US Pat. No. 10,362,985

METHOD AND SYSTEM FOR ANALYZING SKIN LESIONS

STMicroelectronics S.r.l....

1. A method of analyzing digital images of skin lesions, the images including pixels distributed over a lesion area, the method including using at least one processor to process pixels in an analyzed image by:calculating a first set of values indicative of a distribution of the image pixels, wherein the first set of values includes a first discrimination value indicative of a weighted average of the image pixels with weighing at a border of the lesion;
calculating a second set of values indicative of lesion shape, wherein the second set of values includes a second discrimination value indicative of skewness and kurtosis of the distribution of the image pixels;
calculating a third set of values indicative of lesion symmetry, wherein the third set of values includes a third discrimination value indicative of a ratio of symmetry and gray-level power of the distribution of the image pixels;
providing a total additive score of the values in the first, second and third sets of values;
comparing the total additive score with a total score threshold;
comparing the first, second and third discrimination values with respective first, second and third discrimination threshold values; and
providing an output classification for the image analyzed as a function of results of comparing the total additive score with the total score threshold and comparing the first, second and third discrimination values with respective first, second and third discrimination threshold values.

US Pat. No. 10,362,982

SPINAL IMPLANT SYSTEM AND METHOD

Warsaw Orthopedic, Inc., ...

1. A spinal implant system comprising:a link including a first surface and a second surface connectable with a spinal construct, the spinal construct being attachable with one or more vertebral levels, the link extending between a first end and an opposite second end, the second end being integrally formed with the first end, the first end and the second end each comprising an attachment mechanism configured to matingly engage the spinal construct;
a plurality of electrodes including at least one electrode disposed with the first surface and at least one electrode disposed with the second surface, the electrodes being configured to conduct an electric current to stimulate tissue growth adjacent the spinal construct; and
a spinal implant,
wherein the link is configured to act as a power hub to the spinal implant to allow the spinal implant to apply electrical stimulation.

US Pat. No. 10,362,975

SYSTEM AND METHOD FOR FACTORY CALIBRATION OR REDUCED CALIBRATION OF AN INDWELLING SENSOR BASED ON SENSITIVITY PROFILE AND BASELINE MODEL OF SENSORS

DexCom, Inc., San Diego,...

1. A method of calibrating an analyte concentration sensor, the sensor as a member of a manufactured lot of sensors, the lot of a given type of sensor, in which one or more operating parameters of the type of sensor of the lot have been determined, the determining of the operating parameters based on retrospective data, the operating parameters corresponding to at least a sensitivity of the sensor, the operating parameters representing in vivo values, the method comprising steps of:measuring one or more long term drift characteristics of sensitivity of a subset of sensors in the lot;
for a subject sensor, measuring a value of an initial measurable parameter;
correlating the measured value of the initial measurable parameter of the subject sensor to the measured one or more long term drift characteristics via a first set of coefficients;
correlating at least a subset of the one or more determined operating parameters to the measured value of the initial measurable parameter via a second set of coefficients; and
using the first and second set of coefficients to determine an estimated value of at least an in vivo final sensitivity of the subject sensor prospectively, wherein given a measured value of the initial measurable parameter of the subject sensor, an in vivo sensitivity value for the subject sensor can be estimated.

US Pat. No. 10,362,972

METHOD AND SYSTEM FOR PROVIDING AN INTEGRATED ANALYTE SENSOR INSERTION DEVICE AND DATA PROCESSING UNIT

ABBOTT DIABETES CARE INC....

1. A method, comprising:piercing a body of a subject with a sharp distal end of an introducer, the introducer having a portion disposed within a housing;
positioning a first portion of an analyte sensor in the body of the subject, wherein the first portion of the analyte sensor is at least partially disposed within the introducer prior to positioning the first portion of the analyte sensor, and wherein the analyte sensor includes a second portion coupled in electrical contact with a data processing unit disposed within the housing prior to positioning the first portion of the analyte sensor; and
removing the introducer from the housing after positioning the first portion of the analyte sensor such that the first portion of the analyte sensor remains positioned in the body of the subject.

US Pat. No. 10,362,970

PHASE-TO-AMPLITUDE/SLOPE MAPPING

KONINKLIJKE PHILIPS N.V, ...

1. A system, comprising:a processor configured to:
identify a set of motion signal timestamps, for a plurality of motion cycles in a continuous cyclical motion signal indicative of cyclic motion of a moving object, based on a predetermined motion phase of interest and a phase-to-amplitude/slope mapping, wherein the set of motion signal timestamps correspond to a common signal amplitude, wherein each descending amplitude region and each ascending amplitude region of the continuous cyclical motion signal is mapped using a lesser of a mean maximum and a local maximum, and a greater of a mean minimum and a local minimum, and divided for at least one of the local maximum less than the mean maximum or the local minimum greater than the mean minimum; and
generate volumetric image data based on data acquired by a scanner and the identified set of motion signal timestamps.

US Pat. No. 10,362,968

BIOIMPEDANCE CIRCUMFERENCE MEASUREMENT

FRESENIUS MEDICAL CARE HO...

1. An apparatus for measuring the circumference of a limb of an individual comprising:two or more magnetic strips, each of which, during use of the apparatus, surrounds the limb and each of which, along its length, comprises magnetic coding of length information;
a magnetic read head for each magnetic strip for reading the magnetic coding of length information from the strip;
at least two current-injecting electrodes for injecting current at a plurality of frequencies, and at least two voltage-measuring electrodes for measuring resulting voltage between the at least two current-injecting electrodes;
at least one of a pre-amplifier and a low pass filter for processing a signal received from the at least two voltage-measuring electrodes;
an A/D converter for converting the signal from the at least one of the pre-amplifier and the low-pass filter;
a digital signal processing unit for calculating at least one of impedance, resistance, and reactance at the plurality of the frequencies of injected current based on the converted signal received from the A/D converter, wherein the digital signal processing unit is configured to receive a single circumference measurement determined from a plurality of circumference measurements received from the magnetic strips;
a tensioning assembly for setting the tension of the two or more magnetic strips; and
a tension sensor for each magnetic strip;
wherein the apparatus is configured to measure the circumference of the limb in a plurality of cross-sectional areas simultaneously for determining the plurality of circumference measurements.

US Pat. No. 10,362,964

METHOD, APPARATUS, AND SYSTEM FOR PROVIDING MEDICAL IMAGE

SAMSUNG ELECTRONICS CO., ...

1. A method of providing a medical image by using a medical imaging apparatus, the method comprising:determining a start point and a target point in the medical image;
acquiring blood vessel information comprising a diameter and an angle of a blood vessel, which is included in the medical image, from the start point; and
displaying the medical image and a traveling path from the start point to the target point based on the blood vessel information,
wherein
the acquiring of the blood vessel information comprises:
acquiring first blood vessel information of the blood vessel in a region of interest (ROI) with respect to a first position in the medical image;
if there is a point in which a plurality of blood vessels including the blood vessel meet each other in the ROI with respect to the first position, determining whether the point is a bifurcation point or a crossover point based on pixel values of a plurality of points near the point or diameters of the plurality of blood vessels at the plurality of points;
if the point is the bifurcation point, moving a position of the ROI in each direction along bifurcated blood vessels according to the first blood vessel information;
if the point is the crossover point, moving a position of the ROI in a direction along the blood vessel according to the first blood vessel information;
acquiring second blood vessel information of the blood vessel in the ROI with respect to a second position which is moved from the first position; and
determining the traveling path based on a moving path of the ROI.

US Pat. No. 10,362,956

SYSTEM AND METHOD FOR ROTOR DETECTION IN CARDIAC FIBRILLATION

1. A method of detecting a rotor at a location of a heart that experiences cardiac fibrillation, where the method comprises:obtaining, by a processor, an electrogram (EGM) dataset, where the EGM dataset was recorded using a circular bipolar electrode array positioned at the location of the heart, the circular bipolar electrode array having a plurality of bipolar electrodes for simultaneously recording a plurality of bipolar EGMs for the EGM dataset for a recording duration;
detecting, by the processor, a dominant periodicity Cycle Length (CL) and identifying periodic activations for each bipolar EGM associated with the dominant periodicity CL;
tracking, by the processor, the identified periodic activations across each bipolar EGM to define rotational activations and determining when a path taken by the tracked rotational activations corresponds to a rotational activation pattern of a rotor;
detecting, by the processor, the rotor when a number and completeness of the tracked rotational activations meet predefined rotor criteria including that the tracked rotational activations are greater than at least two complete rotations around the circular bipolar electrode array and the completeness of the tracked rotational activations occurs when a time interval spanned by the rotational activations span across the bipolar EGMs with a time duration where a proportion of the time duration relative to the dominant periodicity CL associated with the rotor is greater than a periodic activation duration threshold.

US Pat. No. 10,362,954

HIGH DENSITY ELECTRODE MAPPING CATHETER

ST. JUDE MEDICAL, CARDIOL...

1. A flexible catheter tip, comprising:an inboard understructure that defines a tip longitudinal axis, wherein the inboard understructure is formed from a first continuous element that includes a first rectangular cross-section; and
an outboard understructure that extends along the tip longitudinal axis, wherein the outboard understructure is formed from a second continuous element that includes a second rectangular cross-section, wherein:
the inboard understructure includes a first proximal inboard mounting arm and second proximal inboard mounting arm that extend generally parallel to the tip longitudinal axis;
the outboard understructure includes a first proximal outboard mounting arm and a second proximal outboard mounting arm that extend generally parallel to the tip longitudinal axis;
opposing faces of the first proximal inboard mounting arm and the first proximal outboard mounting arm include a first set of frame locks; and
opposing faces of the second proximal inboard mounting arm and the second proximal outboard mounting arm include a second set of frame locks corresponding to the first set of frame locks, wherein the first set of frame locks and the second set of frame locks are configured to interlock with one another.

US Pat. No. 10,362,953

ELECTRODE ARRAY CATHETER WITH INTERCONNECTED FRAMEWORK

Biosense Webster (Israel)...

1. A catheter comprising:an elongated catheter body having a proximal end, a distal end; and
an electrode array assembly having a plurality of electrodes, a proximal end and a distal end mounted at the distal end of the catheter body and comprising an interconnected framework having a plurality of elements interconnected by a plurality of junctions at locations intermediate the proximal and distal ends of the electrode array assembly, the interconnected framework comprising a polymeric layer and a plurality of printed electrodes positioned on all connected elements of at least some of the junctions, wherein the interconnected framework has a collapsed configuration in which the elements are arranged generally along a longitudinal axis of the catheter body and an expanded configuration in which the elements are positioned radially outwards from the longitudinal axis to deploy the array of electrodes mounted on the interconnected framework.

US Pat. No. 10,362,952

STABILIZED SPINE ELECTROPHYSIOLOGIC CATHETER

BIOSENSE WEBSTER (ISRAEL)...

1. A catheter comprising:an elongated catheter body having a proximal end, a distal end; and
a stabilized spine electrode assembly mounted at the distal end of the catheter body and comprising at least two spines and at least two tethers, each spine having at least one electrode and a proximal end attached at the distal end of the catheter body, wherein the at least two tethers are secured to one location on one spine and to a plurality of locations on an adjacent spine and are secured between locations distal of the proximal ends of adjacent spines and wherein each spine has a collapsed arrangement in which the spines are arranged generally along a longitudinal axis of the catheter body and an expanded arrangement in which at least a portion of each spine bows radially outwards from the longitudinal axis and the at least two tethers exert tension on the adjacent spines, the stabilized spine electrode assembly being further configured to move from a first expanded configuration to a second expanded configuration when in the expanded arrangement.

US Pat. No. 10,362,941

METHOD AND APPARATUS FOR PERFORMING REGISTRATION OF MEDICAL IMAGES

Samsung Electronics Co., ...

1. A method of performing registration of medical images, comprising:mapping, by a processor, a virtual coordinate system used by a first medical apparatus and a virtual coordinate system used by a second medical apparatus to each other, wherein a real-time medical image is captured in a first position of a patient by the first medical apparatus and a three-dimensional (3D) medical image is previously captured in a second position of the patient by the second medical apparatus;
detecting, by the processor, a position of a probe of the first medical apparatus in the virtual coordinate system used by the second medical apparatus, based on a result of the mapping;
determining, by the processor, a volume image, corresponding to the detected position of the probe, from the previously captured 3D medical image;
selecting a reference cross-section from the determined volume image using the detected position of the probe;
estimating a relative movement range of a scanning plane of the probe from the reference cross-section according to a patient's physical movement with the probe being static relative to the virtual coordinate system used by the second medical apparatus and by using previously stored information about a range in which an organ can be moved by the patient's physical movement;
selecting neighboring cross-sections that exist in the estimated relative movement range of the scanning plane;
reconstructing a volume image by accumulating the reference cross-section and the neighboring cross-sections; and
extracting, by the processor, from the reconstructed volume image a cross-sectional image corresponding to the real-time medical image, wherein the cross-sectional image changes according to the patient's physical movement, and
wherein the determined volume image comprises a volume image smaller than the previously captured 3D medical image and has a dimension determined by the estimated relative movement range of the scanning plane of the probe from the reference cross-section.

US Pat. No. 10,362,935

USER INTERFACE FOR EFFICIENTLY DISPLAYING RELEVANT OCT IMAGING DATA

CARL ZEISS MEDITEC, INC.,...

1. A method of automatically aligning a depth range for obtaining a volume cube scan of a retina of an eye using an optical coherence tomography (OCT) system, said method comprising:acquiring two or more B-scans using the OCT system at a first set of system alignment conditions;
performing image processing on the two or more B-scans to determine a location where the retina would appear in the volume cube scan if the volume cube scan was acquired at the first set of system alignment conditions;
adjusting the system alignment conditions to optimize placement of the retina within the scan volume;
acquiring an OCT volume cube scan at the optimized system alignment conditions; and
storing or displaying the OCT volume cube scan or storing or displaying a further analysis thereof.

US Pat. No. 10,362,931

OPTICAL DEVICE

PANASONIC INTELLECTUAL PR...

1. An optical device, comprising:an excitation light source that emits excitation light;
a first optical fiber that guides the excitation light emitted from the excitation light source; and
a wavelength-conversion plate that includes: a wavelength converter that receives the excitation light guided by the first optical fiber and emits wavelength-converted light; and a reflective film on a side of the wavelength converter that receives the excitation light,
wherein the reflective film is spaced from a light exit surface of the first optical fiber, transmits the excitation light, and reflects the wavelength-converted light.

US Pat. No. 10,362,920

SURFACE CLEANING MACHINE

1. A surface cleaning machine, comprising:a cleaning roller holder;
at least one cleaning roller which is arranged on the cleaning roller holder;
a drive device for driving the at least one cleaning roller in rotation; and
a sweeping element which is associated with the at least one cleaning roller and which feeds swept material to the at least one cleaning roller;
wherein the sweeping element, at least during a cleaning operation, is in contact with a surface to be cleaned and projects with a front region into a jacket of the at least one cleaning roller; and
wherein a front face end of the sweeping element is arranged on the front region.

US Pat. No. 10,362,917

CLEANING ROBOT

SAMSUNG ELECTRONICS CO., ...

1. A cleaning robot comprising a main body and a drive unit to move the main body, further comprising:an input unit to input a motion instruction for the cleaning robot;
a tilt sensor to measure an inclination of the cleaning robot moving in accordance with the input motion instruction; and
a controller to determine a stuck state of the cleaning robot by using an angle value obtained by measuring an angle the cleaning robot has moved based on sensor information of the tilt sensor.

US Pat. No. 10,362,916

AUTONOMOUS CLEANER

LG ELECTRONICS INC., Seo...

1. An autonomous cleaner comprising:a cleaner body including a plurality of wheels and a controller that manages driving of at least one of the wheels;
a dust container dock recessed in the cleaner body and being opened at a rear end of the cleaner body;
a dust container removable from the dust container dock, the dust container having a portion protruding beyond the rear end of the cleaner body when the dust container is set into the dust container dock; and
a dust container cover hinged to the cleaner body and configured to cover the dust container,
wherein when the dust container cover is closed onto the dust container, which is set into the dust container dock, a portion of the dust container cover protrudes beyond the rear end of the cleaner body, and
wherein the dust container cover includes:
a top cover that is at least partially transparent;
a bottom cover coupled to the top cover to form, together with the top cover, an appearance of the dust container cover; and
a plurality of infrared receivers provided in an internal space provided between the top cover and the bottom cover and spaced apart from each other.

US Pat. No. 10,362,914

CLEANER AND CONTROL METHOD THEREOF

SAMSUNG ELECTRONICS CO., ...

11. A cleaner comprising:a power supply;
a suction unit including a main suction port;
a driving unit including a motor including a rotor and a stator;
a sensing unit including a hall sensor to detect a position of the rotor; and
a controller configured to control the power supply to supply predetermined rotor rearrangement power, which is power supplied for rearrangement of the position of the rotor, to the motor for a predetermined time period until cogging torque of the motor reaches a maximum, ending the supply of the predetermined rotor rearrangement power to the motor when the cogging torque of the motor reaches the maximum, supply start-up power to the motor according to the position of the rotor detected by the hall sensor, and supply stopping power to the motor after the cogging torque of the motor reaches the maximum,
wherein the stopping power is supplied in an opposite direction to that of the rotor rearrangement power, or the stopping power is a zero voltage, and
wherein the rotor rearrangement power is supplied such that torque that is generated by the rotor rearrangement power is greater than cogging torque of the motor.

US Pat. No. 10,362,912

VACUUM CLEANER

LG ELECTRONICS INC., Seo...

1. A vacuum cleaner comprising:a cleaner body; and
a dust collector received in the cleaner body, wherein the dust collector includes:
an external case having a first dust storage space therein;
an upper cover installed to cover an upper opening of the external case;
a lower cover coupled to a lower opening of the external case;
a first cyclone installed within the external case, having a mesh filter to filter first contaminants from air sucked from outside the dust collector, and configured to introduce the filtered air inside the first cyclone;
a second cyclone provided in the first cyclone and configured to separate second contaminants from the filtered air introduced inside of the first cyclone;
one or more cleaning extensions configured to remove a portion of the first contaminants clinging on an outer circumferential surface of the mesh filter; and
a rotary case coupled to the mesh filter and relatively rotating the mesh filter with respect to the cleaning extensions.

US Pat. No. 10,362,908

WEIGHTED TOWEL WITH HANDLES

1. A towel for drying a person having an extremity and a lap comprising a rectangle-shaped flexible absorbent material comprising a top end, a bottom end, a left side, a right side and a center portion;wherein two weights are inserted into pockets positioned at the bottom end;
wherein the weights comprise non-magnetized material;
wherein the top end and the center portion are both un-weighted;
wherein located in the center portion of the towel is at least one loop handle;
wherein the at least one loop handle is located in one position;
wherein there are no opposing handles; and
wherein the un-weighted top end acts as a covering for the lap and the weighted bottom end of the towel wraps around the extremity.

US Pat. No. 10,362,907

SOLID SOAP HOLDER

1. A soap holder comprising an elastic wristband, the wristband having a face having a first side and a second side, the first side of the face having an indentation for receiving a piece of solid soap, a plurality of prongs being provided inside the indentation for penetrating and retaining a piece of soap pressed into the indentation, the wristband being reversible so that either one of the first side or the second side faces outwards.

US Pat. No. 10,362,905

WHISK AND DIGITAL THERMOMETER

1. A whisk and digital thermometer comprising:a handle, a plurality of wire loops and a temperature probe;
wherein the whisk and digital thermometer is able to stir food that is cooking in a pot and simultaneously monitor and report a temperature of the food;
wherein the handle is adapted to provide a grasping surface that allows a cook to carry and manipulate the whisk and digital thermometer;
wherein the handle provides a housing for a circuit board of electronics that measure and report the temperature;
wherein the handle comprises a handle body and a cap;
wherein a top of the handle body is open to accept the cap;
wherein the top of the handle body provides a threaded interior interface for coupling with the cap;
wherein a bottom of the handle body is closed except for a central hole for passage of the temperature probe and except for a plurality of holes that accept ends of the plurality of wire loops;
wherein the cap is an enclosed cylinder that houses the electronics and one or more batteries;
wherein the top surface of the cap comprises an operator control panel;
wherein the bottom surface of the cap comprises a threaded interface that couples to the handle body;
wherein the temperature probe is coupled to the bottom of the cap and extends downwards from the center of the cap;
wherein the plurality of wire loops comprise the whisk portion of the whisk and digital thermometer;
wherein an individual loop selected from the plurality of wire loops is a straight piece of wire that has been bent into a horseshoe shape;
wherein the loose ends of the individual loop are inserted into the bottom of the handle body;
wherein each of the plurality of wire loops extend into the handle body by a different distance so that the bent portion of the individual loops pass each other without interference at the bottom of the whisk and digital thermometer;
wherein the temperature probe comprises a metal shaft located at the longitudinal center of the whisk and digital thermometer;
wherein the temperature probe couples to the circuit board located within the cap and runs through the center of the handle, emerging from the bottom of the handle and running towards the bottom of the whisk and digital thermometer;
wherein the temperature probe stops before reaching the plurality of wire loops at the bottom of the whisk and digital thermometer;
wherein the temperature probe comprises a temperature sensor which is located at the bottom of the temperature probe and which is coupled to the circuit board via wiring.

US Pat. No. 10,362,902

HAND-SHIELD FOR COOKWARE AND KITCHEN UTENSILS

1. A hand-shield for protecting a user's hand from flying hot liquid droplets and from convective and/or radiative heat while cooking in a basket having opposed wire-mesh side walls, opposed wire-mesh front and rear walls, a wire-mesh bottom, and an open top, the shield comprising a single-piece or a multiple-piece curved or flat plate of material configured to permanently or detachably attach to an edge or a wall of the basket and form a protective wall on a path of a droplet of splashing fluid, flying towards the user's hand.

US Pat. No. 10,362,901

AIR-BASED FRYER PAN

KONINKLIJKE PHILIPS N.V.,...

1. A pan for a hot air apparatus for preparing food, comprising:a pan bottom providing a pan surface area for receiving food to be prepared;
side-walls at least partly surrounding the pan surface area;
a mounting connector for mounting the pan inside a food preparation chamber of an apparatus for preparing food; and
an air movement device configured to create an air flow that is vertically oriented downward streaming in outer circumferential portions of the food preparation chamber and is vertically oriented upward streaming though the pan;
wherein the air movement device is arranged to extend perpendicular and to a side of the pan or the air movement device is arranged to extend parallel and during use, is oriented above the pan;
wherein the pan bottom is provided with a plurality of through-holes as a hot air passage;
wherein the through-holes cover approximately 3 to 50% of the pan surface area; and
wherein a heat capacity per area of a bottom surface of the pan bottom is between 10 and 75 JK?1 dm?2.

