US Pat. No. 10,456,613

ADJUSTABLE STRETCHING APPARATUS

1. A stretching apparatus, comprising:a vertical post comprising a bottom end supported by a base;
said vertical post comprising a plurality of holes disposed therethrough, said plurality of holes being disposed along said vertical post in a vertically spaced relation to one another;
at least one horizontal support bar selectively positionable at least partially through one of said plurality of holes at a time, said at least one horizontal support bar comprising a proximal end and a distal end;
a stopper disposed at said proximal end of said at least one horizontal support bar, said stopper configured to restrict movement of said at least one horizontal support bar from being disposed completely through said each of said plurality of holes;
a plurality of fixed support bars respectively extending outward from said vertical post, each of said plurality of fixed support bars being fixedly attached to said vertical post at a position below at least two of the plurality of holes so as to allow a user to lean on one of said plurality of fixed support bars with an arm of the user extended downward while an ankle of the user rests on said at least one horizontal support bar; and
wherein said distal end of said at least one horizontal support bar is selectively disposable through one of said plurality of holes disposed along said vertical post, and said at least one horizontal support bar is positionable through said one of said plurality of holes until said stopper restricts further movement of said at least one horizontal support bar therethrough.

US Pat. No. 10,456,604

GARMENT SYSTEM INCLUDING AT LEAST ONE THERAPEUTIC STIMULATION DELIVERY DEVICE AND RELATED METHODS

ELWHA LLC, Bellevue, WA ...

1. A system for delivering therapeutic stimulation to a subject, the system comprising:at least one flexible compression garment configured to be worn on at least one body part of the subject, the at least one flexible compression garment defining an interior space configured to receive the at least one body part;
one or more sensors positioned and configured to sense at least one characteristic of the at least one body part that is related to at least one of movement or a physiological state of the at least one body part, the one or more sensors further configured to output one or more sensing signals indicative of the at least one characteristic;
an array of therapeutic stimulation delivery devices (“TSDDs”) positioned and configured to dynamically apply therapeutic radiation to the at least one body part;
a controller operably coupled to the one or more sensors to receive the one or more sensing signals therefrom and to the array of TSDDs, the controller including control electrical circuitry configured to direct the array of TSDDs to dynamically apply the therapeutic radiation to a region of the at least one body part responsive to one or more sensing signals.

US Pat. No. 10,456,597

MULTILEAF COLLIMATOR AND RADIATION TREATMENT DEVICE

Hitachi, Ltd., Tokyo (JP...

1. A multileaf collimator for regulating a range irradiated with a radiation beam, comprising:a plurality of leaves arranged along a thickness direction, wherein
each of the plurality of leaves comprising;
a protruded portion protrudingly formed on a first side surface in a plate thickness direction of the leaf,
a depressed portion formed in a second side surface in the plate thickness direction of the leaf, and configured to receive insertion of the protruded portion formed on another one of the plurality of leaves,
a first curved surface formed between the first side surface of the leaf and a lateral surface of the protruded portion, and
a second curved surface formed between the second side surface of the leaf and a lateral surface of the depressed portion.

US Pat. No. 10,456,589

SYSTEM AND METHOD FOR PROVIDING HEAD-RELATED MEDICAL AND MENTAL HEALTH CONDITIONS

7. A device, comprising:an eyewear adapted to be worn on a face of a human user, the eyewear comprising:
a frame defining two lens portions, wherein each lens portion engages a periphery of an optical lens, wherein each optical lens is a transitional optical lens; and
two frame arms, each frame arm extending from a respective opposing end of the frame;
an electromagnetic generator system provided by the eyewear;
a stimulation arm electrically connected to the electromagnetic generator system, wherein the stimulation arm is pivotally connected to one of the two frame arms, the stimulation arm configured to be moveable between a storage condition and an operative condition, the stimulation arm is configured to extend upwardly of said frame arm to position the stimulation arm adjacent a temple of the human user while the device is worn by the human user;
a stimulation plate electrically connected to the electromagnetic generator system, wherein the stimulation plate is disposed between the two lens portions;
a plurality of light sources disposed along a lateral edge of at least one of the two lens portion, wherein the plurality of light sources provides dichroic light directed generally parallel to the respective optical lens; and
at least one switch electrically connected to the plurality of light sources and the electromagnetic generator system for selectively operating the dichroic light and a magnetic pulsing emitted therefrom, respectively.

US Pat. No. 10,456,581

SINGLE PASS CORONARY VENOUS LEAD FOR MULTIPLE CHAMBER SENSE AND PACE

Cardiac Pacemakers, Inc, ...

1. A method of pacing a patient's heart using an implantable lead including a plurality of proximal electrodes and a plurality of distal electrodes, the implantable lead having a proximal region including at least one of the plurality of proximal electrodes positioned in a coronary sinus or great cardiac vein of the patient's heart and a distal region positioned in a coronary vein of the patient's heart such that at least one of the plurality of distal electrodes is situated proximate an intraventricular septum of the patient's heart, the method comprising:sensing an atrial and a ventricular signal of the patient's heart via at least one of the proximal electrodes and at least one of the distal electrodes, respectively;
determining a pacing threshold associated with each of the plurality of distal electrodes;
selecting at least one of the plurality of distal electrodes that have associated therewith right and left ventricular pacing thresholds; and
delivering a pacing signal to the patient's heart via the selected at least one distal electrode, the transmitted pacing signal causing a desired contraction of both the right ventricle and the left ventricle.

US Pat. No. 10,456,578

UTILIZATION OF AN EXTENDED INTER-PULSE INTERVAL IN A MODIFIED CONTINUOUS INTERLEAVED STIMULATION STRATEGY

Advanced Bionics AG, Sta...

1. A sound processor included in a cochlear implant system associated with a patient, the sound processor comprising:a processing facility that
receives an audio signal presented to the patient, and
divides the audio signal into a plurality of analysis channels each containing a frequency domain signal representative of a distinct frequency portion of the audio signal, the plurality of analysis channels including a first analysis channel corresponding to a first electrode and that contains a first frequency domain signal; and
a control facility communicatively coupled to the processing facility and that represents the first frequency domain signal to the patient by
directing a cochlear implant included in the cochlear implant system to apply, during a first stimulation frame, a first monophasic stimulation pulse representative of a first temporal portion of the first frequency domain signal that corresponds to the first stimulation frame, the first monophasic stimulation pulse having a first polarity; and
directing the cochlear implant to apply, during a second stimulation frame that is temporally subsequent to the first stimulation frame, a second monophasic stimulation pulse representative of a second temporal portion of the first frequency domain signal that corresponds to the second stimulation frame, the second monophasic stimulation pulse configured to at least partially charge balance the first monophasic stimulation pulse and having a second polarity opposite the first polarity,
wherein:
the first electrode is included in an array of electrodes implanted within the patient;
the first stimulation frame corresponds to a first time period during which the first monophasic stimulation pulse is applied by the cochlear implant to the first electrode and a first set of monophasic stimulation pulses are sequentially applied by the cochlear implant to each remaining electrode included in the array of electrodes; and
each monophasic stimulation pulse in the first stimulation frame has an opposite polarity to each directly adjacent monophasic stimulation pulse in the first stimulation frame.

US Pat. No. 10,456,577

AUDITORY PROSTHESIS SYSTEM INCLUDING SOUND PROCESSOR AND WIRELESS MODULE FOR COMMUNICATION WITH AN EXTERNAL COMPUTING DEVICE

Advanced Bionics AG, Sta...

1. A system comprising:an external computing device that:
establishes a wireless communication link with a sound processor apparatus associated with a patient, wherein the sound processor apparatus is configured to be located external to the patient and control a cochlear implant configured to be implanted within the patient,
receives a first dataset from the sound processor apparatus by way of the wireless communication link, the first dataset comprising data representative of one or more sound processing programs loaded onto the sound processor apparatus,
obtains a second dataset from a source other than the sound processor apparatus, the second dataset comprising data associated with an environment of the external computing device,
identifies, based on the first and second datasets, a sound processing program not already loaded onto the sound processor apparatus, and
transmits, by way of the wireless communication link, data representative of the sound processing program to the sound processor apparatus.

US Pat. No. 10,456,573

MEDICAL CUFF EMPLOYING ELECTRICAL STIMULATION TO CONTROL BLOOD FLOW

Feinstein Patents, LLC, ...

1. A device for controlling blood flow, comprising:a cuff configured to mount to an extremity of a patient;
wherein the cuff includes a plurality of electrodes electrically connectable to an interferential current supply that supplies current to the plurality of electrodes; and
wherein the electrodes supply electrical impulses to the extremity of the patient in response to the current received from the interferential current supply, the plurality of electrodes comprising a first pair of electrodes supplying a first electrical impulse at a first frequency, and a second pair of electrodes supplying a second electrical impulse at a second frequency different from the first frequency;
wherein the first and second pairs of electrodes are positioned on the cuff such that the first and second electrical impulses intersect at a target area; and
wherein the interferential current supply simultaneously supplies current to the first and second pairs of electrodes such that the first and second electrical impulses give rise to at least one beat impulse having an interference frequency lower than the first and second frequencies at the target area.

US Pat. No. 10,456,567

TOPICAL COOLED DERMAL DEVICE

7. A method for conditioning a user's skin, the method implemented by a dermal device for skincare therapy including a fluid circuit including a fluid pump and a reservoir, and a dermal interface configured to contact the user's skin, the dermal interface including at least one electrode and being configured to contact the user's skin and further including part of the fluid circuit having at least one perforation, the at least one electrode being supported by a portion of the fluid circuit that directly contacts the user's skin and that is adjacent to the at least one perforation, wherein the at least one electrode is configured to deliver at least one energy pulse to the contacted skin, wherein the reservoir is configured to hold at least one topical, wherein the fluid pump is configured to pump the at least one topical through the fluid circuit and extrude the at least one topical through the dermal interface, wherein the fluid circuit has a curved shape at a distal portion of the dermal device that supports the at least one perforation and the at least one electrode, and the at least one perforation and the at least one electrode are configured to be disposed adjacent to each other along a portion of the curved shape that is configured to face the user's skin, the method comprising:chilling the at least one topical; and
applying the chilled at least one topical and the at least one energy pulse to the skin.

US Pat. No. 10,456,558

APPARATUS AND METHODS FACILITATING THE REPOSITIONING OF IMPLANTED MEDICAL DEVICES

Medtonic, Inc., Minneapo...

1. A method for dislodging an anchor sleeve from around a body of an implanted elongate medical device, the method comprising:engaging a collar of a support portion of a tool with the implanted elongate medical device by positioning the collar of the support portion of the tool around the body of the implanted elongate medical device and adjacent to a distal end of the anchor sleeve;
positioning a sleeve dislodging element of the tool adjacent to a proximal end of the anchor sleeve opposite the distal end;
moving the positioned dislodging element toward the engaged collar to dislodge the anchor sleeve.

US Pat. No. 10,456,556

STEERING TOOL WITH ENHANCED FLEXIBILITY AND TRACKABILITY

Bendit Technologies Ltd.,...

1. A steering tool comprising:an internal tube disposed inside an external tube, said internal and external tubes being arranged for longitudinal axial movement relative to one another, wherein a distal portion of said internal tube is fixedly joined to a distal portion of said external tube at a joining zone, and
said internal tube or said external tube is formed with patterns of cuts made along adjacent longitudinal stations along a length thereof, and wherein a cutting pattern at a first longitudinal station is shifted with respect to a cutting pattern at a second longitudinal station and a cutting pattern at the second longitudinal station is shifted with respect to a cutting pattern at a third longitudinal station but at a different shift defined between said first and second longitudinal stations, so that a shift from one longitudinal station of cuts to the next adjacent longitudinal station of cuts is not repeated, and wherein at each of said longitudinal stations said cuts are separated from each other by a separation and centers of the separations of said first, second and third longitudinal stations, when said internal tube or said external tube is in an unfolded position as a flat type sheet, do not lie on a common straight axis, wherein said common straight axis touches and is centered on each of the separations.

US Pat. No. 10,456,554

DEVICE DELIVERY CATHETER HAVING A CURVED DISTAL TIP

1. A catheter comprising:a catheter shaft having a proximal end, a distal end, an intermediate section between the proximal end and the distal end, and a curved surface reducing a diameter of the catheter shaft at the intermediate section, the catheter shaft having a central lumen and defining a central longitudinal axis;
a tip secured to the distal end of the catheter shaft, the tip being flexible and having a first end, a second end, and a central longitudinal axis extending between the first and second ends, the longitudinal axis of the tip defining an arcuate shape in the unbiased state, the arcuate shape having a concave side and a convex side; and
a device secured to the catheter shaft at the intermediate section, the device including a restraining system including a constraining sheath and a release line for releasing the constraining sheath, the restraining system being mounted such that the release line exits the catheter shaft at the curved surface of the catheter shaft and extends toward the tip and is maintained in longitudinal alignment with the concave side of the arcuate shape defined by the longitudinal axis of the tip.

US Pat. No. 10,456,553

DEVICE AND METHODS FOR TARGETED TISSUE DRUG DELIVERY

Native Cardio, Inc., Nap...

1. A minimally invasive device for treatment of a patient, the device comprising:a. at least one inner catheter adapted to deliver a drug to a cardiac surface of the patient;
b. an outer catheter substantially surrounding the at least one inner catheter;
c. a plurality of electrically conductive elements within the inner catheter and extending to be also located at a substantially distal portion of the device; and
d. at least one membrane interconnecting the plurality of electrically conductive elements at the substantially distal portion of the device,
wherein the plurality of electrically conductive elements are adapted to provide defibrillation energy to a cardiac surface of the patient.

US Pat. No. 10,456,550

DEVICE AND METHOD FOR CONTROLLING RESPIRATION DURING SLEEP

Yeda Research and Develop...

17. A device for reducing a probability of snoring during sleep, the device comprising:an odor disperser adapted to disperse an odor;
at least one detector adapted to detect a physiological characteristic of a user;
a controller configured for reducing the probability of snoring by the user by instructing the odor dispenser to disperse an odor responsive to detections by the at least one detector thereby affecting one or more upcoming breaths of the user consecutive to said odor dispersion to increase inhalation volume.

US Pat. No. 10,456,548

INFLATION CONTROL VALVES FOR RESUSCITATOR DEVICES AND RESUSCITATOR DEVICES

Emory University, Atlant...

1. An inlet valve for a resuscitator device having a flexible chamber that extends from a first end to a second end, the second end being configured to attach to an airway adjunct, comprising:a valve housing configured to be disposed at the first end of the flexible chamber and to receive air for inflating the flexible chamber, the valve housing being partially disposed within the flexible chamber,
the valve housing extending between a first end and a second end that is parallel to and opposes the first end,
the first end of the valve housing including an opening,
the second end of the valve housing being closed and being configured to be disposed within the flexible chamber,
the valve housing including a first portion, a second portion, and a third portion that are disposed between the first end and the second end of the valve housing,
the third portion being disposed between the first portion and the second portion,
the first portion including the first end of the valve housing and including a one-way valve disposed at the opening of the first end of the valve housing, the one-way valve being configured to intake the air for inflating the flexible chamber,
the second portion including the second end of the valve housing and an outlet section that includes an opening,
the outlet section being configured to deliver the air into the flexible chamber and extending perpendicular to the first end and the second end of the valve housing; and
an inflation control member configured to control a rate of inflation of the flexible chamber, the inflation control member being disposed within the valve housing and movable with respect to the valve housing between the first end and the second end of the valve housing.

US Pat. No. 10,456,537

DEVICES AND METHODS FOR DELIVERING DRY POWDER MEDICAMENTS

CONCENTRX PHARMACEUTICALS...

1. An apparatus, comprising:a first member defining at least a portion of a disaggregation chamber containing a dry powder, the first member including a chamber wall that forms an outer boundary of the disaggregation chamber; and
a second member coupled to the first member, the second member including a surface covering the disaggregation chamber, the second member defining an intake channel and an exit channel, the exit channel configured to be fluidically coupled to the disaggregation chamber via an exit opening defined by the surface of the second member, the intake channel configured to be fluidically coupled to the disaggregation chamber via an intake port, a center line of a portion of the intake channel being tangential to a portion of the chamber wall of the first member such that a portion of an inlet airflow conveyed into the disaggregation chamber via the intake channel has a rotational motion about a center axis of the disaggregation chamber, the intake port defined at least in part by an intake ramp, the intake ramp including a transition surface that forms an exit angle with respect to the surface of between 75 degrees and 105 degrees.

US Pat. No. 10,456,531

INJECTION DEVICE

SHL Group AB, Zug (CH)

1. A medicament injection device comprising:a needle shield;
a plunger; and
a tubular rotator, wherein:
said tubular rotator is configured to be rotationally and slidably arrangeable at least partially inside said needle shield of said medicament injection device, and said tubular rotator is configured to slidably and moveably receive said plunger of the medicament injection device inside, so as to enable a relative movement between said tubular rotator, said needle shield, and said plunger,
said tubular rotator comprises a plurality of ridges and a plurality of protrusions on an outer surface of said tubular rotator,
one or more of at least one of the plurality of ridges or at least one of the plurality of protrusions are configured to slide on guide members arranged on an inner surface of the needle shield, so as to cause relative rotation between the tubular rotator and the needle shield, and
said relative rotation causes the plunger to move from a first position in which said tubular rotator restricts movement of the plunger to a second position in which the plunger is allowed to act on a content of said medicament injection device.

US Pat. No. 10,456,530

SUPPLEMENTARY DEVICE FOR ATTACHMENT TO A DRUG INJECTION DEVICE FOR MONITORING INJECTION DOSES HAVING OCR IMAGING SYSTEM WITH GLARE REDUCTION

Sanofi-Aventis Deutschlan...

1. A supplementary device for attachment to an injection device, the supplementary device comprising:an imaging device configured to capture an image of a moveable number sleeve of the injection device;
a plurality of light sources comprising a first group of light sources and a second group of light sources; and
a processor configured to control operation of the imaging device and plurality of light sources and to receive image data from the imaging device,
wherein the processor is configured to:
activate the plurality of light sources sequentially by being configured to activate the first group of light sources followed by the second group of light sources;
capture a first image of the moveable number sleeve when the first group of light sources are activated;
capture a second image of the moveable number sleeve when the second group of light sources are activated;
divide the field of view of the imaging device into a central section and two peripheral sections and to associate the central section with a first illumination condition and the two peripheral sections with a second illumination condition; and
combine the first image of the moveable number sleeve and the second image of the moveable number sleeve into a single image.

US Pat. No. 10,456,529

DRUG INJECTION DEVICE WITH RESETTABLE MECHANISM ALLOWING PISTON ROD RETRACTION UPON DRUG CARTRIDGE CHANGE

Sanofi, Paris (FR)

1. A drug delivery device for selecting and dispensing a number of user variable doses of a medicament, the drug delivery device comprising:a housing;
a dose setting element rotatable relative to the housing during dose setting and dose dispensing;
a drive member coupled to the dose setting element via a clutch;
a piston rod coupled to the housing and to the drive member;
a cartridge holder removably attached to the housing and a reset element, which is permanently rotationally constrained to the housing and rotationally constrained to the drive member during dose setting; and
at least one spring acting on the reset element,
wherein if the cartridge holder is detached from the housing, the reset element is axially moved relative to the housing into a position in which the drive member is allowed to rotate relative to the housing, and
wherein the drive member is axially movable relative to the housing between a dose setting position and a dose dispensing position, wherein in the dose setting position, if the cartridge holder is attached to the housing, the drive member is rotationally constrained to the housing via the reset element, and wherein in the dose dispensing position, if the cartridge holder is attached to the housing, the drive member is rotatable relative to the reset element and the housing.

US Pat. No. 10,456,525

DETENT MECHANISM FOR A MEDICAMENT DELIVERY DEVICE

Sanofi-Aventis Deutschlan...

1. An auto-injector comprisinga syringe carrier adapted to contain at least a majority of a syringe, the syringe carrier having a ramp member with a first ramp and a second ramp, wherein the ramp member defines a longitudinal axis; and
a chassis including a resilient beam having a beam head adapted to engage the ramp member, wherein the carrier is slidably arranged in the chassis,
wherein the first ramp is adapted to deflect the beam head in a radial direction relative to the chassis, when the syringe carrier moves in a first direction relative to the chassis, and the second ramp is adapted to deflect the beam head in a tangential direction relative to the chassis, wherein the radial direction is perpendicular to the longitudinal axis, and wherein the tangential direction is perpendicular to the longitudinal axis and the radial direction
wherein the beam head is configured to be deflected by the first ramp when the syringe carrier moves in the first direction relative to the chassis, and the beam head is configured to be deflected by the second ramp when the syringe carrier moves in a second direction relative to the chassis, wherein the first direction is opposite the second direction.

US Pat. No. 10,456,519

APPARATUS AND METHOD FOR IRRIGATING SINUS CAVITY

Acclarent, Inc., Irvine,...

1. A device comprising a catheter having a proximal end and a distal end, wherein at least a portion of the catheter is sized to pass through a nasal cavity and through a sinus ostium to enter a paranasal sinus cavity, the catheter comprising:(i) a dilator disposed at the distal end, wherein the dilator is configured to transition between a non-expanded configuration and an expanded configuration, wherein the dilator is configured to fit the ostium in the non-expanded configuration, and wherein the dilator is configured to dilate the ostium in the expanded configuration,
(ii) an occluding balloon disposed at the distal end, wherein the occluding balloon is configured to transition between a non-expanded configuration and an expanded configuration, wherein the occluding balloon is configured to fit in the ostium in the non-expanded configuration, and wherein the occluding balloon is configured to sealingly engage the ostium in the expanded configuration while the dilator is in the non-expanded configuration,
(iii) a plurality of irrigation ports disposed in a sidewall at the distal end, wherein the occluding balloon is located proximal to the irrigation ports,
(iv) a suction port disposed on a distal face of the distal end, proximate to the irrigation ports, wherein the occluding balloon is located proximal to the suction port, and
(v) a plurality of lumens, the plurality of lumens including:
(i) a first lumen in fluid communication with the dilator,
(ii) a second lumen in fluid communication with the occluding balloon,
(iii) a third lumen in fluid communication with the irrigation ports, and
(iv) a fourth lumen in fluid communication with the suction port,
wherein the first, second, third, and fourth lumens are in fluid isolation relative to each other.

