US Pat. No. 10,245,550

SEPARATION METHOD AND SEPARATION DEVICE

Kobe Steel, Ltd., Kobe-s...

7. A separation device for separating a desired component from a starting material gas, which is a mixed gas containing the desired component as an object to be separated, the separation device comprising:an absorber for absorbing the desired component in the starting material gas into an absorption liquid by bringing the introduced starting material gas and the absorption liquid into contact with each other;
a regenerator for releasing the desired component from the absorption liquid having absorbed the desired component in the absorber and regenerating the absorption liquid;
a regeneration-side separator, connected to the regenerator so that a mixed fluid consisting of the desired component gas released in the regenerator and a regenerated absorbing liquid is introduced from the regenerator to the regeneration-side separator, for separating the introduced mix fluid into the desired component gas and the absorption liquid; and
a compressor for compressing the starting material gas to generate compression heat in the starting material gas, wherein:
the regenerator comprises: a regeneration unit, connected to the absorber so that the absorption liquid having absorbed the desired component in the absorber is introduced from the absorber to the regeneration unit, for releasing the desired component from the introduced absorption liquid and regenerating the absorption liquid; and a temperature controlling unit for the regenerator, connected to the compressor so that the starting material gas compressed in the compressor is introduced from the compressor to the temperature controlling unit for the regenerator, for heating the absorption liquid introduced into the regeneration unit by performing heat exchange between the introduced starting material gas and the absorption liquid introduced into the regeneration unit, and;
the absorber is connected to the temperature controlling unit for the regenerator so that the starting material gas, which has been compressed by the compressor and undergone heat exchange with the absorption liquid in the temperature controlling unit for the regenerator, is introduced into the absorber,
wherein:
the regeneration unit, connected to the absorber so that the absorption liquid having absorbed the desired component in the absorber is introduced into the regeneration unit, comprises a plurality of regeneration passages formed as microchannels for circulating the introduced absorption liquid, thereby releasing the desired component from the absorption liquid and regenerating the absorption liquid;
the temperature controlling unit for the regenerator, connected to the compressor so that the starting material gas compressed in the compressor is introduced into the temperature controlling unit for the regenerator, comprises a plurality of temperature controlling passages for the regenerator formed as microchannels for circulating the introduced starting material gas and performing heat exchange between the starting material gas and the absorption liquid circulating in the regeneration passages, thereby heating the absorption liquid circulating in the regeneration passages; and
the regenerator comprises a laminate on which a regeneration passage layer in which a plurality of the regeneration passages are arranged and a temperature controlling passage layer in which a plurality of the temperature controlling passages for the regenerator are laminated.

US Pat. No. 10,245,545

EMBOSSED AIR FILTER FILTRATION MEDIUM, FILTER PACK, AIR FILTER UNIT, AND METHOD FOR MANUFACTURING FILTRATION MEDIUM FOR EMBOSSED AIR FILTER

Daikin Industries, Ltd., ...

1. An embossed air filter filtration medium for trapping dust in a stream of air, the embossed air filter filtration medium comprising:an air filter filtration medium having
at least one porous film including
a fibril-formable polytetrafluoroethylene,
a non-fibril-forming and non-hot-melt-processable component, and
a non-fibril-forming and hot-melt-processable component having a melting point below 320° C., and
a plurality of air-permeable support materials supporting the at least one porous film,
surfaces of both sides of the air filter filtration medium being formed by two air-permeable support materials of the plurality of air-permeable support materials, and
the air filter filtration medium being provided with a plurality of embossed projections.

US Pat. No. 10,245,544

AIR CLEANER ARRANGEMENTS; COMPONENTS; AND METHODS

Donaldson Company, Inc., ...

10. An air cleaner assembly comprising:(a) a housing defining an interior;
(i) the housing defining a service access end with a removable access cover positioned thereover; and,
(ii) the access cover including a central projection thereon, extending into the housing interior from the access cover;
(iii) the central projection on the access cover having a sidewall portion with a serpentine shape;
(b) a filter cartridge positioned in the housing and comprising:
(i) a media pack comprising pleated media surrounding an open interior; the media having first and second ends;
(ii) a first end cap positioned on the media first end and extending completely across the first end of the media between media inner and outer perimeters; and,
(iii) a second end cap positioned on the media second end and extending at least completely across the second end of the media between media inner and outer perimeters;
(iv) a portion of one of the end caps including a radially directed surface having a serpentine shape with at least five each of alternating radially facing convex and radially facing concave portions;
(A) the radially directed surface having a serpentine shape with an outer cross dimension that is smaller than an outer cross-dimension of an outermost portion of the media pack.

US Pat. No. 10,245,543

AIR FILTER SYSTEMS AND METHODS OF USING THE SAME

DONALDSON COMPANY, INC., ...

1. An air filter system comprising:a tube sheet configured to separate a housing into a dirty air chamber and a clean air chamber;
a pulse collector defining a passageway that extends through the pulse collector from a filter end opening at a filter end of the pulse collector element to a tube sheet opening at a tube sheet end of the pulse collector;
an aperture in the tube sheet, wherein the tube sheet end of the pulse collector is configured for attachment to the tube sheet such that the tube sheet opening of the pulse collector is aligned with the aperture such that air passing from the dirty air chamber into the clean air chamber through the aperture passes through the passageway of the pulse collector;
a filter element attached to the filter end of the pulse collector such that air passing into the passageway of the pulse collector through the filter end opening of the pulse collector passes through an interior volume of the filter element before reaching the filter end opening, wherein the filter element comprises a filter element opening at a junction between the filter end of the pulse collector and the filter element;
a pulse generator located in the clean air chamber and positioned to deliver pulses of air into the interior volume of the filter element, the pulses of air passing through the aperture and the passageway of the pulse collector before reaching the interior volume of the filter element, wherein the pulse generator is configured to deliver the pulses of air along a pulse axis that extends from the pulse generator through the aperture in the tube sheet, the tube sheet opening in the pulse collector, and the filter end opening in the pulse collector, wherein the pulse generator comprises a pulse outlet located on the pulse axis and through which the pulses of air are delivered along the pulse axis, the pulse outlet defined by opposing walls that do not diverge with respect to the pulse axis, and wherein the pulse outlet defines a pulse outlet hydraulic diameter; and
a yoke supporting the filter element, the yoke extending away from the pulse collector along the pulse axis, wherein the yoke comprises two or more support beams aligned with the pulse axis, wherein the two or more support beams are arranged asymmetrically about the pulse axis, and wherein the filter element comprises an end cap comprising notches that align with and receive the two or more support beams when the filter element is in only one rotational orientation relative to the pulse axis;
wherein a pulse distance measured along the pulse axis from the pulse outlet to the filter element opening is 30 or more times the pulse outlet hydraulic diameter.

US Pat. No. 10,245,542

FOLDABLE FILTER FRAME

1. A foldable air filter including a filter media panel and a rectangular support frame surrounding and secured to the filter media panel, the frame including opposed side frame elements having a hinge joint formed near the midpoint that allows the support frame and a dirt-capturing surface of the filter media panel to fold along lateral line from a planar, extended position to a folded position, the hinge joint having a fold line in a dirtied-side attaching panel of the side frame elements, and a cut formed through a base and a clean-side attaching panel of the side frame elements, and further including a hinge locking means for temporarily securing the hinge joint in the planar, extended position, for insertion into a furnace return air duct.

US Pat. No. 10,245,541

AIR FILTER SYSTEM, AIR FILTER ELEMENT AND METHOD FOR EXCHANGING AN AIR FILTER ELEMENT

11. A filter housing for receiving an air filter element, the filter housing comprising:a housing upper part;
a clean air connection for discharging clean air from the housing;
an annular sealing receptacle formed as an annular U-shaped groove formed into an interior wall of the filter housing, the annular groove opening in an axial direction, wherein the annular sealing receptacle includes
a cylindrical extending sealing surface extending axially from the upper housing part;
wherein the cylindrical extending sealing surface surrounds and encloses the clean air connection;
wherein the cylindrical extending sealing surface is configured to receive an annular seal of the air filter element;
a central tube is disposed in the filter housing as a continuation of the clean air connection, the central tube of the filter housing sized for being received into the air filter element during installation of the air filter element into the filter housing and to support the air filter element relative to the filter housing;
wherein the central tube is detachably installed into the filter housing or made unitary in one piece with the filter housing;
wherein the central tube has an annular collar extending radially outwardly from a radially outer side of the central tube, a radial outer side of the annular collar forming an annular projection which protrudes radially over the cylindrical extending sealing surface of the U-shaped groove formed into the interior wall of the filter housing;
the annular projection and annular sealing receptacle configured to form a form-fitting tight-fit connection with the annular seal of the air filter element during installation of the air filter element in the filter housing, by radially compressing an annular region of the annular seal to form a annular groove into which the annular projection is received.

US Pat. No. 10,245,539

VIRTUAL IMPACTOR FILTER ASSEMBLY AND METHOD

General Electric Company,...

1. A virtual impactor filter assembly comprising:a filter housing having a cylindrical sidewall defining an interior chamber, the filter housing including an inlet opening spaced a separation distance from an outer air flow housing that directs a flow of air having particles along a flow direction into the interior chamber of the filter housing through the inlet opening, the cylindrical sidewall including a plurality of exit openings extending therethrough;
a filter medium disposed in the interior chamber of the filter housing along an inner surface of the cylindrical sidewall, the filter medium removing particles from the flow of air having particles to provide a filtered air flow that exits the filter housing through the plurality of exit openings; and
a volume defined between the filter housing and the outer air flow housing along the flow direction to permit at least some of the flow of air to flow, via the separation distance, through the volume and pass around an exterior of the filter housing, and exit the outer air flow housing while the particles in the at least some of the flow of air pass into the interior chamber of the filter housing through the inlet opening wherein the filter housing is configured to engage with the outer air flow housing such that the filter housing is separated from the outer air flow housing along the flow direction by an air gap.

US Pat. No. 10,245,536

FILTER HEAD AND THREADED METAL NOZZLE INSERT

Mahle International GmbH,...

1. A filter head, comprising:a plastic injection molded receiving component having a receiving cavity and a threaded metal nozzle insert disposed in the receiving cavity and at least partly injected into the plastic injection molded receiving component;
the threaded metal nozzle insert defining an axis and structured as a cold extruded part;
the plastic injection molded receiving component defining an axial sealing surface surrounding an opening into the receiving cavity circumferentially to the axis and including a plurality of integral plastic ribs disposed radially to the threaded metal nozzle insert in the receiving cavity, the plurality of integral plastic ribs extending from the threaded nozzle insert along a radial direction of the axis and leading radially outward into the axial sealing surface of the plastic injection molded receiving component; and
wherein the plurality of integral plastic ribs are axially raised at a respective radially outward portion leading into the axial sealing surface of the plastic injection molded receiving component relative to a respective radially inward portion of the plurality of integral plastic ribs disposed at the threaded nozzle insert.

US Pat. No. 10,245,534

FILTER INLINE HEATER

Shaw Development, LLC, B...

1. A filter assembly for filtering aqueous urea solution comprising a housing defining an interior region and exterior region, the interior region and the exterior region being in fluid communication through a first aperture and a second aperture;a fluid filter within the housing, the filter separating the housing into
an upstream region upstream of the filter, the upstream region in fluid communication with the second aperture, and
a downstream region downstream of the filter, the downstream region in fluid communication with the first aperture;
a heater extending into the interior region of the housing;
a first hose fitting in fluid communicating with the first aperture, the first hose fitting formed of a material having a thermal conductivity of at least 16 W/(m*K);
a second hose fitting in fluid communicating with the second aperture, the second hose fitting formed of material having a thermal conductivity of at least 16 W/(m*K);
a heat bridge
formed of a conductive material having a thermal conductivity of at least 16 W/(m*K),
thermally connecting the heater to the first hose fitting, and
thermally connecting the heater to the second hose fitting; and
a first insulator
formed of a material having a thermal conductivity of at most 0.25 W/(m*K),
the first insulator at least partially covering the first hose fitting; and
a second insulator
formed of a material having a thermal conductivity of at most 0.25 W/(m*K),
the second insulator at least partially covering the second hose fitting.

US Pat. No. 10,245,532

FILTER CENTER TUBE WITH STANDPIPE AND FLOW FINS

Caterpillar Inc., Deerfi...

1. A filter element that has a generally cylindrical configuration and that defines a longitudinal axis and a radial direction, the filter element comprising:a center tube having a length along the longitudinal axis, the center tube including:
a standpipe that defines a length along the longitudinal axis and a central flow passage that extends the majority of the length of the center tube along the longitudinal axis;
a plurality of radially extending flow fins attached to and extending from the standpipe, the flow fins spaced away axially from one another to define radial flow channels, wherein each of the fins further defines an aperture between the fin and the standpipe, the aperture together defining an outer axial flow passage that extends along the standpipe, wherein the standpipe further defines at least one radial flow passage that is in fluid communication with the outer axial flow passage and the central flow passage, wherein the standpipe and the outer axial flow passage are not in fluid communication with one another along a majority of the length of the standpipe; and
an annular filter media surrounding the center tube and the central flow passage and contacting the flow fins;
a first open end joined to the center tube disposed along the longitudinal axis, the open end including an opening allowing fluid to flow from the central flow passage to the outside of the filter element; and
a second end joined to the center tube opposite the open end disposed along the longitudinal axis, the second end including a first end cap.

US Pat. No. 10,245,531

HIGH-EFFICIENCY AUTOMATIC SELF-CLEANING STRAINER

TM Industrial Supply, Inc...

12. A method of reducing an amount of fluid used during a cleaning cycle of fluid strainer assembly, said method including:providing a body defining a chamber, the body including an inlet and outlet;
positioning a cylindrical screen within the chamber, said screen being supported by the body through which a fluid being filtered must pass, said cylindrical screen defining an internal portion;
positioning a backwash port within the internal portion of the screen, said backwash port being in fluid communication with a backwash pipe for directing fluid out of the fluid strainer assembly during a cleaning cycle, said backwash port comprising a rectangular member having an axially extending port defined by a top wall, a bottom wall, and a pair of parallel sidewall members, said top wall, bottom wall, and pair of sidewall members having end portions;
supplying the fluid to be filtered into the chamber;
rotating said backwash port about a central axis such that said end portions are in a close spaced proximity relationship with respect to an inner surface of said screen defining a space for the fluid being filtered to flow between said end portions and said inner surface of said screen causing a tangential flow and backflow of the fluid in order to dislodge and remove foreign material collected on the inner surface of the screen to flow into the backwash port and exit out a discharge outlet and backwash pipe; and
dimensioning the backwash port such that an area of draw is determined by equations: i) CS×1.875×1.5?A; and ii) A?CS of backwash pipe, where CS represents an internal transverse area of the backwash pipe and A represents the area of draw of the backwash port.

US Pat. No. 10,245,530

MODULAR PLANT AND PROCESS FOR LIQUID/GAS SEPARATION, IN PARTICULAR FOR LIQUID AND GASEOUS PHASES OF A CRUDE OIL

Saipem S.A., Montigny le...

1. A unitary device for liquid/gas separation of respective liquid and gaseous phases of a fluid, wherein said unitary device for liquid/gas separation comprises a single enclosure comprising a leaktight wall that withstands pressure at the sea bottom and the internal pressure of said fluid, the leaktight wall being arranged about a vertical axis of revolution, and said enclosure containing:1) a first internal pipe for delivering the multiphase fluid, the first internal pipe rising within said enclosure from a bottom end of said first internal pipe that includes or co-operates with a first orifice passing through a wall portion referred to as the end wall of the enclosure up to an open top end opening out into the top portion of the end wall of the enclosure, and continuing up to an open top end of said first internal pipe, and opening out into a top portion of the enclosure; and
2) a gas-discharge second internal pipe extending within said enclosure from an open top end to a bottom end of said second internal pipe that includes or co-operates with a second orifice passing through the end wall of the enclosure; and
3) a third orifice passing through said end wall of the enclosure coaxially around said first and second orifices in the end wall of the enclosure.

US Pat. No. 10,245,529

SYSTEM AND APPARATUS TO IMPROVE VENTING AND SPILL MITIGATION FOR TANK

GM GLOBAL TECHNOLOGY OPER...

1. A system for improving gaseous venting and mitigating fluid spills from a fluid storage vessel, comprising:a hollow member having a first end, a second end, and a body surface connecting the first end and the second end, the hollow member having at least one opening formed in the body surface;
a permeable membrane extending at least partially across the at least one opening formed in the body surface of the hollow member; and
a sealing member permitting one-way flow of fluid toward the fluid storage vessel;
wherein the membrane permits passage of a gas across the membrane to improve venting of the fluid storage vessel, the seal prevents spillback of fluid during fill operations, and the first end of the hollow member and the sealing member are configured to interface with a fill nozzle.

US Pat. No. 10,245,528

DEVICE FOR SKIMMING A SURFACE FLUID

TECHNIP FRANCE, (FR)

1. A device for skimming petrochemical or chemical fluid storage tanks working by gravitation, the device presenting a central vertical axis, the petrochemical or chemical fluid having a density d2 and being covered by a surface fluid with a density d1 lower than d2, the device comprising:a buoyancy apparatus floating at an interface between the fluid with density d1 and the fluid with density d2;
a collector for collecting surface fluid to be skimmed including an opening emerging above the interface between the fluid with density d1 and the fluid with density d2, the collector being connected to the buoyancy apparatus, and a connector submerged in the fluid with density d2; and
a discharger for discharging the collected surface fluid, the discharger being connected to the connector of the collector and extending vertically in the fluid with density d2 toward the bottom of the tank, the discharger comprising at least two flexible pipes connected symmetrically to the connector, the device being maintained in the tank without a guiding post, at least one part of each flexible pipe resting on the bottom of the tank.

US Pat. No. 10,245,527

SOLID-LIQUID SEPARATION DEVICE

HITACHI LTD., Tokyo (JP)...

1. A solid-liquid separation device that performs dehydration or deoiling from an object to be treated that is a mixture of water and a solid, a mixture of oil and a solid, or a mixture of water, oil, and a solid, as the object to be treated, using a substance A capable of dissolving water and oil, the solid-liquid separation device comprising:a substance B that is circulated while generating phase change in a closed system;
a compressor that compresses the substance B;
a first heat exchanger that exchanges heat of condensation of the substance B and heat of evaporation of the substance A;
a second heat exchanger that exchanges heat of evaporation of the substance B and heat of condensation of the substance A;
a treatment tank in which the substance A is mixed with the object to be treated, the substance A having been evaporated while separated from the water or the oil in the first heat exchanger, and condensed in the second heat exchanger, wherein
the first heat exchanger is installed in a lower portion than the treatment tank in a vertical direction, and
a connection port of the first heat exchanger and a lower portion of the treatment tank are connected with a flow path; and
a third heat exchanger installed downstream of the treatment tank and upstream of the first heat exchanger in a flow path system of the substance A, and which switches a flow path of the substance B flowing into the heat exchanger 1 in an upper stream of the heat exchanger 1 to exchange heat between the substance B and the substance A, wherein
the third heat exchanger is installed in a lower portion than the treatment tank in a vertical direction.

US Pat. No. 10,245,526

EXTRACTOR AND RELATED METHODS

Bridgestone Corporation, ...

1. An extractor suitable for using a solvent to separate a compound from a solid or semisolid substance containing the compound, comprising:a substance inlet for introducing the substance into the extractor;
a substance outlet for removing the substance from the extractor;
a solvent inlet for introducing the solvent into the extractor;
a solvent outlet for removing the solvent from the extractor; and
a first conveying assembly including:
an inclined first conveyor for receiving the substance from the substance inlet and moving the substance through the solvent, the first conveyor including an upper end and a lower end opposite its upper end,
wherein the first convey includes an inclined first upper surface and
an inclined first lower solid surface substantially parallel to the inclined first upper surface;
wherein the first conveyor is configured to move the substance downward through the solvent along the first upper surface toward the lower end and upward through the solvent along the first lower solid surface toward the upper end,
wherein the compound comprises rubber and the solid or semisolid substance comprises guayule plant matter.

US Pat. No. 10,245,524

START ASSIST DEVICE FOR SWIMMERS WITH POSITIONING AND REMOVAL MECHANISM

Everlast Climbing Industr...

1. A starting assist apparatus for assisting backstroke swimmers during a start process, the apparatus comprising:a footrest operable for positioning in a pool during the start process and automatic removal from the pool after the start process, wherein the positioning in the pool corresponds with an extended position of the footrest and the automatic removal from the pool corresponds with a retracted position of the footrest;
a rotatable winding tube comprising a torsion spring configured to provide a bias force to the rotatable winding tube in a first direction corresponding with the retracted position of the footrest;
a plurality of straps coupling the footrest to the rotatable winding tube, the plurality of straps configured to simultaneously wind around the rotatable winding tube if the rotatable winding tube is rotated in the first direction, the plurality of straps configured to simultaneously unwind from the rotatable winding tube if the rotatable winding tube is rotated in the second direction, wherein:
a force applied to the rotatable winding tube in a second direction that exceeds the bias force provided by the torsion spring in the first direction rotates the rotatable winding tube in the second direction to simultaneously unwind the plurality of straps to move the footrest to the extended position, and
the bias force provided by the torsion spring in the first direction automatically and simultaneously winds the plurality of straps on the rotatable winding tube to move the footrest to the retracted position in an absence of the force applied to the rotatable winding tube in the second direction that exceeds the bias force provided by the torsion spring in the first direction; and
a lock configured to allow rotation of the winding tube in the first direction to wind the plurality of straps and prevent rotation of the winding tube in the second direction to unwind the plurality of straps if the lock is in a closed position.

US Pat. No. 10,245,523

MAGNETIC BUILDING BLOCK

Shantou Xinbida Early Edu...

1. A magnetic building block, comprising:a building block front side having a center opening;
a building block back side installed on a rear end of the building block front side and having a center opening;
four notches formed on both of the rear end of the building block front side and a front end of the building block back side;
four small magnets disposed on the front end of the building block back side;
four protruding chucks disposed on both of the rear end of the building block front side and the front end of the building block back side;
an embedded paper disposed between the building block front side and the building block back side and surrounded by the notches, the small magnets and the protruding chucks;
reinforcing ribs distributed on inner walls of the building block front side and the building block back side; and
a silicone protective ring located on outer side faces of the building block front side and the building block back side,
wherein the protruding chucks and the notches on each of the front and back sides are installed such that the front and back sides each provide a protruding chuck and a notch positioned on opposite sides of each of the four small magnets, and
wherein the embedded paper has a shape conforming to a shape of the building block front side and the building block back side and has a center opening aligned with the center opening of the building block front side and the center opening of the building block back side.

US Pat. No. 10,245,522

SNOWMAN MAKER

1. A snowman maker, comprising:three sections being a lower mold section, a middle mold section, and an upper mold section, said three sections being stackable, said upper mold section is smaller than said lower and middle mold sections; said lower mold section, said middle mold section, and said upper mold section each include a top periphery and a bottom periphery, said top periphery or bottom periphery includes an opening adapted to allow a user to at least substantially fill said three sections with snow, said upper mold section includes a laterally extending upper mold bottom flange mounted to said upper mold section's bottom periphery that connects to a laterally extending middle mold top flange mounted to said middle mold section's top periphery, said middle mold section includes a laterally extending middle mold bottom flange mounted to its bottom periphery that engages a laterally extending lower mold top flange mounted to said lower mold section's top periphery, said upper, middle or lower mold section is defined by at least two mating collapsible panels that are completely pulled apart when collapsed.

US Pat. No. 10,245,520

POWERED RIDE-ON VEHICLE

Radio Flyer Inc., Chicag...

1. A powered ride-on vehicle comprising:a frame supported by a first drive wheel, a second drive wheel and at least one non-driven support wheel;
a first motor connected to the first drive wheel;
a second motor connected to the second drive wheel;
a steering wheel supported by the frame, the steering wheel having a go selector and a spin selector;
a sensor operably connected to the steering wheel to obtain an output of the angular location of the steering wheel; and,
a controller operably electrically connected to the first and second motors, the go selector, the spin selector, and the steering wheel sensor, wherein engaging the go selector and turning the steering wheel causes the vehicle to move forward, left or right, depending on the angular location of the steering wheel, and wherein engaging the spin selector and turning the steering wheel causes the vehicle to spin left or spin right, depending on the angular location of the steering wheel.

US Pat. No. 10,245,519

TOY VEHICLE

1. A toy vehicle that is manually propelled by a user to move the vehicle in a desired direction comprising:A body, said body having a front end and a rear end, said body having a first pair of wheels proximate said front end, said body having a second pair of wheels proximate said rear end, said body being configured to traverse across a surface on said first pair of wheels and said second pair of wheels;
An applied force member, said applied force member being secured to said rear end of said body, said applied force member being semicircular in shape, said applied force member having an upper portion and a lower portion, said upper portion and said lower portion being contiguous; and
Wherein said applied force member has a first position and a second position and wherein the applied force member is moved to its second position by a user applying a force on said upper portion and said lower portion.

US Pat. No. 10,245,518

TOY TOP

TOMY COMPANY, LTD., Toky...

1. A toy top comprising:a shaft portion;
a body which is rotatable relative to the shaft portion in response to an impact applied to the body; and
an attacking member movably connected to the body to move in a predetermined direction relative to the body between first and second positions,
wherein in the second position the attacking member protrudes from the body a variable protruding distance which varies according to the rotating position of the body relative to the shaft portion.