US Pat. No. 10,362,900

TOASTER

1. A toaster with a housing, in which housing there is provided a first cavity for toasting bread and a second cavity outside of and separate from the first cavity, a baffle plate being provided between and separating the first cavity and the second cavity, the housing having at least one slot for receiving bread into the first cavity, wherein the first cavity is provided with heating elements adapted to toast bread in use, the toaster being provided with control circuitry for the heating elements that includes a thermal fuse,wherein there is a first saturation temperature range for toasting bread in the at least one slot, wherein the first saturation temperature range, in normal use, does not increase significantly with time after a period of continuous use of the toaster, and wherein a graph of recorded temperature against time during the first saturation temperature range shows a saw tooth pattern,
wherein there is a second saturation temperature range, which second saturation temperature range corresponds to a runaway condition,
wherein there is a difference in temperature in the second cavity between the first saturation temperature range and the second saturation temperature range,
wherein the thermal fuse is positioned in the second cavity, and
wherein the thermal fuse has an actuation temperature between the first saturation temperature range and the second saturation temperature range, as measured in the second cavity.

US Pat. No. 10,362,897

CONTROL CIRCUIT FOR SELF-TURN-OFF OF AN AUTOMATIC MACHINE

1. An automatic coffee machine having a control circuit for self-turn-off and a brewing water circulation pump, the automatic coffee machine being connectable to a domestic voltage power line and comprising:a logic controller having a low supply electric voltage;
a power supply of the logic controller;
at least one control switch to control at least the brewing water circulation pump, said at least one control switch being connected to the logic controller, and being activatable by a manual activation button of the automatic coffee machine;
an electrically actuated deviator connected to the logic controller and switchable between:
a machine activation status, where the electronically actuated deviator connects a main electric power line of the power supply of the logic controller to the domestic voltage power line, where at least the brewing water circulation pump is operated by the at least one control switch, and
a machine deactivation status, where the electrically actuated deviator connects a secondary electric power line of the power supply of the logic controller to the domestic voltage power line, said secondary electric power line having a reactivation switch, separate from the at least one control switch, activatable by a manual reactivation button of the automatic coffee machine, separate from the manual activation button, the reactivation switch being normally open when the automatic coffee machine is turned on, the reactivation switch being connected to the logic controller,
where, in the machine deactivation status, the control circuit, the brewing water circulation pump, the logic controller, and the power supply for the logic controller, of the automatic coffee machine are disconnected from the domestic voltage power line when the reactivation switch is open, whether the manual activation switch is open or closed, and where the manual reactivation button of the automatic coffee machine is activatable to turn the automatic coffee machine on and off; and
at least one condenser to maintain the power supply of the logic controller for an entire operating time of a switching of the electrically actuated deviator from the machine deactivation status of the machine activation status, said switching of the electrically actuated deviator being automatically generated by closure of the reactivation switch.

US Pat. No. 10,362,895

DEVICE TO PRODUCE MILK-BASED DRINKS WITH A CONNECTION SYSTEM AND A COFFEE MAKER CONTAINING SUCH A DEVICE

SEB S.A., Ecully (FR)

1. A milk-based drink production device designed to work with a steam output nozzle tip of a coffee maker, the milk-based drink production device comprising a steam input conduit and a connection system comprising at least one mobile jaw and fixed jaw in which the connection system is connected to the steam output nozzle tip wherein the at least one mobile jaw alternates between a connected position in which a watertight connection is formed between the steam output nozzle tip and the steam input conduit and in which the milk-based drink production device cannot be separated from the steam output nozzle tip, and a disconnected position in which the milk-based drink production device may be separated from the steam output nozzle tip,wherein the mobile jaw is formed from a receptacle having an upper opening and a lateral conduit that extends from the receptacle to the steam input conduit,
wherein the steam output nozzle tip is inserted into the upper opening of the receptacle of the mobile jaw to connect the connection system to the coffee maker and, when making the connection to the coffee maker, the mobile jaw moves vertically against the fixed jaw that is positioned above the mobile jaw in a cover of the milk-based drink production device, and
wherein the mobile jaw contains at least two trunnions, and the connection system further comprises a transfer piece that is mounted to rotate on the cover and which comprises at least two parallel, lateral partitions and at least two housings that match the trunnions formed on the mobile jaw.

US Pat. No. 10,362,894

GLOBALLY NETWORKED ON-DEMAND COFFEE BLENDING AND BREWING SYSTEM

1. An apparatus, comprising:a plurality of coffee varietal hoppers;
a brew chamber configured to brew measured amounts of one or more coffee varietals;
a transport system between the plurality of coffee varietal hoppers and the brew chamber configured to transport the measured amounts of one or more coffee varietals according to a coffee blend formula from the plurality of coffee varietal hoppers to the brew chamber;
a weight-based measurer configured to transfer a measured amount of coffee varietal material from the plurality of coffee varietal hoppers to the transport system;
a water supply configured to provide water to the brew chamber;
a processor configured to execute one or more processes to determine the coffee blend formula; and
a memory configured to store a process executable by the processor, the process when executed operable to:
receive a requested coffee blend formula having an associated flavor profile;
in response to the requested coffee blend formula being possible with the plurality of coffee varietals available, blend and brew one or more of the plurality of coffee varietals according to the requested coffee blend formula; and
in response to the requested coffee blend formula not being possible with the plurality of coffee varietals available:
determine a translated coffee blend formula from the plurality of coffee varietals available based on the associated flavor profile of the requested coffee blend formula; and
blend and brew one or more of the plurality of coffee varietals according to the translated coffee blend formula.

US Pat. No. 10,362,893

CAPSULE HOLDER FOR A BEVERAGE PREPARATION MACHINE

Nestec S.A., Vevey (CH)

1. A capsule holder for holding a closed capsule in a beverage preparation machine, the capsule containing a beverage precursor ingredient, the beverage preparation machine being able to inject a fluid under pressure through a top membrane of the capsule to an inside of the capsule such that the fluid and the precursor ingredient mix to make a beverage, the capsule holder comprising:a cup-shaped body adapted to retain and hold the capsule, the cup-shaped body comprises a dispensing hole through a bottom wall of the capsule holder opposite from and co-axial with an opening in the capsule holder through which the capsule is inserted into the capsule holder;
a rotationally movable handle;
a guide member for removably inserting the capsule holder within the beverage preparation machine; and
a pressure-releasing member for releasing fluid pressure inside the capsule, the pressure-releasing member comprising a piercer adapted to pierce at least one channel through a sidewall of the capsule, the piercer comprising a pin element movably linked to the rotationally movable handle through a cam element attached to or integrally formed with the rotationally movable handle, such that the pin element is slidable substantially perpendicular relative to a capsule sidewall surface when a rotation movement is applied to the rotationally movable handle, and the pin element movable through a first internal surface of the cup-shaped body between (i) a retracted position wherein the pin element does not protrude from the first internal surface of the cup-shaped body of the capsule holder and (ii) an extended position wherein the pin element protrudes from the first internal surface of the cup-shaped body to be able to perforate the at least one channel through the sidewall of the capsule, the pin element is perpendicular to the first internal surface, the cup-shaped body further comprises a second internal surface that together with the first internal surface defines part of a compartment in the cup-shaped body that receives the capsule, the dispensing hole opens into the compartment through the second internal surface, the first internal surface is located below a top of the capsule holder, the first internal surface is adjacent to the sidewall of the capsule in the retracted position and the extended position of the pin element, and the second internal surface is adjacent to a bottom end of the capsule in the retracted position and the extended position of the pin element.

US Pat. No. 10,362,888

POSTURE IMPROVEMENT PILLOW

1. A pillow comprising:(a) a body having a top surface, a flat bottom surface, a left upper region, a left central region, a right upper region, a right central region, a left leg, a right leg, and a main vertical end wall that connects to said top surface at a top edge and connects to said bottom surface at a bottom edge;
(b) said symmetrically shaped body having six contoured cutouts formed from said main vertical end wall connecting said left upper region, said left central region, said right upper region, said right central region, said left leg, and said right leg;
(c) said left leg and said right leg formed from said main vertical end wall transitioning from a thickness T1 to a thickness T2;
(d) a U-shaped first contoured cutout between said left leg and said right leg;
(e) a second contoured cutout between said right leg and said right central region, said right leg perpendicular to said right central region;
(f) a third contoured cutout between said right central region and said right upper region;
(g) a U-shaped fourth contoured cutout between said right upper region said left upper region;
(h) a fifth contoured cutout between said left upper region and said left central region;
(i) a sixth contoured cutout between said left central region and said left leg perpendicular to said left central region;
(j) said top surface having a centrally located pocket with said centrally located pocket sized to receive a temperature pack;
(k) said body is symmetrically shaped around a central axis;
(l) said bottom edge extends a perimeter of said pillow; and
(m) said third contoured cutout has a shape that is a mirror image opposite to the shape of said fifth contoured cutout and said second contoured cutout has a shape that is a mirror image opposite to the shape of said sixth contoured cutout;
(n) wherein each contoured cutout is sized and shaped to support a user's neck.

US Pat. No. 10,362,886

SMALL ITEM OVERSTOCK STORAGE SYSTEM

WALMART APOLLO, LLC, Ben...

6. A gondola storage system comprising:a vertical plane of a gondola shelf system;
a horizontal shelf connected to the vertical plane; and
a tiered shelf attachment made of wire, the tiered shelf attachment removeably attached to the horizontal shelf, the tiered shelf attachment comprising:
a support structure having gondola shelf connectors located at each corner of a base of the support structure, the gondola shelf connectors configured to removeably attach the support structure to the horizontal shelf by passing through a gondola shelf connector hole and a hole of the horizontal shelf, the respective gondola shelf connector hole being aligned with the hole of the horizontal shelf;
two or more tiers mounted on the support structure, each tier including a horizontal segment and a vertical segment, the horizontal segment being substantially perpendicular to the vertical segment, each tier in the two or more tiers having an identical width between tiers;
a side support piece which connects the two or more tiers to the support structure;
a plurality of dividers removeably attached to the horizontal segment of each tier in the two or more tiers, each divider in the plurality of dividers held in place by tabs which extend under the horizontal segment of the tier in which the divider is located.

US Pat. No. 10,362,885

DEVICES AND METHODS TO PROTECT NEONATES DURING BED-SHARING AND CO-SLEEPING

1. A frame for a protective enclosure to protect a neonate during bed-sharing and co-sleeping, comprising:a frame base portion sized to accommodate a neonate and adapted to rest upon a sleeping surface;
a roll-over bar attached to said frame base portion, wherein said roll-over bar is arched above the sleeping surface, wherein said frame base and roll-over bar includes one or more hinges, pivots, or rotational elements, configured so as to elevate said frame base portion above said sleeping surface when a force or pressure is applied by a co-sleeper to said roll-over bar, and to permit placement or removal of said neonate from underneath the protective enclosure.

US Pat. No. 10,362,874

SEATING DEVICE

HERMAN MILLER, INC., Zee...

1. A seating device comprising:a base;
a seat post extending from the base, the seat post having a first end adjacent the base, a second end opposite the first end, and a longitudinal axis extending between the first end and the second end;
a seat supported by the seat post above the base; and
a multiple-link rocking assembly coupled between the base and the first end of the seat post and operable to angularly displace the seat post relative to the base only forwardly and rearwardly relative to the base.

US Pat. No. 10,362,873

CHILD SAFETY ANTI-TIPOVER PROTECTION DEVICE

1. A child safety anti-tipover protection device, comprising:a. a first bracket extending between first and second ends and having first and second sides;
b. a second bracket hingedly connected to said first side of said first bracket at an intermediate position between said first and second ends, and having first and second sides;
c. a first strip of fastener material disposed on said second side of said first bracket, said first strip of fastener material extending between said first and second ends and crossing said intermediate position; and
d. a second strip of fastener material disposed on said first surface of said second bracket;
e. wherein said second bracket rotates around a fixed axis;
f. wherein said fixed axis is parallel to said first side of said first bracket.

US Pat. No. 10,362,870

UNIVERSAL DRAWER SLIDE

1. A drawer slide, comprising:an outer slide member and an inner slide member configured to move between a closed position and an extended position;
a lever is pivotally mounted to a front portion of the inner slide member;
a cam configured to mount to the outer slide member in a first position and a second position;
the lever includes an engaging end that engages with the cam to secure the inner slide member to the outer slide member; and,
wherein the lever moves in a first direction to engage the cam in the first position, and the lever moves in a second direction to engage the cam in the second position.

US Pat. No. 10,362,869

DRAWER ARRANGEMENT

Julius Blum GmbH, Hoechs...

1. A drawer arrangement, comprising:a drawer side wall, the drawer side wall having a support portion for supporting a drawer bottom; and
a drawer pull-out guide having a carcass rail to be fixed to a furniture carcass, a drawer rail connected to the drawer side wall, and a central rail displaceable between the carcass rail and the drawer rail, the central rail having a side limb and a transverse limb connected therewith;
wherein at least a portion of the side limb of the central rail is arranged laterally besides the support portion,
wherein the transverse limb of the central rail and the carcass rail protrude at least partially below the support portion, and
wherein the transverse limb of the central rail has a free end region supported on the carcass rail by at least one rolling body.

US Pat. No. 10,362,868

COMPACT BROOM AND DUST MOP STORAGE RACK

1. A compact dust mop and broom storage rack comprising:two symmetrical parallel vertical end panels, facing one another enclosing three horizontal panels of equal length, the three horizontal panels include
an upper horizontal panel having a flat back side, and a perpendicular rail facing a front along the length of the upper horizontal panel, the perpendicular rail of the upper horizontal panel having a plurality of semi-circular notches spaced equal distance apart along the perpendicular rail, and bounded by one of the symmetrical vertical end panels at one end of the upper horizontal panel length, and the other symmetrical vertical end panel at the opposite end of the upper horizontal panel length;
a middle horizontal panel having a flat front side, and a perpendicular rail facing a back along the length of the middle horizontal panel, the perpendicular rail of the middle horizontal panel having a plurality of semi-circular notches spaced equal distance apart along the perpendicular rail, where each semi-circular notch on the perpendicular rail of the middle horizontal panel has an open end facing an opposite direction of a corresponding semi-circular notch on the perpendicular rail of the upper horizontal panel, and the middle horizontal panel is bounded by one of the symmetrical vertical end panels at one end of the middle horizontal panel length, and the other symmetrical vertical end panel at the opposite end of the middle horizontal panel length;
a lower horizontal panel that is sloped downwards toward the front of the compact dust mop and broom storage rack, and bounded by one of the symmetrical vertical end panels at one end of the lower panel length, and the other symmetrical vertical end panel at the opposite end of the lower horizontal panel length.

US Pat. No. 10,362,867

PILLOW RACK

1. A foldable rack for storing pillows comprising:(a) a first frame member and a second frame member, the first and second frame members each being generally planar and defined by a first end, a second end, and opposite lateral sides connecting the first end and the second end, the first and second frame members having an upper portion and a lower portion defined by a central axis;
(b) a plurality of rods extending between the first end and the second end of the first and second frame members;
(c) a plurality of hubs, each hub of the plurality of hubs being disposed on an associated rod of the plurality of rods at the central axis of both the first and second frame members, each hub having an axial bore formed therethrough, the axial bores being in registry with each other, wherein the hubs of the first and second frame members abut one another and form a stable substantially continuous sleeve with a substantially continuous bore; and
(d) an elongated pin extending through the axial bores of each hub thereby rotatably joining the first frame member to the second frame member at the central axis.

US Pat. No. 10,362,864

CONVERTIBLE LED TABLE TRAY

1. A convertible LED table tray, comprising:a central compartment, wherein the central compartment further comprises a upper deck;
a drawer movable relatively in and out the central compartment;
a first side compartment connected to the central compartment;
a second side compartment opposed to the first side compartment connected to the central compartment;
at least one light-emitting diode light on the upper deck;
a charger plate;
a means for holding the charger plate on the upper deck of the central compartment; and
a means for joining the first side compartment and the second side compartment with the central compartment, and wherein the first side compartment and the second side compartment are detachable from the central compartment.

US Pat. No. 10,362,863

STOWABLE SENSORY LEARNING ASSEMBLY

1. A stowable sensory learning assembly, comprising:a horizontal base having a bottom surface and a top surface;
a vertical housing having a bottom end and a top end, the bottom end connected to the top surface of the horizontal base;
a system controller positioned on the vertical housing, the system controller configured to automatically control the stowable sensory learning assembly;
a canopy housing in communication with the system controller, the canopy housing configured to provide sensory stimulation, the canopy housing having a bottom end, a top end, and first and second sides extending between the top end and the bottom end defining a plane, the top end of the canopy housing pivotably coupled to the vertical housing at a first distance above the horizontal base;
a display housing in communication with the system controller, the display housing configured to provide sensory stimulation, the display housing having a bottom end, a top end, and first and second sides extending between the top end and the bottom end defining a display screen configured to provide sensory stimulation, the top end of the display housing pivotably coupled to the bottom end of the canopy housing, wherein the display screen is configured to provide a visual indication of progress towards completion of a task, wherein a green light indicates the beginning of the task, a yellow light indicates the task is coming to an end and a red light indicates completion of the task;
a desk housing in communication with the system controller, the desk housing configured to provide sensory stimulation, the desk housing having a bottom end, a top end, and first and second sides extending between the top end and the bottom end defining a writing surface configured to provide sensory stimulation, the top end of the desk housing pivotably coupled to the bottom end of the display housing;
wherein the display housing and the desk housing are automatically movable via the system controller relative to the canopy housing between a stowed position where the desk housing and display housing are substantially parallel to the canopy housing, and a deployed position where the display housing and the desk housing are angled relative to one another to define a work space;
an automated reward dispenser in communication with the system controller, the automated reward dispenser connected to the vertical housing at a second distance above the horizontal base, wherein the automated reward dispenser is configured to automatically provides a reward concurrently with completion of the task displayed on the display screen; and
a remote computer configured for remotely controlling the system controller via a wireless network.

US Pat. No. 10,362,861

LEG LATCHING DEVICE FOR A TABLE, AND A TABLE INCORPORATING SAME

Varidesk, LLC, Coppell, ...

1. A table, comprising:a table top;
a bracket secured to the table top;
a latching device coupled to the bracket, the latching device having a retaining wedge coupled to a draw latch via a cam device and a shaft; and
a table leg,
wherein the draw latch is configured to pivot with respect to a cam follower of the cam device to laterally move the shaft and the retaining wedge connected thereto between a first position securing the table leg to the bracket and a second position unsecuring the table leg from the bracket.

US Pat. No. 10,362,857

DEVICE FOR REMOVING OBJECT ON ROAD SURFACE, GUIDE RAIL TYPE VEHICLE, AND METHOD FOR REMOVING OBJECT ON ROAD SURFACE

MITSUBISHI HEAVY INDUSTRI...

1. A device for removing an object on a road surface, the device comprising:a brush section which is provided between an end portion in an advancing direction of a vehicle body of a guide rail type vehicle that travels on the road surface, and a traveling wheel provided below the vehicle body, wherein
the brush section comprises a brush body in which a plurality of linear members are bundled, and
a lower end of the brush body is positioned closer to the end portion of the vehicle body than an upper end of the brush body at a use position in which the lower end of the brush body is configured to come into contact with the road surface.

US Pat. No. 10,362,854

BOTTLE, RETAINING DEVICE AND ASSOCIATED ELEMENTS FOR CARRYING CONTAINERS AND OTHER ITEMS

Amphipod, Inc., Seattle,...

1. A bottle and retaining clip, comprising;a bottle having a bottom, a mouth, and sidewalls extending from the bottom to the mouth, the sidewalls comprising a first sidewall and an opposing second sidewall, and a third sidewall and an opposing fourth sidewall, the third and fourth sidewalls joining the first and second sidewalls, the first and second sidewalls each being wider than each of the third and fourth sidewalls, the third sidewall having a first shoulder and the fourth sidewall having a second shoulder;
a retaining clip comprising a base configured for removable attachment to a support member, the clip having:
(1) a first arm extending from the base and an opposing second arm extending from the base;
(2) a third arm extending from the base and an opposing fourth arm extending from the base;
(3) the first and the third arms engaging the first shoulder when the bottle is attached to the retaining clip; and
(4) the second and the fourth arms engaging the second shoulder when the bottle is attached to the retaining clip;
the base of the clip having a first elongated slot extending between the first arm and the second arm, the first elongated slot being formed by:
a first projection formed in the base and extending from a position adjacent a juncture of the first arm and the base; and
a second projection formed in the base and extending from a position adjacent a juncture of the second arm and the base;
the first projection extending toward the second projection and defining an opening between the first projection and the second projection to provide access to the first elongated slot;
the base of the clip having a second elongated slot extending between the third arm and the fourth arm, the second elongated slot being formed by:
a third projection formed in the base and extending from a position adjacent a juncture of the third arm and the base; and
a fourth projection formed in the base and extending from a position adjacent a juncture of the fourth arm and the base;
the third projection extending toward the fourth projection and defining an opening between the third projection and the fourth projection to provide access to the second elongated slot;
the bottle further having a central axis extending from the base of the bottle to the mouth;
the base being removably attachable to the support member via the first and second slots;
whereby the bottle is configured for mating engagement with the clip and further wherein at least one of the bottle and the clip is configured and formed from a material that is sufficiently flexible to readily release the bottle from the retaining clip.

US Pat. No. 10,362,851

SQUEEZABLE NAIL TREATMENT CONTAINER

1. An apparatus for providing nail or skin treatment, comprising:a container, formed of a compressible material;
an insert, disposed within the container formed of a compressible material, and configured to receive and surround at least one body part of a user; and
an opening at a first end of the container which provides access to an interior surface of the insert,
wherein the insert is configured to hold at least one substance configured to treat at least one of a nail and skin of the user,
wherein the insert is made of spongy material, and further includes:
an inner sponge; and
an outer sponge, wherein the inner sponge is disposed within the outer sponge, and an interface between an outer surface of the inner sponge and an inner surface of the outer sponge is configured to receive multiple fingers of the user simultaneously and allow movement of the multiple fingers along the interface,
the apparatus further comprising a lid assembly configured to connect to the container and cover the opening, and to hold a detail sponge that is disposed within the insert when the lid assembly is connected to the container,
the lid assembly further including an outer cap configured to be opened, without being disconnected from the container, to expose an inner cover which secures the detail sponge to the lid assembly, such that removal of the inner cover removes the detail sponge from the lid assembly and exposes a second opening which allows access to the insert and has a smaller width than the opening of the container.

