US Pat. No. 10,335,260

METHODS OF TREATING A THROMBUS IN A VEIN USING CYCLICAL ASPIRATION PATTERNS

Insera Therapeutics, Inc....

1. A method of treating a thrombus in a vein using a repetitive cyclical pattern for aspiration, the method comprising:inserting a distal end of a catheter into the vein, wherein the thrombus is distal to the distal end of the catheter, wherein the thrombus causes acute ischemic stroke due to cerebral venous sinus thrombosis or causes deep vein thrombosis;
choosing the cyclical pattern from a plurality of provided cyclical patterns, the cyclical pattern comprising repetition of a first suction level, a second suction level different than the first suction level, and a third suction level different than the first suction level and the second suction level; and
aspirating the thrombus using negative pressure through the catheter, the negative pressure varying according to the chosen cyclical pattern generated by power electronics of an automated negative suction device.

US Pat. No. 10,335,257

THREE-DIMENSIONAL RESORBABLE IMPLANTS FOR TISSUE REINFORCEMENT AND HERNIA REPAIR

Tepha, Inc., Lexington, ...

1. A reinforced absorbable implant comprising:a) a three-dimensional structure comprising an original three dimensional shape comprising a concave and a convex surface configured to contour to a patient's tissue, and monofilament, multifilament fibers or combinations thereof comprising poly-4-hydroxybutyrate (P4HB) or a copolymer thereof, or a porous film comprising P4HB or a copolymer thereof, and
b) a reinforcing material comprising a continuous or interrupted ring of P4HB extrudate at the outlying border of the three-dimensional structure, wherein the implant can be temporarily deformed for implantation and the three dimensional structure unaided assumes its original three-dimensional shape,
wherein the implant has one or more of the following properties:
(i) a suture pullout strength of at least 10 N
(ii) a burst strength of at least 1 Kg;
(iii) pore diameters of at least 50 ?m; and
(iv) a Taber stiffness that is less than 100 Taber stiffness units.

US Pat. No. 10,335,256

SURGICAL ARTICLES AND METHODS FOR TREATING PELVIC CONDITIONS

Boston Scientific Scimed,...

1. A method of supporting a tissue of a pelvic floor, the method comprising:creating an incision that allows access to a region of the pelvic floor;
providing a pelvic implant including a tissue support portion, a first extension portion, and a second extension portion, the tissue support portion including a first side end and a second side end opposite the first side end, the first side end having a first length and the second side end having a second length, the second length being different than the first length, the first extension portion and the second extension portion being integrally formed with the tissue support portion, a first anchor disposed at the first extension portion and a second anchor disposed at the second extension portion, a third length between the first extension portion and the second extension portion defining a third side end, the third side end being at an angle with respect to at least one of the first side end or the second side end, the pelvic implant having a width at a medial portion of the tissue support portion, the third length being larger than the width;
adjusting a length of the first extension portion to allow a distal end of the first anchor to reach a desired tissue within or external to the pelvic floor;
passing the pelvic implant through the incision and placing the tissue support portion at the tissue of the pelvic floor; and
positioning the tissue support portion at the region of the pelvic floor to support the tissue of the pelvic floor.

US Pat. No. 10,335,255

STRAW FOR THE PRESERVATION OF A PREDETERMINED DOSE OF LIQUID-BASED SUBSTANCE, IN PARTICULAR A BIOLOGICAL SUBSTANCE

IMV TECHNOLOGIES, Saint ...

1. A straw for preservation of a predetermined dose of liquid-based substance containing water, comprising a tube configured to be filled with the liquid-based substance, the liquid-based substance being a biological substance, the tube extending between a first end and a second end and further comprising a liquid-tight, gas-permeable stopper, the stopper being disposed in the tube close to a first end of the tube and extending between a first end turned towards the first end of the tube and a second end turned towards the second end of the tube, said stopper and said tube being configured so that after the liquid-based substance has come to meet the stopper by the second end of the stopper, the stopper blocks passage of the liquid-based substance and, by pushing on the first end of the stopper, the stopper is slidable in the tube towards the second end of the tube;wherein the stopper comprises towards the second end of the tube a barrier plug formed over the whole cross-section of the tube by hydrophobic threads, the barrier plug being configured to allow the liquid-based biological substance to pass therethrough while filling the tube but to be repelled by the barrier plug while passage of the liquid-based substance is blocked by the stopper.

US Pat. No. 10,335,251

ORTHODONTIC DIGITAL SETUPS

3M INNOVATIVE PROPERTIES ...

1. A computer-implemented method of simulating a collision between a first virtual tooth and a second virtual tooth comprising:receiving into the computer digital data defining, in three-dimensional space, the first virtual tooth and the second virtual tooth;
receiving permissible movement input data directed to permissible movement of the first virtual tooth along or about a first axis;
using the computer's processor, simulating, in three-dimensional space, bringing the first virtual tooth into contact with the second virtual tooth while constraining movement of the first virtual tooth based on the permissible movement input data, further comprising accompanying the movement of the first virtual tooth with an automatic movement that forces the first virtual tooth along or about an axis different from the first axis until the first virtual tooth contacts one or more neighboring teeth; and
displaying, in a user interface of a display, data resulting from the simulation.

US Pat. No. 10,335,247

UNIVERSAL INSTRUMENT OR INSTRUMENT SET FOR COMPUTER GUIDED SURGERY

Brainlab AG, Munich (DE)...

1. A reference element adapter apparatus rotatably attachable with a shaft of an associated instrument for use in computer guided surgery, the reference element adapter apparatus comprising:a body member comprising a portion configured for selective attachment with an associated reference element, the body member defining an inner axial passageway having a fixed inner diameter,
wherein the body member is selectively coaxially receivable directly and rotatably on an instrument shaft adapting interface of the shaft of the associated instrument at the fixed inner diameter to provide relative rotatable attachment between the associated instrument and the associated reference element selectively attached with the body member, the reference element adapter apparatus further comprising a mechanical retainer operable to provide selective retention of the instrument shaft of the associated instrument relative to the body member, wherein the mechanical retainer comprises a catch providing a surmountable frictional or positive coupling between the body member and the instrument shaft of the associated instrument, wherein the catch comprises:
a ball-thrust piece configured to engage a plurality of associated longitudinal notches on the instrument shaft of the associated instrument to inhibit rotation between the body member and the instrument shaft of the associated instrument, or
a plurality of circumferentially distributed longitudinal notches defined on the inner axial passageway, the plurality of circumferentially distributed longitudinal notches being configured to receive an associated ball-thrust piece carried on the instrument shaft of the associated instrument to inhibit the rotation between the body member and the instrument shaft of the associated instrument.

US Pat. No. 10,335,245

PACKAGING, PACKAGING ASSEMBLY, AND METHOD FOR USING THE SAME

OSSUR ICELAND EHF, Reykj...

18. A packaging assembly containing an article comprising at least first and second functional features and secured at a predetermined location relative to the packaging assembly in closed and open configurations of the packaging assembly, the packaging assembly comprising:at least two sections arranged to be secured in place relative to one another in the closed configuration, and move relative to one another in the open configuration, the at least two sections forming an inner surface defining an attachment area upon which the article is secured;
at least one instruction area located along the inner surface and having indicia comprising at least first and second indicators pointing to the at least first and second functional features of the article, respectively, for placement in the packaging assembly, the at least one instruction area being located relative to an attachment area displayed by the at least two sections and the article having a feature corresponding to and secured to the attachment area at a marking in both the closed and open configurations;
at least one closure is arranged to secure edges of the at least two sections to one another in the closed configuration;
wherein the indicia represents a sequence of steps for utilizing a sequence of the at least first and second functional features of the article;
wherein the article is secured to the at least two sections such that the article is stabilized in the open configuration of the packaging assembly in an open configuration of the article;
wherein the packaging assembly is arranged to support the article in a preconfigured condition for donning.

US Pat. No. 10,335,242

INDICATOR FOR TOOL STATE AND COMMUNICATION IN MULTI-ARM ROBOTIC TELESURGERY

Intuitive Surgical Operat...

1. A method comprising:receiving an input at a control system indicating a status change for a first tool coupled to a first manipulator assembly of a telesurgical system, wherein the status change is correlated to a procedure to decouple the first tool from the first manipulator assembly or manually reconfigure the first manipulator assembly;
transmitting a command to the first manipulator assembly; and
responsive to the transmitted command, activating a multiple-color light emitting diode (LED) array in an indicator section on the first manipulator assembly to generate a signal indicating a reconfiguration action for the first tool or the first manipulator assembly to a first user.

US Pat. No. 10,335,240

ENDOVASCULAR NAVIGATION SYSTEM AND METHOD

ARROW INTERNATIONAL, INC....

1. An endovascular navigation system, comprising:an elongate flexible member configured to access the venous vasculature of a patient;
a sensor disposed at a distal end of the elongate flexible member and configured to sense a physiological signal of the venous vasculature of the patient;
a processor configured to:
receive the physiological signal of the venous vasculature of the patient provided by the sensor;
process the physiological signal to determine one or more physiological characteristics of the venous vasculature of the patient;
track a position of the distal end of the elongate flexible member within the venous vasculature of the patient over time; and
determine, based on the one or more physiological characteristics of the venous vasculature of the patient, that the position of the distal end of the elongate flexible member is within a predetermined structure within the venous vasculature of the patient;
a display output device configured to simultaneously display:
a graphical representation of a path between tracked positions of the distal end of the elongate flexible member within the venous vasculature of the patient over time;
a first visual indication of the position of the distal end of the elongate flexible member in real time;
at least part of the physiological signal provided by the sensor over time; and
a second visual indication that the distal end of the elongate flexible member is within the predetermined structure within the venous vasculature of the patient only when it is determined that the position of the distal end of the elongate flexible member is within the predetermined structure within the venous vasculature of the patient, wherein the second visual indication is different from the physiological characteristic of the venous vasculature of the patient, and the graphical representation is different from the at least part of the physiological signal and the second visual indication; and
an audible output device configured to output an audible indication of the position of the distal end of the elongate flexible member.

US Pat. No. 10,335,232

APPARATUS FOR USING INTENSE PULSED LIGHT TO NON-INVASIVELY TREAT BLEPHARITIS, DRYEYE, CONJUNCTIVAL BLOOD VESSELS, PIGMENTED LESIONS, AND OTHER PROBLEMS OF THE EYE AND EYELID

1. An IPL system for precisely and non-invasively treating small blood vessels, small lesions, small dermatological stains, ingrown hairs, blepharitis, dry eye, and other ocular and periocular problems of a patient, including:a handpiece;
a power source;
an IPL source, including a crystal having a distal end and a handpiece end operatively connected to the handpiece;
controls for varying one or more parameters that determine the amount of IPL to be used;
wherein the handpiece is sized and configured for precise digital manipulation by an operator's fingers for applying IPL to non-corneal and periocular portions of an eye and is operatively connected to the power source, the IPL source, and the controls;
a distance guide, sized and configured to contact the non-corneal and periocular portions of the eye, and having a distal end for contact and a proximal end attached to the handpiece such that the distal end of the IPL source is located at a fixed and known distance from the distal end of the distance guide; and
an eye shield for covering a portion of the patient's eye, including the entire cornea.

US Pat. No. 10,335,230

SYSTEMS FOR THERMAL-FEEDBACK-CONTROLLED RATE OF FLUID FLOW TO FLUID-COOLED ANTENNA ASSEMBLY AND METHODS OF DIRECTING ENERGY TO TISSUE USING SAME

COVIDIEN LP, Mansfield, ...

1. A method of directing energy to tissue by using a fluid-cooled antenna assembly of an energy applicator, the method comprising:connecting the energy applicator to a hub, the hub coupled to a coolant supply system for providing fluid to the antenna assembly of the energy applicator, the coolant supply system having a coolant source, a first coolant supply line, a second coolant supply line, and a third coolant supply line in fluid communication with the coolant source, the first coolant supply line connected between the coolant source and a fluid-movement device, the second coolant supply line directly connected between a pressure transducer and the fluid-movement device, and the third coolant supply line directly connected between a flow-control device and the antenna assembly;
positioning the energy applicator in tissue;
activating the energy applicator via an electrosurgical generator;
measuring a temperature of the fluid in the antenna assembly;
controlling a thermal-feedback-controlled rate of fluid flow based on the measured temperature of the fluid in the antenna assembly;
providing fluid to the antenna assembly at the thermal-feedback-controlled rate of fluid flow using a feedback control system including the flow-control device, the flow control device including a valve and an electro-mechanical actuator, and the feedback control system including a processor unit; and
connecting the pressure transducer to the valve, the pressure transducer disposed within the coolant supply system;
wherein the pressure transducer outputs a signal at a pressure below a burst pressure of a pressure relief valve to indicate to the electrosurgical generator that the fluid-cooled antenna assembly has coolant flowing therethrough and wherein the processor unit triggers a shut-off of the electrosurgical generator based on pressure levels of the coolant in the fluid-cooled antenna assembly; and
wherein the processor unit outputs a signal indicative of an error code if a predetermined time elapses between energy delivery to the fluid-cooled antenna assembly and detection of the signal outputted by the pressure transducer.

US Pat. No. 10,335,229

VESSEL SEALING INSTRUMENT WITH SUCTION SYSTEM

COVIDIEN LP, Mansfield, ...

1. A forceps, comprising:a first elongated shaft having a first proximal portion and a first distal portion;
a second elongated shaft having a second proximal portion and a second distal portion;
a first jaw member secured to and extending from the first distal portion;
a second jaw member secured to and extending from the second distal portion, the first and second jaw members moveable about a pivot between an open position in which the first and second jaw members are spaced-apart from one another and a closed position in which the first and second jaw members cooperate to grasp tissue therebetween; and
a tube extending from the first proximal portion to the first distal portion and including a distal tube segment, the distal tube segment slidable relative to the first and second jaw members between a retracted position relative to the first and second jaw members and a deployed position relative to the first and second jaw members distal of the retracted position.

US Pat. No. 10,335,226

SURGICAL FORCEPS CAPABLE OF ADJUSTING SEALING PRESSURE BASED ON VESSEL SIZE

COVIDIEN LP, Mansfield, ...

1. A forceps, comprising:an end effector assembly including first and second jaw members disposed in opposing relation relative to one another, at least one of the first and second jaw members movable relative to the other from a first position to a plurality of second positions, the first and second jaw members configured to grasp tissue therebetween in each of the plurality of second positions, at least one of the first and second jaw members including a sensor configured to sense at least one property of tissue disposed between the first and second jaw members and determine an output based upon the at least one sensed property;
a handle assembly including a movable handle coupled to the end effector assembly, the movable handle movable between an initial position and a plurality of subsequent positions for moving the first and second jaw members between the first position and the plurality of second positions, respectively;
a processor configured to receive the output from the sensor and determine a seal pressure for adequately sealing tissue disposed between the first and second jaw members based upon the output; and
a regulator in communication with the processor and configured to receive the determined seal pressure from the processor, the regulator configured, based on the determined seal pressure received, to regulate a range of motion of the first and second jaw members between the first position and a selected one of the plurality of second positions such that movement of the first and second jaw members from the first position to the selected one of the plurality of second positions applies the determined seal pressure to tissue disposed between the first and second jaw members, the regulator disposed within the handle assembly and configured to regulate the range of motion of the first and second jaw members by limiting movement of the movable handle between the initial position and a selected one of the subsequent positions to thereby regulate the range of motion of the first and second jaw members.

US Pat. No. 10,335,225

ELECTROSURGICAL MEDICAL DEVICE HANDPIECE WITH INSULATED ASPIRATION SYSTEM

Arthrex, Inc., Naples, F...

1. An electrosurgical instrument for the treatment of tissue, comprising:a shaft;
an electrode assembly, comprising:
at least one active electrode;
at least one return electrode separated from the active electrode via at least one insulator;
the at least one insulator forming an internal aspiration collection chamber configured to received aspirated material from a surgical site and to pass the aspirated material on within the electrosurgical instrument;
wherein the internal aspiration collection chamber is in fluid communication with at least one aspiration inlet; and
an aspiration system for removing material from a surgical site, the aspiration system including at least one conduit formed by a channel extending through the shaft, the internal aspiration collection chamber and the at least one aspiration inlet;
wherein the at least one active electrode includes a support arm extending from a substantially planar outer surface of the at least one active electrode inwardly toward a longitudinal axis of the channel of the aspiration system whereby the support arm includes a threaded support orifice configured to be threadably attached to threads at a distal end of the channel of the aspiration system.

US Pat. No. 10,335,213

BONE PLATE WITH A BONE SCREW

1. An osteosynthesis device with a bone plate and with at least one bone screw, wherein the bone plate has at least one through-hole with a conical inner thread formed at least in part in the through-hole, the bone screw moreover has a screw shank and also a screw head with a conical thread, with the possibility of forming a connection at a variable and stable angle between bone screw and bone plate by receiving the screw head with conical outer thread in the respective through-hole of the bone plate,characterized in that the thread in the screw head has a first portion with a first conicity and a second portion with a second conicity, wherein a zone of discontinuity with respect to the conicity is present between the first portion and the second portion.

US Pat. No. 10,335,211

HIGHLY-VERSATILE VARIABLE-ANGLE BONE PLATE SYSTEM

DePuy Synthes Products, I...

1. A method of forming a thread in an outer surface of a head of a bone screw that is elongate along a central axis, the method comprising the steps of:orienting a thread cutter in a first orientation with respect to the bone screw, the thread cutter including a cutting bit having an apex, wherein the cutting bit extends along a longitudinal axis that normally intersects the apex of the cutting bit, and when the thread cutter is in the first orientation the longitudinal axis is perpendicular to a central axis of the bone screw;
after the orienting step, rotating the bone screw at least one complete revolution about the central axis relative to the cutting bit while 1) maintaining the thread cutter in the first orientation with respect to the bone screw; 2) maintaining contact between the cutting bit and the outer surface; and 3) translating the bone screw relative to the cutting bit with respect to the central axis a first distance per revolution; and
after the rotating step, further rotating the bone screw another at least one complete revolution about the central axis relative to the cutting bit while 1) maintaining the thread cutter in the first orientation with respect to the bone screw; 2) maintaining contact between the cutting bit and the outer surface; and 3) translating the bone screw relative to the cutting bit with respect to the central axis a second distance per revolution that is different than the first distance per revolution,
wherein both of the rotating steps result in the forming of a cross-sectional profile of the thread, the cross-sectional profile having a plurality of peaks, a plurality of troughs each of which are positioned between adjacent ones of the plurality of peaks, and a plurality of flanks each of which connect one of the plurality of peaks to an adjacent one of the plurality of troughs, each of the plurality of peaks being spaced farther from the central axis than adjacent ones of the plurality of flanks, each of the plurality of flanks being spaced farther from the central axis than the adjacent one of the plurality of troughs.

US Pat. No. 10,335,209

SYSTEMS AND METHODS FOR SPINAL FIXATION

Alphatec Spine, Inc., Ca...

1. A rod inserter tool for inserting a rod into a surgical site, the rod inserter tool comprising:a handle;
a shaft coupled to the handle; and
a rack-and-pinion mechanism that comprises a first rod and a second rod, the rack-and-pinion mechanism configured to slide out of the shaft and to rotate the rod about an axis orthogonal to the shaft;
wherein the handle is rotatably coupled to the shaft and operatively connected to the rack-and-pinion mechanism wherein rotation of the handle actuates the rack-and-pinion mechanism so as to rotate the rod;
wherein the rack-and-pinion mechanism further includes a pivot pin, a head having ratchet teeth and a guide slot, and a guide rod disposed within the guide slot, wherein the second rod is slidably engaged with the pivot pin; and
wherein the second rod is slidably coupled to the head, and a distal end of the second rod is pivotably coupled to a proximal end of the rod.

US Pat. No. 10,335,207

SPINOUS PROCESS PLATE FIXATION ASSEMBLY

NuVasive, Inc., San Dieg...

1. A spinous process plate fixation assembly, comprising:a pin plate including a first central aperture and a pin plate interior surface, and a first plurality of spikes extending from the pin plate interior surface;
a lock plate including second central aperture and a lock plate interior surface opposing the pin plate interior surface, and a second plurality of spikes extending from the lock plate interior surface;
a pin receptacle disposed within the pin plate, the pin receptacle configured to receive a lock pin;
a pivoting lock mechanism disposed within the lock plate, wherein the pivoting lock mechanism includes:
a threaded channel disposed within a top surface of the lock plate;
a lock chamber disposed within the lock plate;
a pivoting lock disposed within the lock chamber and including a lock slot in communication with the threated channel , wherein the pivoting lock includes a connector shaft passage configured to receive the lock side of the connector shaft, wherein the pivoting lock includes a compression slot proximal to the lock slot and opposite from a compression flat configures for orientation when the pivoting lock is compressed; and
a connector shaft extending from the pin plate to the lock plate and passing through the first central aperture and the second central aperture, the connector shaft including:
a pin side configured to receive the lock so as to secure the pin within the pin receptacle; and
a lock side opposite the pin side, the lock side configured to operatively engage the pivoting lock mechanism so as to pivotally secure the lock side with the pivoting lock mechanism.

US Pat. No. 10,335,205

MIS CROSS-CONNECTOR

Globus Medical, Inc., Au...

10. A bone fixation system for implanting in bone, comprising:a member that contacts a pair of substantially parallel elongate members, the member extending transverse to the elongate members; and
a plurality of locking caps that secure the member to the pair of elongate members,
wherein at least one of the plurality of locking caps comprises a cap portion and a hook portion, wherein the cap portion is adapted to rotate while the hook portion remains stationary, the hook portion having a receptacle and a lower surface,
wherein each locking cap is configured such that during fixation, the cap portion has a contact surface that presses upon a surface of one of the pair of elongate members while the receptacle receives the member, the hook portion presses down on the member, and the lower surface of the hook portion contacts one of the elongate members, and
wherein the hook portion is configured to receive the member in a manner to allow adjustment of the member prior to fixation.

US Pat. No. 10,335,204

BONE ANCHORING DEVICE

1. A polyaxial bone anchoring device comprising:a bone anchoring element having a head with a spherical-segment shaped portion and a shaft for anchoring to a bone;
a receiving part for coupling the bone anchoring element to a rod, the receiving part having a head receiving portion with an accommodation space for accommodating the head, and a rod receiving portion with a bore in communication with the accommodation space;
a pressure member movable in the bore and comprising a first surface for engaging the head, a second surface for engaging the rod, and two radially outwardly extending projections configured to latch into annular grooves in the receiving part to restrict axial movement of the pressure member in the receiving part; and
a sleeve-like insert piece comprising an endless ring separable from the pressure member and insertable into the receiving part;
wherein when the head of the bone anchoring element, the insert piece, and the pressure member are in the receiving part, the insert piece is positionable around and forms a seat for the spherical-segment shaped portion of the head, and the pressure member is movable to a position where the first surface of the pressure member directly contacts the head to lock the head relative to the receiving part.