US Pat. No. 10,245,517

INTERACTIVE RIDE-ON TOY APPARATUS

Pacific Cycle, LLC, Madi...

1. An interactive ride-on toy apparatus comprising:a torso;
a plurality of legs secured to the torso;
a first drive motor assembly secured to a first of the plurality of legs and to a first drive wheel;
a second drive motor assembly secured to a second of the plurality of legs and to a second drive wheel;
a motorized neck assembly coupling a head to the torso, wherein the neck assembly provides a multi-directional rotational movement of the head relative to the torso;
a rechargeable battery;
a throttle switch to provide a throttle signal;
a controller including one or more processors and one or more memory devices; and
an electrical steering position sensor configured to translate a mechanical steering input via manual rotation of the head into an electronic steering position signal that is communicated to the controller, wherein the controller is configured to receive the throttle signal and the steering position signal, and selectively actuate at least one of the drive wheel motors based on the throttle signal and the steering position signal.

US Pat. No. 10,245,516

INFORMATION-PROCESSING SYSTEM, SERVER DEVICE, INFORMATION-PROCESSING DEVICE, STORAGE MEDIUM, AND INFORMATION-PROCESSING METHOD

NINTENDO CO., LTD., Kyot...

1. An information-processing system comprising:memory;
at least one processor; and
an input device configured to receive an input operation performed by a user directed to playing a game and posting information displayed by a display,
the at least one processor configured to:
execute an application for playing the game;
receive and process input received from the input device during execution of the application for playing the game;
receive posting information associated with the game from a server device of a posting information sharing service;
display a screen for simultaneously displaying: (i) game information that is displayed by executing the application for playing the game on the display and (ii) the posting information that is received using the posting information sharing service that is associated with the application for playing the game;
reflect the input operation received by the input device in the posting information;
the game information includes first and second objects of the game, the first and second objects of the game being different from each other;
the posting information includes first posting information that is received using the posting information sharing service and that is specifically relevant to the first object of the game and second posting information that is received using the posting information sharing service and that is specifically relevant to the second object of the game;
the game information including the first and second objects of the game and the posting information including the first and second posting information are simultaneously displayed on the screen; and
at least one of the first or second posting information simultaneously includes a textual message relating to at least one of the first or second objects of the game and a plurality of selectable buttons respectively corresponding to a plurality of different types of input operation regarding the textual message, the different types of input operation being performed by the user and received by the input device.

US Pat. No. 10,245,515

GAME MANAGEMENT DEVICE, GAME SYSTEM, AND COMPUTER-READABLE STORAGE MEDIUM HAVING PROGRAM RECORDED THEREON

KONAMI DIGITAL ENTERTAINM...

1. A game management device for managing a game, which communicates with a terminal device, and which permits a user to give an object owned by the user in the game to other user, the game management device comprising:a game information storage control unit for storing in a storage device, game information of each user, the game information storage control unit including an owned object information storage control unit for storing in a storage device, an object owned by the each user;
a priority setting unit for setting a priority for an object owned by a first user according to a first user's gift destination selecting operation of selecting a second user as a gift destination, the priority setting unit identifying an owned object already owned by the second user based on the object owned by the each user stored in the storage device, comparing the owned object already owned by the second user with the object owned by the first user to identify, among the object owned by the first user, a first object which is already owned by the second user and a second object which is not owned by the second user, the priority setting unit setting the priority based on the game information of the second user stored in the storage device including the object stored in the storage device for recommending the object owned by the first user for a gift to the second user without contacting the second user based on the identified first object and identified second object; and
a priority notification unit for transmitting to the terminal device of the first user, an information for notifying the priority set for the object owned by the first user.

US Pat. No. 10,245,512

SECTIONAL TERRAIN EDITING

Amazon Technologies, Inc....

1. A computing system for sectional terrain editing comprising:one or more processors; and
one or more memories having stored therein instructions that, upon execution by the one or more processors, cause the computing system perform operations comprising:
sectioning terrain of at least part of a virtual area associated with a video game into a plurality of terrain sections;
maintaining a plurality of terrain data collections associated with the plurality of terrain sections, each of the plurality of terrain sections having at least one associated terrain data collection of the plurality of terrain data collections;
checking out, to a first user, a first terrain data collection of the plurality of terrain data collections associated with a first terrain section of the plurality of terrain sections for editing terrain of the first terrain section in a terrain editing interface;
checking in, from the first user, the first terrain data collection; and
saving, to the first data collection, data associated with one or more edits to the first data collection made by the first user during a time that the first data collection is checked out to the first user,
wherein, during at least part of the time that the first terrain data collection is checked out to the first user, a second terrain data collection of the plurality of terrain data collections associated with a second terrain section of the plurality of terrain sections is made available to be checked out to a second user.

US Pat. No. 10,245,511

NON TRANSITORY COMPUTER-READABLE STORAGE MEDIUM AND METHOD OF CONTROLLING A COMPUTER

CAPCOM CO., LTD., Chuo-K...

1. A non-transitory computer-readable storage medium storing a program for driving a computer to function as:a virtual space generating unit for generating a three-dimensional virtual space;
a game screen displaying unit for displaying an image as a game screen taken by a virtual camera located in the virtual space;
an object displaying unit for displaying an object including a polygon in the three-dimensional virtual space, the polygon including first and second vertexes including first and second heights respectively which indicate how high the first and second vertexes are located in the virtual space; and
a fluid displaying unit for displaying pseudo three-dimensional representation of fluid in the virtual space on the game screen;
wherein the fluid displaying unit includes
a two-dimensional data acquiring unit for acquiring two-dimensional data including a two-dimensional map by processing at least part of the surface of the three-dimensional object into a two-dimensional manner, and
a simulating unit for simulating a flow of the fluid based on the first and second heights on the two-dimensional map and displaying a simulating result on the surface of the object.

US Pat. No. 10,245,508

METHOD AND SYSTEM FOR PROVIDING INTERACTIVE SERVICES OVER A WIRELESS COMMUNICATIONS NETWORK

INTEL CORPORATION, Santa...

1. A system for providing an interactive application to one or more users via a wireless communications network, the system comprising:a wireless access device coupled to a server cooperating with a wireless communication network, the wireless access device configured to receive an interactive application delivered from the server over the wireless communication network, the wireless access device corresponding to at least one user of a plurality of users interacting with the interactive application over the wireless communication network;
the wireless access device is further configured to execute the interactive application in response to a request received over the wireless communication network or a request by the user of the wireless access device, wherein the interactive application executing on the wireless access device stores state information into a cache on the wireless access device, the cached state information indicating changes in state of one or more degrees of freedom associated with the interactive application on the wireless access device, wherein each degree of freedom includes multiple states;
the wireless access device is further configured to communicate the cached state information from the wireless access device to the server;
the wireless access device is further configured to receive, responsive to a request of any one of plurality of users, a cached communication from the server to facilitate interacting with the interactive application, wherein the cached communication includes cached state information indicating changes in state of one or more degrees of freedom associated with the plurality of users interacting with the interactive application, wherein each degree of freedom includes multiple states, wherein a maximum of the one or more degrees of freedom is determined by the server based on the interactive application being a specific game to enable the server to dynamically calculate an optimal frame size, and wherein a maximum latency for a fast-paced interactive application or a slow-paced interactive application is determined by the server based on the specific game being played to enable the server to calculate an allowable frames per second to and from the server; and
the wireless access device further configured to store, in a memory of the wireless access device, the cached state information received from the server.

US Pat. No. 10,245,504

MULTI-AXIS ROTATIONAL PUZZLE CUBE

1. A rotational puzzle cube comprising:a core unit being a hollow polyhedron and having
a first shell; and
a second shell;
the first shell and the second shell being connected together to form the core unit;
multiple first assembling plates each having an external face; and
multiple second assembling plates each having an exterior face;
multiple first operating assemblies rotatably and respectively assembled to the multiple first assembling plates of the core unit, and each one of the multiple first operating assemblies having
a first operating unit connected to the external face of a corresponding one of the multiple first assembling plates;
a snap rivet disposed within the core unit and connected to the first operating unit;
a blocking tube disposed within the core unit, and mounted around and stuck with the snap rivet of the first operating assembly;
a compression spring disposed within the core unit, mounted around the snap rivet of the first operating assembly, and having two opposite ends;
one of the two opposite ends of the compression spring abutting against the core unit; and
another one of the two opposite ends of the compression spring abutting against the blocking tube; and
multiple sliding plates assembled to the first operating unit and being slidable relative to the first operating unit; and
multiple second operating assemblies rotatably and respectively assembled to the multiple second assembling plates of the core unit, and
each one of the multiple second operating assemblies having
a second operating unit being a plate and connected to the exterior face of a corresponding one of the multiple second assembling plates;
a snap rivet disposed within the core unit and connected to the second operating unit;
a blocking tube disposed within the core unit, and mounted around and stuck with the snap rivet of the second operating assembly; and
multiple sliding plates assembled to the second operating unit and being slidable relative to the second operating unit;
each one of the multiple first operating units of the multiple first operating assemblies having
a polyhedral shell being a hollow polyhedron and having
multiple constructing plates;
an opening surrounded by the multiple constructing plates;
a connecting shank extending from an interior of the polyhedral shell and extending toward the opening of the polyhedral shell; and
multiple notches formed through the polyhedral shell and communicating with the opening; and
a guiding member disposed inside the polyhedral shell and having multiple troughs respectively aligned with the multiple notches and respectively abutting against the multiple constructing plates; wherein
the guiding member has a mounting tube mounted around the connecting shank;
the multiple troughs of the guiding member are connected to a peripheral face of the mounting tube and are disposed around the mounting tube at equi-angular intervals; and
the multiple sliding plates of each one of the first operating assemblies are respectively assembled in the multiple troughs of the guiding member and are respectively clamped by the multiple troughs and the multiple constructing plates of the polyhedral shell.

US Pat. No. 10,245,503

APPARATUS FOR PLAYING A GAME

1. An apparatus for playing a game, the apparatus comprising a three dimensional structure assembled from a plurality of interconnectable and disengageable construction elements, characterised in that each construction element is a shaped elongate body piece with two end mating faces or surfaces, each mating face having a connector to enable each construction element to connect to and disengage other like construction elements, and wherein the interconnection between two mating faces or surfaces is allowable in one orientation only and wherein the two connectors of each piece are transposed 180 degrees relative to each other, wherein the apparatus further comprises a minimum of two to four core elongate body pieces that create Celtic knotwork or weaving patterns in a three dimensional general plane, the four being; a straight (0 degrees) piece (A), a quadrant (90 degrees) piece (B), a U-bend (180 degrees) piece (C) and a loop (270 degrees) piece (D) as viewed from above, the front or side; where each piece has a side profile resembling a “stretched out half a sine wave/curve” which is stretched around each top profile in the three dimensional structure, the distance the side profile of a drop being equivalent to the diameter of the piece.

US Pat. No. 10,245,501

ADJUSTABLE BILLIARDS BRIDGE DEVICE

1. An adjustable billiards bridge device, the device comprising:a. a body having a first end and an opposing second end as well as a front side and an opposing rear side, the body having a central cue surface and the body further comprising a first body detent coupled to the front side at the first end and a second body detent coupled to the front side at the second end;
b. a first leg pivotally coupled to the first body detent on the front side at the first end of the body, the first leg having a first peripheral cue surface and the first leg configured to pivot horizontally relative to the body;
c. a second leg pivotally coupled to the second body detent on the front side at the second end of the body, the second leg having a second peripheral cue surface and the second leg configured to pivot horizontally relative to the body; and
d. a coupler positioned centrally on the body between the first end and the second end and protruding outwardly from the front side of the body in the same direction as the first body detent and the second body detent thereby blocking the first leg and second leg from rotating 360 degrees.

US Pat. No. 10,245,499

TOURING BINDING TO BE FITTED TO A GLIDING BOARD

Salewa Sport AG, Herisau...

1. Front unit of a touring binding, comprising:a bearing arrangement having a bearing element, the bearing element being designed to hold a touring shoe on the front unit on a counter-bearing portion of the touring shoe so as to be pivotable about a transverse axis extending transversely to a glide board longitudinal axis;
a release path being defined on the bearing arrangement, along which path the counter-bearing portion of the touring shoe is configured to exit the bearing arrangement;
a blocking portion designed to:
block a movement of the counter-bearing portion of the touring shoe along the release path when the front unit is in a blocked state; and
allow the movement of the counter-bearing portion of the touring shoe along the release path when the front unit is in a neutral state, wherein, when moving from the neutral state into the blocked state, the blocking portion performs a rotational movement about an axis of rotation of the blocking portion, which axis extends transversely to a glide board longitudinal axis.

US Pat. No. 10,245,498

LIGHTWEIGHT BALL GLOVE

1. A lightweight ball glove comprising: a back portion, said back portion comprising:a first plurality of lightweight layers, said first plurality of lightweight layers comprising:
a first inner lining layer;
a first outer surface layer; and
a first soft open-cell foam layer sandwiched between the first inner lining layer and the first outer surface layer; and
a shock cord tension system located on a back surface of the first soft open-cell foam layer, said shock cord tension system comprising:
a first plurality of loops located about a finger area of said lightweight ball glove, said first plurality of loops comprising:
a loop located on an outside portion of a pointer finger-palm joint of said lightweight ball glove; and
one or more loops located at another finger-palm joint of said lightweight ball glove;
an opening on an outside portion of a pinky-palm joint of said lightweight ball glove;
a cord routed into said opening, through said plurality of loops and back out said opening; and
a cordlock about said cord outside of said opening to provide an adjustable locking mechanism for holding tension on said cord;
a palm portion, said palm portion comprising a second plurality of lightweight layers, an outer edge of said palm portion fixedly coupled with an outer edge of said back portion to form the lightweight ball glove;
a web portion, said web portion fixedly coupled between a thumb and a pointer finger of said lightweight ball glove, said web portion comprising:
a mesh formed from monofilament yarns;
a surrounding frame fixedly coupled with a side and bottom portion of said mesh, said surrounding frame comprising said first plurality of lightweight layers; and
a bridge fixedly coupled with a top of said mesh; and
a cordage for lacing together a top portion of said pointer finger, a top portion of said thumb of said lightweight ball glove, and said bridge to form said lightweight ball glove.

US Pat. No. 10,245,497

APPARATUS FOR HAND PROTECTION AND METHOD THEREOF

WOD SOLUTIONS INC, Feast...

1. Apparatus for protection of a hand having a wrist, a plurality of fingers and a plurality of knuckles, comprising:a flexible sheet having a continuous top side and a bottom flat side opposite the top side, said flexible sheet extending from a first edge to a second edge along a length thereof, said flexible sheet having a plurality of sections including a first section adjacent to said first edge, a second section adjacent to said second edge, and a third section between said first section and said second section, so that along said length from said first edge to said second edge said plurality of sections are ordered said first section, said third section, and said second section;
an adhesive material on said bottom flat side of said flexible sheet;
a backing layer on said adhesive material and subsequently removed;
said first section includes a flat area that has a plurality of finger openings planar with said flat area and arranged in sequence along a width of said flexible sheet, said width perpendicular to said length, said length from said first edge to said second edge greater than said width, said third section between said finger openings and said second section;
said second section includes a slit extending from said second edge towards said first edge which separates said second section into a plurality of anchors of substantially equal size and that are adapted for wrapping around said wrist,
each of said openings are encircled by said flexible sheet in said first section so that, when said fingers are inserted into said openings, respectively, said fingers are encircled by said flexible sheet, topmost edges of said openings are between said first edge and bottom edges of said openings, and
said flexible sheet includes a flexible sheet portion, above said topmost edges of said openings and below said first edge, that covers said knuckles after removal of at least a portion of said backing layer, said topmost edges above said third section;
length of said first section is less than combined length of said second section and said third section.

US Pat. No. 10,245,495

TENNIS TRAINING DEVICE

1. Tennis training device, comprisinga support bar (5) supporting a ball (1) and swivelable between a first stop (8) and a second stop (9) at a base,
wherein the ball (1) is mounted at the free end of the support bar,characterised in thatthe ball (1) is mounted at a connecting member (20) which is releasably fixed at the free end of the support bar by a fix ng cans (20.2), whereinthe ball (1) ismounted at the connecting member (20) in such a way as to be movable in different directions bymeans of an elastic extension (1a) which protrudes in radial direction from the ball, andwhereina plate (20.3) is mounted at the connecting member (20) for supporting the ball (1).

US Pat. No. 10,245,494

TRICK BOARD TRAINING APPARATUS

1. An apparatus for use with a trick board in training a trick board rider, comprising:an apparatus base;
a first upright member connected to the apparatus base and a second upright member connected to the apparatus base, the first upright member in spaced-apart relationship from the second upright member, defining a training zone there between; and
a trick board suspension member for suspending the trick board within the training zone, the trick board suspension member having a first rotation mechanism for rotating the trick board about a first axis of rotation and a second rotation mechanism for rotating the trick board about a second axis of rotation, wherein the second axis of rotation is substantially perpendicular to the first axis of rotation when the first axis of rotation is substantially parallel to the ground,
whereby the trick board can be rotated about at least one of the first and second axes of rotation while remaining suspended.

US Pat. No. 10,245,493

TEE

1. A tee for supporting a ball, the tee comprising:a base defining an x-axis;
a vertical support extending from the base; the vertical support defining a z-axis; and
a ball support assembly adjustably secured to the vertical support; the ball support assembly defining a y-axis, the ball support assembly arranged and configured to releasably support a ball and release the ball upon contact during use;
a bat path adjuster bracket connected to the ball support assembly; wherein the bat path adjuster bracket is operatively connected to the vertical support with a connector plate, the bat path adjuster bracket including a first aperture and a first arched slot, a vertical adjuster extends through the first aperture to interconnect the bat path adjuster bracket and the connector plate, a first angle adjuster extends through the first arched slot to interconnect the bat path adjuster bracket and the connector plate, the vertical adjuster allowing selective vertical adjustment along the vertical support, the first angle adjuster allowing selective rotation of the bat path adjuster bracket with respect to the connector plate within the first arched slot;
wherein the x-axis and the y-axis define an xy-plane, the x-axis and the z-axis define a xz-plane, the y-axis and the z-axis define a yz-plane;
wherein the ball support assembly is adjustable along the z-axis by moving relative to the vertical support and adjustable 0 to 90 degrees within at least one plane selected from the group consisting of the xz-plane and the yz-plane.

US Pat. No. 10,245,492

BASKETBALL SHOOTING TRAINING DEVICE

OnlyNet LLC, Richmond, V...

1. A device for improving basketball shooting form, comprising:an elongated base plate, wherein the base plate has a first end and a second end;
a lower housing assembly secured to the base plate, wherein the lower housing assembly comprises a frame having a set of opposing walls and an apron member secured above the first end of the base plate;
an optical projection device maintained at least partially within the lower housing assembly;
an upper housing assembly secured around the optical projection device;
a finger strap secured to the lower housing assembly for securing to a finger of a user; and
a wrist strap secured to the lower housing assembly for securing to a wrist of the user.

US Pat. No. 10,245,491

INFLATABLE DOJO STRUCTURE

Scherba Industries, Inc.,...

1. An inflatable device configured to be used as a martial arts training device, said inflatable device comprising an inflatable structure and a plurality of inanimate interactive devices connected to said inflatable structure, said inflatable structure including a floor that is at least partially inflatable, a plurality of inflatable columns extending upwardly from said floor and a plurality of inflatable beams connected to a top or top portion of said columns, said plurality of inanimate interactive devices located on or above said floor and said plurality of inanimate interactive devices configured to be engagable by a person located on said floor of said inflatable structure, one of said plurality of inanimate interactive devices is an object in the form of a person or ninja or an inflatable in the form of a person or ninja, and at least one other of said plurality of inanimate interactive devices is selected from the group consisting of a target, an inflatable target, punching or kicking target, inflatable punching or kicking target, another object in the form of a person or ninja, another inflatable in the form of a person or ninja, an object in the form of a person or ninja with a target, and an inflatable in the form of a person or ninja with a target, a plurality of different shapes of said plurality of inanimate interactive devices is located on an interior of said inflatable structure, at least one of said plurality of inanimate interactive devices is located on said interior of said inflatable structure includes an object in the form of a person or ninja hanging upside-down and positioned above said floor, and at least one of said plurality of inanimate interactive devices includes an inflatable target having a disc shape or cylindrical shape and which is connected to at least one of said columns.

US Pat. No. 10,245,488

VIBRATION DAMPING BAT AND METHODS OF MAKING THE SAME

MIZUNO CORPORATION, Osak...

1. A bat comprising:a handle having a proximate end and a distal end;
a barrel having a hollow portion;
a first damping section comprising a first material, the first damping section being at least partially interposed between, and in contact with, a portion of the handle and a portion of an inner wall of the barrel; and
a second damping section comprising a second material, the second damping section being at least partially interposed between, and in contact with, a portion of the handle and a portion of the inner wall of the barrel,
wherein the first damping section is located nearer the distal end of the handle than the proximate end of the handle and the second damping section is located nearer the proximate end of the handle than the first damping section, and
wherein at least a portion of the first damping section or at least a portion of the second damping section prevents the handle from directly contacting the barrel when the bat is at rest.

US Pat. No. 10,245,487

ADJUSTABLE GOLF CLUB AND SYSTEM AND ASSOCIATED GOLF CLUB HEADS AND SHAFTS

Karsten Manufacturing Cor...

1. A golf club head comprising:a body defining a ball striking surface, a crown, a sole, a hosel, a heel, and a toe; and
an adjustment member engaged with the body and having a hosel adapter, wherein the hosel adapter comprises a first rotation inhibiting structure and an off-axis bore hole; a shaft adapter with a second rotation inhibiting structure that engages the first rotation inhibiting structure, a spherical member, an off-axis bore hole, and a shaft adapter axis, the spherical member of the shaft adapter operably connected to the hosel adapter and rotatable about the shaft adapter axis, and
wherein the body and adjustment member are structured such that the adjustment member independently adjusts a specific combination of a loft angle and a face angle, with the loft angle among a first plurality of positions and the face angle among a second plurality of positions wherein in response to the independent adjustment of the loft angle and the face angle, a parameter associated with the body remains substantially unchanged within a predetermined tolerance, wherein the parameter is one of the following: the golf club head's location of a center of gravity, a face center, or a sole contact point, wherein each location is measured from a hosel origin point located at an intersection of the shaft adapter axis and an uppermost edge the shaft adapter, wherein the off-axis bore hole engagement between the hosel adapter and shaft adapter allows for independent adjustment of the loft angle or the face angle and
further wherein when the parameter is the location of a center of gravity of the golf club head, and the predetermined tolerance for the location of the center of gravity is approximately 3 mm from a reference center of gravity determined before the independent adjustment of the loft angle and the face angle, and
wherein when the parameter is a location of the face center of the golf club head, and the predetermined tolerance for the location of the face center is approximately 3 mm from a reference face center determined before the independent adjustment of the loft angle and the face angle, and
wherein when the parameter is the sole contact point, the predetermined tolerance for the location of the sole contact point is 4 mm from a reference sole contact point determined before the independent adjustment of the loft angle and the face angle.

US Pat. No. 10,245,486

GOLF BAG HAVING HUB SHOULDER STRAP CONNECTOR FOR CONVERTING FROM TWO STRAPS TO SINGLE STRAP

Acushnet Company, Fairha...

1. A golf bag having dual shoulder straps that can be converted to a single shoulder strap, the bag comprising:an elongated tubular body for holding golf clubs; and
a shoulder strap assembly, the assembly comprising:
i) a first shoulder strap (A) having an upper connector webbing, a cushioned portion, and a lower connector webbing, the upper connector webbing being removably attached to the bag at a first bag attachment point, and the lower connector webbing being removably attached to the bag at a second bag attachment point;
ii) a second shoulder strap (B) having an upper connector webbing, a cushioned portion, and a lower connector webbing, the upper connector webbing being removably attached to the bag at a third bag attachment point, and the lower connector webbing being removably attached to the bag at a fourth bag attachment point;
iii) a hub connector base plate, the hub plate having a first set of diagonally opposed elevated slots so the first strap (A) can extend through the slots and the hub plate having a second set of diagonally opposed elevated slots so the second strap (B) can extend through the slots, each slot in the second set of diagonally opposed slots comprising leg segments that extend upwardly from the base plate, the leg segments connected by an upper horizontally-extending crossbar that defines a channel for strap B to be inserted therethrough, the channels being on a different plane than the base plate, where the upper crossbar has a cut-out portion for removing strap B from the slot, and wherein the straps cross over each other in the hub connector and form an X-shaped pattern when the first strap (A) is fitted over one shoulder and the second strap (B) is fitted over an opposing shoulder of a person carrying the bag.

US Pat. No. 10,245,485

GOLF CLUB HEAD HAVING A STRESS REDUCING FEATURE WITH APERTURE

Taylor Made Golf Company ...

