissue using the wire form space plots.

US Pat. No. 10,507,052

SYSTEM FOR HANDLING AN AUGMENTATION IMPLANT

Woodwelding AG, (CH) Str...

1. A device for handling and implanting an augmentation implant, comprising:an augmentation screw;
a plurality of polymeric augmentation pins;
an augmentation pin magazine comprising a plurality of pin-retainers for retaining the plurality of polymeric augmentation pins therein;
an ultrasound applicator comprising an ultrasound transducer and a sonotrode for engaging the plymeric augmentation pins;
an elongated housing having a distal portion, a proximal tool portion and a body portion extending along a second longitudinal axis and connecting the distal portion to the proximal tool portion, said elongate housing includes an axial through-bore extending through the proximal tool portion, the body portion and the distal screw portion of the elongated housing for accommodating the sonotrode of the ultrasound applicator for engaging the augmentation pins, and a lateral opening extending through the body portion of the elongate housing for receiving the augmentation pin magazine, wherein the axial through-bore and the lateral opening intersect each other;
wherein the distal portion distal of the housing lateral opening engages a proximal end of the augmentation screw, such that the axial through bore of the elongated housing is aligned with an axial through bore of the augmentation screw;
a closing plug insertable into the axial through bore of the augmentation screw and having a plurality of ribs on a proximal end forming channels, wherein when the closing plug is disposed within the axial bore of the augmentation screw the plug closes the axial through bore of the augmentation screw at a distal tip of the augmentation screw, and the channels are configured to redirect fluidized polymeric pins from the axial bore and out of at least one lateral through bore in the augmentation screw;
a tool mounted on a proximal portion of the housing for driving the augmentation screw, such that the distal housing portion is configured to transmit torque from the tool mounted on the proximal end of the elongated housing to the augmentation screw, for screwing in the augmentation screw into an object;
wherein the elongate housing lateral opening has a locking system for holding the pin magazine therein; and
the lateral opening having a projection for engaging an augmentation pin and wherein the locking system has a locking element for engaging the pin magazine to align the augmentation pin with the axial through-bore in the elongate housing for inserting the augmentation pin into the axial through bore of the augmentation screw, when the augmentation pin is located in the pin-retainer;
wherein the sonotrode is slidably and at least partially accommodated in the axial through-bores of the elongated housing and the augmentation screw when the elongated housing is connected to the augmentation screw, such that when the augmentation pin magazine is placed and locked in the lateral opening and at least one of the augmentation pins is aligned with the axial through-bore of the elongated housing, then the aligned augmentation pin is pushed by the sonotrode through at least a portion of the axial through-bore of the elongated housing, out of the housing and into the axial bore of the augmentation screw, and then fluidized within the axial bore of the augmentation screw due to ultrasound vibrations generated from the ultrasound transducer, then pressed out through the at least one lateral through bore of the augmentation screw, the at least one lateral through bore extending through a body portion of the augmentation screw and in fluid communication with the axial bore of the augmentation screw; and
wherein the augmentation pin magazine is configured to be further inserted and locked in the lateral through opening of the housing to align a second one of the retained polymeric augmentation pins with the axial through bore of the elongated housing to be prepared to be pushed by the sonotrode into the axial bore of the augmentation screw.

US Pat. No. 10,507,033

ULTRASONIC SURGICAL INSTRUMENT WITH REPLACEABLE CLAMP PAD

Ethicon LLC, Guaynabo, P...

1. An ultrasonic instrument comprising:(a) a shaft assembly, wherein the shaft assembly comprises an acoustic waveguide, wherein the waveguide is configured to acoustically couple with an ultrasonic transducer; and
(b) an end effector, wherein the end effector comprises:
(i) an ultrasonic blade in acoustic communication with the waveguide,
(ii) a clamp arm pivotally coupled with the shaft assembly, wherein the clamp arm further comprises a proximal portion and an elongated distal portion defining a recess, and
(iii) a clamp pad defining an interior sleeve comprising a T-shaped configuration, wherein the T-shaped configuration of the interior sleeve of the clamp pad is configured to house the elongated distal portion and the recess in a single predefined orientation in order to removably couple the clamp pad with the clamp arm while the clamp arm is pivotally coupled to the shaft assembly.

US Pat. No. 10,507,029

PATIENT-SPECIFIC ACETABULAR GUIDES AND ASSOCIATED INSTRUMENTS

Biomet Manufacturing, LLC...

2. An acetabular guide comprising:a patient-specific engagement surface designed to be complementary and mateable with a corresponding surface of the patient's pelvic anatomy as determined during a pre-operative plan of the patient by a three-dimensional reconstruction of the anatomy of the patient using two-dimensional medical images, the patient-specific engagement surface having a first portion mateable with a portion of an acetabulum of the patient;
a guiding element extending from the acetabular guide opposite to the first portion of engagement surface, the guiding element defining a bore designed to be oriented along an alignment axis for an acetabular implant when the acetabular guide is engaged to the acetabulum; and
first and second marker elements extending from a portion of the acetabular guide outside the acetabulum of the patient, the marker elements defining corresponding first and second bores for guiding first and second marker pins into a bone portion of the patient.

US Pat. No. 10,507,023

SELF-CENTERING SPIRAL FILTER

Cook Medical Technologies...

1. A filter for implantation in a body lumen, the filter comprising:a first loop having a first radius;
a second loop having a second radius, at least one of the first loop and the second loop being arcuately disposed about a longitudinal axis of the filter; and
a helical portion helically extending from the first loop to the second loop and comprising a plurality of turns, each turn having a radius of curvature increasing in the longitudinal direction from the first loop to the second loop;
wherein the filter is movable between a collapsed configuration and an expanded configuration, and
wherein at least one of the first loop, the second loop, and at least one turn of the helical portion are aligned at an angle of between 10 degrees and 50 degrees relative to the longitudinal axis when in the expanded configuration.

US Pat. No. 10,507,022

SURGICAL STAPLING APPARATUS

Covidien LP, Mansfield, ...

1. A surgical stapling apparatus comprising:a body portion;
a head portion disposed on a distal end of the body portion, the head portion supporting a plurality of staples;
an anvil assembly including an anvil, the anvil being movably supported in relation to the head portion between retracted and advanced positions, the anvil and the head portion defining a minimum tissue gap in the retracted position;
an approximation assembly extending through the body portion and the head portion, the approximation assembly having a distal end supporting the anvil assembly and being actuable to move the anvil assembly relative to the head portion, the approximation assembly including a screw extension secured to a drive screw, the screw extension and the drive screw being adapted to be secured together in at least first and second rotational orientations, wherein in the first rotational orientation the approximation assembly has a fixed first effective length and in the second rotational orientation the approximation assembly has a fixed second effective length, wherein the fixed first effective length is greater than the fixed second effective length, wherein in the first rotational orientation, the anvil and the head portion define a first minimum tissue gap therebetween and in the second rotational orientation, the anvil and the head portion define a second minimum tissue gap therebetween.

US Pat. No. 10,507,019

SURGICAL DEVICE FOR ADVANCING A SURGICAL KNOT

Abbott Laboratories, Abb...

1. A surgical device having a proximal end and a distal end, the surgical device comprising:an elongate shaft comprising a lumen extending proximally from a distal end of the elongate shaft;
a distal member disposed within the lumen at the distal end of the shaft and extending distally therefrom;
a suture retainer movable within the lumen and configured to move towards a proximal portion of the distal member, a distal end of the suture retainer being proximal an opening of the distal member in a suture-capture position; and
a cutting member slidably received within the lumen of the shaft and configured to cut a suture disposed within and extending from the opening of the distal member.

US Pat. No. 10,507,013

CLOSURE DEVICES, SYSTEMS, AND METHODS

Abbott Cardiovascular Sys...

1. A method of closing an opening in a tissue wall having a proximal surface and an opposing distal surface, the method comprising:deploying an anchor assembly, the anchor assembly comprising an anchor portion and an elongate portion, the anchor portion comprising one or more anchor sections configured to move from an initial contracted configuration to a deployed expanded configuration upon deployment of the anchor assembly, a proximal end of the anchor sections being mounted to an elongate member and a distal end of the anchor sections being mounted to a distal cap mounted to the elongate portion, the anchor portion comprises a first undulating section and a second undulating section, the first undulating section having a first end, a proximal loop, and a distal loop, the second undulating section having a second end, a proximal loop, and a distal loop, the first end of the first undulating section is connected to the second end of the second undulating section such that the first undulating section and the second undulating section form a stepped distal end of the anchor portion with the first undulating section and the second undulating section extending circumferentially around the elongate portion in a sinuous path;
positioning each of the anchor sections of the anchor portion against the distal surface of the tissue wall proximate the opening;
deploying a closure element to close the opening in the tissue wall, the anchor sections of the anchor portion remaining positioned against the distal surface of the tissue wall during deployment of the closure element; and
retracting the anchor sections of the anchor portion.

US Pat. No. 10,507,011

IMPACT BIOPSY DEVICE AND METHOD OF USE

Merit Medical Systems, In...

1. A tissue biopsy device, comprising:a handle;
a needle assembly operably coupled to the handle; and
an actuator assembly operably coupled to the handle and needle assembly, the actuator assembly comprising:
a biasing member;
a priming handle comprising a trigger surface;
a retention tube comprising a proximal catch;
a traveling member configured to be displaced when the actuator assembly is actuated, the traveling member comprising a traveling member catch;
an impact member coupled to the needle assembly, the impact member configured to displace at least a portion of the needle assembly when the traveling member impacts the impact member; and
a follower releasably coupled to the impact member,
wherein the needle assembly comprises an outer tubular member and a cannula, and wherein the outer tubular member is fixedly coupled to the impact member and the cannula is releasably coupled to the impact member,
wherein the traveling member catch is configured to engage with the proximal catch of the retention tube when the actuator assembly is in a primed configuration, and
wherein the trigger surface of the priming handle is configured to displace the traveling member catch from the proximal catch when the actuator assembly is actuated.

US Pat. No. 10,507,006

SYSTEM AND METHOD FOR TRACKING AN INVASIVE DEVICE USING ULTRASOUND POSITION SIGNALS

GENERAL ELECTRIC COMPANY,...

1. A system for tracking an invasive device, the system comprising:an ultrasound probe configured to be inserted into a patient's body, the ultrasound probe comprising an array including a plurality of transducer elements, wherein the array is configured both for acquiring ultrasound image data and for tracking a position of the ultrasound probe;
a display device;
a localization system comprising:
a substrate configured to be externally attached to the patient;
an ultrasound transducer module comprising at least one transducer element attached to the substrate, where the ultrasound transducer module is configured to communicate ultrasound signals with the array; and
a connector device electrically connected to the ultrasound transducer module; and
a processing unit in electronic communication with the ultrasound transducer module, the display device and the ultrasound probe, wherein the processor is configured to:
determine a position of the ultrasound probe based on the ultrasound signals communicated between the array and the at least one transducer element attached to the substrate;
generate an ultrasound image based on the ultrasound image data acquired by the array;
display the ultrasound image on the display device; and
display the position of the ultrasound probe on the display device based on the ultrasound signals communicated between the array and the at least one transducer element attached to the substrate.

US Pat. No. 10,507,003

QUANTIFICATION PHANTOM FOR USE WITH MULTIPLE IMAGING MODALITIES

BAYER HEALTHCARE LLC, Wh...

1. An in-scan phantom for use during an imaging procedure of a patient, the in-scan phantom comprising:at least one measured insert for measuring at least one property of the patient during the imaging procedure;
wherein the measured insert comprises a radioactive material.

US Pat. No. 10,507,001

X-RAY APPARATUS AND X-RAY SYSTEM

Samsung Electronics Co., ...

1. An X-ray apparatus comprising:an X-ray radiator configured to radiate X-rays;
a detection device comprising a grid configured to selectively transmit the X-rays radiated from the X-ray radiator and a detector configured to detect the X-rays transmitted through the grid;
a controller configured to obtain:
arrangement information that indicates an arrangement status of the X-ray radiator and the detection device, the arrangement status comprising an angular relationship and a distance relationship between the X-ray radiator and the detection device, and
quality information that indicates a quality of an X-ray image, which corresponds to the arrangement status, wherein the X-ray image is obtained based on the detected X-rays selectively transmitted through the grid; and
an output device configured to output the arrangement information and the quality information.

US Pat. No. 10,507,000

METHOD FOR SIMULTANEOUS IMAGING OF FUNCTIONAL AND MORPHOLOGICAL X-RAY IMAGE DATA OF A BREAST, DIAGNOSTIC STATION, COMPUTER PROGRAM PRODUCT AND COMPUTER-READABLE MEDIUM

Siemens Healthcare GmbH, ...

15. A diagnostic station, comprising:an acquisition interface for acquiring a functional X-ray image data set including two-dimensional mammogram image data, from the breast of a patient, and for acquiring a morphological X-ray image data set including three-dimensional image data from the breast of the patient in the same breast position and with the same breast compression;
an input interface for determining a region of interest in one of the two acquired X-ray image data sets;
a position-determining unit for determining a three-dimensional position of the region of interest in the other of the two acquired X-ray image data sets by:
calculating a synthetic mammogram on a basis of the three-dimensional tomosynthesis image data;
generating a low-energy image on a basis of the two-dimensional dual-energy mammogram image data;
comparing structures encompassed by the region of interest with structures of the synthetic mammogram;
localizing and marking structures encompassed by the region of interest in the two-dimensional dual-energy mammogram image data;
transferring the region of interest to the synthetic mammogram; and
back-projecting the synthetic mammogram provided with the region of interest onto a three-dimensional tomosynthesis graphical representation; and
an image display unit for simultaneous graphical representation of the functional X-ray image data and the morphological X-ray image data each with the region of interest as a marked region.

US Pat. No. 10,506,993

DUAL ENERGY DIFFERENTIAL PHASE CONTRAST IMAGING

KONINKLIJKE PHILIPS N.V.,...

1. An X-ray imaging apparatus, comprising:an X-ray source configured to emit X-ray radiation;
an X-ray detector configured to detect the X-ray radiation;
an interferometer arranged between said X-ray source and said detector, said interferometer comprising at least one interferometric grating, wherein said interferometric grating is tiltable around a first axis perpendicular to an optical axis of said X-ray imaging apparatus, such that the interferometric grating is capable of being oriented at different tilt angles relative to said first axis;
at least one source grating arranged between the interferometric grating and the X-ray source, the source grating being configured to convert the X-ray radiation into X-ray radiation with increased coherence;
a grating adapter mechanism configured to adapt for an effective grating pitch with respect to the source grating and/or the interferometer, wherein the grating adapter mechanism is configured to i) exchange the source grating for a new source grating having a different pitch, or ii) combine said source grating with another source grating having a different pitch in order to compensate for a change in effective path length through a space between said source grating and said interferometer.

US Pat. No. 10,506,988

METHODS AND SYSTEMS FOR FORECASTING SEIZURES

SEER MEDICAL PTY LTD, (A...

1. A method of estimating the probability of a seizure in a subject, the method comprising:receiving historical data associated with epileptic events experienced by the subject over a first time period, the historical data comprising physiological data associated with each epileptic event and a time at which each epileptic event occurred;
generating a temporal probability model of future epileptic events based on the time of each of the epileptic events, the temporal probability model representing a probability of a future seizure occurrence in each of a plurality of future time windows;
generating a probabilistic model based on the physiological data associated with each epileptic event;
combining the probabilistic model and the temporal probability model to generate a weighted probabilistic model representing a time-weighted probability of future seizure activity in each of the plurality of future time windows; and
outputting an estimate of seizure probability in the subject for one or more of the plurality of future time windows using the weighted probabilistic model.

US Pat. No. 10,506,985

METHODS AND SYSTEMS FOR DIAGNOSING OR MONITORING PROGRESS OF A PATHOLOGY USING LASER INDUCED BREAKDOWN SPECTROSCOPY AND BIOLOGICAL FLUIDS

The University of Massach...

1. A method for diagnosing or monitoring progress of a pathology using laser induced breakdown spectroscopy (LIBS) and biological fluids, the method comprising:depositing a sample of a predetermined biological fluid on a predetermined substrate;
focusing light from a laser source on the sample deposited on the predetermined substrate; energy and pulse length of the laser source being configured to cause ablation of the sample and the predetermined substrate and formation of a plasma;
collecting optical emission from the plasma using an optical detection system;
providing collected optical emission to a spectroscopic acquisition component; the spectroscopic acquisition component providing information on spectral data;
providing the spectral data from the collected optical emission to a processing component; the processing component comprising one or more processors;
using a machine learning algorithm and the one or more processors to diagnose the pathology or monitor progress of the pathology; wherein the machine learning algorithm is trained on a training set comprising spectral data for LIBS collected optical emission from samples of the predetermined biological fluid on the predetermined substrate which have known pathology or known progress of the pathology;
wherein the predetermined substrate has ionization energy lower than ionization energies of C or H and is also configured to provide higher signal-to-noise ratio than other candidate substrates with ionization energy lower than ionization energies of C or H and also configured to provide higher classification accuracy, obtained using the machine learning algorithm, of greater than a predetermined value.

US Pat. No. 10,506,984

BODY LANDMARK DETECTION BASED ON DEPTH IMAGES

Siemens Healthcare GmbH, ...

