US Pat. No. 10,138,832

APPARATUS AND METHOD FOR CONTROLLING ENGINE

Hyundai Motor Company, S...

1. An engine control apparatus, comprising:an engine;
an accelerator pedal position sensor configured to measure a position of an accelerator pedal in response to an operation of the accelerator pedal;
a memory configured to store a map data;
a vehicle controller configured to calculate a driver demand torque based on the position of the accelerator pedal, to determine a current engine torque based on the map data, to verify whether the driver demand torque is equal to or greater than the current engine torque when the position of the accelerator pedal is deviated from a reference position while the engine is operated in a part load mode and to determine a transition of an engine mode of the engine to a full load mode; and
an engine controller configured to transition the engine mode to the full load mode from the part load mode in response to a control signal from the vehicle controller,
wherein the engine controller detects a throttle valve opening using a sensor and provides the detected throttle valve opening to the vehicle controller, and
wherein the vehicle controller determines whether the engine is operated in the part load mode based on the detected throttle valve opening.

US Pat. No. 10,138,831

CONTROLLER AND CONTROL METHOD FOR INTERNAL COMBUSTION ENGINE

Mitsubishi Electric Corpo...

1. A controller for an internal combustion engine that is provided with an intake path and an exhaust path, a throttle valve for opening and closing the intake path, an EGR path for recirculating exhaust gas from the exhaust path to an intake manifold which is a part of the intake path at the downstream side of the throttle valve, and an EGR valve for opening and closing the EGR path, the controller for the internal combustion engine comprising:a driving condition detector that detects an inner-manifold oxygen concentration which is an oxygen concentration of gas in the intake manifold, an intake air flow rate which is a flow rate of intake air taken into in the intake path, and an opening degree of the EGR valve;
an oxygen concentration detecting EGR rate calculator that calculates an oxygen concentration detecting EGR rate, which is a ratio of a recirculation exhaust gas which is the exhaust gas recirculated into the intake manifold, to the intake air, based on the inner-manifold oxygen concentration;
an opening area learning value calculator that calculates an oxygen concentration detecting recirculation flow rate which is a flow rate of the recirculation exhaust gas based on the oxygen concentration detecting EGR rate and the intake air flow rate, calculates an oxygen concentration detecting opening area which is an opening area of the EGR valve which realizes the oxygen concentration detecting recirculation flow rate, and calculates a learning value of the opening area of the EGR valve based on the oxygen concentration detecting opening area; and
a recirculation exhaust gas calculator for control that calculates a learned opening area of the EGR valve corresponding to the present opening degree of the EGR valve using the learning value of the opening area, and calculates a flow rate of the recirculation exhaust gas for control used for controlling the internal combustion engine based on the learned opening area.

US Pat. No. 10,138,830

SYSTEMS AND METHODS FOR ENGINE CONTROL

Ford Global Technologies,...

1. A method, comprising:during engine operation with a commanded amount of exhaust gas recirculation (EGR), responsive to at least one of an integrated knock intensity of an engine being greater than a threshold intensity and a fuel control correction of fuel supplied to the engine being greater than a threshold enrichment, setting an EGR rate to zero.

US Pat. No. 10,138,829

CONTROL APPARATUS FOR INTERNAL COMBUSTION ENGINE

Toyota Jidosha Kabushiki ...

1. A control apparatus for an internal combustion engine configured to infect fuel into a cylinder, the internal combustion engine includingan EGR apparatus configured to supply a part of exhaust gas into the cylinder as EGR gas, and
a low density substance supply apparatus configured to supply a low density substance having a lower density than the EGR gas into the cylinder, the control apparatus comprising an electronic control unit configured to
(i) calculate an equivalence ratio of the internal combustion engine and
(ii) control the EGR apparatus and the low density substance supply apparatus such that, when the equivalence ratio is high, a supply rate of the low density substance increases and a supply rate of the EGR gas decreases relative to when the equivalence ratio is low.

US Pat. No. 10,138,827

EVAPORATIVE EMISSIONS SYSTEM CHECK VALVE MONITOR FOR A MULTI-PATH PURGE EJECTOR SYSTEM

Ford Global Technologies,...

