US Pat. No. 10,427,028

TILES ON SHAPES PUZZLE GAME

1. A tile-on-shape puzzle game comprising:at least one tile, wherein the at least one tile is either a first tile design or a second tile design;
wherein the first tile design further comprises:
an upper face;
a plurality of edges, where the plurality of edges is at least three linear edges, curved edges, or combination of linear edges and curved edges;
a lower face;
a play indicia disposed on the upper face;
wherein the second tile design further comprises:
an upper face;
a plurality of edges, where the plurality of edges is at least three linear edges, curved edges, or combination of linear edges and curved edges;
a lower face;
a play indicia disposed on the upper face;
at least one projection extending from the lower face;
a plurality of playing shapes, further comprising:
a shape surface having a first face and a second face;
a plurality of shape edges, where the plurality of shape edges is at least three linear edges, circumferential edges, or combination of linear edges and circumferential edges;
a plurality of sides, wherein the plurality of sides have a width smaller than the width of the first face;
at least one recess disposed on the first face, wherein the recess is complementary to the at least one tile of the first tile design or a projection extending from the at least one tile of the second tile design;
wherein the at least one recess has at least three linear edges, octagonal edges, circumferential edges, or combination of linear edges and circumferential edges;
wherein the at least one recess is dimensioned such that the at least one tile or the projection extending from the at least one tile is accepted within the at least one recess; and
at least one inverse tile recess disposed on the second face of the playing shapes and corresponding to the inverse location of the at least one recess on the at least one shape disposed on the first face;
wherein the at least one inverse tile recess has at least three linear edges, octagonal edges, circumferential edges, or combination of linear edges and circumferential edges;
wherein at least two of the edges of the recess are parallel to each other; and
wherein the at least one inverse recess is dimensioned such that the at least one tile or the projection extending from the at least one tile is accepted within the at least one inverse tile recess.

US Pat. No. 10,427,027

CASINO TABLE GAME APPARATUS AND METHOD

1. A method of playing a dice game comprising:providing a dice cup with a flat base and substantially flat upper surface to the base;
providing a first pair of cubic dice with first and second die, with the first and second die of the first pair of cubic dice each having six flat sides and eight corresponding corners and each flat side of the first and second die having a marking to indicate a unique integer value from one to six;
providing a second pair of cubic bonus dice with first and second die, with the first and second die of the second pair of cubic bonus dice each having six flat sides and eight corresponding corners, the first die having five flat sides with no markings and one flat side with a “Y” marking, and the second die having five flat sides with no markings and one flat side with a “O” marking;
providing a designated game surface identified as a gaming layout or a dice landing tray with six designated point areas and corresponding markings for the numbers 4, 5, 6, 8, 9, and 10;
providing a dealer; and
providing at least one player;
wherein the method comprising the steps of:
(a) placing a play wager by each player;
(b) presenting the dice cup containing the first pair of cubic dice and the second pair of cubic bonus dice from the dealer to one player designated as a shooter;
(c) use of the dice cup by the shooter, prior to establishment of a number comparison point, to make a pre-point roll of the first pair of cubic dice and the second pair of cubic bonus dice on the designated surface at the same time;
(d) in response to the pre-point roll:
(i) recognizing a win and making a predetermined payout on each play whereby if the integers showing on upper sides of the first pair of cubic dice totals (11);
(ii) recognizing a tie for each play wager if the integers showing on upper sides of the first pair of cubic dice totals (7); and
(iii) recognizing a loss on and collecting each play wager if the integers showing on upper sides of the first pair of cubic dice total (2), (3) or (12); or
(iv) establishing the number comparison point for subsequent wagering and dice rolls if the integers showing on upper sides of the first pair of cubic dice total (4), (5), (6), (8), (9), or (10), and with the number comparison point corresponding to the integer total and the dealer denoting the established number comparison point with a marker on the corresponding designated area of the designated surface;
(e) repeating steps a-c until a number comparison point is established consistent with step (d)(iv);
(f) after a point is established, placing a late play wager by any new player and placing a bonus wager by any player who placed a play wager at step (a);
(g) use of the dice cup by the shooter to make a post-point roll of the first pair of cubic dice and the second pair of cubic bonus dice on the designated surface at the same time;
(h) in response to the post-point roll:
(i) repeating the post-point roll if the integers showing on upper sides of the first pair of cubic dice do not total the point or (7);
(ii) recognizing and making a predetermined payout on each play wager and each late pay wager if the integers showing on upper sides of the first pair of cubic dice total the point; or
(iii) recognizing a loss on and collecting each play wager if the integers showing on upper sides of the first pair of cubic dice total (7); and
(i) in response to each post-point roll:
(i) recognizing a loss on and collecting each bonus wager if the integers showing on upper sides of the first pair of cubic dice total (7) and the markings on upper sides of the second pair of cubic bonus dice are any combination other than the “Y” on the first die having the “Y” marking and the “O” on the second die having the “O” marking; or
(ii) recognizing and making a predetermined payout on each bonus wager on each dice roll after the point is established if the markings on upper sides of the second pair of cubic bonus dice are the “Y” on the first die having the “Y” marking and the “O” on the second die having the “O” marking.

US Pat. No. 10,427,026

LONGBOARD-SKATEBOARD AND LONGBOARD-SKATEBOARD CONVERSION KIT

1. A structural support member for a conventional snowboard for converting the conventional snowboard to a longboard-skateboard comprising:providing a conventional snowboard having a substantially flat deck; and
said deck having a length to width ratio of 6.15 to 1; and
said deck having a deck long-axis; and
said deck comprising an upper surface and a substantially flat lower surface; and
said deck further comprising a front portion, a rear portion and a middle portion; and
a single substantially linear structural member, comprising:
a length to width ratio of 14 to 1; and
a structural-member long-axis; and
a first end and a second end at each end of said long axis; and
both first and second end being between 0.375 and 0.75 of the thickness of the majority of the substantially linear member; and
said substantially linear member fixedly engaged with said deck substantially flat lower surface with said deck long-axis collinear with said structural-member long-axis; and
providing a first skateboard truck assembly and a second skateboard truck assembly; and
said first truck assembly mounted on said deck substantially flat lower surface, proximal to said deck front portion; and
said second truck assembly mounted on said deck substantially flat lower surface, proximal to said deck rear portion; anda conventional snowboard is converted to a skateboard as said substantially linear member provides sufficient structure to prevent excessive flexion of the deck such that the lower portion of the deck does not contact a surface over which the truck assemblies are in contact with; and wherein said substantially linear member returns to its original shape after being flexed.

US Pat. No. 10,427,025

SKI TOTE

Brian Greenfield, Quebec...

1. A ski tote comprising:a short strap;
a snap clasp containing at least two elements, one element being fastened to one end of the short strap and another element being fastened toward the other end of the short strap with an adjusting piece of the short strap beyond the other element; and
a long strap longer than the short strap, with one end fastened to the short strap just inside of and immediately adjacent to one of the clasp elements and the other end fastened to the short strap just inside of the other of the clasp elements, the portion of the long strap between its attachments to the short strap being a continuous one-piece portion;
whereby the short strap can be placed about a pair of skis and locked there by engaging the clasp elements, the adjusting piece can be pulled to make the attachment about the skis snug and the long strap can be used for carrying the skis such that the claps elements may face away from the long strap.

US Pat. No. 10,427,024

MECHANICALLY PROPELLED SNOWBOARD

1. A mechanically propelled snowboard comprising:a board;
a frame coupled to the board and extending from an upper face of the board proximate to a tail section of the board;
a pair of bindings coupled to the upper face of the board wherein each binding is configured for coupling to a respective foot of a user for coupling the user to the board;
a propulsion assembly coupled to the frame, the propulsion assembly comprising:
an engine,
a pair of wheels, a respective wheel being operationally coupled to the engine, and
an endless track operationally coupled to the pair of wheels such that a lower limit of the endless track is substantially coplanar with a lower face of the board wherein the engine is positioned for selectively rotating the endless track concurrently with the respective wheel for propelling the board and the user along a surface;
a controller operationally coupled to the engine wherein the controller is positioned for selectively throttling, braking, and shifting the engine; and
the frame comprising
a pair of first plates coupled to the board and extending from the upper face of the board proximate to the tail section of the board;
a slot positioned in the tail section;
a pair of bars, each bar being coupled to and extending from a respective first plate through the slot such that the bar is substantially parallel to the lower face of the board; and
an engine mount coupled to and extending between the bars.

US Pat. No. 10,427,023

SHOULDER PADS AND METHOD OF MANUFACTURING THE SAME

BSN SPORTS, LLC, Farmers...

1. Shoulder pads, comprising:a left torso pad and a right torso pad, each of the left and right torso pads including a chest portion, a back portion, and an arch portion, wherein each arch portion extends from a first end thereof to a second end thereof that is opposite of the first end;
wherein the first end of each arch portion is pivotably connected to the respective chest portion by a first fastener extending at least partially within a first opening in the arch portion, the first fastener being configured for movement relative to the first opening,
wherein the second end of each arch portion is pivotably connected to the respective back portion by a second fastener extending at least partially within a second opening in the arch portion, the second fastener being configured for movement relative to the second opening, and
wherein each arch portion is configured to rotate independently of the respective chest and back portions via the pivotable connections of the arch portion.

US Pat. No. 10,427,022

STRIKING ASSEMBLY

BIG HIT HOLDINGS INC., T...

1. A striking assembly for martial arts training comprising:a base plate having a first side and a second side opposite the first side, the base plate configured to be secured to a substrate external to the striking assembly;
a support unit comprising:
a support plate having a third side and a fourth side opposite the third side, the support plate coupled to the base plate and disposed such that the third side of the support plate is proximal to and faces the second side of the base plate; and
a post secured to the support plate, the post extending from the fourth side of the support plate in a direction away from the fourth side;
a striking unit comprising a main body having a recess for receiving a portion of the post of the support unit, the main body reversibly securable to the post, and a striking pad covering at least a portion of the main body, the striking pad configured to receive striking impacts;
three or more isolators coupling the support plate to the base plate, each isolator having a body being resiliently deformable, a first end of each isolator connected to the second side of the base plate, and a second end of each isolator connected to the third side of the support plate, the three or more isolators spaced such that one isolator is out of line with the other two isolators, the isolators resiliently deformable in response to a force originating from the striking impacts;
wherein in response to at least one of the striking impacts:
when the force is being applied during the at least one striking impact, the isolators are configured to resiliently deform in response to the force such that the striking unit and the support unit reversibly deflect relative to the base plate to create a deflection angle between a normal to the support plate and a normal to the base plate; and
when the force is discontinued at a conclusion of the at least one striking impact, the isolators are configured to resiliently return substantially to their undeformed dimensions to cause the striking unit and the support unit to rebound such that the normal to the support plate returns to being substantially parallel to the normal to the base plate.

US Pat. No. 10,427,021

COMBAT TRAINING DEVICE

1. A combat training device comprising:an elongated support having a rearward end, a forward end and a sleeve housing, the sleeve housing including a longitudinal bore;
the elongated support having a shoulder rest at the rearward end of the elongated support;
the elongated support having a socket at the forward end of the elongated support and a neck support removably engaged with the socket;
a punching target connected to the neck support; and
a punching member mounted to a forward end of a reciprocating support and longitudinally moveable relative to the punching target, the reciprocating support slidably disposed within the longitudinal bore of the sleeve housing.

US Pat. No. 10,427,020

BASKETBALL SHOT TRAINING DEVICE

1. A training device for training a player to shoot a basketball, the device comprising:a plate member configured to engage at least a portion of a hand and wrist of a non-shooting hand of the player;
at least one attachment member connected to the plate member and configured to secure the plate member to the non-shooting hand of the player;
a link strap connected at a first end to the plate member and having an aperture through which a wrist of a shooting hand of the player can be aligned;
wherein the plate member includes a main portion and a thumb portion extending from the main portion, and wherein the at least one attachment member includes a thumb strap configured to secure a thumb of the non-shooting hand to the plate member such that movement of the thumb relative to the plate member is restricted;
whereby the non-shooting hand and the shooting hand are linked together such that the non-shooting hand is restricted from rotation relative to the shooting hand when the non-shooting hand and the shooting hand are placed in spaced relation on an associated basketball.

US Pat. No. 10,427,019

MULTI-FUNCTIONAL THROWING GAME BOARD

David L. Schmidt, Zimmer...

1. A throwing game comprising:a panel assembly including:
a support frame;
a first panel and a second panel supported by the support frame, the first panel having an aperture through a first major surface, the first panel and the second panel being supported by the support frame in two configurations:
a first configuration wherein the first panel extends from the support frame forming a platform with a free end and wherein a second major surface of the second panel is disposed above the first major surface and is oblique or perpendicular to the first major surface, and
a second configuration wherein the first major surface of the first panel is coplanar with the second major surface of the second panel and wherein the first panel and second panel are adjustably spaced apart to vary a gap formed between side edges of the first major surface and the second major surface that face each other; and
a panel assembly support connected to the panel assembly to support at least one end of the panel assembly off a ground surface.

US Pat. No. 10,427,018

GOLF CLUB HEAD WITH SOUND DAMPING

TAYLOR MADE GOLF COMPANY,...

1. A golf club head comprising:a face portion surrounded by a topline portion, a toe portion, a sole portion and a heel portion, the face portion comprising a front striking surface and a back surface;
a backbar portion extending upwardly from the sole portion behind the face portion;
a rear cavity located behind the face portion and defined by inner peripheral walls of the topline portion, the toe portion, the sole portion, and the heel portion; and
a badge coupled to the back surface of the face portion, the badge comprising a main body portion and at least one structural member extending outwardly from the main body portion, wherein the at least one structural member comprises an upper portion and a lower portion disposed between the topline portion and the sole portion, and wherein the at least one structural member has a maximum height above the main body portion in the range of 8 to 20 millimeters (mm) at the lower portion and a minimum height in the range of 2 to 8 mm at the upper portion;
wherein:
the badge is disposed within the rear cavity;
the main body portion of the badge further comprises a toe-side peripheral edge that is sized and shaped to conform to an inner peripheral wall of the toe portion;
the main body portion of badge further comprises a heel-side peripheral edge that is sized and shaped to conform to an inner peripheral wall of the heel portion;
the backbar portion includes at least one recess configured to receive the lower portion of the at least one structural member of the badge and a damping material; and
the damping material is disposed within the at least one recess of the backbar portion and between the lower portion of the at least one structural member of the badge and the backbar portion.

US Pat. No. 10,427,017

SYSTEM AND METHOD FOR MONITORING PERFORMANCE CHARACTERISTICS ASSOCIATED WITH USER ACTIVITIES INVOLVING SWINGING INSTRUMENTS

Arccos Golf LLC, Stamfor...

1. A sensor module adapted to be operatively coupled to a golf club and configured to detect a golf swing or an impact between the golf club and an object, the sensor module comprising:a power source configured to power the sensor module;
an inertial sensor operatively coupled to the power source and configured to output one or more electrical signals that correspond to a gravitational force sensed by the inertial sensor along a z-axis, the gravitational force sensed by the inertial sensor having a sensed magnitude and a sensed directional component; and
control circuitry operatively coupled to the power source, the inertial sensor, and the memory, the control circuitry including a processing device being configured to transition between a plurality of modes of operation to control power consumed by the processing device based one whether the sensed magnitude represented by the one or more electrical signals output by the inertial sensor is between a minimum threshold magnitude and a maximum threshold magnitude and whether the sensed directional component represented by the one or more electrical signals conforming to a specified directional component.

US Pat. No. 10,427,016

GOLF CLUB TRACKING SYSTEM

1. A golf club tracking system for tracking the removal and replacement of golf clubs relative to a golf bag by a golfer, the golf club tracking system comprising:one or more golf club tags associated with one or more of the golf clubs such that the one or more golf club tags are located on the golf clubs and including a golf club tag housing and a golf club transmitter located within the golf club tag housing;
a golfer tag associated with the golfer such that the golfer tag is located on the golfer and including a golfer tag housing and a golfer transmitter located within the golfer tag housing;
a base detector associated with the golf bag including a processor in electronic communication with an antenna for detecting a signal of at least one of the golf club transmitters and the golfer transmitter to determine proximity of the one or more golf club tags and the golfer tag with the base detector;
wherein when the golfer tag is determined to be within proximity of the base detector based a signal of the golfer transmitter detected on the base detector, the one or more golf club tags are inventoried by determining a number of golf club tags in proximity to the base detector based on signals from the golf club transmitters of the one or more golf club tags being detected on the antenna of the base detector to indicate that the one or more golf clubs are therefore within the golf bag; and
wherein when fewer than all of the one or more golf club tags are detected by the base detector when the golfer tag is determined to be within proximity to the base detector, one of the base detector and golfer tag generates an alert.

US Pat. No. 10,427,015

ADJUSTABLE LOFT GOLF CLUB HEAD

Ringertown Innovations, L...

1. A golf club head for use with a golf club shaft, the golf club head comprising:a housing component comprising a toe, a heel, a center portion connecting the toe and the heel, and a sole extending along a bottom surface of the housing component between the toe and the heel;
a face component comprising a blade and a housing component engaging portion attached to the blade and the housing component, wherein a loft of the blade in relation to the golf club shaft is adjustable; and
a plurality of adjusting components insertable into the housing component through the sole for engaging and repositioning the housing component engaging portion of the face component to adjust the loft of the blade by pushing a bottom of the blade away from the housing component; and
a securing component comprising a threaded end and a tightening end for securing the face component to the housing component once the loft is adjusted; and
wherein the toe comprises a toe hole extending laterally through at least a portion of the toe dimensioned to receive the securing component.

US Pat. No. 10,427,014

GOLF CLUB

Taylor Made Golf Company,...

1. A golf club head for an iron-type club, the golf club head comprising:a cavity-back iron-type body including a heel portion, a sole portion, a toe portion, a top-line portion, and a face portion, wherein the sole portion extends rearwardly from a lower end of the face portion and the body defines an open cavity behind the face portion;
wherein the face portion includes an ideal striking location that defines the origin of a coordinate system in which an x-axis is tangential to the face portion at the ideal striking location and is parallel to a ground plane when the body is in a normal address position, a y-axis extends perpendicular to the x-axis and is also parallel to the ground plane, and a z-axis extends perpendicular to the ground plane, wherein a positive x-axis extends toward the heel portion from the origin, a positive y-axis extends rearwardly from the origin, and a positive z-axis extends upwardly from the origin;
wherein the club head includes a central region in which ?25 mm wherein at least one face channel is defined in the face portion in a location outside of the central region and proximate to at least one of the toe portion, heel portion and top line portion, the at least one channel being defined through an entire thickness of the face portion;
wherein at least one sole channel is defined in the sole portion, the at least one sole channel being defined through an entire thickness of the sole portion into the open cavity of the golf club head;
wherein a damper is included in the open cavity of the golf club head, wherein the damper does not extend over the at least one face channel; and
wherein at least one point on the face having an x-axis coordinate of ?30 mm has a contact time that is at most 130 microseconds less than a contact time at the ideal striking location.

US Pat. No. 10,427,013

GOLF CLUB HEAD OR OTHER BALL STRIKING DEVICE WITH FACE HAVING MODULUS VARIANCE

Karsten Manufacturing Cor...

1. An iron-type golf club head, comprising:a top portion;
a sole portion opposite the top portion;
a heel portion;
a toe portion opposite the heel portion;
a front portion including a ball striking surface and an inner surface opposite the ball striking surface;
an insert that is integral to the front portion;
a rear cavity opposite the front portion;
wherein the insert comprises a plurality of layers that extends from a portion of the ball striking surface to a portion of the inner surface, such that each layer thereof comprises a different modulus,
wherein the plurality of layers include a first layer, a second layer, a third layer, and a fourth layer, and
wherein the first layer has the highest modulus followed by the second layer, the third layer, and the fourth layer.

US Pat. No. 10,427,012

GOLF CLUB HEADS WITH RIBS AND RELATED METHODS

Karsten Manufacturing Cor...

1. A golf club head comprising:a body comprising:
a heel end, a toe end, a crown, a sole, a front wall comprising a strikeface, and a rear side;
an interior surface defined by the heel end, the toe end, the crown, the sole, the front wall, and the rear side; and
an interior cavity bounded by the interior surface;
and
ribs protruded from a rib surface of the body;
wherein:
the ribs comprise:
a first rib comprising:
a first first-rib endpoint;
a second first-rib endpoint; and
a first rib axis intersecting the first and second first-rib endpoints;
a first rib length, a first rib width, and a first rib height; wherein:
 the first rib length extends from the first first-rib endpoint to the second first-rib endpoint;
 the first rib width is substantially parallel to the rib surface and substantially orthogonal to the first rib length; and
 the first rib height is substantially orthogonal to the rib surface; and
a second rib comprising:
a first second-rib endpoint;
a second second-rib endpoint; and
a second rib axis intersecting the first and second second-rib endpoints;
a second rib length, a second rib width, and a second rib height; wherein:
 the second rib length extends from the first second-rib endpoint to the second second-rib endpoint;
 the second rib width is substantially parallel to the rib surface and substantially orthogonal to the second rib length; and
the second rib height is substantially orthogonal to the rib surface; and
a third rib comprising:
a first third-rib endpoint;
a second third-rib endpoint; and
a third rib axis intersecting the first and second third-rib endpoints;
 the third rib length extends from the first third-rib endpoint to the second third-rib endpoint;
 the third rib width is substantially parallel to the rib surface and substantially orthogonal to the third rib length; and
 the third rib height is substantially orthogonal to the rib surface; and
with respect to a top view of the golf club head:
the first, second, and third rib axes intersect each other and are tangent to a locus defined by a conic section perimeter; and
one or more of the first rib width, the second rib width, and the third rib width vary respectively across the first rib length, the second rib length, and the third rib length;
the first rib axis is tangent to the conic section perimeter at a first tangency point located towards a heelside end of the conic section perimeter;
the second rib axis is tangent to the conic section perimeter at a second tangency point located towards a toeside end of the conic section perimeter; and
the third rib axis is tangent to the conic section perimeter at one of:
a third tangency point located between the first tangency point and a most rearward point of the conic section perimeter; or
a fourth tangency point located between the second tangency point and the most rearward point of the conic section perimeter.

US Pat. No. 10,427,000

EXERCISE AND REHABILITATION DEVICE

1. A device for exercising or rehabilitating a hand, arm, shoulder or related joints of a user, comprising:a flat base plate having an upper side and a lower side;
a first flexible joint comprising a horizontally disposed pad having an upper side and a lower side, and a cylindrical portion having an upper end and a lower end, which extends upwardly from said horizontally disposed pad;
said horizontally disposed pad being secured to said flat base plate;
an elongated lower tube having an open lower end and an open upper end;
said cylindrical portion of said first flexible joint extending upwardly into said open lower end of said elongated lower tube and being secured to said open lower end of said elongated lower tube;
an elongated upper tube having an open upper end and a lower end;
said elongated upper tube telescopically slidably extending downwardly into said open upper end of said elongated lower tube;
a locking collar at said open upper end of said elongated upper tube for selectively locking said elongated upper tube in various telescopic positions with respect to said elongated lower tube;
an open hand support having an upper side and a lower side;
a second flexible joint having an upper end and a cylindrical portion which extends downwardly from said upper end of said second flexible joint;
said upper end of said second flexible joint being secured to said lower side of said open hand support; and
said cylindrical portion of said second flexible joint extending downwardly into said open upper end of said elongated upper tube and being secured thereto.