1. A hollow golf club having a stress reducing feature with aperture comprising:(A) a shaft (200) having a proximal end (210) and a distal end (220);
(B) a grip (300) attached to the shaft proximal end (210); and
(C) a golf club head (400) attached to the shaft distal end (220) and having:
(i) a face (500) positioned at a front portion (402) of the golf club head (400) where the golf club head (400) impacts a golf ball, and wherein the face (400) includes a top edge height (TEH) and a lower edge height (LEH);
(ii) a sole (700) positioned at a bottom portion of the golf club head (400);
(iii) a crown (600) positioned at a top portion of the golf club head (400);
(iv) a skirt (800) positioned around a portion of a periphery of the golf club head (400) between the sole (700) and the crown (600), wherein the face (500), sole (700), crown (600), and skirt (800) define an outer shell that further defines a head volume, and wherein the golf club head (400) has a rear portion (404) opposite the face (500);
(v) a bore having a center that defines a shaft axis (SA) which intersects with a horizontal ground plane (GP) to define an origin point, wherein the bore is located at a heel side (406) of the golf club head (400) and receives the shaft distal end (220) for attachment to the golf club head (400), and wherein a toe side (408) of the golf club head (400) is located opposite of the heel side (406);
(vi) a center of gravity (CG) of the golf club head (400) located:
(a) vertically toward the crown (600) of the golf club head (400) from the origin point a distance Ycg;
(b) horizontally from the origin point toward the toe side (408) of the golf club head (400) a distance Xcg that is generally parallel to the face (500) and the ground plane (GP); and
(c) a distance Zcg from the origin toward the rear portion (404) in a direction generally orthogonal to the vertical direction used to measure Ycg and generally orthogonal to the horizontal direction used to measure Xcg;
(vii) a stress reducing feature (1000) including a sole located SRF (1300) located at least partially on the sole (700), wherein:
(a) the sole located SRF (1300) has a SSRF length (1310) between a SSRF toe-most point (1312) and a SSRF heel-most point (1316), a SSRF leading edge (1320) having a SSRF leading edge offset (1322), a SSRF trailing edge (1330), a SSRF volume, a SSRF width (1340), and a SSRF depth (1350), wherein the sole located SRF (1300) has at least one of (a) a portion of the SSRF width (1340) is at least ten percent of the Zcg distance, and (b) a portion of the SSRF depth (1350) is at least ten percent of the Ycg distance; and
(b) the sole located SRF (1300) has a SSRF aperture (1400) recessed from the sole (700) and extending through the outer shell, wherein the SSRF aperture (1400) has a SSRF aperture length (1410) between a SSRF aperture toe-most point (1412) and a SSRF aperture heel-most point (1416), and a SSRF aperture width (1440), wherein the SSRF aperture length (1410) is at least fifty percent of the Xcg distance; and
(c) the golf club head (400) has a characteristic time of at least 220 microseconds.

US Pat. No. 10,245,484

IRON TYPE GOLF CLUB HEAD

Taylor Made Golf Company,...

1. An iron-type golf club head comprising:a heel,
a toe,
a sole,
a top-line of the iron-type club head,
a striking face having a forward-facing ball-striking surface, a rearward-facing surface, and an ideal striking location; and
a perimeter weight surrounding the striking face;
wherein the striking face has a supported region supported by the perimeter weight and an unsupported region, with the ideal striking location lying within the unsupported region, the unsupported region having a thickness that varies in a heel-toe direction;
wherein a heel portion of the unsupported region of the striking face is located on a heel side of an imaginary vertical plane that extends perpendicularly to the ground plane and that contains an imaginary line that extends in a direction normal to the striking face at the ideal striking location when the clubhead is in the normal address position, and wherein a toe portion of the unsupported region of the face is located on a toe side of the imaginary plane;
wherein the clubhead has a relative coefficient of restitution of at least ?0.030; and
wherein the following two inequalities are satisfied:
SATOE>SAHEEL,  (1)
 and
[(?n=1NEntn3)÷N]÷[(?m=1MEmtm3)÷M]>1.20;  (2);
wherein:
SATOE is defined as the surface area of the toe portion of the unsupported region,
SAHEEL is defined as the surface area of the heel portion of the unsupported region,
En and tn are the effective Young's Modulus value and the thickness, respectively, for the nth cross-section of the toe portion of the unsupported region of the striking face,
Em and tm are the effective Young's Modulus value and the thickness, respectively, for the mth cross-section of the heel portion of the unsupported region of the striking face,
and N and M have values determined by discretizing SATOE and SAHEEL, respectively, into 1 mm×1 mm sections;
wherein a hitting region of the unsupported region of the striking face lies within an imaginary circle drawn on the ball-striking surface, with the imaginary circle having a radius of 20 mm and having a center located at the ideal striking location.

US Pat. No. 10,245,483

GOLF CLUB HEAD

BRIDGESTONE SPORTS CO., L...

1. A golf club head comprising:a face including a ball-striking surface;
a sole defining a bottom of the golf club head;
an attachment member;
an attachment part to which the attachment member is attachable; and
a rib formed on an internal surface of the golf club head,
wherein the rib is spaced apart from the attachment part, and
wherein the rib extends so as to wholly surround the attachment part.

US Pat. No. 10,245,482

GOLF CLUB HEAD

SUMITOMO RUBBER INDUSTRIE...

1. A golf club head comprising:a sole;
a crown;
a toe;
a heel opposite the toe;
a strike face generally bounded by a face perimeter edge, the strike face comprising a geometric center that is associated with a first coefficient of restitution value;
a rear portion;
a substantially enclosed interior cavity at least partially delimited by the sole, the crown, the strike face, and the rear portion; and
at least one rib having a first portion secured to the strike face and a second portion secured to the crown, the at least one rib being structured and positioned such that a location on the strike face laterally spaced toe-ward from the geometric center by no less than 0.4 in is associated with a second coefficient of restitution value that is no less than 0.825 and greater than the first coefficient of restitution value.

US Pat. No. 10,245,481

GOLF CLUB HEAD

Acushnet Compnay, Fairha...

1. A golf club head comprising:a body having a face, a sole portion, a crown portion and a skirt portion joining the face, sole portion and crown portion;
a hollow golf club interior within the body;
an exterior surface provided opposite the hollow golf club interior;
a plurality of depressions provided on a first portion of the exterior surface of the body;
wherein the plurality of depressions have a depth of about 0.5 mm to about 2 mm, have a width of about 6 mm to about 20 mm and have a minimum landing surface spacing of about 0.5 mm to about 7 mm between depressions on the exterior surface, and
wherein the first portion is provided on at least one of a sole portion or crown portion of the body and further comprises a setback from the face portion of the body, the setback being free of depressions, and wherein the setback has a width of about 6 mm to about 14 mm.

US Pat. No. 10,245,480

GOLF CLUB HEAD OR OTHER BALL STRIKING DEVICE HAVING IMPACT-INFLUENCING BODY FEATURES

NIKE, Inc., Beaverton, O...

1. A golf club head comprising:a face having a ball striking surface configured for striking a ball;
a body connected to the face and extending rearwardly from the face, wherein the body has a crown, a sole, a heel, a toe, and a rear opposite the face;
a channel located on the body and extending across a portion of the sole, the channel being inwardly recessed from an exterior surface of the sole, wherein the channel has a width defined in a front-to-rear direction, and wherein the width of the channel is greatest proximate the exterior surface of the sole and decreases inwardly from the exterior surface; and
an insert mounted within the channel and engaging the channel, wherein the insert has a width defined in the front-to-rear direction, and wherein the width of the insert is greatest at an outer surface of the insert and decreases inwardly from the outer surface of the insert,
wherein the body and the face combine to define an internal cavity, and wherein the channel creates a raised portion on an interior surface of the body, and
wherein the channel includes a slot extending into the internal cavity, and wherein a portion of the insert is received within the slot.

US Pat. No. 10,245,479

MULTI-MATERIAL GOLF CLUB HEAD

Acushnet Company, Fairha...

1. A golf club head comprising:a striking face portion located at a frontal portion of said golf club head; and
a body portion attached to an aft portion of said striking face portion further comprising a crown portion and a sole portion;
wherein at least one of said crown portion or said sole portion further comprises a base layer and a lightweight cover layer;
said base layer further comprises a plurality of cutouts, and
said lightweight cover layer has an Internal Exposure Percentage of between about 25% to about 45%; and
wherein said golf club head produces a sound that has a Critical Time Tcritical of greater than about 0.01 seconds and less than about 0.02 seconds; said Critical Time Tcritical is defined as the amount of time it take said sound to oscillate from a peak amplitude Apeak to a point of 10% of said peak amplitude Apeak.

US Pat. No. 10,245,476

GOLF CLUB FACE INSERT

Callaway Golf Company, C...

9. A putter comprising:a body comprising a top portion, a sole portion, a toe side, a heel side, a rear side, and a face side with a recess; and
a face insert comprising a striking plate having a first average thickness and a backing portion having a second average thickness,
wherein the face insert is disposed within the recess so that at least a portion of the striking plate is exposed,
wherein a horizontal y-axis extends in a heel side to toe side direction parallel with the face side, a vertical z-axis extends perpendicular to the y-axis from the sole portion to the top portion, and a horizontal x-axis extends perpendicular to both the y- and z-axes from the face side to the rear side,
wherein the striking plate comprises a base portion, a first set of hinge features disposed at a middle section of the striking plate, a second set of hinge features disposed at a heel side of the striking plate, and third set of hinge features disposed at a toe side of the striking plate,
wherein the first set of hinge features comprises a plurality of first hinge features, each extending towards the sole portion parallel with the z-axis,
wherein the second set of hinge features comprises a plurality of second hinge features, each extending towards the middle section at a first angle of no less than 10° and no more than 75° with respect to the y-axis,
wherein the third set of hinge features comprises a plurality of third hinge features, each extending towards the middle section at a second angle of no less than 10° and no more than 75° with respect to the y-axis,
wherein each of the hinge features of the first, second, and third pluralities of hinge features comprises a stem portion that extends from the base portion at a stem angle of no more than 90 degrees with respect to the base portion, and a tab portion that is spaced from the base portion by the stem portion and extends from the stem portion approximately parallel with the base portion without making contact with the base portion, and
wherein each tab portion is at least partially disposed over a through-hole extending through the striking plate.

US Pat. No. 10,245,474

GOLF CLUB HEAD OR OTHER BALL STRIKING DEVICE HAVING IMPACT-INFLUENCING BODY FEATURES

Karsten Manufacturing Cor...

1. A golf club head comprising:a face having a striking surface configured for striking a ball,
an upper edge, a lower edge, a heel edge, and a toe edge;
a body connected to the face and extending rearwardly from the face,
the body having a crown, a sole, a heel side, a toe side, and a flange that forms a portion of the striking surface;
wherein the flange of the body and the face are welded at a joint to form an interior cavity and the upper edge, the lower edge, the heel edge, and the toe edge of the face are defined by the joint;
wherein the face has a first region having a first thickness, a second region having a second thickness, a third region having a third thickness, a fourth region having a fourth thickness, a fifth region having a fifth thickness; and
wherein the first region is positioned in a center region of the face,
wherein the center region has rectangular shape with rounded corners,
wherein the center region has a width in a range of 34 mm to 42 mm and a height within a range of 15 mm to 19 mm,
wherein the first thickness is a uniform thickness,
the second region is positioned on the toe side,
the third region is positioned on the heel side,
the fourth region is positioned between the first region and the upper edge of the face, and
the fifth region is positioned between the first region and the lower edge of the face;
wherein a toe side transitional region is positioned between toe side boundaries of the first region, the fourth region, the fifth region and a heel side boundary of the second region, wherein a heel side transitional region is positioned between heel side boundaries of the first region, the fourth region, the fifth region and a toe side boundary of the third region,
wherein the toe side transitional region and the heel side transition region have a variable thickness from boundaries with the first region, the fourth region, and the fifth region to blend into the thickness of the second and third regions, respectively,
wherein the fourth thickness has a variable thickness with a linear slope that decreases in thickness from the first thickness to the upper edge of the face at the joint and the fifth thickness has a variable thickness that that decreases with a linear slope from the first thickness to the lower edge of the face at the joint;
wherein the flange has a sixth thickness defined by a thickness at the heel edge of the joint,
wherein the sixth thickness is greater than the second thickness and the third thickness; and
wherein the flange does not extend inward beyond the joint.

US Pat. No. 10,245,472

AUTOMATIC ANTI-BRIDGING DEVICE FOR USE WITH A BALL WASHER

1. An apparatus comprising:a base portion;
a standing portion attached to the base portion, wherein the standing portion is oriented in a vertical direction and generally perpendicular to a horizontal plane defined by the base portion;
a motor having a rotatable shaft, a linkage connected to the rotatable shaft, and a bumper connected to the linkage at a location removed from the rotatable shaft; and
a tubular member connected to the standing portion and oriented generally perpendicular to and spaced from the horizontal plane formed by the base portion, said tubular member having an internal diameter that is generally free of obstructions to facilitate passage of spherical objects through said tubular member.

US Pat. No. 10,245,469

GOLF BALL AERODYNAMIC CONFIGURATION

Acushnet Company, Fairha...

1. A golf ball comprising an outer surface with at least two dimple structures, the dimple structures having an annular conical shaped base having a center with a dimple formed therein, wherein the annular conical shaped base of the dimples are non-polygonal, the dimples having an edge angle of 5° to 15° and further comprising at least one valley formed by the conical shaped bases of the two dimple structures, and wherein the dimples have a diameter ranging from about 0.060 inches to about 0.340 inches.

US Pat. No. 10,245,467

PISTON CONFIGURATIONS FOR PNEUMATIC POGO STICK

Vurtego, LLC, Mission Vi...

1. A pogo stick comprising:a housing having a first end and a second end;
a piston disposed within the housing, such that there is an upper confined space between the piston and the first end of the housing; and
a sliding shaft at least partially disposed within the housing, said sliding shaft connected to the piston and extending from the second end of the housing;
wherein the piston comprises:
an upper rim;
a lower surface;
a cylindrical piston body extending between the upper rim and the lower surface; and
a hollowed out volume of space between the upper rim and the lower surface and within the piston body to form a concave structure, the lower surface enclosing a lower end of the hollowed out volume of space;
wherein the upper rim of the piston defines an opening into the hollowed out volume of space facing the first end of the housing such that the hollowed out volume of space within the piston body is in fluid communication with the upper confined space;
wherein a total internal air volume of the housing includes the hollowed out volume of space at both a maximum extension of the piston and at a maximum compression of the piston to reduce a compression ratio of the total internal volume of the housing.

US Pat. No. 10,245,466

FOOT STRETCHING AND STRENGTHENING APPARATUS

1. An apparatus for stretching and strengthening the forefoot of a user, comprising:a pair of parallel leg members having first and second ends, wherein each lea member is a hollow tube having a cross bore at each first and second end;
a curved barrel bridging the pair of leg members and positioned intermediate the first and second end of each leg member, the barrel providing a support for the arch of a user's forefoot for flexing and strengthening the forefoot over the barrel; and
a removable elastic band positionable over the leg members intermediate the first end and the barrel to hold the toes of the user's forefoot over the barrel during flexing of the foot, further comprising a pair of extenders, each extender adapted to fit within the hollow tube and extend therefrom, and wherein each of the extenders is sized to fit within one of the cross bores.

US Pat. No. 10,245,464

SQUAT RACK FOR GROUP FITNESS CLASSES

1. A stackable squat rack designed for storability and mobility, comprising a pair of vertical rack members angled on an incline from a vertical position and connected via a crossbar; a pair of vertical support members each connected to a respective vertical rack member of the pair of vertical rack members, the pair of vertical support members configured to support the pair of vertical rack members; a pair of base members connected to each other via a floorbar, said pair of base members adapted to engage a floor surface, said pair of base members each connected to a respective vertical rack member of said pair of vertical rack members and to a respective vertical support member of said pair of vertical support members; a pair of horizontal support members each connected to a respective portion of said pair of vertical support members at one end and to a respective base member of said pair of base members at another end; a plurality of bar supports boated on the pair of vertical support members and said pair of horizontal support members; and two wheels connected to an end of said pair of base members, wherein each of the two wheels are connected to a respective base member of the pair of base members, wherein the pair of base members are angled such that the stackable squat rack is narrower at its rear than its front to allow the stackable squat rack to fit into another stackable squat rack of similar configuration for storage.

US Pat. No. 10,245,463

METHOD AND SYSTEM FOR AN EXERCISE DEVICE

Custom Product Innovation...

1. An exercise device comprising:a flat base comprising a first end and an opposing second end, said flat base configured to engage a flat exercise surface;
a pair of opposing sidewalls extending away from said flat base;
an arcuate upper surface extending between a first edge of said first end and a second edge of said opposing second end between said pair of opposing sidewalls, a first angle defined between said flat base and said upper surface proximate said first end, a second angle defined between said flat base and said upper surface proximate said opposing second end; and
a first coccyx cutout in said upper surface proximate said first end and extending to said first edge, and a second coccyx cutout in said upper surface proximate said opposing second end and extending to said second edge, wherein said first coccyx cutout extends completely through said exercise device and said second coccyx cutout extends only partially through said exercise device.

US Pat. No. 10,245,461

STRENGTH TRAINING SYSTEM AND METHOD OF USING SAME

1. An exercise system comprising:a first stationary support member having a lower portion and an upper portion, the upper portion of the first stationary support member being at an acute angle relative to the lower portion of the first stationary support member;
a second stationary support member having a lower portion and an upper portion, the upper portion of the second stationary support member being at an acute angle relative to the lower portion of the second stationary support member;
a first rotatable support member configured to rotate about a first axis between a first position wherein the first rotatable support member is generally adjacent to the upper portion of the first stationary support member and a second position wherein the first rotatable support member is generally adjacent to the lower portion of the first stationary support member;
a second rotatable support member configured to rotate about a second axis between a first position wherein the second rotatable support member is generally adjacent to the upper portion of the second stationary support member and a second position wherein the first rotatable support member is generally adjacent to the lower portion of the first stationary support member;
a first carriage member translatable along at least a portion of the first rotatable support member;
a second carriage member translatable along at least a portion of the second rotatable support member; and
a barbell coupled with the first and second carriage members.

US Pat. No. 10,245,458

MUSCLE TRAINING METHOD AND MUSCLE TRAINING SYSTEM

KAATSU JAPAN CO., LTD., ...

1. A muscle training method, comprising the following steps that are repeated alternately to perform training of a muscle of a user:a pressuring and exercise step of winding a belt around an arm of the user, the muscle being in the arm of the user, and applying a specific pressure thereto so as to restrict blood circulation to the muscle without stopping the blood circulation, and having the user perform a load-applied exercise to apply a load of specific weight to the muscle of the user; and
an exercise stopping step of having the user stop the load-applied exercise while continuously applying the specific pressure to the user,
wherein the load-applied exercise is a one-arm curl exercise which is performed by the arm of the user;
wherein
the specific weight is set at 20-30% of a maximum weight necessary for the user to exert a maximum muscle force,
wherein the pressuring and exercise step is performed three times or more including a first pressuring and exercise step, a second pressuring and exercise step, and a third pressuring and exercise step, wherein a number of the load-applied exercise performed in the second pressuring and exercise step is set at ½ or less of the number of the load-applied exercise performed in the first pressuring and exercise step, and a number of the load-applied exercise performed in the third pressuring and exercise step is set at ½ or less of a number of the load-applied exercise performed in the second pressuring and exercise step,
wherein a number of the load-applied exercise performed in the first pressuring and exercise step is set at 25 to 30,
wherein, in the exercise stopping step, a stopping duration of the load-applied exercise is set at 10 to 20 seconds,
wherein the muscle training method further comprises a pressure setting step to set the specific pressure,
wherein the pressure setting step comprises an attachment step, in which the belt is wound around the arm of the user for attachment with a specific attachment pressure, a pressurization step, in which pressure higher than the specific attachment pressure is applied to the user, and a depressurization step, in which the pressure applied in the pressurization step is removed to return to the specific attachment pressure, and
wherein the pressurization step and the depressurization step are performed alternately a plurality of times while setting a value of pressure in a given pressurization step larger than a value of pressure in a preceding pressurization step compared to the given pressurization step, and a pressure applied when a color of a palm of the user turns red or reddish brown in the pressurization step is set as the specific pressure.

US Pat. No. 10,245,457

TRAMPOLINE ASSEMBLY HAVING ADJUSTABLE RESILIENT MEMBERS

1. A trampoline assembly comprising:a trampoline bed;
a trampoline frame that supports the trampoline bed; and
a plurality of spaced apart, resilient members that are attached to and extend substantially between the trampoline bed and the trampoline frame to maintain the trampoline bed in tension, wherein at least one of the plurality of spaced apart, resilient members is an adjustable resilient member that can be selectively adjusted while simultaneously connected to both the trampoline frame and the trampoline bed to selectively adjust the tension of the trampoline bed; and wherein the adjustable resilient member includes a resilient assembly, wherein the resilient assembly includes a single spring, a first plug that is fixedly secured to the single spring, and a second plug that is fixedly secured to the single spring, the second plug being spaced apart from the first plug, a first connector that connects the resilient assembly to the trampoline bed, the first connector including a first externally threaded surface that is threaded into the first plug, and a second connector that connects the resilient assembly to the trampoline frame, the second connector including a second externally threaded surface that is threaded into the second plug, wherein threads of the first externally threaded surface are opposite from threads of the second externally threaded surface such that one of the first externally threaded surface and the second externally threaded surface includes right-hand threads and the other of the first externally threaded surface and the second externally threaded surface includes left-hand threads; wherein the resilient assembly is rotatable (i) in a first rotational direction relative to the first connector and the second connector while the adjustable resilient member is simultaneously connected to both the trampoline frame and the trampoline bed to increase the tension of the trampoline bed, and (ii) in a second rotational direction relative to the first connector and the second connector while the adjustable resilient member is simultaneously connected to both the trampoline frame and the trampoline bed to decrease the tension of the trampoline bed; wherein threads of the first externally threaded surface have a differently spaced pitch than threads of the second externally threaded surface.

US Pat. No. 10,245,453

SAFETY AIRBAG SYSTEM

1. An airbag device to cushion the free fall of a subject from an elevated height comprising:an inflatable base bag capable of sustaining an air pressure;
an inflatable structure comprised of a plurality of individual inflatable members, each comprising:
a wall with an annular cross-section; a top first end that is closed; and
a second end opposite the first end,
wherein the second end is coupled to an exterior upper surface of the base bag and is in fluid communication with the base bag,
wherein a space is located between each of the individual inflatable members and the other inflatable members such that the individual inflatable members do not touch and are not in direct fluid communication with the other individual inflatable members;
a net directly attached by net fasteners to a top portion of the inflatable structure, the net comprising:
a first set of frame members;
a second set of frame members oriented transverse to the first set of frame members;
and
wherein the first set of frame members are coupled to the second set of frame members by a plurality of knots and form a lattice having a plurality of open cells adapted to decelerate and support the subject from free fall; and
a top cover attached indirectly to the base bag, the top cover having a top sheet and side sheets that substantially cover and enclose the inflatable structure, while not being directly attached by fasteners to the net or the inflatable structure.

US Pat. No. 10,245,452

APPARATUS FOR SUSPENDING A LOAD ON A ROPE

TAZ, Saint Vincent de Me...

1. An apparatus for suspending a load on a suspension rope, comprising:a body (3) provided with a means (19, 20) for attaching the load and provided with a stationary member (6) and with a pivotal rocker arm member (7) between which the rope (2) passes and which are capable of immobilizing the body along the rope (2) when said body tilts in a direction determined by the load, wherein the rope comprises a taut upper strand (25), an intermediate portion (26), and a loose strand (27), said body also being provided with a stationary abutment (22) and with an unlocking lever (14) mounted pivotably on this body, said unlocking lever being capable of acting on the pivotal rocker arm member (7) in order to cause the pivotal rocker arm member (7) to pivot with respect to the body (3) as far as said abutment (22) and in order to cause said body (3) to tilt in the opposite direction when the rocker arm member (7) bears against said abutment (22), wherein the rocker arm member (7) has a pinching part (10) located facing a pinching part (9) of the stationary member and a bearing part (12) remote from its pinching part in such a manner that the intermediate portion (26) of the rope extends through a gap (11) separating said pinching parts and in front of said bearing part; wherein said means (19, 20) for attaching the load is located on the side of the stationary member relative to the rope and on the side of the bearing part of the rocker arm member relative to said gap; such that, through the effect of the suspended load, said intermediate portion of the rope is diverted relative to the taut upper strand of the rope and acts on said bearing part (12) of the rocker arm member in the direction that tends to bring the pinching parts closer together, in such a manner as to produce a local pinching effect on the suspension rope between these pinching parts (9, 10); wherein the pinching parts are held together irrespective of whether the loose strand of the rope is taut or loose; wherein said abutment (22) for the rocker arm member limits the gap (11) between said pinching parts (9, 10) to a maximum separation, wherein, in a first phase of releasing the rope, said unlocking lever (14) is configured to act on the rocker arm member (7) in the direction of the distancing of said pinching parts (9, 10) when said unlocking lever (14) is pivoted relative to the body in the opposite direction from the pivoting direction of the rocker arm member (7); and wherein, in a second phase of releasing the rope, said unlocking lever (14) is configured to cause the body to tilt in the direction of the reduction of the deviation of the intermediate portion (26) of the suspension rope relative to said taut strand (25) when the rocker arm member bears against said abutment (22) through the effect of said unlocking lever.

US Pat. No. 10,245,449

SYSTEMS AND METHODS FOR COUPLING AN ULTRASOUND SOURCE TO TISSUE

Guided Therapy Systems, L...

1. A system comprising:an ultrasound source comprising a transducer;
an acoustically transparent standoff acoustically coupled to the transducer;
an acoustic window at a surface of the standoff, the acoustic window having a thickness of an integer multiple of half wavelength of ultrasound energy emitted by the ultrasound source; and
an ultrasound controller coupled to the transducer, the ultrasound controller configured to cause the transducer to emit the ultrasound energy, the ultrasound energy being frequency swept over time, the ultrasound controller monitoring a coupling status of the ultrasound source by measuring at least a portion of the ultrasound energy that is reflected by the acoustic window.