US Pat. No. 10,362,849

LICE AND NIT REMOVAL TOOL AND METHOD

1. A method of removing lice nits from a person's hair, the method comprising:grasping a first fabric sheet having a plurality of projections on a first face of the first fabric sheet;
folding the first fabric sheet around a first lock of the person's hair such that the first face of the first fabric sheet contacts the first lock of the person's hair;
squeezing the first fabric sheet while folded around the first lock of the person's hair;
moving the first fabric sheet lengthwise along the first lock of the person's hair while squeezing the first fabric sheet around the first lock of the person's hair;
disposing of the first fabric sheet;
grasping a second fabric sheet having a plurality of projections on a first face of the second fabric sheet;
folding the second fabric sheet around a second lock of the person's hair such that the first face of the second fabric sheet contacts the second lock of the person's hair;
squeezing the second fabric sheet while folded around the second lock of the person's hair;
moving the second fabric sheet lengthwise along the second lock of the person's hair while squeezing the second fabric sheet around the second lock of the person's hair;
disposing of the second fabric sheet; and
inserting a first digit of the user's hand into a first pocket defined on a second face of the first fabric sheet prior to squeezing the first fabric sheet around the first lock of the person's hair, the first pocket located adjacent a first end of the first fabric sheet.

US Pat. No. 10,362,848

UNIVERSAL NO-SLIP HAIRPIN

1. A universal asymmetric hairpin, comprising:at least two legs of different length;
an interface configured to attach replaceable charms;
a layer of no-slip coating applied over the legs; and
at least two replaceable tips attached to ends of the legs,
wherein the ends of the legs comprise screws for screwing into the replaceable tips.

US Pat. No. 10,362,846

PROTECTIVE CASE WITH OVER-CENTER FLAP CLOSURE AND STYLUS HOLDER

1. A case for a device and a stylus comprising:a sleeve portion having a sleeve opening;
a stylus cavity located within the sleeve portion, the stylus cavity having a stylus cavity opening adjacent the sleeve opening;
a closure portion; and
a hinge connecting the closure portion to the sleeve portion adjacent the sleeve opening and the stylus cavity opening, the hinge adapted to allow the closure portion to move between a first position away from the sleeve opening and stylus cavity opening to allow the device to be inserted into the sleeve portion and the stylus to be inserted into the stylus cavity, and a second position where the closure portion is positioned over the sleeve opening and stylus cavity opening;
wherein the closure portion comprises:
a closure-portion front side configured to cover a portion of a front side of the device when arranged in the case with the closure being in the second position;
a closure-portion rear side configured to cover a portion of a rear side of the device when arranged in the case with the closure being in the second position;
a closure-portion top side that connects a top end of the closure-portion front side with a top end of the closure-portion rear side, and which is configured to cover a portion of a top side of the device when arranged in the case with the closure being in the second position;
a closure-portion left side that connects a left end of the closure-portion front side with a left end of the closure-portion rear side, and which is configured to cover a portion of a left side of the device when arranged in the case with the closure being in the second position; and
a closure-portion right side that connects a right end of the closure-portion front side with a right end of the closure-portion rear side, and which is configured to cover a portion of a right side of the device when arranged in the case with the closure being in the second position.

US Pat. No. 10,362,845

THREE COMPONENT BINDER CLIP FOR USE IN PERSONAL ACCESSORY DESIGNS

1. A binder clip comprised of:a. a first and a second wire arm, identical to one another and each having two ends, and, each bent into a planar U-shape, the planar U-shape, having three closed sides formed from the wire arms and, and a fourth, open side, of the planar U-shape, including the two ends of the wire arms bent towards one another forming two wire tabs pointing towards one another leaving a gap between the wire tabs, and,
b. a metal spring formed from an essentially rectangular sheet of metal having first and second edges, each parallel to one another, and, third and fourth edges, each parallel to one another and perpendicular to the first and second edges, and, the metal spring formed by bending the third and fourth edges of the rectangular sheet of metal towards each other to form a U-shaped spring, and, the first and second edges rolled to form a first and a second cylinder, each cylinder having two ends and an opening at each of the ends, and, the openings having an edge, and,
c. the two wire tabs of the first wire arm are inserted into the two ends of the first cylinder, one per end, and the two wire tabs of the second wire arm are inserted into the two ends of the second cylinder, one per end, and,
d. a flexible cover that fits over the planar U-shape of the first and second wire arms and the flat metal spring, and,
e. when the U-shapes of each of the two wire arms are moved apart, the flexible cover contacts the U-shaped spring and acts as a fulcrum, pressing against the U-shaped spring to pry open the U-shaped metal spring, separating the first and second cylinders for insertion of an item to be held in the clip that, when the U-shapes of the arms are released, the item is then held in place between the rolled edges.

US Pat. No. 10,362,843

GEMSTONE AND METHOD FOR CUTTING THE SAME

1. A circular-cut gemstone comprising:a girdle having a top edge and a lower edge;
a crown extending from the girdle's top edge at a crown angle less than 23 degrees so that a substantial portion of light entering one side of the crown exits an opposite side of the crown; and
a pavilion extending downward from the girdle's bottom edge and having a pavilion angle the same as an ideal-cut-diamond.

US Pat. No. 10,362,842

VARIABLE MAGNETIC CONFIGURATION FOR JEWELRY

1. A jewelry article having a first configuration with an associated first wearable length and a second configuration with an associated second wearable length, the second wearable length being different than the first wearable length, said article comprising:a first chain and a second chain, each of the first chain and the second chain having two ends, a plurality of non-magnetizable links, a first end portion, a middle portion, and a second end portion, a plurality of magnetizable links, and a plurality of magnets, the plurality of magnets and the plurality of magnetizable links being interspersed within each of the first chain and the second chain so as to allow a user to selectively attach at least one of the plurality of magnets to at least one of the plurality of magnetizable links to change the jewelry article from the first configuration to the second configuration,
wherein the first chain comprises three magnetizable links of the plurality of magnetizable links (1, 2, 3) being interspersed on the first end portion of the first chain, two magnetizable links of the plurality of magnetizable links (5, 6) being interspersed on the second end portion of the first chain, two magnetizable links of the plurality of the magnetizable links (4, 7) being interspersed on the middle portion of the first chain, and a first and a second magnet of the plurality of magnets (C, D) being interspersed on the middle portion of the first chain,
wherein the second chain comprises three magnetizable links of the plurality of magnetizable links (8, 9, 10) being interspersed on the first end portion of the second chain, four magnetizable links of the plurality of magnetizable links (11, 12, 13, 14) being interspersed on the second end portion of the second chain, and a first and a second magnet of the plurality of magnets (A, B) being interspersed on the middle portion of the second chain; and
a clasp configured to releasably secure the two ends of the first chain relative to the two ends of the second chain,
wherein the first configuration is a necklace, and wherein none of the plurality of magnets selectively attaches to another of the plurality of magnets or to the plurality of magnetizable links, and
wherein the second configuration is a peter pan necklace, wherein the first magnet on the second chain selectively attaches to one of the magnetizable links on the first end portion of the first chain or to one of the magnetizable links on the first end portion of the second chain, and the second magnet on the first chain selectively attaches to one of the magnetizable links on the second end portion of the first chain or to one of the magnetizable links on the second end portion of the second chain.

US Pat. No. 10,362,839

SLIDE FASTENER

YKK Corporation, (JP)

17. A fastening device comprising:a first tape portion; and
a first fastening portion joined to the first tape portion, the first fastening portion defining a first side surface and a second side surface opposite from the first side surface, the first fastening portion comprising a plurality of fastening elements extending from the first side surface, the plurality of fastening elements arranged lengthwise along a lengthwise direction of the fastening device, each adjacent pair of fastening elements offset by a pitch distance and defining a fastening gap therebetween, each of the plurality of fastening elements comprising an engagement portion extending in a direction parallel to the lengthwise direction of the fastening device, the second side surface of the first fastening portion defining a plurality of relief grooves, the fastening device being a first fastening device, the first fastening device configured to be joined to a second fastening device comprising a second fastening portion having the same geometry as the first fastening portion of the first fastening device.

US Pat. No. 10,362,838

HOOK AND EYE FASTENER

1. A hook and eye fastener for securing two pieces of a garment together, the fastener comprising:a hook part configured to be mounted on a face of one of the pieces of the garment, the hook part comprising a substantially planar body configured to lay flat on the face of the piece of the garment, and an arm extending outwardly from the body, the arm comprising an inner portion connected to the body at a first end, the inner portion extending outwardly substantially perpendicular to the body, and an outer portion connected to a second end of the inner portion, the outer portion extending substantially parallel to the planar body, and a side of the outer portion facing towards the planar body defining a hook part abutment surface;
an eye part configured to be mounted on a face of the other one of the pieces of the garment, the eye part comprising a substantially planar frame configured to lay flat on the face of the other of the pieces of the garment, the frame defining an open mouth with a circumferential lip, the open mouth dimensioned to receive the outer portion of the arm of the hook part, and having an eye part abutment surface on an underside of the frame, the eye part abutment surface shaped complementary to the hook part abutment surface for engagement therewith;
when the body of the hook part and the frame of the eye part are touching or closely juxtaposed, the eye part is slidably engageable with the hook part to bring the hook part abutment surface and the eye part abutment surface into engagement with each other and fasten the two pieces of the garment together when the hook part is mounted on one of the pieces and the eye part is mounted on the other one of the pieces; and,
wherein the open mouth of the eye part comprises a slot formed in the lip along a leading edge thereof, and the hook part comprises a divider wall located on an underside of the arm for engagement in the slot formed in the lip of the eye part, the divider wall extending downwardly and substantially perpendicular from the hook part abutment surface of the outer portion of the arm and forwardly and substantially perpendicular from a front surface of the inner portion of the arm.

US Pat. No. 10,362,835

STROBEL LASTED INJECTED FOOTWEAR

Fuerst Group, Inc., Menl...

1. A footwear article comprising:a footwear-structure bag encompassing an injected filler material, the footwear-structure bag forming an integrated footwear component, where the injected filler material is an injected foam;
a strobel sock of the footwear-structure bag that is made of a first material, the strobel sock forming an insole region of the footwear-structure bag, where the strobel sock is coupled to a second material of the footwear-structure bag by a stitched junction at the insole region that directly attaches the first material of the strobel sock to the second material of the footwear-structure bag, where the first material of the strobel sock is a highly stretchable material, and where the second material of the footwear-structure bag is a minimally stretching material that is different than the first material of the strobel sock; and
an outsole directly coupled to the footwear-structure bag forming a base of the footwear article,
wherein the stitched junction is a stitch and turn seam including stitches, and wherein the stitches are located within an interior of the footwear-structure bag, encompassed by the injected foam.

US Pat. No. 10,362,830

PAIN REDUCING FOOTWEAR AND SYSTEMS AND METHODS FOR USING SAME

1. A system for reducing pain, the system comprising:an article of footwear comprising an upper connected to a sole;
at least one vibration device disposed within the upper, the at least one vibration device comprising: a casing comprising an application area, and at least one vibrational element contained within the casing, the at least one vibrational element configured to deliver vibrations directly to a surface on a top portion of a foot of a user of the footwear; wherein the casing comprises interior walls defining interior sections sized and shaped to contain the at least one vibrational element; wherein substantially all of the vibrational energy emitted from the at least one vibrational element is transmitted through the application area of the casing directly to the user's foot; and wherein the at least one vibration device is not disposed within or positioned on the sole;
a controller communicatively connected to the at least one vibration device and configured to control operation of the at least one vibration device based on instructions regarding operation of the at least one vibration device; and
a control unit communicatively connected to the controller and configured to transmit instructions regarding the operation of the at least one vibration device to the controller;
wherein the casing is manufactured from a pliant material comprising at least one of: natural or synthetic woven or non-woven fabrics, rubbers, polymer materials, and silicone-based materials; and
wherein there is an absence of open space between the interior casing walls and the at least one vibrational element.

US Pat. No. 10,362,829

MULTI-LAYER HELMET AND METHOD FOR MAKING THE SAME

Bell Sports, Inc., Scott...

1. A protective helmet to be worn by a wearer while participating in a motor sports or power sports activity, the helmet comprising:a one-piece outer shell; and
a multi-layer liner assembly disposed within the one-piece outer shell and sized for receiving a wearer's head, the multi-layer liner assembly including an inner-layer, a middle-layer, and an outer-layer, said multi-layer liner assembly permits relative rotational movement between said layers where said movement results from an impact to the helmet while the helmet is being worn by the wearer:
the inner-layer comprising an inner surface oriented towards an inner area of the helmet, wherein the inner-layer comprises an energy management material that has a thickness that is (i) greater than a thickness of the middle-layer and (ii) less than a thickness of the outer-layer, and said inner-layer having: (i) a hardness that is greater than a hardness of the middle-layer and less than a hardness of the outer-layer and (ii) a plurality of channels, each channel extending upward from a lowermost edge of the inner-layer and being formed completely through the inner-layer whereby the inner-layer is segmented;
the middle-layer disposed adjacent an outer surface of the inner-layer, wherein the middle-layer comprises an energy management material that has a thickness that is less than both the inner-layer and the outer-layer, said middle-layer has a plurality of channels, each channel extending upward from a lowermost edge of the middle-layer and being formed completely through the middle-layer whereby the middle-layer is segmented; and
the outer-layer disposed adjacent an outer surface of the middle-layer, the outer-layer comprising an outer surface oriented towards the one-piece outer shell, wherein the outer-layer comprises an energy management material that has a thickness that both: (i) varies between a front region of the outer-layer and a crown region of the outer-layer and (ii) is greater than both the inner-layer and the middle-layer.

US Pat. No. 10,362,825

ROTATABLE BRIM CAP WITH STABILIZED TRACK TRANSITION INTERFACE

1. A cap with a rotatable brim comprising a crown having a substantially circular circumferential lower edge to fit on a wearer's head and having an inner surface along said lower edge; a brim having an arcuate edge attached to said crown and extending substantially outwardly away from said crown; an elongate track extending along said circumferential lower edge attached to said inner surface and having opposing free ends or edges when formed along a generally circular path; an elongate slide having a length substantially equal to said arcuate edge and connected to said brim along said arcuate edge, said track and slide forming interlocking means for allowing movements of said elongate slide only along the entire length of said elongate track; first alignment means for aligning said opposing edges when brought into abutment to form a substantially continuous track with an interface parting line; and second alignment means extending across at least a portion of said interface parting line to prevent relative movements of said opposing edges about said first alignment means, whereby said first and second alignment means fix and stabilize said opposing free ends or edges at said interface parting line to maintain alignment and eliminate discontinuities of said opposing edges in said elongate track to insure smooth movements of said brim independently of the position of said brim along said elongate track.

US Pat. No. 10,362,824

ANGLED ARRAY OF AIRFLOW CHANNELS

1. An apparatus comprising:a head covering configured to be worn on a head of a wearer; and
a bill attached to the head covering, wherein the bill has a transversal curvature, the bill comprising an angled-array of air flow channels with a varying geometry relative to a mediator of the transversal curvature that is configured to enable air that is flowing from a direction in front or to the side of the head covering to enter into the channels from a bottom of the bill at a first angle relative to a longitudinal axis of the bill and be deflected upward so that the air continues traveling inside the channels through the bill at a second angle relative to the longitudinal axis of the bill until the air exits from the channels at a top of the bill, wherein each of the air flow channels is arranged at a fixed angle relative to the bill to prevent direct light, which is shining onto the top of the bill at a perpendicular angle relative to the bill, from passing through the bill and shining onto the wearer.

US Pat. No. 10,362,820

COLD WEATHER VENTED GARMENT

NIKE, Inc., Beaverton, O...

1. A method of making a garment comprising:aligning a first panel of material with a second panel of material, wherein the first panel of material and the second panel of material are shaped to form a back section of the garment, wherein a superior portion of the back section of the garment is configured to cover an upper portion of a wearer's back that is proximate to a neck of a wearer and wherein an inferior portion of the back section of the garment is configured to cover a lower portion of the wearer's back proximate to a waist of the wearer, when the garment is in an as worn configuration;
affixing the first panel of material and the second panel of material together at a first plurality of seams located in the superior portion of the back section and a second plurality of seams located in the inferior portion of the back section to form one or more chambers defined by the first panel of material, the second panel of material, and at least one seam in the first plurality of seams located in the superior portion of the back section of the garment, and at least one seam in the second plurality of seams located in the inferior portion of the back section of the garment;
perforating one or more of the first plurality of seams located in the superior portion of the back section of the garment to create at least one perforation on the one or more of the first plurality of seams located in the superior portion of the back section of the garment, wherein the at least one perforation extends through the one or more of the first plurality of seams, through the first panel of material, and through the second panel of material, and not creating any perforations on the second plurality of seams located in the inferior portion of the back section of the garment;
filling the one or more chambers with one or more of down and synthetic fibers; and
using the back section to form the garment.

US Pat. No. 10,362,819

LOW-PROFILE EDGE POCKET

NIKE, Inc., Beaverton, O...

1. An article comprising:a trim piece having a first layer and a second layer;
a panel comprising at least a first edge, the panel having an incised opening proximate to the first edge, wherein the first edge of the panel is secured between the first and second layers of the trim piece; and
a pocket having a pocket opening in communication with the incised opening of the panel and positioned directly adjacent to a bottom edge of the trim piece, the pocket opening releasably secured by a zipper comprising at least a first zipper tape and a second zipper tape, the first zipper tape being affixed to the panel and the second zipper tape being affixed between the first and second layers of the trim piece.

US Pat. No. 10,362,813

ATHLETIC BAND WITH REMOVABLE MODULE

NIKE, Inc., Beaverton, O...

1. A band comprising:a tubular body having an inner surface and an outer surface, with the inner surface defining a central passage, wherein the tubular body is configured to be worn on a user's body such that a portion of the user's body is received in the central passage, the tubular body comprising a first layer and a second layer comprising an elastic fabric material; and
a housing formed of a polymer material and connected to the tubular body such that a portion of the housing is received between the first and second layers, wherein the housing has an outer wall and an inner wall, a cavity defined between the outer wall and the inner wall of the housing, and an access opening providing access to the cavity, wherein the housing is configured to removably receive an electronic module in the cavity through the access opening, wherein the polymer material of the housing has greater rigidity than the elastic fabric material, and wherein the housing is positioned such that the access opening is open to the inner surface of the tubular body and accessible for insertion and removal of the electronic module from the inner surface of the tubular body,
wherein the housing further comprises a slot in communication with the cavity, the slot configured to permit passage of moisture away from the housing.

US Pat. No. 10,362,812

FABRIC DEVICE

1. A fabric device comprising:a fabric including a fabric body configured to contact or to be worn on an object, said fabric body having a first surface configured to contact the object, and a second surface opposite to said first surface, said fabric body being internally formed with a passage unit, said passage unit having a plurality of passages arranged in a grid structure and intersecting and communicating with each other; and
an electronic module disposed in said fabric body and including a plurality of electronic components, in the form of strips, extending into said passage unit, and a plurality of conductive pads formed on said first surface of said fabric body;
wherein the object is a human body,
wherein each of said electronic components is a conductive wire, and has a first end extending out of said second surface of said fabric body and a second end opposite to said first end; and
wherein each of said conductive pads is electrically connected to said second end of a corresponding one of said electronic components.

US Pat. No. 10,362,810

GARMENT WITH UNIVERSAL FLY

1. A garment comprising:a first modular portion having a substantially tubular first leg enclosure on a first side from a lowermost end up to a crotch position, a first torso portion contiguous with the first leg enclosure, the first torso portion having first front and back regions proceeding upward from the crotch position to a continuous waist circumference, providing a first waist opening, with the first front and back regions ending at first front and back edges at an angle from the crotch position up to just below the waist height, the first front and back edges forming a first side opening from the torso region above the crotch position; and
a second modular portion essentially a mirror image of the first modular portion, having a substantially tubular second leg enclosure on a second side from a lowermost end up to the crotch position, a second torso portion contiguous with the second leg enclosure, the second torso portion having second front and back regions proceeding upward from the crotch position to a continuous waist circumference, providing a second waist opening, with the second front and back regions ending at second front and back edges at an angle from the crotch position up to just below the waist height, the second front and back edges forming a second side opening from the torso region above the crotch position;
wherein the first modular portion, juxtaposed with the second modular portion by passing the first modular portion down through the second waist opening and the first leg enclosure through the second side opening with the first torso portion inside the second torso portion, aligning the first waist opening inside the second waist opening, provides the garment with leg enclosures for both of a wearer's legs, with a combined torso portion with the second front and back edges of the second side opening exposed, and the first front and back edges of the first side opening covered beneath fabric of the second torso region, enabling the wearer to grasp and pull the exposed second front edge in a first direction toward the first side opening to an extent to expose and grasp a part of the first front edge, and then to pull the first front edge in the opposite direction from the first direction to an extent to then expose a region of the wearers lower torso, and to also enable the wearer to grasp the exposed second back edge and to pull the exposed second back edge toward the first side opening to an extent to expose and grasp a part of the first back edge, and then to pull the first back edge in the opposite direction to an extent to then expose a region of the wearers crotch or buttocks area.

US Pat. No. 10,362,808

E-CIGARETTE PERSONAL VAPORIZER

AYR LTD, London (GB)

1. A re-fillable and re-chargeable inhalable vapor dispensing system including (i) a user-replaceable e-liquid reservoir for dispensing e-liquid and (ii) an e-liquid filling device; in which the reservoir is inserted into, or otherwise attached to, the e-liquid filling device and engages with an electrical or electronic fluid transfer system in the e-liquid filling device, the fluid transfer system being configured to transfer e-liquid from the e-liquid reservoir to a fluid storage chamber configured to supply e-liquid to an atomizing unit;and in which the filling device is lockable to prevent use by unauthorized persons, including under-age persons.

US Pat. No. 10,362,806

ELECTRONIC VAPING DEVICE AND COMPONENTS THEREOF

ALTRIA CLIENT SERVICES LL...