US Pat. No. 10,426,964

WEARABLE CARDIAC DEFIBRILLATOR SYSTEM EMITTING CPR PROMPTS FOR BYSTANDER

West Affum Holdings Corp....

1. A wearable cardiac defibrillator (WCD) system, comprising:a support structure configured to be worn by a patient;
an energy storage module configured to store an electrical charge;
a discharge circuit configured to be coupled to the energy storage module and configured to discharge the stored electrical charge through the patient;
one or more motion detectors coupled to the support structure, at least one of the motion detectors being coupled to the support structure at such a point as to be near a back of the patient while the support structure is worn by the patient; and
a speaker system coupled to the support structure and configured to output a transmitted sound having substantially periodic contents designed to assist a bystander to perform CPR chest compressions on the patient while the support structure is worn by the patient, and
in which the performed CPR chest compressions are detected by the one or more motion detectors and
the transmitted sound further communicates feedback regarding the detected CPR chest compressions.

US Pat. No. 10,426,958

INTRANASAL STIMULATION FOR ENHANCED RELEASE OF OCULAR MUCINS AND OTHER TEAR PROTEINS

Oculeve, Inc., San Franc...

1. A method for increasing ocular mucin on an ocular surface of a subject, comprising:applying one or more active agents to the ocular surface prior to intranasally delivering an electrical stimulation to the subject, thereby increasing a density of goblet cells on the ocular surface, the one or more active agents comprising cyclosporine;
intranasally delivering the electrical stimulation to the subject after applying the one or more active agents to the ocular surface; and
stimulating release of the ocular mucin from the goblet cells,
wherein the increased density of goblet cells and the released ocular mucin from the goblet cells improves a condition of an eye of the subject.

US Pat. No. 10,426,953

INTERVENTIONAL MEDICAL SYSTEMS, TOOLS, AND METHODS OF USE

Medtronic, Inc., Minneap...

1. A delivery tool facilitating deployment of an implantable medical device, the device including an electronic controller, a hermetically sealed housing containing the controller, a fixation member, and an extension coupled to the controller, the extension extending from a proximal end of the housing, the extension including a sense electrode, and the tool comprising:a handle including a control member;
an elongate grasping mechanism including a tubular shaft and a pair of arms longitudinally movable within a lumen of the tubular shaft, each arm including a curved distal end protruding from a distal opening of the lumen of the shaft, at a distal end of the shaft, the curved distal ends being configured to spread apart from one another and to close together, via longitudinal movement of the arms within the lumen of the shaft, and the curved distal ends being configured to grip the extension of the device; and
an elongate deployment tube including a proximal end coupled to the control member of the handle, a distal-most portion, and a lumen extending from a proximal opening thereof at the proximal end of the deployment tube to a distal opening thereof that terminates the distal-most portion at a distal end thereof, the grasping mechanism extending within the lumen of the deployment tube such that an entirety of the deployment tube is longitudinally moveable with respect to the grasping mechanism by means of the control member of the handle,
wherein the lumen of the deployment tube, along a length of the distal-most portion, is sized to contain an entirety of the housing of the device and the fixation member together with the curved distal ends of the arms of the grasping mechanism gripping the extension of the device when the extension of the device extends proximally from the distal-most portion within the lumen of the deployment tube,
wherein a diameter of the lumen of the deployment tube along the length of the distal-most portion is greater than the diameter of the lumen of the deployment tube proximal of the distal-most portion, and
wherein the grasping mechanism is moveable outside the lumen of the deployment tube, distal to the distal opening thereof.

US Pat. No. 10,426,941

NASAL TUBE DEVICE AND METHOD

APPLIED MEDICAL TECHNOLOG...

1. A nasal tube system comprising: a nasal tube, the nasal tube comprising:a first opening at a proximal end;
a second opening at a distal end;
a delivery window between the proximal end and the distal end and in an outer surface of the nasal tube;
a main lumen extending an entire length of the nasal tube from the first opening to the second opening;
a delivery lumen extending from the first opening to the delivery window; and
a wall at least partially separating and defining the main lumen and the delivery lumen,
wherein the nasal tube is configured to be inserted into a first nostril of a patient with the proximal end and the first opening positioned outside of the patient, and the second opening and the delivery window open to pharyngeal space of the patient; and a flexible line that secures the nasal tube to the patient by extending through the delivery lumen and the delivery window of the nasal tube.

US Pat. No. 10,426,939

DISPOSABLE LIQUID APPLICATOR SACHET

DAKLAPACK EUROPE B.V., L...

1. A disposable liquid applicator sachet, comprising:a base sheet and a top sheet, each of the base sheet and the top sheet having a reservoir sheet portion and an applicator sheet portion, and said top sheet being sealed onto said base sheet such that the reservoir sheet portions of said base sheet and said top sheet define therebetween a reservoir for holding a liquid, and the applicator sheet portions of said base sheet and said top sheet define therebetween a conduit, which conduit extends from the reservoir up to an outlet opening provided in the applicator sheet portion of the top sheet; and
an applicator pad, which applicator pad is attached to the applicator sheet portion of the top sheet, such that the applicator pad covers the outlet opening,
wherein the disposable liquid applicator sachet is folded with an applicator portion thereof onto a reservoir portion thereof, and wherein a sharp fold is present between the reservoir portion of the disposable liquid applicator sachet and the applicator portion of the disposable liquid applicator sachet, which sharp fold blocks the conduit to such an extent that the liquid held in the reservoir is prevented from flowing into the conduit,
wherein the applicator portion of the disposable liquid applicator sachet is sealed onto the reservoir portion of the disposable liquid applicator sachet in sealing zones, which sealing zones are located on opposite sides of the conduit, and which sealing zones extend up to the fold,
wherein the applicator portion of the disposable liquid applicator sachet comprises a tear line on each side of the conduit, which tear lines are each located between the conduit and a sealing zone and which tear lines extend from an edge of the applicator portion up to the sharp fold, and
wherein the applicator portion of the disposable liquid applicator sachet comprises a grip tab for pulling the applicator portion of the disposable liquid applicator sachet away from the reservoir portion of the disposable liquid applicator sachet, which grip tab is provided between the two tear lines at a distance from the fold, such that by pulling the grip tab away from the reservoir portion of the disposable liquid applicator sachet, the applicator portion tears along the tear lines and a part of the applicator portion of the disposable liquid applicator sachet, the part comprising the conduit and the outlet opening, can be unfolded to allow the liquid held in the reservoir to flow into the conduit and out of the outlet opening into the applicator pad.

US Pat. No. 10,426,938

MEDICAL DRESSING INTERFACE DEVICES, SYSTEMS, AND METHODS

KCI Licensing, Inc., San...

29. A method for instilling fluid at a tissue site, comprising:positioning a distribution manifold adjacent a surface of the tissue site, the distribution manifold comprising a tissue-facing side facing the tissue site and an outward-facing side opposite the tissue-facing side;
positioning an adapter adjacent the distribution manifold, the adapter comprising:
a conduit housing including a recessed region defining an entry surface, the entry surface facing the outward-facing side of the distribution manifold,
a primary port on the entry surface,
at least one ancillary port on the entry surface, and
at least one port extension including a proximal end, a distal end, and a bore between the proximal end and the distal end, the distal end of the port extension in fluid communication with the ancillary port through the bore;
inserting the distal end of the port extension into the distribution manifold; and
delivering fluid to the surface of the tissue site through the ancillary port and the distal end of the port extension.

US Pat. No. 10,426,937

BI-PHASE FLUID SURGE SUPPRESSOR DEVICE

1. A siphon guard comprising:a housing having an inlet and an outlet opposite the inlet, the inlet and outlet being axially alignable with a shunt flow path;
a primary flow path disposed within the housing and in fluid communication with the inlet and the outlet, the primary flow path having a generally axial orientation;
a secondary flow path disposed around the primary flow path and within the housing and in fluid communication with the inlet and the outlet, the secondary flow path having a generally helical orientation and a higher resistance to fluid flow than the primary path; and
a valve disposed within the primary flow path, the valve having a valve seat and a first ball and a second ball, the first ball being movable between a valve closed position where the first ball is moved towards the outlet and in contact with the valve seat and a valve open position where the first ball is moved away from the outlet and spaced from the valve seat thereby permitting egress of fluids from the valve from the first ball and then to the outlet distal thereof,
the first ball is disposed between the second ball and the valve seat,
the second ball being movable between the valve closed position and the valve open position;
wherein the second ball being movable by a weight of the second ball between the valve closed position and the valve open position, and
wherein the primary flow path forms a “u” bend between the inlet and the valve.

US Pat. No. 10,426,936

BALLOON CATHETERS WITH INCREASED COLUMN STRENGTH

BOSTON SCIENTIFIC SCIMED,...

1. A medical device, comprising:an expandable member having a proximal waist and a distal waist;
an outer member having a proximal end, a distal end and a lumen extending therein, wherein the outer member is attached to the proximal waist of the expandable member;
an inner member having a proximal end and a distal end, the inner member disposed within the lumen of the outer member, wherein the inner member is attached to the distal waist of the expandable member; and
a movement limiting member connecting the inner member to the outer member,
wherein the movement limiting member is a coil having a proximal end and a distal end, wherein the distal end of the coil is directly attached to the inner member;
wherein the movement limiting member is configured to limit movement of the outer member relative to the inner member.

US Pat. No. 10,426,935

REINFORCED SYRINGE BODY

Merit Medical Systems, In...

1. A syringe body configured for use in connection with a high-pressure inflation device, the syringe body comprising:a first wall defining a fluid reservoir, the fluid reservoir configured to receive a plunger;
a second wall defining a distal end of the fluid reservoir, the second wall comprising:
at least one stiffening rib; and
an inlet/outlet port disposed in the second wall,
wherein a distal end of the first wall extends distally relative to the second wall along a circumference of the second wall forming an annular stiffening lip,
wherein the second wall defines an interior surface of the fluid reservoir extending between the first wall and the inlet/outlet port, and
wherein the at least one stiffening rib extends inward of the annular stiffening lip along an exterior surface of the second wall.

US Pat. No. 10,426,934

BALLOON CATHETER

ABBOTT CARDIOVASCULAR SYS...

1. A balloon catheter comprising:an outer shaft including a hypotube and a monolithic single-layer distal outer member of polymer material, the outer shaft having an inflation lumen defined therethrough, wherein the monolithic single-layer distal outer member is necked to a reduced diameter along an entire length thereof with the polymer material consisting essentially of polymer chains in a linear orientation, wherein a proximal end of the monolithic single-layer distal outer member is coupled to the hypotube, and wherein a distal section of the hypotube comprises a skive defined by a first angled cut, an axial cut, and a second angled cut;
a balloon in fluid communication with the inflation lumen, the balloon having a proximal balloon shaft coupled to a distal end of the monolithic single-layer distal outer member; and
a monolithic inner tubular member having a guidewire lumen defined therethrough, the monolithic inner tubular member extending distally from a proximal port in the monolithic single-layer distal outer member through the balloon to form a tip.

US Pat. No. 10,426,933

CATHETER HAVING MONOLITHIC MULTILAYER DISTAL OUTER MEMBER

ABBOTT CARDIOVASCULAR SYS...

1. A balloon catheter, comprising:an outer shaft including a hypotube and a monolithic multilayer distal outer member of polymer material, the outer shaft having an inflation lumen defined therethrough, the monolithic multilayer distal outer member having a proximal end portion and a distal end portion, the monolithic multilayer distal outer member having an inner layer comprising a first polymer having a tensile strength greater than 8,000 psi and an outer layer comprising a second polymer having a flexural modulus of less than 130,000 psi at room temperature, wherein a proximal end of the monolithic multilayer distal outer member is coupled to the hypotube, wherein the monolithic multilayer distal outer member is necked to a reduced diameter along an entire length thereof with the polymer material consisting essentially of polymer chains in a linear orientation;
a balloon in fluid communication with the inflation lumen, the balloon having a proximal balloon shaft coupled to a distal end of the monolithic multilayer distal outer member; and
an inner tubular member having a guidewire lumen defined therethrough, the inner tubular member extending distally from a proximal port in the proximal end portion of the monolithic multilayer distal outer member through at least a portion of the balloon.

US Pat. No. 10,426,932

METHOD AND APPARATUS FOR INTRODUCING AN INTRAVENOUS CATHETER

1. An I.V. catheter insertion assembly comprising:a) a tubular member that is transparent and has a body, a first end, and a second end, wherein the first end is located at a proximal end of the body and is mammillated, and wherein the second end is located at a distal end of the body;
b) a plunger assembly slidable within the body of said tubular member, the plunger assembly having a chamber that is continuous and transparent, and the plunger assembly having a finger paddle and a control knob at a distal end of the plunger assembly;
c) said chamber of the plunger assembly in fluid communication with said control knob at the distal end of the plunger assembly;
d) a needle base and a sealing member that is air-tight, wherein the sealing member is at a proximal end of the chamber, the sealing member in slidable vacuum sealing contact along an interior surface of the body of the tubular member;
e) a needle that is elongated, beveled, and tubular, the needle embedded within said needle base and extending therefrom with said needle in fluid communication with said chamber, and the needle having a needle tip;
f) an I.V. catheter comprising a cannula, wherein the cannula is flexible, transparent, and is an I.V. cannula, the cannula having a cannula tip and a hub that is transparent, the hub attached to said first end of the tubular member with said needle operable to pass longitudinally through said cannula;
g) the plunger assembly operable to move within the tubular member between a neutral position and one or more retracted positions, wherein in the neutral position the sealing member and needle base are at or near a junction of the first end of the tubular member and the body, and wherein the needle passes longitudinally through said cannula and with the needle tip extending exterior to said cannula tip, and wherein in the one or more retracted positions the needle tip is retracted to an interior of the cannula;
h) a fluid passage formed in a space between said needle and said cannula when the needle passes longitudinally through said cannula; and
i) wherein when moving to the one or more retracted positions, retraction of the plunger assembly causes a vacuum in the fluid passage and suction on the cannula tip, said suction visibly drawing blood into the fluid passage and along a longitudinal length of the fluid passage enabling a user to verify that the cannula has entered a blood vessel.

US Pat. No. 10,426,931

CATHETER PLACEMENT DEVICE AND METHOD

C. R. Bard, Inc., Murray...

1. An insertion tool for inserting a catheter into a body of a patient, comprising:a housing;
a needle having a proximal portion in the housing and a distal portion extending from a distal end of the housing;
a catheter advancement assembly, comprising:
the catheter coaxially disposed over the needle, the catheter having a proximal end in the housing and a distal end extending from the distal end of the housing in a catheter first position; and
a handle coupled to the proximal end of the catheter, the handle extending laterally from the housing in the catheter first position, the handle slidable with respect to the housing to transition the catheter distally from the catheter first position to a catheter second position; and
a guidewire advancement assembly, comprising:
a guidewire disposed at least partially in a lumen of the needle; and
a slide member coupled to the guidewire, the slide member slidable with respect to the housing to transition the guidewire relative to the needle.

US Pat. No. 10,426,930

SYSTEMS AND METHODS FOR NEEDLE AND CATHETER ADVANCEMENT

Vascular Pathways, Inc., ...

1. A method, comprising:obtaining a medical device, comprising:
a catheter; and
a needle including a dilating element permanently attached to an exterior of the needle at a distal portion of the needle proximate a tissue-penetrating distal end thereof, the dilating element having an outer diameter equal to or greater than a diameter of an opening at a distal end of the catheter, the needle situated in a first medical device position such that at least a portion of the dilating element is in the opening and the tissue-penetrating distal end is distal of the opening;
penetrating a vein with the tissue-penetrating distal end of the needle;
moving the distal end of the catheter into the vein;
advancing the catheter into the vein over the needle; and
removing the needle from the catheter.

US Pat. No. 10,426,929

INTEGRATED PERIPHERAL INTRA-VENOUS CATHETER WITH IMPROVED EXTENSION TUBE PORT PROBE ACCESS

Becton, Dickinson and Com...

1. A vascular access device, comprising:a catheter for insertion into a biological site;
a catheter adapter having a catheter hub and a side port coupled to the catheter hub, the catheter hub having a first end operably coupled to the catheter, a second end opposite the first end, and an internal wall defining an internal fluid passageway therebetween, the side port having another internal wall defining a lumen in fluid communication with the internal fluid passageway, wherein the other internal wall of the side port comprises a distal surface and a proximal surface opposite the distal surface, wherein the side port further comprises a protrusion extending outwardly from the proximal surface; and
a septum disposed within the internal fluid passageway;
wherein the protrusion is configured to deflect a probe entering the catheter hub from the side port towards the first end of the catheter hub such that the probe contacts the internal wall at a contact angle between 90 degrees and 180 degrees.

US Pat. No. 10,426,928

STABILIZING DEVICE HAVING A SNAP CLAMP

Venetec International, In...

1. A retainer for securing a medical article to a patient, comprising:a base;
a first arcuate wall and a second arcuate wall that together define a channel designed to receive the medical article, the retainer having:
an open configuration wherein a first end of the first arcuate wall is spaced away from a first end of the second arcuate wall; and
a closed configuration wherein the first end of the first arcuate wall is adjacent the first end of the second arcuate wall,
wherein a second end of the first arcuate wall opposite the first end of the first arcuate wall is spaced away from the base in the open configuration and contacts the base in the closed configuration, the second end of the first arcuate wall hingedly connected to a second end of the second arcuate wall, the second end of the first arcuate wall moving parallel to a transverse axis when transitioning between the open configuration and the closed configuration;
a first support fixed to the base;
a second support fixed to the base;
a first flexible coupling connecting the first support to the first arcuate wall; and
a second flexible coupling connecting the second support to the second arcuate wall,
wherein the first flexible coupling and the second flexible coupling transition from a relaxed condition in the open configuration to a stretched condition in the closed configuration.

US Pat. No. 10,426,927

TELESCOPING CATHETERS AND METHODS FOR USE

CLPH, LLC, Palo Alto, CA...

1. An apparatus for performing a medical procedure within a patient's body, comprising:a first elongate member comprising a first proximal portion, a first distal portion sized for introduction into a patient's body and including a first distal end, and a lumen extending between the first proximal portion and the first distal end;
a second elongate member comprising a second proximal portion, a second distal portion slidably received within the lumen and including a second distal end, the second elongate member being movable relative to the first elongate member between a retracted position and a distal position where the second distal end extends distally from the first distal end; and
cooperating magnetic elements on the first and second distal ends at locations to secure the second elongate member at the retracted position using a magnetic attraction between the magnetic elements, the magnetic attraction being such that a predetermined force disengages the magnetic elements to allow the second elongate member to be directed from the retracted position towards the extended position,
wherein the first distal end terminates at a first distal tip, and wherein the magnetic elements comprise a first magnetic element on the first distal tip at least partially surrounding an outlet of the lumen and a second magnetic element on the second distal end such that when the second distal end is directed to the retracted position, the second magnetic element abuts the first distal tip, and
wherein the second elongate member terminates at a second distal tip, and wherein the second magnetic element comprises an enlarged member on the second distal tip having a cross-section larger than the outlet of the lumen such that the second magnetic element contacts the first distal tip surrounding the outlet.

US Pat. No. 10,426,925

MEDICAL DEVICES FOR THE IDENTIFICATION AND TREATMENT OF BODILY PASSAGES

Cook Medical Technologies...

1. A method of treating tissue in a bodily passage wall defining a bodily passage and an ostium, the method comprising the steps of: introducing a first medical device having a first proximal end and a first distal end into said bodily passage such that the first distal end is disposed within said bodily passage, the first medical device comprising: an elongate member having an elongate member proximal end, an elongate member distal end, an elongate member first portion, an elongate member second portion, and defining an elongate member first lumen and an elongate member second lumen, the elongate member first portion extending from the elongate member proximal end towards the elongate member distal end to a location between the elongate member proximal end and the elongate member distal end, the elongate member second portion extending from the elongate member distal end towards the elongate member proximal end to the location between the elongate member proximal end and the elongate member distal end, the elongate member first portion attached to the elongate member second portion at the location between the elongate member proximal end and the elongate member distal end, the elongate member movable between a substantially straight configuration and a curved configuration a handle disposed on the elongate member and having a handle proximal end, a handle distal end, and an actuator moveable between an actuator first position and an actuator second position, in the actuator first position the elongate member is in the substantially straight configuration, in the actuator second position the elongate member is in the curved configuration, the handle disposed between the elongate member proximal end and the elongate member distal end such that a portion of the elongate member is positioned between the elongate member proximal end and the handle proximal end; and a wire member partially disposed within the elongate member first lumen and having a wire member first end attached to the actuator and a wire member second end attached to the elongate member; advancing the first medical device into said bodily passage; advancing the actuator from the actuator first position to the actuator second position such that the elongate member moves from the substantially straight configuration to the curved configuration; advancing the first distal end through said ostium defined by said bodily passage wall and into a sinus cavity; introducing a second medical device having a second proximal end and a second distal end into the elongate member second lumen such that the second distal end is disposed within the elongate member second lumen; advancing the second medical device through the elongate member second lumen such that the second distal end is disposed distal to the first distal end and in the sinus cavity; providing treatment using the second medical device; stopping the step of providing treatment using the second medical device; withdrawing the second medical device from the elongate member second lumen such that the second distal end is disposed proximal to the first proximal end; advancing the actuator from the actuator second position to the actuator first position such that the elongate member moves from the curved configuration to the substantially straight configuration; and withdrawing the first medical device from said bodily passage such that the first distal end is disposed outside of said bodily passage; wherein the elongate member first portion is rigid and the elongate member second portion is flexible relative to the elongate member first portion; wherein the elongate member first lumen extends from a first lumen first opening disposed between the elongate member proximal end and the elongate member distal end; and wherein the wire member extends through the first lumen first opening.

US Pat. No. 10,426,924

PLACEMENT AID FOR PLACING A CATHETER FOR DIABETICS

1. A placement aid for placing a catheter and a sensor wire into a body comprising:a placement device;
a replacement device with a main body, a placement needle, a catheter and a sensor wire;
wherein the replacement device is arranged in the placement device in an interchangeable and replaceable manner,
wherein the placement needle is coupled to the main body,
wherein the placement needle and the catheter are arranged with regard to each other in such a way that the placement needle is arranged within the catheter, and that a tip of the placement needle protrudes from a proximal end of the catheter along a puncturing direction so that upon placement of the catheter along the puncturing direction, the tip of the placement needle penetrates a skin in order to produce a skin opening through which the catheter can be guided up to a subcutaneous end position, and
wherein the sensor wire is coupled to the placement needle in such a way that upon placement of the catheter along the puncturing direction, the sensor wire is arranged in the placement needle and that, upon reaching the subcutaneous end position of the catheter, the placement needle can be removed from the catheter against the puncturing direction and the sensor wire remains in the catheter; and
a holding-down rod which is arranged in the placement needle in a displaceable manner,
wherein the holding-down rod is designed to frictionally press the sensor wire against the placement needle, and
wherein the holding-down rod is further arranged at the main body in a movable manner along the puncturing direction such that, upon placement of the catheter along the puncturing direction, the placement needle, the sensor wire and the holding-down rod can jointly be advanced up to the subcutaneous end position of the catheter and such that, upon reaching the subcutaneous end position of the catheter, the holding-down rod can be withdrawn from the catheter against the puncturing direction.