1. A method comprising:storing fuel vapors from a fuel system, which supplies fuel to an engine, in a fuel vapor storage canister;
coupling the fuel vapor storage canister to an air intake of the engine through a second path having a second check valve which prevents unmetered air from being drawn into an intake manifold of the engine when a canister purge valve is open;
diagnosing whether the second check valve is stuck open based on a temperature change of the fuel vapor storage canister;
preventing positive pressure with respect to atmospheric pressure from being communicated to the fuel vapor storage canister under conditions of positive pressure in the intake manifold via a first check valve in a first path; and
wherein diagnosing whether the second check valve is stuck open includes an indication that the first check valve is not stuck open.

US Pat. No. 10,138,793

EXHAUST GAS PURIFICATION SYSTEM AND METHOD FOR CONTROLLING THE SAME

Bosch Corporation, Tokyo...

4. A method for controlling an exhaust gas purification system including a diesel particulate filter (DPF) for collecting exhaust particles contained in exhaust gas; a reducing agent injection valve for injecting urea aqueous solution as a reducing agent in the exhaust gas; an SCR catalyst for using the urea aqueous solution to purify NOx contained in the exhaust gas, in this order from the exhaust upstream side, and an engine controller, the method comprising:predicting whether or not the urea aqueous solution will be solidified when it is assumed that the internal-combustion engine is stopped in a period from when forced regeneration of the DPF is started to when it is ended or within a predetermined period from when it is ended; and notifying an operator of the internal-combustion engine when predicting that the urea aqueous solution will be solidified.

US Pat. No. 10,138,785

ARRANGEMENT FOR AND METHOD OF FEEDING AMMONIA CONTAINING FLUID INTO THE EXHAUST GAS PASSAGE OF A COMBUSTION PLANT

Sumitomo SHI FW Energia O...

1. An arrangement for feeding ammonia containing fluid into an exhaust gas passage of a combustion plant comprising:a first fluid line connectable in flow connection with a source of an ammonia containing fluid;
a second fluid line in flow connection with a source of a dilution fluid; and
an open flow path controller for controlling multiple valve members of a valve unit, each of the valve members having a first inlet in flow connection with the first fluid line, a second inlet in flow connection with the second fluid line and an outlet in flow connection with an outlet channel connected to the exhaust gas passage, the valve members being connected in parallel so that the outlet of each of the valve members is in flow connection with the outlet channel, wherein the open flow path controller is adapted for controlling each of the valve members to maintain an open flow path from either of the first inlet or the second inlet to the outlet, so as to feed a flow of either the ammonia containing fluid or the dilution fluid via the valve member to the outlet channel.

US Pat. No. 10,138,728

CONTROLLING AN OUTPUT OF A MINING SYSTEM

Joy Global Underground Mi...

1. A computer implemented method for controlling operation of a mining system, the mining system including a shearer and a conveyor, the method comprising:determining, using a processor, a position of the shearer based on a first signal from a first sensor, the first signal associated with the position of the shearer;
determining, using the processor, a load of the conveyor based on a second signal from a second sensor, the second signal associated with the load of the conveyor;
determining, using the processor, an output of the mining system based on the determined position of the shearer and the determined load of the conveyor;
generating, using the processor, a first control signal for a first drive mechanism to control a speed of the shearer based on the determined output of the mining system; and
generating, using the processor, a second control signal for a second drive mechanism to control a speed of the conveyor based on the determined output of the mining system.

US Pat. No. 10,138,678

SPRING SYSTEM FOR ROLLER BLINDS

Hunter Douglas Industries...

1. A method of selecting one or more springs for a roller blind, comprising:providing a roller blind including a roller, a sheet attached to said roller for winding and unwinding from said roller, and a bottom rail;
determining one or more parameters of the blind, including a roller length, a roller outer diameter, a sheet length, a sheet weight, a sheet height, a sheet thickness, and a bottom rail weight;
determining a torque curve of the blind based on the one or more parameters of the blind;
selecting a first spring having a wire diameter and a spring diameter, said first spring being operatively connected to the roller to drivingly rotate the roller in at least one direction of rotation; and
based on the torque curve, the wire diameter of the first spring, and the spring diameter of the first spring, determining a length of the first spring; wherein the wire diameter, the spring diameter, and the length of the first spring are selected to match the torque curve.