1. An electronic vaping (e-vaping) device comprising:a pre-vapor formulation storage element connectable to a power supply, the pre-vapor formulation storage element configured to contain a pre-vapor formulation material and including a fibrous material, the pre-vapor formulation material being absorbed in the fibrous material, the pre-vapor formulation storage element further including,
an outer casing extending in a longitudinal direction,
an air inlet,
a vapor outlet,
an inner tube within the outer casing defining a central air passage communicating with the air inlet and the vapor outlet, and
a susceptor located adjacent the central air passage, the susceptor being operable to heat the pre-vapor formulation material to a temperature to vaporize the pre-vapor formulation material; and
the power supply including,
an outer casing extending in a longitudinal direction including a power source in electrical communication with an induction source, the induction source being axially spaced from the susceptor by a distance if the power supply is attached to the pre-vapor formulation storage element such that the induction source is operable to generate an inductive field to heat the susceptor if powered by the power source such that the susceptor heats the pre-vapor formulation material to a temperature to vaporize the pre-vapor formulation material.

US Pat. No. 10,362,804

AEROSOL-GENERATING DEVICE WITH SEALED COMPARTMENT

ALTRIA CLIENT SERVICES LL...

1. An aerosol-generating device comprising:a housing defining at least one internal compartment, the housing being waterproof with regard to the at least one internal compartment;
a power supply positioned within the at least one internal compartment;
an electric heater positioned within the at least one internal compartment; and
a haptic feedback device positioned within the at least one internal compartment.

US Pat. No. 10,362,777

INTERNAL BALLASTABLE RODENT BAIT STATION

Bell Laboratories, Inc., ...

1. A bait station which can accommodate an internal ballast weight, the bait station comprising:a base having a floor, and an upwardly extending peripheral wall which extends upwardly from the floor, wherein portions of the peripheral wall define at least one rodent access opening, and wherein portions of the floor extend upwardly from the at least one rodent access opening to form a ramp;
a tray spaced from the floor to define an interior volume between the base floor and the tray which is not accessible to a rodent, wherein the ramp extends from the at least one rodent access opening at least substantially to a height defined by the tray;
wherein the tray is arranged to support bait or a trap on the tray and above the interior volume between the base floor and the tray which is not accessible to a rodent;
wherein the interior volume between the base floor and the tray which is not accessible to a rodent has a volume at least sufficient to contain a weight of at least 7 pounds;
a plurality of tabs arranged along the peripheral wall, the plurality of tabs extending inwardly of the peripheral wall to support the tray spaced from the floor;
a cover having an upper wall and a cover side wall which extends downwardly from the upper wall to engage the peripheral wall, and a plurality of flanges which extend downwardly from the cover side wall to position the tray between the flanges and the tabs; and
a latch arranged between the base and the cover to retain the cover closed over the base.

US Pat. No. 10,362,764

CAT AMUSEMENT SYSTEM

Worldwise, Inc., Novato,...

1. A cat amusement system comprising:a user actuated transmitter sized to be held by hand, said transmitter comprising (1) an actuation signal generator for remotely controlling a pet activity toy and (2) a user actuated light generator for generating light at a wavelength and intensity to be visible to a pet proximate said pet activity toy; and
a pet toy comprising (1) a motor, (2) power source for powering said motor, (3) a receiver for receiving said actuation signal, and (4) an actuator for controlling said motor propelling said pet activity toy upon receipt of said actuation signal emanating from said transmitter,
said actuation signal generator and said user actuated light generator being operable independently of one another for attracting a pet cat to stimulate its hunt and pounce instincts.

US Pat. No. 10,362,763

EXCREMENT-TREATING MATERIAL AND METHOD FOR MANUFACTURING SAME

PEPARLET CO., LTD., Shiz...

1. An excrement-treating material, comprising:a water-absorbing core part; and
a surface layer covering the core part, wherein the surface layer exposes a color of a surface of the core part upon absorption of excreted urine,
wherein the core part is formed by wet-kneading and compression-granulating a compounding material containing a paper powder and organic or inorganic fine pieces as major materials, dents or/and protrusions are formed on the surface of the core part by deformation by the kneading or compression of the fine pieces or peeling-off of the fine pieces from the paper powder upon release of compression, the surface of the core part is discontinuously colored by utilizing the dents or/and the protrusions to form a colored part and a non-colored part, the discontinuously-colored surface of the core part is covered with the surface layer, and the color of the colored part of the surface of the core part is exposed through the surface layer during absorption of the excreted urine, whereas the non-colored part of the surface of the core part is stained by a color of the excreted urine, and the color of the excreted urine is exposed through the surface layer.

US Pat. No. 10,362,740

EMITTER AND DRIP IRRIGATION TUBE

Enplas Corporation, Sait...

1. An emitter configured to be joined to an inner wall surface of a tube for distributing irrigation liquid at a position corresponding to a discharging port that communicates between an interior and an exterior of the tube, the emitter being configured to quantitatively discharge the irrigation liquid in the tube out of the tube from the discharging port, the emitter comprising:a water intake part for intake of the irrigation liquid;
a discharging part disposed to face the discharging port and configured to discharge the irrigation liquid, the discharging part including a discharging, recess;
a first channel configured to connect the water intake part and the discharging recess together, and distribute the irrigation liquid;
a second channel configured to connect the water intake part and the discharging recess together, and distribute the irrigation liquid;
a flow rate reducing part disposed in the first channel and configured to reduce a flow rate of the irrigation liquid in accordance with a pressure of the irrigation liquid in the tube;
a channel opening/closing part disposed in the second channel, and configured to open and close the second channel in accordance with the pressure of the irrigation liquid in the tube;
a pressure reducing channel disposed in the first channel on an upstream side relative to the flow rate reducing part, and configured to reduce a pressure of the irrigation liquid taken from the water intake part and guide the irrigation liquid to the flow rate reducing part; and
a bypass channel disposed in the second channel on an upstream side relative to the channel opening/closing part, and configured to guide the irrigation liquid taken from the water intake part to the channel opening/closing part while maintaining the pressure of the irrigation liquid taken from the water intake part at a pressure higher than a pressure of the irrigation liquid having passed through the pressure reducing channel, wherein:
in response to the pressure of the irrigation liquid flowing through the tube is smaller than a first pressure, the irrigation liquid taken from the water intake part is guided to the discharging recess through the pressure reducing channel and the bypass channel, and
in response to the pressure of the irrigation liquid flowing through the tube is equal to or greater than the first pressure, the second channel is closed with the channel opening/closing part, and the irrigation liquid taken from the water intake part is guided to the discharging recess through the pressure reducing channel.

US Pat. No. 10,362,734

GRAIN YIELD SENSOR FOR AN ARTICULATED AGRICULTURAL HARVESTING COMBINE

Tribine Industries LLC, ...

1. In a grain harvesting articulated combine of a forward crop processing power unit (PPU), a rear grain cart, and an articulation joint that connects the PPU with the rear grain cart, wherein the articulation joint includes a grain auger assembly running from the PPU to the rear grain cart for transferring clean grain from the PPU to the rear grain cart and having a forward grain auger assembly end at the PPU and a grain auger assembly rear end adjacent to the rear grain cart, the grain auger assembly comprises a tube housing a rotating flighted auger therewithin; the improvement which comprises:the rotating flighted auger being terminated with a rotating paddle assembly having paddles and a grain yield sensor being carried by the rear grain cart and being located adjacent to and beside the rotating paddle assembly, wherein the rotating paddle assembly throws grain laterally against the grain yield sensor.

US Pat. No. 10,362,733

AGRICULTURAL HARVESTER CONFIGURED TO CONTROL A BIOMASS HARVESTING RATE BASED UPON SOIL EFFECTS

IOWA STATE UNIVERSITY RES...

1. An agricultural harvester (100) comprising:a control system (166) configured to:
calculate a plurality of biomass return rates as the agricultural harvester traverses an agricultural field, wherein each of the plurality of biomass return rates is iteratively calculated until an estimated soil loss exceeds a soil loss threshold or at least one of estimated soil quality indices fall below a soil quality threshold, wherein each calculation comprises:
starting with a proposed biomass return rate of one hundred percent and calculating the estimated soil quality indices and the estimated soil loss;
for every subsequent iteration, reducing the proposed biomass return rate by a predetermined amount and recalculating the estimated soil quality indices and the estimated soil loss; and
when the estimated soil loss exceeds the soil loss threshold or at least one of the estimated soil quality indices falls below the soil quality threshold, setting the biomass return rate to the proposed biomass return rate of the previous iteration; and
control a biomass harvesting rate based upon the calculated biomass return rate.

US Pat. No. 10,362,730

QUICK CHANGE LAWN MOWER BLADES

MTD Products Inc, Valley...

12. A blade for a lawn maintenance device comprising:a blade having a blade major axis, a second blade axis perpendicular to the blade major axis, and a center axis perpendicular to the blade major axis and the second blade axis;
wherein the blade defines a first aperture that is asymmetric and is centrally located and the first aperture has a first portion and a second portion partially intersecting the first portion, wherein
the first portion has a long dimension, a short dimension and a first centerline along its long dimension,
the second portion has a long dimension, a short dimension and a second centerline along its long dimension, and
the first and second centerlines are generally parallel to each other, but not parallel to the blade major axis or the second blade axis,
the first and second centerlines are offset with respect to each other,
wherein the first portion and the second portion each include an elongated shape having parallel sides, a first end having a first radius, and a second end having a second radius that is greater than the first radius of the first end.

US Pat. No. 10,362,729

MACHINE FOR HARVESTING ROOTS SUCH AS BEETS, HAVING A MEANS FOR AUTOMATIC ADJUSTMENT OF THE HARVESTING UNIT

EXEL INDUSTRIES, Paris (...

1. A machine for harvesting roots planted in the ground and aligned along rows, comprisinga horizontal cutting unit of a head of roots provided with a means for automatically adjusting a level of a cutting blade depending on the level of the head,
a harvesting unit configured to dig the ground beneath the roots at a relative height below the cutting level, including a means for detecting a height of a top of the root, and a means for adjusting the relative height of the harvesting unit relative to the cutting level, depending on this height.

US Pat. No. 10,362,726

ON-THE-GO SOIL SENSORS AND CONTROL METHODS FOR AGRICULTURAL MACHINES

Ag Leader Technology, Inc...

5. An apparatus for monitoring and displaying readings associated with a sensor measuring cutting depth of a seed trench on a seeder as the seeder seeds a field, the apparatus comprising:a seeder implement;
a seed firmer on the seeder implement;
a sensor mounted on the seed firmer by incorporation into a base, side, or base and sides of the seed firmer and measures height of a seed furrow sidewall of the seed trench; and
a display associated with the seeder adapted to display a representation of cutting depth of the seed trench based on the sensor.

US Pat. No. 10,362,723

HAND-OPERATED SPREADER

1. A hand-operated spreader comprising:a base having a transmission mechanism with an operating arm and a rotating disk driven by the transmission mechanism;
an assembly member disposed above the rotating disk of the base, an open end provided on a side of the assembly member and configured for distributing, a limiting portion with a continuous curve provided on the open end, a feeding opening provided at a center portion of the assembly opposite engaging slots disposed on a circular sidewall corresponding to a container;
a feeding rudder rotatably mounted in the feeding opening of the assembly member, the feeding rudder having an inclined surface and a through aperture on the inclined surface, the feeding rudder further having a rotating handle extending from the open end of the assembly member and configured to move along the limiting portion with a plurality of predetermined positions;
an adjusting member rotatably mounted inside the circular sidewall of the feeding opening, the circular sidewall having a T-shaped limiting gap for limiting the adjusting member, the adjusting member further having a tapered casing with at least three holes inside the circular sidewall, opposing sides of the three holes provided with a mixing rod; a side of the adjusting member provided with a control handle extending from the limiting gap, a guiding slot disposed on the assembly member, the guiding slot having a slidable limiting bar for moving the control handle; and
a feeding cone fixed in the circular sidewall of the feeding opening and overlaying the tapered casing of the adjusting member and having at least three feeding apertures corresponding to the three holes of the tapered casing.
US Pat. No. 10,362,788

HELICOVERPA ARMIGERA SINGLE NUCLEOPOLYHEDROVIRUS (HEARSNPV) GENOTYPES, METHOD OF PRODUCING SAME AND USE AS A BIOLOGICAL CONTROL AGENT

1. An occlusion body comprising occlusion-derived virions,wherein occlusion-derived virions of at least two different genotypes are co-occluded in the occlusion body, and
wherein the genotypes are selected from the group of Helicoverpa armigera single nucleopolyhedrovirus genotypes consisting of HearSNPV-SP1B (CNCM I-4806) and HearSNPV-LB6 (CNCM I-4807).
US Pat. No. 10,363,301

STABILIZED INFLUENZA HEMAGGLUTININ STEM REGION TRIMERS AND USES THEREOF

The United States of Amer...

1. A nanoparticle comprising a protein construct that comprises an HA protein domain and a linker sequence, wherein the HA protein domain comprises the sequence of an influenza hemagglutinin (HA) protein that lacks at least 95% of the head region amino acid sequence, and in place of the missing sequence comprises a linker sequence, wherein the linker sequence is less than 10 amino acids in length; and,wherein the HA protein comprises at least one alteration selected from the group consisting of:
a. deletion of the amino acid region corresponding to amino acids N403-W435 of SEQ ID NO:8; and,
b. substitution of at least one amino acid residue in a pair of amino acid residues, wherein the amino acid residues correspond to K1 and E53 of SEQ ID NO:149; and, wherein the strength of the bond between the amino acid pair in the folded, altered protein is greater than the strength of the bond between the amino acid pair in the folded, wild-type protein.
US Pat. No. 10,363,302

INFLUENZA NUCLEIC ACID MOLECULES AND VACCINES THEREFROM

THE TRUSTEES OF THE UNIVE...

1. An isolated nucleic acid molecule comprising one or more nucleic acid molecules selected from the group consisting of:i) a nucleic acid molecule encoding the amino acid sequence of SEQ ID NO:2,
ii) a nucleic acid molecule encoding the amino acid sequence of SEQ ID NO:4,
iii) a nucleic acid molecule encoding the amino acid sequence of SEQ ID NO:7,
iv) a nucleic acid molecule encoding the amino acid sequence of SEQ ID NO:10, and
v) a nucleic acid molecule encoding the amino acid sequence of SEQ ID NO:12.
US Pat. No. 10,364,326

POROUS/NANOPOROUS PHT

International Business Ma...

1. A polymeric material comprising a plurality of hexahydrotriazine units, hemiaminal units, or both bonded together by a first linkage and a second linkage, wherein the first linkage is thermally stable and resistant to bases and the second linkage is thermally degradable and degradable by a base.
US Pat. No. 10,363,304

PURIFICATION OF HERPES VIRUS

SANOFI PASTEUR BIOLOGICS,...

1. A composition comprising Herpes Simplex Virus (HSV) particles in a liquid stabilization buffer, wherein the liquid stabilization buffer comprises glutamate, 1-20 mM histidine and optionally glutamine, a salt, and a sugar, and wherein other than histidine and optionally glutamine, the liquid stabilization buffer does not contain any other amino acids.
US Pat. No. 10,364,328

METHOD FOR PRETREATING LIGNOCELLULOSE BY USING ACID-BASE MIXTURE CATALYST

Korea University Research...

1. A method for pretreating lignocellulosic biomass comprising:reacting an aqueous acid-base mixture catalyst having a pH value of 1 to 4 with lignocellulosic biomass at 100 to 200° C. for 60 seconds to 2 hours;
wherein the acid is selected from the group consisting of sulfuric acid, maleic acid, hydrochloric acid, nitric acid, phosphoric acid, carbonic acid, formic acid, acetic acid, hydrofluoric acid, oxalic acid, citric acid, and mixtures of two or more thereof;
wherein the base is selected from the group consisting of sodium hydroxide, potassium hydroxide, calcium hydroxide, barium hydroxide, ammonium hydroxide, calcium carbonate, potassium carbonate, ammonia, and mixtures of two or more thereof; and
wherein said acid-base mixture catalyst has an acid:base molar ratio of 4:1, and has a total concentration of 0.05 M to 0.5 M.
US Pat. No. 10,364,329

THERMOPLASTIC RESIN COMPOSITION AND MOLDED ARTICLE INCLUDING THE SAME

LG CHEM, LTD., Seoul (KR...

1. A thermoplastic resin composition, comprising: 100 parts by weight of a base resin comprising (a) an aromatic vinyl compound-conjugated diene-based compound-vinyl cyan compound copolymer and (b) an aromatic vinyl compound-vinyl cyan compound copolymer comprising ?-methylstyrene; and (c) between 0.5 parts by weight and 5 parts by weight of a polyethylene oxide-polypropylene oxide triblock copolymer,wherein (a) the aromatic vinyl compound-conjugated diene-based compound-vinyl cyan compound copolymer is comprised in an amount of 10% by weight to 50% by weight with respect to the base resin,
wherein (b) the aromatic vinyl compound-vinyl cyan compound copolymer is comprised in an amount of 50% by weight to 90% by weight with respect to the base resin, and
wherein a number average molecular weight (Mn) of the polypropylene oxide is 1,000 to 1,750 g/mol.
US Pat. No. 10,362,794

THRAUSTOCHYTRIDS, FATTY ACID COMPOSITIONS, AND METHODS OF MAKING AND USES THEREOF

DSM IP Assets B.V., TE H...

1. A microbial oil comprising a triglyceride fraction of from 75% to 95% by weight, wherein the docosahexaenoic acid content of the triglyceride fraction is from 40% to 80% by weight, wherein the arachidonic acid content of the triglyceride fraction is from 0.1% by weight to 1.5% by weight, wherein said microbial oil further comprising an effective amount of at least one added antioxidant to provide oxidative stability.
US Pat. No. 10,363,306

CYTOKINES AND NEUROANTIGENS FOR TREATMENT OF IMMUNE DISORDERS

East Carolina University,...

1. A method of treating multiple sclerosis in a subject comprising administering to the subject an effective amount of a composition comprising:(a) at least one fusion protein comprising, from N-terminal to C-terminal, (i) a cytokine, wherein the cytokine is interferon-? (IFN-?); (ii) optionally an enterokinase linking moiety, wherein the enterokinase linking moiety is (1) an amino acid sequence of SEQ ID NO:1, (2) an amino acid sequence having at least 80% identity or homology with the amino acid sequence of SEQ ID NO:1, (3) an amino acid sequence encoded by a nucleic acid sequence encoding an enterokinase recognition site, or (4) an amino acid sequence encoded by a nucleic acid sequence that hybridizes with the complement of the nucleic acid sequence of (3) under stringent conditions as represented by hybridization conditions of 0.5M NaHPO4, 7% sodium dodecyl sulfate (SDS), 1 mM EDTA at 65° C. and wash conditions of 0.1×SSC/0.1% SDS at 68° C.; and (iii) an autoimmune antigen, or portion thereof, wherein the autoimmune antigen is myelin basic protein (MBP);
(b) a cytokine, wherein the cytokine is IFN-?; and
(c) a pharmaceutically acceptable carrier, excipient or diluent.
US Pat. No. 10,364,330

PROCESS TO PREPARE BIAXIALLY ORIENTED FILM

DSM IP ASSETS B.V., Heer...

1. A process for preparing a biaxially oriented film, comprising the following steps:a) forming a polymer melt by melting a polymer composition comprising at least 50 wt % with respect to the total amount of the composition of a copolyamide comprising:
(i) at least 75 wt % monomeric units derived from caprolactam, and further monomeric units derived from diamines X and/or diacids Y and/or aminoacids Z in a summed amount of between 0.2 to 10 wt %; or
(ii) at least 75 wt % monomeric units derived from hexamethylene diamine and adipic acid, and further monomeric units derived from diamines X, diacids Y and/or aminoacids Z in a summed amount of between 0.2 to 10 wt %; wherein
at least one of the further monomeric units derived from diamines X and/or diacids Y and/or amino acids Z is cyclic;
b) casting the polymer melt through a planar die to form a film of at least one layer and subsequently quenching the film to a temperature of below Tg of the copolyamide;
c) stretching the film obtained after quenching in a direction parallel to a machine direction (MD-stretching) with a factor of at least 2 at a temperature of at least Tg of the copolyamide to obtain a MD-stretched film;
d) stretching the MD-stretched film obtained after MD stretching in a direction transverse to the machine direction (TD-stretching) with a factor of at least 2 at a temperature of at least Tg+10° C. of the copolyamide to obtain a biaxially stretched film;
e) cooling the obtained biaxially stretched film after TD-stretching at a temperature of at least 10° C. lower than the temperature of the TD-stretching in step d); and
f) heat setting the biaxially stretched film obtained after cooling, at a temperature of between Tm?70° C. and Tm of the copolyamide to obtain a biaxially oriented film; wherein
the temperatures Tg and Tm of the copolyamide are determined as described by ASTM D3418-03.
US Pat. No. 10,363,307

METHODS OF TREATING PSORIATIC ARTHRITIS USING IL-17 ANTAGONISTS

Novartis AG, Basel (CH)

1. A method of treating Psoriatic Arthritis (PsA), comprising:a) subcutaneously administering to a patient having PsA five doses of about 150 mg-about 300 mg of an IL-17 antibody, each of the five doses being delivered weekly; and
b) thereafter, subcutaneously administering to the patient a dose of about 150 mg-about 300 mg of the IL-17 antibody every month, wherein the IL-17 antibody comprises:
i) an immunoglobulin VH domain comprising the amino acid sequence set forth as SEQ ID NO:8 and an immunoglobulin VL domain comprising the amino acid sequence set forth as SEQ ID NO:10;
ii) an immunoglobulin VH domain comprising the hypervariable regions comprising the amino acid sequences set forth as SEQ ID NOs:1-3, respectively, and an immunoglobulin VL domain comprising the hypervariable regions comprising the amino acid sequences set forth as SEQ ID NOs:4-6, respectively; or
iii) an immunoglobulin VH domain comprising the hypervariable regions comprising the amino acid sequences set forth as SEQ ID NOs:11-13, respectively, and an immunoglobulin VL domain comprising the hypervariable regions comprising the amino acid sequences set forth as SEQ ID NOs:4-6, respectively.
US Pat. No. 10,362,796

METHOD FOR REDUCING THE CONTENT OF PATHOGENIC ORGANISMS PRESENT IN FOOD MATERIALS

1. A fermented food product produced by a method comprising:(i) mixing a food material with (a) a starter culture and (b) at least one adjunct culture comprising Pediococcus acidilactici that produces a bacteriocin;
(ii) fermenting the food material at a sub-optimal temperature for growth of the Pediococcus acidilactici of 30° C. or below; and
(iii) ripening the food material;
wherein during fermentation the acidification caused by the Pediococcus acidilactici is about 0.5 pH unit or less, and wherein growth of Listeria monocytogenes during fermentation and/or ripening is suppressed, and
wherein the pH of the fermented food product is at most 0.5 pH units lower than that of a fermented food product produced by the same method except without the Pediococcus acidilactici adjunct culture.
US Pat. No. 10,363,309

TARGETED NANOPARTICLE CONJUGATES

CASE WESTERN RESERVE UNIV...