US Pat. No. 10,456,518

ARTERIAL CANNULA WHICH ALLOWS PERFUSION ALONG OPPOSING DIRECTIONS WITHIN A CANNULATED VESSEL

1. A cannula structure configured for cannulating an anatomical vessel of a body of a patient through a vessel entry point and delivering oxygenated blood into the vessel during a veno-arterial extra-corporeal membrane oxygenation (VA ECMO) procedure or a cardiopulmonary bypass procedure, the vessel having a superficial wall and a central axis definable within the vessel, the cannula structure formed as an elongate tubular structure having a length, and comprising:a proximal opening, which is disposed outside of the patient's body and by which oxygenated blood is introduced into the cannula structure for delivery into the vessel during the VA ECMO procedure or cardiopulmonary bypass procedure;
a plurality of fluid outputs, each of the plurality of fluid outputs fluidically coupled along the length of the cannula structure to the proximal opening of the cannula structure, the plurality of fluid outputs comprising:
a distal opening configured for outputting into the vessel a first portion of said oxygenated blood during the VA ECMO procedure or cardiopulmonary bypass procedure in a first direction toward the patient's heart; and
a set of fenestrations that is distinct and spaced proximally away from the distal opening, the set of fenestrations configured for outputting into the vessel a second portion of said oxygenated blood during the VA ECMO procedure or cardiopulmonary bypass procedure in a second direction counter to the first direction away from the patient's heart, simultaneous with the distal opening outputting the first portion of said oxygenated blood in the first direction during the VA ECMO procedure or cardiopulmonary bypass procedure;
and
a first tube disposed distal to the cannula structure's proximal opening, the first tube having an elongate length along which a plurality of fluidically coupled lumens extend therethrough, the first tube comprising:
a first segment configured to entirely reside within the vessel when the vessel is cannulated, the first segment comprising:
a first lumen having a proximal fluid input fluidically coupled to the proximal opening of the cannula structure and which is configured for receiving said oxygenated blood during the VA ECMO procedure or cardiopulmonary bypass procedure;
an elongate projecting portion through which the first lumen extends; and
the cannula structure's plurality of fluid outputs,
wherein the distal opening resides near or at a distal end of the first tube,
wherein the elongate projecting portion extends between the distal opening and the set of fenestrations,
wherein the set of fenestrations resides on a section of the first segment that is (a) proximal to the elongate projecting portion, (b) configured to remain angulated within the vessel during the VA ECMO procedure or cardiopulmonary bypass procedure, and (c) disposed substantially beneath the vessel entry point such that the set of fenestrations outputs the second portion of said oxygenated blood substantially beneath the vessel entry point during the VA ECMO procedure or cardiopulmonary bypass procedure, and
wherein during the VA ECMO procedure or cardiopulmonary bypass procedure, a vector flow component along the central axis of the vessel corresponding to the second portion of said oxygenated blood output by the set of fenestrations is antiparallel to a vector flow component along the central axis of the vessel corresponding to the first portion of said oxygenated blood output by the distal opening;
a second segment proximal to the first segment and configured to essentially entirely reside external to the vessel when the vessel is cannulated, which comprises a second lumen aligned with the first lumen of the first segment, and which between the cannula structure's proximal opening and distal opening is fluidically coupled to each of the cannula structure's proximal opening, the proximal fluid input of the first segment, the first lumen of the first segment, and the cannula structure's plurality of fluid outputs, and which is configured for receiving said oxygenated blood from the cannula structure's proximal opening and delivering said oxygenated blood into the proximal fluid input of the first segment during the VA ECMO procedure or cardiopulmonary bypass procedure; and
an expandable or inflatable cuff which prior to and after expansion or inflation is disposed distal to the second segment and around the first segment at a first segment location proximal to the set of fenestrations, wherein the expandable or inflatable cuff when expanded or inflated has a cross sectional area that is larger than each of a cross sectional area of the vessel entry point and the first segment at the location around the first segment at which the expandable or inflatable cuff is disposed, and wherein the expandable or inflatable cuff comprises:
a sleeve;
a plurality of flange members disposed about the sleeve and configured for expansion away from or contraction toward the first lumen; and
an activation member coupled to the sleeve and configured for selectively expanding or contracting the plurality of flange members,
wherein the expandable or inflatable cuff is configured for allowing blood flow around unflanged portions thereof,
wherein the expandable or inflatable cuff when expanded or inflated is configured to reside entirely within the vessel in a position substantially beneath and immediate to the vessel entry point adjacent to the superficial wall of the vessel, proximal to the set of fenestrations relative to the length of the first tube when the vessel is cannulated and the first tube is in a correct position within the vessel during the VA ECMO procedure or cardiopulmonary bypass procedure.

US Pat. No. 10,456,497

PROTECTIVE DRESSING FOR SKIN-PLACED MEDICAL DEVICE

C. R. Bard, Inc., Murray...

17. A dressing for covering a medical device on a skin surface of a patient, comprising:a release layer;
a dressing portion removably attached to the release layer, the dressing portion configured to rest against the skin surface of the patient, the dressing portion defining a hole having an outer perimeter;
a polymeric cover film attached to the dressing portion, the polymeric cover film including a pliable domed portion having a shape corresponding to the outer perimeter of the hole of the dressing portion, the pliable domed portion defining a cavity configured to receive therein the medical device when the dressing is placed on the skin surface of the patient;
a support frame removably attached to the polymeric cover film configured to provide rigidity to the dressing; and
a securement component removably attached to the support frame, the securement component configured to secure a portion of the medical device, wherein the support frame includes a gap configured to enable the securement component to be removed from the support frame and attached to the polymeric cover film without removing the support frame from the polymeric cover film.

US Pat. No. 10,456,495

PACKAGING DEVICE FOR MEDICAL PRODUCTS TO BE STERILIZED OR HAVING BEEN STERILIZED COMPRISING INTERNAL FIXATION

B. Braun Melsungen AG, (...

1. A packaging device comprising:a receiving compartment for medical products to be sterilized or having been sterilized, the receiving compartment sealable in a sterile manner; and
a carrier configured to at least one of hang, guide, or handle the packaging device, the carrier extending into an interior of the receiving compartment and comprising at least one fitting mount for a section of a medical product to be sterilized or having been sterilized,
the carrier comprising an outer guiding section configured to at least one of hang, guide, or handle the packaging device,
the receiving compartment being formed by a film package,
a bonded connection being formed between the carrier and the film package at an interface where the carrier extends into the receiving compartment, and
the outer guiding section projecting through the bonded connection and outside of the film package.

US Pat. No. 10,456,481

DUALLY DERIVATIZED CHITOSAN NANOPARTICLES AND METHODS OF MAKING AND USING THE SAME FOR GENE TRANSFER IN VIVO

1. A method of treating diabetes in a patient in need thereof, the method comprising administering a therapeutically effective amount of a therapeutic nucleic acid encoding insulin, a glucagon antagonist, GLP-1 or leptin to a target tissue in the patient, wherein said administering comprises contacting said target tissue with a dually derivatized (DD) chitosan nucleic acid polyplex, said DD chitosan nucleic acid polyplex comprising a chitosan-derivative nanoparticle and said therapeutic nucleic acid, wherein said chitosan-derivative nanoparticle comprises chitosan functionalized with arginine (Arg) and a hydrophilic polyol (HP) of Formula VII:
wherein:
R2 is selected from: H and hydroxyl;
R3 is selected from: H and hydroxyl; and
X is selected from: C2-C6 alkylene optionally substituted with one or more hydroxyl substituents;provided said hydrophilic polyol is not gluconic acid.

US Pat. No. 10,456,469

GLUTAMINE-HIGH Z ELEMENT COMPOUNDS FOR TREATING CANCER

SERBIG PHARMACEUTICALS CO...

1. A method for treating tumorigenic cells by targeting the cells mitochondria comprising:treating the tumorigenic cells with a radiosensitizing containing glutamine-ligand-high Z element compound and also treating the tumorigenic cells with a high energy radiation,
wherein the glutamine-ligand-high Z element compound is selected from the group consisting of the compounds provided below:

US Pat. No. 10,456,422

SURGICAL WOUND HEALING COMPOSITION AND METHOD OF APPLYING THE SAME

1. A method for improving the survival rate of a hair follicular graft during a hair transplantation surgery from a donor site to a recipient site, the method comprising injecting, proximal to the recipient site, a therapeutically effective amount of a suspension comprising:an autologous platelet solution above basal concentration;
granulated extracellular matrix; and
triamcinolone acetonide;
wherein administration of the therapeutically effective amount of the suspension is operative to decrease the scarring rate at the recipient site by more than 50%, increase the pigmentation retention rate of the hair follicular graft, and increase the survival rate of the hair follicular graft.

US Pat. No. 10,456,414

METHODS FOR TREATING HCV

Gilead Pharmasset LLC, F...

1. A composition comprising compound 10 having the structure:
or a pharmaceutically acceptable salt thereof, and compound 6 having the structure:

or a pharmaceutically acceptable salt thereof.

US Pat. No. 10,456,408

METHODS FOR TREATING SUBJECTS WITH PRADER-WILLI SYNDROME OR SMITH-MAGENIS SYNDROME

ESSENTIALIS, INC., Redwo...

1. A method of reducing hyperghrelinemia in a subject having Prader-Willi syndrome (PWS) or Smith-Magenis syndrome (SMS), comprising administering to said subject for at least 10 weeks a pharmaceutical formulation comprising an effective amount of a KATP channel opener,and wherein the method does not comprise administering human growth hormone to the subject.

US Pat. No. 10,456,371

SUBSTITUTED ESTERS CONTAINING POLYOLS AND SACCHARIDES FOR TREATING HEPATOTOXICITY AND FATTY LIVER DISEASES

SINEW PHARMA INC., Taipe...

13. A pharmaceutical composition comprising a compound of claim 1, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.

US Pat. No. 10,456,360

STABILIZING CAMPTOTHECIN PHARMACEUTICAL COMPOSITIONS

Ipsen Biopharm Ltd., (GB...

1. A storage stabilized liposomal irinotecan composition comprising irinotecan sucrose octasulfate (SOS) encapsulated in liposomes comprised of cholesterol and one or more phospholipids with a ratio corresponding to a total of 500 grams±10% by weight irinotecan moiety per mol total phospholipids, the liposomal irinotecan composition stabilized to have less than 20 mol %, with respect to total phospholipids, of lyso-phosphatidylcholine (lyso-PC) during the first 6 months of storage of the liposomal irinotecan composition at a temperature ranging from 2 to 8° C., the liposomal irinotecan composition obtained by a process comprising the steps of:(a) forming liposomes comprising 1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC), cholesterol, and methoxy-terminated polyethylene glycol-distearoylphosphatidyl ethanolamine, encapsulating a substituted ammonium salt of SOS with a sulfate concentration of from 0.4 to 0.5 M;
(b) contacting the liposomes with a solution comprising irinotecan, at a temperature above the transition temperature of the component phospholipids, thereby forming a preparation of liposomes encapsulating irinotecan sucrose octasulfate within the liposomes; and
(c) obtaining the storage stabilized liposomal irinotecan composition by at least one additional step comprising adjusting the pH of the preparation of liposomes from step (b) to a pH of from about 7.25 to about 7.50.

US Pat. No. 10,456,334

CREAM-TYPE HAIR COLORING AGENT

1. Agent for oxidative hair dyeing comprising, relative to the weight of the agent,from about 60 to about 83 wt. % water,
at least one oxidation dye precursor,
at least one alkalizing agent,
at least one cross-linked copolymer, constructed from acrylic acid and non-ethoxylated esters of acrylic acid with linear C10-C30 mono-alcohols as monomers, wherein the cross-linked copolymer is included in a total quantity of from about 0.08 to about 0.8 wt. %, relative to the weight of the agent,
at least one linear, saturated 1-alkanol with a hydroxy group and from about 8 to about 22 carbon atoms in a total amount of from about 8 to about 15 wt. %,
at least one saturated or unsaturated alkane carboxylic acid with from about 14 to about 22 carbon atoms or a salt thereof in a total amount of from about 0.1 to about 2 wt. %,
in a total quantity of from about 1 to about 5% wt. %, at least one glycerol fatty acid from Formula (I)
whereR1, R2 and R3 each independently of one another denote a hydrogen atom or a grouping in Formula (II),
whereR4 denotes an unbranched or branched, saturated or unsaturated C11-C27 alkyl group, providing that at least one and a maximum of two of the radicals, selected from R1, R2, and R3, denotes a grouping of Formula (II);
in addition to the aforementioned substances, at least one other surfactant, selected from anionic, zwitterionic, amphoteric and non-ionic surfactants and mixtures thereof, in a total quantity of from about 1 to about 6 wt. %, and which do not contain any oxidants, and
at least one of branched alkanol with a hydroxy group and from about 10 to about 50 carbon atoms,
wherein the agent has a viscosity of from about 22,000 to about 27,000 mPas when measured at 20° C. using a rotational viscometer at a rotational frequency of 7.2 s?1 with measurement geometry SV II.

US Pat. No. 10,456,325

MICRO FACIAL MASSAGER

1. A micro facial massager, comprising:a housing;
a circuit board;
a driving motor;
an eccentric wheel arranged on an output shaft of the driving motor;
a massage piece;
at least one battery positioned in a placed groove of a battery box;
two metal connectors; and
wherein a through hole is defined in a bottom of the placed groove; the battery box is dismountable and is insertable into the housing; the two metal connectors are corresponding fixed in the housing and are connected with the circuit board; the two metal connectors press an anode and a cathode of the at least one battery when the battery box is inserted into the housing, respectively;
two supporting structures are formed on a first side of the housing to hold up the battery box, and two sliding structures are formed on two sides of the battery box to engage with the two supporting structures, respectively; a clamp is formed on a top end of each of the two sliding structures, a stuck column is formed on a front end of each of the two supporting structures to engage with the clamp.

US Pat. No. 10,456,322

MASSAGE SHOWER HEAD

PURITY (XIAMEN) SANITARY ...

1. A massage shower head, comprising a main body, a water outlet cover and a plurality of massage balls; the main body being provided with a water inlet, a front of the main body being defined as a water outlet side, the water outlet cover covering the water outlet side of the main body, the massage balls being movably disposed between the main body and the water outlet cover, the water outlet cover having a plurality of openings, the massage balls partially extending out from the openings respectively, and further comprising a multifunctional sealing seat and a water outlet sleeve; the multifunctional sealing seat being mounted on the front of the main body, the multifunctional sealing seat being provided with a plurality of water drain holes communicated with the water inlet; the water outlet cover covering the multifunctional sealing seat, an inner side of the water outlet cover being formed with a plurality of partitions, the partitions dividing the inner side of the water outlet cover into a plurality of independent water chambers and accommodation chambers, the water chambers being in communication with the plurality of water drain holes respectively, the water outlet cover being formed with a plurality of insertion holes corresponding in position to the water chambers, the water outlet sleeve being disposed between the water outlet cover and the multifunctional sealing seat and attached to the inner side of the water outlet cover, the water outlet sleeve being formed with a plurality of guide posts with water apertures corresponding to the insertion holes, the guide posts passing through the insertion holes of the water outlet cover respectively; the massage balls being movably disposed in the accommodation chambers respectively, the openings corresponding in position to the accommodation chambers.

US Pat. No. 10,456,317

SYSTEM AND METHOD FOR CONTROLLING JOINT ANGLE OF KNEE-JOINT TYPE WALKING TRAINING ROBOT

KOREA POLYTECHNIC UNIVERS...

1. A system for controlling a joint angle of a knee-joint type walking training robot, the system comprising:a pressure measuring apparatus configured to measure a pressure of a sole of a foot of a walker by using a pressure sensor; and
a joint angle estimating apparatus configured to estimate a joint angle of a knee-joint by extracting a movement time period for walking and a length by which the foot sole makes contact with a ground surface based on the pressure of the foot sole measured by the pressure measuring apparatus,
wherein the joint angle estimating apparatus comprises:
a receiver for receiving pressure values transmitted by a transmitter;
a pressure extracting circuit configured to estimate a gait phase for the received pressure values; and
a joint angle estimating circuit configured to estimate the joint angle of the knee-joint during walking by estimating an angle between the foot sole and the ground surface according to the gait phase estimated by the pressure extracting circuit.

US Pat. No. 10,456,306

ABSORBENT ARTICLES WITH IMPROVED ABSORPTION PROPERTIES

1. An absorbent article comprising a topsheet and a backsheet, and an absorbent structure comprising an absorbent core; wherein the absorbent article is divided into three portions: a front portion, a back portion and a crotch portion disposed between the front portion and the back portion, and wherein the absorbent article comprises an acquisition time for the first gush of less than about 27 s as measured according to the Flat Acquisition Test Method, wherein one or more portions of the absorbent structure comprises a Kmin/K20 ratio of 0.75 or greater.

US Pat. No. 10,456,305

PACKAGE FOR ABSORBENT ARTICLES FORMING A THREE-DIMENSIONAL BASIN

1. A package comprising at least one stack of compressed absorbent articles, wherein each article extends in longitudinal direction and a transversal direction, and comprises:a topsheet;
a backsheet;
an absorbent core between the topsheet and the backsheet,wherein the absorbent core comprises an absorbent layer in a core wrap, the absorbent layer comprising an absorbent material and having a longitudinally extending central portion, a first side portion disposed transversally outward of the central portion and a second side portion disposed transversally outward of the central portion on another side of the central portion;wherein the absorbent core further comprises a first folding guide between the central portion and the first side portion, and a second folding guide between the central portion and the second side portion;wherein each side portion comprises a plurality of winglets, each winglet having a proximal side relative to a folding guide and extending outward from this proximal side, and wherein neighboring winglets are separated by a gap between their neighboring sides;wherein each of the first folding guide and the second folding guide are substantially free of absorbent material;wherein each of the first folding guide and the second folding guide substantially continuously extend from a first location of a longitudinally-extending side edge of the absorbent core to a second location of the longitudinally-extending side edge of the absorbent core; andwherein in the package, the articles are bi-folded along a transversal fold line and are compressed at an In-Bag Compression Rate of from 5% to 50%.

US Pat. No. 10,456,298

SYSTEMS AND METHODS FOR THE TREATMENT OF EYE CONDITIONS

Tear Film Innovations, In...

1. A device for treating a mammalian eye having an eyelid, comprising:a shield formed of a plate positionable proximate an inner surface of an eyelid, the shield including an energy-reflecting material that reflects light energy;
an energy transducer having a device that emits light energy, the energy transducer positionable outside of the eyelid when the shield is positioned proximate the inner surface of the eyelid, wherein the energy transducer provides light energy toward the energy-reflecting material at one or more wavelengths, including a first wavelength selected to at least partially pass through the eyelid to the shield and at least partially reflect back toward a target tissue region from the shield; and
an energy transmission surface positioned in a spaced relationship with the shield;
a housing, wherein the shield, the energy transducer, and the energy transmission surface are mechanically coupled to the housing;
an actuator coupled to the housing, wherein actuation of the actuator causes relative movement between the energy transmission surface and the shield so as to modify the spaced relationship;
wherein when the eyelid is positioned between the energy transducer and the shield, the light energy from the energy transducer passes through the eyelid and reflects off the shield.

US Pat. No. 10,456,286

TORQUE-COMPENSATING ASSISTIVE WRIST BRACES

The Regents of the Univer...

1. A torque-compensating assistive wrist brace comprising:a hand member adapted to attach to a user's hand, the hand member comprising a continuous band having a relative wide finger passage through which the user's fingers can pass and a smaller thumb passage through which the user's thumb can pass;
a forearm member adapted to attach to the user's forearm, the forearm member including a body and mounting elements provided on the body that form pivot points of the wrist brace; and
an assistive linkage that connects the hand and forearm members together, the assistive linkage comprising one or more spring-assisted six-bar linkages and a transverse shaft, each spring-assisted six-bar linkage provided on a lateral side of the wrist brace, each spring-assisted six-bar linkage including four binary links, two ternary links, and a biasing element that together apply a balancing torque to a wrist of the user that counteracts intrinsic stiffness within the wrist and assists the user in rotating the wrist in both the flexion and extension directions;
wherein the mounting elements comprise a first pair of laterally spaced mounting arms that extend from a distal end of the body of the forearm member on opposed lateral sides of the body;
wherein the mounting elements further comprise a top mounting element that includes a central longitudinal flange that extends upward from the body and a second pair of laterally spaced mounting arms that extend laterally from the longitudinal flange and then forward toward the distal end of the body;
wherein the mounting arms each include an opening that defines a location of a pivot point for links of the one or more spring-assisted six-bar linkages, and wherein the central longitudinal flange includes an opening adapted to receive the transverse shaft upon which links of the one or more spring-assisted six-bar linkages are mounted;
wherein a first binary link of each spring-assisted six-bar linkage is fixedly attached to a lateral side of the hand member, pivotally connected to one of the mounting elements of the forearm member, and pivotally connected to a first ternary link of the corresponding spring-assisted six-bar linkage.

US Pat. No. 10,456,280

SYSTEMS AND METHODS OF USING A BRAIDED IMPLANT

DePuy Synthes Products, I...

1. A system for treating an aneurysm, comprising:a plurality of braided implants, wherein each braided implant comprises a porosity of 65%-70% that is consistent over a different 1 mm diameter range in a diameter of a vessel, each braided implant configured to provide the consistent porosity over different 1 mm diameter ranges.

US Pat. No. 10,456,279

STENT FOR BIFURCATION, A SYSTEM FOR INTRAVASCULAR IMPLANTATION OF THE STENT FOR BIFURCATION AND A METHOD OF IMPLANTATION OF THE STENT FOR BIFURCATION

BALTON SP. Z O.O., (PL)

1. A method of introducing and positioning a stent for bifurcation by an intravascular implantation system including:a stent, an external tube, an internal tube marked with a ring visible on an X-ray image, and a profiled balloon;
the profiled balloon comprises a proximal part fastened to an external surface of the external tube, and a distal part fastened to an external surface of the internal tube, the proximal part of greater diameter than the distal part, and a medial part having length of 0.5 to 8 mm and located between the distal part and the proximal part,
wherein the distal part, the proximal part and the medial part of the profiled balloon are non-separable;
the stent comprising a distal cylindrical part, a proximal cylindrical part of greater diameter than the distal part, and two longitudinal connectors connecting the distal part and the proximal part of the stent; and
the two longitudinal connectors arranged on opposite sides of the stent and having lengths of 0.5 to 8 mm and forming a cell of the stent with a surface area enlarged compared with the surface area of the distal cylindrical part, the two longitudinal connectors having a curvilinear shape and clamped on the profiled balloon in a detachable way,
wherein a position of the ring coincides with the proximal edge of the distal part of the stent clamped on the profiled balloon,
wherein upon clamping the stent in a separable way on the profiled balloon, the cell encompasses the medial part of the profiled balloon, the method comprising:
introducing a guide wire to a main branch of a vessel at a bifurcation site;
introducing at the bifurcation site the system including the stent,
wherein the ring signifies a position of edges of the proximal distal part of the stent clamped on the balloon being positioned precisely at a groin of a vessel, so that the distal part of the stent is situated behind a fork of the vessel, in the main branch, the proximal part of the stent is situated before the fork of an artery, and the medial part of the stent, with the cell of the stent positioned in a lumen of the lateral branch of the vessel; and then
when fluid under pressure of 6 to 20 atm is introduced to the profiled balloon, implanting the stent;
removing the fluid from the profiled balloon; and
withdrawing the system and the guide wire.

US Pat. No. 10,456,265

FIXATION MECHANISM FOR AN IMPLANT

WRIGHT MEDICAL TECHNOLOGY...

1. An ankle prosthesis, comprising:a tibial component configured for attachment to a tibia of a person; and
a talar component having a first surface configured for facing the tibial component and a second surface configured for facing a talus of the person, the second surface having first and second arms attached thereto, for pivoting or flexing outwardly in medial and lateral directions, respectively, to engage side surfaces of a previously formed slot in the talus; and
a separator comprising at least one of a cone and a wedge, the separator being positioned between the first and second arms and attached to a threaded member for moving the separator in an anterior-posterior direction, the separator configured to be advanced towards an end of each of the first and second arms attached to the second surface, for causing the first and second arms to pivot or flex outwardly.

