US Pat. No. 10,889,583

PESTICIDALLY ACTIVE HETEROCYCLIC DERIVATIVES WITH SULPHUR AND HYDROXYLAMINE SUBSTITUENTS

Syngenta Participations A...

1. A compound of formula Z-1
R2 is CF3;
R4 is unsubstituted alkyl;
X1 is halogen or azido;
Ry is hydrogen or t-butyloxycarbonyl; and
Rz is C1-C4alkyl.

US Pat. No. 10,889,582

1H-PYRROLO [2,3-B] PYRIDINE DERIVATIVES AND THEIR USE AS KINASE INHIBITORS

1. A method for treating ovarian cancer, triple negative breast cancer, melanoma, neuroblastoma, or pancreatic cancer in a mammal subject in need thereof comprising administering to the mammal subject a therapeutically effective amount of a compound of formula (I):or a pharmaceutically acceptable salt thereof, wherein:each Z is independently (Alk)n-Rn-(Alk)n-X, wherein:
each Alk is independently (C1 to C12) alkylene or (C2 to C12) alkenylene, each of which is optionally substituted;
each n is independently 0 or 1;
each R is independently optionally substituted arylene, optionally substituted heteroarylene, optionally substituted cycloalkylene, optionally substituted heterocycle, —O—,
—S—, —(C?O)—, —(C?S)—, —SO2—, —C(?O)O—, —C(?O)NRA—, —C(?S)NRA—, —SO2NRA—, —NRAC(?O)—, —NRASO2—, or —NRA—, wherein RA is hydrogen, C1-C6 alkyl, —C1-C6 alkyl(cycloalkyl), C1-C6 alkyl(C1-C6 alkoxy), or C1-C6 alkoxy; and
each X is independently halogen, —H, —ORA, —NRARA, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted cycloalkyl, optionally substituted heterocycle, CN, or C(halogen)aHb, where a is 1, 2, or 3, and b is (3-a);
Y is phenyl optionally substituted with C1 to C6 alkyl or halogen; optionally substituted, bicyclic or tricyclic aryl; optionally substituted heteroaryl; optionally substituted cycloalkyl; or optionally substituted heterocycle; and
R1 is H or C1-C6 alkyl.

US Pat. No. 10,889,581

CYCLOPROPYL FUSED THIAZINE DERIVATIVES AS BETA-SECRETASE INHIBITORS AND METHODS OF USE

Amgen Inc., Thousand Oak...

1. A compound of Formula I
or a tautomer thereof, or a pharmaceutically acceptable salt of said compound or tautomer, wherein
A is N, CH, or CR4;
R1 is H, —CN, C1-6alkyl, C2-6alkenyl, —C1-4alkyl-C(O)NR1?R1?, —C1-4alkyl-C(O)-heterocycloalkyl, —(HC?CH)—C(O)NR1?R1?, —(HC?CH)—C(O)-heterocycloalkyl, —C(O)NR1?R1?, or —C(O)-heterocycloalkyl, wherein the C1-6alkyl and the C2-6alkenyl are (i) optionally substituted with one to three fluoro substituents or (ii) optionally substituted with CN, OH, methoxy, or a 5-membered nitrogen-containing heteroaryl, wherein the 5-membered nitrogen-containing heteroaryl is optionally substituted with C1-4 alkyl;
R1? is, independently, H or C1-4alkyl;
R2 and R2? are independently H or halogen;
R3 is C1-4alkyl, wherein the C1-4alkyl is optionally substituted with one to three fluoro substituents;
R4 is halogen;
R5 is H, C3-6cycloalkyl, phenyl, or 5- or 6-membered heteroaryl, wherein the phenyl or heteroaryl is optionally substituted with one to three substituents independently selected from halogen, —CN, C1-4alkyl, 2-propynyloxy, 2-butynyloxy, or oxazolylmethoxy.

US Pat. No. 10,889,580

SUBSTITUTED FUSED IMIDAZOLE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE THEREOF

vTv Therapeutics LLC, Hi...

1. A method of treating a disease comprising administering to a human subject a compound,wherein the disease is non-alcoholic steatohepatitis;
wherein the compound is a compound of Formula (I) or a pharmaceutically acceptable salt thereof

wherein
one of X1, X2, X3, and X4 is
and the remaining members of X1, X2, X3, and X4 are independently N or
G is hydrogen, —C1-8 alkyl, —C3-10 cycloalkyl, —C1-6 alkylene-C3-10 cycloalkyl, heterocyclyl, —C1-6 alkylene-C3-10 heterocyclyl, phenyl, heteroaryl, or NRh Rk, where the alkyl, alkylene, cycloalkyl, heterocyclyl, phenyl, and heteroaryl groups are optionally substituted one or more times with substituents independently selected from Rc;
L is —CH2—C(O)N(R6)—, —C(O)N(R6)—, —C(O)—O—, —SO2—, —C(O)—, heteroarylene optionally substituted one or more times with substituents independently selected from Rx, or heterocyclylene optionally substituted one or more times with substituents independently selected from Rx; or the group -L-G is -cyano;
R1 is hydrogen, Ra, phenyl, or heteroaryl, where the phenyl and heteroaryl groups are optionally substituted one or more times with substituents independently selected from Rx;
R2 is Rb;
R3 is hydrogen, —C1-6 alkyl, or —C1-6 alkylene-C3-10 cycloalkyl, where the alkyl, alkylene, and cycloalkyl groups are optionally substituted one or more times with substituents independently selected from Rz;
R4 is —C1-6 alkyl or —C1-6 alkylene-C3-10 cycloalkyl, where the alkyl, alkylene, and cycloalkyl groups are optionally substituted one or more times with substituents independently selected from Ry;
R6 is hydrogen, —C1-6 alkyl, —C1-6 alkylene-C3-10 cycloalkyl, where the alkyl, alkylene, and cycloalkyl groups are optionally substituted one or more times with substituents independently selected from Rx;
Ra is
a) -halogen,
b) —C1-6 alkyl,
c) —C3-10 cycloalkyl,
d) -heterocyclyl,
e) -cyano,
f) —CF3,
g) —OCF3,
h) —O—Rd,
i) —S(O)w—Rd,
j) —S(O)2O—Rd,
k) —NRdRe,
l) —C(O)—Rd,
m) —C(O)—O—Rd,
n) —OC(O)—Rd,
o) —C(O)NRdRe,
p) —C(O)-heterocyclyl,
q) —NRd C(O)Re,
r) —OC(O)NRd Re,
s) —NRd C(O)ORd, or
t) —NRd C(O)NRd Re,
where the alkyl, cycloalkyl, and heterocyclyl groups are optionally substituted one or more times with substituents independently selected from Ry;
Rb is
a) -halogen,
b) —C1-6 alkyl,
c) —C3-10 cycloalkyl,
d) -heterocyclyl,
e) -phenyl,
f) -heteroaryl,
g) -cyano,
h) —CF3,
i) —OCF3,
j) —O—Rf,
k) —S(O)w—Rf,
l) —S(O)2O—Rf,
m) —NRfRg,
n) —C(O)—Rf,
o) —C(O)—O—Rf,
p) —OC(O)—Rf,
q) —C(O)NRfRg,
r) —C(O)-heterocyclyl,
s) —NRf C(O)Rg,
t) —OC(O)NRf Rg,
u) —NRf C(O)ORf, or
v) —NRf C(O)NRf Rg,
where the alkyl, cycloalkyl, heterocyclyl, phenyl, and heteroaryl groups are optionally substituted one or more times with substituents independently selected from Rz;
Rc is
a) -halogen,
b) —C1-6 alkyl,
c) —C3-10 cycloalkyl,
d) -heterocyclyl,
e) -cyano,
f) —CF3,
g) —OCF3,
h) —O—Rh,
i) —S(O)w—Rh,
j) —S(O)2O—Rh,
k) —NRhRk,
l) —C(O)—Rh,
m) —C(O)—O—Rh,
n) —OC(O)—Rh,
o) —C(O)NRhRk,
p) —C(O)-heterocyclyl,
q) —NRh C(O)Rk,
r) —OC(O)NRh Rk,
s) —NRh C(O)ORk,
t) —NRh C(O)NRh Rk,
u) —NRh S(O)wRk,
v) -phenyl,
w) -heteroaryl, or
x) —O—(C1-4 alkylene)-O—(C1-4 alkylene)-N(Rh)C(O)—ORk,
where the alkylene, alkyl, cycloalkyl, heterocyclyl, phenyl, and heteroaryl groups are optionally substituted one or more times with substituents independently selected from Rx;
Rd and Re are independently hydrogen, C1-6 alkyl, or C3-10 cycloalkyl, where the alkyl and cycloalkyl groups are optionally substituted one or more times with substituents independently selected from Ry; or, if Rd and Re are both attached to the same nitrogen atom, together with that nitrogen atom may optionally form a heterocyclic ring selected from the group consisting of azetidino, pyrrolidino, pyrazolidino, imidazolidino, oxazolidino, isoxazolidino, thiazolidino, isothiazolidino, piperidino, piperazino, morpholino, thiomorpholino, and azepano, where each ring is optionally substituted one or more times with substituents independently selected from Ry;
Rf and Rg are independently hydrogen, C1-6 alkyl, C3-10 cycloalkyl, phenyl, or heteroaryl, where the alkyl, cycloalkyl, phenyl, and heteroaryl groups are optionally substituted one or more times with substituents independently selected from Rz; or, if Rf and Rg are both attached to the same nitrogen atom, together with that nitrogen atom may optionally form a heterocyclic ring selected from the group consisting of azetidino, pyrrolidino, pyrazolidino, imidazolidino, oxazolidino, isoxazolidino, thiazolidino, isothiazolidino, piperidino, piperazino, morpholino, thiomorpholino, and azepano, where each ring is optionally substituted one or more times with substituents independently selected from Rz;
Rh and Rk are independently hydrogen, C1-6 alkyl, C3-10 cycloalkyl, heterocyclyl, phenyl, or heteroaryl, where the alkyl, cycloalkyl, heterocyclyl, phenyl, and heteroaryl groups are optionally substituted one or more times with substituents independently selected from Rx; or, if Rh and Rk are both attached to the same nitrogen atom, together with that nitrogen atom may optionally form a heterocyclic ring selected from the group consisting of azetidino, pyrrolidino, pyrazolidino, imidazolidino, oxazolidino, isoxazolidino, thiazolidino, isothiazolidino, piperidino, piperazino, morpholino, thiomorpholino, and azepano, where each ring is optionally substituted one or more times with substituents independently selected from Rx;
Ry is
a) -halogen,
b) —NH2,
c) -cyano,
d) -carboxy,
e) -hydroxy,
f) -thiol,
g) —CF3,
h) —OCF3,
i) —C(O)—NH2,
j) —S(O)2—NH2,
k) oxo,
l) —C1-6 alkyl, optionally substituted one or more times with substituents selected independently from the group consisting of halogen, —OH, —O—C1-6 alkyl, —NH2, —NH—C1-6 alkyl, and —N(C1-6 alkyl)2,
m) -heterocyclyl optionally substituted one or more times with substituents selected independently from the group consisting of halogen, —OH, —O—C1-6 alkyl, —NH2, —NH—C1-6 alkyl, and —N(C1-6 alkyl)2,
n) —C3-10 cycloalkyl optionally substituted one or more times with substituents selected independently from the group consisting of halogen, —OH, —O—C1-6 alkyl, —NH2, —NH—C1-6 alkyl, and —N(C1-6 alkyl)2,
o) —O—C1-6 alkyl optionally substituted one or more times with substituents selected independently from the group consisting of halogen, —OH, —O—C1-6 alkyl, —NH2, —NH—C1-6 alkyl, and —N(C1-6 alkyl)2,
p) —O—C3-10 cycloalkyl optionally substituted one or more times with substituents selected independently from the group consisting of halogen, —OH, —O—C1-6 alkyl, —NH2, —NH—C1-6 alkyl, and —N(C1-6 alkyl)2,
q) —NH—C1-6 alkyl optionally substituted one or more times with substituents selected independently from the group consisting of halogen, —OH, —O—C1-6 alkyl, —NH2, —NH—C1-6 alkyl, and —N(C1-6 alkyl)2,
r) —N(C1-6 alkyl)2 optionally substituted one or more times with substituents selected independently from the group consisting of halogen, —OH, —O—C1-6 alkyl, —NH2, —NH—C1-6 alkyl, and —N(C1-6 alkyl)2,
s) —C(O)—C1-6 alkyl, optionally substituted one or more times with substituents selected independently from the group consisting of halogen, —OH, —O—C1-6 alkyl, —NH2, —NH—C1-6 alkyl, and —N(C1-6 alkyl)2,
t) —C(O)—O—C1-6 alkyl, optionally substituted one or more times with substituents selected independently from the group consisting of halogen, —OH, —O—C1-6 alkyl, —NH2, —NH—C1-6 alkyl, and —N(C1-6 alkyl)2,
u) —S—C1-6 alkyl, optionally substituted one or more times with substituents selected independently from the group consisting of halogen, —OH, —O—C1-6 alkyl, —NH2, —NH—C1-6 alkyl, and —N(C1-6 alkyl)2,
v) —S(O)2—C1-6 alkyl, optionally substituted one or more times with substituents selected independently from the group consisting of halogen, —OH, —O—C1-6 alkyl, —NH2, —NH—C1-6 alkyl, and —N(C1-6 alkyl)2,
w) —C(O)—NH—C1-6 alkyl, optionally substituted one or more times with substituents selected independently from the group consisting of halogen, —OH, —O—C1-6 alkyl, —NH2, —NH—C1-6 alkyl, and —N(C1-6 alkyl)2,
x) —C(O)—N(C1-6 alkyl)2, optionally substituted one or more times with substituents selected independently from the group consisting of halogen, —OH, —O—C1-6 alkyl, —NH2, —NH—C1-6 alkyl, and —N(C1-6 alkyl)2,
y) —S(O)2—NH—C1-6 alkyl, optionally substituted one or more times with substituents selected independently from the group consisting of halogen, —OH, —O—C1-6 alkyl, —NH2, —NH—C1-6 alkyl, and —N(C1-6 alkyl)2,
z) —S(O)2—N(C1-6 alkyl)2, optionally substituted one or more times with substituents selected independently from the group consisting of halogen, —OH, —O—C1-6 alkyl, —NH2, —NH—C1-6 alkyl, and —N(C1-6 alkyl)2,
aa) —NH—C(O)—C1-6 alkyl, optionally substituted one or more times with substituents selected independently from the group consisting of halogen, —OH, —O—C1-6 alkyl, —NH2, —NH—C1-6 alkyl, and —N(C1-6 alkyl)2, or
bb) —NH—S(O)2—C1-6 alkyl, optionally substituted one or more times with substituents selected independently from the group consisting of halogen, —OH, —O—C1-6 alkyl, —NH2, —NH—C1-6 alkyl, and —N(C1-6 alkyl)2;
Rx is
a) —Ry
b) -phenyl, optionally substituted one or more times with substituents selected independently from the group consisting of halogen, —OH, —O—C1-6 alkyl, —NH2, —NH—C1-6 alkyl, and —N(C1-6 alkyl)2,
c) -heteroaryl, optionally substituted one or more times with substituents selected independently from the group consisting of halogen, —OH, —O—C1-6 alkyl, —NH2, —NH—C1-6 alkyl, and —N(C1-6 alkyl)2,
d) —O-phenyl,
e) —O-heteroaryl,
f) —C(O)-phenyl,
g) —C(O)-heteroaryl,
h) —C(O)—O-phenyl, or
i) —C(O)—O-heteroaryl;
Rz is
a) —Ry
b) -phenyl,
c) -heteroaryl;
d) —O-phenyl,
e) —O-heteroaryl,
f) —C(O)-phenyl,
g) —C(O)-heteroaryl,
h) —C(O)—O-phenyl, or
i) —C(O)—O-heteroaryl;
v is an integer from 0 to 4, and
w is an integer from 0 to 2.

US Pat. No. 10,889,579

THIAZINE DERIVATIVES AS ?-SECRETASE INHIBITORS AND METHODS OF USE

Amgen Inc., Thousand Oak...

1. A compound of Formula I
or a tautomer thereof, or a pharmaceutically acceptable salt of said compound or tautomer, wherein
R1 and R1?, independently, are H, C1-6alkyl, —C(O)OC1-6alkyl, —C(O)NHC1-6alkyl, or —C(O)-heterocycloalkyl, wherein the C1-6alkyl and the C1-6alkyl portions of —C(O)OC1-6alkyl and —C(O)NHC1-6alkyl are optionally substituted with one to three fluoro substituents;
R2 and R2? are H;
b is a single bond, if R1, R1?, R2 and R2? are present;
b is a double bond, if one of R1 and R1? and one of R2 and R2? is not present;
R3 is C1-4alkyl;
R4 is halogen;
R5 is H or F; and
one of R6 and R7 is F or H and the other of R6 and R7 is a 6-membered nitrogen-containing heteroaryl, which heteroaryl is optionally substituted with halogen, —CN, or 2-propynyloxy, wherein at least one of R5, R6, or R7 is F.

US Pat. No. 10,889,578

PROCESS FOR PREPARING AMINOPYRIMIDINE DERIVATIVES

Yuhan Corporation, Seoul...

33. A compound, wherein said compound is 1-(2-(methylthio)pyrimidin-4-yl)-3-phenyl-1H-pyrazole-4-carbaldehyde.

US Pat. No. 10,889,577

SOLID FORMS OF AN SGC STIMULATOR

Cyclerion Therapeutics, I...

1. A crystalline solid form of Compound I:
wherein:(1) the crystalline solid form is crystalline free form Form E characterized by (i) peaks in the XRPD spectrum comprising: 7.4, 18.8-19.3, 21.1, 24.8 and 25.5 °2?; (ii) peaks in the XRPD spectrum comprising: 7.4, 13.9, 15.1, 16.3, 17.6, 18.8-19.3, 21.1, 22.3-22.5, 24.8, 25.5 and 27.1 °2?; (iii) an XRPD spectrum substantially similar to that shown in FIG. 2 or FIG. 6; (iv) a FT-Raman spectrum substantially similar to that shown in FIG. 10; (v) an IR spectrum that exhibits a peak maximum at 1690 cm?1; (vi) an IR spectrum that exhibits a peak maximum at 1515 cm?1; or (vii) an IR spectrum that exhibits band maxima at 1690 and 1515 cm?1;(2) the crystalline solid form is crystalline free form Form A characterized by (i) peaks in the XRPD spectrum comprising: 6.0, 18.3, 19.3, 20.2 and 22.0 °2?; (ii) peaks in the XRPD spectrum comprising: 6.0, 8.5, 9.5, 12.4-12.9, 13.4, 17.1, 18.3, 19.3, 20.2, 22.0, 30.1 and 34.1 °2?; (iii) peaks in the XRPD spectrum comprising: 6.0, 6.7, 8.5, 9.5, 10.9, 12.4-12.9, 13.4, 16.2, 17.1, 18.3, 19.3, 20.2, 22.0, 23.0, 24.1 to 24.8, 25.8, 30.1 and 34.1 °2?; (iv) an XRPD spectrum substantially similar to that shown in FIG. 2 or in FIG. 3A; (v) peaks in the XRPD spectrum comprising: 6.1 (80.81% rel int), 9.6 (40.35%), 12.6 (41.26%), 13.6 (43.19%), 18.4 (53.57%), 19.4 (100.00%), 20.3 (57.01%) and 22.0 (56.64) °2?; (vi) an XRPD spectrum substantially similar to that shown in FIG. 3C; (vii) a FT-Raman spectrum substantially similar to that shown in FIG. 10; or (viii) an IR spectrum that exhibits a band maximum at 1730 cm?1;(3) the crystalline solid form is crystalline free form Form D characterized by (i) peaks in the XRPD spectrum comprising: 17.1, 18.1, 18.8 and 25.0 °2?; (ii) peaks in the XRPD spectrum comprising: 8.8, 17.1, 18.1, 18.8, and 25.0 °2?; (iii) an XRPD spectrum substantially similar to that shown in FIG. 2 or FIG. 5A; (iv) peaks in the XRPD spectrum comprising: 4.7 (97.11% rel int), 8.3 (64.04%), 18.1 (80.97%), 18.6 (100.00%), and 26.8 (65.25) °2?; (v) an XRPD spectrum substantially similar to that shown in FIG. 5C; (vi) a FT-Raman spectrum substantially similar to that shown in FIG. 10; (vii) an IR spectrum that exhibits a band maximum at 1665 cm?1; (viii) an IR spectrum that exhibits a band maximum at 1639 cm?1; (ix) an IR spectrum that exhibits a band maximum at 968 cm?1; or (x) an IR spectrum that exhibits band maxima at 1665, 1639 and 968 cm?1;(4) the crystalline solid form is crystalline free form Form B characterized by (i) peaks in the XRPD spectrum comprising: 8.8, 16.4, 17.2, 18.8-19.1, 20.1, and 21.1-21.6°2?; (ii) peaks in the XRPD spectrum comprising: 8.8, 10.6, 12.6-13.0, 14.6, 16.4, 17.2, 18.8-19.1, 20.1, 21.1-21.6, 24.5, 25.3, 27.0-27.5, 28.9, 29.8 and 30.5°2?; (iii) an XRPD spectrum substantially similar to that shown in FIG. 2 or FIG. 4A; (iv) an XRPD spectrum substantially similar to that shown in FIG. 4C; (v) peaks in the XRPD spectrum comprising: 7.0 (44.44% rel int), 8.9 (76.55%), 17.4 (57.67%), 19.1 (100.00%), 20.3 (49.78%), 21.8 (36.16%), and 25.5 (52.26) °2?; (vi) a FT-Raman spectrum substantially similar to that shown in FIG. 10; or (vii) an IR spectrum that exhibits a peak maximum at 1200 cm?1;(5) the crystalline solid form is crystalline free form Form F characterized by peaks in the XRPD spectrum comprising: 5.3 (100.00% rel int), 8.6 (58.80%), 16.4 (62.95%), and 19.0 (48.51%) °2?; or an XRPD spectrum substantially similar to that shown in FIG. 7;(6) the crystalline solid form is crystalline free form Form G characterized by peaks in the XRPD spectrum comprising: 10.7 (55.47% rel int), 13.9 (42.47%), 18.33 (100.00% %), and 21.6 (40.73%) °2?; or an XRPD spectrum substantially similar to that shown in FIG. 8; or(7) the crystalline solid form is crystalline free form Form H characterized by (i) peaks in the XRPD spectrum comprising: 5.77 (89.22% rel int), 6.39 (100.00% %), 9.1 (84.17%), and 18.5 (67.04%) °2?; (ii) characterized by peaks in the XRPD spectrum comprising: 5.77 (89.22% rel int), 6.39 (100.00% %), 9.1 (84.17%), 18.5 (67.04%), and 18.83 (67.04%) °2?, or (iii) an XRPD spectrum substantially similar to that shown in FIG. 9.

US Pat. No. 10,889,576

PHTHALAZINONE COMPOUNDS AND METHODS FOR THE TREATMENT OF CYSTIC FIBROSIS

Flatley Discovery Lab, LL...

1. A compound of Formula IA:
or a pharmaceutically acceptable salt, ester or prodrug thereof;
wherein represents a double bond;
R1 is —C1-C8 alkoxy;
R2 is hydrogen;
R3 is methyl;
R4 is absent;
R5 is selected from C1-C8 alkyl and C3-C6-cycloalkyl;
R6 is halogen; and,
R7 is selected from hydrogen or halogen.

US Pat. No. 10,889,575

4,4-DIPHENYLPIPERIDINE COMPOUNDS OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, PHARMACEUTICAL COMPOSITIONS AND USES THEREOF

Academy of Military Medic...

1. A compound of Formula I or a pharmaceutically acceptable salt thereof:
wherein:
g is selected from the group consisting of methylene, carbonyl, methyleneacyl, ethylideneacyl, 1,3-propylideneacyl, 1,2-propylideneacyl, 1,4-butylideneacyl, 1,3-butylideneacyl and 1,2-butylideneacyl;
R is selected from the group consisting of substituted phenyl, thienyl and benzoxazolinonyl;
the substituted phenyl is substituted with one or more substituents, the substituent is selected from the group consisting of methoxy and dimethylamino.

US Pat. No. 10,889,574

METHOD FOR PRODUCING DIPHENYLMETHANE DERIVATIVE

DAEWOONG PHARMACEUTICAL C...

1. A method for producing a compound of the following Formula 1a, the method comprising the steps of:(1) reacting a compound of the following Formula 2 with a compound of the following Formula 3 and subjecting the resultant to a cyclization reaction, to obtain a compound of the following Formula 4;
(2) subjecting the compound of Formula 4 to aldehydation or amidation, followed by reacting the resultant with a compound of the following Formula 5 and performing reduction, to obtain a compound of the following Formula 6; and
(3) reacting the compound of Formula 6 with a compound of the following Formula 7, and performing deprotection and reduction,

in the formulae,
A is oxygen (O);
n is 1 or 2;
PG is a protecting group;
X? is halogen or C1-7 alkyl;
X, Y, and Hal are each independently halogen;
B is (B-1)

in which Ra, Rb, Rc, and Rd are each independently hydrogen, halogen, hydroxy, mercapto, cyano, nitro, amino, carboxy, oxo, C1-7 alkyl, C1-7 alkylthio, C2-7 alkenyl, C2-7 alkynyl, C1-7 alkoxy, C1-7 alkoxy-C1-7 alkyl, C2-7 alkenyl-C1-7 alkyloxy, C2-7 alkynyl-C1-7 alkyloxy, C3-10 cycloalkyl, C3-7 cycloalkylthio, C5-10 cycloalkenyl, C3-10 cycloalkyloxy, C3-10 cycloalkyloxy-C1-7 alkoxy, phenyl-C1-7 alkyl, C1-7 alkylthio-phenyl, phenyl-C1-7 alkoxy, mono- or di-C1-7 alkylamino, mono- or di-C1-7 alkylamino-C1-7 alkyl, C1-7 alkanoyl, C1-7 alkanoylamino, C1-7 alkylcarbonyl, C1-7 alkoxycarbonyl, carbarmoyl, mono- or di-C1-7 alkyl carbamoyl, C1-7 alkylsulfonylamino, phenylsulfonylamino, C1-7 alkylsulfinyl, C6-14 arylsulfanyl, C6-14 arylsulfonyl, C6-14 aryl, 5- to 13-membered heteroaryl, 5- to 10-membered heterocycloalkyl, 5- to 10-membered heterocycloalkyl-C1-7 alkyl, or 5- to 10-membered heterocycloalkyl-C1-7 alkoxy;
ring C is C3-10 cycloalkyl, C5-10 cycloalkenyl, C6-14 aryl, 5- to 13-membered heteroaryl, or 5- to 10-membered heterocycloalkyl;
the alkyl, alkenyl, alkynyl, and alkoxy are each independently unsubstituted, or have one or more substituents selected from the group consisting of halogen, hydroxy, cyano, nitro, amino, mercapto, C1-7 alkyl, and C2-7 alkynyl;
the cycloalkyl, cycloalkenyl, aryl, heteroaryl, and heterocycloalkyl are each independently unsubstituted, or have one or more substituents selected from the group consisting of halogen, hydroxy, cyano, nitro, amino, mercapto, C1-4 alkyl, and C1-4 alkoxy; and
the heteroaryl and heterocycloalkyl each independently contain one or more heteroatoms selected from the group consisting of N, S, and O.

US Pat. No. 10,889,573

ANTHELMINTIC QUINOLINE-3-CARBOXAMIDE DERIVATIVES

Bayer Animal Health GMBH,...

9. A pharmaceutical composition comprising a compound of formula (I) according to claim 1, or a stereoisomer, a tautomer, an N-oxide, a hydrate, a solvate, or a salt thereof, or a mixture of any of the foregoing, and one or more pharmaceutically acceptable excipients.

US Pat. No. 10,889,572

REACTIVE OXYGEN SPECIES SCAVENGERS AND USE FOR TREATING DISEASES

XW LABORATORIES INC., Gr...

1. A compound selected from:
or a pharmaceutically acceptable salt of any of the foregoing.

US Pat. No. 10,889,571

SUBSTITUTED BENZOIMIDAZOLES AND IMIDAZO[4,5-C]PYRIDINES FOR TREATING CERTAIN LEUKEMIAS

Terns, Inc., Foster City...

