US Pat. No. 10,188,785

VAGINAL CLEANSING DEVICE

1. A lavage device comprising:a handle, a dressing, and a sterile container;
wherein the lavage device is adapted for use in personal hygiene;
wherein the lavage device is adapted for use with a body cavity;
wherein the dressing is a sterile absorbent dressing that is contained within the sterile container;
wherein the dressing is removed from the sterile container using the handle;
wherein the lavage device separates by distance the non-sterile handle from the sterile surface of the dressing;
wherein the handle comprises a grip and a plug;
wherein the grip is a ring;
wherein the plug is a cylindrical shaft that projects away from the grip;
wherein the plug is further defined with an outer diameter;
wherein the dressing comprises a textile and a port;
wherein the textile is elastic;
wherein the port is a cylindrically shaped cavity that is formed along the center axis of the textile;
wherein the port is further defined with a diameter;
wherein the span of the diameter of the port is less than the span of the outer diameter of the plug when the textile is in a relaxed state;
wherein the plug inserts into the port;
wherein the textile expands when the plug is inserted into the port such that when the textile returns to its relaxed shape a force is applied by the textile to the plug;
wherein the dressing is disposable;
wherein the sterile container comprises a capped tube and a sealing film;
wherein the sealing film attaches to the capped tube
wherein the capped tube is a gas and fluid impermeable structure;
wherein the capped tube is further defined with an open end;
wherein the capped tube is sterilized;
wherein the textile is inserted into the capped tube;
wherein the textile compresses when inserted into the capped tube;
wherein the open end of the capped tube is sealed with the sealing film;
wherein the sealing film is a plastic sheeting;
wherein the plug of the handle is pressed through the sealing film and directly into the port of the textile.

US Pat. No. 10,188,779

IMPLANTABLE PUMP SYSTEM HAVING AN UNDULATING MEMBRANE WITH IMPROVED HYDRAULIC PERFORMANCE

CorWave SA, Clichy (FR)

1. An implantable blood pump system comprising:a housing having an inlet and an outlet and configured to be implanted at a patient's heart;
a membrane disposed within the housing;
a skirt disposed within the housing and coupled to the membrane, the skirt sized and shaped to extend toward the inlet and to curve toward the outlet; and
an actuator disposed within the housing, the actuator configured to cause the membrane to reciprocate and deform in a wave-like manner,
wherein during operation blood enters the inlet, flows toward the skirt which guides the blood towards the membrane, and is propelled across the membrane to the outlet.

US Pat. No. 10,188,778

ARTIFICIAL HEART

Stephen K. Shu, Irvine, ...

1. An artificial heart, comprising:an outer housing comprising a right heart valve plate and a left heart valve plate spaced axially apart by a first bellows spring and a second bellows spring;
a solenoid connected to a first drive coil and a second drive coil, the first drive coil operably connected to the right heart valve plate and the second drive coil operably connected to the left heart valve plate;
a magnet operably connected to a plate structure spaced axially between the first drive coil and the second drive coil, the magnet operably connected to a first end of the first bellows spring and a first end of the second bellows spring, the magnet configured to move axially upon activation of the first drive coil and the second drive coil resulting in conversion of electrical energy to mechanical energy, thereby axially elongating one of the first bellows spring and the second bellows spring and simultaneously contracting the other of the first bellows spring and the second bellows spring resulting in the release of energy, moving blood in or out of the artificial heart by movement of the plate structure;
at least one sensor configured to determine at least one of the position, velocity, and direction of travel of the magnet; and
a servomechanism controller configured to receive data from the sensor and control power to the first drive coil and the second drive coil, thereby actuating the magnet and the plate structure.

US Pat. No. 10,188,777

LIPOSUCTION DEVICE AND SYSTEM AND USE THEREOF

Aurastem LLC, Solana Bea...

1. A device that allows for the removal of adipose tissue with a needle(s), comprising a needle hub that comprises at least one needle having a needle barrel that contains between 1-1000 holes around the circumference of the needle barrel which allows passage of adipose tissue and other lipoaspirate and a guide that prevents the over insertion and under insertion of the needle and thus allows collection of subcutaneous adipose tissue at desired depth,wherein the guide is curved to allow the needle to puncture skin and the needle is adapted to remain in the subcutaneous layer of adipose tissue.

US Pat. No. 10,188,776

NEGATIVE PRESSURE DEVICE

1. Apparatus for providing negative pressure at a wound site, the apparatus comprising:a negative pressure reservoir configured to contain a first zone of negative pressure;
a chamber configured to contain a second zone of negative pressure, the chamber configured to communicate negative pressure to a wound dressing; and
a valve element arranged to selectively provide a fluid communication path between the reservoir and the chamber, the valve element comprising an exterior surface exposed to an ambient atmospheric pressure, an inner surface fixed relative to the exterior surface such that movement of the exterior surface causes movement of the inner surface, a first portion of the inner surface configured to be exposed to the first zone of negative pressure, and a second portion of the inner surface configured to be exposed to the second zone of negative pressure, the valve element further arranged to selectively block the fluid communication path when the exterior surface moves to a first position, the valve element further arranged to selectively open the fluid communication path when the exterior surface moves to a second position, wherein the exterior surface moves from the first position to the second position as a result of the ambient atmospheric pressure acting on the exterior surface and a negative pressure acting on the inner surface.

US Pat. No. 10,188,775

LID FOR A MEDICAL WASTE FLUID COLLECTION AND DISPOSAL SYSTEM

Dornoch Medical Systems, ...

1. A lid for a medical waste collection canister, the lid comprising:a head portion comprising:
three cylindrical suction ports extending along a first, second, and third longitudinal axis, respectively, each suction port having a first diameter and each suction port adapted to be connected to suction tubing and further adapted to receive medical waste through a top of the suction port and pass the medical waste through a bottom of the suction port;
a cylindrical auxiliary vacuum port extending along a fourth longitudinal axis and having a second diameter; and
a plurality of tabs spaced apart along a circumferential edge of the head portion; and
a cylindrical portion coupled to the head portion and extending away from a bottom of the head portion along a fifth longitudinal axis,
wherein each of the suction ports and the vacuum port have a cap that is tethered to the lid, each cap sized to correspond to a size of the suction ports or vacuum port.

US Pat. No. 10,188,771

METHOD OF TREATING PERIPHERAL ARTERY DISEASES IN LOWER LIMBS

TERUMO KABUSHIKI KAISHA, ...

1. A method of treating peripheral artery diseases in lower limbs, comprisinginserting a medical device into a peripheral blood vessel, the medical device comprising a polyamide expandable member possessing a polyamide surface on which a drug coating layer is disposed, the drug coating layer being applied to the polyamide surface of the polyamide expandable member by reverse rotation in which the expandable member is rotated in an opposite direction of dispensing the drug coating layer and in which the drug coating layer is dispensed by a dispenser in contact with the polyamide surface of the expandable member, the drug coating layer having a crystalline morphological form including a plurality of crystal particles of a water-insoluble drug regularly arranged and uniformly sized on the polyamide surface of the polyamide expandable member, each of the crystal particles being independently formed on the polyamide surface of the polyamide expandable member,
expanding the polyamide expandable member,
pressing the drug coating layer to a blood vessel wall of the peripheral blood vessel such that at least part of the plurality of crystals is transferred to the blood vessel wall, and
deflating the polyamide expandable member such that a pharmacokinetics profile is presented in which a drug concentration in the blood vessels is kept for the inhibition of smooth muscle cell proliferation in a first drug-concentration period of time, and for the non-inhibition of endothelial cell growth in a later second drug-concentration period of time, the drug-concentration in the first drug-concentration period of time being higher than the drug-concentration in the second drug-concentration period of time.

US Pat. No. 10,188,770

DENTAL IMPLANT HAVING ENHANCED EARLY STABILITY AND METHOD FOR MANUFACTURING SAME

OSSTEMIMPLANT CO., LTD., ...

1. A dental implant comprising:a hydrophilized roughened surface formed by plasma or ultraviolet treatment; and
an osteoclast activity inhibitor coating film which is formed on the hydrophilized roughened surface of the dental implant to enhance initial stability of the implant and osseointegration at an implant-bone interface,
wherein the osteoclast activity inhibitor comprises at least one selected from the group consisting of alendronate, zolendronate, and pharmaceutically acceptable salts, esters, and acids thereof, and
wherein the osteoclast activity inhibitor coating film further comprises a bone growth factor.

US Pat. No. 10,188,769

BIOCOMPATIBLE SUBSTRATE FOR FACILITATING INTERCONNECTIONS BETWEEN STEM CELLS AND TARGET TISSUES AND METHODS FOR IMPLANTING SAME

UNIVERSITY OF SOUTHERN CA...

1. A method for treating retinal degenerative disease comprising:providing a substrate seeded with cells suitable for implantation into an ocular tissue of a patient, wherein the substrate comprises:
a parylene layer with an apical surface for growth of a population of cells, wherein the parylene layer has a thickness between 0.1 microns and 6 microns;
a plurality of supporting protrusions each extending 1 micron or greater from a basal surface of the parylene layer to a terminating free end of the supporting protrusion;
implanting the substrate into the ocular tissue of the patient; and
positioning the substrate so that the substrate is parallel with an outer nuclear layer of photoreceptors in an eye of the patient.

US Pat. No. 10,188,768

MINIATURE SCENT GENERATING DEVICE

NATIONAL TSING HUA UNIVER...

9. A miniature non-atomizer type scent generating device, comprising:a scented component including a housing, a chamber located in the housing, a ventilation opening penetrating the housing to communicate with the chamber, and a vibration unit disposed in the chamber;
a plurality of solid-state scented particles or microcapsules encapsulating essences disposed in the chamber and having a scent; and
a driving unit comprising a control circuit and connected to the vibration unit;
wherein the vibration unit is controlled by the driving unit to produce a back and forth vibration which directly pushes gas inside the chamber and accordingly induces a unidirectional airflow of perturbation in the chamber;
wherein the unidirectional airflow of perturbation accompanies the solid-state scented particles or microcapsules encapsulating essences flowing through the ventilation opening and out of the chamber to enhance the dispersing of the scent;
wherein the vibration unit comprises:
a piezoelectric film layer;
a first electrode layer, connected to the piezoelectric film; and
a second electrode layer, connected to the piezoelectric film;
wherein the piezoelectric film layer is sandwiched between the first electrode layer and the second electrode layer, and the first electrode layer and the second electrode layer are respectively electrically connected to the driving unit to generate a varying electric field at the piezoelectric film to cause the piezoelectric film layer to produce the vibration.

US Pat. No. 10,188,767

SCENT PRESENTATION METHOD, SCENT PRESENTATION APPARATUS, AND OLFACTION IMPROVING APPARATUS

KEIO UNIVERSITY, Tokyo (...

1. An olfaction improvement method comprising:determining a detection threshold at which a test subject is able to detect a scent selected from among a plurality of scents by
presenting the scent by pulse ejecting the scent for a specified time interval between from about 100 ms to about 300 ms to vary the intensity of the scent,
detecting an operation of a terminal device by the test subject upon detection of the scent by the test subject, and
setting the intensity of the scent detected by the test subject over at least two consecutive trials as the detection threshold of the test subject for each scent from among the plurality of scents, wherein the plurality of scents are selected and presented in a predetermined sequence;
generating a random number to randomly determine a presentation sequence of the plurality of scents;
determining presentation conditions that include the intensity of the scent and the pulse ejection duration of the scent based on the detection threshold of the test subject;
presenting the scent through pulse ejection based on the determined presentation condition; and
altering the presentation conditions by reducing the intensity of the scent, the pulse ejection duration of the scent, or both the intensity of the scent and the pulse ejection duration of the scent relative to the detection threshold of the test subject when presenting the scent at a subsequent time, wherein
the scent is pulse ejected by a fluid ejection device.

US Pat. No. 10,188,766

PURIFIED HYDROGEN PEROXIDE GAS MICROBIAL CONTROL METHODS AND DEVICES

Synexis LLC, Kansas City...

1. A diffuser apparatus for producing non-hydrated purified hydrogen peroxide gas (PHPG) from humid ambient air-comprising:(a) an air distribution mechanism providing an airflow of said humid ambient air;
(b) a source of ultraviolet light; and
(c) a metal, or metal oxide catalyst on a thin, air-permeable substrate structure having a surface,
wherein said air flow is through; said surface and has a residence time on said air-permeable substrate structure of less than a second, wherein said non-hydrated purified hydrogen peroxide gas comprises 0.015 ppm of ozone or less and is directed out of said diffuser apparatus and into an environment when said apparatus is in operation.

US Pat. No. 10,188,765

SUPER DRY FOG GENERATOR

HUBEI HOPE PHARMACEUTICAL...

1. A super dry fog generator comprising a liquid-storage device, an atomization device, an air-blower and a dry separation device; wherein the dry separation device comprises a top and a bottom, and an opening on the top; wherein the dry separation device is above the liquid-storage device and connected with the liquid-storage device; wherein the atomization device is located at an exterior of the liquid-storage device and comprises two ends; wherein the two ends of the atomization device are connected with the air-blower and an interior of the dry separation device, respectively; wherein the atomization device is connected with the liquid-storage device, and a liquid entering into an interior of the atomization device is blown into the interior of the dry separation device by the air-blower, wherein the dry separation device comprises at least two connected cavity structures; and wherein the bottom of the dry separation device is joined to a top of the liquid-storage device and connected with an interior of the liquid-storage device.

US Pat. No. 10,188,764

APPARATUS FOR DISINFECTING AN ENCLOSED SPACE

Nevoa Life Sciences, Sco...

1. An apparatus for disinfecting an area or enclosed space, the apparatus comprising:a device for producing a fog comprising liquid droplets having diameters between about 0.5 micron and about 20 microns;
at least one port for discharging the fog into the area or enclosed space;
an in-line dehumidifying device; and
a low-moisture droplet mesh screen upstream of the dehumidifying device.

US Pat. No. 10,188,762

STERILIZING METHOD AND APPARATUS

Turbett Surgical LLC, Ro...

9. A method of sterilizing, the method comprising:(a) occluding a vent port located on one of a sidewall and a door of a sterilizing cabinet with a filter, the sterilizing cabinet having an internal, port-free, bottom surface;
(b) performing a sterilization cycle on the sterilizing cabinet; and
(c) inducing condensate formed during the sterilization cycle to flow along the port-free, bottom surface of the sterilizing cabinet towards the filter of the vent port located on one of a sidewall and a door of the sterilizing cabinet.

US Pat. No. 10,188,761

GARMENT SANITIZER

KONINKLIJKE PHILIPS N.V.,...

15. A method of sanitizing a garment using a garment sanitizing device comprising a housing, a chamber within the housing to receive one or more garments to be sanitized, the chamber comprising a bottom wall, a top wall, and opposite first and second sides each extending from the bottom wall to the top wall, the housing containing a fan and one or more heating elements, the at least one heating element being disposed proximate the first side of the chamber and an air inlet disposed at the second side of the chamber, the method comprising,placing garments within the chamber,
directly heating the garments within the chamber from the first side of the chamber by radiation from the at least one heating element, and
additionally heating the garments using heated air by activating the fan to convey air via the at least one heating element to heat the air and to convey the heated air through the chamber from the air inlet in the second side of the chamber via air flow passages around an outside of the chamber to converge at a front of the housing towards a front of the chamber to pass through the second side of the chamber to heat the garments.

US Pat. No. 10,188,759

CONJUGATES FOR IMAGING

Endocyte, Inc., West Laf...

1. A conjugate, or a pharmaceutically acceptable salt thereof, of the formula

US Pat. No. 10,188,756

IMAGING HISTONE DEACETYLASES WITH A RADIOTRACER USING POSITRON EMISSION TOMOGRAPHY

The General Hospital Corp...

1. A compound of formula (I):
wherein R1 is a moiety including a substituted or unsubstituted adamantyl group and a contrast agent,
wherein R2 represents hydrogen, or substituted or unsubstituted alkyl, or substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, or substituted or unsubstituted heterocyclic, and
wherein n is an integer selected from 0 or 1, and
wherein the compound has a brain to plasma ratio greater than 1, and wherein at least one atom in R1 is replaced with a positron emitter selected from the group consisting of 11C, 13N, 15O, 18F, 34mCl, 38K, 45Ti, 51Mn, 52mMn, 52Fe, 55Co, 60Cu, 61Cu, 62Cu, 64Cu, 66Ga, 68Ga, 71As, 72As, 74As, 75Br, 76Br, 82Rb, 86Y, 89Zr, 90Nb, 94mTc, 110mIn, 118Sb, 120I, 121I, 122I, and 124I.

US Pat. No. 10,188,753

METHOD FOR INTEGRATING NANOPARTICLES AS PART OF A HYDROGEL MATRIX

Verily Life Sciences LLC,...

1. A method for forming a nanosensor-containing crosslinked polymer, the method comprising:forming a mixture comprising a nanosensor, a crosslinkable polymer precursor, and a surfactant, wherein
the nanosensor comprises a hydrophobic nanoparticle having a detectable label configured to interact with a specific analyte present in a transdermal environment, and
the surfactant comprises one or more chemically-reactive groups capable of forming a covalent bond with the crosslinkable polymer precursor; and
subjecting the mixture to conditions suitable to initiate crosslinking of the crosslinkable polymer precursor, such that the nanosensor is disposed in the crosslinked polymer, and the crosslinked polymer is covalently bound to the surfactant.

US Pat. No. 10,188,745

BINDING PROTEIN DRUG CONJUGATES COMPRISING ANTHRACYCLINE DERIVATIVES

NBE-THERAPEUTICS AG, Bas...

1. A binding protein-drug conjugate (BPDC) comprising an anthracycline (PNU) derivative, the BPDC having the following formula:
wherein
a) each of L1-L3 represents a linker, wherein L1 is optional and both L2 and L3 are mandatory,
b) L1, when present, represents an alkylene-amino linker or an alkylene-diamino linker,
c) L2 represents an oligo-glycine peptide,
d) L3 represents a peptide motif that results from specific cleavage of a sortase enzyme recognition motif,
e) X and Y each represent one or more optional linkers,
f) BP is a binding protein, and
g) n is an integer ?1 and ?10.

US Pat. No. 10,188,743

CYTISINE-LINKED ISOFLAVONOID ANTINEOPLASTIC AGENTS FOR THE TREATMENT OF CANCER

University of Kentucky Re...

1. A method of treating prostate or colorectal cancer, the method comprising administering to a patient in need of prostate or colorectal cancer treatment an effective amount of a cytisine-linked isoflavonoid compound represented by formula (I):
or pharmaceutically acceptable salt thereof or a pharmaceutical composition thereof,
wherein Ar is an aryl or heteroaryl; n is an integer from 1 to 5; each X is independently a halide, or alkoxy, or more than one X on Ar together form a cyclic ether structure; and wherein the compound is substituted on the C-2 position with H, alkyl, cycloalkyl or alkoxy, substituted on the C-5, C-6, C-7, and C-8 positions independently with H, hydroxy (OH), alkyl, cycloalkyl, alkoxy, L is a substituted or unsubstituted di-radical linker group that links the cytisinyl group to either the C-5, C-6, C-7 or C-8 position.

US Pat. No. 10,188,728

COMPOSITIONS AND METHODS FOR TREATMENT OF CANCER

1. A composition for treating cancer comprising targeted liposomes comprising a chemotherapy agent and a sensitizer for the chemotherapy agent, and non-targeted liposomes comprising an anti-angiogenic agent, wherein:said targeted liposomes are immunoliposomes that bind to Her-2/neu;
said chemotherapy agent is doxorubicin, carboplatin, cisplatin, cyclophosphamide, docetaxel, erlotinib, etoposide, fluorouracil, gemcitabine, imatinib mesylate, irinotecan, methotrexate, paclitaxel, sorafinib, sunitinib, topotecan, vincristine or vinblastine;
said sensitizer is verapamil; and
said anti-angiogenic agent is bevacizumab.

US Pat. No. 10,188,718

VACCINES AGAINST STREPTOCOCCUS PNEUMONIAE SEROTYPE 4

1. A saccharide of general formula (I)V*—[Ux+3—Ux+2—Ux+1—Ux]n-V—O-L-NH2  (I)
wherein
x is an integer selected from 1, 2, 3 and 4;
n is an integer selected from 1, 2 and 3;

—V— represents a bond, —Ux+3—, —Ux+3—Ux+2— or —Ux+3—Ux+2—Ux+1—;
V*— represents H—, H—Ux, H—Ux+1—Ux—, H—Ux+2—Ux+1—Ux; and
L represents a linker;
or a diastereoisomer or a pharmaceutically acceptable salt thereof.

US Pat. No. 10,188,709

COMPOSITIONS AND METHODS FOR THE TREATMENT OF PHENYLKETONURIA (PKU)

University of the Science...

1. A pharmaceutical composition comprising a microcapsule, which is enveloped by a membrane comprising ethyl cellulose, and wherein the microcapsule comprises in its interior phenylalanine ammonia lyase and fatty acid-free albumin, wherein the microcapsule has a diameter ranging from about 1 ?m to about 10 ?m.

US Pat. No. 10,188,690

USE OF KAEMPFERIA PARVIFLORA WALL. EX. BAKER EXTRACTS OR FLAVONE COMPOUND FOR PREVENTING OR TREATING MUSCLE DISEASES, OR IMPROVING MUSCLE FUNCTION

AAT COSTECH CO., LTD., S...

1. A method of treating a human suffering from muscle atrophy comprising administering to said human suffering from muscle atrophy a therapeutically effective amount of a compound represented by Formula 4 or salt thereof to the human suffering from muscle atrophy,wherein Formula 4 is as follows:

wherein each of R1, R2, and R3 is independently selected from the group consisting of hydrogen and methoxy, and
wherein the human has a muscle disease selected from the group consisting of atony, muscular dystrophy, myasthenia, and sarcopenia.

US Pat. No. 10,188,682

MEDICAMENT FOR LIVER REGENERATION AND FOR TREATMENT OF LIVER FAILURE

MEDIZINISCHE HOCHSCHULE H...

1. A method of treatment of liver failure and/or for the protection of hepatocytes against apoptosis and/or for the regeneration of hepatocytes, the method comprising a step of administering to a patient in need of treatment a compound, which is an inhibitor of the activity of MKK4, MKK4 being encoded by the mRNA of SEQ ID NO: 1204, wherein the compound is selected from the group consisting of the following compounds:

US Pat. No. 10,188,677

IRON SUPPLEMENT COMPOSITION

THE D DROPS COMPANY INC.,...

1. A composition consisting of:a non-encapsulated iron salt; and
a carrier of a digestible edible oil that is a liquid at 20° C.

US Pat. No. 10,188,674

PARENTERAL FORMULATIONS FOR ADMINISTERING MACROLIDE ANTIBIOTICS

CEMPRA PHARMACEUTICALS, I...

1. A pharmaceutical composition adapted for intravenous administration, the composition comprising one or more antibiotic compounds and a formulating agent, wherein the formulating agent comprises an amino acid selected from the group consisting of arginine, asparagine, aspartic acid, cysteine, glutamine, glutamic acid, histidine, lysine, ornithine, serine, threonine, tryptophan, and tyrosine, and pharmaceutically acceptable salts thereof, and combinations thereof; and where at least one of the one or more antibiotic compounds is of the formula
or a pharmaceutically acceptable salt thereof, wherein:
R10 is hydrogen, acyl or a prodrug moiety;
W is H, F, Cl, Br, I, or OH;
A is CH2, C(O), C(O)O, C(O)NH, S(O)2, S(O)2NH, or C(O)NHS(O)2;
B is C2-C10 alkenylene or C1-C10 alkylene; and
C is hydrogen, hydroxy, acyl, acyloxy, sulfonyl, ureido, or carbamoyl, or alkyl, alkoxy, heteroalkyl, heteroalkoxy, aryl, arylalkyl, heteroaryl, or heteroarylalkyl, each of which is optionally substituted.

US Pat. No. 10,188,671

BORON-DIPYRRIN COMPLEX AND MEDICAMENT CONTAINING THE SAME

JAPAN SCIENCE AND TECHNOL...

1. A boron-dipyrrin complex represented by formula (1)
wherein:
X1 represents a halogenoalkyl group;
X2 represents a halogen atom;
R1 represents a hydrogen atom, an alkyl group, or a group represented by formula (b):

R2 and R6 are the same or different and each represent a hydrogen atom or a halogen atom;
R3, R4, R5, and R7 are the same or different and each represent a hydrogen atom, a halogen atom, or an alkyl group;
R8 represents a hydrogen atom or —(CH2)l—(Y)m—(CH2)n—Z wherein Y represents —CO—, —CONH—, or a triazole ring, Z represents a carboxyl group, a sulfonic acid group, or a —CO— peptide residue, l and n each represent an integer of 1 to 6, and m represents 0 or 1;
R9 and R10 are the same or different and each represent a hydrogen atom, an alkyl group, an alkoxy group, a halogen atom, an amino group, a nitro group, or a cyano group; and
R8 and R10 together optionally form an alkylene group.

US Pat. No. 10,188,665

OCULAR THERAPY USING GLUCOCORTICOID DERIVATIVES SELECTIVELY PENETRATING POSTERIOR SEGMENT TISSUES

Allergan, Inc., Irvine, ...