1. A system comprising:a memory configured to store a plurality of sets of body surface data and, for each set of body surface data, data of a plurality of landmark traces, where each of the plurality of landmark traces is associated with one or more body landmark locations; and
a processor configured to execute processor-executable program code to:
train, using the plurality of sets of body surface data and data of a first landmark trace of each of the plurality of sets of body surface data, a first reinforcement learning network to identify a first one or more body landmark locations associated with the first landmark trace, where a result is a trained first reinforcement learning network; and
train, using the plurality of sets of body surface data and data of a second landmark trace of each of the plurality of sets of body surface data, a second reinforcement learning network to identify a second one or more body landmark locations associated with the second landmark trace, where a result is a trained second reinforcement learning network.

US Pat. No. 10,506,983

APPLICATION OF THE EXTREMA DISTORTION METHOD TO OPTIMIZE CONTROL SIGNALS

University of Massachuset...

1. A system for controlling a signaling pathway in a subject of interest, comprising:a sensor configured to observe a signal in the subject of interest, and configured to provide an electrical representation of said signal for further manipulation;
a module configured to accept as input said electrical representation of said signal for further manipulation;
a module configured to apply the Extrema Distortion Algorithm to said electrical representation of said signal, and configured to generate a synthetic control signal;
a module configured to provide said synthetic control signal as an output; and
a signal application module configured to receive said synthetic control signal and configured to apply said synthetic control signal to the subject of interest, wherein
said module configured to apply the Extrema Distortion Algorithm is a general purpose programmable computer which when operating under control of instructions recorded on a non-volatile medium is configured to perform the steps of said Extrema Distortion Algorithm, and
said Extrema Distortion Algorithm includes instructions recorded on said non-volatile medium that are configured to direct said general purpose computer to: (a) Select a randomly generated starting seed that successfully causes a state transition, (b) Find the extrema of the starting seed and measure the time interval between them, (c) Multiply each of the time intervals by a randomly generated number (e.g. with a Gaussian distribution), (d) Rescale the time of the synthetic stimulus to match the duration of the original stimulus, (e) Add to each peak a randomly generated number (e.g. with a Gaussian distribution), (f) Linearly transform all the data points between the extrema with the new extrema endpoints, (g) Test the distorted stimulus in the system, checking to see if it achieves pre-specified constraints, (h) Calculate the performance metric (e.g. L2-norm) of each of the neighboring stimuli, (i) Repeat steps (c)-(h) N times to produce N neighboring solutions based on the starting seed, (j) Choose the stimulus from among the neighboring solutions and the starting seed with the best performance, (k) Repeat steps (b)-(j) for a predetermined number of times M each iteration using the best stimuli found from the previous iteration as the new starting seed in step (b), and (l) After M iterations, output the stimulus with the best performance metric as the optimal stimulus.

US Pat. No. 10,506,981

VITAL SIGN DETECTION SYSTEM WITH RANDOM BODY MOVEMENT CANCELLATION

NATIONAL SUN YAT-SEN UNIV...

1. A vital sign detection system comprising:a radar device configured to output an output signal;
a nonreciprocal network coupled to the radar device;
a first antenna coupled to the nonreciprocal network; and
a second antenna coupled to the nonreciprocal network;
wherein the output signal from the radar device is configured to be delivered to the first antenna via the nonreciprocal network and then transmitted to a first side of a biological subject via the first antenna, and a first reflection signal from the first side of the biological subject is received by the first antenna and configured to be delivered to the second antenna via the nonreciprocal network and then transmitted to a second side of the biological subject via the second antenna, and a second reflection signal from the second side of the biological subject is received by the second antenna and configured to be delivered to the radar device via the nonreciprocal network.

US Pat. No. 10,506,978

BAND TIGHTNESS SENSOR OF A WEARABLE DEVICE

Apple Inc., Cupertino, C...

1. A wearable device, comprising:a housing including a processing unit and a health sensor;
a band operable to couple the housing to a body part of a user; and
a tightness sensor, coupled to the band and communicably coupled to the processing unit, comprising a strain gauge that produces a signal indicating a tightness of the band;
wherein the processing unit is configured to:
determine the tightness of the band using the signal; and
if the tightness of the band is outside a range of tightness values, provide output directing the user to adjust the band to improve operation of the health sensor; wherein:
the strain gauge is embedded in the band.

US Pat. No. 10,506,974

HEADSETS AND ELECTRODES FOR GATHERING ELECTROENCEPHALOGRAPHIC DATA

THE NIELSEN COMPANY (US),...

1. An electrode unit comprising:a housing having a cavity defined by an opening in a side of the housing; and
an electrode constructed of a conductive material, the electrode including:
a ring disposed in the opening; and
an arm coupled to the ring, the arm having:
a first end coupled to the ring;
a second end opposite the first end;
a bend between the first end and the second end;
a first portion between the first end and the bend, the first portion extending outward from the opening away from the housing; and
a second portion between the bend and the second end, the second portion extending from the bend toward the housing and into the cavity.

US Pat. No. 10,506,962

SYSTEM AND METHOD FOR INTRAOPERATIVE CHARACTERIZATION OF BRAIN FUNCTION USING INPUT FROM A TOUCH PANEL DEVICE

SUNNYBROOK RESEARCH INSTI...

1. A system for performing an intraoperative assessment of brain function, the system comprising:an intervention device configured to apply an intervention to a patient's brain;
a tracking device configured to track a location of the intervention device within an intraoperative reference frame;
a touch panel device configured to receive input from the patient;
a display device; and
a computing device operatively connected to said tracking device, said touch panel device, and said display device, the computing device comprising a processor coupled to a memory, wherein the processor, in response to executing instructions stored in the memory, is configured to:
obtain, via the touch panel device, intraoperative input from the patient in response to a task;
determine a measure associated with the intraoperative input when the intervention is applied to a selected region of the patient's brain; and
display, on the display device, visual output associating the measure with the selected region;
wherein said intervention device is configured to apply a stimulation to the brain; and
wherein said processor is further configured to:
detect an event associated with the task; and
control the timing of the application of the stimulation in relation to the event.

US Pat. No. 10,506,958

MULTI-STREAM DATA COLLECTION SYSTEM FOR NONINVASIVE MEASUREMENT OF BLOOD CONSTITUENTS

Masimo Corporation, Irvi...

1. A physiological measurement system comprising:a physiological sensor device comprising:
a plurality of emitters configured to emit light into tissue of a user;
at least four detectors, wherein each of the at least four detectors has a corresponding window that allows light to pass through to the detector;
a wall that surrounds at least the at least four detectors; and
a cover that operably connects to the wall and that is configured to be located between tissue of the user and the at least four detectors when the physiological sensor device is worn by the user, wherein:
the cover comprises a single protruding convex surface, and
at least a portion of the cover is sufficiently rigid to cause tissue of the user to conform to at least a portion of a shape of the single protruding convex surface when the physiological sensor device is worn by the user; and
a handheld computing device in wireless communication with the physiological sensor device, wherein the handheld computing device comprises:
one or more processors configured to wirelessly receive one or more signals from the physiological sensor device, the one or more signals responsive to at least a physiological parameter of the user;
a touch-screen display configured to provide a user interface,
wherein:
the user interface is configured to display indicia responsive to measurements of the physiological parameter, and
an orientation of the user interface is configurable responsive to a user input; and
a storage device configured to at least temporarily store at least the measurements of the physiological parameter.

US Pat. No. 10,506,956

MULTI-STREAM DATA COLLECTION SYSTEM FOR NONINVASIVE MEASUREMENT OF BLOOD CONSTITUENTS

Masimo Corporation, Irvi...

1. A noninvasive optical physiological sensor comprising:a plurality of emitters configured to emit light into tissue of a user;
a plurality of detectors configured to detect light that has been attenuated by tissue of the user, wherein the plurality of detectors comprise at least four detectors, and wherein the plurality of detectors are arranged on a substrate;
a wall configured to circumscribe at least the plurality of detectors; and
a cover configured to be located between tissue of the user and the plurality of detectors when the noninvasive optical physiological sensor is worn by the user, wherein the cover comprises a single protruding convex surface operable to conform tissue of the user to at least a portion of the single protruding convex surface when the noninvasive optical physiological sensor is worn by the user, and wherein the wall operably connects to the substrate and the cover.

US Pat. No. 10,506,955

METHOD AND APPARATUS FOR NON-INVASIVE DETERMINATION OF A MEASURED VARIABLE OF AN ANALYTE IN A BIOLOGICAL BODY

1. A method of non-invasive determination of a measured variable of an organic analyte in a biological body, the method comprising:locally irradiating the body, in an automated manner, sufficient for causing at least some of the light to penetrate into the body and to be absorbed by the organic analyte, with light having a wavelength range between 6 ?m and 16 ?m matched to an absorption signature of the organic analyte, whereupon the body heats up at least locally as a result of an absorption by the organic analyte;
detecting a consequently occurring change in a speckle pattern of coherent light scattered at the body, and deducing from the change in the speckle pattern a value of the measured variable of the organic analyte.

US Pat. No. 10,506,954

MOBILE AUTOMATED HEALTH SENSING SYSTEM, METHOD AND DEVICE

1. A personal health monitoring system consisting of:A personal communication smartphone device incorporating one or more central processing units configured to interpret glucose in saliva, one or more cameras, internet connection means and near field wireless communication means, cloud based data storage and computing resources programmed to detect glucose in saliva color change of detection chemicals of a sample detector health sample interpretation software programmed to detect glucose in saliva color change of the detection chemicals of an receptacle, health sample collection means and health sample detector wherein said health sample detector additionally comprises one or more health sample detection chemicals which in the presence of peroxidase, 10-acetyl-3,7-dihydroxyphenoxazine reacts with H2O2 in a 1:1 stoichiometry to produce a red color change in the presence of glucose in a saliva sample.

US Pat. No. 10,506,951

JOINT PLAY QUANTIFICATION AND ANALYSIS

RoboDiagnostics LLC, Atl...

1. A method of evaluating a joint, the method comprising:obtaining, by a processor, rotational data and translational data captured via a robotic testing apparatus for the joint, the rotational and translational data being indicative of rotational and translational movement of the joint, respectively, during rotational and translational joint testing, the rotational and translational joint testing being implemented by the robotic testing apparatus applied to the joint, the robotic testing apparatus comprising a plurality of motors for the rotational and translational joint testing, the rotational data and the translational data being indicative of one or more rotational ranges of motion and one or more translational ranges of motion, respectively, for the rotational and translational joint testing;
computing, by the processor, a quantity indicative of a joint play volume of the joint, the quantity being computed via a function, the function comprising a multiplication of the one or more rotational ranges of motion and the one or more translational ranges of motion for the rotational data and the translational data;
determining, by the processor, whether the joint has an abnormality by determining whether the computed quantity exceeds a joint play volume threshold;
if the computed quantity exceeds the joint play volume threshold, comparing, by the processor, the rotational data and the translational data with preset rotational data and preset translational data for the rotational and translation joint testing, respectively, to identify the abnormality of the joint; and
wherein determining that the joint has an abnormality based on the computed quantity is a prerequisite to identifying the abnormality, such that comparing the rotational data and the translational data with the preset rotational data and the preset translational data is implemented after determining that the computed quantity exceeds the joint play volume threshold.

US Pat. No. 10,506,948

LOCALIZATION FOR ELECTROCARDIOGRAPHIC MAPPING

CARDIOINSIGHT TECHNOLOGIE...

1. A system to localize an object in a patient's body, the system comprising:at least one electrode fixed to the object in the patient's body;
a pulse generator configured to generate a localization signal comprising a subthreshold electrical signal and provide the localization signal to the at least one electrode, the subthreshold electrical signal having energy insufficient to stimulate electrical conduction in tissue of the patient's body;
a sensor array configured to detect an electrical field produced in response to the localization signal and provide respective sensor signals; and
a processor configured to:
retrieve geometry data stored in memory, the geometry data representing a geometric relationship between patient anatomy and the sensor array;
reconstruct electrical signals based on the respective sensor signals and the geometry data; and
determine an absolute location where the localization signal was applied based on comparing amplitude and frequency characteristics of each of the reconstructed electrical signals with respect to the localization signal.

US Pat. No. 10,506,942

IN-VIVO SIGNAL SOURCE DETECTION METHOD AND IN-VIVO SIGNAL SOURCE DETECTION DEVICE

TORAY ENGINEERING CO., LT...

1. An in-vivo signal source detection method for detecting a position of a signal source in a living body by a voltage generated at an electrode arranged on a surface of the living body, whereinat least three electrodes are arranged on a circumference of the surface of the living body to surround multiple muscle fibers, and a first external resistor and a second external resistor are alternately switchably connected in parallel between each electrode and a ground potential or between ones of the electrodes,
a first voltage Vi (i=1, 2, 3) generated when the first external resistor is connected to between each electrode and the ground potential or between ones of the electrodes and a second voltage V?i (i=1, 2, 3) generated when the second external resistor is connected to between each electrode and the ground potential or between ones of the electrodes are measured, and
a ratio Vi/V?i (i=1, 2, 3) is calculated from the first voltage Vi and the second voltage V?i, and the position of the signal source in the living body is detected based on three ratios Vi/V?i (i=1, 2, 3).

US Pat. No. 10,506,940

STIMULATION PROGAMMING AID USING A SENSORY PROJECTION

Boston Scientific Neuromo...

1. A method implemented by a system having processing circuitry, the method comprising:receiving a user-perceivable input comprising at least one of an audio signal or a haptic signal;
determining an electrical waveform, using the processing circuitry, based on the user-perceivable input; and
delivering the electrical waveform to at least one electrode, the at least one electrode configured to deliver neurostimulation to the patient.

US Pat. No. 10,506,938

CATHETER WITH STACKED SPINE ELECTRODE ASSEMBLY

BIOSENSE WEBSTER (ISRAEL)...

1. A catheter comprising:an elongated catheter body; and
an electrode array distal of the catheter body, the array comprising
a first spine support including a first base and a first plurality of spines having first distal spine portions and first proximal spine portions extending from the first base, and
a second spine support including a second base and a second plurality of spines having second distal spine portions and second proximal spine portions extending from the second base and laterally offset from the first proximal spine portions,
a first electrode carried on the first plurality of spines, and
a second electrode carried on the second plurality of spines.

US Pat. No. 10,506,930

MICROWAVE THERMOMETER FOR INTERNAL BODY TEMPERATURE RETRIEVAL

The University of Colorad...

1. A microwave thermometry system comprising:a wearable probe assembly that operates, when placed on a skin site of an individual, to receive near-field radiation at the skin site;
a radiometer coupled with the probe assembly to detect a total power of the received near-field radiation; and
a signal processing system coupled with the radiometer to convert the detected total power to an internal tissue temperature measurement as a function of applying the detected total power to a tissue stack model,
the tissue stack model characterizing the skin site according to a set of weighting functions, each weighting function corresponding at least to electromagnetic characteristics of an associated tissue layer of the tissue stack model.

US Pat. No. 10,506,929

ANESTHETIC SYRINGE WITH A NERVE DETECTOR

Imam Abdulrahman Bin Fais...

1. An anesthetic syringe comprising:a hollow syringe barrel with a needle mount extending outwards from a first end of the hollow syringe barrel;
a plunger extending from a second end of the hollow syringe barrel and slidably moveable within the hollow syringe barrel; the plunger having a piston-engaging tip extending into the hollow syringe barrel;
a first illuminated indicator directly attached to an exterior part of the hollow syringe barrel or mounted to an arm directly attached to the exterior part of the hollow syringe barrel;
a transmitter configured to emit an emitted radiative energy onto a nerve;
a nerve detector directly attached to the first illuminated indicator or directly attached to a second exterior part of the hollow syringe barrel, the nerve detector configured to receive an incoming radiative energy from the nerve;
a spectrometer attached to and in direct contact with an interior side of the hollow syringe barrel,
wherein the spectrometer is configured to detect blood in an aspirate;
a second illuminated indicator on an exterior side of the hollow syringe barrel and electrically connected to the spectrometer to indicate if blood has been detected during aspiration; and
wherein the first illuminated indicator is electrically connected to the nerve detector and is configured to receive a signal from the nerve detector and indicate at least one direction to move the anesthetic syringe to deliver an anesthetic injection proximal to the nerve,
wherein the incoming radiative energy is not visible light and is not an electric field, and
wherein the first illuminated indicator comprises:
a first display panel mounted to a first arm, the first arm directly attached to the exterior part of the hollow syringe barrel, and
a second display panel mounted to a second arm, the second arm directly attached to the exterior part of the hollow syringe barrel.

US Pat. No. 10,506,928

SYSTEMS, DEVICES, AND METHODS FOR IDENTIFYING PORTIONS OF A WOUND FILLER LEFT AT A TISSUE SITE

KCI Licensing, Inc., San...

1. A method for treating a wound, the method comprising:positioning a wound filler treated with a liquid coating agent containing fluorescent markers proximate the wound;
removing the wound filler from the wound after a time period;
scanning the wound using a fluorescence scanner to determine whether a residual portion of the wound filler remains at the wound by detecting the fluorescent markers on to the residual portion with the fluorescence scanner; and
responsive to detecting the residual portion of the wound filler remaining at the wound, removing the residual portion of the wound filler from the wound.

US Pat. No. 10,506,925

REFLECTOMETRY INSTRUMENT AND METHOD FOR MEASURING MACULAR PIGMENT

ZeaVision, LLC, Chesterf...