US Pat. No. 10,245,448

PARTICLE BEAM MONITORING SYSTEMS AND METHODS

Varian Medical Systems Pa...

1. A radiation system comprising:a primary particle beam generator that generates a primary particle beam; and
a monitoring component that monitors the primary particle beam, wherein the monitoring component comprises:
a reaction component configured as an external window through which the primary particle beam exits the radiation system, wherein the reaction component is impacted by the primary particle beam and results of an impact include creation of secondary photons;
a detection component that detects a secondary photon characteristic; and
a primary particle beam characteristic determination component that determines a primary particle beam characteristic based upon the secondary photon characteristic.

US Pat. No. 10,245,447

MAGNETIC RESONANCE IMAGING GUIDED BRACHYTHERAPY WITH DISPLAYING THE CATHETER PLACEMENT POSITION

Koninklijke Philips N.V.,...

1. A medical apparatus (200, 300, 400) comprising:A magnetic resonance imaging system (202) for acquiring magnetic resonance data (244, 250) from an imaging zone (208);
a display (270, 501) for displaying images (252, 500);
a processor (228) for controlling the medical apparatus;
a memory (234) for storing machine executable instructions for execution by the processor,wherein execution of the instructions causes the processor to receive a brachytherapy treatment plan (240) for treating a subject (210),wherein execution of the instructions further causes the processor to acquire (100) planning magnetic resonance data (244) using the magnetic resonance imaging system,wherein execution of the instructions further causes the processor to calculate (102) a catheter placement position (246, 900, 902) and a catheter control command (248) for each of the multiple brachytherapy catheters using the brachytherapy treatment plan and the planning magnetic resonance data, wherein the catheter control command is descriptive of locations and dwell times for the locations for one of the multiple brachytherapy catheters,wherein execution of the instructions causes the processor, for each catheter placement position, to repeatedly:acquire (106) guidance magnetic resonance data (250);
reconstruct (108) an image (252, 500) from the guidance magnetic resonance data;
display (110) the image on the display;
display (112) the catheter placement position on the image;
receive (114) a catheter inserted signal from a user interface;
segment (116) the image to determine the catheter placement position after receiving the catheter inserted signal;
recalculate (116) the catheter placement positions for each remaining catheter placement position after receiving the catheter inserted signal; and
recalculate (116) the catheter control command for the multiple catheters after receiving the catheter inserted signal.

US Pat. No. 10,245,446

MARKER-FLANGE FOR MRI-GUIDED BRACHYTHERAPY

UNIVERSITY OF IOWA RESEAR...

1. A marker-flange for use with a brachytherapy applicator, comprising:a flange body having a first face and a second face, with a hollow chamber positioned in the flange body between the first and second faces;
a cavity comprising a first cavity opening on the first face and a second cavity opening on the second face, the cavity extending through the flange body and dimensioned to receive a tandem in a brachytherapy applicator in a press-fit connection;
a port comprising a port opening positioned on one of the first and second faces of the flange body, the port being configured to communicate with the hollow chamber; and
a sealing agent contained within the port opening, the sealing agent providing an air-tight seal between the hollow chamber and an external environment outside the flange body.

US Pat. No. 10,245,444

PORTABLE NON-INVASIVE DEVICES FOR INTEGRATIVE MEDICINE AND HOLISTIC HEALING

1. A portable, non-invasive therapeutic device adapted for treatment comprising:a) an energy-emitting plate with a central opening defining a front portion of the device and a wall extending outwardly therefrom and enclosing an hollow interior space behind an the inner surface of the energy-emitting plate, wherein the energy-emitting plate is coated with mineral ore adapted to emit a therapeutically effective level of light energy;
b) a rivet comprised of germanium and located at an approximately center point on the energy-emitting plate:
c) a heating element disposed in the hollow interior space behind the inner surface of the energy-emitting plate and attached to an the inner surface of the energy-emitting plate;
and
d) a power circuit in electrical connection with a microprocessor, which is further in electrical connection with a heater line/heat control circuit, a temperature sensor circuit, a digital display circuit and a switch control circuit, wherein the heater line/heat control circuit is, in turn, in electrical connection with the heating element;
wherein the microprocessor is programmed to cause the heat control circuit to pulse heat the heating element, and in turn, the energy-emitting plate, on and off along a person's body; and wherein the microprocessor further sends digital data to and in digital communications with the digital display circuit and the switch control circuit; and
wherein the energy-emitting plate and the rivet are configured to provide light energy to a subject's body when placed over at least one or more sensitive points or portions of the subject's body.

US Pat. No. 10,245,443

RED LIGHT IMPLANTS FOR TREATING OSTEOPOROSIS

DePuy Synthes Products, I...

1. A method of treating a patient, involvinga) injecting a flowable material into a cancellous bone region of a bone, wherein the material is adapted to facilitate tissue regeneration, and
b) irradiating the cancellous bone region with an effective amount of NIR/red light effective to stimulate bone repair.

US Pat. No. 10,245,442

APPARATUS FOR RELAXING RESPIRATORY TRACT AND BRONCHIAL TUBE

COLOR SEVEN CO., LTD., S...

1. A necklace shape apparatus for treating a respiratory ailment, comprising:a color light therapy device (110) that relaxes a treatment area by emitting color light in a wavelength band of visible light through a color light emitting protrusion (113) formed protruding from a rear surface of a body (111) and positioned in a front of the treatment area for a predetermined duration with a predetermined emitting pattern and causing the treatment area to secrete a material that relaxes the treatment area when an operation button (112) installed on a front surface of the body (111) is pushed and an operation of the color light therapy device (110) is started; and
a pair of neck bends (120) that extend from both side surfaces of the color light therapy device (110), elastically gird a perimeter above the treatment area allowing the rear surface of the body (111) to be placed in front of the treatment area, and having two ends at which pressing protrusions (121) press against an area above and behind the treatment area, wherein the pair of neck bends (120) extend from the both side surfaces of the color light therapy device (110), and a battery (111a) and a printed circuit board (PCB) (111b) are installed inside the color light therapy device (110), and
wherein the color light therapy device (110) comprises:
the body (111) in which a controller (111c) that outputs a color light emitting signal for emitting color light for a predetermined duration with a predetermined emitting pattern according to an operation start signal and at least one of any one of a light emitting diode (LED), an organic LED (OLED), a laser diode (LD), and a three color LED that is allowed to generate various color light as a light source (111d) that is turned on according to the color light emitting signal and emits color light of a wavelength band of visible light for relaxing the treatment area are mounted on the PCB (111b);
an operation button (112) that is installed on the front surface of the body (111) and alternately outputs an operation start signal and an operation end signal every time the operation button (112) is pushed;
the color light emitting protrusion (113) protruding from the rear surface of the body (111) and has a leading end in which a light emitting port (113a) is formed for concentrating color light emitted from the light source (111d) and emitting the concentrated color light to the outside;
a light filter (114) that is installed inside the color light emitting protrusion (113), filters and focuses color light emitted from the light source (111d) and emits the color light through the light emitting port (113a); and
a vibration detection signal generator (115) that is installed inside the body (111) and, when the operation end signal is output and a vibration detector (115a) exposed from the rear surface of the body (111) detects vibrations greater than a predetermined reference value, outputs a vibration detection signal to transmit the vibration detection signal to the controller (111c).

US Pat. No. 10,245,441

IMPLANTABLE DEVICE WITH OPTICAL LEAD

MEDTRONIC, INC., Minneap...

1. An implantable active medical device system comprising:an active medical device;
a lead extending between a proximal portion electrically coupled to the active medical device and a distal end portion configured to emit light, the distal end portion comprising:
a solid state light source disposed within a light transmissive ring element, the light transmissive ring element forming an exterior segment of the distal end portion, the light transmissive ring element defining at least a portion of a hermetic cavity;
wherein the light transmissive ring element is hermetically bonded to an electrode ring element and the electrode ring element forming an exterior segment of the distal end portion.

US Pat. No. 10,245,440

TISSUE TREATMENT APPARATUS AND SYSTEMS WITH PAIN MITIGATION AND METHODS FOR MITIGATING PAIN DURING TISSUE TREATMENTS

SOLTA MEDICAL, INC., Hay...

1. A method of operating a tissue treatment apparatus to transcutaneously treat tissue located beneath a skin surface with electromagnetic energy delivered from a treatment electrode, the method comprising:contacting a first portion of a surface of the treatment electrode with the skin surface, wherein the first portion of the surface of the treatment electrode is exposed through an opening located inside an inner edge of a tip frame;
covering a second portion of the surface of the treatment electrode with the tip frame, wherein the second portion of the surface of the treatment electrode is located between an outer peripheral edge of the tip frame and the inner edge of the opening in the tip frame; and
while maintaining contact between the first portion of the surface of the treatment electrode and the skin surface, transcutaneously delivering the electromagnetic energy from the first portion of the surface of the treatment electrode through the skin surface to the tissue,
wherein the tip frame is composed of an electrically-insulating material.

US Pat. No. 10,245,439

AESTHETIC METHOD OF BIOLOGICAL STRUCTURE TREATMENT BY MAGNETIC FIELD

MEDICAL TECHNOLOGIES CZ A...

1. A method for treating pelvic floor issues of a patient using a time-varying magnetic field applied to a pelvic floor of the patient wherein the time-varying magnetic field is applied to a muscle and/or a nerve innervating the muscle within a body region between coccyx and pubic bone of the patient in order to cause a contraction of the muscle in the pelvic floor, the magnetic field generated by a treatment device which includes a switching device, an energy storage device and a magnetic field generating device, comprising:a) charging the energy storage device;
b) switching the switching device on for a first time period having a duration in a range of 3 to 1000 ?s and enabling a current discharge from the energy storage device to the magnetic field generating device in order to generate an impulse of the time-varying magnetic field and applying the impulse of the time-varying magnetic field to the patient;
c) switching the switching device off for a second time period at least four times longer than the first time period and generating no magnetic field by the magnetic field generating device;
d) repeating steps a)-c) for a third time period having a duration in a range of 5 to 500 ms in order to generate a first train of pulses wherein each pulse consists of the impulse of the time-varying magnetic field and the second time period;
e) switching the switching device off after the third time period for a fourth time period having a duration in a range of 10 to 1200 ms and generating no magnetic field;
f) repeating steps a)-e) at least once during a fifth time period having a duration in a range of 3 to 120 seconds;
g) repeating steps a) and b) and switching the switching device off for a sixth time period at least nine times longer than the first time period and different from the second time period;
h) repeating step g) for a seventh time period having a duration in a range of 1.5 to 6 seconds in order to generate a second train of pulses of the time-varying magnetic field wherein the second train of pulses differs from the first train of pulses and wherein the seventh time period consists of first, second, and third subperiods each having a duration in a range of 0.5 to 2 seconds;
wherein an amplitude of a magnetic flux density of each subsequent magnetic pulse of the second train of pulses increases to a predetermined magnetic flux density value during the first subperiod;
wherein the amplitude of the magnetic flux density of each subsequent magnetic pulse of the second train of pulses maintains the predetermined magnetic flux density value during the second subperiod; and
wherein the amplitude of the magnetic flux density of each subsequent pulse of the second train of pulses decreases during the third subperiod from the predetermined magnetic flux density value;
i) switching the switching device off after the seventh time period for an eighth time period having a duration in a range of 1 to 5 seconds and generating no magnetic field by the magnetic field generating device; and
j) repeating steps g)-i) at least once during a ninth time period having a duration of at least 30 seconds.

US Pat. No. 10,245,437

SYSTEM AND METHOD FOR PROVIDING NONINVASIVE VENTILATION

INOVYTEC MEDICAL SOLUTION...

1. A system configured to assist minimally trained persons to operate it to provide treatment in emergency situations involving respiratory failure and/or cardiac arrhythmias, said system comprising:A) an Airway and Ventilation device (AV) comprising:
i) a face mask;
ii) at least one sensor adapted to monitor vital signs (VS);
iii) a pressurized oxygen source configured to provide a flow of oxygen via said face mask and an airway to a patient and to adjust the oxygen flow on the basis of said monitored vital signs;
B) an Automated External Defibrillator (AED) device comprising one or more electrocardiogram (ECG) detectors that are adapted to be attached to the chest of said patient and are configured to both monitor ECG and to apply electrical shock to said patient via one or more chest pads;
C) a user interface for providing audible or visual instructions to an operator;
D) components that provide communication functionality;
E) a data management unit adapted to operate said system, to provide instructions to the operator, and to record ECG and VS data said data management unit comprising:
i) a processor;
ii) dedicated software; and
iii) memory units;characterized in that the face mask comprises:a) a face attachment unit configured to be attached and secured to the face of a patient by means of connectors that ensure a tight fitting of the face attachment unit to the face contours;
b) a mask body configured to be releasably connected to said face attachment unit by a quick release/attachment mechanism;
wherein said face mask body comprises:
i) a hollow tube that passes from the interior side to the exterior side of said face mask body and is configured to provide a mouth airway securing channel;
ii) a CO2 sensor configured to measure end tidal CO2 (ETCO2) in exhalations of said patient; and
iii) a ventilation tube connected to a portable ventilator configured to deliver air or oxygen to said patient and to remove exhaled air from said patient; and
wherein said quick release/attachment mechanism is configured to allow quick removal of said mask body from said face attachment unit, leaving only the face attachment unit attached by the connectors to the patients' face and leaving the mouth and nose of the patient exposed to the surroundings; and
additionally characterized in that the processor and dedicated software are configured to determine when to apply electric shock according to evaluation of the state of ventilation, wherein the state of ventilation is evaluated according to the ETCO2 measured in each chest compression applied by the operator to the patient.

US Pat. No. 10,245,435

WIRELESS NEURAL STIMULATOR IMPLANTATION

Stimwave Technologies Inc...

1. A method for implanting a neurostimulator system, comprising:inserting an introducer sheath and a needle, carried by the introducer sheath, through an incision site on a patient and into an epidural space of the patient;
withdrawing the needle through the introducer sheath and out of the patient;
after withdrawing the needle out of the patient, inserting the neurostimulator system through the introducer sheath and into the epidural space of the patient, the neurostimulator system comprising an enclosure housing electrodes and at least one passive antenna, the at least one passive antenna configured to receive, via electric radiative coupling, electrical energy and waveform parameters from an antenna located exteriorly to the patient, and the electrodes configured to generate electrical waveforms from the electrical energy and the waveform parameters received at the at least one passive antenna;
advancing the neurostimulator system through the epidural space until the electrodes are positioned adjacent a targeted tissue of the patient so that the electrodes can apply the electrical waveforms to render pain relief therapy to the targeted tissue and in a manner such that a proximal portion of the enclosure remains external to the patient;
removing the introducer sheath from the epidural space of the patient;
removing the proximal portion of the enclosure from the neurostimulator system to leave an implanted portion of the enclosure remaining in the epidural space such that the implanted portion of the enclosure has a customized length that is specific to the patient;
after removing the proximal portion of the enclosure, attaching a cap carrying a radiopaque marker to the implanted portion of the enclosure; and
after attaching the cap to implanted portion of the enclosure, further attaching the cap to a connective tissue at the incision site to anchor the implanted portion of the enclosure to the patient.

US Pat. No. 10,245,433

SELECTIVE HIGH FREQUENCY SPINAL CORD MODULATION FOR INHIBITING PAIN WITH REDUCED SIDE EFFECTS, AND ASSOCIATED SYSTEMS AND METHODS

Nevro Corp., Redwood Cit...

1. A spinal cord modulation system, comprising:an implantable signal generator having a machine-readable medium containing instructions that, when executed, generate a therapy signal having a frequency between 1.5 kHz and 10 kHz, an amplitude between 0.5 mA and 4 mA, and pulse widths between 30 microseconds and 35 microseconds; and
an implantable signal delivery device coupleable to the implantable signal generator and designed to be implanted within a patient's epidural space to deliver the therapy signal from the implantable signal generator to the patient's spinal cord.

US Pat. No. 10,245,432

METHOD AND APPARATUS FOR TREATMENT OF FOCAL DYSTONIA

MED-EL Elektromedizinisch...

1. A method of treating focal dystonia comprising:a. providing a system comprising a stimulating electrode operably connected with a processor configured to set one or more stimulation parameters for an electrical impulse deliverable by said electrode;
b. placing said electrode in communication with at least one muscle;
c. using said processor to set said stimulation parameters such that said electrical impulse is adapted to cause a level of stimulation which does not exceed an excitability threshold of one or more alpha motor neurons located within said at least one muscle; and
d. delivering said electrical impulse to said at least one muscle.

US Pat. No. 10,245,431

REAL-TIME SEIZURE PREDICTION INFORMED BY HIDDEN MARKOV MODEL EVENT STATES

The Trustees of the Unive...

1. An implantable medical device for predicting and treating electrical disturbances in tissue, the medical device including:an implantable telemetry unit (ITU) including a processor and an electrode circuit; and
an implantable leads assembly (ILA) including a first electrode and a second electrode implantable in the tissue and electrically coupled to the electrode circuit of the ITU,
wherein the processor of the ITU is configured to perform training by:
receiving electrical signals input to the electrode circuit by the first and second electrodes,
parsing the electrical signals into dynamic event states using Bayesian Non-Parametric Markov Switching, and
modeling each event state as a multi-dimensional probability distribution,
wherein the processor of the ITU is further configured to perform analysis of the electrical signals and therapy to the tissue by:
receiving other electrical signals input to the electrode circuit by the first and second electrodes,
applying the other electrical signals to the multi-dimensional distribution to predict future electrical disturbances in the tissue, and
controlling the electrode circuit to apply an electrical therapy signal to the first and second electrodes to mitigate effects of the future electrical disturbances in the tissue.

US Pat. No. 10,245,430

SIGNAL PROCESSING METHOD FOR COCHLEAR IMPLANT

iMEDI PLUS Inc., Zhubei ...

1. A signal processing method for a cochlear implant, the cochlear implant comprising a microphone and a speech processor, the signal processing method being executed by the speech processor comprising:receiving an electrical speech signal from the microphone;
segmenting the electrical speech signal to a plurality of time-sequenced noisy frames;
reducing noise in each of the plurality of time-sequenced signal frames to obtain a plurality of clean signal frames, the plurality of clean signal frames comprising a (t-1)-th clean frame xt-1 and a t-th clean frame xt;
obtaining a (t-1)-th compression factor ?t-1 according to the (t-1)-th clean frame xt-1;
obtaining a t-th compression factor ?t for the t-th clean frame xt according to the compression factor ?t-1 and the t-th clean frame xt;
obtaining a t-th output frame zt based on the t-th compression factor ?t; and
outputting the t-th output frame zt.

US Pat. No. 10,245,429

METHODS AND APPARATUS FOR RENAL NEUROMODULATION

Medtronic Ardian Luxembou...

1. A method for catheter-based renal denervation of a hypertensive human patient, the method comprising:intravascularly positioning a distal region of a catheter within a renal artery associated with a kidney of the patient; and
at least partially ablating target neural tissue innervating the kidney of the patient via ultrasound energy from the catheter, wherein the ultrasound energy is delivered via an ultrasound transducer carried by a shaft of the catheter,
wherein at least partially ablating the target neural tissue results in a therapeutically beneficial reduction in blood pressure of the patient.

US Pat. No. 10,245,427

IMPLANTABLE LEAD WITH FLEXIBLE PADDLE ELECTRODE ARRAY

Advanced Neuromodulation ...

1. A neurostimulation lead comprising:a lead body having a proximal end and a distal end
a plurality of conductive terminals being disposed at the proximal end of the lead body;
a flexible paddle being disposed at the distal end of the lead body, the flexible paddle comprising:
a row of laterally aligned flexible electrodes, the row of laterally aligned flexible electrodes at least partially contributing to the formation of a flex line in the flexible paddle; and
a row of laterally aligned nonflexible electrodes longitudinally offset from the row of laterally aligned flexible electrodes such the flex line does not extend across the row of laterally aligned nonflexible electrodes.

US Pat. No. 10,245,426

MEDICAL PATCH

Seoul National University...

1. A medical patch having an electric potential generating structure which is attachable to a wound to thus regenerate injured skin tissues, the medical patch having a piezoelectric potential generating structure comprising a plurality of unit patches stacked one on another, each of the plurality of unit patches comprising a first layer, a second layer and a plurality of piezoelectric nanorods disposed between the first and second layers,wherein when the medial patch is attached to a skin for use, the piezoelectric potential generating structure converts mechanical energy originating from a movement of muscle into a piezoelectric potential,
wherein the plurality of piezoelectric nanorods comprise a plurality of biaxially-grown piezoelectric nanorods, which are aligned horizontally along with in-plane direction of the first layer or the second layer,
wherein the plurality of biaxially-grown piezoelectric nanorods have an average length ranging from 2.5 ?m to 3 ?m and an average diameter ranging from 200 nm to 250 nm, and are symmetrically bent based on middle portion of the nanorods by the muscle movement of the skin to which the patch is attached,
wherein when mechanical load is applied to the biaxially-grown piezoelectric nanorods by the muscle movement of the skin, a first half of each of the biaxially-grown piezoelectric nanorods exhibits positively polarized piezoelectric potentials and a second half opposed to the first half of each of the biaxially-grown piezoelectric nanorods exhibits negatively polarized piezoelectric potentials,
wherein the first and second layers are flexible such that the medical patch is attachable to the skin for use.

US Pat. No. 10,245,425

ELECTRIC DEVICE FOR MEASURING EEG SIGNAL OR ELECTRIC STIMULATION

YBRAIN INC., Seoul (KR)

1. An electric device for measuring an Electroencephalogram (EEG) signal from a subject's head and for providing electric stimulation to the subject's head, the electric device comprising:a plurality of electrode units configured to be attached to each different position of the head of the subject, and configured to
detect the EEG signal from the subject's head, and
supply electric current to the each different position, each of the plurality of electrode units including a plurality of microelectrodes forming an electric array;
an electric stimulation unit configured to supply electric current in order to provide the electric stimulation to the subject's head;
a switching unit connected to the electric stimulation unit and the plurality of electrode units, and configured to switch
the each of the plurality of electrode units to be selectively connected and
each of the plurality of microelectrodes to be selectively connected; and
a controller connected to the switching unit, and configured to
control the switching unit to be selectively connected to each of the plurality of the electrode units to receive the EEG signal from the subject's head through connected electrode unit among the plurality of electrode units, and
control the switching unit to selectively supply, through the switching unit and the connected electrode unit, the electric current from the electric stimulation unit to the subject's head,
wherein the controller is configured to control the switching unit to supply the electric current from the electric stimulation unit to the subject's head through the each of the plurality of the microelectrodes, and
wherein the controller is configured to
receive a first plurality of EEG signals detected from a first plurality of microelectrodes included in first electrode unit among the plurality of electrode units,
select at least one microelectrode, which is configured to simultaneously receive the EEG signal from the subject's head and supply the electric current to the subject's head, from the first plurality of microelectrodes based on the received first plurality of EEG signals,
receive a first EEG signal from the subject's head through the selected at least one microelectrode among the first plurality of microelectrodes, and
control, at the same time as receiving the first EEG signal, the switching unit to supply the electric current to the subject's head through the selected at least one microelectrode.

US Pat. No. 10,245,424

UV STERILIZING CATHETERS AND CATHETER CONNECTORS

1. A catheter connector system releasably connecting a supply port of an intravenous line to a patient connector of an catheter, comprising:a connector body having:
(a) an inner wall defining an interior of the connector body, said inner wall being transmissive to ultraviolet (UV) light; and
(b) an outer wall defining an exterior of the connector body;
one or a plurality of UV light sources disposed between the inner wall and the outer wall or on the outer wall and positioned to emit UV light into the interior of the connector body;
a flow sensor for sensing a flow of fluid in the interior of the catheter;
circuitry for electrically connecting the UV light sources, the flow sensor and a power source, such that electrical power is supplied to the UV light sources when fluid flow is sensed through the interior of the catheter;
wherein the supply port and the inner wall of the connector body are both at least partially transmissive to UV light;
wherein the flow sensor comprises electrodes which extend into the interior of the connector body, wherein electrical power is supplied to the UV light sources when the fluid in the interior of the connector body has a conductivity sufficient to conduct electricity between said electrodes; and
a UV light reflector disposed between the outer wall and inner wall of the connector body or on the outer wall of the connector body and positioned to reflect UV light into the interior of the connector body and said connected supply port.

US Pat. No. 10,245,423

METHOD FOR MANUFACTURING MICROSTRUCTURE USING CENTRIFUGAL FORCE AND MICROSTRUCTURE MANUFACTURED BY SAME

JUVIC INC., Seoul (US)

1. A method for manufacturing a microstructure, the method comprising:applying a viscous material onto a surface of a substrate; and
rotating the substrate about an axis such that the surface faces away from the axis while rotating, which causes the viscous material to extend generally in a direction perpendicular to the surface and away from the axis by centrifugal force applied to the viscous material, thereby providing a microstructure comprising at least one microneedle elongated from and attached to the surface,
wherein the method adjusts at least one dimension of the microstructure which is selected from the group consisting of a length, a diameter, and an aspect ratio by adjusting the centrifugal force.

US Pat. No. 10,245,419

POSITIONABLE VALVULOPLASTY CATHETER

InterValve Medical, Inc.,...