1. A composition for treating a disorder in a subject, the composition comprising:a polyethylene glycolylated (PEGylated) nanoparticle;
at least one hydrophobic therapeutic agent non-covalently coupled to the surface of the nanoparticle, wherein the at least one hydrophobic therapeutic agent has an amino or amine functionality for attachment to the surface of the nanoparticle; and
at least one targeting moiety coupled to polyethylene glycol of the nanoparticle for targeting the composition to a cell associated with the disorder, wherein the at least one therapeutic agent is released from the nanoparticle and differentially up taken by the cell upon targeting with reduced nanoparticle accumulation in the cell.
US Pat. No. 10,363,310

PROTON INDUCED BORON CAPTURE THERAPY

1. A method of treating a biological tissue using a proton beam, comprising steps of:introducing a reactant into a biological tissue, the reactant comprising a composite and being distributed in the biological tissue; and
irradiating the biological tissue with the proton beam,
wherein the composite comprises 10B and 11B, the composite reacts with at least one proton from the proton beam to release at least one ? particle or ? rays, and the ? particle or the ? rays reacts with the biological tissue.
US Pat. No. 10,363,311

ENGINEERED PRIMATE CYSTINE/CYSTEINE DEGRADING ENZYMES AS ANTINEOGENIC AGENTS

BOARD OF REGENTS, THE UNI...

1. An isolated, modified primate cystathionine-?-lyase (CGL) enzyme having at least one substitution relative to a native primate CGL amino acid sequence (see SEQ ID NOs: 1 and 7-10), said at least one substitution including a threonine at position 59 of the native primate CGL sequence.
US Pat. No. 10,362,800

POWDEROUS VITAMIN E FORMULATIONS

DSM IP ASSETS B.V., Heer...

1. A powderous formulation comprising:(i) at least 40 wt-%, based on the total weight of the powderous formulation, of a porous particulate carrier material,
(ii) at least 50 wt-%, based on the total weight of the powderous formulation, of vitamin E coated onto the porous particulate carrier material, and
(iii) 0.5 wt-%-8 wt-%, based on the total weight of the powderous formulation, of at least one auxiliary compound selected from the group consisting of aluminium ammonium sulphate, aluminium potassium sulfate, ammonium acetate, ammonium bisulphite, ammonium carbonate, ammonium chloride, ammonium dihydrogen phosphate ammonium hydrogen carbonate, bentonite, montmorillonite, calcium aluminates, calcium carbonate, calcium silicate, synthetic calcium sulphate di-hydrate, calcium sulfate, kaolinitic clays, diatomaceous earth, perlite, potassium bisulphite, potassium hydrogen carbonate, potassium sulphate, potassium carbonate, sepiolitic clays, silicic acid, synthetic sodium aluminosilicate, sodium aluminosulfate, sodium bisulphate, sodium carbonate, sodium chloride, sodium hydrogen carbonate, sodium sulphate, vermiculite, calcium carbonate, magnesium carbonate, calcareous marine algae, magnesium oxide, magnesium sulphate, dicalcium phosphate, tri-calcium phosphate, dicalcium phosphate, defluorinated rock-phosphate, monocalcium phosphate, calcium-magnesium phosphate, mono-ammonium phosphate, magnesium phosphate, sodium-calcium-magnesium phosphate, mono-sodium phosphate, glycerol, propylene glycol, glyceryl triacetate, sorbitol, polydextrose, lactic acid and urea, wherein
the at least one auxiliary compound has an average particle size (d 0.5) of 54-100 ?m in the formulation, and wherein
the powderous formulation has a minimum ignition energy (MIE) value according to EN 13821:2002 of 10 to 1000 mJ.
US Pat. No. 10,363,312

PHARMACEUTICAL COMPOSITIONS COMPRISING MELOXICAM

AXSOME THERAPEUTICS, INC....

1. A method of treating migraine comprising: orally administering a solid dosage form once daily to a human being suffering from a migraine, wherein the solid dosage form comprises: 1) a complex of meloxicam and a sulfobutyl ether ?-cyclodextrin (SBE?CD), and 2) a bicarbonate, wherein orally administering the solid dosage form to the human being results in a Tmax of meloxicam that is shorter than a Tmax of a reference solid dosage form that: 1) contains the same amount of meloxicam, 2) does not contain an SBE?CD, and 3) does not contain a bicarbonate, wherein the solid dosage form has been shown to have a median Tmax of meloxicam that is less than 2 hours in human subjects.
US Pat. No. 10,362,801

WRAPPING PAPER HAVING TRANSPARENT REGIONS

delfortgroup AG, Traun (...

1. A wrapping paper for smoking articles, which contains pulp fibers and at least one acid-soluble filler material, wherein the content of acid-soluble filler material is at least 10% by weight with respect to the total mass of the wrapping paper, wherein the wrapping paper has regions of lower transparency and regions of higher transparency, wherein the fraction of the mass per unit area of said acid-soluble filler material is at least 10% lower in the regions of higher transparency than in the regions of lower transparency, and wherein for the transparency in the regions of higher transparency, at least one of the following criteria is met:the transparency measured in accordance with DIN 53147:1993-01 in the regions of higher transparency is at least 20% higher than the transparency measured in accordance with DIN 5314:1993-01 in the regions of lower transparency, or
the transparency in the regions of higher transparency is so much higher than in the regions of lower transparency that, when the wrapping paper is wrapped around a tobacco rod with an American Blend tobacco blend, a diameter of 7 mm to 8 mm and a filling density of 0.1 g/cm3 to 0.3 g/cm3, a pattern of lighter and darker sections is obtained which is perceptible to the naked eye, wherein the darker sections correspond to the regions of higher transparency and the lighter sections correspond to the regions of lower transparency.
US Pat. No. 10,363,315

COMPOSITION FOR TREATMENT OF A DETACHED RETINA AND METHOD OF PRODUCTION THEREOF

University of Liverpool, ...

1. A composition for medical use in treatment of a detached retina, the composition comprising an oil and an additive capable of increasing the extensional viscosity of the oil, wherein the oil has a viscosity of less than 5,000 mPas and is at least one selected from the group consisting of: a silicone oil, a perfluorocarbon oil, and a semi-fluorinated alkane oil, wherein the additive is a silicone oil having a viscosity of 2,500,000 mPas, and is present in the range of 0.05%-20% w/w of the composition, the composition effective to prevent formation of an emulsion with protein, for the medical use of the composition in the treatment of the detached retina.
US Pat. No. 10,367,157

ENERGY SENSITIZATION OF ACCEPTORS AND DONORS IN ORGANIC PHOTOVOLTAICS

University of Southern Ca...

1. An organic photosensitive optoelectronic device comprising:two electrodes in superposed relation;
a mixed organic acceptor layer and an organic donor layer located between the two electrodes, wherein the mixed organic acceptor layer comprises a mixture of an acceptor material and at least one acceptor sensitizer, wherein the acceptor material is chosen from fullerenes and fullerene derivatives, and wherein the acceptor material and the at least one acceptor sensitizer are chosen to satisfy the following conditions:
the at least one acceptor sensitizer has a lowest singlet excited state energy (ES-ASens) greater than or equal to a lowest singlet excited state energy (ES-A) of the acceptor material;
the at least one acceptor sensitizer has a lowest triplet excited state energy (ET-Asens) greater than or equal to a lowest triplet excited state energy (ET-A) of the acceptor material;
the at least one acceptor sensitizer has a reduction potential lower than or equal to a reduction potential of the acceptor material; and
if the at least one acceptor sensitizer and the acceptor material form a charge transfer (CT) state having a CT state energy, the CT state energy is greater than or equal to the lowest triplet excited state energy (ET-A) of the acceptor material.
US Pat. No. 10,364,344

THERMOPLASTIC RESIN COMPOSITION EXHIBITING SUPERIOR MATTE AND GLOSS, AND MOLDED ARTICLE MANUFACTURED FROM THE SAME

LG CHEM, LTD., Seoul (KR...

1. A thermoplastic resin composition, comprising:10 to 59% by weight of an acrylic graft copolymer resin (a) having a graft efficiency of 50 to 95%, the resin (a) comprising 10 to 60% by weight of an acrylic rubber, 30 to 60% by weight of an aromatic vinyl compound, and 10 to 30% by weight of a vinyl cyan compound;
1 to 20% by weight of an acrylic graft copolymer resin (b) having a graft efficiency of 10-20%, the resin (b) comprising 60 to 95% by weight of an acrylic rubber, 1 to 30% by weight of an aromatic vinyl compound, and 1 to 20% by weight of a vinyl cyan compound; and
21 to 89% by weight of an aromatic vinyl compound-vinyl cyan compound copolymer resin (c),
wherein a weight ratio of (a):(b) is 1:1 to 10:1.
US Pat. No. 10,363,321

NUCLEIC ACID PRODUCTS AND METHODS OF ADMINISTRATION THEREOF

Factor Bioscience Inc., ...

1. An in vivo method for treating cancer in a subject comprising:administering to the subject by intratumoral injection a non-viral, cell-free composition comprising a synthetic messenger RNA (mRNA) encoding a gene-editing protein capable of creating a single-strand or double-strand break in an immune checkpoint molecule gene, and
causing a single-strand or double-strand break in the DNA of a tumor cell, the single-strand or double-strand break being localized to an immune checkpoint molecule gene in the tumor cell in the subject, resulting in the stimulation or enhancement of an immune response in the subject;thereby treating cancer in the subject.
US Pat. No. 10,364,348

THERMOPLASTIC RESIN COMPOSITION AND MOLDED ARTICLE COMPRISING THE SAME

Lotte Advanced Materials ...

1. A thermoplastic resin composition comprising:about 100 parts by weight of a base resin comprising about 65 wt % to about 80 wt % of a polycarbonate (PC) resin and about 20 wt % to about 35 wt % of a polyester resin;
about 20 parts by weight to about 40 parts by weight of inorganic fillers; and
about 3 parts by weight to about 15 parts by weight of an aromatic (meth)acrylate polymer;
wherein the aromatic (meth)acrylate polymer is a copolymer of a monomer mixture comprising a vinyl cyanide monomer, an aromatic vinyl monomer and an aromatic (meth)acrylate.
US Pat. No. 10,364,351

PROCESS FOR THE MANUFACTURE OF TANKS HAVING HIGH BARRIER PROPERTIES TOWARD FLUIDS

RHODIA OPERATIONS, Auber...

1. A process for making a tank having high barrier properties toward fluids, comprising:assembling one or more components made by injection molding of a polyamide composition, optionally with one or more other components, in order to obtain the tank; said polyamide composition comprising a polyamide and from 5% to 40% by weight of an impact strength modifier, wherein the impact strength modifier has a mean particle size of between 0.1 and 1 ?m and is defined as having an ASTM D-638 tensile modulus of less than about 500 MPa;
said polyamide composition further comprising a novolac resin; and
said polyamide composition exhibiting the following characteristics:
a melt viscosity of between 50 and 700 Pa·s, measured according to the standard ISO 11443, at a shear gradient of 1000 s?1 and a temperature equal to the melting point of the polyamide +35° C.; and
a permeability to SP95 E10 alcohol-blend gasoline of less than or equal to 10 g·mm/m2·day, as measured at a temperature of 40° C. and a relative humidity of 20%,
wherein:
the polyamide composition is devoid of cyclodextrin and silica;
the polyamide composition is substantially free of plasticizers;
the impact strength modifier comprises at least 20% by weight, based on the total weight of the impact strength modifier, of reactive impact strength modifier that comprises functional groups that are reactive with the polyamide, and/or
the polyamide composition further comprises at least 10% by weight, based on the total weight of the impact strength modifier, of a compatibilizing agent that comprises functional groups that are reactive with the polyamide.
US Pat. No. 10,364,363

RADIATION CURABLE BINDER DISPERSION

Hewlett-Packard Developme...

1. A radiation curable binder dispersion, comprising:water; and
a radiation curable polyurethane dispersed in the water, the radiation curable polyurethane having been formed from:
a polyisocyanate;
an acrylate or methacrylate, the acrylate or methacrylate having at least two hydroxyl functional groups and having an acrylate functional group or a methacrylate functional group;
an other acrylate or methacrylate, the other acrylate or methacrylate having one hydroxyl functional group or one amino functional group; and one of:
i) a homopolymer or copolymer of poly(ethylene glycol) having one or two hydroxyl functional groups or one or two amino functional groups at one end of its chain; or
ii) a combination of i and a compound including a carboxylic functional group.
US Pat. No. 10,363,341

COMPOSITE TISSUE-ENGINEERED INTERVERTEBRAL DISC WITH SELF-ASSEMBLED ANNULAR ALIGNMENT

Cornell University, Itha...

1. A method of fabricating a tissue-engineered intervertebral disc (IVD) suitable for total disc replacement in a mammal, said method comprising:providing a first gel comprising a first population of living cells that secrete a hydrophilic protein;
forming the first gel into a predetermined shape and size;
providing a second different gel comprising a second different population of living cells and collagen;
contacting the formed first gel with the second gel at a region that extends circumferentially around the first gel; and
storing the first and second gels under conditions effective for the collagen in the second gel to align circumferentially around the first gel by self-assembly of collagen due to cell-mediated gel contraction in the second gel, wherein the first gel forms a nucleus pulposus structure and the second gel forms an annulus fibrosus structure surrounding and in contact with the nucleus pulposus structure, thereby fabricating a tissue-engineered IVD suitable for total disc replacement in a mammal.
US Pat. No. 10,364,369

LOW DUST ADDITIVES COMPRISING EMULSIFIED POWDER FOR JOINT COMPOUNDS AND JOINT COMPOUNDS THEREOF

Henry Company, LLC, El S...

1. A low-dust joint compound composition comprising a dust reduction additive emulsified powder, wherein said dust reduction additive emulsified powder is made from an emulsion comprising a colloidally-protected-waxed-based (CPWB) microstructure comprising:(A) a wax core,
wherein said wax core comprises a micro-crystalline wax component, a non-micro-crystalline wax component, or a combination thereof,
wherein said micro-crystalline wax component comprises at least one linear alkane wax defined by the general formula CnH2n+2, where n ranges from 13-80,
wherein said non-micro-crystalline wax component comprises at least one wax selected from the group consisting of animal-based wax, plant-based wax, mineral wax, synthetic wax, a wax containing organic acids and/or esters, anhydrides, an emulsifier containing a mixture of organic acids and/or esters, and combinations thereof; and
(B) a polymeric shell,
wherein said polymeric shell comprises at least one polymer selected from the group consisting of polyvinyl alcohol, polyvinyl alcohol copolymers, polyvinyl alcohol terpolymers, polyvinyl acetate, polyvinyl acetate copolymers, polyvinyl acetate terpolymers, cellulose ethers, polyethylene oxide, polyethyleneimines, polyvinylpyrrolidone, polyvinylpyrrolidone copolymers, polyethylene glycol, polyacrylamides polyethylene glycol, polyacrylamides and poly(N-iso-propylamides), pullulan, sodium alginate, gelatin, starches, and combinations thereof.
US Pat. No. 10,364,379

OXAZOLINE-CONTAINING AQUEOUS POLYMER DISPERSIONS FOR COMPOSITE FILM LAMINATION

BASF SE, Ludwigshafen (D...

1. A laminating adhesive, comprising an aqueous polymer dispersion comprising a polymer having a glass transition temperature of less than ?10° C., wherein the polymer comprises, in polymerized form:ethylenically unsaturated, radically polymerizable monomers;
at least one monomer having at least one acid group, in an amount of at least 0.1 part by weight, based on 100 parts by weight of all polymerizable monomers; and
at least one monomer having at least one oxazoline group.
US Pat. No. 10,364,380

ADHESIVE COMPOSITION FOR OPTICAL USE, METHOD FOR PREPARING ADHESIVE COMPOSITION FOR OPTICAL USE, AND ADHESIVE FILM FOR OPTICAL USE

LG Chem, Ltd., (KR)

1. An adhesive composition for optical use, comprising:an isobutylene-isoprene rubber having an acrylic acid ester-based functional group in a main chain thereof;
a photoinitiator; and
a tackifier,
wherein the acrylic acid ester-based functional group is grafted to an isoprene unit of the isobutylene-isoprene rubber through a urethane bond.
US Pat. No. 10,364,381

RELEASE FILM

MITSUBISHI CHEMICAL CORPO...

1. A release film comprising a polyester film and a coating layer formed on at least one surface of the polyester film, which coating layer is formed by coating a coating solution comprising an addition curing silicone compound, a Gemini surfactant, and a platinum group metal catalyst and curing thereof.
US Pat. No. 10,364,382

CURABLE POLYSILOXANE COMPOSITIONS AND PRESSURE SENSITIVE ADHESIVES MADE THEREFROM

3M Innovative Properties ...

1. A curable composition comprising:at least one polydiorganosiloxane, comprising at least two hydroxysilyl moieties; wherein the at least one polydiorganosiloxane, comprising at least two hydroxysilyl moieties comprises the following general formula:
(OH)p—Si(R?)3-p-[G-Si(R?)2]t—O—[(R?)2SiO]q[Si(R?)2G]t—Si(R?)3-p—(OH)p  (I)
wherein each p is independently an integer of 1, 2, or 3; each G is independently a divalent linking group; each R? is independently selected from alkyl, alkenyl, aryl, cycloalkyl, heteroaryl, heterocycloalkyl, and combinations thereof; q is an integer of 0 to 150,000; and each t is independently an integer of 0 or 1
at least one hydroxyl-functional polyorganosiloxane resin; and
at least one photoactivatable composition that, upon exposure to radiation, generates at least one base selected from amidines, guanidines, phosphazenes, proazaphosphatranes, and combinations thereof, wherein the curable composition cures upon exposure to radiation of the appropriate wavelength to activate the photoactivatable composition and upon curing is a pressure sensitive adhesive.
US Pat. No. 10,364,383

ABRASIVE PARTICLES HAVING COMPLEX SHAPES AND METHODS OF FORMING SAME

1. A shaped abrasive particle comprising:a generally prismatic body having a length, width, and thickness;
wherein the length is greater than the width and the length is greater than the thickness;
wherein the generally prismatic body with a first end face and a second end face have a polygonal shape; and
wherein the generally prismatic body comprises an odd number of major surfaces.
US Pat. No. 10,367,200

POSITIVE ELECTRODE ACTIVE MATERIAL SLURRY INCLUDING TWO TYPES OF BINDERS AND POSITIVE ELECTRODE PREPARED THEREFROM

LG Chem, Ltd., (KR)

1. A positive electrode active material slurry comprising:a positive electrode active material;
a first binder;
a second binder; and
an organic solvent,
wherein the first binder is a fluorine-based binder,
the second binder is a butadiene rubber-based binder, and
the first binder and the second binder have a weight ratio of 9:1 to 7:3,
wherein the positive electrode active material is included in 50% by weight to 65% by weight with respect to total solid content of the positive electrode active material slurry,
wherein the positive electrode active material is a lithium iron phosphate-based positive electrode active material represented by the following Chemical Formula 1:
Li1+aFe1-xMx(PO4-b)Xb  [Chemical Formula 1]
wherein, in Chemical Formula 1,
M is Al, Mg, Ni, Co, Mn, Ti, Ga, V, Nb, Zr, Ce, In, Zn, Y or a combination thereof,
X is F, S, N or a combination thereof,
a is ?0.5?a?0.5,
b is 0?b?0.1, and
x is 0?x?0.5.
US Pat. No. 10,362,850

DYE-FREE NAIL VARNISH COMPOSITIONS AND METHODS THEREOF

1. A nail varnishing system, comprising:a nail varnish composition including a plurality of photonic particles, a block copolymer, or both a plurality of photonic particles and a block copolymer, wherein the block copolymer is selected from a poly(styrene-b-isoprene) diblock copolymer, poly(styrenesulfonate-methylbutylene), and polystyrene-poly (2-vinylpyridine); and
a stamp including a pattern of repeating nanostructures, wherein the stamp is configured to transfer the pattern of repeating nanostructures to a coating of the nail varnish composition to provide a pattern of repeating photonic nanostructures on the coating of the nail varnish composition.
US Pat. No. 10,365,411

HARDCOAT FILM, POLARIZING PLATE, LIQUID CRYSTAL DISPLAY, AND METHOD FOR MANUFACTURING HARDCOAT FILM

FUJIFILM Corporation, To...

1. A hardcoat film comprising:a support; and
a hardcoat layer disposed on at least one surface of the support,
wherein the support contains a resin as a main component;
wherein a film thickness of the hardcoat layer exceeds 20 ?m;
wherein the hardcoat layer contains at least a structure derived from a), b), c), d) and g);
wherein:
a) compound which has one alicyclic epoxy group and one ethylenically unsaturated double bond group in a molecule and has a molecular weight equal to or less than 300;
b) compound which has 3 or more ethylenically unsaturated double bond groups in a molecule;
c) radical polymerization initiator;
d) cationic polymerization initiator; and
g) antifoulant which has a plurality of polymerizable unsaturated groups in one molecule;
wherein, on condition that a total solid content of the hardcoat layer is regarded as being 100% by mass, the hardcoat layer contains the structure derived from a) in an amount of 15% to 70% by mass, the structure derived from b) in an amount of 25% to 80% by mass, c) in an amount of 0.1% to 10% by mass, d) in an amount of 0.1% to 10% by mass, and the structure derived from g) in an amount of 1% to 20% by mass;
wherein the hardcoat layer is formed by curing a composition for forming a hardcoat layer containing at least a), b), c), d) and g);
wherein, on condition that a total solid content of the composition for forming a hardcoat layer is regarded as being 100% by mass, the composition contains a) in an amount of 15% to 70% by mass, b) in an amount of 25% to 80% by mass, c) in an amount of 0.1% to 10% by mass, d) in an amount of 0.1% to 10% by mass, and g) in an amount of 1% to 20% by mass;
wherein the pencil hardness of the hardcoat film is 6H or more;
wherein a) compound which has one alicyclic epoxy group and one ethylenically unsaturated double bond group in a molecule and has a molecular weight equal to or less than 300 is epoxycyclohexylmethyl (meth)acrylate;
wherein g) antifoulant which has a plurality of polymerizable unsaturated groups in one molecule contains a fluorine-containing compound;
wherein the fluorine-containing compound has a perfluoropolyether group and a plurality of polymerizable unsaturated groups in one molecule; and
wherein the fluorine-containing compound is compatible and forms covalent bonds with a) and b), and the structure derived from g) is distributed within the hardcoat layer in a film thickness direction in such a state that a percentage of an amount of fluorine in the vicinity of the surface of the hardcoat layer, to an amount of fluorine in the entirety of the hardcoat layer, is higher than 51%.
US Pat. No. 10,367,221

DISTRIBUTED ENERGY STORAGE SYSTEM

The Curators of the Unive...