1. A reflectometry instrument to measure macular pigment of a macula of a human eye, comprising:a housing including an illumination system, a detection system, and a beam dump, the illumination system configured to generate an illumination beam and direct the illumination beam to the macula, a detection beam being generated as a portion of the illumination beam reflected by the macula, the detection system configured to receive and measure the detection beam to determine an amount of the macular pigment in the macula, and the beam dump being in optical alignment with an optical input of the detection system for absorbing stray light within the reflectometry instrument; and
an eyepiece connected to the housing and being configured to interface with the human eye to prevent ambient light from entering the housing,
wherein the beam dump and the eyepiece allow the reflectometry instrument to measure the macular pigment of the macula in a lit environment.

US Pat. No. 10,506,923

OPTICAL IMAGING AND MEASUREMENT SYSTEMS AND METHODS FOR CATARACT SURGERY AND TREATMENT PLANNING

AMO WaveFront Sciences, L...

1. An eye imaging and measurement system for planning a cataract treatment in a patient's eye, the system comprising:a corneal topography subsystem;
a wavefront aberrometer subsystem;
an eye structure imaging subsystem; and
a memory,
wherein the corneal topography subsystem, wavefront aberrometer subsystem, and eye structure imaging subsystem have a shared optical axis, and each subsystem is operatively coupled to the other subsystems via a controller,
wherein each of the corneal topography subsystem, the wavefront aberrometer subsystem and the eye structure imaging subsystem stores data in the memory, wherein the data includes anterior conical surface information, posterior corneal surface information, anterior lens surface information, posterior lens surface information, lens tilt information and lens position information,
wherein the eye imaging and measurement system, including the corneal topography subsystem, the wavefront aberrometer subsystem and the eye structure imaging subsystem, measures ocular biometry information and store the ocular biometry information in the memory, wherein the ocular biometry information comprises a central corneal thickness (CCT), anterior chamber depth (ACD), pupil diameter (PD), white to white distance (WTW), lens thickness (LT), axial length (AXL) and retinal layer thickness, and
wherein the memory is further operable to store Intraocular Lens (“IOL”) Data, the IOL data including a plurality of dioptic power, anterior and posterior radius, IOL thickness, refractive index and dispersion, asphericity, toricity, echelette features, haptic angulation, and lens filter.

US Pat. No. 10,506,919

OPERATION SWITCHING MECHANISM AND ENDOSCOPE

OLYMPUS CORPORATION, Tok...

1. An operation switching mechanism comprising:an elongated member configured to transmit a force for operating an operating section;
a movement member to which the elongated member is connected, the movement member moving between a first movement position and a second movement position together with the elongated member;
a first biasing member configured to bias the movement member toward the first movement position;
a second biasing member configured to bias the movement member toward the second movement position on an opposite side to a side that the first biasing member biases the movement member;
a switching member including:
a first switching member configured to switch between suppression of biasing by the first biasing member and release of the suppression of the biasing by the first biasing member, and
a second switching member configured to switch between suppression of biasing by the second biasing member and release of the suppression of the biasing by the second biasing member,
wherein the switching member is configured to switch to one of the suppression of the biasing by the first biasing member by the first switching member, the suppression of the biasing by the second biasing member by the second switching member, and suppression of biasing by both of the first biasing member and the second biasing member by the first switching member and the second switching member, respectively; and
an operation member configured to operate the switching member and move the movement member to the first movement position or to the second movement position, wherein
the first biasing member includes a first biasing spring and a first pressing member, the first pressing member being provided to the first biasing spring, configured to press the movement member, and including a first deformation portion,
the second biasing member includes a second biasing spring and a second pressing member, the second pressing member being provided to the second biasing spring, configured to press the movement member, and including a second deformation portion,
the first switching member includes a first protrusion and a first movement member, wherein the first movement member is configured to move in a direction crossing a longitudinal direction of the elongated member between a first position at which the first protrusion comes into contact with the first pressing member to suppress the biasing by the first biasing spring and a second position at which the first deformation portion is deformed to release the contact of the first protrusion with the first pressing member to thereby release the suppression of the biasing by the first biasing member, and
the second switching member includes a second protrusion and a second movement member, wherein the second movement member is configured to move in the direction crossing the longitudinal direction of the elongated member between a third position at which the second protrusion comes into contact with the second pressing member to suppress the biasing by the second biasing spring and a fourth position at which the second deformation portion is deformed to release the contact of the second protrusion with the second pressing member to thereby release the suppression of the biasing by the second biasing member.

US Pat. No. 10,506,913

APPARATUS OPERATION DEVICE, APPARATUS OPERATION METHOD, AND ELECTRONIC APPARATUS SYSTEM

FUJIFILM Corporation, To...

1. An apparatus operation device comprising:a display that displays a virtual object in a pseudo manner; and
a processor configured to:
detect a line of sight of a user,
detect one or more gestures of the user performed on the virtual object that is displayed in a pseudo manner,
determine, based on the line of sight that has been detected and the one or more gestures that have been detected, a target apparatus to be operated and operation details for the target apparatus,
control the target apparatus and causes the target apparatus to execute the operation details that have been determined,
detect a first point of gaze from an image of the user's eye, and detect a second point of gaze according to a movement of the line of sight,
determine, based on the movement of the line of sight between the detected first point of gaze and second point of gaze, the target apparatus and the operation details for the target apparatus, and
determine an operation target region in which the first point of gaze and second point of gaze are on a border.

US Pat. No. 10,506,911

DISHWASHER

SAMSUNG ELECTRONICS CO., ...

1. A dishwasher comprising:a body having a tub;
a nozzle;
a guide rail extending in a first direction on a bottom surface of the tub;
a reflector having a reflecting surface facing the nozzle and extending in a direction perpendicular to the first direction, the reflector to deflect a water sprayed from the nozzle approximately toward dish; and
a driver configured to move the reflector along the guide rail in the first direction;
wherein, in response to an external force acting on the reflector while the reflector moves along the guide rail in the first direction, the reflector moves along the guide rail in a second direction.

US Pat. No. 10,506,910

DISHWASHER AND METHOD OF MANUFACTURING THE SAME

LG ELECTRONICS INC., Seo...

1. A dishwasher comprising:a cabinet;
a tub defining a washing space therein;
a sump disposed under and coupled to the tub;
a pump for transferring washing water stored in the sump;
a heating unit disposed under the pump so as to heat washing water; and
a base defining a lower part of the cabinet,
wherein the sump includes a sump mount, the sump mount being temporarily mounted on the base after the pump and the heater are coupled to the sump, and the base includes a first position guide, the sump mount being mounted on the first position guide so as to guide the sump to a coupling position with respect to the base,
wherein the sump mount is coupled into the first position guide,
wherein the first position guide and the sump mount are configured to be asymmetric in a specific direction,
wherein the sump mount has a ‘D’ shape section having a linear cross section and a curved cross section such that the sump mount is coupled to the first position guide in a consistent direction,
wherein the pump includes a coupler for coupling the pump to the sump, and the base includes a second position guide on which the coupler is mounted,
wherein the coupler includes two couplers, and the second position guide includes two second position guides separated from each other, and
wherein the sump is supported at three points by the first position guide and the second position guides of the base after the pump and the heater are coupled to the sump.

US Pat. No. 10,506,906

TILE AND GROUT CLEANING PADS AND TOOLS

1. A cleaning system for multi-level surfaces, comprising:a handle, comprising:
a shaft comprising a first end and a second end,
a handle grip attached at said first end of said shaft,
a first joint coupling attached at said second end of said shaft, and
a second joint coupling rotatably attached to said first joint coupling by a pin;
a substantially rectangular cleaning head, comprising:
a center,
a longitudinal axis,
a transverse axis,
a top face comprising 2 handle mounts oriented along said longitudinal axis of said cleaning head around said center and 4 grippers,
a bottom face, and
2 mounting holes oriented along said transverse axis around said center and extending from said top face to said bottom face;
a brush, comprising:
a substantially rectangular body,
a first face comprising bristles, and
a second face comprising two fasteners configured to pass through said mounting holes of said cleaning head; and
a cleaning pad, comprising:
a backing,
a cleaning surface,
four attachment points configured to attach to said grippers of said cleaning head, and
two holes configured to allow said fasteners of said brush to pass through said cleaning pad,
wherein said cleaning pad covers is wrapped around said cleaning head to cover said bottom face and said grippers removably attach said cleaning pad to said cleaning head by affixing to said attachment points, said cleaning pad providing a first cleaning surface for cleaning a first leveled surface,
wherein said brush extends along said transverse axis of said cleaning head underneath said cleaning pad, said brush being removably attached to said cleaning pad and said cleaning head by said fasteners passing through said cleaning head and said cleaning pad to secure said brush in place, said brush providing a second cleaning surface at a lower depth than said first cleaning surface for cleaning a second leveled surface simultaneously with the cleaning of said first leveled surface, and
wherein said second joint coupling is rotatably attached to said handle mounts of said cleaning head.

US Pat. No. 10,506,899

MOVABLE BATHTUB ASSEMBLY

1. A movable bathtub assembly comprising a bathtub and a mechanism to displace it comprising two pair of arms, each pair of arms on the opposite side of the bathtub (1), whereas each pair of arms (2,3) is connected at a first end, via a frame (6,50), to a base (30) and/or to a wall (36) by a first pair of articulated joints (9, 11) and is connected at a second end, via a bed (4), to the bathtub (1) by a second pair of articulated joints (15, 16),wherein all arms, joints and mechanism mounting structures are arranged below an upper edge (29) of the bathtub (1) supported by bathtub legs (7) on the base (30) and situated in the bathing position, about horizontally having a center, completely inside a space defined by the upper edge (29) of the bathtub (1), the base (30) and walls (36) adjacent to the bathtub (1), in such way, that the bathtub is displaced following the rotation of the two pair of arms (2, 3) from a bathing position to a vertical position, where a concave side of the bathtub faces towards the place of the center of the bathtub when in the bathing position,
whereas the arms and the bathtub (1) form a four-bar linkage with oscillating links defining the bathtub (1) trajectory,
wherein the movement of the arms (2, 3) is synchronised on both sides of the bathtub (1) by a stiff connection of one arm (2, 3) from the first pair to the corresponding arm (2, 3) from the second pair by a coupling element (10).

US Pat. No. 10,506,888

FRAME WITH INTERCHANGEABLE PANELS

Bay Island, LLC, Minneto...

1. A frame comprising:a body including at least one interior surface that defines a cavity, wherein a first channel is disposed on a first portion of the interior surface and a second channel is disposed on a second portion of the interior surface, the first channel is configured to receive a first end of a rod and the second channel is configured to receive a second end of the rod such that the rod extends between and slidably engages the first and second channels, and
wherein the cavity is configured to receive at least one panel, and the body further includes a front border that defines a window, wherein the front border comprises an interior lip that protrudes inwardly toward the center of the frame from the at least one interior surface of the body of the frame, and
wherein the body further comprises a front side and a back side, wherein the at least one interior surface extends from the front side to the back side of the body, and wherein each of the first channel and second channel includes a front end and a back end, wherein the front end of each of the first and second channels is more proximate to the front side of the body than the back end of each of the first and second channels.

US Pat. No. 10,506,887

ITEM ALIGNMENT TOOL

Walmart Apollo, LLC, Ben...

1. An item alignment tool for aligning items on a shelf, comprising:an elongated planar body defining a proximal end, a distal end, a bottom straight edge, a top edge, and first and second opposing sides extending between the bottom straight edge and the top edge, the proximal and distal ends of the elongated planar body defining opposing endpoints of the item alignment tool;
a handle coupled to the proximal end of the elongated planar body; and
a wrap permanently secured to the elongated planar body, the wrap positioned over and covering at least a portion of the bottom straight edge of the elongated planar body to provide a protective layer for sliding along a surface of a shelf to facilitate alignment of items on the shelf,
wherein:
the wrap extends over at least a portion of the first and second opposing sides of the elongated planar body;
the handle comprises a first handle half and a second handle half coupled on opposing sides of the elongated planar body; or
the wrap is permanently secured to the elongated planar body with adhesive to prevent removal of the wrap from the elongated planar body.

US Pat. No. 10,506,875

PANELS COMPRISING A MECHANICAL LOCKING DEVICE AND AN ASSEMBLED PRODUCT COMPRISING THE PANELS

VALINGE INNOVATION AB, V...

1. A set of panels comprising a first panel with a first main plane and a second panel with a second main plane, wherein the first panel and the second panel are provided with a mechanical locking device for locking a first edge of the first panel to a second edge of the second panel at a junction plane, wherein the first main plane is essentially perpendicular to the second main plane and the junction plane is extending between the first main plane and the second main plane,wherein the first edge comprises an edge tongue that extends from the junction plane,
wherein the second edge comprises an edge groove at the junction plane, wherein the edge tongue is configured to cooperate with the edge groove for locking together the first edge and the second edge in a first direction which is parallel to the junction plane,
wherein the edge tongue comprises a tongue groove,
wherein the edge groove comprises a flexible tongue arranged in an insertion groove, said flexible tongue being configured to cooperate with the tongue groove for locking together the first edge and the second edge in a second direction which is perpendicular to the junction plane
wherein the angle between the junction plane and the first main plane is about 45 °,
wherein the flexible tongue is displaceable in the insertion groove, and
wherein the first edge comprises a first edge surface which is parallel to the junction plane, and the second edge comprises a second edge surface which is parallel to the junction plane, wherein the first edge surface is configured to cooperate with the second edge surface.

US Pat. No. 10,506,874

TABLE APPARATUS AND METHOD

Halcon Corp., Stewartvil...

1. A table assembly, comprising:a table top defining a table peripheral edge and a lower surface; and
a sub-top positioned below the lower surface of the table top, the sub-top defining a protective peripheral edge extending outwardly beyond the table peripheral edge by a first distance, wherein the sub-top comprises a first material that is softer than the table top,
wherein the sub-top further comprises an electronics connector,
wherein the electronics connector is positioned below the protective edge on an exterior face of the sub-top, and wherein an exterior face of the electronics connector is flush with the exterior face of the sub-top.

US Pat. No. 10,506,870

TABLE AND TABLE CONNECTOR SYSTEM

BCG DESIGN GROUP LIMITED,...

1. A connecting system for releasably securing a first table top with a second table top, said system comprising at least one male member to be secured to the first table top and the second table top, and two receptacles to be associated with the first table top and second table top within which the male member can slide to a position securing the first and second table tops together,said male member carrying at least one deflectable barb, said barb being moveable between:
a) a non-deflected condition, wherein sliding of the male member within the receptacle to separate the male member from the receptacle is inhibited by interference between the receptacle and the barb, and
b) a deflected condition, wherein no interference exists between the receptacle and the barb,
wherein the receptacle engages with said barb during movement of the male member into the receptacle to urge the barb toward the deflected condition, thus permitting sliding of the male member to the position securing the first and second table tops together at where the barb is permitted to return to the non-deflected condition to prevent withdrawal of the male member from the receptacle
and wherein the receptacles are configured to permit access to the barb when the male member is in the position securing the first table top and second table top so that the barb can be urged to the deflected condition by an external member to allow the male member to slide and allow its withdrawal from either or both receptacles,
wherein the two receptacles are a first receptacle and second receptacle, the first receptacle to be associated with the first table top, and the second receptacle to be associated with the second table top, and wherein said male member is elongate and the male member can bridge between said first and second table tops, the male member carries two said barbs each for engagement with a respective one of said first and second receptacles so that when so engaged thereto, the table tops are secured together.

US Pat. No. 10,506,862

PULL DOWN PUMP ACTUATOR

HCT GROUP HOLDINGS LIMITE...

1. A device for dispensing and applying a cosmetic product, the device comprising:a container configured to hold a volume of cosmetic product, the container having a closed end at a lower end of the device and an open end facing an upper end of the device; and
a cosmetic dispensing system coupled to the open end of the container and comprising:
a tip having an outlet for dispensing cosmetic product; and
an actuator configured to be manually depressed to deliver a portion of the volume of cosmetic product to the outlet, wherein the actuator includes finger guides on opposite sides of the actuator, the finger guides disposed below the tip and providing opposing surfaces for depressing the actuator to move the actuator towards the lower end of the device; and
wherein the finger guides each extend generally parallel to a longitudinal axis of the cosmetic dispensing system.

US Pat. No. 10,506,855

HANDBAGS

Henry Charles LLC, San M...

1. A cosmetic bag, comprising:a hanging coupling element having a notched tab coupled thereto;
an elongate member comprising a first end and a second end, the first end coupled to the hanging coupling element; and
one or more compartments each comprising:
a body,
a lid,
one or more notched tabs, and
a bar,
wherein a first notched tab on a first compartment is configured to couple to the notched tab coupled to the hanging coupling element and a first bar on the first compartment is configured to couple to a second notched tab on a second compartment, and
wherein the cosmetic bag is transitionable between a first unrolled configuration and a second rolled configuration where the elongate member is configured to extend around the one or more compartments so that the second end of the elongate member also couples to the hanging coupling element.

US Pat. No. 10,506,830

AIR FLOW DESIGN FOR AN E-VAPING CARTRIDGE, METHOD OF MAKING THE E-VAPING CARTRIDGE, AND E-VAPING DEVICE INCLUDING THE CARTRIDGE

Altria Client Services LL...