1. A method of operating a balloon catheter comprising:A. advancing a balloon catheter to a valve, said balloon catheter having a balloon disposed at a distal end of an elongated shaft, said balloon having a distal bulb, a proximal bulb, and a waist located between said distal bulb and said proximal bulb, said balloon extending through an annulus of the valve from a first side to an opposite second side of the annulus,
B. said distal bulb being formed from a noncompliant material, said proximal bulb being formed from a material more compliant than said noncompliant material of said distal bulb,
C. inflating said balloon to a first pressure ranging from zero to 0.5 atmospheres to inflate said distal bulb to a fully inflated distal bulb diameter, said proximal bulb having a maximum diameter smaller than said fully inflated distal bulb diameter at the first pressure,
D. positioning said balloon with the waist being positioned in the annulus of the valve and the distal bulb being adjacent to the annulus of the valve at the second side,
E. further inflating said balloon to a second pressure that is larger than said first pressure thereby expanding said proximal bulb to a fully inflated proximal bulb diameter, said proximal bulb expanding against leaflets of the valve,
F. said fully inflated proximal bulb diameter and said fully inflated distal bulb diameter being larger than a waist diameter.

US Pat. No. 10,245,418

APPARATUS FOR A MEDICAL SYSTEM INFLATION SYRINGE

Semler Technologies, Inc....

1. A medical system inflation syringe that enables fluid communication selective interconnectability to other medical systems or devices, by means of removable attachment to a female Luer connector that complies to the ISO 594 standard, said syringe comprising at least a plunger and a barrel, a distal end of said barrel further including a barrel lumen and a nozzle, at least one shroud tab, at least one standoff rib, at least one vent, and a nozzle base, wherein:The nozzle further includes at least an insertion outside diameter, a lumen, and a distal opening at the nozzle's distal-most end, the lumen of the nozzle in open communication with the barrel lumen;
The at least one shroud tab is placed circumferentially around and at a distance from the nozzle and enables a friction fit between the interior wall of the at least one shroud tab and an exterior wall of the female Luer connector;
The at least one standoff rib is placed so that it extends radially from the nozzle and nozzle base to the interior wall of the at least one shroud tab;
The at least one vent is placed at the same distance from the nozzle as the at least one shroud tab and has the same height from the distal end of the barrel as said shroud tab;
The at least one vent enables a backflow of air that escapes from the connected female Luer connector that is not a swabable valve, when air is injected from the syringe into said connected female Luer connector against a resistance on the interior side of said female Luer connector;
The insertion outside diameter is located on the nozzle where the distal-most portion of the standoff rib connects to the nozzle and is less than the minimum inside diameter of any female Luer connector compliant to ISO 594 standard;
The at least one standoff rib has a height, measured from the distal end of the barrel so that when said standoff rib: i) comes into contact with the rim of the female Luer connector that is not part of a swabable valve, and the nozzle is inserted into said female Luer connector, an airtight connection between said connector and the distal opening of the nozzle is precluded, and, ii) comes into contact with the rim of the female Luer connector that is part of a swabable valve, and the nozzle is inserted into said female Luer connector, an airtight connection between said connector and the distal opening of the nozzle is established.

US Pat. No. 10,245,417

PACKAGE FOR EXTENDED SHELF LIFE OF LIQUID CORE CATHETERS

RA MEDICAL SYSTEMS, INC.,...

1. A package assembly to extend a shelf life of a liquid core catheter, comprising:a liquid core catheter comprising a core liquid;
a polymer spiral tube which includes an inner lumen filled with a storage liquid that is soluble in or miscible with the core liquid of the liquid core catheter and which is sealed at both ends to contain the storage liquid in the inner lumen of the polymer spiral tube; and
a sealed pouch which is made of either metallized plastic or polychlorotrifluoroethylene that acts as a hermetic seal for liquids disposed within the sealed pouch and which includes a hermetically sealed inner volume with the polymer spiral tube and liquid core catheter being disposed within the hermetically sealed inner volume.

US Pat. No. 10,245,416

INTRAVENOUS CATHETER DEVICE WITH INTEGRATED EXTENSION TUBE

Becton, Dickinson and Com...

1. An assembled intravenous catheter device, comprising:a catheter adapter having a proximal end, a distal end, and a lumen interposed therebetween, the catheter adapter further comprising a securement platform, the distal end comprising an intravenous catheter and the proximal end comprising an extension tube and an access port extending outwardly from the extension tube, wherein the intravenous catheter, the access port, and the extension tube are in fluid communication with the lumen;
a needle hub having a closed end, an open end, and a compartment interposed therebetween, the closed end being configured to receive a terminal end of the extension tube and the open end configured to receive the proximal end of the catheter adapter, wherein the extension tube is stored within the compartment, the needle hub having an access slot extending through the open end, wherein the access port extends through the access slot and is slidable in a distal direction within the access slot; and
an introducer needle having a base end, a tip end and a body extending therebetween, the base end being securely attached to the closed end of the needle hub, and the body extending through the proximal end, the lumen, the distal end, and the intravenous catheter such that the tip end of the introducer needle is exposed beyond a terminal end of the intravenous catheter.

US Pat. No. 10,245,415

MEDICAL ARTICLE WITH ROTATABLE WINGS

Venetec International, In...

1. A medical device assembly, comprising:a catheter, including a catheter hub;
a housing surrounding the catheter hub, the housing spaced from the catheter hub such that a channel is defined therebetween;
a first wing having a first hook disposed in the channel to permit rotation of the first wing about the catheter hub, the first wing extending from the catheter hub in a first direction; and
a second wing having a second hook disposed in the channel to permit rotation of the second wing about the catheter hub, the second wing extending from the catheter hub in a second direction opposite the first direction.

US Pat. No. 10,245,414

MEDICAL DEVICE WITH SELECTIVE RIGIDITY

Cook Medical Technologies...

1. An expandable and compressible medical device for obtaining selective rigidity with respect to a patient, comprising:an elongate flexible catheter that extends between a distal end portion and a proximal end portion with a first lumen disposed through the catheter, and a second lumen that extends through a catheter wall into the distal end portion, wherein the distal end portion of the catheter wall is an expandable portion;
the catheter wall comprises a first layer that defines an inner surface of the first lumen and a second layer disposed radially outside of the first layer, and wherein the first and second layers are sealed together proximate to a distal tip of the catheter, and an interface is established between the first and second layers, wherein the interface is established within a volume bounded by the first layer, the second layer, and locations where the first and second layers are sealed together, the interface is located within the expandable portion of the catheter wall; and
further comprising a retention member disposed within the interface between the first and second layers within the distal end portion, and wherein the second lumen is fluidly connected with the interface,
wherein the retention member is configured to be aligned in a dense configuration under an influence of a vacuum force applied to the interface via the second lumen, wherein the retention member is biased to expand to a less dense configuration when the interface is at atmospheric pressure,
wherein at least a portion of a surface of one or both of the first and second layers that establish the interface is a sticky portion, and the sticky portion is configured to releasably stick to other portions of the interface under the influence of the vacuum force.

US Pat. No. 10,245,411

MEDICAL ELONGATED BODY

TERUMO KABUSHIKI KAISHA, ...

1. A medical elongated body comprising:a tubular main body comprising a lumen, the tubular main body extending in an axial direction, the tubular main body possessing an outer surface, a distal portion and a proximal portion;
a hub connected to the proximal portion of the tubular main body, the hub comprising an interior that communicates with the lumen of the tubular main body, the hub possessing a distal portion; and
a strain relief supported by the distal portion of the hub and surrounding a predetermined range of the proximal portion of the tubular main body;
a hydrophilic lubricating coating layer on the outer surface of the tubular main body, the hydrophilic lubricating coating layer exhibiting lubricating characteristics when wet;
a temperature responsive lubricating coating layer on the outer surface of the tubular main body, the temperature responsive lubricating coating layer exhibiting hydrophilic characteristics and lubricating characteristics at a temperature lower than a critical temperature when wet and exhibiting hydrophobic characteristics and non-lubricating characteristics at a temperature equal to or higher than the critical temperature when wet; and
the temperature responsive lubricating coating layer being proximal to the hydrophilic lubricating coating layer on the outer surface of the tubular main body.

US Pat. No. 10,245,408

METHOD, APPARATUS AND COMPUTER PROGRAM PRODUCT FOR PROVIDING A DYNAMIC WAKE-UP ALERT

NOKIA TECHNOLOGIES OY, E...

1. A method comprising:determining, with a processor, a sleep recovery need of a user, wherein the sleep recovery need of the user comprises at least one needed sleep quality component and at least one needed sleep duration component, the at least one needed sleep duration component corresponding to a respective one of the at least one needed sleep quality component;
receiving a desired sleep recovery from a user input, the desired sleep recovery being a ratio of the determined sleep recovery need that the user desires to achieve;
adjusting the determined sleep recovery need of the user based on the desired sleep recovery;
in response to a sleep event indication indicative of a sleep event, monitoring with the processor, sleep data relating to the user to calculate a real-time gained recovery indicative of gained sleep qualities and gained sleep durations, each gained sleep durations corresponding to a respective one of the gained sleep qualities, wherein the sleep event indication is generated based on at least a sensor;
comparing the real-time gained recovery to the at least one needed sleep quality component and the at least one needed sleep duration component indicated by the adjusted sleep recovery need of the user to determine that the real-time gained recovery satisfies the adjusted sleep recovery need of the user; and
in response to determining that the real-time gained recovery satisfies the adjusted sleep recovery need of the user, causing a wake-up alert to be provided via a user interface of a device.

US Pat. No. 10,245,407

CONNECTIONS FOR HUMIDIFICATION SYSTEM

14. A cartridge for use with a respiratory humidifier, the cartridge comprising:a housing comprising an upper laterally extending surface, at least one securing member extending upwardly beyond the upper laterally extending surface of the housing,
the housing comprising a rear surface extending downward from the upper laterally extending surface; and
a first rearwardly protruding element extending rearwardly beyond an immediately adjacent portion of the housing and a second rearwardly protruding element extending rearwardly beyond an immediately adjacent portion of the housing, the first rearwardly protruding element and the second rearwardly protruding element being generally vertically aligned, the first rearward protruding element and the second rearwardly protruding element being positioned vertically lower than the upper laterally extending surface,
the first rearwardly protruding element comprising a first deflectable portion and the second rearwardly protruding element comprising a second deflectable portion such that the first deflectable portion and the second deflectable portion are deflectable laterally inward toward each other.

US Pat. No. 10,245,405

FACE MASK

RIC INVESTMENTS, LLC, Wi...

1. A mask assembly configured to provide gas to a patient, comprising:a mask body having an opening for reception of the gas, the mask body including a seal structure configured to sealingly engage with the face of the patient and surround at least the nose and mouth of the patient, the mask body having a connecting portion; and
an elbow-shaped conduit releasably connected with the connecting portion of the mask body and being configured to deliver the gas to the patient through the opening, the conduit comprising a first connector portion which connects with the connecting portion, and a second connector portion constructed and arranged to connect with a circuit tubing, wherein the first connector portion comprises a plurality of recesses at an interface with the connecting portion to allow exhaled gas to escape therethrough, the conduit being separate and distinct from the mask body and configured to be separate and distinct from the circuit tubing.

US Pat. No. 10,245,404

PATIENT INTERFACE SYSTEMS

ResMed Limited, Bella Vi...

1. A patient interface system for delivering a flow of breathable gas to a patient, comprising:a patient interface support structure configured to be connected to a hose that delivers the flow of breathable gas;
a pair of nasal pillows supported by the patient interface support structure, wherein each nasal pillow is configured to seal against an interior of the patient's nares;
a support member configured to engage a bridge of the patient's nose; and
a connecting member configured to connect the support member and the patient interface support structure,
wherein said pair of nasal pillows is selectively repositionable in a plurality of positions relative to the support member while remaining engaged with the patient's nares.

US Pat. No. 10,245,403

BREATHING MASK ARRANGEMENT AS WELL AS AN APPLICATION DEVICE AND A FOREHEAD SUPPORT DEVICE FOR SAME

1. A respiratory mask assembly for providing respiratory therapy to a patient, the respiratory mask assembly comprising:a frame including a main body and a forehead support extending from the main body, the forehead support including a pair of upper headgear holding members, and the frame further including a conduit carrier portion having an insert opening;
a pair of lower headgear holding members configured to be provided to the main body of the frame;
a mask releasably coupled with the frame, the mask including a body portion and a sealing portion, and
the mask forming a mask internal space pressurizable to a therapeutic pressure above ambient pressure,
wherein the body portion includes a circular inlet opening structured to receive a flow of air at the therapeutic pressure for breathing by the patient,
wherein the body portion includes an inside surface exposed to said therapeutic pressure in use and an outside surface exposed to ambient pressure, and the main body of the frame includes a wall arranged along the outside surface of the body portion so that the wall is outside the mask internal space,
wherein the body portion includes a plurality of outlet openings for discharge of gas from the mask internal space to ambient atmosphere,
wherein the frame includes an opening configured and arranged to expose the plurality of outlet openings when the mask and the frame are coupled to one another,
the sealing portion is constructed and arranged to form a seal with a patient's nose and mouth, the sealing portion including a hole therein adapted to receive the patient's nose and mouth such that the flow of air at the therapeutic pressure is delivered to the patient's nose and mouth,
wherein the sealing portion comprises an elastomer material and the body portion does not comprise an elastomer material;
a positioning and retaining arrangement structured and arranged to releasably couple the mask to the frame,
the positioning and retaining arrangement comprising a mask retainer part provided to the body portion of the mask and a frame retainer part provided to the frame,
wherein the main body, the conduit carrier portion, and the frame retainer part of the frame comprise a one-piece structure,
wherein the frame retainer part is structured and arranged to engage the mask retainer part to releasably retain the mask to the frame;
a respiratory gas conduit member structured to connect to a respiratory gas conduit to deliver the flow of air at the therapeutic pressure to the mask internal space, and the respiratory gas conduit member is mounted within the insert opening of the conduit carrier portion of the frame; and
headgear to maintain the respiratory mask assembly in position on a patient's head, the headgear including upper bands adapted to connect to the upper headgear holding members of the frame and lower bands adapted to connect to the lower headgear holding members, and the upper bands adapted to be routed over respective ones of a patient's ears and the lower bands adapted to be routed under respective ones of the patient's ears.

US Pat. No. 10,245,402

ENDOBRONCHIAL TUBE WITH INTEGRATED IMAGE SENSOR

1. An endobronchial tube comprising:a first lumen having an open distal end;
a first inflatable cuff;
a second lumen having an open distal end;
a second inflatable cuff distal to the open distal end of the first lumen;
a dedicated image sensor lumen located at least partially within a wall of said endobronchial tube, the dedicated image sensor lumen comprising a distal end;
an image sensor and an illumination source, disposed in the dedicated image sensor lumen adjacent the open distal end of said first lumen;
at least one dedicated cleaning lumen disposed within said wall of said endobronchial tube, the at least one dedicated cleaning lumen having a distal end,
wherein said at least one dedicated cleaning lumen curves at the distal end of the dedicated cleaning lumen to form a cleaning nozzle having an opening in an external surface of the dedicated image sensor lumen distal to the image sensor, and
wherein the dedicated image sensor lumen comprises a tubular surface within the wall of the endobronchial tube and a partially annular surface extending from the tubular surface, the partially annular surface forming the external surface of the endobronchial tube on which the opening of the cleaning nozzle is located.

US Pat. No. 10,245,401

SUBGLOTTIC SUCTIONING SYSTEM

Avent, Inc., Alpharetta,...

1. A tracheal tube for a subglottic suctioning system, the tracheal tube comprising:a flexible cannula having a length, a distal end, and a proximal end, the cannula comprising a plurality of separate lumens including a respiratory lumen, a suction lumen and an inflation lumen;
an inflatable cuff surrounding the cannula above the distal end and adapted to seal the trachea of a patient and further having the inflation lumen in fluid communication with the inflatable cuff; and
a port extending through a side wall of the cannula proximal to the inflatable cuff, the port in fluid communication with the suction lumen; and
a valve body located proximal to the cannula, the valve body having
a first valve on the suction lumen on a proximal end of the body having a failsafe open position and a second position that requires positive action by a user to close the suction lumen, and
a check valve that operates independently of the first valve and through which rinsing fluid will flow from a bullet or syringe into the suction lumen distal to the first valve when the bullet or syringe is squeezed by a user,
wherein the first valve returns to the failsafe open position when the positive action by the user stops and the check valve closes and stops the flow of rinsing fluid when the user stops squeezing the bullet or syringe.

US Pat. No. 10,245,399

AUTOMATED INSPIRATORY MUSCLE TRAINING FOR PATIENTS RECEIVING MECHANICAL VENTILATION

UNIVERSITY OF FLORIDA RES...

1. A system for automated inspiratory muscle strength training of a patient during mechanical ventilation comprising:a gas delivery device, wherein said gas delivery device comprises an inhalation assembly that provides breathing gas for inspiratory air flow during patient spontaneous inhalation and includes a valve that controls the breathing gas during a pre-determined number of the spontaneous inhalations;
a control module configured to instruct the gas delivery device to control the breathing gas to maintain a pressure adapted to be below a baseline pressure of a mechanical ventilator during the pre-determined number of spontaneous inhalations; and
a sensing assembly, operably connected to the control module, wherein the sensing assembly, through the operable connection to the control module, is configured to monitor the pressure and facilitate control of the gas delivery device to provide breathing gas for inspiratory air flow.

US Pat. No. 10,245,398

RESPIRATORY HUMIDIFIER AND LIGHTING DEVICE FOR RESPIRATORY HUMIDIFIER

Hamilton Medical AG, (CH...

1. A respiratory humidifier with a lighting device to facilitate observation of the fill level of water in a liquid container from which humidity is added to the breathing gas, the humidifier including a housing with a heating plate and the liquid container with a bottom plate which, when brought into contact with the heating plate, heats the liquid in the liquid container, wherein:the housing includes a projecting portion having a downwardly-facing wall surface with a light-exit portion, the housing containing an electrical light source directed toward the light-exit portion such that light from the electrical light source exits downwardly therefrom;
the liquid container includes an upwardly-facing light-entrance portion directly adjacent to and facing the light-exit portion and positioned above the water therein such that light proceeds from the light source through the light-exit portion and light-entrance portion downwardly into the liquid container to illuminate the surface of the water, and at least certain parts of the container surfaces of the liquid container being transparent.

US Pat. No. 10,245,397

DEVICE AND METHOD FOR PERFORMING RESPIRATORY TRAINING

Rheinisch-Westfaelische-T...

1. An apparatus for respiratory training, the apparatus comprising:a mouthpiece through which a person is able to exhale and inhale respiratory gas;
a variable-volume container forming at least part of a closed space connected to the mouthpiece;
at least one gas-permeable membrane delimiting a part of the closed space on one side and forming on an opposite side a gas-exchange chamber; and
means operated by the respiratory gas flow of the inhaled and exhaled respiratory gas for flowing an O2 or CO2 gas-exchange fluid over the opposite side of the membrane.

US Pat. No. 10,245,395

METERING SYSTEM AND METHOD FOR AEROSOL DELIVERY

DEKA Products Limited Par...

1. An apparatus for determining the volume of a fluid, the apparatus comprising:a printed circuit board wherein the printed circuit board separates a first volume and a second volume including a gas region and a fluid region, the printed circuit board comprising:
an acoustic source;
a first microphone disposed within the first volume; and
a second microphone disposed within the second volume; and
a processor configured to calculate a change in volume of the gas region wherein the processor determines an amount of fluid output from the fluid region.

US Pat. No. 10,245,393

METHODS, SYSTEMS, AND DEVICES RELATED TO A SUPPLEMENTAL INHALER

Elwha LLC, Bellevue, WA ...

1. A system comprising:circuitry configured to assess one or more parameters associated with flow through at least one flow channel disposed within an inhaler used by a subject to obtain at least one assessed flow value;
circuitry configured to calculate an amount of propellant that will increase flow through the at least one flow channel to meet or exceed a threshold flow value if the at least one assessed flow value is below the threshold flow value including at least circuitry configured to compare the at least one assessed flow value to a particular threshold flow value related to the subject; and
circuitry configured to dispense at least one agent with the amount of propellant that will cause the flow through the at least one flow channel to meet or exceed the particular threshold flow value.

US Pat. No. 10,245,392

OXYGEN CONCENTRATING DEVICE, WOUND CARE APPARATUS, AND TREATMENT METHODS

NEOGENIX, LLC, Fort Laud...

1. A wound care device comprising:an oxygen port for supplying oxygen gas for wound care;
an oxygen concentrating device fluidly connected to the oxygen port, the oxygen concentrating device including:
a first membrane electrode assembly (MEA) for the production of oxygen gas from air, which comprises:
a first electrode fluidly connected to a source of ambient air;
a cover disposed between the first electrode and the source of ambient air, the cover including at least one passage which fluidly connects the first electrode to the source of ambient air such that the cover restricts moisture loss from the first electrode,
a second electrode spaced from the first electrode, the second electrode being fluidly connected to a first basin such that the first basin is fluidly connected to the oxygen port, and
a first ion conducting membrane positioned between the first and second electrodes, which comprises:
a first conductive wire connected to the first electrode, and
a second conductive wire connected to the second electrode, such that the application of a substantially constant flow of electrical current through the first conductive wire and the second conductive wire electrochemically produces oxygen on the second electrode from ambient air adjacent the first electrode, and such that when the source of ambient air has an ambient relative humidity which is equal to or less than 30%, the voltage across the first electrode and the second electrode increases less than 25% after 15 days of electrochemically producing oxygen on the second electrode as the result of the application of the substantially constant flow of electrical current;
wherein the at least one passage has a radius that is equal to or greater than 0.159 mm.

US Pat. No. 10,245,391

FLUID RESERVOIR FOR AN AEROSOL GENERATION DEVICE, COMBINATION OF FLUID RESERVOIR AND PRIMARY FLUID PACKAGE, AND AEROSOL GENERATION DEVICE FOR USE WITH THE FLUID RESERVOIR

PARI Pharma GmbH, Starnb...

1. A fluid reservoir which is attachable to an aerosol generation device for guiding a fluid to the aerosol generation device, the fluid reservoir comprising:a fluid container; and
an interface portion affixed to the fluid container and configured to attach the fluid container to the aerosol generation device, wherein
the interface portion includes a locking element configured to lock the fluid container to the aerosol generation device after attachment of the fluid container to the aerosol generation device, and
the interface portion includes a weakened portion that is breakable to enable detachment of the fluid container from the aerosol generation device.

US Pat. No. 10,245,390

ADHESIVE AND PERIPHERAL SYSTEMS AND METHODS FOR MEDICAL DEVICES

DEKA Products Limited Par...

1. A needle injector device for connection in fluid-flow communication with the inlet or outlet port of a reservoir, the needle injector comprising:a housing;
a hollow needle supported in the housing for movement relative to the housing between a start position, an extended position and a retracted position, the needle having a piercing end having an opening and an opposite, second end having an opening;
a fluid conduit connected to the opening on the second end of the hollow needle and moveable with the hollow needle;
a first bias member supported by the housing and arranged to impart a first bias force in a first direction on the attached needle from the start position to the extended position of the needle;
a second bias member arranged to impart a second bias force in a second direction, opposite to the first direction, for moving the attached needle from the extended position to the retracted position;
wherein at least a portion of the first bias member is located outside the housing, and wherein at least a portion of the second bias member is located outside the housing.

US Pat. No. 10,245,389

ADHESIVE AND PERIPHERAL SYSTEMS AND METHODS FOR MEDICAL DEVICES

DEKA Products Limited Par...

1. A delivery device for delivering an infusion medium to a user, the device comprising:a disposable housing assembly adapted to be secured to a user's skin;
a reservoir having an interior for containing a fluidic medium, the reservoir having an outlet port and being operatively coupled to a pumping assembly to selectively drive fluid out the outlet port from the reservoir interior;
a base portion comprising the reservoir, the base portion having a reservoir cavity, and a fluid path, the reservoir cavity comprising the outlet port and a septum, the fluid path comprising a fluid channel from the outlet port to a cannula port;
at least one flexible membrane portion attached onto the base portion and forming a top of the reservoir cavity and a top of the fluid channel; and
a tubing connected to the base portion at the cannula port, the tubing in fluid communication with the reservoir cavity; and
a needle insertion device for inserting a cannula into the user's skin, the needle insertion device comprising an introduction needle for movement between a retracted position and an extended position;
wherein the disposable housing assembly has a passage through which the introduction needle extends, and
wherein the cannula has a central passage through which the introduction needle extends.

US Pat. No. 10,245,388

INJECTION DEVICE FOR MINIMALLY INVASIVE PROCEDURES AND USES THEREOF

Global Bio Therapeutics, ...

