US Pat. No. 10,478,229

PIVOTAL BONE ANCHOR ASSEMBLY WITH BOTTOM LOADED INSERT AND PIVOTLESS RETAINER

Roger P. Jackson, Prairi...

1. A pivotal bone anchor assembly for securing an elongate rod to a bone, the pivotal bone anchor assembly comprising:a shank having an upper capture portion and an anchor portion extending distally from the upper capture portion for fixation to the bone;
a receiver having a top, a bottom, and a longitudinal axis extending from the top to the bottom, a base defining a chamber communicating with the bottom of the receiver through a bottom opening, and a first pair of upstanding arms extending upwardly from the base to define a first channel opening onto the top of the receiver and configured to receive the elongate rod, the first channel communicating with the chamber, the chamber having an upper cylindrically shaped expansion portion with a first diameter and a lower cylindrically shaped locking portion with a second diameter smaller than the first diameter, the locking portion further defined in part by an upwardly-facing seating surface extending perpendicular to the longitudinal axis;
an insert having a second pair of upstanding arms defining a second channel opening onto a top of the insert and configured to receive the elongate rod, the insert being uploaded into the receiver chamber through the bottom opening, the insert having an outer surface that is slidably engageable with a longitudinal alignment structure formed in the receiver to prevent rotation between the insert and the receiver and to maintain the second channel in alignment with the first channel; and
an open retainer ring having a top surface, a bottom surface, an internal surface, and an external surface, and having a gap extending entirely through the ring from the top surface to the bottom surface and from the internal surface to the external surface, the retainer ring being uploaded into the receiver chamber through the bottom opening after the insert and positionable within the receiver chamber,
wherein the shank upper capture portion is uploadable into the receiver chamber through the bottom opening after the insert and the retainer ring, in which the upward loading motion of the shank upper capture portion along the longitudinal axis urges the retainer ring into expansion within the upper cylindrically shaped expansion portion, after which the retainer ring resiliently returns to a non-expanded state within the lower cylindrically shaped locking portion so as to capture the shank upper capture portion within the receiver chamber, and
wherein the insert is configured to engage the shank upper capture portion, with the retainer ring being seated against the upwardly-facing seating surface, so as to lock the shank with respect to the receiver.

US Pat. No. 10,478,227

ORTHOPEDIC FIXATION DEVICES AND METHODS OF INSTALLATION THEREOF

GLOBUS MEDICAL, INC., Au...

1. A modular tulip system for spine stabilization, said system comprising:a first tulip assembly comprising a first tulip element and a second tulip element separated from the first tulip element, wherein the first tulip element is configured to be received modularly over a first bone fastener, wherein the first tulip element comprises a first pair of arms defining a first channel and the second tulip element comprises a second pair of arms defining a second channel, wherein a bridge extends between the first pair of arms and the second pair of arms, wherein the first pair of arms and the second pair of arms are formed monolithically with the bridge;
a first locking cap assembly configured to be received in the first channel between the first pair of arms and a second locking cap assembly configured to be received in the second channel between the second pair of arms; and
a first rod member configured to be received in the first tulip assembly via the first tulip element,
wherein the first pair of arms and the second pair of arms are positioned in a vertical direction such that the first rod member can be downwardly deposited into the first pair of arms, and
wherein the first tulip element has an exposed opening for receiving a first bone fastener while the second tulip element of the first tulip assembly does not have an exposed opening for receiving a bone fastener.

US Pat. No. 10,478,225

TOOL COMPRESSED INSERT FOR CLOSURE INDEPENDENT LOCKING OF A PIVOTAL BONE ANCHOR ASSEMBLY

Roger P. Jackson, Prairi...

1. A pivotal bone anchor assembly for securing an elongate rod to a bone with a closure via closure independent locking with an insert compressing tool, the pivotal bone anchor assembly comprising:a receiver having a base defining a cavity communicating with a bottom opening, and a pair of upright arms extending upwardly from the base to define an open channel for receiving the elongate rod, the open channel communicating with the cavity to define a central bore, the pair of upright arms including:
opposed inward-facing surfaces having a discontinuous helically wound closure-mating structure formed therein; and
outward-facing surfaces having receiver tool engagement structures formed therein for releasable overlapping engagement with the insert compressing tool;
a bone anchor having a capture portion pivotally disposed within the receiver cavity and an anchor portion extending distally from the capture portion and through the receiver bottom opening for fixation to the bone; and
a compression insert at least partially disposed within the receiver center bore and having an upper surface configured for engagement with the elongate rod, the insert having a central opening and upward-facing surfaces on tool engagement structures positioned radially outward from the central opening,
wherein the the receiver tool engagement structures and the insert upward-facing tool engagement structures are configured for simultaneous non-threadable engagement and downward compressing engagement, respectively, by the insert compressing tool, thereby applying a downward force to independently lock a position of the bone anchor with respect to the receiver prior to securing the elongate rod within the receiver open channel via the closure, and
wherein the closure is positionable within the channel while the position of the bone anchor with respect to the receiver is so independently locked by the insert compressing tool.

US Pat. No. 10,478,222

METHOD OF SECURING PERIANAL SUPPORT DEVICE

Stetrix, Inc., Oakland, ...

1. A method of inhibiting perianal tissue distention of a patient during a child birthing process, comprising:providing a support member having an engagement surface configured for engaging perianal tissue of the patient as the patient pushes during at least a portion of the child birthing process;
positioning the engagement surface in a first supporting position in engagement with the perianal tissue of the patient prior to delivery of a child;
securing the support member in the first supporting position relative to the perianal tissue; and
maintaining the first supporting position of the support member on at least a portion of perianal tissue during at least one push of the child birthing process.

US Pat. No. 10,478,211

FEATURES TO PROMOTE REMOVAL OF DEBRIS FROM WITHIN ULTRASONIC SURGICAL INSTRUMENT

Ethicon LLC, Guaynabo, P...

1. An instrument, comprising:(a) an ultrasonic blade, wherein the ultrasonic blade defines a distal opening, wherein the ultrasonic blade is operable in a first mode to emulsify tissue that is distally positioned relative to the ultrasonic blade, wherein the ultrasonic blade is further operable in a second mode to transect and seal tissue that is transversely positioned relative to the ultrasonic blade;
(b) a first fluid port in fluid communication with the distal opening of the ultrasonic blade;
(c) an irrigation member having an irrigation opening positioned adjacent to a distal end of the ultrasonic blade;
(d) a second fluid port in fluid communication with the irrigation opening of the irrigation member; and
(e) a fluid communication assembly fluidly connected to the first and second fluid ports and having a fluid inlet port and a suction inlet port respectively configured to connect to a fluid source and a suction source, wherein the fluid communication assembly is configured to:
(i) couple the first fluid port with the fluid inlet port for distally directing a fluid from the fluid source from the first fluid port toward the distal opening,
(ii) couple the first fluid port with the suction inlet port for proximally directing a suction to the suction source from the distal opening toward the first fluid port, and
(iii) couple the second fluid port with the fluid inlet port for distally directing the fluid from the fluid source from the second fluid port toward the irrigation opening.

US Pat. No. 10,478,209

DEFLECTABLE SHAVER TOOL

BIOSENSE WEBSTER (ISRAEL)...

1. A surgical tool comprising:a blade comprising:
a rotatable cutting shaft comprising a distal cutting end and a proximal non-cutting end, and
an outer sheath coaxially surrounding the rotatable cutting shaft, including a cutting window at the distal cutting end, at least a portion of the outer sheath being deflectable;
an actuator coupled to a proximal end of the outer sheath and comprising:
a first slider surrounding a portion of the circumference of the outer sheath, and
a second slider surrounding an opposite portion of the circumference of the outer sheath:
a handpiece comprising a suction portion;
a first wire operatively coupled at its proximal end to the first slider and at its distal end to the outer sheath at a distal end of the outer sheath and a second wire operatively coupled at its proximal end to the second slider and at its distal end to the outer sheath at the distal end of the outer sheath;
wherein the first wire and the second wire deflect the deflectable portion when the actuator is manipulated; and
wherein the outer sheath is operatively coupled to an anchoring ring at the distal cutting end and wherein the anchoring ring is located between the outer sheath and the rotatable cutting shaft.

US Pat. No. 10,478,207

SURGICAL GRASPER

Vanderbilt University, N...

1. A surgical grasper comprising:a first handle arm;
a second handle arm coupled to the first handle arm; and
a lock that locks relative movement between the first and second handle arms, the lock including:
a first ratchet arm fixed to the first handle arm;
a second ratchet arm coupled to the second handle arm;
a pusher element slidably coupled to the second ratchet arm that moves the second ratchet arm toward and away from the first ratchet arm; and
a lockout element releasably coupled to the pusher element that locks a position of the pusher element.

US Pat. No. 10,478,203

SNARE INSTRUMENT WITH SNARE STRUCTURE FORMED FROM A TUBE SECTION

1. A snare instrument comprisingan enclosure; and
a snare structure placed in the enclosure, where the snare structure is formed by a tube section that extends from a proximal end of a proximal base portion to a distal end of a distal snare portion, the tube section including:
a plurality of open slits formed in the distal end of the tube section, with each open slit extending a distance L in an axial direction toward the proximal base portion, and
a plurality of closed wire sections, with each closed wire section located between a first open slit of the plurality of open slits and a second open slit of the plurality of open slits adjacent to the first open slit, where each closed wire section is formed by a channel opening, and the channel opening is spaced a distance Bd away from the distal end of the tube section such that the closed wire section is closed at the distal end of the tube section by a curved wire section, where the curved wire section has a radius of curvature R;
wherein the channel opening is semi-circular and the radius of curvature R of the curved wire section is at least a factor of 2.5 greater than the distance Bd;
wherein the snare structure is movable between a snaring position characterized by the snare structure moved forward in a distal direction out of the enclosure and a securing position characterized by the snare structure moved back in a proximal direction into the enclosure;
wherein, when in the snaring position, the snare structure forms a cup shape having a distal snare opening that is approximately circular;
wherein n is defined as a number of the plurality of open slits, and a circumferential length of the distal snare circular opening is 70% or more of the product of 2 nL.

US Pat. No. 10,478,199

METHODS, SYSTEMS, AND DEVICES FOR DIAGNOSING AND TREATING INTERVERTEBRAL DISC DEGENERATION

Trinity Orthopedics, LLC,...

1. A method of accessing an intervertebral disc located within an intervertebral disc space adjacent a vertebra having a pedicle, a vertebral body and a vertebral endplate, the method comprising:positioning a first cannula within the vertebra substantially along an axis of the pedicle, the cannula coursing, at least in part, along a first curvilinear path at a first trajectory through at least a portion of the vertebral body to the vertebral endplate;
advancing a translatable flexible curvilinear bone penetrating instrument through a lumen of the first cannula; and
penetrating the vertebral endplate with the translatable flexible curvilinear bone penetrating instrument to enter into the intervertebral disc space thereby creating a first defect in the vertebral endplate at a first location;
repeating the positioning, the advancing, and the penetrating steps thereby creating a plurality of additional defects in the vertebral endplate at additional unique locations;
wherein trajectories of additional curvilinear paths are the same as or different from the first trajectory of the first curvilinear path.

US Pat. No. 10,478,196

COMPRESSION DEVICE AND PRESSURE SENSOR FOR TREATMENT OF ABNORMAL UPPER ESOPHAGEAL SPHINCTER FUNCTIONALITY

The Medical College of Wi...

1. A compression device for reducing pharyngeal reflux in a subject, the compression device comprising:a frame;
a clasp;
a strap having a first end section attached to the frame and an opposite second end section attached to the clasp, a length of the strap between the first end section and the second end section being adjustable; and
a cushion disposed on the frame, wherein the clasp is configured to engage at least a portion of the frame, such that the clasp fastens the strap to the frame to position the cushion over a cricoid of the subject and to apply a predetermined amount of pressure to the cricoid in order to reduce pharyngeal reflux in the subject while allowing the subject to open an upper esophageal sphincter of the subject for other physiological events;
an adjustment mechanism for moving the cushion toward or away from the frame, wherein the adjustment mechanism comprises a plate and a position adjustor movably attached to the plate, the position adjustor being located on a first side of the frame, the plate having a first surface and an opposite second surface, the first surface of the plate being attached to the cushion, the second surface of the plate being in contact with a second side of the frame; and
wherein the clasp is configured to unfasten the strap from the frame and to refasten the strap to the frame to reapply the predetermined amount of pressure to the cricoid.

US Pat. No. 10,478,195

DEVICES, SYSTEMS, AND METHODS FOR THE TREATMENT OF VASCULAR DEFECTS

Covidien LP, Mansfield, ...

1. A vascular occlusion device for treating an aneurysm, wherein a neck of the aneurysm opens to a blood vessel, the device comprising:a proximal portion having a mesh configured to be positioned within the aneurysm;
a distal portion including a directing region having:
a proximal terminus that coincides with a proximal terminus of the distal portion,
a distal terminus, wherein the directing region extends along a first direction that runs through the proximal terminus and the distal terminus, and
a length measured along the first longitudinal direction between the proximal terminus and the distal terminus; and
an intermediate mesh portion between the proximal and distal portions that, when in a deployed configuration, forms a preset bend in the device that orients the first longitudinal direction of the directing region at an angle to a portion of the proximal portion adjacent the intermediate mesh portion, wherein the angle is between about 45 degrees and about 135 degrees, and
wherein, when the device is being pushed distally out of a delivery catheter into the aneurysm, the directing region directs the distal portion to inhibit the distal portion from exiting the aneurysm through the neck such that the proximal portion crosses the neck and generally remains within the aneurysm,
wherein the device is configured to be implanted within the aneurysm.

US Pat. No. 10,478,194

OCCLUSIVE DEVICES

Covidien LP, Mansfield, ...

1. An implant for occluding a target area of a patient's vasculature, comprising:a frame comprising a lattice formed of a first plurality of braided filaments that define a first plurality of openings, the first openings having a pore size of from about 1 ?m to about 400 ?m, the frame comprising a distal region and a proximal region, the frame being expandable from a compressed configuration to an expanded configuration in which the frame has a generally spherical shape, and wherein the first plurality of filaments are coupled together at a hub disposed at a proximal end of the frame;
a first mesh component coupled to the frame along at least a first portion of the proximal region, the first mesh component comprising a second plurality of braided filaments that define a second plurality of openings, the second pluralities of filaments and openings collectively defining a mesh porosity permitting blood flow therethrough, the mesh porosity being less than a porosity of the frame, such that blood flow into the implant is more restricted along the proximal region than along the distal region of the frame; and
a second mesh component coupled to the frame along at least a second portion of the proximal region, the second portion differing from the first portion, the second mesh component comprising a third plurality of braided filaments that define a third plurality of openings,
wherein a proximal end of the implant is configured to be detachably coupled to a delivery device.

US Pat. No. 10,478,191

BUTTRESS ATTACHMENT FOR CIRCULAR STAPLING DEVICE

Covidien LP, Mansfield, ...

1. An anvil assembly, comprising:a circular anvil head having a first engaging feature and supporting a crush ring member;
an anvil cap having a second engaging feature that connects with the first engaging feature of the anvil head to secure the anvil cap to the anvil head, the anvil cap being movable relative to the anvil head between an approximated position and an unapproximated position, the crush ring member being spaced from the second engaging feature when the anvil cap is disposed in the approximated position and movable into engagement with the second engaging feature to move the anvil cap to the unapproximated position; and
a circular anvil buttress member including a body portion and an extension portion that extends from the body portion, the body portion supported on a tissue engaging surface of the anvil head, the extension portion being secureable between the anvil cap and the anvil head when the anvil cap is disposed in the approximated position, the extension portion being releasable from between the anvil cap and the anvil head when the anvil cap is disposed in the unapproximated position so that the body portion separates from the tissue engaging surface of the anvil head.

US Pat. No. 10,478,183

ADJUNCT RELEASE FOR SURGICAL STAPLERS

Ethicon LLC, Guaynabo, P...

1. A staple cartridge assembly for use with a surgical stapler, comprising:a cartridge body having a plurality of staple cavities on a tissue-facing surface thereof, each staple cavity having a staple disposed therein that is configured to be deployed into tissue, and the cartridge body having a plurality of connection cavities separate from the plurality of staple cavities on the tissue-facing surface;
an adjunct disposed on the tissue-facing surface of the cartridge body, the adjunct having a plurality of protrusions disposed on an adjunct surface configured to contact the tissue-facing surface, the plurality of protrusions being configured to extend into and engage with the plurality of connection cavities; and
a plurality of drivers disposed within the cartridge body, each driver having at least one adjunct releasing mechanism located thereon such that the plurality of drivers are configured to drive the plurality of protrusions of the adjunct out of the plurality of connection cavities and cause the adjunct to detach from the cartridge body when the plurality of drivers are advanced into the staple cavities to deploy the staples.

US Pat. No. 10,478,180

SLITTED TISSUE FIXATION DEVICES AND ASSEMBLIES FOR DEPLOYING THE SAME

EndoGastric Solutions, In...

1. A method for mounting a fastener onto a deployment wire, comprising:providing a fastener and a deployment wire, the fastener including a first member and a second member, connecting the first member to the second member by a connecting member that is not the deployment wire, only the first member having a through channel dimensioned to be slidingly received on the deployment wire and a slit configured to be made larger so that the deployment wire can be snapped onto and released from the through channel;
the slit having a first elongated edge and a second elongated edge, the first and second elongated edges being spaced apart; and
snapping the deployment wire through the slit and into the through channel by moving the first and second elongated edges farther apart to accommodate the deployment wire.

US Pat. No. 10,478,178

SUTURE WITH TRIM FORMED TIP

Ethicon, Inc., Somervill...

1. A monofilament suture having a formed distal tip, comprising;a suture filament having a body, proximal end and a distal end, the body of the suture having a maximum cross-sectional dimension;
a tip section on the distal end, the tip section having a configuration with an outer perimeter comprising at least first and second opposed arcuate sections joined together by opposed first and second flat or linear sections that are substantially parallel to each other, and a cross-section having a maximum dimension, wherein the maximum dimension of the cross-section of the tip section is less than the maximum cross-sectional dimension of the body of the suture;
a transition section between the suture filament body and the tip section, the transition section tapering from the suture filament body to the tip section to transition from a diameter of the suture filament body to a diameter of the tip section; and
lateral trim regions in the distal end extending through the transition section into at least a portion of the tip section, the lateral trim regions comprising connected opposed arced portions.

US Pat. No. 10,478,177

SYSTEMS AND METHODS FOR INCREASED OPERATING ROOM EFFICIENCY

SHARP FLUIDICS LLC, Hayw...

1. A needle receptacle comprising:a housing comprising a lower structure and an upper structure,
wherein the upper structure comprises an optically transmissive material and the lower structure comprises an optically transmissive material in order to view needles within a secure zone of the receptacle with backlight illumination,
wherein the upper structure has a longitudinal slot to receive a needle driver, and
wherein the secure zone comprises an elongate needle slot to receive a plurality of needles, the elongate needle slot extending between the upper structure and the lower structure, and wherein needles in the needle slot can be viewed through the upper structure with the backlight illumination through the lower structure.

US Pat. No. 10,478,166

LAPAROSCOPIC MORCELLATING RECEPTACLE AND METHODS OF USE

1. A morcellation receptacle system comprising:a collapsible and expandable receptacle, having a vertical axis with a lower half section with a distal area, and an upper half section with a proximal end, and a horizontal axis, configured such that when the collapsible receptacle is collapsed on its horizontal axis, it is linearly sized to fit within and through an opening between 14-20 mm in width but not when expanded in a natural open position; said receptacle comprising:
a plurality of at least three support rods positioned in a circumferential and equidistant manner around the vertical axis, or substantially so, having distal ends coupled to the distal area of the receptacle and having proximal ends extending proximally and laterally away from the distal area and configured to have natural spring tension such that the support rods are expanded, away from each other in a natural, open, position, and move towards each other on the horizontal axis when the receptacle is collapsing and move away from each other on the horizontal axis when the receptacle is opening,
a flexible liner that is water resistant, low-friction, tear-resistant, and made of material different from the support rods, having a thickness between 0.05-0.15 mm, wrapped along the support rods such as to define a bag with a closed end at the distal area;
and a cover made of a thin flexible material that is permanently attached to a perimeter of the proximal end of the receptacle, such that the cover and the perimeter of the proximal end of the receptacle are expandable and collapsible to fit through the 14 to 20 mm opening and the cover establishes a surface area having a plurality of premade holes configured to allow a trocar sleeve to pass through into the receptacle along the vertical axis when the receptacle is in a natural expanded position, and wherein the cover comprises a substantially central opening configured to be releasably closable, such that at least 75% of area of the substantially central opening is occluded, while the perimeter of the proximal end of the receptacle is maintained in its expanded natural, open position and the plurality of premade holes individually remain accessible for the trocar sleeve to pass through into the receptacle along the vertical axis.

US Pat. No. 10,478,161

TISSUE CUTTING MEMBER FOR A BIOPSY DEVICE

SenoRx, Inc., Franklin L...

1. A method for forming a tissue cutting member to separate a tissue specimen from a target site within a patient's body, comprising:providing a distal tubular portion including a side wall defining a lumen, a longitudinal axis, and a flared distal section;
configuring the flared distal section to include an inclined distal tip at a distal end of the side wall and an outwardly flared distal tubular portion that defines an inner tissue receiving aperture, the inclined distal tip having a beveled front face with a leading cutting edge and a trailing cutting edge, the outwardly flared distal tubular portion being outwardly flared in a distal direction to the leading cutting edge;
providing a single longitudinally oriented opening in the side wall in the flared distal section which radially opens to the lumen, the single longitudinally oriented opening having an open distal end and extending from a closed proximal end to the open distal end; and
providing a relief opening at the closed proximal end, the relief opening having a transverse dimension larger than a transverse dimension of the single longitudinally oriented opening adjacent the relief opening, the single longitudinally oriented opening diverging from the closed proximal end to intersect the trailing cutting edge of the beveled front face of the inclined distal tip of the distal tubular portion and facilitating formation of the outwardly flared distal tubular portion.

US Pat. No. 10,478,157

METHODS FOR DRUG DELIVERY

PRESAGE BIOSCIENCES, INC....

1. A method of delivering one or more agents to a solid tumor of a subject, comprising:(a) inserting one or more needles of a needle array device into said solid tumor, said needle array device comprising five or more needles and one or more agents; and
(b) injecting said one or more agents into said solid tumor via said one or more needles of said needle array device while simultaneously withdrawing said one or more needles from said solid tumor.

US Pat. No. 10,478,154

ULTRASOUND SENSOR ELEMENT, ULTRASOUND SENSOR ARRAY ASSEMBLY, ULTRASOUND TRANSMIT SENSOR ELEMENT, IMAGING DEVICE, ULTRASOUND TRANSDUCER, AND METHOD OF PERFORMING AN ULTRASOUND SCAN

Sharp Kabushiki Kaisha, ...

1. An ultrasound sensor array assembly comprising a two dimensional array of ultrasound sensor elements, each sensor element in the two dimensional array of ultrasound sensor elements comprising:an ultrasound transducer,
a transmit circuit configured to provide an electrical signal to the transducer for output of an ultrasound signal; and
a receive circuit configured to receive an electrical signal from the transducer, based on a received reflected ultrasound signal,
wherein the transmit and receive circuits each comprise one or more thin film transistors;
the sensor array assembly further comprising:
a plurality of transmit delay circuits, wherein each transmit delay circuit is in electrical communication with each sensor element in a row of the array of sensor elements, and wherein the transmit delay circuits are configured to delay a transmit signal to the sensor elements in each row for steering a beam of emitted ultrasound; and
a plurality of receive delay circuits, wherein each receive delay circuit is in electrical communication with each sensor element in a column of the array of sensor elements, and wherein the receive delay circuits are configured to delay a receive signal from the sensor elements in each column for steering the beam of received reflected ultrasound;
wherein the plurality of transmit delay circuits are incorporated into a first driver circuit, and the plurality of receive delay circuits are incorporated into a second driver circuit, and the first and second driver circuits are located external and adjacent to the two dimensional array of ultrasound sensor elements.