1. An ophthalmic composition comprising: a therapeutically effective amount of a Glucocorticoid Derivative (GD) comprising an acyl group linked to C17, C21, or combination thereof via an ester linkage, and a viscosity-inducing component.

US Pat. No. 10,188,659

IGF-1R SIGNALING PATHWAY INHIBITORS USEFUL IN THE TREATMENT OF NEURODEGENERATIVE DISEASES

YISSUM RESEARCH DEVELOPME...

1. A method of inhibiting toxic protein aggregation in a subject having a neurodegenerative disease selected from the group consisting of Amyloidosis, Prion disorders, Motor Neuron disease, Alzheimer's disease, Fronto temporal dementia 17 (FTD17), Huntington disease and Parkinson's disease, the method comprising the step of administering to the subject a therapeutically effective amount of a compound represented by the structure of formula I:
wherein
A is H or CN;
Z is S, SO or SO2;
X1, X2, X3, X4, X5, Y1 and Y2 are each independently selected from H, halogen, alkyl, haloalkyl and OR1; and
Y3 and Y4 are each OR1, wherein each R1 is independently H, C1-C4 alkyl, acyl, —(CH2CH2O)nH wherein n is an integer of 1 to 20, or a functional group that gives rise to hydroxyl upon hydrolysis,or salts, hydrates, and solvates thereof.

US Pat. No. 10,188,656

METHODS OF TREATMENT OF MALIGNANCIES

Agios Pharmaceuticals, In...

1. A method of treating acute myeloid leukemia in a subject comprising administering to the subject a mutant isocitrate dehydrogenase 2 (IDH2) inhibitor 2-methyl-1-[(4-[6-(trifluoromethyl)pyridin-2-yl]-6-[2-(trifluoromethyl)pyridin-4-yl]amino-1,3,5-triazin-2-yl)amino]propan-2-ol having the following formula:
or a pharmaceutically acceptable salt, solvate, or tautomer thereof, wherein the acute myeloid leukemia is characterized by the presence of a mutant allele of IDH2 and the absence of a mutant allele of NRAS.

US Pat. No. 10,188,652

COMPOSITIONS AND METHODS FOR TREATING INSOMNIA

1. A method of treating insomnia, comprising administrating orally a dosage form comprising a therapeutically effective amount of compound A, wherein said therapeutically effective amount is a single daily dose ranging from about 2.5 mg to about 10 mg, wherein said single daily dose achieves a mean Cmax of from about 3.0 ng/ml to about 7.2 ng/ml for each 1 mg of compound A after administration to human subjects, and said compound A is (1R,2S)-2-(((2,4-dimethylpyrimidin-5-yl)oxy)methyl)-2-(3-fluorophenyl)-N-(5-fluoropyridin-2-yl) cyclopropanecarboxamide represented by the following formula:

US Pat. No. 10,188,651

METHODS OF TREATING SLEEP DISORDERS

Melior Pharmaceuticals II...

1. A method of treating a sleep disorder associated with altered sleep rhythm and/or architecture in a mammal comprising administering to the mammal in need thereof an effective amount of a compound of Formula Ia-1, Formula Ia-2, Formula Ib-1, Formula Ib-2, Formula Ic-1, Formula Ic-2, Formula Id-1, or Formula Id-2:or a pharmaceutically acceptable salt thereof, wherein the sleep disorder associated with altered sleep rhythm and/or architecture is insomnia, restless legs syndrome, narcolepsy, REM sleep behavior disorder, or disrupted circadian rhythm associated with sleep apnia, shift work, or jet lag; wherein:U is C;
each R1 is, independently, H, C1-C6alkyl, C2-C6alkenyl, C2-C6alkynyl, C1-C6alkoxy, C1-C6alkylthio, —CN, —OH, —SH, halo, haloalkyl, —NO2, —N(?O)2, —C(?O)OH, —NH2, —CF3, —NH(C1-C6alkyl), —N(C1-C6alkyl)2, —C(?O)H, carbalkoxy, carboxamido, alkylsulfonyl, alkylsulfonyloxy, aminosulfinyl, dialkylaminosulfinyl, monoalkylaminosulfinyl, aminosulfonyl, monoalkylaminosulfonyl, dialkylaminosulfonyl, alkylsulfonylamino, hydroxysulfonyloxy, alkoxysulfonyloxy, alkylsulfonyloxy, hydroxysulfonyl, alkoxysulfonyl, alkylsulfonylalkyl, aminosulfonylalkyl, monoalkylaminosulfonylalkyl, dialkylaminosulfonylalkyl, aminosulfinylalkyl, monoalkylaminosulfinylalkyl, or dialkylaminosulfinylalkyl, where r is 0, 1, 2, 3, 4, or 5;
each R2 and R3 is, independently, H, C1-C6alkyl, C2-C6alkenyl, C2-C6alkynyl, C1-C6alkoxy, C1-C6alkylthio, —CN, —OH, —SH, halo, haloalkyl, —NO2, —C(?O)OH, —NH2, —CF3, —NH(C1-C6alkyl), —N(C1-C6alkyl)2, —C(?O)H, carbalkoxy, carboxamido, alkylsulfonyl, alkylsulfonyloxy, aminosulfinyl, dialkylaminosulfinyl, monoalkylaminosulfinyl, aminosulfonyl, monoalkylaminosulfonyl, dialkylaminosulfonyl, alkylsulfonylamino, hydroxysulfonyloxy, alkoxysulfonyloxy, alkylsulfonyloxy, hydroxysulfonyl, alkoxysulfonyl, alkylsulfonylalkyl, aminosulfonylalkyl, monoalkylaminosulfonylalkyl, dialkylaminosulfonylalkyl, aminosulfinylalkyl, monoalkylaminosulfinylalkyl, dialkylaminosulfinylalkyl, aryl, or arylC1-C6alkyl, where n is 0, 1, 2, 3, or 4;
each R4 and R5 is, independently, H, C1-C6alkyl, C2-C6alkenyl, C2-C6alkynyl, C1-C6alkoxy, C1-C6alkylthio, —CN, —OH, —SH, halo, haloalkyl, —NO2, —C(?O)OH, —NH2, —CF3, —NH(C1-C6alkyl), —N(C1-C6alkyl)2, —C(?O)H, carbalkoxy, carboxamido, alkylsulfonyl, alkylsulfonyloxy, aminosulfinyl, dialkylaminosulfinyl, monoalkylaminosulfinyl, aminosulfonyl, monoalkylaminosulfonyl, dialkylaminosulfonyl, alkylsulfonylamino, hydroxysulfonyloxy, alkoxysulfonyloxy, alkylsulfonyloxy, hydroxysulfonyl, alkoxysulfonyl, alkylsulfonylalkyl, aminosulfonylalkyl, monoalkylaminosulfonylalkyl, dialkylaminosulfonylalkyl, aminosulfinylalkyl, monoalkylaminosulfinylalkyl, dialkylaminosulfinylalkyl, aryl, or arylC1-C6alkyl, where p is 0, 1, 2, 3, or 4;
W is H or C1-C6alkyl;
Y is H, C1-C6alkoxy, C1-C6alkylthio, —CN, —OH, —SH, halo, haloalkyl, —NO2, —C(?O)OH, —NH2, —CF3, —NH(C1-C6alkyl), —N(C1-C6alkyl)2, —C(?O)H, carbalkoxy, carboxamido, alkylsulfonyl, alkylsulfonyloxy, aminosulfinyl, dialkylaminosulfinyl, monoalkylaminosulfinyl, aminosulfonyl, monoalkylaminosulfonyl, dialkylaminosulfonyl, alkylsulfonylamino, hydroxysulfonyloxy, alkoxysulfonyloxy, alkylsulfonyloxy, hydroxysulfonyl, alkoxysulfonyl, alkylsulfonylalkyl, aminosulfonylalkyl, monoalkylaminosulfonylalkyl, dialkylaminosulfonylalkyl, aminosulfinylalkyl, monoalkylaminosulfinylalkyl, or dialkylamino sulfinylalkyl;
X is O or S;
Z is O or S;
R7 is H or halo;
Q is H, C1-C6alkyl, aryl, C1-C6alkylaryl, C3-C6cycloalkyl, or heteroaryl, each of which is optionally substituted with —(R6)t, where t is 0, 1, 2, 3, 4, or 5;
R8 is H or C1-C6alkyl; and
each R6 is, independently, H, C1-C6alkyl, C2-C6alkenyl, C2-C6alkynyl, C1-C6alkoxy, C1-C6alkylthio, —CN, —OH, —SH, halo, haloalkyl, —NO2, —N(?O)2, —C(?O)OH, —NH2, —CF3, —O—S(?O)2OH, —NH(C1-C6alkyl), —N(C1-C6alkyl)2, —C(?O)H, —C(?O) C1-C6alkyl, —C(?O) C1-C6alkoxy, carbalkoxy, carboxamido, alkylsulfonyl, alkylsulfonyloxy, aminosulfinyl, dialkylaminosulfinyl, monoalkylaminosulfinyl, aminosulfonyl, monoalkylaminosulfonyl, dialkylaminosulfonyl, alkylsulfonylamino, hydroxysulfonyloxy, alkoxysulfonyloxy, alkylsulfonyloxy, hydroxysulfonyl, alkoxysulfonyl, alkylsulfonylalkyl, aminosulfonylalkyl, monoalkylaminosulfonylalkyl, dialkylaminosulfonylalkyl, aminosulfinylalkyl, monoalkylaminosulfinylalkyl, or dialkylaminosulfinylalkyl; or pharmaceutically acceptable salt thereof.

US Pat. No. 10,188,646

BILE ACID RECYCLING INHIBITORS AND SATIOGENS FOR TREATMENT OF DIABETES, OBESITY, AND INFLAMMATORY GASTROINTESTINAL CONDITIONS

SATIOGEN PHARMACEUTICALS,...

1. A method of treating or preventing obesity by increasing the concentration of bile acid in the distal gastrointestinal tract of a non-diabetic individual, comprising orally administering for local delivery to the distal ileum, the colon, or the rectum of the individual, a therapeutically effective amount of an Apical Sodium-dependent Bile Transporter Inhibitor (ASBTI), and wherein the ASBTI is formulated to be less than 10% systemically absorbed, wherein said ASBTI compound is selected fromand potassium((2R,3R,4S,5R,6R)-4-benzyloxy-6-{3-[3-((3S,4R,5R)-3-butyl-7-dimethylamino-3-ethyl-4-hydroxy-1,1-dioxo-2,3,4,5-tetrahydro-1H-benzo[b]thiepin-5-yl)-phenyl]-ureido}-3,5-dihydroxy-tetrahydropyran-2-ylmethyl)sulphate ethanolate hydrate, or a pharmaceutically acceptable salt or solvate thereof.

US Pat. No. 10,188,644

PROCESS OF MAKING STABLE ABUSE-DETERRENT ORAL FORMULATIONS

COLLEGIUM PHARMACEUTICAL,...

1. A pharmaceutical composition comprising solid microparticles or formulated microparticles prepared by:a. preparing a mixture comprising:
(i) oxycodone, myristic acid, beeswax and carnauba wax, or
(ii) oxycodone in the form of a fatty acid salt, beeswax and carnauba wax at a temperature sufficient to form a substantially homogeneous melt;
b. forming solid microparticles from the substantially homogeneous melt;
c. optionally further formulating the solid microparticles with additional pharmaceutically acceptable excipients to provide formulated microparticles, and
d. curing the solid microparticles or the formulated microparticles at a temperature within the range of 25° C. up to and including the inversion temperature, for a minimum of about 48 hours to provide cured solid microparticles or cured formulated microparticles;
wherein the solid microparticles or the formulated microparticles are cured at a first temperature above the inversion temperature and subsequently a second temperature below the inversion temperature.

US Pat. No. 10,188,642

PHARMACOLOGICALLY ACTIVE COMPOUNDS

Cancer Research Technolog...

1. A compound having the structural formula II shown below:
wherein:
X is CH or N;
Y is N or C—H;
R2 is (1-6C)alkyl, (1-8C)heteroalkyl, aryl, aryl(1-2C)alkyl, a 5 or 6 membered heteroaryl, a 5 or 6 membered heteroaryl(1-2C)alkyl, a 3 to 6 membered heterocyclyl, a 3 to 6 membered heterocyclyl(1-2C)alkyl, (3-8C)cycloalkyl, (3-8C)cycloalkyl(1-2C)alkyl, C(O)R13, C(O)OR13, OC(O)R13, C(O)N(R14)R13, S(O)xR13 (where x is 0, 1 or 2), or SO2N(R14)R13;
and wherein R2 is optionally substituted by one or more substituent groups selected from fluoro, chloro, trifluoromethyl, trifluoromethoxy, cyano, nitro, hydroxy, amino, carboxy, carbamoyl, sulphamoyl, (1-4C)alkyl, (1-4C)alkoxy, S(O)xCH3 (where x is 0, 1 or 2), methylamino or dimethylamino, aryl, aryl(1-2C)alkyl, heteroaryl, heteroaryl(1-2C)alkyl, heterocyclyl, heterocyclyl(1-2C)alkyl, (3-8C)cycloalkyl, and (3-8C)cycloalkyl(1-2C)alkyl,
and wherein any (1-4C)alkyl, (1-4C)alkoxy, aryl, heteroaryl, heterocyclyl, or (3-8C)cycloalkyl moiety present within a substituent group on R2 is optionally further substituted by fluoro, chloro, trifluoromethyl, trifluoromethoxy, cyano, nitro, hydroxy, amino, carboxy, carbamoyl, sulphamoyl, (1-4C)alkyl, NRcRd, ORc, C(O)Rc, C(O)ORc, OC(O)Rc, N(Rd)ORc, C(O)N(Rd)Rc, N(Rd)C(O)Rc, S(O)yRc (where y is 0, 1 or 2), SO2N(Rd)Rc, or N(Rd)SO2Rc, wherein Rc and Rd are each independently H or (1-4C)alkyl;
R3 is hydrogen, (1-4C)alkyl, (3-6C)cycloalkyl, halo, CF3, CN or (1-4C)alkoxy;
R4 is hydrogen, fluoro, chloro or CF3;
Ar has the formula:

wherein:
(i) all of A1, A2 and A3 are CH; or
(ii) A3 is CH and A1 or A2 are N or CH;
R5 is cyano, (1-3C)alkyl, (1-3C)fluoroalkyl, (1-3C)alkoxy, (1-3C)fluoroalkoxy, halo, (1-3C)alkanoyl, C(O)NR15R16 or S(O)2NR15R16, and wherein R15 and R16 are each independently H or (1-3C)alkyl, and wherein any alkyl or alkoxy moities present within a R5 substituent group are optionally further substituted by hydroxy or methoxy;
R6 is halo, trifluoromethyl, trifluoromethoxy, cyano, nitro, hydroxy, amino, carboxy, carbamoyl, sulphamoyl, ureido, (1-6C)alkyl, (2-6C)alkenyl, (2-6C)alkynyl,
or R6 is a group of the formula:
-L1-L2-R17
wherein
L1 is absent or a linker group of the formula —[CR18R19]n— in which n is an integer selected from 1, 2, 3 and 4, and R18 and R19 are each independently hydrogen or (1-2C)alkyl;
L2 is absent or is O, S, SO, SO2, N(R20), C(O), C(O)O, OC(O), CH(OR20), C(O)N(R20), N(R20)C(O), N(R20)C(O)N(R21), S(O)2N(R20), or N(R21)SO2, wherein R20 and R21 are each independently selected from hydrogen or (1-2C)alkyl; and
R17 is (1-6C)alkyl, aryl, aryl-(1-6C)alkyl, (3-6C)cycloalkyl, (3-6C)cycloalkyl-(1-4C)alkyl, heteroaryl, heteroaryl-(1-4C)alkyl, heterocyclyl, or heterocyclyl-(1-4C)alkyl,
 and wherein R17 is optionally further substituted by one or more substituent groups independently selected from oxo, halo, cyano, nitro, hydroxy, NR22R23, (1-4C)alkoxy, (1-4C)alkyl, (3-8C)cycloalkyl, (3-8C)cycloalkyl-(1-3C)alkyl, (1-5C)alkanoyl, (1-5C)alkylsulphonyl, heterocyclyl, heterocyclyl-(1-2C)alkyl, heteroaryl, heteroaryl-(1-2C)alkyl, CONR22R23, and SO2NR22R23; wherein R22 and R23 are each independently selected from hydrogen, (1-4C)alkyl or (3-6C)cycloalkyl or (3-6C)cycloalkyl(1-2C)alkyl; or R22 and R23 can be linked such that, together with the nitrogen atom to which they are attached, they form a 4-6 membered heterocyclic ring ring;
 and wherein when said substituent group comprises an alkyl, cycloalkyl, heterocyclyl or heteroaryl moiety then said moiety is optionally further substituted by hydroxy, fluoro, chloro, cyano, CF3, OCF3, (1-2C)alkyl, (1-2C)alkoxy, SO2(1-2C)alkyl or NReRf (where Re and Rf are each independently hydrogen, (1-3C)alkyl, (3-6C)cycloalkyl, or (3-6C)cycloalkyl(1-2C)alkyl);
or R17 is a group having the formula:
-L3-L4-R24
wherein
L3 is absent or a linker group of the formula —[CR25R26]n— in which n is an integer selected from 1, 2, 3 or 4, and R25 and R26 are each independently hydrogen or (1-2C)alkyl;
L4 is absent or is O, S, SO, SO2, N(R27), C(O), C(O)O, OC(O), CH(OR27), C(O)N(R27), N(R27)C(O), N(R27)C(O)N(R28), S(O)2N(R27), or N(R28)SO2, wherein R27 and R28 are each independently hydrogen or (1-2C)alkyl; and
R24 is (1-6C)alkyl, aryl, aryl-(1-6C)alkyl, (3-6C)cycloalkyl, (3-6C)cycloalkyl-(1-4C)alkyl, heteroaryl, heteroaryl-(1-4C)alkyl, heterocyclyl, or heterocyclyl-(1-4C)alkyl;
R13 is hydrogen, (1-6C)alkyl, (1-6C)alkoxy, (3-6C)cycloalkyl, (3-6C)cycloalkyl-(1-2C)alkyl, aryl, aryl-(1-2C)alkyl, heteroaryl, or heteroaryl-(1-2C)alkyl, and wherein R13 is optionally further substituted by one or more substituents selected from hydroxy, fluoro, chloro, cyano, CF3, OCF3 (1-2C)alkyl and (1-2C)alkoxy;
R14 is hydrogen, (1-6C)alkyl, (3-6C)cycloalkyl, or (3-6C)cycloalkyl-(1-2C)alkyl, and wherein R14 is optionally further substituted by one or more substituents selected from hydroxy, fluoro, chloro, cyano, CF3, OCF3, (1-2C)alkyl and (1-2C)alkoxy;
subject to the proviso that:
X can only be N when Y is N;
when X and Y are both N, R3 is H or fluoro;
or a pharmaceutically acceptable salt or solvate thereof.

US Pat. No. 10,188,641

COMPOSITIONS AND METHODS FOR TREATMENT

SARCODE BIOSCIENCE INC., ...

1. A method of treating dry eye disease in a subject in need thereof comprising administering to the subject an effective amount of a lymphocyte function associated antigen-1 (LFA-1) antagonist or a pharmaceutically acceptable salt or ester thereof, wherein the LFA-1 antagonist is

US Pat. No. 10,188,639

METHODS OF TREATING NEUROLOGICAL, METABOLIC, AND OTHER DISORDERS USING ENANTIOPURE DEUTERIUM-ENRICHED PIOGLITAZONE

DeuteRx, LLC, Andover, M...

1. A method of treating a neurological disorder selected from the group consisting of Parkinson's disease, amyotrophic lateral sclerosis, Friedreich's ataxia, autism spectrum disorder, depression, mild cognitive impairment, Down syndrome, neurodegeneration, adrenoleukodystrophy, Huntington's disease, substance abuse, neuronal injury, and major depression or bipolar disorder cormorbid with metabolic syndrome, comprising administering to a patient in need thereof a therapeutically effective amount of a deuterium-enriched compound of Formula I having an optical purity of at least 75% enantiomeric excess to treat the neurological disorder, wherein Formula I is represented by:
or a pharmaceutically acceptable salt thereof, wherein:
A1, A2, A3, and A4 are independently —C(R9)(R10)—;
A5 is —C(R11)(R12)(R13);
R1, R2, R3, R4, R5, R6, R7, and R8 are independently H or D;
R9, R10, R11, R12, and R13 each represent independently for each occurrence H or D; and
Z is H or D, provided that the abundance of deuterium in Z is at least 30.

US Pat. No. 10,188,638

COMPOUNDS AND COMPOSITIONS FOR INDUCING CHONDROGENESIS

Novartis AG, Basel (CH)

1. A method of treating osteoarthritis or rheumatoid arthritis in a mammal in need thereof, comprising administering to a joint of the mammal a therapeutically effective amount of a compound of Formula IA:or a pharmaceutically acceptable salt, or stereoisomer thereof; wherein“ ”represents a single or double bond;
R0 is selected from hydrogen and C1-6alkyl;
R1 is selected from cyano, 6-membered heterocycloalkyl, 6-membered heterocyclyl, phenyl, and 5- to 9-membered heteroaryl, wherein
the heterocycloalkyl, heterocyclyl, phenyl, or heteroaryl of R1 is unsubstituted or substituted by 1 to 2 substituents independently selected from halo, cyano, C1-6alkyl, C1-6haloalkyl, —C(O)R13, —C(O)O R13, —NR14aR14b5- and 6-membered heterocycloalkyl, phenyl, and 5- and 6-membered heteroaryl; wherein
R13 is selected from C1-6alkyl, amino, and C1-6alkylamino;
R14a and R14b are each independently selected from hydrogen, C1-6alkyl, —C(O)R15, —C(O)OR15, and —S(O)2R15, wherein R15 is hydrogen or C1-6alkyl; and
the heterocycloalkyl, phenyl or heteroaryl substituent of R1 is unsubstituted or further substituted by 1 to 2 substituents independently selected from halo, hydroxy, C1-6alkyl, and C1-6haloalkyl,
R3 is selected from C1-6alkyl, C1-6haloalkyl, 5- and 6-membered cycloalkyl, 5- and 6-membered heterocycloalkyl, 6- and 10-membered heterocyclyl, phenyl, and 5- and 6- membered heteroaryl, wherein
the cycloalkyl, heterocycloalkyl, heterocyclyl, phenyl, or heteroaryl of R3 is unsubstituted or substituted by 1 to 2 substituents independently selected from halo, cyano, C1-6alkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6haloalkoxy, —C(O)R16, —C(O)OR16, - S (O)2R16, 5- and 6-membered heterocycloalkyl, and phenyl; wherein
R16 is hydrogen or C1-6alkyl;
the phenyl or heterocycloalkyl substituent of R3 is unsubstituted or further substituted by 1 to 2 substituents independently selected from halo, and cyano; and
R2 and R4 are each hydrogen or C1-6alkyl; or R2 and R4 taken together form a cyclopropyl ring fused to the bicyclic ring; or R2 and R4 taken together form a bond producing a double bond between the two carbons to which R2 and R4 are attached;
each R5 and R10 is independently hydrogen or C1-6alkyl; or R5 and R10 taken with the atoms to which they are linked form a 5- or 6-membered ring fused to the bicyclic ring; and
R6 and R7 are each hydrogen or C1-6alkyl; or R6 and R7 taken together form a bond producing a double bond between the two carbons to which R6 and R7 are attached;
thereby treating osteoarthritis or rheumatoid arthritis in the mammal.

US Pat. No. 10,188,636

BETAHISTINE FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES

Cipla Limited, Mumbai (I...

1. A method of treating a neurodegenerative disease, comprising administering to a subject in need thereof, a therapeutically effective amount of betahistine or a pharmaceutically acceptable salt thereof, wherein the neurodegenerative disease is Alzheimer's disease and wherein the betahistine or a pharmaceutically acceptable salt thereof is administered orally in an amount from 250-5,000 mg/week with a pharmaceutically acceptable carrier or excipients.

US Pat. No. 10,188,635

USE OF GABOXADOL IN THE TREATMENT OF TINNITUS

OVID THERAPEUTICS INC., ...

1. A method of treating tinnitus comprising administering to a patient in need thereof about 0.05 mg to about 30 mg gaboxadol or a pharmaceutically acceptable salt thereof, wherein the method provides improvement in one or more symptoms of tinnitus in the patient and the improvement is provided for more than 6 hours after administration.

US Pat. No. 10,188,634

3-(3H-IMIDAZO[4,5-C]PYRIDIN-2-YL)-1 H-PYRAZOLO[4,3-B]PYRIDINES AND THERAPEUTIC USES THEREOF

Samumed, LLC, San Diego,...