US Pat. No. 10,426,923

CATHETER TIP ASSEMBLED WITH A SPRING

Medinol Ltd., Tel Aviv (...

20. A flexible catheter, comprising:a longitudinal catheter body extending from a proximal end to a distal end; and
a flexible catheter tip located at said distal end of said longitudinal catheter body, said flexible catheter tip including a spring element having a proximal end and a distal end that is a distal-most end of the flexible catheter, said spring element defining an inner lumen having n inner luminal diameter and an outer diameter;
wherein said spring element is a wire coil having pitch space between two or more coils in a first region and tightly packed coils in a second region, said second region being distal of said first region,
wherein said wire coil having a decreasing cross-sectional diameter from the proximal end of the spring element to the distal end of the spring element, and
wherein said inner luminal diameter tapers at a lesser rate than the outer diameter of the spring element.

US Pat. No. 10,426,922

MEDICAL APPARATUS AND METHOD OF MAKING THE SAME

1. A catheter assembly comprising:a catheter having a proximal end and a distal end;
an expandable device releasably attached to the catheter near the distal end, wherein the expandable device is maintained in a compressed state for endoluminal delivery;
a tip fixedly secured to the distal end of and generally coaxial with the catheter; and
a bridge member generally coaxial with the catheter and disposed in a gap between the expandable device and the tip, the bridge member being positioned distally to the expandable device and axially compressed between the tip and the expandable device such that the bridge member fills the gap between the expandable device and the tip with the expandable device maintained in the compressed state, such that the bridge member is configured to fill the gap between the expandable device and the tip during endolum inal delivery of the catheter assembly.

US Pat. No. 10,426,920

INTEGRATED CATHETER SYSTEM

BOSTON SCIENTIFIC SCIMED,...

1. A guide catheter, comprising:an inner layer defining a lumen extending therethrough;
a reinforcing braid disposed about the inner layer, the reinforcing braid comprising a plurality of wires interwoven with each other in an alternating over and under fashion;
a plurality of steering wires interwoven through the reinforcing braid; and
an outer layer disposed about the reinforcing braid;
wherein at least a portion of the reinforcing braid is embedded within the outer layer.

US Pat. No. 10,426,919

SYSTEMS AND METHODS FOR INDUCING NEGATIVE PRESSURE IN A PORTION OF A URINARY TRACT OF A PATIENT

Strataca Systems Limited,...

1. A system for inducing negative pressure in a portion of a urinary tract of a patient, the system comprising:(a) a ureteral catheter comprising a distal portion configured for insertion within the patient's kidney and a proximal portion;
(b) a bladder catheter comprising a distal portion configured for insertion within the patient's bladder and a proximal portion for application of negative pressure, the proximal portion configured to extend outside of the patient's body; and
(c) a pump external to the patient's body for application of negative pressure through both the bladder catheter and the ureteral catheter, which in turn causes fluid from the kidney to be drawn into the ureteral catheter, through both the ureteral catheter and the bladder catheter, and then outside of the patient's body.

US Pat. No. 10,426,918

FLUSHABLE CATHETERS

Hollister Incorporated, ...

1. A catheter assembly comprising:a catheter shaft having proximal and distal end portions; and
a funnel assembly fixedly secured to the distal end portion of the catheter shaft, wherein
a drainage portion is defined through the funnel assembly and the funnel assembly includes
a groove along at least a portion of an outer perimeter of the funnel assembly and/or
a shaft channel defined through the funnel assembly, with the groove and/or the shaft channel being configured to receive at least a portion of the catheter shaft for securing said at least a portion of the catheter shaft to the funnel assembly for disposal,
the drainage portion is positioned between a pair of lateral portions,
each lateral portion includes a front face and a rear face, and
the groove is defined between the front and rear faces.

US Pat. No. 10,426,917

SYSTEM AND METHOD FOR MANUFACTURING VARIABLE STIFFNESS CATHETERS

Stryker Corporation, Kal...

1. A system for manufacturing a catheter, comprising:a first material feeder coupled to a first material source;
a second material feeder coupled to a second material source;
a thermally controlled mixer coupled to the first and second material feeders, wherein the first material feeder is configured to feed a first material from the first material source into the mixer at a first material feed rate, and the second material feeder is configured to feed a second material from the second material source into the mixer at a second material feed rate, such that the first and second materials are combined in the mixer to form a compound material that varies in content as a function of the respective first and second materials, and of the first and second material feed rates;
a catheter formation mandrel having a longitudinal axis, the mandrel being controllably rotatable about the longitudinal axis at a mandrel rotation rate;
an extruder operatively coupled to the mixer and having an output nozzle configured to apply compound material from the mixer onto the catheter formation mandrel; and
a control system comprising one or more processors that control one or more of the first material feed rate, second material feed rate, and mandrel rotation rate, respectively, so as to enable formation of a catheter having a variable stiffness profile along a length of the catheter,
wherein the extruder is configured to apply an extrusion of compound material from the mixer onto the catheter formation mandrel such that the extrusion winds around the mandrel forming adjacent loops of compound material on the catheter formation mandrel.

US Pat. No. 10,426,916

METHOD OF USING AUTONOMIC NERVE FLUCTUATIONS AND SYSTEM USING THE SAME

PANASONIC INTELLECTUAL PR...

1. A method comprising:obtaining, by a processor and from a camera, information about a period of a fluctuation cycle in an autonomic nerve of a user; and
causing, by the processor, to repeat, in a same period as the period of the fluctuation cycle in the autonomic nerve, a process that includes inducing a point of gaze of the user to move along an optical axis of the user in a direction away from the user, and inducing the point of gaze of the user to move along the optical axis of the user in a direction to approach the user, according to the obtained information;
wherein
the period of the fluctuation cycle in the autonomic nerve is a period of a fluctuation cycle in a diameter of a pupil of the user.

US Pat. No. 10,426,915

SURGICAL INSTRUMENT HAVING AN INTEGRATED LOCAL ANESTHETIC DELIVERY SYSTEM

1. A surgical instrument configured for locally delivering anesthetic while implanting a mechanism configured for treating female urinary incontinence, the surgical instrument comprising:a handle portion defining a reservoir;
a longitudinally curved sling- and anesthetic-delivery incising tube in fluid communication with the reservoir, and configured to:
form a path in the abdomen of the patient;
move a sling through pelvic fascia of the patient; and
position the sling between the patient's urethra and vaginal wall;
an anesthetic delivery actuator that is connected to a biasing member, in ratcheting engagement with a plunger disposed within the reservoir and configured to move the anesthetic delivery actuator; an actuator guard disposed on the handle portion and configured to prevent inadvertent actuation of the anesthetic delivery actuator;
the biasing member;
the plunger; a local anesthetic inlet tube that is partially housed within the handle portion, terminates at an inlet port sealed by a valve cap that provides pressure release without fluid release, and is in fluid communication with the reservoir; and
the valve cap;
wherein:
the surgical instrument is configured to locally deliver the anesthetic while assisting the surgeon with forming the path through, moving the sling within, and implanting the sling in, the patient's abdomen.

US Pat. No. 10,426,914

SYSTEM AND METHOD FOR ADJUSTING HUMIDIFICATION DURING PRESSURE SUPPORT THERAPY

KONINKLIIKE PHILIPS N.V.,...

1. A pressure support system configured to adjust humidity and/or temperature of a pressurized flow of breathable gas delivered to a subject, the pressure support system comprising:a pressure generator configured to generate a pressurized flow of breathable gas for delivery to an airway of the subject;
a humidifier configured to humidify the pressurized flow of breathable gas;
one or more sensors configured to generate output signals conveying information related to one or more parameters of the pressurized flow of breathable gas;
a user interface configured to receive entry and/or selection of feedback information from the subject indicating a comfort level with the pressurized flow of breathable gas; and
one or more physical computer processors configured by computer readable instructions to:
control the pressure generator and the humidifier to deliver the pressurized flow of breathable gas to the subject according to a predetermined therapy regime based on the output signals;
receive feedback information entered and/or selected through the user interface;
make an automatic adjustment to the pressurized flow of breathable gas to enhance the comfort level of the subject, the automatic adjustment based on the received feedback information and the output signals, the automatic adjustment including adjustment of one or more of the pressure generator or the humidifier;
receive additional feedback information entered and/or selected through the user interface subsequent to the automatic adjustment; and
prompt the subject to manually adjust one or more of the pressure generator, the humidifier, or an ambient environment based on the additional feedback information.

US Pat. No. 10,426,913

APPARATUS AND METHOD FOR MONITORING NITRIC OXIDE DELIVERY

Mallinckrodt Hospital Pro...

1. An apparatus to deliver therapeutic gas to a patient, the apparatus comprising:a first inlet to be placed in fluid communication with a therapeutic gas supply providing a continuous flow of nitric oxide at a therapeutic gas supply concentration;
a second inlet to be placed in fluid communication with a breathing gas delivery system providing a continuous flow of a breathing gas to the patient;
a therapeutic gas injector module to be placed in fluid communication with the first inlet and the second inlet to provide a combined continuous flow of breathing gas and therapeutic gas;
an outlet in fluid communication with the therapeutic gas injector module to supply the combined continuous flow of breathing gas and therapeutic gas to the patient;
a control circuit including a first flow sensor to measure the continuous flow of breathing gas from the breathing gas delivery system and a second flow sensor to measure the continuous flow of therapeutic gas, wherein the control circuit determines a calculated dose of nitric oxide based on the measured flow of breathing gas and either the measured flow of therapeutic gas or a known continuous flow of therapeutic gas; and
a display in communication with the control circuit that provides a visual and/or numeric indication of the calculated dose of nitric oxide, wherein the visual and/or numeric indication of the calculated dose of nitric oxide is provided as a percentage of a desired delivery concentration to be delivered to the patient, wherein the desired delivery concentration is set by a user; and
wherein the visual and/or numeric indication of the calculated dose of nitric oxide as the percentage of the desired delivery concentration is indicated on the display as being in one of a target delivery region, an under-delivery of nitric oxide region, and an over-delivery of nitric oxide region.

US Pat. No. 10,426,912

ZONE HEATING FOR RESPIRATORY CIRCUITS

17. A medical tube comprising:a first segment comprising one or more heater wires;
a second segment comprising one or more heater wires;
a connection circuit adapted to connect the first and second segments, the connection circuit comprising a diode; and
a controller,
wherein each of the first and second segments further comprises a spirally wound elongate hollow body and a spirally wound elongate bead member, the spirally wound elongate hollow body forming at least in part an elongate tube comprising a longitudinal axis and a lumen extending along the longitudinal axis, the elongate bead member forming at least a portion of the lumen and providing support for the elongate hollow body, and
wherein the controller is adapted to selectively switch between a first mode in which the controller provides power to the first segment, and a second mode in which the controller provides power to the first and second segments,
wherein a heater circuit comprising the one or more heater wires of the first and second segments is independent of another heater circuit that heats another tube.

US Pat. No. 10,426,911

RESPIRATORY THERAPY CONDENSATION ADAPTOR

VAPOTHERM, INC., Exeter,...

1. An adaptor for coupling a tracheostomy tube to a source of humidified breathing gas, the adaptor comprising:a housing having an interior surface, an exterior surface, and a breathing gas port for receiving a flow of humidified breathing gas from the source, the breathing gas port extending from the exterior surface to the interior surface;
a tracheostomy tube connection device positioned within the housing, the tracheostomy tube connection device including an input port for receiving the flow of humidified breathing gas from the breathing gas port and an output port for coupling with the tracheostomy tube, the tracheostomy tube connection device having an internal surface defining a breathing gas passage and an external surface spaced from the interior surface of the housing to create a condensation passage wherein the condensation passage comprises a bottom end, and wherein the condensation passage is configured such that condensation flows towards the bottom end and exits the adaptor;
a baffle positioned between the breathing gas port and the input port to cause controlled condensation from the flow of humidified breathing gas by disrupting the flow of humidified breathing gas; and
at least one projection, positioned within the housing, to space the tracheostomy tube connection device from the interior surface of the housing.

US Pat. No. 10,426,910

CUSHION FOR MASK SYSTEM

ResMed Pty Ltd, Bella Vi...

1. A patient interface for providing a supply of pressurized air to a patient to treat Sleep Disordered Breathing (SDB) with Continuous Positive Airway Pressure (CPAP), the patient interface comprising:a rigid frame;
a soft cushion attached to the rigid frame, the soft cushion further comprising:
a nasal portion configured to seal at the patient's nose, the nasal portion further comprising at least one opening configured to direct the supply of pressurized air to the patient's nasal passages; and
a mouth portion configured to seal around the patient's mouth, the perimeter of the mouth portion further comprising a side wall, the mouth portion further comprising a membrane extending from the side wall and configured to seal with the patient's face, and the membrane forming an aperture configured to receive the patient's mouth and direct the supply of pressurized air to the patient's mouth;
an elbow assembly configured to connect the patient interface to an air delivery conduit; and
a headgear assembly configured to hold the rigid frame and the soft cushion in position on the patient's face,
wherein a flexible section of the perimeter of the mouth portion is relatively more flexible than the remainder of the mouth portion, and
wherein the side wall at the flexible section has a reduced thickness relative to the side wall around the remainder of the perimeter of the mouth portion.

US Pat. No. 10,426,909

NASAL RESPIRATORY ASSEMBLY AND METHODS OF USE

1. A nasal respiratory assembly for delivering a therapeutic treatment to a patient comprising:a) a mask having a top surface and a base, wherein said mask is configured with an exhaust port having a one-way valve positioned on said top surface;
b) a first rotatable intake port and a second rotatable intake port positioned on either side of said top surface, wherein said first and said second rotatable intake ports further comprises a directing means that directs pressurized gas from entering said patient's nasal cavities directly, and wherein said directing means is one or more louvered vents;
c) a hose having a first end and a second end adapted to be received by said first and second intake ports, and at least a third end; and
d) a rotatable medication delivery port provided on said hose and positioned proximal to at least one of said intake ports; and
wherein said therapeutic treatment is not delivered directly into the patient's nasal cavities.

US Pat. No. 10,426,907

METHOD AND SYSTEM FOR CONTROLLING A DRUG DOSING DEVICE

1. A method for controlling a drug dosing device for administering a drug to a patient, the method comprising:determining a quantity of the drug administered to the patient from the drug dosing device via a drug quantity determination device;
measuring a concentration of the drug in the gas exhaled by the patient as a first patient value via a concentration determining device;
providing a control system configured for:
carrying out a simulation calculation, in which a second patient value is calculated from the administered quantity of the drug, taking into account a parameter;
calculating a simulated first patient value in the simulation calculation, taking into account the parameter;
comparing the simulated first patient value to the measured first patient value;
adapting the parameter on the basis of the comparison; and
generating a control signal based on the second patient value, wherein the drug dosing device adapts the quantity of the drug administered to the patient based on the control signal, wherein the simulation calculation comprises a compartment model carried out based on:
blood circulation forming a first compartment;
a second compartment being taken into account, for which a concentration of the drug is calculated;
a third compartment being taken into account, for which a concentration of the drug is calculated;
the drug passing from the first compartment into the second compartment at a first rate;
the drug passing from the second compartment into the first compartment at a second rate;
the drug passing from the first compartment into the third compartment at a third rate;
the drug passing from the third compartment into the first compartment at a fourth rate;
the concentration of the drug in the breathing gas forming the first patient value being calculated such that a passage of the drug from the first compartment into the breathing gas takes place at a breathing gas rate; and
the drug being broken down from the first compartment at an elimination rate, which is the parameter, wherein the simulation calculation is carried out such that a passage of the drug from the lung into the breathing gas is calculated by a time lag element of the first order, so that an equation:
?1+k10·c1=K·k10·cp applies to the concentration (c1) of the drug in the breathing gas and a change to the concentration over time (?1), wherein cp is the concentration of the drug in the blood circulation and K and k10 are constants.

US Pat. No. 10,426,906

VENTILATOR MONITORING AND CONTROL

Mayo Foundation for Medic...

25. A computer-implemented patient information provisioning system, comprising:one or more mechanical ventilators for treating patients in a healthcare facility;
an interface operating on a computer processor system programmed to identify, as key words, terms likely to occur in electronic medical records that are determined to indicate presence of acute lung injury or acute respiratory distress syndrome, and obtain (a) data about operating parameters of the one or more mechanical ventilators, including information about the location(s) of the one or more mechanical ventilators, (b) information for electronically contacting particular caregivers who correspond to patients served by the one or more mechanical ventilators and are identified for contact based on a determination of what caregiver is currently assigned responsibility for a location in the healthcare facility that currently needs action by a caregiver, and (c) data from a central electronic medical records system operated by the healthcare facility, wherein the patient information provisioning system is programmed to automatically query written textual descriptions by caregivers in electronic medical records of the electronic medical record system to determine whether trigger terms in the records indicate that one or more particular patients under care have acute lung injury or acute respiratory distress syndrome;
an electronic patient evaluator to use the data about the current operating parameters of the one or more mechanical ventilators and the data from the central electronic medical records system to
(1) adjust an operational value for a first mechanical ventilator, of the one or more mechanical ventilators, from a normal value that is used for patients who do not have acute lung injury or respiratory distress syndrome, based on determining that a dangerous condition exists for a first patient as a combination of
(a) the first patient's electronic medical record having one or more key words that are indicative of acute lung injury or acute respiratory distress syndrome, and
(b) the first mechanical ventilator having a current value inconsistent with treatment of someone with acute lung injury or acute respiratory distress syndrome;
(2) determine that a potentially dangerous condition exists for the first patient based on a measured value for the first mechanical ventilator being excessive compared to the adjusted operational value; and
(3) identify that the first patient is receiving an inappropriate low tidal volume from the first mechanical ventilator by determining that a measured value for the first mechanical ventilator is excessive compared to the adjusted operational value; and
an alert module to provide, for transmission to one or more caregivers who are remote from the first mechanical ventilator, a notification of the identified dangerous condition.

US Pat. No. 10,426,905

METHODS AND SYSTEMS FOR IMPROVING AIRWAY PATENCY

SOMNICS, INC., Zhubei, H...

17. Apparatus for improving airway patency of a patient having an oral cavity, a hard palate, a soft palate, a tongue, lips, and an airway, the apparatus comprising: an oral device positionable in the oral cavity, the oral device comprising one or more ports through which negative pressure is applied to provide a continuous pathway for pressure delivery from the lips to the soft palate when the oral device is placed in the oral cavity, wherein the oral device is configured to apply negative pressure to generate a seal between the soft palate and a posterior region of the tongue to isolate the airway from the oral cavity, and wherein the oral device comprises a tongue constraint having a superior surface and an inferior surface, the surfaces being configured to maintain a clear region between a medial region of the tongue and the hard palate.

US Pat. No. 10,426,904

VOLUME REFLECTOR STATUS INDICATOR FOR ANESTHESIA SYSTEM

Maquet Critical Care AB, ...

1. An anesthesia system having a volume reflector, a breathing circuit, a processing unit, and a display operatively connected to said processing unit, wherein said processing unit is configured to provide a status indicator on said display for gas in said volume reflector, said status indicator including a real-time graphical representationof a driving gas of said volume reflector and a patient gas in said volume reflector; and
a flow of gas and a direction of said flow in said volume reflector;
wherein said status indicator comprises a graphical representation of adjacent gas pillars representing said driving gas and said patient gas in operation in said volume reflector, and said graphical representation further includes a representation of a present extent of said driving gas pillar and said patient gas pillar in said volume reflector during both an inhalation and an exhalation of a breathing cycle.

US Pat. No. 10,426,903

AUTOMATIC TRIGGER MODULE AND ELECTRONIC CIGARETTE THEREOF

JOYETECH EUROPE HOLDING G...

4. An electronic cigarette, comprising:an automatic trigger module, comprising:
a sensor, having a first end and a second end which are opposite to each other;
a circuit board, having a first vent hole communicating with the first end of the sensor and a first connection;
a sealing seat, having a second vent hole communicating with the second end; and
a control board, having a second connection,
wherein the first end is located on the circuit board, and the second end is located in the second vent hole, and
wherein the automatic trigger module is detachably connected to the control board, and when the automatic trigger module is connected to the control board, the first connection and the second connection contact with each other to realize a transmission of signal.

US Pat. No. 10,426,902

SYSTEMS FOR LAPAROSCOPIC SURGERY

1. A surgical humidification apparatus comprising:a heater base configured to contact a humidification chamber in use, the humidification chamber adapted to hold a volume of water and having an inlet and an outlet, the inlet in fluid communication with a gases source to receive gases from the gases source in use, the heater base configured to heat the water in the humidification chamber to create vapor to humidify gases passing through the humidification chamber from the inlet to the outlet in use; and
a controller configured to determine a low water or a no water condition of the humidification chamber based at least in part on an increase in power supplied to the heater base.

US Pat. No. 10,426,901

SYRINGE CAP HAVING REUSE PREVENTION STRUCTURE

1. A syringe cap having a reuse prevention structure, the syringe cap comprising:a fixed body (20) with a spiral protrusion (22) on an inner circumferential surface thereof, into which a dispensing tip (11) of a syringe barrel (10) is fitted, and whose bottom is coupled to the syringe barrel (10) by a fusion welding portion (21);
a separable body (30) with a spiral groove (31) on a lower part of an outer circumferential surface thereof, the spiral groove (31) being spirally engaged with the spiral protrusion (22) provided on the inner circumferential surface of the fixed body (20);
a rubber packing (40) fitted in the separable body (30) to seal and block the dispensing tip (11) of the syringe barrel (10) coupled to the fixed body (20); and
a reuse prevention cover (50) fitted over the fixed body (20) and the separable body (30) to cover the fixed body (20) and the separable body (30),
wherein the reuse prevention cover (50) includes:
an upper body (51) fitted over the separable body (30) to cover an outer surface of the separable body (30);
a lower body (52) fitted over the fixed body (20) to cover an outer surface of the fixed body (20), and positioned below a lower end of the upper body (51) such that a top of the lower body (52) is spaced apart from a bottom of the upper body (51); and
a connection breakable portion (53) which integrally connects the upper body (51) and the lower body (52) by connecting the bottom of the upper body (51) to the top of the lower body (52), and is broken by rotating the upper body (51) relative to the lower body (52) in a direction to separate the bottom of the upper body (51) from the top of the lower body (52), such that the separable body (30) covered with the upper body (51) is separated from the fixed body (20) to open the fixed body (20), and
wherein the spiral protrusion (22) of the fixed body (20) includes a tapered first pushing slope (23), and the spiral groove (31) of the separable body (30) includes a second pushing slope (32) corresponding to the first pushing slope (23) such that when rotating the upper body (51) of the reuse prevention cover (50) in one direction relative to the lower body (52) in a state of pushing the upper body (51) toward the lower body (52), the upper body (51) is pushed up by the lower body (52), thereby being easily broken due to breaking of the connection breakable portion (53) connecting the upper body (51) and the lower body (52) to each other.

US Pat. No. 10,426,900

AUTOMATIC INJECTION DEVICE

TERUMO KABUSHIKI KAISHA, ...

1. A method for measuring an amount of pain comprising:positioning a needle adjacent a non-human animal which is under anesthesia;
automatically inserting the needle at a controlled puncture speed into skin of the non-human animal by an automatic needle puncture device; and
measuring a muscle action potential of a muscle portion of the non-human animal produced by the insertion of the needle, the muscle action potential being measured from insertion start, at which the insertion of the needle into the skin is started, to insertion stop, at which the insertion of the needle into the skin is stopped,
whereby the measured muscle action potential indicates a measurement of the amount of pain.