US Pat. No. 10,478,150

MEDICO—SURGICAL DEVICES

The Cooper Companies Glob...

1. An embryo replacement catheter comprising:a hub; and
a shaft attached to the hub, the shaft having a bore extending therethrough, the shaft comprising a wall of a transparent plastic material with gas bubbles incorporated therein,
wherein the gas bubbles extend through a major part of a thickness of the wall of the shaft, and the gas bubbles have a density and size to enable visibility of the catheter under ultrasound imaging and to enable an embryo within the bore of the shaft to be viewed by a naked eye of a user.

US Pat. No. 10,478,148

SELF-CALIBRATING PROJECTION GEOMETRY FOR VOLUMETRIC IMAGE RECONSTRUCTION

The Johns Hopkins Univers...

1. A method for self-calibrating projection geometry for a volumetric image reconstruction comprising:selecting a prior volumetric representation of a patient;
dividing a cone-beam computed tomography (CBCT) scan from a CBCT scanner to be self-calibrated into a number of projections;
selecting a projection from the number of projections;
registering the projection to the prior volumetric representation in order to determine a 9-degree-of freedom geometric calibration of the selected projection;
applying the 9-degree-of-freedom geometric calibration of the selected projection;
generating a projection matrix from the 9-degree-of-freedom geometric calibration of the selected projection; and
generating and displaying a three-dimensional, volumetric reconstruction of the CBCT scan using a plurality of the projection matrix for self-calibration of the CBCT scanner.

US Pat. No. 10,478,144

X-RAY IMAGING APPARATUS AND IMAGING METHOD USING THE SAME

SHIMADZU CORPORATION, Ky...

1. An X-ray imaging apparatus, comprising:an X-ray irradiation detection element including an X-ray irradiation element that irradiates an X-ray to a subject and an X-ray detection element that detects said X-ray transmitting through said subject;
a table that is enabled to load said subject on a loading plane;
a driving element that relatively moves said table relative to said X-ray irradiation detection element; and
a control element that controls a to move of at least one of said table and said X-ray irradiation detection element by said driving element based on a pre-registered pathway information when imaging said subject;
wherein said control element acquires an information as a representative point that is relative to a location at which said table and said X-ray irradiation detection element suspend moving relative to each other y based on either that a relative moving between said table and said X-ray irradiation element suspends, or that once the relative moving between said table and said X-ray irradiation detection element is suspended and then said relative moving between said table and said X-ray irradiation detection element restarts after said table and said X-ray irradiation detection element are relatively moved by at least one of a manual element and or a driving element, and registers said pathway information based on said acquired representative point.

US Pat. No. 10,478,143

SYSTEM AND METHOD OF GENERATING AND UPDATNG A THREE DIMENSIONAL MODEL OF A LUMINAL NETWORK

COVIDIEN LP, Mansfield, ...

1. A method of updating a model of a luminal network, comprising:generating 3D image data including fiducial markers disposed at a first location using images captured in a first imaging of a target;
generating 2D image data including the fiducial markers disposed at a second location using images captured in a second imaging of the target, the second imaging of the target including imaging of the target from a first viewpoint and imaging the target from a second viewpoint, the first and second viewpoints oriented at a known angle relative to each other;
determining the second location of the fiducial markers in 3D space based on the second location of the fiducial markers within the 2D image data of the first viewpoint, the second location of the fiducial markers within the 2D image data of the second viewpoint, and the known angle;
comparing the first location of the fiducial markers in the 3D image data to the second location of the fiducial markers in 3D space;
determining a difference between the first location of the fiducial markers in the 3D image data and the second location of the fiducial markers in 3D space based on the comparison;
updating the 3D image data generated using images captured in the first imaging with the determined second location of the fiducial markers in 3D space based on the determined difference;
displaying the updated 3D image data including the fiducial markers disposed at the second location of the fiducial markers in 3D space;
determining movement distances between the second location of the fiducial markers in 3D space and the first location of the fiducial markers in the 3D image data from the first imaging;
determining which of the movement distances exceeds a threshold; and
registering the 3D image data generated using images captured in the first imaging with the determined second location of the fiducial markers in 3D space, wherein the registering excludes the second location in 3D space of the fiducial marker corresponding to movement distances that exceed the threshold.

US Pat. No. 10,478,141

METHOD FOR ESTIMATING THE DISTRIBUTION OF BONE MINERAL DENSITY IN AT LEAST ONE PORTION OF A PERSON'S SKELETON

AMVALOR, Paris (FR)

1. An estimation method for estimating the bone mineral density distribution in at least one portion of a person's skeleton, the skeleton being made up of bone tissue, the bone tissue being surrounded by soft tissue, in turn surrounded by an outline (E) of the person, the method being characterized in that it comprises generating:a geometrical representation in three dimensions of said portion of the person's skeleton;
a geometrical representation in three dimensions of at least one portion of the outline (E) containing said portion of the person's skeleton;
at least one first X-ray image of said at least one portion of the skeleton, this first image being generated by observing a projection onto a first detection surface of X-rays, coming from a first source, the first image being generated by projecting X-rays and representing the person as observed from a first observation angle of incidence; and
at least one second X-ray image of said at least one portion of the skeleton, the second image being generated by projecting X-rays and representing the person as observed from a second observation angle of incidence distinct from the first observation angle of incidence; and then
using predetermined software and for a plurality of given X-rays selected from among said projected X-rays, estimating for each given X-ray:
a value for the thickness of soft tissue through which the given X-ray has passed;
a value for the thickness of bone tissue through which the given X-ray has passed; and
a value for the overall attenuation of the given X-ray between its source and its projection onto the detection surface onto which it is projected; and
using the thickness value for soft tissue through which the given X-ray passes, and using an estimate for an attenuation coefficient of the soft tissues through which the given X-ray passes, deducing firstly a value for the attenuation of the given X-ray due to the thickness of soft tissue through it has passed and secondly a value for the attenuation of the given X-ray due to the thickness of bone tissue through which it has passed; and then
using the value for the thickness of bone tissue through which the given X-ray has passed, the value for the attenuation of the given X-ray due to the thickness of bone tissue through which it has passed, and the overall value for attenuation of the given X-ray, the software estimates a value representative of the bone mineral density of the bone tissue through which the given X-ray has passed.

US Pat. No. 10,478,139

COMPUTED TOMOGRAPHY SYSTEM HAVING COOLING SYSTEM

Samsung Electronics Co., ...

1. A cooling system of a computed tomography (CT) system, comprising:a gantry having a bore therein; and
a table that moves into and out of the bore of the gantry,
wherein the gantry comprises a part box mounted therein, and blade elements that are formed in regions of the part box are arranged to control an air flow inside the gantry,
wherein the part box is an external housing for a part,
wherein the part comprises one or more of an X-ray generator, an X-ray detector, a data acquisition system (DAS), a power supplier, a heat exchanger (HX), an high voltage generator (HVG),or a wireless transducer for each part box,
wherein the part box comprises an inlet hole and an exhaust hole arranged in one or more surfaces of the part box, and the blade elements are fixed on an inner surface of the part box,
wherein one edge of each of the blade elements is exposed at a surface of the part box through the inlet hole, and another edge of each of the blade elements extends toward an inner side of the inlet hole of the part box, and
wherein an extended portion between the one edge and the another edge in each of the blade elements is not visible through the inlet hole of the part box.

US Pat. No. 10,478,137

MULTIPLE IMAGING MODALITY IMAGING APPARATUS

KONINKLIJKE PHILIPS N.V.,...

1. An imaging apparatus, comprising:a first imaging modality;
a second imaging modality, wherein the first and second imaging modalities are in alignment with scanning zones for scanning an object or subject;
a third imaging modality which is selectively moveable between a first location in which the third imaging modality is in alignment with the scanning zones for scanning the object or subject and a second location in which the third imaging modality is outside of alignment with the scanning zones; and
an alignment unit that supports the third imaging modality, wherein the alignment unit provides adjustment of at least of a position or orientation of third imaging modality with respect to the scanning zones and provides angular variation in rotation around X and Z axes.

US Pat. No. 10,478,136

RADIOLOGICAL DOSING SYSTEM AND METHOD

Certa Dose, Inc.

1. A method of administering radiation to a patient, the method comprising:receiving, at a processor associated with a radiation device, information indicating that a patient is associated with a coded region included among a plurality of coded regions wherein each of the plurality of coded regions corresponds to one or more values of a physical characteristic wherein the processor determines a patient size;
receiving, at the processor, a radiation location for the patient;
determining, at the processor and based on the patient size, a safe range of radiation for the patient;
correlating, at the processor, the coded region and the radiation location with a dose of radiation; and
applying the dose of radiation to the patient at the radiation location.

US Pat. No. 10,478,135

UROLOGY TABLE WITH TILTABLE X-RAY TUBE

STORZ MEDICAL AG, Tagerw...

1. A urological device oriented with respect to a Cartesian system of coordinates defined by an x-axis, a y-axis, and a z-axis, the device comprising:a patient table having a longitudinal side aligned with the x-axis, and a broad side aligned with the y-axis, wherein the z-axis extends above and below the patient table in a direction transverse to the patient table;
an X-ray source mounted above the patient table and configured to emit a beam of X-ray radiation directed to the patient table,
an X-ray detector mounted below the patient table and configured to detect the X-ray radiation that has been emitted by the X-ray source and that has passed through a patient on the patient table,
an X-ray source linear drive configured to move the X-ray source parallel to the y-axis,
a pivot mechanism configured to pivot the X-ray source about a first pivot axis and in a plane parallel to the y-axis and z-axis,
an X-ray detector linear drive configured to move the X-ray detector parallel to the y-axis without tilting the X-ray detector,
and
a control unit operably connected with the X-ray detector and X-ray source and configured to coordinate
(i) a first movement of the X-ray source in a first direction
with
a unidirectional second movement of the X-ray detector in a second direction that is opposite to the first direction,
and
(ii) pivoting of the X-ray source to position the X-ray source for directing the X-ray beam to the detector at different angles,
such as to have a center of the X-ray beam aligned with a center of the X-ray detector at each position of the X-ray detector.

US Pat. No. 10,478,130

PLAQUE VULNERABILITY ASSESSMENT IN MEDICAL IMAGING

Siemens Healthcare GmbH, ...

1. A method for assessing plaque vulnerability of a patient in medical imaging, the method comprising:extracting an anatomical feature of a vessel or plaque and a morphological feature of the plaque from a scan of the patient by a medical imaging scanner;
obtaining a hemodynamic feature of the patient from a hemodynamic sensor or personalized modeling of the vessel based on the scan;
receiving at an interface a biochemical feature from a blood test of the patient, the biochemical feature including a level of high sensitive troponin;
calculating by a machine-implemented classifier a risk score for plaque rupture for the patient and a risk stratification, both the risk score and risk stratification calculated by the machine-implemented classifier from the anatomical, morphological, hemodynamic, and biochemical features; and
transmitting the risk score for the patient to a display.

US Pat. No. 10,478,128

HEART RATE DETECTION ARCHITECTURE

PIXART IMAGING INC., Hsi...

13. A heart rate detection device, configured to receive a photoplethysmography (PPG) raw data from a PPG detector and a microelectromechanical systems (MEMS) raw data from a MEMS accelerometer, the heart rate detection device comprising:a PPG hardware module configured to receive the PPG raw data, the PPG hardware module comprising:
a first bandpass filter configured to filter the PPG raw data;
a first conversion module configured to convert the filtered PPG raw data to PPG spectrum values and PPG frequency index; and
a first peak extraction module configured to search PPG peak spectrum values among the PPG spectrum values, and output the PPG peak spectrum values and the PPG frequency index;
a MEMS hardware module configured to receive the MEMS raw data, the MEMS hardware module comprising:
a second bandpass filter configured to filter the MEMS raw data;
a second conversion module configured to convert the filtered MEMS raw data to MEMS spectrum values and MEMS frequency index; and
a second peak extraction module configured to search a MEMS peak spectrum value among the MEMS spectrum values, and output the MEMS peak spectrum values and the MEMS frequency index; and
a microcontroller unit (MCU), electrically coupled to the PPG hardware module and the MEMS hardware module, and configured to estimate a heart rate according to the PPG peak spectrum values, the PPG frequency index, the MEMS peak spectrum values and the MEMS frequency index by
determining a reference index according to a frequency index corresponding to the MEMS peak spectrum value in the MEMS spectrum values,
determining a denoising range according to the reference index,
removing the PPG spectrum values in the PPG spectrum values corresponding to the denoising range to generate denoised PPG frequency data, and
calculating the heart rate according to a PPG peak spectrum value of the denoised PPG frequency data,
wherein the PPG hardware module outputs the PPG peak spectrum values as well as the PPG frequency index and the MEMS hardware module outputs the MEMS peak spectrum value as well as the MEMS frequency index without MCU operation to share loading of the MCU, and
wherein the estimated heart rate is configured to be shown on a display.

US Pat. No. 10,478,127

APPARATUSES, METHODS, PROCESSES, AND SYSTEMS RELATED TO SIGNIFICANT DETRIMENTAL CHANGES IN HEALTH PARAMETERS AND ACTIVATING LIFESAVING MEASURES

Sherlock Solutions, LLC, ...

54. A system comprising:a biometric apparatus including a biometric sensor wearable by a user and situationally calibratable based on a physically-measured value of said user measured by said system during a movement of said user, said biometric sensor configured to measure biometric data from said user and generate one or more processed signals based on said biometric data; and
at least one primary processor in communication with said biometric sensor, said at least one primary processor receiving said one or more processed signals, said at least one primary processor determining whether said user has experienced a physiological change based on one or more changes in at least one of a QRS complex or a Peak-Peak interval, said at least one primary processor determining whether said physiological change is a detrimental change or a not detrimental change based on a comparison of one or more health parameters generated based on said one or more processed signals, said at least one primary processor determining an action based on whether said physiological change is said detrimental change or said not detrimental change, said action including automatically notifying at least one of said user, an emergency medical system, or a remote device identifying whether said physiological change is said detrimental change or said not detrimental change.

US Pat. No. 10,478,124

PRESSURE SENSOR TO DETECT BODY SOUNDS

Cardiac Pacemakers, Inc.,...

1. A system, comprising:a pressure sensor configured to receive physiologic information from a patient; and
a control circuit, coupled to the pressure sensor, configured to receive information from the pressure sensor, and to control a state of the pressure sensor, wherein the control circuit is configured to:
detect pressure information from the patient using the physiologic information received by the pressure sensor in a first state; and
detect body sound information from the patient using the physiologic information received by the pressure sensor in a second state.

US Pat. No. 10,478,123

ELASTIC SENSOR FOR MEASURING VITAL PARAMETERS IN THE AUDITORY CANAL

Cosinuss GmbH, Munich (D...

1. A sensor for measuring a vital parameter in the auditory canal (8) of a person or an animal, comprising:a sensor element fixture (2), which is positionable at least partially in the auditory canal (8),
a sensor element (1), which is connectable to the sensor element fixture (2) and is positionable at least partially in the auditory canal (8), and
a positioning element (3), suitable for positioning the sensor element fixture (2) in the auditory canal (8), wherein at least one end of the positioning element (3) is connectable to the sensor element fixture (2),
wherein the position of the sensor element (1) within the auditory canal (8) is determined by the insertion depth of the sensor element fixture (2) in the auditory canal (8), and
wherein the positioning element (3) exhibits a suitable shape relating to the anatomy of the interior face of the auricle, and is suitable for pushing the sensor element fixture (2) into the interior of the auditory canal such that the sensor is held firmly and a continuous measurement of the vital parameter occurs in the auditory canal (8) characterized in that
the sensor element (1), the sensor element fixture (2) and the positioning element (3) are arranged at least partially in a housing (4) and the housing (4) is adaptable to the anatomy of at least part of the head of the person or the animal, wherein the housing (4) is at least partially elastic, the housing (4) is rotatable and/or size adjustable, the housing (4) comprises a piston and a guide wherein the piston is at least partially aligned in the guide, the piston and/or the guide are arranged with a material comprising a plastic, a rubber, a silicone and/or an elastomer such that they may be pulled apart in the 0° position and such that a rotation of up to ?120° or +120° results in a deadlock, wherein the 0° position lies in a plane parallel to the sagittal plane of the head.

US Pat. No. 10,478,121

DEVICE AND METHOD FOR DETERMINING AN INCORRECT POSITIONING IN THE ALIGNMENT OF PROSTHESES

1. A method for determining positions for alignment of a prosthetic foot relative to a lower leg tube as part of an alignment of a lower extremity device, comprising:establishing, using sensor data measured by at least one inertial sensor connected to the lower extremity device, over at least one gait cycle for a treated extremity, at least one of inertial measurement data and variables derived from the inertial measurement data for the treated extremity, the inertial measurement data comprising absolute angles of a lower leg and a thigh of the treated extremity;
determining a knee angle of the lower leg and the thigh from the absolute angles of the lower leg and thigh;
comparing the inertial measurement data and the knee angle with intended values;
determining positions for alignment of the prosthetic foot relative to the lower leg tube based on the comparing.

US Pat. No. 10,478,119

SYSTEM AND METHOD FOR DRUG DOSAGE MEDICAMENT REGIME ADHERENCE MONITORING

1. A method for oral drug dosage medicament regime adherence monitoring comprising:creating an oral drug dosage medicament regime for a patient, the medicament regime having a plurality of medicament intervals for the oral consumption of a plurality of oral drugs,
loading the plurality of oral drugs into a cartridge of an oral drug dispensing device;
providing a patient wearable vital sign monitoring device for being worn by the patient,
associating the patient wearable vital sign monitoring device and the oral drug dispensing device with a patient profile, the patient profile being further associated with the oral drug dosage medicament regime, wherein, for at least one medicament interval, the method comprises:
alerting the patient of the medicament interval using at least one of the patient wearable vital sign monitoring device and the oral drug dispensing device;
obtaining first vital sign measurement data for the patient using the patient wearable vital sign monitoring device;
detecting the dispensing of an oral drug from the cartridge of the of oral drug dispensing device;
ascertaining the proximity of the patient wearable vital sign monitoring device and the oral drug dispensing device at substantially the same time as the detecting of the dispensing of the oral drug from the cartridge;
obtaining second vital sign measurement data for the patient post the dispensing using the patient wearable vital sign monitoring device, and
comparing the first and second vital sign measurement data to calculate a probability of the oral consumption of the oral drug.

US Pat. No. 10,478,118

METHOD AND DEVICE FOR SLEEP ANALYSIS

Cleveland Medical Devices...

1. A method of remote sleep analysis and diagnosis comprising the steps of:a) providing a patient with a portable patient interface box adapted to be worn by the patient and a nasal cannula or a facemask, a respiratory effort belt and a fingertip pulse oximeter, the patient interface box comprising a battery, at least one kinetic sensor, a nonvolatile digital memory, first and second pressure transducers, a first air port for connecting the nasal cannula or the facemask to the first pressure transducer, a second air port for connecting the respiratory effort belt to the second pressure transducer, and a releasable connector sensor input to electrically connect and disconnect the fingertip pulse oximeter, the nasal cannula or facemask for measuring airflow of the patient, the respiratory effort belt for measuring respiratory effort of the patient, the kinetic sensor for measuring body position or orientation, and the fingertip pulse oximeter for measuring oxygenation of the patient;
b) applying and connecting the nasal cannula or facemask, the respiratory effort belt and the fingertip pulse oximeter to the patient, and further the patient interface box to the patient;
c) measuring and collecting data from the sensors through the patient interface box of the airflow, respiratory effort, body position or orientation and oxygenation of the patient in a remote sleep location from the sleep unit or lab while the patient is attempting to sleep;
d) digitizing and storing the collected data from the patient in the nonvolatile digital memory of the patient interface box;
e) to the sleep analysis unit or lab or to a database accessible to individuals from the sleep analysis unit or lab;
f) providing a computer or processor for analyzing the transferred collected data to identify and draw attention to physiological or technological events in the data indicative of a sleeping disorder; and
g) further analyzing at a minimum the transferred collected data and/or the physiological or technological events in the data at the sleep analysis unit or lab, or at a location remote from the remote sleep location to determine whether the patient suffers from a sleeping disorder.

US Pat. No. 10,478,114

BRAIN DYSFUNCTION ASSESSMENT METHOD, BRAIN DYSFUNCTION ASSESSMENT DEVICE, AND PROGRAM THEREOF

MAXELL, LTD., Kyoto (JP)...

1. A measurement method for cerebral dysfunction evaluation, the method comprising:providing a subject with a touch enabled computer, wherein the touch enabled computer includes one or more sensors that measure a position of a touch gesture by a first hand or a second hand of the subject;
acquiring, using the one or more sensors, a response time and position accuracy for a plurality of prescribed touch gestures performed by the subject, where the response time and the position accuracy for each of the plurality of prescribed touch gestures are acquired by:
displaying, using the display, a target with a known position on the display,
detecting, using the one or more sensors, a touch gesture performed in response to the displaying,
determining, by a processor of the touch enabled computer, the position of the touch gesture detected,
calculating, by the processor, an elapsed time from the displaying to the detecting as the response time, and
calculating, by the processor, a difference between the known position and the position of the touch gesture performed in response to the displaying as the position accuracy; and
generating evaluation data for cerebral dysfunction evaluation based on a correlation between the response time and the position accuracy for the plurality of prescribed touch gestures performed by the subject.

US Pat. No. 10,478,113

BLADDER EVENT DETECTION FOR DIAGNOSIS OF URINARY INCONTINENCE OR TREATMENT OF LOWER URINARY TRACT DYSFUNCTION

THE CLEVELAND CLINIC FOUN...

1. A system comprising:a sensing device adapted to be implanted within a patient's bladder, comprising:
a pressure sensor comprising a bridge-type circuit adapted to directly detect a pressure within the patient's bladder;
a wireless transceiver adapted to transmit a signal indicating the pressure within the patient's bladder; and
a battery adapted to provide power to the pressure sensor,
wherein at least one of the circuit, the wireless transceiver, and the battery is sealed within a biocompatible housing; and
a signal processing device comprising:
a wireless transceiver adapted to receive the signal indicating the detected pressure within the patient's bladder;
a processor to execute instructions stored in memory to process the signal and at least:
filter the signal indicating the detected pressure with a low-pass filter with a cutoff frequency tuned for the patient to provide a filtered signal;
apply a multi-level discrete wavelet transform to the filtered signal to provide a transformed signal in a wavelet domain;
apply an adaptive thresholding procedure to the transformed signal in the wavelet domain to detect a bladder event and characterize the bladder event as a voiding contraction event, a non-voiding contraction event, or a non-contraction event based on at least one property of the bladder event according to one or more tunable parameters customized for the patient.

US Pat. No. 10,478,108

ANALYTE MONITORING DEVICE AND METHODS OF USE

Abbott Diabetes Care Inc....