1. A compound, or a pharmaceutically acceptable salt thereof, of Formula I:
wherein:
R1 and R2 are independently selected from the group consisting of H and halide;
R3 is selected from the group consisting of heteroaryl optionally substituted with 1-4 R6 and -heterocyclyl optionally substituted with 1-10 R7;
R5 is selected from the group consisting of heteroaryl optionally substituted with 1-4 R8, -heterocyclyl optionally substituted with 1-10 R9, and -aryl optionally substituted with 1-5 R10;
each R6 is independently selected from the group consisting of halide, —(C1-6 alkyl), —(C2-6 alkenyl), —(C2-6 alkynyl), —(C1-4 alkylene)pheterocyclyl optionally substituted with 1-10 R11, —(C2-4 alkenylene)pheterocyclyl optionally substituted with 1-10 R11, —(C2-4 alkynylene)pheterocyclyl optionally substituted with 1-10 R11, —(C1-4 alkylene)pcarbocyclyl optionally substituted with 1-12 R12, —(C2-4 alkenylene)pcarbocyclyl optionally substituted with 1-12 R12, —(C2-4 alkynylene)pcarbocyclyl optionally substituted with 1-12 R12, —(C1-4 alkylene)paryl optionally substituted with 1-5 R13, —(C2-4 alkenylene)paryl optionally substituted with 1-5 R13, —(C2-4 alkynylene)paryl optionally substituted with 1-5 R13, —NHC(?O)R14, —NR15R16, —(C1-6 alkylene)NR17R18, —(C2-6 alkenylene)NR17R18, —(C2-6 alkynylene)NR17R18, and —(C1-4 alkylene)pOR24;
each R7 is independently selected from the group consisting of —(C1-4 alkyl), —(C2-4 alkenyl), —(C2-4 alkynyl), halide, —CF3, and —CN;
each R8 is independently selected from the group consisting of —(C1-6 alkyl), —(C2-6 alkenyl), —(C2-6 alkynyl), halide, —CF3, —OCH3, —CN, and —C(?O)R19;
each R9 is independently selected from the group consisting of —(C1-6 alkyl), —(C2-6 alkenyl), —(C2-6 alkynyl), halide, —CF3, —CN, and —OCH3;
each R10 is independently selected from the group consisting of —(C1-6 alkyl), —(C2-6 alkenyl), —(C2-6 alkynyl), halide, —CF3, —CN, —(C1-6 alkylene)pNHSO2R19, —(C2-6 alkenylene)pNHSO2R19, —(C2-6 alkynylene)pNHSO2R19, —NR15(C1-6 alkylene)NR15R16, —NR15(C2-6 alkenylene)NR15R16, —NR15(C2-6 alkynylene)NR15R16, —(C1-6 alkylene)pNR15R16, —(C2-6 alkenylene)pNR15R16, —(C2-6 alkynylene)pNR15R16, and —OR27;
each R11 is independently selected from the group consisting of amino, —(C1-4 alkyl), —(C2-4 alkenyl), —(C2-4 alkynyl), halide, —CF3, and —CN;
each R12 is independently selected from the group consisting of —(C1-4 alkyl), —(C2-4 alkenyl), —(C2-4 alkynyl), halide, —CF3, and —CN;
each R13 is independently selected from the group consisting of —(C1-4 alkyl), —(C2-4 alkenyl), —(C2-4 alkynyl), halide, —CF3, and —CN;
each R14 is independently selected from the group consisting of —(C1-9 alkyl), —(C1-4 haloalkyl), —(C2-9 alkenyl), —(C2-9 alkynyl), -heteroaryl optionally substituted with 1-4 R20, -aryl optionally substituted with 1-5 R21, —CH2aryl optionally substituted with 1-5 R21, -carbocyclyl optionally substituted with 1-12 R22, —CH2carbocyclyl optionally substituted with 1-12 R22, —(C1-4 alkylene)pNR25R26, (C2-4 alkenylene)pNR25R26, —(C2-4 alkynylene)pNR25R26, -heterocyclyl optionally substituted with 1-10 R23, and —CH2heterocyclyl optionally substituted with 1-10 R23;
each R15 is independently selected from the group consisting of H, —(C1-6 alkyl), —(C2-6 alkenyl), and —(C2-6 alkynyl);
each R16 is independently selected from the group consisting of H, —(C1-6 alkyl), —(C2-6 alkenyl), —(C2-6 alkynyl), —CH2aryl optionally substituted with 1-5 R21, and —CH2carbocyclyl optionally substituted with 1-12 R22;
each R17 is independently selected from the group consisting of H, —(C1-6 alkyl), —(C2-6 alkenyl), and —(C2-6 alkynyl);
each R18 is independently selected from the group consisting of H, —(C1-6 alkyl), —(C2-6 alkenyl), —(C2-6 alkynyl), —CH2aryl optionally substituted with 1-5 R21, and —CH2carbocyclyl optionally substituted with 1-12 R22;
each R19 is independently selected from the group consisting of —(C1-6 alkyl), —(C2-6 alkenyl), and —(C2-6 alkynyl);
each R20 is independently selected from the group consisting of —(C1-4 alkyl), —(C2-4 alkenyl), —(C2-4 alkynyl), halide, —CF3, and —CN;
each R21 is independently selected from the group consisting of —(C1-4 alkyl), —(C2-4 alkenyl), —(C2-4 alkynyl), halide, —CF3, and —CN;
each R22 is independently selected from the group consisting of —(C1-4 alkyl), —(C2-4 alkenyl), —(C2-4 alkynyl), halide, —CF3, and —CN;
each R23 is independently selected from the group consisting of —(C1-4 alkyl), —(C2-4 alkenyl), —(C2-4 alkynyl), halide, —CF3, and —CN;
R24 is selected from the group consisting of H, —(C1-6 alkyl), —(C2-6 alkenyl), —(C2-6 alkynyl), —(C1-4 alkylene)pheterocyclyl optionally substituted with 1-10 R23, —(C2-4 alkenylene)pheterocyclyl optionally substituted with 1-10 R23, —(C2-4 alkynylene)pheterocyclyl optionally substituted with 1-10 R23, —(C1-4 alkylene)pcarbocyclyl optionally substituted with 1-12 R22, —(C2-4 alkenylene)pcarbocyclyl optionally substituted with 1-12 R22, —(C2-4 alkynylene)pcarbocyclyl optionally substituted with 1-12 R22, —(C1-4 alkylene)paryl optionally substituted with 1-5 R21, —(C2-4 alkenylene)paryl optionally substituted with 1-5 R21, —(C2-4 alkynylene)paryl optionally substituted with 1-5 R21, —(C1-6 alkylene)pNR25R26, (C2-4 alkenylene)pNR25R26, and (C2-4 alkynylene)pNR25R26;
each R25 is independently selected from the group consisting of H, —(C1-6 alkyl), —(C2-6 alkenyl), and —(C2-6 alkynyl);
each R26 is independently selected from the group consisting of H, —(C1-6 alkyl), —(C2-6 alkenyl), and —(C2-6 alkynyl);
R27 is selected from the group consisting of H, —(C1-6 alkyl), —(C2-6 alkenyl), —(C2-6 alkynyl), —(C1-4 alkylene)pheterocyclyl optionally substituted with 1-10 R23, —(C2-4 alkenylene)pheterocyclyl optionally substituted with 1-10 R23, —(C2-4 alkynylene)pheterocyclyl optionally substituted with 1-10 R23, —(C1-6 alkylene)pNR25R26, —(C2-6 alkenylene)pNR25R26, and —(C2-6 alkynylene)pNR25R26; and
each p is independently an integer of 0 or 1.

US Pat. No. 10,188,629

PRODRUG OF GREEN TEA EPIGALLOCATECHIN-3-GALLATE (PRO-EGCG) FOR USE IN THE TREATMENT OF ENDOMETRIOSIS

1. A method of treating endometriosis or a related indication comprising administering to a subject in need thereof, via enteral or intraperitoneal administration, or an injection into the vagina or uterine cavity, an effective amount of Pro-EGCG having the formula:

US Pat. No. 10,188,627

PPAR AGONISTS, COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE THEREOF

Mitobridge, Inc., Cambri...

1. A compound of Formula (II):
or a pharmaceutically acceptable salt thereof, wherein:
Z is CH, N, or

R1 is —OR1A or —NR1AR1B;
R1A, R1B are each independently hydrogen or C1-C4-alkyl;
W is O, CH2, CH?CH, or C?C;
L is selected from the group consisting of:

Q1 is CR20?CR20, N?CH, CH?N,
or S;Q2 is CR20 or N;
each R20 is independently hydrogen, halogen, C1-C4-alkyl, CN, or C1-C4-alkoxy;
each R10 is independently hydrogen, halogen, C1-C4-alkyl, C1-C4-haloalkyl, C1-C4-alkoxy, C1-C4-haloalkoxy, or C3-C6-cycloalkyl;
p is an integer having a value of 1 or 2; and
R2 is halogen, C1-C4-alkyl, C3-C6-cycloalkyl, CN, C1-C4-alkoxy, C1-C4-haloalkoxy, SO2(C1-C4-alkyl), 5- or 6-membered heterocycloalkyl, -?-R2A, —O(CH2)m,R2B, NH(C1-C4-alkyl), N(C1-C4-alkyl)2, C(O)(C1-C4 -alkyl), optionally substituted aryl, or optionally substituted 5-membered heteroaryl;
m is an integer having an a value of 0, 1, 2, or 3;
R2A and R2B are each independently C1-C4-alkyl, C3-C6-cycloalkyl, or C1-C4 haloalkyl;
R3 is C1-C4-alkyl,

 or C1-C4-haloalkyl; and
with the proviso that the compound is not selected from the group consisting of:

 or a pharmaceutically acceptable salt thereof.

US Pat. No. 10,188,626

STABILIZED CABAZITAXEL FORMULATIONS

Cipla Limited, Mumbai (I...

1. A pharmaceutical composition, comprising a compound having the formula:or a pharmaceutically acceptable salt thereof and at least one solubilizer comprising a caprylocaproyl polyoxylglyceride, wherein the composition is injectable, further comprising albumin.

US Pat. No. 10,188,625

COMBINATION OF A RETINOID AND A DIOL AND POLYUNSATURATED FATTY ACID ESTER

PIERRE FABRE DERMO-COSMET...

1. A combination comprising a retinoid and a compound of the following general formula (I):wherein:n is an integer between 0 and 15,
m is 0, 1, 2 or 3, and
R is the hydrocarbon chain of a polyunsaturated fatty acid selected from omega-3s and omega-6s.

US Pat. No. 10,188,623

ENHANCED BIOAVAILABILITY OF POLYUNSATURATED FATTY ACIDS

Patheon Signals Inc., Hi...

1. An oral pharmaceutical composition comprising an enteric soft capsule shell comprising gelatin and an enteric polymerwherein a weight ratio of the enteric polymer and gelatin is 1:2.6; and
wherein the shell encapsulates a matrix fill comprising at least 94% by weight eicosapentaenoic free fatty acid (EPA) and less than 1% by weight docosahexaenoic acid (DHA).

US Pat. No. 10,188,622

USE OF A COMPOSITION COMPRISING FISH OIL AND JUICE FOR THE TREATMENT AND/OR POST TREATMENT OF CANCER

Smartfish AS, Oslo (NO)

1. A method for treatment and/or post treatment of cancer in a subject in need of treatment thereof, the method comprising administering to the subject a therapeutically effective amount of a composition comprising:a combination of fish oil, and
juice in an oil-in water emulsion,
wherein the fish oil has a totox value below 20 and an omega-3 content above 10% by weight based on the total weight of the fish oil and wherein a suitable emulsifier is used to stabilize the emulsion,
wherein the cancer is selected from the group consisting of prostate cancer, lung cancer, and skin cancer and the post treatment of cancer comprises treatment of cachexia, vitamin D deficiency, fatigue, or stimulation of the immune system, and
wherein said suitable emulsifier is selected from the following group consisting of milk solids, whey protein, oat protein, and pea protein.

US Pat. No. 10,188,610

PROLONGED-RELEASE DIPHENIDOL COMPOSITION

INVEKRA, S.A.P.I. DE C.V....

1. A sustained release diphenidol single layer tablet, consisting of: a) from 15 to 50% diphenidol hydrochloride; b) from 0.1 to 20% of one or more binding agents; c) from 5 to 90% of one or more diluent agents; d) from 5 to 50% of one or more release modification agents; e) from 0.25 to 10% of one or more lubricating agents; and f) 0.1 to 10% of one or more gliding agents, wherein all of the ingredients of the tablet are mixed together prior to tabletting.

US Pat. No. 10,188,608

OXIDIZED CELLULOSE MICROSPHERES

Covidien LP, Mansfield, ...

1. A process for forming microspheres comprising:forming a first plurality of microspheres including at least one bioactive agent and oxidized cellulose;
contacting the first plurality of microspheres with a solution of an aliphatic polyester to form a discontinuous phase liquid;
contacting the discontinuous phase liquid with a continuous phase liquid to form an emulsion; and
extracting a second plurality of microspheres from the emulsion, the second plurality of microspheres including one or more microspheres of the first plurality of microspheres at least partially encapsulated in the aliphatic polyester.

US Pat. No. 10,188,606

EXPANSILE CROSSLINKED POLYMERSOME FOR PH-SENSITIVE DELIVERY OF ANTICANCER DRUGS

Mayo Foundation for Medic...

1. A polymer of Formula (I):
wherein:
each R is independently C1-6 alkyl; and
n is an integer between 1 and 50.

US Pat. No. 10,188,602

BIOERODIBLE IMPLANT FOR LONG-TERM DRUG DELIVERY AND ASSOCIATED METHODS OF MANUFACTURE AND USE

GESEA BIOSCIENCES INC., ...

1. A method for making a core-and-shell type of pellet for controlled release of a pharmacologically active agent, the method comprising:(a) providing (i) an elongated pin comprising two axially aligned, substantially cylindrical adjacent segments of different diameters, with a wider lower segment and a narrower upper segment that terminates in a pin tip, (ii) a pelleting tube having an upper tube opening, an opposing lower tube opening, an inner surface, and an inner diameter sized to provide a sealing fit between the inner surface and the lower segment of the pin, and (iii) a funnel having an outlet aligned with the upper tube opening;
(b) inserting the pin tip into the lower tube opening and moving the pin upward through the tube toward the funnel until the pin tip and upper pin segment protrude from the upper tube opening into the funnel, thereby bringing the lower segment within the tube;
(c) placing a molten shell composition in the funnel;
(d) gradually withdrawing the lower segment from the tube, thereby lowering the upper segment into the tube and simultaneously drawing the shell composition into a concentric space between the upper segment and the inner surface of the tube;
(e) allowing the shell composition to cool and thereby harden into a shell formed around the upper segment within the concentric space;
(f) placing a molten core composition into the funnel; and
(g) gradually lowering the upper segment within the tube, thereby drawing the core composition into the shell to form a core,
wherein the shell composition and/or core composition contain a pharmacologically active agent.

US Pat. No. 10,188,597

HAIR COLOR STAIN REMOVER AND METHOD OF USE

1. A hair color stain remover formula, comprising by volume:a) about 67.9999% Witch Hazel Extract;
b) about 20.0% Glycerin;
c) about 8.8% Distilled Water;
d) about 3.0% Sodium Cocoyl Glycinate;
e) about 0.1% Potassium Sorbate;
f) about 0.1% Sodium Benzoate; and
g) about 0.0001% Green Tea Extract.

US Pat. No. 10,188,594

FERMENTED VEGETABLE OILS AND METHODS OF PREPARING THE SAME

DAMY CHEMICAL CO., LTD., ...

1. A method for preparing a fermented vegetable oil, the method comprising:(a) culturing a yeast in a culture solution at an aerobic condition to form a cultured yeast solution;
(b) adding a vegetable oil to the cultured yeast solution to form a cultured vegetable oil; and
(c) further culturing the yeast in the cultured vegetable oil to ferment the vegetable oil; and
(d) collecting the fermented vegetable oil from the cultured vegetable oil,
wherein the yeast is Pseudozyma SY16, KCTC 8950P,
wherein the free fatty acid content of the fermented vegetable oil formed in step (c) is greater than the free fatty acid content of the vegetable oil added in step (b), and
wherein the culture solution comprises 3 g/l soya bean meal and 0.1 g/l NaCl per liter of the culture solution.

US Pat. No. 10,188,592

2-PYRONES

Merck Patent GmbH, Darms...

1. A cosmetic or pharmaceutical composition comprising at least one compound of the formula (I)
where
R1 stands for a straight-chain or branched C1- to C20-alkyl group,
R2 stands for
H or
straight-chain or branched C1- to C20-alkyl group,
R4 stands for
H,
straight-chain or branched C1- to C20-alkyl group or
straight-chain or branched C2- to C20-alkenyl group having one or more double bonds,
R3 stands for a radical selected from
H,
straight-chain or branched C2- to C20-alkyl group,
straight-chain or branched C2- to C20-alkenyl group having one or more double bonds, where the alkenyl group may also be substituted by one or more saturated or unsaturated C3- to C12-cycloalkyl groups,
straight-chain or branched C2- to C20-alkynyl group having one or more triple bonds,
saturated or partially unsaturated non-aromatic C3- to C12-cycloalkyl group,
where the rings may in each case also be bridged by —(CH2)n— groups where n=1 to 3,
an acyl radical of the formula —C(?O)—R6,
R6 stands for
straight-chain or branched C1- to C20-alkyl group,
a radical of the formula (II)

in which X stands for straight-chain or branched C1- to C6-alkylene or straight-chain or branched C2- to C6-alkenylene and the radicals R5 are selected, independently of one another, from H, OH, straight-chain or branched C1- to C6-alkyl or straight-chain or branched O—(C1- to C6-alkyl),
at least one vehicle which is suitable for a topical application, and
a further anti-ageing or anti-cellulite active compound;
with the proviso that
R4 is a straight-chain or branched C2- to C20-alkenyl group having one or more double bonds or
R3 is a straight-chain or branched C2- to C20-alkenyl group having one or more double bonds, where the alkenyl group may also be substituted by one or more saturated or unsaturated C3- to C12-cycloalkyl groups,
straight-chain or branched C2- to C20-alkynyl group having one or more triple bonds,
saturated or partially unsaturated non-aromatic C3- to C12-cycloalkyl group, where the rings may in each case also be bridged by —(CH2)n— groups where n=1 to 3, or an acyl radical of the formula —C(?O)—R6.

US Pat. No. 10,188,590

SKIN-PROTECTION COMPOSITION CONTAINING DENDROBIUM-BASED INGREDIENTS

Hong Kong Baptist Univers...

6. A method for skin protection against UV exposure, skin damage and aging comprising providing a compound having a formula (5) to a subject in need thereof:whereinR2, R4, and R8 are each independently selected from —OR11, —OCH2R11, —OC(O)R11, —OCH2C(O)OR11 and —OC(O)CH2R11;
R1, R5, R6and R10 are each independently selected from hydrogen;
R3,R7 and R9 are each independently selected from hydrogen, halogen, trifluoromethyl, —OR11 and —OC(O)R11; or R2 and R3, or R7 and R8 may be taken together with the carbon atoms to which they are attached to form a cyclic group;
R11 is independently hydrogen or selected from hydrocarbyl and heterocyclyl, either of which is optionally substituted with 1, 2, 3, 4 or 5 R12;
R12 is independently selected from halogen, trifluoromethyl, cyano, nitro, oxo, —OR13, —C(O)R14, —C(O)N(R13)R14, —C(O)OR13, —OC(O)R14, —S(O)2R13, —S(O)2N(R13)R14, —N(R13)R14;
R13 and R14 are each independently hydrogen or selected from hydrocarbyl and heterocyclyl, either of which is optionally substituted with 1, 2, 3, 4 or 5 substituents independently selected from halogen, cyano, amino, hydroxy, C1-6 alkyl and C1-6 alkoxy;
or a pharmaceutically acceptable salt, prodrug or chemical variant thereof.

US Pat. No. 10,188,586

GASTRIC SYSTEMS, APPARATUS, AND METHODS FOR USE WITH ENTERAL FEEDING

Avent, Inc., Alpharetta,...

1. A gastric pressure relief system comprising:a feeding container connected to an administration tubing;
a relief tubing;
a delivery tube in fluid communication with the administration tubing and the relief tubing;
a multi-way connector having a first arm, a second arm, and a third arm, wherein
the first arm is connected to the relief tubing,
the second arm is connected to the delivery tube, and
the third arm is connected to the administration tubing;
a collection reservoir in fluid communication with the relief tubing, wherein
the collection reservoir includes a vent configured to allow gas to pass through in both directions and configured to restrict the flow of liquid through the vent, wherein the vent comprises a top membrane and a side membrane,
the collection reservoir is configured to collect reflux fluids from a patient's stomach via the relief tubing, and
the collection reservoir comprises volumetric indicia configured to represent a volume of reflux fluids received from the patient's stomach; and
a flow regulator adapted to regulate flow within the relief tubing.

US Pat. No. 10,188,585

DEVICE FOR THE SUBLINGUAL ADMINISTRATION OF A MEDICATION FORMED FROM DISSOLVING A TABLET IN A LIQUID

1. A device for the sublingual administration of a liquid medication formed from dissolving a tablet in a dissolving liquid comprising:an upper portion connected to a lower portion;
the upper portion comprising:
a bottom surface having at least one post and opposite the bottom surface, a cylindrical cavity having a base wall;
a hollow needle having a piercing tip extending upward from the base wall; the cylindrical cavity sized to receive and align an external source containing a dissolving liquid, said hollow needle capable of piercing one end of the external source by the piercing tip;
the lower portion comprising:
a recess sized to accept a tablet of medication, the recess having a base wall having an exit pathway to a discharge located at the side of the lower portion opposite the recess for sublingual administration; and,
when the upper portion and lower portion are connected, the interior space within the recess bordered by the base wall of the upper portion form a chamber having an interior volume and the at least one post sufficiently extends into the chamber to fracture a tablet of medication positioned within the chamber and the needle is a conduit for a dissolving liquid to enter the chamber.

US Pat. No. 10,188,584

MEDICINAL XIDING VIAL AND DISPENSING APPARATUS AND INJECTION APPARATUS THEREOF

1. An assembly of a reversely pressed medicinal vial and a reversely pressed injection apparatus, comprising the reversely pressed medicinal vial and the reversely pressed injection apparatus,wherein the reversely pressed medicinal vial includes a vial body whose inner wall is a straight cylinder, a first piston is disposed on a position close to a vial opening of the vial body, a blind hole is disposed at a center of an outer bottom surface of the first piston, and the vial opening is provided with an outer edge protruding radially outwardly from the vial opening and a seal cap is fixed on the outer edge to prevent the first piston from falling off;
wherein the reversely pressed injection apparatus includes an injection tube, a fixed push rod and an inner needle which longitudinally penetrates the fixed push rod are provided at a bottom center of the injection tube inside the injection tube, a needle head of the inner needle sticks out of the fixed push rod, an outer needle is provided at an outlet port of the injection tube, a tail part of the outer needle is communicated with a tail part of the inner needle, an inner wall of the injection tube is clearance-fitting with the outer edge of the vial opening, and a free end of the fixed push rod is fitted and connected with the blind hole at the center of the outer bottom surface of the first piston,
wherein an annular sealing gasket that is integrated therewith is disposed at the outer bottom surface of the first piston and positioned between the vial opening and the seal cap; and
wherein the free end of the fixed push rod is sleeved with an annular blade, and when the reversely pressed medicinal vial is assembled with the reversely pressed injection apparatus, the annular blade cuts and separates the first piston from the annular sealing gasket, the inner needle impales into the first piston, the first piston is pushed into the vial body in a direction away from the vial opening by the fixed push rod, and the annular sealing gasket is disposed at the vial opening.

US Pat. No. 10,188,582

OUT OF PHASE CHEST COMPRESSION AND VENTILATION

ZOLL Medical Corporation,...

1. A system for providing emergency care to a patient, the system comprising:a backboard arranged to support the patient;
a chest compressor attached to the backboard and positioned to engage the patient at the chest, the chest compressor configured to provide multiple chest compression cycles to the patient, wherein the multiple chest compression cycles are configured to provide a compression of the sternum to a compressed sternal position followed by a hold of the sternum in the compressed sternal position followed by a release of the sternum from the compressed sternal position;
a cuirass attached to the backboard and positioned to engage the patient at the abdomen, the cuirass configured to generate negative pressure to pull outward on the abdomen and to provide multiple abdominal compression cycles to the patient wherein the multiple abdominal compression cycles are configured to provide a compression of the abdomen to a compressed abdominal position followed by a hold of the abdomen in the compressed abdominal position followed by a release of the abdomen from the compressed abdominal position; and
a defibrillator comprising one or more processors configured to:
control the chest compressor to perform the multiple chest compression cycles and the cuirass to perform the multiple abdominal compression cycles according to a programmed sequence such that the compression of the sternum to the compressed sternal position occurs during the hold of the abdomen in the compressed abdominal position and after the compression of the abdomen to the compressed abdominal position and such that the release of the sternum from the compressed sternal position occurs over a pre-determined time interval, and
control the cuirass to generate the negative pressure to pull outward on the abdomen prior to the compression of the abdomen to the compressed abdominal position.

US Pat. No. 10,188,581

METHOD AND SYSTEM TO EVACUATE ONE OR MORE DRESSINGS USING TWO OR MORE VACUUM PUMPS

KCI Licensing, Inc., San...

12. A negative-pressure source, comprising:a first pump;
a second pump;
a first valve having an inlet fluidly coupled to an outlet of the first pump;
a second valve having an inlet fluidly coupled to an outlet of the second pump;
a cross-over valve having a first port fluidly coupled the outlet of the first pump and the inlet of the first valve, and a second port fluidly coupled to the outlet of the second pump and the inlet of the second valve; and
a controller communicatively coupled to the first pump, the second pump, the first valve, the second valve, and the cross-over valve for operation of the first pump, the second pump, the first valve, the second valve, and the cross-over valve.