1. An injection device, comprising:a) a syringe barrel, wherein the syringe barrel provides a fluid reservoir;
b) a plunger configured to be controlled by the operator of the device and to move within the syringe barrel for loading and releasing fluid from the fluid reservoir in the syringe barrel;
c) an injection needle that is fixed and operably coupled to the syringe barrel providing a fluid pathway for fluid contained in the syringe barrel to be injected into a target tissue when the plunger is depressed, wherein extraction or retraction of the needle is independent of movement of the plunger;
d) an elongate sheath, comprising an internal lumen that contains the injection needle and having a distal tip that contains an opening for the injection needle, wherein:
the sheath is movable around the injection needle; and
control of the sheath is independent from movement of the plunger; and
e) a controller for positioning the sheath, comprising:
a housing, comprising at least a first and second stop to control exposure of the injection needle and that are provided within the housing at a predetermined distance from each other, wherein the stops can be locked;
a central lumen in the housing comprising a connection member, wherein the connection member is configured to be movable in the central lumen in the housing and is coupled to the sheath, wherein the proximal end of the sheath is coupled to the distal end of the connection member so that movement of the connection member controls movement of the sheath; and
a positioner mounted within the housing configured to move forward towards the distal end of the controller and rearward towards the proximal end of the controller, between the stops in the housing, wherein the positioner comprises a lock and release element that is configured in the positioner to engage the positioner with the stops, and is operatively connected to the connection member to guide movement of the connection member in the same direction, whereby movement of the positioner forward towards the distal end engages the first stop and moves the sheath to enclose the injection needle inside the lumen of the sheath, and movement of the positioner rearward towards the proximal end engages the second stop and moves the sheath to expose no more than a predetermined length of the distal tip of the injection needle through the opening for the injection needle for injection into the tissue.

US Pat. No. 10,245,387

MEDICAMENT DELIVERY DEVICE

SHL MEDICAL AG, Zug (CH)...

1. A multi-dose medicament delivery device comprising:a device front end;
a device back end;
a central longitudinal axis;
a housing having a housing front end and a housing back end;
a medicament container assembly, the medicament container assembly being configured for accommodating a medicament container with a stopper;
a dose drum that is supported in the housing via a first threaded connection;
wherein the dose drum is axially movable with respect to the housing in a backward direction from an initial position to at least one dosing position when rotated in a first direction in order to set a dose to be delivered; and
wherein the dose drum is axially movable with respect to the housing in a forward direction from the dosing position to the initial position when rotated in a second, opposite direction in order to deliver the dose set;
a plunger rod that is operationally associated with the stopper and supported in the housing via a second threaded connection, wherein the threaded connection is configured to axially guide the plunger rod toward the device front end when the plunger rod is rotated in the second direction, where the plunger rod has an inner surface with an inwardly radial protruding tooth corresponding to a predetermined dosing position; and
an activation assembly comprising:
a plunger rod rotator that is coupled to the dose drum and has at least one first deflecting member comprising an outwardly radial protruding tooth;
an activator rod that is axially movable with respect to the plunger rod rotator from an uncoupling position to a coupling position, wherein, when the activator rod is in the coupling position and the dose drum is rotated in the second direction from the dosing position the plunger rod does not rotate until the outwardly radial protruding tooth of the at least one first deflecting member engages the inwardly radial protrusion; and
at least one second deflecting member that is configured to lock the activator rod with respect to the plunger rod rotator in the coupling position until the dose drum reaches the initial position again.

US Pat. No. 10,245,386

FORCE AMPLIFIER

Niswey, L.L.C., Atlantic...

1. A linear force amplifier, comprising:a housing having a length;
a force multiplier having an input screw substantially non-rotating relative to said housing and having an axis, to which an input force to be amplified is applied relative to said housing, an output screw substantially non-rotating relative to said input screw, providing a resulting output force relative to said housing, and a rotating nut rotatable about said input screw axis and disposed to receive and engage each of said input screw and said output screw and disposed to engage said housing and provide a force to said housing opposite to said resulting output force, wherein said output screw is movable in a first direction when said input force is applied and is retractable opposite said first direction upon relief of said input force;
an advancement ratchet disposed to engage said output screw and receive said output force relative to said housing having an output member providing an increasing ratchet output member displacement in said first direction in response to a plurality of cycles of force multiplier output screw motion in said first direction advancement and retraction therefrom.

US Pat. No. 10,245,384

SENSOR FOR USE WITH A DRUG DELIVERY DEVICE

Sanofi-Aventis Deutschlan...

1. An optical decoding system comprising:a single optical sensor integral with or attachable to a housing of a drug delivery device and configured to be directed at first and second rotatable components of a dose setting and dispensing mechanism of the drug delivery device; and
a processor configured to:
cause the single optical sensor to capture one or more images of the first and second rotatable components at least at a beginning and an end of a medicament dose dispensing process;
determine a rotational position of both the first and second rotatable components in each of the captured images; and
determine from the rotational positions of the first and second rotatable components an amount of medicament delivered by a dose setting and a dispensing mechanism of the drug delivery device.

US Pat. No. 10,245,381

TWO-STEP AUTO-INJECTION DEVICE

Chalbourne Brasington, G...

1. An auto-injection device defining a longitudinal direction, the auto-injection device comprising:an ampoule, the ampoule comprising a fluid medicament contained between a first stopper located towards a proximal end of the ampoule and a second stopper located towards a distal end of the ampoule, wherein the first stopper includes a first recess located at a proximal edge of the first stopper and a second recess located at a distal edge of the first stopper, wherein the second recess is disposed between the first recess and the second stopper;
a first sleeve movable along the longitudinal direction relative to the ampoule;
a second sleeve at least partially surrounding the ampoule and movable along the longitudinal direction relative to the ampoule, wherein the second sleeve is movable from a proximal end of the auto-injection device towards a distal end of the auto-injection device; and
a needle located at the proximal end of the auto-injection device;
wherein the first sleeve is movable along the longitudinal direction relative to the second sleeve and the ampoule between a first position and a second position, wherein in the first position the needle is unexposed along the longitudinal direction and in the second position the needle is exposed along the longitudinal direction, further wherein a proximal end of the first sleeve is in direct contact with a proximal end of the second sleeve in the second position, and
wherein the second sleeve is movable along the longitudinal direction relative to the ampoule between a first position and a second position, wherein in the first position the needle is fluidly isolated from the fluid medicament and in the second position the needle is in fluid communication with the fluid medicament.

US Pat. No. 10,245,380

CONTAINER CLOSURE, CONTAINER ASSEMBLY AND METHOD FOR UTILIZING THE SAME

William Beaumont Hospital...

1. A portion of a container assembly comprising:a container closure including an end wall connected to a side wall, wherein the end wall includes a central portion and an outer perimeter portion, wherein the side wall includes a proximal end and a distal end, wherein the proximal end of the side wall is connected to and extends away from the outer perimeter portion of the end wall, wherein the end wall includes an inner surface and an outer surface, wherein the side wall includes an inner surface and an outer surface; and
a needle sheath member that extends axially away from and is integral with the inner surface of the end wall of the container closure, wherein the needle sheath member forms a needle-receiving passage that is sized for receiving a needle extending from a needle hub that is removably-attached to a syringe, wherein the needle-receiving passage is in fluid communication with a needle hub-engaging portion that is defined by the outer surface of the end wall of the container closure, and wherein the needle hub-engaging portion is sized for receiving the needle hub that is removably-attached to a syringe;
wherein the outer surface of the end wall of the container closure defines a syringe-engaging portion, and
wherein the container closure includes a fluid-drawing member that extends axially away from and is integral with the inner surface of the end wall of the container closure, wherein the fluid-drawing member includes a proximal end and a distal end, wherein a fluid-flow passage extends through the fluid-drawing member between the proximal end of the fluid-drawing member and the distal end of the fluid-drawing member, and wherein the proximal end of the fluid-drawing member is connected to and extends away from the inner surface of the end wall of the container closure.

US Pat. No. 10,245,379

CANNULATED DOSE DELIVERY DEVICE, SYSTEM AND METHOD OF USE

Med Dose Solutions, LLC, ...

1. An apparatus comprising:a plunger housed in a barrel, wherein the plunger comprises;
a plunger proximal end connector configured to receive a washing agent;
a plunger end cap configured to facilitate the washing of a delivery chamber of the barrel;
an elongated cylinder having an internal chamber defining a fluid pathway between the plunger proximal end connector and the plunger end cap; wherein the plunger end cap comprises a plurality of slits in the distal end of the plunger end cap, wherein the slits are spaced apart.

US Pat. No. 10,245,377

DRUG DELIVERY SYSTEMS WITH SEALED AND STERILE FLUID PATHS AND METHODS OF PROVIDING THE SAME

INSULET CORPORATION, Act...

1. A system, comprising:a container having a main body and a neck, the container configured to hold a liquid drug;
a cap coupled to the neck, the cap configured to seal an open end of the container;
a fluid path having a first end disposed within the cap and a second end disposed within a cover;
an energy source configured to emit energy; and
a shield positioned adjacent to the container, the shield configured to expose the fluid path to the emitted energy while blocking exposure of the liquid drug to a substantial portion of the emitted energy.

US Pat. No. 10,245,376

ASSEMBLY INCLUDING A NEEDLE FOR ADMINISTERING A FLUID

Sanofi, Paris (FR)

1. An assembly comprising:a needle for administering a fluid, the needle comprising:
a hollow needle body configured to guide the fluid, the needle body being formed such that an inlet section of the needle body defines a first flow direction for the fluid, and an outlet section of the needle body defines a second flow direction for the fluid, wherein the first flow direction is inclined with respect to the second flow direction, and wherein the needle body comprises a bend which connects the inlet section and the outlet section;
a needle unit comprising the needle, the needle being fixed to a needle hub, wherein the needle unit further comprises a needle housing which covers a part of the bend of the needle body,
a reservoir retaining fluid, wherein the needle is fluidly connected to the reservoir, and
an assembly housing, wherein the needle unit is rotatably mounted to the assembly housing such that the needle hub is axially secured but rotatable with respect to the assembly housing, the needle unit being rotatable relative to the assembly housing such that a longitudinal axis of the outlet section of the needle body points toward a dose member.

US Pat. No. 10,245,373

PUMP CASSETTES WITH POSITIONING FEATURE AND INFUSION PUMP SYSTEMS

CareFusion 2200, Inc., S...

1. A pump cassette comprising:a rigid body comprising a frame portion, a base portion, a compliant membrane disposed substantially therebetween, two opposing edge sections, and an interface-facing surface;
a controllable fluid pathway defined at least in part by the base portion and the compliant membrane;
a first positioning feature on the frame portion and arranged substantially orthogonal to a general plane of the interface-facing surface, the first positioning feature configured to mechanically interact with a first corresponding positioning feature on a surface of a cassette recess of an infusion pump for positioning of the pump cassette within the cassette recess;
a second positioning feature on the frame portion, laterally separated from the first positioning feature, arranged substantially orthogonal to the general plane of the interface-facing surface, and configured to mechanically interact with a second corresponding positioning feature on the surface of the cassette recess of the infusion pump for positioning of the pump cassette within the cassette recess, wherein the second positioning feature comprises a protrusion on the frame portion within which a portion of the controllable fluid pathway is disposed; and
a slider coupled to the two opposing edge sections and longitudinally articulable with respect to the rigid body.

US Pat. No. 10,245,371

ANASTOMOTIC DEVICE AND METHODS

1. A stent graft comprising:a sidewall port device configured for coupling the stent graft to an aperture in a tissue wall; and
a conduit configured to extend through the aperture in the tissue wall for transporting fluid when implanted, the side wall port device comprising a lattice inverted onto itself to form an inner tube disposed coaxially within an outer tube.

US Pat. No. 10,245,369

SYSTEMS AND METHODS FOR PRIMING HEMODIALYSIS USING DIALYSIS FLUID

Baxter International Inc....

1. A method for priming a hemodialysis treatment comprising:providing a disposable cassette including at least a portion of a dialysate circuit and at least a portion of a blood circuit;
placing a dialyzer in fluid communication with the dialysate circuit via a to-dialyzer dialysate line and a from-dialyzer dialysate line;
placing the dialyzer in fluid communication with the blood circuit via an arterial blood line and a venous blood line;
placing a source of dialysis fluid in fluid communication with the dialyzer;
priming the dialysate circuit with dialysis fluid from the source while both the to-dialyzer dialysate line and the from-dialyzer dialysate line are connected at their dialyzer ends to the dialyzer; and
priming the blood circuit with dialysis fluid from the source by actuating at least one valve provided by the disposable cassette.

US Pat. No. 10,245,368

INTEGRATED HYBRID BIO-ARTIFICIAL LIVER BIOREACTOR DESIGN AND METHOD THEREOF

INDIAN INSTITUTE OF TECHN...

1. A hybrid Bioartificial liver bioreactor comprising:at least three chambers adapted to be positioned as ax integrated and a single unit including:
a top chamber, provided with a first inlet/outlet port, comprising a plasma separation membrane configured to separate a blood stream received from a patient into plasma and blood cells;
a middle chamber, provided with a second inlet/outlet port to connect with the top or a bottom chamber, said middle chamber seeded with hepatocyte cells in a semi-interpenetrating supermacroporous cryogel;
the bottom chamber provided with a third inlet/outlet port to connect with the top or middle chambers, the bottom chamber configured for plasma collection and reintroduction of said plasma or part thereof to one of said top or middle chambers;
where said top and middle chambers are configured to be separated in position by a means for filtering, toxic compounds, and
where said middle and bottom chambers are separated by a means for trapping cellular material from leaking out of said bioreactor.

US Pat. No. 10,245,367

AMBULATORY LUNG ASSIST DEVICE WITH IMPLANTED BLOOD PUMP AND OXYGENATOR

HeartWare, Inc., Miami L...

1. A portable lung assist system, comprising:an implantable blood pump having a pump outlet and a pump inlet configured for communication with a circulatory system of a patient at an inlet location; and
an external and portable blood oxygenator having a blood inlet releasably connectable to the pump outlet and a blood outlet releasably connectable to the circulatory system of the patient at a return location; and
a bypass conduit connectable to the blood pump, wherein the oxygenator and the bypass conduit are in continuous fluid communication with the blood pump when the blood inlet is connected to the pump outlet.

US Pat. No. 10,245,366

IMPLANTABLE HEART TREATMENT SYSTEMS, DEVICES, AND METHODS

Elwha LLC, Bellevue, WA ...

1. A method of treating a heart with an implanted heart treatment device, comprising:generating, via a heart treatment device implanted within a body of a biological subject, one or more electric signals configured to stimulate one or more tissues of a heart within the body during a fibrillation event of the heart;
administering the one or more electric signals to the one or more tissues of the heart; and
delivering, via the heart treatment device, one or more non-oxygen cellular energy sources to one or more tissues of the heart, after the fibrillation event has proceeded for a duration sufficient to exhaust the myoglobin-based oxygen of the heart.

US Pat. No. 10,245,365

REPLENISIHING UREASE IN DIALYSIS SYSTEMS USING A UREASE INTRODUCER

Medtronic, Inc., Minneap...

1. A method, comprising the steps of:detecting an amount of urea directly or indirectly by measuring products proportional to an amount of urea in a sample in a dialysate downstream of a sorbent cartridge; wherein the sorbent cartridge contains urease and at least one or more other sorbent materials; and
supplying urease to the sorbent cartridge by a urease introducer if the amount of urea downstream of the sorbent cartridge is above a threshold, wherein the sorbent cartridge is adapted to receive an adjustable amount of urease, wherein the urease introducer comprises any one of a slideable tray and a door.

US Pat. No. 10,245,364

SAFETY APPARATUS FOR EXTRACORPOREAL BLOOD TREATMENT

Fresenius Medical Care De...

1. A blood purification device comprising:an extracorporeal blood circuit with a blood inflow to a dialysis unit for blood removed from a patient and a blood outflow from the dialysis unit for blood being guided back into the patient, wherein the dialysis unit comprises an inflow for a dialysis solution and a dialysate outflow,
a citrate anticoagulation apparatus, wherein citrate is supplied to the extracorporeal blood circuit at a citrate supply point upstream of the dialysis unit and a substitute medium dosing apparatus, wherein substitution medium is supplied at a substitution medium supply point downstream of the dialysis unit,
a control loop for controlling the acid-base balance of the blood, wherein bicarbonate is supplied to the blood by means of an aqueous bicarbonate-containing solution, wherein at least one measuring means for measuring a blood buffer parameter is associated with the control loop and upstream of the citrate supply point in the extracorporeal blood circuit, wherein the blood buffer parameter is selected from the group consisting of bicarbonate concentration and CO2 partial pressure, and wherein a signal corresponding to the measured actual value of the blood buffer parameter can be supplied to a control apparatus, which regulates the actual value of the blood buffer parameter via the supply of bicarbonate to a predeterminable intended value or intended value range,
at least one pH-measuring means, which is arranged upstream of the citrate supply point in the extracorporeal blood circuit, wherein a signal corresponding to the pH value can be supplied to an alarm apparatus, which triggers an alarm signal if a predeterminable pH value or a pH-value range is exceeded or undershot,
wherein the arrangement of the at least one measuring means for measuring a blood buffer parameter located upstream of the citrate supply point in the extracorporeal blood circuit and the at least one pH-measuring arranged upstream of the citrate supply point are configured to detect and prevent or treat disturbances of the acid-base balance during an extracorporeal blood purification selected from the group of compensated acidosis, non-compensated acidosis, compensated alkalosis and compensated or non-compensated alkalosis,
at least one additional measuring means for measuring a blood buffer parameter that is associated with the control loop and arranged downstream of the dialysis unit and upstream of the substitution medium supply point in the extracorporeal blood circuit, and
at least one additional pH-measuring means that is arranged downstream of the substitution medium supply point in the extracorporeal blood circuit, wherein a signal corresponding to the pH value can be supplied to the alarm apparatus, which triggers an alarm signal if a predeterminable pH value or pH-value range is exceeded or undershot.

US Pat. No. 10,245,363

CATHETER-BASED PUMP FOR IMPROVING ORGAN FUNCTION

Stanton J. Rowe, Newport...

1. A method for improving renal function of a patient, comprising:mechanically occluding an inferior vena cava downstream of a renal vein ostium to form an upstream region and a downstream region of the inferior vena cava; and
mechanically pumping blood through the inferior vena cava from the upstream region to a discharge location in the downstream region while the inferior vena cava is occluded, wherein the blood remains in the inferior vena cava while being mechanically pumped.

US Pat. No. 10,245,362

BLOOD PUMP FOR TREATMENT OF BRADYCARDIA

HeartWare, Inc., Miami L...

1. A ventricular assist device comprising:a rotary pump configured to be implantable in fluid communication with a ventricle and an artery of a subject to assist blood flow from the ventricle to the artery;
a pump drive circuit for applying power to the pump;
a pump drive circuit to control the speed of the pump;
one or more sensors for sensing one or more electrogram signals in a patient;
a signal processing circuit in communication with the sensors and the pump drive circuit, the signal processing circuit being configured to receive the electrogram signals and:
determine an impending onset or absence of a bradycardia arrhythmia based on the electrogram signals from the sensors;
during the impeding onset of a bradycardia arrhythmia, determine the impending onset of sinus bradycardia or heart block;
control power supplied to the pump from the pump drive circuit so as to control the speed of the pump and:
operate the pump in a normal sinus rhythm mode in the absence of an arrhythmia;
operate the pump in a first modified mode of operation during the impending onset of heart block or sinus bradycardia.

US Pat. No. 10,245,360

CONNECTOR RING CLAMP AND ASSOCIATED METHODS OF USE

HeartWare, Inc., Miami L...

1. A connector ring assembly comprising:an annular wall defining a first opening adapted to receive a conduit, the first opening having an opening axis;
a clamp having a body and a first arm and a second arm coupled to each other by the body, the first arm and the second arm defining a distance therebetween extending away from body and entirely along the first arm and the second arm, the clamp engaging the annular wall and defining a second opening co-axial with the first opening, the clamp operably configured to rotate relative to the annular wall in a first state and remain fixed relative to the annular wall in a second state, and the distance between the first arm and second arm in the first state being greater than the distance between the first arm and second arm in the second state;
an actuator disposed substantially parallel with respect to the annular wall and the clamp, the actuator adapted to transition the clamp between the first state and the second state; and
an actuator receiver defining an actuator opening including the actuator disposed therein, the actuator opening having an actuator axis generally parallel to the opening axis.

US Pat. No. 10,245,358

EVAPORATIVE BODY-FLUID CONTAINERS AND METHODS

KCI Licensing, Inc., San...

1. A system for treating a tissue site with reduced pressure, the system comprising:a manifold configured to be placed proximate to the tissue site;
a sealing member configured to cover the manifold and the tissue site to form a sealed space;
a reduced-pressure source configured to be fluidly coupled to the sealed space; and
a container for receiving body fluids from the tissue site, the container comprising:
at least one wall having a plurality of apertures,
a liquid-impermeable, vapor-permeable material defining a portion of an interior space of the container, wherein the liquid-impermeable, vapor-permeable material is coupled to the at least one wall and covers the plurality of apertures,
a fluid inlet fluidly coupled to the interior space and configured to be fluidly coupled to the sealed space,
a fluid outlet fluidly coupled to the interior space and configured to be fluidly coupled to the reduced-pressure source, wherein the fluid outlet is separate from the plurality of apertures, and
a filter disposed in the fluid outlet;
wherein the liquid-impermeable, vapor-permeable material is adapted to come into contact with the body fluids received in the container and is adapted to retain the body fluids received in the container.

US Pat. No. 10,245,357

SYSTEM AND KIT FOR THE COLLECTION AND PROCESSING OF AMNIOTIC FLUID AND PLACENTAL ASPIRATE

PENSARA, INC, Richmond, ...

6. A kit for collection, separation and reuse of cellular material from amniotic fluid and placental aspirate comprising:a canister having a coil, wherein the coil is hollow and has a tear drop shaped cross-section, and a cellular accumulation chamber, said cellular accumulation chamber having a port, said canister having an inlet and an outlet, said coil connected to said inlet and to said outlet, said canister suitable for attachment to a vacuum line;
a syringe having a needle suitable for insertion into said port of said cellular accumulation chamber; and
a dual-chambered applicator suitable for receiving cellular material from said syringe.

US Pat. No. 10,245,353

HYDROPHILIC ELECTROSPINNING BIOLOGICAL COMPOSITE STENT MATERIAL USED FOR TISSUE REGENERATION AND PREPARATION METHOD AND APPLICATION THEREOF

1. A hydrophilic electrospinning biological composite scaffold material, wherein it is prepared by blending an aqueous solution of fibrinogen and L-arginine or hydrochloride thereof with a P(LLA-CL) solution using an electrospinning technique, wherein the hydrophilic electrospinning biological composite scaffold material has an equilibrium contact angle, and the equilibrium contact angle thereof is less than 55°.

US Pat. No. 10,245,352

CATHETER SHAFT HAVING HIGH STRENGTH AND FLEXIBILITY

ABBOTT CARDIOVASCULAR SYS...

1. An elongated shaft for a catheter, comprising a single layer biaxially oriented nonporous thermoplastic polymer tubular member having a Shore durometer hardness of less than about 75D.

US Pat. No. 10,245,344

DEODORIZING CATCH TRAY FOR HAND DRYERS

1. A device for catching water drippings below a hand dryer, comprising:a catch tray adapted to mount to a wall, the catch tray defining a recess in a top surface thereof, the catch tray including a base tray and a back wall, wherein a first recess portion is disposed in a top surface of the base tray and a second recess portion, continuous with the first recess portion, is disposed in an angled front face of the back wall;
a deodorizing screen removably disposed in the recess, the deodorizing screen comprising a first screen portion disposed in the first recess portion and a second screen portion, at an angle to the first screen portion and continuous therewith, disposed in the second recess portion; and
a sponge disposed in the recess below the first screen portion;
wherein the catch tray does not include a cover such that the deodorizing screen is at all times exposed and visible from above the catch tray.

US Pat. No. 10,245,343

SCENTED WAFER

1. A scented wafer for emitting a scent to a surrounding open environment,said scented wafer being uncovered to present a large surface area for emission of scent to the surrounding open environment, and comprising a body material formed of a heat-resistant fibrous material having a predetermined porosity resulting from a selected denier and length of fibers; and
a scented material impregnated into the body material and constructed to melt and release a scent when exposed to heat of a predetermined temperature that exceeds the temperature of the surrounding open environment and a melting point of the scented material;
wherein the body material retains structural integrity and does not melt at the predetermined temperature to facilitate the reuse or replacement of the wafer, and
the body is formed with numerous edges and grooves to create a large surface area for emission of the scented material when heated and melted.

US Pat. No. 10,245,340

ROOM AND AREA DISINFECTION UTILIZING PULSED LIGHT WITH MODULATED POWER FLUX AND LIGHT SYSTEMS WITH VISIBLE LIGHT COMPENSATION BETWEEN PULSES

Xenex Disinfection Servic...

1. A disinfection apparatus, comprising:a germicidal pulsed light source arranged within the disinfection apparatus such that germicidal light generated from the germicidal pulsed light source is projected exterior to the disinfection apparatus;
trigger voltage circuitry for applying a trigger voltage to the germicidal pulsed light source at a set frequency greater than approximately 20 Hz;
power supply circuitry;
one or more electrical charge storage devices coupled to the power supply circuitry and to the germicidal pulsed light source;
pulse duration circuitry coupled between the one or more electrical charge storage devices and the germicidal pulsed light source, wherein the one or more electrical charge storage devices and the pulse duration circuitry are configured to discharge a set amount of stored energy in a set amount of time such that energy flux of ultraviolet light in the wavelength range between 200 nm and 320 nm generated at the germicidal pulsed light source is between approximately 20 J/m2 and approximately 1000 J/m2;
an occupancy sensor for determining presence of an individual in a region extending at least 1.0 meter from the disinfection apparatus;
a processor; and
program instructions executable by the processor for inhibiting and terminating the generation of light from the germicidal pulsed light source upon the occupancy sensor detecting presence of an individual.