US Pat. No. 10,335,194

HANDLES FOR NEEDLE ASSEMBLIES

SurGenTec, LLC, Boca Rat...

1. An impact handle comprising:an attachment portion configured to couple to a needle assembly;
a handle portion extending from the attachment portion and configured to be gripped in use, wherein the handle portion is movable relative to the attachment portion, wherein the handle portion is coupled to the attachment portion in a foldable arrangement; and
an impact strikeplate, the impact strikeplate configured to be struck with an instrument in use and configured to transfer forces form the instrument to the needle assembly to drive at least a portion of the needle assembly into bone when the attachment portion is coupled to the needle assembly.

US Pat. No. 10,335,186

METHODS AND APPARATUS FOR TREATING EMBOLISM

Inari Medical, Inc., Irv...

1. A device for treating an embolism that at least partially restricts blood flow through a blood vessel, the device comprising:an elongated shaft having a proximal region and a distal region;
an expandable braid attached to the distal region of the elongated shaft, the braid having a plurality of radially extending portions and at least one cylindrical portion, and the radially extending portions and the cylindrical portion being configured to move from a compressed state sized to fit in a delivery catheter to an expanded state;
wherein the cylindrical portion is between a pair of the radially extending portions, and in the expanded state the cylindrical portion is configured to press radially outward against the embolism;
wherein a diameter of the cylindrical portion in the expanded state is between four and eight times greater than a diameter of the cylindrical portion in the compressed state;
wherein the radially extending portions extend radially outward from the cylindrical portion in the expanded state such that portions of the embolism are retained between the radially extending portions; and
wherein the cylindrical portion has a first length along a longitudinal direction of the braid in the expanded state and the radially extending portions have a second length along the longitudinal direction of the braid in the expanded state that is less that the first length.

US Pat. No. 10,335,185

SNARE INSTRUMENT WITH A DISTAL SNARE STRUCTURE

1. An endoscopic snare instrument comprising:a shaft;
a plurality of bending tubes disposed in the shaft, with each of the plurality of bending tubes spaced around a circumference of the shaft and separated from an adjacent one of the plurality of bending tubes;
a snare structure disposed in the shaft, the snare structure comprising a plurality of intersecting noose wires including a first noose wire, a second noose wire and a third noose wire, each noose wire having a noose arch, with the first noose wire having a first base portion retained in a first bending tube of the plurality of bending tubes, a first noose arch extending from the first base portion to a second base portion, with the second base portion retained in the first bending tube of the plurality of bending tubes;
wherein, in an open position of the snare structure, the snare structure forms a trap opening with the noose arch of each of the plurality of intersecting noose wires extending in a circular shape in a plane transverse to a longitudinal direction of the shaft; and
wherein, in a contracted position of the snare structure, each noose arch is shortened and combines with another noose arch to form a knot in a central area of the trap opening, which shuts the trap opening and prevents an object trapped in the trap opening from escaping the trap opening;
wherein the first noose arch of the first noose wire is coupled to and intersects a second noose arch of the second noose wire and a third noose arch of the third noose wire, the second noose arch of the second noose wire is coupled to and intersects with the first noose arch of the first noose wire and the third noose arch of the third noose wire, and the third noose arch of the third noose wire is coupled to and intersects with the first noose arch of the first noose wire and the second noose arch of the second noose wire.

US Pat. No. 10,335,184

NEGATIVE PRESSURE TISSUE DEBRIDEMENT DEVICES, SYSTEMS, AND METHODS

KCI Licensing, Inc., San...

1. A system for debriding tissue from a tissue site, comprising:a debridement tool, comprising:
a housing comprising an interior space,
a reduced-pressure lumen adapted to communicate reduced pressure,
a debridement head moveable relative to the housing and positioned within the interior space,
an impeller moveable relative to the housing and positioned within the interior space in fluid communication with the reduced-pressure lumen and the debridement head, and
a drive system coupled between the impeller and the debridement head, the drive system being configured to impart movement from the impeller to the debridement head;
a therapy device, comprising:
a reduced-pressure source in fluid communication with the impeller through the reduced-pressure lumen,
a pressure sensor, and
a canister configured to retain fluid from the tissue site drawn through the debridement tool; and
a multi-lumen conduit comprising a primary lumen and a secondary lumen in fluid communication between the debridement tool and the therapy device, the primary lumen in fluid communication with the reduced-pressure lumen and the secondary lumen in fluid communication between the interior space and the pressure sensor.

US Pat. No. 10,335,181

TRANSDUCER/WAVEGUIDE ENGAGEMENT MECHANISMS FOR ULTRASONIC SURGICAL INSTRUMENTS

COVIDIEN LP, Mansfield, ...

1. An ultrasonic surgical instrument, comprising:a transducer assembly configured to supply ultrasonic energy, the transducer assembly including a distal engagement member;
a waveguide having a proximal engagement member configured to engage the distal engagement member of the transducer assembly, the waveguide configured to transmit the ultrasonic energy therealong from the proximal engagement member towards a distal end thereof for treating tissue; and
a latch mechanism including a lever having a handle portion, an intermediate portion, and an engaging portion including a first engagement member, wherein the intermediate portion of the lever is pivotably coupled to one of the waveguide or the transducer assembly about a pivot with the handle portion extending from one end of the intermediate portion and the engaging portion extending from the other end of the intermediate portion, and wherein the other of the waveguide or the transducer assembly includes a second engagement member, the handle portion selectively movable between an unlocked position and a locked position to transition the latch mechanism between:
a first condition, wherein the first and second engagement members are disengaged from one another such that the proximal engagement member of the waveguide and the distal engagement member of the transducer assembly are engagable with and disengageable from one another and movable relative to one another, and
a second condition, wherein the first and second engagement members are engaged with one another to thereby secure the proximal engagement member of the waveguide and the distal engagement member of the transducer assembly in fixed position relative to one another under compression between the pivot and the first and second engagement members.

US Pat. No. 10,335,180

MOTOR CONTROL AND FEEDBACK IN POWERED SURGICAL DEVICES

Ethicon LLC, Guaynabo, P...

1. A surgical device, comprising:a proximal handle;
an end effector coupled to the proximal handle and configured to engage tissue;
a cutting element configured to translate longitudinally along the end effector and cut the tissue engaged by the end effector;
a motor operatively coupled to the cutting element and configured to output power that causes the cutting element to translate along the end effector;
a first actuator configured to be moved by a user relative to the proximal handle and thereby cause the motor to output the power that causes the cutting element to translate along the end effector; and
a processor configured to
compare a position of the first actuator relative to the proximal handle and a longitudinal position of the cutting element relative to the end effector to determine whether a predetermined relationship between the positions is satisfied, and
in response to the predetermined relationship being determined to not be satisfied, cause the output power of the motor to change.

US Pat. No. 10,335,178

ANVIL GRASPER

Covidien LP, Mansfield, ...

1. A jaw assembly for use with a surgical grasping instrument comprising:a drive rod including a drive pin and a retention pin disposed along a longitudinal axis defined by the drive rod;
a first jaw having a first arcuate gripping portion and a first arm extending from the first arcuate gripping portion;
a second jaw having a second arcuate gripping portion and a second arm extending from the second arcuate gripping portion; and
a living hinge interconnecting the first and second arms of the respective first and second jaws, the living hinge held in place between the drive pin and the retention pin such that the living hinge and the drive rod are movable as a single construct, the first and second jaws transitionable between an open position in which the first and second arcuate gripping portions are spaced apart and a closed position in which the first and second arcuate gripping portions are in close cooperative alignment, wherein each arm of the first and second arms includes an engaging portion configured to be cammed against an elongate tubular member of the surgical grasping instrument to transition the first and second jaws between the open and closed positions, the engaging portions of the respective first and second arms being coplanar with remaining portions of the respective first and second arms.

US Pat. No. 10,335,172

METHODS AND APPARATUS FOR PREPARING A HEMISPHERICAL SURFACE

1. A composite reamer being attachable to a driving shaft and rotatable around a longitudinal axis of the shaft for preparing a desired hemispheric surface having a first radius, a spherical center, a pole, an equator and a rotational axis, respectively, comprising:a lower cutting element configured to couple to a lower frame to form a lower cutting portion of the reamer with a lower cutting surface for reaming a first portion defined from the pole to an intermediate latitude of the desired hemispheric surface, the lower cutting surface having a lower spherical cutting center and a lower rotational axis; and
an upper cutting element configured to couple to an upper frame to form an upper cutting portion of the reamer with an upper cutting surface for reaming at least a second portion defined from the intermediate latitude to the equator of the desired hemispheric surface, the upper cutting surface having an upper spherical cutting center and an upper rotational axis;
wherein the lower and upper rotational axis are coaxial with the longitudinal axis of the shaft, when the reamer is in the primary mode, the upper cutting elements depart from the second portion so that the first portion of the desired hemispherical surface is reamed, and in the finishing mode, the upper and lower cutting elements are connected end-to-end to form a continuous hemispheric cutting surface for reaming the first and second portion of the desired hemispherical surface.

US Pat. No. 10,335,169

ANGLED ORTHOPAEDIC DRIVER

Symmetry Medical Manufact...

1. An orthopaedic driver, comprising:a drivetrain having a driven end and a second end opposite said driven end, said drivetrain defining a first axis;
an instrument connector rotatably coupled to said second end of said drivetrain and defining a second axis angled relative to said first axis;
an angling bushing associated with said instrument connector; and
a housing having a straight portion covering at least a portion of said drivetrain and an angled portion connected to said straight portion, said housing including a bushing groove formed adjacent to an end of said angled portion, said angling bushing being held in said bushing groove within said housing, and said angled portion interacting with said angling bushing to hold said instrument connector angled relative to said drivetrain.

US Pat. No. 10,335,159

RELOADABLE MECHANICAL DEVICE FOR LIGATING LIVING TISSUE AND ACHIEVING HEMOSTASIS

BOSTON SCIENTIFIC SCIMED,...

1. A system for treating tissue, comprising:a clip assembly including a pair of clip arms, each of the clip arms extending from a proximal end to a distal end, the proximal ends of the clip arms connected to one another via a central member slidably received within a channel of a capsule to be moved between an open configuration, in which distal ends of the clip arms are separated from one another, and a closed configuration, in which distal ends of the clip arms are moved toward one another;
a cartridge for encasing the clip assembly including a groove formed therein to accommodate the clip assembly and an opening extending therein to in communication with a portion of the groove such that the groove is open to an exterior of the cartridge via the opening; and
an applicator releasably connectable to the central member to move the clip assembly between the open configuration and the closed configuration, a distal portion of the applicator insertable through the opening of the cartridge to reversibly engage and disengage from the central member while the central member remains intact within the capsule,
wherein the capsule includes a locking feature formed in a wall thereof for engaging an engaging tab at the proximal end of one of the clip arms to lock the clip arms in the closed configuration.

US Pat. No. 10,335,157

ASYMMETRICAL SURGICAL CLIP WITH PENETRATING LOCK, NON-SLIP CLAMPING SURFACE, SEVERABLE HINGE, HINGE BOSS AND PIVOTING APPLICATOR TIP

Covidien LP, Mansfield, ...

1. A surgical clip comprising:a pair of opposed arms joined at a hinged end by an integrally formed flexible hinge, the pair of opposed arms comprising:
a first arm having a first arm width, the first arm comprising a clamping side with a plurality of spaced-apart longitudinally-oriented wedge shaped protrusions, each of the wedge shaped protrusions comprising chamfered surfaces extending from outer lateral sides of the first arm and converging at a vertex such that each of the wedge shaped protrusions extends across the first arm width; and
a second arm having a second arm width, the second arm comprising a clamping side with a plurality of spaced-apart longitudinally-oriented V-shaped trough segments and comprising chamfered surfaces that converge at a vertex, the V-shaped trough segments extending across the second arm width, such that the clamping side of the second arm faces the clamping side of the first arm, and the V-shaped trough segments conform to the shape of the wedge shaped protrusions and are aligned to receive the wedge shaped protrusions,
each arm having a free end, one of the first and second arms including a male locking pin near the free end, and the other of the first and second arms including a female aperture near the free end, the first and second arms movable from an open configuration in which the male locking pin is spaced from the female aperture to a locked configuration in which the male locking pin is engaged with the female aperture, said male locking pin including a tissue piercing head, said tissue piercing head being configured to penetrate tissue in the path of the male locking pin when the male locking pin is urged towards the female aperture, and said female aperture being configured to engage the tissue piercing head of the male locking pin and resist withdrawal of the head when the head has been urged through the female aperture into the locked configuration.

US Pat. No. 10,335,155

POSITIONING AND DETACHING IMPLANTS

Covidien LP, Mansfield, ...

1. A system for placing an implant at an aneurysm, comprising:a tubular member having (a) a member lumen in the tubular member and (b) an opening at a distal end portion of the tubular member;
an implant configured for placement at an aneurysm and having an enlarged portion positioned in the member lumen proximal to the opening; and
an elongate member extending in the lumen and having an expandable/compressible body (a) positioned at least partially distal to the enlarged portion in the lumen and (b) expanded distal to the enlarged portion to retain the enlarged portion in the lumen, and wherein the expandable/compressible body comprises a mesh.

US Pat. No. 10,335,152

PARTIAL AORTIC OCCLUSION DEVICES AND METHODS FOR CEREBRAL PERFUSION AUGMENTATION

Zoll Circulation, Inc., ...

1. A device comprising:an elongate member having proximal and distal regions;
a first expandable member engaged with the distal region;
a second expandable member engaged with the elongate member proximal the first expandable member; and
a first mechanism disposed about the first expandable member for centering the first expandable member within a patient's blood vessel, wherein the first centering mechanism is established at least in part by struts mounted to the elongate member at first ends proximal to the first expandable member and mounted to the elongate member at second ends distal to the first expandable member.

US Pat. No. 10,335,150

STAPLE CARTRIDGE COMPRISING AN IMPLANTABLE LAYER

Ethicon LLC, Guaynabo, P...

1. A staple cartridge assembly for stapling patient tissue, comprising:a staple cartridge including a deck, wherein said deck comprises a plurality of staple cavities, and wherein said deck is configured to support the tissue;
a plurality of staples removably stored in said staple cavities;
an implantable layer positioned adjacent to said deck, wherein said implantable layer comprises a composite absorbable material, wherein said composite absorbable material comprises at least two distinct fibrous materials, and wherein at least one freeze-dried medicament is releasably held on at least one of said fibrous materials; and
a liquid impermeable film wrapped around said staple cartridge and said implantable layer.

US Pat. No. 10,335,149

ARTICULATABLE SURGICAL INSTRUMENTS WITH COMPOSITE FIRING BEAM STRUCTURES WITH CENTER FIRING SUPPORT MEMBER FOR ARTICULATION SUPPORT

Ethicon LLC, Guaynabo, P...

20. A surgical instrument, comprising:an elongate shaft assembly defining a shaft axis;
a surgical end effector operably coupled to said elongate shaft assembly by an articulation joint such that said surgical end effector is selectively articulatable relative to said elongate shaft assembly about an articulation axis that is transverse to said shaft axis;
a firing member movably supported for axial travel between a proximal end portion of said surgical end effector and a distal end portion of said surgical end effector;
a central firing beam support member axially aligned along said shaft axis and extending across said articulation joint and comprising a distal end coupled to said surgical end effector and a proximal end attached to said elongate shaft assembly; and
a longitudinally movable flexible firing beam assembly comprising a plurality of beam layers such that as said longitudinally movable flexible firing beam assembly is distally advanced, said longitudinally movable flexible firing beam assembly is bifurcated by said central firing beam support member so that portions of said longitudinally movable flexible firing beam assembly pass adjacent to each lateral side of said central firing beam support member, said longitudinally movable flexible firing beam assembly configured to drive said firing member between said proximal and distal end portions of said surgical end effector.

US Pat. No. 10,335,145

MODULAR SURGICAL INSTRUMENT WITH CONFIGURABLE OPERATING MODE

Ethicon LLC, Guaynabo, P...

1. A surgical instrument, comprising:a drive system;
an electric motor mechanically coupled to the drive system;
a controller electrically coupled to the electric motor; and
at least two user-actuated input devices electrically coupled to the controller; and
wherein the controller is configured to operate the electric motor according to a first operating mode for the electric motor;
wherein the controller is configured to detect activation of a first user-actuated input device and to override the first operating mode for the electric motor upon detecting the activation of the first user-actuated input device and to detect activation of a second user-actuated input device to operate the electric motor in a second operating mode according to an input associated with the second user-actuated input device upon the controller overriding the first operating mode for the electric motor.

US Pat. No. 10,335,144

SURGICAL INSTRUMENT

Ethicon LLC, Guaynabo, P...

1. A surgical stapling instrument, comprising:a stapling assembly comprising a first jaw and a second jaw, wherein said first jaw is movably coupled to said second jaw;
a shaft configured to support said stapling assembly;
a firing member configured to transmit a firing motion to said stapling assembly, wherein said firing member comprises:
a cutting member;
a first camming member configured to engage said first jaw; and
a second camming member configured to engage said second jaw;
a closure member configured to transmit a push-to-close motion to said stapling assembly;
a manually-actuatable closure trigger which is operable to impart said push-to-close motion to said closure member; and
a motor, wherein said motor is operably coupled to said firing member to impart said firing motion to said firing member.

US Pat. No. 10,335,142

TWIST NEEDLE PASSER CLOSURE DEVICE

BOSTON SCIENTIFIC SCIMED,...

1. A tissue closure device, comprising:a needle extending longitudinally from a first end to a second end;
a suture extending from a distal end attached to the needle to a proximal end extending to a proximal end of the device;
a proximal head including a proximal slot extending longitudinally therethrough and a proximal locking mechanism for releasably engaging the first end of the needle in the proximal slot in a first configuration; and
a distal head movably coupled to the proximal head so that the proximal and distal heads are movable relative to one another between an open configuration, in which a target tissue is received therebetween, and a closed configuration, in which the target tissue is gripped therebetween, the distal head including a distal slot extending longitudinally therethrough and a distal locking mechanism for releasably engaging the second end of the needle in the distal slot in a second configuration, the needle movable between the first and second configurations when the proximal and distal heads are in the closed configuration by rotating the needle relative to the proximal and distal heads, the needle alternatingly passed between the proximal and distal heads to thread the suture through the target tissue.

US Pat. No. 10,335,140

MENISCAL REPAIR SYSTEMS AND METHODS

Cayenne Medical, Inc., S...

1. A device for repairing a tear in a portion of tissue, comprising:a proximal actuator portion;
a transfer needle extending distally from the proximal actuator portion and having a distal tip for piercing tissue;
a catch needle extending distally om the proximal actuator portion and having a distal tip for piercing tissue;
a suture needle disposed within a lumen in said transfer needle, said suture needle being extendable from said transfer needle toward said catch needle and retractable from said catch needle toward said transfer needle; and
a window disposed on said transfer needle, through which said suture needle may be deployed, said window having two substantially parallel sides and a bearing surface which is disposed substantially perpendicularly to a path of the suture needle as the suture needle traverses into and out of said window;
wherein said window has a length that is shorter than required to permit free translation of the suture needle into and out of the window, so that an interfering contact is created between a first surface of the suture needle and the edge of the transfer needle window; and
wherein said suture needle comprises a second surface thereof which is substantially flat and on an opposing side of the suture needle relative to the first surface, so that the interfering contact between the first suture needle surface and the edge of the transfer needle window causes the substantially flat second suture needle surface against the transfer needle bearing surface.

US Pat. No. 10,335,137

FENESTRATED LOCKING SUTURE ANCHOR ASSEMBLY

1. A method of tissue repair comprising:driving a tip structure of an anchor system into a bone hole with an anchor driver, the anchor system comprising:
a sleeve comprising:
at least one open helical coil having a proximal end and a distal end wherein the at least one open helical coil defines an internal volume communicating with a region exterior to the at least one open helical coil through a spacing between turns of the at least one open helical coil, and
at least one rib disposed within the internal volume, connected to at least two turns of the at least one open helical coil, wherein the at least one rib is engageable with a grooved outer shaft of the anchor driver;
wherein the tip structure is engageable with the sleeve, the tip structure comprising:
a body defining an internal cavity comprising:
a distal region defining an aperture sized to accept a suture, wherein the aperture is connected to the internal cavity, and
a proximal region sized to engage the distal end of the sleeve, and a suture capture member positioned within the internal cavity and advanceable distally through the internal cavity into the aperture to capture the suture in a locked position;
advancing, using the anchor driver, the suture capture member until a feedback member of a torque and/or travel limiter of the anchor driver indicates full advancement to capture the suture in a distal, suture-locked position, the feedback member providing audible feedback to indicate the full advancement; and
advancing the sleeve into the bone and into engagement with the tip structure using the anchor driver;
wherein the anchor driver further comprises an axially compliant member configured to allow a relative motion between the grooved outer shaft and an inner shaft along a longitudinal axis of the anchor driver, the axially compliant member being separate and distinct from a spring of the torque and/or travel limiter.

US Pat. No. 10,335,133

EXPANDABLE DEVICES FOR POSITIONING ORGANS

Manual Surgical Sciences ...

1. A positioning device capable of being introduced against an interior surface of an organ and of diverting a pathway of a portion of the organ, comprising:a shaft with a longitudinal axis; and
an expandable element at a distal end of the shaft, the expandable element being:
substantially flaccid in an unexpanded state and substantially rigid and substantially non-compliant when in an expanded state; and
asymmetrical about the longitudinal axis in the expanded state such that the positioning device, in the expanded state, is capable of repositioning the organ,
the expandable element comprising a balloon expandable to a shape that includes a plurality of bends capable of diverting a portion of the organ, the balloon including:
a diverting element that extends away from the longitudinal axis at a first bend defining a first obtuse angle when the expandable element is in the expanded state;
a spacing element distal to, continuous with, and extending away from the diverting element at a second bend defining a second obtuse angle to the diverting element when the expandable element is in the expanded state, at least a portion of a length of the spacing element being oriented substantially parallel to the longitudinal axis when the expandable element is in the expanded state; and
a convergent element distal to, continuous with, and extending away from the spacing element at a third bend defining a third obtuse angle to the spacing element when the expandable element is in the expanded state, the convergent element extending toward the longitudinal axis when the expandable element is in the expanded state,
with corners at the first bend, at the second bend between the diverting element and the spacing element, and at the third bend between the spacing element and the convergent element respectively defining the first obtuse angle between the longitudinal axis and the diverting element, the second obtuse angle between the diverting element and the spacing element, and the third obtuse angle between the spacing element and the convergent element,
the diverting element, the spacing element, and the convergent element having cross-sectional shapes and cross-sectional dimensions capable of diverting the organ upon expansion of the expandable element without distending the organ or causing trauma to the organ upon expansion of the expandable element,
the cross-sectional shapes and cross-sectional dimensions of the diverting element, the spacing element, and the convergent element being the same as one another and uniform along lengths of the diverting element, the spacing element, and the convergent element when the expandable element is expanded.

US Pat. No. 10,335,131

METHODS FOR PREVENTING TISSUE MIGRATION

INTUITIVE SURGICAL OPERAT...