US Pat. No. 10,138,662

LOCKING APPARATUS FOR SLIDING DOOR

HYUNDAI MOTOR COMPANY, S...

1. A locking apparatus for a sliding door of a vehicle, the locking apparatus comprising:a window glass safety stopper and a hold-open lock striker sequentially provided in a body of the vehicle in an opening direction of the sliding door as the sliding door moves from a closed position to an open position;
a roller bracket provided at the sliding door;
a locking lever rotatably provided on the roller bracket and having a locking protrusion configured to be locked to the window glass safety stopper to limit movement of the sliding door in the opening direction and an engagement recess configured to be engaged with the hold-open lock striker to limit movement of the sliding door in the opening direction and a closing direction;
a first elastic member configured to bias the locking lever;
a window glass lever rotatably provided on the roller bracket, connected to a window glass provided at the sliding door via a first cable, and configured to interlock with the locking lever;
a second elastic member configured to bias the window glass lever; and
a connecting lever rotatably provided on the roller bracket, connected to a handle provided at the sliding door via a second cable, and configured to interlock with the locking lever.

US Pat. No. 10,138,624

ACTUATION APPARATUS

1. An actuation apparatus having a float valve fluid level sensor and a hydraulic actuator, wherein said actuation apparatus is adapted such that when a float of said float valve fluid level sensor rises above a predetermined level, said float valve fluid level sensor opens a float valve and causes fluid to flow to said actuator and causes said actuator to actuate, wherein said actuation apparatus is connected to a toilet having an auxiliary discharge valve, an auxiliary discharge path, and a bowl, and wherein said float rises and falls corresponding substantially to a rise and fall of contents of said bowl, and wherein said actuation of said actuator causes said auxiliary discharge valve to open such that said contents of said bowl may flow through said auxiliary discharge path.

US Pat. No. 10,138,621

HANDLE ASSEMBLY

KOHLER CO., Kohler, WI (...

1. A faucet handle assembly, comprising:a faucet handle;
a handle adaptor having a plurality of end stops extending radially outward therefrom, wherein the handle adaptor is configured to:
rotatably couple the faucet handle to a fluid control valve disposed within a valve body, and
rotatably couple to the valve body by the plurality of end stops; and
a bonnet including an inner ring having a plurality of locking features, wherein the bonnet is configured to be removably coupled to the valve body by the plurality of locking features.

US Pat. No. 10,138,619

UNIVERSAL EMBEDDED SYSTEM FOR SANITARY FAUCET COMPONENTS

FIR ITALIA S.P.A., Milan...

1. An embedding system for sanitary fittings, comprising three macro-groups adapted to be removably functionally associated with each other, said macro-groups comprising a first universal embedding macro-group with a manifold body, a second macro-group of functional components/groups and a third macro-group of aesthetic parts,wherein said second macro-group of functional components/groups comprises two single modular elements including a first element having a switching function and a second element having a mixing function, and each element being adapted to be mounted to said manifold body in any of four mounting positions, with each mounting position being rotated by 90° relative to another mounting position,
wherein said universal embedding macro-group is adapted to be installed at at least four installation positions, each installation position being rotated by 90° relative to at least one of the other four installation positions, thereby capable of providing four different finished product embodiments;
said manifold body having six ports comprising two inlets and four outlets disposed between a protective casing, said functional components/groups including at least one of shower groups, shower groups with switching devices, front outlet mixing groups and embedding mouth assemblies with a built-in drive.

US Pat. No. 10,138,615

BASE BODY OF ELECTRIC TRANSMISSION TOWER USING MICROPILE

KOREA ELECTRIC POWER CORP...