1. A physiological monitoring system, comprising:an analyte sensor to generate signals corresponding to monitored analyte level in bodily fluid under a skin surface of a user;
a motion detector to monitor an activity level of the user corresponding to a completed exercise activity by the user;
a processor operatively coupled to the analyte sensor and the motion detector to determine a previously monitored variation in the analyte level monitored by the analyte sensor based on the monitored activity level of the user, to receive a user-determined bolus quantity, to enable a therapy device to deliver the user-determined bolus quantity, to determine that the determined previously monitored variation in the analyte level exceeds a predetermined threshold, and in response to the determined previously monitored variation in the analyte level exceeding the predetermined threshold, temporarily disable the therapy device from delivering the user-determined bolus quantity; and
a user interface in signal communication with the processor to output a warning of an impending hypoglycemic condition based on the determined previously monitored variation in the analyte level based on the monitored activity level of the user, the user interface configured to output the warning by at least displaying a therapy information relating to the user-determined bolus quantity and a prompt to receive a user input to confirm that the user-determined bolus quantity should be delivered, the therapy information and the prompt to receive the user input being overlaid on a real-time depiction of the analyte level;
wherein the processor is configured to, in response to the user input, re-enable the therapy device to deliver the user-determined bolus quantity.

US Pat. No. 10,478,104

GLUCOSE SENSING CONTACT LENS

MENICON CO., LTD., Nagoy...

13. A contact lens system, comprising:a contact lens, comprising:
a body having an eye-contacting surface configured to contact the surface of a user's eye;
a glucose sensing area operably encapsulated within the body, the glucose sensing area having a first state and a second state, wherein the glucose sensing area transitions between the first state and the second state as a concentration of glucose varies;
an optical sensor disposed between the eye contacting surface and the glucose sensing area;
a transmitter communicatively coupled to the optical sensor; and
a power supply coupled to the wireless transmitter; and
a wireless receiver, comprising:
a transceiver module operably coupled to an antenna, the transceiver module being configured to receive the data transmitted by the wireless transmitter;
a user interface module configured to receive input from the user;
a control module configured to control operational aspects of the contact lens system;
a memory module configured to receive and maintain computer-readable information;
a processor module configured to execute the computer-readable information stored within the memory module to operate the wireless receiver; and
a receiver power supply;
wherein the glucose sensing area prevents light from reaching the optical sensor while in the first state and allows light to pass through the glucose sensing area to expose the optical sensor to the light while in the second state.

US Pat. No. 10,478,103

APPARATUS, SYSTEMS, AND METHODS FOR DETERMINING AND DISPLAYING PRE-EVENT AND POST-EVENT ANALYTE CONCENTRATION LEVELS

Ascensia Diabetes Care Ho...

1. A hand-held device for identifying and displaying event readings, the hand-held device comprising:a processor;
a memory coupled to the processor;
software stored in the memory and executable by the processor; and
a display coupled to the processor and operable to present a graphical user interface (GUI), wherein the processor executing the software is operable to:
receive at the hand-held device from a measurement device a first analyte concentration reading and a second analyte concentration reading, both readings associated with a first event;
calculate a numerical delta between the first analyte concentration reading and the second analyte concentration reading for the first event with the hand-held device; and
display on the display via the GUI a time graph including a representation of the first event occurring and the numerical delta associated with the first event, wherein the numerical delta is displayed proximate to the representation of the occurrence of the first event to facilitate immediate visual evaluation of a relative magnitude of the numerical delta and an association with the first event, both indicating a significance of the first event.

US Pat. No. 10,478,099

SYSTEMS AND METHODS FOR DETERMINING AXIAL ORIENTATION AND LOCATION OF A USER'S WRIST

Apple Inc., Cupertino, C...

1. A strap for a wearable device, the strap comprising:an inner side and an outer side;
a plurality of strap holders configured to attach to a first edge and a second edge of a wearable device body; and
a plurality of capacitance sensors located on the inner side of the strap, the plurality of capacitance sensors configured to sense one or more changes in capacitance due to one or more forces of a user's wrist causing one or more changes in capacitance coupling, the plurality of capacitance sensors configured to generate one or more capacitance signals indicative of the one or more changes in capacitance coupling,
wherein the plurality of capacitance sensors is arranged as a grid of drive lines and sense lines.

US Pat. No. 10,478,083

EXTENDED WEAR AMBULATORY ELECTROCARDIOGRAPHY AND PHYSIOLOGICAL SENSOR MONITOR

Bardy Diagnostics, Inc., ...

1. An extended wear electrocardiography and physiological sensor monitor recorder, comprising:a sealed housing having a rounded isosceles trapezoid shape with substantially straight edge on a proximal end that is longer than a substantially straight edge on a distal end and configured to be removably secured into a receptacle on an electrode patch that comprises a battery electrically interfaced to a pair of electrical pads on the receptacle;
a set of electrical contacts that protrude from a bottom surface of the proximal end of the sealed housing and correspond with further electrical pads on the receptacle;
a patient feedback button located on the proximal end of the sealed housing on a surface opposite the electrical contacts on the bottom surface; and
electronic circuitry comprised within the sealed housing, comprising:
an electrographic front end circuit operable to sense electrocardiographic signals through electrocardiographic electrodes provided on the electrode patch;
a micro-controller electrically interfaced to the electrocardiographic front end circuit and operable to execute under micro-programmable control to sample the electrocardiographic signals sensed by the electrocardiographic front end circuit, to stage each electrocardiographic signal sample in a buffer, to compress each of the staged electrocardiographic signal samples, to further buffer each of the compressed electrocardiographic signal samples, and to write the buffered electrocardiographic signal samples to memory; and
a flash memory electrically interfaced with the micro-controller and operable to store the buffered samples of the electrocardiographic signals.

US Pat. No. 10,478,072

METHODS AND SYSTEM FOR CHARACTERIZING AN OBJECT

The General Hospital Corp...

1. A system for determining at least one characteristic of at least one anatomical structure, comprising:a first arrangement configured to forward at least one electromagnetic radiation having a time-varying intensity to the at least one anatomical structure and a further anatomical structure;
a detector second arrangement configured to detect at least one acoustic signal provided from each of the at least one anatomical structure and the further anatomical structure in response to the at least one electromagnetic radiation impacting the structures; and
a processing hardware third arrangement configured to (i) obtain calibration data from the acoustic signal from the further anatomical structure, based on at least one property of thereof; and (ii) determine the at least one characteristic of the at least one anatomical structure using the calibration data and the acoustic signal from the at least one anatomical structure;
wherein the at least one anatomical structure includes at least one of a pulmonary artery or a vein, and the further anatomical structure includes at least one of an aorta or an artery.

US Pat. No. 10,478,068

CAMERA DEVICE HAVING A PARABOLIC MIRROR SET BETWEEN DUAL CAMERAS AND METHOD FOR SHOOTING LIGHT HAVING AT LEAST TWO WAVELENGTH BANDS

Ricoh Company, Ltd., Tok...

1. A camera device comprising:a first camera containing a first lens for receiving light having a first wavelength band;
a second camera including a second lens for receiving light having a second wavelength band different from the first wavelength band, the second lens being disposed facing the first lens of the first camera; and
a parabolic mirror set between the first lens and the second lens, able to let the light having the first wavelength band penetrate therethrough, and at the same time, reflect the light having the second wavelength band,
wherein, the first camera is a non-fisheye camera; the first lens of the first camera is a non-fisheye lens; the second camera and the parabolic mirror form a catadioptric camera; and an aperture stop of the non-fisheye lens coincides with a focal point of the parabolic mirror.

US Pat. No. 10,478,063

MEASUREMENT DEVICE AND MEASUREMENT METHOD

HAMAMATSU PHOTONICS K.K.,...

1. A measurement apparatus for measuring a subject's eyelid position, comprising:a lighting device configured to irradiate band-like linear light extending across the subject's upper to lower eyelids;
an imaging device having an optical axis on a plane for which a plane including an extending bundle of rays of the light is rotated by a predetermined angle around an axis along a direction in which the band-like linear light extends across the subject's upper and lower eyelids; and
at least one processor having instructions stored in a non-transitory memory device, that, when executed by the at least one processor, cause the measurement apparatus to perform operations comprising:
obtaining height information indicating a height in the direction of irradiation of the light, based on a position of an optical image in an image imaged by the imaging device, and
measuring the eyelid position based on the height information,
wherein the height information is obtained based on the position of an optical image in a direction perpendicular to a direction in which the optical image extends,
wherein the imaging device is configured to capture the image including a first scattered light image of the subject's eyelid and a second scattered light image of the subject's sclera, and
the at least one processor causes the measurement apparatus to obtain height information indicating a height in the direction of irradiation of the light, based on a horizontal shift amount between a position of the first scattered light image and a position of the second scattered light image in the direction perpendicular to the direction in which the optical image extends.

US Pat. No. 10,478,057

TESTING APPARATUS AND TESTING METHOD

CHUKYO MEDICAL CO., INC.,...

1. A testing apparatus comprising:a display means that displays, in a background, a visual target varying in size and color for testing a color-related visual function of a subject, the visual target and the background being displayed such that a luminance of the background has a substantially same numerical value in luminance of the visual target;
a display control means that causes, in a state in which the subject is caused to gaze at a predefined point on the display means, the display means to display the visual target, while changing a size of the visual target, such that a threshold that is a size of the visual target that determines whether or not the subject can perceive the visual target is obtained in a peripheral region of a visual field center or at the visual field center; and
a obtaining means for obtaining at least one of the threshold in the size of the visual target that determines whether or not the subject can perceive the visual target as displayed in one of a predetermined set of colors over the background whose luminance value is substantially the same as the luminance of the visual target.

US Pat. No. 10,478,054

ENDOTRACHEAL TUBE WITH VISUALIZATION CAPABILITIES AND A LARYNGEAL MASK

1. A method for intubation of a patient comprising:positioning a laryngeal mask airway (LMA) in the patient, the LMA comprising a tube connected at a distal end thereof to a mask portion;
positioning an endotracheal tube in the LMA, the endotracheal tube sized and configured to pass through the tube of the LMA and comprising a visualization device at a distal end of the endotracheal tube, the visualization device structured to provide visual images of a distal space distal of the visualization device;
guiding the endotracheal tube through the LMA while visualizing the distal space;
prior to said guiding of said endotracheal tube through said LMA, connecting said visualization device to a display device; and
positioning the distal end of the endotracheal tube in the trachea of the patient; and
removing said LMA from the patient following said positioning while leaving said endotracheal tube positioned in the trachea.

US Pat. No. 10,478,053

ENDOSCOPE ILLUMINATION DEVICE

OLYMPUS CORPORATION, Tok...

1. An endoscope illumination device, comprising:a light source that outputs primary light;
a light guide that includes a first end face from which the primary light is radiated, and guides the primary light;
a light converter that is disposed to face the first end face, includes a second end face that the primary light enters, converts part of the primary light into secondary light; and
a holder that holds the light guide and the light converter so that an incident angle of the secondary light that is radiated from a point of intersection of the second end face and an optical axis of the light guide on the first end face and enters the first end face is equal to or larger than an acceptance angle (NA) of the light guide.

US Pat. No. 10,478,050

OPERATION DEVICE FOR INTO-BORE INTRODUCTION DEVICE, AND INTO-BORE INTRODUCTION DEVICE

OLYMPUS CORPORATION, Tok...

1. An endoscope comprising:a longitudinally elongated insertion section having a bending portion;
a grasping section connected to a proximal end of the insertion section, the grasping section adapted to be grasped by a hand of an operator for controlling the insertion section; and
a bending operation knob (1) having a rotational axis and being rotatably connected to a second surface of the grasping section, the rotational axis being transverse to the second surface, (2) comprising a plurality of protrusions protruding radially with respect to the rotational axis, (3) adapted to bend the bending portion of the insertion section, and (4) configured to be engaged by a thumb or one of fingers of the hand of the operator; wherein:
the grasping section includes a third surface adjacent and transverse to the second surface;
the third surface includes a projection (1) extending (a) outwardly from a portion of the third surface and (b) in a first direction transverse from the rotational axis of the bending operation knob and (2) forming a projection surface at its periphery in the first direction between an outer face of the projection and the portion of the third surface; and
the projection surface includes a curved section that (1) extends between a first section of the projection surface facing the insertion section and a second section of the projection surface facing the bending operation knob, (2) is configured to be contacted by the one of the fingers of the hand of the operator grasping the grasping section, and (3) has a curvature radius larger than a curvature radius of another curved section between the first section and a fourth surface of the grasping section.

US Pat. No. 10,478,049

ENDOSCOPE

OLYMPUS CORPORATION, Tok...

1. An endoscope comprising:a distal end rigid portion provided at a distal end of an insertion section, and including a through hole penetrating from inside to outside;
an elongated image pickup section provided inside the insertion section, a distal end of the image pickup section being fixed in a state of being inserted in the through hole;
a light guide fiber bundle provided inside the insertion section, and including distal end molded portions each having a distal end molded to have an outer shape that is specified in advance in relation to another component inside the insertion section, the distal end molded portions being inserted and fixed in the through hole, the light guide fiber bundle being formed as one bundle from a proximal end portion to a predetermined branched portion on a distal end side, and formed by being branched into a plurality of bundles on a distal end side with respect to the predetermined branched portion;
a plurality of first cover tubes made of expanded polytetrafluoroethylene, and respectively covering the plurality of bundles from the distal end molded portions to the predetermined branched portion; and
one second cover tube of a material other than the expanded polytetrafluoroethylene, covering the one bundle from the predetermined branched portion to the proximal end portion,
wherein the plurality of bundles of the light guide fiber bundle formed on the distal end side with respect to the predetermined branched portion are disposed while being compressed by the image pickup section through the first cover tubes in such a way that minor axes are 90% or less of a diameter of a case where each bundle of the plurality of bundles is formed to have a circular cross section.

US Pat. No. 10,478,044

TREATMENT INSTRUMENT FOR ENDOSCOPE AND ENDOSCOPE SYSTEM

OLYMPUS CORPORATION, Tok...

1. A treatment instrument for an endoscope used in combination with an endoscope, the treatment instrument comprising:a sheath having flexibility;
a treatment section disposed at a distal end of the sheath; and
a manipulation unit disposed at a proximal end of the sheath and configured to manipulate the treatment section,
wherein the sheath comprises:
a sheath main body having a lumen extending along a longitudinal axis of the sheath;
a transition section comprising an opening in communication with the lumen, the opening located at an intermediate section of the sheath main body;
a metal member fitted onto a distal portion of the sheath main body and the metal member covering a circumference of the sheath main body; and
a wire, wherein the wire extends through the lumen of the sheath main body, wherein a distal end of the wire is protruded from the opening of the transition section and the distal end of the wire is fixed to a proximal end portion of the metal member, and the wire configured to transmit rotational movement of a proximal end of the wire to the metal member; and
wherein the sheath main body comprises a first tube and a second tube, the second tube connected to a distal end of the first tube,
the first tube comprises the lumen and the opening,
the second tube is covered by the metal member,
the first tube has a first center,
the metal member has a second center, and
the first center is offset from the second center,
wherein the manipulation unit comprises:
a manipulation main body fixed to a proximal end of the sheath main body; and
a handle attached to a proximal end of the wire protruded from the manipulation main body and the handle being configured to input rotational torque to the wire,
wherein the wire comprises a plurality of individual wires, and
wherein the plurality of individual wires are only fixed to each other at each of a proximal end of the plurality of wires and a distal end of the plurality of wires.

US Pat. No. 10,478,043

STICKY CLEANER

KABUSHIKI KAISHA NITOMS, ...

9. A sticky cleaner used for removing organic dirt deposited on an article surface,the sticky cleaner comprising a dirt-collecting member that collects the organic dirt upon contact with the article surface, wherein
the dirt-collecting member has a pressure-sensitive adhesive in an area that comes in contact with the article surface, and
in the area, the dirt-collecting member exhibits a triolein absorption of 2 mg or greater per cm2 area of the pressure-sensitive adhesive.

US Pat. No. 10,478,035

CHARGING STAND FOR VACUUM CLEANER

JIANGSU MIDEA CLEANING AP...

16. The charging stand according to claim 1, wherein the pedal has a first end and a second end, and the first end of the pedal is pivotably connected to the body through a pivot shaft;an elastic resetting member is provided between the second end of the pedal and the body, and configured to normally push the pedal towards the first position;
wherein the pedal extends along a front-rear direction; the first end of the pedal is a rear end thereof, and the second end of the pedal is a front end thereof; and
wherein a side of the body adjacent to the second end of the pedal is provided with a position-limiting member, and the position-limiting member is located at a side of the pedal away from the elastic resetting member, wherein the elastic resetting member is configured as a spring.

US Pat. No. 10,478,034

CLEANING APPARATUS

SAMSUNG ELECTRONICS CO., ...

1. A cleaning apparatus, comprising:a cleaning apparatus body comprising a drive unit configured to generate a suction force;
a head unit through which air is introduced by the suction force;
a cleaning stick configured to extend from the head unit in a lengthwise direction; and
a dust collector comprising an inlet port, an outlet port spaced apart from the inlet port in the lengthwise direction, and a dust collecting flow path formed in the lengthwise direction from the inlet port to the outlet port,
wherein the dust collector comprises:
a cyclone unit comprising a cyclone space including the dust collecting flow path and configured to generate a cyclone stream from the air introduced through the head unit so that foreign matter is separated from the air that flows along the dust collecting flow path;
a dust collecting unit configured to communicate with the cyclone unit and comprising a dust collecting space to collect foreign matter from the cyclone unit;
a partition rib which partially partitions the dust collecting unit from the cyclone unit in a lengthwise direction of the dust collector;
a communication gap provided between an end of the partition rib and a discharge side of the dust collector through which the foreign matter separated from the air by the cyclone unit flows from the cyclone unit into the dust collecting unit; and
a prevention rib disposed in the dust collecting unit to be spaced apart from the communication gap a predetermined distance and disposed to face the communication gap to block foreign matter reversely flowing from the dust collecting unit into the cyclone unit,
wherein the cyclone unit comprises:
an inlet hole formed in a side of a tube extending from the inlet port to the inside of the cyclone space and formed so that air introduced from the inlet port is radially outwardly discharged from the tube, and
at least one cyclone generating rib formed spirally about the outer circumference of the tube to direct air introduced radially outward from the tube through the inlet hole to form a cyclone air stream,
wherein the cyclone space of the cyclone unit and the dust collecting space of the dust collecting unit are disposed inside a dust collector body, the dust collector body comprising an opening directly communicating with the cyclone space and the dust collecting space,
wherein a dust collector cover is disposed to open and close the opening of the dust collector body such that the cyclone space and the dust collecting space are accessible through the opening when the dust collector cover is open, and
wherein the prevention rib protrudes inwardly from the dust collector cover.

US Pat. No. 10,478,027

TOILET SEAT DEVICE AND TOILET DEVICE EQUIPPED THEREWITH

TOTO LTD., Kitakyushu-Sh...

1. A toilet seat device comprising:a toilet seat;
a toilet seat open/close sensor which senses whether the toilet seat is in an opened state or a closed state;
a Doppler sensor using radio waves; and
a controller,
the controller being capable of performing
a room-entering determination process of sensing approach of a user to the toilet seat based on a sensing signal outputted from the Doppler sensor,
a usage determination process of determining urination when it is sensed that the toilet seat is in the opened state, after the room-entering determination process, based on a sensing signal outputted by the toilet seat open/close sensor,
a leaving determination process of sensing that the user leaves from the toilet seat, after the use determination process, based on the sensing signal outputted by the Doppler sensor, and
an post-use operation process of outputting a flushing signal for flushing a bowl part of a toilet stool after the leaving determination process,
the controller performing the post-use operation process when it is sensed by the leaving determination process that the user leaves from the toilet seat after determining urination in the usage determination process,
the controller not performing the post-use operation process when it is sensed by the leaving determination process that the user leaves from the toilet seat after not determining urination in the usage determination process.

US Pat. No. 10,478,026

TOILET SPLASH GUARD APPARATUS WITH ENHANCED SANITATION

1. A splash guard apparatus for use in a bowl of a toilet to enhance sanitation, the splash guard apparatus disposed on water in the bowl of the toilet and configured to encapsulate solid waste and deflect fluid waste to minimize the transfer of contaminated water from exiting the bowl of the toilet, the splash guard apparatus comprising:a sheet assembly disposed on the water in the bowl of the toilet, the sheet assembly comprising an upper sheet and a lower sheet coupled together and configured to float on the water in the bowl, the upper sheet comprising a top surface, a bottom surface opposite the top surface and a plurality of slits disposed therethrough, the plurality of slits in the upper sheet of the sheet assembly being oriented parallel to each other, the lower sheet comprising a two-ply sheet coupled to the bottom surface of the upper sheet and in contact with the water in the bowl of the toilet, the lower sheet extending directly beneath the plurality of slits in the upper sheet;
wherein the lower sheet of the sheet assembly comprises a top surface with a first surface area and the top surface of the upper sheet comprises a second surface area, wherein the second surface area is greater than the first surface area, wherein the plurality of slits in the upper sheet of the sheet assembly is configured to deflect any fluid waste disposed thereon within the bowl of the toilet to minimize the contaminated water in the bowl from exiting the toilet, wherein the sheet assembly in the bowl is configured to encapsulate the solid waste disposed on the upper sheet, thereby minimizing splashes of the contaminated water from exiting the bowl of the toilet, wherein the sheet assembly is configured to permit the fluid waste disposed on the plurality of slits in the upper sheet to pass therethrough and generate bubbles between the upper and lower sheets, thereby enhancing flotation of the sheet assembly on the water in the bowl of the toilet.

US Pat. No. 10,478,023

FOLDED TOWEL DISPENSER WITH OVERFILL PREVENTION

Solaris Paper, Inc., Alp...

1. A dispenser for dispensing a preset amount of stacked sheets, comprising:a front cover moveably coupled with a housing back,
wherein the front cover and housing back define an interior storage space for storing the preset amount of stacked sheets,
wherein the front cover is configured to move between an open position and a closed position,
wherein the front cover and the housing back are pivotably coupled at a hinge,
wherein moving between the open position and the closed position comprises the front cover pivoting at the hinge,
wherein front cover has two opposing sides that at least partially overlap with two opposing sides of the housing back to define an overlapping area when the front cover is in the closed position,
wherein the hinge is disposed in the overlapping area,
wherein a top surface of the front cover covers a top surface of the housing back when the front cover is in the closed position, and
wherein the top surface of the front cover extends from a front surface of the dispenser to a rear surface of the dispenser when the front cover is in the closed position;
at least one dispensing opening disposed on the housing back for dispensing at least one of the stacked sheets;
a stacking surface for stacking the preset amount of stacked sheets;
an overfill prevention protrusion fixedly disposed from the housing back and extending into the interior storage space, the overfill prevention protrusion having a bottom surface;
a wall disposed between the overfill prevention protrusion and the stacking surface, wherein the wall intersects with the stacking surface to form a first angle and the wall intersects with the bottom surface of the overfill prevention protrusion to form an obtuse angle; and
wherein the overfill prevention protrusion remains at a fixed position and the bottom surface extends into the interior storage space in an amount sufficient to displace one or more stacked sheets exceeding the preset amount such that the one or more stacked sheets exceeding the preset amount physically obstruct the front cover from moving to the closed position.

US Pat. No. 10,478,017

COOKING APPARATUS UTILIZING GASEOUS FUEL

Rankam (China) Manufactur...

1. A cooking apparatus comprising:a plurality of chamber walls defining a chamber, the chamber including a plurality of chamber corners, a chamber bottom end, and a chamber top end; and
a gas burner including a burner tube located nearer the chamber bottom end than the chamber top end, the burner tube including:
a plurality of tube runs, each tube run including a run length extending substantially parallel with a respective chamber wall, each tube run including a continuous closed wall section along a majority of the run length such that the tube run has no holes anywhere in the tube run along the majority of the run length; and
a plurality of tube bends, each tube bend disposed between two respective tube runs and including a porous wall section of the burner tube.