US Pat. No. 10,456,263

PATIENT-ADAPTED AND IMPROVED ARTICULAR IMPLANTS, DESIGNS AND RELATED GUIDE TOOLS

ConforMIS, Inc., Billeri...

1. A femoral implant for replacing a knee joint of a patient comprising:a. a medial condyle having a medial articular surface that includes a medial sagittal curve derived from a corresponding medial condyle of the knee joint of the patient;
b. a lateral condyle having a lateral articular surface that includes a lateral sagittal curve derived from a corresponding lateral condyle of the knee joint of the patient; and
c. a trochlear portion having a trochlear articular surface that includes a trochlear sagittal curve derived from the trochlear region of the knee joint of the patient; and
d. one or more additional implant features or measurements including one or more planar facets on the bone-facing surface of the femoral implant being derived from patient-specific data and a weighting of at least one parameter including preservation of bone,
wherein the medial, lateral and trochlear sagittal curves are substantially J-curves derived from the corresponding, respective medial, lateral and trochlear J-curves of the knee joint of patient.

US Pat. No. 10,456,261

DEVICES, SYSTEMS AND METHODS FOR MANUFACTURING ORTHOPEDIC IMPLANTS

ConforMIS, Inc., Billeri...

1. A fixture for use in manufacturing a surgical implant for treating a portion of a bone of a patient, the fixture comprising:an outer surface, the outer surface including:
an engagement portion configured to engage a patient-specific portion of the implant in a known orientation during at least a portion of the manufacturing of the implant; and
a connecting portion, the connecting portion configured for releasably connecting to one or more processing apparatuses in a predetermined orientation,
wherein the engagement portion includes first and second holes, the first and second holes sized and positioned to accommodate first and second pegs, respectively, extending from the implant when the implant is engaged with the engagement portion in the known orientation.

US Pat. No. 10,456,259

TRANSVALVULAR INTRAANNULAR BAND FOR MITRAL VALVE REPAIR

Heart Repair Technologies...

1. A transvalvular intraannular band, the transvalvular band comprising:an elongate body having a first end, a first anchoring portion located proximate the first end, a second end, a second anchoring portion located proximate the second end, and a central portion connected to the first end and the second end, wherein the central portion comprises a convex arcuate shape and comprises a plurality of crossing struts encapsulated by a material such that the plurality of crossing struts are fixed relative to each other, the crossing struts intersecting at an intersection zone, the central portion configured to be displaced transversely from an intraannular plane when the band is attached to an annulus; wherein the first end and the second end are configured to be attached to the annulus within the intraannular plane and the central portion is configured to be convex in a direction of outflow to support valve leaflets at a point displaced toward a ventricle from the intraannular plane, wherein the first end and the second end reside on a septal-lateral axis transverse to coaptive edges of the valve leaflets when the band is attached to the annulus, and wherein the band does not comprise an annuloplasty ring.

US Pat. No. 10,456,257

TISSUE SHAPING DEVICE

Cardiac Dimensions Pty. L...

1. A mitral valve therapy device configured for deployment within a coronary sinus, the therapy device comprising an expandable distal anchor, a proximal anchor, and an elongate body extending therebetween, the elongate body defining a longitudinal axis of the therapy device, the expandable distal anchor comprising:a flexible elongate member and a securing member for securing a first and second end of the flexible elongate member therein at a distal end of the securing member, the securing member generally aligned with the elongate body along the longitudinal axis, a first segment of the flexible elongate member extending from a distal end of the distal anchor to a proximal end of the distal anchor to engage the elongate body proximal the distal end of the elongate body, and a second segment of the flexible elongate member extending from where the first segment engages the elongate body to the distal end of the distal anchor, the first segment crossing the second segment at a location between the distal and proximal ends of the distal anchor, the distal anchor further having a collapsed configuration for delivery into the coronary sinus within a catheter and an expanded configuration for anchoring the distal anchor in the coronary sinus, the location being positioned radially outward from the securing member when the distal anchor is in the expanded configuration.

US Pat. No. 10,456,255

DISK-BASED VALVE APPARATUS AND METHOD FOR THE TREATMENT OF VALVE DYSFUNCTION

Cephea Valve Technologies...

1. A method of deploying a prosthetic cardiac valve in a patient, the method comprising:inserting the prosthetic cardiac valve in a collapsed configuration within a dysfunctional mitral valve in the patient's heart, the prosthetic cardiac valve including a distal portion, a proximal portion, and a central portion therebetween;
permitting the distal portion to self-expand such that the distal portion flares radially outward relative to the collapsed configuration and relative to the central portion, the flared distal portion forming a distal disk having a convex annular shape such that the distal disk points distally;
pulling the distal disk proximally into a plane of the dysfunctional mitral valve;
engaging mitral valve tissue with a plurality of hooks disposed on the distal disk proximal to a distal end of the prosthetic cardiac valve;
permitting the proximal portion to self-expand on an opposite side of the dysfunctional mitral valve such that the proximal portion flares radially outward relative to the collapsed configuration and relative to the central portion, the flared proximal portion forming a proximal disk, wherein pulling the distal disk proximally occurs prior in time to permitting the proximal portion to self-expand; and
permitting the central portion of the valve anchor to self-expand within the dysfunctional mitral valve to move the distal and proximal disks toward each other to compress the dysfunctional mitral valve.

US Pat. No. 10,456,249

PROSTHETIC HEART VALVE WITH PARAVALVULAR LEAK MITIGATION FEATURES

St. Jude Medical, Cardiol...

1. A prosthetic heart valve for replacing a native valve, comprising:a stent extending in an axial direction between an inflow end and an outflow end and having circumferential rows of cells formed by cell struts, the stent having a collapsed condition and an expanded condition;
a valve assembly disposed within the stent;
a first cuff disposed on a lumenal surface of the stent; and
a second cuff having a proximal edge facing toward the inflow end of the stent and a distal edge facing toward the outflow end of the stent, the second cuff being annularly disposed about one of the circumferential rows of cells and positioned radially outward of the first cuff and the stent;
wherein an ablumenal surface of selected cell struts forming the one circumferential row of cells has a concave curvature in a length direction of the selected cell struts when the stent is in the expanded condition, and
wherein each of the selected cell struts has end portions and a center portion between the end portions, and when the stent is in the expanded condition, a radial distance between the ablumenal surface of the center portion and the second cuff is greater than a radial distance between the ablumenal surface of each end portion and the second cuff,
wherein a lumenal surface of the selected cell struts is straight in the length direction of the selected cell struts when the stent is in the expanded condition.

US Pat. No. 10,456,246

INTEGRATED HYBRID HEART VALVES

Edwards Lifesciences Corp...

1. A hybrid prosthetic heart valve having an inflow end and an outflow end, comprising:a valve member including an undulating wireform with alternating cusps and commissures supporting a plurality of flexible leaflets configured to regulate one-way blood flow therethrough; and
an expandable inflow stent frame having a radially-expandable inflow end and an outflow end that undulates with peaks and valleys corresponding to an inflow end of the wireform, wherein the stent frame outflow end defines an implant circumference having a first diameter that enables physiological functioning of the valve member when implanted, and the stent frame outflow end includes integrated commissure posts located adjacent to and radially outward from the wireform commissures, the integrated commissure posts being separate elements from each other and from the stent frame and secured with sutures directly on top of and in alignment with the stent frame outflow end, each commissure post having a contoured lower ledge that matches a contour of one of the peaks in the undulating outflow end of the stent frame, the stent frame projecting in an inflow direction from an inflow end of the wireform, and further wherein the leaflets pass through the wireform commissures and attach to the commissure posts of the stent frame, wherein the stent frame outflow end permits post-implant expansion from the first diameter to an expanded diameter larger than the first diameter that disables physiological functioning of the valve member upon application of an outward dilatory force from within the outflow end substantially larger than forces associated with normal physiological use, and an identifier on the stent frame visible from outside the body after implant that identifies the stent frame as having an expandable outflow end.

US Pat. No. 10,456,237

ESOPHAGEAL STENT INCLUDING A VALVE MEMBER

BOSTON SCIENTIFIC SCIMED,...

1. An expandable medical device, comprising:a tubular scaffold, the scaffold including a first end, a second end opposite the first end, an inner surface defining a lumen extending from the first end to the second end, an outer surface opposite the inner surface, and a central longitudinal axis extending from the first end to the second end, the scaffold formed of a plurality of struts defining openings therebetween, the openings extending from the inner surface to the outer surface through a wall of the scaffold;
a flexible valve extending radially inward from the inner surface of the scaffold into the lumen of the scaffold between a first circumferential location and a second circumferential location;
an inner layer of polymer material disposed on the scaffold and extending across the openings from the first circumferential location to the first end of the scaffold and from the second circumferential location to the second end of the scaffold, the flexible valve being formed from a portion of the inner layer extending between the first circumferential location and the second circumferential location which is spaced away from the scaffold between the first circumferential location and the second circumferential location; and
an outer layer of polymer material disposed on the scaffold and extending across the openings between the first circumferential location and the second circumferential location;
wherein the inner layer is circumferentially attached to the outer layer at the first circumferential location and the inner layer is circumferentially attached to the outer layer at the second circumferential location to form an annular chamber extending circumferentially around the central longitudinal axis of the scaffold between the first circumferential location and the second circumferential location, the annular chamber bounded by an inner surface of the inner layer extending from the first circumferential location to the second circumferential location and a surface of the outer layer extending from the first circumferential location to the second circumferential location;
wherein the valve narrows from the first circumferential location to a closure point of the valve, the valve being configured to shift from a closed configuration to an open configuration;
wherein the valve is configured to permit material to pass through the closure point of the valve from the first end to the second end, wherein the valve includes a surface texture configured to prohibit material from moving through the closure point of the valve from the second end to the first end, wherein the surface texture is only on a downward facing surface of the valve located between the closure point and the second circumferential location, wherein the surface texture is on an outer surface of the inner layer opposite the inner surface of the inner layer, the inner surface of the inner layer being devoid of the surface texture.

US Pat. No. 10,456,226

TOOTH REPLACEMENT

KUZLER GMBH, Hanau (DE)

1. A tooth replacement comprising at least two adjacent posterior teeth comprising a first tooth and a second tooth adjacent to the first tooth, wherein each of the first and second teeth include a mesial contact surface, a distal contact surface, and an occlusal surface, wherein the occlusal surface comprises a least one buccal cusp having a buccal cusp tip, a lingual cusp having a lingual cusp tip, a central fissure which has at least one tooth pit and passes through the occlusal surface in a mesiodistal direction between the two cusps, a first gradient which slopes downward from the buccal cusp tip in a direction of the central fissure, and a second gradient which slopes downward from the lingual cusp tip in the direction of the central fissure, wherein the occlusal contact surface comprise expansion spaces to obtain a dynamic occlusal guidance, wherein the tooth pits of the occlusal surfaces of the first and second posterior teeth engage in an occlusion position with respective antagonists of the posterior teeth, wherein the respective antagonist teeth include a further occlusal surface having at least one further cusp, to engage in the occlusion position with the tooth pit of the occlusal surface of the posterior teeth, wherein a length of a retrusion path starting from the occlusion position is at least 0.6 mm, wherein the mesial contact surface of the first tooth is curved in a calotte-like or spherical manner, having a convex edge both in a sagittal plane and in a transverse plane, and wherein the second tooth has a distal contact surface abutting the mesial contact surface of the first tooth, wherein the distal contact surface of the second tooth is curved concavely spherically for producing a form-fit contact with a convexly curved mesial contact surface of the first tooth, thus having a concave edge both in a sagittal plane and in a transverse plane, wherein a radius of a curvature of the mesial contact surface of the first tooth is approximately equal to a radius of a curvature of the distal contact surface of the second tooth, wherein a radius of curvature of the occlusal surface of at least one of the posterior teeth as a base of the tooth pit is sectional planes running parallel to a tooth axis through the base of the tooth pit is greater than 1.2 mm and less than 5 mm.

US Pat. No. 10,456,225

METHOD FOR CLEARING OF VIRTUAL REPRESENTATIONS OF OBJECTS

A. TRON3D GMBH, Klagenfu...

1. Method for clearing, in particular for removing, unwanted data from optically detected virtual representations of objects, in particular teeth and intraoral structures, the method comprising:a. Defining an extension line of the representation,
b. Generating a projection plane at one point of the extension line, the extension line at this point being perpendicular to the generated projection plane,
c. Projecting all known points in space of the representation from one region corresponding to the projection plane onto the projection plane, the corresponding point in space being stored for each projected point,
d. Generating a two-dimensional curve on the projection plane from the projected points,
e. Determining maxima, minima and a center of the curve,
f. Identifying projected points of the curve that—viewed from the center of the curve—lie outside of the minima or maxima,
g. Removing the points in space that correspond to the projected points that were identified in f.,
h. Optionally, repeating starting from b. for one further point of the extension line.

US Pat. No. 10,456,224

METHOD FOR GUIDING DENTAL IMPLANT PLAN, APPARATUS FOR SAME, AND RECORDING MEDIUM THEREFOR

OSSTEMIMPLANT CO., LTD., ...

1. A method of implant planning guide, comprising:detecting a region where a tooth has been lost based on a tooth image;
calculating an implant area where an implant is to be placed in the region; and
displaying the implant area on the teeth image by using a pre-determined mark indicating boundaries of the implant area,
wherein the implant area is displayed separately for each of the implant objects which are parts of the implant, or the implant area is displayed integrally for all the implant objects,
wherein in case that the implant area is displayed integrally for all the implant objects, the implant area of the implant object selected by a user is separately displayed from that of the others.

US Pat. No. 10,456,220

BENDABLE PROSTHESIS POST AND ANGULAR ADJUSTMENT METHOD

DENTSCARE LTDA, Joinvill...

1. An angular adjustment method for a definitive bendable prosthetic abutment provided with a single body, the method comprising:providing a definitive bendable prosthetic abutment with a single body, the prosthetic abutment formed to have a guiding and anchoring segment (1) of the single body to guide and anchor the prosthetic abutment, a connection zone (2) of the single body connected to an end portion of the guiding and anchoring segment and extending upwardly therefrom to connect to an implant when arranged on the gingival tissue, a sacrificial and anchoring zone (3) connected to an end portion of the connection zone and having a diameter greater than a diameter of the connection zone so as to define a protuberant ring-shaped shoulder, the guiding and anchoring segment, the connection zone, and the sacrificial and anchoring zone collectively defining a lower portion of the single body, the diameter of the sacrificial and anchoring zone (3) being greater than the diameter of the largest portion of the connection zone, a bendable intermediate restriction (4) connected to the sacrificial and anchoring zone and extending upwardly therefrom and positioned to define an intermediate portion of the single body, and a mounting and fastening portion (5) having a greater cross-sectional diameter than the intermediate restriction, connected to an end portion of the intermediate restriction, and extending upwardly therefrom to receive a prosthesis to be mounted and fastened when positioned thereon, the mounting and fastening portion defining the upper portion of the single body of the definitive bendable prosthetic abutment;
positioning the guiding and anchoring segment (1) of the prosthetic abutment into a cavity (29) of a base (28) of a separate bendable device (D) so that peripheral portions of the shoulder of the sacrificial and anchoring zone (3) of the prosthetic abutment contact peripheral portions of the cavity (29) of the separate bendable device (D); and
bending an upper portion of the single body about the intermediate portion for angular orientation with respect to the lower portion when positioned in the cavity (29) of the bending device (D).

US Pat. No. 10,456,218

CONTOURED-BODY ORTHODONTIC EXPANSION SCREW

1. An orthodontic expansion apparatus for widening the maxilla of a patient, the apparatus comprising:a spindle comprising a central actuating portion, a left threaded portion and a right threaded portion on opposite sides of the central actuating portion;
a left body threadably coupled to the left threaded portion; and
a right body threadably coupled to the right threaded portion;
wherein rotating the central actuating portion causes the left body and the right body to translate in opposite directions along a longitudinal axis of the spindle between an unspread configuration with the left body and the right body proximate to the central actuating portion and a spread configuration with the left body and the right body distal to the central actuating portion, and
wherein each of the left body and right body comprise a convex curved profile in a frontal plane view configured to face a palate of the patient and to contour to a shape of a superior side of the palate,
wherein each of the left body and the right body comprise a convex curved profile in a transverse plane view configured to contour to a shape of an anterior end portion of the palate,
wherein each of the left body and the right body comprise a palatal surface configured to face the palate of the patient,
wherein the palatal surface is a substantially spherical convex surface defined by the curved profile in the transverse plane view and the curved profile in the frontal plane view, and
wherein the spherical convex surface is configured to face the palate of the patient and to contour to a shape of the anterior end portion of the palate.

US Pat. No. 10,456,216

DENTAL HAND INSTRUMENT AND HEAD HOUSING THEREFOR

1. A dental hand instrument, comprising:a grip sleeve having a front end;
a head housing arranged at the front end of the grip sleeve, the head housing including a substantially cylindrical hollow space and an inner wall region enclosing the substantially hollow space, the head housing configured to receive or hold a treatment instrument;
a spray insert arranged in the substantially cylindrical hollow space having two circumferential annular incisions;
a connecting bore located in the head housing having a first end facing the grip sleeve,
wherein the substantially cylindrical hollow space is connected by way of the connecting bore to a connection region pointing to the grip sleeve, and
wherein the first end of the connecting bore is coupled to a media line extending through the grip sleeve; and
a sickle-shaped recess located within the inner wall region of the head housing and into which the connecting bore opens.

US Pat. No. 10,456,215

SYSTEM AND METHOD FOR PLANNING A FIRST AND SECOND DENTAL RESTORATION

NOBEL BIOCARE SERVICES AG...

1. A method of planning a dental restoration for a patient, said method comprising:virtually planning a first model, via a computer, of a first dental restoration for said patient, the first dental restoration being a temporary or try-in soft tissue supported dental restoration that does not extend into bone in a virtual model of the patient, wherein the virtual planning of said first model of said first dental restoration comprises planning of a position of an implant, wherein said try-in soft tissue supported dental restoration comprises a recess, which is planned to receive the coronal portion of said implant and an impression coping or a healing cap if attached to the coronal portion of said implant when positioning said try-in dental restoration in the oral cavity of said patient when said implant is implanted therein and wherein said recess is configured to accommodate impression material for registering a position and orientation of said implant as well as of said impression coping or healing cap;
providing first production data based on said virtually planned first model of said first dental restoration useful for production of said first dental restoration for installing said first dental restoration in an oral cavity of said patient, wherein said first dental restoration includes at least a tooth;
requesting production of said first dental restoration based on said first production data to manufacture a produced first dental restoration;
obtaining said produced first dental restoration;
installing said obtained and produced first dental restoration in said patient;
providing scan data comprising factual position data and/or factual shape data, including a factual position of said implant based on at least a portion of the installed first dental restoration resulting from installing said first dental restoration in the oral cavity of the patient after modification thereof, wherein said installed first dental restoration was produced by using said first production data and wherein said scan data on said factual position of said implant is obtained from the position and orientation of said implant as registered in said impression material in said recess of said try-in dental restoration;
virtually planning a second model, via a computer, of a second dental restoration for said patient, comprising virtually adjusting said virtually planned first dental restoration in dependence on said scan data, the second dental restoration being an implant supported dental restoration, wherein the virtually adjusting is based on an actual implant position in the patient; and
providing second production data based on said virtually planned second model of said second dental restoration useful for production of said second dental restoration, wherein the first dental restoration in its entirety is discarded or not used upon installation of the second dental restoration in the oral cavity of said patient.

US Pat. No. 10,456,214

LIGHT POINT IDENTIFICATION METHOD

Brainlab AG, Munich (DE)...

1. A method, comprising:acquiring, from a camera system, a series of camera images of a camera viewing field;
detecting whether the series of camera images include a light mark within the camera viewing field, wherein the light mark detected represents a possible light pulse reflection;
comparing a time pattern of the light mark detected in the series of camera images to a pre-define emission pattern of light pulses; and
determining that the light mark detected is a reflected light pulse when the time pattern of the light mark detected in the series of camera images matches the pre-defined emission pattern.

US Pat. No. 10,456,213

TOMOSYNTHESIS-GUIDED BIOPSY APPARATUS AND METHOD

HOLOGIC, INC., Marlborou...

1. An apparatus comprising:a base;
a table connected to the base, wherein the table is configured to support a patient in a prone position;
an equipment support platform linearly positionable relative to the base and the table;
a tomosynthesis imaging system rotatably secured to the equipment support platform and disposed below the table for imaging a breast of the patient, wherein the tomosynthesis imaging system is rotatable about an axis substantially orthogonal to the table;
a stage arm assembly rotatably secured to the equipment support platform independent of the tomosynthesis imaging system, wherein the stage arm assembly comprises a biopsy needle configured to obtain a tissue sample from the breast of the patient imaged by the tomosynthesis imaging system; and
a breast support assembly linearly positionable along the equipment support platform, wherein the breast support assembly is configured to compress the breast of the patient.

US Pat. No. 10,456,199

DEVICE FOR FRACTIONAL LASER-BASED-TREATMENT

KONINKLIJKE PHILIPS N.V.,...

1. A treatment device for fractional laser-based skin treatment, the treatment device comprising:an emission window comprising an elongated area;
a treatment generator comprising a treatment laser, the treatment generator being configured to emit laser light towards skin tissue from a plurality of predefined locations in the emission window for generating, in use, laser-based lesions inside the skin tissue, wherein said plurality of predefined locations are disposed on a treatment axis of the emission window in said elongated area of the emission window;
a motion sensor configured to sense motion of the treatment device relative to the skin surface and to generate a motion signal representative of the sensed motion; and
a controller configured to receive the motion signal for determining a non-zero sequence of at least one of the plurality of predefined locations in the emission window from which the laser light is consecutively emitted in dependence on the motion signal, and for activating the treatment generator to generate said non-zero sequence based on a control signal representative of said non-zero sequence,
wherein the controller is configured to activate the treatment generator to generate said non-zero sequence when the sensed motion of the treatment device relative to the skin surface only has a component in a direction parallel to the treatment axis.

US Pat. No. 10,456,196

MONITORING AND TRACKING BIPOLAR ABLATION

Biosense Webster (Israel)...

1. A medical apparatus, comprising:a probe defining a longitudinal axis and having a bipolar ablation element disposed on a distal portion of the probe, the bipolar ablation element consisting of first and second ablation electrodes concentrically disposed on the distal portion of the probe relative to the longitudinal axis and a dedicated sensing electrode concentrically disposed on the distal portion of the probe relative to the longitudinal axis and between the first and second ablation electrodes, the first and second ablation electrodes being configured to operate as a bipolar pair in a bipolar mode to deliver RF energy to ablate tissue and form a lesion that extends between the first and second ablation electrodes, the dedicated sensing electrode being separate and distinct from the first and second ablation electrode and configured to sense local electrical activity in the heart when the ablation electrodes are delivering RF energy;
an ablation energy generator connected to the first and second ablation electrodes; and
a monitor connected to the sensing electrode and operative to detect cardiac electrical activity via the sensing electrode when the probe is brought into contact with a target tissue in a heart of a subject, the monitor comprising monitoring circuitry configured to track the progress of lesion formation by detecting a drop in the electrical amplitude of the electrical activity and a graphical display operative for displaying a map of a portion of the heart that includes the target tissue and a progression of energy application along an ablation path.