1. An energy storage system, comprising:a first tank configured for storing an anolyte;
a second tank configured for storing a catholyte;
a reaction cell configured for distribution throughout a transport system and for supplying electrical current to an electrical load of the transport system, said reaction cell being elongate and comprising an anode electrode in fluid communication with the first tank and a cathode electrode in fluid communication with the second tank, said reaction cell further comprising a membrane configured to form an interface between the anode electrode and cathode electrode;
a first pump configured for pumping the anolyte from the first tank through the anode electrode of the reaction cell via a first input supply tube; and
a second pump configured for pumping the catholyte from the second tank through the cathode electrode of the reaction cell via a second input supply tube; and
wherein a length of the reaction cell is substantially greater than a width thereof and the length of the reaction cell is greater than at least one of a width and a length of the transport system, and wherein the membrane has a length substantially equal to the length of the reaction cell such that surface area of the membrane is maximized relative to volume of the reaction cell.
US Pat. No. 10,364,407

KIT AND METHOD FOR CLEANING AND DISINFECTING MEDICAL INSTRUMENTS AND APPLIANCES

1. A kit for machine cleaning and/or disinfecting of medical and/or surgical instruments and/or appliances, characterized in that it comprises:a) a first component which comprises 15 to 30 wt % of alkanolamine, wherein the alkanolamine comprises mono-, di-, and/or triethanolamine, and 10 to 30 wt % of complexing agent; and
b) a second component which comprises at least one enzyme.
US Pat. No. 10,364,409

SOLIDIFICATION MATRIX COMPRISING A CARBOXYLIC ACID TERPOLYMER

Ecolab USA Inc., Saint P...

1. A solid detergent composition comprising:between about 0.1 wt-% and about 20 wt-% of a terpolymer (A), said terpolymer (A) comprising in copolymerized form from about 75% by weight of acrylic acid, of about 20% by weight of 2-acrylamido-2-methylpropanesulfonic acid, and of about 5% by weight of a nonionic monomer of the formula (I)
H2C?CH—CH2?O[EO]17—H  (I)
in which EO is ethylene oxide units;
between about 0.1 wt-% and about 50 wt-% water;
between about 65 wt-% and about 95 wt-% alkali metal carbonate; and
between about 0.5 wt-% and about 10 wt-% at least two surfactants, wherein the at least two surfactants are a fatty alcohol alkoxylate, and an EO/PO copolymer having terminal hydroxyl groups;
wherein the solid detergent composition is dimensionally stable and has a growth exponent of less than 3% if heated at a temperature of 122° F.
US Pat. No. 10,364,414

FILTER BASED SYSTEM FOR CAPTURE OF LYSIS OF SUSPENDED CELLS

LIFE TECHNOLOGIES CORPORA...

1. A cell lysis system comprising:a filter;
a reservoir in fluid communication with the filter and operatively positioned on a first side thereof;
a cell suspension intake in fluid communication with the filter and operatively positioned on the first side thereof;
a lysis solution intake in fluid communication with the filter and operatively positioned on a second side thereof; and
a reversible pump in fluid communication with the filter, wherein the reversible pump has a first operating state to cause fluid flow in a first flow direction through the filter from the first side toward the second side thereof, and a second operating state to cause fluid flow in a second flow direction through the filter from the second side toward the first side thereof;
wherein the cell suspension intake is configured to receive a cell suspension therethrough such that the cell suspension is filtered through the filter and a plurality of cells of the cell suspension are captured on the first side of the filter when the reversible pump is in the first operating state;
wherein the lysis solution intake is configured to receive a lysis solution therethrough such that the lysis solution passes through the filter in the second flow direction when the reversible pump is in the second operating state to lyse and suspend the plurality of cells captured on the first side of the filter to produce a cellular lysate; and
wherein the reservoir is configured to receive the cellular lysate when the reversible pump is in the second operating state.
US Pat. No. 10,364,160

PROCESS FOR PRODUCING POTASSIUM TITANATE

TOHO TITANIUM CO., LTD., ...

1. A method for producing a potassium titanate consisting essentially of:a mixing step that mixes a titanium raw material with a potassium raw material, the titanium raw material comprising 80 to 100 mass % of titanium oxide having a specific surface area of 7 to 50 m2/g, and 0 to 4.5 mass % in total of one or more materials selected from titanium metal and titanium hydride, and the potassium raw material comprising a potassium compound;
a calcination step that calcines a raw material mixture obtained by the mixing step at a calcination temperature of 950 to 990° C.;
a grinding step that grinds a calcined powder obtained by the calcination step using a vibrating mill and an impact pulverizer;
wherein after the calcination step, the method is performed without pH adjustment and without an acid wash;
the vibrating mill is at least one selected from a vibrating rod mill and a vibrating ball mill; and
the impact pulverizer is at least one selected from a high-speed rotary mill, high-speed rotary mill provided with a classifier, a media agitating mill, and a jet mill.
US Pat. No. 10,364,416

CANNABICHROMENIC ACID SYNTHASE FROM CANNABIS SATIVA

NATIONAL RESEARCH COUNCIL...

1. A method of modulating levels of cannabinoid compounds in an organism, cell or tissue, said method comprising:a) introducing a nucleic acid molecule comprising:
i) a nucleotide sequence complementary to a polynucleotide encoding at least a portion of a polypeptide having the sequence set for in SEQ ID NO: 2 or 6 or a polypeptide having at least 99.5% sequence identity to SEQ ID NO: 2 or 6; or
ii) a nucleotide sequence complementary to a polynucleotide having at least, greater than or about 99.5% sequence identity to at least a portion of SEQ ID NO: 1 or 5;
into the organism, cell or tissue to decrease the level of a cannabinoid compound,
wherein the portion comprises greater than, at least or about 15 contiguous nucleotides,
and wherein the nucleic acid molecule is comprised in a construct, to silence cannabichromenic acid synthase gene in the organism, cell or tissue to decrease the level of a cannabinoid compound; or
b) introducing a nucleic acid molecule or construct comprising said nucleic acid molecule, and expressing or over-expressing a polypeptide having cannabichromenic acid synthase activity encoded by said nucleic acid molecule, said nucleic acid molecule comprising
i) a nucleotide sequence encoding a polypeptide having the sequence set for in SEQ ID NO: 2 or 6 or a polypeptide having at least 99.5% sequence identity to SEQ ID NO: 2 or 6;
ii) a nucleotide sequence having at least, greater than or about 99.5% sequence identity to SEQ ID NO: 1 or 5; or
iii) a nucleotide sequence having at least, greater than or about 90% sequence identity to SEQ ID NO: 8 or 9;
in the organism, cell or tissue to increase the level of a cannabinoid compound.
US Pat. No. 10,364,417

INCREASED ALCOHOL TOLERANCE USING THE PNTAB GENE

The United States of Amer...

1. A transformed microorganism,wherein the transformed microorganism contains an alcohol tolerance gene,
wherein the transformed microorganism has a higher alcohol tolerance as compared to a non-transformed microorganism, and
wherein the alcohol tolerance gene is one of pntAB, pntA, and pntB,
wherein each of pntA, pntB, and pntAB is a transhydrogenase gene,
wherein the alcohol tolerance gene comprises a nucleotide sequence having at least 75% similarity to one of SEQ ID NO: 17, SEQ ID NO: 18, SEQ ID NO: 19, SEQ ID NO: 20, SEQ ID NO: 21, and SEQ ID NO: 22, and
wherein the microorganism expresses at least one alcohol tolerance protein, the alcohol tolerance protein being at least one of PntA and PntB.
US Pat. No. 10,367,234

BATTERY HAVING INTEGRATED SAFETY CONTROLLER AND POWER MANAGEMENT CONTROLLER

Microsoft Technology Lice...

1. A battery, comprising:at least one battery cell; and
a printed circuit board (PCB) comprising a safety controller of the at least one battery cell and a power management controller of a device using a power of the battery;
wherein the power management controller comprises power outputs directly outputting a power of the battery to at least one module of the device; and
wherein the safety controller and the power management controller are integrated into the same PCB of the battery; and
wherein the at least one module comprises a display module, wherein the display module is configured to be stacked on top of the battery and comprises a flex having a connection interface of the display module, wherein the flex is configured on top of the PCB and the connection interface is configured to contact the PCB of the battery.
US Pat. No. 10,364,420

DIMERIC REVERSE TRANSCRIPTASE

BIO-RAD LABORATORIES, INC...

1. A polypeptide comprising a first reverse transcriptase and a second reverse transcriptase covalently linked by a heterologous linker, wherein the first reverse transcriptase and the second reverse transcriptase are identical.
US Pat. No. 10,365,189

HISTOLOGICAL SPECIMEN TREATMENT

1. A process for preserving a specimen comprising: using a dissolving compound that can form a plural number of azeotropes; successively and azeotropically vaporizing off the formed azeotropes, the first formed azeotrope being vaporized off by reducing pressure, followed by raising temperature to form the second azeotrope, the second azeotrope being vaporized off by reducing pressure, followed by raising temperature to form the third azeotrope, and the third azeotrope being vaporized off by reducing pressure; wherein a first azeotrope is formed between one or more components of the dissolving compound and specimen-supplied water, a second azeotrope is formed between different components of the dissolving compound, and a third azeotrope is formed between different components of the dissolving compound, the third azeotrope being different from the second azeotrope; and impregnating the specimen with a support medium.
US Pat. No. 10,364,422

CELLULASE ENZYMES HAVING A MODIFIED LINKER AND REDUCED LIGNIN BINDING

IOGEN ENERGY CORPORATION,...

1. A modified cellulase enzyme comprising a cellulase catalytic domain, a modified linker peptide, and a carbohydrate binding module, wherein the amino acid sequence of the modified linker peptide is:(a) a variant of the amino acid sequence of SEQ ID NO: 83 consisting of one or more amino acid substitutions of SEQ ID NO: 83, wherein the one or more amino acid substitutions is selected from the group consisting of G2D, S5T, S6T, S7T, S7N, S8T, S9T, S14T, S17T, S20T, S24T, S26T, S27T, S28T, G34D, S35T, T38A, and V43D of SEQ ID NO: 83, wherein the variant confers at least a 1.2-fold reduction in lignin binding to the modified cellulase enzyme relative to a cellulase enzyme comprising the same cellulase catalytic domain, a linker peptide consisting of the amino acid sequence of SEQ ID NO: 83, and the same carbohydrate binding module, or
(b) a variant of the amino acid sequence of SEQ ID NO: 39 consisting of one or more amino acid substitutions of SEQ ID NO: 39, wherein the one or more amino acid substitutions is selected from the group consisting of R12E and R13E of SEQ ID NO: 39, wherein the variant confers at least a 1.2-fold reduction in lignin binding to the modified cellulase enzyme relative to a cellulase enzyme comprising the same cellulase catalytic domain, a linker peptide consisting of the amino acid sequence of SEQ ID NO: 39, and the same carbohydrate binding module, and
wherein the modified linker peptide is positioned between the cellulase catalytic domain and the carbohydrate binding module and the modified cellulase enzyme exhibits cellulose-hydrolyzing activity.
US Pat. No. 10,364,423

POLYPEPTIDES HAVING BETA-XYLOSIDASE ACTIVITY AND POLYNUCLEOTIDES ENCODING SAME

Novozymes, Inc., Davis, ...

1. A process for degrading or converting a cellulosic or xylan-containing material, the process comprising: treating the cellulosic or xylan-containing material with an enzyme composition and a polypeptide having beta-xylosidase activity, and recovering the degraded or converted cellulosic material; wherein the polypeptide having beta-xylosidase activity is selected from the group consisting of:(a) a polypeptide having at least 95% sequence identity to amino acids 17 to 582 of SEQ ID NO: 6;
(b) a polypeptide encoded by a polynucleotide that hybridizes under very high stringency conditions with the full-length complement of nucleotides 49 to 1746 of SEQ ID NO: 5 or the cDNA of nucleotides 55 to 1763 SEQ ID NO: 3, wherein very high stringency conditions are defined as prehybridization and hybridization at 42° C. in 5×SSPE, 0.3% SDS, 200 micrograms/ml sheared and denatured salmon sperm DNA, and 50% formamide, and washing three times each for 15 minutes using 2×SSC, 0.2% SDS at 70° C.; and
(c) a polypeptide encoded by a polynucleotide having at least 99% sequence identity to nucleotides 49 to 1746 of SEQ ID NO: 5, or the cDNA of nucleotides 49 to 1746 of SEQ ID NO: 5.
US Pat. No. 10,363,400

METHOD TO MAKE TUBE-IN-TUBE BALLOON

BOSTON SCIENTIFIC SCIMED,...

1. A method of making an expandable medical balloon, comprising:disposing an adhesive layer on a tubular parison, the tubular parison comprising polyamide, poly(ether-block-amide), or a combination thereof; and
longitudinally pre-stretching the tubular parison from a first length to a second length; and
radially expanding the tubular parison in a balloon mold, wherein the radial expansion comprises pressuring the assembly at a temperature and a pressure above ambient temperature or up to about 50° C. so as to expand the parison into a medical balloon, the parison having a wall thickness Ta and the medical balloon having a wall thickness Tb.
US Pat. No. 10,364,428

METHODS AND KITS FOR POST-IVT RNA PURIFICATION

Corning Incorporated, Co...

1. A method for nucleic acid purification, comprising:(a) combining a sample comprising at least one nucleic acid with a binding buffer having a pH ranging from about 4 to about 10 to form a solution;
wherein the binding buffer comprises at least one magnetic particle, at least one chaotropic agent, present in a concentration ranging from about 0.2 M to about 6 M, at least one first alcohol, present in a concentration ranging from about 0.1 M to about 5 M, and at least one first salt, present in a concentration ranging from about 10 mM to about 100 mM;
(b) incubating the solution for a time period sufficient to reversibly bind the at least one nucleic acid to the at least one magnetic particle to form at least one modified magnetic particle;
(c) separating the at least one modified magnetic particle from the combined solution;
(d) washing the at least one modified magnetic particle with at least one wash buffer comprising at least one second alcohol and optionally at least one second salt; and
(e) combining the at least one modified magnetic particle with an elution buffer.
US Pat. No. 10,364,429

METHODS AND COMPOSITIONS FOR CONTROLLING EFFICACY OF RNA SILENCING

UNIVERSITY OF MASSACHUSET...

1. A vector encoding an engineered pre-miRNA comprising a RNAi agent comprising a sense strand and an antisense strand that is complementary to a target sequence in a wild-type human mRNA, wherein at least five terminal nucleotides at the 3? end of the antisense strand are substituted with nucleotides which form G:U wobble base pairs with the corresponding nucleotides in the wild-type target human mRNA when compared with a reference antisense strand that is fully complementary to the target sequence, wherein the human mRNA encodes for an oncogene-encoded protein or a tumor suppressor protein.
US Pat. No. 10,364,430

IDENTIFICATION OF A JAK2 MUTATION IN POLYCYTHEMIA VERA

INSTITUT NATIONAL DE LA S...

1. A method for detecting a mutation in the JAK2 (Janus kinase 2) gene of a human patient, comprising:a) obtaining a nucleic acid sample from a human patient; and
b) detecting a thymine (T) in the JAK2 gene at position 2343 of SEQ ID NO: 2 in the nucleic acid sample by:
a1) sequencing a region of the nucleic acid sample comprising position 2343 of SEQ ID NO: 2, or
a2) hybridizing the nucleic acid sample with at least one probe or primer comprising at least 10 consecutive nucleotides of SEQ ID NO: 2 comprising position 2343 of SEQ ID NO: 2, or with a complement of said probe or primer.
US Pat. No. 10,364,432

ANTISENSE OLIGONUCLEOTIDE DIRECTED REMOVAL OF PROTEOLYTIC CLEAVAGE SITES FROM PROTEINS

Academisch Ziekenhuis Lei...

1. A method of promoting production of a human Huntingtin protein lacking a proteolytic caspase-6 cleavage site in a human cell, the method comprising:a) providing a human cell that expresses a human Huntingtin protein comprising a caspase-6 proteolytic cleavage site from a pre-mRNA encoding the protein, with an antisense oligonucleotide that
is directed toward the interior of exon 12 of the human Huntingtin gene;
binds to the pre-mRNA to form a double-stranded nucleic acid complex; and
induces partial skipping of exon 12,wherein at least nucleotides 207 to 341 of exon 12 are skipped;wherein each nucleotide of the antisense oligonucleotide is chemically modified to render the double-stranded nucleic acid complex RNase H resistant; andb) allowing translation of mRNA produced from the pre-mRNA in the cell to produce an mRNA lacking nucleotides 207 to 341 of exon 12;wherein the anti-sense oligonucleotide comprises or consists of a sequence selected from SEQ ID NO:178 and 182.
US Pat. No. 10,364,177

GLASS COMPOSITIONS HAVING HIGH THERMAL AND CHEMICAL STABILITY AND METHODS OF MAKING THEREOF

Corning Incorporated, Co...

wherein:(i) the glass satisfies the relationship:
1.15??(MgO+CaO+SrO+BaO)/(Al2O3)?1.50,where Al2O3, MgO, CaO, SrO, and BaO represent the mole percents of the respective oxide components,(ii) when the glass comprises the optional component SrO, the glass satisfies the relationship:
BaO/SrO?2.0,where BaO and SrO represent the mole percents of the respective oxide components,(iii) the amount of any oxide in the glass other than SiO2, Al2O3, B2O3, MgO, CaO, SrO, BaO, and La2O3 is less than or equal to 2.0 mole percent,
(iv) the glass has a strain point greater than or equal to 700° C.,
(v) the glass exhibits a dimensional change of less than 30 ppm for a 5 minute heat treatment at 600° C., and
(vi) the glass has a Young's modulus to density ratio greater than or equal to 28.0 GPa·cm3/g.
US Pat. No. 10,364,178

GLASSES HAVING IMPROVED TOUGHNESS AND SCRATCH RESISTANCE

CORNING INCORPORATED, Co...

1. A silicate glass, the silicate glass being ion exchangeable and comprising:62-70 mol % SiO2;
0-18 mol % Al2O3;
>0-10 mol % B2O3;
>0-15 mol % Li2O;
6-20 mol % Na2O;
0-18 mol % K2O;
>0-17 mol % MgO;
ZrO2; and
SnO2,
wherein 10 mol %?Al2O3+B2O3+ZrO2?30 mol %, and
wherein 14 mol %?R2O+R?O?25 mol %, where R is at least one of Li, Na, K, Rb, and Cs, and R? is at least one of Mg, Ca, Sr, and Ba, and
wherein ?15 mol %?(R2O+R?O?Al2O3?ZrO2)?B2O3?4 mol %.
US Pat. No. 10,364,435

IMMUNIZATION AND/OR TREATMENT OF PARASITES AND INFECTIOUS AGENTS BY LIVE BACTERIA

1. A genetically engineered chimeric peptide, comprising:a therapeutic peptide portion selected from the group consisting of:
a Bacillus thuringiensis toxin,
a Photorhabdus species insecticidal cytotoxin,
a Xenorhabdus species insecticidal cytotoxin,
anthelmintic cyclic heptapeptide segetalin D, and
a cyclodepsipeptid,
effective to provide a selective cytotoxic therapy of a parasitic disease caused by a parasite, the therapeutic peptide portion being toxic to the parasite;
a targeting peptide portion comprising a parasite targeting (binding) peptide, effective to selectively target the therapeutic peptide portion to at least one cell of the parasite; and
a secretion peptide portion selected from the group consisting of an autotransporter peptide, an HlyA peptide, an HlyB peptide, a type I secretion system active peptide, a type III secretion system active peptide, a colicin release peptide, a bacteriophage release peptide, Lpp-OmpA fusion, M13pIII, and a C-terminal RTC protein, effective to cause secretion of the chimeric peptide from a genetically engineered microorganism which produces the chimeric peptide,
wherein the therapeutic peptide portion, the targeting peptide portion, and the secretion peptide portion of the chimeric peptide are derived by gene fusion from different genes.
US Pat. No. 10,364,436

COMPOSITIONS AND METHODS FOR CLOSTRIDIAL TRANSFORMATION

Danisco US Inc., Palo Al...

1. A recombinant Clostridium bacterial cell comprising:a) a plasmid comprising the sequence of SEQ ID NO: 14, and
b) at least one shuttle plasmid comprising the sequence of any one of SEQ ID NOs: 15-20, wherein the shuttle plasmid further comprises one or more nucleic acid(s) of interest.
US Pat. No. 10,364,181

ANTIMICROBIAL ARTICLES WITH SILVER-CONTAINING ALKALI SILICATE COATING AND METHODS OF MAKING THEREOF

CORNING INCORPORATED, Co...

10. An antimicrobial article comprising:a substrate; and
a coating on a surface of the substrate, the coating comprising at least one of a silver-containing alkali aluminosilicate and a silver-containing alkali borosilicate,
wherein the antimicrobial article has an antimicrobial efficacy of greater than or equal to about 90.0% according to EPA Test Method for Efficacy of Copper Alloy Surfaces as a Sanitizer.
US Pat. No. 10,364,183

COMPOSITE COMPRISING A MINERAL WOOL COMPRISING A SUGAR

SAINT-GOBAIN ISOVER, Cou...

1. A process for preparing a shaped composite, the process comprising:mixing fragments of mineral wool sized with a sizing composition comprising a sugar with a non-cement silica carrier distinct from the wool, a non-cement alkali metal carrier distinct from the wool, and water, to obtain a mixture, wherein the non-cement silica carrier and the non-cement alkali metal carrier form, with the water, a mineral binder that gradually solidifies around solid particles present in the mixture; and then
shaping the mixture into a shaped composite.
US Pat. No. 10,364,439

PESTICIDAL GENES AND METHODS OF USE

AGBIOME, INC., Research ...