28. A compound selected from the group consisting of:or a pharmaceutically acceptable salt or tautomer thereof.

US Pat. No. 10,889,570

BENZAZEPINE DERIVATIVES

OTSUKA PHARMACEUTICAL CO....

1. A benzazepine compound of Formula (1):wherein R1 is C1-6 alkyl substituted with OH;L is a direct bond or —C(?O)—NH—;
Ring A1 is a hydrocarbon ring or heterocycle;
Ring A2 is a hydrocarbon ring or heterocycle; and
each of Rings A1 and A2 may have at least one substituent, or a salt thereof.

US Pat. No. 10,889,569

CONDENSED RING GROUP AZACYCLOBUTYL TRIAZOLE DERIVATIVE, PREPARATION METHOD THEREFOR AND USE THEREOF IN MEDICINE

Jiangsu Hengrui Medicine ...

1. A compound of formula (I):
or a tautomer, mesomer, racemate, enantiomer, diastereomer thereof, or a mixture thereof, or a pharmaceutically acceptable salt thereof,
wherein:
G is selected from the group consisting of C, CH and N;
ring A is aryl or heteroaryl;
ring B is selected from the group consisting of cycloalkyl, heterocyclyl, aryl and heteroaryl;
R1 is alkyl, wherein the alkyl is optionally substituted by one or more substituents selected from the group consisting of alkoxy, halogen, haloalkyl, haloalkoxy, hydroxy, hydroxyalkyl, cyano, amino, nitro, cycloalkyl, heterocyclyl, heterocyclyloxy, NHS(O)sR5, NHC(O)OR5, aryl and heteroaryl;
each R2 is identical or different and each is independently selected from the group consisting of hydrogen, halogen, alkyl, alkoxy, haloalkyl, oxo, hydroxy, hydroxyalkyl, cyano, amino, nitro, cycloalkyl, heterocyclyl and —C(O)OR5;
each R3 is identical or different and each is independently selected from the group consisting of hydrogen, halogen, alkyl, alkoxy, haloalkyl, hydroxy, hydroxyalkyl, cyano, amino, nitro, cycloalkyl and heterocyclyl;
each R4 is identical or different and each is independently selected from the group consisting of hydrogen, halogen, alkyl, alkoxy, haloalkyl, oxo, hydroxy, hydroxyalkyl, cyano, amino, nitro, cycloalkyl, heterocyclyl and —C(O)OR5;
R5 is selected from the group consisting of hydrogen, alkyl, haloalkyl, hydroxyalkyl, cycloalkyl, heterocyclyl, aryl and heteroaryl;
s is 0, 1 or 2;
n is 0, 1, 2, 3 or 4;
m is 0, 1, 2, 3 or 4; and
t is 0, 1, 2 or 3.

US Pat. No. 10,889,567

PYRIDIN-2(1H)-ONE QUINOLINONE DERIVATIVES AS MUTANT-ISOCITRATE DEHYDROGENASE INHIBITORS

FORMA Therapeutics, Inc.,...

1. A method of preparing Compound I-13:
wherein the method comprises steps of:
reacting Intermediate II-1 or a salt thereof and Intermediate III-1:

to provide Compound I-13; and
preparing Intermediate II-1 or a salt thereof by contacting ((S)—N—((S)-1-(6-chloro-2-oxo-1,2-dihydroquinolin-3-yl)ethyl)-2-methyl propane-2-sulfinamide:

with a suitable acid to provide Intermediate II-1 or a salt thereof.

US Pat. No. 10,889,566

DERIVATIVES AND COMPOSITION OF QUINOLINE AND NAPHTHYRIDINE

Chulabhorn Foundation, B...

1. A compound of the formula (I):
where
X and Y may be identical or different and represent O, NH, or S;
R1, R2, R3, R4, R5, R6, R7, R8, R9, and R10 may be identical or different and represent H, halogen, CN, NO2, (C1-4)alkyl, (C1-4)haloalkyl, (C2-4)alkenyl, OH, O(C1-4)alkyl, O(C1-4)haloalkyl, N(RA)RB, C(O)N(RA)RB, C(O)RA, CO2RA, CHO, C2-4 alkenyl substituted with CN, C2-4 alkenyl substituted with COOH, C2-4 alkenyl substituted with CHO, or C2-4 alkenyl substituted with OH;
RA and RB may be identical or different and represent H, (C1-4)alkyl, (C1-4)haloalkyl, or (C2-4)alkenyl;
A1, A2, A3, and A4 may be identical or different and represent CH or N with the proviso that either A1 or A2 is N, A1 and A2 cannot both be N, and R5 and R10 are absent when A3 and A4 are N;
or a pharmaceutically acceptable salt thereof, stereoisomer thereof, or mixture comprising stereoisomers thereof.

US Pat. No. 10,889,565

4-HYDROXY-3-SULFONYLPYRIDIN-2(1H)-ONES AS APJ RECEPTOR AGONISTS

Bristol-Myers Squibb Comp...

1. A compound of Formula (V):
or a pharmaceutically acceptable salt thereof, wherein
ring A is independently selected from 5- or 6-membered aryl and heteroaryl comprising carbon atoms and 1-4 heteroatoms selected from N, NR3a, O, and S, each substituted with 1-3 R3 and 1-2 R5; provided R3 and R5 are not both H;
ring B is a 6-membered aryl substituted with 1-3 R1;
R1 is —OC1-4 alkyl;
R2 is independently selected from C1-5 alkyl substituted with 0-3 Re; and aryl substituted with 0-3 Re; provided when R2 is C1-5 alkyl, the carbon atom except the one attached to the pyridine ring may be replaced by O, N, and S;
R3 is independently selected from H, F, Cl, Br, C1-5 alkyl substituted with 0-3 Re, C2-5 alkenyl substituted with 0-3 Re, —(CH2)nORb, —(CH2)nNRaRa, —(CH2)nNHC(?O)Rb, —(CH2)nNHC(?O)NRaRa, and —(CH2)nNHC(?O)ORb;
R3a is H;
R5 is independently selected from H, R6, and —NRaC(?O)R6;
R6 is independently selected from —(CR7R7)n-aryl, —(CR7R7)n—C3-6 cycloalkyl, and —(CR7R7)n-heteroaryl, each substituted with 1-6 R8;
R7 is independently selected from H, and C1-4 alkyl;
R8 is independently selected from H, F, Cl, Br, —(CH2)nORb, —(CH2)nC(?O)NRaRa, C1-4 alkyl substituted with 0-3 Re, (CH2)n—C3-6 carbocyclyl substituted with 0-3 Re and —(CH2)n-heterocyclyl substituted with 0-3 Re;
Ra is independently selected from H, —(CH2)n—C3-10carbocyclyl substituted with 0-5 Re, and —(CH2)n-heterocyclyl substituted with 0-5 Re;
Rb is independently selected from H, C1-6 alkyl substituted with 0-5 Re, and —(CH2)n-heterocyclyl substituted with 0-5 Re;
Re is independently selected from C1-6 alkyl substituted with 0-5 Rf, F, Cl, Br, ?O, and —(CH2)nORf;
Rf is independently selected from H, F, Cl, Br, and C1-5alkyl (optionally substituted with F, Cl, Br and OH); and
n is independently selected from zero, 1, 2, 3, and 4.

US Pat. No. 10,889,564

TETRAHYDROINDAZOLES AND MEDICAL USES THEREOF

Genase Therapeutics B.V.,...

1. A compound of formula Ia
or a pharmaceutically acceptable salt thereof, wherein:
A1 represents aryl optionally substituted by one or more groups independently selected from G1 or heteroaryl optionally substituted by one or more groups independently selected from G2;
A2 represents aryl optionally substituted by one or more groups independently selected from G3 or heteroaryl optionally substituted by one or more groups independently selected from G4;
L1 represents —C(O)—, —C(O)N(R3)—, —C(O)O—, —S(O)j— or —S(O)kN(R4)—;
R1 represents H or C1-3 alkyl optionally substituted by one or more halo;
R2 represents F;
R3 and R4 each independently represents H or C1-3 alkyl optionally substituted by one or more halo;
each G1 independently represents halo, Ra1, —CN, -Aa1-C(Qa1)Rb1, -Ab1-C(Qb1)N(Rc1)Rd1, -Ac1-C(Qc1)ORc1, -Ad1-S(O)pRf1, -Ae1-S(O)qN(Rg1)Rh1, -Af1-S(O)pORi1, —N3, —N(Rj1)Rk1, —N(H)CN, —NO2, —ONO2, —ORl1 or —SRm1;
each Qa1 to Qc1 independently represents ?O, ?S, ?NRn1 or ?N(ORo1);
each Aa1 to Af1 independently represents a single bond, —N(Rp1)— or —O—;
each G2 independently represents halo, Ra2, —CN, -Aa2-C(Qa2)Rb2-Ab2-C(Qb2)N(Rc2)Rd2, -Ac2-C(Qc2)ORc2, -Ad2-S(O)pRf2, -Ae2-S(O)qN(Rg2)Rh2, -Af2-S(O)pORi2, —N3, —N(Rj2)Rk2, —N(H)CN, —NO2, —ONO2, —ORl2 or —SRm2;
each Qa2 to Qc2 independently represents ?O, ?S, ?NRn2 or ?N(ORo2);
each Aa2 to Af2 independently represents a single bond, —N(Rp2)— or —O—;
each G3 independently represents halo, Ra3, —CN, -Aa3-C(Qa3)Rb3, -Ab3-C(Qb3)N(Rc3)Rd3, -Ac3-C(Qc3)ORe3, -Ad3-S(O)pRf3, -Ae3-S(O)qN(Rg3)Rh3, -Af3-S(O)pORi3, —N3, —N(Rj3)Rk3, —N(H)CN, —NO2, —ONO2, —ORl3 or —SRm3;
each Qa3 to Qc3 independently represents ?O, ?S, ?NRn3 or ?N(ORo3);
each Aa3 to Af3 independently represents a single bond, —N(Rp3)— or —O—;
each G4 independently represents halo, Ra4, —CN, -Aa4-C(Qa4)Rb4, -Ab4-C(Qb4)N(Rc4)Rd4, -Ac4-C(Qc4)ORe4, -Ad4-S(O)pRf4, -Ae4-S(O)qN(Rg4)Rh4, -Af4-S(O)pORi4, —N3, —N(Rj4)Rk4, —N(H)CN, —NO2, —ONO2, —ORl4 or —SRm4;
each Qa4 to Qc4 independently represents ?O, ?S, ?NRn4 or ?N(ORo4);
each Aa4 to Af4 independently represents a single bond, —N(Rp4)— or —O—;
each Ra1 and Rf1 independently represents C1-6 alkyl optionally substituted by one or more groups independently selected from G5a, heterocycloalkyl optionally substituted by one or more groups independently selected from G5b, aryl optionally substituted by one or more groups independently selected from G5c, or heteroaryl optionally substituted by one or more groups independently selected from G5d;
each Rp1 independently represents H or C1-6 alkyl optionally substituted by one or more halo;
each Rb1, Rc1, Rd1, Re1, Rg1, Rh1, Ri1, Rj1, Rk1, Rl1, Rm1, Rn1 and Ro1 independently represents H, C1-6 alkyl optionally substituted by one or more groups independently selected from G5a, heterocycloalkyl optionally substituted by one or more groups independently selected from G5b, aryl optionally substituted by one or more groups independently selected from G5c, or heteroaryl optionally substituted by one or more groups independently selected from G5d; or
alternatively any of Rc1 and Rd1, Rg1 and Rh1 and/or Rj1 and Rk1 are linked together to form, together with the nitrogen atom to which they are attached, a 3- to 6-membered ring, which ring optionally contains one further heteroatom and which ring optionally is substituted by one or more groups independently selected from halo, C1-3 alkyl optionally substituted by one or more halo, and ?O;
each Ra2 and Rf2 independently represents C1-6 alkyl optionally substituted by one or more groups independently selected from G6a, heterocycloalkyl optionally substituted by one or more groups independently selected from G6b, aryl optionally substituted by one or more groups independently selected from G6c, or heteroaryl optionally substituted by one or more groups independently selected from G6d;
each Rp2 independently represents H or C1-6 alkyl optionally substituted by one or more F;
each Rb2, Rc2, Rd2, Re2, Rg2, Rh2, Ri2, Rj2, Rk2, Rl2, Rm2, Rn2 and Ro2 independently represents H, C1-6alkyl optionally substituted by one or more groups independently selected from G6a, heterocycloalkyl optionally substituted by one or more groups independently selected from G6b, aryl optionally substituted by one or more groups independently selected from G6c, or heteroaryl optionally substituted by one or more groups independently selected from G6d; or
alternatively any of Rc2 and Rd2, Rg2 and Rh2 and/or Rj2 and Rk2 are linked together to form, together with the nitrogen atom to which they are attached, a 3- to 6-membered ring, which ring optionally contains one further heteroatom and which ring optionally is substituted by one or more groups independently selected from halo, C1-3 alkyl optionally substituted by one or more halo, and ?O;
each Ra3 and Rf3 independently represents C1-6 alkyl optionally substituted by one or more groups independently selected from G7a, heterocycloalkyl optionally substituted by one or more groups independently selected from G7b, aryl optionally substituted by one or more groups independently selected from G7c, or heteroaryl optionally substituted by one or more groups independently selected from G7d;
each Rp3 independently represents H or C1-6 alkyl optionally substituted by one or more F;
each Rb3, Rc3, Rd3, Re3, Rg3, Rh3, Ri3, Rj3, Rk3, Rl3, Rm3, Rn3 and Ro3 independently represents H, C1-6 alkyl optionally substituted by one or more groups independently selected from G7a, heterocycloalkyl optionally substituted by one or more groups independently selected from G7b, aryl optionally substituted by one or more groups independently selected from G7c, or heteroaryl optionally substituted by one or more groups independently selected from G7d; or
alternatively any of Rc3 and Rd3, Rg3 and Rh3 and/or Rj3 and Rk3 are linked together to form, together with the nitrogen atom to which they are attached, a 3- to 6-membered ring, which ring optionally contains one further heteroatom and which ring optionally is substituted by one or more groups independently selected from halo, C1-3 alkyl optionally substituted by one or more halo, and ?O;
each Ra4 and Rf4 independently represents C1-6 alkyl optionally substituted by one or more groups independently selected from G8a, or heterocycloalkyl optionally substituted by one or more groups independently selected from G8b, aryl optionally substituted by one or more groups independently selected from G8c, or heteroaryl optionally substituted by one or more groups independently selected from G8d;
each Rp4 independently represents H or C1-6 alkyl optionally substituted by one or more F;
each Rb4, Rc4, Rd4, Re4, Rg4, Rh4, Ri4, Rj4, Rk4, Rl4, Rm4, Rn4 and Ro4 independently represents H, C1-6alkyl optionally substituted by one or more groups independently selected from G8a or heterocycloalkyl optionally substituted by one or more groups independently selected from G8b; or
alternatively any of Rc4 and Rd4, Rg4 and Rh4 and/or Rj4 and Rk4 are linked together to form, together with the nitrogen atom to which they are attached, a 3- to 6-membered ring, which ring optionally contains one further heteroatom and which ring optionally is substituted by one or more groups independently selected from halo, C1-3 alkyl optionally substituted by one or more halo, and ?O;
each G5a, G5b, G6a, G6b, G7a, G7b, G8a and G8b independently represents halo, —CN, —N(Rb5)Rc5, —ORd5, —SRe5 or ?O;
each G5c, G5d, G6c, G6d, G7c, G7d, G8c and G8d independently represents halo, Ra5, —CN, —N(Rb5)Rc5, —ORd5, —SRe5 or ?O;
each Ra5 independently represents C1-6 alkyl optionally substituted by one or more F;
each Rb5, Rc5, Rd5 and Re5 independently represents H or C1-6 alkyl optionally substituted by one or more F;
or Rb5 and Rc5 are linked together to form, along with the nitrogen atom to which they are attached, a 3- to 6-membered ring, which ring optionally contains one further heteroatom and which ring optionally is substituted by one or more groups independently selected from F, C1-3 alkyl optionally substituted by one or more F, and ?O;
each j independently represents 0, 1 or 2;
each k, p and q independently represents 1 or 2; and
n represents 0 to 7;
with the proviso that the compound of formula Ia is not (R)—N-(1-(2,4-difluorophenyl)-4,5,6,7-tetrahydro-1H-indazol-4-yl)picolinamide.

US Pat. No. 10,889,563

DEOXYURIDINE TRIPHOSPHATASE INHIBITORS

UNIVERSITY OF SOUTHERN CA...

1. A compound of formula (I):
or a tautomer thereof, including any stereoisomer, enantiomer or diastereoisomer,
or a pharmaceutically acceptable salt of each thereof, wherein

R11 is hydrogen, halo, R12 or —O-R12;
R12 is C1-C6 alkyl, C2-C6 alkenyl, or C2-C6 alkynyl optionally substituted with 1-3 hydroxy, fluoro, chloro, and amino substituent;
r is 1, 2, or 3;
W is a bond or optionally substituted —CH2—;
X is a bond, O, S, NR19, optionally substituted C1-C6 alkylene, optionally substituted C2-C6 alkenylene, or optionally substituted C2-C6 alkynylene group, a divalent optionally substituted C6-C10 aromatic hydrocarbon group, or a divalent optionally substituted saturated or unsaturated C2-C10 heterocyclic or optionally substituted C1-C10 heteroaryl group;
R19 is hydrogen, optionally substituted C1-C6 alkyl or optionally substituted C3-C8 cycloalkyl;
Y is a bond or a linear or branched optionally substituted C1-C10 alkylene which further optionally has a cycloalkylidene structure on one carbon atom, or is optionally substituted C2-C6 alkenylene, or optionally substituted C2-C6 alkynylene group;
Z is —PO2—NR31R32, —SO2NR31R32, —NR3PO2—R4, or —NR3SO2—R4, wherein R31 and R32 are the same or different and each represents a hydrogen atom, optionally substituted C1-C6 alkyl group optionally substituted with an optionally substituted aryl group, wherein the aryl group, together with the R31 or R32, may form a condensed bicyclic hydrocarbon, or R31 and R32 taken together with the adjacent nitrogen atom form an optionally substituted C2-C10 heterocyclic group;
R3 is hydrogen or optionally substituted C1-C6 alkyl; and
R4 is optionally substituted C6-C10 aryl or an optionally substituted C2-C10 heterocyclic group; or
-W-X-Y-Z is -W-X-Y-Z?, wherein
-W-X-Y- is
—CH2- X-SO2—NH—CH(RY)—, —CH2-X-SO2—NH—C(RY)2—, or —CH2-X-B-CH2CRZRW-,
X is optionally substituted C1-C6 alkylene wherein one of the methylene groups within the alkylene chain is optionally replaced with an O or S atom, such that X is optionally substituted alkylene or a heteroalkylene,
B is an optionally substituted C3-C10 heteroaryl, RY and RW are independently hydrogen or optionally substituted C1-C6 alkyl; and
RZ is hydrogen or hydroxy; or
-W-X-Y- is

wherein
X10 is NH, NCO2R20, O, or CH2,
R20 is C1-C6 alkyl optionally substituted with 1-3 C6-C10 aryl groups,
u is 0, 1, 2, 3, or 4,
Y1 is CH2, O or S,
RZ is hydroxy or hydrogen,
RW is C1-C6 alkyl or hydrogen, and
Z? is

wherein
R6 is hydrogen, optionally substituted C1-C6 alkoxy, or halo, and
R7 is optionally substituted C1-C6 alkyl, optionally substituted C2-C6alkenyl, optionally substituted C2-C6 alkynyl, optionally substituted C3-C8cycloalkyl, optionally substituted C3-C10 heteroaryl, optionally substituted C3-C10heterocyclyl, or optionally substituted phenyl; or
Z? is a phenyl substituted with an R6 and an R60 groups, wherein
the R6 and the R60 groups are positioned 1, 2 with respect to each other,
R60 is —OR7 or —NHR7R70,
R7 is optionally substituted C1-C6 alkyl, optionally substituted C2-C6 alkenyl, optionally substituted C2-C6 alkynyl, optionally substituted C3-C8 cycloalkyl, optionally substituted C3-C10 heteroaryl, optionally substituted C3-C10 heterocyclyl, or optionally substituted phenyl, and
R70 is hydrogen or R7;
provided that when W is a bond, Y is a bond, Z is —SO2NR31R32, and one of R31 or R32 is H and the other is a C1-C2 alkyl substituted with a phenyl, then X is not C2 alkylene;
provided that when W is CH2, Y is a bond, Z is —SO2NR31R32, and one of R31 or R32 is H and the other is a C1 alkyl substituted with a single phenyl that is substituted with a single halo substituted phenoxy, then X is not a divalent aromatic hydrocarbon group mono-substituted with a methoxy group; and
provided that when X is a divalent optionally substituted C6-C10 aromatic hydrocarbon group, then W and Y cannot both be a bond.

US Pat. No. 10,889,562

PRODRUGS OF NRF2 ACTIVATING COMPOUNDS AND USES THEREOF

Rigel Pharmaceuticals, In...

1. A method of treating a disease of disorder in a subject in need thereof, the method comprising:administering to the subject a pharmaceutically effective amount of a compound of formula (I):

wherein:
R2 is selected from the group consisting of sulfonyl, carboxyl, carboxyl ester, and aminoacyl;
R3 is selected from the group consisting of an active agent, an antioxidant, an amino acid, an amino acid derivative, a peptide, and a peptide derivative;
R4 is selected from the group consisting of hydrogen, alkyl, substituted alkyl, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, cycloalkyl, substituted cycloalkyl, heterocyclyl, substituted heterocyclyl, aryl, substituted aryl, heteroaryl, and substituted heteroaryl;
X1 and X2 are each independently selected from N and CH, wherein at least one of X1 and X2 is N; and
n is an integer from 1 to 6,
or a salt or a stereoisomer thereof,
wherein the administering is sufficient to treat the disease or disorder, and wherein the disease or disorder is selected from the group consisting of cardiac insufficiency, asthma, arthritis, an inflammatory bowel disease, and a chronic obstructive pulmonary disease.

US Pat. No. 10,889,560

4-AMINO-2-PYRIDO-BICYCLIC PYRIMIDINES AND USE THEREOF AS TOPOISOMERASE II INHIBITORS

FONDAZIONE ISTITUTO ITALI...

1. A compound of Formula (Ia)
wherein R?H, C1-6 alkyl, C1-6 alkoxy, OH, NR?R?? and
R??H, C1-6 alkyl;
R? and R?? are, independently, H, C1-6 alkyl, C1-C6 alkylalkoxy or together may form a 4 to 7-membered heterocyclic ring with the nitrogen atom to which they are connected.

US Pat. No. 10,889,558

AMBER ODORANT

Firmenich SA, Satigny (C...

1. A compound of formulain the form of any one of its stereoisomers or a mixture thereof, and wherein the Q group represents a —CH?CH—CH3 group or a —C?C—CH3 group.

US Pat. No. 10,889,557

METHOD OF PRODUCING AN ALKOXYFLAVONE DERIVATIVE

TOKIWA PHYTOCHEMICAL CO.,...

1. A method of producing alkoxyflavone derivatives, comprising a step of reacting hydroxyflavone derivatives represented by the following Chemical Formula (1) and dialkyl sulfate in the presence of dimethyl sulfoxide and an alkali hydroxide,
wherein R11-R14, R21-R25, and R3 are each independently hydrogen, hydroxyl group, ester group, alkoxy group, alkylenedioxy group, sulfonyl group and alkyl group, and at least two of R11-R14, R21-R25, and R3 are hydroxyl groups.

US Pat. No. 10,889,556

COMPOSITIONS AND METHODS FOR INHIBITING INFLUENZA RNA POLYMERASE PA ENDONUCLEASE

The Regents of the Univer...

1. A compound having the formula:
wherein,
Y is O, S, or NH;
W1 is —CH(R1)—, or —N(R1)—;
R1 is hydrogen;
W2 is —C(R2)?;
R2 is hydrogen, halogen, —CX23, —CHX22, —CH2X2, —OCX23, —OCH2X2, —OCHX22, —CN, —SOn2R2D, —SOv2NR2AR2B, —NHC(O)NR2AR2B, —N(O)m2, —NR2AR2B, —C(O)R2C, —C(O)—OR2C, —C(O)NR2AR2B, —OR2D, —NR2ASO2R2D, —NR2AC(O)R2C, —NR2AC(O)OR2C, —NR2AOR2C, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
R3 is substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
R4 is halogen, —CX43, —CHX42, —CH2X4, —OCX43, —OCH2X4, —OCHX42, —CN, —SOn4R4D, —SOv4NR4AR4B, —NHC(O)NR4AR4B, —N(O)m4, —NR4AR4B, —C(O)R4C, —C(O)—OR4C, —C(O)NR4AR4B, —OR4D, —NR4ASO2R4D, —NR4AC(O)R4C, —NR4AC(O)OR4C, —NR4AOR4C, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
each R2A, R2B, R2C, R2D, R4A, R4B, and R4D are independently hydrogen, —CX3, —CN, —COOH, —CONH2, —CHX2, —CH2X, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl; R2A and R2B substituents bonded to the same nitrogen atom may optionally be joined to form a substituted or unsubstituted heterocycloalkyl or substituted or unsubstituted heteroaryl; R4A and R4B substituents bonded to the same nitrogen atom may optionally be joined to form a substituted or unsubstituted heterocycloalkyl or substituted or unsubstituted heteroaryl;
R1D is hydrogen;
R4C is hydrogen;
each X, X2, and X4 is independently —F, —Cl, —Br, or —I;
n2 and n4 are independently an integer from 0 to 4; and
m2, m4, v2 and v4 are independently an integer from 1 to 2.

US Pat. No. 10,889,555

SULFONAMIDE COMPOUND OR SALT THEREOF

Taiho Pharmaceutical Co.,...

1. A compound represented by the following formula (I):
wherein X1 represents an oxygen atom or a sulfur atom;
X2 and X3 represent oxygen atoms; X2 represents an oxygen atom, and X3 represents —NH—; or X2 represents —NH—, and X3 represents an oxygen atom;
X4 represents a hydrogen atom or a C1-C6 alkyl group;
R1 represents —C(R11)(R12)— or —C(?CH2)—;
R11 and R12 are the same or different and represent a hydrogen atom, a halogen atom, or a hydroxy group, or a C1-C6 alkyl group, alternatively may be taken together with the carbon atoms to which R11 and R12 are attached to form a saturated hydrocarbon ring having 3 to 8 carbon atoms;
R2 represents a C6-C14 aromatic hydrocarbon group or a 9 or 10 membered fully unsaturated heterocyclic group,
wherein R2 may have substituents, and when R2 has two substituents on carbon atoms which are adjacent to each other on the aromatic hydrocarbon ring, the substituents may be fused together with carbon atoms to which the substituents bind to form a saturated or partially unsaturated 4-8 membered hydrocarbon ring or heterocyclic ring, either of which may have substituents,
R3 represents a C6-C14 aromatic hydrocarbon group or a 5-10 membered fully unsaturated heterocyclic group,
wherein R3 may have substituents, and when R3 has two substituents on the carbon atoms which are adjacent to each other on the aromatic hydrocarbon ring, the substituents may be fused together with carbon atoms to which the substituents bind to form a saturated or partially unsaturated 4-8 membered hydrocarbon ring or heterocyclic ring, either of which may have substituents; and
R4 represents a hydrogen atom or a C1-C6 alkyl group;
with the proviso that X1 is an oxygen atom when X2 represents an oxygen atom, X3 represents —NH—, X4 represents a hydrogen atom, R1 represents —CH2—, R2 represents a phenyl group, R3 represents 4-methylphenyl group, and R4 represents a hydrogen atom,
or a salt thereof.

US Pat. No. 10,889,554

EXCIMER FORMING COMPOUNDS

The Governing Council of ...

1. A method of detecting RNA or proximally phosphorylated polypeptides, comprising:(a) contacting a sample with an excimer forming compound of the Formula I
W—V?Y]n  (I)wherein,W is an excimer forming fluorophore;
V is a linker moiety, wherein the linker moiety is C1-10-alkylene;
Y is a metal ion coordinating moiety having the structure
andn is 1, 2 or 3; and
a suitable metal ion;
(b) detecting a fluorescence signal at a wavelength specific for the excimer forming fluorophore of the compound;
(c) comparing the fluorescence signal of (b) with the fluorescence intensity of a control sample;
wherein detection of a signal in the sample having a fluorescence intensity greater than the control sample indicates that the sample contains RNA or a proximally phosphorylated polypeptide.