US Pat. No. 10,456,193

MEDICAL DEVICE WITH A BILATERAL JAW CONFIGURATION FOR NERVE STIMULATION

Ethicon LLC, Guaynabo, P...

1. A surgical instrument, comprising:a first jaw handle and a second jaw handle pivotally coupled about a joint;
the first jaw handle comprising a first jaw at a distal end of the first jaw handle;
the second jaw handle comprising a second jaw at a distal end of the second jaw handle;
the first and second jaws configured to grasp tissue therebetween when the first and second jaw handles are pivotally rotated about the joint into a closed position;
an electrical stimulation probe physically coupled to a proximal portion of either the first jaw handle or the second jaw handle and positioned physically separate from the first and second jaws such that a distal end of the electrical stimulation probe does not touch the first and the second jaws;
at least one of the first and second jaws configured to deliver therapeutic energy at a higher energy level for sealing or cutting tissue at a surgical site; and
at least one of the first and second jaws configured to deliver nontherapeutic energy at a lower energy level for providing electrical stimulation to nerve tissue at the surgical site.

US Pat. No. 10,456,189

RF GENERATOR FOR AN ELECTROSURGICAL INSTRUMENT

1. A device for generating RF power for an electrosurgical instrument, said device comprising:a controller including firmware programmed to instruct a microprocessor to generate an electrical signal having an oscillating waveform of between 200 kHz and 4 MHz and to modulate said oscillating waveform between a plurality of ON and OFF states at a frequency of between 37 Hz and 75 Hz and a duty cycle of between 90% and 98% to create discrete packets of the oscillating waveform in the plurality of the ON states;
an amplifier in communication with said oscillating waveform that amplifies said waveform to create an output electrical signal; and
an electrosurgical connector configured to receive an electrosurgical instrument and to pass said output electrical signal to said electrosurgical instrument;
wherein the oscillating waveform has a frequency in the RF spectrum and wherein the plurality of ON and OFF states creating the discrete packets has a frequency of which is less than the frequency of the oscillating waveform;
wherein the controller is configured to modulate each of the discrete packets between SUB ON and SUB OFF states to form a plurality of sub-discrete packets of the oscillating waveform; and
wherein a frequency of the SUB ON and SUB OFF states is between 3 kHz and 19 kHz with a duty cycle of between 1% and 90%.

US Pat. No. 10,456,155

TISSUE SHAVER AND METHODS OF USE

NeuroEnterprises, LLC, C...

1. A tissue shaver comprising:an outer housing including a proximal end and a distal end and a longitudinal axis disposed therebetween;
a cutting burr including a longitudinal shaft with a proximal end and a distal end, and the cutting burr on the distal end of the longitudinal shaft, the longitudinal shaft operably coupled with a plunger including a distal end and a proximal end, and the longitudinal shaft and plunger coaxially disposed within the outer housing, and the cutting burr rotates relative to the outer housing to provide a cutting action;
a first geared wheel operably coupled with the proximal end of the longitudinal shaft;
a second geared wheel rotatably coupled with the distal end of the plunger; and the second geared wheel rotatably coupled with the first geared wheel;
a spring fixedly coupled with the distal end of the plunger as to proximally bias the plunger when the plunger is translated distally; and
a handle operably coupled with the proximal end of the plunger, wherein the plunger is translated distally to along the longitudinal axis of the outer housing as to rotate the second geared wheel and rotate the cutting burr about the longitudinal axis.

US Pat. No. 10,456,150

DISCHARGE DEVICE

TERUMO KABUSHIKI KAISHA, ...

1. A discharge device comprising:an elongated flexible main body having a lumen which extends in an axial direction and configured to receive a fluid discharge substance to be discharged inside a biological organ, and a communication hole which communicates with the lumen;
a storage unit that includes a storage space which communicates with the lumen through the communication hole and configured to store the discharge substance, and a discharge section on a proximal surface of the storage unit, the discharge section configured to discharge the discharge substance stored in the storage space toward a proximal side of the main body in the axial direction, and wherein the storage unit is configured to expand and contract in response to introduction and discharge of the discharge substance, the storage unit having a substantially cylindrical shape having a predetermined length in an axial direction when being expanded; and
a hub that is provided in a proximal portion of the main body, and wherein the hub is configured to be connected to and separated from a supply device for supplying the discharge substance.

US Pat. No. 10,456,149

APPARATUS AND METHOD TO ACCESS BONE MARROW

1. An apparatus comprising:a penetrator assembly including an outer penetrator and an inner trocar, the outer penetrator having a flange configured to stabilize the penetrator assembly against an insertion site on skin of a patient and a cannula fixedly extending from the flange, the cannula operable to be inserted into bone marrow, and the inner trocar operable to penetrate bone marrow; and
a right angle connector removably couplable to the outer penetrator and operable to couple the outer penetrator to a source of intravenous fluid;
wherein the cannula of the outer penetrator is configured to removably receive a portion of the inner trocar, and
wherein the inner trocar includes a receptacle configured to receive a penetrator assembly connector to connect the penetrator assembly to a powered drill, the receptacle including a release mechanism configured to releasably attach the penetrator assembly to the penetrator assembly connector.

US Pat. No. 10,456,137

STAPLE FORMATION DETECTION MECHANISMS

Ethicon LLC, Guaynabo, P...

1. A medical instrument, comprising:an elongated channel configured to support a staple cartridge, the staple cartridge comprising a plurality of staples;
an anvil mechanically coupled to the elongated channel, wherein the anvil defines first and second staple-forming pockets;
a first electrically conductive circuit element positioned within the first staple-forming pocket, wherein the first electrically conductive circuit element comprises:
a first electrically insulative material positioned on a surface of the first staple-forming pocket;
an electrically conductive material positioned on the first electrically insulative material; and
a second electrically insulative material positioned on the electrically conductive material;
a second electrically conductive circuit element positioned within the second staple-forming pocket; and
a control circuit electrically coupled to the first and second electrically conductive circuit elements, wherein the control circuit is configured to:
determine a state of the first electrically conductive element, wherein the state of the first electrically conductive element corresponds to severance of the first electrically conductive element;
determine a state of the second electrically conductive element, wherein the state of the second electrically conductive element corresponds to severance of the second electrically conductive element; and
determine a formation characteristic of one of the plurality of staples based on the state of the first electrically conductive element and the state of the second electrically conductive elements.

US Pat. No. 10,456,133

MOTORIZED SURGICAL INSTRUMENT

Ethicon LLC, Guaynabo, P...

1. A surgical instrument, comprising:an end effector comprising a firing element;
a motor mechanically coupled to the firing element;
a power source; and
a control system electrically coupled to the motor and the power source, wherein the control system comprises:
a sensing device configured to sense a position of the firing element;
a control circuit electrically coupled to the sensing device;
a switching device controlled by the control circuit; and
a resistive element electrically connected in parallel with the switching device,
and wherein the control system is configured to modulate power applied to the motor based on the following:
the sensed position of the firing element; and
a direction of travel of the firing element.

US Pat. No. 10,456,132

JAW OPENING FEATURE FOR SURGICAL STAPLER

Ethicon LLC, Guaynabo, P...

1. A surgical stapler comprising:(a) an end effector, wherein the end effector comprises:
(i) a lower jaw comprising:
(A) a cartridge body housing a plurality of staples, and
(B) a cartridge tray comprising a bottom surface, a first side wall, a second side wall, and a resilient member comprising a base portion and an arm portion connected at a junction, wherein the junction is located at a proximal end on the first side wall, wherein the arm portion extends upwardly from the junction, wherein the cartridge tray is configured to house a portion of the cartridge body, and
(ii) an anvil pivotable relative to the lower jaw between an opened position and a closed position, wherein the arm portion of the resilient member is positioned and configured to contact the anvil in both the opened position and the closed position,
wherein the resilient member is configured to bias the anvil to remain in the opened position when the anvil is in the opened position; and
(b) a body assembly, wherein the end effector is positioned distally relative to the body assembly.

US Pat. No. 10,456,114

METHOD AND ULTRASOUND APPARATUS FOR DISPLAYING DIFFUSION BOUNDARY OF MEDICINE

Samsung Medison Co., Ltd....

1. A method of marking a diffusion boundary of medicine, the method performed by an ultrasound apparatus and comprising:obtaining first B mode image data and first Doppler data about a target object to which the medicine is injected;
obtaining second Doppler data about the target object, after the first B mode image data and the first Doppler data are obtained and then a preset time elapses;
detecting a first area of the target object from which the first Doppler data is obtained and a second area from which the second Doppler data is obtained;
determining a first diffusion boundary of the medicine, based on the first area, and determining a second diffusion boundary of the medicine, based on the second area;
marking the first diffusion boundary of the medicine and the second diffusion boundary of the medicine on a B mode image that is generated by using the first B mode image data; and
displaying, on the B mode image, comparison data obtained by comparing an estimated diffusion range of the medicine with an actual diffusion range of the medicine,
wherein the comparison data comprises:
estimating the diffusion range of the medicine, based on at least one of information about a position to which the medicine is injected and an injection amount of the medicine,
obtaining the actual diffusion range of the medicine, based on the first area and the second area, and
comparing the estimated diffusion range of the medicine with the actual diffusion range of the medicine, and
the method further comprises displaying the comparison data including an error rate of the estimated diffusion range of the medicine for the actual diffusion range of the medicine.

US Pat. No. 10,456,110

ULTRASOUND IMAGING APPARATUS

HITACHI, LTD., Tokyo (JP...

1. An ultrasound imaging apparatus comprising:an ultrasonic element array having a plurality of ultrasonic elements arrayed along a predetermined direction, the plurality of ultrasonic elements transmitting ultrasonic waves to an imaging area of a test object and receiving ultrasonic waves reflected off the test object;
a transmission beam former, comprising a transmission scanning line control unit, that sequentially transmits signals causing transmission beams to be transmitted from the ultrasonic element array along a plurality of transmission scanning lines set in the imaging area of the test object;
a reception beam former, comprising a delay addition calculating unit, that sets a plurality of reception scanning lines for each of the transmission beams and generates signals, the signals being generated by phasing and adding received outputs of the ultrasonic elements via the delay addition calculating unit, at a plurality of received focal points on the respective reception scanning lines;
a beam memory, which stores a plurality of phase outputs corresponding to each of the plurality of reception scanning lines generated by the reception beam former;
an aperture synthesizing unit that adds a plurality of phase outputs obtained from reflected ultrasonic waves of the transmission beams, including the stored plurality of phase outputs from the beam memory, which are different, at the received focal points, which are the same;
a frame memory which stores a phase output generated by the aperture synthesizing unit;
an image processing unit which reads the phase output stored on the frame memory and generates an image of the imaging area;
an image display unit which displays the generated image;
a receiving unit that receives an instruction to perform a high speed imaging mode from an operator;
a transmission/reception switching unit which transmits the signals from the transmission beam former to the ultrasonic element array and receives signals from the ultrasonic element array; and
a control unit,
wherein when the receiving unit receives an instruction to perform a high speed imaging mode, the transmission scanning line control unit determines intervals, corresponding to speed in the high speed imaging mode, between the plurality of transmission scanning lines, and the transmission beam former sequentially transmits the signals causing the transmission beams to be transmitted along the plurality of transmission scanning lines at the determined intervals corresponding to imaging speed in the high speed imaging mode;
the aperture synthesizing unit sets a number of the phase outputs to be added at each of the received focal points to a predetermined addition number (N) reducing occurrence of stripes on the image; and
in order to generate the addition number (N) of the phase outputs at each of the received focal points, the control unit finds a number (M) of the reception scanning lines, the number (M) set by the reception beam former, and the control unit notifies the reception beam former of the found number (M) of the reception scanning lines.

US Pat. No. 10,456,107

ULTRASOUND IMAGING DEVICE AND METHOD FOR TRANSMITTING AUDIBLE SOUNDS

GENERAL ELECTRIC COMPANY,...

1. An ultrasound imaging system comprising:a probe comprising a plurality of elements; and
an ultrasound imaging device comprising:
an exterior housing comprising a panel;
a processor positioned within the exterior housing; and
an acoustic emitter attached to the panel and electrically connected to the processor;
wherein the processor is configured to control the acoustic emitter to vibrate the panel and transmit audible sounds, using the panel as a sound-excited assembly; and
wherein the processor is configured to control the plurality of elements in the probe to emit ultrasonic signals.

US Pat. No. 10,456,091

DISPLAYS FOR A MEDICAL DEVICE

Abbott Diabetes Care Inc....

1. A system, comprising:an analyte sensor for positioning in fluid contact with bodily fluid under a skin surface to measure an analyte level, the analyte sensor having a predetermined sensor life; and
a receiving device including a display and an alarm component, the receiving device configured to:
receive signals corresponding to the measured analyte level;
operate in a first mode to provide an alarm using the alarm component when the measured analyte level differs more than a predetermined level from an analyte threshold;
determine that the predetermined sensor life of the analyte sensor has elapsed;
operate in a second mode wherein the alarm component is deactivated; and
provide a message on the display to inform a user that the alarm component is deactivated.

US Pat. No. 10,456,089

PATIENT MONITORING FOR SUB-ACUTE PATIENTS BASED ON ACTIVITY STATE AND POSTURE

KONINKLIJKE PHILIPS N.V.,...

1. A medical system comprising:at least one sensor configured to measure at least one of an activity state and a posture of a patient;
at least one vital sign sensor separate from the at least one sensor and configured to measure one or more vital signs of the patient according to a schedule wherein the one or more vital signs comprise one or more of pulse, oxygen saturation (SpO2), respiration, temperature, and carbon dioxide;
at least one processor programmed to:
adjust the schedule when the measured one or more vital signs is outside of a vital sign threshold;
control the at least one vital sign sensor to measure the at least one vital sign according to the adjusted schedule including delaying a scheduled measurement until the activity state indicates a resting state that is below the position threshold;
generate a patient deterioration alert when (i) the measured at least one of activity state and posture of the patient and (ii) the measured one or more vital signs are each outside of respective alarm thresholds; and
output the patient deterioration alert to an audio device.

US Pat. No. 10,456,085

METHOD AND DEVICE FOR MEASURING A BIOLOGICAL SIGNAL

SAMSUNG ELECTRONICS CO., ...

1. A method of measuring a biological variable, the method comprising:irradiating an infrared signal toward a body part;
detecting an infrared signal of the irradiated infrared signal which is reflected from the body part;
extracting spectrum data from the detected infrared signal;
obtaining intensity data corresponding to a first frequency range and a second frequency range from the extracted spectrum data by using an Incremental Association Markov Blanket (IAMB) algorithm, wherein the first frequency range includes a first preset frequency, and the second frequency range includes a second preset frequency being higher than the first preset frequency;
obtaining a biological information-measuring model by performing multiple linear regression (MLR) on the obtained intensity data; and
measuring the biological variable of the body part by using the obtained biological information-measuring model.

US Pat. No. 10,456,071

SYSTEM AND METHOD FOR ESTIMATING COGNITIVE TRAITS

Tata Consultancy Services...

1. A method for estimating or improvising perceptual-cognitive traits of a subject, the method being implemented by at least one processor and comprising:retrieving and pre-processing data and associated metadata indicative of brainwave activity of the subject to obtain effect of a plurality of elementary cognitive tasks, wherein the data comprises electroencephalogram (EEG) signals, and wherein processed EEG signals are analyzed by:
partitioning the processed EEG signals into plurality of baseline and trial epochs;
analyzing the baseline and trial epochs in a time frequency domain using an S-transform, and
computing mean frequencies of the baseline and trial epochs to derive peak and average power shifts and corresponding frequency shifts thereof, and
concatenating the peak powers and peak frequency shifts or average powers and average frequency shifts or a combination thereof to determine characterizing feature vectors between the baseline and trial epochs obtained from different frequency bands;
identifying cognitive categories within a cognitive domain of a cognitive learning model;
mapping a plurality of elementary cognitive tasks to be performed by the subject with identified cognitive categories;
performing cluster analysis on each of the mapped elementary cognitive tasks and determining separation index values using the cluster analysis in relation to the identified cognitive categories; and
generating metrics from the separation index values for estimation or improvisation of perceptual-cognitive traits of the subject.

US Pat. No. 10,456,068

DEVICE FOR OBTAINING SMALL, PRECISE VOLUMES OF FLUID FROM ANIMALS

Med-Ag Industries, Inc., ...

1. A device for obtaining a small volume fluid sample from an animal, the device comprisinga handle for one-handed operation by a user; and
a fluid extraction device disposed at a first end of the handle, the fluid extraction device comprising
a fluid extraction component disposed at an end termination of the fluid extraction device; and
a fluid collection component removably attached to the fluid extraction component, the fluid collection component comprising a pipette disposed in fluid communication with the fluid extraction component for receiving the small volume fluid sample through capillary action.

US Pat. No. 10,456,067

BLOOD COLLECTION ASSEMBLY

Becton, Dickinson and Com...

1. A blood collection assembly, comprising:a holder housing defining a receiving chamber and including a rearward end adapted to receive a sample collection tube within the chamber, a forward end including a receiving port having an interior surface, and a receiving structure formed within the interior surface of the receiving port, the receiving structure comprising a radial receiving portion comprising an annular groove extending perimetrically within the interior surface of the receiving port and dividing the interior surface into a first portion and a second portion and a longitudinal receiving portion; and
a hub comprising a hub outer surface extending between a distal end and a proximal end, the hub further comprising an internal opening extending therethrough and a puncturing element at the proximal end thereof;
wherein the hub outer surface comprises a radial locking component and an anti-rotation member, the radial locking component comprising an annular protrusion extending perimetrically about the hub outer surface and dividing the outer surface of the hub into a first portion and a second portion and the anti-rotation member protruding from and extending longitudinally along the hub outer surface perpendicular to the radial locking component,
wherein a first portion of the anti-rotation member extends from the first portion of the outer surface of the hub on one side of the annular protrusion in a longitudinal direction towards the distal end of the hub and a second portion of the anti-rotation member extends from the second portion of the outer surface of the hub on an opposite side of the annular protrusion in a longitudinal direction towards the proximal end of the hub, the annular protrusion intersecting the anti-rotation member,
wherein upon receipt of the anti-rotation member within the receiving port, the anti-rotation member and the longitudinal receiving portion are adapted to align the hub and the holder housing in a predetermined position with respect to one another and are adapted to prevent rotational movement of the hub within the receiving port;
wherein, with the hub received within the receiving port of the holder housing, the radial locking component lockably engages the radial receiving portion and the anti-rotation member engages the longitudinal receiving portion thereby providing a snap-fit engagement for axially locking the hub to the holder housing with the puncturing element of the hub extending through the receiving port and into the chamber of the holder housing, and
wherein the first portion of the interior surface of the receiving port contacts the first portion of the outer surface of the hub and the second portion of the interior surface of the receiving port contacts the second portion of the outer surface of the hub.

US Pat. No. 10,456,064

SUBCUTANEOUS SENSOR INSERTER AND METHOD

1. A continuous analyte monitoring inserter apparatus for subcutaneous placement of a sensor into skin of a patient that minimizes pain to a patient, the apparatus comprising:a single action inserter assembly having a housing body with a first body end and a second body end, a deployment button partially disposed and slidable within the housing body through the first body end, the deployment button being movable between a first position and a second position, and a sensor housing partially disposed within and removably retained in the second body end;
a needle having a cross-sectional shape that minimizes a peak force of insertion into the skin of the patient, the needle having an insertion angle that further minimizes the peak force of insertion into the skin of the patient, wherein the needle is movably disposed within the single action inserter assembly, the implantable sensor having sidewalls which frictionally engage an inside surface portion of the needle;
a deployment mechanism that contains a sensor deployment assembly and the needle wherein the deployment mechanism is contained within the deployment button; and
an implantable sensor partially disposed within the needle and the sensor deployment assembly, wherein the implantable sensor comprises a loop configured to secure the implantable sensor in the sensor deployment assembly;
wherein the inserter assembly is adapted to substantially simultaneously implant the sensor subcutaneously into the patient, retract the needle, fix the sensor and the sensor deployment assembly within the sensor housing and release the inserter assembly from the sensor housing with a single activation of the deployment button caused by moving the deployment button from the first position to the second position while minimizing pain to the patient.

US Pat. No. 10,456,063

SYSTEM AND METHOD FOR MONITORING PLEURAL FLUID

Board of Regents of the U...

1. A system for monitoring pleural fluid, comprising:at least one detection unit configured to receive fluid from a pleural cavity of a patient, detect carbon dioxide present in the fluid, and detect a second substance present in the fluid;
at least one processing unit in communication with the at least one detection unit, the at least one processing unit configured to provide a first electrical signal when the at least one detection unit detects carbon dioxide, and provide a second electrical signal when the at least one detection unit detects the second substance; and
an adaptor fluidically coupled to a chest tube, the adaptor comprising a first path configured to direct a gaseous portion of fluid received from the chest tube along a detection path to the at least one detection unit, and a second path configured to direct at least a liquid portion of the fluid received from the chest tube along a drainage path to a fluidically coupled drainage canister.

US Pat. No. 10,456,061

HOLDING ARRANGEMENT FOR A SURGICAL ACCESS SYSTEM

Nico Corporation, Indian...

7. A holding arrangement for a surgical access assembly comprising:a holder member,
a support member selectively engageable with the holder member,
wherein at least the support member is compatible with a magnetic resonance imaging device;
wherein the holder member further comprises:
one or more legs, each of the one or more legs having a base, a neck portion, and a pair of jaws that are selectively moveable with respect each other, wherein the one or more legs, each base of the one or more legs, the neck portion, and/or the pair of jaws are malleable, and wherein each base is malleable to conform to a non-linear surface and comprises a base opening so that the holder member is attachable to the non-linear surface; and
wherein the jaws are parallel to each other and define a channel, wherein the channel serves as a stop to retain the support member within a notch that is in communication with the channel.

US Pat. No. 10,456,059

NEUOROLOGICAL CONDITION DETECTION UNIT AND METHOD OF USING THE SAME

Forest Devices, Inc., Pi...