US Pat. No. 10,245,339

APPARATUS AND METHOD OF STERILIZING LUMENS IN MEDICAL INSTRUMENTS

19. A method of sterilizing an internal surface of a lumen in a medical instrument comprising:a) providing an apparatus including an elongated UVC light guide having a central longitudinal axis, a distal end portion and a proximal end portion, said distal end portion including a reflective attachment comprising a sleeve or tube and at least one reflective surface, said sleeve or tube being secured to said distal end portion of said UVC light guide and being formed of a material through which UVC light can readily pass, said at least one reflective surface being located within said sleeve or tube and extending at an angle to said central longitudinal axis and being configured for directing UVC light radially outward from said central longitudinal axis through said sleeve or tube;
b) coupling a source of UVC light to said proximal end portion of said elongated UVC light guide, said source of UVC light including at least one LED for producing UVC light when said at least one LED is energized;
c) inserting said UVC light guide within said lumen of said instrument;
d) energizing said source of UVC light to produce UVC light, whereupon said UVC light guide carries said UVC light from said source of UVC light internally down said UVC light guide to said reflective attachment from whence said UVC light is directed radially outward through said sleeve or tube to impinge said internal surface of said lumen to sterilize that surface; and
e) moving said UVC light guide through said lumen while said source of UVC light is producing said UVC light to thereby sterilize the length of said internal surface of said lumen.

US Pat. No. 10,245,337

MULTIFUNCTION LIGHT-EMITTING DIODE LIGHTING APPARATUS

SEOUL VIOSYS CO., LTD., ...

1. A multifunction Light-Emitting Diode (LED) lighting apparatus installed on a product, including:a module including a substrate having a first surface and a second surface opposite to the first surface;
at least one lighting LED disposed on the first surface of the substrate;
at least one ultraviolet (UV) LED disposed on the first surface of the substrate; and
a cover disposed to face the substrate at a specific interval from the substrate and configured to cover the at least one lighting LED and the at least one UV LED,
wherein the at least one lighting LED and the at least one UV LED are integrally disposed over the substrate to form the module,
wherein the module is disposed on the product such that the second surface of the substrate is installed on an inside wall of the product,
wherein the module is configured to radiate ultraviolet rays to a fluid in an interior of the product and provide illumination to the interior of the product, and
wherein the cover includes a first region facing the at least one lighting LED and a second region facing the at least one UV LED,
wherein the cover further includes a light diffusion unit formed in the first region and configured to diffuse light emitted from the lighting LED,
wherein the cover further includes an opening unit formed in the second region such that UV rays radiated from the light UV LED are directed to the product and the cover further includes a material covering the opening unit and having a property to allow the UV rays to pass through the material, and
wherein the cover further includes a partition that partitions the first region and the second region.

US Pat. No. 10,245,336

SYSTEM FOR HANDLING STERILISATION OF THIN-BODY FLEXIBLE CONTAINERS (POUCH)

Guala Pack S.P.A., (IT)

1. Method of sterilisation of flexible pouches, comprising the steps of:producing a plurality of pouches, wherein each pouch comprises a container body formed by walls made of flexible film and a spout comprising an entrance portion with an inlet and a tube with an outlet, said spout being sealingly applied to the container body so as to protrude outside of it with at least a section of the tube;
providing a plurality of sacrificial closures reversibly applicable to the outlet mouth of the spout;
applying, sealingly and reversibly, the sacrificial closure to the outlet of the spout, thereby obtaining provisionally closed non-filled pouches to be sterilised;
loading a plurality of provisionally closed non-filled pouches to be sterilised on a transport device for collective transport;
forming a transport group, containing a plurality of transport devices, each carrying the provisionally closed non-filled pouches to be sterilised, stacked;
transporting the transport group from the site of the producer subject to a steriliser subject;
performing a sterlisation of the entire transport group loaded with provisionally closed non-filled pouches, by ionising radiation;
picking the sterilised provisionally closed non-filled pouches from the transport device and sending them in succession to a sterile chamber;
for each sterilised provisionally closed non-filled pouch, making at least a portion of the tube provided with the sacrificial closure to pass through the sterile chamber;
during said passing through of the sterile chamber, separating the sacrificial closure from the tube, filling the sterilised open pouch and applying a tamper-proof cap to the tube to close the pouch.

US Pat. No. 10,245,335

STERILIZING METHOD AND APPARATUS

Turbett Surgical LLC, Ro...

1. A sterilizing cabinet assembly, comprising:(a) a cabinet having an access port;
(b) a door connected to the cabinet, the door moveable between an open position permitting passage through the access port to an interior of the cabinet and a closed position precluding passage through the access port;
(c) at least one of the cabinet and the door having a vent port;
(d) a primary filter overlying the vent port and forming a sealed interface with an adjacent portion of the one of the cabinet and the door;
(e) a secondary filter overlying at least a portion of the primary filter; and
(f) a filter holder moveable between an open position and a closed position and configured to hold the primary and secondary filters, the filter holder having a first filter holder section overlying the primary filter and a second filter holder section overlying the secondary filter, wherein the secondary filter is separable from the filter holder and the primary filter when the second filter holder section is in the open position, while maintaining the sealed interface between the primary filter and the adjacent portion of the one of the cabinet and the door.

US Pat. No. 10,245,334

REFRACTION TECHNOLOGY SYSTEM

Richard J. Barrett, Roth...

1. A method for modifying the monoatomic oxygen level in a fluid, comprising:(a) providing a first electrode defining a first conductive surface spaced from a second electrode defining a second conductive surface;
(b) providing a porous divider positioned intermediate the first electrode and second electrode and defining a first fluid treatment chamber with the first conductive surface and a second fluid treatment chamber with the second conductive surface;
(c) providing a positive charge to the first electrode and a negative charge to the second electrode;
(d) flowing an initial fluid having an initial oxidation reduction potential (ORP) value from an inlet to the first chamber and the second chamber via an end cap defining a first fluid inlet to the first chamber and a second fluid inlet to the second chamber, wherein the first fluid inlet is configured to allow a greater volume of fluid per unit time to the first chamber than the second fluid inlet allows to the second chamber, thereby modifying the monoatomic oxygen level of the initial fluid in both chambers; and
(e) collecting positive oxygen fluid having a positive ORP value greater than the initial ORP value from the first chamber and negative oxygen fluid having a negative ORP value lower than the initial ORP value from the second chamber.

US Pat. No. 10,245,333

PLASMA GENERATING APPARATUS AND TREATMENT METHOD USING THE SAME

ELECTRONICS AND TELECOMMU...

1. A plasma generating apparatus comprising:a housing configured to provide an inner space in which plasma is generated;
a ground electrode coupled to one side of the housing;
a power electrode coupled to the other side of the housing; and
a controller configured to control a generation mode of the plasma,
wherein the generation mode comprises:
a first mode in which the plasma is provided to a target to be processed while generating the plasma; and
a second mode in which the plasma is generated in the housing, and then the generated plasma is provided to the target to be processed.

US Pat. No. 10,245,329

COMPOSITION HAVING DYE AND CONJUGATE OF POLYETHYLENEGLYCOL AND ADDITIVE AND CONTRAST AGENT FOR PHOTOACOUSTIC IMAGING HAVING THE SAME

CANON KABUSHIKI KAISHA, ...

1. A contrast agent suitable for photoacoustic imaging, comprising: a compound represented by formula (1), (5), (6), or (7); and an additive, which interacts with the compound, wherein the additive is at least one selected from the group consisting of an ?-cyclodextrin, a ?-cyclodextrin, a hydroxypropyl-?-cyclodextrin, and a ?-cyclodextrin:
wherein R301 to R312 are each independently selected from the group consisting of a hydrogen atom, a halogen atom, —PO3T301, a substituted or unsubstituted phenyl group, thiophene group, or pyridinyl group and a linear or branched alkyl group having 1 to 18 carbon atoms;
T301 is selected from the group consisting of a hydrogen atom, a sodium atom and a potassium atom;
R31 to R34 are each independently selected from the group consisting of a hydrogen atom and a linear or branched alkyl group having 1 to 18 carbon atoms;
A31, B31 and B32 each independently represent a linear or branched alkylene group having 1 to 18 carbon atoms;
L31 to L37 are each independently selected from the group consisting of CH and CR35 and may form a 4- to 6-membered ring;
R35 is selected from the group consisting of a linear or branched alkyl group having 1 to 18 carbon atoms, a halogen atom, a substituted or unsubstituted phenyl group, pyridinyl group, or benzyl group, ST302 and a linear or branched alkylene group having 1 to 18 carbon atoms;
T302 is selected from the group consisting of a linear or branched alkyl group having 1 to 18 carbon atoms, a substituted or unsubstituted phenyl group and a linear or branched alkylene group having 1 to 18 carbon atoms;
Q31 is selected from the group consisting of —CONT31-, —NT31CO—, —NT31(C?O) NT31-, —NT31(C?S) NT31-, —NT31(C?O)O—, —O—, —S—, —S(?O)2NT31-, —OP(?O)(OT31)O—, —S—S—, —CT31=N—, —CT31=N—NH—, —CT31=N—O—, —CT31=N—NH—O—, —CONT31-R37—(C?O)O—, —CONT31-R37—CONT31-, formula (2) and formula (3);
T31 is selected from the group consisting of a hydrogen atom and an alkyl group having 1 to 5 carbon atoms;
R37 is selected from the group consisting of —CH(CO2T37)-, —CH(CH2CO2T37)- and a linear or branched alkylene group having 1 to 18 carbon atoms;
T37 is selected from the group consisting of a hydrogen atom, a sodium atom, a potassium atom and an alkyl group having 1 to 5 carbon atoms;
R38 is selected from the group consisting of an alkyl group having 1 to 18 carbon atoms, a hydrogen atom, —OCH3, —NH2, —OH, —CO2T38, —S(?O)2OT38, —P(?O)(OT38)2 and —OP(?O)(OT38)2;
T38 is selected from the group consisting of a hydrogen atom, a sodium atom and a potassium atom;
R39 is selected from the group consisting of a hydrogen atom, —OCH3, —NH2, —OH, —S(?O)2OT39, —CO2T39, —P(?O)(OT39)2, —CONH—CH(CO2T39)-CH2(C?O)OT39, —CONH—CH(CO2T39)-CH2CH2(C?O)OT39 and —OP(?O)(OT39)2;
T39 is selected from the group consisting of a hydrogen atom, a sodium atom and a potassium atom;
q is an integer from 1 to 20;
n is an integer from 2 to 250:

US Pat. No. 10,245,326

AMANTADINE, MEMANTINE, AND RIMANTADINE CONJUGATES AND A PHARMACEUTICAL COMPOSITION FOR TREATMENT OF NEURONAL DISORDERS

1. A method of treating Parkinson's disease, the method comprising:administration to subject having Parkinson's disease, a therapeutically effective amount of an amantadine analog conjugate compound having the formula (II):
where R1 in each occurrence is independently H, or C1-C4 alkyl; R2 is a nullity or CH—CH3, R3 is a nullity or C(O)—R6—NH; R6 is C2-C6 alkyl, (CH2CH2—O)n, or (CH(OH)CH2)n; n is an integer of between 1 and 4; R4 is a nullity or NH—R6—C(O); and R5 is a moiety capable of crossing the blood brain barrier and is as a free compound is one of: serotonin, dopamine, blood brain barrier (BBB) peptide, membrane translocating peptide, TAT peptides, endocannabinoids, bradykinin, beta-endorphin, bombesin, calcitonin, cholecystokinin, an enkephalin, dynorphin, insulin, gastrin, substance P, neurotensin, glucagon, secretin, somatostatin, motilin, vasopressin, oxytocin, prolactin, thyrotropin, an angiotensin, galanin, neuropeptide Y, thyrotropin-releasing hormone, gonadotropnin-releasing hormone, growth hormone-releasing hormone, luteinizing hormone, vasoactive intestinal peptide transferrin, glucosyl ester, lactic acid, leucine, tryptophan, glutamic acid.

US Pat. No. 10,245,325

METHODS AND COMPOSITIONS FOR THE SUSTAINED RELEASE OF CHROMIUM

JDS Therapeutics, LLC, P...

1. A composition comprising:a chromium complex comprising:
an amount of a fast-acting chromium complex; and
an amount of a slow-acting chromium complex; wherein the fast-acting chromium complex is absorbed more quickly by an individual to whom it is administered than the slow-acting chromium complex;
wherein the amount of a fast acting chromium complex and the amount of the slow-reacting chromium complex are formulated to have a molar ratio of chromium between 1:10 and 10:1.

US Pat. No. 10,245,323

DRUG DEVICE CONFIGURED FOR WIRELESS COMMUNICATION

Pop Test Abuse Deterrent ...

1. A method for treatment of withdrawal from narcotics and subsequent prevention of relapse of narcotic use in a patient in need of such treatment, said method comprising:(a) forming an ingestible drug delivery device by a device manufacturer, said ingestible drug delivery device comprising:
a capsule body comprising:
a bioactive substance module comprising a container for holding a volume and/or quantity of bioactive substance therein and a microactuator for dispensing said bioactive substance from said container to a location outside of said capsule body, wherein said bioactive substance is a composition comprising:
i) a first therapeutic agent which is a GCR antagonist, or pharmaceutically acceptable salts thereof;
ii) separated from the first therapeutic agent, at least one additional therapeutic agent(s) selected from the group consisting of opioid analgesics and combinations thereof; and
iii) at least one pharmaceutically acceptable carrier, wherein the first therapeutic agent and said at least one additional therapeutic agent(s) are each present in an amount which, in combination, is a therapeutically effective amount for treatment of withdrawal from narcotics and subsequent prevention of relapse of narcotic use in a patient in need of such treatment;
an electronics module, coupled to said bioactive substance module, said electronics module comprising a processor, a transponder and a memory, said memory configured for storing data related to said bioactive substance;
a power source coupled to said bioactive substance module and said electronics module;
(b) establishing a unique device ID in said memory by the manufacturer and setting a first flag in said memory by the manufacturer;
(c) conveying said ingestible drug delivery device to a pharmacist, the pharmacist communicating with said ingestible drug delivery device using a programming terminal to store data related to the pharmacist and a patient ID authorized to ingest said ingestible drug delivery device in said memory and to set a second flag in said memory;
(d) selecting a patient in need of treatment of withdrawal from narcotics and subsequent prevention of relapse of narcotic use;
(e) administering said at least one ingestible delivery device to the patient based on need of treatment of withdrawal from narcotics and subsequent prevention of relapse of narcotic use, the patient having a patient interface device that communicates with said ingestible drug delivery device to provide said patient ID to said ingestible drug delivery device;
(f) analyzing, by said processor, to determine:(i) that said first flag is set;(ii) that said second flag is set; and(iii) that said patient ID provided by said patient interface device matches said patient ID provided by the pharmacist; and(g) dispensing said at least one bioactive substance to the patient only if said first and second flags are set and said patient ID provided by said patient interface device matches said patient ID provided by the pharmacist and disabling the dispensing of said at least one bioactive substance if either one of said first or second flags is not set or if no match is determined by said processor between said patient ID provided by said patient interface device and said patient ID provided by the pharmacist; and
wherein subsequent to the administration, the patient withdrawal from narcotics is treated and subsequent relapse of narcotic use is prevented.

US Pat. No. 10,245,322

NANOSTRUCTURED CARRIERS FOR GUIDED AND TARGETED ON-DEMAND SUBSTANCE DELIVERY

The Regents of the Univer...

1. A nanostructure device for carrying a payload, comprising:an interior particle structure that includes an opening to an internal cavity of the interior particle structure;
an exterior shell structure at least partially formed on an exterior surface of the interior particle structure;
a plurality of magnetic nanoparticles within the exterior shell structure;
a functionalization layer on a surface of the internal cavity capable of chemically attaching a molecular payload to the interior particle structure,
wherein the magnetic nanoparticles are structured to interact with an external magnetic field to magnetically steer the nanostructure device; and
a capping particle attached to the interior particle structure to cover the opening and enclose the molecular payload within the internal cavity, wherein attachment of the capping particle to the interior particle structure allows controllable movement of the capping particle to expose the opening based on a release stimulus, wherein the capping particle is attached to the interior particle structure by molecular self-assembly of a self-assembled monolayer (SAM) formed on the surface of the capping particle, or by a nucleic acid having two strands of a complementary sequence of nucleotides.

US Pat. No. 10,245,296

COMPOSITIONS INCLUDING GINGER FOR THE AMELIORATION OR PREVENTION OF INFLAMMATORY CONDITIONS

Colgate-Palmolive Company...

1. A method for treating inflammation or an inflammatory disorder in a companion animal in need thereof, comprising:measuring a baseline level of expression of one or more inflammatory biomarkers in the companion animal in need thereof;
treating the companion animal in need thereof by administering to the companion animal a pet food composition comprising an effective amount of ginger to treat the inflammation or inflammatory disorder in the companion animal, wherein the inflammatory disorder is arthritis; and
measuring a change in the level of expression of the one or more inflammatory biomarkers relative to the baseline level of expression in the companion animal in need thereof, thereby indicating treatment of the inflammation or the inflammatory disorder,
wherein the companion animal is a cat, and wherein measuring the change in the level of expression of the one or more biomarkers relative to the baseline level of expression consists of measuring an increase in biomarker C-propeptide of type II collagen (CPII).

US Pat. No. 10,245,285

BLOOD PLASMA AND PLASMA FRACTIONS AS THERAPY FOR TUMOR GROWTH AND PROGRESSION

Alkahest, Inc., San Carl...

1. A method of treating a subject for thymic cancer, the method comprising:administering an effective amount of a blood plasma product to the subject diagnosed with thymic cancer to treat the subject for thymic cancer.

US Pat. No. 10,245,270

SALT OF 3-[(3-{[4-(4-MORPHOLINYLMETHYL)-1H-PYRROL-2-YL]METHYLENE}-2-OXO-2,3-DIHYDRO-1H-INDOL-5-YL)METHYL]-1,3-THIAZOLIDINE-2,4-DIONE, ITS PREPARATION, AND FORMULATIONS CONTAINING IT

LES LABORATOIRES SERVIER,...

1. E isomer of 3-[(3-{[4-(4-morpholinylmethyl)-1H-pyrrol-2-yl]methylene}-2-oxo-2,3-dihydro-1H-indol-5-yl)methyl]-1,3-thiazolidine-2,4-dione methanesulphonate of formula (II):
having an X-ray powder diffractogram which exhibits the Bragg's angles 2 theta (expressed in terms of °+0.2) 7.55; 10.42; 14.84; 15.06; 15.25; 15.80; 16.81; 17.01; 17.95; 19.06; 20.00; 20.29; 21.88; 23.87; 24.31; 24.64; 26.13; 26.59.

US Pat. No. 10,245,267

BIARYL AMIDE COMPOUNDS AS KINASE INHIBITORS

Novartis AG, Basel (CH)

1. A compound, or a pharmaceutically acceptable salt thereof, selected from:

US Pat. No. 10,245,266

3-(4-((4-MORPHOLINOMETHYL-BENZYL)OXY)-1-OXOISOINDOLIN-2-YL)PIPERIDINE-2,6-DIONE FOR THE TREATMENT OF SYSTEMIC LUPUS ERYTHEMATOSUS

Celgene Corporation, Sum...

1. A method for identifying a subject having systemic lupus erythematosus (SLE) who is likely to be responsive to a treatment with a compound of formula Ior a pharmaceutically acceptable salt, stereoisomer, tautomer or racemic mixture thereof, comprising:(a) determining the level of a biomarker in a first sample from the subject, wherein the biomarker is selected from the group consisting of CRBN, IKZF1 (Ikaros), and IKZF3 (Aiolos); and
(b) comparing the level of the biomarker in the first sample to a reference level of the biomarker; wherein the subject is likely to be responsive to the treatment if the level of the biomarker in the first sample is higher than the reference level of the biomarker.

US Pat. No. 10,245,264

SUBSTITUTED IMIDAZO[1,2-A]PYRAZINES AS SOLUBLE GUANYLATE CYCLASE ACTIVATORS

12. A pharmaceutical composition comprising the compound of claim 1, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier.

US Pat. No. 10,245,262

IMMUNOLOGICAL REAGENTS AND USES THEREFOR

The University of Queensl...

1. An MR1-ligand subunit [MR1-L] which binds MAIT cells, wherein said ligand is represented by Formula (I):
or a salt, tautomer, or stereoisomer thereof
wherein:
R1 is selected from the group consisting of:
X—C(O)—R1? (where R1? is H, or optionally substituted C1-C6alkyl, and X is independently a bond or a divalent linker selected from the group consisting of C1-C3 optionally substituted alkylene, —NR2?— optionally substituted C1-C3alkylene-, —O— optionally substituted C1-C3alkylene-, —S— optionally substituted C1-C3alkylene-, —S(O)— optionally substituted C1-C3alkylene-, —N?CR2?—, —CR2??CR2?—, —NR2?—C(O)—, —O—C(O)—, or —S—C(O)— where each R2? and R2? is independently selected from H, halogen, CN, or optionally substituted C1-C6alkyl); —X?—C(O)NR3?R4? (where R3? is H or optionally substituted C1-C6alkyl and R4? is optionally substituted C1-C6alkyl, OH, or CN or R3?R4? together form an optionally substituted heterocyclyl or optionally substituted heteroaryl, and X? is independently a bond or a C1-C3 optionally substituted alkylene); —X?—C(O)OR5? (wherein R5? is H or optionally substituted C1-C6alkyl, and X? is independently a bond or a C1-C3 optionally substituted alkylene); —X??—C(O)NHSO2R6? (wherein R6? is optionally substituted aryl, or optionally substituted C1-C6alkyl, and X?? is independently a bond or a C1-C3 optionally substituted alkylene); and —X??—S(O)2NHR7? (wherein R7? is H, optionally substituted C1-C6alkyl, or optionally substituted aryl, and X?? is independently a bond or a C1-C3 optionally substituted alkylene);
R2 is selected from the group consisting of optionally substituted C1-8alkyl, —NH(optionally substituted C1-6alkyl), —N(optionally substituted C1-6alkyl)(optionally substituted aryl), —N(optionally substituted C1-6alkyl)2, —O(optionally substituted C1-6alkyl), —OC(O)(C1-6alkyl), —S(optionally substituted C1-6alkyl), —SC(O)(C1-6alkyl), and —S(O)(optionally substituted C1-6alkyl); and
Y and Z are oxo.

US Pat. No. 10,245,259

METHODS OF TREATING RBP4 RELATED DISEASES WITH TRIAZOLOPYRIDINES

Belite Bio, Inc, (KY)

1. A method of treating a metabolic disease or disorder in a subject in need thereof, the method comprising administering to the subject a composition comprising a therapeutically effective amount of a compound of Formula (I), or a pharmaceutically acceptable salt thereofwherein:each R1 is independently halogen, haloalkyl, or alkyl;
R2 is —H, —OH, or halogen;
p is 0, 1, 2, 3, 4, or 5; and
A has the structure:

wherein:
?, ?, ?, and ? are each independently absent or present, and when present each is a bond;
X is N;
Z1 is S, O, or N;
Z2 is S, O, N, or NR3;
R3 is H, C1-C4 alkyl, or oxetane; and
B is a substituted or unsubstituted fused 5-, 6-, or 7-membered ring structure; and
wherein the metabolic disease or disorder is non-alcoholic fatty liver disease (NAFLD) or non-alcoholic steatohepatitis (NASH).

US Pat. No. 10,245,258

TREATMENT OF A HEMATOLOGIC MALIGNANCY WITH 2-(4-CHLOROPHENYL)-N-((2-(2,6-DIOXOPIPERIDIN-3-YL)-1-OXOISOINDOLIN-5-YL)METHYL)-2,2-DIFLUOROACETAMIDE

Celgene Corporation, Sum...

1. A method for treating, managing, or ameliorating a hematological cancer comprising administering to a subject in need thereof 2-(4-chlorophenyl)-N-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl)methyl)-2,2-difluoroacetamide, which has the following structure:or a stereoisomer or mixture of stereoisomers, isotopologue, pharmaceutically acceptable salt, tautomer, solvate, hydrate, co-crystal, clathrate, or polymorph thereof (Compound 1), wherein Compound 1 is administered to the subject in a dose of about 0.1 mg to about 20 mg, and the subject is further administered one or more of calcium, calcitriol, or vitamin D supplementation.

US Pat. No. 10,245,256

NITROXIDES FOR USE IN TREATING OR PREVENTING DIABETES AND OBESITY

Mitos Pharmaceuticals, In...

1. A method of treatment comprising:identifying a subject having elevated TNFa levels, and
administering to the subject an amount of a nitroxide antioxidant effective to reduce said levels in the subject, wherein the nitroxide antioxidant is selected from the following formulas:

wherein X is selected from O— and OH, and R is selected from COOH, CONH2, CN, and CH2NH2;

wherein X is selected from O— and OH, and R1 is CH3, R2 is C2H5, or R1 and R2 taken together are spirocyclohexyl;

wherein X is selected from O— and OH and R is selected from CONH2; and

wherein X is selected from O— and OH and R is selected from H, OH, and NH2, or wherein the nitroxide antioxidant is selected from the group consisting of 4-Oxo-2,2,6,6-tetramethylpiperidine-1-oxyl, 4-(2-bromoacetamido)-2,2,6,6-tetramethylpiperidine-1-oxyl, 4-(ethoxyfluorophosphonyloxy)-2,2,6,6-tetramethylpiperidine-1-oxyl, 4-hydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl, 4-(2-iodoacetamido)-2,2,6,6-tetramethylpiperidine-1-oxyl, 4-isothiocyanato-2,2,6,6-tetramethylpiperidine-1-oxyl, 4-maleimido-2,2,6,6-tetramethylpiperidine-1-oxyl, 4-(4-nitrobenzoyloxyl)-2,2,6,6-tetramethylpiperidine-1-oxyl, and 4-phosphonooxy-2,2,6,6-tetramethylpiperidine-1-oxyl.