US Pat. No. 10,889,553

ASYMMETRIC TRIAZOLE BENZAMIDE DERIVATIVES AND THE COMPOSITIONS AND METHODS OF TREATMENT REGARDING THE SAME

NysnoBio Ireland DAC, Du...

1. A compound of formula (I):
or a pharmaceutically acceptable salt thereof, wherein:
L1, L2 and L3 are each independently selected from a bond, alkylene, or alkenylene;
M1 and M2 are each independently selected from —NR4—, —NR4C(O)—, —N(C(O)R1)—, —C(O)NR4—, —NR4C(O)NR4—, —C(O)—, —C(?NR4)—, —C(?NOR4)—, —OC(O)—, —C(O)O—, —OC(O)O—, —OC(O)NR4—, —NR4C(O)O—, —S(O)m—, —S(O)mNR4—, or —NR4S(O)m—, provided that M1 and M2 are not both —NR4—;
R1 and R2 are each independently selected from an alkyl, alkenyl, cycloalkyl, aryl, biphenyl, heterocyclyl heterocycloalkyl, heteroaryl, cycloalkylalkyl, arylalkyl, arylalkenyl, arylalkynyl, heterocyclylalkyl, heteroarylalkyl, heteroarylalkenyl, or heteroarylalkynyl, wherein each cycloalkyl, aryl, heteroaryl, and heterocyclyl portion is optionally substituted with one or more R5;
R3 is selected from an alkyl, alkenyl, cycloalkyl, aryl, biphenyl, heterocyclyl heterocycloalkyl, heteroaryl, cycloalkylalkyl, arylalkyl, arylalkenyl, arylalkynyl, heterocyclylalkyl, heteroarylalkyl, heteroarylalkenyl, or heteroarylalkynyl, wherein each cycloalkyl, aryl, heteroaryl, and heterocyclyl portion is optionally substituted with one or more R7;
R4 is each independently H, or alkyl, wherein each alkyl is optionally substituted with one or more R5;
R5 is each independently I, Br, Cl, F, —CH2F, —CHF2, —CF3, —OCF3, —CN, -alkyl-CN, —CONH2, —CONHR6, —CONR6R6, —COOH, —NH2, —NHR6, —NO2, —NR6R6, —N3, —OH, OR6, —COOR6, —OSO3R6, oxo, R6, —SH, —SO2R6, —SO3H, —SO3R6, or —SR6;
R6 is each independently alkyl, alkenyl, alkynyl, haloalkyl, haloalkenyl, haloalkynyl; or alternatively two R6 on the same N atom can together form a 3-6 membered N-heterocyclyl;
R7 is each independently I, Br, Cl, F, —CH2F, —CHF2, —CF3, —OCF3, —CN, -alkyl-CN, —CONH2, —CONHR6, —CONR6R6, —COOH, —NH2, —NHR6, —NO2, —NR6R6, —N3, —OH, OR6, —COOR6, —OSO3R6, oxo, R6, —SH, —SO2R6, —SO3H, —SO3R6, —SR6, cycloalkyl, heterocyclyl, aryl, or heteroaryl, wherein each cycloalkyl, heterocyclyl, aryl, and heteroaryl is optionally substituted with one or more R5;
m is 0, 1, or 2; and
wherein the compound is not N,N?-(1-phenyl-1H-1,2,4-triazole-3,5-diyl)dibenzamide, N-(3-benzamido-1-phenyl-1H-1,2,4-triazol-5-yl)furan-2-carboxamide, N-(5-cinnamamido-1-phenyl-1H-1,2,4-triazol-3-yl)benzamide, N-(1-phenyl-5-(phenylamino)-1H-1,2,4-triazol-3-yl)benzamide, 4-fluoro-N-(5-(4-methoxybenzamido)-1-phenyl-1H-1,2,4-triazol-3-yl)benzamide, N,N?-(1-phenyl-1H-1,2,4-triazole-3,5-diyl)bis(4-methylbenzamide), N-(5-((2-chlorobenzyl)amino)-1-phenyl-1H-1,2,4-triazol-3-yl)-2-fluorobenzamide, N-(3-benzamido-1-phenyl-1H-1,2,4-triazol-5-yl)-4-fluorobenzamide, N-(3-benzamido-1-phenyl-1H-1,2,4-triazol-5-yl)-4-nitrobenzamide, N-(3-benzamido-1-phenyl-1H-1,2,4-triazol-5-yl)-3-nitrobenzamide, or 4-((3-benzamido-1-phenyl-1H-1,2,4-triazol-5-yl)carbamoyl)benzoic acid.

US Pat. No. 10,889,552

DIHYDROXYBENZAMIDE COMPOUND HAVING HSP90 INHIBITORY ACTIVITY OR PHARMACEUTICALLY ACCEPTABLE SALT THEREOF, AND MEDICAL USE THEREOF

ONCOZEN CO.. LTD., Seoul...

1. A compound of Chemical Formula 2 or a pharmaceutically acceptable salt thereof:
wherein R1 is isopropyl, and
R2 is

R3 is methyl, and
R9 is methyl, ethyl, or propyl.

US Pat. No. 10,889,551

BIEMAMIDES AND RELATED SCAFFOLDS AS INHIBITORS OF TRANSFORMING GROWTH FACTOR-BETA SIGNALING

Wisconsin Alumni Research...

1. A method of treatment comprising administering to a mammal suffering from a disease or disorder mediated by TGF-? signaling, an effective amount of a compound of Formula I, a stereoisomer, tautomer, and/or pharmaceutically acceptable salt thereof or a pharmaceutical composition comprising the effective amount of the compound of Formula I, stereoisomer, tautomer, and/or pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, wherein the compound of Formula I has the structureand wherein:R1 is a C12-C18 alkyl or alkenyl;
R2 is a C1-C6 alkyl; and
n is 1, 2, 3, 4, 5, or 6.

US Pat. No. 10,889,550

CONTRAST AGENTS FOR MYOCARDIAL PERFUSION IMAGING

Lantheus Medical Imaging,...

1. A contrast agent comprising an imaging moiety, and a fenazaquin analog having the structure of formula (II),
wherein:
G is
wherein:R30, R31, R32, and R3 are independently selected from hydrogen, C1-C6 alkyl optionally substituted with an imaging moiety, and an imaging moiety;
R34 is selected from hydrogen and an imaging moiety;
J is selected from N(R27), S, O, C(?O), C(?O)O, NHCH2CH2O, a bond, and C(?O)N(R27), with each group being drawn with its left end attached to G and its right end attached to the carbon substituted with R21 and R22;
wherein R27 is selected from hydrogen, C1-C6 alkyl optionally substituted with an imaging moiety, and an imaging moiety;
when present, K is selected from hydrogen, alkoxyalkyl, alkyloxy, aryl, C1-C6 alkyl optionally substituted with an imaging moiety, heteroaryl, and an imaging moiety;
when present, L is selected from hydrogen, alkoxyalkyl, alkyloxy, aryl, C1-C6 alkyl optionally substituted with an imaging moiety, heteroaryl, and an imaging moiety;
M is selected from hydrogen, alkoxyalkyl, alkyloxy, aryl, C1-C6 alkyl optionally substituted with an imaging moiety, heteroaryl, and an imaging moiety; or
L and M, together with the atom to which they are attached, form a three- or four-membered carbocyclic ring;
n is 0, 1, 2, or 3;
Y is selected from a bond, carbon, and oxygen; provided that when Y is a bond, K and L are absent and M is selected from aryl and heteroaryl; and provided that when Y is oxygen, K and L are absent and M is selected from hydrogen, alkoxyalkyl, aryl, C1-C6 alkyl optionally substituted with an imaging moiety, and heteroaryl;
provided that at least one imaging moiety is present in formula (II),
wherein the imaging moiety is 11C, 13N, 18F, 123I, 125I, 99mTc, 95Tc, 111In, 62Cu, 64Cu, 67Ga, or 68Ga.

US Pat. No. 10,889,549

CONTINUOUS PROCESS FOR THE PREPARATION OF 2-(1H-IMIDAZOL-4-YL) ETHANAMINE AND PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF

Jubilant Generics Limited...

1. A process for the preparation of histamine or pharmaceutically acceptable salts thereof, comprising(a) preparing a solution of L-histidine of Formula II and a catalyst in a solvent;

(b) performing a decarboxylation reaction by feeding the solution of step (a) to a continuous reactor to obtain histamine; and
optionally converting histamine to its pharmaceutically acceptable salts.

US Pat. No. 10,889,548

COMPOSITIONS AND METHODS FOR INHIBITING DIHYDROOROTATE DEHYDROGENASE

Clear Creek Bio, Inc., C...

1. A method of making a 2-(2?-halo-1-1?-biphenyl-4-yl)-quinoline carboxylic acid, the method comprising:incubating a compound of formula (I) with a compound of formula (II) in a mixture comprising a base at a temperature of from 60° C. to 70° C. for from 15 hours to 30 hours; and
adding an acid, to the mixture, thereby creating a compound of formula (III) according to following reaction:

wherein:
R1, R2, R3, and R4 are independently H, F, Cl, Br, I, CH3, CF3, SCH3 or CH2 CH3, at least two of R1, R2, R3, and R4 being H;
R5 is H, alkoxy of 1-3 carbon atoms, or alkyl of 1-2 carbon atoms;
R6 and R7 are independently H, F, Cl, Br, alkyl of 1-5 carbon atoms, NO2, OH, CF3 or OCH3;
X is a halogen.

US Pat. No. 10,889,547

METHOD FOR THE PURIFICATION OF ETHOXYQUIN

BASF SE, Ludwigshafen am...

1. A process for purifying ethoxyquin comprising p-phenetidine, comprising at least one step of continuous distillation using at least one dividing wall column, wherein ethoxyquin is obtained comprising less than 100 ppm p-phenetidine, whereinA) the at least one dividing wall column has a number of separation stages of 10 to 100;
B) the at least one dividing wall column is operated at 1 to 100 mbar;
C) the bottom temperature of the at least one dividing wall column is set to values of 80 to 200° C.;
D) the amount of bottoms liquid (the volume) is from 1 to 30% of the total volume of the amount of substance to be separated in the at least one dividing wall column;
E) a ratio of bottoms takeoff volume to the amount of feed is from 0.01 to 0.3;
F) packed columns with structured packings of a specific surface area of 100 to 1000 m2/m3 are used; and
G) a ratio of amount of reflux to amount of feed has a factor of from 0.5:1 to 5:1.

US Pat. No. 10,889,546

ALKYNYL PYRIDINE PROLYL HYDROXYLASE INHIBITOR, AND PREPARATION METHOD AND MEDICAL USE THEREOF

Jiangsu Hengrui Medicine ...

1. A compound of formula (I) or a pharmaceutically acceptable salt thereof:
wherein X represents NH, NCH3 or CH2;
Y represents hydrogen, hydroxy, methoxy or ethoxy;
L represents —CH2—, —CH2O— or
R6 represents hydrogen, C1-C4 alkyl or phenyl;n represents 1;
R1 represents C1-C4 alkyl, phenyl, quinolinyl, benzofuranyl, naphthyl, substituted phenyl, 5- to 6-membered heteroaryl containing oxygen or nitrogen, or substituted 5- to 6-membered heteroaryl containing oxygen or nitrogen, wherein the substituent is C1-C4 alkyl, C1-C4 alkoxy, C1-C4 haloalkyl, halogen, cyano,
phenyl or 5- to 6-membered heteroaryl containing oxygen or nitrogen, wherein R7 represents C1-C4 alkyl; R8 and R9 each independently represent hydrogen or C1-C4 alkyl, or R8 and R9 are attached to form a 3- to 7-membered heterocyclyl containing nitrogen;R2 represents hydrogen, halogen or methyl;
R3 and R4 each independently represent hydrogen, methyl or ethyl; and
R5 represents hydroxy, C1-C4 alkoxy, cyclopropoxy, or —NR10R11, wherein R10 and R11 each independently represent hydrogen, methyl or ethyl.

US Pat. No. 10,889,544

IONIC LIQUIDS COMPRISING HETERAROMATIC ANIONS

UNIVERSITY OF NOTRE DAME ...

1. An ionic liquid comprising an anion represented by a formula:
wherein X is N;
A is N or CR3;
E is N or CR4;
R1, R2, R3, and R4 are each independently H, halo, CN, CNO, NCO, NO2, R11, OR11, SR11, NR12R13, —YC(O)ZR11, SO2R11, SO3R11, or SO2NR12R13;
Y is a single bond, optionally substituted C1-6 hydrocarbyl, —N(R12)—, O, or S;
Z is a single bond, —N(R12)—, O, or S;
each R11 is H or optionally substituted C1-12 hydrocarbyl; and
each R12 and each R13 is independently H or optionally substituted C1-6 hydrocarbyl.

US Pat. No. 10,889,543

FINE-TUNE MODULATORS OF NEURONAL EXCITABILITY FOR NEUROPSYCHIATRIC DISORDERS

The Board of Regents of T...

1. A compound of Formula I or a pharmaceutically acceptable salt thereof, wherein:R1 and R3 are independently selected from H, alkyl, arylalklyl, —(C?O)R4, —(C?O)OR5, or Fmocwhere R4 is alkyl, arylalkyl, or aryl;
where R5 is alkyl, arylalkyl, or aryl;R2 is H, —OH, alkoxy, or —NR6R7;where R6 and R7 are independently selected from H, alkyl, aryl, or heteroaryl; or
R6 and R7 are optionally joined to form a N-containing heterocycle with 1-4 heteroatoms; andwherein if R2 is OH, then R1 and R3 are not both hydrogen.

US Pat. No. 10,889,542

PROCESS FOR PREPARING ELECTRON DEFICIENT OLEFINS

2. A one-pot process for the preparation of an electron deficient olefin, steps of which comprise:(a) providing as reactants:
(i) a 2-electron withdrawing group-substituted methylene compound embraced by:
wherein EWG represents an electron withdrawing group selected from the group consisting of cyano, halogens, nitro, isocyanate, sulfoxide and phosphine oxide; and R here represents straight chain, branched, cyclic or fused C1-20 alkyl, C2-20 alkenyl, C2-20 alkynyl, and C6-20 aryl or C7-20 alkaryl, with or without substitution or interruption by one or more heteroatoms; and(ii) an alcohol;wherein the alcohol is present in an amount of from 0.5 equivalents to 2 equivalents relative to the 2-electron withdrawing group-substituted methylene compound;(b) reacting the 2-electron withdrawing group-substituted methylene compound and the alcohol in the presence of a catalyst comprising a lanthanide element or a transition element, under appropriate conditions and for a time sufficient to yield an electron deficient olefin precursor embraced by:
wherein EWG represents an electron withdrawing group selected from the group consisting of cyano, halogens, nitro, isocyanate, sulfoxide and phosphine oxide; and R here represents straight chain, branched, cyclic or fused C1-20 alkyl, C2-20 alkenyl, C2-20 alkynyl, and C6-20 aryl or C7-20 alkaryl, with or without substitution or interruption by one or more heteroatoms, provided it is different from R in step (a)(i);(c) reacting the electron deficient olefin precursor and a source of aldehyde selected from the group consisting of formaldehyde, paraformaldehyde, formalin, 1,3,5-trioxane, methylene diacetate, dimethoxymethane, and acrolein in the presence of a catalyst comprising a lanthanide element wherein the lanthanide element comprises ytterbium, under appropriate conditions and for a time sufficient to yield an electron deficient olefin; and
(d) optionally, separating from the reaction mixture the so-formed electron deficient olefin to be substantially free from the reactants and by-products.

US Pat. No. 10,889,541

METHOD FOR PRODUCING N-VINYLFORMAMIDE

Mitsubishi Chemical Corpo...

1. A method for producing N-vinylformamide by a vapor phase thermal decomposition reaction using an evaporator for evaporating a raw material, a thermal decomposition reactor for thermally decomposing a raw material gas generated by the evaporator, and a condenser for condensing a thermally decomposed gas obtained by the thermal decomposition reactor, whereinevaporation of the raw material in the evaporator is started in a state in which a temperature of a pipe wall of a first connecting pipe for connecting the evaporator with the thermal decomposition reactor satisfies the following Equation (1):
temperature of pipe wall (° C.)?0.37×pressure of evaporator (mmHg)+205  Equation (1):

US Pat. No. 10,889,539

ANILINE PURIFICATION PROCESS

Covestro Deutschland AG, ...

1. A process for preparing pure aniline, comprising:a) providing a crude aniline fraction containing 80.000% by weight to 99.999% by weight of aniline and 0.001% by weight to 20.000% by weight of phenol, based on the total weight of aniline and phenol in the crude aniline fraction;
b) dividing the crude aniline fraction into a first partial stream and a second partial stream;
c) distilling the first partial stream in a first distillation column and distilling the second partial stream in a second distillation column, wherein the first distillation column is operated at a higher head pressure than the second distillation column, with the proviso that each of the first distillation column and the second distillation column is operated at a head pressure in the range from 1.0 mbar(abs.) to 500 mbar(abs.), and wherein from each of the first and the second distillation column,
a gaseous aniline distillate is removed as the overhead product and subsequently condensed, wherein a first partial stream of the condensed aniline distillate is returned to the first and/or the second distillation column as a reflux stream and a second partial stream of the condensed aniline distillate is removed as the product stream, and
a liquid bottom stream which is concentrated in phenol is removed, from which a first portion is partially or completely vaporised and is returned to the distillation column it originated from, and from which a second portion is discharged; and
d) using the heat released during the condensation of the aniline distillate from the first distillation column to provide the heat necessary for vaporising the first portion of the bottom stream from the second distillation column.

US Pat. No. 10,889,538

MEDIUM CHAIN FATTY ACID ESTERS OF BETA-HYDROXYBUTYRATE AND BUTANEDIOL AND COMPOSITIONS AND METHODS FOR USING SAME

The J. David Gladstone In...

1. A method of reducing epileptiform activity in the brain of a subject and/or treating in said subject one or more conditions selected from the group consisting of Alzheimer's disease, epilepsy, Parkinson's disease, heart failure, traumatic brain injury, stroke, hemorrhagic shock, acute lung injury after fluid resuscitation, acute kidney injury, myocardial infarction, myocardial ischemia, diabetes, glioblastoma multiforme, diabetic neuropathy, prostate cancer, amyotrophic lateral sclerosis, Huntington's disease, cutaneous T cell lymphoma, multiple myeloma, peripheral T cell lymphoma, HIV, and Niemann-Pick Type C disease said method comprising:administering to said subject, a therapeutically effective amount of a compound of Formula I:
wherein:R1 is H or C(1-6) alkyl or substituted alkyl; and
R2 and R3 are independently unsubstituted or substituted C(4-30) alkyl.

US Pat. No. 10,889,537

METHOD FOR PRODUCING FLUORINE-CONTAINING DIALKYL CARBONATE COMPOUNDS

SAMHWA PAINTS INDUSTRIES ...

1. A method for producing a dialkyl carbonate represented by the following Chemical Formula 3, comprising:reacting an alkyl chloroformate represented by the following Chemical Formula 1 and an alcohol represented by the following Chemical Formula 2 in the presence of a base,
wherein the base is one or two or more selected from 1-(methoxymethyl)imidazole, 1-(ethoxymethyl)imidazole, 1-(propoxymethyl)imidazole, 1-(butoxymethyl)imidazole, 1-(2-methoxyethyl)imidazole, 1-(2-ethoxyethyl)imidazole, 1-(2-propoxyethyl)imidazole, 1-(2-butoxyethyl)imidazole, 1-(3-methoxypropyl)imidazole, and 1-(3-ethoxypropyl)imidazole:

wherein, R1 and R2 are each independently an unsubstituted C1-C20 alkyl group and a fluorine-substituted C1-C20 alkyl group.

US Pat. No. 10,889,536

ENOL ETHERS

Eastman Chemical Company,...

1. A compound according to Formula I:
wherein:
A is
(a)

 wherein ** indicates the point of attachment, or
(b)(C3-8)cycloalkyl;
R1a is

R2 is ethyl, propyl, butyl, or pentyl;
R3 is methyl, ethyl, or propyl;
R4 is hydrogen, (C1-12)alkyl, (C2-12)alkenyl, or —C(O)R5;
R5 is (C1-12)alkyl unsubstituted or substituted by 1-2 R6, (C2-12)alkenyl unsubstituted or substituted by R6, (C3-8)cycloalkyl, or 5- to 9-membered aryl;
each R6 is (C1-4)alkoxy, or oxo; and
n is an integer from 1 to 15.

US Pat. No. 10,889,535

PROCESS AND APPARATUS FOR SEPARATING ETHYLENE

LG CHEM, LTD., Seoul (KR...

1. A process for separating ethylene from a feed stream comprising an initial C2 stream comprising acetylene, ethane and ethylene and a C3 stream comprising propylene, the process comprising the steps of:feeding the feed stream comprising the initial C2 stream and the C3 stream into a first deethanizer column to discharge a first C2 stream from a top of the first deethanizer column and the C3 stream from a bottom of the first deethanizer column;
feeding a portion of the first C2 stream discharged from the top of the first deethanizer column into a second deethanizer column and discharging a second C2 stream from a top of the second deethanizer column;
introducing a downstream discharge of the second deethanizer column into the first deethanizer column again to reflux the first deethanizer column;
supplying the second C2 stream into a first acetylene converter to convert acetylene contained in the second C2 stream into ethylene and discharging a first ethylene stream from the first acetylene converter;
supplying a remaining portion of the first C2 stream discharged from the top of the first deethanizer column to a second acetylene converter to convert acetylene contained in the remaining portion of the first C2 stream into ethylene and discharging a second ethylene stream from the second acetylene converter; and
feeding the first ethylene stream and the second ethylene stream into an ethylene separation column to obtain ethylene.

US Pat. No. 10,889,534

ALKYLATION PROCESSES USING LIQUID LEWIS ACID CATALYSTS

UOP LLC, Des Plains (IL)...

1. An alkylation process comprising:contacting a hydrocarbon feed comprising a butane with an olefin feed comprising a butene in the presence of a liquid Lewis acid catalyst and in the absence of hydrofluoric acid in an alkylation reaction zone under alkylation conditions to form a biphasic reaction mixture comprising alkylation products comprising trimethylpentanes and the liquid Lewis acid catalyst, wherein the liquid Lewis acid catalyst is a liquid reaction product of a donor molecule and a metal halide, wherein the metal in the metal halide is Al, wherein the donor molecule comprises caprolactam, N-methylcaprolactam, delta-valerolactone, tetrahydrofuran, caprolactone, alpha-acetolactone, beta-propiolactone, gamma-butyrolactone, morpholine, beta-propiolactam, gamma-butyrolactam, delta-valerolactam, or combinations thereof, wherein a mole fraction of the metal halide in the liquid Lewis acid is greater than about 0.5 to less than about 1;
separating the biphasic reaction mixture into the alkylation products and the liquid Lewis acid catalyst; and
recovering the alkylation products.

US Pat. No. 10,889,533

INLINE PROCESS TO MAKE ANTIFOULING AGENT CO-CATALYST FOR ETHYLENE OLIGOMERIZATION

Saudi Arabian Oil Company...

1. A process for selectively producing 1-butene, the process comprising the following two steps:Step 1: combining at least one antifouling agent and at least one aluminum alkyl compound to form an antifouling feed stream, wherein bringing the at least one antifouling agent into contact with the at least one aluminum alkyl compound forms at least one antifouling agent co-catalyst comprising the structure:

 or its dimeric form, wherein one or more of the chemical groups R1, R2, and R3 are antifouling groups comprising the structure —O((CH2)nO)mR4, wherein:
n is an integer of from 1 to 20;
m is an integer of from 1 to 100; and
R4 is a hydrocarbyl group;
wherein the chemical groups R1, R2, or R3 that do not comprise the antifouling group, if any, are hydrocarbyl groups, and
Step 2: feeding the antifouling feed stream, a catalyst comprising at least one titanate compound, and ethylene into a reactor and dimerizing ethylene to produce 1-butene, wherein the catalyst comprising at least one titanate compound is fed as a stream separate from the antifouling feed stream;
wherein a molar ratio of the at least one antifouling agent to the at least one aluminum alkyl compound provided to form the antifouling feed stream is varied in real-time via an inline mixer to adjust a ratio of the formed antifouling agent co-catalyst and residual aluminum alkyl compound or antifouling agent in the antifouling feed stream.

US Pat. No. 10,889,532

GRAPHENE/METAL OR METALLOID CORE-SHELL COMPOSITE AND MANUFACTURING METHOD THEREOF

HUBEI INSTITUTE OF AEROSP...

1. A method for preparing a graphene/metal or semi-metal composite material with shell-core structure, comprising following steps:1) introducing a surface functional group to graphene oxide to obtain a modified graphene oxide;
2) dissolving the modified graphene oxide in an organic solvent to obtain an organic solution of the modified graphene oxide;
3) adding a metal or a semi-metal into an organic solvent, stirring homogeneously, then dropping the organic solution of the modified graphene oxide and reacting to obtain a solution of coated graphene/metal or semi-metal; and
4) removing solvent from the solution of coated graphene/metal or semi-metal to obtain a graphene/metal or a semi-metal composite material with shell-core structure after drying.

US Pat. No. 10,889,531

METAL HYDRIDE NANOPARTICLES

The Government of the Uni...

1. A process comprising:reacting Ti(BH4)3 with LiAlH4 in an aprotic solvent while being sonicated to produce nanoparticles comprising titanium, boron, and hydrogen;
wherein the molar ratio of Ti(BH4)3 to LiAlH4 is from 1:1 to 1,000,000:1; and
annealing the nanoparticles under a vacuum.

US Pat. No. 10,889,529

ROCKET MOTOR PROPELLANTS, SYSTEMS AND/OR METHODS

1. A rocket motor propellant comprising:a low molecular weight hydroxyl-terminated polybutadiene (HTPB) polymer
and,the low molecular weight of the low molecular weight HTPB polymer being less than about 1500; and,
a high molecular weight diisocyanate,
D(NCO)2,
the molecular weight of the high molecular weight diisocyanate being greater than about 500;
the low molecular weight HTPB polymer and the high molecular weight diisocyanate being selected for their respective structures to provide for generating a resultant compound combination having a sufficiently low viscosity providing the properties of being
a liquid submix at room temperature, and,
low viscosity, the low viscosity being defined as sufficiently low to achieve the compound combination being:
mixed, cast and cured without the addition of heat.

US Pat. No. 10,889,528

ORGANIC LIQUID FERTILIZER

Bill Love, Overland Park...

10. A method of enhancing the nitrogen levels in soil comprising applying to the soil an aqueous liquid fertilizer comprising at least 4% dissolved ammoniacal nitrogen derived from a plant or animal-sourced waste filtrate.

US Pat. No. 10,889,526

ENVIRONMENTAL RESISTANT COATING MEMBER

Japan Fine Ceramics Cente...

1. An environmental resistant coating member comprising:a SiC fiber-reinforced ceramics substrate; and an environmental barrier coating layer provided on a whole surface of the SiC fiber-reinforced ceramics substrate, wherein
the environmental barrier coating layer comprises a SiAlON bonding layer formed on the SiC fiber-reinforced ceramics substrate, a mullite layer formed on the SiAlON bonding layer, a reaction inhibition layer formed on the mullite layer, and a gradient layer formed on the reaction inhibition layer and having a composition that gradually changes from a rare-earth disilicate to a rare-earth monosilicate, and
the reaction inhibition layer is at least one of an Al2O3 layer, a RE3Al5O12 layer, and a [(1-x)RE2SiO5-xRE2Si2O7] layer,
wherein RE is a rare-earth element and 0?x?1.

US Pat. No. 10,889,525

SOUND ABSORPTION MATERIAL PREPARATION METHOD, SOUND ABSORPTION MATERIAL AND FILLING METHOD THEREOF

Goertek Inc., Shandong (...

1. A sound absorption material preparation method, comprising the following steps:S1, preparing a non-foamed material slurry, and mixing the slurry uniformly;
S2, producing a combustible material framework and a cover-shaped container according to a set structure, and placing the combustible material framework in the cover-shaped container;
S3, forming the non-foamed material slurry in the cover-shaped container to form a wet formed body, and separating the wet formed body from the cover-shaped container;
S4, drying the wet formed body to form a dry formed body; and
S5, calcining the dried formed body, wherein the combustible material framework is burned off during the calcining step to form connected channels with a three-dimensional structure in the sound absorption material,
wherein:
the connected channels with the three-dimensional structure corresponds to the combustible material framework,
the connected channels with the three-dimensional structure and the combustible material framework have the set structure, and
the connected channels with the three-dimensional structure is formed to propagate a sound air flow.