1. A method for detecting a neurological condition comprising:attaching evoked electrodes on opposite sides of a body so that a first evoked electrode is positioned on a left side of the body and a second evoked electrode is positioned on a right side of the body at a position that corresponds to where the first evoked electrode is positioned on the left side of the body;
positioning sensors on the opposite sides of the body via headgear to simultaneously position the sensors on the body to detect brain reaction to electrical current passed into the body for a pre-selected number of shocks,
communicatively connecting the evoked electrodes and the sensors to a computer device having non-transitory memory connected to a processor;
positioning a reference sensor on the body so that the reference sensor is located on a central region of a forehead at a location that is between a first sensor of the sensors that is positioned on a left side of a head of the body and a second sensor of the sensors that is positioned on a right side of the head of the body; and
the computer device utilizing the reference sensor to determine that at least one of the sensors needs to be re-positioned so that the sensors on opposite sides of the body have a pre-selected orientation;
the computer device determining that at least one of the sensors needs to be re-positioned so that the sensors on opposite sides of the body have the pre-selected orientation and outputting an orientation warning to indicate at least one of the sensors needs to be repositioned for sensor orientation for repositioning at least one of the sensors on the body;
after the at least one of the sensors is repositioned for sensor orientation based on the orientation warning output by the computer device, shocking the body via the evoked electrodes for the pre-selected number of shocks within a pre-selected time period, the computer device transmitting the electrical current to the evoked electrodes for the shocking of the body via the evoked electrodes, wherein the shocking of the body via the evoked electrodes for the pre-selected number of shocks within the pre-selected time period comprises passing an electrical current into the body via an electricity transmitter of the computer device that is connected to the evoked electrodes;
the sensors positioned on the opposite sides of the body detecting data from the body as the body responds to the pre-selected number of shocks;
the computer device receiving the detected data from the sensors;
the computer device generating at least one of wave forms and curves that identify morphological features for responses from the pre-selected number of shocks that the opposite sides of the body are measured to have based on the detected data received from the sensors;
the computer device comparing the morphological features to determine a difference between a morphological feature for the left side of the body and a morphological feature for the right side of the body that is at or exceeds a pre-selected threshold that is defined to indicate the left side of the body has a different somatosensory evoked potential responding to the shocks as compared to the right side of the body responding to the shocks for indication of a neurological condition requiring treatment, the neurological condition requiring treatment being a stroke; and
the computer device generating a notification to identify a detection of the neurological condition in response to a result of the comparing of the morphological features indicating that the difference between the morphological feature for the left side of the body and the morphological feature for the right side of the body is at or exceeds the pre-selected threshold so that the neurological condition is identifiable prior to transporting the body to a care facility.

US Pat. No. 10,456,055

DEVICE FOR APPLYING ELECTRODE ASSEMBLIES

1. An apparatus with a plurality of electrode assemblies (10) which can be applied to the surface of the skin (4) of an animal or a human being, by which electrode assemblies voltages and currents can be picked up from the skin surface (4), which apparatus further has a flexible, extendable, retaining element (6) which is formed with a flat or film-like molded piece, whereineach electrode assembly of the plurality of electrode assemblies (10) has a main body (1) and a plurality of pin electrodes (2) which project in the same direction from the main body (1) and are arranged on a common ring (14),
the plurality of electrode assemblies (10) are attached to the retaining element (6), and
the main body (1) of each electrode assembly (10) is connected to the retaining element (6), and the plurality of pin electrodes (2) of all of the plurality of electrode assemblies (10) project in the same direction, wherein a through-going recess (3) is provided in the main body (1) of of each electrode assembly, through which recess a gel (5) can be applied to the skin surface (4) when the plurality of pin electrodes (2) are applied against the skin surface (4), which gel reduces the contact resistance between the skin surface (4) and the plurality of pin electrodes (2).

US Pat. No. 10,456,050

FERROELECTRIC COMPOSITE MATERIAL-BASED ARTIFICIAL ELECTRONIC SKIN

UNIST (ULSAN NATIONAL INS...

1. An artificial electronic skin comprising: a lower electrode; a first layer laminated on the lower electrode; a hemispherical first micro dome formed on the first layer to stand upright; a second layer laminated on the first layer; a hemispherical second micro dome formed on a lower portion of the second layer which faces the first layer to be interlocked with the first micro dome; an upper electrode laminated on an upper end surface of the second layer; and a pattern layer laminated on an upper end surface of the upper electrode and configured to receive an external pressure applied thereto.

US Pat. No. 10,456,047

METHOD AND SYSTEM FOR MONITORING HEMODYNAMICS

Cheetah Medical, Inc., W...

1. A system for monitoring hemodynamics of a subject, comprising:medical leads connectable to an organ at a first part of the body of the subject, and to an organ at a second part of the body of the subject;
a signal generating system configured for providing at least a first output electric signal and a second output electric signal, and transmitting, via said medical leads, said first output signal to said organ at said first part of the body of the subject and said second output signal to said organ at said second part of the body of the subject;
a demodulation system configured for receiving via said medical leads a first input electrical signal sensed from said first part of the body and a second input electrical signal sensed from said second part of the body, and for demodulating each input electrical signal to provide an in-phase component and a quadrature component of each input signal;
a signal processing system having a circuit for combining in-phase components of said first and said second input signals to provide a first hybrid signal, for combining quadrature components of said first and said second input signals to provide a second hybrid signal, and for generating on a display device a graphical output co-displaying said hybrid signals.

US Pat. No. 10,456,041

MEDICAL IMAGING APPARATUS AND METHOD OF CONTROLLING THE SAME

SAMSUNG ELECTRONICS CO., ...

1. A medical imaging apparatus, comprising:at least one processor configured to register a pre-imaged medical image with respect to an object based on a first reference point included in the pre-imaged medical image and a second reference point of the object;
a location detector configured to detect movement of a user based on the second reference point; and
a user interface configured to display an image of the pre-imaged medical image that corresponds to the detected movement of the user,
wherein the at least one processor is further configured to recognize the second reference point by detecting a marker on a diagnostic device when the pre-imaged medical image is displayed.

US Pat. No. 10,456,040

IMAGING DEVICE

SHIMADZU CORPORATION, Ky...

1. An imaging device, comprising:an excitation light source that irradiates an excitation light to a subject;
wherein the excitation light excites a fluorophore administered into said subject to produce a fluorescence;
a visible light source that irradiates a visible light to said subject;
a camera capable of detecting the fluorescence and the visible light;
wherein said fluorescence is emitted from said fluorophore due to said irradiation of the excitation light and said visible light is reflected from a surface of said subject; and
an image fusion element that generates a fused image by combining a visible image of the subject and a fluorescent image of the subject imaged by the camera; and
wherein said image fusion element generates a first corrected image by modifying a pixel value of an area of said fluorescent image relative to said visible image using said visible image and said fluorescent image, generates a second corrected image by coloring said fluorescent image and combining said first corrected image and said second corrected image.

US Pat. No. 10,456,032

OPHTHALMIC IMAGING APPARATUS AND OPHTHALMIC IMAGE PROCESSING APPARATUS

TOPCON CORPORATION, Itab...

1. An ophthalmic imaging apparatus comprising:an optical coherence tomography (OCT) data acquisition unit configured to acquire a three dimensional data set of a fundus of a subject's eye; and
a processor comprising:
a blood vessel enhanced image forming unit configured to form a blood vessel enhanced image based on the three dimensional data set;
a blood vessel gradient distribution determination unit configured to determine a blood vessel gradient distribution that shows gradients of blood vessels at a plurality of locations in the fundus, based on the blood vessel enhanced image; and
a location determination unit configured to determine one or more locations in the fundus where gradients satisfy a predetermined condition, based on the blood vessel gradient distribution,
wherein
the predetermined condition includes chronological gradient variation information for making a diagnosis, and
the location determination unit determines the one or more locations based on two or more blood vessel gradient distributions of the fundus obtained on different dates and the chronological gradient variation information.

US Pat. No. 10,456,031

SYSTEMS, METHODS, AND DEVICES FOR OPTICAL COHERENCE TOMOGRAPHY MULTIPLE ENFACE ANGIOGRAPHY AVERAGING

Doheny Eye Institute, Lo...

1. A system for obtaining and processing images of a biological material, the system comprising:one or more computer readable storage devices configured to store a plurality of computer executable instructions; and
one or more hardware computer processors in communication with the one or more computer readable storage devices and configured to execute the plurality of computer executable instructions in order to cause the system to:
access or obtain a plurality of Optical Coherence Tomography (OCT) images generated from an OCT scanner;
generate, from the plurality of OCT images, a plurality of enface images of one or more superficial layers of the biological material and a plurality of enface images of one or more deep layers;
divide each of the plurality of enface images of the one or more superficial layers and each of the plurality of enface images of the one or more deep layers into a plurality of sectors;
apply one or more image registration techniques to each of the plurality of sectors of each of the plurality of enface images of the one or more superficial layers to generate one or more image alignment settings;
generate an averaged enface image of each of the one or more deep layers by applying one or more image registration techniques, based at least in part on the one or more generated image alignment settings, to each of the plurality of sectors of each of the plurality of enface images of the one or more deep layers; and
transmit the one or more averaged enface images for causing display of the one or more averaged enface images by an output device.

US Pat. No. 10,456,012

DISPOSABLE ENDOSCOPE AND SYSTEM

Tao Dong, Shenzhen, Guan...

1. A disposable endoscope comprising:a tubular part including a plurality of joints;
linear transmission parts inserted into the tubular part, wherein one end of each linear transmission part is fixed with respect to one of the joints, the other end of each linear transmission part is provided with a respective one of first connectors, a movement of the linear transmission part along its length direction is able to cause the tubular part to bend, and each first connector is used to detachably engage with a corresponding connector of an external control seat;
a camera unit mounted on a front end of the tubular part and connected with an external power supply and a data processing device to provide the camera unit with power and transmit image data collected;
a cladding layer cladding the tubular part and the linear transmission parts;
a connection head arranged at one end of the linear transmission parts away from the tubular part, wherein the connection head is provided with through holes through which the first connectors pass; and
a disposable fastener which is used to fix the first connectors with respect to the connection head, wherein after the disposable fastener is removed, each first connector is able to be moved in a respective through hole of the connection head along their length direction.

US Pat. No. 10,456,007

CONVEYOR DISHWASHER AND METHOD FOR OPERATING A CONVEYOR DISHWASHER

ILLINOIS TOOL WORKS INC.,...

1. A conveyor dishwasher having a conveying apparatus for conveying washware through individual treatment zones of the conveyor dishwasher, wherein the conveyor dishwasher has at least one wash zone in which wash liquid from a wash tank which is associated with the at least one wash zone is sprayed onto the washware, wherein the conveyor dishwasher further has at least one final rinse zone which is arranged downstream of the at least one wash zone as seen in a conveying direction of the washware and in which final rinse liquid is sprayed onto the washware, and wherein the conveyor dishwasher further has a waste air system for discharging waste air from the conveyor dishwasher,characterized
in that a waste water heat recovery system is provided for transferring at least a portion of the thermal energy in the waste water from the conveyor dishwasher as heat to the final rinse liquid which is to be sprayed in the at least one final rinse zone, and
in that a waste air heat recovery system is further provided for transferring at least a portion of the thermal energy in the waste air which is discharged or is to be discharged from the conveyor dishwasher as heat to at least the final rinse liquid which is to be sprayed in the at least one final rinse zone.

US Pat. No. 10,456,000

SURFACE CLEANING HEAD WITH A VALVE ASSEMBLY

Techtronic Industries Co....

1. A surface cleaning head for a surface cleaning apparatus comprising:a dirty air inlet;
a dirty air outlet;
a dirty airflow path extending between the dirty air inlet and the dirty air outlet; and
an automated valve assembly operable to open and place the dirty airflow path in fluid communication with ambient pressure,
wherein the automated valve assembly is adjustably opened based upon a suction level within the dirty airflow path,
wherein the automated valve assembly includes a plurality of valves positioned between the dirty airflow path and ambient pressure operable to sequentially open as the suction within the dirty airflow path increases.

US Pat. No. 10,455,998

VACUUM CLEANER

SAMSUNG ELECTRONICS CO., ...

1. A vacuum cleaner comprising:a main body;
a dust collector arranged in the main body to collect dust from air that flows into the main body along an intake passage; and
a suction device arranged at a downstream that is lower than a location of the dust collector on the intake passage to provide a suction force,
wherein the suction device includes:
a suction force generator,
a first housing configured to accommodate the suction force generator, and including a first discharge hole provided in a bottom surface of the first housing and discharging the air sucked from the suction force generator to an outside,
a second housing configured to accommodate the first housing, and including a second discharge hole provided in a side surface of the second housing and discharging the air that flows in from the first discharge hole to the outside,
a third housing provided separately from the main body and configured to accommodate the second housing, and including a third discharge hole provided in a side surface of the third housing and discharging the air that flows in from the second discharge hole to the outside,
a first sound absorbing member arranged in the bottom surface of the first housing, and
a second sound absorbing member arranged between the side surface of the first housing and the side surface of the second housing, wherein the second sound absorbing member is in contact with an outer surface of the first housing and an inner surface of the second housing.

US Pat. No. 10,455,984

CONTAINER

TRI Innovations LLC, Hal...

1. A container, comprising:an upper grinding section, a lower grinding section, a collection section, an electronics housing, a storage container section, and a container holder;
the upper and lower grinding sections are mated together and are configured to grind and pulverize a target material;
the collection section is disposed beneath the lower grinding section and collects material falling through holes in the lower grinding section;
the electronics housing includes a display, microcontroller, and a power source; and
the storage container section is disposed beneath the electronics housing and is retained by the container holder.

US Pat. No. 10,455,983

MODULAR FOOD HOLDING SYSTEM

PRINCE CASTLE LLC, Carol...

1. A modular food holding system comprising:a plurality of individual modularized food holding chambers, each of the plurality of food holding chambers being physically and communicatively removably connected to one another, each of the food holding chambers comprising a food holding cavity and at least one of a heating element and a cooling element for heating or cooling the food holding cavity;
a chamber base physically and communicatively removably connected to one of the food holding chambers in the plurality of food holding chambers;
a food pan removably inserted within the food holding cavity of a food holding chamber of the plurality of individual modularized food holding chambers; and
a smart sensor either (i) integral to or (ii) physically attached to an exterior part of the food pan and operatively coupled to an electrical component of the food holding chamber of the plurality of individual modularized food holding chambers, wherein the smart sensor is in fluid connection with an interior of the food pan and directly senses a characteristic of a food holding environment within the food holding chamber.

US Pat. No. 10,455,981

COMBUSTION BOX

1. A combustion box comprising: an inner casing (1) with a tubular configuration defining a hollow therein, which is disposed in a volumetric housing (2), wherein the inner casing (1) extends through the inside of the volumetric housing (2), and each one of the ends (11, 12) of the inner casing (1) is in contact with one of opposite faces (21, 22) of the inner contour of the volumetric housing (2), wherein an inner intermediate space (3) is defined between the inner contour of the volumetric housing (2) and the inner casing (1), and the intermediate space (3) contains a flammable solid material (5), wherein an outer support (6) is removably disposed within the inner casing in a non-use configuration, further comprising two essentially horizontal sheets (31), the inner casing (1) separating and passing through the same, inside the housing (2) and are adjusted on the inner contour of the volumetric housing (2).

US Pat. No. 10,455,979

SMOKE TRAP APPARATUS AND SYSTEM

Traeger Pellet Grills, LL...

1. A device for at least one of grilling and smoking food products, comprising:an oven section having an outer wall and a lid that at least partially enclose an internal grilling compartment;
at least one rack for supporting food products within the internal grilling compartment; and
a grease management system, comprising:
a drip tray disposed below the at least one rack within the internal grilling compartment;
a receptacle having a floor and a perimeter wall extending upward from the floor, the floor and perimeter wall of the receptacle forming a receptacle cavity into which grease falling onto the drip tray is directed, the floor of the receptacle having a drain opening;
a tubular riser comprising a side wall surrounding the drain opening and extending upward from the floor of the receptacle into the receptacle cavity, an upper end of the tubular riser including an opening to an interior of the tubular riser, the opening positioned within the receptacle cavity and in fluid communication with the drain opening in the floor of the receptacle such that grease or liquid within the receptacle cavity can flow into the tubular riser through the opening and out from the receptacle cavity through the drain opening in the floor of the receptacle upon reaching a depth within the receptacle cavity; and
a capping element having an upper wall and a side wall extending downward from the upper wall, the capping element positioned over the tubular riser and configured such that grease or liquid within the receptacle cavity can flow under the upper wall of the capping element and into the tubular riser, the capping element further configured such that a quantity of grease or liquid within the receptacle cavity would preclude smoke within the oven section from flowing out from the oven section through the tubular riser.

US Pat. No. 10,455,971

AUTOMATIC MACHINE FOR PREPARING COFFEE

1. An automatic machine for preparing coffee, comprising an infusion assembly, a water tank, a heat exchanger with associated pump, and a grinder for grinding coffee beans, wherein said grinder is arranged in line with said infusion assembly and horizontally with respect to a resting surface of the machine, a container adapted to contain coffee beans being connected, in an upper region, to said grinder, said grinder being connected to a chamber adapted to contain a scraper, the ground coffee being adapted to pass horizontally from said grinder to said scraper, in order to accommodate within said scraper a preset dose of ground coffee, wherein said scraper is adapted to rotate within said chamber, said chamber being defined by a lower portion and an upper portion of said infusion assembly, which are mutually pivoted and/or coupled.

US Pat. No. 10,455,970

PACK, SYSTEM AND METHOD FOR PREPARING BEVERAGES

Societe des Produits Nest...

1. A pack with an inner volume in which a food or beverage ingredient is stored and in which a beverage is produced when water is introduced inside,the inner volume being defined by sheets of material joined at edges thereof, and the inner volume having a generally plane shape defining a plane vertically oriented during beverage production,
the pack comprising at least one water inlet configured for introducing the water in the inner volume and at least one beverage outlet configured for delivering the beverage from the inner volume, the at least one water inlet and the at least one beverage outlet being included in a single insert, the single insert being positioned at a bottom of the pack and being partially positioned between joined bottom edges of the sheets of material, and
an external end of the at least one water inlet is oriented essentially perpendicularly to the plane defined by the inner volume, and
the single insert comprises a centring hole extending essentially perpendicularly to the generally plane shape of the inner volume.

US Pat. No. 10,455,959

PORTABLE BEVERAGE CONTAINER WITH A ROBUST AND EASILY CLEANABLE SEAL MECHANISM

IGNITE USA, LLC, Chicago...

1. A lid assembly for use with a portable beverage container, comprising:a lid housing;
a spout coupled to the lid housing and movable between a stowed configuration and a dispensing configuration, the spout defining a fluid passageway;
a seal housing carrying a sealing element, the seal housing is movable between an in-use position, wherein the seal housing is coupled to the lid housing and engages the spout such that the sealing element controls fluid flow through the fluid passageway of the spout, and a cleaning position, wherein the seal housing is coupled to the lid housing and spaced from the spout to permit cleaning of the sealing element;
a support base coupled to the lid housing and the seal housing;
a biasing element coupled to a portion of the support base, the biasing element configured to bias the seal housing to the cleaning position; and
a support arm connecting the seal housing and the support base, the biasing element coupled to a portion of the support arm.

US Pat. No. 10,455,957

HEALTH PILLOW

1. A health pillow comprising a supine portion and two side-lying portions symmetrically arranged on the two opposite sides of the supine portion, wherein each of the side-lying portions has a front surface, the supine portion has a supporting protrusion extending beyond the front surfaces, and the supporting protrusion has a length between 6 cm and 20 cm and has a flat surface extending outwardly and away from the front surfaces, wherein the supporting protrusion has a front end away from the front surfaces which is formed with a tip structure having an inclined surface, and wherein the supine portion has a head-receiving recess disposed at a height lower than that of the flat surface and the front end of the supporting protrusion.

US Pat. No. 10,455,955

WALL MOUNTED STORAGE DEVICE WITH INTEGRATED HINGE

Steel Wave Ventures, LLC,...

1. A storage device with an integrated hinge coupleable to a structure, comprising:a mounting plate;
an external plate coupled to the mounting plate to define a receiving cavity, said external plate having a lower portion, an upper portion, and an intermediate portion, said intermediate portion extending outwardly at a non-zero angle with respect to an outer surface of the lower portion; and
a hinge plate received in the receiving cavity and coupled to the external plate, the hinge plate pivotably moveable about a pivot axis between an open position and a closed position, the hinge plate including a receiving portion at a lower end of the hinge plate and a securing portion at an upper end of the hinge plate, the receiving portion of the hinge plate being configured to receive and support an object when the object is positioned within the receiving cavity, and the securing portion being configured to move toward the mounting plate to secure the object between the securing portion and the mounting plate as the hinge plate moves from the open position to the closed position in response to the object engaging the receiving portion of the hinge plate.

US Pat. No. 10,455,954

SHELVING SYSTEM

SPG INTERNATIONAL LLC, C...

1. A shelving system including a shelf having first and second opposed sides and a weight supporting surface for storing or displaying articles, the shelving system comprising:first and second vertical support posts, each vertical support post having a height and first and second opposed exterior surfaces that face away from each other and a third exterior surface that is orthogonal to and couples the first and second opposed exterior surfaces; and
a plurality of support pins fixed to each of the first and second vertical support posts and spaced along the height of each of the first and second vertical support posts and extending away and outwardly from at least one of the surfaces of the first and second opposed exterior surfaces on each of the first and second vertical support posts; and
first and second support brackets, each of the first and second support brackets comprising a pair of spaced-apart opposed flanges and a surface orthogonal to and in contact with the pair of spaced-apart opposed flanges,
wherein the first support bracket is configured such that in an assembled state of the shelving system the pair of spaced-apart opposed flanges of the first support bracket is coupled to the first vertical support post with one flange of the pair of spaced-apart opposed flanges positioned in contact with the first exterior surface of the first vertical support post and the other flange of the pair of spaced-apart opposed flanges is positioned in contact with the second exterior surface of the first vertical support post, wherein each flange of the pair of spaced-apart opposed flanges includes at least one aperture configured to releasably engage one of the plurality of support pins on the first vertical support post, each aperture formed as a slot with an open end, wherein the first support bracket is configured such that in the assembled state of the shelving system the surface that is orthogonal to and in contact with the pair of spaced-apart flanges contacts and extends across the third exterior surface of the first vertical support post, and wherein the first support bracket is configured such that in the assembled state of the shelving system the first support bracket cooperates with the first vertical support post to support the first side of the shelf on a support surface, and
wherein the second support bracket is configured such that in the assembled state of the shelving system the second support bracket is coupled to and cooperates with the second vertical support post to support the second side of the shelf on a support surface; and
first and second cooperating brackets, each of the first and second cooperating brackets comprising a coupling portion configured to removably couple the shelf with one of the first and second vertical support posts and a support portion connected to the coupling portion and configured to support one of the first and second sides of the shelf,
wherein the coupling portion of the first cooperating bracket is configured such that movement of the first cooperating bracket in a direction parallel to a longitudinal axis of the first vertical support post to couple the first cooperating bracket to the first support bracket constrains rotational movement of the first cooperating bracket relative to the first support bracket, wherein the first cooperating bracket is configured such that in the assembled state of the shelving system the first cooperating bracket is positioned between the first support bracket and the first side of the shelf to support the first side of the shelf, couples the shelf to the first vertical support post, and spaces the first side of the shelf from the first support bracket, wherein the first cooperating bracket is configured such that in the assembled state of the shelving system the support portion supports a portion of the shelf and the coupling portion transmits a loading force from the first side of the shelf to the first vertical support post, wherein the first cooperating bracket is configured such that in the assembled state of the shelving system the first cooperating bracket does not extend above a top side of the first support bracket and the first cooperating bracket hinders movement of the shelf in a direction orthogonal to a plane coincident with the third exterior surface of the first vertical support post,
wherein the second cooperating bracket is configured such that in the assembled state of the shelving system the second cooperating bracket is positioned between the second support bracket and the second side of the shelf to support the second side of the shelf, couples the shelf to the second vertical support post, and spaces the shelf from the second support bracket, and
wherein in the assembled state of the shelving system the weight supporting surface of the shelf does not extend above a top side of each of the first and second support brackets.