US Pat. No. 10,245,255

COMPOSITIONS AND METHODS FOR THE TREATMENT OF OBESITY AND RELATED DISORDERS

THE REGENTS OF THE UNIVER...

1. A method of treating a human subject having a condition associated with obesity, insulin resistance, or hepatic steatosis by inhibiting TBK1 and/or IKK? consisting essentially of administering an orally effective amount of amlexanox, or a pharmaceutically acceptable salt thereof, to a human subject having a condition associated with obesity, insulin resistance, or hepatic steatosis, wherein the subject does not have an allergy, an aphthous ulcer, or bronchial asthma, and wherein the administering causes a reduction of body fat in the subject.

US Pat. No. 10,245,254

GLUTAMINASE INHIBITORS

Cornell University, Itha...

1. A compound, or a pharmaceutically acceptable salt thereof, of structure:wherein A is a piperidinyl;Y1 and Y2 are each independently N or C with the proper valency;
X1 and X2 are each independently —NH—, —O—, —CH2—O—, provided that when at least one of X1 and X2 is —CH2—O—, then the —CH2— is directly connected to A;
a and b are each independently 0 or 1;
c and d are each independently 0 or 1;
Z1 and Z2 are each independently selected from thiadiazole, pyridazine, or pyridine; and
R1 and R2 are each independently optionally substituted alkyl, optionally substituted aralkyl, optionally substituted cycloalkyl, amino, optionally substituted heteroaralkyl, optionally substituted alkylalkoxy, optionally substituted alkylaryloxy, optionally substituted aryl, optionally substituted heteroaryl, or optionally substituted heterocycloalkyl;
provided that if Y1 is N and Y2 is C, then a=0 and b=1;
provided that if Y1 is C and Y2 is N, then a=1 and b=0;
provided that if c=0 and d=0, then R1 and R2 are both amino;
provided that if c is 1 and d is 1, then both R1 and R2 are not amino;
provided that if c is 0 and d is 1, then R1 is amino and R2 is optionally substituted alkyl, optionally substituted aralkyl, optionally substituted cycloalkyl, optionally substituted heteroaralkyl, optionally substituted alkylalkoxy, optionally substituted alkylaryloxy, optionally substituted aryl, optionally substituted heteroaryl, or optionally substituted heterocycloalkyl; and
provided that if c is 1 and d is 0, then R2 is amino and R1 is optionally substituted alkyl, optionally substituted aralkyl, optionally substituted cycloalkyl, optionally substituted heteroaralkyl, optionally substituted alkylalkoxy, optionally substituted alkylaryloxy, optionally substituted aryl, optionally substituted heteroaryl, or optionally substituted heterocycloalkyl.

US Pat. No. 10,245,252

USE OF ALKYLAMIDOTHIAZOLES IN COSMETIC OR DERMATOLOGICAL PREPARATIONS FOR THE PROPHYLAXIS OR TREATMENT OF SENSITIVE SKIN

BEIERSDORF AG, Hamburg (...

1. A method for the treatment or prophylaxis of sensitive skin, itching, dry skin, as well as of inflammatory states of the human skin, wherein the method comprises applying to skin of a subject in need thereof a cosmetic or dermatological preparation comprising one or more alkylamidothiazoles of the following formula in an amount which is effective for the treatment or prophylaxis of sensitive skin, itching, dry skin, inflammatory states of the human skin:
in which
R1, R2, X and Y are different, partly identical or completely identical and, independently of one another, represent:
R1=—C1-C24-alkyl (linear and branched), —C1-C24-alkenyl (linear and branched), —C1-C8-cycloalkyl, —C1-C8-cycloalkyl-alkylhydroxy, —C1-C24-alkylhydroxy (linear and branched), —C1-C24 alkylamine (linear and branched), —C1-C24-alkylaryl (linear and branched), —C1-C24-alkylaryl-alkyl-hydroxy (linear and branched), —C1-C24-alkylheteroaryl (linear and branched), —C1-C24-alkyl-O—C1-C24-alkyl (linear and branched), —C1-C24 alkyl-morpholino, —C1-C4 alkyl-piperidino, —C1-C24 alkyl-piperazino, or —C1-C24 alkyl-piperazino-N-alkyl;
R2=H, —C1-C24-alkyl (linear and branched), —C1-C24-alkenyl (linear and branched), —C1-C8-cycloalkyl, —C1-C24-hydroxyalkyl (linear and branched), —C1-C24-alkylaryl (linear and branched), or —C1-C24-alkylheteroaryl (linear and branched);
X=-phenyl, optionally mono- or polysubstituted with —OH, —F, —Cl, —Br, —I, —OMe, —NH2, —CN, or cetyl;
Y=H, —C1-C24-alkyl (linear and branched), —C1-C24-alkenyl (linear and branched), —C1-C8-cycloalkyl, —C1-C24-aryl, —C1-C24-heteroaryl, —C1-C24-alkylaryl (linear and branched), —C1-C24-alkylheteroaryl (linear and branched), -phenyl, -2,4-dihydroxyphenyl, -2,3-dihydroxyphenyl, -2,4-dimethoxyphenyl, -2,3-dimethoxyphenyl, —COO-alkyl, —COO— alkenyl, —COO-cycloalkyl, —COO-aryl, or —COO-heteroaryl;
and wherein the one or more alkylamidothiazoles are present as a free base and/or as a cosmetically and dermatologically acceptable salt thereof.

US Pat. No. 10,245,251

SYNERGISTIC PHARMACEUTICAL COMBINATION FOR THE TREATMENT OF SQUAMOUS CELL CARCINOMA OF HEAD AND NECK

PIRAMAL ENTERPRISES LIMIT...

1. A method for the treatment of squamous cell carcinoma of head and neck in a subject comprising administering to said subject a therapeutically effective amount of:a CDK inhibitor of formula I:

wherein Ar is 2-chloro-4-trifluoromethylphenyl; or a pharmaceutically acceptable salt or solvate thereof; and
a therapeutically effective amount of one or more antineoplastic agents selected from sorafenib, and lapatinib.

US Pat. No. 10,245,249

PHARMACEUTICAL COMPOSITIONS COMPRISING NITROXYL DONORS

Cardioxyl Pharmaceuticals...

1. A pharmaceutical composition comprising a N-hydroxysulfonamide type nitroxyl donor and an aqueous buffer, wherein the N-hydroxysulfonamide type nitroxyl donor is a compound of the formula (1)andwherein the composition has a pH of from about 5 to about 6.5.

US Pat. No. 10,245,248

FAP-ACTIVATED THERAPEUTIC AGENTS, AND USES RELATED THERETO

BACH BIOSCIENCES, LLC, C...

1. A prodrug represented by the general formula
or a pharmaceutically acceptable salt thereof, wherein:R1 represents (C1-C10)alkyl, (C1-C10)alkoxy, (C1-C10)alkyl-C(O)—(C1-C10)alkyl, (C3-C8)cycloalkyl, (C3-C8)cycloalkyl(C1-C10)alkyl, aryl, aryl(C1-C10)alkyl, heteroaryl, or heteroaryl(C1-C10)alkyl, wherein any R1 is optionally substituted with one or more substituents independently selected from the group consisting of halo, hydroxy, carboxylate, cyano, amino, nitro, and thio (—SH); or —C(?X)R1 represents an N-terminally blocked alpha amino acid residue and X is O;R2 represents H or a (C1-C6)alkyl;R3 represents a (C1-C6)alkyl;R4 is absent or represents one, two or three substituents, each independently selected from a (C1-C6)alkyl, —OH, —NH2, or halogen;X represents O or S;Cyt?, or Cyt?L-NH, represents a cytotoxic compound or cytostatic compound, less a hydrogen atom; andL represents a 4- to 8-membered ring which is part of the cytotoxic compound or cytostatic compound and is recognized by FAP as a P?1 residue; or L is a self-immolative linker which is metabolized after FAP cleavage to release Cyt?,wherein the prodrug is selectively converted to the cytotoxic compound or cytostatic compound by FAP+ stromal cells.

US Pat. No. 10,245,247

OMEGA-3 FATTY ACID ARTICLES OF MANUFACTURE, AND METHODS AND APPARATUS FOR MAKING SAME

AMBO INNOVATIONS, LLC, O...

1. An article of manufacture comprising a lipid resulting from a source of omega-3 fatty acids co-processed with a hydrophilic flavonoid, a lipophilic anti-oxidant, and melatonin in a concentration effective to inhibit lipid destroying enzymes.

US Pat. No. 10,245,240

TREATMENT OF PROSTATE CARCINOMA

PELLFICURE PHARMACEUTICAL...

1. A method of inhibiting or delaying the growth of prostate cancer, comprising administering to a human having prostate cancer a therapeutically effective amount of a compound of Formula (I) or a pharmaceutically acceptable salt of Formula (I):
wherein:
R1 is methyl;
R2 is hydrogen;
R3 is —OH;
R4 is hydrogen;
R5 is hydrogen;
R6 is hydrogen; and
wherein the compound of Formula (I) is administered to the human in combination with, subsequent to, or concomitantly with, an androgen deprivation therapy that reduces production of dihydrotestosterone (DHT), androsterone, androstenediol, androstenedione, dehydroepiandrosterone (DHEA), or dehydroepiandrosterone sulfate (DHEA-S); and wherein the growth of prostate cancer is inhibited or delayed.

US Pat. No. 10,245,234

METHOD OF TREATING CANCER WITH EDIBLE OIL DERIVED EXCIPIENTS

1. A method of treating breast cancer consisting intravenously administering to a subject in need thereof a therapeutically effective amount of substantially ethanol free nanoparticle composition wherein nanoparticle composition consists nanoparticles having hydrodynamic diameter of 10 to 200 nm consisting 1 to 10 percent by weight of a taxane and 90 to 99 percent by weight of a substantially hydroxyl free unsaturated oil saturated at least at one site of unsaturation by a covalently attached hydrogen atom and a covalently attached water soluble polymer of formula—S—(CH2)n—S-X-POLYwherein n is an integer selected from 2 to 12,X is thiol reactive linker containing functionalities selected from a group consisting maleimido, acrylate, methacrylate, isocyanate, isothiocyanate, iodoacetamido, bromoacetamido, sulfovinyl, thioether,
POLY is substantially biocompatible water soluble polymer selected from a group consisting polyethylene glycol, polyethylene oxide, polyethylene glycol methyl ether, homo and heterobifuctional polyethylene glycols, polyethylene glycol-co-polypropylene glycol, polyethylene oxide-block-polypropylene oxide, polyethylene glycol-acrylate, polyethylene glycol-methacrylate, methoxypolyethylene glycol-acrylate, methoxypolyethylene glycol-methacrylate, poly(polyethyleneglycol-metahcrylate)s, poly(methoxypolyethyleneglycol-methacrylate)s, poly(N-2-hydroxypropylmethacrylamide), poly(N-vinylpyrrolidone), poly(N-isopropylacrylamide), poly(acrylic acid), poly(methacrylic acid), poly(2-aminoethyl methacrylate), poly(N,N-dimethylaminoethyl methacrylate), poly(2-methacryloyloxyethylphosphorylcholine) and combinations thereof,
substantially hydroxyl free unsaturated oil is oil selected from a group of edible oils consisting olive oil, corn oil, canola oil, soybean oil, rapeseed oil, linseed oil, trilinolein, triolein, peanut oil, sunflower oil, mustard oil, almond oil, palm oil, sesame oil, safflower oil, cottonseed oil, grape seed oil, rice bran oil, mono, di, triglycerides of unsaturated fatty acids of C7 to C22 chain length, unsaturated fatty acids of C7 to C22 chain length, and mixtures thereof,
and taxane is selected from a group consisting paclitaxel, docetaxel, cabazitaxel.

US Pat. No. 10,245,233

CONTROLLED RELEASE FROM PARTICLES ENCAPSULATED BY MOLECULAR LAYER DEPOSITION

Technische Universiteit D...

8. A method for the production of a slow-release material (1) according to claim 1, the method comprising:fluidizing particles (100) comprising an active component (10) in a reactor (1000), wherein the active component comprises one or more of a pharmaceutical compound and a nutraceutical compound;
applying molecular multi-layer deposition with self-terminating reactions on said fluidized particles (100) in said reactor (1000), wherein sequentially compounds (II) and (III) are reacted:
wherein R1, R2, R3, and R4 are independently selected from the group consisting of a carbon comprising group, wherein R2 is optionally present, wherein A1 and A2 are independently selected from OH, Cl, and —OR5, wherein R5 is selected from the group consisting of a carbon comprising group and a silicon comprising group, wherein Z11 and Z12 are each independently selected from an OH comprising group, an NH comprising group and an NH2 comprising group;removing the thus obtained particles from said reactor (1000), to provide said slow-release material (1).

US Pat. No. 10,245,225

OIL-FREE EMOLLIENTS IN SUNSCREEN COMPOSITIONS

Rohm and Haas Company, P...

1. A sunscreen composition comprising:(a) an oil-soluble polyalkylene glycol of Formula II:
wherein R is a linear or branched C8-C12 alkyl, n has an average value of from 5 to 20, and m has an average value of from 4 to 16, wherein the polyalkylene glycol has a number average molecular weight of from 500 to 5,000, and wherein the weight ratio of CH2CH(CH2CH3)O units to CH2CH(CH3)O units ranges from 4:1 to 1:4;(b) a dermatologically acceptable carrier, wherein the dermatologically acceptable carrier is selected from the group consisting of oil-in-water emulsions or water-in-oil emulsions; and
(c) a sunscreen active,wherein the polyalkylene glycol is present in an amount of from 2 to 10 weight %, based on the total weight of the composition.

US Pat. No. 10,245,223

USE FOR DYEING KERATIN FIBRES OF A COMPOUND OF AZOMETHINE TYPE BEARING A PYRAZOLOPYRIDINE UNIT

1. A compound chosen from dyes of azomethine type bearing a pyrazolopyridine unit of formula (I), leuco forms of formula (II) thereof, optical isomers and geometrical isomers thereof, tautomers thereof, addition salts thereof with an acid or a base, and solvates or hydrates thereof:wherein in formulae (I) and (II), independently:Z1 represents an oxygen atom or a group —NR6—; and when Z1 represents —NR6—, then R1 and R6 may form, together with the nitrogen atom to which they are attached, an optionally substituted, 5- to 8-membered, saturated, unsaturated or aromatic heterocycle;
R1 and R6 each independently represent:
a hydrogen atom;
a C1-C10 alkyl radical optionally interrupted with one or more non-adjacent heteroatoms, and/or optionally substituted, with one or more groups chosen from i) hydroxyl, ii) optionally substituted 5- to 8-membered, saturated, unsaturated or aromatic (hetero)cycle, iii) —N(R?)R?, iv) —N+R?R?R?? with R?, R? and R?? each independently representing a C1-C6 alkyl group; or
an optionally substituted, saturated, unsaturated or aromatic 5- to 8-membered (hetero)cycle;
R2, R3, R4 and R5 each independently represent:
a hydrogen atom;
an optionally substituted C1-C4 alkyl radical; or
a group chosen from —NH2, —N(H)R10, —N(R11)—R12, —OH and —OR9, with R9 and R10 representing an optionally substituted, linear or branched C1-C6 alkyl, R11 and R12, which may be identical or different, representing an optionally substituted, linear or branched C1-C6 alkyl, it being optional for R11 and R12 to form, together with the nitrogen atom to which they are attached, a saturated, unsaturated or aromatic 5- to 8-membered heterocycle optionally containing one or more other heteroatoms or groups chosen from oxygen and nitrogen, the heterocycle being optionally substituted;
R2, R3, R4 and R5 may form, in pairs, with adjacent radicals, an optionally substituted, saturated or unsaturated or aromatic (hetero)cycle;
R?2 and R?3, which may be identical or different, represent:
a hydrogen atom;
a C1-C6 alkyl radical, optionally substituted with one or more hydroxyl radicals;
a C1-C6 alkyl carboxylate radical; or
a carboxyl radical;
R? represents:
a hydrogen atom;
a C1-C6 alkyl radical;
R?6 represents:
a hydrogen atom;
a halogen atom;
a linear or branched C1-C10 alkyl radical, optionally interrupted with one or more non-adjacent oxygen atoms and/or one or more non-adjacent divalent groups —N(R?9)— and optionally substituted with one or more radicals, which may be identical or different, chosen from —OH and —N(R?7)R?8;
a carboxyl radical;
a C1-C10 alkyl carboxylate;
a radical CONR?7R?8;
a C1-C10 alkoxy radical or a C1-C10 (poly)hydroxyalkoxy radical;
a (poly)(C1-C10 alkoxy)-(C1-C10 alkoxy) radical; or
a radical —O-Ak-N(R?9)R?10 in which Ak is a linear C1-C8 or branched C3-C8 divalent alkylene radical, optionally interrupted with one or more oxygen atoms and/or non-adjacent divalent groups —N(R?7)—;
R?7 and R?8, which may be identical or different, represent:
a hydrogen atom; or
a C1-C8 alkyl radical optionally substituted with one or more hydroxyl radicals;
R?9 and R?10, which may be identical or different, represent i) a linear or branched C1-C6 alkyl radical, ii) a C2-C6 alkenyl radical or iii) a C2-C6 alkynyl radical;
R?9 and R?10 may form, with the nitrogen that bears them, a saturated or unsaturated 5- to 8-membered heterocycle, one of the chain members optionally being an oxygen atom or a nitrogen atom, or a divalent radical —N(R?11)— with R?11 representing a hydrogen atom or a C1-C4 alkyl group, optionally substituted with one or more radicals chosen from —OH, —N(R?7)R?8 and C1-C4 alkyl;
R? represents:
a hydrogen atom; or
a linear or branched C1-C10 alkyl radical, optionally interrupted with an oxygen atom or a divalent group —N(R)— with R representing a hydrogen atom or a C1-C4 alkyl group;
wherein when the compound of formula (I) or (II) is positively charged, then it comprises as many anionic counterions as cationic charges to achieve the electrical neutrality of the molecule.

US Pat. No. 10,245,221

STABILIZED COLOR DEPOSITING SHAMPOO

Celeb LLC, Davie, FL (US...

1. A one-part coloring depositing shampoo composition for human hair comprising:at least one cationic dye;
a nonionic surfactant that is n-methyl alkyl glucamide with carbon chain lengths between 8 and 20;
an aqueous carrier;
a stablizer comprising a combination of Di-t-butyl-4-hydroxyhydrocinnamate and Tris (Tetramethylhydroxypiperidinol) Citrate;
wherein said composition does not contain any anionic surfactant.

US Pat. No. 10,245,219

METHOD FOR THE REMOVAL OF TATTOOS AND SKIN DISCOLOURATION

1. A method for removal of tattoos or skin discoloration, the method comprising:applying from about 0.02 ml to about 0.5 ml of a removal fluid to a pigmentation device to form a wetted pigmentation device, the wetted pigmentation device comprising one or more needles; and
with the wetted pigmentation device, forming a treatment area by contacting the one or more needles to an epidermis while traversing a path defining a circumference a maximum of 3 to 4 times in about 10-15 seconds to remove at least a portion of the epidermis bounded by the circumference,
wherein the removal fluid from the wetted pigmentation device enters the treatment area during the forming the treatment area.

US Pat. No. 10,245,216

SYSTEMS, METHODS, AND APPARATUSES FOR MANAGING ADHERENCE TO A REGIMEN

1. A device that removably attaches to a medication container, the device comprising:a housing;
a transducer for notifying a user;
one or more container opening detectors configured to detect when the medication container is opened;
a processor;
a memory configured to store medication information and activity information;
a communication module; and
a connector for attaching the device to the container;
wherein the communication module is configured to send the stored activity information to a user device at a calculated time, wherein the calculated time is determined based on a parameter selected from the group consisting of a user sleep schedule, a user medication schedule, and a time of at least one prior successful transmission of information from the attachable device to the user device.

US Pat. No. 10,245,215

PILL CUTTING AND STORAGE DEVICE

Tyson Triplett, Provo, U...

1. An apparatus, the apparatus comprising:a base;
a fixed member attached to the base, the fixed member comprising a first cutting wedge;
a lever arm pivotably attached to one or more of the base and the fixed member at a pivot point, the lever arm comprising a second cutting wedge, the lever arm positionable between an open position and a closed position, wherein the lever arm rotates to move the second cutting wedge to contact the first cutting wedge where a cutting surface of the first cutting wedge aligns with a cutting surface of the second cutting wedge when the lever arm is in the closed position, wherein the cutting surface of the first cutting wedge and the cutting surface of the second cutting wedge are oriented parallel to an axis of rotation of the pivot point, and wherein the base, the fixed member, and the lever arm form, in a closed position, a first compartment on a first side of the first and second cutting wedges and form a second compartment, separate from the first compartment, on a second side of the first and second cutting wedges, the first side opposite the second side, wherein the base forms a bottom to the first and second compartments; and
a cover positionable over only one side of the first and second compartments formed by the base, the fixed member, and the lever arm, wherein the first and second compartments are enclosed when the cover is positioned over the first and second compartments and the lever arm is in the closed position, wherein the cover is separately pivotable from the lever arm.

US Pat. No. 10,245,213

DEVICE FOR RECONSTITUTING A PHARMACEUTICAL COMPOSITION

EVEON, (FR)

1. A device for reconstituting a pharmaceutical composition from at least a first component contained in a first container and a second component contained in a second container, comprising:a fluidic unit; and
a power unit releasably coupled to the fluidic unit,wherein the fluidic unit comprises:a first connector comprising a body defining an axial chamber and a rotatable crankpin arranged in the axial chamber, the crankpin comprising a mounting interface configured to mechanically couple to the first container, the crankpin further comprising an axial port configured to fluidically couple to the first container when said first container engages the mounting interface, and a radial port fluidically connected to the axial port of the first connector;
a second connector configured to mechanically and fluidically couple to the second container, the second connector comprising an axial port to fluidically couple to the second container when said second container engages the second connector and a radial port in fluidic link with the axial port of the second connector;
a pump; and
a fluidic circuit comprising channel portions connecting the first connector, the second connector and the pump;
wherein the body of the first connector comprises at least three radial ports connected to the fluidic circuit,
wherein the crankpin comprises at least one channel configured to cooperate with the at least three radial ports of the body of the first connector to selectively connect the axial port of the first connector with at least one channel portion of the fluidic circuit depending on the angular position of the crankpin with respect to the body, and
wherein the power unit comprises:
a power mechanism for actuating the pump; and
transmission means adapted to be connected between an actuator and the crankpin for rotating the first container.

US Pat. No. 10,245,209

SYSTEMS AND METHODS FOR GRAVITY-ASSISTED CARDIOPULMONARY RESUSCITATION

1. A method, comprising:performing CPR with at least the head of an individual elevated by bending the individual at the waist to at least 20 degrees relative to horizontal while the individual's legs are generally aligned with a horizontal plane, wherein CPR is performed with an automated device that compresses the chest while the head is elevated; and
interfacing a device for regulating the intrathoracic pressure with the individual:
wherein the automated device includes a band that is positioned around the thorax of the individual;
wherein the band around the thorax tightens with each compression and relaxes with each decompression, and
wherein the band around the thorax tightens when at least the head is elevated.

US Pat. No. 10,245,206

PNEUMATIC SOMATOSENSORY STIMULATION DEVICE AND METHOD

1. A device for providing tactile stimulation via a pulse of compressible fluid, said tactile stimulation device comprising:a high pressure fluid source;
a low pressure fluid source;
an outlet conduit being fluidly connectable to the fluid sources and including an applicator configured to direct the pulse against a first area of skin of a subject;
a pressure valve fluidly interposed between the applicator and the fluid sources,
said pressure valve being shiftable between a high pressure position, in which the high pressure fluid source is fluidly connected to the outlet conduit, and a low pressure position, in which the low pressure fluid source is fluidly connected to the outlet conduit, with positioning of the pressure valve in the high pressure position and the low pressure position supplying the pulse of compressible fluid to the applicator;
a vacuum pressure source; and
a vacuum valve shiftable between a vacuum position, in which the vacuum pressure source is fluidly connected to the outlet conduit, and a pulse position, in which the vacuum pressure source is not fluidly connected to the outlet conduit.

US Pat. No. 10,245,205

SCRATCHING IMPLEMENT

1. A scratching implement, comprising:an elongated shaft having a first end and a second end such that the second end is more narrow than the first end;
a handle disposed towards said first end of said elongated shaft, the handle including a cylindrical crossbar transversely affixed across the elongated shaft;
a ring disposed on said first end distal to the handle, such that both the ring and the handle are configured to be cooperatively manipulated when maneuvering the elongated shaft; the ring being further adapted for use in securing said elongated shaft to a support surface or keyring;
said second end adapted for use in scratching a user's scalp;
further comprising a removable cover having an indentation thereon configured to receive and removably secure said elongated shaft and the cylindrical crossbar therein; and wherein said ring extends beyond said removable cover and is not removably secured within said indentation.