1. A cartridge, comprising:a housing;
a reservoir within the housing, the reservoir configured to contain a pre-vapor formulation;
a tube extending longitudinally within the housing, the tube at least partially defining a central airflow passage, the central airflow passage including a first portion, a second portion and a third portion, the first portion, the second portion and the third portion of the central airflow passage being in communication with each other;
a vapor generator in communication with the first portion of the central airflow passage, the vapor generator configured to communicate the pre-vapor formulation from the reservoir to the first portion of the central airflow passage and at least partially vaporize the pre-vapor formulation into a vapor;
a first air inlet in communication with the second portion of the central airflow passage, the second portion of the central airflow passage being between the vapor generator and the first air inlet;
a dilution air inlet intersecting the third portion of the central airflow passage, the third portion of the central airflow passage being between the vapor generator and an outlet of the cartridge, the dilution air inlet defining a dilution air passage that does not pass through the vapor generator; and
an airflow restrictor within the central airflow passage, the airflow restrictor being positioned in the third portion of the central airflow passage, the dilution air inlet intersecting the third portion of the central airflow passage between the outlet of the cartridge and a discharge end of the airflow restrictor.

US Pat. No. 10,506,819

LOW-FAT WATER-IN-OIL EMULSION

Cargill, Incorporated, W...

1. A low-fat water-in-oil (W/O) emulsion comprising a fat phase in an amount of at most 40 wt % relative to the total weight of the emulsion, an aqueous phase dispersed within the fat phase and an emulsifier composition, said emulsifier composition comprising an Acetone-insoluble (AI) component containing a Phosphatidyl Choline (PC), a Phosphatidyl Inositol (PI), a Phosphatidyl Ethanolamine (PE) and a Phosphatidic Acid (PA), wherein PC is in an amount of at most 15.5% relative to the total weight of the emulsifier composition and wherein the emulsifier composition is characterized by a weight ratio R of at most 65%, the ratio R being defined according to Formula 1:wherein PC+PI+PE+PA is the sum of the individual weights of the respective constituents of the AI component and AI is the total weight of the AI component; andwherein the emulsifier composition is characterized by a ratio P3 of at most 0.50, wherein P3 is defined according to Formula 4:

US Pat. No. 10,506,817

FILTRATION SYSTEM

PACE INTERNATIONAL, LLC, ...

1. A method for filtration, comprising: arranging fruits in a substantially closed room having a volume of air; introducing post-harvest chemicals selected from the group consisting of thiabendazole, fludioxonil and a mixture thereof, and optionally, additional treatment substances, into an airstream with a thermo-fogger gun to generate air-borne treatment substances at a rate of up to 80 cubic feet per minute;introducing the airstream and the air-borne treatment substances into the volume of air of the substantially closed room to generate the dispersed air-borne substances;
creating with a fan a pressure between ?0.25 and 0 inches water column upon a bank of at least six high particle-rated pleated fiber filters; and
inducing an exhaust air current that flows from the substantially closed room into an exhaust port of the substantially closed room, wherein the exhaust air current includes the air-borne substances from the exhaust port and the filter bank captures at least around 95 percent of the air-borne treatment substances.

US Pat. No. 10,506,807

HALOGEN-SUBSTITUTED PHENOXYPHENYLAMIDINES AND THE USE THEREOF AS FUNGICIDES

BAYER CROPSCIENCE AKTIENG...

1. A phenoxyphenylamidine of formula (I)
wherein
R1 is selected from the group consisting of halogen and halomethyl;
R2 is methyl;
R3 is halogen;
and/or a salt and/or a stereoisomer thereof.

US Pat. No. 10,506,799

BIRD PROPELLED ROTATING HUMMINGBIRD FEEDER

1. A bird propelled rotating hummingbird feeder comprising:a pivot housing having a central axis and a central hole;
a plurality of fins configured as at least two symmetrical opposing fin sets, where each fin is angled at an oblique angle with respect to a plane passing perpendicularly through the central axis;
wherein each fin set comprises at least three angled fins, the at least three angled fins include a central fin and two outside fins, attached to the pivot housing so as to be symmetrically located opposite the other dual opposing fin set with the pivot housing centered between the dual opposing fin sets;
at least two feeder jar housings integrated into each of the dual opposing fin sets central fin;
a pivot cable inserted through the central hole;
a bearing element attached to a bottom end of the pivot cable within the pivot housing; and
a hanger attached to a top end of the pivot cable.

US Pat. No. 10,506,768

DEVICE AND METHOD FOR REMOVING LEAVES FROM A PLANT

1. A device for removing leaves from a plant, comprising:a downward extending and elongate support surface for supporting the plant;
a pair of cutting devices disposed on either side of the support surface, wherein each cutting device comprises a rotatable blade assembly and a grating which is disposed between the blade assembly and the support surface;
a frame on which are mounted the pair of cutting devices and the support surface, wherein the frame is configured to be placed on a ground surface;
wherein each cutting device is configured to at least one of cut and pull the leaves of the plant which protrude at least partially through the grating from the remaining part of the plant.

US Pat. No. 10,506,767

INSTALLATION EVALUATION APPARATUS FOR GREENHOUSE, INSOLATION REGULATION APPARATUS FOR GREENHOUSE, AND PROGRAM

Panasonic Intellectual Pr...

1. An installation evaluation apparatus for a greenhouse, comprising:an input device into which position information relating to a planned location for installing the greenhouse is input;
an insolation evaluation unit that determines variation, according to a date and time, in an insolation amount in the planned location by performing a computer simulation using the position information input into the input device;
a presentation device that visualizes and presents the variation in the insolation amount according to the date and time, determined by the insolation evaluation unit; and
a region extraction unit that extracts a region, in which the insolation amount satisfies a determination condition, using the variation in the insolation amount according to the date and time, determined by the insolation evaluation unit,
wherein the presentation device is configured to visualize and present the region extracted by the region extraction unit.

US Pat. No. 10,506,765

INTELLIGENT LIGHT ADJUSTING SYSTEM AND INTELLIGENT LIGHT ADJUSTING METHOD IN CROP GROWTH PROCESS

BOE TECHNOLOGY GROUP CO.,...

1. An intelligent light adjusting system useable in a crop growth process, the intelligent light adjusting system comprising: a parameter measurement device, a parameter processing device, a light source control device and a light source assembly, whereinthe parameter measurement device is configured to measure a specified parameter in the crop growth process;
the parameter processing device is configured to acquire a light source parameter of the light source control device, based on the specified parameter; and
the light source control device is configured to control lighting of the light source assembly, based on the light source parameter,
wherein the parameter measurement device comprises: a photosensitive element, a sensor element, a signal conditioning and converting circuit and an auxiliary circuit, wherein
the photosensitive element is configured to sense light, convert the sensed light into a valid optical signal and transmit the valid optical signal to the sensor element;
the sensing element is configured to convert the valid optical signal into an electrical signal and transmit the electrical signal to the signal conditioning and converting circuit;
the signal conditioning and converting circuit is configured to amplify a valid signal in the electrical signal and filtering out an invalid noise signal from the electrical signal to obtain a valid electrical signal, and transmit the valid electrical signal to the parameter processing device; and
the auxiliary circuit is configured to compare an output of the sensor element and an output of the signal conditioning and converting circuit and give feedback,
wherein the valid optical signal corresponds to the specified parameter.
US Pat. No. 10,507,216

METHOD FOR OLFACTORY IMPROVEMENT WITH SACCHARIDE

Tsung-Wei Huang, New Tai...

1. A method of improving olfactory function, which includes: administering an effective amount of saccharide to a subject suffering from olfactory disorder; and administering an effective amount of neuropeptide Y to the subject suffering from olfactory disorder, wherein the saccharide is a chitin-based material, proteoglycan, glycosaminoglycan, amino monosaccharide, N-acylated amino monosaccharide or a combination thereof.
US Pat. No. 10,508,242

VAPOR PHASE HYDROCARBON EXTRACTION OF OIL FROM OIL SAND

EPIC OIL EXTRACTORS, LLC,...

1. A partial extraction process for producing a high quality crude oil composition from oil sand, comprising:a) supplying oil sand containing bitumen to a contact zone of an extraction vessel, wherein the oil sand supplied to the contact zone has an average particle size of not greater than 20,000 microns and the bitumen is comprised of a flowable oil component, volatile hydrocarbons and asphaltene;
b) moving the particles of oil sand through the contact zone of the extraction vessel;
c) injecting a solvent blend into the extraction vessel, wherein the solvent blend has the following properties:
(i) is a hydrocarbon mixture comprised of at least two hydrocarbons selected from the group consisting of propane, butane and pentane,
(ii) has a Hansen dispersion blend parameter of not greater than 15,
(iii) has a Hansen polarity blend parameter of not greater than 1,
(iv) has a Hansen hydrogen bonding blend parameter of not greater than 1,
(v) has an ASTM D86 10% distillation point within the range of from ?45?C to 50° C., and
(vi) has an ASTM D86 90% distillation point of not greater than 300° C.;
d) treating the oil sand particles moving through the contact zone of the extraction vessel in step b) with the solvent blend in the contact zone of the extraction vessel as a vapor phase treatment, wherein
(i) not greater than 80 wt % of the bitumen is extracted from the supplied oil sand to produce an extracted crude oil composition and treated oil sand, with the treated oil sand containing unextracted bitumen comprised of asphaltenes,
(ii) the contact zone is at a temperature and pressure in which at least 20 wt % of the solvent injected into the extraction vessel is in vapor phase during treatment of the particles of oil sand with the solvent in the contact zone of the extraction vessel, with the contact zone temperature being at least 35° C., and
(iii) no water is used in extracting the crude oil composition;
e) removing the extracted crude oil composition from the extraction vessel, wherein the extracted crude oil composition comprises the high quality crude oil product and at least a portion of the solvent injected into the extraction vessel; and
f) separating at least a portion of the solvent from the extracted crude oil composition removed from the extraction vessel in step e) to recover the high quality crude oil product and a recycle solvent, wherein
(i) the high quality crude oil product is defined as having a nickel plus vanadium content of not greater than 100 wppm, an asphaltene content of not greater than 5 wt % and an API gravity of at least 12, and
(ii) the recycle solvent has each of the Hansen solubility characteristics and each of the distillation point ranges within 20% of the solvent properties defined in step c).
US Pat. No. 10,507,219

METHODS AND COMPOSITIONS FOR DOSING IN ADOPTIVE CELL THERAPY

JUNO THERAPEUTICS, INC., ...

1. A method of treatment, comprising:administering a consecutive dose of T cells expressing a chimeric antigen receptor (CAR) that binds CD19 to a subject having a hematologic malignancy expressing CD19 and that has been previously administered a first dose of T cells expressing a CAR that binds CD19, said first dose comprising no more than about 1×106 of the CAR-expressing cells per kilogram body weight of the subject, no more than about 1×108 of the CAR-expressing cells, or no more than about 1×108 of the CAR-expressing cells/m2 of the subject, wherein:
the CAR expressed by the cells in the first dose and the CAR expressed by the cells of the consecutive dose each, individually, comprises (i) an antigen binding domain that binds CD19; and (ii) an intracellular signaling region comprising an immunoreceptor tyrosine-based activation motif (ITAM) and a T cell co-stimulatory signaling domain; and
the consecutive dose of cells is administered at a point in time that is at least or more than about 14 days after and less than about 28 days after initiation of the administration of the first dose of cells.
US Pat. No. 10,508,247

PROCESS OF MAXIMIZING PRODUCTION OF CHEMICAL RAW MATERIALS BY GASEOUS PHASE CATALYTIC CRACKING CRUDE OIL WITH MULTI-STAGES IN MILLISECONDS IN COMBINATION WITH HYDROGENATION

CHINA UNIVERSITY OF PETRO...

1. A process of maximizing production of chemical raw materials by gaseous phase catalytic cracking crude oil with multi-stages in milliseconds in combination with hydrogenation, the process comprising:1) spraying crude oil, or a crude oil mix, preheated to 150° C.-350° C. with an atomizing nozzle, producing an oil mist, from a feed inlet of a downflow modification reaction tube into an upper portion of the downflow modification reaction tube, mixing the oil mist with a solid heat carrier at a temperature ranging from 650° C.-1,200° C. flowing downward from a first return controller for milliseconds, so as to heat, vaporize and pyrolyze the oil mist and obtain an oil and gas, and a solid heat carrier to be regenerated, wherein the pyrolysis reaction temperature is within a range of 480° C.?850° C. and the downflow modification reaction tube comprises a top and a bottom;
2) carrying out a gas-solid separation by allowing the oil and gas as well as the solid heat carrier to be regenerated to flow rapidly and downward to a first gas-solid separator at the bottom of the downflow modification reaction tube to carry out the gas-solid separation to obtain a coked solid heat carrier to be regenerated and a separated oil and gas;
3-1) allowing the coked solid heat carrier to be regenerated to flow through a first flow controller and enter into a lower portion of a modification regeneration reactor to conduct a regeneration reaction with a regeneration agent and produce a regeneration gas and a regenerated solid heat carrier, the temperature of the regeneration reaction within a range of 680° C.-1,250° C.; then subjecting the regeneration gas and the separated solid heat carrier to a gas-solid separation in a second gas-solid separator on top of the modification regeneration reactor to produce a regenerated solid heat carrier with a carrier/oil ratio of 1-14, then recirculating the regenerated solid heat carrier with a carrier/oil ratio of 1-14 through the first return controller, into the top of the downflow modification reaction tube, and into the downflow modification reaction tube so as to participate in the heating, vaporizing, and pyrolyzing of the oil mist; and subjecting the regeneration gas, after the second gas-solid separator on top of the modification regeneration reactor, to heat exchange and then output;
3-2) allowing the separated oil and gas, which is not condensed, from the first gas-solid separator to directly flow in the gaseous phase into a millisecond cracking reactor, and mix with a regeneration cracking catalyst having a temperature of 600° C.-850° C. to carry out a gaseous phase catalytic cracking reaction producing a cracking oil and gas and a cracking catalyst to be regenerated, the temperature of the gaseous phase catalytic cracking reaction is within a range of 530° C.?750° C., then subjecting the cracking oil and gas and a cracking catalyst to be regenerated to gas-solid separation in milliseconds;
4-1) allowing the cracking catalyst to be regenerated to flow through a second flow controller and enter a lower portion of a crack regeneration reactor for performing a regeneration reaction with air to produce a regenerated crack catalyst, the temperature of the regeneration reaction is 630° C.-900° C., subjecting a flue gas and the regenerated crack catalyst to a gas-solid separation in a third gas-solid separator at the top of the crack regeneration reactor to produce a crack catalyst with a catalyst/oil ratio of 1-8; passing the crack catalyst with a catalyst/oil ratio of 1-8 through a second return controller and into the millisecond cracking reactor to participate in the gaseous phase catalytic cracking reaction, and subjecting the flue gas to heat exchange and then output;
4-2) passing the cracking oil and gas into a catalytic fractionation tower and separating the cracking oil and gas in the catalytic fractionation tower into different fraction products, which are cracked gas, gasoline fraction, diesel fraction, recycle oil and oil slurry;
5-1) separating the cracked gas to obtain low-carbon olefins,
5-2) extracting and separating the gasoline fraction to obtain low-carbon aromatic hydrocarbons and a gasoline fraction raffinate oil;
5-3) mixing the diesel fraction with the recycle oil and the oil slurry to carry out catalytic saturation or open-ring reaction with a hydrogenation catalyst to obtain a hydrogenated modified oil, mixing the hydrogenated modified oil with the gasoline fraction raffinate oil to obtain a mixture, and returning the mixture to mix with the crude oil to form the crude oil mix, which enters the upper portion of the downflow modification reaction tube for mixing with at least one of the solid heat carrier or the regenerated solid heat carrier with a carrier/oil ratio of 1-14.
US Pat. No. 10,508,248

LUBRICANT COMPOSITION FOR HIGH-TEMPERATURE APPLICATIONS

1. A lubricant composition, comprising:a base oil comprising a mixture of at least one polyol ester and at least one pyromellitate ester, wherein the polyol ester is present in an amount of about 32% to about 36% by weight of the lubricant composition and the pyromellitate ester is present in an amount of about 63% to about 65% by weight of the lubricant composition, and
one or more additives,
wherein, after at least 68 hours at a temperature of 240° C., the lubricant composition has a liquid fraction of at least about 50 percent.
US Pat. No. 10,507,227

CATIONIC ANTIMICROBIAL PEPTIDES

The Hospital for Sick Chi...

1. A method for penetrating a bacterial biofilm, the method comprising administering a peptide to a biofilm, the peptide consisting of the amino acid sequence KKKKKKAAFAAWAAFAA-NH2 (SEQ ID NO:3), wherein penetrating comprises binding to and passing through the bacterial biofilm.
US Pat. No. 10,511,068

PROCESS FOR RECOVERING AN ELECTROLYTE SALT

RHODIA OPERATIONS, Paris...

1. A process for recovering a metal salt, wherein the metal salt is selected from the group consisting of potassium, lithium, and sodium sulfonimides, of an electrolyte dissolved in a matrix, said process consisting in subjecting the electrolyte to a liquid extraction with water when the matrix comprises a polymer or a gel, and when the matrix of the electrolyte comprises an organic solvent, the electrolyte is successively or simultaneously subjected to a liquid extraction with water and with a chlorinated organic extraction solvent which is water-immiscible, wherein the ratio by volume of water relative to the organic solvent and/or chlorinated organic extraction solvent is between 20:80 and 80:20, and recovering substantially all the metal salt dissolved in the aqueous phase.
US Pat. No. 10,508,262

ACTIVATION OF IMMUNE CELLS

Breakthrough Tech LLC, A...