US Pat. No. 10,188,580

SYSTEMS AND METHODS FOR PROVIDING ENVIRONMENT INFORMATION USING AN UNMANNED VEHICLE

1. A system for providing, to a user, navigation directions to a destination at a destination location, the system comprising:a device worn around a neck of the user and configured to receive an identification of the destination from the user, search for the destination location, and communicate, to an unmanned vehicle, the identification of the destination when the device is unable to determine the destination location; and
the unmanned vehicle for determining the destination location when the device is unable to determine the destination location, the unmanned vehicle having a camera configured to detect image data, and being configured to:
determine an information collecting location,
automatically move to the information collecting location,
detect the image data at the information collecting location,
determine whether the destination is detected from the image data at the information collecting location,
determine the destination location when the destination is detected from the image data at the information collecting location, and
communicate, to the device, the destination location,
wherein the device is further configured to determine and output the navigation directions to guide the user from a current location of the user to the destination location.

US Pat. No. 10,188,579

METHOD FOR CONTROLLING A WALKING ASSISTANT APPARATUS

National Chiao Tung Unive...

1. A method for controlling a walking assistant apparatus, the walking assistant apparatus including a processor, a motion unit, a support unit that is disposed on the motion unit and that includes a handle component operable by a user, a first scanning device disposed on the support unit, and a torque sensor disposed on the handle component, the method comprising the steps of:a) scanning, by the first scanning device, the user so as to generate scanning information associated with gait of the user;
b) detecting, by the torque sensor, a detected torque applied thereto about a vertical axis;
c) estimating, by the processor, a moving speed of the user based on the scanning information;
d) calculating, by the processor, a compliant motion speed based at least on the moving speed of the user, and a compliant rotational speed based on the detected torque detected in step b); and
e) controlling, by the processor, the motion unit to move at the compliant motion speed and to turn at the compliant rotational speed so as to bring the walking assistant apparatus to move at the compliant motion speed and to turn at the compliant rotational speed;
wherein step a) includes scanning the user so as to generate the scanning information that includes a first entry of distance information scanned at a first time instance and a second entry of distance information scanned at a second time instance after the first time instance;
wherein step c) includes the sub-steps of
calculating a first distance between the first scanning device and the user at the first time instance based on the first entry of distance information,
calculating a second distance between the first scanning device and the user at the second time instance based on the second entry of distance information, and
calculating the moving speed of the user based on the first distance, the second distance and a difference between the first time instance and the second time instance; and
step d) includes calculating the compliant motion speed based on the detected torque and the second distance.

US Pat. No. 10,188,578

POWERED HANDLE BAR APPARATUS FOR STAIRCASE, RAMP OR LEVEL WALK AREA WALKING ASSISTANCE FOR CHALLENGED INDIVIDUALS

1. A powered handle bar apparatus for walking assistance comprises:a trolley support bar;
a handle;
a handle operating system;
a control box;
a drive assembly;
an access control reader;
at least one accessory;
a power source;
the trolley support bar being mounted on to a solid surface area;
the control box being terminally connected to the trolley support bar;
the handle being operatively coupled to the trolley support bar by the drive assembly;
the access control reader, the at least one accessory, and the power source being integrated into the control box;
the drive assembly, the access control reader, and the at least one accessory being electrically connected to the power source through the handle operating system;
the at least one accessory comprises a landline phone system;
the landline phone system comprises a phone interface and a phone module;
the phone interface being adjacently connected to the handle;
the phone module being mounted within the control box; and
the phone interface being communicably coupled to the phone module.

US Pat. No. 10,188,576

PIN COVER FOR AN INVERSION TABLE

1. A pin cover for an inversion table comprising:an inversion table;
said inversion table having a fixed frame that is axially connected to a rotating frame;
a pin cover that covers an interface between said fixed frame and said rotating frame;
said pin cover having an inner housing and an outer housing;
said pin cover further includes a slot between said inner housing and said outer housing whereby a portion of said rotating frame rotates on an axis through said pin cover;
said outer housing having at least one pin opening whereby a repositionable pin is inserted to stop rotation of said rotating frame, and
both said inner housing and said outer housing are fixed from rotating in relationship to said fixed frame.

US Pat. No. 10,188,575

CERVICAL ORTHOTIC DEVICE

Core Products Internation...

1. A cervical orthotic device comprising:a base having a length and a width;
sidewalls extending upwardly from the base, wherein the sidewalls include:
opposingly paired lateral sidewalls; and
opposingly paired longitudinal sidewalls:
a cervical support surface opposite said base and uniting said sidewalls, the cervical support surface having a cervical engagement ridge extending parallel with, and in the same direction as, the width of the base, the cervical support surface also including:
a first planar portion adjacent a first longitudinal sidewall of the opposingly paired longitudinal sidewalls and extending therefrom;
a second planar portion adjacent a second longitudinal sidewall of the opposingly paired longitudinal sidewalls and extending therefrom; and
an arcuate portion intermediate the first planar portion and the second planar portion and extending from a first lateral sidewall of the opposingly paired lateral sidewalls to the other lateral sidewall of the opposingly paired lateral sidewalls, the arcuate portion delimiting the cervical engagement ridge for the cervical support surface;
wherein an apex of the cervical engagement ridge defines a height of the cervical orthotic device from the base;
wherein a ratio of a maximum height of the cervical orthotic device to the length is greater than or equal to 1.1575; and
wherein a height of the first longitudinal sidewall of the opposingly paired longitudinal sidewalls is about 1.5 times a height of the second longitudinal sidewall of the opposingly paired longitudinal sidewalls.

US Pat. No. 10,188,574

PATELLA GRIPPER AND DEVICE FOR MOVING A PATELLA COMPRISING SUCH A PATELLA GRIPPER

1. A device for moving a patella with a patella gripper for a patella, comprising:the patella gripper comprising:
a retaining element having a lower face and
a contact finger apparatus, which is arranged on the lower face of the retaining element and is configured to grip the patella,
wherein the contact finger apparatus comprises at least two contact finger units, which are arranged on opposite sides of the retaining element,
wherein the contact finger apparatus is rotatably arranged on the retaining element so that the contact finger apparatus can be rotated on an axis that is aligned perpendicularly to the longitudinal axis of the retaining element and perpendicularly to the transverse axis of the retaining element,
and wherein the contact finger apparatus is adapted to move the patella in one of the cranial-caudal direction and in the medial-lateral direction by the at least two contact finger units;
a leg holding device configured to receive a leg of a patient;
one or more drive units for moving the at least two contact finger units; and
a control unit for controlling the one or more drive units,
wherein the at least two contact finger units are moved linearly with respect to at least one of the retaining element and the leg holding device by the one or more drive units.

US Pat. No. 10,188,573

BOOT STIRRUP

Allen Medical Systems, In...

1. A boot stirrup for use during surgery, the boot stirrup comprisinga support arm having a longitudinal axis,
a surgical boot including a foot support portion formed to support a foot of a patient and a boot handle fixed to the foot support portion, the boot handle extending from a heel support region of the surgical boot, and
a lockable joint coupled to the support arm and coupled to the surgical boot, the lockable joint being configured to move between an unlocked position in which the lockable joint permits movement of the surgical boot along the longitudinal axis relative to the support arm and rotation of the surgical boot about the longitudinal axis relative to the support arm and a locked position in which the lockable joint blocks movement of the surgical boot along the longitudinal axis relative to the support arm and rotation of the surgical boot about the longitudinal axis relative to the support arm, and the lockable joint includes a release lever configured to move relative to the boot handle to unlock the lockable joint, wherein the release lever includes a grip portion that is spaced from the boot handle when the lockable joint is in the locked position and that is adjacent to and in aligned, side-by-side, substantially parallel registry with the boot handle when the lockable joint is in the unlocked position.

US Pat. No. 10,188,571

ADAPTER FOR CONNECTING AT LEAST ONE ACCESSORY DEVICE TO AN OPERATING TABLE

1. An operating table adapter, comprising: a table mount configured to removably attach the adapter to an operating table; and an accessory mount configured to attach a surgery extension device to the adapter; wherein the adapter includes a free-standing, X-ray transparent member; wherein the X-ray transparent member includes a first part comprising a lower surface configured to directly contact an upper support surface of the operating table, and a second part configured to extend beyond the upper support surface in a longitudinal direction of the upper support surface when the adapter is mounted to the operating table via the table mount; wherein the second part of the X-ray transparent member comprises a support surface extension configured to support a patient when the adapter is attached to the operating table; and the table mount comprising: a guide rod, the guide rod being elongated and extending downward with respect to the X-ray transparent member when the adapter is attached to the operating table; and an abutment element, the abutment element being movable vertically along the guide rod towards and away from the X-ray transparent member, and being lockable along the guide rod; wherein when the operating table adapter is positioned on said operating table, the abutment element is movable along the guide rod and lockable against a bottom surface of the operating table, to thereby grasp the operating table between the first part of the X-ray transparent member and the abutment element.

US Pat. No. 10,188,570

METHOD OF REDUCING SURGEON FATIGUE DURING AN OPERATION WHILE REDUCING COLLECTION OF FLUIDS FROM THE OPERATION ON THE FLOOR OF THE OPERATING ROOM BY ABSORBING FLUIDS LEAKING ONTO THE FLOOR OF THE OPERATING ROOM AND APPARATUS THEREFOR

XODUS MEDICAL, INC., , PA...

1. An absorbent, anti-fatigue operating room mat comprising:a support layer to be disposed on the floor of an operating room during performance of an operating room procedure;
a fluid-resistant layer being disposed on top of said support layer during performance of an operating room procedure;
a fluid-absorbent layer being disposed on top of said fluid-resistant layer during performance of an operating room procedure;
a shock-absorbing layer being disposed on top of said fluid-absorbent layer during performance of an operating room procedure;
said shock-absorbing layer comprising shock-absorbing foam material to absorb shocks and reduce fatigue on operating room personnel standing on said anti-fatigue operating room mat;
said shock-absorbing layer comprising holes to permit passage of operating room fluids, generated during performance of an operating room procedure, through said shock-absorbing layer and to said fluid-absorbent layer;
said fluid-absorbent layer comprising a fluid-absorbent material to absorb, capture, contain, and retain operating room fluids that pass through said holes in said shock-absorbing layer to thereby minimize deposition of the operating room fluids on the floor of an operating room;
said fluid-resistant layer comprising a fluid-resistant material to resist the passage of operating room fluids, not absorbed by said fluid-absorbent layer, through and out of said anti-fatigue operating room mat; and
said support layer comprising an anti-skid material to minimize or prevent unwanted sliding or skidding of the anti-fatigue operating room mat on the floor of an operating room during performance of an operating room procedure.

US Pat. No. 10,188,569

PATIENT SUPPORT USABLE WITH BARIATRIC PATIENTS

STRYKER CORPORATION, Kal...

1. A patient support apparatus for supporting a patient, said patient support apparatus comprising:a patient support deck;
a frame supporting said patient support deck;
a pair of wheels coupled to said frame with a width between said wheels being adjustable;
an actuator operatively coupled to said wheels such that operation of said actuator adjusts said width between said wheels; and
a control system configured to determine a condition of at least one of the patient support apparatus and the patient and to control adjustment of said width between said wheels based on said condition.

US Pat. No. 10,188,567

HOSPITAL CHAIR BEDS WITH EXTENDABLE/RETRACTABLE FOOT SECTIONS

1. A hospital bed, comprising:a base comprising opposite end portions;
a lifting mechanism secured to the base between the end portions; and
a patient support surface pivotally secured to the lifting mechanism, wherein the patient support surface comprises a back section, a seat section, and a foot section configured to articulate relative to each other, and wherein the patient support surface is configured to translate from a bed configuration to a chair configuration;
wherein the foot section comprises first, second, third, fourth, and fifth panels operably connected together that are configured to move relative to each other in substantially parallel overlapping planes between an extended configuration when the patient support surface is in a bed configuration and a retracted configuration when the patient support surface is in a chair configuration, wherein the first, third and fifth panels move relative to each other in a first plane, and wherein the second and fourth panels move relative to each other in a second plane.

US Pat. No. 10,188,566

LIFTING MECHANISM

ACCORA LIMITED, (GB)

1. A lifting assembly comprising:a telescopic post assembly including a first tubular member, a second tubular member slidingly engaged with the first tubular member, and a third tubular member slidingly engaged with the second tubular member, the first, second and third tubular members being coaxial;
an actuator configured to move the second tubular member axially with respect to the first tubular member; and
a pulley mechanism comprising:
a first wheel rotatably mounted at a first end of the second tubular member;
a second wheel rotatably mounted at a second end of the second tubular member;
a first length of cable having a first end fixed to the first tubular member and a second end fixed to the third tubular member, the first length of cable being engaged with the first wheel; and
a second length of cable having a first end fixed to the first tubular member and a second end fixed to the third tubular member, the second length of cable being engaged with the second wheel,
wherein the pulley mechanism is arranged such that the movement of the third tubular member relative to the first tubular member is at a greater speed than the movement of the second tubular member relative to the first tubular member.

US Pat. No. 10,188,565

TRANSPORT CHAIRS

The UAB Research Foundati...

1. A wheelchair comprising:a seat assembly comprising a seat having a front edge and a rear edge;
a footrest assembly comprising an upright member having an upper end and a lower end, and a foot plate extending from said upright member near the lower end thereof;
said seat assembly and said footrest assembly pivotally coupled to one another near said front edge and said upper end, defining a single pivot axis therebetween,
said seat assembly and footrest configured to maintain a uniform spatial relationship while pivoting rotationally about said single pivot axis from a first seated position in which said footplate is elevated above a floor to a second seated position at which said foot plate contacts the floor, whereupon said seat assembly is configured to decouple from said footrest assembly and continue pivoting to an inclined position.

US Pat. No. 10,188,564

ABSORBENT ARTICLE COMPRISING FLUID HANDLING ZONES

1. An absorbent article comprising:a. a topsheet comprising a first nonwoven;
b. a backsheet;
c. an absorbent core disposed between the topsheet and the backsheet;
d. a second nonwoven disposed between the first nonwoven and the absorbent core;
e. a first fluid handling zone comprising a first portion of the topsheet and comprising a first Transverse Fluid Travel Distance, wherein the first portion comprises a first macro feature having an area greater than 2 mm2, and a first micro feature having an area less than that of the first macro feature, wherein the first macro feature and the first micro feature comprise apertures extending out of plane;
f. a second fluid handling zone comprising a second portion of the topsheet and comprising a second Transverse Fluid Travel Distance, wherein the second portion comprises a second macro feature that is different than the first macro feature, and wherein the second macro feature has an area of less than 5 mm2;
g. wherein the first Transverse Fluid Travel Distance is greater than the second Transverse Fluid Travel Distance; and
h. wherein the second portion further comprises micro features.

US Pat. No. 10,188,563

ABSORBENT ARTICLES WITH PULPLESS RIFFLED CORE

DSG Technology Holdings L...

1. A disposable absorbent article disposed in a generally flat, open condition, the disposable absorbent article comprising:a central body including an absorbent core, a front longitudinal edge, and a rear longitudinal edge opposite said front longitudinal edge, wherein said front and rear edges of said central body define, at least partially, front and rear waist portions respectively and said central body is characterized by a longitudinal centerline extending across said front and rear edges; and
wherein the absorbent core comprises:
a riffled substrate comprising a plurality of peaks and a plurality of troughs;
a flat substrate coupled to the riffled substrate; and
superabsorbent polymer disposed between the riffled substrate and the flat substrate;
wherein the footprint of the riffled substrate is substantially the same as the footprint of the flat substrate; and
wherein the surface area of the riffled substrate is greater than the surface area of the flat substrate; and
wherein the peaks and troughs of the riffled substrate are spaced apart from the flat substrate.

US Pat. No. 10,188,561

NONWOVEN FABRIC LAMINATE, ABSORBENT ARTICLE HAVING NONWOVEN FABRIC LAMINATE, AND PROCESS FOR PRODUCING NONWOVEN FABRIC LAMINATE

LIVEDO CORPORATION, Ehim...

1. An absorbent article comprising an exterior sheet formed of a plurality of nonwoven fabric layers, whereinthe exterior sheet is located on an outer side of the absorbent article and has a first nonwoven fabric layer, a second nonwoven fabric layer and a third nonwoven fabric layer from the outer side of the absorbent article,
the first nonwoven fabric layer, the second nonwoven fabric layer and the third nonwoven fabric layer are joined to each other at a first joining part by heat-embossing,
the second nonwoven fabric layer and the third nonwoven fabric layer are further joined to each other at a second joining part by heat-embossing, and
the first joining part and the second joining part have a different shape from each other.

US Pat. No. 10,188,560

ABSORBENT ARTICLE HAVING FINGER TABS AND METHODS OF MANUFACTURING SAME

KIMBERLY-CLARK WORLDWIDE,...

1. A method of manufacturing an absorbent article, the method comprising:feeding a first web of material in a machine direction;
feeding a second web of material in the machine direction, the second web being spaced from the first web by a gap;
attaching an absorbent assembly to the first web and the second web such that the absorbent assembly spans the gap between the first and second webs;
forming a partial cut line through the second web, wherein the second web includes opposing side edges extending in the machine direction, the partial cut line spaced from the side edges of the second web;
folding the first web into face-to-face relationship with the second web after forming the partial cut line; and
cutting the first and second webs after folding the first web into face-to-face relationship with the second web to separate the absorbent article from the first and second webs, the partial cut line defining at least one finger tab on the absorbent article.

US Pat. No. 10,188,559

DISPOSABLE DIAPER WITH BUTTOCKS PART STRETCHING UNIT

UNICHARM CORPORATION, Eh...

1. A disposable diaper, comprising:a front waistline region;
a back waistline region; and
a crotch region positioned between the front waistline region and the back waistline region;
a product longitudinal direction oriented from the front waistline region to the back waistline region;
a product widthwise direction orthogonal to the product longitudinal direction:
an absorber running across the crotch region and extending to at least one of the front waistline region and the back waistline region;
a pair of side flaps extending across the front waistline region, the crotch region, and the back waistline region, said pair of side flaps being disposed on opposite sides of the absorber in the product widthwise direction; and
a pair of fastening tapes each extending, in the product widthwise direction, in the back waistline region outward of the pair of side flaps, respectively, said pair of fastening tapes being releasably attachable to the front waistline region;
wherein
each side flap of the pair of side flaps has:
a lateral edge including an leg opening unit concave toward a center of the absorber in the product widthwise direction, said leg opening unit having a center in the product longitudinal direction;
a leg stretching unit disposed inward of the leg opening unit in the product widthwise direction and stretchable in the product longitudinal direction; and
a buttocks part stretching unit running across the crotch region and the back waistline region, and stretchable in the product longitudinal direction;
the leg opening unit in said each side flap has:
a backside leg opening unit positioned backward of the center of the leg opening unit in the product longitudinal direction; and
a foreside leg opening unit positioned forward of the center of the leg opening unit in the product longitudinal direction,
wherein an area between the backside leg opening unit and a straight line, which passes through the center of the absorber in the product widthwise direction and which is parallel to the product longitudinal direction, is larger than an area between the foreside leg opening unit and the straight line, and
in said each side flap,
said buttocks part stretching unit is disposed outward of the leg stretching unit in the product widthwise direction,
a front end of the buttocks part stretching unit is positioned backward of the center of the leg opening unit in the product longitudinal direction and reaches the lateral edge of the side flap, and
a plurality of convex units convex away from the absorber in the product widthwise direction is formed only in the backside leg opening unit and outward of the front end of the buttocks part stretching unit in the product widthwise direction.

US Pat. No. 10,188,558

MALE URINARY INCONTINENCE DEVICE

1. A method of treating urinary incontinence in a human male having a penis having a penis head, the method comprising the steps of:a) providing a wrap configured to absorb urine and having:
i) a distal region configured to absorb urine and comprised of a plurality of layers, the distal region further comprising a front surface, a rear surface opposite the front surface, a distal region left side, a distal region right side, a distal region length extending from the distal region left side to the distal region right side, a distal region proximal end, a distal region distal end, a distal region width extending from the distal region proximal end to the distal region distal end and generally perpendicular to the distal region length;
ii) a lengthwise foldline located at the proximal end of the distal region and extending generally parallel to the distal region length;
iii) a proximal region configured to absorb urine and comprised of a plurality of layers, the proximal region further comprising a proximal region distal end extending from the distal region at the lengthwise foldline, the proximal region further comprising a proximal region proximal end, a proximal region width extending from the proximal region proximal end to the proximal region distal end, a proximal region left side, a proximal region right side, a length extending from the proximal region left side to the proximal region right side;
iv) a left widthwise foldline extending through the proximal and distal regions generally along the proximal and distal region widths; and
v) a right widthwise foldline located to the right of the left widthwise foldline and extending through the proximal and distal regions generally along the proximal and distal region widths,
wherein the front surface of the proximal region left side comprises a left side fastener configured to removably attach to the distal region rear surface, and wherein the front surface of the proximal region right side comprises a right side fastener configured to removably attach to the proximal region rear surface;
b) placing the head of the penis of the male on the proximal region front surface;
c) before or after step b), folding the distal region along the lengthwise foldline so that the distal region front surface faces the proximal region front surface; and
d) folding the left side of the proximal region and the left side of the distal region together along the left widthwise foldline toward the head of the user's penis, attaching the left side fastener to the distal region rear surface, and then folding the right side of the proximal region and the right side of the distal region together along the right widthwise foldline toward the head of the penis, and attaching the right side fastener to the proximal region rear surface,wherein after step d), the right sides of the proximal region and distal region are located in front of the left sides of the proximal region and the distal region and further wherein after steps b) and c), the head of the penis is located between the front surface of the proximal region and the front surface of the distal region.

US Pat. No. 10,188,557

APPARATUS AND PROCESS FOR TRANSFERRING SUBSTRATE MATERIAL AND PARTICULATE MATERIAL

1. An apparatus for making a structure that comprises a combination of a particulate material and a substrate material, including:a) a first moving endless surface with a direction of movement (MD) and with one or more of reservoirs, said first moving endless surface and reservoirs thereof being for transferring particulate material to:
b) a second moving endless surface with a direction of movement (MD) carrying a substrate material for receiving said particulate material from said first moving endless surface in a receiving zone and for transferring said combination of said particulate material and said substrate material in a transferring zone, said second moving endless surface being in said receiving zone adjacent a first vacuum chamber and being in gas communication therewith, and said second moving endless surface being in said transferring zone adjacent a second vacuum chamber, and being in gas communication therewith, said receiving zone and said transferring zone being adjacent (in MD) one another,
c) an adhesive application unit for applying adhesive to said combination of said substrate and said particulate material, said adhesive application unit positioned downstream of said first moving endless surface opposite said second moving endless surface and said second vacuum chamber in said transferring zone;
wherein the ratio of the said negative vacuum pressure in said first vacuum chamber to the negative vacuum pressure in said second vacuum chamber is at least 4:3; and
d) an anvil roll downstream of said transferring zone for receiving said combination of said particulate material and said substrate material and combining said combination with a further substrate material.

US Pat. No. 10,188,556

WOUND BARRIER PAD

1. A sacral wound barrier pad device for treating a wound on a patient, comprising:a first sacral pad having a first internal wall that defines a first interior opening;
a second sacral pad having a second internal wall that defines a second interior opening, wherein said first sacral pad is adhered to said second sacral pad, said sacral pads being aligned such that said first interior opening corresponds generally to said second interior opening so as to permit placement of said sacral wound barrier pad device on a patient such that no sacral pad surface is positioned directly over a wound; and
a resilient, semi-rigid insert situated between said first sacral pad and said second sacral pad, wherein said insert may be at least partially folded whereby when applied to said patient said insert generates an expansion force upon said first sacral pad, said second sacral pad, and skin of said patient to prevent a shearing force from being applied to said wound.

US Pat. No. 10,188,554

WOUND DRESSING

IWMT Intellectual Propert...

1. A wound dressing, for absorbing exudate from a wound on which the wound dressing is placed, comprising:a porous, highly absorptive fiber dressing made up of two or more different types of absorbent material comprising a first absorbent material in the form of a non-woven fabric and a second absorbent material in the form of a woven mesh fabric; and
a negative surface charge on a surface of the dressing, wherein the negative surface charge is created though friction, and further wherein the negative surface charge on the wound dressing attracts positive ions from the wound exudate to form an electric double layer that attracts negative charged particles comprising bacteria and cytokines to the surface of the dressing.

US Pat. No. 10,188,553

DEVICES AND METHODS FOR RESHAPING CARTILAGE STRUCTURES

Chondrocyte, LLC, Hender...

1. A method of shaping a subject's ear to a desired final shape and/or position, the method comprising:lasing the subject's ear so as to stimulate chondrogenesis in the ear;
fitting to the subject's lased ear an integral device comprising:
a first surface configured to fit against and be adhered to the subject's head behind the lased ear, and
a second surface configured to retain the lased ear in a desired final shape and/or position;
wherein, upon fitting of the integral device onto the subject's head and lased ear, the lased ear is maintained in the desired shape and/or position with respect to the subject's head; and
maintaining the integral device on the lased ear until the ear is reshaped to the desired final shape and/or position.