19. A method for increasing yield in a plant, said method comprising growing in a field a plant or seed thereof having stably incorporated into its genome a DNA construct comprising a promoter that drives expression in the plant operably linked to a nucleotide sequence that encodes a pesticidal polypeptide, wherein said nucleotide sequence comprises(a) a nucleotide sequence that encodes a polypeptide comprising the amino acid sequence of SEQ ID NO:79; or
(b) a nucleotide sequence that encodes a polypeptide comprising an amino acid sequence having at least 95% sequence identity to the amino acid sequence of SEQ ID NO:79, wherein said polypeptide has pesticidal activity against at least one of Lepidopteran or Coleopteran pests.
US Pat. No. 10,364,442

CRISPR ENABLED MULTIPLEXED GENOME ENGINEERING

The Regents of the Univer...

1. A method for tracking a multitude of genome edits in a cell population, comprising:a) introducing into a first population of cells a first vector that encodes:
(i) at least one editing cassette wherein the at least one editing cassette comprises
a) a region homologous to a target region of a nucleic add and comprising a mutation of at least one nucleotide relative to the target region, and
b) a mutation preventing nuclease binding at a protospacer adjacent motif (PAM);
(ii) at least one promoter; and
(iii) a region encoding at least one guide RNA comprising a region complementary to the target region, thereby producing a second population of cells that comprise the first vector;
b) maintaining the second population of cells under conditions n which a nuclease is expressed thereby producing a cell library that comprises a genome edit and comprises the mutation preventing nuclease binding at the PAM; and
c) tracking the multitude of genome edits in the cell library by sequencing the editing cassette of the first vector from at east one cell in the cell library or sequencing the target region of at least one cell in the cell library.
US Pat. No. 10,364,445

PROCESSES OF PRODUCING FERMENTATION PRODUCTS

1. A method of dewatering whole stillage comprising:(a) liquefying a starch-containing material with an alpha-amylase; optionally pre-saccharifying the liquefied material before step (b);
(b) saccharifying the liquefied material;
(c) fermenting using a fermentation organism;
(d) separating the fermented material into a fermentation product and whole stillage;
(e) dewatering the whole stillage;
wherein a carbohydrate-source generating enzyme and a cellulolytic composition comprising a beta-glucosidase having a Relative ED50 loading value of less than 1.00 are present or added during the optional presaccharification step, saccharification step (b), and/or fermentation step (c), or simultaneous saccharification and fermentation, and wherein the beta-qlucosidase is the Aspergillus fumiqatus beta-qlucosidase of SEQ ID NO: 6 or a variant thereof having at least 85% sequence identity to the amino acid sequence of SEQ ID NO: 6 and which comprises one or more substitutions selected from the group consisting of L89M, G91L, F100D, I140V, I186V, S283G, N456E, and F512Y.
US Pat. No. 10,364,192

METHOD FOR FORMING SINTERED CERAMIC MATERIAL

King Fahd University of P...

1. A process for forming a sintered Ca-SiAlON ceramic containing aluminum particles, comprising:mixing
calcium oxide;
silicon nitride;
alumina;
aluminum nitride; and
1.8 wt % to 10 wt % of aluminum particles to form a powder mixture, wherein wt % is based on the total weight of the powder mixture;
spark plasma sintering the powder mixture under a uniaxial pressure of from 20 to 55 MPa to form the sintered Ca-SiAlON ceramic; and
cooling the sintered Ca-SiAlON ceramic to a temperature ranging from 20-40° C.
US Pat. No. 10,364,449

FERMENTATIVE PRODUCTION OF OLIGOSACCHARIDES

1. A method for producing difucosyllactose, said method comprising the step of culturing, in a culture medium containing an exogenously added acceptor and a genetically modified E. coli of LacY+ genotype having a H. pylori futC gene that encodes an ?-1,2-fucosyl transferase that is (a) capable of modifying said acceptor and (b) is necessary for the synthesis of said difucosyllactose from said acceptor wherein the acceptor consists of 2?-O-fucosyllactose.
US Pat. No. 10,364,450

PRODUCTION OF STEVIOL GLYCOSIDE IN RECOMBINANT HOSTS

EVOLVA SA, Reinach (CH)

1. A recombinant host cell capable of producing a steviol glycoside, a glycosylated ent-kaurenol compound, and/or a glycosylated ent-kaurenoic acid compound in a cell culture, comprising a gene encoding a polypeptide capable of selectively converting rubusoside to stevioside and having 95% or greater sequence identity to the amino acid sequence set forth in SEQ ID NO:17 or 18 and a first gene encoding a first polypeptide capable of beta 1,2 glycosylation of the C2? of the 13-O-glucose, 19-O-glucose, or both 13-O-glucose and 19-O-glucose of the steviol glycoside and having 95% or greater sequence identity to the amino acid sequence set forth in SEQ ID NO:16; wherein the recombinant host cell further comprises one or more of:(a) a second gene encoding a second polypeptide capable of beta 1,2 glycosylation of the C2? of the 13-O-glucose, 19-O-glucose, or both 13-O-glucose and 19-O-glucose of the steviol glycoside,
having 95% or greater sequence identity to the amino acid sequence set forth in SEQ ID NO:11;
(b) a gene encoding a polypeptide capable of glycosylating steviol or the steviol glycoside at its C-13 hydroxyl group
having 95% or greater sequence identity to the amino acid sequence set forth in SEQ ID NO:7; and
(c) a gene encoding a polypeptide capable of beta 1,3 glycosylation of the C3? of the 13-O-glucose, 19-O-glucose, or both 13-O-glucose and 19-O-glucose of the steviol glycoside
having 95% or greater sequence identity to the amino acid sequence set forth in SEQ ID NO:9; or
(d) a gene encoding a polypeptide capable of glycosylating steviol or a steviol glycoside at its C-19 carboxyl group, wherein the polypeptide comprises a polypeptide having 95% or greater sequence identity to the amino acid sequence set forth in SEQ ID NO:4;
wherein at least one of the genes is a recombinant gene.
US Pat. No. 10,364,451

POLYMER CONJUGATES HAVING REDUCED ANTIGENICITY AND METHODS OF USING THE SAME

Duke University, Durham,...

1. A method of reducing the antigenicity of a molecule, the method comprising conjugating at least one branched polymer to a molecule to form a molecule-polymer conjugate,wherein the molecule comprises a polypeptide, a polynucleotide, a small molecule, or a combination thereof,
wherein the branched polymer comprises poly[oligo(ethylene glycol) methyl ether methacrylate] (POEGMA),wherein the POEGMA comprises:a backbone comprising poly(methyl methacrylate); and
a plurality of side chains covalently attached to the backbone, where each side chain comprises 2 to 9 monomers of ethylene glycol (EG) repeated in tandem;
wherein the molecule-polymer conjugate is not reactive with pre-existing anti-PEG antibodies in a subject, and
wherein the molecule-polymer conjugate has reduced or eliminated antigenicity compared to a control.
US Pat. No. 10,364,196

MULTI-FUNCTIONAL COATING SYSTEM FOR CEMENTITIOUS COMPOSITE MATERIALS

James Hardie Technology L...

1. A multi-functional coating formulation for cementitious composite materials containing hydroxyl functional groups, comprising:50% to 60% by weight of a thermoplastic polymer binder comprising an epoxy ester dispersion containing at least one reactive functional group, the thermoplastic polymer binder comprising a non-crosslinking polymer capable of bonding to the hydroxyl functional groups in the cementitious composite material in a manner so as to form a sealing film on a surface of the composite material;
25% to 35% by weight of a functional pigment dispersed in the thermoplastic polymer binder, the functional pigment being rutile TiO2 having an average particle size greater than 5 microns (?m) and less than 12 microns (?m), wherein the pigment volume concentration of the rutile TiO2 in the coating formulation is about 30%, said functional pigment formulated with an oil absorption level of less than or equal to 17, wherein the oil absorption level in combination with the pigment volume concentration provide the coating formulation with blocking resistance;
10% to 20% by weight of deionized water; and
wherein the coating formulation functions as both a sealer and a primer for the cementitious composite material.
US Pat. No. 10,365,220

SINGLE-CELL RAMAN SPECTROSCOPY FOR THE NON-DESTRUCTIVE, NON-INVASIVE ANALYSIS OF CELLS AND CELLULAR COMPONENTS

LAWRENCE LIVERMORE NATION...

1. A method for non-destructively characterizing a cell, the method comprising:providing a sample comprising at least one intact cell in a solution, wherein the at least one intact cell is a white blood cell;
optically trapping a single intact cell from the sample using a laser using an excitation wavelength selected from the group of about 800-1800 nm, 780-950 nm, and 780-800 nm, wherein the excitation wavelength is selected to minimize the deleterious effects of heating the single intact cell;
illuminating the single intact trapped cell with the laser to generate a Raman spectrum, wherein the laser is not deleterious to the single intact trapped cell;
analyzing the Raman spectrum to characterize the single intact trapped cell;
identifying the single intact trapped cell as normal or abnormal based on the analyzed Raman spectrum; and
if the single intact trapped cell is identified as abnormal, removing the trapped intact abnormal cell from the sample using the laser.
US Pat. No. 10,364,453

DETECTING OF BACTERIA USING FLUORESCENTLY-LABELED PHAGE IMMOBILIZED ON AN OPTICALLY TRANSPARENT SURFACE

The United States of Amer...

1. A method for detecting bacteria in a sample, said method comprising the steps of:A) selecting a phage that is known to react with said bacteria to be detected said phage having nucleic acid;
B) immobilizing said phage head down on a transparent substrate;
C) tagging said phage nucleic acid with a fluorescent nucleic acid tag;
D) illuminating said phage from said step C) with a light source;
E) establishing a baseline fluorescence intensity for said illuminated phage from said step D);
F) exposing said tagged phage from said step C) to said sample to allow said tagged phage to lyse said bacteria;
F1) removing said substrate from said step F) from said sample;
G) illuminating said substrate from said removing step to establish a test fluorescence intensity;
H) comparing said test fluorescence intensity to said baseline fluorescence intensity, and,
I) deeming said bacteria to be present in said sample when said test fluorescence intensity is less than said baseline fluorescence intensity.
US Pat. No. 10,364,198

HEAVY PETROLEUM RESIDUE DERIVED IRON INCORPORATED SP2 CARBON NANOGRANULES FOR IMPROVED SYNTHESIS OF LIGHT OLEFINS

1. An Iron incorporated sp2 carbon nanogranules (Fe/CNG) catalyst comprising:(a) iron in the form of Fe(0), in bulk phase,
(b) iron in the form of Fe(0) along with Fe3C phase; and
(c) trace amounts of Fe(II) and Fe(III),wherein (a), (b) and (c) are collectively present in the range from 5 to 20 w/w % of the sp2 carbon nanogranules, and wherein the trace amounts of Fe(II) and Fe(III) are found on a surface of the sp2 carbon nanogranules.
US Pat. No. 10,364,205

METHOD FOR PRODUCING KETONE AND/OR ALCOHOL, AND SYSTEM THEREOF

UBE INDUSTRIES, LTD., Ub...

1. A method for producing a ketone and/or alcohol by decomposing a hydroperoxide and an ester compound in an oxidation reaction solution obtained from oxidizing a hydrocarbon compound with molecular oxygen, in which the ketone and/or alcohol has the same number of carbon atoms as the hydrocarbon compound; wherein the method comprises:neutralizing at least a part of a carboxylic acid in the oxidation reaction solution by contacting the oxidation reaction solution with a first alkaline solution comprising a carbonate of an alkali metal, and separating the reaction mixture into a first oil phase and a first water phase, wherein a content of the hydroperoxide in the first oil phase is more than 90% of a content of the hydroperoxide in the oxidation reaction solution, and a pH of the first water phase is 8.5 or more and 9.55 or less;
decomposing the hydroperoxide and the ester compound in the first oil phase by contacting the first oil phase with a second alkaline solution having a higher pH value than the first alkaline solution, and separating the reaction mixture into a second oil phase and a second water phase, wherein a pH of the second water phase is greater than or equal to the pKa of the hydroperoxide and 14.0 or less;
recovering at least a part of an unreacted hydrocarbon from the second oil phase;
obtaining the ketone and/or alcohol from the second oil phase after recovering at least a part of the unreacted hydrocarbon by purification;
recycling a part or all of the second water phase as a part of the first alkaline solution; and
recovering the carbonate of an alkali metal from the first water phase and recycling the carbonate of an alkali metal to the first alkaline solution.
US Pat. No. 10,364,207

PROCESSES FOR OBTAINING MICROBIAL OIL FROM MICROBIAL CELLS

DSM IP Assets B.V., Te H...

1. A process for obtaining a microbial oil comprising one or more polyunsaturated fatty acids from one or more microbial cells, wherein the process comprises:(a) lysing the cells comprising the microbial oil to form a lysed cell composition;
(b) demulsifying the lysed cell composition to form a demulsified lysed cell composition;
(c) separating the oil from the demulsified lysed cell composition; and
(d) recovering the oil;
wherein (b) comprises adding at least one enzyme selected from the group consisting of beta-glucanase, xylanase, cellulase, pectinase, mannanase, amylase, and combinations thereof, and wherein at least one of (a) or (b) further comprises heating the cells or the composition to at least 60° C.
US Pat. No. 10,364,208

OXIDATIVE COUPLING OF ARYL BORON REAGENTS WITH SP3-CARBON NUCLEOPHILES, AND AMBIENT DECARBOXYLATIVE ARYLATION OF MALONATE HALF-ESTERS VIA OXIDATIVE CATALYSIS

The Governors of the Univ...

1. A method for decarboxylative carbonyl ?-arylation, comprising: reactinga. an aryl coupling partner,
b. a beta-carbonyl carboxylic acid, and
c. a copper based catalyst
the reaction taking place at room temperature, exposed to air, thereby creating a carbon-carbon bond.
US Pat. No. 10,364,465

REAGENTS AND METHODS FOR SEQUENCING

Life Technologies Corpora...

1. A single nucleic acid molecule comprising at least one reference sequence and multiple variants of the at least one reference sequence,wherein the nucleotide sequences of the at least one reference sequence and each variant are defined,
wherein the at least one reference sequence and variants are arranged within the single nucleic acid molecule as cassettes,
wherein within each cassette the at least one reference sequence is operably linked to one or more of a restriction enzyme site(s), and/or hairpin-forming site(s),
wherein each variant is at least 50% identical to the reference sequence, and wherein the single nucleic acid molecule comprises at least 15 variants.
US Pat. No. 10,363,700

BIORIENTED POLYETHYLENE FILM

Dow Global Technologies L...

1. A process for forming a biaxially oriented film comprising the steps of:a. selecting a polyolefin resin, wherein said polyolefin resin comprises a linear low density polyethylene resin characterized by having from 9 to 35 weight percent of the total weight of the linear low density polyethylene resin eluting from a crystallization elution fractionation (CEF) at a temperature greater than 97.0° C., a comonomer distribution ratio (CDR) of from 33 to 80, and a molecular weight ratio (Mw Ratio) of from 0.15 to 0.45;
b. forming a film from the polyolefin resin selected in step (a); and
c. biaxially orienting the film formed in step (b),
wherein the resulting film after said orienting in step (c) is characterized by having an ultimate elongation which is at least 1.5 times greater in the machine direction (MD) of the film as compared to the cross direction (CD) of the film and a 2% secant modulus of at least 1.25 times greater in the CD as compared to the MD,
wherein the resulting film after said orienting in step (c) is further characterized by having free residual shrinkage of less than 10% in the MD and less than 10% in the CD when exposed to a temperature of 90° C. for 10 minutes,
and wherein the polyolefin resin selected in step (a) permits use of applied temperature and stretching ratio conditions for said orientation step (c) to be chosen within a relatively broad range during the orienting process without a substantial loss in quality of the bioriented film, as compared to a film formed with a polyethylene resin which does not have the CEF, CDR, and Mw Ratio parameters of the polyolefin resin selected in step (a).
US Pat. No. 10,364,469

GENE EXPRESSION PANEL FOR PROGNOSIS OF PROSTATE CANCER RECURRENCE

ILLUMINA, INC, San Diego...

1. A method for treating a patient with prostate cancer, the method comprising:obtaining a biological sample from the patient, wherein the biological sample comprises a prostate tissue sample,
detecting expression levels of a collection of genes from the biological sample, wherein detecting expression levels of the collection of genes comprises hybridizing probes specific for each of the genes to nucleic acid molecules derived from the biological sample, wherein the collection of genes comprises a collection of signature genes, and
wherein said collection of signature genes comprises NKX2-1 and ABCC11;
correlating expression levels of said collection of signature genes with prostate-cancer related mortality to identify whether the patient is at risk of prostate-cancer related mortality; and
treating a patient at risk of prostate-cancer related mortality with one or more of radical prostatectomy, brachytherapy of the prostate, radiotherapy of the prostate, neoadjuvant hormone therapy for treating prostate cancer, and adjuvant hormone therapy for treating prostate cancer.
US Pat. No. 10,364,214

METHOD FOR PRODUCING ISOCYANATES

Covestro Deutschland AG, ...

15. A plant (10 000) for preparation of an isocyanate (1) by phosgenation of the corresponding amine (2), comprising:0) optionally an apparatus (4000) for production of phosgene (3) by reaction of carbon monoxide (300) with chlorine (310), giving an offgas stream (320) comprising carbon monoxide and phosgene;
I) a reaction zone (1000) comprising a reaction space (1200) for performance of the phosgenation, with a separation unit (1210) optionally connected downstream thereof, where the reaction space or the separation unit are provided with outlet conduits for a liquid stream (60) and a gaseous stream (70);
II) a distillation apparatus (2100) for separating the liquid stream (60) into a liquid stream (80) and a gaseous stream (90);
III) optionally a distillation apparatus (2200) for separating the liquid stream (80) into a gaseous stream (110) and a liquid stream (100);
IV) optionally a distillation apparatus (2300) for separating the gaseous stream (110), optionally after its liquefaction in a condenser (2310), into a liquid stream (120) and a gaseous stream (130);
V) optionally a distillation apparatus (2400) for obtaining a liquid isocyanate stream (140) from the liquid stream (100), resulting in a gaseous stream (150) comprising secondary components and optionally solvent, optionally comprising an upstream unit for polymer removal (2410) for removal of polymeric isocyanate fractions (141);
VI) an apparatus for absorption (2500) of the gaseous streams (70) and (90) and, if present, of the gaseous stream (130), optionally after passing through units (2510) for condensation connected upstream of the apparatus for absorption (2500), in solvent (4) to obtain a liquid stream (160) and a gaseous stream (170);
VII) an apparatus for absorption (2600) of the gaseous stream (170) in water or hydrochloric acid, optionally comprising a vapor condenser (2610), to obtain a stream (190) comprising hydrochloric acid and optionally solvent and a gaseous stream (200) comprising solvent and optionally gaseous secondary components;
VIII) an apparatus for workup of offgas streams (3000), comprising
VIII-1) an apparatus for catalytic phosgene decomposition (3010) for the decomposition of phosgene present in stream (200) and optionally also for the decomposition of phosgene present in stream (320) to obtain a gaseous stream (210) comprising solvent and optionally gaseous secondary components;
VIII-2) an adsorption apparatus (3020) for adsorption of solvent from stream (210), wherein the adsorption apparatus (3020) comprises at least two adsorption units (3021, 3022) connected in parallel, which are configured such that they can alternately be
(i) charged with stream (210) and
(ii) regenerated with steam;
IX) an apparatus for offgas combustion (6000) for combustion of the gas stream (220) obtained in VIII-2) (i); and
X) units for recycling of solvent desorbed in process stage VIII-2) (ii) into the reaction zone (1000) and/or into the apparatus for absorption (2500).
US Pat. No. 10,364,470

LONG NON-CODING RNA EXPRESSED IN AGGRESSIVE CANCER

The Regents of the Univer...