US Pat. No. 10,426,899

MEDICAL DEVICE ASSEMBLY

Becton, Dickinson and Com...

1. A medical device assembly comprising:a fluid storage container having a visual indicator including three separate colored strips comprising a first colored stripe disposed closest to an opening of the fluid storage container, a second colored stripe disposed proximally adjacent to the first colored stripe, and a third colored stripe disposed proximally adjacent to the second stripe;
a device having a hub including a sidewall having an inside surface defining a cavity, an open proximal end, and a distal end having an opening therethrough in fluid communication with the cavity; the hub of the device attaches to the fluid storage container;
a first indicating element having a distal end attached to the distal end of the hub and a free proximal end extending into the cavity, the first indicating element forming a peripheral recess with the sidewall of the hub; and
a second indicating element disposed in the cavity of the hub including an open proximal end, an open distal end and a body extending from the open proximal end of the second indicating element to the open distal end, the body having an inside surface defining a hollow interior for enveloping the first indicating element to permit the body to enter the recess of the hub upon application of a force to the hub in a proximal direction relative to the fluid storage container, wherein the hub attaches to the fluid storage container such that visibility of the second stripe and the third stripe indicates optimal engagement of the hub to the fluid storage container.

US Pat. No. 10,426,898

RETRACTABLE NEEDLE ASSEMBLIES

Owen Mumford Limited, (G...

1. A retractable needle assembly comprising:a body portion;
a needle having a patient end and being movable between an operational position in which the needle extends along a longitudinal needle axis with the patient end projecting forwardly from the body portion, and a safe position in which the patient end is retracted into the body portion;
a deflector element rotatable about a deflector rotary axis generally perpendicular to the longitudinal needle axis to move the needle to its safe position, and
a manually operated deflector lever connected to or forming part of the deflector element, the manually operated deflector lever projecting from the body portion and intersecting a plane perpendicular to the deflector rotary axis and containing the longitudinal needle axis, the manually operated deflector lever rotates about the deflector rotary axis, from a first position perpendicular to the longitudinal needle axis to a second position parallel to the longitudinal needle axis, to fully retract the needle.

US Pat. No. 10,426,897

CONTAINER HOLDER ASSEMBLY FOR A MEDICAMENT DELIVERY DEVICE AND MEDICAMENT DELIVERY DEVICE COMPRISING THE CONTAINER HOLDER ASSEMBLY

Carebay Europe LTD, Slie...

1. Container holder assembly for a medicament delivery device, which container holder assembly comprises;a housing part, fixedly mounted relative to a longitudinally elongated housing;
a container holder for accommodating a medicament container, which container holder is longitudinally movable relative to the housing part from a distal, initial position to a proximal, end position;
a spring-biased needle guard, coaxial with the container holder and releasably connected with the container holder, and longitudinally movable relative to the housing part between an extended position and a retracted position;
wherein the housing part is coaxially arranged between the container holder and the needle guard,
wherein the housing part comprises a first longitudinal slit through which the needle guard is connected with the container holder,
wherein the needle guard is connected with the container holder by a first connecting member of the needle guard radially biasing a resilient second connecting member of the container holder,
wherein the needle guard is configured to disconnect from the container holder upon movement from the extended position to the retracted position, and
wherein, when the needle guard is connected to the container holder, the second connecting member is radially biased into engagement with a holding member of the housing part, such that the container holder is prevented from longitudinal movement relative to the housing part.

US Pat. No. 10,426,896

MEDICINE INJECTION AND DISEASE MANAGEMENT SYSTEMS, DEVICES, AND METHODS

Bigfoot Biomedical, Inc.,...

1. A pen cap for an insulin pen comprising:one or more sensors adapted to detect a position of a plunger within the insulin pen;
a user interface comprising one or more user-selectable icons or buttons adapted to announce a meal or an intent to have a meal;
a sensor adapted to detect a characterization of the insulin pen or a type of insulin in the insulin pen;
a memory to store information about different types of insulin pens or different types of insulin; and
a processor to determine the type of insulin pen or the type of insulin, wherein the processor is configured to change the user interface dependent on the type of insulin pen or the type of insulin, wherein some types of insulin or insulin pens result in a user-interface that does not include any user-selectable icons or buttons adapted to announce a meal or an intent to have a meal.

US Pat. No. 10,426,895

DRIVE MECHANISM AND DRUG DELIVERY DEVICE HEREWITH

Sanofi, Paris (FR)

1. A drive mechanism for a drug delivery device, the mechanism comprising a spring driven rotatable drive member, a rotatable driven member, a clutch rotationally coupling the driven member and the drive member into a coupled state and allowing relative clockwise and anti-clockwise rotation between the driven member and the drive member when in a decoupled state, and a spring biasing the clutch into the coupled state and allowing relative axial movement between the drive member and the driven member into the decoupled state of the clutch against the bias of the spring, wherein the clutch comprises a first ring of crown teeth on the drive member and a second ring of corresponding crown teeth on the driven member with each crown tooth having in the clockwise and the anti-clockwise direction different ramped tooth angles such that the teeth are allowed to override each other in the de-coupled state of the clutch with a different resistance in the clockwise and the anti-clockwise direction, wherein the drive member is formed of polybutylene terephthalate (PBT), polyoxymethylene (POM), or polycarbonate (PC) and the rotatable driven member is formed of PBT, POM or PC, and a coefficient of friction (?) between the teeth on the drive member and the teeth on the driven member is between 0.05 and 0.3, and the teeth on the drive member and the teeth on the driven member have a surface roughness (Ra) of 0.2?Ra?10 micrometers.

US Pat. No. 10,426,894

DRUG DELIVERY DEVICE WITH INDICATOR

INSULET CORPORATION, Act...

1. An apparatus, comprising:a drug container configured to hold a liquid drug;
a plunger positioned in the drug container;
a drive system coupled to the plunger, the drive system configured to advance the plunger to expel a portion of the liquid drug from the drug container for delivery to a patient, the drive system comprising one or more spherical elements and a drive spring;
a Hall effect sensor positioned adjacent to the drug container; and
a controller coupled to the Hall effect sensor,
wherein the Hall effect sensor is configured to measure a varying magnetic field caused by the one or more spherical elements passing the Hall effect sensor,
wherein the Hall effect sensor is configured to generate a signal indicative of the measured varying magnetic field,
wherein the controller receives the signal generated by the Hall effect sensor and determines a count of a number of the one or more spherical elements that pass the Hall effect sensor.

US Pat. No. 10,426,893

DRUG DELIVERY DEVICE WITH THREADED HOUSING AND PISTON, AND METHOD FOR MANUFACTURING THE SAME

Sanofi, Paris (FR)

1. A drug delivery device for selecting and dispensing a number of user variable doses of a medicament, the drug delivery device comprising: a housing defining a longitudinal axis and having a tubular portion with an inner thread, a piston rod having a threaded portion and a distal end, and a bearing having a distal face and a proximal face, wherein the bearing comprises a retaining stem protruding from the proximal face, wherein the piston rod comprises a distal portion having an outer diameter which is smaller than an inner diameter of the inner thread of the tubular portion, and, a retaining clip engaging the retaining stem at a distal end of the piston rod, and wherein an axial length of the tubular portion is smaller than or equal to an axial distance between the proximal face of the bearing and the distal end of the threaded portion of the piston rod.

US Pat. No. 10,426,892

MOTORIZED DRUG DELIVERY DEVICE

SHL Medical AG, Zug (CH)...

1. A motorized drug delivery device configured to administer at least one pre-set dose of a medicament contained within a medicament container, the delivery device comprising:a user activation system;
a motor;
a gear train operatively coupled to the user activation system and the motor;
a piston plunger system operatively coupled to the gear train, the piston plunger system comprising a piston plunger and at least one plunger extension for extending a length of the piston plunger;
wherein the piston plunger system is configured to act on a stopper contained within the medicament container to deliver at least one pre-set dose of medicament,
wherein the user activation system comprises a mechanical automatic reset activation system that automatically resets the drug delivery device after administration of the pre-set dose, and wherein the mechanical automatic reset activation system includes a dispense button operatively coupled to a hook release.

US Pat. No. 10,426,891

DISPOSABLE CASSETTE FOR STORING AND DELIVERING A MEDICAL DRUG

1. An injector device comprising:a housing defining a cavity having a disposable cassette arranged therein, said housing comprising a movable lid allowing the disposable cassette to be inserted into or removed from the cavity,
a movable sledge configured to operate a valve block of the disposable cassette arranged in the cavity, and
a plunger activator arranged in abutment with a plunger of a cartridge of the disposable cassette arranged in the cavity, the plunger activator being configured to operate the plunger in order to cause a medical drug to be delivered,
wherein the disposable cassette comprises:
the cartridge containing the medical drug,
a waste reservoir arranged to receive waste liquid and/or gas,
an injection needle or an injection needle mounting interface for mounting an injection needle arranged to deliver the medical drug, and
the valve block being movable between a first position and a second position, the first position establishing a fluid passage between the cartridge and the waste reservoir, while preventing fluid flow from the cartridge to the injection needle or the injection needle mounting interface, and the second position establishing a fluid passage between the cartridge and the injection needle or the injection needle mounting interface, while preventing fluid flow from the cartridge to the waste reservoir,
wherein the cartridge, the waste reservoir, the valve block and at least part of the injection needle or the injection needle mounting interface are arranged inside a cassette housing of the disposable cassette, and wherein the valve block is operable to be moved between the first position and the second position without a user operating the disposable cassette coming into direct contact with parts arranged inside the cassette housing.

US Pat. No. 10,426,890

DRUG DELIVERY DEVICE

Sanofi-Aventis Deutschlan...

1. A drug delivery device comprising:a primary drug delivery assembly with a primary dose dial sleeve configured to move proximally in a helical movement during setting of a dose of a primary medicament contained in a primary reservoir of the primary drug delivery assembly and a secondary drug delivery assembly with a secondary drive sleeve configured to move in a proximal direction in a helical movement during setting of a dose of a secondary medicament contained in a secondary reservoir of the secondary drug delivery assembly
a selection switch movable between a first position, a second position, and a third position, wherein the first position is an intermediate position between the second position and the third position; and
a clutch connected to the selection switch such that movement of the selection switch causes rotation of the clutch,
wherein the clutch is configured to engage with and to transfer rotation to the secondary drive sleeve when the selection switch is moved from the first position into the second position such that the dose of the secondary medicament is set and to disengage from the secondary drive sleeve when the selection switch is moved from the first position into the third position such that the dose of the secondary medicament is not set, and
wherein a first engagement element is configured to rotate the primary dose dial sleeve in one direction to set the dose of the primary medicament, wherein the first engagement element is adapted to be engaged by the selection switch such that movement of the selection switch from the first position into the second position and from the first position into the third position causes the first engagement element to rotate the primary dose dial sleeve in the one direction such that a predetermined dose of the primary medicament is set.

US Pat. No. 10,426,889

OPTICAL DISPLACEMENT SENSOR FOR INFUSION DEVICES

DEKA PRODUCTS LIMITED PAR...

1. A medical fluid dispensing apparatus for pumping an infusible medical fluid to the body of a patient, the medical fluid dispensing apparatus comprising:a piston having an encoded pattern associated therewith; and
an optical sensor, wherein the optical sensor is configured to determine the position of the piston, relative to a fiducial position based on the encoded pattern during delivery regardless of whether the encoded pattern associated with the piston repeats.

US Pat. No. 10,426,888

METHOD AND SYSTEM FOR DOSE RATE REGULATION IN DRUG INFUSION TREATMENT

PHARMACOLOG I UPPSALA AB,...

1. A system for administering a drug solution by infusion, comprising:a drug container (1, 2) containing a label drug solution with a label concentration of a drug,
a drug delivery set comprising a fluid conduit (4, 6) connected to the drug container (1, 2), means for connecting the fluid conduit (4, 6) to a patient (8), a detection chamber in the fluid conduit (4, 6) between the drug container (1, 2) and the patient connection means, and adjustment means for setting an infusion rate corresponding to a predetermined dose rate of the drug based on the label concentration,
analytical detection means (5) for non-invasive determination in the detection chamber of the identity and concentration of the drug in fluid withdrawn from the drug container into to the fluid conduit, and
means (7) for preventing infusion of drug solution from the drug container if the label drug is not identified, and
a control unit (10) arranged to control the adjustment means and configured to calculate and set the adjustment means to an adjusted infusion rate in order to maintain the predetermined dose rate when the drug concentration determined in the detection chamber deviates from the label concentration of the drug,wherein said system further comprises a blood analysis system to measure the biological response to the actual dose rate, wherein information obtained therefrom is used as a variable in the dose rate setting.

US Pat. No. 10,426,887

HANDLE FOR MOBILE STAND FOR USE WITH INTRAVENOUS DELIVERY OF MEDICATIONS

Pedigo Products, Inc., V...

1. A handle for an IV stand having a pole, the handle comprising:a connector portion configured to be mounted to the pole; and
a handle grip connected to the connector portion, the handle grip comprising a central section positioned between first and second side sections, the first side section extending upwardly from the central section to a first end of the handle grip, the second side section extending upwardly from the central section to a second end of the handle grip, the first and second ends being spaced apart from the connector portion, the central section being non-planar with respect to the first and second ends, the central section being positioned lower than the first and second ends, the first and second side sections each being configured to be gripped by a hand of a user, the first side section being configured to position the hand between the central section and the first end, the second side section being configured to position the hand between the central section and the second end.

US Pat. No. 10,426,886

SET OF CONTAINERS FOR USE ON A BLOOD COMPONENT CENTRIFUGAL SEPARATOR

Terumo Kabushiki Kaisha, ...

1. A disposable set of containers for use on a blood component centrifugal separator, said blood component centrifugal separator having a first pump, a second pump and a centrifuge rotor, the disposable set comprising:a separation container adapted to be mounted on the centrifuge rotor and having an inlet port and an outlet port;
a tube in fluid communication with a source of whole blood drawn from a blood donor and in further fluid communication with the separation container and adapted to engage the first pump,
a first container for receiving a predetermined first blood component, among centrifugally separated blood components, together with whole blood, said first container being in fluid communication with the outlet port of said separation container and with the inlet port of said separation container, and
a second tube adapted to engage the second pump and in fluid communication with said first container and said inlet port of said separation container,
a temporary storage container wherein whole blood drawn from the blood donor is temporarily stored, and
a third tube coupled to the temporary storage container further coupled to the outlet port of the separation container and a fourth tube also coupled to the temporary storage container and further coupled between the first container and the second tube and further comprising a fifth tube in fluid communication with said third tube and said first tube such that said second tube is connected to said first tube between said fifth tube and said inlet port of said separation container.

US Pat. No. 10,426,885

METHODS AND SYSTEMS FOR ESTABLISHING RETROGRADE CAROTID ARTERIAL BLOOD FLOW

Silk Road Medical, Inc., ...

1. A system for use in accessing and treating a carotid artery, said system comprising:an arterial access sheath formed of an elongated body sized and shaped to be introduced into a common carotid artery, the arterial access sheath having an internal lumen that can receive blood flow;
a shunt that fluidly communicates with the arterial access sheath, wherein the shunt provides a pathway for blood to flow from the arterial access sheath; and
a flow control assembly mechanically attached to the pathway of the shunt, wherein the flow control assembly defines two or more parallel flow paths and a valve to open or close one or more of the flow paths to selectively direct blood flow through one or more of the flow paths.

US Pat. No. 10,426,884

CARTRIDGES AND SYSTEMS FOR OUTSIDE-IN FLOW IN MEMBRANE-BASED THERAPIES

Novaflux Inc., Princeton...

1. An outside-in flow filtration cartridge, comprising:a housing;
a plurality of fibers contained inside said housing, at least some of said plurality of fibers being hollow and being made of semi-permeable membranes having respective fiber lumens and fiber exteriors;
a first fluid flow compartment comprising said fiber lumens of said hollow fibers; and
a second fluid flow compartment comprising an inter fiber space bordering said fiber exteriors,
wherein said housing comprises a first housing port near a first end of said housing, and a second housing port near a second end of said housing,
wherein said second fluid flow compartment comprises an orbital distributor in communication with said inter fiber space,
wherein said outside-in flow filtration cartridge comprises a lateral-circumferential flow redirector comprising an edge, said edge being located between one of said housing ports and said plurality of fibers, said edge facing in a direction toward said one of said housing ports, wherein said lateral-circumferential flow redirector comprises a first smoothly curved concave surface that extends from said edge and blends smoothly with a first circumferential direction of said orbital distributor, and a second smoothly curved concave surface that extends from said edge and blends smoothly with a second circumferential direction of said orbital distributor, and
wherein said outside-in flow filtration cartridge is constructed to flow blood in the inter fiber space bordering said fiber exteriors.

US Pat. No. 10,426,883

SYSTEMS AND METHODS FOR PRIMING HEMODIALYSIS USING MULTIPLE FLUID SOURCES

Baxter International Inc....

1. A hemodialysis system configured to purge air from a blood circuit, the hemodialysis system comprising:a dialyzer;
a dialysis fluid circuit in fluid communication with the dialyzer via dialysis fluid inlet and outlet lines, the dialysis fluid circuit including
a fresh dialysis fluid pump,
a used dialysis fluid pump,
a first balancing unit including (i) a first fresh dialysis fluid chamber operable with the fresh dialysis fluid pump and (ii) a first used dialysis fluid chamber operable with the used dialysis fluid pump, and
a second balancing unit including (i) a second fresh dialysis fluid chamber operable with the fresh dialysis fluid pump and (ii) a second used dialysis fluid chamber operable with the used dialysis fluid pump;
the blood circuit in fluid communication with the dialyzer and including
an arterial line for removing blood from a patient and delivering the blood to the dialyzer,
a venous line for returning blood from the dialyzer to the patient,
a blood pump operable with the arterial line upstream of the dialyzer,
a physiologically acceptable fluid source in fluid communication with the arterial line upstream of the blood pump, and
a drip chamber located along the venous line; and
an air purging scheme wherein, with the dialysis fluid inlet and outlet lines connected to the dialyzer, air is purged from the blood circuit using dialysis fluid or other physiologically acceptable fluid pumped through the dialysis fluid circuit, in combination with dialysis fluid or other physiologically acceptable fluid from the source introduced directly to the blood circuit.

US Pat. No. 10,426,882

BLOOD RINSEBACK SYSTEM AND METHOD

Baxter International Inc....

1. A hemodialysis system configured to return blood to a patient, the hemodialysis system comprising:a dialyzer;
a dialysis fluid circuit in fluid communication with the dialyzer via dialysis fluid inlet and outlet lines, the dialysis fluid circuit including
a fresh dialysis fluid pump,
a used dialysis fluid pump,
a first balancing unit including (i) a first fresh dialysis fluid chamber operable with the fresh dialysis fluid pump and (ii) a first used dialysis fluid chamber operable with the used dialysis fluid pump, and
a second balancing unit including (i) a second fresh dialysis fluid chamber operable with the fresh dialysis fluid pump and (ii) a second used dialysis fluid chamber operable with the used dialysis fluid pump;
a blood circuit in fluid communication with the dialyzer and including
an arterial line for removing blood from a patient and delivering the blood to the dialyzer,
a venous line for returning blood from the dialyzer to the patient,
a blood pump operable with the arterial line upstream of the dialyzer,
a medical fluid source in fluid communication with the arterial line between a patient end of the arterial line and the blood pump,
a drip chamber located along the venous line;
a blood detector operable with the venous line; and
a blood rinseback scheme wherein, with the dialysis fluid inlet and outlet lines connected to the dialyzer, blood is pushed to the patient via the medical fluid being introduced from its source into the arterial line between the arterial line patient end and the blood pump, and flowed through the dialyzer, through the venous drip chamber and to the blood detector along the venous line, where the medical fluid is sensed by the blood detector to indicate an end of the blood rinseback.

US Pat. No. 10,426,881

ENHANCED BACKFLOW PREVENTION IN A HEMODIALYSIS DEVICE

Fresenius Medical Care Ho...

1. A hemodialysis system, comprising:a hydrochamber adapted to heat and remove air from water and to provide backflow protection, the hydrochamber including a first inlet located at a top portion thereof and a second inlet located at a bottom portion thereof;
a water circuit for water to flow from an external water source into the hydrochamber via a water inlet valve, the water inlet valve being connected to the first inlet located at the top portion of the hydrochamber via a first fluid flow path;
a spent dialysate circuit for a disinfecting agent to flow to the hydrochamber via a recirculation valve during a disinfectant operation; and
a drain valve disposed in the spent dialysate circuit;
wherein during the disinfectant operation, the hemodialysis system is adapted to replace a volume of the disinfecting agent exiting the spent dialysate circuit via the drain valve with a substantially equal volume of water via the water inlet valve; and
wherein the recirculation valve is directly connected to the hydrochamber via a second fluid flow path connected to the second inlet located at the bottom portion of the hydrochamber, the second fluid flow path being separate and independent of the first fluid flow path such that in response to a pressure drop at the external water source, the disinfecting agent is prevented from back-flowing through the water inlet valve.

US Pat. No. 10,426,880

VENTRICULAR ASSIST DEVICE AND METHOD

MI-VAD, INC., Rochester,...

1. A ventricular assist device for a human heart comprising:a flow housing having a generally cylindrical wall with an inner surface defining a portion of a flow path, the flow housing having an outer surface and sized for placement within a blood vessel;
a stator disposable within the flow housing, the stator having a plurality of support struts operatively coupling the stator to the flow housing;
a rotor including an outer surface facing the inner surface of the cylindrical wall of the flow housing, the rotor rotatably coupled to the stator and rotatable with respect to the stator about a rotational axis, the rotor defined in part by at least one blade angled with respect to the rotational axis;
one of the rotor and the stator comprising a field magnet and the other of the rotor and the stator comprising windings;
a power source operatively coupled to the windings;
a controller operatively coupled to the power source to selectively control the power source to vary the rotational speed of the rotor; and
a vascular graft surrounding the flow housing and coupled to the flow housing, the vascular graft sized for placement within the blood vessel and arranged for coupling to the blood vessel.

US Pat. No. 10,426,879

BLOOD PUMP WITH RESTART LOCKOUT

HeartWare, Inc., Miami L...

1. A control circuit for controlling operation of an implantable blood pump, the control circuit comprising:an interface;
a pump shutdown module in communication with the interface, the interface being configured to provide one or more inputs indicating at least from the group consisting of an operational error at the implantable blood pump and an adverse physiological state of a user of the implantable blood pump, the pump shutdown module being configured to cease operation of the implantable blood pump in response to the one or more inputs;
a pump restart module configured to resume operation of the implantable blood pump in response to a first pump restart input and a second pump restart input different from the first pump restart input, the first pump restart input and a second pump restart input being provided by the interface; and
a pump restart lockout module configured to initiate a pump lockout mode in response to a lockout input provided by the interface, the pump lockout mode:
preventing resumption of operation of the implantable blood pump in response to the first pump restart input; and
allowing resumption of operation of the implantable blood pump in response to the second pump restart input.

US Pat. No. 10,426,877

BREAST MILK EXPRESSION APPARATUS AND SYSTEM

IMALAC, INC., Miami, FL ...