1. A method of activating immune cells of a subject, the method comprising:obtaining bone marrow of the subject, the bone marrow comprising immune cells;
incubating the bone marrow with a non-ionic hydrophilic branched polysaccharide and a TLR2 ligand, wherein the non-ionic hydrophilic branched polysaccharide comprises poly(sucrose-co-epichlorhydrin),
wherein the non-ionic hydrophilic branched polysaccharide is at a concentration, wherein, if the bone marrow is contacted with whole blood and centrifuged, said concentration is sufficient to permit fluid movement of whole blood through the non-ionic hydrophilic branched polysaccharide without separation of erythrocytes,
wherein the non-ionic hydrophilic branched polysaccharide has a molecular weight greater than 20 kDa, and
wherein the incubating is performed until the immune cells are activated; and
administering the activated immune cells to the subject.
US Pat. No. 10,507,244

ANTI-TIGIT ANTIGEN-BINDING PROTEINS AND METHODS OF USE THEREOF

Potenza Therapeutics, Inc...

1. A method of enhancing an immune response in a human subject in need thereof, comprising administering to the subject an effective amount of an isolated antibody that specifically binds human TIGIT (hTIGIT; SEQ ID NO: 1), comprising a heavy chain variable (VH) domain comprising from N-terminus to C-terminus, CDR-H1, CDR-H2, and CDR-H3; and a light chain variable (VL) domain comprising from N-terminus to C-terminus CDR-L1, CDR-L2, and CDR-L3, wherein the CDRs of the VH and VL comprise the following six CDR sequences:(a) a CDR-H3 having the sequence A-R-D-G-V-L-X1-L-N-K-R-S-F-D-I, wherein X1 is A or T (SEQ ID NO: 128);
(b) a CDR-H2 having the sequence S-I-Y-Y-S-G-X2-T-Y-Y-N-P-S-L-K-S, wherein X2 is S, Q or G (SEQ ID NO: 129);
(c) a CDR-H1 having the sequence G-S-I-X3-S-G-X4-Y-Y-W-G, wherein X3 is E or A, and X4 is L, V or S (SEQ ID NO: 130);
(d) a CDR-L3 having the sequence QQHTVRPPLT (SEQ ID NO: 64);
(e) a CDR-L2 having the sequence GASSRAT (SEQ ID NO: 68); and
(f) a CDR-L1 having the sequence RASQSVSSSYLA (SEQ ID NO: 71),
or a pharmaceutical composition thereof, and further comprising administering at least one additional therapeutic agent.
US Pat. No. 10,509,036

METHODS OF SELECTING AND ISOLATING CANCER STEM CELLS

THE REGENTS OF THE UNIVER...

1. A method for selecting cancer stem cells from a sample, the method comprising (a) incubating the sample with a fluorescent glucose analog under suitable conditions, wherein the sample is a biological sample obtained from a subject with acute lymphoblastic leukemia (ALL) or a cell culture sample comprising cells from an ALL cell line, and wherein the sample comprises cancer stem cells and non-cancer stem cells; b) measuring or detecting the level of fluorescence in the sample; and (c) selecting the cancer stem cells from the sample based upon a lower level of fluorescence compared to the non-cancer stem cells.
US Pat. No. 10,507,247

OPTICAL PROBES FOR MATRIX METALLOPROTEINASES

The University of the Uni...

1. An optical probe comprising at least one fluorophore connected to at least one quencher by an enzyme cleavable peptide sequence; the at least one fluorophore being substantially fluorescently quenched by the at least one quencher when connected to the enzyme cleavable peptide sequence; wherein the at least one fluorophore is separated from the at least one quencher when the enzyme cleavable peptide sequence of at least one probe element is cleaved; wherein the enzyme cleavable peptide sequence is an amino acid sequence of SEQ ID NO:7 and is selectively cleavable by one or more matrix metalloproteinase (MMP).
US Pat. No. 10,508,274

PROTEIN AND PEPTIDE LIBRARIES

The General Hospital Corp...

1. A method for linking an mRNA molecule to a polypeptide, the method comprising:(a) providing an mRNA molecule comprising a reactive nucleoside that is reactive with a crosslinker, wherein the crosslinker is an S-4 alkylated thiouridine comprising N-(2-acetamidophenyl)-2-bromoacetamide at the S-4 position of the alkylated thiouridine;
(b) providing a translation system comprising a linking aminoacyl-tRNA comprising an amino acid residue linked to a linking tRNA by an amide bond, wherein the linking tRNA comprises an anticodon comprising the crosslinker;
(c) translating the mRNA molecule in the translation system to produce a polypeptide into which the amino acid residue, still linked to the tRNA, is incorporated; and
(d) during or after step (c), crosslinking the reactive nucleoside of the mRNA molecule to the crosslinker of the anticodon of the linking tRNA, thereby linking the mRNA molecule to the polypeptide through the linking tRNA.
US Pat. No. 10,507,254

IMAGE-GUIDED RADIOTHERAPY METHOD FOR TREATING A SUBJECT HAVING A TUMOR

National Guard Health Aff...

1. An image-guided radiotherapy method for treating a subject having a tumor, comprising:injecting a biocompatible curable composition into the subject at a tumor location such that the biocompatible curable composition is in contact with a border of the tumor, wherein the biocompatible curable composition crosslinks upon exposure to an aqueous solution or moisture to form a three-dimensional cured nanocomposite which is covalently bonded to the border of the tumor and forms a tissue spacer to separate the tumor from non-tumor tissue proximal to the tumor;
imaging the three-dimensional cured nanocomposite by at least one of magnetic resonance imaging, computed tomography, ultrasound, and X-ray, wherein the border of the tumor is detected; and
exposing the three-dimensional cured nanocomposite to radiation to weaken or destroy cells in the tumor;
wherein the biocompatible curable composition comprises:
an organic polymer comprising at least one hydrolysable functional group selected from the group consisting of a silane and an isocyanate;
a solvent selected from the group consisting of hexane and toluene; and
a metallic nanoparticle, wherein the metallic nanoparticle is at least one of a manganese-based nanoparticle and a gadolinium-based nanoparticle, and is dispersed in the organic polymer and the solvent at a weight percent relative to the total weight of the biocompatible curable composition of 0.1% to 30%.
US Pat. No. 10,508,278

SORTILIN 1 IS A NOVEL INDUCER OF VASCULAR CALCIFICATION

1. A method for inhibiting calcification of a smooth muscle cell (SMC), the method comprising contacting an anti-sortilin antibody or an antigen binding fragment thereof with a SMC, wherein the compound antibody or antigen binding fragment thereof inhibits activity or amount of sortilin 1 in the smooth muscle cell.
US Pat. No. 10,508,281

DISRUPTION OF ROCK1 GENE LEADS TO PLANTS WITH IMPROVED TRAITS

1. A method for producing a plant with an improved yield-related trait the method comprising:introducing into the genome of a plant cell a disruption of endogenous ROCK1 gene, wherein said disruption inhibits expression and/or activity of a product of said endogenous ROCK1 gene compared to a corresponding plant cell lacking such a disruption, wherein the endogenous ROCK1 gene comprises:(a) a nucleic acid encoding a ROCK1 protein comprising the amino acid sequence of SEQ ID NO: 1 or 2 or an orthologue thereof;(b) a nucleic acid encoding a ROCK1 protein comprising an amino acid sequence with a sequence identity of at least 55% over the entire amino acid sequence with SEQ ID NO: 1 or 2;(c) a nucleic acid comprising one of the nucleic acid sequences with SEQ ID NO: 4, 5, 6, 7 and/or 8;(d) a nucleic acid comprising a nucleic acid with a sequence identity of at least 60% over the entire nucleic acid sequence with one of SEQ ID NO: 4, 5, 6, 7 and/or 8; or(e) a nucleic acid hybridizing under stringent conditions to one of the nucleic acid sequences defined under (a), (b), (c), and/or (d);regenerating a plant having such an altered genome from said plant cell; and
measuring a yield-related trait of said plant compared to a plant lacking such disruption, wherein the yield-related trait is selected from the group consisting of: number of flowers, number of siliques, shoot growth, and seed yield.
US Pat. No. 10,507,269

CATHETER LOCK SOLUTION FORMULATIONS

Medline Industries, Inc.,...

1. A catheter locking method comprising: introducing a locking composition into a lumen of the implantable catheter, wherein the locking composition comprises:ethanol;
an anti-coagulant comprising sodium citrate; and
an excipient that is liquid at room temperature, wherein the excipient comprises one or more of glycerol, polysorbate-20, polysorbate-80, polyethylene glycol-100, polyethylene glycol-200, polyethylene glycol-300, polyethylene glycol-400, poloxomer 124, macrogol 15 hydroxy stearate, polyoxyl 35 castor oil, and t-octylphenoxypolyethoxyethanol, the amount of the excipient being less than the amount of the anti-coagulant and being sufficient to inhibit crystallization of the sodium citrate.
US Pat. No. 10,508,295

GAMMA GLUTAMYL-VALINE SYNTHASE, AND METHOD FOR PRODUCING GAMMA GLUTAMYL-VALYL-GLYCINE

AJINOMOTO CO., INC., Tok...

1. A method for producing ?-Glu-Val-Gly and/or a salt thereof, the method comprising:contacting a protein and glutathione synthetase with Glu, Val, and Gly to produce ?-Glu-Val-Gly; and
collecting the produced ?-Glu-Val-Gly,
wherein the protein comprises an amino acid sequence having at least 97% sequence identity to the amino acid sequence of SEQ ID NO: 6, 10, or 16, and has ?-glutamylvaline synthetase activity, and
a ratio of ?-glutamylvaline synthetase activity of the protein to ?-glutamylglycine synthetase activity of the protein is 15 or higher.
US Pat. No. 10,508,297

METHOD FOR IMMOBILIZATION OF GLUCURONIDASE ENZYMES FOR THE DETECTION OF PRODUCTS DERIVED FROM GLUCURONIDE COMPOUNDS

1. An insoluble enzymatic reagent for detecting products derived from glucuronide metabolites in a sample, comprising a ?-glucuronidase enzyme originated from a bacterium of the genus Brachyspira sp., the enzyme being immobilized on a resin of a polysaccharide activated with an aldehyde functional group, wherein said polysaccharide is agarose and said aldehyde functional group is a glyoxyl group.
US Pat. No. 10,508,303

WHOLE-GENOME AND TARGETED HAPLOTYPE RECONSTRUCTION

LUDWIG INSTITUTE FOR CANC...

1. A method for haplotyping one or more chromosomes of a eukaryotic organism, the method comprising:providing a cell of the organism that contains a set of chromosomes having genomic DNA;
incubating the cell or the nuclei thereof with a fixation agent for a period of time to allow crosslinking of the genomic DNA in situ and thereby to form crosslinked genomic DNA;
fragmenting the crosslinked genomic DNA;
ligating the proximally located crosslinked and fragmented genomic DNA to form a proximally ligated complex having a first genomic DNA fragment and a second genomic DNA fragment,
wherein the first genomic DNA fragment and the second genomic DNA fragment are on the same chromosome, and
wherein the first genomic DNA fragment and the second genomic DNA fragment are apart in situ by at least 100 bp;
shearing the proximally ligated complex to form proximally-ligated DNA fragments;
obtaining a plurality of the proximally-ligated DNA fragments to form a library;
sequencing the plurality of the proximally-ligated DNA fragments to obtain a plurality of sequence reads and
assembling the plurality of sequence reads to construct a haplotype for one or more of the chromosomes.
US Pat. No. 10,507,282

MULTI-STAGE BIODEGRADABLE DRUG DELIVERY PLATFORM

InCube Labs, LLC, San Jo...

1. A method for drug delivery, the method comprising:lodging a drug delivery platform in a tissue layer beneath skin of a patient, the drug delivery platform containing at least a first dosage and a second dosage of therapeutic agent, the first dosage contained in a first biodegradable structure, wherein the first biodegradable structure comprises a core body, the second dosage contained in a second biodegradable structure, the second biodegradable structure being positioned inside the first biodegradable structure, the second biodegradable structure comprising a shell having a shell wall with a thickness of about 1 to about 20 thousandths of an inch and a weight of about 90 mg to about 150 mg;
biodegrading the first biodegradable structure in vivo over a first period of time until an integrity of the first biodegradable structure is degraded to release the first therapeutic agent dosage;
releasing the first dosage of therapeutic agent into the tissue of the patient;
biodegrading the second biodegradable structure in vivo over a second period of time, the second biodegradable structure configured to have a longer period of in vivo biodegradation than the first biodegradable structure, until an integrity of the second biodegradable structure is degraded to release the second dosage of therapeutic agent; and
releasing the second dosage of therapeutic agent into the tissue of the patient after release of the first dosage of therapeutic agent.
US Pat. No. 10,506,772

COTTON VARIETY PX333103W3FE

Phytogen Seed Company LLC...

1. A seed of cotton variety designated PX333103W3FE, or a regenerable part thereof, representative seed of the variety having been deposited under ATCC Accession No. PTA-123649 on Nov. 15, 2016.
US Pat. No. 10,508,313

COMPOSITIONS AND METHODS FOR DETECTING OR QUANTIFYING HEPATITIS B VIRUS

GEN-PROBE INCORPORATED, ...

1. An amplification oligomer comprising the sequence of SEQ ID NO: 2.
US Pat. No. 10,506,776

MAIZE INBRED PH262F

PIONEER HI-BRED INTERNATI...

1. A seed, plant, plant part, or plant cell of inbred maize variety PH262F, representative seed of the variety having been deposited under ATCC accession number PTA-125655.
US Pat. No. 10,506,777

MAIZE HYBRID X05M994

PIONEER HI-BRED INTERNATI...

1. A seed of hybrid maize variety X05M994, the seed produced by crossing a first plant of variety PH2S5H with a second plant of variety PH1W4R, wherein representative seed of the varieties PH2S5H and PH1W4R have been deposited under ATCC Accession Numbers PTA-124787 and PTA-121351, respectively.
US Pat. No. 10,506,779

PLANTS AND SEEDS OF HYBRID CORN VARIETY CH699670

Monsanto Technology LLC, ...

1. A seed of hybrid corn variety CH699670, produced by crossing a first plant of variety CV292720 with a second plant of variety CV589900, wherein representative seeds of said varieties CV292720 and CV589900 are deposited under ATCC Accession Nos. PTA-9834 and PTA-12078, respectively.
US Pat. No. 10,506,780

HYBRID CORN VARIETY 79586595

Agrigenetics, Inc., Indi...

1. A seed of the hybrid corn variety 79586595, produced by crossing a first plant of variety SLD34BM with a second plant of variety 7DBDD0188, wherein representative seed of said varieties SLD34BM and 7DBDD0188 have been deposited under ATCC Accession numbers PTA-124282 and PTA-124386, respectively.
US Pat. No. 10,508,319

METHOD AND SYSTEM FOR PRODUCING LOW CARBON FERROCHROME FROM CHROMITE ORE AND LOW CARBON FERROCHROME PRODUCED THEREBY

MM Metals USA, LLC, Plym...

1. A method for recovering low carbon ferrochrome from chromite ore comprising:feeding a mixture of feed materials comprising scrap aluminum granules, burnt lime, silica sand, and chromite ore into a plasma arc furnace, said scrap aluminum granules being produced from used beverage containers, said chromite ore containing chromium oxide and iron oxide, said feed materials being in a stoichiometric proportion for reduction of said chromium oxide and iron oxide to form low carbon ferrochrome;
heating said feed materials in said plasma arc furnace to a temperature in the range of approximately 1,650° C. to 1850° C. wherein said aluminum in said aluminum granules acts as a reducing agent to produce an exothermic reaction reducing said chromium oxide and iron oxide in said chromite ore to produce molten low carbon ferrochrome with molten slag floating on top of said molten low carbon ferrochrome; and
extracting said molten low carbon ferrochrome from said plasma arc furnace.
US Pat. No. 10,506,782

SOYBEAN VARIETY 5PLMK17

PIONEER HI-BRED INTERNATI...

1. A plant or a seed of soybean variety 5PLMK17, representative seed of the variety having been deposited under ATCC Accession Number PTA-125057.
US Pat. No. 10,508,320

PROCESS FOR RECOVERING PRIMARY METAL RESIDUE FROM A METAL-CONTAINING COMPOSITION

UNIVERSITY OF LEEDS, Lee...

1. A process for recovering a primary metal residue from a metal-containing composition comprising:(a) preparing a feedstock of the metal-containing composition and an alkali salt;
(b) reductively roasting the feedstock at a roasting temperature for a roasting period to produce a roast;
(c) cooling the roast to produce a roasted mass containing metallic iron or an alloy or compound thereof and soluble metal oxides;
(d) adding an aqueous medium to the roasted mass to form a substantially insoluble product and a first solution of soluble metal oxides;
(e) acid leaching the substantially insoluble product or a fraction thereof to produce a leach residue and a second solution of soluble metal oxides;
(f) roasting the leach residue in the presence of a bisulphate or bicarbonate of an alkali metal or alkaline earth metal to produce a roasted residue; and
(g) hydrometallurgically extracting from the roasted residue the primary metal residue and a third solution of soluble metal oxides.
US Pat. No. 10,506,783

SOYBEAN CULTIVAR 70391206

M.S. Technologies, L.L.C....