US Pat. No. 10,188,552

SURGICAL SYSTEM PROVIDING HANDS-FREE CONTROL OF A SURGICAL TOOL

The Johns Hopkins Univers...

1. A surgical system providing hands-free control of at least one surgical tool, comprising:a robot having a tool connector;
a smart tool attached to said tool connector of said robot; and
a feedback control system configured to communicate with said smart tool to provide feedback control of said robot,
wherein said smart tool comprises:
a tool comprising a tool shaft having a distal end and a proximal end;
a strain sensor arranged at a first position along said tool shaft;
at least one of a second strain sensor or a torque-force sensor arranged at a second position along said tool shaft, said second position being more towards said proximal end of said tool shaft than said first position; and
a signal processor configured to communicate with said strain sensor and said at least one of said second strain sensor or said torque-force sensor to receive detection signals therefrom,
wherein said signal processor is configured to process said detection signals to determine a magnitude and position of a lateral component of a force applied to said tool shaft when said position of said applied force is between said first and second positions,
wherein said lateral component of said force is a component of said force that lies in a plane that is orthogonal to said tool shaft at said position at which said force is applied, and
wherein said feedback system controls said robot to move in response to at least said magnitude and position of said lateral component of said force applied to said tool shaft when said position of said applied force is between said first and second positions so as to cancel said force applied to said tool shaft to thereby provide hands-free control of said at least one surgical tool.

US Pat. No. 10,188,551

SYSTEMS AND METHODS FOR DELIVERING AN OCULAR IMPLANT TO THE SUPRACHOROIDAL SPACE WITHIN AN EYE

GLAUKOS CORPORATION, San...

1. An ocular implant delivery system, comprising:a generally elongated outer housing;
an elongated insertion needle partially disposed in and extending outwardly from the outer housing, the insertion needle having a lumen;
a pusher tube assembly comprising an implant pusher tube and a pusher tube collar fixedly attached to a proximal portion of the implant pusher tube, a distal portion of the implant pusher tube extending through the lumen of the insertion needle;
a trocar assembly comprising a trocar and a trocar collar fixedly attached to a proximal portion of the trocar, a distal portion of the trocar passing through a lumen of the implant pusher tube;
an implant supported on the distal portion of the trocar, wherein a distal tip of the trocar extends distally beyond a distal-most end of the implant when the implant is supported on the distal portion of the trocar; and
a trocar trigger mechanically coupled to the trocar assembly such that a first actuation of the trocar trigger causes the trocar assembly to move the pusher tube assembly distally relative to the insertion needle to a distal locked position, wherein the implant is exposed from the insertion needle for implantation in a suprachoroidal space of an eye when the pusher tube assembly is at the distal locked position, the trocar trigger being further configured such that a second actuation of the trocar trigger causes the distal tip of the trocar to move proximal to the distal-most end of the implant, thereby releasing the implant from being supported on the distal portion of the trocar.

US Pat. No. 10,188,550

APPARATUS AND METHODS FOR DRUG DELIVERY USING MULTIPLE RESERVOIRS

CLEARSIDE BIOMEDICAL, INC...

1. An apparatus, comprising:a housing;
a cartridge assembly, at least a portion of the cartridge assembly configured to be movably disposed in the housing, the cartridge assembly including a first movable member and a second movable member, the second movable member including a seal member configured to form a fluidic seal with an inner surface of the first movable member, the first movable member defining an inner volume bounded by the seal member and the inner surface of the first movable member, at least a portion of the second movable member being movably disposed in the inner volume between a first position and a second position relative to the first movable member;
a first reservoir disposed within the inner volume such that the first reservoir is disposed in a distal position relative to the second movable member, the first reservoir containing a drug when the second movable member is in its first position relative to the first movable member, the first reservoir not being in fluid communication with the inner volume when the second movable member is in its first position, the first reservoir being placed in fluid communication with the inner volume when the second movable member is in its second position relative to the first movable member, the first movable member including a valve member configured to be transitioned from a closed configuration when the second movable member is in its first position relative to the first movable member to an open configuration (1) when the second movable member is moved toward its second position relative to the first movable member, and (2) in response to an increase in pressure within the first reservoir by distal movement of the second movable member from its first position towards its second position, the valve member further configured to be transitioned from the open configuration to the closed configuration after the second movable member is moved towards its second position relative to the first movable member; and
a second reservoir at least partially defined by the housing, a portion of the first movable member being movably disposed in the second reservoir, the second reservoir being fluidically isolated from the inner volume when the second movable member is in its first position relative to the first movable member and the valve member is in its closed configuration, the second reservoir being placed in fluid communication with the inner volume when the second movable member is moved toward its second position relative to the first movable member to receive a volume of the drug from the first reservoir and the valve member is in its open configuration, the first movable member and the second movable member collectively configured to be moved distally from a first position relative to the housing to a second position relative to the housing to expel the volume of the drug from the second reservoir.

US Pat. No. 10,188,549

EXOTHERMIC THERAPEUTIC NATURAL MASSAGE SHELLS

FOREVER YOUNG INTERNATION...

1. An exothermic natural massage shell, comprising:a natural bivalve shell comprising a first half and a second half adhered together with an adhesive to form a hollow chamber;
an aperture formed in the first half to provide a portal to the hollow chamber of the bivalve shell;
an exothermic reactant disposed inside the hollow chamber of the bivalve shell, the reactant being removably inserted through the portal;
wherein the reactant is combined with an activator inside the hollow chamber of the bivalve shell which causes an exothermic reaction that heats the bivalve shell and maintains the bivalve shell at a substantially constant elevated temperature for a duration of time, the hollow chamber and the portal being reusable for repeated exothermic reactions wherein addition of water to the reactant inside the hollow chamber creates an exothermic gel that transfers heat to one or more walls of the halves of the natural bivalve shell; and
wherein the adhesive adhering the first half of the bivalve shell to the second half of the bivalve shell comprises a first elastomeric polymer bonding agent with coefficient of expansion properties operable to maintain first and second halves securely adhered through repeated heating and cooling cycles and a second flexible resin sealant that makes the adhesive moisture-proof.

US Pat. No. 10,188,548

ARTIFICIAL HYPOTHALAMUS FOR BODY TEMPERATURE REGULATION

National Guard Health Aff...

1. An artificial hypothalamus system comprising:a plurality of sensors;
a thermal management system configured to apply optimal temperature regulation via one or more of a fan and a temperature adjustment mechanism; and
a control system, communicably coupled to the plurality of sensors, and the thermal management system, wherein circuitry of the control system is configured to
determine if sensor data from the plurality of sensors is in a predetermined normal range,
convert the sensor data to fuzzy values when the sensor data is not in the predetermined normal range,
combine one or more related consequents of the predetermined fuzzy rules, wherein the consequent is determined based on the evaluation of an antecedent,
evaluate the combined consequents to determine a centroid value using a centroid method, and
transmit the centroid value to the thermal management system to activate the thermal management system to a predetermined activation level based on the centroid value.

US Pat. No. 10,188,547

APPARATUS AND METHOD FOR USING A PORTABLE THERMAL DEVICE TO REDUCE ACCOMMODATION OF NERVE RECEPTORS

CAREWAVE MEDICAL, INC., ...

1. A heating device for therapeutically heating skin to reduce accommodation of thermal nerve receptors, comprising:a heat delivery element adapted to be worn proximate to the skin of a user; and
a microprocessor control unit configured to control the heat delivery element;
wherein the microprocessor control unit is programmed to maintain at least one cycle of skin temperature having:
a ramp-up temperature period,
a peak temperature,
a ramp-down temperature period, and
a soak temperature,
wherein the soak temperature is lower than the peak temperature, and wherein the soak temperature is greater than a body temperature.

US Pat. No. 10,188,546

INTRAUTERINE DEVICE WITH CONTROLLED COPPER ION ELUTION

SEBELA VLC LIMITED, Hami...

1. An intrauterine contraceptive device with a controlled ion release rate, the contraceptive device comprising:only one elongate shape memory member sized to fit completely within a human uterus and comprising a first metal having a first galvanic potential, wherein the elongate shape memory member further comprises;
a bottom loop disposed at a bottom of the contraceptive device;
multiple twists located above the bottom loop, forming a spring portion;
a middle portion comprising two parts of the elongate shape memory member extending upward from the multiple twists to form an oval shape;
two bends in the elongate shape memory member at a location above the oval shape of the middle portion, wherein the bends cause the elongate member to cross over itself;
two arms extending from the two bends in opposite directions, wherein one of the arms extends from one of the two bends and the other arm extends from the other of the two bends;
a first end loop forming a first tissue contact surface at an end of one of the two arms; and
a second end loop forming a second tissue contact surface at an end of the other of the two arms, wherein the intrauterine contraceptive device is configured such that, when it is delivered into the human uterus, only the first and second tissue contact surfaces contact the human uterus; and
multiple substance delivery sleeves coupled with the elongate shape memory member and comprising a second metal having a second galvanic potential different from the first galvanic potential, wherein the multiple substance delivery sleeves are coupled with the elongate shape memory member at locations to locally deliver a substance to the uterus in an area near a fallopian tube and an area near a cervical os, the multiple substance delivery sleeves comprising:
at least a first sleeve disposed around the elongate shape memory member on one of the two arms near the first end loop;
at least a second sleeve disposed around the elongate shape memory member on the other of the two arms near the second end loop; and
at least a third sleeve disposed around the elongate shape memory member and threaded within the bottom loop,
wherein the first metal and the second metal are configured to control a galvanic potential difference between the elongate shape memory member and the multiple substance delivery sleeves and thereby provide the controlled ion release rate.

US Pat. No. 10,188,545

FLEXIBLE CONE-SHAPED INTRA-VAGINAL SUPPORT DEVICE

WATKINS-CONTI PRODUCTS, I...

11. A vaginal insert device for use in improving symptoms associated with pelvic organ prolapse, urinary incontinence, or both pelvic organ prolapse and urinary incontinence, comprising:an upper portion, which is made of an elastic and non-absorbent material, having a cone-shaped body, having a circular transverse cross-section throughout a length of the upper portion, having a wall with an interior side and an exterior side, an upper open end, a lower end, and a hollow interior, wherein a circumference of the upper portion decreases from the upper open end to the lower end, wherein the upper open end of the upper portion is the innermost portion of the vaginal insert device during insertion, and wherein the wall of the upper portion is configured to be squeezed to make the upper portion into a more compact shape for easier insertion of the vaginal insert device, and wherein said wall expands hack to its original shape alter the insertion;
an exterior rim surrounding and protruding from the exterior side of the wall of the upper portion, the exterior rim being adjacent to said upper open end;
a plurality of ridges surrounding and protruding from the exterior side of the wall of the upper portion, the plurality of ridges being spaced apart from the upper open end to the lower end, wherein the plurality of ridges are distributed along an entire length of the upper portion from the lower end to the exterior rim;
wherein said upper portion, with said exterior rim and said plurality of ridges, hold the vaginal insert device securely in place to impose pressure on the urethral sphincter, or to support pelvic organs, or to both impose pressure on the urethral sphincter and support pelvic organs, when the device is inserted; and
a stem extending from said lower end of said upper portion, wherein the upper portion and the stem comprise an integral one-piece device made from said elastic and non-absorbent material, wherein the stem is configured to be accessed from the exterior of a vagina when the vaginal insert device is inserted in said vagina, and wherein said stem assists in removal of the vaginal insert device.

US Pat. No. 10,188,544

PENILE IMPLANT

POWELL DEVELOPMENT GROUP,...

1. A penile implement comprising:a top film;
a bottom film adhered to the top film such that a reservoir exists between the top film and bottom film, wherein each of the top film and bottom film are distinct films that are welded, or glued to one another;
an adhesive layer formed on the bottom film;
a bottom release layer covering at least a portion of the adhesive layer; and
wherein a hole is formed in the bottom film, whereby during use, a user may remove the bottom release layer and adhere the bottom film with a user's penis such that bodily fluids secreted from the user's penis pass through the hole and into the reservoir formed between the top film and bottom film.

US Pat. No. 10,188,543

FOLDING MENSTRUAL CUP

Guangzhou Tianyuan Silico...

1. A folding menstrual cup comprising:an outer cup body with a top and a bottom, wherein a top accommodating cavity is formed inside the outer cup body and a round opening is provided at the top of the outer cup body; at a side opposite to the opening, the bottom of the outer cup body is connected to a flow guiding pipe via a folding part;
the flow guiding pipe with a pipe orifice in communication with the top accommodating cavity of the outer cup body, where a valve controlling communication to the pipe orifice is arranged on the flow guiding pipe; and
the folding part being capable of protruding upward and enabling the top end of the flow guiding pipe to extend into the top accommodating cavity of the outer cup body along with the folding part; wherein the folding part is capable of straightening downward and a bottom accommodating cavity is formed inside the folding part.

US Pat. No. 10,188,542

COMPLETE FLOW DIVERSION INTESTINAL OSTOMY SURGERY KIT

Jianjiang Lin, Hangzhou ...

1. A flow diversion intestinal ostomy surgery kit, comprising:at least an ostomy tube, said ostomy tube comprising: a tube body; near the front end of the tube body a deformable balloon; said tube body forming a drainage section at a preceding part of the balloon; a fine tube is provided within a tube wall of said tube body or inside said tube body; a front end of the fine tube penetrates the tube wall of said tube body and is in communication with an inner cavity of the balloon; a rear end of the fine tube connects a connector for injecting fluid into the balloon with a one-way valve; said connector is equipped with a manometer for measuring pressure caused by the balloon impressed to the intestinal wall; said balloon and an intestinal wall form a sealed structure that blocks matters inside of an intestine after filled with fluid via said connector; there is a drainage port at the drainage section for guiding matters inside of the intestine out by said tube body;
wherein said flow diversion intestinal ostomy surgery kit further comprises a ring-shaped fixing plate; an exterior wall of the tube body is provided with a ring-shaped groove; said ostomy tube is fixedly connected to an abdominal wall of a patient via the ring-shaped fixing plate that matches the ring-shaped groove;
wherein an inner ring of said ring-shaped fixing plate is provided with four jaws configured to touch the ostomy tube body and extending along a diameter of said ring-shaped fixing plate, said jaws provided in pairs with an end of each jaw configured to be directly across the ostomy tube body from another jaw end, a space between ends of the four jaws is slightly smaller than an outer diameter of said tube body, said ring-shaped fixing plate stuck in said ring-shaped groove by way of pressing said jaws.

US Pat. No. 10,188,541

IMMOBILIZING SPLINTS

1. An immobilizing splint for an antecubital intravenous injection site, the splint comprising:a sleeve of a flexible foam material configured to be selectively and removably closed around an elbow of an arm of a patient;
a preformed opening in the sleeve configured to allow visual access to an antecubital fossa of the elbow, wherein the preformed opening has a presized perimeter that is closed and continuous;
at least two straps configured to close the sleeve around the elbow, wherein each strap of the at least two straps includes a hook-and-loop fastener; and
two stiffening members configured to maintain the elbow in an at least substantially extended position when the sleeve is closed around the elbow to prevent a kink in a portion of an intravenous supply tube that underlies the splint when the sleeve is closed around the elbow, wherein the stiffening members are positioned in the sleeve on opposite sides of the preformed opening such that, when the sleeve is closed around the elbow in a position that allows visual access to the antecubital fossa through the preformed opening, the stiffening members are positioned on an anterior side of the arm.

US Pat. No. 10,188,540

SACROILIAC BELT

BRACE FIT LLC, Owariasah...

1. A sacroiliac belt comprising a belt pair that forms a pelvic holding loop to hold a user's pelvis from a buttock side or a lumbar back side, entirely wrapping the pelvis, the belt pair comprising:a ring-shaped ilium belt (A) configured to be wound around the user's waist, surrounding the user's right and left ilia; and
a second belt selected from:
either a buttock belt (B1) configured to be wound around the user's waist passing under the user's buttocks, lifting up the buttocks; or
a lumbar belt (B2) configured to be wound around the user's waist passing the user's lumbar back, which is a back side of the user's lumbar curve located immediately above the pelvis, wherein:
the second belt is shorter than the ilium belt,
the sacroiliac belt comprises rings at both ends of the second belt,
while the ilium belt placed through the rings, the both ends of the second belt each connected to the ilium belt in a pair of connection areas placed inside both ends of the ilium belt through a reversible connection through which the both ends of the second belt are reversibly connected to the pair of connection areas on the ilium belt via touch fasteners that consist of first and second components, the first components attached in the connection areas on the ilium belt, the second components attached on the both ends of the second belt the first components have widths within which positions of connection between the first and second components are adjustable,
the second belt comprises:
a band-shaped main portion;
the rings, and
a pair of connection portions each comprising the second components of the touch fasteners, and connected to both ends of the main portion via the rings,the both ends of the main portion and the connection portions each attached to the rings in a movable manner along rims of the rings, andthe rings are placed more inside the both ends of the second belt than the second components are.

US Pat. No. 10,188,539

STABILIZING SYSTEM FOR A KNEE BRACE

SpringLoaded Technology I...

1. A knee brace for assisting the extension or flexing of a limb, comprisingsubstantially rigid upper and lower frames connected by a hinge,
the upper frame comprising hinge arms each having one end connected to the hinge and an opposite end connected to the other hinge arm by an upper leg bearing member for bearing against a user's leg above the knee,
the lower frame comprising first and second hinge arms extending in a first direction and each having one end connected to the hinge and an opposite end connected to the other hinge arm by a lower leg bearing member for bearing against the user's leg below the knee, a first strap support being provided on the first hinge arm and an opposing second strap support being provided on the second hinge arm,
at least one upper securing member for fixing the upper frame to the user's leg, and
a stabilizing strap for fixing the lower frame to the user's leg, the stabilizing strap comprising a substantially inelastic element for circumscribing the user's leg and a fixing element for securing the inelastic element in a set position, the inelastic element extending through the first and second strap supports, such that when the brace is in use the stabilizing strap is inhibited from moving relative to the lower frame in the first direction to support the lower frame on the user's leg and is slidable relative to the lower frame in a second direction that is orthogonal to the first direction, wherein when the knee brace is in use the stabilizing strap follows the user's leg motion in the second direction without shifting the lower frame relative to the user's leg in the first direction.

US Pat. No. 10,188,538

HYBRID TRIGGER WIRE FOR ENDOGRAFTS

Cook Medical Technologies...

1. An endovascular prosthesis delivery system comprising:an inner cannula;
a prosthesis comprising graft material releasably secured to the inner cannula, the prosthesis having a radially-inwardly contracted delivery configuration and a radially-expanded deployed configuration, wherein the prosthesis comprises at least two suture loops secured to an outer surface of the prosthesis and circumferentially spaced from each other;
a releasable trigger wire extending along at least a portion of a length of the prosthesis, wherein the releasable trigger wire extends through the graft material and into a graft lumen, wraps around a circumference of the inner cannula, extends back through the graft material to exit the graft lumen and extends through at least one of the at least two suture loops to retain the prosthesis in the radially-inwardly contracted delivery configuration.

US Pat. No. 10,188,537

APPARATUS FOR FOLDING OR UNFOLDING A MEDICAL IMPLANT, AND IMPLANT

Venus Medtech (Hangzhou) ...

1. A foldable and/or unfoldable medical implant comprising:at least three tension threads for folding and/or unfolding the implant; and
at least one first ring having a channel for guiding some or all of the tension threads around the implant at an outside or an circumference thereof, wherein three of the tension threads are wound along or around the outside or circumference of the implant in a manner such that each part of the outside or circumference is covered or contacted by two of the tension treads,
the medical implant further comprises at least a second ring having a channel, and at least three posts, the at least three posts being arranged between the first ring and the second ring in order to connect them with each other and/or to maintain the distance between them, each of the at least three posts having at least two openings through which the tension threads are guided from an inside of the implant to an outside of the implant and back from the outside to the inside, wherein the tension threads are guided to the outside through a first opening of a first one of the posts and back to the inside through a second opening of a second one of the posts, the first opening being different from the second opening, and the first post being different from the second post.

US Pat. No. 10,188,535

MEDICAL DEVICES HAVING ENHANCED PERFORMANCE

Boston Scientific Scimed,...

1. A medical device, comprising:an expandable framework of oriented polymer fibers, wherein a binding polymer portion of one polymer fiber and a fibrous polymer reinforcement portion of another polymer fiber form a reinforced composite region, wherein the fibrous polymer reinforcement portion comprises, relative to a longitudinal axis of the framework, one of the following fractions, any two of the following fractions, or all three of the following fractions:
a first fraction oriented at a first angle relative to the longitudinal axis;
a second fraction oriented at a second angle relative to the longitudinal axis; and
a third fraction oriented at a third angle relative to the longitudinal axis.

US Pat. No. 10,188,534

STENT HAVING REDUCED PASSAGE OF EMBOLI AND STENT DELIVERY SYSTEM

Covidien LP, Mansfield, ...

1. An expandable tubular stent for implantation in a body lumen comprising:a structural portion extending along an axis being radially expandable thereabout and having a first expanded percentage open area, the structure portion including a plurality of struts; and
a barrier portion affixed to the structural portion and having a second expanded percentage open area, the barrier portion including a plurality of pores extending therethrough, the barrier portion being at least partially made of metal;
the stent having a composite expanded percentage open area within a range of 65% to 95%, wherein the composite expanded percentage open area is calculated by finding a difference between an area of the pores of the expanded barrier portion and an area of said pores occluded by the struts of the expanded structural portion, and dividing said difference by surface area of the expanded stent.

US Pat. No. 10,188,533

MINIMAL SURFACE AREA CONTACT DEVICE FOR HOLDING PLAQUE TO BLOOD VESSEL WALL

Intact Vascular, Inc., W...

1. An intravascular device comprising:a frame consisting of only a single column of cells, the frame comprising:
a pair of concentric side rings comprising a single distal undulating ring and a single proximal undulating ring spaced apart coaxially from each other, each of said pair of concentric side rings having a compressed state and an expanded state and forming one end of the device; and
a plurality of longitudinally extending bridge members connecting the pair of concentric side rings, wherein each bridge member of the plurality of longitudinally extending bridge members connects to one of the pair of concentric side rings at one end and to the other of the pair of concentric side rings at an opposite end of the device; and
each of the bridge members comprising two pointed barbs extending from the bridge members in at least one of a circumferential manner and a tangential manner, wherein each of the two pointed barbs has a V-shape structure, and wherein a pointed end of the V-shape structure is pointed in a direction perpendicular to the longitudinal axis of the device;
wherein each cell of the single column of cells comprises a portion of each of the pair of concentric side rings and two of the plurality of longitudinally extending bridge members.

US Pat. No. 10,188,532

BLOOD-FLOW TUBING

Vascular Flow Technologie...

1. An intravascular stent comprising:a tubular member having an internal surface and an external surface,
wherein the tubular member has an internal helical formation to induce spiral-flow therethrough, and wherein the internal helical formation is provided on a portion of the internal surface and the internal surface extends beyond said portion,
wherein the internal helical formation has a helix angle between 5 and 50 degrees relative to a longitudinal axis of the stent, and wherein the tubular member is selected from the group consisting of:
(a) a tubular mesh member;
(b) a tubular member formed from a wire; or
(c) a tubular member of a mesh material that is formed from expanded sheet.

US Pat. No. 10,188,531

PROSTHESIS SOCKET WITH A RIGID STRUCTURE ARRANGED BETWEEN AN INTERNAL DEFORMABLE LAYER AND AN EXTERNAL DEFORMABLE LAYER

POMMIER ORTHOPEDIE, Vill...

1. A socket to interface a lower limb which has undergone amputation and a modular element, to be fastened to the socket at a distal end the socket comprising:an internal deformable layer consisting of silicone rubber, designed to be in contact with the lower limb that has undergone amputation;
an external deformable layer consisting of silicone rubber; and
a rigid structure arranged between the internal deformable layer and the external deformable layer,
wherein the socket extends along a longitudinal direction from a proximal end to the distal end, said proximal end defining an outer opening of the socket through which the lower limb that has undergone amputation is received, and
wherein the rigid structure comprises at least two posts and a base, each post extending along the longitudinal direction of the socket from the base located at the distal portion to an end of the post such that a distance from the end of the post to the proximal end of the socket is less than half a length of the post along said longitudinal direction, wherein ends of the at least two posts are not linked, so that the ends separate and approach each other due to an effect of a deformation of the internal layer and of the external layer, wherein the at least two posts and the base of the rigid structure are made together from a single monolithic rigid material, and
wherein, between two successive posts of the at least two posts, a first part of the external deformable layer is in contact with a first part of the internal deformable layer and wherein each of the at least two successive posts separates a second part of the external deformable layer from a second part of the internal deformable layer.

US Pat. No. 10,188,530

PROVISIONAL TIBIAL PROSTHESIS SYSTEM

Zimmer, Inc., Warsaw, IN...