US Pat. No. 10,478,013

COOKING APPLIANCE COMPRISING A LID EQUIPPED WITH A TUBE FOR ADDING FOOD

SEB S.A., Ecully (FR)

1. A Cooking appliance comprising a lid that closes, in a removable manner, a working container receiving a tool spun by a motor, the lid having a body equipped with a tube for adding food, the tube arranged in an off-center manner on the lid, the lid comprising a locking ring that can move by spinning on said body, and the locking ring can be in a closed position in which the locking ring holds the lid in a closed position on the working container, or an open position in which the lid can be lifted off of the working container, wherein the appliance comprises a drive hub with a lower end that mates, in a removable manner, with a driver arranged in the bottom of the working container and an upper end supporting a vegetable slicing disc, the body of the lid comprising a waste-prevention ring that comes to an edge of the vegetable slicing disc when the lid is in the closed position,wherein the waste prevention ring rises from a lower surface of a bottom wall of the lid and has a smaller diameter than a diameter of an interior skirt extending beneath an upper surface of the lid, and
wherein the interior skirt comprises a peripheral groove receiving an airtight gasket with a lip that comes to rest on one upper edge of the working container when the lid closes the working container.

US Pat. No. 10,478,012

METHOD OF MAKING A PLURALITY OF BONDED BLANK ASSEMBLIES

All-Clad Metalcrafters LL...

1. A method of making a plurality of bonded composite blank assemblies for the manufacture of cookware, comprising the steps of:(a) providing at least two blank assemblies for bonding, wherein each blank assembly comprises three discs of planar materials which are of stainless steel, aluminum and stainless steel, and a perforated template having a plurality of holes formed therein, said perforated template positioned on an outer surface of a stainless steel disc of each blank assembly;
(b) placing the at least two blank assemblies into a pressing fixture wherein each of the assemblies has a separation disc placed between adjacent assemblies to prevent bonding between adjacent assemblies;
(c) exerting an axial force on the assemblies by way of the pressing fixture;
(d) heating the assemblies while under pressure at a sufficient temperature and time to achieve a desired level of bonding between each of the discs in each of the blank assemblies;
(e) forming a plurality of spaced-apart bubbles along a surface of one of the stainless steel discs of each blank assembly during steps (c) and (d), wherein the bonding between the bubbles and the second disc is of a lesser degree than the bonding between the stainless steel and aluminum in areas intermediate said bubbles, whereby a coefficient of heat conductivity is greater in said intermediate areas than in said bubbles in each of the bonded blank assemblies;
(f) cooling the assemblies and removing each bonded assembly from the pressing fixture;
(g) separating each bonded blank assembly from an adjacent bonded blank assembly; and
(h) forming an item of cookware from each bonded blank assembly.

US Pat. No. 10,478,011

METHOD FOR PREPARING A FRESH BREWED COLD COFFEE BEVERAGE AND COFFEE MACHINE FOR CONDUCTING SUCH METHOD

1. A method for preparing a fresh brewed cold coffee beverage having a target temperature, comprising the steps of:a. filling a brewing means with a predetermined quantity of coffee powder;
b. brewing a coffee beverage having a temperature in excess of the target temperature by pushing a first stream of water and/or steam having a temperature in excess of the target temperature through said predetermined quantity of coffee powder in said brewing means;
c. reducing a temperature of said coffee beverage to a temperature at or above said target temperature by bringing a first stream of said coffee beverage having a temperature in excess of the target temperature in thermal contact with a first stream of water having a temperature sufficiently below said target temperature such that a heat exchange between said first stream of coffee beverage and said first stream of water reduces the temperature of said first stream of coffee beverage to said temperature at or above said target temperature, said first stream of coffee beverage and said first stream of water running through at least one heat exchanger; and
d. dispensing a fresh brewed coffee beverage at said temperature at or above said target temperature at a coffee outlet.

US Pat. No. 10,478,009

BEVERAGE INFUSION SYSTEM

1. A beverage infusion system comprising:an infusion chamber configured to hold an infusing material and to allow a beverage to flow through the infusion chamber past the infusing material such that the beverage is infused by the infusing material, wherein the infusion chamber is formed by:
an outer housing having a first end and a second end and openings formed at each end,
a first enclosure member configured to removably mount to the first end of the outer housing and to cover the opening located at the first end of the outer housing, and
a second enclosure member configured to removably mount to the second end of the outer housing and to cover the opening located at the second end of the outer housing;
a beverage inlet in fluid communication with the infusion chamber for carrying the beverage to the infusion chamber;
a beverage outlet in fluid communication with the infusion chamber for carrying the beverage to away from the infusion chamber;
a heat transfer probe inside the infusion chamber and positioned such that the beverage entering the infusion chamber via the beverage inlet and exiting via the beverage outlet flows past the heat transfer probe;
a coolant path operable for carrying a coolant through the heat transfer probe,
wherein, when the coolant is at a lower temperature than the beverage flowing through the infusion chamber, heat is carried away from the beverage and is transferred through the coolant probe to the coolant as the beverage flows past the coolant probe,
wherein the infusion chamber maintains pressure of the beverage passing through it, such that the pressure of the beverage at the beverage outlet is substantially equal to the pressure of the beverage at the beverage inlet, and
wherein the beverage infusion system further comprising a first filter configured to removably mount between the first enclosure member and the outer housing, such that the first filter covers the opening located at the first end of the outer housing and is positioned between the beverage inlet and the infusion chamber.

US Pat. No. 10,478,008

MACHINE FOR PREPARING BEVERAGES COMPRISING AN OPENING DISPOSITION AND PROCESS FOR PREPARING A BEVERAGE WITH ANTICIPATED OPENING

1. A beverage preparation machine (1) adapted for preparing beverages from single doses of at least one edible substance provided in a strip of linked single dose packages (2), said packages (2) comprising a support (21) carrying a plurality of single dose portions (22), each single dose portion comprising at least one first and one second package walls (23, 24) sealed so as to be substantially air tight, whereby said machine (1) comprises:at least one extraction device (3) adapted so that said at least one extraction device can collect one of said single dose packages (2) from said strip inside thereof,
an opening device (5) disposed upstream of said extraction device (3) along the supply direction of said strip, and adapted so as to provide a plurality of passageways (25) in at least one of said first and second package walls (23, 24) of said single dose portions (22),
wherein said opening device (5) comprises at least one opening part (51, 52) that presents a plurality of opening protrusions (53) disposed along a respective perimeter surface and adapted so as to provide said plurality of passageways (25), and
wherein said opening part (51, 52) is provided so that said opening part can be actuated in rotation around a substantially horizontal or vertical axis and disposed so that said opening part can produce said passageways (25).

US Pat. No. 10,478,007

ON-BOARD COFFEE PROCESSOR

1. An on-board coffee processor, comprising a boiling cup (11), a coffee bucket (13), a distill cup (19) and a lid (21); an upper end of the boiling cup (11) is connected with a lower end of the distill cup (19); the coffee bucket (13) is arranged at a rim of the boiling cup (11); the distill cup (19) is provided with a distill tube (20); a lower end of the distill tube (20) leads to the coffee bucket (13); a bottom of the distill cup (19) and an upper end of the tube (20) leads to an upper part of the distill cup (19); the lid (21) is connected to an upper end of the distill cup (19), a bottom of the boiling cup (11) is open, and an inner side at a lower end of the boiling cup is provided with a flange (30): the heating plate (8) is pressed against a bottom of the flange (30) by a heat-resistant bracket (5); a primary sealing ring (9) is arranged between the heating plate (8) and the flange (30); an outer circumference of the heat-resistant bracket (5) is connected with the inner side at the lower end of the boiling cup (11) by screw-thread fit, and a thermistor (7) is installed at a bottom of the heating plate (8).

US Pat. No. 10,478,005

STEAM GENERATING APPARATUS AND HEATING COOKER

SHARP KABUSHIKI KAISHA, ...

1. A steam generating apparatus comprising:a steam generator, the steam generator including a housing capable of storing water therein, and a heating unit for heating the housing so as to generate steam;
a water level measurement unit for measuring a water level in the housing;
a water supply unit for supplying water into the housing; and
a controller for controlling the heating unit and the water supply unit,
the controller being configured to
when a time during which that the measured water level does not exceed a threshold value continues for a first time, control the water supply unit to start water supply into the housing, and
when the time during which the measured water level does not exceed the threshold value continues for a second time longer than the first time, control the heating unit to stop heating of the housing;
wherein the controller is further configured to
when the measured water level exceeds the threshold value, and thereafter, when a time during which the measured water level exceeds the threshold value continues for a third time, control the heating unit to start heating of the housing, and
when the time during which the measured water level exceeds the threshold value continues for a fourth time longer than the third time, control the water supply unit to stop the water supply into the housing.

US Pat. No. 10,477,999

DOUBLE-LAYERED THERMAL INSULATION SLEEVE

1. A double-layered thermal insulation sleeve having a frusto-conical shape and being used to cover the outer surface of a cup to maintain a water and heat barrier, said sleeve comprising,a. a first thermal insulation layer, a second thermal insulation layer, and longitudinal fold lines,
b. said first thermal insulation layer having an upper channel edge and a lower channel edge;
c. said second thermal insulation layer having a back side, a non-slip and thermally insulative gripping surface, and an outer layer;
d. said first thermal insulation layer being a cup facing layer and being constructed from non-woven polyester fiber, said non-woven polyester fiber having a plurality of interior air channels being disposed on said first thermal insulation layer, said plurality of interior air channels having a plurality of bonding lines for connection to said second thermal insulation layer and forming a bonding site with said second thermal insulation layer, adhesive being used for fixedly attaching said bonding lines of said first thermal insulation layer to said back side of said second thermal insulation layer for permanent connection to said second thermal insulation layer and thereby creating said double-layered thermal insulation sleeve wherein said first thermal insulation layer is a cup facing layer and said second thermal insulation layer is said non-slip and thermally insulative gripping surface, said adhesive being placed between one of said bonding lines and said back side of said second thermal insulation layer in overlapping relationship, said plurality of interior air channels retaining said water and heat that is released from said cup, said fluid and said heat being released in an upward and downward direction in said plurality of interior air channels and from said upper channel edge and said lower channel edge, said upper channel edge and said lower channel edge being release points for said water and said heat from said first thermal insulation layer and thereby directing said heat and said fluids away from the hands of a user;
e. said outer layer of said second thermal insulation layer being constructed from embossed paper having outward facing bumps so as to provide said non-slip and thermally insulative gripping surface for said user, said second thermal insulation layer having poly-coating being applied thereon and wherein said poly-coating provides a moisture barrier by strengthening said second thermal insulation layer and prevents said liquid and said heat from permeating said second thermal insulation layer;
f. said longitudinal fold lines being arranged on said double-layered thermal insulation sleeve and allowing said double-layered thermal insulation sleeve to be folded into a flattened configuration along said longitudinal folds lines and stored for reuse.

US Pat. No. 10,477,997

CARBONATED BEVERAGE NUCLEATION ACCESSORY

1. A method comprising:placing a nucleation accessory into a beverage container, wherein the nucleation accessory includes a body that includes top and bottom surfaces and a rounded outer surface that extends around an axis between the top and the bottom surfaces, and wherein the body includes a bore extending completely through the body from the top surface to the bottom surface along the axis, and at least one recess in the rounded outer surface of the body, wherein the bore further includes at least one recess formed on a surface thereof facing the axis;
pouring a beer into the beverage container that includes the nucleation accessory, wherein a carbon dioxide gas is dissolved within the beer, and wherein the carbon dioxide gas attaches to the at least one recess in the outer surface of the body and to the at least one recess formed on the surface of the bore facing the axis; and
generating, by the at least one recess in the outer surface of the body and the at least one recess formed on the surface of the bore facing the axis, bubbles within the beer due to gas bubble nucleation to generate a head of foam.

US Pat. No. 10,477,982

BABY CRIB

Artsana S.P.A., (IT)

1. Baby crib comprising:an enclosure having side walls, including at least a first side wall and a second side wall, made of a flexible material and defining a space configured to receive a baby, the enclosure also having a bottom wall made of a flexible material, said side walls having top portions delimiting a top opening of the enclosure;
an upper frame configured to be attached to said enclosure,
a lower frame configured to support said bottom wall, said upper frame being spaced apart from said lower frame along a longitudinal direction,
support members attached to said upper frame and said lower frame, said support members being configured to rest on a ground surface and being spaced apart along a transverse direction perpendicular to said longitudinal direction,
wherein
said upper frame comprises a first part firmly attached to said support members and a second part, said first part being attached to a first top portion of the first side wall of the enclosure, said second part being attached to a second top portion of the second side wall of the enclosure,
said second part is pivotally coupled with said support members around a pivot axis to move reversibly from a first position to a second position to move said second part relative to said first part, said pivot axis being arranged in a longitudinal position between the first part and the lower frame, and
said second part is U shaped and comprises two opposed sections coupled at opposite sides to the support members and an elongated section connecting the two opposed sections, said opposed sections comprising first portions laying on a same plane with the elongated section and second portions extending perpendicularly to the first portions and being joined with the first portions.

US Pat. No. 10,477,975

MATTRESS WITH COMBINATION OF PRESSURE REDISTRIBUTION AND INTERNAL AIR FLOW GUIDES

FXI, Inc., Media, PA (US...

1. A body support system, comprising:a base defining a length and a width and a longitudinal axis;
a first breathing layer disposed over the base, said first breathing layer defining multiple rows of cellular polymer material, wherein cellular polymer material forming at least two rows has air permeability of at least 5 ft3/ft2/min, with said at least two rows spaced apart from one another by a row of a different cellular polymer material having an air permeability below 5 ft3/ft2/min;
a second breathing layer disposed over the first breathing layer, said second breathing layer defining multiple rows of cellular polymer material, wherein cellular polymer material forming at least two rows has air permeability of at least 5 ft3/ft2/min, with said at least two rows spaced apart from one another by a row of a different cellular polymer material having an air permeability below 5 ft3/ft2/min, and wherein a first one of the at least two rows of said second breathing layer is positioned over and in staggered relation to a first row of the at least two rows of the first breathing layer to define a first air flow path through the first row of the second breathing layer and the first row of the first breathing layer that is disposed at an angle offset from vertical, and wherein a second row of the at least two rows of said second breathing layer is positioned over and in staggered relation to a second row of the at least two rows of the first breathing layer to define a second air flow path through the second row of the second breathing layer and the second row of the first breathing layer that is disposed at an angle offset from vertical;
a porous bridge having air permeability of at least 5 ft3/ft2/min positioned in the base and in contact with the first breathing layer; and
at least one air flow unit coupled to the first breathing layer by the porous bridge for drawing air and/or moisture vapor through the first breathing layer and the second breathing layer.

US Pat. No. 10,477,973

ERGONOMIC CHAIR

1. An improved ergonomic chair comprising:a backrest frame comprising a central support, an upper edge, a lower edge, two side edges with each side edge comprising upper, central and lower side portions; and
a mesh material attached to the frame along the upper edge, lower edge and side edges;
wherein the central support of the frame extends from the lower edge upwardly to connect to each side edge at the central side portion, an opening is formed on each side of the central support between the central support and the lower side portions of the side edges, and a third opening is formed between the central support and the upper edge;
wherein the lower side portions are bowed inwardly away from the central support and the width of the frame between the lower side portions is larger than the width between the central side portions;
wherein the upper side portions and the upper edge are projected forward, relative to the central side portions;
wherein the width of the frame is wider between the upper side portions than the width between the central side portions; and
wherein a portion of the mesh material at the level of the central side portions is projected outwardly forward relative to the central side portions of the frame.

US Pat. No. 10,477,968

INTERCHANGEABLE CUSTOMIZABLE HARDWARE FOR PULL MECHANISMS

KNOCKOUT KNOBS LLC, New ...

1. A pull assembly comprising:a base having a first portion that defines a first end and a stem that defines a second end, wherein the first portion includes at least one locking slot that has an arcuate shape; and
an insert that has a first face that faces outward and includes decorative indicia and a second face that faces inwards and includes at least one locking pin, the locking pin being configured to be freely received within the locking slot and is movable to a locked position and the insert is securely coupled to the base by a friction fit being formed between the insert and the base;
wherein the at least one locking slot has a first end and an opposing second end, wherein a width of the locking slot varies along the length thereof from the first end to the second end, wherein the at least one locking pin is initially received within the second end which has an enlarged width relative to the first end and in the locked position, the at least one locking pin is disposed at or proximate to the first end of the locking slot.

US Pat. No. 10,477,964

LOCKER SEAT ASSEMBLY

1. A locker, comprising:a pair of upstanding side walls;
a seat assembly disposed between the side walls, the seat assembly comprising:
a generally horizontal seat bench; and
a multi-piece seatback comprising:
a lower seatback having an upper edge and being connected to and movable about a hinge between an open position and a closed position; and
an upper seatback having a lower edge and being connected to and movable about a hinge between an open position and a closed position;
wherein the lower edge of the upper seatback and the upper edge of the lower seatback are adjacent to each other when the upper seatback and the lower seatback are in the closed positions; and
wherein the lower seatback is configured to pivot downward toward the seat bench and the upper seatback is configured to move upward away from the seat bench as the multi-piece seatback transitions from the closed position to the open position.

US Pat. No. 10,477,954

ORAL CARE DEVICE

Olson IP Technologies, In...

1. An oral care device comprising:a body;
an oral care implement connected to the body;
an oral care byproduct cavity of the body;
an inlet in communication with the oral care byproduct cavity and permitting oral care byproducts to pass into the oral care byproduct cavity; and
an absorbent material in the oral care byproduct cavity.

US Pat. No. 10,477,953

TOOTH CLEANING DEVICES AND PROCESSES FOR USING SAME

1. A process for using a tooth cleaning device, comprising:(a) providing the tooth cleaning device, wherein the device comprises a substantially planar base having opposing first and second sides;
a grip member extending proximally from the first side;
a plurality of first bristles attached to and distally extending from the second side;
optionally a plurality of second bristles attached to and distally extending from the second side; and
an oral care composition disposed within a housing or on the first bristles;
(b) gripping the grip member;
(c) dispensing the oral care composition such that the oral care composition is released onto the first bristles; and
(d) activating the oral care composition with the user's saliva and brushing the user's teeth with the first bristles.

US Pat. No. 10,477,949

BELT KEEPER

1. A belt clip system for releasably securing a duty belt to a dress belt overlaid and circumscribed thereby, said system comprising:a dress belt clip for attaching to said dress belt and having a magnet engagement portion overlaying and springedly connected to an inside wall, said magnet engagement portion having a magnet engagement wall with a first trap wall extending therefrom in a direction away from said inside wall, said magnet engagement portion having a second trap wall extending outwardly in a direction away from said inside wall, said magnet engagement wall and said trap walls cooperating to form an effective pocket, said inside wall having a belt stop wall extending from a terminal edge of said inside wall towards said magnet engagement portion;
a duty belt clip for attaching to said duty belt and having a magnet retaining portion overlaying and springedly connected to an outside wall, said magnet retaining portion having a permanent magnet affixed thereto at a magnet retention aperture, said permanent magnet facing away from said outside wall, said outside wall extending beyond said magnet retaining portion to a retainer hook, said retainer hook having an overhanging portion extending over said outside wall and terminating at a hook edge, said hook edge spaced from said magnet retention aperture by a first distance;
a retention clip pivotably affixed with respect to said magnet retaining portion between a locked and an unlocked position, said retention clip having a terminal edge spaced from a retention aperture by a second distance, when said retention clip is in said locked position, said terminal edge located between said outside wall and said overhanging portion; and
said duty belt clip releasably held to said dress belt clip when said permanent magnet on said duty belt clip contacts said magnet engagement wall and resides in said effective pocket.

US Pat. No. 10,477,948

REMOVABLE DEVICE FOR MOUNTING ACCESSORIES TO A HELMET

Task Racing LLC, Plymout...

1. An apparatus comprising:a helmet mounting component including an internal surface and an opposed exterior surface configured to adapt to a curvature of a helmet via an attachment portion, said helmet mounting component having angularly defined slots and curved receiving grooves;
a cradle comprising an upper exterior portion configured to receive an accessory, a lower exterior portion including a first plurality of relief slots and a second plurality of relief slots, at least one friction receiving portion, an interior surface adaptable to a shape of the accessory, an accessory securement element, a utility hole, a cord relief portion and non-linear rails to integrate and removably couple said cradle to said helmet mounting component via said non-linear rails positioned within the curved receiving grooves, wherein each relief slot of the first plurality of relief slots has a length greater than each relief slot of the second plurality of relief slots; and
an integrated friction element disposed between said helmet mounting component and said cradle that is configured to adjust position of the cradle relative to the helmet mounting component.

US Pat. No. 10,477,944

HEATING SYSTEM FOR A COSMETIC MASK

ELC MANAGEMENT, LLC, Mel...

1. A kit comprising:A base, multiple heating packettes reposed in the base, and a power cable, wherein:
each heating packette comprises:
top and bottom panels having:
perimeter portions that are bonded together to form a reservoir between the two panels, the reservoir measuring 25 mm-150 mm by 25 mm-150 mm;
a fabric that is impregnated with a cosmetic or personal care preparation disposed in the reservoir; and
at least one heating element that is in physical contact with at least one of the panels, wherein the heating element:
is a continuous resistive electric path that has a positive terminal and a negative terminal located near the perimeter portion of that panel on which the heating element is located;
has a resistance between 1? and 15?, and is able to convert electrical energy into heat at a rate of 5 watts to 10 watts; and
comprises a positive thermal coefficient ink that is printed onto the exterior surface of the top or bottom panel; and
the power cable has two metal clips at one end, and a USB-type connector at the other end for connecting a power source to the positive and negative terminals of one of the heating packettes, wherein the voltage of the power source is in the range of 1.5 V to 12 V;
wherein the heating packette is configured with an integrated circuit that has programmed instructions, and the USB-type power cable is able to transfer data to and from the packette.

US Pat. No. 10,477,931

SUNSHADE AND METHOD OF PREPARING A CANOPY

1. A sunshade comprising:a support frame; and
a canopy connected to said support frame and including a light-transmissible fabric sheet of undyed yarns that has opposite inner and outer surfaces, an ink layer directly formed on one of said inner and outer surfaces of said light-transmissible fabric sheet using dye-sublimation printing techniques, and an opaque enamel coating coated on the other of said inner and outer surfaces of said light-transmissible fabric sheet;
wherein said undyed yarns are woven and cross one another to form fabric pores thereamong, said opaque enamel coating filling said fabric pores; and
wherein said ink layer includes a pigment and is free of an adhesive resin.

US Pat. No. 10,477,929

MODULAR ACCESSORY APPARATUS

REGAL JEWELRY MANUFACTURE...

1. A modular accessory apparatus, comprising:a body component, having a first end and a second end, the body component having a curvature such that a gap forms between the first end and the second end along the direction of extension of the curvature, and the first end has a connector; and
a housing component for modularly coupling to the connector, wherein the housing component comprises:
a housing body having an opening;
a coupler component disposed in the housing body; and
a gateway block disposed in the opening, and the gateway block has a through-hole corresponding to the coupler component;
wherein the connector passes through the through-hole and engages with the coupler component, and the through-hole of the gateway block limits a displacement movement of the connector to the direction through the through-hole;
wherein the coupler component is formed substantially in the shape of an ohm symbol (), wherein the coupler component has a coupler base, two guidance components respectively connected to the coupler base, and a coupler opening formed between the two guidance components; the coupler opening corresponds to the opening of the housing body and the through-hole of the gateway block.