1. A plant of soybean cultivar 70391206, representative seed of said soybean cultivar having been deposited under ATCC Accession No. PTA-125376.
US Pat. No. 10,506,784

SOYBEAN CULTIVAR S170171

M.S. Technologies, L.L.C....

1. A plant of soybean cultivar S170171, representative seed of said soybean cultivar having been deposited under ATCC Accession No. PTA-125401.
US Pat. No. 10,506,785

SOYBEAN CULTIVAR S170122

M.S. Technologies, L.L.C....

1. A plant of soybean cultivar S170122, representative seed of said soybean cultivar having been deposited under ATCC Accession No. PTA-125444.
US Pat. No. 10,508,067

PROCESS FOR DEHYDROHALOGENATION OF HALOGENATED ALKANES

Honeywell International I...

1. A process for preparing a halogenated propene comprising:a. introducing an alkali-metal hydroxide feed stream into a reactor charged with at least one halogenated propane having a structure according to Formula I:
C3FxClyH8-x-y  (Formula I)
wherein x is 5 or 6 and y is 0 or 1, provided that x+y is ?6;
b. reacting, in a liquid phase, said at least one halogenated propane with said alkali-metal hydroxide in said reactor to produce a halogenated propene having a structure according to Formula II:
C3Fz-1H7-z  (Formula II)
wherein z is x?1; and
c. removing at least a portion of said halogenated propene from said reactor as a vapor product stream,
wherein steps (a), (b), and (c) are at least partially performed simultaneously.
US Pat. No. 10,508,069

ACID/SALT SEPARATION

PURAC BIOCHEM B.V., Gori...

1. A method for the recovery of a carboxylic acid that is not succinic acid, the method comprising:providing magnesium carboxylate, wherein the carboxylic acid corresponding with the carboxylate has a solubility in water at 20° C. of 80 g/100 g water or less;
acidifying the magnesium carboxylate with hydrogen chloride (HCl), thereby obtaining a solution comprising carboxylic acid and magnesium chloride (MgCl2);
precipitating the carboxylic acid from the solution comprising the carboxylic acid and MgCl2, thereby obtaining a carboxylic acid precipitate and a MgCl2 solution; and
thermally decomposing the MgCl2 solution at a temperature of at least 300° C., thereby decomposing the MgCl2 to magnesium oxide (MgO) and HCl.
US Pat. No. 10,508,326

HIGH-MANGANESE STEEL WITH SUPERIOR COATING ADHESION AND METHOD FOR MANUFACTURING HOT-DIP GALVANIZED STEEL FROM SAME

POSCO, Pohang-si (KR)

1. A hot-dip galvanized steel sheet comprising:a steel sheet comprising: by weight, C: 0.3-1%, Mn: 8-25%, Al: 1-8%, Si: 0.1-3.0%, Ti: 0.01-0.2%, Sn: 0.06-0.2%, B: 0.0005-0.01%, with the remainder being Fe and inevitable impurities, wherein the steel sheet has an Sn-precipitate layer formed on a surface of the steel sheet; and
a galvanized layer formed on the Sn-precipitate layer of the steel sheet.
US Pat. No. 10,506,789

SOYBEAN CULTIVAR 61381330

Monsanto Technology LLC, ...

1. A plant of soybean cultivar 61381330, representative seed of said soybean cultivar having been deposited under ATCC Accession No. PTA-125581.
US Pat. No. 10,506,790

PETUNIA-CALIBRACHOA VARIETY SAKPXC024

Sakata Seed Corporation, ...

1. A plant of Petunia-Calibrachoa variety SAKPXC024, wherein a representative sample of plant tissue of SAKPXC024 was deposited under NCMA No. 201907006.
US Pat. No. 10,508,073

METHOD FOR PREPARING ACETAL CARBONYL COMPOUND

Dalian Institute of Chemi...

1. A method for preparing acetal carbonyl compound used as an intermediate for producing ethylene glycol, which comprises a step in which a raw material acetal and carbon monoxide go through a reactor loaded with a catalyst for carrying out a carbonylation reaction; wherein the catalyst contains an acidic microporous silicoaluminophosphate molecular sieve; wherein the chemical composition of the acidic microporous silicoaluminophosphate molecular sieve is expressed as (SixAlyPz)O2, and x is in a range from 0.01 to 0.60, and y is in a range from 0.2 to 0.60, and z is in a range from 0.2 to 0.60, and x+y+z=1; wherein the raw material acetal is expressed as R1O(CH2O)nR2, and n is selected from 1, 2, 3 or 4, and R1 and R2 are independently selected from C1-C3 alkyls; wherein the acidic microporous silicoaluminophosphate molecular sieve is one or more molecular sieves selected from the molecular sieves with framework type of CHA, RHO, LEV, ERI, AEI or AFX.
US Pat. No. 10,508,344

STABILIZED ALKALINE HYDROGEN PEROXIDE FORMULATIONS

1. A formulation for stabilizing hydrogen peroxide, comprising water soluble Zn+2 ions in an ammonical solution at 0.7 to 100 parts per million of an alkaline hydrogen peroxide solution.
US Pat. No. 10,506,809

HERBICIDAL COMBINATION COMPRISING SAFLUFENACIL AND GLUFOSINATE

BASF SE, Ludwigshafen am...

1. A herbicidal combination comprising componentsa) a herbicide A which is 2-chloro-5-[3,6-dihydro-3-methyl-2,6-dioxo-4-(trifluoromethyl)-1-(2H)-pyrimidinyl]-4-fluoro-N-[[methyl-(1-methylethyl)-amino]sulfonyl]benzamide,
b) a herbicide B which is glufosinate or one of its salts, and
c) at least one herbicide C different from herbicides A and B which is selected from the group of diclosulam, cloransulam, flumetsulam, thiencarbazone, flumioxazin, butafenacil, carfentrazone, sulfentrazone, acifluorfen, fomesafen, lactofen, oxyfluorfen, quinclorac, fluroxypyr, 2,4-D, pendimethalin, fenoxaprop, haloxyfop, clethodim, sethoxydim, profoxydim, atrazine, metribuzin, bentazone, benzobicyclon, benzofenap, bicyclopyrone, clomazone, isoxaflutole, mesotrione, pyrasulfotole, pyrazolynate, pyrazoxyfen, sulcotrione, tefuryltrione, tembotrione, topramezone, acetochlor, metolachlor, metazachlor, and flufenacet and
or an agriculturally acceptable enantiomer, salt or ester thereof, wherein a herbicidal mixture of components a and b in combination with component c is synergistic.
US Pat. No. 10,508,094

METHODS FOR PRODUCING FERRIC MALTOL COMPOSITIONS FROM FERROUS HYDROXIDES

SHIELD TX (UK) LIMITED, ...

1. A method for producing a ferric maltol composition comprising reacting ferrous hydroxide with maltol and recovering the ferric maltol that forms.
US Pat. No. 10,506,824

SMOKING ARTICLE MOUTHPIECE WITH COOLING AGENT INCLUSION COMPLEX

1. A smoking article comprising;a mouthpiece having an outer surface; and
a cooling agent inclusion complex disposed on the outer surface wherein the cooling agent inclusion complex is a cyclodextrin cooling agent inclusion complex comprising cyclodextrin and a non-volatile cooling agent comprising a carboxamide containing compound.
US Pat. No. 10,508,106

BICYCLIC BET BROMODOMAIN INHIBITORS AND USES THEREOF

ConverGene LLC, Cambridg...

1. A compound, which is (S)-1-(4-(6-(3,5-dimethylisoxazol-4-yl)-4-(3-phenylmorpholino)quinazolin-2-yl)-1H-pyrazol-1-yl)-2-methylpropan-2-ol, or a pharmaceutically acceptable salt thereof.
US Pat. No. 10,507,608

POLYAMIDE MOULDING COMPOUNDS FOR LARGE MOULDED PARTS

1. A polyamide molding composition with the following composition:(A) 20 to 79% by weight of at least one semiaromatic polyamide in the form of a copolyamide which comprises from 65 to 73 mol % of units composed of hexanediamine and terephthalic acid,
(B) 1 to 15% by weight of at least one impact modifier,
(C) 20 to 60% by weight of at least one carbon fiber,
(D) 0 to 5% by weight of at least one additive,
where components (A) to (D) give a total of 100% by weight
wherein the copolyamide is in essence free from aliphatic diacids.
US Pat. No. 10,508,123

POLYMORPHS

Vectura Limited, Chippen...

1. A method of treating asthma or chronic obstructive pulmonary disease (COPD), comprising administering to a patient in need thereof a polymorph of (S)-3-(3-(1-methyl-2-oxo-5-(pyrazolo[1,5-a]pyridine-3-yl)-1H-imidazo[4,5-b]pyridine-3(2H)-yl)piperidin-1-yl)-3-oxopropanenitrile with the following diffraction angles (2Theta) based on cupric K?1:at approximately 8.25°;
at approximately 13.25°;
at approximately 15.40°;
at approximately 17.65°; and
at approximately 25.39°.
US Pat. No. 10,507,612

MARKED COMPOSITE MATERIAL AND METHOD FOR PRODUCING THE SAME

Teijin Limited, Osaka-Sh...

1. A method of applying laser marking on a composite material comprising a black pigment, carbon fibers, and a resin, and having the following 1) to 3):1) an area proportion of the carbon fibers in a topmost surface layer of the material from 10 to 90%,
2) a proportion of the black pigment contained in the composite material from 0.2 to 20% by mass, and
3) an average fiber length of the carbon fibers from 1 to 100 mm,
wherein the laser marking is applied using a YVO4 laser having a wavelength from 100 to 2,000 nm, an output density from 1.0 (mW/?m2) to 30 (mW/?m2), and an irradiation energy per pulse from 1000×10?5 (mWs) to 50,000×10?5 (mWs).
US Pat. No. 10,508,129

PHARMACEUTICAL TARGETING OF A MAMMALIAN CYCLIC DI-NUCLEOTIDE SIGNALING PATHWAY

THE BOARD OF REGENTS OF T...

1. An injectable pharmaceutical formulation comprising a pharmaceutically acceptable carrier containing a cyclic dinucleotide comprising a 5?-monophosphate nucleotide comprising a guanine moiety, and a 5?-monophosphate nucleotide comprising an adenine moiety, wherein the cyclic dinucleotide hasa phosphodiester bond between the 2?-OH of the nucleotide comprising the guanine moiety and the 5?-phosphate of the nucleotide comprising the adenine moiety, and
a phosphodiester bond between the 3?-OH of the nucleotide comprising the adenine moiety and the 5?-phosphate of the nucleotide comprising the guanine moiety.
US Pat. No. 10,508,387

CONDUCTIVE FIBRES

PIRETA LIMITED, Birmingh...

1. A method for making a fibre electrically conductive, comprising the steps of:(a) providing a fibre having a negative electric charge at the surface of the fibre,
(b) applying to the fibre a substance (referred to below as a ‘linker’) which provides a layer of said substance on the fibre and changes the electric charge at the surface of the fibre from negative to positive, wherein said substance is not chitosan, wherein said substance is a cationic polyelectrolyte,
(c) making the surface of the fibre electrically conductive with a metal,
wherein the metal of step (c) is provided in the form of metal cations and wherein the metal cations are reduced to elemental metal; and
(d) sintering the metal.
US Pat. No. 10,508,132

METHOD FOR PRODUCING AEROBIC-TYPE SINGLE CELL PROTEIN USING THE AUTOLYSIS PROCESS

Taizhou iCell Bio-Tech Co...

1. A method for producing an aerobic-type single cell protein from materials by an autolysis, comprising the following steps:(1) delivering bacterial proteins generated from a bioreactor to a conical concentration tank, and precipitating the bacterial proteins at the bottom of the conical concentration tank, wherein the material moisture content at the bottom is reduced to 97% or less for the subsequent dewatering process;
(2) pumping the materials at the bottom of the concentration tank to centrifugal dewatering equipment by a transfer pump;
(3) performing a solid-liquid separation using a horizontal spiral centrifuge, wherein the material moisture content is reduced to 78% to 85% and the materials are mud-like after the centrifugation;
(4) transferring the materials from step (3) to an autolysis device comprising twin-screw hollow blades, wherein the front ¼ to ½ of the twin-screw front hollow blade of the autolysis device is a heating section and the remaining section is a holding section and the device is preheated through the twin-screw hollow blades to an autolysis temperature of between 65° C. and 95° C. for a preheating time of 5 to 30 min; and carrying out an autolysis, comprising maintaining the materials in the autolysis device at a temperature between 65° C. and 95° C. for a time of 30 to 360 min;
(5) conveying the materials resulting from the autolysis through an auger feeder to air flash drying equipment for drying; wherein the contact temperature of the materials is between 65 and 100° C. and the moisture content of the materials after drying is between 10% and 40%;
(6) conveying the materials from step (5) to a tunnel type microwave drying sterilization apparatus by airflow lifting equipment for sterilization; wherein said materials after the microwave sterilization have a moisture content between 5% and 10%; and
(7) smashing and packaging the materials from step (6);
wherein the aerobic-type single cell protein has 33% -60% of protein, 0.1-1.4% free nucleotides, and 0-0.9% free base, and the ratio of free bases to free nucleotides is between 0 to 0.60.
US Pat. No. 10,508,138

POLYPEPTIDE CAPABLE OF BINDING TO VASCULAR ENDOTHELIAL GROWTH FACTOR, AND USE THEREOF

KOREA ADVANCED INSTITUTE ...

1. A polypeptide capable of binding to vascular endothelial growth factor (VEGF) comprising the amino acid sequence of any one of SEQ ID NOs: 3 to 8.
US Pat. No. 10,508,139

COMPOUND, USE, ANTI-TUMOR PHARMACEUTICAL COMPOSITION, GENE CONSTRUCT FOR POLYPEPTIDE EXPRESSION, PROCESS FOR THE PRODUCTION, PROCESS FOR THE EVALUATION OF TUMOR CELLS, METHOD OF SENSITIZATION OF TUMOR CELLS TO CHEMOTHERAPEUTIC

1. An anti-tumor pharmaceutical composition for extracellular administration comprising:pharmaceutically acceptable carrier;
at least one polypeptide consisting of SEQ ID No: 1; and
cisplatin.
US Pat. No. 10,508,141

NUCLEIC ACIDS ENCODING HLA-A24 AGONIST EPITOPES OF MUC1-C ONCOPROTEIN

The USA, as represented b...

1. An isolated nucleic acid encoding a peptide comprising the amino acid sequence of SEQ ID NO:1 or SEQ ID NO:2.
US Pat. No. 10,508,143

COMPOSITIONS AND METHODS FOR TREATMENT OF CANCER

Aleta Biotherapeutics Inc...

1. A T-cell comprising a constitutive expression construct encoding a secreted fusion protein comprising (a) an antibody, or antigen-binding fragment thereof, that binds a tumor antigen; and (b) an extracellular domain of CD19, or a fragment thereof, that includes an epitope recognized by the FMC63 anti-CD19 antibody.
US Pat. No. 10,507,632

PACKAGING FILM

1. A wrapper made of an unstretched at least single-layer polyolefin film which optionally has release properties, comprisinga) a layer (a) with thickness from 6 to ?20 ?m,
based on a mixture of ?) from 20 to 49% by weight of a polypropylene or of at least one propylene copolymer, or of a combination thereof, and
of ?) from 80 to 51% by weight of at least one polyethylene or ethylene copolymer, or of a combination thereof, and
optionally of ?) conventional auxiliaries,
wherein the ?) component has a VICAT temperature of at least 130° C., as measured by ASTM D 1525-00, Rate A (50° C./min), Loading 1 (10 N), and
b) optionally on at least one surface of the layer (a) a release coating (b) made of cured polysiloxane
and
c) optionally on at least one uncovered surface of the layer (a) an optionally sealable layer (c) with thickness from 4 to 10 ?m made of a thermoplastic polymer with melting point lower by at least 5° C. than the melting point of the layer (a),
wherein the tensile strength of the polyolefin film in machine direction is at least 6.5 N/cm, measured in accordance with DIN EN ISO 527-3.
US Pat. No. 10,508,144

CARBOHYDRATE CONTENT OF CTLA4 MOLECULES

Bristol-Myers Squibb Comp...