1. A tibial prosthesis system for implantation on a resected surface of a proximal tibia, the tibial prosthesis system comprising:a bearing component having a superior surface and an inferior surface;
a base component having a superior surface and an inferior surface, wherein the base component having a protrusion extending from the superior surface and configured to mate with a recess in the bearing component, the protrusion having a first feature configured to couple with a second feature of the bearing component when the protrusion is inserted into the recess to prevent significant relative movement between the bearing component and the base component in a medial/lateral direction and an anterior/posterior direction, and wherein the first feature and the second feature are configured to allow the bearing component to be movable relative to the base component in a proximal/distal direction; and
a shim component insertable between the inferior surface of the bearing component and the superior surface of the base component, wherein upon insertion the shim component is configured to engage both the bearing component and the base component to restrain the bearing component from significant relative movement in the proximal/distal direction relative to the base component, and wherein the shim component is configured to be disposed between the inferior surface of the bearing component and the superior surface of the base component.

US Pat. No. 10,188,529

DEVICES AND METHODS FOR INTER-VERTEBRAL ORTHOPEDIC DEVICE PLACEMENT

1. An instrument assembly for delivery of an orthopedic implant to a target location within a spinal segment of a subject, comprising:an orthopedic implant;
an implant insertion member comprising a first elongated curvilinear body and an internal bore, at least a portion of said internal bore is extended from a proximal opening to a distal opening along a curvilinear trajectory, said internal bore configured for advancement of said orthopedic implant from said proximal opening to said distal opening; and
a fixation member comprising a first segment configured to attach onto a proximal segment of said implant insertion member, and a second segment configured to attach onto a first surface of said spinal segment, said fixation member configured to limit movement of said implant insertion member relative to said target location in at least one plane;
wherein said orthopedic implant is sized to be advanced from said proximal opening to said distal opening of said internal bore and onto said target location.

US Pat. No. 10,188,528

INTERVETERBRAL DISC PROSTHESIS INSERTION ASSEMBLIES

LDR Medical, Rosieres Pr...

1. An intervertebral disc prosthesis insertion assembly having a longitudinal axis extending from an insertion end of the intervertebral disc prosthesis insertion assembly to a tool-attachment end of the intervertebral disc prosthesis insertion assembly and comprising:an intervertebral disc prosthesis;
a pin having a central axis and an insertion tool coupler; and
an insertion adapter comprising
a first arm comprising a first jaw disposed along the insertion end and a first tang disposed along the tool-attachment end, and
a second arm comprising a second jaw disposed along the insertion end and a second tang disposed along the tool-attachment end;
the intervertebral disc prosthesis insertion assembly having
an assembled configuration in which the pin is inserted into the first arm and the second arm with the central axis extending in the direction of the longitudinal axis, the first jaw and the first tang disposed on a first side of the central axis, the second jaw and the second tang disposed on a second side of the central axis opposite the first side, and the intervertebral disc prosthesis retained between the first jaw and the second jaw by the insertion of the pin into the first arm and the second arm, and
a released configuration in which the pin is outside the first arm and the second arm and the intervertebral disc prosthesis is released from the first jaw and the second jaw.

US Pat. No. 10,188,527

EXPANDABLE AND ADJUSTABLE LORDOSIS INTERBODY FUSION SYSTEM

SPINEEX, INC., Fremont, ...

1. A spinal implant device for placement between vertebral bodies, the device comprising:an expandable shell;
at least one wedge member;
at least one drive shaft; and
the expandable shell comprising a top member and a bottom member, at least the bottom member having tracking for receiving the at least one wedge member, the at least one drive shaft engaging with the at least one wedge member for moving the at least one wedge member along the tracking, the at least one wedge member engaging the top member and the bottom member, the at least one wedge member comprising a tapered configuration having an external helical thread, whereby the top member and bottom member move relative to each other in response to rotation of the at least one wedge member along the tracking to effect an expansion of the shell, the tracking comprising a cascading series of risers on interior surfaces of each of the top and bottom members, the cascading series of risers comprising individual riser members increasing in height along the interior surfaces and delivering corresponding staggered spaces in between the individual riser members so that the individual riser members and the corresponding spaces on the top member overlap the individual riser members and the corresponding spaces on the bottom member, permitting an interlocking engagement of the top and bottom members when the top and bottom members are in a contracted position, whereby the cascading series of risers on the interior surface of the top member intermesh with the cascading series of risers on the interior surface of the bottom member, and wherein the tracking is configured to increase a longitudinal position of the at least one wedge member along and relative to the interior surfaces of the top and bottom members within the shell as it travels along the tracking whereby the at least one wedge member engages the top and bottom members to selectively contact the shell.

US Pat. No. 10,188,526

SPINAL IMPLANT SYSTEM AND METHOD

Warsaw Orthopedic, Inc., ...

15. A surgical instrument comprising:a tubular shaft;
a first rotatable arm connected with the shaft;
a second rotatable arm connected with the shaft; and
a drive rod translatable relative to the shaft and including at least one ramp that is translatable relative to the shaft to engage and rotate the arms relative to the shaft between a capture orientation and a release orientation with an interbody implant,
the rod being engageable with the interbody implant to move at least a portion of the interbody implant between a contracted configuration and an expanded configuration.

US Pat. No. 10,188,525

SPINAL IMPLANT SYSTEM AND METHOD

Warsaw Orthopedic, Inc., ...

1. A spinal implant comprising:a substantially cylindrical member; and
an implant body extending between an anterior surface and a posterior surface, and including a first vertebral engaging surface and a second vertebral engaging surface,
the implant body further including an inner surface that defines a portion of a first cavity and a portion of a second cavity spaced from the first cavity,
the first cavity being oriented to implant a fastener oblique relative to a bilateral axis of a subject body and the second cavity being oriented to implant a fastener in substantial alignment with the bilateral axis,
wherein the inner surface further defines a transverse bore, the member being disposed entirely within the transverse bore, and
wherein the member includes a threaded surface defining a portion of the first cavity and a threaded surface defining a portion of the second cavity.

US Pat. No. 10,188,524

ROTATIONAL DRIVE MECHANISM, TOOL AND METHODS FOR USING SAME

AESCULAP IMPLANT SYSTEMS,...

1. A spinal interbody device, comprising:a front surface;
a rear surface substantially opposed to the front surface;
an upper surface connected to the front surface and the rear surface;
a lower surface opposed to the upper surface and connected to each of the front surface and the rear surface;
at least one opening formed at the front surface, the at least one opening extending through the front surface;
at least one projection; and
a drive mechanism disposed adjacent the at least one opening and configured to move the at least one projection so that the at least one projection moves through at least one of the upper surface and the lower surface, the drive mechanism including a cam plate,
wherein the at least one opening formed at the front surface includes at least one first camming groove and the cam plate includes at least one second camming groove defined therein for retaining and guiding the at least one projection when the front surface is disposed adjacent to the cam plate, and at least one of the first camming groove and second camming groove is a spiral slot.

US Pat. No. 10,188,523

PROSTHETIC ANKLE COMPONENTS

Biomet UK Healthcare Limi...

1. A first prosthetic ankle component comprising:a first bearing surface configured to slidably engage a second bearing surface of a second prosthetic ankle component when in an installed configuration; and
one or more protrusions protruding from the first bearing surface, the protrusions being configured to be received by one or more corresponding receiving portions provided on the second prosthetic ankle component,
wherein the one or more protrusions are further configured such that the interaction with the receiving portions permits the first and second prosthetic ankle components to slide with respect to one another in an interface plane defined by the interface between the first and second bearing surfaces, and wherein the protrusions are further configured to restrict the first and second prosthetic ankle components moving away from one another in a direction with a component perpendicular to the interface plane, and wherein the protrusion includes an abutment surface configured to abut a closed end of the of the second prosthetic ankle component to limit a sliding movement in a first direction; and
wherein the first prosthetic ankle component further comprises a lip, the lip being provided at or towards an edge of the first bearing surface, the lip being configured to limit sliding movement of the first and second prosthetic ankle components in a second direction which is opposite the first direction by having an abutment surface configured to abut a surface of the second prosthetic component, wherein the abutment surface of the protrusion and the abutment surface of the lip are opposed to and facing each other so as to limit sliding movement in both the first direction and the second direction which is opposite the first direction.

US Pat. No. 10,188,522

SYSTEM FOR REPLACEMENT OF AT LEAST A PORTION OF A CARPAL ARTICULAR SURFACE OF A RADIUS

TOBY ORTHOPAEDICS, INC., ...

1. A system for replacement of at least a portion of a carpal articular surface of a radius, the system comprising:a prosthesis having a plate-like portion and at least one portion, said plate-like portion having an exterior surface formed thereon, and said at least one portion being positioned opposite from said exterior surface and being adapted to directly contact an interior portion of the radius, said at least one portion having at least one aperture provided therein, said exterior surface being sized and shaped to approximate the surface of the at least a portion of the carpal articular surface of the radius, and said at least one aperture of said at least one a portion of said prosthesis being adapted to receive at least one fastener therein;
a bone plate having a first end an opposite second end, and a length and a longitudinal axis extending between said first end and said second end, said bone plate having a width perpendicular to the length of said bone plate, said bone plate having an upper surface, a lower surface, and a thickness extending between said upper surface and said lower surface, said lower surface being adapted to contact an exterior of the radius, said bone plate having at least one opening passing from said upper surface through said lower surface and being configured to receive said at least one fastener therethrough, at least a portion of said bone plate being configured to be attached to the radius proximate of the distal end thereof, said bone plate and said at least one portion of said prosthesis being spaced from one another when said system is assembled and being adapted to clamp a portion of the radius between said lower surface of said bone plate and said at least one portion of said prosthesis via said at least one fastener drawing said bone plate and said at least one portion of said prosthesis toward one another; and
said at least one fastener having a first end for insertion through said at least one opening and into said at least one aperture, said at least one fastener being configured to secure attachment of said prosthesis and said bone plate to one another across a portion of the radius.

US Pat. No. 10,188,521

MULTIPLE-CAM, POSTERIOR-STABILIZED KNEE PROSTHESIS

MEDIDEA, LLC, Ann Arbor,...

1. A total knee replacement system comprising:a distal femoral knee-replacement component and a tibial component having a bearing surface and a tibial post with a posterior surface, wherein the distal femoral knee-replacement component comprises:
a body having a pair of medial and lateral condylar protrusions and an intercondylar region therebetween dimensioned to receive the tibial post, the body further having a cam mechanism bridging the intercondylar region, the cam mechanism having at least a first, second and third cam surface areas, with each of the first, second and third cam surface areas having a convex shape in a sagittal plane with different centers of radius;
the first convex cam surface area engaged with the posterior surface of the tibial post at approximately ninety degrees of flexion;
the second convex cam surface area being located anterior to the first cam surface area, when the knee is in extension and positioned posterior of the tibial post; and
the third convex cam surface area being located posterior to the first cam surface area, when the knee is in extension, and engaging the posterior surface of the tibial post after ninety degrees of flexion;
wherein none of the first, second and third cam surface areas engage the posterior surface of the tibial post when the knee is in extension; and
wherein the cam mechanism includes at least one concave cam surface area in the sagittal plane between at least two of the three convex cam surface areas.

US Pat. No. 10,188,520

MODULAR LATERAL HIP AUGMENTS

Biomet Manufacturing, LLC...

1. A femoral implant for a hip, comprising:a proximal femoral body implant comprising:
a proximal femoral body portion;
a distal stem coupled to the proximal femoral body portion; and
a femoral head coupled to a neck portion of the proximal femoral body portion;
a lateral plate having a T-shaped configuration coupled to a lateral side of the proximal femoral body implant, the lateral plate comprising:
a lateral surface and a medial surface configured to be positioned adjacent to at least the lateral side of the proximal femoral body implant, at least one of the medial and lateral surfaces of the lateral plate defining a soft tissue attachment surface;
a projection extending from the medial surface and being configured to mate with a recess formed in the lateral side of the proximal femoral body implant;
an aperture formed in the lateral plate and extending through the projection such that the aperture is configured to be coaxially aligned with a lateral bore formed in the proximal femoral body implant; and
at least one threaded bore extending from one of the lateral surface or the medial surface, the threaded bore being configured to receive a plate fastener for securing soft tissue to the lateral plate; and
an implant fastener configured to be received through the aperture and configured to be threadably secured to the lateral bore of the proximal femoral body implant to couple the lateral plate to the proximal femoral body implant, the fastener having a length sufficient to also pass through a portion of the femur for securing the portion of the femur to the lateral plate and the proximal femoral body implant,
wherein the recess is coaxial with the lateral bore formed in the proximal femoral body implant,
wherein the projection includes a tapered cylindrical portion and the recess includes a complementary shaped tapered counterbore adapted to receive the tapered cylindrical portion in a press fit configuration, and
wherein the lateral plate further comprises a proximal end adapted to extend a distance beyond a proximal end of the proximal femoral body implant, the proximal end of the lateral plate including a sharp projection configured to attach the lateral plate to the soft tissue.

US Pat. No. 10,188,518

ANNULOPLASTY RING WITH VARIABLE CROSS-SECTION

Edwards Lifesciences Corp...

15. An elongated annuloplasty ring, comprising:an elongated ring body comprising an inner single piece metallic structural support surrounded by a suture permeable interface, the ring body surrounding a central open area through which passes a flow axis and being discontinuous so as to define two free ends at a break in continuity around a periphery of the ring body, wherein the ring body has a relaxed configuration shaped to mimic a three-dimensional path along a non-planar native valve annulus,
wherein the structural support has a radial cross-section that gradually changes around a length of the structural support and has a C-shaped part in a mid-portion, and wherein the two free ends of the structural support are rectangular in radial cross-section and are more flexible in bending about the flow axis than the C-shaped part of the cross-section, and wherein the two free ends of the ring body are axially offset from each other.

US Pat. No. 10,188,517

INVERSION DELIVERY DEVICE AND METHOD FOR A PROSTHESIS

HLT, Inc., Maple Grove, ...

1. A method for inverting an invertible device comprising:advancing a first predetermined length of an invertible device distally from a delivery catheter, thereby establishing a target position;
limiting movement of said first predetermined length of said invertible device, thereby keeping said first predetermined length at said target position; and,
distally advancing a second predetermined length of said invertible device from said catheter so as to invert said second predetermined length into said first predetermined length.

US Pat. No. 10,188,516

STENT LOADING TOOL AND METHOD FOR USE THEREOF

Medtronic Ventor Technolo...

1. A loading system for loading a valve prosthesis into a delivery catheter, the loading system comprising:a loading tool comprising a loading tool connection member, wherein the loading tool connection member comprises a first plurality of prongs, wherein the loading tool connection member includes an open state with the first plurality of prongs flared outwardly and a closed state with the first plurality of prongs radially contracted;
a valve prosthesis including a radially compressed configuration and a radially expanded configuration, the valve prosthesis comprising valve prosthesis connection members configured to removably engage with a respective one of the first plurality of prongs, wherein the loading tool is configured to engage the valve prosthesis with the valve prosthesis in the radially expanded configuration and the loading tool in the open state; and
a crimping tool comprising a proximal end and a distal end, wherein the diameter of the distal end is greater than the diameter of the proximal end,
wherein the loading tool connection member, in the open state while engaged with the valve prosthesis in the radially expanded configuration, is configured to pass through the crimping tool such that the valve prosthesis crimps from the radially expanded configuration to the radially compressed configuration and the loading tool connection member radially contracts from the open state to the closed state.

US Pat. No. 10,188,515

DEVICES AND METHODS FOR CRIMPING A MEDICAL DEVICE

MEDTRONIC VASCULAR INC., ...

1. A system for crimping a prosthetic valve comprising:a first funnel, the first funnel comprising a first diameter of the first funnel, a tapered section, and a second diameter of the first funnel smaller than the first diameter of the first funnel;
a second funnel, the second funnel comprising a first diameter of the second funnel, a tapered section, and a second diameter of the second funnel smaller than the first diameter of the second funnel;
a delivery device, the delivery device comprising a strut support and an outer sheath, at least a portion of the delivery device extending through the first funnel and the second funnel wherein
the second diameter of the first funnel and the second diameter of the second funnel face towards each other,
the second diameter of the first funnel engages with the second diameter of the second funnel, and
the first diameter of the first funnel and the first diameter of the second funnel face away from each other; and
an actuator comprising a handle, a channel, a pull ring, and at least one wire operatively attached to the pull ring, an end of the at least one wire configured to attach to the prosthetic valve and pull the prosthetic valve through at least one of the first funnel and the second funnel through sliding of the pull ring;
wherein the first diameter of the first funnel is larger than the first diameter of the second funnel.

US Pat. No. 10,188,514

TRANSCATHETER VALVE PROSTHESIS

HIGHLIFE SAS, Paris (FR)...

1. A heart valve system, the system comprising:a radially self-expandable tubular body having an inflow end and an outflow end, the tubular body including a plurality of beams at the outflow end of the tubular body; and
a valve coupled to the outflow end of the tubular body such that an entirety of the valve is distal of the inflow end of the tubular body, the valve including a plurality of valve leaflets,
wherein:
each valve leaflet is supported by only two beams of the plurality of beams,
connection points link the inflow end of the tubular body and the plurality of beams, a number of connection points being equivalent to a number of the valve leaflets, and
each beam of the plurality of beams is directly connected to an adjacent beam so that the plurality of beams extends the entire circumferential length of the tubular body at the outflow end.

US Pat. No. 10,188,513

PROSTHETIC TISSUE VALVES

CORMATRIX CARDIOVASCULAR,...

1. A prosthetic valve for modulating fluid flow through a cardiovascular structure during cardiac cycles of a heart, said fluid flow exhibiting a plurality of positive and negative flow pressures during said cardiac cycles, said prosthetic valve comprising:a valve structure comprising a remodelable conical shaped sheet member, said sheet member comprising an extracellular matrix (ECM) composition, said ECM composition comprising acellular ECM from a mammalian tissue source,
said sheet member further comprising an open proximal annulus engagement end configured to engage said cardiovascular structure and receive said fluid flow therein and a closed distal end,
said sheet member further comprising a plurality of linear interstices disposed between said sheet member open proximal annulus engagement end and said closed distal end, wherein said plurality of linear interstices do not extend to said closed distal end,
said sheet member being configured to transition from an expanded position when said proximal annulus engagement end of said sheet member is engaged to said cardiovascular structure and receives said fluid flow therein, and said fluid flow exhibits a first positive flow pressure of said plurality of positive flow pressures, to a collapsed position when said fluid flow exhibits a first negative flow pressure of said plurality of negative flow pressures,
said plurality of linear interstices being configured to transition from an open position, when said sheet member is in said expanded position, to a closed position, when said sheet member is in said collapsed position,
said closed distal end of said sheet member being configured to block said fluid flow therethrough when said plurality of linear interstices are in said open and closed positions, wherein when said plurality of linear interstices are in said open position, said plurality of linear interstices allow said fluid flow to be transmitted through said plurality of linear interstices and sheet member, and wherein when said plurality of linear interstices are in said closed position, said plurality of linear interstices and said closed distal end of said sheet member jointly block said fluid flow through said sheet member,
said sheet member being further configured to remodel, and induce host cell and tissue proliferation, remodeling of damaged cardiovascular tissue and regeneration of new cardiovascular tissue and tissue structures with site-specific structural and functional properties, when said proximal annulus engagement end of said sheet member is engaged to said cardiovascular structure, wherein said proximal annulus engagement end of said sheet member is disposed proximate damaged tissue of said cardiovascular structure; and
a biodegradable multi-link support stent structure disposed in said sheet member.

US Pat. No. 10,188,512

REVERSIBLE CAVITARY TENSION MEMBRANE

1. An apparatus for supporting and uniformly covering at least in one plane a cavity structure without obstructing the flow of fluid through the cavity structure, the apparatus comprising:an expandable membrane configured to transition between an expanded state and a shrunken state, wherein the membrane is comprised of a first layer and a second layer, the edges of which are joined together to create a closed chamber between the first layer and the second layer, the membrane comprising:
an internal face and an external face opposite the internal face;
a tension mechanism disposed between the internal face and the external face and configured to exert force on the first layer and the second layer to place the expandable membrane in the expanded state;
and at least one orifice disposed between the internal face and the external face, wherein the external face is in fluid communication through the orifice with an empty space defined by the internal face of the membrane when the membrane is in the expanded state.

US Pat. No. 10,188,511

BIOPROSTHETIC TISSUE WITH REDUCED CALCIFICATION

Edwards Lifesciences Corp...

1. A packaged bioprosthetic device comprising:an at least partially cross-linked pericardial tissue comprising functional groups that have been blocked, removed or altered by reacting the functional groups with capping agents, wherein the functional groups are one or both of aldehyde groups and carboxylic acid groups; and
a packaging storing the at least partially cross-linked biological tissue without a liquid preservative solution.

US Pat. No. 10,188,510

PROSTHETIC TISSUE VALVES

CorMatrix Cardiovascular,...

1. A prosthetic valve for modulating fluid flow through a cardiovascular structure during cardiac cycles of a heart, said fluid flow exhibiting a plurality of positive and negative flow pressures during said cardiac cycles, said prosthetic valve comprising:a remodelable biological tissue structure comprising a continuous tubular member,
said tubular member comprising an adaptive tissue regeneration system configured to engage said cardiovascular structure and induce modulated healing of damaged cardiovascular tissue of said cardiovascular structure concomitantly with stress-induced hypertrophy of said tubular member when said tubular member is subjected to cardiac cycle induced physical stimuli,
said modulated healing of said damaged cardiovascular tissue comprising inflammation modulation of said damaged cardiovascular tissue and induced neovascularization, remodeling of said damaged cardiovascular tissue and regeneration of new cardiovascular tissue and tissue structures with site-specific structural and functional properties,
said stress-induced hypertrophy of said tubular member comprising adaptive remodeling of said tubular member, wherein said tubular member remodels and forms functioning valve structures that are similar to native valve structures,
said adaptive tissue regeneration system comprising a tubular member material component and a tubular member physical structure component,
said tubular member material component comprising an extracellular matrix (ECM) composition, said ECM composition comprising acellular ECM from a mammalian tissue source,
said tubular member physical structure component comprising a sheet member comprising a proximal valve annulus engagement end and a distal end, said proximal valve annulus engagement end of said sheet member being configured to engage a valve annulus region of said cardiovascular structure,
said proximal valve annulus engagement end comprising a circumferential ribbon connection region and a plurality of equally spaced ribbons projecting from said circumferential ribbon connection region toward said sheet member distal end,
each of said plurality of ribbons comprising proximal and distal ends, a first edge region extending from said proximal end of each of said plurality of ribbons to said distal end of each of said plurality of ribbons and a second edge region extending from said proximal end of each of said plurality of ribbons to said distal end of each of said plurality of ribbons,
said proximal end of each of said plurality of ribbons being connected to said circumferential ribbon connection region,
said plurality of ribbons being positioned circumferentially about said circumferential ribbon connection region, wherein said first edge regions of said plurality of ribbons are positioned proximate said second edge regions of said plurality of ribbons, wherein a plurality of fluid flow modulating regions is formed between adjacent ribbons of said plurality of ribbons,
said distal ends of said plurality of ribbons being engaged to each other in a joined relationship, wherein fluid flow through said sheet member at said joined distal ends of said plurality of ribbons is restricted while said fluid flow is allowed to be transmitted through said fluid flow modulating regions when in an open position,
said sheet member being configured to transition from an expanded position when said proximal valve annulus engagement end of said sheet member is engaged to said valve annulus region of said cardiovascular structure and receives said fluid flow therein, and said fluid flow exhibits a first positive flow pressure of said plurality of positive flow pressures, to a collapsed position when said fluid flow exhibits a first negative flow pressure of said plurality of negative flow pressures,
said plurality of fluid flow modulating regions being configured to transition from said open position when said sheet member is in said expanded position, wherein said plurality of fluid flow modulating regions allow said fluid flow to be transmitted through said sheet member, to a closed position when said sheet member is in said collapsed position, wherein said plurality of fluid flow modulating regions restrict said fluid flow through said sheet member.

US Pat. No. 10,188,509

PROSTHETIC TISSUE VALVES

CORMATRIX CARDIOVASCULAR,...

1. A prosthetic valve for modulating fluid flow through a cardiovascular structure during cardiac cycles of a heart, said fluid flow exhibiting a plurality of positive and negative flow pressures during said cardiac cycles, said prosthetic valve comprising:a remodelable biological tissue structure comprising a conical shaped sheet member, said sheet member comprising an extracellular matrix (ECM) composition, said ECM composition comprising acellular ECM from a mammalian tissue source,
said sheet member further comprising an open proximal annulus engagement end configured to engage said cardiovascular structure and receive said fluid flow therein and a closed distal end,
said sheet member further comprising a plurality of linear interstices disposed between said sheet member open proximal annulus engagement end and said closed distal end, wherein said plurality of linear interstices do not extend to said closed distal end,
said sheet member being configured to transition from an expanded position when said proximal annulus engagement end of said sheet member is engaged to said cardiovascular structure and receives said fluid flow therein, and said fluid flow exhibits a first positive flow pressure of said plurality of positive flow pressures, to a collapsed position when said fluid flow exhibits a first negative flow pressure of said plurality of negative flow pressures,
said plurality of linear interstices being configured to transition from an open position, when said sheet member is in said expanded position, to a closed position, when said sheet member is in said collapsed position,
said closed distal end of said sheet member being configured to block said fluid flow therethrough when said plurality of linear interstices are in said open and closed positions, wherein when said plurality of linear interstices are in said open position, said plurality of linear interstices allow said fluid flow to be transmitted through said plurality of linear interstices and said sheet member, and wherein when said plurality of linear interstices are in said closed position, said plurality of linear interstices and said distal end of said sheet member jointly block said fluid flow through said sheet member,
said sheet member being further configured to remodel, and induce host cell and tissue proliferation, remodeling of damaged cardiovascular tissue and regeneration of new cardiovascular tissue and tissue structures with site-specific structural and functional properties, when said proximal annulus engagement end of said sheet member is engaged to said cardiovascular structure, wherein said proximal annulus engagement end of said sheet member is disposed proximate damaged tissue of said cardiovascular structure.