US Pat. No. 10,477,926

SAFETY BELT LATCH STRUCTURE

Taiwan Racing Products Co...

1. A safety belt latch structure comprising:a base;
a locking hook member mounted on the base; and
a positioning shaft mounted on the base;
wherein:
the base has a front end provided with a mounting section, and a rear end provided with a belt passing section;
the mounting section of the base is provided with a receiving recess, a connecting seat, and a locking seat;
the locking hook member is mounted on the mounting section of the base, and received in the receiving recess of the mounting section;
the locking hook member has a first end provided with a hooked portion and a second end provided with an abutting portion;
the locking hook member is provided with a shaft hole mounted on the connecting seat of the base, and a first locking portion mounted on the locking seat of the base;
the positioning shaft is mounted on the connecting seat of the base and extends through the shaft hole of the locking hook member;
the locking seat of the base is formed with a through hole;
the through hole of the locking seat has an end provided with a stop wall which extends inward;
the safety belt latch structure further comprises a press switch mounted on the locking seat of the base;
the press switch includes an elongate push knob mounted in the through hole of the locking seat and extending through the receiving recess of the mounting section, a covering member secured to the locking seat of the base, and an elastic member mounted in the through hole of the locking seat and biased between the push knob and the covering member;
the push knob has a first end provided with a pressing portion protruding from the through hole of the locking seat, and a second end provided with a resting portion resting on the elastic member;
the push knob is provided with a depression and a second locking portion; and
the first locking portion of the locking hook member is locked with the second locking portion of the push knob and is received in the depression of the push knob.

US Pat. No. 10,477,922

GUIDES AND COMPONENTS FOR CLOSURE SYSTEMS AND METHODS THEREFOR

Boa Technology Inc., Den...

1. An elongate tension member guide that is coupleable with footwear and that is configured to direct or route a tension member about a path of the footwear, the tension member guide comprising:a main body having a longitudinal length and a lateral width, the main body being folded along the longitudinal length, the main body including:
a first edge that is coupleable with the footwear under an upper of the footwear so that the main body is positioned along an eyestay of the footwear;
a second edge that is positioned on an opposite side of the main body from the first edge; and
a plurality of slits or incisions in the main body through the second edge, the plurality of slits or incisions defining a plurality of loops or channels within which the tension member is insertable;
wherein each loop or channel is defined between a pair of slits or incisions;
wherein each loop or channel has a base portion that connects the loop or channel with the main body and a middle portion that is aligned with the second edge; and
wherein the middle portion of each loop or channel is wider than the base portion such that the middle portion protrudes or extends longitudinally outward from the base portion.

US Pat. No. 10,477,921

AIR BLADDER BOOT FITTING DEVICE

6. An air bladder boot fitting device comprising:a boot having a sole, an upper coupled to and extending upwardly from said sole, said upper including a shaft section extending downwardly from an open upper edge;
a bladder coupled to said upper, said bladder being positioned within an interior of said boot, said bladder extending along said shaft section wherein said bladder is configured for securing a foot of the user within said boot when said bladder is inflated, said bladder extending partially around a circumference of an interior surface of said shaft section wherein a strip of said shaft section is exposed within said interior of said boot, said strip extending upwardly from a heel of said boot to said open upper edge;
a bulb valve coupled to said bladder such that said bulb valve is configured for inflating said bladder, said bulb valve being positioned outside of said boot, said bulb valve being coupled to said bladder aligned with a front quarter of said shaft section of said upper and extending from said open upper edge;
a release valve being in fluid communication with said bladder wherein said bladder is deflated by opening of said release valve;
a latch coupled to an exterior surface of said boot proximate said open upper edge wherein said latch is configured for securing said shaft section around a calf of the user; and
an exterior of said sole and said upper being rubberized wherein said boot is waterproof and configured for use while pouring concrete; and
wherein said strip is configured to correspond to and align with the achilles tendon of the user and bears the friction of the user's heel as the boot is put on or taken off.

US Pat. No. 10,477,920

ARTICLE OF FOOTWEAR UPPER INCORPORATING A TEXTILE COMPONENT WITH TENSILE ELEMENTS

NIKE, Inc., Beaverton, O...

1. An upper comprising:a heel region, a first side, and a second side, the upper further including a knitted component that at least partially defines the heel region, the first side, and the second side of the upper; and
a tensile element that is inlaid within knit courses of the knitted component,
wherein the tensile element defines a first segment disposed on the first side of the upper;
wherein the first segment of the tensile element is configured to attach a securement device to the knitted component on the first side of the upper;
wherein the tensile element further includes a second segment that is disposed proximate a lower portion of the upper on the second side;
wherein the second segment is fixed relative to the lower portion of the upper on the second side;
wherein the tensile element further includes an intermediate segment that extends continuously from the first segment, across the heel region, to the second segment; and
wherein the tensile element is configured to transfer at least a portion of an input force applied to the first side of the upper across the heel region, to the lower portion of the upper on the second side.

US Pat. No. 10,477,916

SOLE STRUCTURE FOR AN ARTICLE OF FOOTWEAR WITH FIRST AND SECOND MIDSOLE BODIES

NIKE, Inc., Beaverton, O...

1. A sole structure for an article of footwear, comprising:a first midsole body defining a ground-facing surface and a foot-facing surface opposite the ground-facing surface, wherein the first midsole body includes a first midsole material, and the first midsole material has a first hardness; and
a second midsole body extending through the first midsole body such that the second midsole body extends beyond the ground-facing surface of the first midsole body, wherein the second midsole body includes a second midsole material, the second midsole material has a second hardness, and the first hardness is greater than the second hardness;
wherein the second midsole body includes a midsole heel portion, a midsole forefoot portion, and a midsole midfoot portion between the midsole heel portion and the midsole forefoot portion;
wherein the midsole heel portion has a camber; and
wherein the second midsole body is tapered along the midsole midfoot portion and the midsole forefoot portion such that a width of the second midsole body decreases from the midsole midfoot portion toward the midsole forefoot portion.

US Pat. No. 10,477,915

DEVICE FOR HIGH-HEELED SHOES AND METHOD OF CONSTRUCTING A HIGH-HEELED SHOE

HBN SHOE, LLC, Salem, NH...

1. A device for insertion into a heeled shoe, the device comprising:a rear region having a foot supporting surface configured to underlie a wearer's calcaneal tuberosities;
a forward region having a foot supporting surface configured to underlie at least a portion of the shafts of the wearer's metatarsals;
a lateral side; and
a distal side;
wherein the rear region foot supporting surface includes first and second elongated ellipsoid-shaped depressed region, the first elongated ellipsoid-shaped depressed region being 2-5 times larger in area and deeper than the second elongated ellipsoid-shaped region to underlie respectively the lateral and medial tuberositites of the wearer's calcaneus;
wherein the first elongated ellipsoid-shaped depressed region has an elongate axis running in a rear-to-forward direction of the device and skewed in a direction towards the medial side of the device;
wherein the second elongated ellipsoid-shaped depressed region has an elongate axis running in a rear-to-forward direction of the device and skewed in a direction towards the lateral side of the device;
wherein the second elongated ellipsoid-shaped region is shorter in length than the first elongated ellipsoid-shaped region; and
wherein an upper surface of said rear region has a raised portion configured to underlie an area of the wearer's calcaneus forward of the wearer's lateral and medial tuberosities; and an upper surface of the forward region is configured to underlie at least a portion of the shafts of the wearer's metatarsals, the upper surface of said forward region having a generally rounded or ellipsoid shape raised portion which rises to an apex configured to underlie the shafts of the wearer's second and third metatarsals.

US Pat. No. 10,477,913

OUTWARD ROTATING GOLF SHOES

1. A shoe sole with a pattern configured for one-way rotation in one direction and exceptional traction for the other direction comprising:the pattern having:
a one directional rotation pattern including one cone shaped spike at a center point or axis of said one directional rotation; one or more circular members or blades concavely curved around the center cone shaped spike forming a circle such that any point on a particular circle member or blade will be approximately equal distance from the center cone spike to any other point on the same said circle member or blade: and a one-way directional rotation pattern of one-way guide blades having two different functioning and designed ends, said one-way rotation pattern of one-way guide blades including more than one row of substantially parallel and concavely axial curved one-way guide blades around the center point so that any point on the one-way guide blade will be approximately equal distance from the center point to any other point on the same one-way guide blade, each of the rows exclusively including one-way guide blades, each one-way blade with a slide end on a same end, facing an outside edge of the shoe sole and a catch or stop end on the other end of the one-way guide blade facing an inside edge of the shoe sole, each of the one-way guide blades being an elongated member extending partially from the inside edge of the shoe sole towards the outside edge of the shoe sole in an axial direction concavely curved about the center point of the cone shaped spike, each of the one-way guide blades having:
a top portion that is flat or squared,
the slide end on one end of the one-way guide blade including a gradually protruding or slanted portion gently extending from the shoe sole to the top portion of the one-way guide blade in a gradual or sloped direction forming an inclined plane from the slide end from the shoe sole to a part of the one-way guide blade furthest from the shoe sole or top portion of the one-way guide blade when the shoe is upside down, whereby the one-way guide blade is configured to allow the one-way rotation toward the slide end of the one-way guide blade that gradually protrudes from the shoe sole at an extremely obtuse, almost 180 degree angle, all of the gradually protruding or slanted portion of said one-way guide blades are positioned facing the outside edge of the sole: and the stop or catch end of the one-way guide blades including a barb or sharp terminal end, said barb or sharp terminal end extending from the shoe sole to the top portion in an inverse angle or sharp direction resembling a shape of the number seven when the shoe is upside down, the barb or sharp terminal end is angled downwards toward the shoe sole where an exterior of the barb or sharp terminal end forms an acute angle to the shoe sole, the acute angle transitioning from the part of the one-way guide blade furthest from the shoe sole or top portion of the one-way guide blade when the shoe is upside down, whereby the one-way guide blade is configured to restrict movement opposite one-way rotation toward the stop or catch end of the one-way guide blade that sharply or inversely protrudes from the shoe sole forming the barb or sharp terminal end extending from the shoe sole at the acute angle; whereby the shoe sole is configured to rotate in one direction about said center point of the cone shaped spike, and catch or stop in an opposite direction wherein all of the barb or sharp terminal end of the one-way guide blades will be positioned facing the same direction toward the inside edge of the sole.

US Pat. No. 10,477,909

HELMET FOR IMPACT PROTECTION

Bauer Hockey, LLC, Exete...

1. A helmet for protecting a head of a wearer, the helmet comprising:an outer shell; and
inner padding connected to the outer shell, the inner padding configured to be disposed between the outer shell and the wearer's head, the inner padding comprising a plurality of pads separate from one another, each pad comprising a plurality of padding layers that overlap one another and are arranged such that adjacent ones of the padding layers of the pad are movable relative to one another in response to a rotational impact on the outer shell, wherein:
the pad comprises a low-friction interface between the adjacent ones of the padding layers of the pad to facilitate movement of the adjacent ones of the padding layers of the pad relative to one another;
the low-friction interface of the pad is between a first one of the padding layers of the pad and a second one of the padding layers of the pad; and
the low-friction interface of the pad is configured such that a coefficient of friction between the first one of the padding layers of the pad and the second one of the padding layers of the pad is lower than a coefficient of friction between a shock-absorbing material of the first one of the padding layers of the pad and a shock-absorbing material of the second one of the padding layers of the pad.

US Pat. No. 10,477,907

SKIN CARE MASK GLOVE AND MASK SOCK

VOESH CORPORATION, Plain...

1. A skin care mask sock, comprising:a sock portion having:
a first opening section having a first opening configured for receiving a foot and a first tightening strap for tightening said first opening section after the foot is inserted;
a foot section; and
a toe section having a first perforated line and a first removable toe tip portion, said first perforated line configured to extend across a user's toes such that when the first removable toe tip portion is removed along the first perforated line, all of the user's toes are exposed,
wherein said sock portion includes a first outer layer, a first inner layer and a layer of a first skin care product; and
a leg extension portion having:
a second opening section having a second opening configured for receiving the foot and a second tightening strap for tightening said second opening section after the foot is inserted;
a leg section; and
an ankle section coupled to said first opening section and having a third opening and a third tightening strap for tightening said ankle section after the foot is inserted,
wherein said first opening section is coupled to said ankle section via a middle section having a second perforated line; and
wherein said leg extension portion includes a second outer layer, a second inner layer and a layer of a second skin care product.

US Pat. No. 10,477,898

ELECTRONIC CIGARETTE

FONTEM HOLDINGS 1 B.V., ...

1. A vaporizing device, comprising:a housing;
liquid stored in the housing;
at least one air inlet for allowing air to flow into the housing;
a hollow electric heater coil around a first axis parallel to a longitudinal axis of the device, and the hollow electric heater coil surrounded by the liquid;
a channel extending through the hollow electric heater coil;
with the channel and an inhalation port forming an airflow path within the housing, and with the channel providing a continuous open passageway through the hollow electric heater coil to the inhalation port, with inhalation on the device causing air to flow through the hollow electric heater coil; and
an annular liquid permeating component around the first axis and sleeved on the hollow electric heater coil, with the hollow electric heater coil contacting an inner cylindrical surface of the liquid permeating component along substantially an entire length of the hollow electric heater coil, and with the liquid stored in the housing permeating through the liquid permeating component to the hollow electric heater coil for vaporization.

US Pat. No. 10,477,894

INDUCTIVE HEATING DEVICE FOR HEATING AN AEROSOL-FORMING SUBSTRATE

Philip Morris Products S....

1. Inductive heating device for heating an aerosol-forming substrate comprising a susceptor, the inductive heating device comprising:a device housing,
a DC power source having a DC supply voltage,
a power supply electronics configured to operate at high frequency in the range of 1 MHz to 30 MHz, the power supply electronics comprising a DC/AC inverter connected to the DC power source, the DC/AC inverter including a power amplifier including a transistor switch, a transistor switch driver circuit, and an LC load network configured to operate at low ohmic load, wherein the LC load network comprises a shunt capacitor and a series connection of a capacitor and an inductor having an ohmic resistance, and
a cavity arranged in the device housing, the cavity having an internal surface shaped to be capable of accommodating at least a portion of the aerosol-forming substrate, the cavity and the inductor of the LC load network being arranged relative to one another such that upon accommodation of the portion of the aerosol-forming substrate in the cavity the inductor of the LC load network is inductively coupled to the susceptor of the aerosol-forming substrate during operation.

US Pat. No. 10,477,893

ELECTRONIC VAPOR PROVISION DEVICE

NICOVENTURES HOLDINGS LIM...

1. An electronic vapor provision device comprising:a body including a power cell and a processor, wherein the processor has a normal operation mode and a lower power sleep mode; and
a mouthpiece comprising a liquid store and a vaporizer, wherein the vaporizer is in fluid communication with the liquid store using a wick to transport liquid from the liquid store to the vaporizer for vaporization,
wherein the mouthpiece is connectable to the body in a co-axial manner, and
wherein the processor is configured to:
periodically check, during both the normal operation mode and the lower power sleep mode, whether the mouthpiece is connected to or disconnected from the body,
detect when the device has been inactive for a predetermined inactive time while the mouthpiece is connected to the body,
in response to such a detection of the device being inactive, and while the mouthpiece is connected to the body, transition from the normal operation mode into the lower power sleep mode,
detect, based on the periodic checking, and after the transition from the normal operation mode to the lower power sleep mode, that the mouthpiece has been disconnected from the body,
detect, based on the periodic checking, after the mouthpiece has been disconnected from the body, that the mouthpiece has been reconnected to the body, and
in response to such a detection of the disconnection and then reconnection, transition from the lower power sleep mode back into the normal operation mode.

US Pat. No. 10,477,892

APPARATUS FOR SECURING TO THE TOP OF A BOTTLE OR CANISTER FOR PROVIDING A SMOKING ASSEMBLY

1. A method for smoking leaves comprising:filling a vessel with an open top with a volume with water or other liquid so that there is a remaining air volume within the vessel;
engaging a smoking apparatus comprising a straw element and a bowl with the open top of the vessel;
inserting a flame-resistant straw into the straw element and into the interior of the vessel;
positioning the straw relative to the straw element to ensure that the top end of the straw may be placed on the lips of a user without the face of the user coming into close contact with the bowl, such that any flame or heated material within the bowl is at a safe distance from the user's face;
placing crushed plant leaves into the bowl for lighting with a fire instigating device; and
smoking the crushed plant leaves by lighting the plant leaves with a fire instigation device, wherein the user places his or her lips on the top end of the straw, wherein the smoke from the burnt leaves travels down in to the open air chamber of the vessel and up through the straw while being cooled by the water or other liquid and the ambient temperature of the vessel, wherein excess debris from the burnt leaves is filtered down into the water portion of the vessel by falling directly through apertures located on the bottom of the smoking apparatus, and wherein cooled and filtered smoke from the burnt leaves is substantially contained within the air volume within the vessel.

US Pat. No. 10,477,889

SYSTEM, APPARATUS AND METHODS FOR A PARTICULATE FILTRATION

1. A glassware apparatus comprising:a water pipe of single-piece construction having a mouth piece in fluid communication with a compact chamber of the water pipe,
the water pipe comprising:
a cylinder inbuilt within the water pipe, wherein the cylinder comprises a flat surface on
a first end and an open duct on a second end, the cylinder formed concentrically within
a circumference of the water pipe, each the water pipe and the cylinder having a center in planar alignment;
an aperture in fluid communication with a smoke inlet tube, the smoke inlet tube having a volatizing chamber mount, the volatizing chamber mount disposed in a plane lower than a plane of the mouth piece;
a secondary wall of the cylinder disposed in parallel with a primary wall of the water pipe defining the compact chamber between the primary wall and the secondary wall;
a fritted porous glass filter disposed within a void between an underside of the flat surface of the first end of the cylinder and a base of the water pipe, the base disposed at a bottom end of the water pipe opposite the mouth piece; and
a liquid disposed between the fritted porous glass filter and the base of the water pipe;
wherein the glassware apparatus further comprises a volatizing chamber removably coupled to the water pipe via the volatizing chamber mount such that the volatizing chamber is in fluid communication with the volatizing chamber mount.

US Pat. No. 10,477,884

APPARATUS FOR EGG SEPARATION

1. An egg separating apparatus comprising:a) a substantially square support frame member defining an inner opening;
b) a plurality of rod members that are attachably connected to said support frame member within said opening, wherein said rod members comprise a substantially semi-circular configuration with a substantially curved and rounded top surface in order to provide a substantially smooth exterior and thus prevent an egg yolk from breaking upon contact with said top surface; and
c) a plurality of vents that are formed between said rod members, wherein said vents comprise a width distance that is relatively wide enough to allow at least one egg white to pass through said vents, but that is relatively narrow enough to prevent at least one egg yolk from passing through said vents.

US Pat. No. 10,477,879

MACHINE FOR MAKING LIQUID OR SEMI-LIQUID FOOD PRODUCTS AND METHOD OF OPERATING THE MACHINE

1. A machine for making liquid or semi-liquid food products, comprising:a processing chamber for processing a basic mixture and including a stirrer and a thermal treatment system for the basic mixture, operating in conjunction with one another to convert the basic mixture into a liquid or semi-liquid product;
a dispensing device including a dispensing nozzle connected to the processing chamber to deliver the liquid or semi-liquid product,
a support having a housing seat for housing a receiving container;
a movement mechanism suitable for vertically moving the support between a vertical position away from the dispensing nozzle and a vertical position close to the dispensing nozzle;
a rotation mechanism suitable for rotating the housing seat about a vertical axis;
wherein the movement mechanism comprises a slide, which the support is mechanically connected to, and at least one guide for vertically guiding the slide;
wherein the movement mechanism comprises: a cantilevered element which is cantilevered from the slide, and a first shaft supported by the cantilevered element and connected to the support;
a first motor connected to the first shaft and supported by the cantilevered element;
wherein the rotation mechanism comprises a second shaft and a second motor;
wherein the second shaft is rotatable independently of the first shaft.

US Pat. No. 10,477,873

DEVICE AND METHOD FOR REMOVAL OF PINBONES FROM A FISH FILLET

1. An apparatus, designed and configured for the removal of pin bones from a fish fillet that has been completely separated from the skeleton, comprising a tool having a clamping mechanism for clamping and releasing individual pin bones, a drive for the rotary driving of at least parts of the clamping mechanism and means for transmitting the rotational movement from the drive to the clamping mechanism, characterised in that the clamping mechanism comprises a base body that can be driven such that it rotates about a rotational axis, with which at least two clamping jaws are associated, which clamping jaws define a resulting central axis M and are for clamping and releasing the pin bones, wherein the clamping jaws are designed and configured such that they can move towards and away from one another, and the drive is designed and configured for exerting an oscillating rotational movement of the base body about the rotational axis and thereby of the clamping jaws about the central axis M.

US Pat. No. 10,477,867

OVEN APPLIANCE WITH AIR CURTAIN

Haier US Appliance Soluti...

1. An oven appliance defining a vertical direction, a lateral direction, and a transverse direction, the vertical, lateral, and transverse directions being mutually perpendicular, the oven appliance comprising:a housing defining a cooking chamber, the cooking chamber extending between a top portion and a bottom portion along the vertical direction, the housing also defining an opening for accessing the cooking chamber of the housing, the cooking chamber extending from the opening to a wall along the transverse direction;
an upper heating element array positioned within the housing at the top portion of the cooking chamber;
a baking stone positioned within the housing at the bottom portion of the cooking chamber;
a lower heating element array positioned within the housing below the baking stone adjacent the bottom portion of the cooking chamber;
a duct at least partially defined by the wall and extending between an inlet defined in the wall below the baking stone and an outlet defined in the wall above the upper heating element array;
a hollow casing mounted to the housing at the opening of the housing, the hollow casing defining a lower portion and an upper portion spaced apart from the lower portion along the vertical direction, the hollow casing comprising an ambient air intake in the lower portion proximate to and contiguous with interior room ambient atmosphere about the housing, a smoke inlet proximate to and contiguous with the cooking chamber, a venting exit in the upper portion proximate to and contiguous with the interior room ambient atmosphere about the housing, and an air curtain outlet proximate to the opening of the housing, wherein the oven appliance defines a first air flow path from the lower portion of the hollow casing to the upper portion of the hollow casing via the duct and a second air flow path from the lower portion of the hollow casing to the upper portion of the hollow casing via a side portion of the hollow casing; and
an air handler located within the hollow casing and operable to cause gases to flow into the ambient air intake and the smoke inlet, such that the gases from each of the ambient air intake and the smoke inlet intermix within the hollow casing and the mixed gases flow to the venting exit and to the air curtain outlet;
wherein the opening of the housing defines a width along the lateral direction, the air curtain outlet also defining a width along the lateral direction, the width of the air curtain outlet being substantially equal to the width of the opening.

US Pat. No. 10,477,857

TRACKING SYSTEM AND METHOD

Infestation Tracking Syst...

1. An infestation tracking system comprising:a data receiver arranged to: i) receive work data detailing an infestation at a location, from a data provider logged in to the infestation tracking system, and ii) receive (a) property data related to properties of interest from users who have subscribed to an alert system, the property data of each property of interest indicative of an address or location of the property, and (b) contact information for a user associated with the property;
a module arranged to upon receiving the work data: i) update an existing record in a database according to the received work data upon determining the record corresponds to the location based on a geographical matching process by including the received work data and automatically appending data provider data of the data provider based on a logged-in account, ii) create a new record in the database according to the received work data upon determining that no record corresponding to the location exists based on a geographical matching process by including the received work data and automatically appending data provider data of the data provider based on the logged-in account, and iii) responsive to receipt of the work data, determine whether any properties of interest are in a risk area corresponding to the updated record or the new record, based on a geographical matching process; and
a data transmitter arranged to, upon the module determining that one or more properties are in a risk area, transmit a notification based on the updated record or the new record to each respective user using the contact information for the user associated with the property, the notification including an indication of the data provider.