US Pat. No. 10,889,522

WOLLASTONITE CRYSTALLIZED GLASS FOR ARTIFICIAL TOOTH AND METHOD FOR COLORING SAME

SOONCHUNHYANG UNIVERSITY ...

1. A method for coloring a wollastonite-based crystallized glass for an artificial tooth, the method comprising:(a) drying, weighing and ball-milling raw glass powders and coloring additive powders, wherein the raw glass powders includes SiO2, CaO, CaF2 and Na2O;
(b) introducing the ball-milled raw glass powders and coloring additive powders into a furnace, and calcining the powders therein at 950 to 1050° C. for 1 to 3 hours, and then cooling the powders to a room temperature;
(c) melting the calcined powders to form a glass, comprising increasing the calcined powders to 1400 to 1500° C. at an increase rate of 8 to 12° C./min, and then performing melting of the powders at 1400 to 1500° C. for 30 to 120 minutes;
(d) introducing the glass into a preheated mold at 450 to 550° C., preforming a thermal-stress removal heat-treatment of the glass at 450 to 550° C. for 1 to 3 hours, and cooling the glass to a room temperature; and
(e) preforming a two-steps crystallization heat-treatment of the glass and then cooling the glass to a room temperature to form a crystallized glass, wherein the two-steps crystallization heat-treatment includes a first heat-treatment of the glass at a nucleation temperature, and a second heat-treatment of the glass at a crystallization temperature.

US Pat. No. 10,889,521

GLASS PLATE AND FORMATION METHOD THEREOF

AGC INC., Chiyoda-ku (JP...

1. A glass plate having:a first surface; and
a second surface which is opposed to the first surface, wherein
the glass plate is curved around a first axis in such a manner that the first surface is a concave surface and the second surface is a convex surface,
in a cross sectional view of a plane that is perpendicular to the first axis,
at least both end portions of the second surface are chemically strengthened and compressive stress produced by ion exchange in both of the end portions of the second surface is larger than compressive stress produced by ion exchange in both end portions of the first surface, and
when an X axis is defined as a line including a line segment that connects one end point on the cross section of the second surface and a point, most distant from the one end point of the second surface, on the cross section of the second surface, a Y axis is defined as a line that passes a center point of the line segment and is perpendicular to the X axis, an origin is defined as an intersection of the X axis and the Y axis, and a positive direction of the Y axis is defined as a direction, going from a first surface side toward a second surface side, of the Y axis,
a second-order coefficient of a quadratic curve that approximates second-order differential values of a locus of a partial shape of a portion in a positive Y value region in the cross section of the second surface is negative,
wherein the second surface is chemically strengthened in its entirety, a virtual circular arc is defined as a circular arc around the origin that approximates the cross section of the second surface by a least squares method, and when the cross section of the second surface is compared with the virtual circular arc, a value obtained according to Formula (1) shown below is smaller than 0.02, where A is an average of absolute values of differences between each point on the cross section of the second surface and each point on the virtual circular arc in a radial direction going from the origin toward the virtual circular arc:
?/{L×(H/R)}  (1);whereR: a radius of curvature of the virtual circular arc;
H: a camber of the virtual circular arc; and
L: an arc length of the virtual circular arc.

US Pat. No. 10,889,520

GLASS FORMING APPARATUSES AND METHODS FOR MAKING GLASS RIBBONS

Corning Incorporated, Co...

1. A method for forming a laminated glass ribbon, the method comprising:directing streams of a molten core glass composition over a first outer forming surface and a second outer forming surface of a lower forming body such that the streams of the molten core glass composition converge and fuse at a root of the lower forming body thereby forming a core layer of the laminated glass ribbon;
directing streams of a molten cladding glass composition over a first outer forming surface and a second outer forming surface of an upper forming body positioned over the lower forming body such that the streams of the molten cladding glass composition contact the streams of the molten core glass composition thereby forming a first glass cladding layer and a second glass cladding layer of the laminated glass ribbon; and
extracting heat from the molten core glass composition flowing over the first outer forming surface and the second outer forming surface of the lower forming body with at least one first cooling tube extending substantially parallel to the first outer forming surface of the lower forming body and at least one second cooling tube extending substantially parallel to the second outer forming surface of the lower forming body, the lower forming body being disposed between the at least one first cooling tube and the at least one second cooling tube, wherein:
a first refractory material is disposed between the at least one first cooling tube and the first outer forming surface of the lower forming body and in direct contact with the at least one first cooling tube thereby forming a first continuous heat conduction pathway extending away from the first outer forming surface of the lower forming body in a substantially horizontal direction; and
a second refractory material is disposed between the at least one second cooling tube and the second outer forming surface and in direct contact with the at least one second cooling tube thereby forming a second continuous heat conduction pathway extending away from the second outer forming surface of the lower forming body in the substantially horizontal direction, the first continuous heat conduction pathway and the second continuous heat conduction pathway forming a vertical temperature gradient between the upper forming body and the lower forming body.

US Pat. No. 10,889,519

METHOD FOR MANUFACTURING GLASS ROLL

NIPPON ELECTRIC GLASS CO....

1. A method of producing a glass roll including a band-shaped glass film taken up into a roll shape, the method comprising:a conveying step of conveying the glass film along a longitudinal direction thereof;
a cutting step of irradiating the glass film with a laser beam from a laser irradiation apparatus while conveying the glass film by the conveying step, to thereby separate the glass film into a non-product portion and a product portion; and
a take-up step of taking up the product portion into a roll shape, to thereby form a glass roll,
wherein the cutting step comprises:
generating a thread-shaped peeled material from an end portion of the product portion in a width direction;
winding the thread-shaped peeled material around a rod-shaped collecting member, to thereby collect the thread-shaped peeled material; and
collecting the non-product portion, and
wherein the rod-shaped collecting member is arranged at a position above the glass film.

US Pat. No. 10,889,518

USE OF AN INORGANIC SALT OR ACID IN REDUCING THE HARDNESS AND/OR ALKALINITY OF A WATER SYSTEM

ECOLAB USA INC., St. Pau...

1. A method of reducing the hardness and/or alkalinity of water, comprising:adding a composition capable of delivering a fluoride ion and a phosphate ion to the water of a gasification black water system, wherein the composition comprises sodium fluoride or potassium fluoride, wherein the water comprises an organo-phosphorus anti-scalant in an amount greater than 0 to about 20 ppm, and
adding a flocculant to the water, wherein the flocculant is a polyacrylamide,
wherein the gasification black water system comprises
a furnace,
a water scrubber that receives gas from the furnace,
a medium flash tank that receives the water from the water scrubber,
a vacuum flash tank that receives the water from the medium flash tank,
a sediment tank that receives the water from the vacuum flash tank,
wherein the sodium fluoride or the potassium fluoride and the phosphate ion is added to the water in an amount totaling 40 to 60 ppm before the sediment tank or into the sediment tank,
wherein the polyacrylamide is added before the sediment tank or into the sediment tank.

US Pat. No. 10,889,517

NANOMETER PHOTOCATALYST-MICROBE COMPOSITE MULTILAYER LIGHT TRANSMISSION COMBINATION CARRIER

HOHAI UNIVERSITY, Jiangs...

1. A method of making a nano-photocatalyst-microorganism composite multilayered light-transmitting combination support, the nano-photocatalyst-microorganism composite multilayered light-transmitting combination support comprising: multiple layers of wave-shaped plexiglass plate square pieces, a tandem rod holder, hollow elastic spacers, and fixing screws; wherein the multiple layers of wave-shaped plexiglass plate square pieces are arranged in parallel and each of the wave-shaped plexiglass plate square pieces is provided with four fixing holes; the tandem rod holder is provided with four tandem rods, and the four tandem rods pass through corresponding fixing holes in each of the wave-shaped plexiglass plate square pieces arranged in parallel, respectively; the tandem rods between two adjacent wave-shaped plexiglass plate square pieces pass through the hollow elastic spacers; each of the tandem rods is provided with a fixing screw at the top end; and each of the wave-shaped plexiglass plate square pieces has different loading layers on the upper and lower surfaces, with a nano-photocatalyst-loading layer on one surface and a degrading bacteria-loading layer on the other surface; and the method comprising:(1) hot press molding and surface roughening of a raw plexiglass plate, comprising: hot pressing the raw plexiglass plate in a wave-shaped mold into a wave shape; cutting the raw plexiglass plate into wave-shaped plexiglass plate square pieces; roughening by sandblasting the upper and lower surfaces of the wave-shaped plexiglass plate square pieces; and cutting the wave-shaped plexiglass plate square pieces roughened by sandblasting to have circular fixing holes at the four corners;
(2) formation of the nano-photocatalyst-loading layer by loading two layers of films, comprising: ultrasonically cleaning the roughened wave-shaped plexiglass plate square pieces with dilute nitric acid, absolute ethanol and pure water sequentially at an ultrasonic frequency of 40 KHz and at a temperature of 35° C., each for 20 min; air drying the ultrasonically-cleaned wave-shaped plexiglass plate square pieces at room temperature; and then applying a layer of SiO2 on one surface of each wave-shaped plexiglass plate square piece by mechanical painting to increase the adhesion intensity of the nano-photocatalyst followed by applying a nano-photocatalyst on the one surface of each wave-shaped plexiglass plate square piece at normal temperature and pressure by three or more consecutive surface paintings, prior to rinsing with water and air drying at room temperature;
(3) formation of the degrading bacteria-loading layer by loading degrading bacteria;
(4) assembly by stacking the multiple layers of the plexiglass plate square pieces; and
(5) support securement and interlayer spacing adjustment.

US Pat. No. 10,889,516

SIPHON TYPE COMPOSITE VERTICAL SUBSURFACE FLOW CONSTRUCTED WETLAND

Energy Research Institute...

1. A siphon type composite vertical subsurface flow constructed wetland, comprising:an uplink pool and a downlink pool, a depth of the uplink pool being ¾ of a depth of the downlink pool;
siphon type drain tubes equidistantly distributed at a first outer side of the uplink pool driven by a depth difference between the uplink pool and the downlink pool, a total flow through the drain tubes being greater than a total influent flow; and
three layers of substrates on the uplink pool and the downlink pool, from top to bottom, a substrate on a first substrate layer being a biological ceramsite, another substrate on a second substrate layer being zeolite, a further substrate on a third substrate layer being cobblestone; the first substrate layer and the second substrate layer of the downlink pool and the first substrate layer and the second substrate layer of the uplink pool being separated by barriers, the third substrate layers of the downlink pool and the uplink pool being integrally communicated, and sewage in the downlink pool being configured to flow to the uplink pool through a communication port; and
wherein:
the biological ceramsite has a grain size smaller than that of the zeolite;
the zeolite has a grain size smaller than that of the cobblestone;
the first substrate layer comprises aerobic microbes adhered thereto for an aerobic sewage treatment;
at least one part of the first substrate layer is always in air; and
the siphon type drain tubes are configured to discharge sludge in the third substrate layer along with water.

US Pat. No. 10,889,515

SYSTEMS AND METHODS FOR FORMATION OF BIOLOGICALLY ACTIVE GRANULES AND BIOLOGICALLY ACTIVE GRANULES

BLUE FROG TECHNOLOGIES LL...

1. A system for the treatment of sludge in a lagoon containing water that promotes the formation of biologically active granules that digest sludge in the lagoon, the lagoon including a bottom thereof, the water of the lagoon having a surface layer, the system comprising: (i) X number of water circulators in a cluster having an impeller disposed in the lagoon, wherein X is greater than or equal to three, at least one of said X number of water circulators being configured to: (a) cavitate water taken from the lagoon; and (b) expel the water after cavitation, wherein the water is expelled from said impeller at constant impeller rotational speed at a cyclically varying flow rate radially across a surface of the lagoon from the centerline of each circulator such that at least some of the expelled water travels away from each of the water circulators in a path essentially parallel to the surface layer of the lagoon water and wherein at least some of the expelled water travels downward as a pulsed liquid flow towards the bottom of the lagoon; when said at least one water circulator is a number of water circulators less than X, the remainder of said X number of water circulators, other than said at least one water circulator, being configured to expel water taken from the lagoon, wherein the water is expelled from the remaining water circulator(s) such that at least some of the expelled water travels away from the water circulator in a path essentially parallel to the surface layer of the lagoon water; said X number of water circulators are disposed in the lagoon in a configuration such that: each water circulator is located essentially on a circumference of a circle defined by a predetermined radial distance from a center point of the circle and each water circulator is located essentially equidistant, along the circumference of the circle, from each adjacent one of the other water circulators; (ii) hydraulic wall formed from at least some of the water expelled from each of a given pair of adjacent water circulators, wherein each of the hydraulic walls intersects at a midpoint of any two adjacent circulators, said hydraulic wall redirecting the expelled water downward towards the bottom of the lagoon, and thereafter towards an inlet of the water circulator, thereby creating conditions for the formation of the biologically active granules; and (iii) a quiescent area in fluid communication and downstream from the water circulator that cavitated the water, and located in a redirected path of the expelled water towards the bottom of the lagoon, whereby the expelled water forms a water column in said quiescent area to stratify the biologically active granules into a plurality of layers according to their density.

US Pat. No. 10,889,514

WATER TREATMENT METHOD AND WATER TREATMENT APPARATUS

Panasonic Intellectual Pr...

1. A water treatment method using a water treatment apparatus that removes impurities, the method comprising:(a) providing the water treatment apparatus;
the water treatment apparatus including
a first tank that stores slurry containing photocatalytic particles,
a first light source that irradiates the photocatalytic particles with ultraviolet light within the first tank,
a flowmeter that measures an amount of an aqueous solution introduced into the first tank,
an ionic conductivity measuring meter that measures ionic conductivity of the aqueous solution introduced into the first tank,
a second tank into which part of the slurry in the first tank is introduced,
an introducing unit that introduces at least one selected from the group consisting of a marker molecule and a stain into the second tank,
a second light source that irradiates the second tank with visible light,
a detector that detects intensity of the visible light having transmitted through the second tank; and
an electronic circuit;
(b) introducing the aqueous solution containing impurities into the first tank;
(c) irradiating, from the first light source, the photocatalytic particles with ultraviolet light, to turn the aqueous solution into post-treatment water in which the impurities have been treated;
(d) measuring, with the flowmeter, an amount of the aqueous solution introduced into the first tank;
(e) measuring, with the ionic conductivity measuring meter, ionic conductivity of the aqueous solution introduced into the first tank;
(f) calculating, with the electronic circuit, a total amount of ions contained in a total amount of the aqueous solution introduced into the first tank, using the measured amount of the aqueous solution and the measured ionic conductivity of the aqueous solution;
(g) when the calculated total amount of ions is greater than a first threshold value, introducing part of the slurry in the first tank into the second tank;
(h) introducing, with the introducing unit, at least one selected from the group consisting of the marker molecule and the stain into the second tank;
(i) irradiating, from the second light source, the second tank with visible light;
(j) detecting, with the detector, first intensity of the visible light having transmitted through the second tank; and
(k) determining, with the electronic circuit, whether or not the photocatalytic particles have deteriorated based on whether or not activity of the photocatalytic particles calculated based on the first intensity is equal to or smaller than a second threshold value.

US Pat. No. 10,889,511

FLUID CONDITIONING AND TREATMENT SYSTEM

AQUATRON USA, INC., Pomp...

1. A fluid conditioning and treatment system, comprising:an electronic controller having a plurality of energy producing circuits with each of the plurality of energy producing circuits generating its own output signal, the electronic controller including a first oscillator configured as a variable pulse width, variable pulse rate generator and a second oscillator configured as a variable triangle wave generator arranged to control the frequency of the first oscillator;
an energy delivery module (“energy chamber”) in electrical communication with the electronic controller, the energy delivery module having a housing adapted for fluid communication securement with an existing fluid line, the housing having a wall defining an internal passageway, the energy delivery module having a plurality of electrodes protruding through the wall and extending into the internal passageway for contacting fluid flowing through the internal passageway and conveying energy received from the electronic controller to the fluid traveling through the internal passageway, the plurality of electrodes statically arranged with respect to each other, the plurality of electrodes grouped in pairs and each electrode group pair specifically associated with and only in electrical communication with a specific one of the plurality of energy producing circuits and not the remaining energy producing circuits of the plurality of energy producing circuits and only receives an output signal generated by the specific one of the plurality of energy producing circuits to avoid mixing of signals generated by the plurality of energy producing circuits.

US Pat. No. 10,889,510

SYSTEMS AND METHODS FOR SANITIZING POOL AND SPA WATER

Hayward Industries, Inc.,...

1. A sensor, comprising:a body having a generally cylindrical outer wall and defining a chamber;
a paddle wheel mounted within a recessed portion of the body, the paddle wheel in mechanical communication with a flow meter, the paddle wheel rotating when water flows past the sensor and the flow meter measuring a rate of water flow past the sensor when the paddle wheel rotates; and
a plurality of electrodes extending from the body, the plurality of electrodes contacting water flowing past the sensor and measuring a concentration of salt present in, and conductivity of, the water,
wherein the flow meter and the plurality of electrodes are in electrical communication with an electrical circuit.

US Pat. No. 10,889,509

ULTRAVIOLET LIGHT WATER TREATMENT UNIT FOR HIGH FLOW RATE SYSTEMS

EBBTIDES MEDICAL INC, (C...

1. A portable, liquid disinfection device for integration into a closed recirculation system, for use in heart surgery, which includes a heater-cooler unit (HCU), a cooling circuit in fluid communication with the HCU and an oxygenating circuit in fluid communication with the HCU, the portable, liquid disinfection device comprising: a housing which includes an inside upper surface and an inside lower surface, which is opposite the inside upper surface; a first external connector pair comprising a first external inlet line connector and a first external line outlet connector, which are for fluid connection with the cooling circuit; at least a second external connector pair comprising a second external inlet line connector and a second external line outlet connector, which are for fluid connection with the oxygenating circuit; and at least two units which are housed within the housing and are spaced apart from the inside lower surface, the inside upper surface and from one another, each unit including:at least one stainless steel cylinder, the cylinder defining a bore, the bore terminating in a first end and a second end, the cylinder including a mirrored, electropolished inner surface, an inlet in a vicinity of the first end and an outlet in a vicinity of the second end, both the inlet and the outlet disposed on an upper surface of the stainless steel cylinder and in fluid communication with the bore;
a quartz tube centrally located in the bore and extending between the first end and the second end, the bore and quartz tube defining a void volume which accommodates a flow rate of at least 15 liters of liquid per minute;
a high irradiance Ultraviolet-C (UV-C) light source housed in the quartz tube and extending a length of the quartz tube, the light source including a power connector, the light source optically unobstructed from the mirrored, electropolished inner surface along the length of the quartz tube;
an inlet line and an outlet line, the lines in fluid communication with the inlet and outlet, respectively and with one of the external connector pairs;
a first end cap and a second end cap, the end caps releasably sealing the first end and the second end, one of the first end cap and the second end cap including an orifice for the power connector to extend therefrom;
a ballast for the UV-C light source, the ballast in electrical communication with the power connector; and
a ballast control panel in electrical communication with the ballast.

US Pat. No. 10,889,505

VANADIUM OXIDE COMPOSITIONS AND SYSTEMS AND METHODS FOR CREATING THEM

Dimien, Inc., Amherst, N...

1. A liquid delivery system for creating targeted vanadium oxide (VO2) nanoparticle compositions comprising:a stock reaction mixture that is a liquid solution of at least one vanadium source combined with at least one dopant source, wherein each of said at least one dopant source contains at least one target dopant element, and wherein the ratio of the number of vanadium atoms in said vanadium source to the number of target dopant element atoms in said dopant source is less than or equal to 10:1; and
a selected solvent that is compatible with said stock reaction mixture;
wherein said solvent and said stock reaction mixture are maintained at an elevated pressure greater than atmospheric pressure and less than or equal to 5,000 psi via a back pressure regulator;
the temperature of said solvent is maintained to between 50 and 500° C., and
a continuous liquid flow of said stock reaction mixture is mixed with said solvent to heat said stock reaction mixture and initiate formation of the targeted vanadium oxide (VO2) nanoparticle composition.

US Pat. No. 10,889,504

OXIDE SEMICONDUCTOR COMPOSITION, MANUFACTURING METHOD THEREOF, THIN FILM TRANSISTOR AND DISPLAY APPARATUS

BOE TECHNOLOGY GROUP CO.,...

1. An oxide semiconductor composition, comprising indium oxide, zinc oxide, and an oxide comprising an element of scandium; wherein the oxide semiconductor composition has a formula of In2Sc2ZnO7.

US Pat. No. 10,889,502

DIRECT SYNTHESIS OF A MICROPOROUS ALUMINOSILICATE MATERIAL HAVING AN AFX STRUCTURE AND COMPRISING COPPER, AND USE OF SAID MATERIAL

IFP ENERGIES NOUVELLES, ...

1. A process for preparing a copper-containing microporous aluminosilicate material with AFX structure, comprising at least the following steps:a) mixing, in an aqueous medium, of at least one aluminum source, at least one silicon source, sodium hydroxide, at least one copper source, an organic complexing agent (OCPLX) chosen from triethylenetetramine (TETA) or tetraethylenepentamine (TEPA) and a structuring agent 1,4-diazabicyclo[2.2.2]octane-C4-diquat dibromide (DABCO-C4), in order to obtain a gel of molar composition:
aSiO2:bAl2O3:cNa2O:dDABCO-C4:eCuO:fOCPLX:gH2O
a/b being between 100 and 40, c/b being between 25 and 50, d/b being between 3 and 10, e/b being between 0.05 and 0.1, f/e being between 1 and 1.5 and g/b being between 4000 and 1000;
b) hydrothermal treatment of the gel at a temperature of between 130 and 180° C., under an autogenous reaction pressure, for a period of between 1 and 8 days with stirring in order to obtain the crystallization of the copper-comprising microporous aluminosilicate material with AFX structure;
c) drying heat treatment of the solid obtained at the end of the preceding step at a temperature of between 80 and 120° C. under a stream of inert gas followed by calcining under dry air at a temperature of between 400 and 600° C.;
d) ion exchange comprising bringing the solid obtained the end of the preceding step into contact with a solution comprising a species capable of releasing copper in solution in reactive form with stirring at ambient temperature for a period of between 1 h and 2 d;
e) drying heat treatment of the solid obtained at the end of the preceding step at a temperature of between 80 and 120° C. followed by calcining under a stream of inert gas and then air at a temperature of between 400 and 600° C.;
the total amount of copper contained in the material obtained at the end of the preparation process being between 1.5 and 5.75% by weight relative to the total weight of the material in its anhydrous form.

US Pat. No. 10,889,501

SOLAR THERMAL AEROGEL RECEIVER AND MATERIALS THEREFOR

Massachusetts Institute o...

1. A solar thermal aerogel receiver comprising:an opaque frame defining an opening;
an aerogel layer disposed in the opaque frame, with at least a portion of the aerogel layer being disposed proximate the opening; and
a heat transfer fluid pipe in thermal contact with and proximate the aerogel layer.

US Pat. No. 10,889,500

METHODS FOR PRODUCING GRAPHENE FROM COAL

Carbon Holdings Intellect...

1. A method of producing reduced graphene oxide, comprising:thermally processing an amount of coal to achieve a predetermined concentration of an one or more impurity atoms in the amount of coal;
oxidizing at least some of the amount of coal to form a coal oxide including a predetermined concentration of the one or more impurity atoms;
processing the coal oxide to form reduced graphene oxide including a predetermined concentration between about 0.1 atomic % and about 10 atomic % of the one or more impurity atoms.

US Pat. No. 10,889,499

DEGRADABLE CONJUGATED POLYMERS

The Board of Trustees of ...

1. A process for separating semiconducting single-walled carbon nanotubes from a mixture of semiconducting and metallic single-walled carbon nanotubes, the process comprising:(i) providing a mixture A of semiconducting and metallic single-walled carbon nanotubes,
(ii) dispersing the mixture A in a solvent using a degradable polymer comprising at least one unit of formula (1):

wherein
T1 is a carbon atom or a nitrogen atom,
T2 is a carbon atom if T1 is a nitrogen atom, or is a nitrogen atom if T1 is a carbon atom,
r is 1, 2, 3 or 4,
s is 1, 2, 3, or 4,
wherein M1 is selected from the group consisting of

and M2 is selected from the group consisting of

wherein
R1 is C1-36-alkyl,
R102 and R103 are independently selected from the group consisting of H and C1-20-alkyl, which is optionally prepared through a direct condensation of diamines comprising r units of M1 and dialdehydes comprising s units of M2 or of dialdehydes comprising r units of M1 and diamines comprising s units of M2, as a dispersing agent to obtain a dispersion B comprising the semiconducting single-walled carbon nanotubes in a solvent, the dispersion B further comprising metallic single-walled carbon nanotubes,
(iii) separating the metallic single-walled carbon nanotubes from the dispersion B, to obtain an enriched dispersion C of the semiconducting single-walled carbon nanotubes in a solvent,
(iv) degrading by hydrolysis the degradable polymer in the enriched dispersion C, and
(v) separating the semiconducting single-walled carbon nanotubes from a solution D comprising a solvent and the degradable polymer.

US Pat. No. 10,889,498

DRAWING DEVICE AND DRAWING METHOD

LINTEC CORPORATION, Toky...

4. A method of drawing an extended form from a grown form produced by growing carbon nanotubes, the method comprising:moving one of the grown form and a holding member closer to another of the grown form and the holding member to hold a part of the grown form with the holding member;
winding the part of the grown form around the holding member; and
moving the one of the grown form and the holding member away from the another of the grown form and the holding member to draw the extended form from the grown form.

US Pat. No. 10,889,497

SHEET-SHAPED NITROGEN-PHOSPHORUS CO-DOPED POROUS CARBON MATERIAL AND METHOD FOR PREPARATION THEREOF AND USE THEREOF

1. A sheet-shaped nitrogen-phosphorus co-doped porous carbon material, wherein prepared and obtained according to the following method:(1) mixing aniline and hexachlorocyclotriphosphazene, undergoing a closed reaction for 2-24 h at a pressure of 1-10 MPa and a temperature of 140-260° C., then pressure is released to atmospheric pressure and steam drying is performed to obtain a solid substance;
the volume of the aniline is 3-300 mL/g by the mass of the hexachlorocyclotriphosphazene;
(2) under inert gas protection, the obtained solid substance in step (1) is treated for 1-6 h at a high temperature of 400-1000, and the sheet-shaped nitrogen-phosphorus co-doped porous carbon material is obtained.

US Pat. No. 10,889,496

METHOD FOR THE PREPARATION OF SYNTHESIS GAS

1. Method for the preparation of synthesis gas comprising the steps of:(a) preparing a separate hydrogen containing stream and a separate oxygen containing stream by electrolysis of water and/or steam;
(b) providing a hydrocarbon feedstock;
(c1) steam reforming a part of the hydrocarbon feedstock from step (b), and/or a second hydrocarbon feedstock, by indirect heat transfer with part or all of an autothermal reformed gas leaving step (d), to obtain a steam reformed gas stream, and mixing the steam reformed gas stream with the autothermal reformed gas downstream of step (d); or
(c2) heat exchange steam reforming a part or all of the hydrocarbon feedstock from step (b), by indirect heat transfer with part or all of an autothermal reformed gas leaving step (d), to obtain a steam reformed gas, and introducing the steam reformed gas into an autothermal reformer in step (d) to obtain the autothermal reformed gas for use in step (c2);
(d) producing, as an exit gas in an autothermal reformer, the autothermal reformed gas for use in step (c1) or step (c2) by autothermal reforming a part of the hydrocarbon feedstock from step (b) or at least a part of the steam reformed gas from step (c2), with at least a part of the separate oxygen containing stream from step (a);
(e) introducing at least part of the separate hydrogen containing stream from step (a) into the mixed heat exchange reformed gas and autothermal reformed gas downstream step (c1) or into the autothermal reformed gas downstream step (d) to obtain a synthesis gas comprising hydrogen, carbon monoxide and carbon dioxide; and
(f) withdrawing a synthesis gas.