US Pat. No. 10,455,953

CHANNEL GLIDE ASSEMBLIES

Monster Energy Company, ...

1. A channel glide system comprising:a channel unit comprising a channel configured to receive a first column of beverage containers, the channel bounded at least partially by a first base, a first lateral fence, and second lateral fence;
a front stop unit removably connected with a front of the channel unit, the front stop unit comprising a first pillar and a second pillar, the first pillar comprising a first catch and the second pillar comprising a second catch, the first catch and the second catch being laterally spaced apart from each other;
wherein the first catch and the second catch each comprise a cantilevered free end with a front-most inner corner that engages with a sidewall of a front-most of the beverage containers, the front-most inner corner being rounded to reduce the likelihood of damage to the sidewall; and
a plurality of rear stop units each configured to removably connect with the channel unit, the plurality of rear stop units comprising:
a first type having a first length and being configured to receive a first number of beverage containers; and
a second type having a second length and being configured to receive a second number of beverage containers, the second number being greater than the first number;
wherein the number of beverage containers that can be received by the channel is adjustable based on whether the first or second type of rear stop unit is connected to the channel unit at the rear of the channel.

US Pat. No. 10,455,948

MULTIMEDIA CHAIR

1. A multimedia chair comprising:a base having opposing seat supports and opposing side supports;
a seat connected to said seat supports;
an arm rest attached to each side support;
a controller;
a display supported by one of said arm rests and connected to said controller;
a multimedia module connected to said controller;
an adjustable foot support pivotably attached to the seat,
a foot support locking device connected to the adjustable foot support and said controller and actuated by said controller, wherein said adjustable foot support is initially in a stowed, locked and disabled position when the multimedia chair is not in use and optionally extends outward when the foot support locking device is activated by said controller and unlocked;
a back seat comprising a support rod pivotably connected between said opposing side supports and a back seat member carried by said support rod;
a back seat locking device supported by one of said side supports and connected to said back seat and said controller and actuated by said controller, wherein said back seat is initially in a forward, locked and disabled position making the multimedia chair unusable and movable rearward into an enabled position for use of the multimedia chair when said back seat locking device is activated by said controller and unlocked, said back seat locking device further comprising a locking pin that engages said support rod to lock the back seat into the forward, locked and disabled position; and
a user authorization module connected to said controller, wherein upon receiving a credit card authorization or wireless authorization signal from a wireless device of a potential user, said controller unlocks the foot support locking device and back seat locking device and actuates the display and multimedia module for use of the multimedia chair by the user.

US Pat. No. 10,455,945

THORACIC REGION COMFORT SEATING SYSTEM

Lear Corporation, Southf...

1. A seat comprising:a seatback including a support surface, wherein the seatback extends in an upright direction from a seat bottom;
a thoracic support structure pivotally attached to the seatback adjacent a top surface of the support structure for movement between a first position and a second position, wherein a bottom surface of the support structure is positioned at a height above the seat bottom in the upright direction in order to align the bottom surface with at least a portion of a user's thoracic region; and
an actuator disposed between the support surface and the support structure, wherein actuation of the actuator pivots the support structure from the first position to the second position, wherein in the second position the bottom surface moves away from the seatback so the thoracic support structure lifts and supports at least a portion of the thoracic region of the user's spine.

US Pat. No. 10,455,937

DRAWER RELEASE

1. A drawer assembly with a release, comprising:a drawer;
a drawer release comprising a handle portion pivotally engaged to a fixed portion;
the fixed portion attached to or connected to a front portion of the drawer;
the handle portion extends an entire width or substantially the entire width of the front portion of the drawer;
the drawer engaged to a drawer slide, the drawer slide comprising an outer member and an inner member, the inner member attached to the drawer, the inner member slides relative to the outer member to provide a sliding movement to the drawer slide, the drawer slide having a lock that prevents the sliding movement of the drawer slide, the drawer slide having a lever rotatably mounted to the drawer slide, wherein the lever is moveable to release the lock of the drawer slide and allow the sliding movement of the drawer slide; and,
the drawer release comprising at least one engaging member that extends from the handle portion, and the at least one engaging member engages a surface of the lever of the drawer slide of the drawer to open or release the lock to allow the sliding movement of the drawer slide, and wherein a pulling motion applied to the handle portion causes the at least one engaging member to move in a substantially vertical direction to press against the surface of the lever to open or release the lock of the drawer slide.

US Pat. No. 10,455,935

POST AND DECK COMBINATION FOR A SHELF ASSEMBLY

Affinity Hardware Co., Lt...

1. A post and deck combination for a shelf assembly, comprising:a vertical post, wherein the vertical post is hollow and includes an outer wall, wherein a plurality of slots is disposed at different heights of the outer wall, wherein each of the plurality of slots has a positioning portion;
a deck, wherein the deck is disposed parallel to a ground, wherein a coupling board is disposed on an edge of the deck and includes a first insertion groove having a first receiving end; and
a coupling member, wherein the coupling member is columnar and includes a first end, a second end, and a columnar portion interconnected between the first end and the second end, wherein the columnar portion includes a first section adjacent to the first end and a second section adjacent to the second end, wherein a diameter of the first section is smaller than a width of each positioning portion of the vertical post, wherein the second section is interconnected to the first section and has a diameter to be received in the first receiving end of the first insertion groove, wherein the columnar portion has decreasing diameters from the second end toward the first section, wherein the second section includes an inclined guiding face, wherein the coupling member is configured to extend through one of the plurality of slots to couple with the vertical post, wherein the positioning portion of the one of the plurality of slots is located at the first section of the coupling member, wherein the first insertion groove of the coupling board is coupled with the first end of the coupling member, wherein the first receiving end is located on the inclined guiding face of the second section, and wherein the coupling board is movable toward the first section.

US Pat. No. 10,455,933

GLASS CERAMIC WORKTOP

EUROKERA S.N.C., Chateau...

1. An item of equipment, comprising:at least one worktop that includes a transparent monolithic tempered glass or glass-ceramic material substrate, a surface area of said substrate being greater than 0.7 m2, a flatness of said substrate being less than 0.1% of a diagonal of the substrate, and an expansion coefficient of said substrate being less than or equal to 15·10?7 K?1, wherein a light transmission TL of said substrate is greater than 10% and an opacity indicator of said substrate is between 5 and 90;
at least one heating element; and
at least one interface for communication with at least one element of the worktop or with at least one external element for wireless communication,
wherein said item of equipment is devoid of light source(s).

US Pat. No. 10,455,931

ORAL CARE IMPLEMENT

Colgate-Palmolive Company...

1. An oral care implement comprising:a handle; and
a head extending along a longitudinal axis from a proximal end to a distal end, the head comprising:
a front surface;
a rear surface opposite the front surface;
a peripheral surface extending between the front and rear surfaces and defining a perimeter edge of the front surface;
a plurality of tooth cleaning elements extending from the front surface;
an elastomeric component including a bumper portion that forms a distal-most section of the peripheral surface and a wall portion located along a distal-most section of the perimeter edge and protruding above the front surface;
the wall portion extending along the perimeter edge in a continuous manner from a first point of the perimeter edge to a second point of the perimeter edge, the first and second points located on opposite sides of the longitudinal axis; and
the wall portion comprises a first ramped portion, an apex portion, and a second ramped portion, the apex portion disposed between the first and second ramped portions; and
wherein the wall portion has a maximum height at a third point of the perimeter edge located between the first and second points, the third point located on the longitudinal axis and on the apex portion.

US Pat. No. 10,455,925

BACKPACK WITH INTEGRAL RAINCOAT

1. A backpack with an integral raincoat, the backpack comprises of:a bag that has a top, a bottom, a front and rear side and a pair of shoulder straps that are attached to the rear side of the backpack, the rear side of the backpack defines a central opening that defines a first compartment that runs from a top rear side of the backpack toward a bottom rear side of the backpack;
a retractable roller mechanism that has a strap, the strap has a first end and a second end, the first end of the strap is attached to the roller mechanism and the roller mechanism is attached to the first compartment of the backpack; and
a raincoat that is attached to the second end of the strap, the bag defines at least one front compartment in the front of the bag.

US Pat. No. 10,455,924

SLEEPING PAD FOR SLEEPING COT

NEMO EQUIPMENT, INC., Do...

1. A flexible contoured sleeping pad comprised of a plurality of inflatable cells, said flexible contoured sleeping pad configured for being disposed upon a support surface having a sag when measured from first and second outer side edges of said support surface towards a central region of said support surface, for creating a generally level sleeping surface on said support surface having a sag, comprising:the flexible contoured sleeping pad having a length, a width and a top and bottom surface, said width defined by first and second longitudinal edges, wherein said top and bottom surfaces are joined proximate said first and second longitudinal edges in defining a plurality of sleeping pad inflatable cells disposed between said top and bottom surfaces; and
said flexible contoured sleeping pad comprising a plurality of sleeping pad inflatable cells including one or more inflatable cells proximate a central portion of said width of said flexible contoured sleeping pad and first and second inflatable cells disposed proximate said first and second longitudinal edges respectively, said first and second inflatable cells disposed proximate said first and second longitudinal edges having a first thickness proximate said first and second longitudinal edges and said one or more inflatable cells proximate a central portion of said width of said flexible contoured sleeping pad having a second thickness proximate a central region of said width at a point approximately one-half of a distance between said first and second longitudinal edges, said second thickness being greater than said first thickness, wherein a thickness of said flexible contoured sleeping pad increases from said first thickness proximate said first and second longitudinal edges to said second thickness proximate a central region in gradual thickness increments in successive and adjoining inflatable cells which increments correspond generally to said sag in said support surface, such that said flexible contoured sleeping pad is configured for creating a generally level sleeping surface on said support surface having a sag when measured from said first and second outer side edges of said support surface towards said central region of said support surface.

US Pat. No. 10,455,912

CANOPIES AND CANOPY SUPPORT STRUCTURES

ARTiculatedshade, LLC, B...

1. A canopy support structure, comprising:a support pole having a track therein, thereon, or coupled thereto, wherein the track extends in a longitudinal direction along the support pole;
a three-dimensional array of hub pairs including a primary hub pair and at least two secondary hub pairs, the hubs of each hub pair being movable toward each other during extension of the canopy support structure and away from each other during retraction of the canopy support structure,
wherein the primary hub pair includes a first hub and a second hub,
wherein each of the first hub and the second hub is coupled to the support pole,
wherein at least one of the first hub and the second hub is slidably engaged with the track and movable along the support pole; and
wherein the at least two secondary hub pairs comprises a first secondary hub pair, each hub of the first secondary hub pair comprises a respective secondary canopy support structure mount, and the secondary canopy support structure mounts are configured to receive a third hub pair of a secondary canopy support structure and axially align the third hub pair with the first secondary hub pair; and
a plurality of articulating arms connecting the primary and secondary hub pairs,
wherein the articulating arms include sets of scissor-connected primary articulating arms, and
wherein each of the primary and secondary hub pairs is pivotally connected to at least one other of the primary or secondary hub pairs by a respective set of the scissor-connected primary articulating arms.

US Pat. No. 10,455,899

LACE GUIDE FOR AN ARTICLE OF FOOTWEAR

NIKE, Inc., Beaverton, O...

1. A lace guide for an article of footwear comprising:a base;
a body protruding from the base; and
an enlarged head at a distal end of the body;
wherein the body, the base, and the enlarged head define an external channel that extends at least partially around the body to receive and retain a lace;
wherein the enlarged head has a lip extending from a periphery of the enlarged head toward the base, narrowing a width of the external channel at the lip;
the lip is asymmetrical;
the lip has a curved edge extending at an acute angle from the periphery of the enlarged head in a direction around the body and along the external channel.

US Pat. No. 10,455,881

ADJUSTABLE HEADGEAR MOUNT SYSTEM

CADEQUIP, INC., St-Jean-...

1. A headgear mount system configured for attaching a bayonet connector having a clipping lever to a headgear mount, the system comprising:a receiver element defining a female receiver cavity defined by opposing side walls and a bottom element, said cavity configured to receive a portion of the bayonet connector therein, and wherein a slot is defined in said bottom element of the female receiver cavity; and
an adjustable catch positioned in the slot of the receiver element, the catch comprising:
a catch platform configured to slidingly engage the slot defined in the receiver element; and
a tooth configured to engage the clipping lever of the bayonet connector;
wherein the catch is adjustable about and between a first catch position, in which the catch is a first distance from a front surface of the receiver element, and a second catch position in which the catch is a second distance from the front surface of the receiver element that is less than the first distance.

US Pat. No. 10,455,866

FLOCKED SHAPEWEAR GARMENTS

Spanx, Inc., Atlanta, GA...

1. A shapewear garment for control of an abdominal region, the garment comprising:a. at least one fabric panel that extends over at least the abdominal region; and
b. a fabric portion applied to the fabric panel, the fabric portion including a tummy covering portion that extends over at least a portion of the abdominal region and a pair of lateral portions extending laterally from lateral sides of the tummy covering portion;
wherein:
at least one of the lateral portions has subportions bifurcating to define therebetween a portion without the fabric portion; and
the tummy covering portion and the pair of lateral portions provide compression to the abdominal area.

US Pat. No. 10,455,863

CARTRIDGE FOR ELECTRONIC VAPING DEVICE

Altria Client Services LL...

1. A cartridge for an e-vaping device, the cartridge comprising:a housing including first and second ends;
at least first and second reservoirs positioned within the housing between the first and second ends, the first and second reservoirs extending in parallel longitudinally between the first and second ends of the housing, the first and second reservoirs being configured to hold respective first and second pre-vapor formulations;
a first gasket defining a first end of the first and second reservoirs, the first gasket and the first end of the housing defining a first space within the housing;
a second gasket defining a second end of the first and second reservoirs, the second gasket and the second end of the housing defining a second space within the housing; and
at least first and second vaporizer assemblies positioned within the housing on opposite ends of the first and second reservoirs, the first vaporizer assembly being coupled to the first reservoir and extending into the first space between the first and second reservoirs and the first end of the housing, the first vaporizer assembly being configured to vaporize the first pre-vapor formulation to generate a first vapor in the first space, the second vaporizer assembly being coupled to the second reservoir and extending into the second space between the first and second reservoirs and the first end of the housing, the second vaporizer assembly being configured to vaporize the second pre-vapor formulation to generate a second vapor in the second space; and
at least one electrode electrically coupled to the first and second vaporizer assemblies via separate, respective electrical leads.

US Pat. No. 10,455,862

ELECTRONIC CIGARETTE WITH INTELLIGENT BATTERY MODULE

SHENZHEN CHUANGYUANTENG T...

1. An electronic cigarette, comprising:a cigarette housing;
a cartridge received in said cigarette housing for storing a predetermined amount of liquid solution;
a vaporizer received in said cigarette housing and connected to said cartridge, said vaporizer having a vaporizing chamber and comprising a heating element in said vaporizing chamber for atomizing said liquid solution; and
an intelligent battery module, which comprises:
a battery casing having a connecting terminal electrically connected to said vaporizer;
a battery supporting tray received in said battery casing for accommodating at least one battery;
a Printed Circuit Board (PCB) supported in said battery casing and is electrically connected to said battery supporting tray;
a Main Control Unit (MCU) implemented on said PCB;
a resistance detection circuitry implemented on said PCB and is electrically connected to said MCU and said heating element of said vaporizer for detecting a resistance of said heating element, in such a manner that when said resistance of said heating element as detected by said resistance detection circuitry reaches a predetermined upper threshold, said MCU is configured to lower or cut off a voltage supplied to said heating element so as to prevent said temperature of said heating element from further increasing, wherein when said resistance of said heating element as detected by said resistance detection circuitry reaches a predetermined lower threshold, said MCU is configured to supply a normal voltage to said heating element of said vaporizer; and
a temperature sensor electrically connected to said MCU and said heating element of said vaporizer so as to detect a temperature of said heating element,
wherein said resistance detection circuitry comprise a voltage monitoring module and a current monitoring module electrically connected to said temperature sensor and said MCU for detecting a voltage and a current of said heating element respectively,
wherein said intelligent battery module further comprises a terminal matching circuitry electrically connected to said battery supporting tray and said MCU for disconnecting electrical connection between said batteries and said MCU when said terminals of said batteries are improperly connected in said battery compartments, said terminal matching circuitry comprising two Metal-Oxide-Semiconductor Field Effect Transistor (MOSFETs), and a driver module connected between said MOSFETs and said MCU, said MOSFETs being electrically connected together in series, said driver module being electrically connected to a Pulse-Width-Modulation terminal of said MCU, and being configured to be actuated by a potential difference between a negative terminal and a positive terminal of said batteries.

US Pat. No. 10,455,844

METHODS FOR TREATING AN OBJECT WITH CHLORINE DIOXIDE

ICA TRINOVA, LLC, Newnan...

1. A method for treating an object with chlorine dioxide gas while minimizing chlorine-containing residue on the object, comprising contacting the object with chlorine dioxide gas while exposing the object to less than 1000 lux of light, wherein the chlorine dioxide gas is generated at less than 1000 lux of light, the object comprises a raw agricultural product, the chlorine dioxide concentration adjacent the object during said treating step is 5 mg/L or less, and the chlorine-containing residue comprises chlorate, perchlorate, or a combination thereof.

US Pat. No. 10,455,829

LIGHT IRRADIATION DEVICE AND LIGHT IRRADIATION SYSTEM

NEC CORPORATION, Tokyo (...

1. A light irradiation device comprising:an imager that images a monitoring region;
a projector comprising a phase-modulation-type space modulation element,
wherein the projector irradiates the monitoring region with signal light comprising modulation light reflected by a display surface of the phase modulation element;
a controller that controls the imager to image the monitoring region and controls the projector to emit the signal light;
a propeller that moves the light irradiation device in the air; and
a flight controller that controls flight of the light irradiation device by controlling the propeller; and
at least one slave device that is detachable, the slave device being configured to be attached to a light irradiation target and comprising a light emission unit that generates guidance light for guiding a flying object,
wherein the controller controls, when recognizing the light irradiation target to be irradiated with the signal light on image data imaged by the imager, the projector to emit the signal light toward the light irradiation target,
wherein the projector displays a phase distribution, the phase distribution for displaying an objective image on a projected surface, and
wherein the projector irradiates the display surface of the phase modulation element with light.

US Pat. No. 10,455,821

ROTOR BRAKE MECHANISM FOR SPINNING REEL

SHIMANO INC., Sakai, Osa...

1. A rotor brake mechanism for a spinning reel that brakes a rotor rotatably mounted to a reel body, in conjunction with the swinging of a bail arm between a line-winding posture and a line-releasing posture, the system comprising:a braking member disposed in the reel body;
a moving member disposed in the rotor so as to move, in conjunction with the bail arm, to a first position corresponding to the line-winding posture and to a second position corresponding to the line-releasing posture, the moving member including an extended portion that extends toward the braking member when the moving member moves to the second position;
an elastic member disposed on the extended portion of the moving member, so as to come into contact with an outer peripheral surface of the braking member when the moving member moves to the second position; and
an adjustment member disposed between the extended portion of the moving member and the elastic member, so as to adjust a position of the elastic member.

US Pat. No. 10,455,816

SENSOR BASED ACTIVITY MONITOR

International Business Ma...

1. An apparatus for detecting activity quantity of an object, comprising:a single integrated circuit device having integrated therein:
a sensor configured to sense one or more movements of the object, and to generate a first sensing signal based on the sensed one or more movements, the first sensing signal having one or more magnitudes corresponding to the sensed one or more movements;
a signal level comparator comprising:
a differential amplifier configured to receive the first sensing signal at a first input node of the differential amplifier and receive a threshold value signal at a second input node of the differential amplifier, said threshold value signal received at said second input node as a feedback signal from an output node of said differential amplifier through a resistor circuit, compare each of the one or more magnitudes of the first sensing signal with the threshold value signal, determine one or more portions of the first sensing signal whose magnitudes exceed the threshold value signal based on a comparison result between each of the one or more magnitudes and the threshold value, and output, through the output node of the differential amplifier, the determined one or more portions of the first sensing signal as a second sensing signal to a state machine implemented by a processor;
the state machine processor capturing one or more events, each captured event corresponding to one of the one or more movements of the object, based on acceleration data included in the second sensing signal;
a counter configured to receive the captured one or more events from the state machine processor, add the received captured one or more events to an accumulated number of movements, and output the accumulated number of the movements to each of a trigger signal generator and a radio transceiver;
the trigger signal generator configured to:
determine whether at least two trigger conditions are satisfied at least based on the accumulated number of the movements received from the counter, a first trigger condition related to the accumulated number of the movements and a second trigger condition related to an elapsed time, said elapsed time being provided by a timer in synchronization with the counter; and
generate a trigger signal in response to determination that the at least two trigger conditions are satisfied; and
output the trigger signal to the radio transceiver, said transceiver being normally in an unpowered off-state:
the radio transceiver configured to:
determine whether the trigger signal is received from the trigger signal generator;
be automatically powered up to an on-state from said off-state in response to determining that the trigger signal is received;
receive the accumulated number of the movements and ID information corresponding to the object;
generate an activity quantity signal based on the accumulated number of the movements and the ID information; and
transmit the activity quantity signal over a communication network;
wherein said capturing of the one or more events further comprises: combining acceleration data included in the first sensing signal and a gait cycle of a pedestrian model to recognize an event corresponding to a movement.

US Pat. No. 10,455,805

DISPOSABLE AND BIODEGRADABLE LITTER SYSTEM FOR ANIMALS

Litter One, LLC, Waverly...

1. A biodegradable litter kit for use by an animal comprising:a foldable box comprising a tray portion for holding litter wherein the tray has a bottom and at least one side extending away from the bottom and further comprising a retractable lid such that the lid may be selectively moved from a position in which it prevents access to the tray portion of the box into a position in which an animal may access the tray of the box to deposit waste in the litter;
a substantially flat false bottom positioned within the tray wherein the false bottom is adapted to hold a layer of fresh litter at a position located between the false bottom of the tray and the retractable lid and not in contact with the bottom of the tray and wherein the false bottom defines multiple perforations wherein the perforations in the false bottom are too small to permit passage of the fresh litter to the bottom of the tray but are sufficiently large as to permit soiled litter which is partially dissolved to pass through the perforations, the false bottom being located a distance sufficient from the bottom of the tray to allow soiled litter to freely fall into and accumulate in a space defined between the false bottom and the tray bottom; and
at least one support member running between the bottom of the tray and the false bottom;
wherein the litter box and the perforated false bottom are all biodegradable and wherein the false bottom is sufficiently rigid to support the weight of the litter while defining the space.

US Pat. No. 10,455,781

METHOD FOR CONTROLLING SURFACE IRRIGATION BASED ON SURFACE WATER DEPTH INFORMATION

China Institute of Water ...