US Pat. No. 10,477,854

MOUSETRAP WITH ALARMING AND REMINDING FUNCTIONS

1. A mousetrap with alarming and reminding functions, comprising a mousetrap shell, wherein a mouse cavity is formed inside the mousetrap shell; a mousetrap inlet communicated with the mouse cavity is formed in the mousetrap shell; a mouse clip and a vibration induction alarm are disposed inside the mousetrap shell; the vibration induction alarm comprises: an alarm shell, and a circuit board, a power supply device, a buzzer to give an alarm and a vibration sensor to detect vibration strength of the mousetrap which are respectively installed inside the alarm shell; the vibration sensor and the buzzer are respectively connected to the circuit board; a voltage comparison module and an alarm signal control module are disposed on the circuit board; the alarm signal control module is electrically connected with the power supply device, the voltage comparison module and the buzzer respectively; and the voltage comparison module is electrically connected with the vibration sensor and the power supply device respectively; the mousetrap shell comprises a bottom shell and a flipping cover, shaft body installing holes are respectively formed in two side surfaces of a front end of the flipping cover; shaft bodies on both sides of the alarm shell are inserted into the shaft body installing holes of the flipping cover so that the flipping cover and the bottom shell realize rotatable connection; and the flipping cover can flip up and down relative to the bottom shell, so as to open or close the mousetrap shell.

US Pat. No. 10,477,853

HEATING CHAMBER SYSTEM AND METHOD FOR INSECT EXTERMINATION

ZAPPBUG, INC., Seattle, ...

1. A heating chamber system comprising:an enclosed heating chamber;
a bottom portion defining a lower portion of the enclosed heating chamber and includes a floor skirt and a floor;
a top portion defining an upper portion of the enclosed heating chamber and including a plurality of sidewalls and a roof;
a collapsible architecture configured to support the top portion; and
a heating system comprising:
a heater configured to generate and expel heated air, the heater including a set of electrically isolated heating elements;
a control system operably coupled to the heater and configured to control the generation of the heated air by the heater, the control system including:
a touch-screen interface; and
more than two electrically isolated power cord assemblies configured to simultaneously provide power of a same voltage to a respective electrically isolated heating element of the set of electrically isolated heating elements, the power of the same voltage originating from separate outlet receptacles associated with one or more circuits having the same voltage that the power cord assemblies are respectively plugged into simultaneously, each power cord assembly of the power cord assemblies having a cord and a plug;
wherein the control system is operably connected to a remote user device via a wireless network such that the control system can send data regarding a state of the heating chamber to the user device and such that the user device can send control instructions to the control system such that the control system controls the state of the heating chamber based on the control instructions received from the user device;
wherein the control system is configured to generate a treatment cycle based on the instructions received from the remote user device and the touch-screen interface, where the treatment cycle includes:
a first portion that substantially utilizes a maximum power available from the one or more power circuits that the heating chamber system draws the power from, the first portion having a duration of about 3 hours; and
a second portion after the first portion having a lower power-consumption mode that utilizes 80% or less of the maximum power available from the one or more power circuits;
wherein the control system is further configured to generate the treatment cycle based at least in part on a received first indication of whether the power cord assemblies are coupled with two or three separate electrical power circuits of the one or more power circuits, the first indication receivable via at least one of the user device and the touch screen interface;
wherein the control system is further configured to generate the treatment cycle based at least in part on a received second indication of an amperage of the two or three separate electrical power circuits of the one or more power circuits, the second indication receivable via at least one of the user device and the touch-screen interface.

US Pat. No. 10,477,852

METHOD FOR THE PREPARATION AND IMPROVEMENT OF HORSESHOES

Travel and Trade BVBA, S...

6. A method of upgrading a horseshoe having a support surface to be attached directly to a hoof of an ungulate and an exposed ground-facing surface to be contacting a ground surface when attached to the hoof, the method comprising the steps of:adding a first groove on the support surface and a second groove opposite the first groove on the ground-facing surface on a bridge of the horseshoe, the horseshoe not originally having the first groove on the support surface or the second groove on the ground-facing surface, the first groove extending across the bridge from an inner circumference to an outer circumference of the horseshoe and the second groove extending across the bridge, the horseshoe being composed of a metal;
responsive to the adding the first and second grooves, fitting the horseshoe as a single, unitary piece to the hoof;
responsive to the fitting, deepening the first groove in the support surface while the horseshoe is unattached to the hoof, by partially cutting or sawing the horseshoe starting at or along the first groove across a width of the bridge without cutting completely through the bridge such that the horseshoe remains a single, unitary piece;
responsive to the deepening, nailing the support surface to the hoof such that a sole of the hoof remains uncovered by the attached horseshoe after the attaching; and
responsive to the nailing, sawing or cutting the horseshoe starting at or along the second groove and then completely through the deepened first groove while the horseshoe remains nailed to the hoof and the sole remains uncovered by the attached horseshoe to divide the single, unitary piece into two separate parts, thereby permitting lateral and medial movement of the hoof along the ground surface.

US Pat. No. 10,477,848

SPOOL BRAKE DEVICE

SHIMANO INC., Sakai, Osa...

16. A dual bearing reel comprising:a reel body;
a spool coupled to the reel body;
a handle coupled to the reel body; and
a spool brake device comprising:
a brake unit configured to electrically brake a spool of the spool brake device;
a detector configured to detect increase and decrease of the rotational speed of the spool; and
a controller configured to control a braking force of the brake unit,
wherein the braking force is controlled by the controller based on a detected increase or decrease of the rotational speed of the spool such that when the rotational speed of the spool is detected to be increasing, the controller sets the braking force according to a regular braking mode, and when the rotational speed of the spool is detected to stop increasing, the controller sets the braking force according to a first braking mode, wherein the braking force of the first braking mode is less than the braking force of the regular braking mode.

US Pat. No. 10,477,846

SPOOL FOR FISHING REEL

Shimano Inc., Osaka (JP)...

1. A spool for a fishing reel attached to a reel body of the fishing reel, which is capable of casting a fishing line forward, and moving back and forth along a spool axis together with a rotation of a handle that is attached to the reel body, comprising:a spool body having a bobbin trunk around which the fishing line is capable of being wound, an annular flange extending from a front end portion of the bobbin trunk in a radially outward direction that intersects the spool axis, and a tubular connecting portion extending forward from the annular flange;
a spool ring surrounding an outer peripheral edge of the flange from the radially outward direction, and attached to the flange so as to be separable from a front direction;
a fixing ring attached to the spool body via the tubular connecting portion so as to be separable from the front direction and configured to fix the spool ring against the flange from the front direction; and
a first regulating part configured to regulate relative movement of the fixing ring with respect to the spool body detachably attached to the tubular connecting portion by being inserted into the tubular connecting portion in a direction transverse to the spool axis.

US Pat. No. 10,477,841

METHOD AND DEVICE SUITABLE FOR INCUBATING AVIAN EGGS

1. A method for incubating avian eggs, comprising:a. introducing avian eggs into an incubation chamber having an oxygen-containing atmosphere;
b. subsequent to ‘a’, incubating said eggs in said incubation chamber for a period of time that is not less than 25% of the natural incubation period of said eggs;
c. during said period of time of the incubating, changing an orientation of said eggs at a frequency of not less than once every two days; and
d. during said period of time of said incubating, varying a temperature of said atmosphere in said incubation chamber at a frequency of not less than five times a day, the varying comprising:
increasing the temperature of the atmosphere from a first temperature to a second temperature, the difference between the first temperature and the second temperature being not less than 1.0° C.; and subsequently
reducing the temperature from the second temperature to a third temperature, the difference between the second temperature and the third temperature being not less than 1.0° C.wherein the rate of said increasing the temperature of the atmosphere is not greater than 0.9° C./5 minutes;wherein said reducing of said second temperature to said third temperature commences after a period of at least one minute subsequent to attaining said second temperature; andthe rate of said reducing the temperature of the atmosphere is not greater than 0.9° C./5 minutes.

US Pat. No. 10,477,839

DOG LEASH ASSEMBLY

1. A dog leash assembly being configured to be worn around a waist thereby facilitating hands-free restraint of a dog, said assembly comprising:a belt being configured to be worn around a waist, said belt having a first end and a second end, said belt having a cut to define a first portion of said belt and a second portion of said belt, each of said first portion and said second portion having a terminal end;
a first fastener being coupled to said first end of said belt; and
a second fastener being coupled to said second end of said belt, said first fastener being complementary with respect to said second fastener wherein each of said first fastener and said second fastener is configured to retain said belt around the waist;
a decal being coupled to said second fastener, said decal being comprised of a reflective material wherein said decal is configured to reflect light thereby enhancing visibility of said second fastener in a darkened environment;
a pouch being removably coupled to said belt wherein said pouch is configured to be positioned on the waist; and
a leash unit being removably coupled to said belt, said leash unit being configured to be coupled to a dog thereby facilitating hands-free restraint of the dog.

US Pat. No. 10,477,835

FEEDING APPARATUS FOR ANIMALS

Crystal Spring Colony Far...

1. An apparatus for feeding animals comprising:a feed dispensing system;
a plurality of feed dispensing containers at each of which at least one animal can take feed material;
each of said plurality of feed dispensing containers comprising: a respective upstanding feed supply duct portion connected to the feed dispensing system so as to receive feed therefrom;
the respective feed supply duct portion being configured so that feed therein from the feed dispensing system falls by gravity to the respective feed dispensing container;
a rotary drive member mounted at the duct portion and including a plurality of paddle blades of a paddle wheel mounted for rotation about an axis of the wheel such that falling feed in the duct acts to drive the paddle blades to rotate the wheel about the axis;
a dispensing container containing a particulate additive material mounted on one side of the duct portion;
a feed wheel at the dispensing container driven by the paddle wheel which meters particulate additive material from the dispensing container to an outlet thereof which is arranged to discharge into the feed duct portion to mix with the feed therein.

US Pat. No. 10,477,834

GRAZING SYSTEM AND METHOD

Pasturebird, Inc., Murri...

1. A grazing system comprising:a poultry enclosure for containing poultry that extends generally across a side of a field, the field comprising a grazing field for one or both of poultry and livestock, the poultry enclosure comprising:
two side walls including a first side walls and a second side wall extending generally across the side of the field,
a third wall coupled to the first side wall and the second side wall that connects the two side walls, and
a fourth wall coupled to the first side wall and the second side wall, opposite the third wall, that connects the two side walls to form the poultry enclosure, wherein the poultry enclosure moves one or both of linearly and laterally over the field;
a motor; and
one or more processors configured by machine readable instructions to actuate the motor causing the poultry enclosure to move at least partially over the field, wherein actuation of the motor is programmatic such that movement of the poultry enclosure over the field is initiated via the machine readable instructions.

US Pat. No. 10,477,826

MILKING BOX WITH ROBOTIC ATTACHER

Technologies Holdings Cor...

1. A method, comprising:positioning a robotic attacher under a dairy livestock located in a milking stall, wherein the robotic attacher extends along a longitudinal axis and comprises a nozzle;
rotating the robotic attacher about the longitudinal axis such that the nozzle moves to a position generally on the top of the robotic attacher;
performing a spraying operation using the nozzle; and
retracting the robotic attacher from under the dairy livestock.

US Pat. No. 10,477,784

IRRIGATION SYSTEM

6. A method for irrigating cropland comprising:providing a water delivery pipe assembly comprising a plurality of delivery pipes and a plurality of drive motors;
configuring the water delivery pipe assembly to maintain a longitudinal alignment of the delivery pipes with respect to each other for at least one of: center pivot irrigator travel and linear-move irrigator travel; and
configuring the water delivery pipe assembly wherein the plurality of drive motors comprises a plurality of sets of two of the drive motors and during the maintaining of the longitudinal alignment of the delivery pipes with respect to each other, for each set of two motors, when one motor in the set of two motors is in operation or is operational the other drive motor in the set of two motors is not in operation or is not operational; and
wherein the water delivery pipe assembly is defined by a first end and a distal second end and the plurality of drive motors are distributed along the water delivery pipe assembly between the first and second ends thereof and the method further comprises locating a first drive motor proximate to the first end and locating a second motor proximate to the second end as one of the plurality of sets of two drive motors.

US Pat. No. 10,477,780

MULTIPLE CELL TRAY WITH MEDIA PLUGS

HGCI, Inc., Las Vegas, N...

1. A multiple cell horticulture propagation tray arranged in rows of star-shaped cells forming a substantially rectangular shaped tray having the cells formed therein, combined with inserted cylindrically shaped growing media plugs comprising peat moss with an amount of biochar, and enveloped to retain moisture within the growing media plugs, wherein each of the cells comprise a cup having a top rim and a bottom perimeter and flutes running from the top rim to the bottom perimeter comprising inwardly radiused indentations that reduce an amount of interior space within the cell.

US Pat. No. 10,477,779

BOTANICAL AIR FILTRATION SYSTEM AND METHOD

Purdue Research Foundatio...

1. A botanical air filtration system comprising:an enclosure;
a wall within the enclosure;
two or more horizontal plant beds on which living plants are supported and grow within the enclosure, the plant beds being arranged in vertical tiers along the wall, each of the plant beds comprising a growth media and a tray that contains the growth media, each of the trays having a bottom surface that supports the growth media and holes in the bottom surface through which air moving through the plant bed is able to flow downwardly through the growth media and then exit the plant bed through the bottom surface of the tray;
an airflow pattern within the enclosure wherein air moving through the enclosure flows horizontally across each of the plant beds from a front of the tray thereof to a back of the tray thereof, over and through leaves of the plants of the plant beds, then downwardly through the growth media, then downwardly through the holes in the bottom surface of the tray, and then out of the enclosure, the holes in the bottom surface of each of the trays defining a hole pattern that promotes a uniform air flow across the tray;
an irrigation system for watering the plants; and
a lighting system for simulating sunlight.

US Pat. No. 10,477,778

PLANT INFILTRATION TRAY

MEDICAGO INC., Quebec, Q...

1. A plant tray assembly for holding at least one plant pot containing at least one plant and associated media, the plant tray assembly comprising:a base retaining tray having an upper surface defining a plurality of cavities for receiving the at least one plant pot therein; and
a top plate mounted on said base retaining tray such that an inwardly-facing surface of the top plate faces the upper surface of the base retaining tray, the top plate being displaceable relative to the base retaining tray in a plane substantially parallel to said upper surface, the top plate having a plurality of apertures defined therein and which extend transversely therethrough;
the top plate and the base retaining tray being relatively displaceable between a loading and unloading position and a locked operative position of the plant tray assembly, the apertures of the top plate and the cavities of the base retaining tray being substantially aligned in said loading and unloading position such as to define open plant pot receiving channels, the apertures of the top plate and the cavities of the base retaining tray being at least partially misaligned in said locked operative position such that a retaining portion of the inwardly-facing surface of the top plate obstructs part of the corresponding cavity in the base retaining tray, the at least one plant pot being retained within the base retaining tray and a part of the at least one plant protruding through the apertures of the top plate in said locked operative position; and
the plant tray assembly being invertible to invert the at least one plant pot, the inverted at least one plant pot abutting the retaining portion of the inwardly-facing surface of the top plate and being retained within the plant pot receiving channels when the top plate and the base retaining tray are in the locked operative position.

US Pat. No. 10,477,770

DRAPER PLATFORM WITH RECONFIGURABLE CENTRAL ROLLER BAFFLE

1. A draper platform for mounting on a feeder house of an agricultural combine, the draper platform comprising:a frame;
a center belt conveyor to carry cut crop material rearwardly towards a center opening in the frame through which crop may be fed into a feeder house;
a left side belt conveyor to carry cut crop material to the center belt conveyor;
a right side belt conveyor to carry cut crop material to the center belt conveyor;
at least one elongate reciprocating knife assembly extending along a front edge of each of the center belt conveyor, the left side belt conveyor and the right side belt conveyor;
a conveyor drum above the center belt conveyor; and
a reconfigurable central roller baffle comprising:
a rotatable support rotatably supported above the conveyor drum; and
a crop driver removably mounted to the rotatable support.

US Pat. No. 10,477,768

EXTENDABLE DRAPER BELT

CNH Industrial America LL...

1. An agricultural vehicle, comprising:a chassis;
a feeder housing carried by the chassis;
a header coupled to the feeder housing, said header including:
a flexible cutter bar; and
at least one endless belt positioned rearwardly of the flexible cutter bar and configured to travel in a direction of travel for transporting a crop material to the feeder housing, said at least one endless belt including:
a first belt having a first width transverse to said direction of travel; and
a second belt moveably attached to the first belt and having a second width transverse to said direction of travel and a front edge, said second belt including:
a plurality of elongated protrusions transverse to said direction of travel and configured for contacting the crop material; and
an engaging feature adjacent to the front edge and configured for moving the second belt in accordance with said flexible cutter bar,
wherein said second belt is slideable in a transverse direction to said direction of travel such that said second belt slides forwardly or rearwardly relative to said first belt and in accordance with a movement of said flexible cutter bar.

US Pat. No. 10,477,756

CORRECTING AGRONOMIC DATA FROM MULTIPLE PASSES THROUGH A FARMABLE REGION

10. A computer-implemented method for correcting agronomic data associated with a farmable region, the method comprising:for each sub-region in a plurality of sub-regions of the farmable region, obtaining respective agronomic data indicating an area of the sub-region and a value for the sub-region, wherein the value for the sub-region comprises (1) an aggregate value of an agronomic parameter for the sub-region derived from data collected by one or more sensors during a pass through the sub-region and/or (2) a ratio of the aggregate value to the area of the sub-region;
identifying a part of a first sub-region that overlaps with a part of a second sub-region, wherein the first and second sub-regions are included in the plurality of sub-regions;
determining whether the second sub-region is associated with a first-in-time pass by the one or more sensors through the overlapping parts of the first and second sub-regions or a second-in-time pass by the sensors through the overlapping parts; and
in a case in which the second sub-region is associated with the second-in-time pass, determining a corrected value for the second sub-region based, at least in part, on the value for the first sub-region, the value for the second sub-region, the area of the first sub-region, the area of the second sub-region, and/or an area of the overlapping parts of the first and second sub-regions.

US Pat. No. 10,477,754

IMPROVEMENTS FOR FOLDING AN AGRICULTURAL MACHINE

ROTACON ENGINEERING LIMIT...

1. An agricultural machine configured to be drawn over a soil surface in a field or from place to place by a prime mover, the machine comprising:a frame or chassis carrying machinery support frames that are used to support selected agricultural equipment; and
a raised primary beam extending from a hitching point to which the prime mover is reversibly connected by a pivoted connection, to a rear trailer, the primary beam defining a median line of symmetry for the frame or chassis,
wherein the frame or chassis includes four beams connect together by four joints, each of the joints being pivotable about a separate vertical axis of rotation,
wherein the beams of the frame or chassis include a first secondary beam and a second secondary beam pivotally connected to each other and to the primary beam at a first one of the joints at a first end of each of the first secondary beam and second secondary beam,
the first secondary beam is pivotally connected at a second end by a second one of the joints along a first tertiary beam,
the second secondary beam is pivotally connected at a second end by the third one of the joints along a second tertiary beam,
a first end of the first tertiary beam is connected at a fourth one of the joints to a first end of the second tertiary beam,
the first tertiary beam is extended beyond the second joint along the entire length of a first machinery support frame and the second tertiary beam being extended beyond the third joint along the entire length of a second machinery support frame, and
the agricultural equipment is pivotally connected to the first machinery support frame and to the second machinery support frame.

US Pat. No. 10,477,752

ROW UNIT FOR AGRICULTURAL IMPLEMENT

Dawn Equipment Company, ...

1. A downforce control system for a planter row unit, comprising:a downforce actuator associated with the planter row unit to urge the row unit downwardly with a controllable force that can be adjusted,
said planter row unit producing a gauge wheel downforce during planting operations,
said downforce actuator disposed to change said gauge wheel downforce when actuated;
a control module for defining a desired gauge wheel downforce;
a valve in fluid communication with said downforce actuator for adjusting the fluid pressure supplied to said actuator, said valve associated with the planter row unit; and
a controller for adjusting the gauge wheel downforce produced by said downforce actuator.
US Pat. No. 10,477,806

INBRED CORN LINE 2EEXI2053

Agrigenetics, Inc., Indi...

1. Seed of corn inbred line designated 2EEXI2053, or a part thereof, representative seed of the line having been deposited under ATCC Accession No. PTA-124402.
US Pat. No. 10,477,807

PLANTS AND SEEDS OF HYBRID CORN VARIETY CH814115

Monsanto Technology LLC, ...

1. A seed of hybrid corn variety CH814115, produced by crossing a first plant of variety CV690087 with a second plant of variety CV644326, wherein representative seeds of said varieties CV690087 and CV644326 are deposited under ATCC Accession Nos. PTA-125238 and PTA-125218, respectively.
US Pat. No. 10,480,122

CARPET COATING COMPOSITIONS

Wacker Chemie AG, Munich...

1. A method of coating a carpet, comprising coating the carpet with a mixture comprising an aqueous dispersion of a vinyl acetate polymer and an aqueous dispersion of a vinyl acetate-ethylene copolymer.
US Pat. No. 10,477,813

PLANTS AND SEEDS OF HYBRID CORN VARIETY CH401605

Monsanto Technology LLC, ...

1. A seed of hybrid corn variety CH401605, produced by crossing a first plant of variety CV079395 with a second plant of variety CV056579, wherein representative seeds of said varieties CV079395 and CV056579 are deposited under ATCC Accession Nos. PTA-123515 and PTA-123062, respectively.
US Pat. No. 10,481,153

INTEGRATED COMPOUND DISCOVERY SYSTEMS AND METHODS

Wake Forest University, ...

1. A sequencing device comprising:(a) a spatially addressable sequencing array, said array comprising a plurality of separate and discrete sequencing locations thereon, said separate and discrete sequencing locations contacted with at least one sequencing reagent;
(b) a plurality of different oligomers operably connected to said spatially addressable sequencing array at different ones of said separate and discrete sequencing locations;
(c) a tag sequence which is complementary to, and is hybridized to, each of said oligomers; and
(d) a candidate chemical operably connected to each of said tag sequences,
wherein each of said separate and discrete sequencing locations is a unique identifier for its corresponding oligomer
and wherein said tag sequence is a unique identifier for its connected candidate chemical.
US Pat. No. 10,477,817

SOYBEAN VARIETY 5PBZT32

PIONEER HI-BRED INTERNATI...

1. A plant or a seed of soybean variety 5PBZT32, representative seed of the variety having been deposited under ATCC Accession Number PTA-126071.
US Pat. No. 10,477,819

SOYBEAN CULTIVAR 75162339

M.S. Technologies, L.L.C....

1. A plant of soybean cultivar 75162339, representative seed of said soybean cultivar having been deposited under ATCC Accession No. PTA-125364.
US Pat. No. 10,480,130

VOID REDUCING ASPHALT MEMBRANE COMPOSITION, METHOD AND APPARATUS FOR ASPHALT PAVING APPLICATIONS

Heritage Research Group, ...