1. A base body of an electric transmission tower using a micropile, comprising:an anchor member coupled to a main pole member of the electric transmission tower;
a foundation member coupled to the anchor member and including a plurality of foundations; and
the micropile configured to fix the foundation member to a ground and compress the foundation member,
wherein the anchor member includes:
a plurality of anchor plates coupled to the foundation member and separated from each other, the plurality of anchor plates disposed inside the foundation member; and
an anchor pole configured to connect the plurality of anchor plates to each other and be attachably and detachably coupled to the main pole member,
wherein an upper end of the anchor pole passes through a base of the main pole member, the base disposed outside the foundation member and separated from the plurality of anchor plates, and
wherein at least one anchor plate of the plurality of anchor plates is disposed in a middle layer of the plurality of foundations.

US Pat. No. 10,138,611

PRESSURE DIFFERENTIAL OPEN DIKE EQUIPMENT AND OPEN DIKE SYSTEM TO LIMIT EFFECTS OF TIDE ON UPSTREAM AREAS

1. Open dike system comprising:a dike body having a first end and a second end and a first side and a second side;
a plurality of anchor feet, wherein the plurality of anchor feet are connected to or integral with a bottom surface of the dike body;
a first pillar connected to or integral with an upper surface along the first end or the first side of the dike body;
a second pillar connected to or integral with the upper surface of the dike body offset from and approximately parallel to the first pillar;
a first flap gate rotationally, vertically attached to the first pillar and disposed between the first and second pillars, wherein the first flap gate closes against a first extension in the second pillar; and
a means for opening and closing one or more flap gates, wherein the means for opening and closing the one or more flap gates opens and closes the first flap gate.

US Pat. No. 10,138,608

APPARATUS FOR REMOVING SNOW THROUGH LIQUEFACTION

DAEJI PRECISION INDUSTRIE...

1. An apparatus for removing snow through liquefaction, comprising:a snow suction means including a stirring part configured to forcibly crush and stir external snow and a suction part configured to forcibly suction the snow stirred in the stirring part;
a water spray means configured to spray water into the suction part to melt the snow suctioned by the snow suction means;
a storage part configured to store the water into which the snow is melted by the water spray means; and
a heating means located under the storage part and configured to apply heat to the water stored in the storage part, the heating means including
a burner in which a fuel is supplied and burned,
a first header which is horizontally disposed under the storage part to inject combustion heat from the burner,
a plurality of exhaust pipes of which one ends are connected to the first header to discharge the combustion heat,
a second header to which the other end of the exhaust pipe is connected to integrate exhaust heat, and
a heating part of which one end is connected to the second header to supply the exhaust heat around the snow suction means and also to discharge the exhaust heat to an outside,
wherein the heated water in the storage part is pumped and supplied to the water spray means.

US Pat. No. 10,138,606

EXPANSION JOINT COMPRISING A HYBRID POLYUREA-POLYURETHANE HEADER COMPOSITION

1. An expansion joint comprising:first and second adjacent structural members having a gap defined between said structural members, wherein said first and second adjacent structural members each comprise at least one surface;
a recess formed in the said surfaces of said first and second adjacent structural members;
a hybrid polyurea-polyurethane composition located within said recess of at least one of said first and second adjacent structural members, wherein said hybrid polyurea-polyurethane composition comprises the reaction product of at least one isocyanate, at least one polyol, at least one difunctional amine, and at least one trifunctional amine; and
a seal member extending across said gap and affixed to said first and second adjacent structural members by said hybrid polyurea-polyurethane composition.

US Pat. No. 10,138,605

RAILWAY TRACK SLEEPER SQUARING DEVICE AND SELF-PROPELLED MACHINE WHICH COMPRISES THIS DEVICE

FERROVIAL AGROMEN, S.A., ...

1. A railway track sleeper squaring device, characterised in that it comprises:at least a first and second positioning element adapted to be located between two consecutive sleepers and adapted to be located at opposite ends of the sleepers and parallel to the direction of the railway track, where these positioning elements can be extended in this direction;
a frame joined to the first and to the second positioning element;
a first and a second stops joined to the frame, where each stop comprises a first part and a second part arranged facing the first and the second positioning element, being configured in such a way that in use the first and second stops are located on the external face of the two end sleepers to be positioned and where at least one of the first or second stops can be extended in the direction parallel to the track; and
where the first and the second positioning element and the stop that can be extended are configured such that in their simultaneous extension to a pre-set value, they push the sleepers so as to square them.