US Pat. No. 10,188,508

BIOENGINEERED VOCAL FOLD MUCOSA FOR FUNCTIONAL VOICE RESTORATION

Wisconsin Alumni Research...

1. An engineered vocal fold mucosa comprising:(a) an engineered non-vascularized lamina propria comprising a scaffold comprising polymerized collagen populated by a plurality of human vocal fold fibroblasts (VFFs); and
(b) an engineered stratified squamous epithelium in contact with the engineered non-vascularized lamina propria of (a), the stratified squamous epithelium comprising a plurality of human vocal fold epithelial cells (VFEs);
wherein the engineered vocal fold mucosa, when implanted into a larynx, exhibits vibratory function and acoustic output of a native human vocal fold mucosa.

US Pat. No. 10,188,507

INTRAOCULAR LENS INJECTION SYSTEM AND CONTROLLER FOR CONTROLLING INTRAOCULAR LENS INJECTION DEVICE

NIDEK CO., LTD., Gamagor...

1. An intraocular lens injection system comprising:a push-out member comprising a drive part, the push-out member configured to push out an intraocular lens by use of the drive part, wherein the intraocular lens comprises an optical part and a support part configured to support the optical part in a patient's eye;
an observation member configured to obtain an observed image of the intraocular lens which is configured to be pushed out by the push-out member; and
a controller that determines a drive parameter of the drive part based on the observed image,
wherein the controller is configured to determine the drive parameter according to at least a shape of the support part.

US Pat. No. 10,188,506

INTRAOCULAR LENS INSERTER

Alcon Pharmaceuticals, Lt...

1. An implant inserter comprising:a compressed gas storage portion comprising a compressed gas cartridge configured to release a compressed gas into the compressed gas storage portion;
a hydraulic portion containing a substantially incompressible fluid;
a piston disposed between the compressed gas cartridge and the hydraulic portion and configured to impart pressure of the released compressed gas in the compressed gas storage portion to the substantially incompressible fluid in the hydraulic portion;
an actuator portion comprising a button or lever and a plunger mounted for sliding movement between a retracted position and an extended position, the actuator portion configured to allow a user to control a flow of the substantially incompressible fluid through the hydraulic portion to move the plunger from the retracted position to the extended position by using the button or lever; and
an implant retaining portion comprising an implant for insertion into a treatment region of an animal and aligned with the plunger such that the plunger pushes the implant when the plunger moves from the retracted position toward the extended position.

US Pat. No. 10,188,505

MATERIALS AND METHODS FOR IMPROVED BONE TENDON BONE TRANSPLANTATION

RTI Surgical, Inc., Alac...

1. A method of conducting orthopedic surgery on a recipient comprising:before the surgery, obtaining a bone/tendon allograft comprising (a) a first human bone block said first human bone block pre-shaped before surgery as a first pre-shaped dowel bone block having a dowel diameter specially adapted for fixation in a bone tunnel having a tunnel diameter for which the dowel is adapted, and (b) a tendon attached to said first human bone block via a naturally occurring attachment;
during the surgery, implanting the first human bone block in said bone tunnel having a diameter for which the first pre-shaped dowel bone block is adapted.

US Pat. No. 10,188,504

WHIPSTITCHED GRAFT CONSTRUCT AND METHOD OF MAKING THE SAME

ARTHREX, INC., Naples, F...

1. A method of forming a graft, comprising:forming a stitched region in a tendon strand by threading a suture loop/needle construct through the tendon strand and advancing the suture loop/needle construct in a direction toward an end of the tendon strand, wherein the suture loop/needle construct includes a continuous suture loop attached to a needle.

US Pat. No. 10,188,503

PROSTHESIS HAVING PIVOTING FENESTRATION

Cook Medical Technologies...

1. A prosthesis, comprising:a graft having a tubular body and a surface comprising a first biocompatible material;
at least one pivoting fenestration having a diameter extending from a sidewall of the graft;
a first perimeter having a first diameter and surrounding the at least one pivoting fenestration;
a band of flexible material surrounding the first perimeter and having a flexible frame;
a second perimeter in the side wall surrounding the band of flexible material and having a second diameter greater than the first perimeter diameter;
a first non-pivoting fenestration having a diameter disposed in the side wall of the graft; and
a second non-pivoting fenestration having a diameter disposed in the side wall of the graft,
where the band of material has a first diameter substantially the same as the first perimeter diameter and a second diameter substantially the same as the diameter of the second perimeter, and where the diameter of the band of material decreases in a direction away from the surface of the graft from the second perimeter to the first perimeter;
where the at least one pivoting fenestration is pivotable in any direction away from an axis perpendicular to a longitudinal axis of the prosthesis,
where at least one of the first non-pivoting fenestration and the second non-pivoting fenestration has a scallop configuration.

US Pat. No. 10,188,502

AORTIC GRAFT DEVICE

Cook Medical Technologies...

1. A prosthesis comprising:a unitary tube of graft material, the unitary tube of graft material comprising:
a stented graft portion having an outer perimeter, an inner lumen, a first end, a second end,
a completely unstented crimped portion integrally formed with and extending from the first end of the stented graft portion to form a junction between the unstented crimped portion and the first end of stented graft portion, the unstented crimped portion having an outer perimeter, and the junction having a circumference,
a plurality of independent ring stents extending from the junction to the second end of the stented graft portion including a first stent ring and a series of undulating ring stents extending distally from the first ring stent to the distal end of the stented graft portion,
a collar substantially at the junction between the first end of the stented graft portion and the unstented crimped portion and extending about the circumference of the junction,
at least one fenestration in the tube of graft material, and
a branch extending from the at least one fenestration in the tube of graft material,
wherein the first ring stent of the plurality of ring stents is disposed directly adjacent to the collar,
wherein the collar extends radially away from and beyond the entire outer perimeters of both the stented graft portion and the unstented crimped portion, such that the collar is configured to provide an extended stable surface structure away from the outer perimeters of the stented graft portion and the unstented crimped portion for the passage of sutures without the passage of sutures into the lumens of either the stented graft portion or the unstented crimped portion.

US Pat. No. 10,188,501

FORK-TYPE COVERED STENT

Lifetech Scientific (Shen...

1. A bifurcated stent graft, comprising:a body;
a side branch that forms an acute angle with the body, the side branch comprising a covering film and a first bare stent disposed only on the covering film, with a part of the first bare stent positioned adjacent a boundary line of the body and the covering film, and is located in a vertex angle area of the acute angle; and
wherein the first bare stent comprises at least one metal ring that defines different waveforms that include struts and a plurality of proximal vertices and a plurality of distal vertices, each strut having a proximal vertex and a distal vertex at opposite ends thereof, with an axial distance defined for the strut between each connecting proximal vertex and distal vertex, and wherein the axial distances are different along the at least one metal ring, with the strut closest to the acute angle having the shortest axial distance, and the strut furthest from the acute angle having the longest axial distance.

US Pat. No. 10,188,500

STENT GRAFT WITH EXTERNAL SCAFFOLDING AND METHOD

Medtronic Vascular, Inc.,...

1. A scaffolded stent-graft comprising:a hydrophobic graft material comprising an inner surface and an outer surface, the inner surface defining a lumen within the graft material, the graft material being hostile to tissue ingrowth therein; and
a scaffold comprising a metallic material mesh comprising openings therein coupled to the graft material at the outer surface, the scaffold configured to promote tissue ingrowth therein, the scaffold comprising a metal to artery ratio optimized to create stasis of blood within the scaffold resulting in thrombus formation, wherein the mesh is in the shape of a torus.

US Pat. No. 10,188,499

ARTIFICIAL VASCULAR GRAFT

1. An artificial vascular graft (1) comprising:a primary scaffold structure (2) encompassing an inner space (8) of the artificial vascular graft (1), said primary scaffold structure (2) having
a. an inner surface (21) facing towards said inner space (8) and
b. an outer surface (20) facing away from said inner space (8); and
a coating (3) on said inner surface (21) and on said outer surface (20)
characterized in that:
a plurality of grooves (4) is comprised in said coating (3) of said inner surface (21), wherein the grooves extend in a longitudinal direction of said coating (3) and
said primary scaffold structure (2) and said coating (3) on said inner surface (21) and on said outer surface (20) are designed in such a way that progenitor cells can migrate through an outer surface of said coating (3), said primary scaffold structure (2) and said inner surface of said coating (3) to said inner space (8); and
the primary scaffold structure (2) comprises a shape memory alloy.

US Pat. No. 10,188,498

EMBOLUS BLOOD CLOT FILTER DELIVERY SYSTEM

C. R. BARD, INC., Murray...

1. A blood filter delivery apparatus for delivery to a blood vessel having a vessel wall comprising:a) a catheter having a free end portion with a catheter opening and a catheter lumen that communicates with said catheter opening;
b) a filter and positioning assembly positioned within the catheter in a storage position wherein said assembly comprises an assembly member and a filter having a head and multiple filter leg members connected to the head;
c) a pusher that engages the assembly inside the catheter lumen, wherein the assembly member has an assembly member distal end adapted to engage one or more said filter leg members and a proximal end disposed within the catheter to define a stored position;
d) wherein the filter is positioned in between the catheter opening and the positioning assembly in said storage position; and
e) wherein the positioning assembly and filter are movable between said storage position within the catheter lumen and a preliminary dispensed position wherein said head is positioned distally of the filter legs and the catheter and at least some of the filter leg members are configured to engage the vessel wall while at least a portion of some of the filter leg members remain inside the catheter lumen.

US Pat. No. 10,188,497

IMPLANT CONVEYING DEVICE AND IMPLANTED MEDICAL INSTRUMENT

Lifetech Scientific (Shen...

1. An assembly, comprising:an implant for occluding a defect, the implant having a meshed body defining a through hole; and
an implant conveying device for delivering the implant to a treatment location, wherein the conveying device comprises a pusher, a control component, a connecting wire and a control wire;
the pusher, of which one end is connected to the control component, comprising a tube cavity and a lock hole communicated with the tube cavity;
one end of the control wire is connected to the control component, and the other end thereof is capable of being driven by the control component to be movably accommodated in the tube cavity of the pusher;
one end of the connecting wire is connected to the pusher or to the control component, and the other end thereof has a ring that extends through the through hole of the meshed body of the implant and then entering the lock hole; and
the control wire is capable of being driven by the control component to pass through the ring of the connecting wire to connect the implant with the conveying device, and the control wire is also capable of being driven by the control component to be disengaged from the ring of the connecting wire to release the implant so as to deliver the implant to the treatment location, wherein the conveying device is separated from the implant after the control wire is disengaged from the ring and the connecting wire is removed from the treatment location.

US Pat. No. 10,188,496

VENA CAVA FILTER FORMED FROM A SHEET

C. R. BARD, INC., Murray...

1. A blood filter for use in a patient's blood vessel having a vessel wall surrounding a vessel lumen, comprising:a) a longitudinally extending filter body including a proximal section extending a first fixed distance from a proximal terminal end of the longitudinal filter body to a first intermediate endpoint, said proximal section having a first cross-sectional area;
b) a distal section having a distal terminal end and a second cross-sectional area;
c) a joining section positioned between the proximal and distal sections and having a third cross-sectional area less than both the first and second cross-sectional areas;
d) said joining section spaced away from each of said terminal ends and extending a fixed second distance;
e) a first hub on said joining section that is slidable a fixed distance along a length of said joining section and in between said proximal and distal sections while in use in the blood vessel;
f) a plurality of appendages, each attached to said hub at an inner appendage end portion, each appendage having an outer appendage end portion providing unattached distal-most ends extending radially outward of said hub;
g) wherein said appendages are bendable in both a proximal and distal direction, thus enabling insertion of said filter body with hub and appendages using either a jugular access site or a femoral access site; and
h) wherein said filter body, said hub and said appendages are configured to occupy a vessel of a patient.

US Pat. No. 10,188,495

POSITIONING AGENT AND METHOD OF USING THE SAME

ATRIUM MEDICAL CORPORATIO...

1. A method of implanting a surgical mesh prosthesis, comprising the steps of:positioning a surgical mesh prosthesis against a surface of a target tissue with a positioning agent disposed between the surgical mesh prosthesis and the surface of the target tissue, wherein the positioning agent has an adhesion strength adequate to maintain the surgical mesh prosthesis temporarily in place, otherwise unsupported, against the target tissue in the absence of setting or curing of the positioning agent; and
adhering the surgical mesh prosthesis against the surface of the target tissue by the adhesion strength of the positioning agent;
wherein the positioning agent has a dynamic viscosity that comprises a first viscosity, when tested at 0.1 S?1 and 23° C., between about 150 Cps and 26,000,000 Cps, and a second viscosity, when tested at 9.77 S?1 and 23° C., that is between about 50 Cps and 2,530,000 Cps; and
wherein the positioning agent is a solution, gel or paste that includes water and one or more components selected from the group consisting of glycerin, sodium carboxymethylcellulose, maltrodextrin, hypromellose, carbopol resin, aloe vera, collagen and xantham gum.

US Pat. No. 10,188,494

METHODS OF USING DELIVERY SYSTEMS FOR THE PLACEMENT OF SURGICAL IMPLANTS

Ethicon, Inc., Somervill...

5. A method of inserting an implant into tissue comprising:providing an implant including an end and an insertion aid connected with said end of said implant;
providing an insertion device including a handle, an actuator, an elongated shaft, and a cutting element adjacent a distal end of said elongated shaft that is coupled with said actuator, wherein said elongated shaft includes an outer wall having an opening and said cutting element is disposed within said elongated shaft adjacent the opening in said outer wall;
providing an actuating wire that is disposed within said elongated shaft;
connecting a proximal end of said actuating wire with said actuator;
connecting a distal end of said actuating wire with said cutting element;
receiving said insertion aid in the opening in said outer wall of said elongated shaft;
engaging said actuator for moving said cutting element from a first position to a second position for breaking a connection between said insertion aid and said implant, the engaging step including pushing said actuator toward the distal end of said elongated shaft for moving said cutting element from the first position to the second position.

US Pat. No. 10,188,493

SURGICAL MESH WITH DIMENSIONALLY STABILIZED PORE

Atex Technologies, Inc., ...

1. A method of stabilizing a pore within a mesh fabric comprising the steps of:providing a mesh knit fabric made of a plurality of thermoplastic polymer yarns, the fabric having a first pore, the first pore having a first perimeter;
providing a frame comprising pins;
placing at least a portion of the fabric surrounding the first pore over the pins of the frame, whereby the portion of the fabric is temporarily held taut to define a taut fabric portion;
providing a support having an outer perimeter comprising a shape and having a tapered section;
inserting the support into the first pore so that the first pore perimeter is in contact with the outer perimeter of the support; and
placing the taut fabric portion and the support in an oven for a predetermined time at a predetermined temperature, whereby the first pore perimeter assumes the shape of the outer perimeter of the support.

US Pat. No. 10,188,491

DENTAL RESTORATION PRODUCING SYSTEM FOR PRODUCING DENTAL RESTORATION FROM DENTAL MILL BLANK WITH THROUGH-HOLE, OPERATION SYSTEM OF THE SYSTEM, PROGRAM FOR THE SYSTEM, AND DENTAL MILL BLANK FOR USE IN THE SYSTEM

SHOFU INC., Kyoto (JP)

1. A dental restoration producing system of producing a dental restoration from a dental mill blank with one or more through-holes, comprising;a data taking-in section taking in a dental mill blank shape data which indicates a shape of a dental mill blank and includes a position data of one or more through-holes, and a dental restoration shape data which indicates a shape of a dental restoration to be produced,
a superposed data generating section generating a superposed data in which the dental restoration is superposed in the dental mill blank based on the dental mill blank shape data and the dental restoration shape data, and
a control section controlling cutting of the dental mill blank based on the superposed data, wherein,
when the dental restoration includes no through-hole of the dental restoration, the superposed data generating section generates a superposed data in which at least one through-hole among the one or more through-holes of the dental mill blank is not superposed with the dental restoration,
when the dental restoration includes a through-hole of the dental restoration, the superposed data generating section generates a superposed data in which at least one through-hole among the one or more through-holes of the dental mill blank is not superposed with the dental restoration and the through-hole of the dental restoration, or a superposed data in which at least one through-hole among the one or more through-holes of the dental mill blank is included in the through-hole of the dental restoration which is larger than the at least one through-hole among the one or more through-holes of the dental mill blank, and
the control section controls cutting so that cutting is started from the at least one through-hole among the one or more through-holes of the dental mill blank.

US Pat. No. 10,188,490

METHODS AND SYSTEMS FOR DENTAL PROCEDURES

Align Technology, Inc., ...

1. A method for digitally aligning a patient's teeth with a reference portion of the patient, the method comprising:acquiring, using a scanner, a first image of at least a portion of the patient's teeth;
positioning a device in a patient's mouth to align the device with a reference portion of the patient, the device comprising an occlusal portion and a non-occlusal portion, the occlusal portion comprising a bite plate held between the patient's teeth so as to secure the device in a position during a scanning procedure and the non-occlusal portion comprising a coded pattern for aligning scanned images of the patient, the occlusal portion and the non-occlusal portion being coupled together at an angle such that the coded pattern is outwardly oriented from the patient's mouth when the bite plate is positioned between the patient's teeth, so that the coded pattern is presented to permit scanning of the coded pattern simultaneously when scanning at least the portion of the patient's teeth;
acquiring, using the scanner, a second image of at least a portion of the coded pattern and at least the portion of the patient's teeth: and
processing the first image and the second image to determine a spatial relationship between at least the portion of the patient's teeth and the reference portion by calculating a first spatial relationship between at least the portion of the coded pattern and at least the portion of the patient's teeth and the alignment between the device and the reference portion.

US Pat. No. 10,188,489

SINUS IMPLANT

Star Generation Limited T...

1. A sinus implant, comprising:an implant body having a mounting hole axially defined there through;
a plurality of positioning threads that are provided in a periphery of the implant body, that extend spirally upwardly around the periphery of the implant body, and that have a width that gradually decreases in a direction from a bottom end of the implant body toward an opposing top end of the implant body;
a pushing portion that protrudes from a top end of the sinus implant, that has a diameter that is reduced compared to that of the implant body, and that comprises a flat end face having defined therein a recess space and that includes an outer guide edge that is a smoothly arched and extends around a border of the flat end face, and an inner guide edge that is a smoothly arched and extends around the recess space within the flat end face, wherein, the pushing portion has a periphery that is without the plurality of positioning threads; and
at least one spiral groove that extends around the periphery of the implant body across the plurality of positioning threads, that reaches the periphery of the pushing portion, and that intersects with and communicates with the recess space.

US Pat. No. 10,188,487

DENTAL IMPLANT SUPERSTRUCTURE SUPPORT

1. A superstructure support (20) for disposition as part of a prosthetic tooth replacement (1) between an implantation body (10) and a superstructure consisting of an artificial crown (120) or a composite of a cement body (100) and the crown (120), the superstructure support (20) comprising:a screw insertion opening (61) including three zones extending through from a top surface to a bottom surface of the superstructure support (20);
an upper zone (67) having a cylindrical bore with a centerline (69) proximate to the top surface;
a lower zone (62) having a cylindrical bore with a centerline (63) proximate to the bottom surface;
an intermediate transition zone (64) positioned between the lower and upper zones having an internal conical area (65) coaxial with the centerline (63);
an outer area (51) adjacent the implantation body (10) having an implantation neck (52) including outer cone (53) above which an implant plate (31) is arranged;
a crown-supporting area (21) provided with an engagement structure (41) and an implantation post (23) which includes a screw seating bore (62);
a smooth microstructure surface (71) with an average arithmetic roughness value of 1.5 to 3.0 ?m provided with webs or grooves (74) at least partially extending around the superstructure support (20); and
spaced edges acting as bacteria barriers formed between a plurality of adjacent conical areas arranged on top of one another provided at the bottom side (32) of the implantation plate (31) on top of the implantation neck (52),
wherein an angle in the range of 155 to 178 angular degrees is formed between the centerline (69) of the upper zone and the centerline (63) of the lower zone.

US Pat. No. 10,188,485

DENTAL APPLIANCE DETACHABLY ATTACHED TO THE TEETH, AND FABRICATING METHOD THEREFOR

UNIVERSITY-INDUSTRY COOPE...

1. A dental appliance with an arch shape detachably attached to upper teeth or lower teeth forming a dental arch, comprising:a cover frame formed with a teeth recess extending in a longitudinal direction of the cover frame, the cover frame being a laminar structure including a first cover layer of a hard material and a second cover layer of a soft material provided at an inside relative to the first cover layer; and
a core frame of a hard material provided in the teeth recess of the cover frame and having a teeth-contacting surface shaped with impressions of end portions of teeth to which the dental appliance is attached,
wherein the cover frame includes a cover inner wall forming a wall on one side of the teeth recess so as to be provided on a lingual side of the teeth, a cover outer wall forming a wall on other side of the teeth recess so as to be provided on a front side of the teeth, and a cover base connecting the cover inner wall and the cover outer wall so as to cover the end portions of the teeth,
wherein the cover inner wall directly contacts lingual surfaces of the teeth, and the cover outer wall directly contacts front surfaces of the teeth,
wherein a left posterior teeth-contacting surface is shaped with impressions of end portions of at least one of posterior teeth at a left side of the dental arch and is formed on an inner surface of the cover base of the cover frame so as to directly contact the at least one of the posterior teeth at the left side to be occluded, and
a right posterior teeth-contacting surface is shaped with impressions of end portions of at least one of posterior teeth at a right side of the dental arch and is formed on the inner surface of the cover base of the cover frame so as to directly contact the at least one of the posterior teeth at the right side to be occluded, and
wherein the left posterior teeth-contacting surface is disposed between a left side end of the cover frame and a left side end of the core frame, and the right posterior teeth-contacting surface is disposed between a right side end of the cover frame and a right side end of the core frame.

US Pat. No. 10,188,484

SYSTEM OF COMPONENTS OR IMPLEMENTS FOR EASILY AND PRECISELY INSTALLING A DENTAL IMPLANT, AND A METHOD OF INSTALLING THE DENTAL IMPLANT

1. A system for implementing the installation of a winged dental implant within a blind bore implantation site defined within a patient's jaw, comprising:a rotary cutter assembly comprising a rotary cutting disk mounted upon a support post; and
a rotary cutter guide to be disposed within the blind bore implantation site defined within the patient's jaw, wherein said rotary cutter guide comprises a base portion and an upstanding body portion, a first vertically extending through-slot defined within said upstanding body portion of said rotary cutter guide such that said first vertically extending through-slot extends through said rotary cutter guide along a first plane from a first wall portion of said upstanding body portion to a second oppositely disposed wall portion of said upstanding body portion, and a second vertically extending through-slot defined within said rotary cutter guide such that said second vertically extending through-slot extends through said rotary cutter guide along a second plane which is disposed orthogonally with respect to said first plane such that said second slot extends from a third wall portion of said upstanding body portion to a fourth oppositely disposed wall portion of said upstanding body portion,
wherein said support post of said rotary cutter assembly extends through said first vertically extending through-slot defined within said upstanding body portion of said rotary cutter guider while oppositely disposed stub portions of said support post extend outwardly from said oppositely disposed first and second wall portions of said first vertically extending through-slot defined within said upstanding body portion of said rotary cutter guide so as to stably support said rotary cutter assembly within said rotary cutter guide, and opposite sides of said rotary cutting disk project outwardly from said oppositely disposed third and fourth wall portions of said second vertically extending through-slot defined within said upstanding body portion of said rotary cutter guide so as to be capable of cutting oppositely disposed slots within the patient's jaw for accommodating oppositely disposed wing members of the winged dental implant.

US Pat. No. 10,188,483

GASTRO-INTESTINAL SCOPE STERILIZATION, DISINFECTION AND STORAGE DEVICE AND METHODS OF MAKING AND USING SAME

16. A method of constructing gastro-intestinal (GI) scope disinfection and sterilization device, comprising the steps of:providing a gastro-intestinal (GI) scope with an insertion tube having a first end and a second end, a control section such that the second end of the insertion tube is operatively connected to the control section, a universal cord having a first end and a second end such that the first end of the universal cord is operatively connected to the control section and the second end of the insertion tube is operatively connected to a suction connector, and
providing an ultraviolet (UV) light assembly, wherein the UV light assembly is further comprised of;
a power source,
a first electrical extension operatively connected to the power source,
a UV light box operatively connected to the first electrical extension, and
first and second UV light sources operatively connected to the UV light box, wherein each of the first and second UV light sources includes a first end and a second end, wherein the first UV light source is located within an interior of the insertion tube and the second UV light source is located within an interior of the universal cord in order to disinfect and sterilize an interior of the gastro-intestinal (GI) scope and wherein each of the first and second UV light sources is further comprised of a UV light having a tube and a plurality of UV lights located on the tube.