1. A method of inhibiting tissue migration during a procedure, comprising: positioning an open area of a non-inflatable hood against or adjacent to a tissue region, where the hood expands when unconstrained to a deployed configuration which defines the open area; displacing an opaque fluid with a transparent fluid from the open area through a distal opening in the hood defined by the hood and the tissue region; engaging a portion of the tissue region within the open area via an end effector advanced through the open area and which grasps onto the portion, the end effector including a tapered section through which a lumen extends, the tapered section being tapered along its entire length, the tapered section being tapered along a longitudinal axis of the end effector and including threads extending from a surface of the tapered section in a direction orthogonal to the longitudinal axis, wherein engaging comprises screwing the tapered and threaded section of the end effector into the portion of tissue region; and piercing the tissue region while displacing the opaque fluid with the transparent fluid through the distal opening of the hood and while maintaining engagement of the portion of the tissue region such that distal movement of the tissue is inhibited.

US Pat. No. 10,335,128

BIOPSY DEVICE AND INSERTABLE BIOPSY NEEDLE MODULE

C. R. Bard, Inc., Frankl...

1. A biopsy device, comprising:a disposable unit including:
a needle carrier configured to move in a first direction and a second direction opposite to the first direction; and
a biopsy needle and a cutting element disposed therein, wherein both the biopsy needle and the cutting element are coupled to the needle carrier, and a sample chamber in the biopsy needle, the cutting element having a cutting blade, the cutting element being configured to move the cutting blade relative to the sample chamber; and
a drive unit configured to receive the disposable unit, the drive unit having a needle-shooting mechanism with a cocked configuration and a released configuration, the needle-shooting mechanism having a spring and a clamping carriage, the clamping carriage being configured to drivably engage the needle carrier;
the drive unit configured to move the cutting element to drive the needle carrier in the second direction by a predetermined distance to move the needle-shooting mechanism to the cocked configuration; and
the drive unit having a user-actuatable control unit configured to release the needle-shooting mechanism to cause the needle-shooting mechanism to shoot the needle carrier including the biopsy needle simultaneously with the cutting element in the first direction by an amount of the predetermined distance.

US Pat. No. 10,335,119

ULTRASOUND IMAGE DIAGNOSTIC APPARATUS

KONICA MINOLTA, INC., To...

1. An ultrasound image diagnostic apparatus comprising:an ultrasound probe which transmits ultrasound to a subject, receives reflected ultrasound, and generates a reception signal;
a transmitter which generates an excitation signal and outputs the excitation signal to the ultrasound probe to instruct the ultrasound probe to generate the transmitted ultrasound;
a receiver which receives the reception signal from the ultrasound probe; and
an image generator which extracts harmonic components from the reception signal and generates ultrasound image data based on the harmonic components,
wherein the transmitter drives the ultrasound probe with the excitation signal to instruct the ultrasound probe to transmit the transmitted ultrasound that satisfies the following requirements: a wave packet duration is equivalent to or more than the length of 1.5 waveforms at the lower limit frequency of the ?6 dB transmission bandwidth of the ultrasound probe; signal intensity of frequency components in the ?6 dB transmission bandwidth has a standard deviation of 6 or less; and lower limit frequency components in the ?6 dB transmission bandwidth have a signal intensity of ?8 [dB] or higher, the signal intensity being normalized with respect to the maximum intensity of 0 [dB], and
wherein the image generator generates the ultrasound image data based on the harmonic components in the reception signal obtained after the transmission of the transmitted ultrasound.

US Pat. No. 10,335,111

ELECTRONIC CASSETTE SYSTEM AND ELECTRONIC CASSETTE

FUJIFILM Corporation, To...

1. An electronic cassette system comprising:an electronic cassette including an image detector and a housing for housing the image detector, the image detector detecting a radiation image of a subject based on radiation having been transmitted through the subject, and the housing having a front surface on which the radiation is incident, a rear surface facing the front surface, and four side surfaces;
a female connector disposed in the housing; and
a male connector to be connected to the female connector, the male connector extending from a side-surface side of the housing in a direction parallel to the front surface and the rear surface of the housing, wherein
a center position of the female connector is located closer to the rear surface of the housing compared with a center position of the housing in a thickness direction of the housing perpendicular to the front surface and the rear surface,
the housing has an inclined surface which is formed at least between one of the side surfaces and the rear surface and inclined relative to the one of the side surfaces and the rear surface, and
the female connector includes an insertion port configured to open only in the inclined surface and to receive an insertion of the male connector.

US Pat. No. 10,335,110

RADIOGRAPHIC IMAGE CAPTURING SYSTEM AND RADIOGRAPHIC IMAGE CAPTURING APPARATUS

KONICA MINOLTA, INC., To...

1. A radiographic image capturing system comprising:a radiographic image capturing apparatus comprising:
a two-dimensional array of radiation detecting elements which each have a first electrode and a second electrode; and
a control circuit which controls reading of image data from each of the radiation detecting elements based on a predetermined capturing sequence; and
an image processor which has first gain data to correct gains of the radiation detecting elements in the radiographic image capturing apparatus, which corrects the image data based on the first gain data, and which generates a radiographic image based on the corrected image data, wherein
a reverse bias voltage is applied to the first electrode of each of the radiation detecting elements of the radiographic image capturing apparatus,
a corresponding signal line is connected to the second electrode of each of the radiation detecting elements via a switching element,
the control circuit of the radiographic image capturing apparatus is capable of varying at least one of the reverse bias voltage and a signal line voltage to be applied to the corresponding signal line, and
after resetting of the radiation detecting elements, the control circuit reads a signal value from each of the radiation detecting elements by varying at least one of the reverse bias voltage and the signal line voltage, creates second gain data based on the read signal value, and corrects the radiographic image with the first gain data and the second gain data.

US Pat. No. 10,335,109

RADIATION PHASE-CONTRAST IMAGING DEVICE

Shimadzu Corporation, Ky...

1. A radiation phase difference imaging apparatus comprising:a radiation source which radiates a plurality of radiations having different wavelengths;
a phase grating in which absorbers extending in one direction and absorbing a radiation are arranged in a direction orthogonal to one direction;
a detection unit which detects a self-image of the phase grating formed by a Talbot interference on a detection surface detecting a radiation;
a self-image picture generation unit which generates a self-image picture capturing a self-image based on an output of the detection unit; and
a fluoroscopic image generation unit which generates a fluoroscopic image obtained by imaging a phase difference inside a subject based on the self-image picture,
wherein a distance between the phase grating and the detection surface of the detection unit is determined based on how much the self-image captured on the detection surface is disturbed by noise.

US Pat. No. 10,335,104

MULTI ENERGY X-RAY MICROSCOPE DATA ACQUISITION AND IMAGE RECONSTRUCTION SYSTEM AND METHOD

Carl Zeiss X-ray Microsco...

1. An x-ray imaging system, comprising:an x-ray source system for generating a high energy x-ray beam and a low energy x-ray beam;
a sample holder for rotating a sample in the high energy x-ray beam and the low energy x-ray beam from the x-ray source system to perform a low-energy scan and a high-energy scan of the sample;
a detector system for detecting the high energy x-ray beam and the low energy x-ray beam after transmission through the sample to generate projection data;
a computer system generating a low-energy reconstructed tomographic volume data set from the low-energy scan and generating a high-energy reconstructed tomographic volume data set from the high-energy scan in the computer system from the projection data, and rendering slice views from the low-energy and high-energy reconstructed tomographic volume data sets on a display device of the computer system and presenting a mathematically combined synthetic slice on the display device of the computer system, wherein the slice view from the low-energy reconstructed tomographic volume data set, the slice view from the high-energy reconstructed tomographic volume data set, and the mathematically combined synthetic slice are simultaneously displayed on the display device by the computer system;
wherein the computer system further presents an interactive slice selection graphic that is displayed on the display device simultaneously with the slice view from the low-energy reconstructed tomographic volume data set, the slice view from the high-energy reconstructed tomographic volume data set, and the mathematically combined synthetic slice, and wherein a different low-energy slice view from the low-energy reconstructed tomographic volume data set and a different high-energy slice view are displayed in response to user selection of a different slice view within the interactive slice selection graphic; and
wherein the computer system displays a two-dimensional histogram of high-energy x-ray pixel intensity values versus low-energy x-ray pixel intensity values in which intensity of points on the histogram is associated with the count of voxels with the low-energy and high-energy pixel intensity values respectively.

US Pat. No. 10,335,103

IMAGE DISPLAY SYSTEM, RADIATION IMAGING SYSTEM, RECORDING MEDIUM STORING IMAGE DISPLAY CONTROL PROGRAM, AND IMAGE DISPLAY CONTROL METHOD

FUJIFILM CORPORATION, To...

1. An image display system comprising:a tomographic image generation unit that:
comprises an x-ray source disposed opposite an x-ray image detector with an examined breast of a subject there between, such that the breast is irradiated by x-rays from the source, said x-rays incident upon the breast at different angles of incidence with respect to the x-ray image detector,
acquires a plurality of x-ray images captured by the x-ray image detector at the respective angles from the x-ray image detector, and
generates a tomographic image on the basis of the acquired plurality of x-ray images, wherein said tomographic image is reconstructed with respect to a detection plane of the x-ray image detector;
a height specification unit that specifies a height of a nipple of the breast with respect to the detection plane; and
a display control unit that causes a display unit to display the tomographic image together with information relating to the nipple height specified by the height specification unit; wherein
the display unit, on a graphical axis on the screen of the display that shows the thickness of the breast, (1) displays information that indicates the height of a slice of the tomographic image that is displayed, and (2) displays information that indicates a location of the nipple height, the location of the nipple height being relative to the thickness of the breast shown on the axis; and wherein
the axis that shows thickness of the breast is graphically displayed in the tomographic image that is displayed, the axis is graphically displayed in a specific area in the displayed tomographic image, in the specific area, the breast is not displayed, and the information that indicates the nipple height is displayed with respect to the axis, and the information that indicates the nipple height is graphically displayed in the specific area.

US Pat. No. 10,335,102

MOBILE X-RAY IMAGING APPARATUS

SAMSUNG ELECTRONICS CO., ...

1. A mobile X-ray imaging apparatus comprising:a main body comprising a driving wheel;
an X-ray source configured to radiate an X-ray to an object;
a first column rotatably coupled to the main body and extending in an extension direction;
a second column slidably coupled to the first column in the extension direction of the first column;
an X-ray source support body that supports the X-ray source and slidably coupled to the second column;
a first display provided in the main body and configured to visually display an X-ray irradiation condition;
a second display coupled to the X-ray source and configured to control an operation of the mobile X-ray imaging apparatus; and
a visual indicator that is attached to one end of the second column, the visual indicator being configured to move in the extension direction together with the second column when the second column slidably moves with respect to the first column, which stands stationary in the extension direction,
wherein a color of the visual indicator is changed based on receiving, a signal that preheating of a generator is started and the visual indicator displays the color during the preheating of the generator.

US Pat. No. 10,335,096

SYSTEM AND METHOD FOR AUXILIARY ANATOMY SCANNING UTILIZING A COMPUTED TOMOGRAPHY (CT) SYSTEM

GENERAL ELECTRIC COMPANY,...

1. A method, comprising:coupling an extension disposed on a first end of a cradle nearest a gantry bore of a stationary computed tomography (CT) imaging system to a second end of a board nearest the gantry bore, wherein a subject to be imaged is disposed on the board;
positioning the board with the subject on it into the gantry bore via the cradle by pulling on the second end of the board;
partially supporting the subject to be imaged on the board extending from a mobile patient transport into the gantry bore while partially supporting both the subject and the board with the cradle extending from a table; and
acquiring a single imaging volume, during an imaging scan with the stationary CT imaging system, without moving the subject while the subject remains partially supported on the board extending from the mobile patient transport.

US Pat. No. 10,335,094

BREAST BIOPSY AND NEEDLE LOCALIZATION USING TOMOSYNTHESIS SYSTEMS

HOLOGIC, INC., Marlborou...

1. A method for needle localization for breast biopsy, said method comprising:performing a tomosynthesis scan of a patient's breast using a source of an imaging x-ray beam that moves through a multiplicity of imaging positions along a source trajectory, and obtaining image data from the tomosynthesis scan and deriving therefrom tomosynthesis reconstructed images representing respective slices of the breast;
displaying at least some of the tomosynthesis reconstructed images of the patient's breast;
receiving an indication on at least one of the tomosynthesis reconstructed images of an area of interest within the patient's breast, and determining therefrom three-dimensional coordinates of the area of interest;
positioning a biopsy needle based on the determined three-dimensional coordinates of the area of interest;
emitting a verification x-ray beam from the source at a plurality of verification x-ray positions each disposed at an orientation to the biopsy needle and breast so as to verify the position of the biopsy needle relative to the area of interest or to verify that tissue located at the area of interest has been removed, and
reducing image artifacts due to the presence of the biopsy needle or other radiopaque materials.

US Pat. No. 10,335,093

BIOSIGNAL PROCESSING METHOD AND APPARATUS

Samsung Electronics Co., ...

1. A biosignal processing method comprising:extracting reference points from a waveform of a biosignal;
determining a pulse direction of the biosignal based on the extracted reference points;
determining a feature point of the biosignal based on a feature point determining method corresponding to the pulse direction; and
outputting bioinformation based on the feature point,
wherein the extracting of the reference points comprise extracting a first reference point having a highest signal value from among neighboring first candidate reference points, and extracting a second reference point having a lowest signal value from among neighboring second candidate reference points, and
wherein the determining of the pulse direction comprises determining pulse sharpness levels corresponding to each of the first reference point and the second reference point, and determining the pulse direction based on the pulse sharpness levels.

US Pat. No. 10,335,091

METHOD AND APPARATUS TO INFER OBJECT AND AGENT PROPERTIES, ACTIVITY CAPACITIES, BEHAVIORS, AND INTENTS FROM CONTACT AND PRESSURE IMAGES

Tactonic Technologies, LL...

1. An apparatus for determining cognitive capacity decline of a person comprising:a sensor portion of a plurality of sensor tiles forming a walkway with which the person makes contact and to which the person applies pressure a number of times a day;
a computer in communication with the sensor portion that receives signals indicative of gait of the person moving on the walkway the number of times a day from the sensor portion corresponding to the contact and pressure applied to the sensor portion by the person, determines from the signals over time the cognitive capacity decline based on center of pressure measurements of footsteps of the person; and
an output in communication with the computer that identifies the cognitive capacity decline determined by the computer.

US Pat. No. 10,335,088

APPARATUS AND METHOD FOR DETECTING BIOMETRIC INFORMATION

SAMSUNG ELECTRONICS CO., ...

1. A biometric information detecting apparatus comprising:a bio-signal measurer configured to measure a bio-signal and comprising a light emitter and a light receiver, the light emitter being configured to emit an optical signal and the light emitter being configured to detect the optical signal that is modulated by a target object;
a low-frequency signal obtainer circuitry configured to obtain a low-frequency signal from the bio-signal measured by the bio-signal measurer; and
a signal processor configured to analyze a waveform of the bio-signal in response to determining that the low-frequency signal obtained from the bio-signal is within a reference range,
wherein the signal processor does not start analyzing the waveform of the bio-signal until it is determined that the low-frequency signal obtained from the bio-signal is within the reference range.

US Pat. No. 10,335,082

MEDICATION DELIVERY DEVICE WITH MULTI-RESERVOIR CARTRIDGE SYSTEM AND RELATED METHODS OF USE

Picolife Technologies, LL...

1. A miniature medication delivery system for delivery of medicament to a body of a user, comprising:a housing configured to be affixed to the body, the housing comprising control electronics, a power source, a sensor support socket, and a plurality of electromagnetic coils;
an adhesive patch platform attached to the housing, wherein the adhesive patch platform is configured to affix the housing to the body;
a first sensor configured to continuously monitor a parameter of the user removably connectable through the sensor support socket, wherein the first sensor is configured to be inserted into the body of the user through the sensor support socket;
an outlet mechanism disposable within the body of the user; and
a cartridge system removably connectable to the housing comprising:
a first reservoir comprising a first medicament;
a second reservoir comprising a second medicament; and
a pump mechanism configured to pump the first medicament from the first reservoir and the second medicament from the second reservoir to the outlet mechanism, wherein the control electronics are in electrical communication with the first sensor, the pump mechanism comprising:
a first pump insert body in fluid communication with the first reservoir, wherein the first pump body comprises first magnet, a plurality of fluid channels, a fluid receiving opening, and a fluid discharge opening;
a second pump insert body in fluid communication with the second reservoir, wherein the second pump insert body comprises a second magnet; and
a flexible member disposed in between the first and second pump insert bodies, wherein the flexible member is operably coupled to the first and second magnets;
wherein the plurality of electromagnetic coils are configured to selectively control position of one or both of the first and second magnets relative to the plurality of electromagnetic coils.

US Pat. No. 10,335,075

ADVANCED CALIBRATION FOR ANALYTE SENSORS

DexCom, Inc., San Diego,...

1. A method for improving blood glucose sensing using a glucose sensor, the method comprising:receiving a priori calibration distribution information obtained prior to a sensor session, the a priori calibration distribution information including probability information about combinations of sensitivity and baseline;
receiving blood glucose sensor data from the glucose sensor during a sensing session for the glucose sensor, the blood glucose sensor data including at least one sensor data point; and
calibrating, during the sensor session, the at least one sensor data point without relying exclusively on factory calibration, assumptions of blood glucose accuracy, or reference data, wherein calibrating includes:
receiving one or more real-time inputs during the sensor session, each of the one or more real-time inputs being capable of influencing calibration of the glucose sensor;
forming a posteriori calibration distribution information using a Bayesian approach and based on the one or more real-time inputs;
converting, in real-time during the sensor session, the at least one sensor data point from the glucose sensor to calibrated sensor data based on the a posteriori calibration distribution information; and
displaying an indication of the calibrated sensor data for the glucose sensor.

US Pat. No. 10,335,073

ENDOSCOPE SYSTEM, PROCESSOR DEVICE THEREOF, AND METHOD FOR CONTROLLING ENDOSCOPE SYSTEM

FUJIFILM Corporation, To...

1. An endoscope system comprising:a light source for applying special illumination light to a body portion, said special illumination light having a wavelength at which oxyhemoglobin and deoxyhemoglobin have different absorption coefficients;
an imaging device having a normal image sensor and a high-sensitivity image sensor whose sensitivity is higher than that of said normal image sensor, for imaging reflected light of said special illumination light from said body portion;
a processor configured for:
measuring a reflected light amount of said special illumination light from said body portion;
choosing which one of said normal and high-sensitivity image sensors to use for imaging said reflected light of said special illumination light from said body portion in accordance with said measured reflected light amount of said special illumination light; and
producing a special image depicting an oxygen saturation level of blood based on said signal obtained by imaging said reflected light of said special illumination light from said body portion with use of selected one of said normal and high-sensitivity image sensors
wherein
said processor measures said reflected light amount of said special illumination light by using a pixel value outputted from one of said normal and high-sensitivity image sensors, and said processor chooses which one of said normal and high-sensitivity image sensors to use for imaging said reflected light of said special illumination light from said body portion based on said reflected light amount;
when said normal image sensor is used, said processor stops using said normal image sensor and starts using said high-sensitivity image sensor for imaging said reflected light of said special illumination light from said body portion, if said pixel value corresponding to said reflected light amount is less than a first sensor selection threshold value; and
when said high-sensitivity image sensor is used, said processor stops using said high-sensitivity image sensor and starts using said normal image sensor for imaging said reflected light of said special illumination light from said body portion, if said pixel value corresponding to said reflected light amount is more than a second sensor selection threshold value, wherein
said second sensor selection threshold value is larger than said first sensor selection threshold value.

US Pat. No. 10,335,069

OXIMETER PROBE WITH LIGHT WAVELENGTHS TO AVOID SURGICAL DYES

ViOptix, Inc., Newark, C...

1. A method comprising:providing a sensor head for a tissue oximetry device comprising:
detectors arranged on the sensor head; and
first and second light source structures positioned in a line on the sensor head, wherein
the first source structure is configured to emit at least a first wavelength of light longer than about 730 nanometers,
the second source structure is configured to emit at least a second wavelength of light longer than about 730 nanometers,
a first detector of the detectors is a first distance from the first light source,
a second detector of the detectors is a second distance from the second light source,
a third detector of the detectors is a third distance from the first light source,
no detector is positioned between the first detector and the third detector, the line passes between the first detector and the third detector, the line is closer to the first detector than the third detector, and the first, second, and third detectors are not on the line,
the first distance and the second distance are equal, and
the first distance and the third distance are not equal; and
enclosing a processing module in a housing coupled to the sensor head, wherein the processing module is adapted for determining an oxygen saturation value for a tissue to be measured using the first wavelength of light from the first source structure and the second wavelength of light from the second source structure emitted into the tissue and corresponding reflected light received by at least two of the detectors.

US Pat. No. 10,335,068

MULTI-STREAM DATA COLLECTION SYSTEM FOR NONINVASIVE MEASUREMENT OF BLOOD CONSTITUENTS

MASIMO CORPORATION, Irvi...

1. A noninvasive physiological sensor comprising:a front-end interface comprising:
one or more detectors, each detector including a respective set of photodiodes;
one or more inputs configured to receive signals from respective one or more detectors in the sensor;
a respective two or more transimpedance amplifiers for each respective detector and configured to convert the signals from the respective sets of photodiodes into output signals for each of the respective sets of photodiodes; and
a respective averager, coupled to the respective two or more transimpedance amplifiers for each respective detector, and configured to average the output signals from the respective two or more transimpedance amplifiers into a respective output signal.

US Pat. No. 10,335,059

FALL DETECTION SYSTEM AND METHOD

KONINKLIJKE PHILIPS N.V.,...

1. A fall detection system for use in detecting falls by a user, the fall detection system comprising:a processing unit configured to determine context information about the user and/or an environment in which the user is located, and to increase a detection sensitivity of a fall detection algorithm used to detect falls by the user based on the determined context information indicating that the user is at an increased risk of falling, the increase in detection sensitivity occurring while the increased risk of falling is indicated by the determined context information.

US Pat. No. 10,335,053

SYSTEM AND METHOD FOR CARDIAC MONITORING USING ADAPTIVE SENSITIVITY/SPECIFICITY LEVELS

Medtronic Monitoring, Inc...

1. A method of adaptive arrhythmia detection, the method comprising:monitoring ECG signals of a patient via a patient medical device;
detecting arrhythmic ECG segments based on a heart rate threshold and an initial sensitivity level associated with the heart rate threshold;
incrementing a count of detected arrhythmic ECG segments in response to each arrhythmic ECG segment detected; and
increasing the sensitivity level associated with the heart rate threshold in response to the count of detected arrhythmic ECG segments failing to exceed a threshold within a given time period.

US Pat. No. 10,335,043

IMPLANTABLE VITAL SIGN SENSOR

Thomas Jefferson Universi...