US Pat. No. 10,138,602

FASTENING POINT, IN WHICH A RAIL FORMING PART OF A TRACK FOR RAIL VEHICLES IS MOUNTED ON A FOUNDATION

Vossloh-Werke GmbH, Werd...

1. A fastening point, in which a rail forming part of a track for rail vehicles is fixed to a foundation, the fastening point comprising:a bedplate arranged on a support surface of the foundation, the bedplate comprising a support surface formed on an upper side of the bedplate associated with the rail, a bearing surface formed on an underside of the bedplate associated with the foundation, as well as a through-opening leading from the underside to the upper side of the bedplate,
a spring element, which exerts an elastic holding-down force on the rail foot, and
a clamping screw, which braces the spring element against the bedplate, wherein the clamping screw is guided with its threaded shaft through the through-opening of the bedplate, and wherein
the clamping screw acts with its screw head against the spring element,
the clamping screw is screwed with a thread section of its threaded shaft into a thread provided in a region of the through-opening of the bedplate, and
a free space is provided in a region present in a direction of the foundation underneath the bedplate, in an extension of the through-opening of the bedplate, into which free space the threaded shaft of the clamping screw is adapted to be inserted via its free end.

US Pat. No. 10,138,600

FIBROUS PRODUCT AND METHOD OF PRODUCING FIBROUS WEB

METSA BOARD OYJ, Metsa (...

1. A method of producing a fibre web comprising an inner layer and two outer layers, the method comprising ozonizing fibre pulp, which consists of mechanical or chemi-mechanical pulp, foam-forming said ozonized fibre pulp, drying said foam-formed ozonized fibre pulp to form the inner layer, and arranging the dried inner layer between the two outer layers whereby the fibre web is formed.

US Pat. No. 10,138,597

WIRE

HI-LEX CORPORATION, Hyog...

1. An operating wire rope having a multiple strand structure, wherein:the multiple strand structure is composed of
a core strand composed of a plurality of element wires which are twisted together, and
a plurality of side strands disposed around the core strand, each of the side strands being composed of a plurality of element wires which are twisted together, the core strand and the side strands being twisted together;
a side element wire of the side strand includes a smooth surface at a portion located on an outer periphery of the operating wire rope, the smooth surface comprising a flat part which is provided facing radially outside of the operating wire rope at a part of the side element wire in a circumferential direction, the flat part extending along an axial direction;
an axial length of the smooth surface is 4.8 to 11.0 times a diameter of the side element wire; and
a pitch multiplying factor of the side strand is 7.0 to 12.0 times, the pitch multiplying factor being defined as a value obtained by dividing a strand pitch length of the side strand by an outer diameter of the operating wire rope.

US Pat. No. 10,138,588

CLOTHES DRYER VENTILATION SYSTEM

1. An item of ductwork comprising:a master duct, a damper, a filter assembly, and a vent;
wherein the damper, the filter assembly, and vent are attached to the master duct;
wherein the item of ductwork is adapted for use with a dryer;
wherein the dryer is located in a building;
wherein the dryer discharges exhaust air;
wherein the item of duct work routes the discharged exhaust air to an exhaust vent or into an interior of the building;
wherein the master duct is a tube;
wherein the master duct is further defined with a first end, a second end, a center axis; and a sidewall;
wherein the first end of the master duct is attached to the dryer;
wherein the master duct receives discharged exhaust air from the dryer;
wherein the second end of the master duct is attached to the exhaust vent;
wherein the master duct transports the discharged exhaust air to its final destination;
wherein the damper is a valve that is mounted within the master duct;
wherein the damper is further defined with an open mode and a closed mode;
wherein when the damper is in the open mode the discharged exhaust air flows unimpeded from the first end of the master duct to the second end of the master duct;
wherein when the damper is in a closed mode, the discharged exhaust air is diverted to the vent;
wherein the damper further comprises a baffle, a baffle mount, and a handle;
wherein the baffle is a plate that is mounted within the master duct;
wherein the baffle mount attaches the baffle to the master duct;
wherein the handle is attached to the baffle mount;
wherein the position of the baffle is adjustable;
wherein the handle adjusts the position of the baffle;
wherein the baffle directs a flow of the discharged exhaust air to the exhaust vent or into the interior of the building;
wherein the baffle mount comprises a first pivot and a second pivot;
wherein the first pivot connects the baffle to the sidewall of the master duct;
wherein the second pivot connects the baffle to the sidewall of the master duct;
wherein the baffle mount attaches the baffle to the master duct such that the first pivot and the second pivot create a center of rotation around which the baffle can rotate;
wherein the baffle mount attaches the baffle to the master duct such that the center of rotation runs through a center of the baffle;
wherein the baffle mount attaches the baffle to the master duct such that the center of rotation intersects perpendicularly through a center axis of the master duct.