1. A breast milk expression apparatus comprising:an outer shell;
a plurality of circumferentially spaced inner pads coupled to the outer shell, the plurality of pads disposed under the outer shell, each pad having a radially inner concave surface configured to engage a breast of a user, and the pads configured for radial displacement, wherein each pad defines a circumferential channel extending longitudinally along a respective axis, and wherein in a configuration where the pads engage the breast of the user, the pads are disposed between the outer shell and the breast;
a compression unit coupled to the plurality of pads, configured to cyclically displace the pads radially inwardly against the breast to cause compression of the breast and, following compression of the breast, permitting the breast to expand and decompress, wherein the compression unit includes:
a cable banded about and extending longitudinally and coaxially through each circumferential channel of the plurality of pads, wherein the circumferential channels permit relative longitudinal movement of the cable relative to the pads, and
a drive unit coupled to the cable and the outer shell, the drive unit configured to tighten the cable about the pads to cause the pads to compress the breast and configured to loosen the cable about the pads, permitting the breast to expand and decompress.

US Pat. No. 10,426,876

BREST PUMP DEVICE

Vesucta ApS, Aarhus N (D...

1. A breast pump kit comprising: an electrical driving unit and a breast pump collection system, the breast pump collection system being completely separate from the driving unit and configured to be combined to the driving unit by a user, the breast pump collection system being detachable from the driving unit; wherein the breast pump collection system comprises: a breast shield for placing on a breast of a user, a pump unit, and a tubing connecting the breast shield to the pump unit, wherein the pump unit comprises a compartment of a variable volume and in fluid connection to an exterior only via the tubing, wherein the driving unit comprises at least two attachment means spaced apart by a distance that changes with a driving motion of the driving unit, and wherein the pump unit is configured to be detachably combined to the driving unit by placing the pump unit in engagement with the attachment means such that the driving motion of the driving unit acts to alternatingly expand and contract the compartment of the pump unit, the pump unit thereby creating alternating suction and pressure in the breast shield and at the breast of the user when in use; and wherein the pump unit comprises a bellows and is manufactured as a single-unit component.

US Pat. No. 10,426,875

WOUND CLEANSING APPARATUS IN-SITU

1. A negative pressure wound therapy system, comprising:a wound dressing comprising:
a backing layer comprising an opening and a proximal, wound-facing face and a distal face;
a lower permeable layer configured to contact a wound; and
a chamber between the backing layer and the lower permeable layer; and
a resiliently flexible filler positioned within the chamber, the resiliently flexible filler comprising an absorbent material configured to retain wound exudate within the chamber;
a fluid outlet conduit configured to provide fluid communication between a negative pressure source and the wound dressing, the fluid outlet conduit being in fluid communication with the chamber of the wound dressing; and
a connector attached to the backing layer and forming a seal around the opening in the backing layer, wherein the connector is configured to connect the fluid outlet conduit to the wound dressing; and
a porous material positioned in the flow path between the chamber and the negative pressure source and configured to prevent passage of the wound exudate from the chamber into the fluid outlet conduit.

US Pat. No. 10,426,874

WOUND MANAGEMENT ASSEMBLY AND NEGATIVE PRESSURE WOUND THERAPY SYSTEM

APEX MEDICAL CORP., New ...

1. A wound management assembly for promoting removal of fluid from a wound, comprising:a housing comprising an inlet portion, an outlet and a side wall;
an exudate collector received in the housing; and
a gap defined between the housing and the exudate collector to form a channel for fluid passage;
wherein the fluid passes into and through the exudate collector and radially enters the channel;
wherein the housing defines a chamber therein for receiving the exudate collector, and the inlet portion and the outlet are in communication with the chamber; and
wherein the side wall encompasses the exudate collector, and the exudate collector is surrounded by the channel.

US Pat. No. 10,426,873

EVACUATION SYSTEM

Nascent Surgical, LLC, E...

1. An evacuation system for surgical settings comprising:a vacuum source configured to generate a negative pressure for delivering a level of suction for removing smoke during open surgery;
a flow regulator device fluidly coupled to the vacuum source, the flow regulator device comprising a vacuum port, an inlet port, and a flow rate adjuster; and
a sensing and control system operatively associated with the vacuum source and the flow regulator and programmed to:
cause delivery of a first level of suction via the flow regulator device based on a target pressure level to be maintained in a body cavity during laparoscopic surgery;
sense a level of pressure at one or more of the vacuum port and the inlet port indicative of a pressure of the body cavity during laparoscopic surgery; and
cause delivery of a second level of suction via the flow regulator device in response to a sensed level of pressure deviating from the target pressure, the first and second levels of suction being non-zero suction levels,
wherein the vacuum port is adapted to fluidly couple to the vacuum source, the inlet port is adapted to fluidly couple to an end effector, the vacuum port and the inlet port are fluidly coupled, and the flow rate adjuster is operable to adjust a level of negative pressure delivered by the vacuum source to the inlet port to a reduced suction level such that the end effector receives a level of active suction for removing smoke from the body cavity during laparoscopic surgery.

US Pat. No. 10,426,872

NERVE REPAIR SCAFFOLDS HAVING HIGH MICROCHANNEL VOLUME AND METHODS FOR MAKING THE SAME

THE REGENTS OF THE UNIVER...

1. A method of making a tissue scaffold for neural tissue growth, the method comprising:admixing (i) a porogen having an average particle size of less than or equal to about 40 ?m with (ii) a polymeric precursor solution comprising a biocompatible and biodegradable polyester polymer precursor and a first solvent, to form a suspension;
contacting a template with the suspension to coat at least one surface of the template;
volatilizing at least a portion of the first solvent to form a coating;
removing the coating from the template; to create a microchannel;
assembling the microchannel inside a sheath with a plurality of other microchannels; and
removing the porogen to form a plurality of porous microchannels disposed within sheath thus creating the tissue scaffold.

US Pat. No. 10,426,871

NANOSTRUCTURE SURFACE COATED MEDICAL IMPLANTS AND METHODS OF USING THE SAME

The Regents of the Univer...

1. A method comprising administering to a subject a composition that comprises a surface or film comprising a vertically oriented array of a plurality of nanotubes or microwells,wherein a bioactive agent is filled into the nanotubes or microwells themselves,
wherein a first end of the array of the plurality of filled nanotubes or microwells is in contact with the surface or film, and
wherein the plurality of nanotubes or microwells is capped with a polymeric erodible capping film to provide for delayed elution of the bioactive agent from within the nanotubes or microwells to the surrounding tissue upon placement in a subject and erosion of the capping film.

US Pat. No. 10,426,870

BIOMATERIALS FOR ENHANCED IMPLANT-HOST INTEGRATION

THE TRUSTEES OF THE UNIVE...

1. A method of treating a subject for ischemia, comprising:(1) providing a patterned biomaterial comprising: at least one cord, formed by embedding cells in a naturally-derived or synthetic scaffolding with a pre-specified architecture and spatially organizing the cells within the scaffolding, wherein the at least one cord comprises endothelial cells; and
(2) implanting the patterned biomaterial into a tissue of the subject, wherein the patterned biomaterial is configured to promote the vascularization of the patterned biomaterial and the tissue of the subject, wherein the structure of the patterned biomaterial has a pre-specified architecture that acts as a template and spatial guidance for the subject's vasculature, such that the subject's vasculature invades and integrates at least partially within the at least one cord.

US Pat. No. 10,426,867

BIOCOMPATIBLE POLYCAPROLACTONE FUMARATE FORMULATIONS

Mayo Foundation for Medic...

1. A scaffold for tissue regeneration, the scaffold comprising:a blend of a polymer having the Formula (I)
H-A1-B-A2-C-A1-B-A2-H  (I)
wherein
A1 is

A2 is

B is —O—X—O— wherein X is selected from the group consisting of ethylene, trimethylene, tetramethylene, pentamethylene, C1-C5alkylethylene,
C1-C5alkyltrimethylene, C1-C5alkyltetramethylene, and C1-C5alkylpentamethylene;
C is

and geometric isomers thereof;
and n is an integer from 1 to 50, and
a polymer having the Formula (II)

wherein
D1 is

D2 is

D3 is

E is —O—X—O— wherein X is selected from the group consisting of propanetriyl, butanetriyl, pentanetriyl, C1-C5alkyl propanetriyl,
C1-C5alkyl butanetriyl, and C1-C5alkyl pentanetriyl;
F is
and geometric isomers thereof;and n is an integer from 1 to 50;
wherein the polymer of Formula (I) comprises 20 wt. % to 80 wt % of the scaffold, and the polymer of Formula (II) comprises 20 wt. % to 80 wt % of the scaffold, and
wherein the polymer of Formula (I) is formed using a first initiator such that B is —O—X—O— wherein X is selected from the group consisting of ethylene, trimethylene, tetramethylene, pentamethylene, C1-C5alkylethylene, C1-C5alkyltrimethylene, C1-C5alkyltetramethylene, and C1-C5alkylpentamethylene, and
wherein the polymer of Formula (II) is formed using a second initiator such that E is —O—X—O— wherein X is selected from the group consisting of propanetriyl, butanetriyl, pentanetriyl, C1-C5alkyl propanetriyl, C1-C5alkyl butanetriyl, and C1-C5alkyl pentanetriyl, and
wherein the first initiator is different from the second initiator.

US Pat. No. 10,426,864

STORAGE APPARATUS HAVING AIR PURIFYING MODULE

SEOUL VIOSYS CO., LTD., ...

1. An air purifying system including,a case having a top surface that is flat, a bottom surface opposite to the top surface, and a side surface connecting the top surface and the bottom surface;
an air inlet arranged on the bottom surface to introduce an air from an exterior of the case to an interior of the case;
a circulation fan arranged inside the case and disposed to receive the air from the air inlet and to generate an air flow moving in a first direction, wherein the top surface of the case is connected to the side surface though a rounded corner structured to cause at least a portion of the generated air flow to change an air flow direction to a second direction, the air moving in the second direction along the top surface,
a light emitting diode part arranged above the air inlet and including a light emitting diode positioned to sterilize the air flow moving in the second direction;
an air outlet positioned to discharge the air to the exterior of the case; and
a collection filter arranged in the case and configured to capture bacteria to increase a sterilization efficiency of the air purifying system,
wherein the first direction is toward the top surface and the second direction is substantially perpendicular to the first direction.

US Pat. No. 10,426,863

LIQUID SPRAY DEVICE WITH CONCEALED ELECTRIC CONDUCTIVE STRUCTURE

Vida International Inc., ...

1. A liquid spray device with a concealed electric conductive structure, which is used for atomizing and then spraying a liquid stored therein, comprising:a base;
a control means arranged on a front side of the base;
a liquid storage means separately arranged above or below the control means, and provided with a liquid sucking outlet;
a spray unit comprising a bracket and a vibrator arranged on the bracket, wherein the bracket is movably pivoted on the control means, and the vibrator abuts against the liquid sucking outlet of the liquid storage means via the movement of the bracket; and
a housing separately connected to the base to cover the control means and the spray unit, wherein a spray opening is provided at a location corresponding to the vibrator, and wherein a conductive pivoting structure is provided between the control means and the bracket, the bracket is provided with a wire recess, a wire is arranged within the wire recess, one end of the wire is electrically connected to the conductive pivoting structure, and the other end of the wire is electrically connected to the vibrator.

US Pat. No. 10,426,862

DIFFUSING APPARATUS AND METHODS

SPDI Holdings, Inc., Alp...

1. A diffusing apparatus for diffusing essential oils into the air, the apparatus comprising:a reservoir configured to hold essential oils in an internal cavity;
a controller assembly removably coupled to the reservoir, the controller assembly comprising an air inlet port, a first controller, and a micro air pump unit;
a base communicably connected to the controller assembly, the base comprising a second controller, wherein the second controller is communicably connected to the first controller; and
a tube in fluid connection at a first end with the micro air pump unit and extending into the reservoir, the tube providing a path for pressurized air from the micro air pump unit into the reservoir through a plurality of orifices at a second end of the tube.

US Pat. No. 10,426,860

AROMA DIFFUSER AND OIL SUPPLY METHOD

Shenzhen NearbyExpress Te...

1. An aroma diffuser, comprising:a main body, provided therein with a liquid storage chamber, the liquid storage chamber being configured to store a liquid; and
an oil storage tube configured to store an essential oil,
wherein when the aroma diffuser works, a bottom portion of the oil storage tube is in fluidic communication with the liquid storage chamber, allowing the essential oil in the oil storage tube to flow from the bottom portion of the oil storage tube into the liquid storage chamber as the liquid in the liquid storage chamber is being consumed.

US Pat. No. 10,426,859

DEVICE FOR RELEASING VOLATILE SUBSTANCES

ZOBELE ESPANA, S.A., Bar...

1. A device for releasing volatile substances comprising a container containing the volatile substances located in a fixed position and means for generating an air flow in order to release the volatile substances, wherein said means for generating an air flow comprise:a movable body, the movement of which generates the air flow, wherein said movable body is a sheet which swivels with respect to a shaft;
at least one magnet arranged on said movable body on an end opposite to the swivel end of said sheet; and
means for generating magnetic flux the actuation of which causes the displacement of said movable body by the repulsion force between said at least one magnet on the movable body and said magnetic flux.

US Pat. No. 10,426,858

DEVICE FOR RELEASING VOLATILE SUBSTANCES

Zobele Espana, S.A., Bar...

1. A device for releasing volatile substances comprising:a support (9) for positioning a receptacle (3) containing the volatile substances; and
means for generating a flow of air for releasing the volatile substances, wherein said means for generating a flow of air comprise:
a mobile body (1) joined to said support (9);
at least one magnet (2) disposed in said mobile body (1); and
means for generating a magnetic flux (4, 5) disposed close to the mobile body (1) in at least one position amongst one or more positions of said mobile body (1) and that comprise a detector (5) that drives the generation of magnetic flux upon detecting the magnet (2) or one of the magnets (2) of said mobile body (1), the operation of which causes the movement of said mobile body (1) by means of the repulsive force between said at least one magnet (2) in the mobile body (1) and the magnetic flux,
wherein said mobile body (1) is a rotary disc with respect to its center.

US Pat. No. 10,426,857

SYSTEMS, DEVICES, AND METHODS INCLUDING IMPLANTABLE DEVICES WITH ANTI-MICROBIAL PROPERTIES

Gearbox, LLC, Bellevue, ...

1. An insertable device, comprising:a body structure having an outer surface and an inner surface defining one or more fluid-flow passageways;
circuitry configured to detect one or more microorganisms present proximate at least one of the outer surface, the inner surface, or the one or more fluid-flow passageways; and
one or more actively controllable anti-microbial regions included on at least one of the outer surface or the inner surface, or embedded in the body structure, at least one of the one or more actively controllable anti-microbial regions having a wettability switchable feature configured to actuate between a first anti-microbial state and a second anti-microbial state responsive to detection of at least one microorganism by the circuitry.

US Pat. No. 10,426,856

DECONTAMINATION SYSTEM

AIREX CO., LTD., Nagoya-...

1. A decontamination system for decontaminating, with respect to one or more rooms targeted to be decontaminated, an inside of each room targeted to be decontaminated, by using decontamination gas, the decontamination system comprising compressed air-generating means for generating compression air; decontamination solution-supplying means for supplying decontamination solution;mixed gas-liquid adjusters to adjust, with respect to each room targeted to be decontaminated, decontamination mixed gas-liquid obtained by respectively mixing the compression air and the decontamination solution;
gas generators to gasify the mixed gas-liquid to generate decontamination gas;
air supplying pipes which communicate from the compressed air-generating means up to each of the mixed gas-liquid adjuster;
decontamination solution supplying pipes which communicate from the decontamination solution-supplying means up to each of the mixed gas-liquid adjuster; and
mixed gas-liquid supplying pipes which communicate from each mixed gas-liquid adjuster up to a corresponding gas generator of the gas generators,
characterized in that the compressed air-generating means, the decontamination solution-supplying means, and each respective mixed gas-liquid adjusters are arranged at positions which are spaced from each room targeted to be decontaminated, and each of the gas generators is arranged near or in each of the one or more rooms targeted to be decontaminated that corresponds thereto, and
a conveyance distance of each mixed gas-liquid supplying pipe with respect to each room targeted to be decontaminated is thereby longer than a conveyance distance of each of the decontamination solution supplying pipes that corresponds thereto.

US Pat. No. 10,426,855

SYSTEM AND METHOD FOR THE DECONTAMINATION OF INDOOR AIR AND SURFACES HAVING BIOLOGICAL, CHEMICAL OR PHYSICAL CONTAMINATION

1. A system for the decontamination of indoor air and surfaces having biological, chemical or physical contamination;a housing including a base unit and a cover hingedly secured thereto;
said base unit including:
(a) a back wall having an upper end, a lower end, a first side, a second side, a front side and a rear side;
(b) a first side wall extending forwardly from said first side of said back wall and having an upper end, a lower end, a front end, a rear end, an inner surface and an outer surface;
(c) a second side wall extending forwardly from said second side of said back wall and having an upper end, a lower end, a first end, a rear end, an inner surface and an outer surface;
(d) a top wall extending forwardly from said upper end of said back wall and having a back end, a front end, a first end, a second end, an inner surface and an outer surface;
(e) a bottom wall extending forwardly from said lower end of said back wall and having a back end, a front end, a first end, a second end, an inner surface and an outer surface;
(f) said first side wall of said base unit having an air inlet opening formed therein;
said cover including:
(a) a front wall having an upper end, a lower end, a first side, a second side, a front side and a rear side;
(b) said first side of said cover being hingedly secured to said second side wall of said base unit whereby said cover may be selectively hingedly moved with respect to said base unit between a closed position and an open position;
(c) said cover having first, second and third openings formed therein;
an ozone gas generator positioned in said base unit;
said ozone gas generator having an air inlet opening formed therein which is in communication with said air inlet opening of said base unit;
said ozone gas generator having an ozone gas discharge tube extending therefrom;
an electrical power cord extending from a source of electrical power into said base unit;
said power cord being electrically connected to said ozone gas generator to power the same;
an electrical timer positioned in said first opening of said cover;
an electrical switch positioned in said second opening of said cover;
an electrical operated exhaust fan assembly positioned in said third opening of said cover;
said exhaust fan assembly having a discharge side which is in communication with the area around said housing;
said exhaust fan assembly having an air intake side which is in communication with said base unit when said cover is in its said closed position whereby the ozone gas generated by said ozone gas generator will be exhausted from said housing through said discharge side of said exhaust fan assembly; and
said switch being electrically connected to said power cord, said ozone gas generator, said timer and said exhaust fan assembly so as to be able to control the operation of said ozone gas generator, said timer and said exhaust fan assembly.

US Pat. No. 10,426,854

APPARATUS AND METHOD TO MAKE HIGH LEVEL DISINFECTANT

Medivators Inc., Minneap...

1. An apparatus to make a peracetic acid high level disinfectant solution comprising:a) a solid dispensing system comprising a bulk dispenser for a solid mixture of TAED, a bulk dispenser for a solid mixture of sodium percarbonate, and a bulk dispenser for solid citric acid monohydrate,
b) a heated water delivery system,
c) a first reactor chamber to mix solid TAED and solid sodium percarbonate with heated water to provide a first peracetic acid solution,
d) a first conduit to deliver heated water from the heated water system to the first reactor chamber,
e) a second reactor chamber to mix the first peracetic acid solution with solid citric acid monohydrate to provide a pH controlled peracetic acid solution,
f) a second conduit to deliver the peracetic acid solution from the first reactor chamber to the second reactor chamber,
g) a storage reservoir to dilute the pH controlled peracetic acid solution with water to provide the peracetic acid high level disinfectant solution,
h) a third conduit to deliver the pH controlled peracetic acid from the second reactor chamber to the reservoir, and
i) a fourth conduit to deliver water to the storage reservoir.

US Pat. No. 10,426,853

APPARATUS TO CONTROL REACTION OF PEROXIDE AND ALKALINE

1. An apparatus for supplying a peroxide composition and an alkaline composition simultaneously for removal and destruction of microbiological and organic contamination on a surface comprising:a power module;
a means to activate the power module;
a pump connected to the power module;
a pump intake line, wherein one end of the pump intake line is connected to the pump and the other end is connected to at least one pump check valve system, wherein each pump check valve system further comprises:
a pump check valve, wherein the pump check valve is attached to the pump intake line and a check valve line,
a solenoid valve, wherein the solenoid valve is connected to the check valve line and composition input line,
a composition pick up tube, wherein the composition pick up tube is connected to the composition intake line and an input check valve, and the input check valve is connected to a filter screen, wherein the input check valve and filter screen are within a reservoir, and wherein the reservoir of at least one pump check valve system contains hydrogen peroxide;
a pump discharge line connected to the pump;
an injector connected to the pump discharge line;
an injector intake line, wherein the injector intake line is independent of the pump intake line and the at least one pump check valve system, and one end of the injector intake line is connected to the injector and the other end is connected to an injector valve system, wherein the injector valve system is independent of the pump intake line and the at least one pump check valve system, and the injector valve system further comprises:
a solenoid valve, wherein the solenoid valve is attached to the injector intake line and a composition intake line,
a composition pick up tube, wherein the composition pick up tube is connected to the composition intake line and an input check valve, and the input check valve is connected to a filter screen, wherein the input check valve and filter screen are within an injector reservoir that contains an alkaline composition;
a metering device, wherein the metering device is located at the intersection of the injector and the injector intake line;
an injector output line, wherein one end of the injector output line is connected to the injector and the other end is connected to a spray line;
a one way check valve, wherein the one way check valve is connected to the spray line and a handheld spray wand,
wherein the power module further comprises a means to activate the solenoid valves individually and a means to activate the pump.

US Pat. No. 10,426,852

ULTRAVIOLET-BASED DETECTION AND STERILIZATION

Sensor Electronics Techno...

1. A system comprising:a disinfection chamber comprising:
a plurality of ultraviolet sources configured to irradiate an object located within the disinfection chamber from a plurality of directions, wherein at least some of the plurality of ultraviolet sources emit UV-C electromagnetic radiation;
a set of visible light sources configured to irradiate the object with visible light from a set of directions; and
a set of cameras configured to acquire image data of the object from a plurality of directions; and
a computer system including a set of computing devices, wherein the computer system is configured to perform a sterilization procedure for the object, wherein the sterilization procedure includes operating the plurality of ultraviolet sources and the set of visible light sources using the image data to evaluate shadow data to ensure that the plurality of ultraviolet sources deliver a dose of ultraviolet radiation onto each exterior surface of the object sufficient to result in at least a log reduction of a target contaminant.

US Pat. No. 10,426,851

PROTECTIVE STERILIZATION SYSTEM

1. A protective sterilization system comprising:a protective container, having:
a first casing member having a body forming a storage space having:
the body extending from a first enclosed end to a first open end, the first enclosed end having at least a first side, a second side, and a third side, the third side being opposite the first open end and extending between the first side and the second side;
a bottom surface; and
a first protection device positioned within the storage space at the first enclosed end of the body and attached to at least the first side, the second side, and the third side of the first enclosed end and extending inwardly into the storage space from at least the first side, the second side, and the third side of the first enclosed end;
a plurality of support arms rigidly attached to the bottom surface of the storage space and configured to suspend an implement within the storage space of the container; and
a second casing member having a second enclosed end and a second open end and configured to removably attach to the first casing member at the first open end of the first casing and the second open end of the second casing member via tongue and grooves, the second casing member having:
a second protection device extending from the second enclosed end configured to hold the implement in a stationary position;
wherein the container when closed is sterilized to clean the implement.