1. A confocal displacement sensor, comprising:a light source configured to emit light;
a first lens, the first lens being configured to focus the light emitted from the light source;
a beam splitter, the beam splitter being configured to receive the focused light from the first lens and split the focused light into a first beam of light and a second beam of light;
a first prism, the first prism being configured to refract light from the first beam of light;
a reference detector, the reference detector being configured to receive the refracted first beam of light from the first prism;
a wave plate, the wave plate being configured to receive the second beam of light from the beam splitter;
a second lens, the second lens being configured to further focus the second beam of light from the wave plate;
a diaphragm housing, the diaphragm housing having a first portion, a second portion, and a lumen there through, the first portion of the diaphragm housing having a first length and the second portion of the diaphragm housing having a second length, the second length being longer than the first length, the first portion of the diaphragm housing having a first diameter and the second portion of the diaphragm housing having a second diameter, the first diameter being larger than the second diameter, the diaphragm housing being sized to releasably retain the second lens inside the lumen;
a diaphragm, the diaphragm being configured to reflect light from the further focused second beam of light, the diaphragm being disposed at the distal end of the second portion of the diaphragm housing to seal the lumen, the diaphragm housing and the diaphragm being a molded unitary piece, the diaphragm being deflectable in response to blood pressure in the range between 0 mmHg to at least 250 mmHg;
a second prism, the second prism being configured to refract light, the beam splitter being configured to receive the reflected second beam of light from the diaphragm and then direct the second beam of light from the diaphragm to the second prism, the second prism refracting the second beam of light from the diaphragm into a third beam of light;
a signal detector, the signal detector being configured to receive the third beam of light from the second prism and measure at least one property of light of the third beam of light; the light source, the first lens, the beam splitter, the wave plate, the second lens, the diaphragm housing, and the diaphragm being disposed along a first longitudinal axis;
the first prism, the beam splitter, and the second prism being disposed along a second longitudinal axis, the second longitudinal axis being orthogonal to the first longitudinal axis; and the reference detector and the signal detector being disposed along a third longitudinal axis, the third longitudinal axis being parallel to the second longitudinal axis and being orthogonal to the first longitudinal axis.

US Pat. No. 10,335,039

METHODS FOR STENT STRUT DETECTION AND RELATED MEASUREMENT AND DISPLAY USING OPTICAL COHERENCE TOMOGRAPHY

LIGHTLAB IMAGING, INC., ...

1. A method of generating a diagnostic representation of a blood vessel and a stent disposed therein, the method comprising:storing a set of intravascular measurements in a memory device, the set of intravascular measurements generated in response to an intravascular scan of the blood vessel and the stent disposed therein;
wherein the set of stored intravascular measurements comprises intravascular data, the intravascular data comprising one or more pullback frames and one or more angles of rotation;
generating a two dimensional representation of a segment of the blood vessel and the stent disposed therein, wherein the two dimensional representation is oriented relative to a pullback frame axis and an angle of rotation axis; and
displaying the two dimensional representation of the segment of the blood vessel and the stent disposed therein.

US Pat. No. 10,335,037

GLOBAL LONGITUDINAL STRAIN FROM CINE MAGNETIC RESONANCE IMAGES

Siemens Healthcare GmbH, ...

1. A method for computing global longitudinal strain from cine magnetic resonance (MR) images, the method comprising:receiving a cine MR image sequence comprising a series of long axis image frames of a subject's heart;
automatically detecting a plurality of landmark points in each MR long axis image frame;
determining a deformation field between every pair of long axis image frames based on the plurality of landmark points;
labeling myocardial pixels in one or more of the long axis image frames using a deep learning framework to yield one or more myocardium masks;
propagating the myocardium masks to each long axis image frame using the deformation field between each pair of long axis image frames to yield a plurality of masked long axis images;
performing a polar transformation on each of the masked long axis image frames to yield a plurality of polar long axis images;
computing contours of the myocardium in each polar long axis image frame using a shortest path algorithm;
calculating longitudinal strain at every pixel in the myocardium for the polar long axis image frames using the contours of the myocardium; and
computing global longitudinal strain by averaging the longitudinal strain at every pixel in the myocardium of the polar long axis image frames.

US Pat. No. 10,335,036

PULSED ULTRASOUND MODULATED OPTICAL TOMOGRAPHY USING LOCK-IN CAMERA

HI LLC, Los Angeles, CA ...

1. An ultrasound modulated optical tomography (UOT) system, comprising:an acoustic assembly configured for delivering ultrasound into a target voxel within an anatomical structure;
an interferometer configured for delivering sample light into the anatomical structure, whereby a portion of the sample light passing through the target voxel is scattered by the anatomical structure as signal light, and another portion of the sample light not passing through the target voxel is scattered by the anatomical structure as background light that combines with the signal light to create a sample light pattern, the interferometer further configured for combining reference light with the sample light pattern to generate an interference light pattern;
a controller configured for operating the acoustic assembly and the interferometer to pulse the ultrasound and the sample light in synchrony, such that only the signal light is frequency shifted by the ultrasound, the controller further configured for operating the interferometer to sequentially modulate the interference light pattern to generate a plurality of different interference light patterns;
a lock-in camera having an array of detectors configured for simultaneously detecting spatial components of each different interference light pattern, wherein each detector of the lock-in camera respectively stores a plurality of values in a plurality of bins of the lock-in camera representative of the respective spatial components of the interference light patterns, wherein the controller is configured for synchronizing operation of the acoustic assembly, the interferometer, and the array of detectors of the lock-in camera, such that the different interference light patterns are detected at specific points on a cycle of the ultrasound; and
a processor configured for determining a physiologically-dependent optical parameter of the target voxel based on the plurality of values stored in the bins of each detector.

US Pat. No. 10,335,035

SHIM COIL DEVICE AND A MAGNETIC RESONANCE COIL SYSTEM HAVING A SHIM COIL DEVICE

Siemens Aktiengesellschaf...

1. A magnetic resonance (MR) coil system, comprising:a local breast coil device comprising a local MR coil configured to obtain MR data from a breast of a patient in an MR imaging procedure;
a shim coil device comprising a housing having a contact surface adapted for placement beneath a prone patient in said MR scanner in which a homogenous basic magnetic field is produced that proceeds along a longitudinal direction of the patient, so that the contact surface bears against a patient surface of the patient adjacent to a breast of the patient, the patient comprising a body region next to the heart in which said basic magnetic field exhibits inhomogeneity;
said shim coil device comprising a plurality of shim coil elements situated in said housing so as to be adjacent to but not surround said breast, said shim coil elements being situated in said housing so that, when said contact surface bears against said patient surface, said plurality of shim coil elements proceed sequentially in a direction along the longitudinal direction of the patient;
said shim coil elements being configured to produce a compensating magnetic field having field lines in an orientation in which said field lines proceed relative to said basic magnetic field in said body region so as to compensate said inhomogeneity of said basic magnetic field in said body region during said MR imaging procedure of the breast, and in which said field lines proceed in said breast relative to said basic magnetic field so as to not alter said basic magnetic field in said breast during said procedure;
each shim coil element forming a plane that is situated at a distance beneath said contact surface and said patient surface, said plane having a center and each shim coil element having a shim coil axis that proceeds through said center perpendicular to said plane, with said shim coil axis oriented with an angle of inclination ? relative to at least one of said contact surface and said patient surface, with 45°???135°, so as to produce said orientation of said field lines of said compensating magnetic field; and
said local breast coil device and said shim coil device being situated in a sequence along said longitudinal direction of the patient.

US Pat. No. 10,335,031

VITALS MONITORING SYSTEM

Accenture Global Solution...

1. A system, comprising:a platform that includes one or more memory devices and one or more processors communicatively coupled to the one or more memory devices,
wherein the platform is to connect and communicate bi-directionally with a plurality of devices via a gateway device,
the gateway device being a user device associated with a patient,
the user device and the at least some of the plurality of devices being located in a same physical location,
wherein the plurality of devices includes different types of devices and devices manufactured by a plurality of different third parties,
wherein at least some of the plurality of devices include sensors capable of gathering vitals data from the patient,
wherein the vitals data includes a plurality of different types of vitals data,
wherein the platform is to support continuous and live streaming of the vitals data from the sensors,
wherein the platform is to:
receive threshold data on a per patient basis,
wherein the threshold data identifies a baseline for one or more of the plurality of different types of vitals data,
selectively generate an alert based on the vitals data and the threshold data, and
provide the alert to a responsible party when the alert is generated.

US Pat. No. 10,335,025

SYSTEM AND METHOD FOR THE TRAINING OF HEAD MOVEMENTS

Carl Zeiss Vision Interna...

17. A system to assist a spectacle wearer to learn to adapt and train his or her head movement behavior to progressive spectacles, the system comprising:a visual stimulus generation device including a screen and being configured to generate a visual stimulus on said screen for a left and a right eye of the spectacles wearer with the left and right eyes having respective rotation points;
a measurement device configured to capture a head movement of the spectacles wearer from a start head posture to an end head posture;
an assessment device including program code stored on a non-transitory computer readable medium for evaluating said head movement from the start head posture into the end head posture of the person to generate evaluation data directed to the head movement;
said evaluation data being dependent upon the visual stimulus and upon the head movement detected in response to the generated visual stimulus;
said program code including an evaluation routine configured to compare a first value for the head movement which is a desired value with respect to the generated visual stimulus to a second value for the head movement assigned to said visual stimulus wherein a displacement of the rotation points of the left and right eyes are captured in a person-specific coordinate system which is referred to a coordinate system of said visual stimulus generation device; and,
an output device configured to provide the evaluation data for the spectacles wearer so as to permit the spectacles wearer to learn how the spectacle wearer must change said head movement to see a clear picture through the spectacles.

US Pat. No. 10,335,023

ENDOTRACHEAL TUBE INSERTION DEVICE

1. An intubation assembly rod in combination with an endotracheal tube insertion device having an elongated insertion member, the intubation assembly rod movably attached to the endotracheal tube insertion device and configured for insertion into an endotracheal tube, such that the endotracheal tube is carried thereon, the intubation assembly rod comprising an elongated body having a distal end, a proximal end, and defining a first axis, wherein the distal end of the intubation assembly rod body is one of tapered, rounded, and spherical and defines a leading end of the intubation assembly rod, and wherein the intubation assembly rod includes a longitudinally extending channel defining a second axis parallel to the first axis and further defining a guide sleeve that extends radially outwardly from the intubation assembly rod body, the guide sleeve positioned intermediate the distal and the proximal ends of the intubation assembly rod body, the channel configured such that an elongated member of a flexible optical assembly may be inserted into the channel;wherein the flexible optical assembly member has an elongated body having a substantially cylindrical shape and a plurality of longitudinally extending conduits formed therein, the longitudinally extending conduits configured to have one or more of a first video imaging device and first light source disposed therein.

US Pat. No. 10,335,021

ENDOSCOPE WIPER BLADE CLEANER

Covidien LP, Mansfield, ...

1. A surgical instrument comprising:a viewing instrument including a lens; and
a wiper mechanism attachable to the viewing instrument, the wiper mechanism including:
a sheath configured to receive the lens therethrough; and
first and second cylindrical members operatively coupled to the sheath, wherein the first cylindrical member is rotatable about a longitudinal axis of the second cylindrical member extending along the length of the second cylindrical member when the lens extends distally through the sheath such that the first cylindrical member wipes the lens.

US Pat. No. 10,335,014

ENDOSCOPE SYSTEM, PROCESSOR DEVICE, AND METHOD FOR OPERATING ENDOSCOPE SYSTEM

FUJIFILM Corporation, To...

1. An endoscope system comprising:a light source device that generates illumination light to irradiate an observation object and is able to control an optical spectrum of the illumination light;
an image sensor which includes a blue pixel receiving light in a blue wavelength band, a green pixel receiving light in a green wavelength band, a red pixel receiving light in a red wavelength band, and a white pixel receiving at least light in a blue wavelength band and a green wavelength light, and images the observation object by reflected light of the illumination light from the observation object;
an imaging distance calculator which calculates an imaging distance which is a distance between the image sensor and the observation object;
a light source controller which increases a component of the blue wavelength band or the green wavelength band included in the illumination light according to the imaging distance; and
a demosaic processor configured to apply a first demosaic process performed with use of an image signal from the white pixel as a green image signal and a second demosaic process performed with use of an image signal from the white pixel as a blue image signal, the demosaic processor selectively applying the first demosaic process and the second demosaic process according to the imaging distance to an image signal which the image sensor outputs,
wherein signal value of the white pixel is used as the green image signal of the white pixel position in the first demosaic process, and is used as the blue image signal of the white pixel position in the second demosaic process, and
wherein the imaging distance calculator and the demosaic processor are implemented by a processor device.

US Pat. No. 10,335,010

DISH WASHER COMPRISING AN AUXILIARY ARM WITH STOPPERS

LG Electronics Inc., Seo...

1. A dishwasher comprising:a tub with a space configured to accommodate objects to be washed;
a sump that is mounted to a lower part of the tub and that is configured to store wash water;
a spray arm comprising:
a main arm accommodated in the tub and configured to spray wash water received from the sump, and
an auxiliary arm rotatably mounted to the main arm and configured to spray wash water to the objects; and
a power transfer assembly configured to operate the auxiliary arm using a rotary force of the main arm, the power transfer assembly configured to have a predetermined elastic force with respect to the auxiliary arm wherein the auxiliary am is elastically deformable within a predetermined angle range in a horizontal direction, the range formed between stoppers at both sides of the auxiliary arm.

US Pat. No. 10,335,002

HAND-HELD VACUUM CLEANER

JIANGSU MIDEA CLEANING AP...

1. A hand-held vacuum cleaner, comprising:a dust cup comprising a first cyclone, a cyclone assembly, and a filtration member, wherein
the first cyclone has an air intake channel having a first air intake and a first air vent, the cyclone assembly comprises a plurality of second cyclones arranged in parallel along a circumferential direction of the first cyclone, a guiding channel is defined between two of the plurality of the second cyclones, the guiding channel is in communication with the first air vent and an airflow is guided to an outer circumference of the cyclone assembly along a tangent line to a circumferential wall of the second cyclone adjacent to the guiding channel, each second cyclone has an air inducing notch to allow the airflow to enter the second cyclone in a tangent direction, each second cyclone is provided with an air guiding pipe, the air guiding pipe is spaced apart from an inner circumferential wall of the second cyclone, the air guiding pipe has an air guiding inlet and an air guiding outlet, the air guiding inlet is in communication with the air inducing notch,
the filtration member is disposed along the outer circumference of the cyclone assembly, the airflow in the outer circumference of the cyclone assembly tangentially enters the second cyclone through the filtration member and the air inducing notch; and
a housing having a first end provided with an air inlet and an air blowing vent wherein the dust cup is disposed within the housing and connected to the air inlet the air blowing vent is disposed adjacent to the air inlet.

US Pat. No. 10,334,999

TISSUE DISPENSING ASSEMBLY

1. A tissue dispensing assembly comprising:a first shell defining an interior space, said first shell comprising fabric, said first shell being configured for resembling an animal, said first shell being configured for resembling a bear;
a second shell defining an internal space, said second shell having an upper end, said upper end being open, said second shell being cylindrically shaped;
a first hole positioned in a top of said first shell;
a second hole positioned in a bottom of said first shell;
a panel coupled to and extending between a perimeter of said first hole and a circumference of said second hole defining a chamber in said interior space, said panel being resilient such that said chamber is positioned for expanding for inserting said second shell through said second hole into said chamber, wherein said second hole is positioned in said first shell such that said second hole is positioned for inserting said second shell into said chamber positioning said upper end of said second shell adjacent to said first hole, said panel comprising fabric, said panel comprising plastic;
a plurality of tissues, said plurality of tissues being rolled such that said plurality of tissues is configured for positioning in said internal space, wherein said plurality of tissues is positioned in said second shell such that a terminal sheet of said plurality of tissues is configured for positioning through said first hole such that said terminal sheet is configured for grasping in a hand of a user for extracting said terminal sheet from said internal space concurrent with positioning of an adjacent sheet through said first hole;
stuffing positioned in and substantially occupying said interior space between said panel and said first shell, said stuffing being resilient, said stuffing comprising polyester fill;
a first retainer coupled to said perimeter of said first hole, said first retainer being resilient, wherein said first retainer is positioned on said first shell such that said first retainer is positioned for substantially closing said first hole such that said first shell is in frictional contact with said adjacent sheet for promoting separation of said terminal sheet from said plurality of tissues, said first retainer comprising elastic;
a second retainer coupled to said circumference of said second hole, said second retainer being resilient, wherein said second retainer is positioned on said first shell such that said second retainer is positioned for expanding for inserting said second shell into and withdrawing said second shell from said chamber and for contracting for substantially closing said second hole, said panel being coupled to and extending between said first retainer and said second retainer, said second retainer comprising elastic;
a lid configured for selectively coupling to said top of said first shell for covering said first hole and said terminal sheet, said lid being top hat shaped;
a plurality of first couplers coupled to said top of said first shell proximate to said first hole;
a plurality of second couplers coupled to said lid, said second couplers being complementary to said first couplers, wherein said second couplers are positioned on said lid such that each said second coupler is positioned for selectively coupling to a respective said first coupler for coupling said lid to said first shell for covering said first hole and said terminal sheet, each said second coupler and said respective said first coupler comprising a hook and loop fastener, said plurality of first couplers comprising two said first couplers opposingly positioned and proximate to said perimeter of said first hole;
a disk positioned in said interior space and coupled to said top of said first shell, said disk comprising stiffened fabric such that said disk is semi-rigid, said disk comprising stiffened felt;
an orifice centrally positioned through said disk, said orifice being complementary to and aligned with said first hole, wherein said disk is positioned on said first shell such that said disk is positioned for preventing said first shell from being depressed proximate to said first hole; and
wherein said second retainer is positioned on said first shell such that said second retainer is positioned for expanding for inserting said second shell through said second hole into said chamber and for contracting for substantially closing said second hole, wherein said plurality of tissues is positioned in said second shell such that said terminal sheet of said plurality of tissues is configured for positioning through said first hole such that said terminal sheet is configured for grasping in the hand of the user for extracting said terminal sheet from said internal space concurrent with positioning of said adjacent sheet through said first hole, wherein said first retainer is positioned on said first shell such that said first retainer is positioned for substantially closing said first hole such that said first shell is in frictional contact with said adjacent sheet for promoting separation of said terminal sheet from said plurality of tissues, wherein said second couplers are positioned on said lid such that each said second coupler is positioned for selectively coupling to said respective said first coupler for coupling said lid to said first shell for covering said first hole and said terminal sheet.

US Pat. No. 10,334,998

FLEXIBLE CONTAINER AND REUSABLE CLOSURE ELEMENT

1. An assembly for providing a choice of closing systems, said assembly comprising:(a) at least one flexible container which comprises:
(i) a pouch formed from a flexible sheet material, said pouch having one or more walls that define and enclose an interior space;
(ii) a dispensing opening in at least one of the walls of said pouch, through which the interior space is accessible, said dispensing opening being delimited by a border;
(iii) a sealing area substantially surrounding said dispensing opening, the sealing area including a non-permanent adhesive material;
(iv) a releasable flexible sealing member for sealing said dispensing opening, the releasable flexible sealing member covering the dispensing opening and being releasably attached to the sealing area by the non-permanent adhesive material;
(v) a plurality of separable sheets present in said interior space;
(b) a rigid closure element comprising:
(i) a base having a top surface and a bottom surface, an outer rim and an inner rim;
(ii) a dispensing aperture defined by the inner rim of the base; and
(iii) a lid for sealing the dispensing aperture;
wherein the sealing area, the releasable flexible sealing member and the base of the closure element are configured such that the releasable flexible sealing member covers the sealing area prior to removal of the releasable flexible sealing member from the container; removal of the releasable flexible sealing member from the container exposes the sealing area and the non-permanent adhesive material thereof, and the base of the closure element may be adhered to the container via the non-permanent adhesive, to substantially cover the sealing area upon appropriate superimposition thereover, following removal of the releasable flexible sealing member from the container;
wherein the sealing area is delimited by an outer perimeter line and an inner perimeter line, wherein the outer perimeter line is spaced from the outer rim of the base by a distance of between 0 and 10 mm when the closure element is superimposed on the sealing area;
wherein the closure element comprises an outer perimeter line;
wherein the outer perimeter line of the sealing area forms generally the same shape as the outer perimeter line of the closure element;
wherein the inner perimeter line of the sealing area is spaced from the inner rim of the base by a distance of between 0 and 10 mm when the closure element is superimposed on the sealing area;
wherein the non-permanent adhesive material is uniformly applied in the sealing area;
wherein the inner perimeter line of the sealing area is spaced from the border of the dispensing opening by a distance of between 0.4 mm and 4 mm;
wherein the releasable flexible sealing member is part of the flexible sheet material forming said pouch; and
wherein the non-permanent adhesive material is a colored adhesive material.

US Pat. No. 10,334,992

ROTARY UNIT FOR SELECTIVELY ADDING ADDITIVES TO WATER IN A CONVENTIONAL BATHTUB AUTOMATICALLY

1. A rotary unit for selectively adding additives to water in a bathtub automatically without a bather having to touch the additives or leave the bathtub to get the additives, comprising:a) a plurality of pressurized canisters; and
b) a controller;
wherein said plurality of pressurized canisters are configured in a circular configuration;
wherein said plurality of pressurized canisters are for disposing directly adjacent to, and communicatable with, the bathtub;
wherein each pressurized canister is for containing a different one of the additives; and
wherein the controller is in communication with said plurality of pressurized canisters, and as such, said controller is utilized for choosing one of the additives to add to the water in the bathtub automatically.

US Pat. No. 10,334,991

COMBINATION CUTTING AND STRAINING APPARATUS

1. A combination cutting and straining apparatus, comprising:a cutting board having a top surface and a bottom surface opposite said top surface and having a planar configuration, said cutting board having first and second side edges;
wherein said bottom surface of said cutting board defines first and second grooves that are proximate and extending parallel to said first and second side edges, respectively;
a strainer basket having a bottom wall that is impermeable and a plurality of walls extending upwardly from peripheral edges of said bottom wall, respectively, for defining an interior straining area, each wall of said plurality of walls being permeable and defining a plurality of holes operable for water to pass through;
wherein said plurality of walls includes first and second side walls having first and second upper edges, respectively, that are selectively received in said first and second grooves, respectively, and operable for slidable movement of said cutting board atop said strainer basket.

US Pat. No. 10,334,990

CUTTING BOARD WITH REMOVABLE DRIP PAN SYSTEM

1. A system, comprising:a cutting board that includes:
a top surface, a bottom surface, a front edge, a back edge, and a pair of opposing sides, one or more channels disposed along the top surface, wherein a bottom surface of the one or more channels is positioned below the top surface of the cutting board,
at least one aperture that extends from the top surface to the bottom surface, and
a pair of guides that are disposed along the bottom surface of the cutting board at a location adjacent to the pair of opposing sides;
a ledge that is positioned on the bottom surface of the cutting board and extending along an entirety of the back edge between the pair of opposing sides;
a spacer that is secured along a central portion of the ledge; and
a waterproof drip pan having a bottom surface, a raised outer wall, and a pair of edges, wherein the pair of guides are configured to engage the pair of edges to position the drip pan beneath the bottom surface of the cutting board and each of the at least one aperture.