1. An asphalt composition comprising:an asphalt binder;
an elastomeric polymer;
a wax modifier; and
a filler selected from fumed silica and fumed alumina,
wherein the composition is formulated to include 85 to 97 wt. % of the asphalt binder,
1 to 6 wt. % of the elastomeric polymer,
1 to 5 wt. % of the wax modifier, and
1 to 10 total wt. % of the filler selected from fumed silica and fumed alumina.
US Pat. No. 10,481,159

IL-6 SIGNALING AND BREAST CANCER

CITY OF HOPE, Duarte, CA...

1. A method of detecting IL-6 activity in a breast cancer patient in remission, the method comprising the steps of:(i) obtaining a biological sample comprising CD4+ T cells from the breast cancer patient in remission;
(ii) contacting the biological sample with either: (a) an IL-6 pathway detection agent capable of binding an IL-6 pathway protein, wherein the IL-6 pathway protein is phosphorylated STAT1, phosphorylated STAT3, IL-6R?, or ADAM17, thereby forming a detectable complex; or (b) an IL-6 pathway probe capable of hybridizing an IL-6 pathway mRNA expression sequence, wherein the IL-6 pathway mRNA expression sequence is gp130; thereby forming a hybridization complex; and
(iii) detecting and/or quantifying either: (a) the detectable complex; or (b) the hybridization complex, respectively;thereby detecting IL-6 activity in the breast cancer patient in remission.
US Pat. No. 10,477,824

COTTON VARIETY PX339042W3FE

Phytogen Seed Company, LL...

1. A seed of cotton variety designated PX339042W3FE, or a regenerable part thereof, representative seed of the variety having been deposited under ATCC Accession No. PTA-123651 on Nov. 15, 2016.
US Pat. No. 10,477,825

COTTON VARIETY PX339054W3FE

Phytogen Seed Company, LL...

1. A seed of cotton variety designated PX339054W3FE, or a regenerable part thereof, representative seed of the variety having been deposited under ATCC Accession No. PTA-123652 on Nov. 15, 2016.
US Pat. No. 10,479,882

ROTATIONAL MOLDABLE COMPOSITION COMPRISING POLYETHYLENE, AND A BLEND OF A PIGMENT AND A POLYETHYLENE COPOLYMER

TEKNOR APEX COMPANY, Paw...

1. A physical, dry color composition, comprising:a mixture of a preblend of a pigment-polyethylene copolymer, and polyethylene;
said pigment-copolymer preblend derived from about 0.06 to about 0.90 parts by weight of one or more pigments and about 1 part by weight of one or more polyethylene-?-olefin copolymers, said amounts based upon about 100 parts by weight of said polyethylene.
US Pat. No. 10,477,833

LOW DENSITY PET LITTERS AND METHODS OF MAKING SUCH PET LITTERS

1. A method of making a pet litter comprising:compacting a material comprising clay and expanded perlite fines to form a compacted material comprising expanded perlite fines, wherein the compacting is performed at a pressure from about 500 to about 1,300 psi;
breaking the compacted material comprising expanded perlite fines to form particles of the compacted material comprising expanded perlite fines;
separating the particles which have a size within a predetermined size range from a remainder of the particles;
drying the particles which have the size within the predetermined size range; and
using the dried particles as at least a portion of the pet litter, wherein the method does not contain activated carbon.
US Pat. No. 10,479,123

SECURITY FEATURE AND DOCUMENT OF VALUE

1. A security feature for securing value documents, comprising a chemically unstable inorganic feature substance and a stabilizing component comprising a substance that stabilizes the feature substance, said substance having at least the same solubility in water as the feature substance to be protected and releasing ions when said substance is decomposed, which ions conform to the ions of the feature substance at least in part.
US Pat. No. 10,479,902

DURABLE AND FLEXIBLE INK COMPOSITION FOR HIGH-QUALITY/HIGH-DEFINITION SCREEN PRINTING, PRINTED PRODUCT OBTAINED BY SCREEN PRINTING SAID INK COMPOSITION, AND MANUFACTURING METHOD FOR SAID PRINTED PRODUCT

TEIKOKU PRINTING INKS MFG...

1. An ink composition for screen printing to be used on a thermoplastic resin substrate, the ink composition comprising:at least one solvent having a boiling point of not less than 170° C. and that is selected from the group consisting of butylcellosolve acetate, dialkyl adipate ester, isophorone, 3-methoxy-3-methylbutanol, 3-methoxy-3-methylbutyl acetate, coal tar naphtha, diethyleneglycol monoethyl ether, diethyleneglycol monoethyl ether acetate, diethyleneglycol monobutyl ether, triethyleneglycol monobutyl ether, triethyleneglycol monobutyl ether acetate, (meth)acrylate monomer, a vinyl ether monomer, and an amide monomer, wherein the amount of the at least one solvent having a boiling point of not less than 170° C. is not less than 70 mass % of a total weight of all solvent in the ink composition; and
at least one thermoplastic polymer that can produce printed matter and has a weight-average molecular weight in the range of 4000 to 100,000, and a Tg (softening point) of 20 to 95° C., wherein the amount of the at least one thermoplastic polymer in the ink composition is in the range of 10 mass % to 70 mass % with respect to a total weight of the ink composition, and wherein the at least one thermoplastic polymer is selected from the group consisting of polyester resins, vinyl chloride-vinyl acetate copolymer resins, butyral resins, polyether-urethane resins, polyester-urethane resins, polycarbonate-urethane resins, epoxy resins, phenol resins, acrylic resins, polyamide resins, polyamideimide resins, polyolefin resins, chlorinated polyolefin resins, chlorinated rubber, melamine resins, urea resins, modified cellulose resins, rosin resins, maleic acid resins, natural resins, alkyd resins, and combinations thereof,
wherein:
the ink composition has:
a viscosity of 5 to 180 Pas as measured with a BH-type rotating viscosimeter at 25° C.,
a thixotropic index (TI value) of 2.0 to 8.0, and
a measured flow radius value between 13.0 to 24.0 mm after 1 minute from a start of measurement by a flow property measuring method using a spread meter at 25° C. according to JIS K5701-1:2000,
the ink composition satisfies an inequality “F60”?“F45”?1.0 mm, wherein “F60” is defined as the measured flow radius value after 1 minute and “F45” is defined as the measured flow radius value after 45 seconds from the start of measurement by a flow property measuring method using a spread meter,
the ink composition is adapted to produce printed matter in a single step comprising both a solid image pattern and a fine image pattern with the spreading width of no more than 10 ?m from image design dimensions of a printing plate at one of edges and outlines of any section in a printed image, for avoiding a visible state of enlarged sections of the printed image and a halated printed image, when producing printed matter by screen printing onto a thermoplastic resin substrate using a 360-mesh screen printing plate formed by a high-strength, non-deforming stainless steel mesh with a filament diameter of 25 ?m, the thermoplastic resin substrate being a flat base material selected from the group consisting of polycarbonate resin, treated or untreated polyester resin, acrylic resin, vinyl chloride resin, polypropylene resin, polyethylene resin, and combinations thereof, and
the ink composition, when applied, produces a printed image coating film having an elongation percentage according to comparison between a length before shaping and a length after shaping by heating in a range between about 150° C. to 190° C. of the printed image, of not less than 250% under vacuum forming or pressure forming.
US Pat. No. 10,479,906

USE OF FUNGAL PIGMENTS FROM WOOD-STAINING FUNGI AS COLORANTS IN WOOD FINISHES AND PAINTS

Oregon State University, ...

1. A composition comprising a fungal pigment suspended or solvated in an oil carrier, wherein the fungal pigment is an extracellular pigment from a fungi selected from the Chlorociboria genus, the Scytalidium genus, or any mixture thereof, and wherein the composition does not include an organic solvent.
US Pat. No. 10,482,991

SYSTEMS AND METHODS FOR SAMPLING AND ANALYSIS OF POLYMER CONFORMATIONAL DYNAMICS

ZYMEWORKS INC., Vancouve...

1. A method of sampling and analysis of protein conformational dynamics by searching the conformation space of a protein to determine whether a three-dimensional conformation of the protein can co-engage each antigen in a plurality of target antigens, the protein comprising a first plurality of residues, the method comprising:at a computer system having one or more processors and memory storing one or more programs to be executed by the one or more processors:
(A) obtaining from the memory an initial set of three-dimensional coordinates {x1A_init, . . . , xNA_init, x1B_init, . . . , xMB_init, x1C_init, . . . , xPC_init, . . . } for the protein, wherein
the polymer comprises a plurality of domains,
each respective xiA in {x1A_init, . . . , xNA_init, x1B_init, . . . , xMB_init, x1C_init, . . . , xPC_init, . . . } is a three dimensional coordinate for an atom in a first domain in the plurality of domains,
each respective xiB in {x1A_init, . . . , xNA_init, x1B_init, . . . , xMB_init, x1C_init, . . . , xPC_init, . . . } is a three dimensional coordinate for an atom in a second domain in the plurality of domains, and
each respective xiC in {x1A_init, . . . , xNA_init, x1B_init, . . . , xMB_init, x1C_init, . . . , xPC_init, . . . } is a three dimensional coordinate for an atom in a first hinge of the protein, wherein the first hinge comprises a second plurality of residues that is a subset of the first plurality of residues, wherein the protein is characterized by an ability for the first and second domain to pivot with respect to each other about the first hinge;
(B) altering the initial set of three-dimensional coordinates of the protein by pivoting the first domain with respect to the second domain about the first hinge thereby obtaining an altered set of three-dimensional coordinates {x1A_alt, . . . , xNA_alt, x1B_alt, . . . , xMB_alt, x1C_alt, . . . , xPC_alt, . . . } for the protein, wherein
all atoms within the first domain are held fixed with respect to each other during the altering, and
all atoms within the second domain are held fixed with respect to each other during the altering;
(C) scoring, using a scoring module, a calculated potential energy of the altered set of coordinates versus a calculated potential energy of the initial three-dimensional coordinates for the protein with a Metropolis criterion, wherein, when the Metropolis criterion is satisfied, the altered set of three-dimensional coordinates is accepted as the initial set of three-dimensional coordinates;
(D) performing additional instances of the altering (B) and the scoring (C) until an energy of the altered set of three-dimensional coordinates {x1A_alt, . . . , xNA_alt, x1B_alt, . . . , xMB_alt,, x1C_alt, . . . xPC_alt, . . . } satisfy the Metropolis criterion; and
(E) evaluating whether the altered set of three-dimensional coordinates {x1A_alt, . . . , xNA_alt , x1B_alt, . . . , xMB_alt, x1C_alt, . . . , xPC_alt, . . . } can co-engage each antigen in the plurality of target antigens by docking the altered set three-dimensional coordinates to a model of the plurality of antigens.
US Pat. No. 10,484,535

METHOD AND SYSTEM FOR TEXT ENABLEMENT OF LANDLINE TELEPHONE NUMBER WITH THREAD AND GROUP CHAT ENABLEMENT

1. A system for converting a telephone number not provisioned for receipt and output of Short Messaging Service (SMS) text messages into an SMS-to-electronic mail conversion enabled telephone number, wherein the system is configured to:assign a carrier's Service Profile IDentifier (SPID) to the telephone number not provisioned for receipt and output of SMS text messages;
receive an SMS text message from an SMS text message sender, wherein the SMS text message is addressed to be received at the telephone number not provisioned for receipt and output of SMS text messages and the SMS text message is routed to the carrier's SMS gateway based on the carrier's assigned SPID;
include content of the SMS text message in an electronic mail message to a user associated with that telephone number not provisioned for receipt and output of SMS text messages, and sending the electronic mail message to the user at a computer and/or mobile device associated with the user, wherein the content of the SMS text message is included in the electronic mail message sent to the user automatically in response to receiving the SMS text message addressed to the telephone number not provisioned for receipt and output of SMS text messages;
receive a user's electronic mail message response to the electronic mail message including content of the SMS text message, wherein content of the electronic mail message response is formulated by the user on the computer or the mobile device and sent from the computer or the mobile device; and
include the content of the electronic mail message response in a response SMS text message sent to a telephone number of the SMS text message sender,
wherein the response SMS text message indicates the telephone number not provisioned for receipt and output of SMS text messages as the telephone number sending the response SMS text message, and
wherein the content of the SMS text message, the content of the response SMS text message and any subsequent SMS text messages and response SMS text messages sent between the SMS text message sender and the user are combined in an electronic mail message sent to the user's computer device or mobile phone,
whereby the user is made aware of SMS text messages erroneously sent to their telephone number that is not provisioned for receipt and output of SMS text messages.
US Pat. No. 10,479,916

LATENT TWO-PART POLYURETHANE ADHESIVES CURABLE WITH INFRARED RADIATION

DOW GLOBAL TECHNOLOGIES L...

1. A composition comprising a polyol component and an isocyanate component, wherein:a) the polyol component includes;
i) one or more polyols having a hydroxyl equivalent weight of 400 to 2000 and a nominal hydroxyl functionality of 2 to 4;
ii) one or more aliphatic diol chain extenders; and
iii) one or more latent room temperature organometallic catalysts;
b) the polyisocyanate component includes:iv) one or more polyisocyanate compounds;wherein the polyisocyanate component includes isocyanate groups and the polyol component isocyanate-reactive groups wherein a ratio of a number of the isocyanate groups in the polyisocyanate component to a number of the isocyanate-reactive groups in the polyol component is about 1.0 to about 1.8; and v) one or more carboxylic acid-blocked cyclic amidine compounds and vi) one or more phenol-blocked cyclic amidine compounds are located in the polyol component or the isocyanate component and the composition is useful as a two-component polyurethane adhesive composition.
US Pat. No. 10,481,456

ELECTROCHEMICAL ENERGY STORAGE DEVICES

GENTEX CORPORATION, Zeel...

5. A energy storage device comprising:a first cell comprising an anodic material in an activated state;
a second cell comprising a cathodic material in an activated state;
a porous separator isolating the first cell from the second cell; and
wherein:
the anodic material is a phenazine, a phenothiazine, a triphenodithiazine, a carbazole, a indolocarbazole, a biscarbazole, or a ferrocene;
the cathodic material is a viologen; and
the energy storage device exhibits an open circuit voltage of about 0.2 V to about 1.2 V.
US Pat. No. 10,479,936

PHOSPHOR AND METHOD FOR PRODUCING THE PHOSPHOR

OSRAM OPTO-SEMICONDUCTORS...

1. A phosphor having the general molecular formula (MB)Li3?2x**Al1+2x**O4?4x**N4x**:E, wherein0
US Pat. No. 10,483,531

NEGATIVE ELECTRODE ACTIVE MATERIAL FOR NONAQUEOUS ELECTROLYTE SECONDARY BATTERIES

1. A silicon-containing negative electrode active material for nonaqueous electrolyte secondary batteries, wherein the negative electrode active material particles comprise a surface layer comprising carbon and titanium or aluminum on an entirety or a portion of a surface of a core portion,wherein the core portion comprises: pure silicon; a silicon alloy selected from SiB4 or SiB6, Cu5Si, FeSi2, or Mg2Si; or a silicon compound selected from Si3N4 or SiC in an amount of 90% by mass or more, and
a content of titanium or aluminum in the surface layer is 0.002 to 0.07% by mass of the silicon-containing negative electrode active material particles.
US Pat. No. 10,477,886

FUNCTIONAL NUTRITIONAL BLEND FOR THERMO-METABOLIC PERFORMANCE

SAMI LABS LIMITED, Banga...

1. A composition for inhibiting adipogenesis in mammalian adipocytes consisting essentially of 70-73% w/w Gynostemma pentaphyllum extract, 12-15% w/w Coleus forskohlii extract, 10-12% w/w Zingiber officinale extract and 0.5-1% w/w Piperine.
US Pat. No. 10,479,686

SODIUM THIOSULFATE-CONTAINING PHARMACEUTICAL COMPOSITIONS

Hope Medical Enterprises,...

1. A pharmaceutical composition comprising sodium thiosulfate pentahydrate and one or more pharmaceutically acceptable carriers or excipients, wherein the sodium thiosulfate pentahydrate contains no greater than 8 ppm of non-purgeable organic carbon, contains no greater than 0.05 ppm of mercury, contains no greater than 2 ppm of aluminum, contains no greater than 0.003% by weight of selenium, contains no less than 98% by weight and no greater than about 102% by weight of sodium thiosulfate on an anhydrous basis measured by ion chromatography, has a water content between 32% and 37% by weight, has a heavy metal content of no greater than 10 ppm, contains no greater than 200 ppm of chloride, contains no greater than 0.001% by weight of sulfide, contains no greater than 0.002% by weight of iron, contains no greater than 0.01% by weight of calcium, contains no greater than 0.005% by weight of potassium, contains no greater than 0.1% of sulfite, contains no greater than 0.5% of sulfate, contains no greater than 3 ppm of arsenic, contains no greater than 0.001% by weight of lead, has total aerobic count of microbial load of no greater than 100 CFU/g, has total yeast and mold count of no greater than 20 CFU/g, contains no greater than 0.02 EU/mg of bacterial endotoxins, contains no greater than 0.002% by weight of nitrogen compounds, contains no greater than 0.005% by weight of insoluble matter, contains no greater than 0.01% by weight of residual anti-caking agent, and contains no greater than ICH Q3C (R3) limits of organic volatile impurities, wherein a 10% aqueous solution of the solid sodium thiosulfate pentahydrate at 25° C. is colorless and has a pH between 6.0 and 8.0, and wherein the solid sodium thiosulfate pentahydrate is odorless crystals,wherein the pharmaceutical composition is formulated for parenteral administration; and
wherein the pharmaceutically acceptable carrier or excipient is an aqueous vehicle; a water-miscible vehicle; a non-aqueous vehicle; an antimicrobial agent or preservative against the growth of microorganisms; a stabilizer; a solubility enhancer; an isotonic agent; a buffering agent; an antioxidant; a local anesthetic; a suspending or dispersing agent; a wetting or emulsifying agent; a complexing agent; a sequestering or chelating agent; a cryoprotectant; a lyoprotectant; a thickening agent; a pH adjusting agent; or an inert gas.
US Pat. No. 10,481,486

MASK BLANK, PHASE SHIFT MASK, AND METHOD FOR MANUFACTURING SEMICONDUCTOR DEVICE

HOYA CORPORATION, Tokyo ...

1. A mask blank having a structure in which a phase shift film and a light shielding film are laminated in this order on a transparent substrate,wherein the phase shift film has a function to transmit exposure light of an ArF excimer laser at a transmittance of not less than 2% and not more than 30%, and a function to generate a phase difference of not less than 150 degrees and not more than 200 degrees between the exposure light transmitted through the phase shift film and the exposure light transmitted through air for the same distance as a thickness of the phase shift film,
wherein the phase shift film is formed from a material containing silicon and not substantially containing chromium, and includes a structure in which a lower layer and an upper layer are laminated from the transparent substrate side,
wherein the lower layer has a refractive index n lower than the transparent substrate at a wavelength of the exposure light,
wherein the upper layer has a refractive index n higher than the transparent substrate at a wavelength of the exposure light,
wherein the lower layer has an extinction coefficient k higher than the upper layer at a wavelength of the exposure light,
wherein the light shielding film includes a layer in contact with the phase shift film, and
wherein the layer in contact with the phase shift film is formed from a material containing chromium, has a refractive index n lower than the upper layer at a wavelength of the exposure light, and has an extinction coefficient k higher than the upper layer at a wavelength of the exposure light.
US Pat. No. 10,479,179

METHOD FOR OPERATING A RECHARGEABLE BATTERY CELL AND BATTERY CONTROL DEVICE

Robert Bosch GmbH, Stutt...

1. A method for operating a rechargeable battery cell (2), the method comprising:measuring (101) a first voltage (U1) of the battery cell (2),
comparing (102) the first voltage (U1) with a first limit voltage (Umax1),
charging (104) the battery cell (2) if the first voltage (U1) is less than the first limit voltage (Umax1),
measuring (106) a second voltage (U2) of the battery cell (2),
comparing (107) the second voltage (U2) with a second limit voltage (Umax2),
discharging (109) the battery cell (2) if the second voltage (U2) is greater than the second limit voltage (Umax2),
wherein the first limit voltage (Umax1) is greater than the second limit voltage (Umax2).
US Pat. No. 10,478,411

TREATMENT OF INTRAHEPATIC CHOLESTATIC DISEASES

CymaBay Therapeutics, Inc...

1. A method of treating primary sclerosing cholangitis by administering seladelpar or a salt thereof, where the daily dose of seladelpar or a salt thereof is 5 mg, when the dose is calculated as seladelpar.
US Pat. No. 10,479,950

QUATERNARY AMMONIUM AMIDE AND/OR ESTER SALTS

The Lubrizol Corporation,...

1. A composition comprising a quaternary ammonium salt detergent containing an amide group, where the quaternized detergent comprises the reaction product of:(a) a non-quaternized detergent containing an amide group, where the detergent has a tertiary amine functionality; and
(b) a quaternizing agent;
and wherein the reaction of (a) and (b) is essentially free of any additional acid component other than an acid group present in the structure of the detergent; and wherein (b) the quaternizing agent comprises ethylene oxide, propylene oxide, butylene oxide, styrene oxide, or combinations thereof.
US Pat. No. 10,478,413

DERMAL THERAPEUTIC SYSTEM WITH HIGH ADHESIVITY

FIDIA FARMACEUTICI S.P.A....

1. A dermal therapeutic system which comprises an adhesive polymeric matrix comprisingan acrylate-vinyl acetate copolymer having a Tg below 0° C., which contains free hydroxyl groups, said acrylate-vinyl acetate copolymer being present in a percentage ranging from 45 to 65% by weight with respect to the total dry weight of the adhesive polymeric matrix and a basic butylated methacrylate copolymer, said basic butylated methacrylate copolymer being present in a percentage ranging from 5 to 20% by weight with respect to the total dry weight of the adhesive polymeric matrix, as adhesive components,
an organic or inorganic acid in a percentage ranging from 0.5 to 3.5% by weight with respect to the total dry weight of the adhesive polymeric matrix, as stabilizer,
a salt of Diclofenac in a percentage ranging from 8 to 20% by weight with respect to the total dry weight of the adhesive polymeric matrix, as active principle,
an adhesion modulator in a percentage ranging from 10 to 30% by weight with respect to the total dry weight of the adhesive polymeric matrix, and
the complement to 100 consisting of excipients and/or pharmaceutically acceptable additives,
wherein said dermal therapeutic system does not allow said salt of Diclofenac to exert a systemic action,
wherein the acrylate-vinyl acetate copolymer having a Tg below 0° C., containing free hydroxyl groups, is a self-curing acrylate-vinyl acetate copolymer having a Tg lower than 0° C., containing free hydroxyl groups and without free carboxyl groups or a non-curing acrylate-vinyl acetate copolymer having a Tg lower than 0° C., containing free hydroxyl groups and without free carboxyl groups;
wherein the salt of Diclofenac is selected from the group consisting of alkaline metal salts of Diclofenac, hydroxyethylpyrrolidine salt of Diclofenac, and diethylammonium salt of Diclofenac;
wherein the inorganic acid is hydrochloric acid;
wherein the organic acid is selected from the group consisting of citric acid, succinic acid, lactic acid, maleic acid, fumaric acid, salicylic acid, acetic acid, and a mixture thereof;
wherein the adhesive polymeric matrix has a thickness ranging from 50 to 500 microns and
wherein the dermal therapeutic system has a surface ranging from 20 to 300 cm2.
US Pat. No. 10,479,954

INTRINSIC LOW FRICTION POLYOXYMETHYLENE

Celanese Sales Germany Gm...