US Pat. No. 10,426,850

COLLAGEN MIMETIC PEPTIDES FOR TARGETING COLLAGEN STRANDS FOR IN VITRO AND IN VIVO IMAGING AND THERAPEUTIC USE

THE JOHNS HOPKINS UNIVERS...

1. A collagen mimetic peptide (CMP) having the formula:L-S-[Gly-X-Y]n-Gly-X-Y-[Gly-X-Y]n; wherein
L is IRDye-800CW or IRDye 680RD;
S is aminohexanoic acid;
X is proline;
Y is hydroxyproline;
Gly is glycine; and
n is 4.

US Pat. No. 10,426,843

DELTA-OPIOID RECEPTOR TARGETED AGENT FOR MOLECULAR IMAGING AND IMMUNOTHERAPY OF CANCER

1. A compound having Formula I,
wherein
n is an integer of from 1 to 50;
L1 and L2 are optional linking moieties of from 1 to 100 atoms in length; and
Ab is an antibody;
Tg* is H, a protecting group, or a detectable moiety; and
Dmt-Tic is represented by

where R1 and R2 are independently selected from H and CH3.

US Pat. No. 10,426,842

TARGETED NANOPARTICLE CONJUGATE AND METHOD FOR CO-DELIVERY OF SIRNA AND DRUG

The Curators of the Unive...

1. A nanoparticle conjugate comprising a small interfering RNA (siRNA) covalently linked to an antibody that is bonded to the surface of a gelatin nanoparticle that physically encapsulates a drug, wherein one end of siRNA is coupled to an epidermal growth factor receptor (EGFR) targeting monoclonal antibody via a thio-ether bond, and a lysine functional group present on the antibody is bridged with carboxyl groups present on the gelatin nanoparticle.

US Pat. No. 10,426,838

COMPOSITE PARTICLES INCLUDING CELLULOSE, INORGANIC COMPOUND, AND HYDROXYPROPYL CELLULOSE

ASAHI KASEI KABUSHIKI KAI...

1. A composite particle comprising from 50 to 80 parts by mass of cellulose, from 10 to 40 parts by mass of an inorganic compound and from 4 to 11 parts by mass of hydroxypropyl cellulose based on 100 parts by mass of a total of contents of the cellulose, the inorganic compound, and the hydroxypropyl cellulose.

US Pat. No. 10,426,837

COMPOSITIONS AND METHODS FOR TREATING CNS DISORDERS

Sage Therapeutics, Inc., ...

1. A compound of Formula (I-c):
wherein:
n is 0, 1, 2, 3, 4, or 5;
Ring A is aryl or heteroaryl;
R3A is C1-6 alkyl;
R1 is hydrogen, C1-3alkyl, C2-6 alkenyl, or C3-6 carbocyclyl;
R2 is absent or hydrogen;
Ra is halogen, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, carbocyclyl, heterocyclyl, aryl, heteroaryl, —C(O)RA, —C(O)ORA, —C(O)NRBRc, —S(O)2RD, or —ORY, wherein RY is hydrogen, C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, carbocyclyl, heterocyclyl, aryl, heteroaryl, —C(O)RA, —C(O)ORA, —C(O)NRBRc, or —S(O)2RD;
RA is hydrogen, C1-C6 alkyl, carbocyclyl, heterocyclyl, aryl, or heteroaryl;
each of RB and Rc is independently hydrogen, C1-C6 alkyl, carbocyclyl, heterocyclyl, aryl, heteroaryl, or taken together with the atom to which they are attached form a ring; and
RD is hydrogen, C1-C6 alkyl, carbocyclyl, heterocyclyl, aryl, or heteroaryl.

US Pat. No. 10,426,835

METHOD FOR TREATING PEYRONIE'S DISEASE

BMR Medical LLC, Mariett...

1. A method of treating a patient having a plaque mass associated with Peyronie's disease in a penile region, comprising the steps of:(a) performing a battery of tests to quantify an initial state of parameters associated with Peyronie's disease in the patient;
(b) applying shock wave treatment to the plaque mass in the penile region, thereby softening the plaque mass and disrupting any calcification in the plaque mass wherein the shock wave treatment comprises a low intensity shock wave treatment having a minimum energy of 0.10 mJmm2;
(c) applying carboxy treatment comprising injecting carbon dioxide into the plaque mass after the step of applying the shock wave treatment;
(d) repeating the battery of tests to quantify a current state of parameters associated with Peyronie's disease in the patient and comparing the current state to the initial state; and
(e) until the current state differs from the initial state by at least a predetermined amount, repeating steps (b) through (d).

US Pat. No. 10,426,833

LIQUID PHARMACEUTICAL COMPOSITION

Fresenius Kabi Deutschlan...

1. An aqueous pharmaceutical composition comprising:(a) 45-55 mg/mL adalimumab;
(b) 5-14 mM citrate buffer system;
(c) 100-250 mM sugar stabilizer selected from the group consisting of trehalose and sorbitol; and
(d) 0.05-1.5 mg/mL surfactant selected from the group consisting of polysorbate 80 and polysorbate 20;wherein the composition:has a pH between 5.0 and 6.0;
is free of phosphate buffering agents; and
is free of amino acids selected from the group consisting of arginine, lysine, and aspartic acid; and
comprises at most one sugar stabilizer.

US Pat. No. 10,426,831

ANTIVIRAL VACCINES WITH IMPROVED CELLULAR IMMUNOGENICITY

Beth Israel Deaconess Med...

1. A nucleic acid molecule encoding a polypeptide comprising a sequence at least 99% identical to SEQ ID NO:3.

US Pat. No. 10,426,830

ALTERING THE IMMUNDOMINANCE HIERARCHY USING A DNA VACCINE EXPRESSING CONSERVED REGIONS

THE UNITED STATES OF AMER...

1. A method of inducing an immune response to an HIV protein, the method comprising administering:a first nucleic acid encoding a first conserved element polypeptide, wherein the conserved elements are from the HIV protein and the polypeptide comprises at least six conserved elements, each less than 50 amino acids in length, where the conserved elements are joined by linkers;
a second nucleic acid encoding a second conserved element polypeptide that comprises a variant of each of the at least six conserved elements contained in the first conserved element polypeptide, wherein each variant in the second conserved element polypeptide differs from the corresponding conserved element in the first conserved element polypeptide by at least 1, 2, or 3 amino acids; and
after administration of the first and the second nucleic acids, administering a nucleic acid encoding the full-length HIV protein, or substantially full-length HIV protein, wherein the nucleic acid encoding the full-length HIV protein or substantially full-length HIV protein is administered at least two weeks after the first and second nucleic acids encoding the conserved element polypeptides; and further, wherein the nucleic acid encoding the full-length HIV protein, or substantially full-length HIV protein, is administered as a plasmid that comprises an expression cassette comprising a nucleic acid sequence encoding the full-length HIV protein, or substantially full-length HIV protein, operably linked to a promoter.

US Pat. No. 10,426,785

C-19 STEROIDS FOR INHIBITING NEOVASCULARIZATION

Curadis GmbH, Erlangen (...

1. A method of treating or preventing a pathological condition involving angiogenesis in a patient, the method comprising:administering an effective amount of a compound to the patient, wherein the compound is defined by Formula 1:

wherein:
a, b and c respectively denote, independently from each other, a single bond or a double bond, with the proviso that at least one of a, b and c represents a double bond, and with the proviso that if a is single bond and b is double bond, R2 is not H;
R1 is either hydrogen or C1 to C6 alkyl;
R2 is either OR5 or hydrogen, wherein R5 is hydrogen or C1 to C12 straight chain or branched alkyl;
R3 is, in case of c being a single bond, either hydrogen or C1 to C6 alkyl, or in case of c being a double bond, CHR5, wherein R5 is the same as defined before; and
R4 is hydrogen, C1 to C12 alkyl, phenyl unsubstituted or substituted by C1 to C12 alkyl or COR6 acyl group; R6 being hydrogen, C1 to C12 straight chain or branched alkyl, phenyl or benzoyl, respectively unsubstituted or substituted by C1 to C12 alkyl, or any group leading to hydroxyl upon biological metabolization or chemical deprotection, the group being an ester, ether, acetale, carbonate, ca late, phosphate, phosphonate, ketal, sulfate, or sulfonate; and salts thereof.

US Pat. No. 10,426,784

IMIDAZODIAZEPINE COMPOUND

Astellas Pharma Inc., Ch...

14. A pharmaceutical composition, comprising a compound or a salt thereof according to claim 1 and a pharmaceutically acceptable excipient.

US Pat. No. 10,426,780

ANTIVIRAL THERAPY

ViiV Healthcare Company, ...

1. A combination comprising a compound of formula (I)or a pharmaceutically acceptable salt thereof, and rilpivirine, or a pharmaceutically acceptable salt thereof.

US Pat. No. 10,426,771

6-HYDROXY-2,5,7,8-TETRAMETHYLCHROMAN-COMPOUNDS FOR THE TREATMENT OF CHRONIC OBSTRUCTIVE AIRWAY DISEASES

Sulfateq B.V., Groningen...

1. A method of treating a chronic obstructive airway disease in a subject, the method comprising administering to the subject a compound according to formula (I) or a pharmaceutically acceptable salt thereof,
wherein R1 and R2 are the same or different, and represent a C1-C4 linear or branched alkylgroup;
wherein R3 represents hydrogen;
n is 1;R4 is CO—N—R5; wherein R5 comprises linear or branched alkyl group comprising 1-12 carbon atoms or cyclic alkyl group, substituted with nitrogen or oxygen; and wherein nitrogen is amine, quaternary amine, guanidine or imine, and oxygen is hydroxyl, carbonyl or carboxylic acid, and wherein oxygen and nitrogen together form amide, urea or carbamate groups;wherein the compound is in a formulation suitable for inhalation.

US Pat. No. 10,426,769

PHARMACEUTICAL COMPOSITION FOR PREVENTING AND TREATING OBESITY OR LIVER DISEASES, CONTAING TLR7 AGONIST

KNOTUS CO., LTD., Guri-s...

1. A method of inhibiting liver fat accumulation in mammals in need thereof, comprising administering by intraperitoneal injection to the mammals an effective amount of imiquimod having the following structure as a TLR7 agonist to inhibit liver fat accumulation:

US Pat. No. 10,426,768

SUBCUTANEOUS DELIVERY OF POLYMER CONJUGATES OF THERAPEUTIC AGENTS

Sarina Therapeutics, Inc....

1. A method for treating a disease or condition selected from the group consisting of restless leg syndrome and Parkinson's disease in a subject in need thereof, the method comprising the step of administering to the subject a poly(oxazoline) polymer conjugate comprising a water soluble poly(oxazoline) polymer and an agent, wherein a release profile of the agent is selectable based on the selection of the poly(oxazoline) polymer conjugate, the poly(oxazoline) polymer conjugate having the structure:
wherein
L is

R3 forms a linkage with the poly(oxazoline) polymer;
R4 is —CH2—C(O)—O—, —CH(CH3)—C(O)—O—, —CH2—CH2—C(O)—O—, —CH2—CH2—CH2—C(O)—O—, —CH2—O—C(O)—, —CH(CH3)—O—C(O)—, —CH2—CH2—O—C(O)— or —CH2—CH2—CH2—O—C(O)—;
R is an initiating group;
R1 is a non-reactive group;
A is rotigotine, pramipexole, quinagolide, fenoldopam, apomorphine, 5-OH-DPAT, ropinirole, pergolide, cabergoline, bromocriptine, theophylline, istradefylline, preladenant trihexyphenidyl, biperidin, hyoscyamine, selegiline, rasagiline, tolcapone or entacapone;
a is ran which indicates a random copolymer or block which indicates a block copolymer;
o is from 1-50;
m is from 1-1000; and
T is a terminating group,
wherein the release profile is dependent on the selection of R4.

US Pat. No. 10,426,762

INHIBITORS OF HEPATITIS C VIRUS POLYMERASE

COCRYSTAL PHARMA, INC., ...

1. A compound according to Formula I:
or a pharmaceutically acceptable salt thereof,
wherein:
X is —CH2— and Y is —NR1—;
R1 is —C5-6hydroxyalkyl, —S(O)2—C0-4alkyl-RO, —C0-4alkyl-RO, —C0-3alkyl-C(O)—C0-4alkyl-RO, —C0-3alkyl-C(O)O—C0-4alkyl-RO;
wherein:
RM and RN are independently hydrogen, —C1-4alkyl, or RM and RN together with the atoms to which they are attached can form a 4- to 6-membered ring; and
RO is (a) a 5- to 7-membered cycloalkyl, substituted with a —C1-3alkyl, aryl, —O-aryl, or —NRMRN moiety, (b) a 7-membered cycloalkyl optionally substituted with a hydroxyl, or (c) a 6- to 10-membered aryl, monocyclic or bicyclic, and substituted with one to three moieties independently selected from —C1-4alkyl, halogen, —NRMRN, —C1-4haloalkyl, —C1-4alkoxy, —C1-4hydroxyalkyl, cyano, —O-aryl, and aryl, provided that at least one such substitution is —C1-4alkoxy, —C1-4hydroxyalkyl, cyano, or —O-aryl;
R2 is —C1-5alkyl optionally substituted with 1-5 halogens, —C1-5alkoxy, —C5-7cycloalkyl-C0-3alkyl in which the alkyl is optionally substituted with 1-3 halogens, —C1-4alkyl-C3-5cycloalkyl, or phenyl optionally substituted with 1 or 2 halogens or —C1-3alkyl groups optionally substituted with 1-3 halogens;
R3 is —RA—RB;
wherein RA is a phenyl moiety optionally substituted with one or two Z, in which each Z is independently halogen, —C1-3alkyl, —C1-3haloalkyl, —C1-3alkoxy, or cyano; and
wherein RB is —N(RU)C(O)—RQ;
wherein RQ is a thiazolyl, optionally substituted with one or two RZ, in which each RZ is independently —C1-3alkyl, —C1-3alkoxy, or —NRMRN;
RS and RT are each independently hydrogen or —C1-4alkyl, or one of RS and RT is hydrogen and the other is —C(O)-5- to 9-membered aryl; and
RU is hydrogen or —C1-4alkyl;
provided that, when RA is phenyl, then RB appears at the para or meta position relative to the thiophene moiety; and
R4 is hydrogen, —C1-4alkyl, —C1-4alkyl-OC(O)O—C1-4alkyl, —C1-4alkyl-OC(O)—C1-4alkyl, —C1-4alkyl-OC(O)O—C3-6cycloalkyl, 5-methyl-2-oxo-[1,3]dioxol-4-ylmethyl-, —C0-3alkyl-C5-6aryl, or —C1-4alkyl-NRVRW; and
RV and RW are independently hydrogen or —C1-4alkyl.

US Pat. No. 10,426,760

COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR

Plexxikon Inc., Berkeley...

1. A method for treating a subject with melanoma, thyroid cancer, or colorectal cancer, said method comprising administering to the subject:an effective amount of a compound of formula (Ia):

or a pharmaceutically acceptable salt thereof,
wherein:
L1 is a bond or —N(H)C(O)—;
each R1 is —N(R5)—C(X)—R7, lower alkyl, or optionally substituted heteroaryl;
R2 is hydrogen or halogen;
R4 is hydrogen;
R3 is optionally substituted lower alkyl or optionally substituted aryl;
m is 0, 1, 2, or 3;
Ar is a monocyclic heteroaryl containing 5 to 6 atoms wherein at least one atom is nitrogen;
R5 is hydrogen;
X is O; and
R7 is lower alkyl.

US Pat. No. 10,426,755

METHODS FOR INHIBITING CANCER CELLS

CHANG GUNG MEMORIAL HOSPI...

1. A method for inhibiting cancer cells, comprising:administering to a subject in need thereof a therapeutically effective amount of a compound of formula (I),
or a pharmaceutically acceptable salt thereof,wherein:
R1 to R8 are each independently H, a hydroxyl group, a nitro group, an amino group, a halogen, a substituted or unsubstituted C1-C10 alkyl group, and a substituted or unsubstituted C1-C10 alkoxy group, wherein the C1-C10 alkyl group or the C1-C10 alkoxy group may be substituted by at least one selected from the group consisting of a hydroxyl group, a nitro group, an amino group, a halogen, a substituted or unsubstituted C1-C10 alkyl group, and a substituted or unsubstituted C1-C10 alkoxy group,
wherein the cancer cells are selected from the group consisting of prostate cancer, endometrial cancer, breast cancer and colorectal cancer.

US Pat. No. 10,426,753

SUPRAMOLECULAR COMBINATORIAL THERAPEUTICS

INVICTUS ONCOLOGY PVT. LT...

14. A supramolecular combinatorial therapeutic (SCT) comprising a taxane-lipid conjugate, wherein the taxane-lipid conjugate is a paclitaxel-lipid conjugate or a docetaxel-lipid conjugate; andwherein the paclitaxel-lipid conjugate is selected from the group consisting of conjugate 16 and conjugate 17


wherein the docetaxel-lipid conjugate is selected from the group consisting of conjugates 18-20 and conjugate 33

US Pat. No. 10,426,752

MENTHOL-DERIVATIVE COMPOUNDS AND USE THEREOF AS ORAL AND SYSTEMIC ACTIVE AGENTS

Colgate-Palmolive Company...

1. A method for providing one or more oral care beneficial effects, selected from anti-inflammation and anti-bone loss effects, to a subject in need thereof, comprising administering to the oral cavity of the subject an amount from 0.05 wt. % to 5 wt. % of at least one menthol-derivative compound conforming to Formula 1 to a subject:
wherein
X is an oxygen atom or an NH radical; and
R is an unsubstituted or substituted aryl radical, andin combination with a water-swellable synthetic, anionic, linear copolymeric polycarboxylate.

US Pat. No. 10,426,751

ALLOSTERIC ACTIVATORS FOR TREATMENT OF PHENYLKETONURIA

McMaster University, Ham...

1. A method of restoring phenylalanine hydroxylase activity in mammalian phenylalanine hydroxylase comprising exposing said phenylalanine hydroxylase to shikimic acid, a pharmaceutically acceptable salt of shikimic acid, a functionally equivalent analogue thereof selected from the group of:i) an analogue of shikimic acid having one or more additional substituents on the cyclohexene ring of shikimic acid, wherein the additional substituent is selected from the group consisting of hydroxyl, thio, —OR1, —NH2, NO2, —NHR1, —NR1R2, —SR1 and a C1-C6 alkyl group, C1-C6 alkoxy, and C1-C6 alkanol, wherein R1 and R2 are independently selected from the group consisting of C1-C6 alkyl, C1-C6 alkanol and C1-C6 alkoxy;
ii) an analogue in which one or more of the hydroxyl groups on the cyclohexene ring of shikimic acid is substituted with hydrogen, thio, C1-C6 alkyl, C1-C6 alkanol, C1-C6 alkoxy, —OR1, —NH2, NO2, —NHR1, —NR1R2, or —SR1; and
iii) an analogue in which the cyclohexene ring of shikimic acid is replaced with a cyclohexane ring;or combinations thereof.

US Pat. No. 10,426,745

POLYMERIC METFORMIN AND ITS USE AS A THERAPEUTIC AGENT AND AS A DELIVERY VEHICLE

THE UNIVERSITY OF NORTH C...

1. A nanoparticle comprising:i. a lipid outer membrane; and
ii. a polymer encapsulated by the lipid outer membrane, said polymer having the following chemical formula I

wherein, p is 1 or 2, n is an integer from two (2) to 10,000;
and
wherein, X is hydrogen or a residue of Metformin having the formula:

wherein at least 5% of X in the polymer is a residue of Metformin.

US Pat. No. 10,426,742

FORMULATION AND PROCESS FOR MODULATING WOUND HEALING

BioMendics, LLC, Fairlaw...

1. A method for promoting wound healing in a patient having a wound or skin condition, comprising administering to a patient a therapeutically effective amount of a formulation comprising:a first autophagy modulating compound having the structure (I):

wherein L is a linker comprising —C?C—;
R1 and R2 are independently substituents at any available position of the phenyl rings;
m and n are, independently, 0, 1, 2, or 3 representing the number of substituents on the rings, respectively, and at least one of m or n must be ?1;
wherein each R1 and R2 is independently selected from:
—R5, wherein R5 is selected from (C1-C6)alkyl, (C2-C6)alkenyl, or (C2-C6)alkynyl; optionally substituted with 1 to 3 substituents selected from —OH, —SH, -halo, —NH2, or NO2;
—YR6, wherein Y is O, S, or NH; and R6 is selected from H or R5;
—ZR5, wherein Z is —N(C?O)— or —O(C?O)—;
-halo;
—NO2;
—SO3Na;
-azide; and
-glycosides
-and salts thereof;
with the proviso that the first autophagy modulating compound is not resveratrol or 4,4?-(ethyne-1,2-diyl)diphenol (TOLECINE, also known as 4,4?-dihydroxytolan).

US Pat. No. 10,426,741

COLLAGEN AND ELASTIN STIMULATING COMPOUND AND TOPICAL COMPOSITIONS COMPRISING SUCH COMPOUND

Joventis, S.A., Strassen...

1. A compound having a structure according to Formula (I):

US Pat. No. 10,426,739

ADHESIVE PATCH ASSEMBLY WITH OVERLAY LINER AND SYSTEM AND METHOD FOR MAKING SAME

3M Innovative Properties ...

15. A method of making an article comprising an adhesive patch assembly, the method comprising the steps of:providing a patch having a periphery, the patch including a backing, a skin-contact adhesive coupled to the backing, a drug, and a skin penetration enhancer;
providing a release liner including a first major surface and a second major surface opposite the first major surface, at least the first major surface configured to present release characteristics relative to the skin-contact adhesive of the patch, the release liner having a first portion and a second portion, wherein each of the first portion and the second portion are dimensioned to accommodate the patch, and wherein the release characteristics of the first major surface of the first portion of the release liner are coextensive with the first major surface of the second portion of the release liner;
including a slit into the second portion of the release liner, wherein the second portion further comprises two separate sections separated by the slit;
positioning the patch on the release liner, such that patch is located on the second portion of the release liner and the first portion of the release liner is free of the patch, wherein when the patch is located between the first portion and the second portion of the release liner the first and second portions having said release characteristics extend a distance beyond the periphery of the patch;
folding the release liner about a hinge located between the first portion and the second portion to locate the patch between the first portion and the second portion of the release liner and to form an adhesive patch assembly; and
packaging the adhesive patch assembly in a separate and distinct hermetically-sealed pouch.

US Pat. No. 10,426,737

LIPIDS AND LIPID COMPOSITIONS FOR THE DELIVERY OF ACTIVE AGENTS

Novartis AG, Basel (CH)

1. A compound of formula (I) or a pharmaceutically acceptable salt thereof:
wherein:
n is 0, 1, 2, 3 or 4;
p is 0, 1, 2, 3, 4, 5, 6, 7 or 8;
L1 is —O— or a bond;
L2 is —OC(O)— or —C(O)O—;
R1 is

v is 0, 1, 2, 3 or 4;
w is 0, 1, 2 or 3;
R and R? are each, independently, hydrogen or C1-8 alkyl;
R2 is selected from: (i) C6-20 alkyl optionally substituted with a hydroxyl, and (ii) C15-19 alkenyl;
R3 is selected from: C4-22 alkyl, C12-22 alkenyl,

US Pat. No. 10,426,735

MODIFIED ALGINATES FOR ANTI-FIBROTIC MATERIALS AND APPLICATIONS

Massachusetts Institute o...