US Pat. No. 10,334,987

SYSTEMS AND METHODS FOR A MIXING CONTAINER

1. A disposable mixing system comprising:a lid comprising an opening and configured to hold contents within a container;
a strainer configured to couple with the container and the lid in a position between the container and the lid, wherein the strainer mixes the contents responsive to shaking the container; and
a cap configured to cover the opening of the lid;
wherein at least the lid and the strainer are formed in a unified piece wherein the strainer is configured to snap onto a perimeter of the container;
wherein the strainer is coupled to the lid via a first unifying projection and/or the cap is coupled to the lid and/or the strainer via a second unifying projection, the first and/or the second unifying projection comprising notches.

US Pat. No. 10,334,985

DISPOSABLE GRILL CLEANING DEVICE

Qloud Products LLC, Orla...

1. A grill cleaning device, comprising:a main body that is constructed from a grease absorbing material and includes a top surface having an outer perimeter, a bottom surface, and a plurality of side walls extending upward along an entirety of the outer perimeter;
a handle that extends upward from a center of the top surface of the main body, said handle being positioned equidistantly between the plurality of side walls;
a first plurality of elongated channels that are disposed along the bottom surface in a first direction; and
a second plurality of elongated channels that are disposed along the bottom surface in a second direction that is not parallel to the first direction.

US Pat. No. 10,334,981

METHOD AND DEVICE FOR PREPARING BEVERAGES

KONINKLIJKE PHILIPS N.V.,...

1. A beverage preparation device comprising:a module for dividing raw material(s) of the beverage into said several ingredients;
a plurality of storage chambers for storing several ingredients, respectively, each of said several ingredients having a different taste property;
a user interface for receiving data representing a user's preferred taste;
a taste management unit comprising:
a memory for storing a reference table which describes the taste property of each ingredient, and
a processor for determining the dosage of each ingredient to be used according to said reference table and the user's preferred taste;
a generator for generating a beverage from at least one of said several ingredients according to said determined dosage; and
wherein at least one of:
said module for dividing raw material(s) comprises a cutter for cutting a single raw material into said several ingredients, and
said module for dividing raw material(s) comprises at least one taste sensor by means of which the raw material(s) of the beverage are accurately divided into said several different ingredients.

US Pat. No. 10,334,973

ADJUSTABLE AND MOUNTABLE GALLERY DEVICE

ABK INNOVATIONS LLC, Gal...

1. A gallery apparatus, comprising:a pair of main supports extending in a first direction with respect to a surface, each main support having a main support cord terminated by first and second main support terminal ends that respectively couple to surface attachments associated with the surface so as to mount the pair of main supports to the surface; and
at least one item support extending in a second direction with respect to the surface and between the pair of main supports, the at least one item support having opposed ends respectively having item support terminal ends for coupling the at least one item support to the pair of main supports,
wherein the second direction is transverse to the first direction,
wherein the at least one item support is configured to provide an attachment point to support an item for display, and
wherein each item support terminal end of the at least one item support comprises:
a cord stop having an aperture;
a button having an opening and coupled to a spring, wherein compression of the spring via application of a force on the button aligns the aperture and the opening so as to enable the main support cord of one of the pair of main supports to pass through;
a neck portion defining a channel configured to receive a terminal end of an item support cord forming the item support; and
a sleeve configured to slide over the neck portion and secure the terminal end of the item support cord within the channel.

US Pat. No. 10,334,972

MODULAR POSTER PRINT STRETCH FRAME

1. A modular poster print stretch frame, comprising:a plurality of side sections;
a plurality of corner sections;
a plurality of connectors; and
a plurality of retaining structures disposed on the plurality of side sections,
wherein the plurality of side sections and the plurality of corner sections form a closed loop, and the plurality of side sections and the plurality of corner sections are connected via the plurality of connectors, and
wherein a fabric sheet is retained by the plurality of retaining structures; and
wherein the plurality of retaining structures comprise in part a plurality of lips disposed on the plurality of side sections, each lip being disposed apart from other retaining structures in the plurality of retaining structures and along an edge of the side section, wherein each lip is configured to be taller than the other retaining structures and wherein the fabric sheet is retained by stretching around the plurality of lips to couple to the other retaining structures.

US Pat. No. 10,334,966

INTERLOCKING PANELS, MODULES WITH INTERLOCKING PANELS, AND A MODULAR DISPLAY CASE WITH INTERLOCKING MODULES WITH INTERLOCKING PANELS

1. A method for removably connecting interlocking panels together, comprising:providing a first panel member having a ball key tab, the ball key tab including a ball key retaining aperture defined in the ball key tab;
inserting a ball key in the ball key retaining aperture;
providing a second panel member including a generally rectangular ball key tab connecting port for removably receiving the ball key tab and the ball key; and
removably interconnecting the first panel and the second panel by inserting the ball key tab and the ball key into the generally rectangular ball key tab connecting port.

US Pat. No. 10,334,965

MONITORING DEVICE, MONITORING SYSTEM, AND MONITORING METHOD

PANASONIC INTELLECTUAL PR...

1. A monitoring device comprising:a processor that:
sets an area of a part of a display shelf to be monitored as a fixed area, based on a captured image of the display shelf in a store, the fixed area being an area whose image is not to be changed over time;
stores the fixed area in the monitoring device;
determines a similarity between an image of the stored fixed area and an image at the same position as the fixed area in a captured image of the store;
detects that a position of the display shelf is changed in the captured image of the store, when it is determined that there is no similarity between the image of the fixed area and the image at the same position as the fixed area in the capture image of the store; and
notifies a user that the display shelf to be monitored is not detected, when it is detected that the position of the display shelf is changed.

US Pat. No. 10,334,960

DROP-IN OCCUPANCY DETECTION COMPONENT FOR FURNITURE

1. An occupancy detection system comprising:a frame;
a control component associated with an automated furniture item, the automated furniture item including a cavity corresponding to the frame, the control component comprising a receiving component and a determining component; and
a detection array component adapted to be coupled to the automated furniture item, the detection array component comprising:
(1) one or more sinuous wires coupled to the frame, and
(2) one or more bridging components coupled to the one or more sinuous wires along the frame and the control component, wherein the one or more bridging components are configured to generate a capacitive array associated with the one or more sinuous wires, said capacitive array configured to monitor a change in capacitance with respect to the detection array component.

US Pat. No. 10,334,959

AIR MATTRESS HAVING INFLATING AND DEFLATING FUNCTIONS

PARAMOUNT BED CO., LTD., ...

1. A control method for an air mattress having inflating and deflating functions, the air mattress comprising:a plurality of air cells, the air cells being arranged in parallel in a bed longitudinal direction;
a pump configured to perform air supply and air discharge for each of the air cells; and,
control circuit configured to control air pressure inside the air cells by the pump,whereinthe control method comprising the steps of:setting an output of the pump at a first output equal to or lower than a maximum output when the pump inflates the air cells from a state in which the air cells are pressureless to a normal use state; and
setting a maximum power of the pump when the air cells are selectively and alternately inflated and deflated at a second output lower than the first output.

US Pat. No. 10,334,958

GLUELESS POCKETED SPRING ASSEMBLY WITH IMPROVED AIRFLOW

1. A bedding or seating product comprising:a pocketed spring assembly comprising first and second sheets of fabric and rows of springs between the first and second sheets of fabric, the first and second sheets of fabric being joined by longitudinal seams to separate adjacent rows of springs into strands, longitudinal seams separating each row of springs from an adjacent row of springs, a plurality of pockets formed along each strand of springs by aligned first and second linear separating seams, each of the first linear separating seams joining said first sheet to itself and extending downwardly from an ear between adjacent pockets and terminating at a first end, each of the second linear separating seams joining the second sheet to itself and extending upwardly from an ear between adjacent pockets and terminating at a second end and at least one spring positioned in each said pocket, a distance between the first and second ends of aligned first and second separating seams defining a height of a gap having a diamond-shaped configuration allowing air to flow through pockets, the gap having a width between longitudinal seams on opposite sides of a strand;
cushioning materials; and
a covering encasing said pocketed spring assembly and cushioning materials.

US Pat. No. 10,334,947

SINK SHELF

KOHLER CO., Kohler, WI (...

1. A sink shelf assembly comprising:a first shelf member configured to mount underneath a sink and comprising a front surface, a back surface, two side surfaces interconnecting the front and back surfaces, and a recess extending inwardly from the back surface between the two side surfaces; and
a second shelf member removably received in the recess of the first shelf member in a coupled position and removed from the recess in a decoupled position to allow routing of plumbing through the recess without obstruction from the first shelf member;
wherein the second shelf member includes two side surfaces that are detachably coupled to two inner side surfaces of the first shelf member in the coupled position, and wherein the two inner side surfaces define at least part of the recess;
wherein the second shelf member includes a back surface that is flush with the back surface of the first shelf member in the coupled position, and wherein the recess is located substantially centrally between the two side surfaces of the first shelf member;
wherein an outer perimeter of the second shelf member has a shape that complements a shape of the recess of the first shelf member;
wherein the outer perimeter of the second shelf member has a bullet shape having a rounded front surface extending from the two side surfaces of the second shelf member, which are parallel.

US Pat. No. 10,334,945

MODULAR RACK FOR PHYTOCHEMICAL EXTRACTION SYSTEM

1. A modular rack, comprising:a first leg having a vertical member attached to a horizontal member;
a second leg having a vertical member attached to a horizontal member; and
a variable width frame comprising one or more frame modules, wherein each frame module is rectilinear in shape, wherein each frame module has a left side and a right side, wherein each frame module is W1 units of distance wide, wherein each side of each frame module is attachable to a side of another one of the frame modules or to a top end of the vertical member of one of the first leg or second leg,
such that the variable width frame is configurable to provide the modular rack with a width of N units of distance by combining the first leg, second leg, and M frame modules, wherein N=M*W1, wherein M is the total number of frame modules in the modular rack, and
wherein each of the frame modules includes an upper mounting device and a lower mounting device that are each configured to removably attach an extraction column to the frame module, wherein each mounting device comprises a hole in the frame module, wherein the extraction column includes a flat plate member having a hole that is configured to be aligned with the frame hole and that is configured to receive a bolt that passes through the member hole and the frame hole, thereby removably coupling the extraction column to the frame module.

US Pat. No. 10,334,942

SOAP DISPENSING BRUSH

1. A soap dispensing brush, comprising:a handle having a first end, a second end, and an interior volume configured to store liquid cleaner therein;
an end cap removably secured to the second end of the handle;
wherein the end cap comprises at least one exterior air vent in fluid communication with at least one interior opening disposed on the end cap;
wherein at least one flap is hingedly affixed to the end cap, the flap configured to selectively move between a closed position and an open position when the end cap is depressed, wherein the flap covers the interior opening when in the closed position;
a brush head disposed on the first end of the handle, the brush head comprising a first side and a second side, the first side having a plurality of bristles thereon;
a plurality of apertures disposed on the first side of the brush;
a push rod having a first end in contact with the end cap and a second end in contact with a valve;
wherein the valve is configured to open when the end cap is depressed;
and whereby opening of the valve dispenses liquid from the plurality of apertures.

US Pat. No. 10,334,941

BOTTLE BRUSH WITH MULTIPLE BRISTLE REACHES

Handi-Craft Company, St....

1. A bottle brush comprising:a handle; and
a brush head connected to the handle, the brush head having a longitudinal axis and further comprising
a barrel having a sidewall substantially parallel to the longitudinal axis,
a first row of bristles extending from the sidewall, wherein the first row of bristles is biased a first angle from a plane normal to the longitudinal axis to extend from the sidewall at least in part transversely from the barrel and at least in part longitudinally to define a first bristle reach, and
at least two second rows of bristles extending from the sidewall, wherein the at least two second rows of bristles are each biased a same second angle from the plane normal to the longitudinal axis to extend from the sidewall at least in part transversely from the barrel and at least in part longitudinally, each of the second rows of bristles defining a second bristle reach different from the first bristle reach, the at least two second rows of bristles being spaced longitudinally from each other with the first row of bristles being longitudinally intermediate the second rows of bristles.

US Pat. No. 10,334,922

POCKETED ARTICLE AND METHOD OF MAKING THE SAME

Amer Sports Canada Inc., ...

1. A pocketed article comprising:a first primary panel;
a liner panel having a first face bonded to the first primary panel and a second face opposite the first face of the liner panel;
a secondary panel having a first face facing the second face of the liner panel and a second face opposite the first face of the secondary panel, wherein outer portions of the liner panel are folded about edges of the secondary panel and wherein the outer portions are bonded to the second face of the secondary panel; and
a second primary panel joined to the first primary panel.

US Pat. No. 10,334,920

UMBRELLA HOLDER AND STABILIZATION SYSTEM

1. An umbrella holder and stabilization system for hands-free holding of an umbrella of a type having a pole, a canopy, shaft, and a crook handle, said umbrella holder and stabilization system, comprising:a housing having a bottom wall and a plurality of side walls extending upwardly from said bottom wall that, collectively, define an interior space, said housing having a top wall spanning between upper edges of said plurality of side walls and defining an opening operable for receiving the crook handle of the umbrella into the interior space;
a neck strap member having a first end and a second end opposite said first end and a neck strap fastener coupling said first end to said second end so that said neck strap member is a loop;
at least one clamp slidably coupled to said neck strap member having a configuration that is slidable along an extent of said neck strap member and is operable to releasably capture the pole of the umbrella;
wherein said housing includes a fastener operably coupled to said neck strap for coupling said housing to said neck strap member.

US Pat. No. 10,334,917

PENDANT ADAPTER FOR INTERLOCKING BUILDING TOY

1. A multi-functional pendant includinga plurality of interlocking toy pieces and an interchangeable adaptor for converting said plurality of interlocking toy pieces into said multi-functional pendant,
each said interlocking toy piece comprises at least one protruding stud on one side and at least one depression notch on a different side of said interlocking toy piece, said at least one protruding stud of each one of said interlocking toy pieces is removably engageable, by an interference fit, with said at least one depression notch on any other of said interlocking toy pieces; and,
said interchangeable adaptor comprises at least one fastener shaped to fit into a space defined around said at least one protruding stud, said at least one fastener is made of a piece of material sufficiently thinner than a thickness of said at least one protruding stud for enabling said at least one fastener to be firmly clamped between at least two of said interlocking toy pieces when the at least one protruding stud has been engaged, by an interference fit, with said at least one depression notch; and, wherein said interchangeable adaptor further comprises at least one aperture for connecting the multi-functional pendant to a variety of accessories.

US Pat. No. 10,334,909

ELASTIC SHOELACE WITH A RING

1. An elastic shoelace comprising:a knot (3) located at one end of the elastic shoelace;
a circular eye (2) located opposite the knot at an other end of the elastic shoelace;
a ring (5) that is received by and located on the eye (2); and
a tag (6) provided on the ring;
wherein the elastic shoelace is inserted with the eye (2) through a set of holes (B) in a lower section of a shoe (A) upwards and once the elastic shoelace is secured in the set of holes (B) in the shoe (A), the knot (3) is fixed behind a first bottom hole (B) of the shoe (A) and the ring (5) is hooked onto an adequate threaded pin (4) arranged on the shoe (A).

US Pat. No. 10,334,904

SPORTS HELMET WITH ROTATIONAL IMPACT PROTECTION

BAUER HOCKEY, LLC, Blain...

1. A hockey or lacrosse helmet for protecting the head of a player, the hockey or lacrosse helmet comprising:(a) a rigid outer shell defining an external surface of the helmet, the rigid outer shell comprising a plurality of shell members movable relative to one another to adjust the fit of the helmet on the player's head;
(b) an inner padding configured to conform to the head of the player, the inner padding being configured to decrease a radial acceleration of the head of the player as a result of a radial impact acting against the outer shell, said inner padding comprising a plurality of inner pad members, the inner pad members being associated with respective ones of the shell members so that when the shell members move relative to one another a corresponding movement is imparted to the associated inner pad members;
(c) a rotational impact cushioning arrangement comprising at least one thin and flexible piece of damping material configured to reduce a rotational acceleration of the head of the player as a result of a rotational impact acting against the outer shell, the thin and flexible piece of damping material having a main surface and a thickness, the main surface having an extent that is greater than the thickness, the thin and flexible piece of damping material residing at a location which is adjacent the head of the player when the helmet is worn and the main surface being oriented towards the head of the player when the helmet is worn, the location of the thin and flexible piece of damping material being such that displacement of the shell members relative to one another produces a movement of the thin and flexible piece of damping material relative to at least one of the inner pad members, wherein the thin and flexible piece of damping material is configured such that a rotational impact on the outer shell induces a lateral distortion of the thin and flexible piece of damping material in a direction along the main surface thereof; and
(d) an adjustment mechanism operable by the player and configured to allow the shell members to move relative to one another to perform an adjustment of the fit of the helmet on the player's head.

US Pat. No. 10,334,903

RETRACTABLE DISPLAYS FOR HELMETS

Intel Corporation, Santa...

1. A helmet comprising:an outer shell;
a heads-up information system comprising a display, the heads-up information system movable from a storage position within the outer shell to a use position in which the display of the heads-up information system is visible by the user, when the helmet is worn by the user; and
an attachment assembly coupled to the outer shell and the heads-up information system and operable to move the heads-up information system between the storage position and the use position;
wherein, the axis of movement from the use position to the storage position is something other than an axis normal to the plane of the user's vision.

US Pat. No. 10,334,891

BRASSIERE WITH A CONCEALING ELEMENT

1. A brassiere comprising:cups, each cup having at least one frame,
straps, each strap connecting to a cup at an apex,
a bottom band, and
elements configured to cover a wearer's breast tip region, wherein the elements are respectively arranged on a cup's inner side that faces a wearer's body, and the elements only partly cover the cups' inner side facing the wearer's body, and the elements are connected to the brassiere in at least three positions, at least one of the positions being the apex, and the remaining positions including one or more frames of the cup, the strap, or the bottom band.

US Pat. No. 10,334,888

ELECTRONIC VAPORIZING DEVICE FOR VAPORIZING WATER-BASED COMPOSITIONS

LunaTech, LLC, Encino, C...

1. A personal vaporizer comprising:a device processor operable for controlling the personal vaporizer, wherein the device processor is operable to generate an activation command to initiate a vaporization process;
at least one container configured to store a water-based vaporizable liquid composition;
an ultrasonic vaporizing component operatively coupled to the device processor and controlled in part by the device processor, wherein the ultrasonic vaporizing component is in fluid communication with the at least one container for receiving at least a portion of the selected amount of the vaporizable liquid composition from the at least one container, wherein the ultrasonic vaporizing component comprises an ultrasonic vibration element operable to produce ultrasonic vibrations to vaporize at least a portion of the vaporizable liquid composition received therein;
a vapor outlet coupled to the ultrasonic vaporizing component and configured to receive a vapor generated by the ultrasonic vaporizing component, the vapor outlet operable to expel the generated vapor from the ultrasonic vaporizing component;
an input/output device operatively coupled to the device processor; wherein the input/output device is configured to receive a plurality of data for transmission to the device processor, wherein the input/output device is configured to transmit a plurality of data generated by the device processor; and
a power source operatively coupled to the ultrasonic vaporizing component, wherein the at least one power source is operable to generate a supply of power for operation of the ultrasonic vaporizing component;
wherein the device processor is further operable to,
receive a plurality of device activation parameters for controlling activation of the vaporization process;
generate at least one device activation control signal in accordance with at least a portion of the plurality of device activation parameters; and
transmit the at least one device activation control signal to the ultrasonic vaporizing component to initiate the vaporization process in accordance the at least one device activation control signal.

US Pat. No. 10,334,887

ATOMIZER AND ELECTRONIC CIGARETTE

JOYETECH EUROPE HOLDING G...

1. An atomizer comprising:a storage member; and
a cigarette holder;
wherein an inductive chamber and an airflow passage are separately defined in the storage member, an air suction port is defined on the cigarette holder, the cigarette holder is movably sleeved on an end of the storage member, the cigarette holder can alternate between a locked state and an unlocked state with respect to the storage member by moving the cigarette holder; when the cigarette holder is in the locked state, at least one of the inductive chamber and the airflow passage is closed by the cigarette holder; when the cigarette holder is in the unlocked state, the air suction port communicates with both of the inductive chamber and the airflow passage.

US Pat. No. 10,334,884

AEROSOL GUIDING DEVICE AND AEROSOL GENERATING SYSTEM COMPRISING SAID AEROSOL GUIDING DEVICE

JT International S.A., (...

1. An aerosol generating system, the system comprising:aerosol generating means;
aerosol delivery means; and
an aerosol guiding device,
wherein the aerosol guiding device comprises a chamber having an air inlet, an air outlet, an upstream portion that tapers inwardly from the air inlet, and a downstream portion that tapers inwardly from the air outlet, the aerosol delivery means being configured such that aerosol is introduced from the aerosol generating means into the chamber in use, and
wherein an airflow route is defined from the air inlet to the air outlet, and the relative dimensions of the air inlet and the air outlet are selected to provide pressure control means for controlling the pressure differential between the air inlet and the air outlet.

US Pat. No. 10,334,882

ELECTRONIC CIGARETTE

1. An electronic cigarette, comprising:a base part; and
a cartridge configured to be assembled to the base part;
wherein said base part includes a battery and at least one heating element connected to the battery;
wherein said cartridge includes:
a substance chamber configured for containing therein a substance to be smoked, said substance chamber comprising a substance outlet;
a vaporization chamber in communication with the substance outlet for receiving said substance therein; and
at least one heat transfer unit configured, at least when the cartridge is assembled to the base part, for being heated by the at least one heating element of the base part and for heating the substance being provided via said substance outlet for its vaporization in the vaporization chamber; and
wherein, when the cartridge is assembled to the base part, the at least one heating element is separated from the vaporization chamber by the heat transfer unit.

US Pat. No. 10,334,866

HANDHELD ASSEMBLY AND METHOD FOR UNIFORM DECORATION OF THE SIDEWALL FOR FOODSTUFF

1. An assembly for uniform decoration of sidewall for baked foodstuff, the assembly comprising:a spray gun comprising:
a housing defined by a rear end, a middle portion forming an upper inlet, and a front end terminating at an outlet;
a conduit coaxially and longitudinally disposed through the housing from the rear end to the front end, the conduit in communication with the upper inlet of the housing;
a container comprising an end wall and a continuous sidewall extending from the end wall and terminating at an opening, the end wall and the continuous sidewall defined by a cavity, the container configured to join with the middle portion of the housing such that the opening of the container is in communication with the upper inlet of the housing;
a regulation valve operational to variably open and close the communication between the opening of the container and the upper inlet of the housing;
a fan disposed at the rear end of the housing, the fan configured to generate air flow through the conduit from the rear end to the outlet at the front end of the housing;
at least one switch operatively connected to the fan, or the regulation valve, or both, the at least one switch configured to control the rate of the fan, or the position of the regulation valve, or both the rate and the position;
a plurality of dispensing tips detachably attachable to the outlet at the front end of the housing, the plurality of dispensing tips configured to create different shapes or discharge patterns for the plurality of decorative granular members;
the container configured to supply edible decorative granular members; and
at least one shield, the at least one shield operational with the spray gun, the at least one shield configured to selectively position in front of the outlet of the spray gun.