1. A polyoxymethylene polymer composition, the polyoxymethylene polymer composition comprising;a polyoxymethylene copolymer having a melt flow index of less than about 50 g/10 min, and
first tribological modifier comprising an ultra-high molecular weight silicone having a kinematic viscosity at 40° C. of greater than 100,000 mm2 s?1, the ultra-high molecular weight silicone being present in the polymer composition in an amount from about 0.1 to about 10% by weight;
a second tribological modifier comprising polytetrafluoroethylene particles, ultra-high molecular weight polyethylene, or a silicone oil having an average molecular weight of at least 5,000 g/mol and less than 75,000 g/mol and having a kinematic viscosity at 40° C. of greater than 100 mm2 s?1 and less than 15,000 mm2 s?1, or mixtures thereof; and
reinforcing fibers present in the composition in an amount of at least 10% by weight and up to 50% by weight.
US Pat. No. 10,478,163

MEDICAL INSTRUMENT ENGAGEMENT PROCESS

Intuitive Surgical Operat...

1. A method for operating a medical instrument and a drive system, the medical instrument comprising at least one component, comprising:bringing a first feature on a rotatable element of the medical instrument into contact with a second feature on a drive element of the drive system without restricting a rotation angle of the first feature relative to the second feature, the second feature being shaped to engage the first feature, and the medical instrument including a mechanism coupled to the rotatable element and coupled to actuate the at least one component of the medical instrument in response to rotation of the rotatable element;
applying an engagement force to create friction between the first and second features, wherein bringing the first feature into contact with the second feature and applying the engagement force engages the first and the second features without inducing rotation that actuates the medical instrument; and
operating the drive system to rotate the drive element and the rotatable element, wherein the friction transfers torque that the drive element applies to the rotatable element to rotate the rotatable element and thereby to actuate the component.
US Pat. No. 10,479,957

LUBRICANT FOR METAL COLD FORMING PROCESSES AND METHODS OF USE OF THE SAME

FREIBORNE INDUSTRIES, INC...

1. A lubricant for use in cold forming of a metal consisting essentially of:one or more lubricating compounds selected from the group consisting of a soap that is a metal salt of a C6 to C22 fatty acid, a soap that is a metal salt of a C6 to C22 fatty acid containing one or more hydroxyl function groups, boric acid, a metal salt of boric acid, boron nitride, zinc oxide, calcium oxide, molybdenum disulfide, an emulsion of polyethylene, an emulsion of high density polyethylene, an emulsion of polypropylene, an emulsion of maleated polypropylene, an emulsion of a urethane, an emulsion of an oxidized polyethylene, an emulsion of an oxidized high density polyethylene, an emulsion of an oxidized polypropylene, an emulsion of an oxidized maleated polypropylene, an emulsion of an oxidized urethane, and mixtures thereof;
one or more starches;
wherein a weight:weight ratio of a total amount of said one or more lubricating compounds to a total amount of said one or more starches in said lubricant is in a range of from 1:1 to 8:1;
optionally, including at least one additional component selected from the group consisting of a surfactant, a corrosion inhibitor, a processing aid, a bactericidal agent, a bacteriostatic agent, a fungistatic agent, a fungicidal agent, a defoaming agent, a viscosity modifier, a pH buffering agent, or mixtures thereof, wherein a total amount of said at least one additional component does not exceed 5% by weight based on a total weight of said lubricant; and
wherein said lubricant is a solid at 75° F.
US Pat. No. 10,477,908

ACRYLIC FIBER FOR ARTIFICIAL HAIR, METHOD FOR PRODUCING SAME, AND HEAD DECORATION PRODUCT COMPRISING SAME

KANEKA CORPORATION, Osak...

1. An acrylic fiber for artificial hair, comprising an acrylic polymer and an organic solvent that can dissolve the acrylic polymer,wherein the acrylic polymer comprises, with respect to a total weight of the acrylic polymer, 29.5 to 79.5% by weight of acrylonitrile, 20 to 70% by weight of vinyl chloride and/or vinylidene chloride, and 0.5 to 5% by weight of a sulfonic acid-containing vinyl monomer,
wherein a content of the organic solvent in the acrylic fiber is 0.1 to 3% by weight, and
wherein the acrylic fiber has a single fiber fineness of 30 to 100 dtex.
US Pat. No. 10,478,422

ORAL LIQUID COMPOSITIONS INCLUDING VALSARTAN

ECI PHARMACEUTICALS, LLC,...

1. An oral liquid solution comprising:3.6 mg/mL to 4.4 mg/mL valsartan or a pharmaceutically acceptable salt or solvate thereof; and
9.3 mg/mL to 10.7 mg/mL citrate salt;
provided that a pH of the oral liquid solution is from 5.8 to 6.1 and the oral liquid solution exhibits a stability for 18 months;
provided that the valsartan or the pharmaceutically acceptable salt or solvate thereof is fully solubilized in the oral liquid solution; and
provided that administration of a 320 mg dose of the oral liquid solution to a patient provides an in vivo plasma profile having a valsartan AUCinf in a range from 35,162 ng*hr/mL to 72,130 ng*hr/m L.
US Pat. No. 10,479,711

COMPOSITION WITH A TIME RELEASE MATERIAL FOR REMOVING HALOGENATED HYDROCARBONS FROM CONTAMINATED ENVIRONMENTS

REMEDIATION PRODUCTS, INC...

1. A remediation composition, comprising:a first set of one or more organisms able to degrade at least one halogenated compound; and
a time release compound, combined with the first set of one or more organisms, comprising:
at least one of a polyamide and a polysaccharide; and
a second set of one or more organisms mixed with the at least one of a polyamide and a polysaccharide, wherein the second set of one or more organisms degrades, over a period of time, the at least one of a polyamide and a polysaccharide into smaller molecules or compounds that donate electrons for use by the first set of one or more organisms during degradation of the halogenated compound and wherein the period of time has a length of at least 20 days,
wherein the remediation composition further comprises a composition comprising activated carbon impregnated with elemental iron, and
wherein the elemental iron is impregnated into the activated carbon by being at least partially dissolved into walls of pores of the activated carbon.
US Pat. No. 10,478,438

TREATMENT OF ORGANOPHOSPHATE EXPOSURE WITH OCINAPLON

1. A method of treating exposure to sarin, comprising the step of administering to a subject in need thereof a therapeutically effective amount of a pharmaceutical composition comprising ocinaplon.
US Pat. No. 10,479,980

ARTIFICIAL OVARY

NORTHWESTERN UNIVERSITY, ...

1. An artificial ovary comprising:a porous three-dimensional scaffold comprising a plurality of overlapping struts, the struts comprising a biocompatible polymer and defining a network of pores; and
a plurality of ovarian follicles disposed inside the pores;
wherein the artificial ovary is capable of supporting at least one of: an ovarian endocrine function; or ovulation of one or more mature oocytes from one or more of the ovarian follicles, when the artificial ovary is cultured in vitro or implanted in a mammalian subject in vivo,
provided that if the biocompatible polymer comprises ovarian extracellular matrix, then that ovarian extracellular matrix comprises processed decellularized ovarian extracellular matrix.
US Pat. No. 10,479,992

RNA DUPLEXES WITH SINGLE STRANDED PHOSPHOROTHIOATE NUCLEOTIDE REGIONS FOR ADDITIONAL FUNCTIONALITY

Phio Pharmaceuticals Corp...

1. An isolated double stranded nucleic acid molecule comprising a guide strand and a passenger strand, wherein the passenger strand is 8-16 continuous nucleotides in length, wherein the isolated double stranded nucleic acid molecule comprises a double stranded region that is 8-16 nucleotides in length, wherein the guide strand is 19-25 nucleotides in length, and wherein the double stranded region is connected through a cleavable chemical linker to a single stranded region of at least six phosphorothioate modified nucleotides.
US Pat. No. 10,478,463

EXTERNAL-USE MEDICAMENT FOR CLEANING AND CARE OF THE OVARIES, VAGINA, AND VULVA

1. An external-use composition effective for cleaning and caring for ovaries, vagina and vulva, wherein the external-use composition effectively inhibits or prevents repeated infection of the ovaries, the composition comprising therapeutically effective amounts of the following, by parts by weight of the composition:propolis extract in an amount of 1 to 10 parts by weight,
zedoary oil in an amount of 5 to 10 parts by weight, and
mint leaf filtrate in an amount of 50 to 100 parts by weight,
wherein the external-use composition is a medical liquid composition prepared by a method comprising:
preparing the propolis extract, including: loading raw propolis into a CO2 extraction tank and circularly adding CO2 liquid to perform extraction with an extraction temperature of 15 to 30° C., an extraction pressure of 8 to 10 MPa, and extraction time of 1 to 2 hours, to obtain the propolis extract, a propolis content of which is 1% to 3% of amount of the raw propolis;
preparing the zedoary oil, including: directly loading zedoary seeds into a CO2 extraction tank and circularly adding CO2 liquid to perform extraction with an extraction temperature of 20 to 30° C., an extraction pressure of 2 to 7 MPa, and extraction time of 1 to 2 hours, to obtain zedoary oil extract containing a plant zedoary ketone ingredient;
preparing the mint leaf filtrate, including: mixing fresh mint leafs with pure water in a weight ratio of 1:2 to 1:3, breaking the fresh mint leafs in water mechanically into pieces, adding medical ethanol of 0.1 to 0.2 times by weight, soaking for 10 to 15 hours, and filtrating with a 200 mesh screen to remove precipitates to obtain the mint leaf filtrate;
dissolving the propolis extract, the zedoary oil extract and the mint leaf filtrate, in accordance with requirements of the formula composition, into medical ethanol of 0.1 to 0.3 times by weight of the active ingredients, and mixing them, and then removing by freezing and centrifugation, precipitates under the following conditions: at a frozen temperature of 0° C. to 4° C. and at a centrifugal rotation speed of 3000 rpm to 4000 rpm, for a duration of 10 to 20 minutes, and then separating centrifugate by an acoustic membrane separator to obtain a medical liquid with a molecular weight less than 10000D,
obtaining the external-use composition, and
optionally bottling or bagging the external-use composition.
US Pat. No. 10,480,002

ALGAL BASED EDIBLE VACCINES

TRANSALGAE ISRAEL LTD., ...

1. An edible vaccine comprising a transgenic eukaryotic microalga, the transgenic microalga comprising an expression cassette comprising at least one polynucleotide encoding an exogenous antigen further comprising a polynucleotide encoding a vacuolar targeting peptide having the amino acid sequence set forth in any one of SEQ ID NO:1 and SEQ ID NO:9, wherein the encoded exogenous antigen is localized within the vacuole of the microalga cell, and wherein said encoded exogenous antigen induces an immune response in a target subject consuming said vaccine against a disease caused by a pathogen.
US Pat. No. 10,480,003

CONSTRUCTS AND SYSTEMS AND METHODS FOR ENGINEERING A CO2 FIXING PHOTORESPIRATORY BY-PASS PATHWAY

THE REGENTS OF THE UNIVER...

1. A recombinant host cell comprising heterologously expressed genes mcr, mcl, mch, mct, meh, and pcs, and a second heterologously expressed mct gene, and wherein the recombinant host cell does not naturally express the heterologously expressed genes and wherein the host cell produces a synthetic photorespiratory bypass pathway.
US Pat. No. 10,478,475

USE OF VON WILLEBRAND FACTOR

LABORATOIRE FRANCAIS DU F...

1. A method of treating or preventing haemorrhage and/or bleeding in patients with mechanical circulatory support, comprising administering to the patient a pharmaceutical composition comprising von Willebrand factor in an amount effective for treating or preventing haemorrhage and/or bleeding in patients with mechanical circulatory support, wherein the composition contains a residual amount of factor VIII less than or equal to 10 IU/100 IU VWF:RCo, and wherein the composition is administered to the patient at a dose of 45 IU/kg to 55 IU/kg of body weight.
US Pat. No. 10,479,757

N,N-DIMETHYLAMINOETHYL ACRYLATE COMPOSITION STABILIZED IN RESPECT OF DISCOLORING EFFECTS

Arkema France, Colombes ...

1. A process for the continuous production of a composition of N,N-dimethylaminoethyl acrylate that is stabilized with respect to coloration, comprising from 25 to 200 ppm of 2,6-di-tert-butyl-4-methylphenol, said process comprising the steps of transesterifying a light acrylate selected from the group consisting of methyl acrylate and ethyl acrylate, with dimethylaminoethanol in the presence of a catalyst, followed by a treatment for purifying a reaction mixture comprising a final distillation of purified N,N-dimethylaminoethyl acrylate, wherein 25 to 200 ppm of 2,6-di-tert-butyl-4-methylphenol are introduced at an outlet of the distilled gaseous stream of purified N,N-dimethylaminoethyl acrylate, before condensation of final product.
US Pat. No. 10,480,013

INFLUENZA VIRUS VECTOR FOR VIROTHERAPY

BLUE SKY VACCINES GMBH, ...

1. A recombinant influenza B virus vector comprising an NS gene encoding a truncated NS1 protein consisting of 106 amino acids of the N-terminus of the respective wild type NS1 protein, wherein the vector:(i) replicates in IFN-sensitive tumor cells and in IFN-resistant tumor cells, and is attenuated in normal cells, and
(ii) expresses a heterologous immunostimulatory polypeptide, wherein the heterologous polypeptide is a tumor associated antigen.
US Pat. No. 10,478,476

USE OF FULL-LENGTH AMELOGENIN FOR PROMOTING NERVE GROWTH OR REGENERATION

Hadasit Medical Research ...

1. A method of promoting nerve growth or regeneration in a subject in need thereof, the method comprising directly administering to an injured nerve of the subject a therapeutically effective amount of full-length amelogenin, thereby promoting nerve growth or regeneration in the subject, wherein said injured nerve is a peripheral or a spinal cord nerve.
US Pat. No. 10,479,758

HAFNIUM-BASED METAL-ORGANIC FRAMEWORKS AS EPOXIDE RING-OPENING CATALYSTS

NORTHWESTERN UNIVERSITY, ...

1. A metal-organic framework comprising:inorganic nodes that comprise an octahedral Hf6 cluster capped by eight ?3-ligands and having twelve octahedral edges, wherein the ?3-ligands are hydroxo ligands, oxo ligands or aquo ligands; and
organic linkers connecting the organic nodes, the organic linkers comprising 1,3,6,8-tetrakis(p-benzoic acid)pyrene units; wherein eight of the twelve octahedral edges of the inorganic nodes are connected to the 1,3,6,8-tetrakis(p-benzoic acid)pyrene units.
US Pat. No. 10,480,014

METHOD FOR PRODUCING NATURAL RUBBER BY USING RECOMBINANT MICROORGANISM

AJOU University Industry-...

1. A method for producing natural rubber by using a recombinant microorganism, comprising the steps of:(a) constructing an expression vector capable of expressing a gene encoding for cis-prenyltransferase, which is a guayule-derived natural rubber synthase having the amino acid sequence of SEQ ID NO: 2 or a Hevea brasiliensis-derived natural rubber synthase having the amino acid sequence of SEQ ID NO: 6, and an expression vector capable of expressing a gene encoding for an E. coli-derived UDP pyrophosphate synthase having the amino acid sequence of SEQ ID NO: 4;
(b) transforming the expression vectors into a host microorganism;
(c) culturing the transformed host microorganism; and
(d) isolating natural rubber from a culture of the transformed host microorganism.
US Pat. No. 10,480,015

METABOLIC ENGINEERING FOR MICROBIAL PRODUCTION OF TERPENOID PRODUCTS

MANUS BIO INC., Cambridg...

1. A method for production of a terpene or terpenoid product, comprising:providing an E. coli bacterial strain that produces isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) through an upstream methylerythritol phosphate pathway (MEP pathway) and converts the IPP and DMAPP to a terpene or terpenoid product through a recombinant downstream synthesis pathway;
wherein IspG and IspH enzymes are overexpressed in the bacterial strain by complementation with recombinant ispG and ispH genes, such that IspH activity is higher than IspG activity to provide increased carbon flux to 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) intermediate, while preventing accumulation of HMBPP at an amount that feeds back and reduces MEP pathway flux and terpene or terpenoid productivity; the strain comprising a recombinant pyruvate:flavodoxin oxidoreductase (PFOR) enhancing supply and/or transfer of electrons through the MEP pathway and/or to terpene and terpenoid products, and culturing the bacterial strain to produce the terpene or terpenoid product.
US Pat. No. 10,480,016

GENETICALLY ENGINEERED MICROORGANISMS FOR BIOLOGICAL OXIDATION OF HYDROCARBONS

Calysta, Inc., Menlo Par...

1. A non-naturally occurring bacterium, comprising:a host methanotrophic bacterium having an exogenous nucleic acid encoding an enzyme with methane monooxygenase (MMO) activity,
wherein the MMO comprises an amino acid sequence having at least 90% identity to the amino acid sequence of any one of SEQ ID NOS: 99-102, 174, 197, and 649-653;
wherein at least one alcohol dehydrogenase enzyme is inactivated in the non-naturally occurring bacterium as compared to the host methanotrophic bacterium; and
wherein the non-naturally occurring bacterium is capable of converting methane into methanol.
US Pat. No. 10,480,017

PROCESS FOR USING BIOGENIC CARBON DIOXIDE DERIVED FROM NON-FOSSIL ORGANIC MATERIAL

Iogen Corporation, Ottaw...

1. A process for producing a fuel or fuel intermediate containing carbon derived from non-fossil organic material comprising:(i) providing biogenic carbon dioxide that is sourced from a production process comprising at least one of a step of fermentation and a thermal process, said production process producing a first product derived from the non-fossil organic material, said first product selected from: (a) an energy product; (b) a biogenic carbon-based product selected from a chemical product, a fuel and a fuel intermediate; and (c) a combination thereof, wherein the biogenic carbon dioxide is generated during the production process;
(ii) providing a stream enriched in hydrogen that is sourced from a hydrogen production process, the hydrogen production process including a step of removing fossil carbon dioxide from a stream including hydrogen to provide the steam enriched in hydrogen;
(iii) converting the biogenic carbon dioxide and hydrogen from the enriched hydrogen stream to a second product, said second product comprising at least one of a biogenic carbon-based fuel and a biogenic carbon-based fuel intermediate; and
(iv) carrying out or arranging for one or more parties to carry out at least one step that contributes to a reduction in the life cycle greenhouse gas (GHG) emissions of the second product.
US Pat. No. 10,478,480

PEPTIDES AND COMBINATION OF PEPTIDES FOR USE IN IMMUNOTHERAPY AGAINST PROSTATE CANCER AND OTHER CANCERS

IMMATICS BIOTECHNOLOGIES ...

1. A method of eliciting an immune response in a patient who has cancer, comprising administering to said patient a population of activated T cells that kill cancer cells that present a peptide consisting of the amino acid sequence of GYLQGLVSF (SEQ ID NO: 27),wherein said cancer is selected from liver cancer, benign prostate hyperplasia, and prostate cancer.
US Pat. No. 10,480,019

PROCESS FOR PRODUCING HIGH-PURITY RUBUSOSIDE

PureCircle Sdn Bhd, Kual...

1. A process for preparing Rubusoside from steviol glycosides of Stevia rebaudiana comprising the steps of:A) providing a solution comprising Stevioside;
B) adding 2000 fungal ?-glucanase (FBG) units of an enzyme composition having fungal ?-glucanase activity to the solution comprising Stevioside to obtain a reaction mixture; and
C) incubating the reaction mixture at 28-50° C. for 12-48 hours to facilitate transformation of Stevioside to Rubusoside to obtain a reaction mixture containing Rubusoside.
US Pat. No. 10,480,278

CEMENT SPACER FLUID COMPRISING QUATERNARY SURFACTANT, VISCOSIFIER, AND PROPPANT

BAKER HUGHES, A GE COMPAN...

1. A method of cementing a wellbore penetrating a subterranean formation, the method comprising:injecting into the wellbore a cement spacer fluid comprising a carrier fluid, a quaternary surfactant, a viscosifier, and a proppant;
injecting a cement slurry into the wellbore; and
allowing the cement slurry to set,
wherein the carrier fluid comprises water;
the proppant comprises ceramic particles, sand, a nut shell, gravel, glass, or a combination comprising at least one of the foregoing;
the quaternary surfactant has a cation of R1 R2 R3 R4N+ and an anion, wherein R1, R2, R3 and R4 are each independently a straight or branched C1-30 alkyl group, a C7-30 alkylbenzyl group, a C7-30 arylalkyl group, a straight or branched C3-30 alkenyl group, a C1-30 hydroxyalkyl group, a C7-30 hydroxyalkylbenzyl group, or a polyoxyalkylene group; and the anion comprises a halide, a perchlorate, a thiocyanate, a cyanate, a carboxylate, an alkyl sulfate, an alkyl sulfonate, PF6?, AsF6?, SbF6?, NO2?, NO3?, SO4?, or BX4?, wherein X is a halide;
the viscosifier comprises guar gums, guar derivatives, hydratable polysaccharides, xanthan gum, galactomannan gums, glucomannan gums, cellulose, cellulose derivatives, poly((meth)acrylic acid)s, poly((meth)acrylamides), copolymers of (meth)acrylic acid and (meth)acrylamide, C1-8 alkyl poly(meth)acrylates, clays, or a combination comprising at least one of the foregoing viscosifiers; and
the cement spacer fluid comprises about 30 to about 100 wt % of the carrier fluid, about 0.05 to about 10 wt % of the quaternary surfactant, about 0.05 to about 10 wt % of the viscosifier, and about 1 to about 65 wt % of the proppant, each based on the weight of water in the cement spacer fluid.
US Pat. No. 10,478,484

GNA1870-BASED VESICLE VACCINES FOR BROAD SPECTRUM PROTECTION AGAINST DISEASES CAUSED BY NEISSERIA MENINGITIDIS

1. A composition comprising:isolated antigenic vesicles prepared from a Neisseria meningitidis (N. meningitidis) genetically modified to disrupt production of the endogenous GNA1870 polypeptide so that the endogenous GNA1870 is not present at detectable levels in the isolated antigenic vesicles and to overexpress at least one full length meningococcal GNA1870 polypeptide at a level sufficient to provide for production of the isolated antigenic vesicles that, when administered to a mammalian subject elicit anti-meningococcal GNA1870 polypeptide antibodies,
wherein the overexpressed GNA1870 polypeptide is a meningococcal variant 1, a variant 2 GNA1870 polypeptide, or a variant 3 GNA1870 polypeptide heterologous to the N. meningitidis,
wherein the isolated antigenic vesicles are outer membrane vesicles (OMVs), microvesicles (MVs), or a mixture of the OMVs and the MVs, and
wherein the N. meningitidis is genetically modified to provide for decreased toxic activity of its lipid A relative to its parental unmodified N. meningitidis; and
a pharmaceutically acceptable carrier.
US Pat. No. 10,480,022

SPATIALLY ENCODED BIOLOGICAL ASSAYS

Prognosys Biosciences, In...

1. A method for determining a spatial location of a biological molecule of a tissue sample comprising(a) providing a plurality of beads, wherein the plurality of beads comprise a plurality of binding agents, wherein a binding agent of the plurality of binding agents (i) comprises a coding identifier having a nucleic acid sequence and (ii) is configured to interact with a biological molecule of a tissue sample, wherein the coding identifier corresponds to a location at which the binding agent interacts with a biological molecule of a tissue sample;
(b) contacting the plurality of beads with the tissue sample such that the binding agent interacts with the biological molecule; and
(c) using the coding identifier to identify the location where the binding agent interacted with the biological molecule, thereby determining a spatial location of the biological molecule of the tissue sample.