7. A method of detecting the level of expression of an RNA version of the SAILOR sequence SEQ ID NO: 2 in a human tissue sample, wherein the method comprises performing a quantitative reverse transcriptase-PCR (RT-PCR) on RNA obtained from the human tissue sample using amplification oligonucleotides that amplify a fragment comprising at least 700 contiguous nucleotides of SEQ ID NO: 2.
US Pat. No. 10,364,472

METHOD FOR IDENTIFYING WUZHISHAN MINIATURE PIG INBRED LINE BY USING 145 SNPS

1. A method for auxiliarily identifying whether a pig is Wuzhishan miniature pig inbred line, comprising:a) obtaining a DNA sample from the pig;
b) testing a genotype of the pig by hybridizing the DNA sample with each of 145 probes and terminally extending each of the hybridized 145 probes; and
c) identifying the pig to be a candidate for Wuzhishan miniature pig inbred line based on 145 SNP sites if all standards of the following (1) to (145) are satisfied
(1) M1GA0025062 the genotype of SNP site is GG;
(2) DRGA0017627 the genotype of SNP site is GG;
(3) H3GA0056137 the genotype of SNP site is CC;
(4) MARC0039661 the genotype of SNP site is AA;
(5) ASGA0085025 the genotype of SNP site is TT;
(6) ASGA0098570 the genotype of SNP site is GG;
(7) MARC0063358 the genotype of SNP site is AA;
(8) ASGA0085437 the genotype of SNP site is GG;
(9) MARC0096709 the genotype of SNP site is CC;
(10) H3GA0052387 the genotype of SNP site is GG;
(11) ASGA0000264 the genotype of SNP site is TT;
(12) ALGA0000195 the genotype of SNP site is TT;
(13) H3GA0001444 the genotype of SNP site is AA;
(14) ASGA0002293 the genotype of SNP site is CC;
(15) INRA0001752 the genotype of SNP site is GG;
(16) H3GA0001445 the genotype of SNP site is GG;
(17) ALGA0002595 the genotype of SNP site is TT;
(18) ALGA0002600 the genotype of SNP site is GG;
(19) DRGA0000563 the genotype of SNP site is CC;
(20) DRGA0000565 the genotype of SNP site is CC;
(21) INRA0001761 the genotype of SNP site is AA;
(22) MARC0104045 the genotype of SNP site is CC;
(23) ALGA0002601 the genotype of SNP site is CC;
(24) DRGA0000569 the genotype of SNP site is AA;
(25) ALGA0002608 the genotype of SNP site is TT;
(26) DRGA0000568 the genotype of SNP site is CC;
(27) ALGA0002604 the genotype of SNP site is GG;
(28) MARC0048118 the genotype of SNP site is TT;
(29) ASGA0004229 the genotype of SNP site is CC;
(30) MARC0007088 the genotype of SNP site is CC;
(31) MARC0000061 the genotype of SNP site is GG;
(32) MARC0094747 the genotype of SNP site is AA;
(33) MARC0007969 the genotype of SNP site is AA;
(34) ASGA0106092 the genotype of SNP site is CC;
(35) ALGA0119806 the genotype of SNP site is GG;
(36) INRA0003745 the genotype of SNP site is AA;
(37) INRA0003746 the genotype of SNP site is TT;
(38) ALGA0005490 the genotype of SNP site is CC;
(39) H3GA0002538 the genotype of SNP site is CC;
(40) INRA0003749 the genotype of SNP site is CC;
(41) H3GA0002539 the genotype of SNP site is GG;
(42) M1GA0001099 the genotype of SNP site is CC;
(43) MARC0111831 the genotype of SNP site is AA;
(44) ASGA0005566 the genotype of SNP site is CC;
(45) ALGA0007578 the genotype of SNP site is CC;
(46) ASGA0005568 the genotype of SNP site is CC;
(47) INRA0005765 the genotype of SNP site is AA;
(48) MARC0095347 the genotype of SNP site is CC;
(49) MARC0039015 the genotype of SNP site is CC;
(50) DRGA0001892 the genotype of SNP site is GG;
(51) ALGA0007580 the genotype of SNP site is GG;
(52) ALGA0007583 the genotype of SNP site is TT;
(53) MARC0095915 the genotype of SNP site is CC;
(54) ASGA0005571 the genotype of SNP site is AA;
(55) MARC0014134 the genotype of SNP site is AA;
(56) MARC0024233 the genotype of SNP site is AA;
(57) H3GA0003548 the genotype of SNP site is GG;
(58) ALGA0007591 the genotype of SNP site is CC;
(59) MARC0000195 the genotype of SNP site is CC;
(60) ALGA0038697 the genotype of SNP site is CC;
(61) H3GA0020000 the genotype of SNP site is CC;
(62) ALGA0038703 the genotype of SNP site is CC;
(63) H3GA0020002 the genotype of SNP site is GG;
(64) DRGA0007138 the genotype of SNP site is CC;
(65) ASGA0031284 the genotype of SNP site is CC;
(66) ASGA0031285 the genotype of SNP site is AA;
(67) MARC0025042 the genotype of SNP site is GG;
(68) H3GA0020006 the genotype of SNP site is TT;
(69) ALGA0038729 the genotype of SNP site is CC;
(70) ALGA0038731 the genotype of SNP site is GG;
(71) ASGA0031321 the genotype of SNP site is GG;
(72) ASGA0031322 the genotype of SNP site is GG;
(73) ALGA0038747 the genotype of SNP site is AA;
(74) ASGA0033095 the genotype of SNP site is TT;
(75) ALGA0040854 the genotype of SNP site is GG;
(76) ALGA0040856 the genotype of SNP site is AA;
(77) ALGA0040857 the genotype of SNP site is GG;
(78) ASGA0033096 the genotype of SNP site is GG;
(79) INRA0025180 the genotype of SNP site is AA;
(80) ALGA0040859 the genotype of SNP site is CC;
(81) H3GA0021216 the genotype of SNP site is CC;
(82) ASGA0033098 the genotype of SNP site is CC;
(83) H3GA0021221 the genotype of SNP site is CC;
(84) MARC0014540 the genotype of SNP site is CC;
(85) ASGA0033103 the genotype of SNP site is CC;
(86) DIAS0000557 the genotype of SNP site is AA;
(87) ASGA0033116 the genotype of SNP site is AA;
(88) ASGA0036835 the genotype of SNP site is CC;
(89) MARC0031932 the genotype of SNP site is CC;
(90) ASGA0036838 the genotype of SNP site is CC;
(91) H3GA0023523 the genotype of SNP site is GG;
(92) ALGA0045460 the genotype of SNP site is TT;
(93) MARC0005927 the genotype of SNP site is GG;
(94) MARC0005928 the genotype of SNP site is AA;
(95) ASGA0036842 the genotype of SNP site is CC;
(96) ASGA0036846 the genotype of SNP site is CC;
(97) MARC0098637 the genotype of SNP site is TT;
(98) M1GA0011035 the genotype of SNP site is TT;
(99) DRGA0008230 the genotype of SNP site is GG;
(100) ASGA0036855 the genotype of SNP site is CC;
(101) ALGA0097277 the genotype of SNP site is GG;
(102) MARC0080197 the genotype of SNP site is CC;
(103) H3GA0050489 the genotype of SNP site is TT;
(104) ALGA0097281 the genotype of SNP site is TT;
(105) H3GA0050490 the genotype of SNP site is CC;
(106) ALGA0097282 the genotype of SNP site is TT;
(107) ASGA0079089 the genotype of SNP site is CC;
(108) INRA0055354 the genotype of SNP site is GG;
(109) ASGA0079091 the genotype of SNP site is TT;
(110) ASGA0079090 the genotype of SNP site is CC;
(111) H3GA0050491 the genotype of SNP site is AA;
(112) MARC0056017 the genotype of SNP site is TT;
(113) MARC0055759 the genotype of SNP site is AA;
(114) H3GA0050495 the genotype of SNP site is GG;
(115) ALGA0097291 the genotype of SNP site is GG;
(116) ALGA0097290 the genotype of SNP site is GG;
(117) CASI0006683 the genotype of SNP site is GG;
(118) ASGA0079098 the genotype of SNP site is CC;
(119) ALGA0097297 the genotype of SNP site is GG;
(120) H3GA0054426 the genotype of SNP site is TT;
(121) ALGA0098112 the genotype of SNP site is GG;
(122) MARC0089391 the genotype of SNP site is GG;
(123) ASGA0089892 the genotype of SNP site is AA;
(124) ASGA0097792 the genotype of SNP site is CC;
(125) MARC0046857 the genotype of SNP site is GG;
(126) MARC0077194 the genotype of SNP site is AA;
(127) ALGA0108769 the genotype of SNP site is CC;
(128) H3GA0050799 the genotype of SNP site is CC;
(129) ALGA0098120 the genotype of SNP site is CC;
(130) ALGA0098123 the genotype of SNP site is GG;
(131) ALGA0098128 the genotype of SNP site is GG;
(132) ASGA0079719 the genotype of SNP site is CC;
(133) ASGA0079728 the genotype of SNP site is GG;
(134) ASGA0080429 the genotype of SNP site is CC;
(135) MARC0052755 the genotype of SNP site is GG;
(136) ALGA0098918 the genotype of SNP site is GG;
(137) ASGA0080432 the genotype of SNP site is GG;
(138) ALGA0098922 the genotype of SNP site is CC;
(139) INRA0056206 the genotype of SNP site is GG;
(140) INRA0056207 the genotype of SNP site is CC;
(141) ASGA0080435 the genotype of SNP site is CC;
(142) MARC0068495 the genotype of SNP site is GG;
(143) ASGA0080436 the genotype of SNP site is CC;
(144) MARC0003370 the genotype of SNP site is CC;
(145) ASGA0085659 the genotype of SNP site is CC;and, if any standard of the above (1) to (145) is not satisfied, the pig is a candidate for non-Wuzhishan miniature pig inbred line.
US Pat. No. 10,364,473

FAST DIAGNOSIS AND PERSONALIZED TREATMENTS FOR ACNE

THE REGENTS OF THE UNIVER...

1. A method for treating acne in a subject in need thereof, comprising: administering an effective amount of a composition comprising an RT6 strain of P. acnes to the subject.
US Pat. No. 10,364,218

METHOD OF PRODUCING EPSILON-CAPROLACTAM

Toray Industries, Inc., ...

1. A method of producing ?-caprolactam, comprising: step 1 of mixing at least one selected from the group consisting of 3-oxoadipic acid and salts thereof with a catalyst and a solvent in the presence of hydrogen to produce 3-hydroxyadipic acid; and step 2 of reacting the 3-hydroxyadipic acid which is a product of step 1, a salt or carboxylic acid derivative thereof, or a mixture thereof with hydrogen and ammonia.
US Pat. No. 10,363,708

COMPOSITION FOR PREPARING LIGHTWEIGHT TRANSPARENT COMPOSITE, METHOD OF PREPARING COMPOSITE USING THE SAME AND COMPOSITE PREPARED THEREBY

HYUNDAI MOTOR COMPANY, S...

1. A composition for preparing a lightweight transparent composite, comprising:(A) a glass fiber reinforcement having a refractive index of 1.4 to 1.6;
(B) a curable resin having a deviation in refractive index of ?0.005 to +0.005 from the glass fiber reinforcement (A); and
(C) a ruthenium-based catalyst which is a ruthenium metal-based metathesis catalyst comprising at least one selected from the group consisting of molybdenum (Mo), tungsten (W), and osmium (Os).
US Pat. No. 10,364,220

SYNTHESIS OF SUCCINIMIDES AND QUATERNARY AMMONIUM IONS FOR USE IN MAKING MOLECULAR SIEVES

ExxonMobil Chemical Paten...


US Pat. No. 10,363,459

GOLF BALL

SUMITOMO RUBBER INDUSTRIE...

1. A golf ball comprising a spherical core and one or more cover layers disposed outside the spherical core, wherein at least one layer of the cover layers contains:(A) a base resin containing (a-1) an ionomer resin and having a material hardness of 58 or less in Shore D hardness; and
(B) a polyrotaxane having a cyclodextrin with at least a part of hydroxyl groups of the cyclodextrin being modified with a caprolactone chain via —O—C3H6—O— group, a linear molecule piercing through a cyclic structure of the cyclodextrin, and blocking groups located at both terminals of the linear molecule to prevent disassociation of the cyclodextrin.
US Pat. No. 10,364,483

HIGH HARDNESS, HIGH ELASTICITY INTERMETALLIC COMPOUNDS FOR MECHANICAL COMPONENTS

The United States of Amer...

1. A material comprising:54-57 atomic percent nickel (Ni);
0.1 up to and including 27 atomic percent of the sum of one or more elements from the group consisting of zirconium (Zr), hafnium (Hf), rutherfordium (Rf), lanthanum (La), and tantalum (Ta); and
a balance of the material being titanium (Ti) by atomic percent, wherein the material has a lower solvus temperature than that of 60-NITINOL, wherein the material possesses a hardness between 56 and 62 on the Rockwell C (HRC) hardness scale.
US Pat. No. 10,363,206

ORAL CARE COMPOSITIONS

Colgate-Palmolive Company...

1. An oral care composition comprising a calcium abrasive, potassium nitrate (KNO3), and a basic amino acid, in free or salt form, wherein the potassium nitrate is present in an amount of 0.3-0.8% by weight of the composition, wherein the composition is a dentifrice, wherein the calcium abrasive is present in an amount of 30-60% by weight of the composition, wherein the basic amino acid, in free or salt form, is present in an amount of 0.1-20% by weight of the composition, wherein the calcium abrasive is calcium carbonate, and wherein the basic amino acid, in free or salt form, is arginine, in free or salt form.
US Pat. No. 10,363,208

METHODS FOR IMPROVING THE DURABILITY OF COLOR IN ARTIFICIALLY COLORED HAIR

1. A method for artificially coloring hair and inhibiting the coloring from fading, the method comprising:(a) treating hair with a pre-color treatment composition comprising about 0.1 wt. % to about 50 wt. % of one or more divalent metal salts of an inorganic acid and about 0.1 wt. % to about 50 wt. % of one or more monovalent or divalent metal salts of an organic acid; and
(b) treating the hair with a hair coloring composition comprising one or more colorants chosen from oxidative dye precursors, direct dyes, pigments, and mixtures thereof,
wherein the weight ratio of the one or more divalent metal salts of an inorganic acid to the one or more monovalent or divalent metal salts of an organic acid is from about 10:1 to about 1:10, and
all weights being based on the total weight of the pre-color treatment composition.
US Pat. No. 10,363,209

COSMETIC COMPOSITION

Conopco, Inc., Englewood...

1. A cosmetic composition comprising particles dispersed in a cosmetically acceptable carrier,wherein the particles comprise polymer, redox dye and reducing agent;
wherein the cosmetically acceptable carrier is a water and oil emulsion;
wherein the particles are dispersed in the oil phase of the water and oil emulsion;
wherein from 50 to 100% by weight of the particles have a particle size of from 1 to 20 ?m;
wherein the particles comprise polymer in an amount of at least about 80 to 98% by weight of the particles; and
wherein the cosmetic composition comprises the particles in an amount of at least 2% and less than 7%.
US Pat. No. 10,363,210

ORAL CARE COMPOSITIONS

Colgate-Palmolive Company...

1. A toothpaste composition comprising:(i) a whitening complex comprising crosslinked polyvinylpyrrolidone complexed with hydrogen peroxide, wherein the whitening complex contains about 10-30% hydrogen peroxide, by weight, and about 5-15% total nitrogen by weight, and
(ii) 25-40% by weight of humectants selected from propylene glycol, glycerin, and combinations thereof;
(iii) 5-15% by weight of polyethylene glycol of average molecular weight 400 to 800 Da;
and wherein the composition comprises 0.5 to 3% of total hydrogen peroxide by weight of the composition, and wherein the composition comprises less than 2% by weight of water; and
(iv) 25-45% by weight of a calcium abrasive.
US Pat. No. 10,363,724

RESIN COMPOSITION AND COMPRESSION-MOLDED ARTICLE OF SAME

Mitsubishi Chemical Corpo...

15. A molded article formed by compression molding the prepreg laminate according to claim 14.
US Pat. No. 10,363,213

IMMUNOGENIC COMPOSITION AGAINST CAMPYLOBACTER JEJUNI

The United States of Amer...

1. A method of inducing an immune response in a mammal against a Campylobacter jejuni strain comprising administering to said mammal an immunogenic composition comprising one or more isolated capsule polysaccharides or polysaccharide polymers derived from Campylobacter jejuni strain HS50; wherein said immunogenic composition does not contain Campylobacter jejuni lipooligosaccharide structures associated with Guillain-Barré Syndrome; wherein said immune response is against a Campylobacter jejuni strain of an HS4 complex selected from the group consisting of Campylobacter jejuni strains HS4, HS13, HS4/13/64, and HS50; wherein the structure of HS4 is [?3)-L-?-D-ido-Hep-(1?4)-?-D-GlcNAc-(1?]n, with non-stoichiometric MeOPN at C-4 of LD-ido-Hep; wherein the structure of HS4/13/64 is [?3)-6d-?-D-ido-Hep-(1?4)-?-D-GIcNAc-(1?]n with non-stoichiometric MeOPN at C-2 and/or C-7 of 6d-ido-Hep; and wherein “n” is 1 to 100.
US Pat. No. 10,363,214

METHOD FOR TREATING ATROPHIC AGE RELATED MACULAR DEGENERATION

Allergan, Inc., Irvine, ...

1. A method for treatment of dry age-related macular degeneration the method comprising the steps of:preparing a biocompatible, sustained release drug delivery system comprising between 5 ?g and 20 ?g of bevacizumab and a polymeric hyaluronic acid vehicle cross-linked or noncross-linked the bevacizumab; and
injecting the drug delivery system into the vitreous of an eye of a patient with dry AMD;
wherein the drug delivery system releases between about 14 ng to about 120 ng of bevacizumab over a 24 hour period for between about 3 months and about 6 months.
US Pat. No. 10,363,215

POROUS MICROPARTICLES WITH HIGH LOADING EFFICIENCIES

1. A method of making a double emulsion comprising:preparing by mechanical dispersion a first portion as a high internal phase emulsion, the first portion as the high internal phase emulsion comprising at least one biodegradable polymeric material and at least one cross-linking agent in an organic phase, and further comprising a chemical to prevent Ostwald ripening in an aqueous phase; and
adding drop wise the first portion in a second portion to form a porous microparticle-like composition, the second portion being in an aqueous phase,
wherein the aqueous phase of the first portion is encapsulated in the porous microparticle-like composition,
wherein the biodegradable polymeric material comprises:
a macromer having at least one end group selected from one or more of an acrylate and a methacrylate;
one or more linkages in the macromer, the one or more linkages selected from one or more of an anhydride and an ester,
wherein the biodegradable polymeric material has an octanol-water partition coefficient of between about 2 and about 8,
wherein the biodegradable polymeric material has a viscosity of between about 0.08 cP and about 1000 cP;
wherein the porous microparticle-like composition includes a porous region containing at least one substance selected to be one or more of compatible with a biologic system, and active in a biologic system,
wherein the porous microparticle-like composition has a spherical shape and a cross sectional diameter that is of a generally uniform size, the cross-sectional diameter in a range from between about 20 micrometers and about 1000 micrometers, with a standard deviation that is not more than 50 micrometers when the cross-sectional diameter is greater than 300 micrometers, and
wherein the first portion and the second portion are solvent free.
US Pat. No. 10,363,733

PHOTOSENSITIVE RESIN COMPOSITION, PLANOGRAPHIC PRINTING PLATE PRECURSOR, METHOD FOR PRODUCING PLANOGRAPHIC PRINTING PLATE, AND POLYMER COMPOUND

FUJIFILM CORPORATION, To...

1. A positive type lithographic printing plate precursor comprising:a recording layer which contains a photosensitive resin composition on a support having a hydrophilic surface,
wherein the photosensitive resin composition comprises:
a polymer compound which has an amine bond or a quaternary ammonium salt bond in the main chain, and at least one bond selected from the group consisting of a urea bond, a urethane bond, and a carbonate bond in the main chain and has a sulfonamide group or a phenolic hydroxyl group in the main chain and/or the side chain; and
an infrared absorbing material.
US Pat. No. 10,365,269

SYSTEM AND METHODS FOR DETECTING RIBOSOME INHIBITION

1. A method of measuring ribosome inhibition, the method comprising:providing a genetically-modified cell comprising:
an aminoglycoside-sensitive orthogonal 16S rRNA (O-16S) coding region bearing a mutated anti-Shine-Dalgarno (O-ASD) sequence;
a repressor/operator pair that comprises:
a coding region that encodes a transcriptional regulator and having an orthogonal SD (O-SD) sequence complementary to the 16S rRNA O-ASD sequence; and
an operator sequence repressable by the transcriptional regulator; and
a polynucleotide encoding a detectable reporter operably linked to the operator sequence repressable by the transcriptional regulator;
contacting the cell with a test compound; and
detecting a signal produced by the reporter, wherein intensity of the signal indicates a dose dependent degree of ribosome inhibition.
US Pat. No. 10,365,271

LIGHT HARVESTING MULTICHROMOPHORE COMPOSITIONS AND METHODS OF USING THE SAME

The Regents of the Univer...

1. An aqueous composition comprising an aggregate of light harvesting multichromophore conjugated polymers in an aqueous solution that are configured upon excitation to transfer energy to, and amplify the emission from, an acceptor signaling chromophore in energy-receiving proximity therewith in the aqueous solution, wherein the light harvesting multichromophore conjugated polymers comprise water soluble groups and are linked to a sensor biomolecule that specifically binds a target.
US Pat. No. 10,363,225

NON-BLEEDING BIOACTIVE NATURAL PIGMENTS WHICH PREVENT COLOR AND DUST EXPLOSIONS, METHOD OF PREPARATION THEREOF

1. A Non-bleeding curcumin (NBC) consisting of curcumin and a coating of polymer, whereinthe polymer is selected from the group consisting of hydroxypropyl methylcellulose, hydroxypropyl cellulose, polyvinyl alcohol and mixtures thereof;
the NBC contains concentration of curcuminoids not less than 90% (w/w) and up to 95% (w/w) measured by HPLC, which is substantially equivalent to standard curcumin with 95% purity;
the NBC having the particle size distribution in the range of 180 to 2000 microns;
the NBC retains radical scavenging property, biological activity, flavor, and color of said standard curcumin;
and the polymer prevents color leakage, bleeding, staining or dusting during industrial processing of said curcumin.
US Pat. No. 10,363,229

METHODS AND COMPOSITIONS FOR THE TREATMENT OF CANCER

1. A method for treating a metastatic cancer in a subject having the metastatic cancer comprising administering to the subject a therapeutically effective amount of methyl sulfone, thereby treating the cancer, wherein the therapeutically effective amount comprises a solution of methyl sulfone in the range of 0.2 to 0.6 mg methyl sulfone/ml solvent, or 1.0 to 5.0 mg methyl sulfone/ml solvent, and wherein administration of the methyl sulfone to the subject induces cells of the cancer to revert to a normal cellular phenotype from a cancer cell phenotype.
US Pat. No. 10,365,279

ASSAY SYSTEM FOR THE ASSESSMENT OF ONCOGENICITY, TUMOR PROGRESSION, AND TREATMENT EFFICACY

Berg LLC, Framingham, MA...

1. A method for diagnosing and treating cancer in a subject, comprising:(i) detecting in a tissue sample obtained from a suspected lesion of abnormal growth from the subject a decrease in total cellular protein level of Cytochrome C and proteins implicated in apoptosis comprising Bax, p53, Bid, and Caspase-3, based on comparison with a baseline value of the proteins;
(ii) detecting in the tissue sample an increase in total cellular protein level of two or more proteins implicated in angiogenesis, wherein the proteins are selected from the group consisting of VEGF, HIF-1?, and bFGF, based on comparison with a baseline value of the proteins;
(iii) determining that the tissue sample is cancerous, exhibits angiogenesis indicative of an aggressive cancer, and exhibits significant apoptotic resistance to chemotherapy treatment; and
(iv) administering a non-chemotherapy or anti-angiogenic cancer treatment to the subject based on the determination in step (iii).
US Pat. No. 10,366,568

LOTTERY GAME PROVIDING A CHANCE TO WIN A JACKPOT AT A REDUCED COST TO THE PLAYER, WITH AN INCREASED REVENUE TO THE OPERATOR AND TICKET RETAILER

1. A method of playing a game of chance comprising:providing a Player an entry recorded on a printed ticket to said game of chance from a Ticket Retailer, said game of chance comprising a prize structure, said prize structure comprising a jackpot and a plurality of lesser prizes, wherein said entry provides a chance to win said jackpot and a reduced subset or no subset of said plurality of lesser prizes,
wherein said entry is printed on said ticket by a computer system configured to generate the entry based on random generation of the entry or user input and to print the entry on the printed ticket,
and wherein the entry is purchased at a reduced cost as compared to an entry with a chance to win all available prizes in the game of chance.
US Pat. No. 10,363,245

METHODS FOR TREATING CNS LESIONS

THE BOARD OF REGENTS OF T...

1. A method of treating a brain lesion in a subject diagnosed with multiple sclerosis (MS) comprising orally administering a carbonic anhydrase inhibitor to the subject in an effective amount to increase cerebral perfusion.