US Pat. No. 10,334,849

SALTS OF CARBOXYLIC ACID HERBICIDES

Monsanto Technology LLC, ...

1. A herbicide salt comprising an anion of an auxin herbicide and a cation of a compound selected from the group consisting of:(a) Formula I:
wherein R1 is substituted or unsubstituted C1-C20 alkyl, substituted or unsubstituted C1-C20 alkanol, substituted or unsubstituted C5-C20 cycloalkyl, substituted or unsubstituted C3-C20 heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl, and R2 and R3 are independently hydrogen or substituted or unsubstituted hydrocarbyl;(b) Formula II:
wherein R4 and R5 are independently hydrogen or substituted or unsubstituted hydrocarbyl, provided that when R5 is hydrogen or an unsubstituted C1-C6 alkyl, then R4 is not an aminoalkyl or when R4 is hydrogen or an unsubstituted C1-C6 alkyl, then R5 is not an aminoalkyl;(c) Formula III:
wherein R6 is hydrogen, substituted or unsubstituted C1-C20 alkyl, substituted or unsubstituted C1-C20 alkanol, substituted or unsubstituted C5-C20 cycloalkyl, substituted or unsubstituted C3-C20 heterocycloalkyl, substituted or unsubstituted aryl, substituted or unsubstituted alkylaryl, or substituted or unsubstituted heteroaryl and R7 is hydrogen, oxo, or unsubstituted or substituted hydrocarbyl, provided that when R6 is an unsubstituted C1-C6 alkyl, then R7 is not an aminoalkyl or when R7 is hydrogen or an unsubstituted C1-C6 alkyl, then R6 is not an aminoalkyl;(d) Formula IV:
wherein n is from 1 to about 20, from 1 to about 10, from about 3 to about 10, or from about 3 to about 6 and R8 and R9 are independently any substituent as defined for R7;(e) Formula V:

wherein X is O, NR10 or S and R10 is hydrogen or C1-6 alkyl; and tautomers and mixtures thereof.

US Pat. No. 10,334,838

DEADFALL TRAP APPARATUS AND METHOD

1. A deadfall trap apparatus for capturing an animal for survival, comprising:a body portion;
the body portion comprising a channel having first and second spaced apart walls connected by a web;
a trigger pivot point aperture, the trigger point aperture extending through both walls of the body portion;
a load support pivot point aperture extending through both walls of the body portion;
a pivoting trigger release;
the pivoting trigger release further comprising a trigger pivot point pin pivotably carried in the trigger pivot point aperture on the spaced apart walls of the body portion;
a releasable trigger element in contact with the pivoting trigger release when the deadfall trap apparatus is “set” and the releasable trigger element not in contact with the pivoting trigger release when the deadfall trap is “tripped”;
a pivotable load support having a length from one end of the pivotable load support to a second end of the pivotable load support, the pivotable load support having a load support pivot point aperture and a load support pivot point pin carried in the load support pivot point aperture;
the pivotable load support pivot point pin pivotably carried in the pivotable load support pivot point apertures formed in the spaced apart walls of the body portion of the deadfall trap apparatus; and
a linkage rod connecting the releasable trigger element to a linkage attachment point at one end of the pivotable load support.

US Pat. No. 10,334,834

FISHING TOOL ASSEMBLY

1. An assembly, comprising:a lower lever having a first end and a second end;
the first end of the lower lever has a slot configured to receive a fishing line;
the first end of the lower lever has an aperture which extends through a surface of the lower lever toward the slot; and
an upper lever having a first end and a second end;
the first end of the upper lever has a tooth integrally formed thereon, the tooth of the upper lever extending in a direction of the lower lever;
wherein the upper lever is configured to rotate around an axis of a hinge which connects the upper lever to the lower lever;
wherein the tooth of the upper lever is configured to pass through the aperture of the lower lever, when the second end of the upper lever is rotated in a downward direction toward the second end of the lower lever, to compress a fishing sinker from an open position to a closed position around the fishing line.

US Pat. No. 10,334,831

FISHING NET AND METHOD OF MANUFACTURING SAME

Drifter Marine, Inc., Pe...

1. A fishing net comprising:a hoop formed of a section of tubing bent to a loop-like configuration, the hoop defining a net opening;
an elongate handle secured to the hoop at a proximal portion of the hoop; and
a net bag supported on the hoop;
wherein the hoop is hollow and is formed with a cross-sectional profile that varies in shape along at least a portion of the length of the section of tubing.

US Pat. No. 10,334,826

THUMB SUPPORTED ANIMAL TRAINING LEASH

1. A method of using a thumb supported leash, the method comprising:coupling a clasp of the thumb supported leash to a collar or a harness of an animal, the thumb supported leash comprising:
a thumb tab grip having a first end and a second end, the thumb tab grip is formed of a single piece of material that is folded over and coupled together to form a single aperture located at the first end between the pieces of material and the coupled portion forming the second end of the thumb tab grip;
a lead portion having a first end and a second end; and
a clasp, wherein:
the aperture located at the first end of the thumb tab grip includes a size to receive one thumb there through;
the second end of the thumb tab grip is coupled to the first end of the lead portion; and
the second end of the lead portion is coupled to the clasp;
receiving a thumb of a hand through the single aperture of a thumb tab grip of the thumb supported leash;
extending a second end formed of the coupled portions of material of the thumb tab grip across a palm of the hand; and
securing the thumb tab grip in response to grasping the second end of the thumb tab grip between the remaining fingers and the palm of the hand, wherein all material forming the thumb tab grip is around a thumb or between the remaining fingers and the palm of the hand.

US Pat. No. 10,334,821

RAINCOAT FOR DOGS

1. A raincoat (100) for dogs (200), comprising:a body portion (10) that substantially covers and extends from a rump (210) to a head (220) of a dog (200), wherein the body portion (10) is waterproof and the body portion (10) comprises a front edge (11), first and second front side edges (12 and 13), first and second side edges (14 and 15) and a rear edge (16);
a visor (20) fixedly attached to the front edge (11) of the body portion (10);
first and second pliable metal wires (31 and 32) that are parallel to each other and attached to the body portion (10) along a spinal line (230) of the dog (200), wherein the first and second pliable metal wires (31 and 32) substantially extend continuously from the front edge (11) of the body portion (10) to the rear edge (14) of the body portion (10); and
a fastening means (50) for fastening and securing the raincoat (100) to the dog (200).

US Pat. No. 10,334,820

METHOD FOR DISPLAYING INFORMATION ON AN ANIMAL AND FOR LOCATING AN ANIMAL

1. A method for locating an animal on which a display apparatus is arranged, and/or for displaying information on the animal, wherein information which is to be displayed is activatable and/or adjustable in and/or on the display apparatus (2), wherein a specific display is assigned to an animal in order to identify animals for selection, wherein a pushbutton key on the display apparatus (2) is used for acknowledgement by a user, and wherein a counterweight (8) is assigned to the display apparatus (2).

US Pat. No. 10,334,790

SUBSTRATE AUTO-PAVER FOR TABLE-TOP CULTURE

JIANGSU UNIVERSITY, Jian...

1. A substrate auto-paver for table-top culture machines for packing materials, transportation, and paving, the substrate auto-paver comprising the following components:a moving car, an automatic oblique pulling-type substrate-packing device, a substrate box, a substrate material in a cabinet, a floating-support-type double-side blanking device, and a uniform discharging device; a matrix box installed on the moving car, and a diagonal matrix automatic boxing device installed in the back side of the matrix box; the matrix box is installed between the substrate material in the cabinet and the double-side blanking device; the uniform discharging device is installed below the double-side blanking device;
the substrate material in the cabinet includes a bending-type scraper feeder, a dc motor, and a thin tension wheel; the bending-type scraper feeder has a lower part and an upper part;
the double-side blanking device comprises the matrix box, a floating trough, a push plate, a flat, a straight-moving element-mounting plate, and a level of a vertical slide rail; the front of the matrix box has two left and right symmetrical oblique dropping grooves; inside the matrix box and perpendicular to the two left and right symmetrical oblique dropping grooves, a plate is set; two floating chutes are set along the vertical slide rail and a horizontal slide rail symmetrically arranged in a substrate in front of the matrix box; an oblique chute below an opening is connected to a floating chute above the opening; a direct-moving element is vertically arranged on the straight-moving element-mounting plate along a central line of the front of the matrix box; the flat is installed at the end of the direct-moving element; and
a copying discharging device comprises a flexible scraper and a mixing mechanism for even spreading; the mixing mechanism includes a support member and a bearing, a drive shaft, and a thick elastic sleeve; the drive shaft is fixed and has two evenly spread parts, and a compact elastic sleeve is installed between the bearing and the two evenly spread parts.

US Pat. No. 10,334,787

DEVICE FOR CONTROLLING THE OUTLET FLAP OF A BALER AND METHOD THEREOF

1. A device for controlling an outlet flap of a baler in at least one manual and one automatic mode, comprising:an outlet flap drive;
a first and a second pressure line via which the outlet flap drive is selectively charged with pressure;
a first pressure measuring means operatively connected to the first pressure line and a second pressure measuring means operatively connected to the second pressure line, the first and second pressure measuring means configured to determine a pressure in each respective pressure line; and
a distributor valve connected to the first and second pressure lines downstream of the first and second pressure measuring means;
wherein, the distributor valve comprises at least a first pass-through position, a second pass-through position, and a shut-off position;
wherein, in the at least one automatic mode, the distributor valve is disposed in a predetermined position dependent on a pressure difference between the pressures in the first and second pressure lines.

US Pat. No. 10,334,786

BALE ACCUMULATOR AND BALE ACCUMULATION METHODS

1. A bale accumulator for grouping rectangular bales for group baling, comprising:a depositor mounted adjacent to a platform for sequentially depositing bale sets onto the platform, each bale set when deposited onto the platform being a pair of rectangular bales positioned upright and side-by-side in a packing orientation with their corresponding long sides being axially juxtaposed;
a packer apparatus mounted adjacent to the platform for packing one bale set at a time from the platform into a bundler trailing the platform each time a bale set is deposited onto the platform from the depositor;
the depositor comprising:
an inlet;
an outlet adjacent to the platform;
a first bale-receiving area and a second bale-receiving area on either side of a divider between the inlet and the outlet, a first entrance to the first bale-receiving area, and a second entrance to the second bale-receiving area;
a gate mounted to the divider for movement between a first position and a second position, the gate including a first diverting arm, a second diverting arm, and a trigger arm;
the first diverting arm extends into the first bale-receiving area, the second diverting arm closes the first entrance to the first bale-receiving area from the inlet leaving the second entrance to the second bale-receiving area open to the inlet for enabling a rectangular bale to drop into the second bale-receiving area through the second entrance from the inlet, and the trigger arm extends into the second bale-receiving area in a path of rectangular bales through the second bale-receiving area, when the gate is in its first position;
the second diverting arm extends into the second bale-receiving area, the first diverting arm closes the second entrance to the second bale-receiving area from inlet leaving the first entrance to the first bale-receiving area open to the inlet for enabling a rectangular bale to drop into the first bale-receiving area through the first entrance from the inlet, and the trigger arm extends into the first bale-receiving area in a path of rectangular bales through the first bale-receiving area, when the gate is in its second position;
each time a rectangular bale passes through the second bale-receiving area when the gate is in the first position it strikes the trigger arm in the second bale-receiving area rotating the gate from the first position to the second position in response moving the trigger arm out of the path of rectangular bales through the second bale-receiving area for enabling the rectangular bale to drop onto the platform through the outlet from the second bale-receiving area; and
each time a rectangular bale passes through the first bale-receiving area when the gate is in the second position it strikes the trigger arm in the first bale-receiving area rotating the gate from the second position to the first position in response moving the trigger arm out of the path of rectangular bales through the first bale-receiving area enabling the rectangular bale to drop onto the platform through the outlet from the first bale-receiving area.

US Pat. No. 10,334,785

HEMP HARVESTER

1. A method for harvesting plants of the hemp genus, hemp stems being cut off above ground and flowers of the hemp plant being stripped from the stems, wherein(a) at least one pair of counter-rotating rollers (7) of a device for harvesting hemp are aligned along the direction of travel, and wherein the rollers are pressed against each other and pull the hemp stems downwards to the ground; and
(b) at least a pair of circumferential chains (9) of the device for harvesting hemp located above the at least one pair of rollers (7) which holds the hemp stem below the flowers and pulls the flowers backwards in a chain gap.

US Pat. No. 10,334,783

STALK ROLL FOR AGRICULTURAL ROW UNIT

CNH Industrial America LL...

1. An agricultural harvester row unit driven in a forward direction to receive crop stalks, said row unit comprising:a pair of rotatable side-by-side stalk rolls in a horizontal plane oriented longitudinally fore and aft relative to the forward direction and having a forward end;
a device for powering said stalk rolls in counter rotating directions;
wherein said stalk rolls each have a forward section with an annular base tapered towards the forward end of said stalk roll and at least one spiral auger flight on said annular base extending radially so that the outer diameter overlaps the outer diameter of an adjacent flight from a rearward end of said annular base significantly towards a forward most portion of said annular base; wherein the outer diameter of the auger flights are constant from the rearward end of said annular base to the forward end of said annular base; and
wherein said at least one auger flight has a leading edge at the forward end thereof, at least a portion of said leading edge adjacent the outer diameter of said at least one spiral auger flight extending perpendicularly relative to the rotational axis of said stalk roll to the outer diameter of said at least one auger flight.

US Pat. No. 10,334,782

GRASS COLLECTION CHUTE FASTENER

1. A grass collection chute fastener, comprising:a lever pivotably connected to a grass collection chute adjacent a first end of the lever; the lever having a main axis between the first end and a second end;
an elastic strap pivotably connected to the lever on a pivot axis offset from the main axis of the lever between the first end and the second end of the lever; and
a hook attached to the strap and insertable into a first hole adjacent a side discharge opening of a multi-blade mower deck to secure the grass collection chute over the side discharge opening by rotating the lever to tension the strap; and
a rod on the grass collection chute engaging the multi-blade mower deck by sliding the grass collection chute forward along a discharge opening guard below the side discharge opening.

US Pat. No. 10,334,779

BALANCED TRIM SHIELD WITH A SINGLE, DUAL DIRECTION LINE CUTTING MEMBER

HUSQVARNA AB, Huskvarna ...

1. A hand-held cutting device comprising:an elongated member graspable along a portion thereof by an operator;
a trimmer head disposed at one end of the elongated member and configured to be rotatable to perform a cutting function using trimmer line held at a portion of the trimmer head;
a power unit operably coupled to the trimmer head to selectively cause rotation of the trimmer head; and
a trim shield disposed to extend away from the elongated member to a position radially outward relative to the trimmer head proximate to at least a portion of a path traced by a distal end of the trimmer line when the trimmer head is rotated,
wherein the trim shield comprises:
a first housing portion disposed on one side of a longitudinal centerline of the device;
a second housing portion disposed on an opposite side of the longitudinal centerline and substantially symmetrical relative to the first housing portion;
a cutter mount disposed at the longitudinal centerline on an interior portion of the trim shield proximate to an intersection of the first housing portion and second housing portion, the cutter mount extending downward from an end of the trimmer shield that is configured to be operably coupled to the elongated member and comprising a first fixing member and a second fixing member; and
a cutting member operably coupled to the cutter mount with substantially equal portions of the cutting member extending to respective opposing sides of the longitudinal centerline, the cutting member comprising a single knife element, the single knife element comprising a first knife edge and a second knife edge,
wherein the cutting member is operably coupled to the cutter mount via the first and second fixing members, the cutting member extending downward from and parallel to the first and second fixing members.

US Pat. No. 10,334,777

ELECTRIC WORK VEHICLE

Kubota Corporation, Osak...

1. An electric work vehicle comprising:a vehicle body;
a carrier provided separately from the vehicle body for mounting/dismounting a battery, the carrier having wheels for movement thereof;
a carrier storage section provided in the vehicle body for attaching the carrier to the vehicle body;
an attachment mechanism for attaching/detaching the carrier to/from the carrier storage section; and
a fixing mechanism for releasably connecting the carrier to the carrier storage section, the fixing mechanism comprising:
a handle portion on the carrier, the handle portion movable between a lowered position and an elevated position; and
an engaging portion on the attachment mechanism,
wherein:
in response to movement of the handle portion to the lowered position when the carrier is attached to the carrier storage section, the handle portion engages the engaging portion to fix the carrier to the carrier storage section, and
in response to movement of the handle portion to the elevated position when the carrier is attached to the carrier storage section, the handle portion disengages the engaging portion to release the carrier to the carrier storage section.

US Pat. No. 10,334,776

METHOD AND SYSTEM HAVING AN INTERMEDIATE HOLDING VESSEL FOR COMBINING CHEMICAL INJECTION SUBSTANCES FOR A SPRAY SYSTEM

AGCO Corporation, Duluth...

1. An agricultural spraying system for use in applying at least one substance to a field, the agricultural spraying system comprising:a main tank containing water;
a plurality of vessels, each containing a substance;
a mixed solution tank containing a mixed solution formed from water from the main tank and a substance from at least one of the plurality of vessels;
a first conduit fluidly connecting the main tank, the plurality of vessels, and the mixed solution tank;
a transfer pump that provides motive force for the water through the first conduit;
an injector associated with each of the vessels, for release of the substance in that vessel into the first conduit;
a mixer positioned along the first conduit between the plurality of vessels and the mixed solution tank configured to mix the water from the main tank and the substance from the at least one of the plurality of vessels prior to reaching the mixed solution tank;
a valve that prevents any of the substances and the mixed solution from entering the main tank;
a boom manifold having an inlet and an outlet with a plurality of applicator spray nozzles positioned between the inlet and outlet that are configured to dispense the mixed solution;
a second conduit fluidly connecting the mixed solution tank and the inlet of the boom manifold;
a spray pump located in the second conduit that provides motive force for the mixed solution through the second conduit, wherein the transfer pump has a greater flow capacity than a flow capacity of the spray pump; and
a third conduit fluidly connecting the outlet of the boom manifold and the mixed solution tank, wherein mixed solution supplied through the second conduit by the spray pump that is not dispensed by the applicator spray nozzles is returned to the mixed solution tank through the third conduit.

US Pat. No. 10,334,774

ADJUSTABLE CLAMP ON HEAD BRACKET

CNH Industrial Canada, Lt...

1. A towable agricultural implement, comprising:a tool bar;
an elongated C-shaped channel member coupled to the tool bar, the C-shaped channel member having a closed side and an open side and defining an inner edge along its open side;
a row unit supported relative to the tool bar via a head bracket; and
a clamping assembly configured to fasten the head bracket to the C-shaped channel member, the clamping assembly comprising a clamping nut and a clamping bolt, the clamping nut including a rigid member defining a threaded aperture configured to receive the clamping bolt, the clamping nut further comprising an elongated lip extending from the rigid member and configured to engage the inner edge of the C-shaped channel member as the clamping bolt is tightened relative to the clamping nut.
US Pat. No. 10,335,366

RISPERIDONE OR PALIPERIDONE IMPLANT FORMULATION

1. An injectable composition consisting ofabout 13% wt of drug which is risperidone and/or paliperidone or any pharmaceutically acceptable salt thereof in any combination; and
a polymeric solution consisting of DMSO and biocompatible poly(lactide-co-glycolide) (PLGA) copolymer having a monomer ratio of lactic acid to glycolic acid of about 50:50 and an inherent viscosity in the range of 0.25-0.30 dl/g measured by gel permeation chromatography in tetrahydrofuran at 30° C. using a flow rate of 1 ml/min; wherein
the mass ratio of polymeric solution to drug is about 6.5:1 to about 7:1; and
the mass ratio of DMSO to drug is about 4:1 to about 5:1.
US Pat. No. 10,336,904

COMPOSITION OF A BLEND OF POLYAMIDE AND POLYESTER RESINS

RHODIA OPERATIONS, Auber...

1. A resin blend composition of a polyamide resin and of a polyester resin, the composition comprising:a) from 1 wt. % to 98 wt. % of a thermoplastic polyamide resin;
b) from 1 wt. % to 98 wt. % of a thermoplastic polyester resin comprising a homopolymer or a copolymer that is obtained by condensation of a dicarboxylic acid or its derivatives that can form an ester, with a diol or its derivatives that can form an ester, or a mixture thereof, wherein the thermoplastic polyester resin comprises at least one C2-C20 aliphatic glycol as the diol monomer;
c) from 0.01 wt. % to 10 wt. % of an epoxy resin having an epoxy equivalent weight (EEW) ranging from 2100 g/eq and 6000 g/eq; and
d) from 1 wt. % to 40 wt. % of a red phosphorus fireproofing agent,wherein the weight percentages are based on the total weight of the composition.
US Pat. No. 10,334,858

COMPOSITIONS AND METHODS FOR THE IMPROVED PRODUCTION AND DELIVERY OF RNA BY EFFICIENT TRANSCRIPTION TERMINATION

1. A transcriptional terminator sequence comprising a nucleic acid sequence selected from the group consisting of SEQ ID NOs: 13, 18, and 21-23.
US Pat. No. 10,335,370

CONTROLLED RELEASE COMPOSITION

1. A controlled release implantable pharmaceutical composition comprising a plurality of microparticles distributed or embedded in a matrix, wherein:the plurality of microparticles comprises poly(L-lactide acid) and a first active agent;
the matrix comprises poly(lactide-co-glycolide acid);
the plurality of microparticles have a diameter ranging from about 120 ?m to about 1000 ?m; and
wherein the controlled release implantable pharmaceutical composition is manufactured by a method comprising the steps of:
preparing the plurality of microparticles;
applying the plurality of microparticles to a matrix-forming composition comprising poly(lactide-co-glycolide acid) to form a mixture;
heating the matrix-forming composition to a temperature Tm wherein 76° C. cooling down to form the controlled release implantable pharmaceutical composition.
US Pat. No. 10,334,859

METHOD AND PESTICIDAL MIXTURES FOR CONTROLLING PENTATOMIDAE PESTS

BASF SE, Ludwigshafen am...

1. A pesticidal mixture comprising as active compounds1) at least one compound (I), which is a component of the ginkgo tree selected from the group consisting of bilobalide, ginkgolide A, ginkgolide B, ginkgolide C, ginkgolide J and ginkgolide M,
and
2) alpha-cypermethrin;
in a synergistically effective amount, wherein the weight ratio of compound I and alpha-cypermethrin is from 5000:1 to 1:5.
US Pat. No. 10,335,373

TAMPER RESISTANT AND DOSE-DUMPING RESISTANT PHARMACEUTICAL DOSAGE FORM

GRUNENTHAL GMBH, Aachen ...