1. A composition comprising cytotoxic T lymphocyte antigen 4-Ig (CTLA4-Ig) molecules, wherein the CTLA4-Ig composition comprises(a) an average molar ratio of N-acetyl neuraminic acid (NANA) to CTLA4-Ig molecules of from about 8 to about 12, and
(b) less than or equal to 5.0 area percent high molecular weight species as determined by size exclusion chromatography and spectrophotometric detection,
wherein the CTLA4-Ig molecules are isolated from a soluble fraction of a liquid culture medium comprising an initial population of CTLA4-Ig molecules recombinantly produced by mammalian cells, wherein
(1) the CTLA4-Ig molecules of the initial population have one or more sialic acid residues;
(2) the number of sialic acid residues per CTLA4-Ig molecule varies within the initial population;
(3) the initial population comprises CTLA4-Ig dimers and high molecular weight aggregates;
(4) the liquid culture medium contains Monocyte Chemotactic Protein-1 (MCP-1); and,
(5) the CTLA4-Ig molecules comprise one or more polypeptides having the amino acid sequence set forth in SEQ ID NO: 2, 5, 6, 7, 8, 9, or 10,
wherein the CTLA4-Ig composition is obtainable by a method comprising:
(i) obtaining the soluble fraction of the liquid culture medium, wherein the liquid culture medium comprises mammalian cells that produce the initial population of CTLA4-Ig molecules; then
(ii) subjecting the soluble fraction of the liquid culture medium to affinity chromatography to reduce MCP-1 content; then
(iii) subjecting the composition of step (ii) to anion chromatography to separate the CTLA4-Ig molecules into two or more fractions, wherein at least one fraction has a greater molar ratio of sialic acid to CTLA4-Ig molecules compared to at least one other fraction; and then
(iv) subjecting the composition of step (iii) to hydrophobic interaction chromatography to separate CTLA4-Ig dimers from CTLA4-Ig high molecular weight aggregates.
US Pat. No. 10,508,148

ANTI-TREM2 ANTIBODIES AND RELATED METHODS

Pionyr Immunotherapeutics...

1. An isolated anti-TREM2 humanized antibody comprising a human IgG1 Fc, a heavy chain comprising a variable heavy (VH) chain sequence comprising three heavy chain CDR sequences, CDR-H1, CDR-H2, and CDR-H3, and a light chain comprising a variable light (VL) chain sequence comprising three light chain CDR sequences, CDR-L1, CDR-L2, and CDR-L3, wherein:a. CDR-H1 comprises the sequence set forth in SEQ ID NO: 9,
b. CDR-H2 comprises the sequence set forth in SEQ ID NO:10,
c. CDR-H3 comprises the sequence set forth in SEQ ID NO: 11,
d. CDR-L1 comprises the sequence set forth in SEQ ID NO: 12,
e. CDR-L2 comprises the sequence set forth in SEQ ID NO: 13, and
f. CDR-L3 comprises the sequence set forth in SEQ ID NO: 14.
US Pat. No. 10,508,149

ANTIBODIES DIRECTED AGAINST T CELL IMMUNOGLOBULIN AND MUCIN PROTEIN 3 (TIM-3)

AnaptysBio, Inc., San Di...

1. A T Cell Immunoglobulin and Mucin Domain-3 (TIM-3) binding agent comprisinga light chain CDR1 comprising RASQSIRRYLN (SEQ ID NO: 332);
a light chain CDR2 comprising GASTLQS (SEQ ID NO: 333);
a light chain CDR3 comprising QQSHSAPLT (SEQ ID NO: 334);
a heavy chain CDR1 comprising GFTFSSYDMS (SEQ ID NO: 329);
a heavy chain CDR2 comprising ISGGGTYTYYQDSVKG (SEQ ID NO: 330); and
a heavy chain CDR3 comprising MDY (SEQ ID NO: 331).
US Pat. No. 10,508,150

METHODS TO IMPAIR HEMATOLOGIC CANCER PROGENITOR CELLS AND COMPOUNDS RELATED THERETO

University of Kentucky Re...

1. A method for reducing the number of CD123-bearing leukemia cells in a human diagnosed with myelodysplastic syndrome, said method comprising administering to the human a therapeutically effective amount of an antibody that binds CD123, such that said administration causes a reduction in the number of leukemia cells in the human.
US Pat. No. 10,508,159

METHOD FOR PREPARING DIENE-BASED RUBBER LATEX AND ACRYLONITRILE-BUTADIENE-STYRENE GRAFT COPOLYMER COMPRISING THE SAME

LG CHEM, LTD., Seoul (KR...

1. A method for preparing diene-based rubber latex comprising:an initial step of an entire polymerization reaction comprising adding a conjugated diene-based monomer 60 parts by weight to 75 parts by weight, a first emulsifier 1 part by weight to 3 parts by weight, a polymerization initiator 0.2 part by weight to 0.4 part by weight, an electrolyte 0.2 part by weight to 3 parts by weight, a molecular weight control agent 0.1 part by weight to 0.5 part by weight and ion exchanged water 65 parts by weight to 100 parts by weight into a reactor and then polymerizing thereof;
a step of adding the conjugated diene-based monomer 10 parts by weight to 20 parts by weight and a second emulsifier 0.1 part by weight to 1.0 part by weight simultaneously at the time point that a polymerization conversion rate of the entire polymerization reaction is 30% to 40% and then polymerizing thereof;
a step of adding a residual amount of a conjugated diene-based monomer and optionally a third emulsifier 0 part by weight to 1 part by weight simultaneously or continuously at the time point that the polymerization conversion rate of the entire polymerization reaction is 60% to 70% and then polymerizing thereof;
a step of completing polymerization by adding a polymerization inhibitor at the time point that the polymerization conversion rate of the entire polymerization reaction is 92% or higher,
which further comprises a step of additionally adding a cross-linking agent 0.05 part by weight to 0.3 part by weight at the time point that the polymerization conversion rate of the entire polymerization reaction is 0% to 50%; and
which further comprises a step of adding a fourth emulsifier having critical micelle concentration (CMC) of 150 mg/L or less 0.01 part by weight to 0.5 part by weight at the time point that the polymerization conversion rate of the entire polymerization reaction is 50% to 85%.
US Pat. No. 10,508,167

GRAFT COPOLYMER AND THERMOPLASTIC RESIN COMPOSITION

1. A graft copolymer (A) obtainable by graft-polymerizing:an aromatic vinyl-based monomer (b) in an amount of 20 to 70 parts by mass, in the presence of 30 to 80 parts by mass of an ethylene-based polymer (a) provided that the sum of components (a) and (b) is 100 parts by mass; or
an aromatic vinyl-based monomer (b) and another vinyl-based monomer (c) copolymerizable with the aromatic vinyl-based monomer (b) in a total amount of 20 to 70 parts by mass, in the presence of 30 to 80 parts by mass of an ethylene-based polymer (a) provided that the sum of components (a), (b) and (c) is 100 parts by mass,
wherein the ethylene-based polymer (a) has a density of 0.900 g/cm3 or more and less than 0.966 g/cm3, a number average molecular weight of 10,000 to 50,000, and a molecular weight distribution of 5 to 15, and the proportion of the ethylene-based polymer (a) molecules having a molecular weight of 10,000 or less is 5.5% or more.
US Pat. No. 10,508,188

ANTIMICROBIAL AND ANTIFUNGAL POLYMER FIBERS, FABRICS, AND METHODS OF MANUFACTURE THEREOF

PurThread Technologies, I...

1. A polymer composition comprising:(a) a polymer;
(b) about 1 to about 26 wt. % of a silver salt having the formula AgaXbYcZd;
(c) about 0.1 to about 2.6 wt. % of a copper salt having the formula CuaXbYcZd; and
(d) one or more additives;
Ag is Ag(I) or Ag(II), and a is 1 to 4;
each X is sulfur, and b is independently 1 to 4;
each Y is oxygen, and c is independently 2 to 8;
each Z is independently H; C1-C14 alkyl; C3-C8 cycloalkyl; C1-C8 alkyl substituted by C3-C6 cycloalkyl; C1-C8 alkyl optionally substituted by C6-C10 aryl; C6-C10 aryl; C6-C10 aryl substituted by C1-C14 alkyl, C3-C8 cycloalkyl, C1-C8 alkyl substituted by C3-C6 cycloalkyl, or halogen;
d is 0 or 1;
wherein each of the silver salt and the copper salt is mixed with the polymer.
US Pat. No. 10,508,191

FLAME-RETARDANT POLYCARBONATE RESIN COMPOSITION, SHEET AND FILM EACH USING SAME, AND METHOD FOR PRODUCING SAID SHEET OR FILM

MITSUBUSHI GAS CHEMICAL C...

1. A polycarbonate resin composition, which contains 18 to 75% by mass of a polycarbonate resin (A) having a viscosity average molecular weight of 35,000 to 60,000, 5 to 30% by mass of a phosphorus-based flame retardant (B), 18 to 50% by mass of a fibrous or plate-like inorganic filler (C) and 0.1 to 2% by mass of a fluoropolymer (D), which has a melt volume rate of 2.0 to 6.0 cm3/10 min under 300° C. and 1.2 kg.
US Pat. No. 10,508,192

THERMOPLASTIC RESIN COMPOSITION, MOLDED ARTICLE, AND MANUFACTURING METHOD OF MOLDED ARTICLE

CANON KABUSHIKI KAISHA, ...

1. A thermoplastic resin composition comprising:a thermoplastic resin;
a filler; and
polyglyceryl fatty acid ester,
wherein the thermoplastic resin contains a component of formula (I):
—CH2—CH?CH—CH2—  (I),
wherein a fatty acid constructing the polyglyceryl fatty acid ester is an unsaturated fatty acid,
wherein a content of the thermoplastic resin is 40 wt % to 79.5 wt %, a content of the filler is 20 wt % to 50 wt %, and a content of the polyglyceryl fatty acid ester is 0.5 wt % to 12 wt %,
wherein a content of the component of the formula (I) with respect to the entire thermoplastic resin is 2 wt % to 30 wt %, and
wherein the unsaturated fatty acid is a hydroxy fatty acid and/or a condensate of the hydroxy fatty acid.
US Pat. No. 10,507,169

AQUEOUS GEL MASK COMPOSITIONS AND KITS

1. An aqueous gel mask composition, comprising:a plurality of sodium alginates constituting, by weight, between 2.2% to 4.5% of the aqueous gel mask composition; and
water,
wherein:
(a) a first sodium alginate of the plurality of sodium alginates includes a molecular weight greater than a second sodium alginate of the plurality of sodium alginates;
(b) less than 3%, by weight, of the aqueous gel mask composition includes sodium alginates having a molecular weight of at least 300 kDa;
(c) the plurality of sodium alginates includes:
(i) an average ratio of ?-D-mannuronate to ?-L-guluronate (M/G ratio) between 70:30 to 50:50;
(ii) an average molecular weight between 150 kDa to 425 kDa;
(iii) at least 20%, by weight, of the sodium alginates having a molecular weight of at least 250 kDa; and
(iv) a weight ratio of sodium alginates having a molecular weight of 75 kDa or less to sodium alginates having a molecular weight of at least 250 kDa of less than 3:2; and
(d) if the plurality of sodium alginates includes two sodium alginates each having a molecular weight of at least 250 kDa, and the two sodium alginates constitute, by weight, less than 1.25% of the aqueous gel mask composition, then the two sodium alginates include an average molecular weight of less than 375 kDa, and
wherein the aqueous gel mask composition is reactive with an activator to form a continuous film, the activator including a salt comprising a divalent cation.
US Pat. No. 10,508,194

FLAME-RETARDANT POLYOLEFIN RESIN COMPOSITION

ADEKA CORPORATION, Tokyo...

1. A flame-retardant polyolefin resin composition comprising 100 parts by mass of a polypropylene resin, 10 to 60 parts by mass of component (A), 15 to 90 parts by mass of component (B), and 10 to 140 parts by mass of component (C):component (A): melamine pyrophosphate;
component (B): piperazine pyrophosphate: and
component (C): glass fiber;
said composition being free of fluorine-containing anti-drip agents.
US Pat. No. 10,507,171

PEROXIDE-STABLE ORAL CARE COMPOSITIONS

Colgate-Palmolive Company...

1. An oral care composition comprising (i) a peroxide whitening agent comprising a whitening complex of crosslinked polyvinylpyrrolidone complexed with hydrogen peroxide, (ii) sodium acid pyrophosphate (Na2H2P2O7) in an amount of from 0.1 wt % to 3 wt % based on the weight of the composition, and (iii) less than 2 wt % water based on the weight of the composition; and (iii) an ethylene oxide, propylene oxide block co-polymer of average molecular weight greater than 5000 Da, being substantially free of an ethylene oxide, propylene oxide block co-polymer of average molecular weight less than 5000 Da in an amount of from 5 wt % to 12 wt % based on the weight of the composition; and (iv) from 1 to 2 wt % tetrasodium pyrophosphate based on the weight of the composition.
US Pat. No. 10,507,172

HYALURONIC ACID FORMULATION CONTAINING PYRUVATE

ALLERGAN INDUSTRIE, S.A.S...

1. A composition comprising: a hyaluronic acid or a salt thereof and pyruvic acid or a salt thereof, wherein the hyaluronic acid or its salt is crosslinked, the composition is suitable for use as a dermal filler, and the composition is a gel that is stable to heat sterilization, wherein the gel has a ?F of ?2N??F?2N after heat sterilization and a ? Tan ? 1 Hz?0.1 after heat sterilization.
US Pat. No. 10,508,196

RUBBER FORMULATION WITH ENHANCED FLEX FATIGUED RESISTANCE

CONTITECH TECHNO-CHEMIE G...

1. A rubber composition comprising EPDM rubber, natural rubber, high cis-1,4-polybutadiene rubber, and from 5 phr to 30 phr of a butyl ionomer, wherein the EPDM rubber is present at a level within the range of 45 to 55 phr, wherein the high cis-1,4-polybutadiene rubber is present at a level in the range of 10 phr to 20 phr, and wherein the natural rubber is present at a level within the range of 30 to 40 phr.
US Pat. No. 10,507,173

DEODORANT COMPOSITION COMPRISING A MIXTURE OF ALPHA, BETA, AND GAMMA CYCLODEXTRIN

AZIENDE CHIMICHE RIUNITE ...

1. An odor-absorbing composition comprising a mixture of ?-, ?-, and ?-cyclodextrins, wherein the amount of one of said ?-, ?-, and ?-cyclodextrins is equal to or higher than the total amount of the other two cyclodextrins,wherein the weight ratio of the amount of said ?-cyclodextrins to the amount of said ?-, and ?-cyclodextrins ranges from 4:1 to 1:1.
US Pat. No. 10,508,197

THERMOPLASTIC VULCANIZATE COMPOSITIONS

ExxonMobil Chemical Paten...

1. A method for preparing a thermoplastic vulcanizate, the method comprising:dynamically vulcanizing at least a portion of an elastomer component in the presence of a thermoplastic resin and a curing agent so as to form a thermoplastic vulcanizate wherein the elastomer component is at least partially vulcanized and is dispersed in a continuous phase comprising the thermoplastic resin; and
introducing a carbon black masterbatch into the thermoplastic vulcanizate, wherein the carbon black masterbatch comprises carbon black particulates dispersed in a carrier resin comprising a propylene-?-olefin copolymer, the propylene-?-olefin copolymer comprising about 50 wt % to about 99 wt % propylene-derived units and about 1 wt % to about 35 wt % comonomer units derived from one of ethylene and a C4-C10 alpha-olefin, and having a heat of fusion of about 75 J/g or less.
US Pat. No. 10,507,177

ANTI-AGING HAIR TREATMENT

1. An anti-aging treatment shampoo comprising:a. Acetyl Cysteine;
b. Alcohol;
c. Inositol;
d. Lactose;
e. Citric acid;
f. Milk Protein (Lactis Proteinum);
g. Panthenyl Ethyl Ether;
h. Serenoa;
i. Sodium Citrate;
j. Glycine soja (soybean) Germ Extract;
k. Biotinoyl Tripeptide;
l. Oleanolic Acid;
m. Butylene Glycol;
n. PEG-40 Hydrogenated Castor Oil;
o. PPG-26-Buteth-26;
p. Arginine
q. Lactic Acid
r. Propanediol
s. Scutellaria baicalensis Root Extract;
t. Acetyl Methione
u. Triticum vulgare (wheat) Germ Extract;
v. Beeswax;
w. Behenyl Alcohol
x. Butyrospermum parkii (Shea Butter) Extract
y. Ethylhexylglycerin
z. Hydroxyethyl Behenamidopropyl Dimonium Chloride
aa. Phenoxyethanol
bb. Pyrus malus Extract;
cc. Caprylhydroxamic Acid
dd. Caprylyl Glycol
ee. Glycerin;
ff. Cetyl Betaine;
gg. Citrullus colocynthis Fruit Extract
hh. Pisum sativum (Pea) Peptide;
ii. Cocamidopropyl Betaine
jj. Sodium Cocoyl Isethionate
kk. Sodium;
ll. Cuscuta reflexa (Giant Dodder) Extract;
mm. Eclipta alba Extract;
nn. Hydrolyzed Quinoa;
oo. Hydrolyzed Rice Protein;
pp. Serrulata Fruit Extract;
qq. Polyquatemium 7;
rr. Purified Water;
ss. Apigenin;
tt. Sodium Lauroyl Methyl Isethionate by weight;
uu. Stearamidopropyl Dimethylamine;
vv. Leuconostoc/Radish Root Ferment Filtrate;
ww. Cannabidiol (CBD);
xx. Calendula officinalis Flower Extract;
yy. Citrus aurantium bergamia (Bergamot) Fruit Extract;
zz. Citrus grandis (Grapefruit) Fruit Extract;
aaa. Citrus (Limon) Peel Extract
bbb. Juniperus Virginia Wood Extract;
ccc. Santalum album (Sandalwood) Wood Extract; and
ddd. Vanilla planifolia Fruit Extract.
US Pat. No. 10,507,178

METHOD FOR TREATING INTERVERTEBRAL DISC DEGENERATION

Research Foundation of th...