1. A method for controlling surface irrigation based on surface water depth information, comprising:Step a. measuring, by a water level and water stream information pressure sensor provided in target farmland blocks, in real time, surface water depths and water stream advancing durations of each of measuring points in a first half of a target farmland block, and transmitting the surface water depths and water stream advancing durations to a computer,
Step b. substituting, by a processor of the computer, the surface water depths and the water stream advancing durations into a surface irrigation model stored in a memory of the computer, to obtain initial values of soil infiltration parameters, substituting, by the processor of the computer, in turn the initial values of the soil infiltration parameters into the surface irrigation model, to obtain, by the processor of the computer, analogue values of surface water depths of each of measuring points having water before a preset measuring point when the water stream in the first half of the target farmland block has advanced to the preset measuring point, by using an objective function that an average value of errors between measured values of the surface water depths of each of the measuring points having water before the preset measuring point and the analogue values of the surface water depths of each of the measuring points having water before the preset measuring point when the water stream in the first half of the target farmland block has advanced to the preset measuring point is minimum, establishing, by the processor of the computer, a soil infiltration parameter solving model, and reversely solving and optimizing the soil infiltration parameters, and
Step c. substituting, by the processor of the computer, the soil infiltration parameters that are obtained by the reversely solving and optimizing into the surface irrigation model stored in the memory of the computer, to predict, by the processor of the computer, a complete process of the surface irrigation, and adjusting, by the processor of the computer, an irrigation duration according to the prediction result, thereby realizing accurate control of the surface irrigation process,
wherein a calculating formula of the surface irrigation model stored in the memory of the computer is shown as follows:

wherein, x is a horizontal coordinate in the horizontal direction of an already known target farmland block, in units of m, t is a water stream advancing duration in the first half of the target farmland block that is actually measured, in units of s, h is a surface water depth in the first half of the target farmland block that is actually measured, in units of m, Q is a discharge per unit width of the water stream in the x-direction that is actually measured, in units of m3/(s·m), U is an average flow velocity of a water stream in the direction perpendicular to the x-direction that is actually measured, in units of m/s, b is a land surface elevation of the already known target farmland block, in units of m, n is a Manning roughness coefficient, with an empirical value of 0.08-0.12, in units of m/s1/3, g is the gravitational acceleration, in units of m/s2, and ic is a surface water infiltration rate, in units of m3/(s·m2), wherein, ic=k?t?-1, and k and ? are both the soil infiltration parameters.

US Pat. No. 10,455,780

IN LINE BUTTON DRIP EMITTER

1. A cylindrical drip emitter for bonding to an inner surface of a conduit having a general fluid flow direction, comprising:a cover including,
a cylindrical cavity having an open end, and
a fluid inlet providing fluid communication between an outer surface of said cover and an inner surface of said cylindrical cavity; and
a body including,
a cylindrical portion having a main axis, and a regulator chamber, and
an outlet chamber extending along said main axis, from an end of said cylindrical portion in fluid communication with said regulator chamber; said outlet chamber having an aperture facing away from said cylindrical portion and bounded by a rim;
wherein, said cylindrical portion is shaped and sized for insertion into said cylindrical cavity to form a labyrinth flow path by at least one baffle protruding inward from said inner surface of said cylindrical cavity, at least one baffle protruding outward from an outer surface of said cylindrical portion of said body, and one or more of the at least one baffle protruding outward from said outer surface of said cylindrical cavity protrudes in a direction which is in said general fluid flow direction of the conduit after said bonding;
wherein, said labyrinth flow path connects said fluid inlet of the cover to said regulator chamber when said cylindrical portion is inserted into said cylindrical cavity; and
wherein, said rim is exposed through said open end of said cylindrical cavity for bonding to said inner surface of said conduit.

US Pat. No. 10,455,778

METHOD FOR CULTIVATING CORDYCEPS MILITARIS FRUITING BODY

FOOD INDUSTRY RESEARCH AN...

1. A method for cultivating Cordyceps militaris fruiting body, comprising:a) providing a seed source, and the seed source being activated C. militaris spores or C. militaris mycelia;
b) providing a solid-state culture medium, wherein the solid-state culture medium comprises rice;
c) inoculating the rice of the solid-state culture medium of step b) with the seed source of step a), and cultivating the solid-state culture medium inoculated with the seed source until a fruiting body of C. militaris is formed;
characterized in that: the rice of the solid-state culture medium of step b) is absorbed with a tea liquid.

US Pat. No. 10,455,777

ENVIRONMENTALLY-CONTROLLED SECURITY ENCLOSURE FOR PLANT MATERIAL

1. A security device for a plant comprising:wherein the security device for a plant comprises an inner housing, an environmental system, an outer frame, and a control system;
wherein the inner housing, the environmental system, and the control system are mounted within the outer frame;
wherein the plant is contained within the inner housing;
wherein the environmental system controls the environmental conditions within the inner housing;
wherein the environmental system is an apparatus that maintains the temperature and humidity within the inner housing;
wherein the environmental system comprises a temperature module and a humidity control;
wherein the temperature module is an apparatus that controls the temperature within the inner chamber of the inner housing;
wherein the humidity control is an apparatus that controls the humidity within the inner chamber of the inner housing;
wherein the control system is an electrical device that limits access into and out of the inner housing;
wherein the control system regulates the environmental conditions maintained within the inner housing;
wherein the control system comprises a logic module, a communication module, a display, a keypad, an electronic lock, an air temperature sensor, a humidity sensor, a carbon dioxide sensor, and a pressure sensor;
wherein the logic module, the communication module, the display, the keypad, the electronic lock, the air temperature sensor, the humidity sensor, the carbon dioxide sensor, and the pressure sensor are electrically interconnected;
wherein the inner housing is a first hollow rectangular block structure;
wherein the inner housing comprises an inner structure, an inner panel, an exchange fan, a makeup fan, and a first open face;
wherein the inner housing further comprises a first lamp, a second lamp, and a third lamp;
wherein the inner panel, the exchange fan, the makeup fan, the first lamp, the second lamp, and the third lamp are mounted on the inner structure;
wherein the outer frame is a housing that contains the inner housing, the environmental system, and the control system;
wherein the outer frame comprises an outer structure, a front cover, a door frame, a glass door, an exhaust fan, tank cover, and a second open face;
wherein the front cover, the door frame, the glass door, the exhaust fan, the tank cover and the second open face are attached to the outer structure;
wherein the inner panel forms an interior chamber of the inner housing; wherein the inner panel is a separate rectangular plate that is used to enclose the first open face;
wherein the inner panel comprises a first door aperture;
wherein the first door aperture forms an aperture into the inner structure;
wherein the exchange fan is mounted through a wall of the inner structure;
wherein the exchange fan expels air from the interior chamber of the inner housing;
wherein the makeup fan is mounted through a wall of the inner structure;
wherein the makeup fan pumps air into the interior chamber of the inner housing;
wherein the first lamp is a UVC lamp;
wherein the second lamp is a UVC lamp;
wherein the third lamp is a UVC lamp;
wherein the first lamp, the second lamp, and the third lamp are identical.

US Pat. No. 10,455,763

HARVEST ANALYSIS SYSTEM INTENDED FOR USE IN A MACHINE

DINAMICA GENERALE S.P.A.,...

1. A combine (2) including a harvest analysis system, the harvest analysis system comprising at least an image acquisition device (4, 40) and at least a processing unit (1) connected to said acquisition device (4, 40) and in turn comprising:at least a memory module (10), wherein at least a first reference image is stored; and
at least a comparison module (11, 12) configured for making a comparison between the images relating to the harvested products acquired by said device (4, 40) and said reference image;
wherein the combine includes an internal conveyor and processing path for the harvested products, located between cutting and picking means of the harvest (6) and a tank (7);
wherein the combine comprises, downstream of said cutting means, devices for conveying the cut products to a separation device (9), based on whose action the grains are separated from the rest of the plant for being brought into a sieving station (91) of the combine, in which they are subject to the action of different separators that allow the grains to be isolated from the useless parts and then conveyed by means of an elevator (93) towards said tank (7), where they accumulate;
wherein said image acquisition device (4) is placed downstream of the cutting means (6) but upstream of the separation device (9);
wherein the combine includes at least a NIR device (5) connected to the processing unit (1) and able to acquire the spectrum of electromagnetic radiation reflected and/or absorbed by the harvested products, wherein the processing unit (1) comprises a composition module (13) configured for assessing the chemical composition of the harvested products on the basis of the respective spectrum detected by said NIR device (5);
wherein the NIR device (5) is arranged along the conveyor and processing path upstream of the tank (7).

US Pat. No. 10,455,762

SUGAR BEET HARVEST APPARATUS

1. A root crop harvest apparatus, comprising:a frame having a coupling adapted to mechanically couple with a tractor;
at least one field cultivator affixed to said frame and having a ground piercing tooth;
at least one disc affixed to said frame, displaced from and trailing said at least one field cultivator along a longitudinal axis of said root crop harvest apparatus; and
at least four helical screw propellers affixed to said frame, displaced from and trailing said at least one field cultivator and said at least one disc along said longitudinal axis of said root crop harvest apparatus;
a first pair of said at least four helical screw propellers arranged in a V-shaped configuration within a horizontal plane configured to be immediately adjacent to and generally parallel to a surface of the earth; and
a second pair of said at least four helical screw propellers arranged in a V-shaped configuration within a plane parallel to and above said plane defined by said first pair of said at least four helical screw propellers, and extending more distally to said at least one field cultivator than said first pair of said at least four helical screw propellers.

US Pat. No. 10,455,759

QUICK RELEASE BEARING COUPLERS

CNH Industrial Canada, Lt...

1. An agricultural metering system, comprising:a releasable bearing coupler configured to selectively couple a meter roller to a housing of the agricultural metering system, wherein the releasable bearing coupler comprises:
a shaft configured to be disposed through an opening in the housing and to engage a bearing, wherein the bearing is configured to be disposed within a recess of the meter roller to facilitate rotation of the meter roller about the shaft and to couple the meter roller to the housing via contact with the shaft; and
a locking segment configured to selectively interlock with a corresponding locking feature of the housing to secure the releasable bearing coupler to the housing.
US Pat. No. 10,457,825

UV CURABLE INKJET INK COMPOSITIONS

ELECTRONICS FOR IMAGING, ...

1. A UV curable inkjet ink composition, comprising:a monofunctional urethane acrylate component constituting 12-35% by weight of the UV curable inkjet ink composition, said monofunctional urethane acrylate component comprising either of a monomer and an oligomer;
an additional monomer component constituting 10-80% by weight of the UV curable inkjet ink composition, the 10-80% by weight of the additional monomer component is in addition to the 12-35% by weight of the monofunctional urethane acrylate component when the monofunctional urethane acrylate component is a monomer;
a photoinitiator component constituting 1-15% by weight of the UV curable inkjet ink composition; and
an additional oligomer component constituting more than 0% but no more than 20% by weight of the UV curable inkjet ink composition, the no more than 20% by weight of the additional oligomer component is in addition to the 12-35% by weight of the monofunctional urethane acrylate component when the monofunctional urethane acrylate component is an oligomer.
US Pat. No. 10,457,826

LEAD REFILL FOR WRITING, DRAWING AND/OR PAINTING DEVICES AND METHOD FOR THE PRODUCTION THEREOF


US Pat. No. 10,457,830

REACTION PRODUCT AND PIGMENTED BASECOAT MATERIAL COMPRISING SAID PRODUCT

BASF Coatings GmbH, Muen...

1. A pigmented aqueous basecoat material, comprising:a reaction product which is prepared by reaction of
(a) at least one aliphatic linear polyester having two functional end groups (a.1), with
(b) at least one diene polymer having two functional end groups (b.1),
wherein at least one type of group (a.1) is reacted in a linking manner with at least one type of group (b.1), said components (a) and (b) are used in the reaction in a molar ratio of 2.3/0.7 to 1.7/1.6 and the resulting reaction product possesses a number-average molecular weight of 1000 to 15 000 g/mol.
US Pat. No. 10,456,817

ENVIRONMENT-FRIENDLY AND IN SITU IMMOBILIZED METHOD OF RENOVATING HEAVY METAL CONTAMINATED SOIL WITH HUMIC ACID SUBSTANCE

China University of Petro...

1. A environment-friendly and in situ immobilized method of renovating heavy metal contaminated soil with humic acid substance, comprising:1) while the heavy metal contaminated soil is being pulverized, adding humic acid substance into the soil according to weight ratio 5-20:1 of the humic acid substance to the total heavy metals contained in the soil, to allow in-situ reduction and solidification of the heavy metals, then aging the soil for more than 24 hours after the pulverization process to allow humic acid substance promoting soil agglomeration so as to encapsulate and block the exudation and migration of heavy metals in soil particles, thereby forming soil water-stable granular structures with humic acid substance;
2) adding 1-3 parts by weight of semi-coke bacterial fertilizer to 100 parts by weight of the water-stable granular structures, and mixing uniformly to continuously produce active humic acid substances, so as to ensure that the water-stable aggregate are not destroyed.
US Pat. No. 10,457,844

HEAT TRANSFER METHODS, SYSTEMS AND COMPOSITIONS

HONEYWELL INTERNATIONAL I...

1. A refrigerant consisting essentially of:about 38% by weight difluoromethane (HFC-32),
from 57% to 59% by weight trifluoroiodomethane (CF3I); and
from 2% to 5% by weight of CO2.
US Pat. No. 10,455,793

SOYBEAN CULTIVAR 69090024

M.S. Technologies, L.L.C....

1. A plant of soybean cultivar 69090024, representative seed of said soybean cultivar having been deposited under ATCC Accession No. PTA-125313.
US Pat. No. 10,455,797

SOYBEAN CULTIVAR S170108

M.S. Technologies, L.L.C....

1. A plant of soybean cultivar S170108, representative seed of said soybean cultivar having been deposited under ATCC Accession No. PTA-125437.
US Pat. No. 10,459,131

RETROREFLECTIVE SHEETING AND VEHICLE LICENSE PLATE

NIPPON CARBIDE INDUSTRIES...

1. A retroreflective sheeting, comprising an outermost surface protective layer, wherein, the surface protective layer comprises at least one acrylic polymer, the coagulation ratio of which is 0%-95%; the glass-transition temperature (Tg) of the product generated from the reaction of the acrylic polymer of the surface protective layer is 10° C.-35° C.;wherein the acrylic polymer is a polymer with a weight-average molecular weight of more than 30,000; the number of carbon atoms in the alkyl acrylate monomer is 3-12; and
wherein the surface protective layer of the retroreflective sheeting also comprises a retentive layer, a focusing layer and a light-reflecting layer laminated successively from top to bottom; a glass microbead is arranged between the retentive layer and the focusing layer; the glass microbead is embedded in the retentive layer and the focusing layer respectively; the thickness of the surface protective layer is 75% larger than the diameter of the glass microbead.
US Pat. No. 10,457,850

REDUCED CORROSION IRON SULFIDE SCALE REMOVING FLUIDS

SAUDI ARABIAN OIL COMPANY...

1. A low-corrosivity composition suitable for dissolving scale on metal, where the scale comprises iron sulfide scale, the composition consisting of:an aqueous hydrogen peroxide solution comprising hydrogen peroxide, where the hydrogen peroxide is present at about between 0.5% and about 1.5% by weight of the composition; and
an acidic solution comprising at least one acid, where the acidic solution comprises acetic acid present at about between 0.25% and about 2.5% by weight of the composition, where the hydrogen peroxide and acid are present at concentrations such that the hydrogen peroxide does not break down to form visible bubbles at about room temperature,
where the hydrogen peroxide and acid are present at concentrations such that the iron sulfide scale is removed from the metal with iron sulfide scale, after the composition contacts the metal and iron sulfide scale at an elevated temperature greater than room temperature, and
where the hydrogen peroxide and acid are present at concentrations such that pitting is not caused on the metal, the metal comprising carbon steel, and where the balance of the composition is at least about 90 weight % water to form a dilute, low-corrosivity solution mixture.
US Pat. No. 10,455,799

SOYBEAN CULTIVAR S170074

M.S. Technologies, L.L.C....

1. A plant of soybean cultivar S170074, representative seed of said soybean cultivar having been deposited under ATCC Accession No. PTA-125455.
US Pat. No. 10,457,852

SILOXANE SURFACTANT ADDITIVES FOR OIL AND GAS APPLICATIONS

Flotek Chemistry, LLC, H...

1. A well treatment additive comprising:a siloxane surfactant in an amount between about 10 wt % and about 15 wt % versus the total well treatment additive, wherein the siloxane surfactant has a formula selected from the group consisting of: MDa(D?R1)bM (formula 1) and (M?R1)Da(M?R1) (formula 2)
wherein “R1” represents an organic radical comprising —(CH2)n—(OCH2CH2)x—(OCH(CH3)CH2)y—OR3, in which “n” is between 3 and about 11, “x” is between 3 and about 30, “y” is between 0and about 30, and “R3” is —H;
wherein “M” represents Me3SiO1/2, D represents —Me2SiO—, “M?R1” represents Me2(R1)SiO1/2—, “D?R1” represents —Me(R1)SiO—, and “Me” represents —CH3;
wherein for formula 1, “a” is 0-200 and “b” is 1-20;
wherein for formula 2, “a” is 4-50; wherein the siloxane surfactant is a trisiloxane ethoxylate graft-type copolymer
a hydrocarbon surfactant in an amount between about 10 wt % and about 35 wt % versus the total well treatment additive, wherein the hydrocarbon surfactant is selected from the group consisting of polyoxyethylene alky ethers, dialkyl sulfosuccinates, alkyl sulfates, sulfonates, carboxylates, amine oxides, primary alkylamines, dialkyl secondary amines, ethoxylated fatty amines, and combinations thereof;
a solvent, wherein the solvent is a terpene hydrocarbon in an amount between about 5 wt % and about 40 wt % versus the total well treatment additive; and
an aqueous phase.
US Pat. No. 10,457,854

THERMALLY-STABLE, NON-PRECIPITATING, HIGH-DENSITY WELLBORE FLUIDS

Halliburton Energy Servic...

1. A method of treating a portion of a subterranean formation penetrated by a well comprising:introducing a treatment fluid into the well, wherein the treatment fluid comprises:
(A) a base fluid; and
(B) a water-soluble salt, the salt comprising:
(i) a cation selected from the group consisting of ammonium, phosphonium, quaternary amines, poly-quaternary amines, rare earth elements, and any combination thereof; and
(ii) an anion, wherein the anion is selected from phosphotungstate, silicotungstate, and silicomolybdate.
US Pat. No. 10,456,834

PROCESS FOR THE PRODUCTION OF SINTERED MOLDINGS

BASF SE, Ludwigshafen am...

1. A process for the production of sintered moldings which comprises:molding a mixture comprising
A. a sinterable metallic powder and
B. a binder comprising polyoxymethylene or a polyoxymethylene copolymer having at least 50 mol % of —CH2O— repeat units in the main polymer chain
to give a compact;
removing the binder from the compact by treatment with a gaseous acid to obtain a molding; and
sintering the molding;
wherein the acid is selected from the group consisting of methanesulfonic acid, a mixture of methanesulfonic acid with oxalic acid, a solution of methanesulfonic acid in a solvent selected from the group consisting of water, C1-4-carboxylic acids and mixtures thereof, a solution of a mixture of methanesulfonic acid and oxalic acid in a solvent selected from water, C1-4-carboxylic acids and mixtures thereof, and a solution of oxalic acid in water,
wherein B is a thermoplastic composition comprising
from 10 to 90% by weight of a polyoxymethylene homo- or copolymer with a weight-average molar mass (Mw) in the range from above 60,000 to 200,000 g/mol as component B1.1 and
from 10 to 90% by weight of a polyoxymethylene copolymer with a weight average molar mass (Mw) in the range from 10,000 to 60,000 g/mol, as component B1.2, the molecular weights being determined by way of gel permeation chromatography.
US Pat. No. 10,457,618

PHARMACEUTICAL COMPOSITIONS COMPRISING MONOTERPENES

NeOnc Technologies, Inc.,...

1. A process for purifying (S)-perillyl alcohol consisting essentially of the steps of:(a) derivatizing a mixture comprising (S)-perillyl alcohol to form a perillyl alcohol derivative, wherein the perillyl alcohol derivative is a 3,5-dinitrobenzoate ester derivative of perillyl alcohol;
(b) crystallizing the perillyl alcohol derivative;
(c) separating the perillyl alcohol derivative crystals from the mixture;
(d) releasing the (S)-perillyl alcohol from the separated perillyl alcohol derivative from step (c); and,
(e) isolating the (S)-perillyl alcohol from step (d).
US Pat. No. 10,457,880

FUEL ADDITIVE COMPOSITION AND RELATED METHODS AND COMPOSITIONS

Purify Founders, LLC, Wa...

1. A fuel additive composition comprising:(a) hydrotreated heavy paraffinic distillates present in amount ranging from 20 wt. % to 50 wt. % based on the fuel additive composition;
(b) solvent-dewaxed heavy paraffinic distillates present in amount ranging from 25 wt. % to 50 wt. % based on the fuel additive composition; and
(c) petroleum distillates comprising hydrocarbons having from 5 to 16 carbon atoms and present in an amount ranging from 20 wt. % to 50 wt. % based on the fuel additive composition.
US Pat. No. 10,457,881

FUEL COMPOSITIONS

SHELL OIL COMPANY, Houst...

1. A marine fuel composition comprising:55 to 90 wt % of a residual hydrocarbon component selected from an atmospheric tower bottoms (ATB) residue, a vacuum tower bottoms residues (VTB), or any combination thereof, wherein the residual hydrocarbon component has a kinematic viscosity at ˜50 degrees C. of at least 100 cSt; and
at least 10 and up to 45 wt % of the marine fuel composition selected from a non-hydroprocessed hydrocarbon component, a hydroprocessed hydrocarbon component, or any combination thereof, wherein the non-hydroprocessed hydrocarbon component comprises deasphalted oil (DAO);
wherein the marine fuel composition has a kinematic viscosity at ˜50 degrees C. of at least 10 cSt.
US Pat. No. 10,456,345

FURTHER PREPARATIONS OF SILK PROTEINS, SEED OILS, MONOSACCHARIDE, NATURAL BOTANICALS AND POLYSACCHARIDE MIXTURES IN COMPOSITIONS FOR HAIR CARE OR HAIR REPAIR, AND SKIN CARE AND TOPICAL TREATMENTS

Valerie M. Ross, San Die...

1. A topical composition comprising: sericin; chitosan; and ribose; wherein the sericin, chitosan, and ribose are part of a first phase comprising water, and wherein the topical composition comprises a water-in-oil emulsion formed from the first phase and a second phase comprising at least one seed oil.
US Pat. No. 10,457,884

MIXED DETERGENT COMPOSITION FOR INTAKE VALVE DEPOSIT CONTROL

Afton Chemical Corporatio...

1. A detergent additive package for an unleaded gasoline fuel comprising a Mannich base detergent mixture, wherein the mixture comprises a first Mannich base detergent component having a tertiary amino group and derived from an aliphatic linear, branched, or cyclic diamine having one primary or secondary amine group and one tertiary amino group in the molecule and a second Mannich base detergent component derived from a monoamine, wherein a weight ratio of the first Mannich base detergent to the second Mannich base detergent in the mixture ranges from about 1:6 to about 3:1.
US Pat. No. 10,456,347

COMPOSITION FOR INJECTION OF HYALURONIC ACID, CONTAINING HYALURONIC ACID DERIVATIVE AND DNA FRACTION, AND USE THEREOF

BMI KOREA CO., LTD, Jeju...