18. A process for the production of a tamper-resistant pharmaceutical dosage form comprising a pharmacologically active ingredient embedded in a prolonged release matrix, which comprises a prolonged release matrix material selected from the group consisting of nonionic acrylic polymers and which provides prolonged release of the pharmacologically active ingredient, wherein the prolonged release matrix material is employed in the form of an aqueous dispersion, and the pharmaceutical dosage form not comprising either ethyl cellulose or an ionic acrylic polymer, andwherein:
(a) the pharmaceutical dosage form is monolithic, has a breaking strength of at least 300 N, and has an extension in any direction of at least 2.0 mm; or
(b) the pharmaceutical dosage form is oligoparticulate or multiparticulate, comprising a plurality of individual particulates, wherein at least a fraction of the individual particulates have a breaking strength of at least 300 N, and wherein individual particulates comprising the pharmacologically active ingredient have an extension in any direction of at least 2.0 mm;
said process comprising extruding a homogeneous mixture comprising the pharmacologically active ingredient and the prolonged release matrix material in the presence of water, and evaporating the water in the course of extrusion.
US Pat. No. 10,334,862

METHODS FOR PRESERVING PROCESSED MEATS

The Hillshire Brands Comp...

1. A method comprising:forming a first portion of meat by adding Propionibacterium to a meat substrate;
artificially inducing glycolysis in the meat substrate;
incubating the first portion of meat to achieve a first propionic concentration in excess of 1% wt.;
after the incubating, mixing the first portion of meat with a second portion of meat to form a third portion of meat, wherein the third portion of meat has a third propionic acid concentration of 0.1%-1% wt., inclusive.
US Pat. No. 10,335,375

ANTI-OVERINGESTION ABUSE DETERRENT COMPOSITIONS

Patheon Softgels, Inc., ...

1. An oral pharmaceutical composition comprising:(a) about 50% to about 70% by mass of glyceryl monolinoleate;
(b) about 2% to 50% by mass ion exchanger;
(c) about 25% to about 40% by mass of a polyethylene oxide having a molecular weight (Mv) of about 1,000,000 to about 7,000,000; and
(d) about 1% to 20% by mass of one or more active pharmaceutical ingredients (API), wherein 15% or about 30% of the API is in a free form and 70% or about 85% of the API is bound to the ion exchanger.
US Pat. No. 10,336,913

CURABLE SILICONE COMPOSITION, CURED PRODUCT THEREOF, AND OPTICAL SEMICONDUCTOR DEVICE

DOW CORNING TORAY CO., LT...

1. A curable silicone composition comprising:(A) a diorganopolysiloxane having at least two alkenyl groups in a molecule and containing siloxane units represented by the formula: R12SiO2/2 wherein each R1 independently represents an aryl group;
(B) at least two types of resinous organopolysiloxanes having different mass average molecular weights based on standard polystyrene conversion gel permeation chromatography, and each comprising siloxane units represented by the formula: SiO4/2, siloxane units represented by the formula: R22R3SiO1/2 wherein each R2 independently represents a monovalent hydrocarbon group lacking aliphatic unsaturated bonds and each R3 independently represents an alkenyl group, and siloxane units represented by the formula: R23SiO1/2 wherein R2 is as defined above, in an amount of 10 to 100 parts by mass per 100 parts by mass of component (A);
(C) an organopolysiloxane having at least two silicon-bonded hydrogen atoms in a molecule, in an amount so that the amount of silicon-bonded hydrogen atoms in component (C) is from 0.1 to 10 mol per 1 mol of total alkenyl groups in components (A) and (B); and
(D) a catalytic amount of hydrosilylation reaction catalyst.
US Pat. No. 10,336,915

ANAEROBICALLY CURABLE COMPOSITIONS

1. An anaerobically curable composition comprising:(a) a (meth)acrylate component;
(b) a cure inducing component; and
(c) at least one stabilizer comprising:at least one C6-C50 aliphatic chain, derived from a fatty acid, said stabilizer further comprising at least 2 nitrogen atoms and at least 4 carboxy groups.
US Pat. No. 10,340,504

METAL AIR BATTERY

Mahle International GmbH,...

1. A metal-air battery comprising:a housing;
at least one hollow-cylindrical cathode arranged in the housing between an air chamber and an electrolyte chamber;
at least one metallic anode arranged in the electrolyte chamber;
an air path leading through the housing from an air inlet of the housing, which is fluidically connected to the air chamber, to an air outlet of the housing, which is fluidically connected to the air chamber;
an air supply device for generating an air flow following the air path impinging on the at least one hollow-cylindrical cathode;
an electrolyte path leading through the housing from an electrolyte inlet of the housing, which is fluidically connected to the electrolyte chamber, to an electrolyte outlet of the housing, which is fluidically connected to the electrolyte chamber; and
an electrolyte supply device for generating an electrolyte flow following the electrolyte path impinging on the at least one metallic anode and the at least one hollow-cylindrical cathode.
US Pat. No. 10,334,870

PROCESSING OF WHOLE FRUITS AND VEGETABLES, PROCESSING OF SIDE-STREAM INGREDIENTS OF FRUITS AND VEGETABLES, AND USE OF THE PROCESSED FRUITS AND VEGETABLES IN BEVERAGE AND FOOD PRODUCTS

TROPICANA PRODUCTS, INC.,...

1. A method of processing pomace comprisingobtaining a pomace press cake by extracting juice from a fruit, vegetable, or combinations thereof;
hydrating the pomace press cake;
acidifying the pomace press cake with an organic acid;
micro-grinding the hydrated, acidified pomace press cake to reduce the particle size of the pomace to less than 250 microns.
US Pat. No. 10,335,384

COMPOSITIONS COMPRISING MAGNOLIA, PHELLODENDRON, THEANINE AND/OR WHEY PROTEIN

NUTRAMAX LABORATORIES, IN...

1. An anxiolytic composition, comprising a combination of L-theanine, a whey protein, an extract of magnolia, and an extract of phellodendron provided in amounts synergistically effective to modulate one or more neurotransmitters.
US Pat. No. 10,336,922

COMPOSITIONS CONTAINING ETHYLENE POLYMERS

Kraton Chemical, LLC, Ja...

1. A composition comprising,(a) a polymer derived from ethylene polymer derived from at least one polar monomer with one or more ester groups, which polymerize with ethylene, and
(b) a rosin ester having a hydroxyl number and an acid number,
wherein the sum of the hydroxyl number and the acid number of the rosin ester is eighteen or less;
wherein the rosin ester has a PAN number of eight or less, an acid number of ten or less, and a weight average molecular weight from 800 g/mol to 2000 g/mol.
US Pat. No. 10,336,670

METHOD FOR PRODUCING HIGH-OCTANE COMPONENTS FROM OLEFINS FROM CATALYTIC CRACKING

1. A method for producing a high-octane component of motor fuels from olefin-containing gas mixtures characterized in that an olefin-containing mixture comprising C2-C4 alkanes and olefins is oxidized with nitrous oxide, followed by an isolation of a product mixture as the high-octane component.
US Pat. No. 10,338,464

PHOTOMASK INCLUDING TRANSFER PATTERNS FOR REDUCING A THERMAL STRESS

SK HYNIX INC., Icheon (K...

1. A photomask comprising:a light transmission substrate;
a plurality of pattern regions disposed over the light transmission substrate, a shape of the plurality of pattern regions being transferred onto a wafer during an exposure process; and
a light blocking region surrounding the plurality of pattern regions,
wherein each of the plurality of pattern regions is a light transmitting region that exposes a portion of the light transmission substrate,
wherein the light blocking region includes first light blocking patterns that respectively surround the plurality of pattern regions to have closed loop shapes and second light blocking patterns that are disposed between adjacent first light blocking patterns, adjacent second light blocking patterns being spaced apart from each other by a first distance in a first direction, and
wherein the first light blocking patterns have a first thickness and the second light blocking patterns have a second thickness which is smaller than the first thickness.
US Pat. No. 10,338,465

PELLICLE FRAME AND PELLICLE

SHIN-ETSU CHEMICAL CO., L...

1. A pellicle frame comprising:a frame base, and
a polymer coating layer coating at least an inner circumferential surface of the frame base, the polymer coating layer comprising an outermost polymer layer on a side farthest away from the frame base and one or more inner polymer layers between the frame base and the outermost polymer layer,
wherein at least one of the one or more inner polymer layers contains particles, and the outmost polymer layer contains no particles or has a particle concentration lower than a highest particle concentration among the one or more inner polymer layers.
US Pat. No. 10,336,673

PROCESS FOR CONVERTING METHANOL TO HYDROCARBONS SUITABLE FOR USE AS GASOLINE OR BLENDSTOCK

1. A process for production of a hydrocarbon product suitable for use as gasoline or as a blendstock, said process comprising:converting a feed stream comprising alcohols, ethers or mixtures thereof over a metal-containing zeolite based catalyst, active in dehydrogenation of hydrocarbons, in a conversion step thereby obtaining a conversion effluent,
separating said effluent to obtain an aqueous process condensate stream, a liquid hydrocarbon stream and a gaseous stream,
removing H2 from at least part of the effluent thereby obtaining at least one at least partially H2 depleted recycle stream, wherein removing H2 is via a selective membrane, a selective oxidation step and/or a step wherein a hydrogen scavenger is converted into methanol or water in the presence of H2 and a hydrogenation catalyst, and
recycling the at least one at least partially H2 depleted recycle stream to the conversion step.
US Pat. No. 10,336,679

POLYMORPHIC FORMS OF SODIUM BENZOATE AND USES THEREOF

SyneuRx International (Ta...

1. A polymorphic form of sodium benzoate, which has an X-ray diffraction pattern comprising characteristic peaks at a reflection angle 2? of approximately 5.9, 30.2, and 31.2 degrees, wherein the X-ray diffraction pattern further comprises characteristic peaks at a reflection angle 2? of approximately 4.3, 7.1, 8.6, 10.1, 10.7, 12.9, 13.8, 14.4, 17.2, 17.7, 18.5, 21.5, 22.0, 22.6, 23.7, 25.1, 25.9, 26.2, 26.9, 27.9, 28.2, 28.8, 29.1, 29.7, 33.2, 34.9, 35.8, 36.1, and 39.3 degrees, and wherein the polymorphic form of sodium benzoate has a water solubility of 666 mg/ml at ambient temperature.
US Pat. No. 10,338,474

UNDERLYING ABSORBING OR CONDUCTING LAYER FOR EBEAM DIRECT WRITE (EBDW) LITHOGRAPHY

Intel Corporation, Santa...

1. A method of patterning a resist layer using an e-beam tool, the method comprising:providing a wafer having a resist layer directly on an underlying conducting layer; and
performing ebeam direct write lithography to pattern the resist layer with incident electrons, wherein the conducting layer reflects or conducts away a substantial portion of the incident electrons to diminish backscatter.
US Pat. No. 10,336,681

PROCESS FOR THE SYNTHESIS OF DIALKYL CARBONATES

1. A process for the synthesis of dialkyl carbonates, using a catalyst of AB oxides supported on a support selected from carbon, neutral alumina or silica, the process comprising the steps of:a. charging alkyl carbamate and aliphatic alcohol (1:5) in a high pressure reactor, adding the catalyst and heating the reactor to 100-300° C. with stirring; and
b. removing ammonia formed over the period of reaction and cooling the reaction to room temperature to obtain the desired alkyl carbonate;
wherein the dialkyl carbonates are dimethyl carbonate (DMC), diethyl carbonate (DEC), dipropyl carbonate (DPC) or dibutyl carbonate (DBC); and
wherein A and B are selected from rare earth, transition metals and alkaline earth metals and the AB oxide has an A:B ratio ranging from 0.5:10 to 10:0.5.
US Pat. No. 10,336,938

LIQUID CRYSTAL COMPOSITION

Sumitomo Chemical Company...

1. A liquid crystal composition comprising a polymerizable liquid crystal compound (A) having 5 or more ring structures in its main chain, a polymer (B) of the polymerizable liquid crystal compound (A) having 5 or more ring structures in its main chain, and an organic solvent capable of dissolving the polymerizable liquid crystal compound (A) and the polymer (B),wherein the polymer (B) has an area percentage value determined by gel permeation chromatography (GPC) of 0.01% or more and 40% or less, and
wherein the polymerizable liquid crystal compound (A) is a polymerizable liquid crystal compound represented by the following formula (A):
P1—F1?B1-A1?mE1-G1-D1-Ar-D2-G2-E2?A2-B2?nF2—P2  (A)
in formula (A), m and n each independently represent an integer of 0 to 3;
B1, B2, D1, D2, E1, and E2 each independently represent —CR1R2—, —CH2—CH2—, —O—, —S—, —CO—O—, —O—CO—, —O—CO—O—, —C(?S)—O—, —O—C(?S)—, —O—C(?S)—O—, —CO—NR1—, —NR2—CO—, —O—CH2—, —CH2—O—, —S—CH2—, —CH2—S—, or a single bond, and R1 and R2 each independently represent a hydrogen atom, a fluorine atom, or an alkyl group having 1 to 4 carbon atoms;
A1, A2, G1, and G2 each independently represent a divalent alicyclic hydrocarbon group having 3 to 16 carbon atoms or a divalent aromatic hydrocarbon group having 6 to 20 carbon atoms, the hydrogen atom contained in the alicyclic hydrocarbon group and the aromatic hydrocarbon group is optionally substituted with a halogen atom, —R3, —OR3, a cyano group, or a nitro group, —CH2— contained in the alicyclic hydrocarbon group is optionally substituted with —O—, —S—, —NH—, or —NR4—, and —CH(—)— contained in the alicyclic hydrocarbon group is optionally substituted with —N(—)—, R3 and R4 each independently represent an alkyl group having 1 to 4 carbon atoms, and the hydrogen atom contained in the alkyl group is optionally substituted with a fluorine atom;
F1 and F2 each independently represent an alkanediyl group having 1 to 12 carbon atoms, the hydrogen atom contained in the alkanediyl group is optionally substituted with —OR3 or a halogen atom, and —CH2— contained in the alkanediyl group is optionally substituted with —O— or —CO—;
P1 and P2 each independently represent a hydrogen atom or a polymerizable group (provided that at least one of P1 and P2 represents a polymerizable group), and
Ar is a divalent aromatic group which is optionally substituted, and at least one of a nitrogen atom, an oxygen atom, or a sulfur atom is contained in the aromatic group.
US Pat. No. 10,335,402

SULFONYL PIPERIDINE DERIVATIVES AND THEIR USE FOR TREATING PROKINETICIN MEDIATED GASTROINTESTINAL DISORDERS

Takeda Pharmaceutical Com...

1. A method of treating irritable bowel syndrome or inflammatory bowel disease comprising administering to a patient in need thereof a compound selected from:Methyl 2-(4-Chlorophenyl)-2-(1-((3,5-dimethyl-1H-pyrazol-4-yl)sulfonyl)piperidin-4-ylidene)acetate,
2-(4-Chlorophenyl)-2-(1-((3,5-dimethyl-1H-pyrazol-4-yl)sulfonyl)piperidin-4-ylidene)acetonitrile,
2-(2,6-Difluorophenyl)-2-(1-((3,5-dimethyl-1H-pyrazol-4-yl)sulfonyl)piperidin-4-ylidene)acetonitrile,
2-(4-Chloro-2-fluorophenyl)-2-(1-((3,5-dimethyl-1H-pyrazol-4-yl)sulfonyl)piperidin-4-ylidene)acetonitrile,
2-(4-Chlorophenyl)-2-(1-((3,5-diethyl-1H-pyrazol-4-yl)sulfonyl)piperidin-4-ylidene)acetonitrile,
2-(4-Chlorophenyl)-2-(1-((1,5-dimethyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)sulfonyl)piperidin-4-ylidene)acetonitrile,
2-(2,6-Difluorophenyl)-2-(1-((1,3,5-trimethyl-1H-pyrazol-4-yl)sulfonyl)piperidin-4-ylidene)acetonitrile,
2-(1-((3,5-Dimethyl-1H-pyrazol-4-yl)sulfonyl)piperidin-4-ylidene)-2-(4-(trifluoromethoxy)phenyl)acetonitrile,
2-(4-Chlorophenyl)-2-(1-((3,5-dimethyl-1H-pyrazol-4-yl)sulfonyl)-3-methylpiperidin-4-ylidene)acetonitrile,
4-(4-Chloro-2-fluorobenzylidene)-1-((3,5-dimethyl-1H-pyrazol-4-yl)sulfonyl)piperidine,
4-(4-Chloro-2-fluorobenzylidene)-1-((1,3,5-trimethyl-1H-pyrazol-4-yl)sulfonyl)piperidine,
4-(1-(4-Chlorophenyl)ethylidene)-1-((3,5-dimethyl-1H-pyrazol-4-yl)sulfonyl)piperidine,
4-(4-Chlorobenzylidene)-1-((3,5-dimethyl-1H-pyrazol-4-yl)sulfonyl)piperidine,
2-(4-Chlorophenyl)-2-(1-((1,3,5-trimethyl-1H-pyrazol-4-yl)sulfonyl)piperidin-4-ylidene)acetonitrile,
4-((4-Chlorophenyl)fluoromethylene)-1-((3,5-dimethyl-1H-pyrazol-4-yl)sulfonyl)piperidine,
4-((3-Chloro-4-fluorophenyl)fluoromethylene)-1-((3,5-dimethyl-1H-pyrazol-4-yl)sulfonyl)piperidine,
4-((2,4-Dichlorophenyl)fluoromethylene)-1-((3,5-dimethyl-1H-pyrazol-4-yl)sulfonyl)piperidine,
4-((3,4-Dichlorophenyl)fluoromethylene)-1-((3,5-dimethyl-1H-pyrazol-4-yl)sulfonyl)piperidine,
4-((4-Chloro-3-fluorophenyl)fluoromethylene)-1-((3,5-dimethyl-1H-pyrazol-4-yl)sulfonyl)piperidine,
4-((4-Chloro-2-fluorophenyl)fluoromethylene)-1-((3,5-dimethyl-1H-pyrazol-4-yl)sulfonyl)piperidine,
4-((2,4-Difluorophenyl)fluoromethylene)-1-((3,5-dimethyl-1H-pyrazol-4-yl)sulfonyl)piperidine,
3-((1-((3,5-Dimethyl-1H-pyrazol-4-yl)sulfonyl)piperidin-4-ylidene)fluoromethyl)quinoline, and pharmaceutically acceptable salts of any one thereof.
US Pat. No. 10,336,941

IMPACT-MODIFIED HYDROXYAPATITE AS FLAME RETARDANT POLYMER FILLERS

International Business Ma...

1. An impact resistant hydroxyapatite-based compound comprising hydroxyapatite functionalized with optionally substituted poly(butadiene-co-styrene).
US Pat. No. 10,335,405

NON-BURST RELEASING PHARMACEUTICAL COMPOSITION

Patheon Softgels, Inc., ...

1. An abuse deterrent oral pharmaceutical composition comprising a tamper resistant controlled release matrix comprising:(a) about 50% to about 65% by weight oleic acid or glyceryl monolinoleate;
(b) about 25% to about 35% by weight polyethylene oxide;
(c) 1% to about 5% by weight ethylcellulose having a viscosity of about 20 cP;
(d) 1% to about 5% by weight sodium lauryl sulfate; and
(e) 1.5% to about 10% by weight hydrocodone;
wherein the matrix is resistant to tampering and prevents the burst release of the one or more active pharmaceutical ingredients and is encapsulated in a capsule shell.
US Pat. No. 10,335,407

USE OF FLIBANSERIN IN THE TREATMENT OF OBESITY

Sprout Pharmaceuticals, I...

1. A pharmaceutical composition comprising a) an active substance being not flibanserin, selected from the group comprising pioglitazone or a pharmaceutical acceptable salt thereof, troglitazone, rosiglitazone or a pharmaceutical acceptable salt thereof, JTT-501, GI-262570, MCC-555, YM-440, DRF-2593, BM-13-1258, KRP-297, R-119702, GW-1929, tolbutamide, chloropropamide, tolazamide, acetohexamide, glyclopyramide, an ammonium salt of glyclopyramide, glibenclamide, gliclazide, glimepiride, repaglinide, nateglinide, mitiglinide, JTT-608, metformin, bovine insulin, porcine insulin, semisynthetic human insulin, genetically-engineered human insulin, acarbose, voglibose, miglitol, emiglitate, AJ-9677, BMS-196085, SB-226552, AZ40140, tolrestat, epalrestat, imirestat, zenarestat, SNK-860, zopolrestat, ARI-50i, AS-3201, NGF, LY-333531, LAF237, MK431, 815541, 823093, 825964, liraglutide, exenatide, AVE-2268, T-1095, mazindol, baiamine, NGD-95-1, lipstatin, rimonabant, phenylpropanolamine, ephedrine, pseudroephedrine, dexfenfluramine, fenfluramine, BVT.933, APD356, bromocriptine, pramipexol, dehydroepiandrosterone, exendin, AC 2993, CJC-1131, ZP10, GRT0203Y, captopril, enalapril, alacepril, delapril, lisinopril, imidapril, benazepril, cilazapril, temocapril, trandolapril, manidipine, nifedipine, amlodipine, efonidipine, nicardipine, levcromakalim, L-27152, AL0671, NIP-121, telmisartan, losartan, candesartan cilexetil, valsartan, irbesartan, CS-866, E4177, pravastatin or a pharmaceutical acceptable salt thereof, simvastatin or a pharmaceutical acceptable salt thereof, lovastatin or a pharmaceutical acceptable salt thereof, atorvastatin or a pharmaceutical acceptable salt thereof, fluvastatin or a pharmaceutical acceptable salt thereof, lipantil or a pharmaceutical acceptable salt thereof, cerivastatin or a pharmaceutical acceptable salt thereof, itavastatin or a pharmaceutical acceptable salt thereof, ZD-4522 or a pharmaceutical acceptable salt thereof, bezafibrate, clinofibrate, clofibrate, simfibrate, or mixtures thereof and b) flibanserin, optionally in form of the free base, and/or a pharmacologically pharmaceutically acceptable acid addition salt thereof.
US Pat. No. 10,335,411

ADMINISTRATION OF UBIQUITIN-ACTIVATING ENZYME INHIBITOR AND RADIATION

Millennium Pharmaceutical...

1. A method of treating cancer, comprising administering to a patient in need of such treatment a combination of ((1R,2R,3S,4R)-2,3-dihydroxy-4-(2-(3-(trifluoromethylthio)phenyl)pyrazolo[1,5-a]pyrimidin-7-ylamino)cyclopentyl)methyl sulfamate (Compound 1) or a pharmaceutically acceptable salt thereof and radiation, wherein the cancer is selected from the group consisting of breast cancer, colorectal cancer, ovarian cancer, lung cancer, prostate cancer, head and neck cancer, gastric cancer, esophageal cancer, gastro-esophageal junction cancer, multiple myeloma, and non-Hodgkin's lymphoma; andwherein the radiation is particle radiation or administered by external beam radiation.
US Pat. No. 10,340,026

QTL RESPONSIBLE FOR TOMATO FRUIT FIRMNESS

Syngenta Participations A...