US Pat. No. 10,889,495

METHOD FOR STABLE ETHANOL STEAM REFORMING

1. A method for ethanol steam reforming, comprising carrying out ethanol catalytic steam reforming in two vessels, a first vessel and a second vessel operating in parallel, each vessel filled in with a catalyst active for ethanol catalytic steam reforming and the vessels alternately performing ethanol catalytic steam reforming and a catalyst regeneration, wherein, while the first vessel, acting in an ethanol catalytic steam reforming mode, is made flowing with an ethanol rich gaseous stream under pressure to generate a hydrogen rich stream, the second vessel, acting in a catalyst regeneration mode, is made flowing with superheated steam at a pressure lower than the pressure under which the ethanol rich gaseous stream is flowing in order to carry out gasification of carbonaceous compounds deposited on the catalyst, and wherein the catalyst regeneration is carried out at a temperature higher than the temperature at which the ethanol catalytic steam reforming is carried out, both temperatures being lower than or equal to 600° C.

US Pat. No. 10,889,494

GRAPHENE OXIDE/METAL NANOCRYSTAL MULTILAMINATES THE ATOMIC LIMIT FOR SAFE, SELECTIVE HYDROGEN STORAGE

The Regents of the Univer...

1. A composition of matter comprising:a reduced graphene oxide (rGO)-magnesium (Mg) nanocrystal nanolaminate, the nanolaminate comprising two rGO sheets with Mg nanocrystals distributed therebetween, the nanolaminate having a hydrogen storage capacity of approximately 6.5 weight percent hydrogen and 0.105 kg H2/L, the hydrogen storage capacity of the nanolaminate being equivalent to approximately 7.56 weight percent hydrogen in the Mg nanocrystals.

US Pat. No. 10,889,493

MEMS METHOD AND STRUCTURE

Taiwan Semiconductor Manu...

1. A method of manufacturing a microelectromechanical structure, the method comprising:forming a support film on a first surface of a first substrate, the first substrate comprising two support regions and a movable mass region between the two support regions, the support film covering first areas of the first surface of the first substrate and exposing second areas of the first surface of the first substrate;
after forming the support film, bonding the second areas of the first surface of the first substrate to a second substrate; and
after the bonding, separating the movable mass region from the two support regions by removing portions of the first substrate between the two support regions and the movable mass region, wherein separating the movable mass region separates the support film into a first segment attached to the movable mass region and second segments attached to the two support regions, wherein the first segment of the support film has a first side facing the second substrate and has a second side facing away from the second substrate, the second side being fully covered by the movable mass region.

US Pat. No. 10,889,492

METHODS FOR PRODUCING THIN-FILM LAYERS AND MICROSYSTEMS HAVING THIN-FILM LAYERS

INFINEON TECHNOLOGIES AG,...

1. A method for producing a thin-film layer, wherein the method comprises:providing a carrier substrate;
providing a layer stack on the carrier substrate, wherein the layer stack comprises a carrier layer and a sacrificial layer, wherein the sacrificial layer comprises areas in which the carrier layer is exposed;
providing the thin-film layer on the layer stack, such that the thin-film layer bears on the sacrificial layer and, in the areas of the sacrificial layer in which the carrier layer is exposed, against the carrier layer;
at least partly removing the sacrificial layer proceeding from the thin-film layer in order to eliminate a contact between the thin-film layer and the sacrificial layer at least in areas; and
detaching the thin-film layer from the carrier layer.

US Pat. No. 10,889,491

METHOD FOR PRODUCING A MICROMECHANICAL ELEMENT

Robert Bosch GmbH, Stutt...

1. A method for producing a micromechanical element, the method comprising:producing a micromechanical structure having a functional layer for a micromechanical element, a sacrificial layer at least partially above the functional layer and at least partly surrounding the functional layer, and a closure cap on an upper surface of the sacrificial layer;
applying a cover layer on an upper surface of the closure cap of the micromechanical structure;
producing a grid structure in the cover layer;
producing a cavity in the closure cap below the grid structure, as access to the sacrificial layer;
at least partly removing the sacrificial layer; and
applying a closure layer at least on the grid structure of the cover layer to close the access to the cavity.

US Pat. No. 10,889,490

ELECTROTHERMALLY ACTUATED MICROELECTROMECHANICAL AND/OR NANOELECTROMECHANICAL STRUCTURE PROVIDING INCREASED EFFICIENCY

1. An electrothermally actuated device comprising:at least one of a microelectromechanical structure and a nanoelectromechanical structure, said at least one of the microelectromechanical structure and the nanoelectromechanical structure comprising
a fixed part,
at least one movable part configured to move with respect to the fixed part,
at least one set of several electrothermal actuation beams configured to flow an electric current from the fixed part to the movable part, to mechanically connect to the movable part, and configured to simultaneously apply an electrothermal force having a same direction on the movable part, and
at least one electrically conducting connecting element configured to electrically connect the movable part to the fixed part,
wherein the set of several electrothermal actuation beams has a cross-sectional thickness lower than or equal to half a thickness of the movable part and lower than or equal to half a thickness of the at least one electrically conducting connecting element, and the electrothermal actuation beams are nanowires.

US Pat. No. 10,889,489

COMPOSITE CUSHIONS

Joseph T. Nilson, Alpine...

1. A composite cushioning element, comprising:a first cushioning element comprising a first cushioning structure, the first cushioning element including:
a central cushioning area having a central cushion thickness, a first cushioning material of the central cushioning area forming the first cushioning structure, including walls defining an outer periphery of the central cushioning area and columnar cushioning cells within the outer periphery, the first cushioning material enabling the walls and the columnar cells to buckle, a first surface of the central cushioning area defined by first ends of the walls and coincident with first ends of the columnar cushioning cells, a second surface of the central cushioning area opposite from the first surface, defined by second ends of the walls opposite from the first ends of the walls, and coincident with second ends of the columnar cushioning cells opposite from the first ends of the columnar cushioning cells;
a peripheral engagement area located outside of and adjacent to at least a portion of the outer periphery of the central cushioning area, the peripheral engagement area having an engagement thickness, the peripheral engagement area defined by the first cushioning material defining engagement cells adjacent to the outer periphery, a first surface of the peripheral engagement area corresponding to the first surface of the central cushioning area and coincident with first ends of the engagement cells, a second surface of the peripheral engagement area opposite from the first surface and corresponding to the second surface of the central cushioning area and coincident with second ends of the engagement cells, the second ends of the engagement cells opposite from the first ends of the engagement cells;
a second cushioning element comprising a second cushioning structure adjacent to at least a portion of the outer periphery of the central cushioning area of the first cushioning element, a second cushioning material including features formed complementarily to the peripheral engagement area to mechanically secure the second cushioning element to the first cushioning element.

US Pat. No. 10,889,488

MULTI-COMPARTMENT TANKER

1. An apparatus, comprising:a first liquid storage tank;
a second liquid storage tank;
one or more valves, the one or more valves connecting the first liquid storage tank to the second liquid storage tank; and
a vacuum pump, the vacuum pump connected to the first and second liquid storage tanks and operable for facilitating transfer of at least a portion of a liquid in the first liquid storage tank to the second storage tank in response to a valve connecting the first and second storage tanks being opened, the vacuum pump simultaneously pressurizing the first liquid storage tank while sucking air from the second liquid storage tank to create a pressure differential between the first liquid storage tank and the second liquid storage tank to transfer the at least a portion of the liquid from the first liquid storage tank to the second liquid storage tank.

US Pat. No. 10,889,487

FUEL TRANSFER STATION AND REFILLABLE FUEL CELL FOR FUEL TRANSFER STATION

WORTHINGTON CYLINDERS COR...

1. A closed loop fuel transfer station, comprising:a first connection port;
a second connection port;
a fluid flow line connecting the first connection port and the second connection port, the fluid flow line having an inlet portion proximate the first connection port and an outlet portion proximate the second connection port;
a first coupler configured to detachably couple a supply tank to the fluid flow line at the first connection port;
a second coupler configured to detachably couple a refillable fuel canister to the fluid flow line at the second connection port;
a first check valve at the inlet portion of the fluid flow line;
a second check valve at the outlet portion of the fluid flow line; and
a pump in fluid communication with the fluid flow line, so as to selectively pressurize the fluid flow line.

US Pat. No. 10,889,486

DISPENSING AND/OR DOSING SYSTEM

1. A dispensing and/or dosing system, comprising:an inverted liquid container having upper and lower ends;
said lower end of said container having a hollow throat extending downwardly therefrom which has interior and exterior surfaces;
said exterior surface of said throat being threaded;
a tricuspid valve, having upper and lower ends, positioned in said throat of said container;
said tricuspid valve being normally closed;
a horizontally disposed support shelf having a circular opening formed therein;
a mounting ring positioned on said shelf and having a central opening formed therein which registers with said circular opening of said support shelf;
said mounting ring having a plurality of radially spaced-apart vent openings formed thereto;
a vent ring positioned on said mounting ring and being secured thereto;
said vent ring having a central opening formed therein which registers with said central opening in said mounting ring;
said central opening of said vent ring being internally threaded;
said vent ring having a plurality of radially spaced-apart vent openings formed therein;
each of said vent openings of said vent ring having a normally closed slit valve associated therewith which permits air to pair therethrough but preventing liquid from passing therethrough;
said vent openings in said vent ring being in communication with said vent openings in said mounting ring;
said threaded exterior surface of said throat of said container being threadably secured to said internal threads of said central opening of said vent ring whereby said lower end of said tricuspid valve is in communication with said central opening of said vent ring;
a cylindrical and hollow accumulator having an open upper end and a bottom wall;
said bottom wall of said accumulator having a circular first valve seat formed therein;
said upper end of said accumulator being received in said circular opening of said support shelf and being secured therein by said mounting ring;
a hollow dosing cup comprising:
(a) a hollow ring-shaped and horizontally disposed upper wall portion having an upper end, a lower end, an outer surface and an inside surface which is threaded;
(b) a hollow and generally shaped conical-shaped wall portion having an open upper end, an open lower end, an outer surface and an inner surface;
(c) said hollow and said generally shaped conical-shaped wall portion extending downwardly and inwardly from said lower end of said upper wall portion;
(d) a hollow and cylindrical lower wall portion having an open upper end and an open lower end;
(e) said hollow and cylindrical lower wall portion extending downwardly from said lower end of said hollow and said generally shaped conical-shaped wall portion;
(f) said upper end of said upper wall portion being threadably secured to said lower end of said accumulator;
(g) said dosing cup having a circular second valve seat positioned between said lower end of said generally conical-shaped wall portion and said upper end of said lower wall portion of said dosing cup;
a vertically disposed and cylindrical actuator having an open upper end, an open lower end, an outer side and an inner side;
said actuator slidably embracing said hollow and cylindrical lower wall portion of said dosing cup;
said actuator being selectively movable between upper and lower positions with respect to said lower wall portion of said dosing cup;
an elongated actuator rod, having an upper end and a lower end, which includes:
(a) a disc-shaped upper valve secured to said actuator rod below said upper end thereof; and
(b) a disc-shaped lower valve secured to said actuator rod above said lower end thereof;
said lower end of said actuator rod being operatively secured to said actuator for vertical movement with said actuator between upper and lower positions;
a pointed lance member at said upper end of said actuator rod;
said pointed lance member creating a liquid discharge opening in said tricuspid valve when said actuator rod and said actuator are in said upper positions;
said disc-shaped upper valve of said actuator rod being in engagement with said first valve seat to close said first valve seat when said actuator and said actuator rod are in said upper positions;
said disc-shaped lower valve of said actuator rod being spaced above said second valve seat when said actuator and said actuator rod are in said upper positions;
said disc-shaped upper valve of said actuator rod being spaced below said first valve seat when said actuator and said actuator rod are in said lower positions; and
said disc-shaped lower valve of said actuator rod being in engagement with said second valve seat to close said second valve seat when said actuator and said actuator rod are in said lower positions.

US Pat. No. 10,889,484

SYSTEM AND METHOD FOR SENSING A LIQUID LEVEL IN AN AUTOFILL PITCHER USING VIBRATIONS

Haier US Appliance Soluti...

17. A method for dispensing liquid into a container, the method comprising:flowing liquid into the container;
propagating, by causing a lever arm of a vibration generator to contact the container, one or more vibrations through the container at predetermined intervals;
measuring, via a measurement device, a characteristic of the one or more vibrations propagating through the container at the predetermined intervals;
receiving, by a controller, one or more signals indicative of the characteristic of the one or more vibrations propagating through the container at the predetermined intervals;
determining, by the controller, a liquid level of liquid within the container based at least in part on the one or more signals indicative of the characteristic of the one or more vibrations propagating through the container at the predetermined intervals.

US Pat. No. 10,889,483

WATER PURIFIER

LG ELECTRONICS INC., Seo...

1. A liquid dispenser comprising:a case; and
a dispenser coupled to the case, wherein the dispenser includes:
a dispenser side cover coupled to the case;
a stationary cover coupled to the dispenser side cover;
an adjustable cover configured to be movable within the stationary cover; and
a dispenser nozzle installed at the adjustable cover and configured to discharge liquid,
wherein the stationary cover includes a guide rail that extends in a vertical direction,
wherein the adjustable cover includes a coupling bracket including at least one magnet positioned to be on one side of the guide rail so that an attractive magnetic force is applied to the guide rail, and
wherein as the adjustable cover is moved with respect to the stationary cover, the coupling bracket is moved along the guide rail.

US Pat. No. 10,889,482

PORTABLE BEVERAGE CONTAINER SYSTEMS AND METHODS FOR ADJUSTING THE COMPOSITION OF A BEVERAGE

LifeFuels, Inc., Reston,...

1. A beverage apparatus, the beverage apparatus being hand-holdable by a user of the beverage apparatus so as to be portable, the beverage apparatus comprising:a beverage chamber housing that includes a chamber, and the chamber storing a consumable liquid in the chamber;
a dispensing assembly that includes a first receptacle and second receptacle,
a first vessel that includes a first electronic tag and contains a first additive, and the first receptacle retaining the first vessel, and
a second vessel that includes a second electronic tag and contains a second additive, and the second receptacle retaining the second vessel; and
the dispensing assembly operatively controllable by a controller to (a) output the first additive from the first vessel into the consumable liquid in the chamber, and (b) output the second additive from the second vessel into the consumable liquid in the chamber;
an apparatus computer processor (ACP);
an apparatus database portion that includes instructions that are performed by the ACP in operation of the beverage apparatus, and the controller including the ACP and the apparatus database portion;
a first antenna that is associated with the first receptacle, and the first antenna for transferring data with the first electronic tag;
a second antenna that is associated with the second receptacle, and the second antenna for transferring data with the second electronic tag;
a transceiver that performs processing of data, and the transceiver in communication with the ACP; and the processing of data including:
the transceiver interfacing with the first antenna to provide first data transfer, and
the transceiver interfacing with the second antenna to provide second data transfer, and
a selection portion that performs controlling to control (a) the first data transfer, and (b) the second data transfer.

US Pat. No. 10,889,481

SYSTEM AND APPARATUS FOR OPTIMIZING HYDRATION AND FOR THE CONTEXTUAL DISPENSING OF ADDITIVES

LifeFuels, Inc., Reston,...

1. A portable container for retaining a consumable liquid, the portable container comprising:a hydration container that retains the consumable liquid;
an additive vessel containing an additive; and
a dispensing module mounted to the hydration container, the dispensing module receives the additive vessel; and
the dispensing module dispensing, into the consumable liquid in the hydration container, variable quantities of the additive;
at least one processor, associated with a first data store that stores first data, configured to adaptively control the dispensing module to perform the dispensing the variable quantities of the additive based on the first data;
the additive vessel associated with a second data store that stores second data; and
the at least one processor effecting transfer of transferred data between the first data store and the second data store; and
the additive vessel including at least one wall that contacts and contains the additive,
the dispensing module applying pressure to the at least one wall to dispense, in the dispensing, the variable quantities of the additive, and
the at least one wall, of the additive vessel, positioned in the dispensing module.

US Pat. No. 10,889,480

PRECISE FILL DISPENSING SYSTEM FOR AN APPLIANCE

Haier US Appliance Soluti...

1. A dispensing system for dispensing fluid to a downstream assembly of an appliance, the dispensing system comprising:a housing defining a chamber;
a piston movable within the chamber of the housing between a first position and a second position, the piston fluidly separating a first reservoir and a second reservoir of the chamber;
a first inlet conduit in fluid communication with a water supply and the first reservoir of the chamber;
a first valve positioned along the first inlet conduit and movable between an open position and a closed position, the first valve configured to selectively allow fluid to flow from the water supply to the first reservoir of the chamber;
a second inlet conduit in fluid communication with the water supply and the second reservoir of the chamber;
a second valve positioned along the second inlet conduit and movable between an open position and a closed position, the second valve configured to selectively allow fluid to flow from the water supply to the second reservoir of the chamber;
a first outlet conduit in fluid communication with the first reservoir of the chamber and the downstream assembly;
a third valve positioned along the first outlet conduit and movable between an open position and a closed position, the third valve configured to selectively allow fluid to flow from the first reservoir to the downstream assembly;
a second outlet conduit in fluid communication with the second reservoir of the chamber and the downstream assembly;
a fourth valve positioned along the second outlet conduit and movable between an open position and a closed position, the fourth valve configured to selectively allow fluid to flow from the second reservoir to the downstream assembly;
a sensor positioned at or proximate one of the first position and the second position, the sensor operable to detect the piston when the piston is in the one of the first position and the second position within the chamber; and
a controller communicatively coupled with the first valve, the second valve, the third valve, the fourth valve, and the sensor, the controller configured to:
receive a fill command signal;
receive a location signal from the sensor indicating a position of the piston;
control the first valve to the open position to allow fluid to flow from the water supply to the first reservoir of the chamber, wherein the piston is moved from the first position to the second position when the first valve is moved to the open position; and
control the fourth valve to the open position to allow fluid to flow from the second reservoir of the chamber to the downstream assembly.

US Pat. No. 10,889,479

BOTTLE OPENER CORK REMOVER

WINE UP LTD., Ramat Beit...

1. A device for removing a cork from a bottle, the device comprising:(a) a hollow needle, adapted to be inserted in the cork; and
(b) pressurized gas sealed in an inner volume of a prepackaged container; wherein said pressurized gas is adapted to be released from said container when a path of fluid communication is formed between a proximal end of said hollow needle and said inner volume of said container, such that said pressurized gas is channeled through said hollow needle, and into the cork or into the bottle, below the cork thereby forcing the cork out of the bottle;
wherein said device has a rest state and a release state, wherein in said rest state, a barrier interposes between said proximal end of said hollow needle and said inner volume, and in said release state said fluid path is formed between said inner volume of said container and said proximal end of said hollow needle, such that said pressurized gas is released from said container into said hollow needle.

US Pat. No. 10,889,478

CONTROL CONSOLE AND AERIAL LIFT INCLUDING SUCH A CONTROL CONSOLE

1. A control console for an aerial lift including a chassis, a platform, and a lift structure connecting the chassis to the platform, the control console comprising:manual control members for controlling the aerial lift, wherein each of the manual control members can be actuated in at least two actuating directions when the aerial lift is in a suitable operating condition for movement in at least two movement directions corresponding to the at least two actuating directions; and
for at least one of the manual control members, lighted indicators are provided on or around the at least one manual control member,
the lighted indicators emitting color lighted signals indicating when the at least one manual control member is actuatable in a possible actuating direction to perform movement of the aerial lift in the movement direction corresponding to the possible actuating direction, as a function of a current operating condition of the aerial lift being able to move in the movement direction corresponding to the possible actuating direction,
wherein a first one of the lighted indicators emitting the color lighted signals indicates when the at least one manual control member is actuatable in a first of the two actuating directions to perform a first movement of the aerial lift commanded by actuation of the at least one manual control member in the first of the two actuating directions,
wherein, when the first one of the lighted indicators does not emit the color lighted signals, this indicates that the at least one manual control member is not actuatable in the first actuating direction to perform the first movement of the aerial lift in the first movement direction as the aerial lift is not able to move in the first movement direction based on the current operating condition of the aerial lift,
wherein a second one of the lighted indicators emitting the color lighted signals indicates when the at least one manual control member is actuatable in a second of the two actuating directions to perform a second movement of the aerial lift commanded by actuation of the at least one manual control member in the second of the two actuating directions, and
wherein, when the second one of the lighted indicators does not emit the color lighted signals it indicates that the at least one manual control member is not actuatable in the second actuating direction to perform the second movement of the aerial lift in the second movement direction as the aerial lift is not able to move in the second movement direction based the current operating condition of the aerial lift.

US Pat. No. 10,889,477

INFLATABLE AIR WEDGE WITH TOOL CHANNEL AND ASSOCIATED METHOD

Xtreme Air Wedge, LLC, J...

1. An inflatable air wedge for allowing an operator to unlock an existing door of a vehicle without damaging an existing body or the existing door of the vehicle or the associated weather stripping of the existing body and the existing door of the vehicle, said inflatable air wedge comprising: a selectively inflatable bladder capable of being intercalated between the existing vehicle door and the existing vehicle body; a pneumatic mechanism in operable communication with said bladder for selectively introducing and releasing air from said bladder; and a flexible insert located within said bladder and spanning within a major surface area of said bladder, said flexible insert being pliable and resilient; a conduit engaged with said bladder, said conduit being suitably sized and shaped for guiding an existing unlocking tool therethrough while said bladder is at an inflated state and seated between the vehicle door and the vehicle body; wherein said conduit is spaced from said pneumatic mechanism and manually distended; wherein said bladder has a first centrally registered longitudinal axis; wherein said conduit has a second centrally registered longitudinal axis angularly offset about 45 degrees from said first centrally registered longitudinal axis; wherein said bladder has a first plurality of peripheral edges conjoined at a first end-to-end configuration; wherein said insert has a second plurality of peripheral edges conjoined at a second end-to-end configuration and disposed substantially parallel to said first plurality of peripheral edges, respectively; wherein said first plurality of peripheral edges comprises a first peripheral edge and a second peripheral edge equidistantly spaced apart on opposite sides of the first centrally registered longitudinal axis, wherein each of said first peripheral edge and said second peripheral edge are oriented parallel relative to the first centrally registered longitudinal axis and further oriented approximately 45 degrees relative to the second centrally registered longitudinal axis; wherein said first plurality of peripheral edges further comprises a third peripheral edge conjoined to said conduit, wherein said third peripheral edge is oriented about 45 degrees relative to the first centrally registered longitudinal axis and parallel relative to the second centrally registered longitudinal axis; wherein opposed axial ends of said third peripheral edge are abutted to said first peripheral edge and said second peripheral edge, respectively.

US Pat. No. 10,889,476

DEVICE AND METHOD FOR SECURING END OF BRAIDED HOISTING ROPE TO LIFTING DEVICE

1. A device for securing an end of a braided hoisting rope to a lifting device, comprising:a tubular fastening frame to be fixed to the lifting device; and
a coil spring arranged to be installed and fastened over the tubular fastening frame;
wherein when an end of the hoisting rope is secured in place, a hollow, or workable into hollow, end of the hoisting rope is threaded over windings of the coil spring as an outer surface of the windings and into contact or to be brought into contact with a surface of the tubular fastening frame.

US Pat. No. 10,889,475

COMPACT WINCH

Woods Hole Oceanographic ...

1. A winch apparatus, comprising:a horizontal winch drum for storing cable comprising two axial ends and a flange on at least one axial end;
a disengagable motor assembly comprising a motor, a gearbox, and a housing;
a drive means comprising a drive shaft and a drum engagement means;
a bearings means;
a base; and
a motor assembly quick removal means to allow for the removal of the motor assembly without dismantling the entirety of the winch;wherein the drum engagement means is engaged with (i) an inner face of the winch drum and (ii) the housing; and the motor assembly quick removal means detaches the drum engagement means from the winch drum, allowing the drive means, the motor assembly and the housing to exit the winch drum;wherein at least the motor is centered within the housing, the housing is at least partially disposed within the winch drum with a gap between the outer face of the housing and the inner face of the winch drum, and the housing is connected to the base;the motor assembly is engaged with the winch drum by means of the drive means through at least one axial end of the winch drum;the bearing means supports the winch drum, and the bearing means is attached to an axial end of the winch drum and is attached to the base;the motor assembly may be disengaged from the winch drum using the quick removal means without dismantling the entirety of the winch;the winch is capable of hauling and supporting a heavy load on a cable; andthe motor is capable of controllably rotating the winch drum.

US Pat. No. 10,889,474

BATTERY CELL SHIFTING IN ROTATIONAL MOTOR APPLICATIONS

Hall Labs LLC, Provo, UT...

1. A device comprising:a battery pack comprising a plurality of batteries and a switch, the battery pack having an overall voltage;
the switch varies the overall voltage in discrete steps by changing the arrangement of the plurality of batteries, whether in series, in parallel, or in a combination thereof;
a motor comprising a shaft, wherein the battery pack powers the motor which drives the shaft at a rotational speed, and wherein the rotational speed varies proportionally with the overall voltage.

US Pat. No. 10,889,473

LOAD CRANE MAIN BOOM

Fassi Gru S.P.A., Albino...

1. A load crane main boom comprising:a tubular fixed first boom section, a tubular second boom section telescopically arranged and movable relative to the fixed first boom section between a retracted position and an extended position to define a moveable second boom section, and at least a tubular third boom section telescopically arranged and movable relative to the movable second boom section between a retracted position and an extended position to define a third moveable boom section;
a hydraulic system comprising:
a first cylinder-piston group axially extending within the main boom, integrally connected with the fixed first boom section and connected to the movable second boom section so as to move the moveable second boom section relative to the fixed first boom section under the action of a pressurized working fluid;
a second cylinder-piston group axially extending within the main boom, integrally connected with the movable second boom section and connected to the movable third boom section so to move the movable third boom section relative to the movable second boom section under the action of said pressurized working fluid;
a first opening and a second opening at the first cylinder-piston group for at least one of injecting pressurized working fluid into the hydraulic system or discharging pressurized working fluid from the hydraulic system;
a first tube and a sixth tube hydraulically connecting the first and the second cylinder-piston groups, the first tube and the sixth tube at least partially extending near the second cylinder-piston group along the axial direction and connected to the second cylinder-piston group in such a manner so that the first tube and the sixth tube form respective bends,
wherein the main boom further comprises:
a transversal second main rod connected to the second boom section supporting the second cylinder-piston group, and
a second reinforcing plate connected to the second boom section, comprising:
a first and second opposite lateral portions internally fixed to the second boom section and comprising through holes where the second main rod is arranged, to form first and second reinforcing elements for the second boom section;
a central portion connecting said first and second lateral portions and the central portion comprising a raised section, a lowered section and a section connecting the raised section and the lowered section;
a third reinforcing element having a through hole where the second main rod is arranged, said third reinforcing element being arranged in an intermediate position between the first lateral portion and the second cylinder-piston group,
wherein on a first side of the central portion, the third reinforcing element is positioned in correspondence of the raised section and the second cylinder-piston group is positioned in correspondence of the lowered section, said bends of the first and sixth tubes being inclined towards the third reinforcing element, and
wherein on a second side of the central portion, the first cylinder-piston group is positioned in correspondence of the raised section.

US Pat. No. 10,889,472

AUTO LOCK CABLE LIFTER

1. An automatic locking mechanism for a clamping device comprising a rotatable element rotatably coupled to a body, the automatic locking mechanism comprisinga lockable element; and
a receptacle configured to be mated to the lockable element,
wherein one selected from a group consisting of the lockable element and the receptacle is coupled to the rotatable element, and the other selected from the group consisting of the lockable element and the receptacle is coupled to the body,
wherein the lockable element and the receptacle are configured to toggle the rotatable element of the clamping device by rotating the rotatable element in a first direction, followed by rotating the rotatable element in a second direction opposite the first direction,
wherein the toggling process toggles the rotatable element between a rotatable configuration and a non-rotatable configuration,
wherein in the rotatable configuration, the rotatable element is configured for further rotating in the second direction,
wherein in the non-rotatable configuration, the rotatable element configured for not rotating in the second direction,
wherein the receptacle comprises a zigzag path formed on a surface of the rotatable element,
wherein the lockable element comprises a rod element configured to fit in the zigzag path.

US Pat. No. 10,889,471

ESCALATOR WHICH CAN BE CONNECTED TO A LIFT

INVENTIO AG, Hergiswil (...