1. A multiply modified alginate polymer having a structure according to Formula IIIwhereinX is oxygen, sulfur, or NR4;
R1, R6, R7, R8, and R9 are, independently, hydrogen, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, alkoxy, substituted alkoxy, aroxy, substituted aroxy, alkylthio, substituted alkylthio, arylthio, substituted arylthio, carbonyl, substituted carbonyl, carboxyl, substituted carboxyl, amino, substituted amino, amido, substituted amido, sulfonyl, substituted sulfonyl, sulfonic acid, phosphoryl, substituted phosphoryl, phosphonyl, substituted phosphonyl, polyaryl, substituted polyaryl, C3-C20 cyclic, substituted C3-C20 cyclic, heterocyclic, substituted heterocyclic, amino acid, poly(ethylene glycol), peptide, or polypeptide group; wherein R1 and R6 are not hydrogen;whereinY1 and Y2 independently are hydrogen or —PO(OR5)2; or
Y2 is absent, and Y1, together with the two oxygen atoms to which Y1 and Y2 are attached form a cyclic structure as shown in Formula IV
whereinR2 and R3 are, independently, hydrogen, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, alkoxy, substituted alkoxy, aroxy, substituted aroxy, alkylthio, substituted alkylthio, arylthio, substituted arylthio, carbonyl, substituted carbonyl, carboxyl, substituted carboxyl, amino, substituted amino, amido, substituted amido, polyaryl, substituted polyaryl, C3-C20 cyclic, substituted C3-C20 cyclic, heterocyclic, substituted heterocyclic, amino acid, poly(ethylene glycol), peptide, or polypeptide group; or
R2 and R3, together with the carbon atom to which they are attached, form a 3- to 8-membered unsubstituted or substituted carbocyclic or heterocyclic ring; and
R4 and R5 are, independently, hydrogen, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, aryl, substituted aryl, heteroaryl, substituted heteroaryl, alkoxy, substituted alkoxy, aroxy, substituted aroxy, alkylthio, substituted alkylthio, arylthio, substituted arylthio, carbonyl, substituted carbonyl, carboxyl, substituted carboxyl, amino, substituted amino, amido, substituted amido, polyaryl, substituted polyaryl, C3-C20 cyclic, substituted C3-C20 cyclic, heterocyclic, substituted heterocyclic, amino acid, poly(ethylene glycol), peptide, or polypeptide group.

US Pat. No. 10,426,732

RAPIDLY DISINTEGRATING TABLET, AND METHOD FOR PRODUCING SAME

DAICEL CORPORATION, Osak...

1. An orally disintegrating tablet having a specific surface area of from 1.60 to 2.50 mm2/mg, a weight of from 10 to 30 mg, and a diameter of 4 mm or less, which comprises a disintegrative particulate composition containing crystalline cellulose in an amount of 1% to 40% by weight of a total weight of the composition, and has a disintegration time in water of 7 seconds or less and an oral disintegration time of 5 seconds or less.

US Pat. No. 10,426,730

OXIDIZED CELLULOSE MICROSPHERES

Covidien LP, Mansfield, ...

1. A microsphere comprising:a first biodegradable polymer encapsulating at least one additional microsphere, the at least one additional microsphere including a second biodegradable polymer and at least one bioactive agent, wherein the first biodegradable polymer and the second biodegradable polymer are different and one of the first biodegradable polymer or the second biodegradable polymer is oxidized cellulose.

US Pat. No. 10,426,727

FLUOROPOLYMER EMULSIONS WITH BRANCHED SEMIFLUORINATED BLOCK COPOLYMER OR PHOSPHOLIPID SURFACTANT FOR THE DELIVERY OF HYDROPHOBIC DRUGS

Wisconsin Alumni Research...

2. An emulsion for delivery of a therapeutic agent, said emulsion comprising:an aqueous solution;
semi-fluorinated block copolymers; wherein each of said semi-fluorinated block copolymers independently comprises a hydrophilic block, a hydrophobic block and a fluorophilic block; wherein each of said semi-fluorinated block copolymers has a branched structure wherein said hydrophilic block comprises a first branch, said hydrophobic block comprises a second branch and said fluorophilic block comprises a third branch; and
said therapeutic agent comprising a hydrophobic compound;
said emulsion comprising a continuous phase and a dispersed phase, wherein said continuous phase comprises said aqueous solution and said dispersed phase comprises said semi-fluorinated block copolymers and said therapeutic agent;
wherein each of said semi-fluorinated block copolymers independently has the formula (FX9A) or (FX9B):

wherein q is an integer selected from the range of 10 to 300, o is an integer selected from the range of 5 to 20, and p is an integer selected from the range of 3 to 15.

US Pat. No. 10,426,721

HIGH-GLOSS PHOTOCROSSLINKABLE COSMETIC COMPOSITION

1. A photocrosslinkable cosmetic composition, comprising in a physiologically acceptable medium:from 20% to 40% of at least one photocrosslinkable urethane dimethacrylate compound P1 according to formula (II):

wherein:
i is an integer ranging from 1 to 6,
j is an integer ranging from 1 to 6, and
R?1, R?2, R?3, and R?4, identical or different, represent a hydrogen atom or a C1-C10 alkyl chain,
from 40% to 65% of at least one photocrosslinkable urethane dimethacrylate compound P2 according to formula (IV):

wherein:
i is an integer ranging from 1 to 6,
j is an integer ranging from 1 to 6,
k is an integer ranging from 2 to 100,
l is an integer ranging from 1 to 10,
R1, R3, R3 and R4, identical or different, represent a hydrogen atom or a C1-C10 alkyl chain,
-A?- represents a linear or branched C1-C20 divalent alkylene group, or a C5-C20 divalent cycloalkylene radical,
from 0% to 10% of an acrylate copolymer film-forming polymer P3, and
from 1% to 10% of an ?-hydroxyketone photoinitiator, an acylphosphine oxide photoinitiator, or mixtures thereof,
wherein the percentages are expressed in relation to the total weight of said composition.

US Pat. No. 10,426,718

COMPOSITIONS AND METHODS FOR TREATING HAIR LOSS AND DELAYING AGING OF SKIN

Phyto Tech Corp., Rancho...

1. A method for treating hair loss or inducing hair growth in an individual who has telogen effluvium (TE) or alopecia areata comprising applying an effective amount of a dihydromyricetin compound to scalp of an individual, wherein the dihydromyricetin compound is of formula (I):
wherein each X is independently selected from hydrogen, alkyl, substituted alkyl, alkenyl, substituted alkenyl, halo, alkoxyl, heteroalkyl, substituted heteroalkyl, heteroalkenyl, or substituted heteroalkenyl;
wherein said dihydromyricetin compound is synthetic or is purified from a whole plant or a plant tissue of Hovenia dulcis; and
wherein X is independently selected from the group consisting of —CH3, —CH2CH3, —CH2CH2CH3, —CH(CH3)2, —CH2CH2CH2CH3, —CH2CH(CH3)2, —C(CH3)3, —CH2CH2CH2CH2CH3, —CH2C(CH3)2CH3, —C(CH3)2CH2CH3, —CH2CH2CH(CH3)2, —CH2CH2CH2CH2CH2CH3, —CH2C(CH3)2CH2CH3, —CH2CH2C(CH3)2CH3, —CH2CH2CH2CH(CH3)2, —CH2CH(CH2CH3)CH2CH3, —CH2CH2OCH3, —CH2CH2CH2OCH3, —CH2CH2CH2OCH2CH3, and —CH2CH2CH2CH2OCH2CH3.

US Pat. No. 10,426,717

GLYCOL ESTERS OF DICAFFEOYLQUINIC ACID AND USES THEREOF

PLANT ADVANCED TECHNOLOGI...

1. A compound of general formula (I)
wherein
R1 represents a radical chosen from the group consisting of the radicals of the following formulae (IIa) to (IIe), (III), (IVa) to (IVb) and (Va) to (Vd):

and wherein any two of the radicals R2, R3, R4 and R5 represent a caffeoyl group, the other two representing a hydrogen atom.

US Pat. No. 10,426,713

METHOD OF TREATING HAIR OR SKIN WITH A PERSONAL CARE COMPOSITION IN A FOAM FORM

The Procter and Gamble Co...

1. A method of treating hair or skin with a creamy foam, the method comprising:a. dispensing a personal care composition from a mechanical foam dispenser as a dosage of foam; wherein the dispenser does not contain a propellant or is substantially free of a propellant;
b. applying the dosage of foam to hair or skin;
c. rinsing the dosage of foam from hair or skin;
wherein the personal care composition comprises:
a viscosity of less than 60 cP;
a lather volume greater than 77 cm3;
from about 50% to about 90%, by weight of the composition, water;
from about 10% to about 50%, by weight of the composition, a surfactant system wherein the surfactant system comprises:
(i) from about 10% to about 30%, by weight of the composition, of an acyl glutamate;
(ii) from about 0.5% to about 7%, by weight of the composition, of a zwitterionic co-surfactant;
wherein the surfactant system is substantially free of sulfate-based surfactants.

US Pat. No. 10,426,711

DENTAL IMPLANT FRAMEWORK

1. A dental prosthesis and a plurality of implants and abutments to which the dental prosthesis mates, wherein the dental prosthesis comprises:a plurality of support posts, a plurality of crowns and a dental implant framework;
where the position of the plurality of support posts and the plurality of crowns is determined from digital data defining the appropriate tooth position for the dental prosthesis;
where the plurality of support posts and the plurality of crowns consist of predefined dimensions;
a plurality of fittings to mate with the corresponding plurality of implants and abutments when inserted in the patient's mouth;
where the position of the plurality of fittings has been determined through the use of digital data identifying the location of the plurality of implants and abutments in the patient's mouth;
a bridging structure or plurality of bridging structures attaching the support posts and fittings to one another; and
the combination of the bridging structure or plurality of bridging structures, plurality of support posts, and plurality of fittings providing the complete embodiment of the dental implant framework.

US Pat. No. 10,426,710

SYSTEM, METHOD AND APPARATUS FOR TEETHING DEVICE

Teetherpop, LLC, Austin,...

1. A teething device, comprising:a base having a handle on an end and a coupling on an opposite end, a y-axis extending through both the handle and the coupling, an x-axis and a z-axis extending perpendicular to the y-axis and to each other, and the base and coupling being formed from a first material having a first hardness;
a reservoir configured to contain a liquid therein, the reservoir having a coupling sealed to the base coupling and configured to provide a watertight seal, the reservoir has apertures that are the only apertures formed therein, the apertures consist of slits that are repeatably self-sealing, all of the slits are located only along a terminal distal end of the reservoir, each slit has a default position wherein each slit is configured to be resiliently biased to automatically return to be substantially closed to essentially prevent the liquid from flowing therethrough, and a flexed position wherein each slit is configured to be opened by squeezing to allow the liquid to flow therethrough;
the base further comprises a protrusion that extends into the reservoir, and the protrusion is spaced apart and free of contact with the reservoir;
the reservoir is formed from a second material having a second hardness that is softer than the first hardness, such that the reservoir is configured to be used as a teething device and capable of being frozen; and
the reservoir comprises a shape that is parabolic in a first plane of reference defined by the x-axis and the y-axis, and the reservoir has a second shape that is elongated and generally elliptical in a second plane of reference defined by the x-axis and the z-axis, such that an entirety of the reservoir is generally human tongue-shaped.

US Pat. No. 10,426,709

FEEDING SET AND ENTERAL FEEDING PUMP

KPR U.S., LLC, Mansfield...

1. A feeding set for use with a feeding pump to deliver nutritional liquid to a patient, the feeding set comprising:a container to store the nutritional liquid;
tubing in fluid communication with the container and being adapted for mounting on the feeding pump, the tubing providing a fluid pathway for delivering the nutritional liquid from the container to the patient; and
an identification member representative of the nutritional liquid in the container, the identification member configured to permit identification by the feeding pump of at least one characteristic of the nutritional liquid upon mounting of the identification member on the feeding pump, the at least one characteristic of the nutritional liquid comprising at least one of a nutritional content, a fluid flow property, and a brand or brand name of the nutritional liquid.

US Pat. No. 10,426,708

DEVICES AND METHODS FOR PERCUTANEOUS ENDOSCOPIC GASTRONOMY AND OTHER OSTOMY PROCEDURES

Fidmi Medical Ltd., Caes...

1. A PEG feeding device for conducting fluid through a stoma to a stomach comprising:a tube sized to bridge a channel between the stomach and an outer abdominal surface;
an internal bolster, sized to resist movement out of the stomach through the stoma and connected to said tube;
an external bolster, sized to resist movement into the stoma and connected to said tube;wherein said external bolster includes at least one elastically deflectable elastic element including an underside which extends from said tube in a radial direction and contacting said outer abdominal surface at a contacting point located at a distance from an external opening of said stoma and wherein said at least one elastically deflectable elastic element defines a void under said at least one elastically deflectable elastic element and between said external opening of said stoma and said contacting point with said outer abdominal surface.

US Pat. No. 10,426,707

TAMPER-PROOF PILL DISPENSING SYSTEM AND METHODS OF USE

1. A method for administering a pill dispensing system for managing the distribution of pills to a patient, the method comprising the steps of:implementing an at least one tamper-proof pill storage container that provides an at least one pill magazine positioned within a housing of the pill storage container and configured for storing and selectively dispensing a plurality of pills through a pill outlet provided by the housing;
implementing a patient application residing in memory on an at least one patient device under the control of the patient, the patient application in selective communication with the at least one pill storage container;
implementing an at least one monitoring device in selective communication with the patient application, the at least one monitoring device configured for assisting the patient application with monitoring an at least one vital of the patient;
obtaining from the patient at least one of a security code, via the patient application, and an at least one biometric marker associated with the patient, via an at least one biometric sensor;
registering, via the patient application, a prescription associated with the pills contained within the at least one pill magazine of the at least one pill storage container, said prescription including a dosage interval and a dosage quantity;
upon the patient application determining that a dosage of the pills is available for the patient, based on the associated dosage interval:
notifying the patient via at least one of an audible alert, a visual alert and a vibrational alert via the at least one patient device;
obtaining from the patient at least one of the security code and the at least one biometric marker;
upon the patient application authenticating at least one of the security code and the at least one biometric marker:
transmitting a signal, via the patient application, to the at least one pill storage container, instructing said pill storage container to distribute a quantity of pills equal to the associated dosage quantity; and
upon said pill storage container distributing the pills to the patient:
transmitting a signal, via said pill storage container, back to the patient application; and
scheduling, via the patient application, a future dosage of the pills based on the associated dosage interval; and
upon the patient application determining that the at least one monitored vital is abnormal:
notifying the patient via at least one of an audible alert, a visual alert and a vibrational alert via the at least one patient device;
upon the patient application failing to receive a response from the patient within a pre-defined period of time, automatically alerting, via the patient application, local emergency personnel; and
temporarily suspending future dosages of the pills until the patient application determines that said monitored vital has returned to normal.

US Pat. No. 10,426,706

MEDICINE DISPENSING DEVICE

YUYAMA MFG. CO., LTD., O...

1. A medicine dispensing device, comprising:a plurality of medicine cassettes configured to dispensably receive a medicine or a manual distribution medicine supply device that has a plurality of cells to which a medicine is distributed;
a printer configured to print a dosing information included in a prescription data on a packing paper;
a medicine packing mechanism to which the packing paper having the dosing information printed by the printer is supplied, wherein the medicine packing mechanism is configured to pack the medicine dispensed from the medicine cassette or the manual distribution medicine supply device one pack at a time based on the prescription data;
an image reader configured to read an identification portion from the medicine dispensed from the medicine cassette or the manual distribution medicine supply device before the medicine packing mechanism packs the medicine into the packing paper having the dosing information printed by the printer; and
a controller configured to perform an inspection process based on
the identification portion read by the image reader, and
a medicine information included in the prescription data,
wherein the medicine is dispensed from the medicine cassette or the manual distribution medicine supply device to the image reader, and
wherein the medicine, whose identification portion is read by the image reader, is discharged from the image reader to the medicine packing mechanism.

US Pat. No. 10,426,705

COLOSTRUM COLLECTION SYSTEM

LANSINOH LABORATORIES, IN...

1. An adapter system for facilitating collection of colostrum from a breast, the adapter system comprising:an adapter, comprising:
a body having a funnel connecting end for connecting to a breast shield of a breast pump system and a breast pump connecting end for connecting to a breast pump connector of the breast pump system;
a side port comprising a dispensing end, disposed between the funnel connecting end and the breast pump connecting end, configured for allowing the colostrum to pass out of the adapter;
a block inside the body, between the breast pump connecting end and the dispensing end, for directing the colostrum through the dispensing end, wherein the block comprises a flat wall oriented perpendicular to a cylindrical wall that forms the body of the adapter; and
an aperture in the block to allow suction force applied at the breast pump connecting end to generate suction at the funnel connecting end;
a removable reservoir comprising a wide end for removably attaching to the dispensing end of the adapter and a narrow end for attaching to a colostrum delivery device; and
a hand-expression funnel comprising a wide end for receiving colostrum and a narrow end for attaching to the colostrum delivery device.

US Pat. No. 10,426,704

PRE-DOSED APPLICATORS AND PACKAGING THEREFOR

Centrix, Inc., Shelton, ...

1. A package for containing and dosing pre-dosed applicators comprising:a container having a bottom and a top with a container depth from the bottom to the top of said container;
an absorbent pad placed adjacent the bottom, said absorbent pad having an initial dry compressed thickness and a subsequent expanded wet thickness;
a solution containing a material placed on the absorbent pad;
a plurality of applicators, each of said plurality of applicators having an applicator length and an absorbent end placed in the container, wherein the absorbent end is placed adjacent said absorbent pad;
wherein the applicator length combined with the initial dry compressed thickness of said absorbent pad is less than the container depth and the applicator length combined with the subsequent expanded wet thickness of said absorbent pad is greater than the container depth; and
a lid placed over the top of the container.

US Pat. No. 10,426,703

VIAL ADAPTERS

UNL Holdings LLC, New Yo...

1. A method of transferring fluid from a vial comprising a closure to a safety syringe, said method including connecting a vial adapter to the closure of the vial and to the safety syringe, fitting lateral arms of the vial adapter to the closure so that the vial adapter is in fluid communication with said safety syringe and inserting a conduit tip of the vial adapter into the safety syringe, the conduit tip inhibiting travel of a plunger of the safety syringe towards a distal end of the safety syringe.

US Pat. No. 10,426,702

MIXING AND/OR TRANSFERRING DEVICE

1. A device for mixing or transferring a first substance and a second substance that are present, respectively, in a first and a second receptacle, comprising:a first adapter having a circumferential wall, and being configured to accept the first receptacle, and along which extends, and which, at least in sections, surrounds a first cannula body, and a first hollow-cylindrical section connected to the first cannula body,
a second adapter having a circumferential wall, and being configured to accept the second receptacle, and along which extends, and which, at least in sections, coaxially surrounds, a second cannula body, and a second hollow-cylindrical section connected to the second cannula body,
wherein, in an assembled state, the first hollow-cylindrical section inter-engages with the second hollow-cylindrical section, and the first adapter and the second adapter are screwably and detachedly connected,
wherein each of the first and the second adapters comprises a hollow-cylindrical outer body with an exterior circumferential wall, and a partition wall extending perpendicularly to a longitudinal axis of the outer body,
wherein, when the first and second adapters are assembled together, a section, which has an inner thread, of the outer circumferential wall of one of the first and the second adapters surrounds a section, which has an external thread, of the outer circumferential wall of the other of the first and the second adapters, with inter-engaging threaded sections,
wherein the hollow-cylindrical outer body of at least one of the first and second adapters comprises an insert, having a circumferential wall, that accepts the first or the second receptacle, and
wherein the circumferential wall of the insert extends, at least in sections of the interior surface of the outer circumferential wall, spaced-apart from the interior surface of the outer circumferential wall.

US Pat. No. 10,426,701

SINGLE USE CONNECTORS

MEDINSTILL DEVELOPMENT LL...

1. A connector comprising:a first piece;
a piercing member attached to the first piece; and
a second piece, the piercing member being slidingly receivable within the second piece;
wherein the piercing member and the second piece are movable relative to each other between a first position where the second piece closes a flow port and a second position where the flow port is open;
the first piece further including a locking mechanism adapted to lockingly connect the first piece to a device when engaged therewith, thereby preventing subsequent disconnection and disengagement of the first piece and the device.

US Pat. No. 10,426,700

SYRINGE ACCESSORY FOR TRANSFER OF AIR SENSITIVE MATERIALS

International Business Ma...

1. An apparatus for transferring fluid contained in a syringe, comprising:an airlock component having a cylindrical body, the cylindrical body having a first end, a second end, and a hollow tube disposed between the first end and the second end, wherein the hollow tube has an interior surface and an exterior surface;
an annular opening at the first end of the cylindrical body;
a gas inlet aperture from the exterior surface of the hollow tube to the interior surface of hollow tube;
a gas outlet aperture from the interior surface of the hollow tube to the exterior surface of the hollow tube;
an inwardly-facing airtight material coupled to the interior surface of the hollow tube; and
a septum coupled to the second end of the cylindrical body.

US Pat. No. 10,426,698

PILL CONTAINER WITH CAP

Breeden Brothers, LLC, N...

1. A pill container comprisingan outer shell having a flat bottom section and an angled corner section, the angled corner section having an opening for dispensing pills, wherein the outer shell includes a first shell section and a second shell section that snap together to form the outer shell;
a bottle disposed within the outer shell, wherein the first shell section and the second shell section snap together around the bottle to enclose all but a spout of the bottle;
a constriction within the bottle configured to reduce flow of the pills out from the pill container, and
a cap formed in substantially triangular shape, the cap configured to screw onto the bottle and seal the opening of the outer shell, wherein the cap includes a raised section having a notch, the notch configured to pass over and engage with a raised insert protruding from the bottle as the cap is turned.

US Pat. No. 10,426,697

COMPACT ELECTRO-MECHANICAL CHEST COMPRESSION DRIVE

Koninklijke Philips N.V.,...

1. A cardio-pulmonary compression device, comprising:a motor having a rotating portion;
a ball nut mounted on the rotating portion and configured to rotate with the rotating portion;
a ball screw being received in the ball nut such that rotation on the ball nut advances and/or retracts the ball screw in accordance with a direction of the motor;
a pad assembly coupled to an end portion of the ball screw such that longitudinal motion of the ball screw imparts a compression cycle to a patient.

US Pat. No. 10,426,696

DEFIBRILLATOR DISPLAY INCLUDING CPR DEPTH INFORMATION

ZOLL Medical Corporation,...