1. A method for repair or replacement of biological tissue, filling wrinkle, remodeling of the face or increasing lip volume, skin rehydration by mesotherapy, replacement or supplement of joint synovial fluid or treating dry eye syndrome, comprising administering to the subject an effective amount of an injectable hyaluronic acid composition comprising hyaluronic acid derivatives having the degree of crosslinking of 0.1 to 200% wherein the concentration of the hyaluronic acid derivative is 1 to 50 mg/ml and DNA fractions of 0.1 to 50 wt % based on the total composition.
US Pat. No. 10,458,911

METHOD FOR SEARCHING CANDIDATE MATERIAL FOR ANTI-CANCER DRUG USING LOCALIZED SURFACE PLASMON RESONANCE

KOREA UNIVERSITY RESEARCH...

1. A method for screening an anticancer candidate, comprising:immobilizing gold nanoparticles onto a substrate;
forming a STAT3 protein conjugate by binding a STAT3 protein involved in carcinogenesis and metastasis to the immobilized gold nanoparticles, recording a spectrum of the protein conjugate as the STAT3 protein is undergoing a phosphorylation or a dimerization step without the presence of the candidate, and analyzing the spectrum of the STAT3 protein conjugate to obtain reference data;
forming a mixture by adding a candidate inhibiting the activity of the STAT3 protein to the STAT3 protein conjugate, recording a spectrum of the mixture as the STAT3 protein is undergoing a phosphorylation or a dimerization, and analyzing the spectrum of the mixture to obtain comparative data; and
comparing the reference data with the comparative data to determine whether the candidate inhibits the activity of the protein,
wherein the addition of the candidate inhibiting the activity of the protein induces changes in the phosphorylation and dimerization of the STAT3 protein and the binding profile of the STAT3 protein with the gold nanoparticles on the substrate.
US Pat. No. 10,456,350

EYE MAKE-UP COSMETIC COMPOSITION WITH EXCELLENT CURLING HOLDING FORCE

AMOREPACIFIC CORPORATION,...

1. A cosmetic composition for eye makeup, which comprises low-specific gravity volatile oil and low-specific gravity powder, and a dispersant,wherein the low-specific gravity volatile oil comprises low-specific gravity hydrocarbon oil and low-specific gravity volatile silicone oil,
wherein a specific gravity of the low-specific gravity hydrocarbon oil is equal to or more than 0.1 and equal to or less than 0.8, and a specific gravity of the low-specific gravity silicone oil is equal to or more than 0.1 and equal to or less than 0.85, and the specific gravity of the low-specific gravity powder is equal to or more than 0.001 and less than 1, when the specific gravity of the standard material, pure water at 4° C., is taken as 1, wherein the composition is a non-aqueous composition not comprising water or aqueous ingredients.
US Pat. No. 10,456,607

PHOTOACTIVE GRAFTED POLYSACCHARIDE AND USE THEREOF IN COSMETICS

1. A polysaccharide polymer grafted with photoactive groups of an azide or diazirine of formula (I):PS—(O—CO-L-X)a(OH)b  (I)
in which PS denotes the basic backbone of the polysaccharide bearing the hydroxyl groups;
L is a linear, branched or cyclic, saturated or unsaturated divalent hydrocarbon-based group comprising from 1 to 20 carbon atoms, which may be interrupted with one or more non-adjacent heteroatoms chosen from sulfur, oxygen, or —NH—, —COO—, —CONH—, —O—CO—NH— or —NH—CO—NH— groups, said divalent group optionally substituted with one or more groups chosen from hydroxyl, amine, thiol, carboxylic acid, amide, cyano, and acyl (C1-C4)amino groups;
X denotes the azide or diazirine photoactive group;
a denotes the content of OH groups substituted with the photoactive group;
b denotes the content of unsubstituted free OH groups;
a being between 0.02 and 0.5; b being between 0.5 and 0.98;
and a+b=1;
with the exception of compounds (I) for which:
PS is dextran and -L-X=—(CH2)5—N3
PS is hyaluronic acid and -L-X=—(CH2)3—N3.
US Pat. No. 10,456,352

OXIDATION DYEING AGENT WITH SPECIAL HYDROXY-TERMINATED, AMINE-FUNCTIONALIZED SILICONE POLYMERS

1. Cosmetic agent for coloring keratin fibers, comprising in a cosmetically tolerant carriera) at least one chromophoric compound, selected from the group of oxidative dye precursors, partially-oxidative dyes and the mixtures thereof,
b) at least one hydroxy-terminated amine-functionalized silicone polymer of formula (I)
(O1/2H)t[A]a  (I)
where A=(SiO4/2)k(R1SiO3/2)m(R12SiO2/2)p(R13SiO1/2)q(O2/2SiR1—(CH2)x—B—(CH2)y—NH2)s(O1/2SiR1R2—(CH2)x—B—(CH2)y—NH2)r
wherein
the at least one hydroxy-terminated amine-functionalized silicone polymer of formula (I) is terminated at a first end with a hydroxy group and is terminated at a second end with an amine group,
a denotes integers from 1 to 20,000, wherein, if a ?2, the respective values k, m, p, q, s and r in a structural element A can be selected irrespective of previous structural elements A,
R1 and R2 denote, independently of one another, hydrogen, a OH group, a linear or branched C1-C12-alkyl group, a phenyl group or a vinyl group,
B denotes an oxygen atom, a NH group or sulfur,
x and y denote, independently of one another, integers from 1 to about 10,
t denotes integers from 1 to 5, and
the total of k+m+p+q+s+r denotes integers from 3 to about 20,000.
US Pat. No. 10,457,894

COLOR-PROTECTING DETERGENT OR CLEANING AGENT HAVING AN OPTICAL BRIGHTENER

1. A water-soluble packaging having at least two chambers and containing a first liquid detergent or cleaning agent with a low content of water, a second liquid detergent or cleaning agent with a low content of water and a water-soluble wrapping, said first liquid detergent or cleaning agent with a low content of water containing an optical brightener and said second liquid detergent or cleaning agent with a low content of water containing a color transfer inhibitor, wherein low content of water is less than 15% by weight in each case in relation to the total first and/or second liquid detergent or cleaning agent; and wherein the first liquid detergent or cleaning agent is free from color transfer inhibitors and the second liquid detergent or cleaning agent is free from optical brighteners.
US Pat. No. 10,456,357

ORALLY ADMINISTRABLE FORMULATION

1. An aqueous-based oral liquid formulation comprising a solvent comprising water, alcohol and propylene glycol and/or polyethylene glycol in an amount in the range of about 60-99% by wt, wherein the formulation comprises up to 40% by wt water, up to 65% by wt alcohol and up to 50% by wt propylene glycol and/or polyethylene glycol combined with pharmaceutical agent-containing particles of plant material in an amount in the range of about 1-40% by wt, wherein the pharmaceutical agent is selected from the group consisting of cannabinoids, cannabinoid derivatives, terpenes and mixtures thereof, and at least 50% by wt of the particles range in size from about 50 to about 2000 ?m.
US Pat. No. 10,457,898

LIQUID DETERGENT COMPOSITION COMPRISING CELLULOSIC POLYMERS AND CELLULASE

1. A liquid laundry detergent composition comprising:a. between about 0.0001% and about 0.1% by weight of the liquid laundry detergent composition of a cellulase;
b. between about 0.05% and about 3% by weight of the liquid laundry detergent composition of a first cellulosic polymer, wherein the first cellulosic polymer is a cationically modified cellulosic polymer;
c. between about 0.05% and about 3% by weight of the liquid laundry detergent composition of a second cellulosic polymer wherein the second cellulosic polymer is a hydrophobically modified carboxymethyl cellulose having a degree of substitution (DS) of from about 0.01 to about 0.99 and a degree of blockiness (DB) such that either DS+DB is of at least about 1.00 and/or DB+2DS-DS2 is at least about 1.20.
US Pat. No. 10,457,900

DETERGENT COMPOSITION COMPRISING AN ALKYL ETHER SULFATE-RICH SURFACTANT SYSTEM AND COATED ENCAPSULATES

1. A liquid detergent composition comprising:A) from about 15% to about 60%, by weight of the detergent composition, of a surfactant system, wherein the surfactant system comprises:
a) an anionic alkoxylated alkyl sulphate surfactant present at a level of about 90% to 100%, by weight of the surfactant system;
b) up to 5% by weight of the surfactant system of a linear alkyl benzene sulfonate;
c) up to 5% by weight of the surfactant system of a nonionic surfactant selected from the group consisting of an alkoxylated fatty alcohol, an amine oxide, or mixtures thereof;
B) from about 0,1% to about 5%, by weight of the composition, of encapsulates, wherein the encapsulates comprise a core and a wall at least partially surrounding the core, wherein the core comprises a benefit agent, and the wall comprises a coating on an outer surface of the wall; and
C) an external structurant.
US Pat. No. 10,456,874

MANGANESE-CONTAINING, COBALT-BASED HIGH-TEMPERATURE SOLDER ALLOY, POWDER, COMPONENT AND SOLDERING METHOD

SIEMENS AKTIENGESELLSCHAF...

1. A cobalt-based solder alloy comprising:8% by weight—16% by weight of zirconium (Zr);
6% by weight—10% by weight of tantalum (Ta);
0.5% by weight—1.5% by weight of carbon (C),
8% by weight—12% by weight of manganese (Mn);
at least 0.5% by weight of titanium (Ti); and
having no boron (B), no silicon (Si), no germanium (Ge) and no gallium (Ga).
US Pat. No. 10,456,365

METHODS AND FORMULATIONS FOR SUPPORTING AND PROMOTING BONE HEALTH

1. A method for treating osteoporosis in a human being in need thereof comprising administering to said human being a therapeutically effective amount of ?-Caryophyllene.
US Pat. No. 10,455,854

NUTRITIONAL COMPOSITIONS CONTAINING STRUCTURED FAT GLOBULES AND USES THEREOF

MEAD JOHNSON NUTRITION CO...

1. A powdered nutritional composition comprising:a carbohydrate source;
a lipid or fat source, wherein the lipid or fat source comprises milk fat globules formed from an enriched lipid fraction derived from bovine milk that has been subjected to a fractionation procedure, further wherein the milk fat globules comprise from about 40 wt. % to about 55 wt. % saturated fatty acids, from about 35 wt. % to about 45 wt. % monounsaturated fatty acids, and from about 1.4 wt. % to about 6 wt. % polyunsaturated fatty acids, based on the total weight of the lipids present in the milk fat globules;
a protein source; and
a preservative.
US Pat. No. 10,457,910

METHOD FOR DEEP DEHYDRATION AND DESICCATION OF CYANOBACTERIA

JIANGSU PROVINCIAL ACADEM...

1. A method for deep dehydration and desiccation of cyanobacteria, comprising:(1) adding a flocculant into a cyanobacteria slurry discharged from an algae-water separation station for conditioning;
(2) pumping the cyanobacteria slurry after the flocculation conditioning into a high pressure diaphragm plate-frame for pressure filtration;
(3) desiccating the cyanobacteria slurry in a quartz glass box after the pressure filtration;
wherein a top surface of said quartz glass box is a quartz glass with high transparency, and material of a periphery and an underside of the box is corrosion-resistant stainless steel,
wherein a polymer hydrophobic membrane is positioned at an inner surface of the quartz glass with high transparency, and contact angles on two surfaces of the polymer hydrophobic membrane are both greater than 75°, and
wherein light transmittance of the quartz glass with high transparency is greater than 90%, average light reflectivity is below 4%, and minimum of the light reflectivity is less than 0.5%.
US Pat. No. 10,456,373

AGENT EXHIBITING ANTI-STRESS, ANXIOLYTIC AND ANTI-DEPRESSION ACTIVITY, AND COMPOSITION BASED THEREON

1. A composition useful for treating stress, anxiety or depression in a subject, wherein the following components are present within the composition in the following mass percent ratios: 10-90% lithium ascorbate, 6-50% vitamin B6, and 4-40% vitamin B1.
US Pat. No. 10,456,374

PYRROLIDONE CARBOXYLIC ACID (PCA) FOR OPHTHALMIC USE

Laboratori Baldacci S.p.A...

1. A method for treating ocular diseases and/or disorders in a subject, comprising administering to a subject (i) pyrrolidone carboxylic acid and/or a pharmaceutically acceptable salt thereof, wherein the pharmaceutically acceptable salt is selected from the group consisting of: carbonate, hydrochloride, hydrobromide, sulfate, hydrogen sulfate, citrate, maleate, fumarate, trifluoroacetate, 2-naphthalenesulfonate, and para-toluenesulfonate, and (ii) one or more active ingredient selected from the group consisting of a metal salt, hyaluronic acid, a cellulose derivative, an osmoprotectant, and a mixture thereof, wherein (i) and (ii) are the only active ingredients administered to the subject.
US Pat. No. 10,456,630

USE OF FARNESENE, POLYFARNESENE AND FARNESENE COPOLYMER FOR GOLF BALLS

Callaway Golf Company, C...

9. A golf ball comprising:a core;
a mantle layer;
a cover;wherein at least one of the core, the mantle layer and the cover comprises a blend material of a highly neutralized ionomer and at least one of a farnesene, a poly(farnesene), or a farnesene copolymer.
US Pat. No. 10,457,916

METHOD FOR INDUCING DIFFERENTIATION OF INSULIN-PRODUCING CELLS

Tokyo Institute of Techno...

1. A method for directed differentiation into insulin-producing cells, comprising culturing endodermal cells in the following steps (a) to (d):(a) culturing the endodermal cells in a medium comprising a hedgehog signaling inhibitor and an FGF;
(b) culturing the cells obtained in step (a) in a medium comprising a retinoic acid receptor agonist, a hedgehog signaling inhibitor and noggin;
(c) culturing the cells obtained in step (b) in a medium comprising a TGF-? type I activin receptor-like kinase-4/-5/-7 inhibitor and noggin; and
(d) culturing the cells obtained in step (c) in a medium comprising GLP-1 receptor agonist and nicotinamide to produce insulin-producing cells,
wherein the concentration of the noggin in steps (b) and (c) is at least 200 ng/ml or more.
US Pat. No. 10,456,378

FAST ACTING ORALLY DISINTEGRATING FILM

TAHO Pharmaceuticals Ltd....

1. A fast acting orally disintegrating film, comprising:ondansetron or a pharmaceutical acceptable salt thereof in an amount of about 2 to about 24 mg;
a first hydrophilic film forming polymer comprising hydroxylpropylmethylcellulose (HPMC) in a total amount of from about 15% to about 50% by weight of said film, wherein said first hydrophilic film forming polymer is characterized by having a molecular weight of about 5000Da to about 50000Da and viscosity of about 3 cps or about 6 cps;
a second hydrophilic film forming polymer comprising HPMC characterized by having a molecular weight between about 50000Da to about 60000Da and viscosity of about 15 cps, and said first hydrophilic film forming polymer is mixed with said second hydrophilic film forming polymer in a ratio from about 0.3:1 to about 7:1; and
a water soluble excipient comprising polyethylene glycol (PEG) in an amount of about 10% to about 30% by weight of said film;
wherein the fast acting orally disintegrating film disintegrates within about 30 seconds in about 20 cc of water at about 37 degrees Celsius and lightly shaken.
US Pat. No. 10,456,383

TARGETED APPROACH IN THE MANAGEMENT OF EPIDERMOLYSIS BULLOSA

The Board of Trustees of ...

1. A method for the targeted treatment of Epidermolysis Bullosa simplex (EBS) caused by a genetic mutation in one or both of keratin K5 and keratin K14, to improve clinical severity of lesional skin, the method comprisingcontacting topically a lesion of a patient suffering from EBS with an effective dose of a formulation comprising 0.1% to 5% rapamycin.
US Pat. No. 10,457,929

COMPOSITIONS FOR THE TREATMENT OF GLUTEN INTOLERANCE AND USES THEREOF

Glutagen Pty Ltd., Victo...

1. A method for the prophylaxis or treatment of gluten intolerance, the method comprising administering to a subject in need thereof an oral composition that contains a first component comprising caricain at about 5% w/w to about 95% w/w, based on the total weight of the first component of the oral composition, and a second component comprising at least one pharmaceutically acceptable carrier, excipient, or diluent.
US Pat. No. 10,458,964

METHOD FOR RAPIDLY DETERMINING SULFUR CONTENT IN A PLURALITY OF SAMPLES

1. A method of measuring the sulfur content in a plurality of individual sulfur-containing fiber or article samples, the method comprising the steps of:a) contacting a plurality of sulfur-containing fiber or article samples with an aqueous solution comprising potassium hydroxide to convert the sulfur to potassium sulfate;
b) concurrently and individually combusting the plurality of samples from step a) in a furnace at a temperature of greater than 650° C. to remove essentially all organic materials and produce a plurality of residues;
c) dissolving each of the pluralities of residue in concentrated nitric acid to form individual residue solutions; and
d) analyzing the individual residue solutions with Inductively Coupled Plasma (ICP) Emission Spectrometry to determine the sulfur content of each sample.
US Pat. No. 10,457,940

AAV TREATMENT OF HUNTINGTON'S DISEASE

University of Massachuset...

1. An isolated nucleic acid comprising a transgene encoding one or more mature, single-stranded miRNAs, wherein the nucleic acid sequence of the transgene encoding each mature, single-stranded miRNA comprises the sequence set forth in SEQ ID NO: 7, and is flanked by a heterologous miRNA backbone sequence.
US Pat. No. 10,458,197

DISINTEGRATABLE POLYMER COMPOSITES FOR DOWNHOLE TOOLS

BAKER HUGES, A GE COMPANY...

1. A disintegrable polymer composite comprising:a polymer component comprising one or more of the following: a cured cyanate ester; a crosslinked unsaturated polyester; or a crosslinked vinyl ester resin and
dissolvable glass comprising about 55 to about 80 wt. % of SiO2, 0 to about 35 wt. % of Na2O, 0 to about 35 wt. % of K2O, 0 to about 20 wt. % of CaO, 0 to about 10 wt. % of MgO, provided that the sum of the weights of Na2O and K2O is about 20 wt. % to about 40 wt. %, wherein each weight percent is based on the total weight of the dissolvable glass, the dissolvable glass having a solubility in water of greater than 15 grams/millimeter at 25° C.;
wherein the composite further comprises an additive different from the dissolvable glass, the additive comprising one or more of the following: CaO; MgO; Ca(OH)2; Mg(OH)2; Mg; Zn; a formate of sodium or potassium; an octoate of Zn or Mn or Cu or Co; a naphthenate of Zn or Mn or Cu or Co; aramid fibers; nylon fibers; cellulosic biodegradable fibers; a water soluble or biodegradable polymer different from the polymer component.
US Pat. No. 10,457,942

EXOSOMES AND MICRO-RIBONUCLEIC ACIDS FOR TISSUE REGENERATION

Cedars-Sinai Medical Cent...

1. A method for producing a therapeutic composition comprising:harvesting a population of exosomes from cardiospheres or cardiosphere-derived cells (CDCs) wherein said exosomes comprise microRNAs mir-210 and miR-146a.
US Pat. No. 10,456,404

TARGETING CGMP-RELATED PHOSPHODIESTERASES TO REDUCE CYST FORMATION IN CYSTIC KIDNEY DISEASE, AND RELATED MATERIALS AND METHODS

Indiana University Resear...

1. A method for preventing the progression of and/or treating a cystic kidney disease in a subject in need thereof, comprising administering an effective amount of at least one phosphodiesterase inhibitor, at least one pharmaceutically effective phosphodiesterase inhibitor prodrug, at least one pharmaceutically active phosphodiesterase inhibitor metabolite, or a combination thereof to the subject, wherein the phosphodiesterase inhibitor and the pharmaceutically active phosphodiesterase inhibitor metabolite individually inhibits at least one phosphodiesterase selected from the group consisting of: phosphodiesterase type 5; phosphodiesterase type 6; and phosphodiesterase type 9, and the pharmaceutically effective phosphodiesterase inhibitor prodrug is convertible to an active inhibitor of at least one phosphodiesterase selected from the group consisting of: phosphodiesterase type 5; phosphodiesterase type 6; and phosphodiesterase type 9.
US Pat. No. 10,457,959

EFFICIENT SELECTIVITY OF RECOMBINANT PROTEINS

REGENERON PHARMACEUTICALS...

1. A vector comprising a nucleic acid, wherein the nucleic acid comprises(i) a mammalian tunicamycin (Tn)-resistance gene encoding a protein having at least 93% identity to the amino acid sequence of SEQ ID NO: 3,
(ii) a first a gene of interest (GOI), and
(iii) at least one regulatory element,
wherein the Tn-resistance gene is operably linked to the first GOI and said at least one regulatory element, and
wherein the first GOI encodes a protein selected from the group consisting of an antibody light chain or antigen-binding fragment thereof, an antibody heavy chain or antigen-binding fragment thereof, and an Fc-fusion protein or a fragment thereof.
US Pat. No. 10,457,960

METHODS AND COMPOSITIONS FOR TARGETED GENETIC MODIFICATION USING PAIRED GUIDE RNAS

Regeneron Pharmaceuticals...

1. An in vitro method for making a biallelic modification to a genomic target locus in a genome within a cell, comprising:(I) introducing into a population of cells:
(a) a Cas protein;
(b) a first guide RNA that hybridizes to a first CRISPR RNA recognition sequence within the genomic target locus;
(c) a second guide RNA that hybridizes to a second CRISPR RNA recognition sequence within the genomic target locus; and
(d) a targeting vector comprising a nucleic acid insert flanked by a 5? homology arm that hybridizes to a 5? target sequence within the genomic target locus and a 3? homology arm that hybridizes to a 3? target sequence within the genomic target locus;
wherein the genome comprises a pair of first and second homologous chromosomes comprising the genomic target locus; and
wherein the Cas protein cleaves at least one of the first and second CRISPR RNA recognition sequences to generate at least one double-strand break in each of the first and second homologous chromosomes; and
(II) identifying a cell comprising a modified genomic target locus comprising a deletion and/or an insertion, wherein the identifying comprises performing a quantitative modification-of-allele assay and a retention assay,
wherein the modification-of-allele assay comprises:
(a) a gain-of-allele assay to determine a copy number of a region of the nucleic acid insert in a genomic DNA sample from the cell; and/or
(b) a loss-of-allele assay to determine a copy number in the genomic DNA sample of a region of the genomic target locus targeted for deletion, and
wherein the retention assay determines a copy number in the genomic DNA sample of a region of the 5? target sequence to which the 5? homology arm hybridizes and/or determines a copy number in the genomic DNA sample of a region of the 3? target sequence to which the 3? homology arm hybridizes,
wherein the combination of the modification-of-allele assay and the retention assay distinguishes correct targeted insertion of the nucleic acid insert into the genomic target locus from random transgenic insertions of the nucleic acid insert into genomic locations outside of the genomic target locus and/or distinguishes correct targeted deletions from deletions extending beyond the region of the genomic target locus being targeted for deletion.