1. A method for providing therapeutic benefit to a patient experiencing soft tissue damage between a first bone and a second bone, the method comprising:injecting a composition of matter between the first bone and the second bone of a patient, the composition of matter comprising methacrylated carboxymethylcellulose (CMC), methacrylated methylcellulose (MC), and a polymerization initiator, wherein the patient has a body temperature of at least 33° C.;
permitting the composition of matter to undergo thermal polymerization at the body temperature of the patient, thereby forming a hydrogel between the first bone and the second bone;
wherein the methacrylated methylcellulose (MC) is a mix of a first methacrylated methylcellulose with a first molecular weight below about 20 kDa and a second methacrylated methylcellulose with a second molecular weight above about 30 kDa, the mix being at least 3% (w/v) concentration and less than 8% (w/v) concentration, the first methacrylated methylcellulose and the second methacrylated methylcellulose being in about a 1:1 (w/w) ratio;
wherein the methacrylated carboxymethylcellulose (CMC) has a molecular weight between about 80 kDa and about 100 kDa and is at least 3% (w/v) and less than 8% (w/v) concentration;
wherein the methacrylated methylcellulose (MC) and the methacrylated carboxymethylcellulose (CMC) are present in a 1:1 (w/w) ratio.
US Pat. No. 10,507,179

FORMULATIONS OF LEVOSIMENDAN FOR INTRAVENOUS ADMINISTRATION AS INFUSION OR INJECTION AND OF INFUSION CONCENTRATE

CARINOPHARM GMBH, Elze (...

1. A pharmaceutical composition, comprising Levosimendan as active ingredient, and sulfo-butyl-ether beta-cyclodextrin as a solubilizer, with the proviso that the use of co-solvents comprised of ethanol, propyleneglycol, polyethyleneglycol, poloxamers or polyvinylpyrrolidon is excluded.
US Pat. No. 10,511,021

NON-AQUEOUS ELECTROLYTE SECONDARY BATTERY

SANYO Electric Co., Ltd.,...

1. A nonaqueous electrolyte secondary battery comprising a positive electrode, a negative electrode, and a nonaqueous electrolyte,wherein the positive electrode contains a lithium transition metal oxide, having a layered structure, containing at least Ni and also contains a tungsten compound and/or a molybdenum compound;
the percentage of Ni is greater than 90.00 mole percent with respect to the sum of the molar amounts of metal elements, excluding lithium, in the lithium transition metal oxide;
the amount of the tungsten compound and/or the molybdenum compound is 0.1 mole percent to 1.5 mole percent with respect to the sum of the molar amounts of the metal elements, excluding lithium, in the lithium transition metal oxide in terms of tungsten element and/or molybdenum element; and
wherein the lithium transition metal oxide is represented by the formula LiaNixM1-xO2 (where 0.95?a?1.20, 0.94?x, and M is at least one element selected from Co, Mn, and Al),
wherein the nonaqueous electrolyte contains a lithium salt containing a P—O bond in its molecule and a nitrile compound.
US Pat. No. 10,507,188

PARTICLES CONTAINING AN OPIOID RECEPTOR ANTAGONIST AND METHODS OF USE

The University of Chicago...

1. An enterically-coated particle comprising at least one opioid receptor antagonist, at least one hydrophilic additive that is negatively charged at acidic and neutral pH that is pentasodium tripolyphosphate (TPP), and at least one hydrophilic additive that is positively charged at acidic and neutral pH that is chitosan;wherein the enteric coating comprises a methacrylic acid-methyl methacrylate copolymer.
US Pat. No. 10,509,237

METHOD AND APPARATUS FOR MEASURING ADD POWER OF A CONTACT LENS

CooperVision Internationa...

1. A method of measuring the add power of a contact lens having a central region and an annular region surrounding the central region, the central region having a first optical power and the annular region having a second optical power, the method including the steps:(a) measuring the wavefront aberration of the contact lens;
(b) fitting a polynomial to the measured wavefront aberration, wherein terms of the polynomial correspond to types of aberration comprising defocus and astigmatism and residual aberrations; and
(c) calculating the add power as a defocus corresponding to the residual aberrations,
wherein calculating the add power includes the steps of discarding from the polynomial the terms of the polynomial that correspond to defocus and astigmatism to obtain a modified polynomial that contains only terms of higher aberration order than defocus and astigmatism and calculating the residual aberrations using the modified polynomial; and
the add power is calculated as the spherical equivalent of the residual aberrations or the spherical aberration.
US Pat. No. 10,508,214

COATING COMPOSITION AND COATED METAL PLATE, METAL CONTAINER AND METAL CLOSURE COATED WITH THE COATING COMPOSITION

TOKYO SEIKAN GROUP HOLDIN...

1. A coating composition consisting essentially of a crosslinking agent, a curing catalyst and a mixed polyester resin, the mixed polyester resin consisting essentially of a mixture of a polyester resin (A) and a polyester resin (B) at a weight ratio (A):(B)=98:2 to 50:50,the polyester resin (A) is a polyester resin provided with an acid value resulting from a ring-opening addition reaction of a compound having one or more carboxylic acid anhydride structures in a molecule, and when a total content of carboxylic acid anhydrides to be used for the ring-opening addition reaction is 100 mol %, 10 mol % or more of the carboxylic acid anhydrides are compounds having two or more carboxylic acid anhydride groups in a molecule, wherein the polyester resin (A) has an acid value of 2 to 45 mg KOH/g and a glass transition temperature (Tg) of 35 to 90° C., and the polyester resin (B) has an acid value of 2 to 40 mg KOH/g and a glass transition temperature (Tg) of -20 to 25° C.,
the crosslinking agent is a resol type phenolic resin and/or an amino resin, and is incorporated in an amount of 1 to 30 parts by weight relative to 100 parts by weight of a resin solid content of the mixed polyester resin,
the curing catalyst is incorporated in an amount of 0.1 to 3.0 parts by weight relative to 100 parts by weight of a total resin solids content,
the polyester resin (A) has a number average molecular weight of 8,000 to 21,000,
the polyester resin (B) has a number average molecular weight of 5,000 to 25,000,
the mixed polyester resin has a glass transition temperature (Tgmix) calculated from the following Equation (1) of 40 to 80° C.:
1/Tgmix=Wa/Tga+Wb/Tgb . . .   (1)
where Tgmix represents the glass transition temperature (K) of the mixed polyester resin, Tga represents the glass transition temperature (K) of the polyester resin (A), Tgb represents the glass transition temperature (K) of the polyester resin (B), Wa represents a weight fraction of the polyester resin (A), and Wb represents a weight fraction of the polyester resin (B),
the polyester resin (A) comprises a carboxylic acid component selected from the group consisting of aromatic dicarboxylic acids, aliphatic dicarboxylic acids, unsaturated dicarboxylic acids, alicyclic dicarboxylic acids, trivalent or higher valent carboxylic acids and monocarboxylic acids and an alcohol component selected from the group consisting of aliphatic glycols, ether glycols, alicyclic polyalcohols and trivalent or higher valent polyalcohols,
the polyester resin (B) comprises a carboxylic acid component selected from the group consisting of aromatic dicarboxylic acids, aliphatic dicarboxylic acids, unsaturated dicarboxylic acids, alicyclic dicarboxylic acids, trivalent or higher valent carboxylic acids and monocarboxylic acids and an alcohol component selected from the group consisting of aliphatic glycols, ether glycols, alicyclic polyalcohols and trivalent or higher valent polyalcohols, and
the polyesters (A) and (B) are non-crystalline polyesters.
US Pat. No. 10,508,219

POLISHING COMPOSITION AND METHOD UTILIZING ABRASIVE PARTICLES TREATED WITH AN AMINOSILANE

Cabot Microelectronics Co...

1. A chemical-mechanical polishing composition for polishing a substrate comprising:(i) a liquid carrier,
(ii) an abrasive suspended in the liquid carrier, wherein the abrasive comprises colloidal silica particles having a surface which has been treated with a compound selected from the group consisting of an aminosilane compound, a phosphononiumsilane compound, and a sulfonium silane compound, wherein the particles have a percent surface coverage from about 5% to about 32%, and
(iii) about 0.0001 wt. % to about 3 wt. % of a corrosion inhibitor, wherein the polishing composition has a pH of about 1.5 to about 5.
US Pat. No. 10,508,220

SLURRY COMPOSITION AND ADDITIVES AND METHOD FOR POLISHING ORGANIC POLYMER-BASED OPHTHALMIC SUBSTRATES

Ferro Corporation, Mayfi...

1. An aqueous dispersion for polishing organic polymer-based ophthalmic substrates comprising:5% to about 40% by weight abrasive particles,
0.1-10% by weight of at least one selected from the group consisting of (a) of a polyvinyl alcohol compound, (b) a tertiary amide compound, and (c) combinations thereof,
0.25% to 4.0% by weight aluminum nitrate,
0.5% to about 5% by weight aluminum hydroxide, and deionized water.
US Pat. No. 10,507,197

PHARMACEUTICAL COMPOSITION CONTAINING SILIBININ

Tasly Pharmaceutical Grou...

1. A pharmaceutical composition comprising a mixture of three bulk drugs, wherein the mixture consists of8.75-60 parts by weight of silibinin;
15-65 parts by weight of phospholipid; and
25-200 parts by weight of Pu'er tea extract,wherein parts by weight is the weight ratio of each bulk drug in the mixture.
US Pat. No. 10,507,200

THERAPEUTICS COMPOSITIONS CONTAINING HARMINE AND ISOVANILLIN COMPONENTS, AND METHODS OF USE THEREOF

Ankh Life Sciences Limite...

1. A method of killing or inhibiting the growth of cancer cells selected from the group consisting of lung and lymphoma cells, comprising the step of administering to a patient a composition comprising a quantity of a harmine component selected from the group consisting of harmine, and the esters, metal complexes, and pharmaceutically acceptable salts thereof, with a quantity of a isovanillin component selected from the group consisting of vanillin, isovanillin, and mixtures thereof, and the esters, metal complexes, and pharmaceutically acceptable salts of the foregoing, said composition in a dosage form selected from the group consisting of gels, suspensions, solids, tablets, pills, and capsules, said harmine component and said isovanillin component being selected and present in amounts to provide anti-cancer synergy for the composition.
US Pat. No. 10,507,211

TREATMENT FOR HEREDITARY NEUROPATHY WITH LIABILITY TO PRESSURE PALSIES (HNPP)

Vanderbilt University, N...

1. A method of treating hereditary neuropathy with liability to pressure palsies (HNPP), comprising administering to a subject in need of treatment for HNPP a therapeutically effective amount of a PAK1 inhibitor that is PF-3758309.

US Pat. No. 10,512,169

GLAZING EQUIPPED WITH AN ELECTRICALLY CONDUCTIVE DEVICE POSSESSING AN IMPROVED RESISTANCE TO TEMPERATURE CYCLING TESTS

SAINT-GOBAIN GLASS FRANCE...

1. A glazing consisting of a substrate at least one portion of which comprises an electrically conductive element, said conductive element comprising an electrical connector made of chromium-containing steel, which electrical connector is soldered with a solder based on tin, silver and copper to an electrically conductive track, wherein the electrically conductive track, which is silver-based, has a resistivity measured at 25° C. lower than or equal to 3.5 ??·cm and a porosity level lower than 20%, said porosity level being measured by scanning electron microscopy from a cross section through the portion of the substrate comprising the electrically conductive track and having been polished beforehand by ion milling.

US Pat. No. 10,512,117

COMPUTER PROGRAM, COMPUTER-READABLE STORAGE MEDIUM, FIRST TRANSMISSION POINT AND METHOD PERFORMED THEREIN

Telefonaktiebolaget LM Er...

1. A method performed by a first transmission point for estimating a channel quality gain of a wireless device served by the first transmission point in a wireless communication network, wherein the first transmission point coordinates transmissions with a second transmission point in the wireless communication network, the method comprising:estimating the channel quality gain based on whether a first cell specific reference signal (CRS) configuration of the first transmission point is using radio resources for a first CRS that are colliding or not with radio resources used for a second CRS of a second CRS configuration of the second transmission point in the wireless communication network, and a utilization of frequency resources by the second transmission point, wherein the frequency resources include Physical Resource Blocks (PRBs), and wherein the estimating the channel quality gain comprises using a colliding parameter indicating that the first CRS configuration of the first transmission point is using the radio resources for the first CRS that are colliding or not with the radio resources used for the second CRS of the second CRS configuration of the second transmission point in the wireless communication network, which colliding parameter equals one for a non-shifted case of CRS and is a sum of allocated number of scheduling blocks for all scheduled wireless devices by the second transmission point divided by a total system bandwidth of the second transmission point, for a shifted case of CRS; and
performing link adaptation and scheduling data for the wireless device based on the estimated channel quality gain.

US Pat. No. 10,512,091

DATA COMMUNICATIONS OVER A DISTRIBUTED MULTI-CORE WIRELESS COMMUNICATION NETWORK

Sprint Communications Com...

1. A method of operating a wireless base station in a multi-core data communication network, the method comprising:the wireless base station wirelessly receiving a first Radio Resource Control (RRC) message having a Vehicle-to-X (V2X) service indicator from a first User Equipment (UE) and responsively transferring a first UE message for the first UE to a first network core that serves the first UE with the V2X service responsive to the first UE message;
the wireless base station wirelessly receiving a second RRC message having a text/multimedia messaging service indicator from a second UE and responsively transferring a second UE message for the second UE to a second network core that serves the second UE with the text/multimedia messaging service responsive to the second UE message; and
the wireless base station wirelessly receiving a third RRC message having a video conferencing service indicator from a third UE and responsively transferring a third UE message for the third UE to a third network core that serves the third UE with the video conferencing service responsive to the third UE message.

US Pat. No. 10,512,034

SENSOR PROVISIONING IN WIRELESS SENSOR NETWORKS

BlackBerry Limited, Wate...

1. A method, comprising:determining, at a gateway, that no neighboring gateway is present;
in response to determining that no neighboring gateway is present, starting, by the gateway, a sensor discovery process, wherein the sensor discovery process comprises:
measuring signal strengths from a plurality of sensors;
based on the measured signal strengths, identifying a sensor from the plurality of sensors to be paired with the gateway; and
in response to identifying the sensor, pairing the gateway and the sensor to establish a secured connection between the gateway and the sensor.

US Pat. No. 10,512,020

METHODS AND DEVICES FOR ACCESS NETWORK SELECTION

Telefonaktiebolaget LM Er...

1. A method of selecting an access network for a user equipment, UE, amongst a plurality of access networks, the method comprising the steps of:defining at an Access Network Discovery and Selection Function, ANDSF, server an ANDSF rule to be applied for selection of an access network between a first and a second access network, wherein the ANDSF rule comprises a validity condition to be fulfilled for the ANDSF rule to be applied, wherein the validity condition comprises a validity location area and a validity trajectory towards the validity location area, and wherein the validity trajectory comprises a list with one or more previous location areas;
transmitting the ANDSF rule, which comprises the validity location area and the validity trajectory, from the ANDSF server to an ANDSF client of the UE;
tracking, at the ANDSF client, a historical trajectory for the UE by storing a list with one or more successive location areas where the UE has been located; and
in response to matching a current location of the UE with the validity location area received from the ANDSF server, and matching the historical trajectory tracked at the ANDSF client for the UE with the validity trajectory received from the ANDSF server, determining that the validity condition is fulfilled and applying the ANDSF rule at the ANDSF client.

US Pat. No. 10,512,019

METHOD OF HANDLING RADIO LINK FAILURE IN WIRELESS COMMUNICATION SYSTEM BASED ON MULTI-ENB CONNECTIVITY AND APPARATUS THEREOF

Samsung Electronics Co., ...

1. A method by a terminal in a wireless communication system supporting dual connectivity of a first base station and a second base station, the method comprising:receiving, from the first base station, a configuration message for adding the second base station;
starting a timer upon identifying a predetermined number of consecutive out-of-syncs for a primary secondary cell (pSCell) of the second base station;
detecting a radio link failure (RLF) for the second base station based on an expiration of the timer; and
transmitting, to the first base station, a failure message including a failure type based on detecting the RLF for the second base station.

US Pat. No. 10,512,003

SUBSCRIPTION FALL-BACK IN A RADIO COMMUNICATION NETWORK

TELEFONAKTIEBOLAGET LM ER...

1. A method performed by a card in a radio device, wherein the radio device is performing a fall back step in a communication network from a first subscription to a second subscription, the method comprising steps of:receiving, from the radio device, instructions to change an old International Mobile Subscriber Identity (IMSI) from the first subscription to a new IMSI for the second subscription; and,
sending, to the radio device, a refresh command,
wherein the first subscription is with a first Mobile Network Operator (MNO) and
the second subscription is with a second Mobile Network Operator (MNO).

US Pat. No. 10,511,993

BUFFER STATUS REPORTING AND NEW QUALITY OF SERVICE FLOWS ON DEFAULT BEARER IN NEXT GENERATION RADIO ACCESS NETWORKS

NOKIA TECHNOLOGIES OY, E...

1. A method comprising:triggering transmission of a buffer status report when data, from a new quality of service flow ID that is different from any quality of service flow ID for which data is already available for transmission, arrives in a buffer of a user equipment, wherein the new quality of service flow ID is an identification of a new quality of service flow;
including an indication of the new quality of service flow ID in the buffer status report; and
transmitting the buffer status report to a radio access network, wherein the transmitting of the buffer status report causes the radio access network to relocate the new quality of service flow to another data radio bearer.