US Pat. No. 10,188,481

BEAM GUIDE FOR OPHTHALMIC SURGICAL ILLUMINATION

Novartis AG, Basel (CH)

1. An ophthalmic illumination apparatus, comprising:a movable support;
an optical array coupled to the movable support and positioned to interact with a light beam from a light source, the optical array including first and second optical elements, wherein the first optical element is configured to reflect and transmit first associated amounts of the light beam, and wherein the second optical element is configured to reflect and transmit second associated amounts of the light beam different than the first optical element; and
a drive mechanism coupled to the movable support, wherein the drive mechanism is configured to cause the movable support to selectively move the optical array such that the light beam is selectively incident upon one of the first optical element or the second optical element.

US Pat. No. 10,188,480

SYSTEMS AND METHODS FOR PERFORMING SPINE SURGERY

NuVasive, Inc., San Dieg...

1. A system for global alignment of a spine during spinal surgery, the system comprising an imaging device, a spatial tracking system, a bending device, and, a control unit configured to:receive a planned target value of one or more spinal parameters;
based on the planned target value of the one or more spinal parameters, determine one or more ranges corresponding to a desired correction in at least one of (i) a sagittal alignment and (ii) a coronal alignment of the spine;
capture, via the imaging device and the spatial tracking system, one or more intraoperative fluoroscopy images;
measure an intraoperative value of the one or more spinal parameters according to the one or more captured intraoperative fluoroscopy images;
compare the intraoperative value of the one or more spinal parameters with the planned target value of the spinal parameters;
based on the comparison, determine that the intraoperative value of the one or more spinal parameters is within the one or more ranges and measure a location of one or more screws; and
calculate an instruction to bend a rod, via the bending device, to the location of the one or more screws.

US Pat. No. 10,188,479

CARRYING BAG

1. A negative pressure wound therapy kit comprising:a negative pressure wound therapy system comprising:
a housing enclosing a source of negative pressure configured to provide negative pressure wound therapy to a wound, the housing comprising a user interface positioned on an exterior of the housing; and
a canister configured to be attached to the housing and to be in fluidic communication with the source of negative pressure configured to provide negative pressure wound therapy to a wound negative pressure, the canister including a tubing configured to be fluidically connected to the wound; and
a carrying case comprising:
a pouch sized to enclose the housing and the canister of the negative pressure wound therapy system, the pouch having a window configured to permit viewing of the user interface, the pouch further comprising an opening sized to allow the housing and the canister to be placed into the pouch by being passed through the opening;
a fastener adapted to close at least a first portion of the opening while leaving a second portion of the opening open, the second portion of the opening being sized so that the tubing can pass through the second portion of the opening while the housing and the canister cannot pass through the second portion of the opening;
a pocket disposed on the carrying case and outside of the pouch, the pocket sized to enclose at least a portion of the tubing passed through the second portion of the opening, wherein the at least the portion of tubing comprises excess tubing in use; and
first and second flaps configured to conceal the housing and the canister of the negative pressure wound therapy system, the first flap configured to cover at least the window in a first position and to permit viewing of the window in a second position.

US Pat. No. 10,188,478

DEVICE HOUSING PROTECTED AGAINST PENETRATION OF LIQUIDS

1. A device housing for devices with at least one module, which is to be protected against penetration of liquids, the device housing comprising:a housing with a top side opening having an edge area comprising at least one mounting groove, said housing comprising a first wall and a second wall, at least said first wall and said second wall defining said mounting groove, wherein at least one outlet is provided for each said mounting groove through which penetrated liquid is guided out of the housing;
a cover arranged on the top side of the housing closing the opening in a closed position, the cover having an outer edge area comprising a collar which protrudes downwards when the cover is in the closed position and having a drip edge arranged below the collar when the cover is in the closed position, such that a liquid dripping from the drip edge falls into the mounting groove, wherein the cover has another collar to provide two collars arranged at a distance to one another, each of said two collars protruding downwards into the mounting groove, said collar and said another collar being directly connected to the same cover, wherein at least a portion of each of said two collars is located between said first wall and said second wall.

US Pat. No. 10,188,477

MOBILE MEDICAL CART

Neonatal Product Group, I...

1. A medical cart for transporting medical supplies, the cart comprising:a chassis having a plurality of wheels attached thereto;
a plurality of drawers supported on the chassis, wherein
at least one of the drawers is slidable along a first axis toward the chassis to a closed orientation and slidable away from the chassis along the first axis to an open configuration, and
at least one of the drawers has a drawer lock shiftable between a locked position in which it secures the drawer in the closed orientation and an unlocked position in which it allows the drawer to be in the open configuration;
a temperature-regulated compartment having
a storage space with a door,
a lock shiftable between a locked position in which it prevents the door from opening and an unlocked position in which it allows the door to open, and
a temperature-regulating unit that regulates a temperature of the storage space at a predetermined temperature;
a locking bar pivotally attached to the chassis and shiftable between a locked position in which it prevents opening of the drawers and the door of the temperature-regulated compartment and an unlocked position in which it allows the drawers to open when the drawer locks are in their unlocked positions and allows the door to open when the door lock is in its unlocked position so that the locking bar serves as a secondary safety lock for all the drawers and the door of the temperature-regulated compartment;
a headwall mount attached to the chassis having a vertically-adjustable bar and a horizontal cross bar;
a display attached to the chassis; and
a positionable task light attached to the chassis having a deformable body portion, and a light source.

US Pat. No. 10,188,476

MEDICAL GOWN HAVING AN INTEGRAL PROTECTIVE SLEEVE FOR MEDICAL EQUIPMENT

1. A protective medical gown comprising:a gown body adapted to be worn by a medical professional, the gown body having a front panel section, the gown body oriented by an exterior surface and an interior surface when worn;
an orifice centrally located in a central region of a front portion of the gown body; and
a tubular protective sleeve joined to the gown body at an attachment end circumscribing the centrally located orifice, the tubular protective sleeve extending freely and outward from the gown body, the tubular protective sleeve having a shape and size to receive a distal portion of a medical device;
an interior pocket separate segment from the tubular protective sleeve assembled to the interior surface of the gown body, the interior pocket comprising a sheet of material joined to the interior surface of the gown body along each of a first edge of the interior pocket and a second edge of the interior pocket, the interior pocket located to support a proximal portion of the medical device, having a first end proximate the centrally located orifice and a second end proximate a neckline of the gown body,
wherein the gown body and tubular protective sleeve are fabricated of a material and assembled to one another creating an impervious barrier to biomedical hazardous materials.

US Pat. No. 10,188,475

DRAPE FOR EQUIPMENT HAVING CYLINDRICAL OR OTHER NON-PLANAR CONTOURS

Medline Industries, Inc.,...

1. A method of manufacturing a drape, comprising:configuring a sterile drape with accordion folds to form two abutting elongated accordion fold stacks linked by a bottom section;
wrapping the sterile drape with a drape wrapping layer to form a wrapped drape; and
folding the wrapped drape with one or more book folds to form a folded drape.

US Pat. No. 10,188,474

SKIN-TO-SKIN CONTACT OBSTETRICAL SURGICAL DRAPE

CLEVER MEDICAL, Sanford,...

1. A surgical fenestration drape for the Cesarean delivery of a newborn, the drape comprising:a drape sheet having a surgical opening and a portal, said sheet having a sterile field side and an opposite non-sterile-field side;
a first means secured to a portion of the non-sterile field side of the drape, the first means being configured for closing the portal, said first means configured to be selectively manipulated from the non-sterile field side; and
a second means secured to a portion of the sterile field side of the drape, the second means being configured for closing the portal, said second means configured to be selectively manipulated from the sterile-field side;
whereby, the portal is configured for closing by the first means until birth, when said first means is configured to be withdrawn from the portal while a portion of the first means remains attached to the non-sterile field side of the drape sheet to provide a window for the newborn to be placed into skin-to-skin contact with the mother's chest, and thereafter the second means is configured to close the portal, the sterile field side and a portion of the first means configured to maintain the integrity of the sterile-field throughout ensuing procedure.

US Pat. No. 10,188,473

WIRE DRIVING DEVICE AND MANIPULATOR

OLYMPUS CORPORATION, Tok...

1. A wire driving device comprising:a pair of wires, one end of each individual wire in the pair of wires being attached to a movable member for antagonistically driving the movable member;
a pair of pulleys, an other end of each individual wire in the pair of wires being secured to an individual pulley in the pair of pulleys, each individual wire being wound around a respective one of each individual pulley;
a pair of driven gears, each driven gear in the pair of driven gears being coaxially secured to a respective one of each individual pulley;
a drive gear that is connected to a driving source that generates motive power; and
a pair of movable gears, each individual movable gear of the pair of movable gears being disposed between the drive gear and a respective one of each individual driven gear, each individual movable gear transmitting the motive power of the driving source to the respective driven gear from the drive gear,
wherein each individual movable gear is provided in a movable manner so that the pair of movable gears engage with the drive gear and with each respective individual driven gear when the drive gear is rotated in a manner in which the pair of pulleys wind a respective wire, and so that engagement of one individual movable gear with at least one of the drive gear and a respective individual driven gear is released when the drive gear is rotated in a manner in which a respective pulley unwinds a respective wire.

US Pat. No. 10,188,472

MEDICAL ROBOTIC SYSTEM WITH COUPLED CONTROL MODES

Intuitive Surgical Operat...

1. A system comprising:an imaging system having a field of view;
a slave manipulator adapted to manipulate a device when the device is coupled to the slave manipulator; and
a device controller automatically commanding the slave manipulator to move a working end of the device until the working end is within the field of view of the imaging system, after receiving an indication to do so.

US Pat. No. 10,188,471

TELE-OPERATIVE SURGICAL SYSTEMS AND METHODS OF CONTROL AT JOINT LIMITS USING INVERSE KINEMATICS

INTUITIVE SURGICAL OPERAT...

1. A tele-operation control method comprising:receiving a first manipulation command to move a distal end effector of a manipulator arm to a desired first position within a workspace, the manipulator arm extending between a proximal base and the distal end effector;
calculating a joint movement of one or more joints of a master control corresponding to calculated movement of a plurality of joints of the manipulator arm using inverse kinematics of the manipulator arm; and
when a first joint of the plurality of joints is at a joint range-of-motion (ROM) limit of the first joint, modifying an input variable within the inverse kinematics of the manipulator arm to lock the first joint, wherein the input variable corresponds to movement of the first joint within the workspace so that the calculated joint movement of the one or more joints of the master control provides improved force feedback.

US Pat. No. 10,188,470

MINIMALLY INVASIVE SURGICAL INSTRUMENT TO PROVIDE NEEDLE-BASED THERAPY

INTUITIVE SURGICAL OPERAT...

1. A minimally invasive surgical instrument, comprising:a first input mechanism comprising a periphery and an axial slot in the periphery, wherein a first axial axis of rotation is defined for the first input mechanism;
a second input mechanism comprising a surface and a helical slot in the surface, wherein a second axial axis of rotation is defined for the second input mechanism, and wherein the second input mechanism surrounds the first input mechanism such that the second axial axis of rotation is coincident with the first axial axis of rotation;
an insert comprising a pin, wherein a third axial axis of rotation is defined for the insert, wherein the insert is surrounded by the first input mechanism such that the third axial axis of rotation is coincident with the first axial axis of rotation, and wherein the pin extends from the insert through the axial slot of the first input mechanism and into the helical slot of the second input mechanism; and
a needle coupled to an end of the first input mechanism.

US Pat. No. 10,188,469

INSTRUMENT, MANIPULATOR SYSTEM, AND CONTROL METHOD OF INSTRUMENT

OLYMPUS CORPORATION, Tok...

1. A manipulator system comprising:a medical instrument configured to be inserted into a body;
a manipulator configured to hold a portion of the instrument positioned in the body;
a switch configured to detect whether or not the manipulator holds the portion of the instrument positioned in the body;
an instruction-receiving part configured to detect an instruction for operating the instrument; and
a controller comprising hardware, the controller being configured to operate the instrument based on the instruction from the instruction-receiving part only when the switch detects that the manipulator holds the portion of the instrument positioned in the body,
wherein the switch detects whether or not the manipulator holds the portion of the instrument positioned in the body according to a conduction state and a cutoff state between a pair of contacts,
the switch switches the conduction state and the cutoff state between the pair of contacts by being pressed in a reference direction,
the manipulator has a gripper that grips the switch in the reference direction,
the instrument comprises a first instrument and a second instrument, and the controller is configured to:
operate only the first instrument where the instruction-receiving part detects the instruction when the switch detects whether or not the manipulator holds a portion of the first instrument positioned in the body, and
operate only the second instrument where the instruction-receiving part detects the instruction when the switch detects whether or not the manipulator holds a portion of the second instrument positioned in the body.

US Pat. No. 10,188,468

FOCUSED BASED DEPTH MAP ACQUISITION

SYNAPTIVE MEDICAL (BARBAD...

1. A medical navigation system for acquiring a depth map of a surgical site of interest in a patient, comprising:a camera for viewing the surgical site of interest and having a depth of field and an adjustable focus,
a light projecting device for projecting an edge indicator on the surgical site of interest;
a display; and
a controller electrically coupled to the camera, the light projecting device, and the display, the controller having a processor coupled to a memory, the controller configured to:
generate a signal provided to the light projecting device to project the edge indicator on the surgical site of interest;
generate a signal to operate the camera to perform a focus sweep and capture a plurality of images during the focus sweep such that substantially all elements of the surgical site of interest are in focus in at least one of the plurality of images, the plurality of images including the projected edge indicator;
receive from the camera data representing the plurality of images captured during the focus sweep;
generate a depth map of the surgical site of interest using the data representing the plurality of images;
generate a signal to operate the camera to capture a live video feed of the surgical site of interest while a surgical procedure is being performed;
receive from the camera data representing the live video feed;
cause the display to display the live video feed; and
cause the display to display the depth map, the depth map being overlaid on the live video feed, the depth map including a series of contour lines.

US Pat. No. 10,188,467

SURGICAL GUIDANCE INTERSECTION DISPLAY

InnerOptic Technology, In...

1. A method, comprising:receiving first emplacement data associated with a first device tracker associated with a first medical device;
receiving second emplacement data associated with a second device tracker associated with a second medical device;
determining emplacement of a virtual 3D rendering of the first medical device with respect to a point-of-view location based at least in part on the first emplacement data;
determining emplacement of an image region with respect to the point-of-view location based at least in part on the second emplacement data;
determining an intersection of an axis associated with the virtual 3D rendering of the first medical device and at least a portion of the image region based at least in part on the determined emplacement of the virtual 3D rendering of the first medical device and the determined emplacement of the image region;
determining an intersection indicator based at least in part on the determined intersection, a variance parameter of the first device tracker, and an orientation angle of the virtual 3D rendering of the first medical device with respect to the image region; and
causing one or more displays to concurrently display:
a perspective view of at least a portion of the virtual 3D rendering of the first medical device in a virtual 3D space based at least in part on the determined emplacement of the virtual 3D rendering of the first medical device,
a perspective view of at least a portion of the image region based at least in part on the determined emplacement of the image region, and
the intersection indicator, wherein an area of the intersection indicator increases in proportion to a decrease in the orientation angle.

US Pat. No. 10,188,466

METHODS AND SYSTEMS FOR DIRECTING MOVEMENT OF A TOOL IN HAIR TRANSPLANTATION PROCEDURES

RESTORATION ROBOTICS, INC...

1. A method of selecting a follicular unit harvesting or implanting site, the method comprising:processing at least one image of a body surface containing follicular units, using at least one processing unit, to identify multiple rows;
determining, using the at least one processing unit or at least one different processing unit, whether a number of harvested or implanted follicular units in a first row is within a range of a desired number of harvested or implanted follicular units for the first row;
automatically suggesting a direction of movement of a tool for harvesting or implantation follicular units based on the results of the determining step as follows:
a) if the number of harvested or implanted follicular units in the first row is within the range of the desired number of harvested or implanted follicular units for the first row, indicating movement of the tool to a subsequent row; and
b) if the number of harvested or implanted follicular units in the first row is less than a lower threshold value of the range of the desired number of harvested or implanted follicular units for the first row, indicating continuance of harvesting or implanting the at least one additional follicular unit in the first row.

US Pat. No. 10,188,465

AUTOMATIC ENT SURGERY PREPLANNING USING A BACKTRACKING MAZE PROBLEM SOLUTION

Biosense Webster (Israel)...

1. A method, comprising:(a) receiving a computerized tomography (CT) scan of at least a part of a body of a patient;
(b) identifying voxels of the scan that correspond to regions in the body;
(c) displaying the scan on a screen and marking thereon selected start and termination points for a probe inserted in the body;
(d) finding a path from the start point to the termination point comprising a connected set of the identified voxels that are traversable by the probe, wherein finding the path comprises determining a set of density data associated with each of the identified voxels, determining a traversable density range, and determining the connected set of the identified voxels based at least upon the set of density data associated with those voxels being within the traversable density range;
(e) using the scan to generate a representation of an external surface of the body and displaying the representation on the screen;
(f) selecting a first region of the representation of the external surface to be transparent, wherein the first region is associated with the path such that the path is viewable through the first region;
(g) selecting a second region of the representation of the external surface to be non-transparent;
(h) rendering the first region transparent in the displayed representation, so as to make visible on the screen an internal structure of the body in a vicinity of the path; and
(i) rendering the second region non-transparent while rendering the first region transparent;
wherein the traversable density range comprises at least one density other than the density of air.

US Pat. No. 10,188,464

SENSOR-BASED SHOULDER SYSTEM AND METHOD

Zimmer, Inc., Warsaw, IN...

1. Method for providing graphical feedback visualizing forces within a joint through a range of motion of the joint, the method comprising:receiving, using one or more processors, position data for at least one bone of the joint while the at least one bone is moved through a range of motion (ROM);
concurrently to receiving the position data, receiving, using one or more processors, force data from at least one force sensor embedded within a trial prosthesis in the joint;
generating, for display on a display device, a graphical representation based on the position data and the force data, the graphical representation illustrating changes in the force data versus locations of the bone as it moved through the ROM; and
comparing the graphical representation with pre-generated target graphical presentation to determine whether the trial prosthesis provides target joint tension throughout the range of motion.

US Pat. No. 10,188,463

BONE LENGTH DETERMINATION

Stryker European Holdings...

1. A method for measuring an actual length of a fractured bone, wherein an implant is already introduced into the fractured bone, wherein a first reference body and a second reference body are already arranged in a predetermined relation to the implant, the method comprising the steps of:receiving a first 2D fluoroscopic image including the first reference body and a first bone feature;
determining a first spatial relation between the first reference body and a first end point at the first bone feature;
receiving a second 2D fluoroscopic image including the second reference body and a second bone feature;
determining a second spatial relation between the second reference body and a second point (P) at the second bone feature;
receiving data of a bone model having corresponding first and second bone features, determining a third spatial relation between the second point (P) of the second bone feature and a second end point (EP1) at the bone model; and
determining the actual length of the fractured bone based on the first, second, and third spatial relation, and on the predetermined relation of the reference bodies to each other.

US Pat. No. 10,188,461

SELECTIVE FAT REMOVAL USING PHOTOTHERMAL HEATING

THE REGENTS OF THE UNIVER...

1. A method for selective removal of fat in a subject in need thereof, comprising:distributing photo-absorbing nanoparticles uniformly within a target area comprising adipose tissue located beneath a skin surface of the subject by injecting a solution comprising gold nanorods suspended in a biocompatible liquid at a concentration range of 1011 to 1013 GNR/mL; and
delivering a series of pulses of near infrared light across the skin surface and into the target area for an exposure duration to induce surface plasmon resonance in the nanoparticles, wherein the near infrared light has a combination of optical parameters selected from the group consisting of beam energy, pulse duration, emission wavelength within a range of 700 to 900 nm, emission intensity, beam focus and beam area, the optical parameters and the exposure duration selected to excite the nanoparticles to liquefy fat within the target area.

US Pat. No. 10,188,460

CHOKED DIELECTRIC LOADED TIP DIPOLE MICROWAVE ANTENNA

Covidien LP, Mansfield, ...

1. A microwave antenna assembly, comprising:a feedline including an inner conductor, an outer conductor and an inner insulator disposed therebetween;
a radiating section coupled to the feedline, the radiating section including:
a dipole antenna having a proximal portion and a distal portion and a feed point having a dielectric material therebetween; and
a tubular dielectric loading disposed about the dipole antenna, a dielectric permittivity of the tubular dielectric loading is higher than a dielectric permittivity of the dielectric material of the feed point; and
a choke disposed around at least a portion of the feedline, the choke including an inner dielectric layer and a tubular structure having an inner cylindrical casing and an outer cylindrical casing defining a cavity therebetween configured to supply a dielectric coolant to the radiating section, the inner dielectric layer extending distally past a distal end of the tubular structure.

US Pat. No. 10,188,459

ABLATION CATHETER WITH FLEXIBLE ELECTRODE

ST. JUDE MEDICAL, ATRIAL ...

1. An ablation catheter comprising a catheter body and a hollow elongate electrode disposed at a distal end of the catheter body, the electrode comprising an axial length and a sidewall provided with one or more elongate gaps extending therethrough, the one or more elongate gaps configured to provide flexibility in the sidewall and to allow shortening of the electrode axial length when a force is applied to the electrode in an axial direction.

US Pat. No. 10,188,458

INDUCTIVE DISTURBANCE REDUCTION DEVICE

Koninklijke Philips N.V.,...

1. An inductive disturbance reduction device for reducing an inductive disturbance of signals transmitted via first connection conductors of an electrical connector, the inductive disturbance being caused when radio frequency ablation current usable for ablating tissue flows through a second connection conductor of the electrical connector, wherein the electrical connector is adapted to electrically connect an ablation catheter with a radio frequency ablation current source, the inductive disturbance reduction device comprising:first compensation conductors adapted to be electrically connected to the first connection conductors of the electrical connector, the first compensation conductors of the inductive disturbance reduction device being adapted to transmit the signals, and
a second compensation conductor adapted to be electrically connected to the second connection conductor of the electrical connector, the second compensation conductor of the inductive disturbance reduction device being adapted to transmit the radio frequency ablation current, wherein:
the first compensation conductors and the second compensation conductor of the inductive disturbance reduction device are arranged such that a compensation voltage is induced in the first compensation conductors of the inductive disturbance reduction device when the radio frequency ablation current flows through the second compensation conductor of the inductive disturbance reduction device; and
the compensation voltage induced in the first compensation conductors of the inductive disturbance reduction device at least partly compensates a connection voltage, having a polarity opposite a polarity of the compensation voltage, induced in the first connection conductors of the electrical connector when the radio frequency ablation current flows through the second connection conductor of the electrical connector.

US Pat. No. 10,188,457

SELECTABLE ECCENTRIC REMODELING AND/OR ABLATION

Vessix Vascular, Inc., L...

1. An apparatus comprising:a catheter configured for intravascular placement within a blood vessel of a human patient;
an expandable balloon at a distal portion of the catheter, wherein the expandable balloon is configured to vary between a delivery configuration and a deployed configuration sized to fit within the blood vessel;
a first pair of bipolar contacts attached to the expandable balloon; and
a second pair of bipolar contacts attached to the expandable balloon,
wherein the first pair of bipolar contacts and the second pair of bipolar contacts are spaced apart lengthwise and angularly offset from one another when the expandable balloon is in the deployed configuration,
wherein each of the first pair of bipolar contacts and the second pair of bipolar contacts is configured to deliver thermal energy to less than a full circumference of the blood vessel of the patient.

US Pat. No. 10,188,456

ELECTRODE ASSEMBLY FOR RF ENERGY ENABLED TISSUE DEBRIDEMENT DEVICE

Medtronic Xomed, Inc., J...

1. A blade assembly extending from a proximal region to a distal region, comprising:an outer shaft assembly including an outer shaft defining a lumen extending along a central axis, an outer circumference, a proximal end and a distal end opposite the proximal end, wherein the distal end defines a cutting window in the outer shaft assembly and a first electrode surface;
an inner shaft assembly rotatably disposed within the lumen of the outer shaft assembly about the central axis, the inner shaft assembly defining a distal portion, the distal portion further including a cutting tip;
an electrode body extending along the outer circumference and electrically isolated from the outer shaft, the electrode body defining a U-shape in cross section with respect to a plane that is perpendicular to the central axis and a second electrode surface spaced apart from the first electrode surface;
a hub rotatably supporting the outer shaft and the electrode body, wherein upon rotation of the hub about the central axis, the outer shaft and the electrode body rotate about the central axis;
a rotary electrical connection assembly comprising an outer connector and an inner connector rotatably disposed within the outer connector, the inner connector electrically connected to the electrode body;
an irrigation channel fluidly coupled with the hub and configured to deliver fluid from the proximal region to the distal region; and
wherein each of the outer connector, the inner connector and the electrode body are formed of a conductive material and extend a respective length in a direction parallel to the central axis, and further wherein, when viewed in cross section along an entirety of the respective length and with respect to the plane that is perpendicular to the central axis, each define a maximum distance from the central axis that includes conductive material such that, for a circle having an origin at the central axis and a circumference at the maximum distance, there exists at least one sector of the circle free of conductive material.