1. A method for selecting a cultivated Solanum lycopersicum tomato plant with fruit having increased firmness as compared with fruit from a control Solanum lycopersicum tomato plant, the method comprising:a. detecting in the cultivated Solanum lycopersicum tomato plant the presence of QTL1, wherein detecting the presence of QTL1 comprises:
i. providing a sample of genomic DNA from the cultivated Solanum lycopersicum tomato plant; and
ii. detecting in the sample of genomic DNA at least one DNA marker linked to QTL1 selected from DNA markers TG599, NT3374, TG246, and NT5880, wherein:
DNA marker TG599 can be detected in a nucleic acid amplification reaction by a forward primer of SEQ ID NO: 19 and a reverse primer of SEQ ID NO: 20,
DNA marker NT3374 can be detected in a nucleic acid amplification reaction by a forward primer of SEQ ID NO: 7 and a reverse primer of SEQ ID NO: 8,
DNA marker TG246 can be detected in a nucleic acid amplification reaction by a forward primer of SEQ ID NO: 17 and a reverse primer of SEQ ID NO: 18, and
DNA marker NT5880 can be detected in a nucleic acid amplification reaction by a forward primer of SEQ ID NO: 9 and a reverse primer of SEQ ID NO: 10; and
b. selecting a cultivated Solanum lycopersicum tomato plant comprising QTL1, thereby selecting a cultivated Solanum lycopersicum tomato plant with fruit having increased firmness as compared with a control Solanum lycopersicum tomato plant that does not comprise QTL1.
US Pat. No. 10,340,027

IDENTIFICATION OF MULTI-MODAL ASSOCIATIONS BETWEEN BIOMEDICAL MARKERS

Koninklijke Philips N.V.,...

1. A method for identifying and treating a patient responsive to cancer therapy comprising:receiving a primary dataset comprising data on at least one stratifying biomedical marker and/or a network node, the primary dataset being associated with a healthy subject;
receiving a secondary dataset comprising data on at least one stratifying biomedical marker and/or a network node, the secondary dataset being associated with a subject affected by a medical condition which may be treatable by cancer therapy;
comparing said primary dataset with said secondary dataset and/or with external datasets to generate a significance value for said stratifying biomedical markers;
identifying a network among the stratifying biomedical markers with other members of the network based on the significance value supplemented with a correction procedure;
ranking members of the identified network according to a ranking score based upon a reference network metric to identify network nodes and/or high ranking network members associated with the medical condition of the secondary subject;
determining potential responsiveness of the patient to cancer therapy based on the association between the identified network nodes and/or high ranking network members and the stratifying biomedical markers;
selecting and treating patients with a cancer therapy based on the identified high ranking network members and the stratifying biomedical markers.
US Pat. No. 10,340,028

METHOD FOR DESIGNING RNA BINDING PROTEIN UTILIZING PPR MOTIF, AND USE THEREOF

1. A method for predicting the function for the fertility restoration of a PPR protein obtained from a test plant, based on the predetermined PPR protein relating to fertility, wherein the PPR protein is a protein containing one or more of PPR motifs each consisting of a polypeptide of 30- to 38-amino acid length represented by the formula 1:(HelixA)-X-(HelixB)-L  (Formula 1)
wherein, in formula 1, Helix A is a moiety of 12-amino acid length capable of forming an ?-helix structure, and is represented by the formula 2:
A1-A2-A3-A4-A5-A6-A7-A8-A9-A10-A11-A12  (Formula 2)
wherein, in the formula 2, A1 to A12 independently represent an amino acid;
wherein, in the formula 1, X is a moiety of 1- to 9-amino acid length and is optional;
wherein, in the formula 1, Helix B is a moiety of 11- to 13-amino acid length capable of forming an ?-helix structure; and
wherein, in the formula 1, L is a moiety of 2- to 7-amino acid length represented by the formula 3;
Lvii-Lvi-Lv-Liv-Liii-Lii-Li  (Formula 3)
wherein, in the formula 3, Li to Lvii independently represent an amino acid, and Liii to Lvii are optional,
said method comprising
extracting an amino acid sequence of each of three amino acids A1, A4 and Lii or two amino acids A4 and Lii from an amino acid sequence of a PPR motif in the test plant,
determining whether the three amino acids A1, A4 and Lii, or two amino acids A4 and Lii in the test plant are the same as the corresponding amino acids in the predetermined PPR protein relating to fertility.
US Pat. No. 10,335,421

TOPICAL WOUND CARE FORMULATION

1. A topical formulation, comprising:(a) silver sulfadiazine;
(b) urogastrone;
(c) camphor;
(d) menthol; and
(e) eucalyptus.
US Pat. No. 10,339,267

SYSTEMS AND METHODS FOR DETERMINING THE PROBABILITY OF A PREGNANCY AT A SELECTED POINT IN TIME

CELMATIX, INC., New York...

1. A system for determining a probability of achieving a pregnancy at a selected point in time, the system comprising:a central processing unit (CPU); and
storage coupled to said CPU for storing instructions that when executed by the CPU cause the CPU to:
train a prognosis predictor, using training data from a population that includes women who ceased pregnancy attempts after one or more reproductive cycles without conception and women who continued pregnancy attempts until live birth, to determine a correlation between fertility-associated characteristics and known pregnancy outcomes, the fertility-associated characteristics comprising phenotypic traits, fertility-associated interventions, and pregnancy outcomes;
accept as input, data representative of a plurality of fertility-associated phenotypic traits of a female subject;
analyze the input data using the prognosis predictor;
provide, based on the analysis, a probability of achieving a pregnancy at a selected point in time; and
treating the female subject with a fertility treatment based on the probability of achieving a pregnancy.
US Pat. No. 10,336,963

AROMATIC TETRAHEDRAL BORATE COMPOUNDS FOR LUBRICATING COMPOSITIONS

THE LUBRIZOL CORPORATION,...

1. A lubricating composition comprising:an oil of lubricating viscosity; and
an ionic tetrahedral borate compound comprising an ammonium cation and a tetrahedral borate anion which comprises a boron atom, the boron atom having at least one aromatic bidentate di-oxo ligand, and
wherein the ammonium cation has a molecular weight of at least 260 g/mol and is derived from a dispersant selected from polyisobutenyl succinimide, polyamine dispersants, and solubilized fatty acid amines.
US Pat. No. 10,336,964

GREASE COMPOSITION AND BEARING

KYODO YUSHI CO., LTD., F...

1. A grease composition for bearing comprising a base oil, a urea-containing thickener and a seizing life extending additive, whereinthe base oil is alkyldiphenyl ether,
the urea-containing thickener is represented by the following formula (1):
R1NH—CO—NH—R3—NH—CO—NHR2  (1)
wherein R1 and R2, which may be the same or different, represent an aryl group having 6 or 7 carbon atoms, and R3 is
—C6H4—CH2—C6H4—, —C6H4—, or C6H3(CH3)—,
wherein the seizing life extending additive extends seizing life of the grease composition and comprises an overbased Ca or Na sulfonate,
wherein an amount of the base oil is 79.6 mass % or more with respect to the total amount of the grease composition,
wherein an amount of the urea-containing thickener is 19 to 20 mass % with respect to the total amount of the grease composition and
wherein an amount of the overbased Ca or Na sulfonate is 0.1 to 0.4 mass % with respect to the total amount of the grease composition.
US Pat. No. 10,340,553

ELECTROLYTES FOR WIDE OPERATING TEMPERATURE LITHIUM-ION CELLS

California Institute of T...

1. An electrolyte for use in an electrochemical cell, the electrolyte comprising a mixture of:15-30% by volume a cyclic carbonate, wherein the cyclic carbonate is a non-fluorinated cyclic carbonate;
15-30% by volume a non-cyclic carbonate;
40-70% by volume a linear ester;
a lithium salt in a concentration from 0.5 M to 1.5 M; and
lithium oxalate;wherein the cyclic carbonate, the non-cyclic carbonate and the linear ester are present in a combined total volume of 100 vol % and the lithium oxalate is present at a concentration selected over the range of 0.05 M to 0.25 M.
US Pat. No. 10,335,429

ASSOCIATION OF BETA-GLUCANS AND ARABINOXYLANS

Generale Biscuit, Clamar...

1. A biscuit comprising a first cereal comprising beta-glucans and a second cereal comprising arabinoxylans, wherein the second cereal is different from the first cereal, wherein the biscuit comprises from 4 to 12 wt % of the arabinoxylans and from 9 to 18 wt % of the beta-glucans, and wherein the ratio of the beta-glucans in the first cereal to the arabinoxylans in the second cereal is from 11:9 to 7:3.
US Pat. No. 10,336,967

LAUNDRY DETERGENT COMPOSITION COMPRISING BRANCHED ALKYL ALKOXYLATED SULPHATE

1. A solid free-flowing particulate laundry detergent composition comprising:(a) C11-C13 alkyl benzene sulphonate detersive surfactant;
(b) C11-C15 alkyl ethoxylated sulphate having an average degree of ethoxylation of from about 0.5 to about 3.0, and comprising a C1-C5 alkyl branch in the position C2, and having an average degree of branching of from about 0.01 to 0.12;
(c) wherein the composition is substantially free of zeolite builder; and
(d) wherein the composition is substantially free of phosphate builder.
US Pat. No. 10,336,714

PROCESS FOR PREPARING A NOVEL CRYSTALLINE FORM OF METSULFURON-METHYL AND USE OF THE SAME

Rotam Agrochem Internatio...

1. A crystalline modification I of metsulfuron-methyl (methyl 2-[[[[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)amino]carbonyl]amino]sulfonyl]benzoate) obtained by (i) dissolving metsulfuron-methyl in an amorphous state into at least one of methanol or ethanol to create a slurry, (ii) heating the slurry to prepare a homogeneous solution, (iii) filtering the homogeneous solution to remove any insoluble particles, (iv) cooling the solution to form crystals, (v) mixing the cooled crystalline solution, (vi) filtering the crystalline solution to obtain filtered crystals, (vii) washing the filtered crystals with said at least one of methanol or ethanol, and (viii) drying the washed crystals under vacuum, wherein the obtained crystalline modification I of metsulfuron-methyl exhibiting each of the following reflexes as 2? values in X-ray powder diffractogram recorded using Cu-K? radiation at 25° C.:2?=6.28±0.2  (1)
2?=12.61±0.2  (2)
2?=13.50±0.2  (3)
2?=16.59±0.2  (4)
2?=17.66±0.2  (5)
2?=19.70±0.2  (6)
2?=21.63±0.2  (7)
2?=21.84±0.2  (8)
2?=23.22±0.2  (9)
2?=24.21±0.2  (10)
2?=27.25±0.2  (11)
2?=27.98±0.2  (12), and
2?=29.25±0.2  (13); and
wherein the crystalline modification I of metsulfuron-methyl exhibits a Differential Scanning Calorimeter (DSC) thermogram having an endothermic melting peak with onset at 170.5° C. and peak maximum at 173.6° C.
US Pat. No. 10,336,970

LIQUID DETERGENT COMPOSITION COMPRISING AN ENCAPSULATED ENZYME

1. A water-soluble unit dose article comprising a water-soluble film and a liquid detergent composition comprising between 25% and 55% by weight of the liquid detergent composition of a non-soap surfactant, wherein the non-soap surfactant comprises an anionic surfactant and a non-ionic surfactant and wherein the weight ratio of anionic surfactant to non-ionic surfactant is between 23:1 to 2.5:1; andwherein the liquid detergent composition comprises an encapsulated enzyme.
US Pat. No. 10,340,045

METHOD AND SYSTEM FOR MICROBIOME-DERIVED DIAGNOSTICS AND THERAPEUTICS FOR AUTOIMMUNE SYSTEM CONDITIONS

uBiome, Inc., San Franci...

1. A method for at least one of characterizing, diagnosing, and treating an autoimmune condition of a subject, the method comprising:providing sampling kits to a population of subjects at remote locations, each sampling kit including a sample container having a pre-process reagent component;
receiving an aggregate set of samples from the sampling kits of the population of subjects;
with a next generation sequencing platform of a sample processing system, generating sequence datasets upon sequencing nucleic acid content of microorganism portions of the aggregate set of samples;
generating a microbiome feature dataset for the population of subjects based upon the sequence datasets for the population of subjects;
generating a characterization model of the autoimmune condition from features extracted from the microbiome feature dataset and a supplementary dataset informative of characteristics associated with the autoimmune condition;
characterizing the subject with the autoimmune condition upon processing a sample from the subject according to the characterization model; and
at an output device associated with the subject, providing a therapy to the subject with the autoimmune condition.
US Pat. No. 10,336,971

ODOR REDUCTION

1. A method for reducing odor generated by activity of a lipase, wherein said method comprises a step of adding to said lipase a peptide capable of binding to said lipase,wherein said lipase has the amino acid sequence comprising SEQ ID NO: 1, or a sequence identity of at least 90% with SEQ ID NO: 1; and
wherein said peptide has the amino acid sequence comprising SEQ ID NO: 2, or a sequence identity of at least 90% with at least one major lipase contact zone of SEQ ID NO: 2.
US Pat. No. 10,335,434

ISCHEMIC TISSUE CELL THERAPY

University of South Flori...

1. A method of treating nerve damage in a patient in need thereof consisting of:obtaining a therapeutic consisting of an isolated population of CD14+ monocyte lineage cells from human umbilical cord blood cells (hUCBCs); and
administering via transplantation the therapeutic consisting of the isolated population of CD14+ monocyte lineage cells to the patient in need thereof.
US Pat. No. 10,336,716

THERMODYNAMICALLY STABLE CRYSTAL MODIFICATION OF 2-METHYL-N-(5-METHYL-1, 3, 4-OXADIAZOL-2-YL)-3-(METHYLSULFONYL)-4-(TRIFLUOROMETHYL)BENZAMIDE

BAYER CROPSCIENCE AKTIENG...


US Pat. No. 10,336,972

METHOD OF PRETREATING FABRICS

1. A method of laundering a fabric comprising the steps of:(a) applying a laundry pretreat composition to a stain on a fabric in a pretreat step; and
(b) washing the fabric from step (a) in an automatic or semiautomatic washing machine or in a hand wash operation;
wherein said laundry pretreatment composition comprises:
i. between about 0.0001% and about 8% by weight of the composition of a non-surfactant benefit agent,
the non-surfactant benefit agent comprising a hueing dye selected from a chemical class selected from the group consisting of acridine, anthraquinone, benzodifurane, benzodifuranone, carotenoid, diazahemicyanine, diphenylmethane, formazan, hemicyanine, indigoids, methane, naphthoquinone, nitro, nitroso, oxazine, phthalocyanine, triarylmethane, triphenylmethane, and mixtures thereof;
ii. between about 40% and about 80% by weight of the composition of an alkoxylated alkyl surfactant system, wherein the alkoxylated alkyl surfactant comprise a first alkoxylated alkyl surfactant and a second alkoxylated alkyl surfactant, wherein:
I. the first surfactant has the general structure R-A, where R is a linear or branched alkyl chain having a chain length of between about 6 and about 18 carbon atoms, A is at least one alkoxy group having an average degree of alkoxylation of between about 2 and about 12 and wherein the alkoxy groups consist of identical repeat alkoxy groups or identical repeat alkoxy group blocks wherein a block comprises at least two alkoxy groups;
II. the second surfactant has the general structure R?-E-C, wherein R? is a linear or branched alkyl chain having a chain length of between about 6 and about 18 carbon atoms, E is an ethoxy chain consisting of between about 2 and about 12 ethoxy groups and C is an end cap, wherein the end cap is selected from:
a. an alkyl chain consisting of between 1 and 8 alkoxy groups selected from propoxy groups, butoxy groups and a mixture thereof;
b. an —OH group;
c. a linear or branched alkyl chain of the general formula R? wherein R? comprises between about 1 and about 8 carbon atoms;
d. or a mixture thereof; and
iii. between 0% and about 40% by weight of the composition of a solvent, wherein the solvent is selected from polar protic solvents wherein the non-surfactant benefit agent has a hydrophilic index, and the first surfactant has a hydrophilic index and wherein the hydrophilic index of the non-surfactant benefit agent is within about 0.7 and about 1.5 times that of the hydrophilic index of the first surfactant.
US Pat. No. 10,335,435

METHOD FOR ENDOSCOPICALLY DELIVERING STEM CELLS TO THE BRAIN USING AN INTRANASAL, INJECTABLE APPROACH

1. A method for delivery of therapeutic stem cells to a central nervous system of a mammal having a blood-brain barrier and a nose with a nasal cavity, comprising:inserting an endoscopic device into said nasal cavity;
injecting said therapeutic stem cells intranasally into nasal structure within the nasal cavity of the nose using a needle and syringe under endoscopic guidance; and
enabling said therapeutic stem cells to access the central nervous system by bypassing the blood-brain barrier,
wherein injecting said therapeutic stem cells comprises:
injection of said stem cells as a stem cell solution solely within mucosal and sub-mucosal tissue covering said nasal structure,
causing said mucosal and sub-mucosal tissue to balloon out upon injection of said stem cell solution;
visually observing the ballooning out of said mucosal and sub-mucosal tissue with said endoscopic device; and
determining correct depth of placement of the stem cell solution solely within said mucosal and sub-mucosal tissue upon direct visual observation of the ballooning out of said tissue.
US Pat. No. 10,336,973

ARTICLES COMPRISING WATER-SOLUBLE POLYVINYL ALCOHOL FILM WITH PLASTICIZER BLEND AND RELATED METHODS

1. An article comprising:a. a water-soluble film, wherein the water-soluble film comprises:
a polyvinyl alcohol (PVOH) polymer, wherein the PVOH polymer comprises a polymer blend comprising a first PVOH copolymer comprising a first anionic monomer unit selected from the group consisting of acrylamido methylpropanesulfonic acids, alkali metal salts thereof, and combinations thereof, and a second PVOH copolymer comprising a second anionic monomer unit selected from the group consisting of monomethyl maleate, alkali metal salts thereof, and combinations thereof, wherein the first PVOH copolymer is present in an amount of about 20 wt. % of total PVOH polymers in the film; and the second PVOH copolymer is present in an amount of about 80 wt. % of total PVOH polymers in the film;
dipropylene glycol as a first plasticizer;
sorbitol as the second placticizer; and
glycerin as the third plasticizer; wherein the first, second, and third plasticizers are present in the water-soluble film in a combined amount in a range of about 5 parts to about 50 parts total plasticizer per 100 parts total resin (phr) in the water-soluble film; wherein the first plasticizer is present in the water-soluble film in an amount in a range of about 13 wt. % to about 58 wt. % relative to the combined amount of the first, second, and third plasticizers in the water-soluble film; wherein the second plasticizer is present in the water-soluble film in an amount in a range of about 13 wt. % to about 58 wt. % relative to the combined amount of the first, second, and third plasticizers in the water-soluble film; wherein the third plasticizer is present in the water-soluble film in an amount in a range of about 28 wt. % to about 73 wt. % relative to the combined amount of the first, second, and third plasticizers in the water-soluble film; and
b. a household care composition.
US Pat. No. 10,335,436

MEDICAL TREATMENT COMPOSITION COMPRISING MAMMALIAN DENTAL PULP STEM CELLS

1. A composition comprising:a biological material obtained from a cryopreserved mammalian dental pulp, the cryopreserved mammalian dental pulp including a cryoprotectant being dimethyl sulfoxide, wherein the biological material is in suspension form and includes:
(i) a plurality of non-cultured stem cells, including hematopoietic stem cells, and
(ii) extracellular matrix proteins;
wherein the composition is in a form that is safe for injection into a subject to treat a disease or injury.
US Pat. No. 10,335,439

METHOD FOR PRODUCING HUMAN CORNEAL EPITHELIUM SHEET

JCR Pharmaceuticals Co., ...

1. A method for producing cells derived from human corneal epithelial cells, which comprises a process wherein, in a culture vessel separated into first and second chambers by a membrane having micropores that disallow cells to pass through, feeder cells are added to the first chamber and human corneal epithelial cells are added to the second chamber, said human corneal epithelial cells are cultured on the membrane having micropores by using a first medium containing a Rho-associated protein kinase (ROCK) inhibitor and a phosphodiesterase inhibitor, but not containing a mitogen-activated protein (MAP) kinase inhibitor and a TGF-? receptor inhibitor, and then said human corneal epithelial cells are cultured by using a second medium containing a phosphodiesterase inhibitor, a mitogen-activated protein (MAP) kinase inhibitor, and a TGF-? receptor inhibitor, but not containing a Rho-associated protein kinase (ROCK) inhibitor.
US Pat. No. 10,336,983

METHOD FOR INCREASING THE SPECIFIC PRODUCTION RATE OF EUKARYOTIC CELLS

Hoffmann-La Roche Inc., ...

1. A method for increasing specific productivity (qP) of a recombinant Chinese Hamster Ovary (CHO) cell that produces an exogenous polypeptide, the method comprising culturing the CHO cell in a culture medium comprising meta-tyrosine at a concentration of from 0.2 mM to 0.7 mM, whereby the specific productivity (qP) is increased by at least 5% compared to an identical culturing process without supplementation of meta-tyrosine in the culture medium.
US Pat. No. 10,335,446

METHODS OF TREATING DISEASES USING GRAPE PROTEINS

1. A method of treating leukemia in a human in need thereof consisting essentially of administering a therapeutically effective amount of a composition of grape seed and grape stem to said human in need thereof to effectively treat the leukemia in said human in need thereof.
US Pat. No. 10,335,448

COMPOSITIONS AND METHODS FOR INHIBITING FIBROSIS

The UAB Research Foundati...

1. A method for reducing idiopathic pulmonary fibrosis in a subject, the method comprising administering to a subject having idiopathic pulmonary fibrosis a therapeutically effective amount of a proline-glycine-proline (PGP)-containing peptide.
US Pat. No. 10,335,449

RHO ASSOCIATED KINASE (ROCK) INHIBITORS AND THEIR USE IN TREATING DISEASE

University of Houston Sys...

1. A method of treating cardiovascular disease and/or conditions involving remodeling comprising administering to a subject in need thereof a pharmaceutical composition comprising (a) a peptide consisting of 4-30 residues and exhibiting the sequence ERTYSPS (SEQ ID NO: 69) and (b) a pharmaceutically acceptable buffer, excipient or diluent.
US Pat. No. 10,335,450

METHODS AND SYSTEMS FOR DELIVERY OF ZW1 HEPTAPEPTIDE

Transdermal Biotechnology...

1. An article for transdermal delivery, the article comprising:a composition comprising ZW1 (SEQ ID NO: 1), a carrier and lecithin.