1. An external defibrillator system for treatment of a patient, comprising:one or more compression sensors for measuring chest compression information and producing chest compression signals based on the measured chest compression information;
one or more physiological sensors for measuring physiological information and producing physiological signals based on the measured physiological information; and
at least one processor configured to:
receive and process the chest compression signals and the physiological signals,
determine values for chest compression depth and/or chest compression rate based on the received chest compression signals,
determine a trend of at least one physiological parameter over a period comprising multiple chest compressions based on the received physiological signals,
adjust a target chest compression depth and/or target chest compression rate based on the determined trend of the at least one physiological parameter,
compare the determined values for chest compression depth and/or chest compression rate to the adjusted target compression depth and/or the adjusted target compression rate, and
provide feedback about the quality of chest compressions performed on the patient based on the comparison between the determined values for chest compression depth and/or chest compression rate to the adjusted target compression depth and/or the adjusted compression rate.

US Pat. No. 10,426,695

SYSTEM AND METHOD FOR CARDIOPULMONARY RESUSCITATION

COVIDIEN LP, Mansfield, ...

1. A method for determining an efficacy of cardiopulmonary resuscitation (CPR), the method comprising, using a processor configured to determine the efficacy of CPR, wherein the processor is associated with a patient monitor, an oximetry sensor, and an electrocardiogram (ECG) sensor, and wherein determining the efficacy of CPR comprises:receiving, at the processor, a plethysmography signal from the oximetry sensor;
receiving, at the processor, an ECG signal from the ECG sensor;
determining a first indicator related to the efficacy of CPR based on the plethysmography signal, using the processor;
determining a second indicator related to the efficacy of CPR based on the ECG signal, using the processor;
combining the first indicator and the second indicator to determine a combination metric indicative of the efficacy of CPR, using the processor; and
adjusting parameters controlling one or both of a rate or depth of compressions applied by a CPR device based on the combination metric.

US Pat. No. 10,426,694

METHODS AND APPARATUS FOR ADJUSTING BLOOD CIRCULATION

AVACORE TECHNOLOGIES, INC...

1. A method of preventing and/or reducing a risk of deep vein thrombosis (DVT) in an appendage of a mammal, comprising:cyclically varying pressure within an internal region of a flexible body of a device, wherein
one or more first flexible walls of the flexible body at least partially enclose the internal region, and
the flexible body defines an outermost surface of a portion of the device, and the portion of the device is configured to be disposed over a portion of the appendage of the mammal when the portion of the appendage is disposed within the internal region through an opening that is formed within flexible body, and
wherein the method of cyclically varying pressure within the internal region comprises:
(a) adjusting the pressure within the internal region to a first pressure level that is below atmospheric pressure, wherein the adjusted pressure causes the one or more first flexible walls to collapse against the portion of the appendage that is disposed within the internal region, and the flexible body is configured to substantially conform to the shape of the portion of the appendage when the first pressure level is achieved within the internal region; and
(b) adjusting the pressure within the internal region to a second pressure level; and
(c) repeating (a) and (b) at least one more time before removing the appendage from the internal region.

US Pat. No. 10,426,693

MASSAGE MACHINE

DAITO ELECTRIC MACHINE IN...

1. A massage machine comprising:a pair of left and right massage members provided so as to hold a treatment region;
a rotating shaft provided so as to laterally penetrate the left and right massage members;
a drive unit for rotationally driving the rotating shaft; and
a conversion part converting a rotating force of the rotating shaft to a massage operation caused by the massage members,
a horizontal movement mechanism causing at least one of the pair of left and right massage members to move in a horizontal direction along the rotating shaft by rotating the rotating shaft to thereby make a variable interval between the pair of left and right massage members at two positions on one end side or the other end side of the rotating shaft by rotating the rotating shaft,
said horizontal movement mechanism includes a screw thread part rotationally fixed to the rotating shaft, and a movable and rotational first tilt rotor having a helical internal tooth formed on an inner circumferential surface, said helical internal tooth being in operative engagement with the screw thread part,
said movable and rotational first tilt rotor configured to integrally rotate with the rotating shaft upon reaching one end or the other end of the screw thread part, and
said movable and rotational first tilt rotor is configured so as to reach one end of the screw thread part when the rotating shaft is rotated in one direction by the drive unit and is configured so as to reach the other end of the screw thread part when the rotating shaft is rotated in the other direction.

US Pat. No. 10,426,692

SKIN TREATMENT APPARATUS AND METHOD FOR THE SAME

KONINKLIJKE PHILIPS N.V.,...

14. A method of treating a skin surface, comprising:providing a skin treatment apparatus including:
a hand-held base body;
a rotor head, movably connected to the hand-held base body such that it is rotatable relative to the hand-held base body around a rotation axis, and including at least one skin contacting element;
moving the hand-held base body relative to the skin surface, and generating a movement signal that reflects a path of relative movement between the hand-held base body and the skin surface; and
rotatably driving the rotor head in dependence of the movement signal, while the at least one skin contacting element touches the skin surface.

US Pat. No. 10,426,691

PORTABLE THERAPEUTIC APPARATUS

MyoROM Sports Med II, LLC...

9. A method for applying a force to a desired area of a body, the method comprising:setting a resistance force on a resistance element disposed in a second slot, the resistance element applying the resistance force to a protrusion extending from an opening in a handle;
applying up to an initial force to the handle while the protrusion rests against a desired area of the body;
applying a transitional force less than the initial force while the protrusion translates in a first slot after the initial force overcomes the resistance force; and
applying a final force when the protrusion impacts a termination of the first slot, wherein the final force is greater than one or both of the transitional force and the initial force.

US Pat. No. 10,426,690

FOLDABLE WALKER

1. A foldable walker comprising:a front frame including two sleeve tubes which are disposed opposite to each other in a left-and-right direction, and each of which extends along an axis in an upright direction, each of said sleeve tubes having an upwardly facing retaining portion which surrounds the axis and which has an unfolding recessed region and a folding recessed region that are angularly displaced from each other about the axis;
two side frame units, each including a front rod segment which is coaxially and rotatably mounted to a respective one of said sleeve tubes, a rear rod segment which is opposite to said front rod segment so as to be turnable about the axis relative to said front frame between a folded position, where said rear rod segment is close to said front frame, and an unfolded position, where said rear rod segment is remote from said front frame to be disposed opposite to said front rod segment in a front-and-rear direction, and an adaptor, said adaptor having an upright tubular wall which is coaxially connected to said front rod segment and defines therein an accommodating space that has an upper opening; and
two folding operating units, each disposed in said accommodating space and including a locking pin, a connecting member and a lock releasing member, said locking pin having a retained end which is disposed upwardly of said upwardly facing retaining portion, and extending radially and inwardly from said retained end toward the axis, said locking pin being movable along the axis between a locking position, where said retained end is engaged with a selected one of said unfolding and folding recessed regions to hold said respective side frame unit in a corresponding one of the unfolding position and the folding position, and an unlocking position, where said retained end is disengaged from said upwardly facing retaining portion to permit turning of said respective side frame unit relative to said front frame, said connecting member having a lower end which is securely connected to said locking pin and extending in the upright direction from said lower end to terminate at an upper end which is disposed proximate to said upper opening, said lock releasing member being movably mounted on said adaptor and having an operating portion which projects from said upper opening to be manually operable, and a driving portion which is connected with said upper end of said connecting member for moving said locking pin from the locking position to the unlocking position.

US Pat. No. 10,426,689

BIOMECHANICAL AND ERGONOMICAL ADJUSTABLE CRUTCH

Mobi Acquisition Company,...

1. A rotatable shock absorber assembly for a crutch having a support leg having a hollow upper portion extending along a generally vertical elongate axis, and a saddle adapted for arrangement within an armpit of a user, the rotatable shock absorber assembly comprising:a guide pin, removably fixable within the upper portion of the support leg, and extending along an axis orthogonal to the elongate axis;
a piston including—
a flange arranged proximate the saddle, including a top surface having two or more arcuate rotation grooves defined therein,
a main body, slideably arrangable within the upper portion of the support leg and defining an elongate slot enabling the guide pin to be inserted therethrough, such that the piston can translate along the elongate axis relative to the guide pin;
a joint, operably coupling the piston to the saddle, the joint including two or more rotation pins, each slidably insertable within a respective one of the two or more arcuate rotation grooves such that the joint can rotate about the elongate axis relative to the piston; and
a biasing mechanism configured to urge the piston along the elongate axis toward the armpit of the user;
whereby the saddle can be held stable in the armpit of the user and the support leg can rotate about, and translate along the elongate axis during use of the crutch by the user.

US Pat. No. 10,426,688

SYSTEMS AND METHODS FOR TRANSFERRING EXOSKELETON TRAJECTORY SEQUENCES

Ekso Bionics, Inc., Rich...

1. A method for transferring an exoskeleton trajectory sequence using at least one server remote from a first device including a controller, the method comprising:transferring, with the at least one server, the exoskeleton trajectory sequence to the first device where the exoskeleton trajectory sequence is validated, wherein validating the exoskeleton trajectory sequence includes performing a safety check in which a determination is made with the controller as to whether the exoskeleton trajectory sequence is safe for use with exoskeletons, the first device includes a first exoskeleton, the safety check includes performing a physical test of the exoskeleton trajectory sequence using the first exoskeleton, performing the physical test includes causing the first exoskeleton to move and receiving data from a sensor of the first exoskeleton, and causing the first exoskeleton to move includes causing the first exoskeleton to perform the exoskeleton trajectory sequence; and
receiving, from the first device, the exoskeleton trajectory sequence or confirmation that the exoskeleton trajectory sequence is valid with the at least one server, wherein the exoskeleton trajectory sequence includes prescribed positions of joints of an exoskeleton over time or a force profile of actuators of the exoskeleton.

US Pat. No. 10,426,687

MECHANICAL LINKAGE

Moog BV, Nieuw-Vennep (N...

1. A rehabilitation apparatus comprising:a force provider;
a recipient object, wherein the recipient object is a body part support; and
a linkage configured to transfer a force from the force provider to the recipient object, the linkage comprising a first link and a second link;
the first link having a first rotational joint defining a first link axis, and a second rotational joint defining a second link axis, the first and second link axes being at a first link angle to each other, which first link is pivotably attached to the recipient object for rotation about the first axis; and,
the second link having a third rotational joint defining a third link axis, and a fourth rotational joint defining a fourth link axis, the third and fourth link axes being at a second link angle to each other, the second link being pivotably attached to the first link such that the second and third link axes coincide, the second link being pivotably mounted at the fourth link axis to transfer a force from the force provider,
in which the first, second, third and fourth axes intersect at a predetermined point such that the recipient object can rotate about the predetermined point by articulation of the linkage;
in which the first and second link angles are each less than 45 degrees; and
in which the body part support is a foot support, and the force provider is configured to exert the force in a fore-aft direction of a subject's foot in use.

US Pat. No. 10,426,686

DRIVING MODULE AND MOTION ASSISTANCE APPARATUS INCLUDING THE SAME

Samsung Electronics Co., ...

1. A driving device comprising:a driving source configured to rotate in a first direction and a second direction, the second direction being opposite the first direction;
a first wire and a second wire connected to the driving source;
a first joint connected to the first wire and not the second wire, the first joint corresponding to one joint of a limb of a user, the first joint configured to rotate in a moving direction of the first wire; and
a second joint connected to the second wire and not the first wire, the second joint corresponding to another joint of the limb of the user, the second joint configured to rotate in the moving direction of the second wire.

US Pat. No. 10,426,685

MOBILE PATIENT BED

OPTIMEDICA CORPORATION, ...

1. A mobile patient bed for moving a patient between at least two locations during a medical procedure, the mobile patient bed comprising:at least one user control configured receive user commands;
a communication device configured to selectively couple the mobile patient bed to at least one medical system;
at least one processor configured to:
in response to the mobile patient bed being coupled to the at least one medical system, receive a medical system command via the communication device and process the medical system command, and refrain from processing user commands received from the at least one user control; and
in response to the mobile patient bed not being coupled to the at least one medical system, receive and process a user command received from the at least one user control;
a seat; and
a plurality of motors configured to move the seat in a plurality of degrees of freedom, wherein the moving of the seat is performed in response to the processed medical system command or the processed user command.

US Pat. No. 10,426,684

PERSON SUPPORT APPARATUSES INCLUDING PERSON REPOSITIONING ASSEMBLIES

Allen Medical Systems, In...

1. A person support apparatus comprising:a base frame;
a primary support frame supported on the base frame, wherein the primary support frame extends in a longitudinal direction;
a support deck coupled to the primary support frame, the support deck comprising:
an upper segment positioned at a head end of the person support apparatus;
a leg segment positioned at a foot end of the person support apparatus; and
a torso segment positioned between the upper segment and the leg segment in the longitudinal direction, wherein:
the torso segment comprises a first portion and a second portion oriented transverse to the first portion; and
the second portion is selectively coupled to and removable from the first portion;
a first rocker member coupled to the first portion of the torso segment; and
a second rocker member coupled to the second portion of the torso segment, wherein:
the first rocker member and the second rocker member are aligned with one another in the longitudinal direction; and
the first portion and the second portion of the torso segment rotate with respect to the primary support frame about a common axis that extends in the longitudinal direction.

US Pat. No. 10,426,683

PATIENT REPOSITIONING SYSTEM FOR BARIATRIC BED

Hillenbrand Management Co...

1. A patient repositioning system comprising:a mattress having a head end and a foot end and an upper surface;
a sheet residing on the upper surface;
a drive mechanism operatively coupled to the sheet and adapted to pull the sheet toward the head end, thereby to reposition a patient supported on the mattress;
a housing holding the drive mechanism; and
the mattress further comprising a body portion and at least one side bolster operatively coupled along one longitudinal side of the body portion, thereby to widen the upper surface of the mattress so as to accommodate bariatric dimensions,
wherein the mattress body portion comprises at least one row of one or more retainers substantially covered by the operatively coupled side bolster, and
wherein the operatively coupled side bolster comprises voids located on a vertically oriented inner surface thereof which abuts against the adjacently located mattress body portion, the voids corresponding to a like number of retainers on the abutting surface of the mattress body portion, whereby the voids facilitate proper positioning and alignment of the side bolster.

US Pat. No. 10,426,681

TOPPER FOR A PATIENT SURFACE WITH FLEXIBLE FABRIC SLEEVES

Hill-Rom Services, Inc., ...

1. A patient support apparatus comprisinga cushion including a plurality of inflatable bladders adapted to support a patient,
a topper arranged to extend over a top side of the cushion and configured to conduct air along an actively-cooled region of the top side of the cushion from a flexible fabric sleeve arranged to extend in a vertical direction between adjacent individual ones of the plurality of inflatable air bladders included in the cushion at a location between a left and a right side of the cushion, the flexible fabric sleeve being in pneumatic communication with the actively-cooled region to provide at least a portion of a fluid distributor for carrying air or other gasses to the actively cooled region, and
a lower ticking and an upper ticking that cooperate to encase the cushion and the topper.

US Pat. No. 10,426,680

AIR BLADDER CONTROL OF MATTRESS/FRAME WIDTH EXPANSION

Hill-Rom Services, Inc., ...

1. A patient support system for supporting a patient, comprising:a deck and extension chambers, the deck having a main deck portion and side deck portions connected to the main deck portion at opposing longitudinal sides of the main deck portion,
a controller including a processor and a memory device, the memory device including instructions that, when executed by the processor, send a command signal indicating a requirement for transfer of fluid to or from the extension chambers, and
a fluid supply device configured to receive the command signal and move fluid into or out of the extension chambers based on the command signal,
wherein the extension chambers expand or contract based on the flow to or from the fluid supply device to drive the side deck portions between a retracted position and an extended position, and wherein the extension chambers support the patient.

US Pat. No. 10,426,679

SYSTEMS FOR PATIENT SUPPORT SURFACE ORIENTATION AND DISPLACEMENT

UMANO MEDICAL INC., (CA)...

1. A backrest pivoting system for a bed, the bed having a frame and a backrest pivotably connected to the frame, the backrest pivoting system comprising:an actuator having a first actuator portion connected to an actuator pivot pin movably mounted to the frame and a second actuator portion connected to the backrest for pivoting the backrest relative to the frame, the actuator further having a transmission adapted for operatively coupling the second actuator portion to the first actuator portion;
a release operatively connected to the transmission, the release being movable between a locked position in which the first actuator portion is coupled to the second actuator portion and an unlocked position in which the second actuator portion is decoupled from the first actuator portion to allow free pivoting of the backrest towards the frame;
a resilient member between the frame and the actuator pivot pin, the resilient member being compressible and configured such that the actuator pivot pin moves towards the frame when the release is moved from the unlocked position into the locked position as the backrest pivots towards the frame.

US Pat. No. 10,426,678

CHILD SUPPORT STRUCTURE

14. A support member for a disabled child, comprising:a frame configured to rest upon the ground and having a base member, an upper rim portion, and a support member interposed between the rim portion and the base member configured to support the rim portion, wherein the frame defines a central space configured to receive a child in a standing position;
a harness coupled to the frame and supported above the ground, the harness having a seat configured to support the weight of the child, and further comprising a leg support configured to be securely coupled about a leg of the child and restrain the leg within the central space;
wherein the harness is configured to be selectively opened to receive a leg of the child, and then secured in a closed position about the leg;
wherein the harness comprises at least one first strap selectively extending between a front of the seat at one end and the frame at the opposing end; and
further comprising a second strap extending between a rear portion of the seat and the frame.

US Pat. No. 10,426,677

RECLINING TRANSPORT CHAIRS

The UAB Research Foundati...

1. A wheelchair configured to recline and incline forward, said wheelchair comprising:(a) a base frame having a first pivot axis;
(b) at least two wheels rotationally mounted to said base frame;
(c) a seat assembly and a footrest assembly configured to pivot about said first pivot axis from a first seated position to an inclined seated position; and
(d) a leg rest assembly pivotally coupled to said base frame and configured to pivot about a second pivot axis to elevate in unison with the seat assembly when said seat assembly reclines but independent of said footrest assembly.

US Pat. No. 10,426,676

WHEELCHAIR CLIMB SYSTEMS AND ASSEMBLIES

1. A stair climbing system for a wheelchair having a pair of rear larger drive wheels, a pair of small caster wheels, and a static hand grip for a caregiver being located at a back region behind an occupant seat; the system comprises:(1) a rollover- climb system comprising a rear rollover-climb lever, a rollover lever crank and a rollover mechanism housed within a gearbox, wherein the rear rollover-climb lever is mechanically linked to the gearbox to permit the caregiver located at the back-end region of the wheelchair to apply a downwards forceful thrust extending downward to a stair step pivot point, and sufficient to shift the lever from an upward-position to a downward-position; and
(2) wherein the rollover climb system is configured to translate the downwards forceful thrust to a rollover rotation torque around the stair step pivot point to enable the wheelchair to climb over the stair step.

US Pat. No. 10,426,675

ANTI-COLLISION SYSTEM FOR PERSONAL MOBILITY SCOOTERS

1. A system for reducing encounters between a mobility scooter and objects or ledges, wherein the mobility scooter includes a controller that is configured to receive movement signals from electronic components of the mobility scooter via a first multi-pin connector, the controller configured to control movement based on the movement signals, the system comprising:a second multi-pin connector configured to couple with the first multi-pin connector and intercept a first movement signal transmitted from a first electronic component of the mobility scooter to the controller of the mobility scooter, the first movement signal indicating (i) a movement variable and (ii) a direction; and
an anti-collision circuitry configured to communicatively couple with (1) the second multi-pin connector, and (2) the controller via the first multi-pin connector or the second multi-pin connector:
receive the first movement signal from the second multi-pin connector,
receive, via the second multi-pin connector, proximity data from one or more proximity sensors,
perform a determination as to whether the proximity data indicates that the mobility scooter is within a proximity threshold, wherein the proximity threshold corresponds to the movement variable,
in response to determining the received proximity data indicates the mobility scooter is within the proximity threshold, overriding the first movement signal and providing one or more control signals to the controller via the second multi-pin connector and the first multi-pin connector, wherein the one or more control signals are relayed to at least a throttle, a motor or a brake of the mobility scooter; and
in response to determining the received proximity data indicates the mobility scooter is not within the proximity threshold, allowing the first movement signal to pass to the controller.

US Pat. No. 10,426,674

SECURING SYSTEM FOR WHEELCHAIRS IN A VEHICLES AND A METHOD FOR UNLOCKING AND LOCKING A SECURING SYSTEM FOR WHEELCHAIRS IN VEHICLES

CARBOUW B.V., (NL)

1. A securing system for wheelchairs in vehicles, comprising a rigid bottom frame provided with;one or more fixation elements which are connected to the bottom frame and suitable for fixing a wheelchair relative to the bottom frame,
wherein the one or more fixation elements comprise a coupling elements configured for coupling to a wheelchair, the coupling elements are connected with cables to one or more retractors, and the one or more retractors in an unlocked mode exert a retracting pulling force on the coupling elements while the cables can be pulled out, and in a locked mode lock the cables so that the cables cannot be pulled out, and wherein the retractors are fixedly connected to the bottom frame and are placed adjacently of each other, and
a central securing control for simultaneous operation of the retractors, wherein the central securing control is movable within a guide contour provided in the bottom frame, and the central securing control comprises an actuator which is disposed in guidable manner within the guide contour, while the actuator is connected rotatably to a control plate for simultaneous operation of the retractors.

US Pat. No. 10,426,673

PLATFORM ENTRANCE GATE SAFETY BARRIER FOR A MOBILITY VEHICLE LIFT

The Braun Corporation, W...

16. A lift platform assembly configured to be coupled to a floor and transition a lift platform between a stowed position and a ground level position, comprising:one or more arms coupling the lift platform to the floor;
a gate mount pivotally coupled to the lift platform along a first platform side, the gate mount defining both a mount pivot axis and a gate axis therethrough;
a retention gate pivotally coupled to the gate mount;
a roll stop plate pivotally coupled to the lift platform at an outboard end and extending between the first platform side and a second platform side; and
a latch assembly coupled to the lift platform at the second platform side and configured to selectively couple the retention gate to the second platform side;
wherein when the latch assembly is not coupled to the retention gate and the lift platform is in the ground level position, the retention gate is pivotable about the gate axis away from the second platform side.

US Pat. No. 10,426,672

MOISTURE DETECTION AND NOTIFICATION SYSTEM

1. A moisture or fluid detection system, comprising:a sensor pad capable of detecting moisture or fluid that is not in contact with the sensor pad, the sensor pad comprising:
a first substrate;
a plurality of conductive leads disposed on the first substrate and defining at least one zone, each zone defined by an area in which one conductive lead is interdigitated with another conductive lead; and
a coupling unit coupled to at least two conductive leads; and
a processing unit configured to read impedances of the sensor pad, the processing unit comprising a controller and a communication interface, wherein the number of zones is equal to or greater than the number of conductive leads.

US Pat. No. 10,426,671

METHOD FOR MANUFACTURING A NONWOVEN HAVING IMPROVED SOFTNESS SIGNALS

PFNonwovens LLC, Hazleto...

1. A method of manufacturing a nonwoven web comprising the steps of:forming a nonwoven web substantially comprised of continuous fibers;
applying a bonding pattern to said nonwoven web using a smooth roll and a calender roll wherein said bonding pattern comprises a pattern having unbonded areas; and
subjecting the side of said nonwoven web contacted by said smooth roll to a hydroengorgement treatment at a pressure of between 25 and 75 bars and a total energy of about 0.01-0.04 kwhr/kg.,
wherein said continuous fibers are comprised of between 97% and 98.5% by weight of an olefin resin comprising substantially of polypropylene and between 1.5% and 3% by weight of a whitener.