1. An escalator comprising:a first access zone arranged on a first level of a building;
a second access zone arranged on a second level of the building;
an inclined zone connecting the first and second access zones with one another; and
a structural frame comprising fastening points;
wherein components of an elevator can be connected to the fastening points of the structural frame such that the components of the elevator can be supported, at least partially, by the structural frame,
wherein the components of the elevator are arranged at a side of the escalator that is outside a conveyor zone of the escalator, at the fastening points of the structural frame,
wherein the elevator is located between the same levels as the escalator and connects these with one another, and
wherein the elevator comprises at least one guide rail and a platform that is moved in a guided manner on the guide rail.

US Pat. No. 10,889,470

AUTOMATIC ROPE TENSION EQUALIZER SYSTEM AND METHOD

thyssenkrupp Elevator Cor...

1. An automatic tension equalizer system, comprising:a hitch plate having first and second apertures, each said aperture having a cavity;
a first plunger at least partially situated in said cavity of said first aperture;
a second plunger at least partially situated in said cavity of said second aperture;
first and second cam assemblies respectively positioned at least partially within said first and second apertures, each said cam assembly having a cam and a rod extending therefrom, said cam of said first cam assembly engaging said first plunger, said cam of said second cam assembly engaging said second plunger;
a network connecting each said cavity to each other said cavity; and
fluid in said network automatically equalizing pressure on said first and second plungers, thereby affecting positioning of said first and second plungers and, through each said cam, tension on each said rod,
wherein excess tension on said rod of said first cam assembly causes, via interaction between said cam of said first cam assembly and said first plunger, said first plunger to further enter said cavity of said first aperture.

US Pat. No. 10,889,469

WOVEN ELEVATOR BELT WITH COATING

OTIS ELEVATOR COMPANY, F...

1. A belt for suspending and/or driving an elevator car, comprising:a plurality of tension elements extending longitudinally along a length of the belt;
a plurality of warp fibers and a plurality of weft fibers interlaced with the plurality of tension elements forming a composite belt structure; and
a coating at least partially covering the plurality of tension elements, the plurality of warp fibers and the plurality of weft fibers, the coating including:
a base coating material; and
at least one additive mixed with the base coating material to improve an operational characteristic of the belt;
wherein the additive includes one or more of alumina, silica, Mania, graphite, chopped fiber, melamine salts, zinc powder, graphene, talc, Al/Mg hydroxide, exfoliated clay platelets, carbon black, carbon nanotubes, or clay;
wherein the coating includes a first coating layer having a first viscosity and a second coating layer applied over the first coating layer, the second coating layer having a second viscosity greater than the first viscosity.

US Pat. No. 10,889,468

ELECTRONICS SAFETY ACTUATOR

OTIS ELEVATOR COMPANY, F...

1. A selectively operable braking device for an elevator system including a car and a guide rail, comprising:a safety brake disposed on the car and adapted to be wedged against the guide rail when moved from a non-braking state into a braking state;
an engagement mechanism having an engaging position and a nonengaging position, the engagement mechanism operably coupled to the safety brake and configured to move the safety brake between the non-braking state and braking state when the engagement mechanism moves between the nonengaging position and the engaging position; and
a first magnetic brake pad and a second magnetic brake pad, the first magnetic brake pad and the second magnetic brake pad disposed in opposing directions adjacent to the guide rail and configured to move between the non-engaging position and the engaging position, the first magnetic brake pad and the second magnetic brake pad operably coupled to the engagement mechanism, wherein the engagement mechanism is configured such that movement of the first magnetic brake pad into the engaging position causes movement of the second magnetic brake pad into the engaging position, the first magnetic brake pad and the second magnetic brake pad being magnetically attracted to the guide rail in the engaging position.

US Pat. No. 10,889,467

SYNCHRONIZATION BASED ON DISTANCE OF MAGNET ASSEMBLY TO RAIL

OTIS ELEVATOR COMPANY, F...

1. An elevator system, comprising:at least one guide rail;
a plurality of safeties to respectively selectively impede or permit movement of an elevator car along a corresponding guide rail;
first and second electronic safety actuators (ESAs) respectively coupled to at least one corresponding safety,
the first ESA comprising a first braking surface located a first distance from the corresponding guide rail,
the second ESA comprising a second braking surface located a second distance from the corresponding guide rail, and
the first and second braking surfaces deployable across the first and second distances, respectively, to contact the corresponding guide rails;
a sensing system to determine the first and second distances; and
a control system to deploy the first and second braking surfaces toward the corresponding guide rails in response to an over-speed or an over-acceleration condition with synchronization based at least in part on the first and second distances.

US Pat. No. 10,889,466

ELEVATOR LANDING DOOR LOCK SAFETY SYSTEM

OTIS ELEVATOR COMPANY, F...

1. An access prevention system of an elevator landing door lock comprising:a landing door lintel for a landing door of an elevator system;
a lock mechanism mounted to the lintel and arranged to enable unlocking of the elevator landing door; and
an indicator feature on the lintel and aligned with the lock mechanism to indicate a location of a blocked locking mechanism, wherein the indicator feature is at least one of frangible or breakable to permit access to the lock mechanism when the indicator feature is broken.

US Pat. No. 10,889,465

MECHANICAL HOISTWAY ACCESS CONTROL DEVICE

OTIS ELEVATOR COMPANY, F...

1. A mechanical hoistway access control device for an elevator landing door, comprising:a first and a second base plates mounted on the hoistway side of a landing door panel and arranged in parallel with each other;
a slider slidably arranged between the first and second base plates, the slider configured to move in conjunction with a car door and configured to protrude out from a door closing side end of the landing door by a first elastic member to take an extended position when the landing door is opened with no elevator car at the landing; and
a latch attached to the landing door and configured to engage with the slider to keep the slider in the extended position once the slider protrudes out from the door closing side end of the landing door, the slider kept in the extended position by the latch upon moving the landing door in a closing direction.

US Pat. No. 10,889,464

SYSTEM FOR THE GENERATION OF CALL ADVANCE DATA

KONE CORPORATION, Helsin...

1. A system for generation of call advance data for an elevator control, wherein said system is configured to be installed in an elevator car moving in an elevator shaft and comprises:at least one acceleration sensor outputting current acceleration data and/or magnetometer outputting a magnetic flux signal which comprises current magnetic flux data at a current position of the elevator car, said at least one acceleration sensor and/or magnetometer is mounted in connection with the elevator car;
a velocity calculating unit which calculates from the current acceleration/magnetic flux data or from current car position data current car velocity data;
a position calculating unit which calculates from the current acceleration/magnetic flux data and/or from the current car velocity data current car position data;
a call advance processing unit which calculates from the current car velocity data and the current car position data call advance data which designates a time until which the car is able to stop at a next approaching floor in travelling direction, which call advance data is transmitted to a call allocation unit of an elevator control;
a memory for storing at least one acceleration profile establishing an acceleration vs. time for different routes of the elevator car in the shaft,
wherein the acceleration sensor and/or magnetometer, the velocity calculating unit, the position calculating unit, the call advance processing unit and the memory are located in a sensor unit mounted to the elevator car, and the sensor unit further comprises a first wireless data transmission link co-acting with a second wireless transmission link which is connected with the elevator control, such that the call advance data is transmitted to the call allocation unit of the elevator control through the first and second wireless transmission links,
wherein the sensor unit further comprises an accumulator for supplying power to all the components in the sensor unit.

US Pat. No. 10,889,463

METHOD AND SYSTEM FOR INDOOR WAYFINDING BASED ON ELEVATOR INFORMATION

OTIS ELEVATOR COMPANY, F...

1. A method, comprising:generating, by a processor, an elevator call to an elevator upon a detection by a proximity system of a user device within a predetermined distance to the elevator;
generating, by the processor, a map on the user device in response to detection of the user device, the map corresponding to a source floor;
receiving, by a processor, the elevator call that indicates a source floor and a destination;
processing, by the processor, the destination to derive a target floor;
causing, by the processor, an elevator to travel between the source floor and the target floor; and
performing, by the processor, at least one of a plurality of wayfinding operations upon arrival of the elevator at the target floor, wherein the at least one of the plurality of wayfinding operations upon arrival of the elevator at the target floor includes updating the map to correspond to the target floor.

US Pat. No. 10,889,462

CABLE REEL FOR EXCAVATOR

1. A cable reel for an electric excavator, comprising:an outer frame and a reel assembly installed on the outer frame;
wherein the reel assembly is connected with a wiring device assembly; the wiring device assembly comprises a speed reducer;
the reel assembly comprises a left reel and a right reel; an inner bracket is arranged in the outer frame; the inner bracket comprises a left bracket and a right bracket which are respectively connected with the left reel and the right reel; and a telescopic cylinder for controlling the left bracket and the right bracket to swing is arranged between the left bracket and the right bracket;
a cross section of the left reel is a semicircular cambered surface; a tripod is fixed to an inner wall of the left reel; the tripod comprises a supporting rack and a cross beam; a cross section of the right reel is provided with an open circular cambered surface; and the outer wall of the right reel is matched with the inner wall of the left reel; and
a motor is installed on the speed reducer; and the motor is linearly connected with the telescopic cylinder and controls an expansion and contraction of the telescopic cylinder.

US Pat. No. 10,889,461

EXPANDABLE COIL DEPLOYMENT SYSTEM FOR DRUM ASSEMBLY AND METHOD OF USING SAME

Trinity Bay Equipment Hol...

1. A deployment trailer comprising:a first support bracket configured to interlockingly and rotatably receive a first shaft end of a drum;
a second support bracket configured to interlockingly and rotatably receive a second shaft end shaft of the drum that is opposite the first shaft end;
a horizontal support assembly comprising a female telescoping bar and a male telescoping bar, wherein the male telescoping bar is configured to move within the female telescoping bar to enable width of the deployment trailer to be adjusted at least in part by causing the male telescoping bar and the female telescoping bar to move relative to one another;
a first support arm connected between the horizontal support assembly and the first support bracket, wherein the first support arm is pivotably connected to the first support bracket;
a second support arm connected between the horizontal support assembly and the second support bracket, wherein the second support arm is pivotably connected to the second support bracket; and
a third support arm pivotably connected to the first support bracket, wherein:
the first support arm is a lower support arm;
the third support arm is an upper support arm; and
the deployment trailer is configured to:
enable the lower support arm and the upper support arm to be pivoted toward one another to facilitate transitioning the deployment trailer toward a collapsed position; and
enable the lower support arm and the upper support arm to be pivoted away from one another to facilitate transitioning the deployment trailer away from the collapsed position.

US Pat. No. 10,889,460

MATERIAL HANDLING DEVICE

1. An apparatus for retaining a utility spool on a horizontal shaft, said apparatus comprising: a first rotational collar and a second rotational collar configured to be attached to the horizontal shaft on either side of the utility spool to allow rotation of the utility spool independent of the shaft, wherein each of the two rotational collars contain:a) a first sleeve comprising an inner surface and an outer surface of cylindrical geometry, the first sleeve having:
1) an inner diameter,
2) a first outer diameter, and
3) a second outer diameter,
the first outer diameter located on a first end of the sleeve and the second outer diameter located on a second end of the sleeve, the second end indicated by an external flange extending out of the profile and at least one hole through the flange for securing a fastener through the flange and to the horizontal shaft:
b) a second frusto-conical sleeve; overlaying and partially surrounding the first sleeve;
1) a first outer diameter on a first end of the second sleeve,
2) a second outer diameter on a second end of the second sleeve;
wherein the first sleeve and second frusto-conical sleeve make contact with one another and form a cylindrical lubricious surface;
wherein the second end of the second sleeve abuts to the external flange on the first sleeve and the external flange prevents horizontal movement of the second sleeve relative to the first sleeve, the outer surface of the first sleeve forming a cylindrical lubricious surface with the inner surface of the second sleeve, the lubricious surface extending along the majority of the inner surface of the second sleeve, such that the second sleeve freely rotates relative to the first sleeve around the lubricious surface, and containing a lip separating the frusto-conical outer surface from the second outer diameter;
wherein when installed the first rotational collar and the second rotational collar face opposite each other when positioned inside each side of the utility spool such that the second frusto-conical sleeves rotate freely relative to the first sleeves.

US Pat. No. 10,889,459

METHOD FOR PERFORATING A NONLINEAR LINE OF WEAKNESS

1. An apparatus for providing a nonlinear line of weakness on a web material, the apparatus comprising:a first roll comprising a base comprising at least one counter component having a length (LCC) wherein the counter component comprises a nonlinear shape having a shape width (W);
a second roll comprising a support operatively engaged with the base;
a blade having a length (LB) and being disposed on the support so as to cooperate in interacting relationship with the counter component, wherein the blade has a plurality of teeth;
a driving means associated with the second roll capable of oscillating the support for a distance (D) in a shifting direction in a predetermined movement profile, wherein the shifting direction is substantially parallel to a cross machine direction; and
wherein the first roll is not capable of oscillating for the distance (D) in the shifting direction in the predetermined movement profile with the second roll such that a different point on the blade interacts with a different point on the counter component.

US Pat. No. 10,889,458

METHOD FOR MANUFACTURING CORELESS PAPER ROLL

CORELEX SHIN-EI CO., LTD....

1. A method for manufacturing a coreless paper roll, the method comprising:a first step in which a tissue web is unrolled from a parent roll;
a second step in which adhesive is sprayed on the tissue web;
a third step in which the tissue web is wound on a winding mandrel to form a log roll; and
a fourth step in which the log roll is cut into round slices to form a plurality of paper rolls,
wherein the second step includes a fifth step in which a first adhesive, which has a bonding strength capable of solidifying the tissue web wound on the winding mandrel and capable of separating a sheet of tissue from the solidified tissue web, is deposited on a portion of the tissue web from which the tissue web starts to be wound on the winding mandrel, the portion including both ends in the width direction of the tissue web and positions at which the log roll is cut in the fourth step, and a sixth step in which a second adhesive having a lower bonding strength than the first adhesive is deposited on portions between the positions where the first adhesive is deposited.

US Pat. No. 10,889,457

SHEET CONVEYING APPARATUS

Brother Kogyo Kabushiki K...

1. A sheet conveying apparatus comprising:a conveying roller configured to convey a sheet in a conveying direction;
driven rollers arranged with intervals in a width direction intersecting with the conveying direction, the driven rollers being opposed to the conveying roller in a direction perpendicular to the conveying direction and the width direction; and
coil springs provided corresponding to the driven rollers respectively and serving as rotating shafts for rotatably supporting the driven rollers,
wherein the coil springs include a right-handed twining coil spring and a left-handed twining coil spring, and
wherein each of the driven rollers is rotatably supported by only one coil spring which is included in the coil springs and which is one of the right-handed twining coil spring and the left-handed twining coil spring.

US Pat. No. 10,889,456

HANDLING SYSTEM FOR HANDLING STACKABLE FLAT ELEMENTS

BOBST GRENCHEN AG, Grenc...

1. A handling system for handling a stack of flat elements, the handling system comprising:a supporting table comprising a supporting surface configured to support at least a first edge portion of the stack;
a clamping device located and configured for clamping a first part of the stack to the supporting table; and
a lifting device configured to lift a second part of the stack from the supporting table;
wherein the first part is adjacent the first edge portion, and the second part is adjacent a third edge portion of the stack, the third edge portion being transverse to the first edge portion;
the lifting device and the clamping device are arranged at the supporting table such that the stack is bendable by clamping of the first part of the stack onto the supporting table by the clamping device and by lifting the second part of the stack from the supporting table by the lifting device at a same time, such that the stack is bent around a bending axis so that the third edge portion is lifted relative to the first edge portion;
the bending axis extends within a plane parallel to a supporting plane of the supporting surface;
a transport device comprising a supporting platform configured to support at least a second edge portion of the stack transverse to the third edge portion, the transport device is configured to clamp the second edge portion of the stack to the supporting platform;
the transport device is configured to be moved to transport the stack to the supporting table, such that the first edge portion of the stack is positioned on the supporting table,
the lifting device comprises a first lifting element configured to move along a lifting direction having at least one vertical component for lifting a part of the stack, and
the first lifting element is mounted to the supporting table such that the first lifting element is extendible from the supporting surface of the supporting table on which the stack is arrangeable.

US Pat. No. 10,889,455

GRAIN SPREADING DEVICE

Agnew Steel, Inc., Moffi...

1. A grain-spreading device, comprising:a flow-control ring adapted to be positioned below a grain bin opening, the flow-control ring comprising an upper opening and a bottom; and
a cone movably suspended below the flow-control ring by a plurality of springs to create a variable opening between the cone and the bottom of the flow-control ring, the plurality of springs creating a restoring force;
wherein the variable opening increases in size when a weight of grain on the cone moves the cone away from the bottom of the flow-control ring against the restoring force of the plurality of springs;
wherein each spring of the plurality of springs is connected between an ear proximate the upper opening of the flow-control ring and a mounting point on the cone;
wherein the cone comprises a plurality of channels and a plurality of peaks between the channels, each channel comprising an upper surface, wherein the variable opening comprises a plurality of gaps between the bottom of the flow-control ring and the upper surfaces of the channels; and
wherein each mounting point is proximate to one of the plurality of peaks.

US Pat. No. 10,889,454

DIVERTER ASSEMBLY FOR A PNEUMATIC TRANSPORT SYSTEM

FrieslandCampina Nederlan...

1. A diverter assembly which pneumatically transports a substance with bulk material using a fluid flow, comprisinga diverter main body provided with an input pipe connection having an input flow direction, and at least one output pipe connection having an output flow direction perpendicular to the input flow direction, wherein the diverter main body further comprises
a collision wall part arranged remote and opposite from the input pipe connection and having a substantially rigid collision surface arranged perpendicular to the input flow direction,
a narrowing flow part shaped and arranged to provide a flow path from the collision wall part to the at least one output pipe connection,
wherein the diverter main body further comprises a curved wall part extending between the collision wall part and the input pipe connection, and
wherein the curved wall part, narrowing flow part and collision wall part form a fluid tight enclosure between the input pipe connection and the at least one output pipe connection.

US Pat. No. 10,889,453

TRANSFER WHEEL AND METHOD FOR TRANSFERRING OBJECTS

Philip Morris Products S....

1. A method for transferring capsules comprising an in-line adaption of a radial position of a capsule in a seat of a transfer wheel, comprising:providing a transfer wheel comprising a seat for receiving and accommodating a capsule;
receiving a first capsule on the seat in a receiving location, the first capsule having a first size;
transferring the first capsule to a transfer location and releasing the first capsule at the transfer location;
receiving a second capsule on the seat in the receiving location, the second capsule having a second size, the second size being different to the first size; and
adapting the radial position of the seat such that a maximum radial extension of the transfer wheel defined by an outermost extension of the capsule on the seat is the same for each of the first or second capsule accommodated on the seat in at least one of the receiving location or the transfer location; therein adapting the position of the seat by compressing or expanding a resilient seat module comprising the seat, thereby compressing the seat module itself or pushing back the seat module by compressing a module support;
wherein, the transfer wheel comprises at least a seat module, the seat module comprising a seat located at the peripheral face of the transfer wheel and adapted for accommodating a capsule on the seat, wherein the at least one seat module is an elastically mounted resilient seat module or an elastically compressible resilient seat module, wherein a position of the seat of the seat module is adaptable in radial direction of the transfer wheel, and wherein the seat is a cup-shaped recess in the seat module.

US Pat. No. 10,889,452

ARTICLE ACCUMULATION AND ARTICLE GROUP FORMATION

Douglas Machine Inc., Al...

1. An article processing station wherein article groups are formed and article groups discharged, the article processing station comprising:a. an accumulating article shaft having an ingress portion and an egress portion, said accumulating article shaft comprising a grouped article receiving deck delimiting a shaft floor within said egress portion of said accumulating article shaft, opposingly paired sidewalls extending in a process flow direction and spanning said ingress and egress portions of said accumulating article shaft, and an end wall extending in a direction transverse to process flow and downstream of said opposingly paired sidewalls and spanning said ingress and egress portions of said accumulating article shaft, said grouped article receiving deck comprising spaced apart deck fingers extending in a process flow direction, said end wall comprising spaced apart wall fingers; and,
b. a robotic end of arm tool comprising spaced apart tool fingers, said spaced apart tool fingers registerable in relation to spaces of said spaced apart end wall fingers and spaces of said spaced apart deck fingers so as to thereby pass through said end wall and said grouped article deck respectively, said robotic end of arm tool animated for travel to, through and from said accumulating article shaft, said robotic end of arm tool receiving articles entering said ingress portion of said accumulating article shaft while traveling from said ingress portion towards said egress portion in furtherance of depositing an article group upon said grouped article receiving deck during travel from said accumulating article shaft.

US Pat. No. 10,889,451

SYSTEM AND METHOD FOR CONTROLLING AN ACCUMULATION CONVEYOR

Intelligrated Headquarter...

10. A material handling system, comprising:an accumulation conveyor comprising:
a plurality of zones comprising at least a first zone, a second zone, and a third zone, wherein the first zone is upstream of the second zone, wherein the second zone is upstream of the third zone; a plurality of sensors, comprising at least a first sensor, a second sensor, and a third sensor; wherein the first sensor is located at an exit portion of the first zone, the second sensor is located at an exit portion of the second zone, and the third sensor is located at an exit portion of the third zone; and
a plurality of control modules comprising at least a first control module, a second control module, and a third control module, wherein the first control module is communicably coupled with the first sensor, the first zone, and second control module, wherein the second control module is communicably coupled with the second sensor, the second zone, and third control module, wherein the third control module is communicably, coupled with the third sensor and the third zone,
wherein the second control module is configured to:
receive a third feedback signal from the third control module, wherein the third feedback signal indicates that the third sensor in the third zone is blocked;
set a second drive assembly associated with the second zone to a disengaged state;
receive a first signal from the first control module associated with the first zone, wherein the first signal indicates whether a first article has an irregular boundary or a second article has a regular boundary exits from the first zone;
control the second drive assembly and a second brake assembly associated with the second zone based on the indication of the exit of the one of the first article or the second article from the first zone by the first signal received from the first control module, wherein the second drive assembly and the second brake assembly perform a first set of operations for the first article and a second set of operations for the second article; and
a main controller communicably coupled with the accumulation conveyor to perform operations to receive data indicating conditions for each zone of the plurality of zones.

US Pat. No. 10,889,450

DEVICE FOR ALIGNING A NUMBER OF PACKAGES

1. A method for aligning a number of irregular tetrahedral packages in a conveyor system comprising at least one bottom belt, the method comprising:receiving irregular tetrahedral packages at a first end portion of the at least one bottom belt;
aligning the packages with at least an intermediate portion of the at least one bottom belt, the intermediate portion being declined against a support surface of the conveyor system such that during transporting, the packages conveyed by the at least one bottom belt in the intermediate portion move laterally towards the support surface for alignment thereto due to the declined intermediate portion and by means of gravity, wherein the aligned packages comprise a first type aligned with respect to the support surface in a first lateral position and a second type aligned with respect to the support surface in a second lateral position;
providing an elongated guide member downstream a second end portion of the at least one bottom belt, said elongated guide member being laterally positioned in relation to the at least one bottom belt, wherein the elongated guide member comprises a width extending at least between a first longitudinal line intersecting a first center of mass of the first type of the packages in the first lateral position and a second longitudinal line intersecting a second center of mass of the second type of the packages in the second lateral position; and
operating the at least one bottom belt to transport said packages onto the elongated guide member such that the first type of the packages aligned in the first lateral position slide and tilt over a first side of the elongated guide member and the second type of the packages aligned in the second lateral position slide and tilt over a second side of the elongated guide member, the second side of the elongated guide member being opposite the first side of the elongated guide member;
wherein the first and second types of the packages are aligned in the first and second lateral positions such that forward sealed edges of the first and second types of the packages lay in a flat position on a top surface of the at least one bottom belt;
wherein a first conveyor belt is provided along the first side of the elongated guide member and a second conveyor belt is provided along the second side of the elongated guide member;
wherein the first and second conveyor belts are tilted relative to the elongated guide member to form pockets for catching and conveying the first and second types of the packages such that the forward sealed edges of the first and second types of the packages are tilted to a standing position; and
wherein the first conveyor belt and the second conveyor belt are driven at different speeds to allow the first and second types of the packages to exit said first and second conveyor belts alongside each other for transporting the first and second types of the packages to downstream equipment.

US Pat. No. 10,889,449

TRANSPORT SYSTEM AND MANUFACTURING METHOD OF ARTICLE

CANON KABUSHIKI KAISHA, ...

1. A transport system comprising:at least one transport module forming a transport path on which a carriage that transports a workpiece travels;
a control unit that controls a position of the carriage on the at least one transport module based on a drive instruction; and
a state detection unit that detects a position of the carriage and a position of the workpiece on the carriage,
wherein the control unit controls a stop position of the carriage based on the position of the carriage and the position of the workpiece on the carriage detected by the state detection unit.

US Pat. No. 10,889,448

SYSTEMS AND METHODS FOR CHAIN WEAR ELONGATION MEASUREMENT AND DRIVE COMPENSATION

John Bean Technologies Co...

1. A spiral conveyor belt system, comprising:a spiral conveyor belt;
inner and outer drive chains driving the spiral conveyor belt, the inner and outer drive chains each including a plurality of links arranged in a continuous loop, the inner drive chain having inner chain first measurements for plurality of links and total chain length and the outer chain having outer chain first measurements for plurality of links and total chain length, wherein the inner and outer drive chains have different first measurement values and wherein the inner and outer drive chains are configured to run at different speeds having a first speed ratio; and
a chain elongation measurement system for counting the plurality of links of the inner and outer drive chains and for determining total chain length to determine inner and outer chain elongated measurements.

US Pat. No. 10,889,447

CONVEYOR AND CONVEYOR SYSTEM

AVANCON SA, Riazzino (CH...

1. A conveyor comprisinga first profile unit (1) extending in a conveying direction (L) and a second profile unit (2) extending in the conveying direction (L), the first profile unit (1) and the second profile unit (2) being arranged parallel to each other and being fixed to each other by means of at least one profile crossbeam (3), wherein the first profile unit (1) comprises a support profile (10) and a side profile (11) that can be releasably connected to each other to form a composed structure (10, 11) whose cross-section comprises a first lateral opening (12) and wherein the second profile unit (2) comprises a support profile (20) and a side profile (21) that can be releasably connected to each other to form a composed structure (20, 21) whose cross-section comprises a second lateral opening (22), wherein the first lateral opening (12) faces the second lateral opening (22),
at least one conveyor unit (4) that can be arranged between the first profile unit (1) and the second profile unit (2), wherein each conveyor unit (4) comprises a first side wall (40) and a second side wall (41), the first side wall (40) and the second side wall (41) being arranged parallel to each other, and wherein conveying elements (44, 45) are arranged between the side walls (40, 41),
wherein
the first side wall (40) can be releasably arranged in the first lateral opening (12) to form a composed structure (10, 11, 40) with a closed cross-section along the first side wall (40) wherein
the second side wall (41) can be releasably arranged in the second lateral opening (22) to form a composed structure (20, 21, 41) with a closed cross-section along the second side wall (41), characterized in that
a first connecting element (100, 200) of each support profile (10, 20) forms a first positive locking with a second connecting element (401, 411) of the corresponding side wall (40, 41),
a second connecting element (111, 211) of each side profile (11, 21) forms a second positive locking with a first connecting element (400, 410) of the corresponding side wall (40, 41), and
a second connecting element (101, 201) of each support profile (10, 20) forms a third positive locking with a first connecting element (110, 210) of the corresponding side profile (11, 21).

US Pat. No. 10,889,446

TUBULAR CABLE CONVEYOR SLUG WITH INTEGRATED CONNECTOR

FLEXICON CORPORATION, Be...

1. A drag conveyor assembly comprising:a traction element;
a plurality of slugs fixedly attached to the traction element, each slug of the plurality of slugs includes a pair of flanges with a cutting groove arranged therebetween;
a pair of ferrules that connect each slug of the plurality of slugs to the traction element, each slug of the plurality of slugs being overmolded onto a respective pair of the ferrules, such that when a first slug of the plurality of slugs is split to define two split slug sections, each split slug section remains fixedly attached to the traction element; and
a disk attached to each slug of the plurality of slugs.

US Pat. No. 10,889,445

EXTENDED LIFE CONVEYOR CHAIN TROLLEY AND METHOD

Frost Tech LLC, Grand Ra...

1. A conveyor chain wheeled chain member comprising: a wheeled chain member which includes a non-rotating wheel axle projecting therefrom; a load bearing wheel mounted on said non-rotating wheel axle, said load bearing wheel including a wheel inner member non-rotatably mounted on said non-rotating wheel axle, and including a wheel outer member rotatably mounted on said inner member; one of said wheeled chain member and said wheel inner member including a detent projecting therefrom and the other including a detent receiver into which said detent projects; whereby said load bearing wheel inner member is locked against rotation with respect to said wheeled chain member.

US Pat. No. 10,889,444

WORK-SAVING IMPROVEMENTS FOR FOOD-PROCESS LINES

13. A selected food process line machine for situating before immediately adjacent upline food process line apparatus and immediately downline food process line apparatus, said selected food process line machine comprising:an endless conveyor belt having an upper, food-product carrying run and a lower, return run, the upper, food-product carrying run extending between one nose end defining either an intake end or a discharge end bridging to either the immediately adjacent upline food process line apparatus or the immediately adjacent downline food process line apparatus, and, a spaced away other nose end;
a turret comprising a body supporting a movably mounted assembly for holding out the one nose end relative to the body, and, a spaced away inboard mount for the other nose end;
wherein the movably mounted assembly is movable between a first position and a second position wherein the first position has the one nose end aligned such that the upper, food-product carrying run successfully bridging to the respectfully immediately adjacent food process line apparatus for food product transfer therebetween; and
further comprising a carriage with pivot hardware pivotally propping the turret above the carriage;
wherein the second position has the one end nose end aligned apart from the respectively immediately adjacent food process line apparatus such that the selected food process line machine can pivoted with free clearance of the one nose end and upper, food-product carrying run from the immediately adjacent food process line apparatus to thereby give better access to all of said selected food process line machine, said immediately upline food process line apparatus and said immediately downline food process line apparatus for at least of one washing and maintenance operations; and
wherein said movably mounted assembly further comprising a pair of movable brackets for supporting the one nose end;
said movable brackets having extension and retraction strokes that correspondingly give the other nose end the first position and the second position.

US Pat. No. 10,889,443

POCKET-TYPE CONVEYOR BELT INSTALLATION

ContiTech Transportbandsy...

1. A pocket-type conveyor belt installation comprising:a plurality of carrying rollers designed to support a pocket-type conveyor belt, wherein the pocket-type conveyer belt includes a lower conveyor belt edge;
a plurality of carrying roller holders designed to connect the plurality of carrying rollers to a carrying frame;
wherein a carrying roller holder of the plurality of carrying roller holders includes a sensor element designed to record at least a force and/or a change in force; and
wherein the sensor element is further designed to record a temperature at the location of the carrying roller holder.

US Pat. No. 10,889,442

LADDER ROLLER AND TRANSPORT DEVICE

1. A ladder transport device for moving a ladder, said devise comprising:a ladder handle having a hollow crossmember and being capable of being detachably mounted on a ladder;
a body removably securable to the ladder handle, the body having a length and a width;
a pair of wheels secured to the body and rotatable relative to the body;
an axle;
a first wheel of the pair of wheels mounted on a first end of the axle;
a second wheel of the pair of wheels mounted on a second end of the axle; and
a plurality of rib structures extending from the body;
wherein a portion of the body of the transport device is captured within the hollow crossmember of the detachable ladder handle and the axle is captured between the rib structures and the axle is capable of rotating.

US Pat. No. 10,889,441

MOBILE DRIVE UNIT HAVING A CONVEYOR MODULE

Amazon Technologies, Inc....

1. A mobile drive unit comprising:a first chassis unit including a first wheel mounted on a first chassis base;
a second chassis unit including a second wheel mounted on the second chassis base;
a pivotal connection between the first chassis base and the second chassis base;
a first support structure pivotally mounted on the first chassis base;
a second support structure mounted on the second chassis base;
a payload housing pivotally mounted on the first support structure and the second support structure; and
a payload detection sensor mounted on the payload housing.

US Pat. No. 10,889,440

SYSTEM FOR TRANSFERRING ARTICLES FROM A CONTAINER

United States Postal Serv...

1. A tray content transfer system comprising:a frame configured to rotate about a rotation axis between an upright orientation and a rotated orientation;
a first retainer coupled to the frame and configured to secure a first tray within the tray content transfer system, the first tray containing one or more items;
a second retainer coupled to the frame and configured to secure a second tray within the tray content transfer system at a location spaced from the first tray along a longitudinal axis parallel to the rotation axis;
a paddle assembly movably coupled to the frame, the paddle assembly comprising a plurality of paddles, wherein the distance between the paddles is adjustable to selectively engage and release items at least partially disposed between the paddles, and wherein the paddle assembly is movable relative to the frame along a first linear axis parallel to the longitudinal axis and a second linear axis perpendicular to the first linear axis; and
a plurality of motors configured to adjust the distance between the paddles, to move the paddle assembly along the first linear axis and the second linear axis, and to rotate the frame about the rotation axis, in a predetermined sequence to transfer the one or more items from the first tray to the second tray.

US Pat. No. 10,889,439

SYSTEM FORMED BY SHELVING UNIT AND CORRESPONDING TELESCOPIC LOAD RECEIVING MEANS WITHOUT WIDTH ADJUSTMENT

1. A rack device for storing and retrieving storage goods in and from rack compartments, wherein the storage and retrieval is performed automatically by way of a storage and retrieval device, wherein the storage and retrieval device comprises a load-handling device having two gripping arms that are arranged distanced to each other in a longitudinal direction, wherein the two gripping arms are moveable in a depth direction of the rack compartments and each comprises a gripping device which allows the storage goods to be moved, in an active position of the respective gripping devices, along the depth direction into the rack compartments and to be removed from the rack compartments, wherein the two gripping arms each comprises a first guiding device, wherein the rack device comprises:a plurality of rack compartments, wherein each of the rack compartments comprises a shelf and at least two depth supports extending along the depth direction and being arranged distanced to each other in a longitudinal direction of the rack compartments, thereby defining a storage location therebetween;
wherein each of the depth supports comprises a second guiding device, which extends in the depth direction and which is configured to cooperate with the respective first guiding devices of the two gripping arms such that the gripping arms, during storage or retrieval, are in contact with the respective depth supports via the respective guiding devices and are guided in the depth direction in a moveable manner along the respective depth supports, wherein each of the depth supports projects from the shelf of the rack compartment in a height direction for keeping the storage goods laterally within the storage location.

US Pat. No. 10,889,438

STOCKER

MURATA MACHINERY, LTD., ...

1. A stocker comprising:a wall that separates an inside and an outside of the stocker;
a storage area on an inner side of the wall to store articles;
a duct on a wall side of the storage area and extending in a vertical direction;
an inlet at an upper end of the duct to introduce air flowing downward into the duct;
a flow regulator including a partitioning plate to at least partially separate an upper side and a lower side of the duct and to regulate an airflow between the upper side and the lower side of the duct;
blowout openings on a storage area side of the duct to blow out air to the storage area; and
a fan on a lower side of the flow regulator of the duct to draw in outside air directly from the outside of the stocker and to introduce the outside air into the duct.

US Pat. No. 10,889,437

REFUSE RECEPTACLE WITH STABLE REMOVABLE LID AND RETAINER

Print Cottage LLC, Accom...

1. A removable retainer with a lid on a garbage can comprising, in combination:said garbage can having a top opening surrounded by a first skirt with a smooth curved surface adjacent an upper edge thereof;
said lid comprising a cover portion having a downwardly extending second skirt with a smooth curved surface, descending from a peripheral edge thereof overlapping said first skirt when said lid is removably in place covering said top opening;
said cover portion having a handle comprising a raised central rib extending in a direction from one side of said lid to an opposite side of said lid; and,
said central rib having opposite handle tabs formed therein along at least a portion of the length of said central rib,
in which a groove is formed on each of opposite sides of upper edges of said smooth surfaced garbage can skirt, and a boss is mounted inside of said garbage can lid on each of opposite sides thereof, said grooves each receiving one of said bosses when said smooth surfaced skirt of said lid is placed over the top opening of said garbage can for locking said lid to said garbage can,
said combination further comprising a bungee cord extending between opposite sides of said garbage can over said lid nested in a concave groove extending axially lengthwise within said raised rib of said lid for securing said lid on said garbage can against intrusion by animals, while allowing a user to remove said lid for emptying said garbage can, without said lid being pivotably attached and avoiding the lid from striking the user as the user is lifting the garbage can and dumping the contents therefrom.

US Pat. No. 10,889,436

DISTRIBUTED MONITORING SYSTEM AND WASTE MANAGEMENT SYSTEM AND METHOD

Xorro Pty Ltd, Mt Hawtho...

1. A detector for a rubbish receiving bin comprising:a first sensor positioned so as to sense the level of rubbish in the bin and for creating a first signal representing the sensed rubbish level in the bin;
a processor configured to receive the first signal and determine the level of rubbish in the bin based on the received first signal as one of at least three representations, at least two of which are discrete representations of the level of rubbish in the bin and another of which is a representation of no rubbish in the bin;
a second sensor positioned so as to sense an identifier device of a waste collector when the identifier device is proximate to the bin, wherein the second sensor decodes an encoded identifier of the waste collector and creates a second signal representing the presence or absence of the waste collector being proximate to the bin;
a processor configured to receive the second signal and determine waste collector attendance at the bin;
an output transmitter configured to transmit a third signal to a waste management system encoding an identifier of the bin, any attendance at the bin by the waste collector and the representation of the level of rubbish in the bin, wherein the output transmitter is also configured to transmit a fourth signal to a mobile device for indicating to the waste collector either the level of rubbish in the bin or that the bin needs to be emptied.

US Pat. No. 10,889,435

LEAF COLLECTION APPARATUS

1. A debris collecting hoop comprising:a center scoop located between and connected to a first extension and a second extension via hinges, said center scoop defining a leading scoop edge and a trailing scoop edge separated by a scoop width,
said trailing scoop edge is in-line with a first extension trailing edge of said first extension and a second extension trailing edge of said second extension;
at least a substantial portion of a first leading edge consisting of a first linear edge that is parallel to said first extension trailing edge with a first width that is narrower than said scoop width, said first extension comprising said first leading edge;
at least a substantial portion of a second leading edge consisting of a second linear edge that is parallel to said second extension trailing edge with a second width that is narrower than said scoop width, said second extension comprising said second leading edge;
said first extension including a first fastener configured to mate with a second fastener to attach said first extension to said second extension forming said debris collecting hoop, said debris collecting hoop configured to be received by an open end of a plastic bag, said plastic bag defined by said open end and a closed end, said debris collecting hoop never covering said bag closed end; and
said first extension and said second extension each possessing at least one pinch connector half that is configured to connect to an opposing pinch connector half in a mating relationship with a portion of a plastic bag interposed between said at least one pinch connector half and said opposing pinch connector half;
said first extension comprises a gusset with a first edge directly attached to said first linear edge and a second edge directly attached to said center scoop, a scoop-extension interface edge of said first extension is defined by the distance between said first extension trailing edge to where said gusset meets said leading scoop edge.

US Pat. No. 10,889,434

ATTACHABLE BAG DISPENSER

1. A receptacle-liner dispenser for dispensing disposable liners, the dispenser comprising:a liner holder including:
one or more walls defining an interior configured for storing the liners; and
a dispensing region configured for providing a passageway between the interior and an exterior of the holder; and
one or more tabs projecting exteriorly from the holder, the tabs configured to perform a releasable securing of the dispenser to a surface;
wherein:
a first wall defining the interior includes the dispensing region; and
the tabs project from a second wall, the second wall opposite the first wall; and
in an unassembled state:
assembly of the dispenser comprises folding the dispenser along one or more creases; and
the tabs are configured to be releasably held in place by two side closure flaps.

US Pat. No. 10,889,433

CASSETTE AND APPARATUS FOR PACKING DISPOSABLE OBJECTS INTO AN ELONGATED TUBE OF FLEXIBLE MATERIAL

INTERNATIONAL REFILLS COM...

1. A cassette for packing at least one disposable object, comprising:an annular receptacle including an annular wall delimiting a central opening of the annular receptacle, and a volume configured to receive an elongated tube of flexible material radially outward of the annular wall;
a length of the elongated tube of flexible material disposed in an accumulated condition in the volume of the annular receptacle; and
an annular opening at an upper end of the cassette for dispensing the elongated tube such that the elongated tube extends through the central opening of the annular receptacle to receive disposable objects in an end of the elongated tube, wherein the annular receptacle includes a chamfer in a bottom portion of the central opening, the chamfer extending continuously from the annular wall and radially outward of a downward projection of the annular wall, the chamfer delimiting a portion of the volume having a reduced width relative to a portion of the volume above the chamfer.

US Pat. No. 10,889,432

TRASH BAG ASSEMBLY FOR SMART TRASH RECEPTACLE, TRASH BAG FITTING DEVICE AND SMART TRASH RECEPTACLE

SHANGHAI TOWNEW INTELLIGE...

1. A trash bag assembly for a trash receptacle, comprising:a trash bag (4) that is a tubular structure having
a continuous internal lumen extending throughout an entire length thereof, and
two ends, one of which is open and the other of which is closed;
a storage body (1) defining both a first opening allowing the passage of trash and an annular trough (3) extending externally around the first opening and configured to receive the trash bag (4), the annular trough (3) having an open end; and
a lid (2) defining a second opening corresponding to the first opening, the lid (2) being configured to cover the open end of the annular trough (3) so as to form, together with one side wall of the annular trough (3), a gap serving as a bag exit, wherein
the annular trough (3) has an inner side wall proximate the first opening and an outer side wall away from the first opening, and
the lid (2) has an inner edge and an outer edge, the outer edge being pivotably connected at one end thereof to the outer side wall of the annular trough (3).

US Pat. No. 10,889,430

ENVIRONMENTAL CONTAINMENT DEVICE

1. An environmental containment device, comprising:a baseplate extending a longitudinal length and two ends disposed at opposing ends of the longitudinal length, the baseplate having two longitudinal edges extending along the longitudinal length and two lateral edges extending along a lateral width of the baseplate;
a flexible sidewall extending along at least a portion of at least one of the lateral edges and/or longitudinal edges, the flexible sidewall vertically extending away from the baseplate a predetermined distance;
wherein at least a portion of the predetermined distance of the flexible sidewall is operably deflectable relative to a vertical axis under a load;
wherein the baseplate and flexible sidewall collectively define a containment space.

US Pat. No. 10,889,429

SYSTEM AND METHOD FOR CONVERTING A COMMODITY TRAILER WITH GRAVITY DISCHARGE SLIDE GATES TO BE COMPATIBLE WITH A PNEUMATIC OUTLET GATE AND AN INTERCHANGEABLE PNEUMATIC GATE THEREFOR

WILSON TRAILER COMPANY, ...

1. A system for converting a hopper bottom trailer between gravity fed operation and pneumatic discharge operation comprising:a hopper bottom trailer having a bottom structure;
a conventional gravity fed sliding gate; and
a pneumatic outlet gate;
said gravity fed sliding gate and said pneumatic outlet gate being alternately and interchangeably retained on said same bottom structure of the hopper such that only one of said gate is carried by the trailer at any given time, the pneumatic gate being removed from the trailer when the gravity fed sliding gate is retained on the bottom structure and the gravity fed sliding gate being removed from the trailer when the pneumatic gate is retained on the bottom structure.

US Pat. No. 10,889,428

CONTAINER FOR CONSUMER GOODS WITH RECLOSABLE FLAP

JT International S.A.

11. A container for consumer goods, comprising:an outer housing comprising a hinged lid rotatable between an open position and a closed position;
an inner package of consumer goods within the outer housing comprising an access opening through which the consumer goods can be removed;
a reclosable flap arranged to cover the access opening and attached to the hinged lid, whereby the reclosable flap moves relative to the access opening during movement of the hinged lid between the open position and the closed position;
wherein the reclosable flap carries an indicium in a manner such that the indicium is not visible when the lid is in the closed position, the indicium provided by a printing medium at a position on the reclosable flap that is offset from the access opening when the hinged lid is in the closed position;
wherein the reclosable flap is attached to a first lid panel of the hinged lid such that a portion of the reclosable flap is substantially coplanar with a planar wall of the hinged lid, which is provided by the first lid panel, when the hinged lid moves between the open position and the closed position,
wherein the first lid panel is movable relative to a second lid panel during movement of the hinged lid between the open and closed positions;
wherein the coplanar portion of the reclosable flap carries at least a portion of the indicium such that the indicium becomes visible during movement of the hinged lid from the closed position towards the open position at an intermediate position in which the reclosable flap covers an entire periphery of the access opening.

US Pat. No. 10,889,427

CAN TAP

THE CHEMOURS COMPANY FC, ...

1. A container comprising:a refrigerant, self-sealing valve and having a can tap attached to the container wherein the can tap comprises housing having a body, a lower end having an inlet, an upper end having an outlet, a throat between the lower end and the upper end; a pin located within the housing having an upper end secured to the housing body, a lower end having a depressor suitable for contact with a can having a top in which is positioned a self-sealing valve, wherein the depressor is capable of operating the self-sealing valve of the can, and a flow portion between the upper end and the lower end of the pin located within the housing throat wherein the flow portion allows fluid to flow between the housing and the pin; and a tap outlet in fluid communication with the housing outlet at the upper end of the housing and further comprising a compressible gasket positioned adjacent the housing at or adjacent to the housing inlet and wherein the gasket has a hardness ranging from 70 durometers to 100 durometers.

US Pat. No. 10,889,426

DISPENSING CONTAINER

Oxygen Confectionery Corp...

1. An apparatus configured to dispense a plurality of items, the apparatus comprising:a container comprising a storage chamber configured to hold the plurality of items and a rest chamber;
a delivery member comprising a carrying holder and a holder adjusting apparatus;
wherein the holder adjusting apparatus is configured to adjust at least one dimension of the carrying holder so that the carrying holder carries at least one of the items;
wherein the delivery member is configured to move in a reciprocating motion between a stowed configuration and a dispensing configuration, wherein in the stowed configuration, the delivery member is located in the rest chamber of the container;
a first push button configured to engage the delivery member in reciprocating motion, the first push button comprising a detent, wherein in the stowed configuration, engagement of the detent of the first push button locks the delivery member in order to prevent unintended motion of the delivery member, and
wherein in the stowed configuration, the detent of the first push button is configured to lock the delivery member and a second push button is configured to engage the holder adjusting apparatus to change at least one dimension of the carrying holder in order to carry the at least one of the items.

US Pat. No. 10,889,425

PORTABLE BEVERAGE CONTAINER SYSTEMS AND METHODS FOR ADJUSTING THE COMPOSITION OF A BEVERAGE

LifeFuels, Inc., Reston,...

1. A beverage apparatus, the beverage apparatus being hand-holdable by a user of the beverage apparatus to be portable, the beverage apparatus comprising:a beverage chamber housing that includes a chamber, and the chamber storing a consumable liquid in the chamber;
a dispensing assembly that includes a first receptacle, and the first receptacle for retaining a first vessel, and the first vessel including a first electronic tag and containing a first additive,
the dispensing assembly operatively controllable to output the first additive from the first vessel into the consumable liquid;
an element that outputs:
first data, in conjunction with a first event, regarding a consumable liquid level in the chamber; and
second data, in conjunction with a second event, regarding the consumable liquid level in the chamber; and
an apparatus computer processor (ACP);
an apparatus database portion that includes instructions that are performed by the ACP in operation of the beverage apparatus, and the ACP configured to control the dispensing assembly to perform dispensing of the first additive from the first vessel into the consumable liquid, and the ACP performing first processing including:
inputting the first data from the element;
identifying a first predetermined attribute of the first data;
performing first comparing of the first predetermined attribute, of the first data, against predetermined criteria;
generating a first determination that the first predetermined attribute satisfies the predetermined criteria; and
based on the first determination, the ACP accepting the first data for generating the consumable liquid level;
the ACP performing second processing including:
inputting the second data from the element;
identifying a second predetermined attribute of the second data;
performing second comparing of the second predetermined attribute against the predetermined criteria;
generating a second determination that the second predetermined attribute does not satisfy the predetermined criteria; and
based on the second determination, the ACP rejecting the second data for generating the consumable liquid level.

US Pat. No. 10,889,424

PORTABLE BEVERAGE CONTAINER SYSTEMS AND METHODS FOR ADJUSTING THE COMPOSITION OF A BEVERAGE

LifeFuels, Inc., Reston,...

1. A beverage apparatus, the beverage apparatus being hand-holdable by a user of the beverage apparatus to be portable, the beverage apparatus comprising:a beverage chamber housing that includes a chamber, and the chamber storing a consumable liquid in the chamber;
a dispensing assembly that includes a first receptacle, and the first receptacle for retaining a first vessel, and the first vessel including a first electronic tag and containing a first additive,
the dispensing assembly operatively controllable by a controller to output the first additive from the first vessel into the consumable liquid;
a first element that is a first level sensor, the first level sensor outputs first data regarding level of the consumable liquid in the chamber;
a second element that is a second level sensor, the second level sensor outputs second data regarding the level of the consumable liquid in the chamber;
an apparatus computer processor (ACP);
an apparatus database portion that includes instructions that are performed by the ACP in operation of the beverage apparatus, and the ACP configured to control the dispensing assembly to perform dispensing of the first additive from the first vessel into the consumable liquid, and the ACP performing processing including:
inputting the first data from the first level sensor;
inputting the second data from the second level sensor;
performing first transform processing, to the first data, to generate a first collective certainty, which is associated with the first level sensor;
performing second transform processing, to the second data, to generate a second collective certainty, which is associated with the second level sensor;
generating a final determined liquid level (FDLL) based on the first collective certainty, first data, second collective certainty, and second data; and
performing liquid level processing based on the FDLL.

US Pat. No. 10,889,423

BONDING LABEL

1. A web of bonding labels comprising:a face stock having a top surface and a bottom surface with both a first adhesive layer and a first release layer on the top surface of the face stock and a second adhesive layer on the bottom surface of the face stock;
a release liner having a top surface and a bottom surface with a second release layer on the top surface of the release liner arranged to protect the second adhesive layer on the bottom surface of the face stock and a third release layer on the bottom surface of the release liner;
the face stock being separated into a succession of labels carried on the release liner such that each label includes a first complementary area defined on the top surface of the face stock by at least a portion of the first adhesive layer and a second complementary area that is at least as large as the first complementary area defined on the top surface of the face stock by at least a portion of the first release layer;
the third release layer on the bottom surface of the release liner being arranged to protect the first adhesive layer within the first complementary area of each label when the succession of labels carried on the release liner is wound into a roll; and
the first release layer within the second complementary area of each label being arranged to protect the first adhesive layer within the first complementary area of each label when the respective labels are removed from the release liner and folded together.

US Pat. No. 10,889,422

RESEALABLE PACKAGE AND ASSOCIATED MATERIALS, METHODS AND SYSTEMS FOR ITS MANUFACTURE

Frito-Lay North America, ...

1. An improved package precursor for an improved resealable package, wherein the precursor comprises:a wrapper;
at least one primary seal region of the wrapper;
a reseal region of the wrapper; and
cold seal adhesive;
wherein the wrapper comprises a product containment region for a product in the package, wherein the product containment region is configured to be at least a portion of a product containment surface of the package;
wherein the product containment surface of the package consists of all portions of the package configured to contain and potentially contact the product in the package while the package is initially unopened;
wherein the at least one primary seal region of the wrapper is configured to form at least one primary seal of the package;
wherein the reseal region is configured to adhere to itself when pressed against itself;
wherein the reseal region comprises a cold-seal-adhesive-coated region, wherein the cold-seal-adhesive-coated region is coated with the cold seal adhesive;
wherein the precursor is configured so that the cold seal adhesive that coats the reseal region forms (i) at least a portion of the product containment region of the wrapper, (ii) at least a portion of the product containment surface of the package while the package is initially unopened, and (iii) at least a portion of a product-facing surface of the package while the package is initially unopened.

US Pat. No. 10,889,421

UNIVERSAL STERILE PACKAGING ASSEMBLY

Stryker European Holdings...

1. A packaging assembly for an orthopedic device comprising:an outer blister having a first recessed central region;
an inner blister having a second recessed central region including a protrusion, the protrusion configured for securement of a medical part thereto, the inner blister sized to fit within the first recessed central region, the second recessed central region further including an elevated portion defined by a surface convexly curved upwards and away from a bottom surface of the second recessed central portion, the protrusion extending from the elevated portion and away from the bottom surface;
a first lid securable to the inner blister; and
a second lid securable to the outer blister so as to enclose the inner blister within the outer blister,
wherein the protrusion is two pins, at least one of the pins including a hook configured so that a medical part is securable thereto.

US Pat. No. 10,889,420

PACKAGING FOR A MULTIPART LANDSCAPE LIGHTING UNIT

Home Depot Product Author...

1. A method of packaging a lighting unit comprising a first component having a first elongate member and a second component that is physically separate from the first component, the second component having a second elongate member, the method comprising:connecting the first elongate member of the first component to the second elongate member of the second component with a resilient binding element comprising a first ring adapted to receive and hold the first elongate member at a first longitudinal location thereof, the first ring having an inner circumference that is less than an outer circumference of the first elongate member, the resilient binding element further comprising a second ring adjoining the first ring and adapted to receive and hold the second elongate member at a first longitudinal location thereof, the binding element at least partially inhibiting the first and second components from being longitudinally moved relative to each other;
inserting the first elongate member into a first aperture in a carrier base sized and shaped to receive the first elongate member at a second longitudinal location of the first elongate member, wherein the second longitudinal location of the first elongate member is spaced a distance from the first longitudinal location; and
inserting the second elongate member into a second aperture in the carrier base sized and shaped to receive the second elongate member at a second longitudinal location of the second elongate member, wherein the second longitudinal location of the second elongate member is spaced the distance from the first longitudinal location.

US Pat. No. 10,889,419

REMOVEABLE BAND WITH WINDOW FOR CONFINING STACKS OF DISPOSABLE CUTLERY

GPCP IP Holdings LLC, At...

1. A removeable band for confining a stack of cutlery pieces, comprising:a body having a first end and a second end, the body being an elongated strip of fiber-based material;
an opening proximate the first end of the body; and
an adhesive configured to adhere a first portion of the body to a second portion of the body to form a continuous band when the first end and the second end of the body at least partially overlap the other,
wherein the opening is not obstructed by either end of the body when the ends of the body at least partially overlap.

US Pat. No. 10,889,418

ELECTRONIC STORAGE CABINET

Knox Associates, Inc., P...

1. A container comprising:a frame that defines a storage space and includes an opening capable of receiving items storable within the storage space;
a door mounted to the frame so as to be movable between an open position that permits access to the storage space and a closed position that prevents access to the storage space; and
a lock verification system comprising:
a first accelerometer disposed in the door and configured to generate a first signal,
a second accelerometer disposed in the frame and configured to generate a second signal, and
a processor programmed to determine a motion of the container based at least in part on the first signal and the second signal, and to determine whether the door is open based at least in part on a comparison between the first signal and the second signal, wherein the processor is further configured to negate acceleration of a vehicle containing the container from the determination of whether the door is open by subtracting one of the first signal or the second signal from the other of the first signal or the second signal.

US Pat. No. 10,889,417

BOTTLE-SHAPED RESIN CONTAINER

NISHIAKI KOUSAKUSHO CO., ...

1. A bottle-shaped resin container comprising:a bottle main body including a neck portion and a body portion which are integrally formed, the neck portion having, on an outer periphery of the neck portion, a male threaded portion as well as an annular jaw portion and an annular flange portion each forming a horizontally projecting portion, the male threaded portion, the jaw portion, and the flange portion being formed downward from above in this order; and
a cap including a cap main body, a cap ring, and at least one bridge connecting the cap main body and the cap ring to each other, the cap main body being configured to include a female threaded portion formed on an inner periphery of the cap main body to be screwed onto the male threaded portion such that the female threaded portion is screwed onto the male threaded portion to allow the cap to close the neck portion, wherein:
the cap ring is in a ring shape, an upper end of the cap ring is connected to a lower end of the cap main body via the at least one bridge, the cap ring being formed to have a larger internal diameter than an external diameter of the jaw portion so that the cap ring is fitted on the jaw portion with a gap formed outside the jaw portion;
at least one stopper configured to engage with a lower end of the jaw portion from below is formed inside the cap ring so as to project in a direction toward an axis such that when the cap is screwed onto the neck portion after filling the bottle main body with content, an upper end of the at least one stopper is engaged with a lower surface of the jaw portion after the at least one stopper passes around the jaw portion;
a high-height cylindrical portion connecting the jaw portion and the flange portion to each other is provided between the jaw portion and the flange portion;
the high-height cylindrical portion has a height (H) of 10 to 20 mm, and the high-height cylindrical portion has a lateral surface extending in a circumferential direction from the jaw portion to the flange portion, the lateral surface being smooth around an entire circumference of the high-height cylindrical portion in the circumferential direction, the lateral surface having a profile of straight lines when seen from a front, and a central portion of the lateral surface in a vertical direction of the lateral surface concaves inwardly from each upper and lower edge of the lateral surface in the vertical direction;
the at least one bridge is formed on an outer peripheral side of the cap ring; and
when the cap main body is rotated in a direction in which the female threaded portion is unscrewed from the male threaded portion, thus discharging the content from the bottle main body, the at least one bridge is broken by shear force to separate the cap ring from the cap main body, and as a result the cap ring drops down due to a weight of the cap ring in a state in which the axis extends in a vertical direction so that a lower surface of the cap ring comes into contact with the flange portion, the cap ring remains on the flange portion and the lateral surface of the high-height cylindrical portion is exposed between an upper surface of the cap ring and the lower surface of the jaw portion, which makes it possible to determine that the cap is already opened.

US Pat. No. 10,889,416

CHILD RESISTANT CONTAINER AND METHOD OF OPENING SAME

CSP TECHNOLOGIES, INC., ...

1. A method of opening a child resistant container, the container comprising a body comprising a base, a sidewall extending from the base, and an end portion disposed opposite the base, the end portion defining an opening leading to an interior of the body configured to loosely contain a plurality of products therein, a lid connected to the body via a hinge, the lid comprising a cover portion and a protrusion extending outwardly from one side of the cover portion, the cover portion being configured to move between a FIRST position and a SECOND position; and a directing portion extending from one of the body and the cover portion, the directing portion at least partially enclosing the protrusion when the cover portion is in the FIRST position, the method comprising the steps of:inserting a tool between the directing portion and the cover portion;
engaging the tool with the protrusion, thereby causing an end of the protrusion to pivot toward the one side of the cover portion; and
moving the cover portion to the SECOND position, thereby opening the container.

US Pat. No. 10,889,415

COOLER DRAIN ASSEMBLY

TXUS PRODUCTS, LLC, Hous...

1. A cooler drain assembly comprising:an outer sleeve member defining an interior passage within, the outer sleeve member being shaped and sized to be received within a drain plug opening of a food and beverage cooler;
an inner sleeve member having a body which defines a flow bore within, the body of the inner sleeve member being received within the interior passage of the outer sleeve member and rotatable therewithin, wherein the flow bore within the inner sleeve member extends from a closed end of the inner sleeve member to an opposite open end of the inner sleeve member;
a snap ring secured to a lateral surface of the shaft portion of the inner sleeve member adjacent the closed end, wherein the snap ring secures the inner sleeve member within the interior passage of the outer sleeve member;
a lateral window disposed through the body of the inner sleeve member; and
an opening within the outer sleeve member, such that rotation of the inner sleeve member within the outer sleeve member selectively aligns the opening with the lateral window so that fluid is allowed to pass from the food and beverage cooler into the flow bore and out the open end of the inner sleeve member.

US Pat. No. 10,889,414

FOOD CONTAINER WITH VENTS ON HANDLES

FREE-FREE INDUSTRIAL CORP...

1. A food container, comprising:a box, comprising a box wall and a receiving room encompassed by the box wall, the box wall being provided with a pair of handle portions, each handle portion being extended with a bent section from the box wall toward a direction which is bent away from the receiving room, and an upper portion of each bent section being formed with a venting space communicating with the receiving room; and
a cover, removably fastened to the box to cover the receiving room, comprising a cover plate, the cover plate comprising a pair of handle lids and a pair of sliding seals, the pair of handle lids corresponding to the pair of handle portions in position, each handle lid being capable of being fixed to one of the handle portions to cover the venting space, each handle lid being provided with vents corresponding to the venting space, and the pair of sliding seals being disposed in the pair of handle lids correspondingly to be capable of selectively cloaking the vents.

US Pat. No. 10,889,413

TAMPER-EVIDENT CONTAINER WITH A TAB EXTENDING BEYOND A HINGE

Genpak, LLC, Charlotte, ...

1. A tamper-evident container comprising:a base comprising a base extension, the base extension having a first end opposite from a second end;
a lid comprising a lid extension, the lid extension having a first end opposite from a second end;
a hinge, wherein the base extension connects the base to the hinge, wherein the lid extension connects the lid to the hinge, and wherein the hinge has a first section opposite from a second section; and
a tab extending from either the lid extension or the base extension;
wherein, when the container is in a closed, pre-use configuration with the lid coupled to the base, the tab extends in a direction away from the lid and the base such that the tab extends beyond the hinge;
wherein, when the container is in the closed, pre-use configuration, the tab comprises a free edge that defines an outermost perimeter of the tab between a first end and a second end;
wherein, when the container is in the closed, pre-use configuration, a first weakened region in the same extension from which the tab extends is located between the first end of the free edge of the tab and a terminal end of the first weakened region and a second weakened region in the same extension from which the tab extends is located between the second end of the free edge of the tab and a terminal end of the second weakened region;
wherein the hinge is not coaxially aligned with the free edge of the tab, the first weakened region, or the second weakened region; and
wherein, when the container is in a closed, pre-use configuration, the container is opened by tearing along the first weakened region from the first end of the free edge of the tab to the terminal end of the first weakened region and by tearing along the second weakened region from the second end of the free edge of the tab to the terminal end of the second weakened region such that the lid and the base are separated.

US Pat. No. 10,889,412

PAPER CLOSURES FOR PAPER CONTAINERS

1. A closure for use in sealing an opening of a vessel having a curled upper rim, comprising:a substantially flat lid comprising a fibrous material having a top surface, a bottom surface, and a curved perimeter surface; and
a ring-shaped, rigid bead, comprising a water-based, biodegradable adhesive material, that is cured to be non-adhesive, the bead positioned inwardly from the perimeter, and extending downwardly from the lid;
wherein the lid and the bead are further configured such that when the closure is sealingly mated with the vessel, the bottom surface of the lid is configured to mate with a top edge of the curled upper rim, and the bead is configured to mate with an inner surface of the curled upper rim.

US Pat. No. 10,889,411

CONTAINER WITH LID AND DETACHABLE LID COLLAR

Berry Plastics Corporatio...

1. A package comprisinga container formed to include a product-storage region and a mouth arranged to open into the product-storage region and
a closure configured to mate with the container and establish a closed arrangement of the package and to be separated from the package at the option of a user to establish an opened arrangement,
wherein the closure includes a lid collar and a lid and the lid collar is arranged to extend around and surround a top portion of the container and the lid is coupled to the lid collar in a fixed position relative to the lid collar when the package is in the closed arrangement, the lid is rotatable about a longitudinal axis of the container relative the lid collar to cause the lid to change and provide the opened arrangement of the package,
wherein the lid collar is movable along the longitudinal axis relative to the container when the lid is in the opened arrangement so as to leave the container spaced-apart from the lid collar and the lid, and
wherein the lid includes a cap arranged to cover the mouth of the container when the package is in the closed arrangement, a lid thread coupled to the cap and arranged to extend toward the lid collar to mate with a collar thread included in the lid collar, and a band coupled to the cap and arranged to extend downwardly away from the cap.

US Pat. No. 10,889,410

MOBILITY ASSEMBLY FOR A CONTAINER

Kathryn Heather Maurier, ...

1. A mobility assembly for a container comprising:a handle bracket arranged to attach to a first chime of a container having a body extending between a first wall and a second wall, the first chime having an inner surface and an outer surface each extending between the first wall and a rim of the first chime, the rim extending between distal ends of the inner and outer surfaces, the first chime extending from the first wall;
a handle arranged to attach to the handle bracket and a leveling member that extends from the second wall and is spaced apart from the wheel assembly.

US Pat. No. 10,889,409

PACKAGE CONTAINING FLUID CONTENT

TOYO SEIKAN GROUP HOLDING...

1. A package including a container body containing a fluid content leaving a head space, whereinthe container body has an inner surface on which ruggedness is formed entirely,
the inner surface with the ruggedness of the container body is coated with a lubricating liquid immiscible with the fluid content, and the lubricating liquid is present as a coating layer interposed between the inner surface and the fluid content,
the lubricating liquid for forming the coating layer forms a liquid pool at a periphery of an upper end face of the fluid content contained in the container body in a state of being held upright, and
wherein in an upright state, an excess amount of the lubricating liquid flows down from the head space onto the periphery of the upper end face of the content so as to form a liquid pool with a bottom face on the upper end face of the content.

US Pat. No. 10,889,408

MICRONEEDLE PATCH STORAGE TOOL, LOWER PALLET AND UPPER PALLET

COSMED PHARMACEUTICAL CO....

1. A microneedle patch storage tool configured to hold a microneedle patch, the microneedle patch storage tool comprisinga plurality of pallets stacked in a vertical direction,
wherein pallets adjacent in the vertical direction among the plurality of pallets constitute one or a plurality of patch holding parts configured to hold the microneedle patch,
wherein the patch holding part comprises a first base part and a second base part that are arranged in the vertical direction,
wherein the first base part comprises;
a first opening having a shape configured to be corresponding to a needle forming surface of a microneedle patch which the microneedle patch storage tool is intended to hold, and
a plurality of first protrusions arranged in circumferentially divided manner around the first opening,
wherein the second base part comprises;
a second opening having a shape configured to be corresponding to the needle forming surface of the microneedle patch which the microneedle patch storage tool is intended to hold, and
a plurality of second protrusions arranged in circumferentially divided manner around the second opening, and
wherein the plurality of first protrusions and the plurality of second protrusions are configured to sandwich a peripheral edge part of the microneedle patch which the microneedle patch storage tool is intended to hold, in the vertical direction, and
wherein for each patch holding part, a plurality of side wall pieces are provided radially outward of the first protrusions and are arranged separately from each other and in circumferentially divided manner to surround the same first opening surrounded by the first protrusions, the side wall piece has a larger height than the first protrusion, and the second protrusions are positioned to be corresponding to the first protrusions.

US Pat. No. 10,889,407

CONVERTIBLE PALLET FOR USE AS A CART

CREATIVE EDGE DESIGN GROU...

1. A convertible pallet for supporting and transporting associated product received thereon, the pallet comprising:a substantially planar support member having an upper surface for receiving the associated product thereon and a lower surface configured to receive an arm from an associated lift assembly;
at least first and second wheels mounted to the lower surface;
a convertible support surface movably mounted to at least one of the upper and lower surfaces, the convertible support surface having (i) a first position where the convertible support surface receives loads imposed on the upper surface and transfers the loads directly to an associated surface, and (ii) a second position where the wheels extend outwardly from the lower surface for engagement with the associated surface so that loads imposed on the upper surface are transferred to the associated surface through the wheels and for converting the pallet into a movable cart; and
first and second guide pins configured for operative receipt in first and second grooves, respectively, the first guide pin extending from one of the support member and convertible support surface, and the first and second grooves provided on an other of the support member and convertible surface, wherein the first and second grooves are dissimilarly shaped, the first groove is L-shaped and the second groove includes an arcuate region between the ends, and each end of each of the first and second grooves includes an offset that receives the guide pin when the convertible support surface is oriented in one of the first and second positions, and the first guide pin configured for receipt in the first groove and the second guide pin configured for receipt in the second groove whereby ends of the first and second grooves define stop positions for the respective first and second positions of the convertible surface.

US Pat. No. 10,889,406

SYSTEM OF OPEN-TOPPED CONTAINERS

SAEPLAST ICELAND EHF, Da...

1. A system of containers, the system comprising:at least two alternately vertically stackable open-topped male and female containers that each comprise a single continuous structural unit, so that within a stack a male container meets a female container and vice versa,
each male container comprising:
a substantially rectangular bottom having an upper surface, a lower surface and an outer edge of each side thereof
two pairs of oppositely located side walls extending from the bottom, each side wall having a rim disposed at an upper end of each side wall, the rims of the side walls being interconnected to form an opening, the lower end of the side walls being interconnected with the bottom at an inwardly position from the outer edge thereof, at least a portion of the outer surface of each of the side walls of the male container extending angularly inwardly from the bottom towards an opposing side wall such that a distance between rims of each pair of oppositely located side walls is smaller than a distance between the lower ends of each pair of oppositely located side walls, and
each female container comprising
a substantially rectangular bottom having an upper surface, a lower surface and an outer edge of each side thereof,
two pairs of oppositely located side walls extending substantially vertically from the bottom, each side wall having a rim disposed at an upper end of each side wall to form an opening, and
wherein, when the female container is turned by 180° from an upright position, the walls of the male container will fit within the opening of the female container.

US Pat. No. 10,889,405

INTEGRATED INSERT FOR CARDED PRODUCT STABILIZATION

WestRock Shared Services,...

1. A carded product stabilization device, comprising: at least four sections adjoined to one another via a plurality of first fold lines to form a box-like structure; and a first section adjoined to at least one of the at least four sections via a second fold line that is orthogonal to at least one of the first fold lines, wherein the first section is folded along the second fold line so as to have at least one first portion, the first portion being orthogonal to the at least one of the at least four sections and at least one second portion, the second portion being acutely angled with respect to the at least one first portion, wherein the first section comprises at least one slot spanning at least into the at least one first portion.

US Pat. No. 10,889,404

CHILD-RESISTANT PACKAGING

DENALI INNOVATIONS, LLC, ...

1. A child-resistant package, comprising:a tray;
a sleeve;
wherein said tray is configured to be inserted into said sleeve;
wherein said sleeve comprises one or more internal protrusions, one or more access holes, and a front flap;
wherein said tray comprises an insert and a rigid base;
wherein said insert comprises one or more external protrusions;
wherein said insert further comprises a back flap that is configured to pass through a slot of said rigid base;
wherein said front flap and said back flap are configured to engage with each other, such that said tray is substantially prevented from being entirely removed from said sleeve;
wherein said insert is configured to matingly engage with said rigid base, such that said one or more external protrusions are external to one or more sides of said rigid base;
wherein said one or more internal protrusions are configured to engage with said one or more external protrusions when said tray and said sleeve are in a closed position, such that said tray is substantially prevented from being taken out of said closed position without disengaging said one or more external protrusions from said one or more internal protrusions; and
wherein each of said one or more access holes overlap with an end of each of said one or more external protrusions, such that a user may access and disengage said one or more external protrusions from said one or more internal protrusions, such that said tray is no longer prevented from being taken out of said closed position.

US Pat. No. 10,889,403

WOUND PACKAGE CONSTRUCT

General Mills, Inc., Min...

1. A wound package construct comprising:a liner strip wound as a liner layer, the liner strip including two opposed liner edges, the opposed liner edges meeting at a spiral liner seam to form the liner layer having an interior side and an exterior side;
a bodystock strip wound as a bodystock layer on the exterior side of the liner layer, the bodystock strip including two opposed bodystock edges, the opposed bodystock edges meeting at a spiral bodystock seam to form the bodystock layer having an interior side and an exterior side;
a liner adhesive, provided between the exterior side of the liner layer and the interior side of the bodystock layer, bonding the liner layer and the bodystock layer;
a cover strip spirally wound on the exterior side of the bodystock layer and covering the spiral bodystock seam, the cover strip including adjacent cover strip edges that do not meet and do not overlap so as to remain spaced apart between the wound cover strip such that portions of the bodystock layer are exposed between the adjacent cover strip edges when the cover strip is fully wound on the bodystock layer; and
a cover adhesive, provided between the exterior side of the bodystock layer and an interior side of the cover strip, bonding the cover strip and the bodystock layer to establish a container.

US Pat. No. 10,889,402

REFILLABLE PET CONTAINER

AMCOR RIGID PACKAGING USA...

1. A refillable container comprising:a finish defining an opening to an internal volume of the container, the finish at a first end of the container;
a base at a second end of the container that is opposite to the first end;
a standing surface included with the base at the second end; and
a push-up portion of the base surrounded by the standing surface, the push-up portion including:
a central portion at a center of the base and recessed inward from a plane extending across the standing surface, a longitudinal axis of the container extends from the first end to the second end through the central portion; and
a substantially linear portion extending radially outward from the central portion to a standing ring of the base;
wherein the substantially linear portion and the central portion are movable away from the first end of the container in response to an increase of internal pressure within the container and towards the first end of the container when the pressure decreases, the substantially linear portion remains substantially linear as the substantially linear portion moves towards the first end of the container;
wherein the substantially linear portion gradually and uniformly decreases in thickness as the substantially linear portion extends outward from the central portion to the standing ring; and
wherein the substantially linear portion is at a first acute angle relative to a plane extending across the standing surface and moves to a second acute angle relative to the plane after the substantially linear portion moves away from the first end of the container in response to the increase of internal pressure within the container.

US Pat. No. 10,889,401

LABEL APPLICATION SYSTEMS

ACTEGA North America Tech...

1. A system for applying decorations to substrates, comprising:a continuous web including a plurality of decorations provided on a first side of the web, each decoration having an adhesive exposed on a surface of the decoration facing outwardly from the first side of the web;
an application station at which the decorations are applied from the web to substrates;
a web path along which the web travels to transport the decorations to the application station, wherein the web and the web path are arranged such that the web travels along the web path both to and away from the application station;
a web control system including at least one web controller, wherein the web control system is configured to stop movement of the web when a decoration is positioned at the application station; and
a substrate transport configured to move a substrate through the application station while the web is stopped to move the substrate relative to the decoration positioned at the application station and apply the decoration to the substrate.

US Pat. No. 10,889,400

METHOD OF UNWRAPPING A PALLETIZED LOAD AND DEVICE FOR CARRYING OUT SAID METHOD

1. A method of unwrapping a generally parallelepiped palletized load comprising:providing a palletized load surrounded by a plastics material,
making vertical and/or horizontal linear cuts in the plastics material which surrounds the palletized load, wherein at least one of the linear cuts has a discontinuous cut portion which comprises a plurality of cuts of a certain length and constant pitch, and
tearing said discontinuous cut portion,
trapping the torn edges of the plastics material that surrounds the palletized load by robotic arms to hold said plastics material and
subsequently advancing the palletized load to unwrap the palletized load.

US Pat. No. 10,889,399

PACKAGING SYSTEMS WITH CLIPPER TRIGGER AND RESET CAM ASSEMBLIES EACH COMPRISING A PLURALITY OF CAMS AND RELATED CAM ASSEMBLIES

Tipper Tie, Inc., Apex, ...

1. A packaging system comprising:a rotatable table supported by a rotatable column;
a plurality of circumferentially spaced apart clipper assemblies positioned at respective clipper stations at the rotatable table;
a plurality of spaced apart pneumatic valves rotatable with the table in fluid communication with the clipper assemblies; and at least one of:
(a) a clipper reset cam assembly having first and second reset cams that selectively automatically engage the pneumatic valves as the table rotates, wherein the first and second reset cams are reset standard and reset early cams, wherein the reset early cam initiates operation of the clipper earlier than the reset standard cam; or
(b) a clipper trigger cam assembly having first and second trigger cams that selectively automatically engage the pneumatic valves as the table rotates, wherein the first and second trigger cams are trigger standard and trigger early cams, and the trigger early cam initiates a clipping cycle earlier than the trigger standard cam.

US Pat. No. 10,889,398

DEVICE AND MACHINE FOR MAKING FILTER BAGS OF TETRAHEDRAL SHAPE

1. A machine for forming filter bags of tetrahedral shape containing infusion product, the machine comprising:a forming and joining station to form a continuous strip of filter material and create a continuous tube of filter material, the forming and joining station comprising:
i) a forming tube configured to be wound by the continuous strip of filter material moving along a feed direction, the forming tube comprising a hollow forming element extended along a longitudinal axis parallel to the feed direction and having a first opening and a second opening communicating by means of an inner through cavity through which the infusion product entering from the first opening flows to exit from the second opening so as to be dosed inside a filter bag in formation, the forming element comprising a main cylindrical body and a forming member, the forming member having a connecting portion proximal to the main cylindrical body and a forming portion distal from the main cylindrical body, the forming portion being provided with the second opening and having a maximum transversal dimension greater than the maximum transversal dimension of the connecting portion;
ii) a longitudinal sealing element configured to form a continuous longitudinal seal at a free longitudinal edges of the continuous strip of filter material, in order to form the continuous tube of filter material;
a feeding station for feeding the infusion product inside the inner through cavity;
a sealing station comprising transversal sealing elements configured to make transversal seals on the continuous tube of filter material, the transversal seals being alternately rotated by 90° on a plane perpendicular to the longitudinal axis,
wherein the forming member is rotatable joined to the main cylindrical body to rotate about the longitudinal axis, and wherein the connecting portion of the forming member has a transversal cross section which is circular relative to a plane transversal to the longitudinal axis and the forming portion of the forming member has a transversal cross section which is elongate relative to a plane transversal to the longitudinal axis.

US Pat. No. 10,889,397

UNIT AND METHOD FOR FILLING CONTAINERS OF SINGLE-USE CAPSULES FOR EXTRACTION OR INFUSION BEVERAGES

I.M.A. INDUSTRIA MACCHINE...

1. A unit for filling containers with a dose of product, comprising:a line for transporting containers along a movement path and provided with a plurality of supporting seats for the containers arranged in succession along the movement path;
a filling station for filling the containers with a dose of the product;
the filling station comprising:
a containing seat in a containing element and configured to receive a dose of the product;
a movement device configured to move the containing element about a rotational axis for moving the containing seat along a closed path;
an adjusting device configured to move the containing element radially relative to the rotational axis, for adjusting the position of the containing seat between a receiving position for receiving the dose of the product and a releasing position for releasing the dose of the product from the containing seat into one of the containers transported by the transport line;
a forming substation where the dose of the product is formed inside the containing seat, provided with a releasing device for feeding the dose of the product inside the containing seat, when the containing seat is at the receiving position;
a compacting substation where the dose of the product is compacted inside the containing seat, provided with a compacting element movable along a compacting axis, parallel to the rotational axis, between a raised position in which the compacting element is outside the containing seat and a lowered position in which the compacting element is inside the containing seat, the compacting element moving from the raised position to the lower position when the containing seat is at the receiving position; and
a releasing substation where the dose of the product is released by an ejection device from the containing seat into said one of the containers transported by the transport line, when the containing seat is positioned in the releasing position,
the adjusting device being driven to place the containing seat in the receiving position at the forming substation and in the releasing position at the releasing substation,
wherein the forming substation comprises a hopper containing the product and the releasing device extends along a longitudinal axis between a first end cooperating with the containing seat when the containing seat receives the dose of the product and a second end communicating with the hopper for creating a feeding flow of the product from the second end towards the first end, for feeding the product into the containing seat in the receiving position,
wherein the longitudinal axis of the releasing device is at an oblique angle of inclination to a horizontal plane, whereby the first and second ends are offset from a common axis which is parallel to the rotational axis; and
wherein the compacting substation is located along the closed path between the forming substation and the releasing substation, and the releasing device is removed from the containing seat when the compacting element moves from the raised position to the lowered position, whereby the compacting element does not interfere with the releasing device.

US Pat. No. 10,889,396

VEGETABLE BINDING PACKING MATERIAL HAVING AIR COLUMNS, VEGETABLE BINDING PACKING DEVICE USING SAME, AND METHOD THEREFOR

1. A vegetable binding packing device comprising:a packing material supply unit configured to feed a packing material having an air column pattern formed between double-layered films;
a clamp injection module having a clamping part configured to clamp a front portion of the packing material and an injection part configured to inject air into the air column pattern;
a vegetable supply unit configured to supply vegetables to be packed, to a middle portion of the packing material between the front portion and a rear portion of the packing material in a direction crossing the packing material in a state in which the front portion is supported by the clamp injection module and the rear portion is supported by the packing material supply unit; and
a sealing module configured to pressurize and support the front portion and the rear portion of the packing material such that the front portion and the rear portion overlap each other with the vegetables surrounded by the middle portion of the packing material, and to seal a portion of the air column pattern across the air column pattern injected with air,
wherein the sealing module comprises:
a sealing head configured to pressurize and bond overlapped portions of the packing material;
a pair of sealing guides disposed at front and rear sides of the sealing head to pressurize and support both sides of the overlapped portions; and
an air blocking part disposed between the sealing head and the sealing guide at the rear side among the pair of sealing guides to pressurize and block the air column pattern before a bonding operation of the sealing head.

US Pat. No. 10,889,395

APPARATUS FOR PROCESSING BALES, FOR AGRICULTURAL MACHINES

KVERNELAND GROUP RAVENNA ...

1. An apparatus for processing bales, for agricultural machines provided with a forming chamber for forming a cylindrical bale, the apparatus comprising:a structure for supporting a reel of banded material, designed to wrap the bale;
a device configured for transferring and delivering an end flap of the reel to the forming chamber, said device being provided with an end blade which moves along a work path from a first limit position, in which the blade is proximate to the reel for the withdrawal of the end flap, to a second limit position, in which said blade faces toward the forming chamber, for the delivery of the flap to the chamber, and vice versa,
wherein the work path includes a rotation component and a translation component for the blade, relative to the forming chamber,
wherein the device includes a cam mechanism and wherein the cam mechanism includes a guide slot and a bearing which slides into the guide slot.

US Pat. No. 10,889,394

MACHINE TO MANUFACTURE CARTRIDGES FOR ELECTRONIC CIGARETTES AND PLANT FOR THE PRODUCTION OF PACKAGES CONTAINING SAID CARTRIDGES FOR ELECTRONIC CIGARETTES

1. A machine (11) to manufacture cartridges (3) for electronic cigarettes (2) comprising a casing (5) made of plastic material having a microperforated bottom wall (6) and a side wall (7) and containing a quantity of powdered tobacco on top of which a portion (8) of filtering material is arranged; the manufacturing machine (11) comprises:a feeding conveyor (13) which feeds a plurality of empty casings (5) in correspondence to a collecting station (PS);
a first drum (12) rotating at a predetermined pitch around its own vertical rotation axis, which receives an orderly mass of empty casings (5) from the feeding conveyor (13), in correspondence to the collecting station (PS), and feeds them through a succession of processing stations (FS, WRS, FRS, CDS, CS); wherein the first drum (12) is provided with a plurality of peripheral first seats (23), each designed to receive a respective casing (5), and which are divided into groups comprising the same number of first seats (23); in which the casings (5) of the first seats (23) of a same group are simultaneously subjected to the processes in correspondence to the succession of the processing stations (FS, WRS, FRS, CDS, CS); and
a second drum configured to receive semi-finished cartridges (3) transferred from the first drum (12) to the second drum (17) in correspondence to a loading/unloading station (CDS) in which the first drum (12) partially overlaps the second drum (17), wherein the second drum (17) is provided with a number of second seats (70) obtained on the periphery of the second drum (17) and which are divided into groups.

US Pat. No. 10,889,393

MACRO BLISTER PACKAGING

BAYER PHARMA AKTIENGESELL...

1. Macro blister pack, comprising a flat body, in which cavities for receiving individual medicinal product portions are formed, the cavities being filled with individual medicinal product portions and sealed by a film, the macro blister pack containing a number T of medicinal product portions, characterized in that T is at least 60 and the flat body has an extent in the range from 200 mm×200 mm to 1200 mm×1200 mm and which has at least one machine-readable marking that specifies where said macro blister pack can be divided into smaller blister pack units.

US Pat. No. 10,889,392

COVERED CONTAINER MANUFACTURING DEVICE AND BLISTER PACKAGING MACHINE

CKD CORPORATION, Aichi (...

1. A covered container manufacturing device for manufacturing a resin covered container that comprises: a container main body in which an article is placed; an outer cover portion that opens and closes an opening of the container main body; and a hinge portion that couples the container main body with the outer cover portion, wherein the container main body, the outer cover portion and the hinge portion are integrally formed,the covered container manufacturing device comprising:
an angle regulator that regulates a relative angle of the outer cover portion with respect to the container main body to a predetermined angle of less than 180 degrees, wherein
the angle regulator comprises:
a heater that comprises a heating portion that generates heat and heats the hinge portion; and
a bender that bends the outer cover portion relative to the container main body at the heated hinge portion,
wherein when the outer cover is bent over the container main body, the heater is pressed against an interior of the hinge portion and heats the interior of the hinge portion.