US Pat. No. 10,138,587

HOUSEHOLD CLEANING APPLIANCE WITH A DISPENSING SYSTEM OPERABLE BETWEEN A SINGLE USE DISPENSING SYSTEM AND A BULK DISPENSING SYSTEM

Whirlpool Corporation, B...

1. A household cleaning appliance configured to execute a cleaning cycle on an article, comprising:a cabinet defining an interior;
a rotatable drum located within the interior and defining a treating chamber for receiving an article for treating and wherein a rotational axis of the rotatable drum is vertical; and
a dispensing system configurable to operate with either single use dispensing functionality or bulk dispensing functionality based on user selection; wherein
the dispensing system includes:
a single use dispensing chamber located within the cabinet, wherein the single use dispensing chamber is fluidly coupled to the treating chamber, and wherein the single use dispensing chamber stores a single dose of treating chemistry that the dispensing system dispenses to the treating chamber as part of the execution of the cleaning cycle;
a bulk dispensing chamber configured to store multiple doses of a liquid treating chemistry; and
a treating chemistry meter fluidly coupled with the bulk dispensing chamber and the single use dispensing chamber, wherein the treating chemistry meter is configured to control dosing of the treating chemistry from the bulk dispensing chamber to the single use dispensing chamber as part of the execution of the cleaning cycle;
wherein the treating chemistry meter is configured to dispense at least one of the multiple doses of the liquid treating chemistry into the single use dispensing chamber such that the single use dispensing chamber is provided with bulk dispensing functionality to define a bulk dispensing system.

US Pat. No. 10,138,580

NANOFIBER YARNS, THREAD, ROPE, CABLES, FABRIC, ARTICLES AND METHODS OF MAKING THE SAME

Multipure International, ...

1. A material comprising an assembly of two or more spun yarns twisted together to form a twisted pair, each of said yarns comprising:synthetic inorganic fibers, wherein a majority of said fibers: (a) are longer than 300 ?m, (b) have a diameter ranging from 0.25 nm and 700 nm, and (c) are substantially crystalline,
wherein said yarn has flexibility and a uniform number of said fibers as measured by a cross sectional cut, and
wherein said twisted pair is twisted while under a tension resulting in a pressure between the twisted pair ranging from 1 mPa and 30 TPa.

US Pat. No. 10,138,579

FIBER TOW TREATMENT APPARATUS AND SYSTEM

United States Council For...

1. A method of treating fiber tow, comprising:applying a nubbed roller to a first fiber tow having a first fiber tow size to produce a number of openings in the first fiber tow; and
via a pulling roller, immediately transferring the first fiber tow with the number of openings from the nubbed roller to a chopping station that includes the pulling roller and a chopper, wherein the chopper cooperates with the pulling roller to chop the first fiber tow, and wherein the step of transferring occurs after the step of applying without an intermediate step of processing therebetween; and
via the pulling roller and the chopper, chopping the first fiber tow with the number of openings to produce a second fiber tow having a second fiber tow size less than the first fiber tow size.

US Pat. No. 10,138,568

SEPARATION OF ALPHA EMITTING SPECIES FROM PLATING BATHS

International Business Ma...

1. A plating product fabrication method comprising:forming a first concentrate, the concentrate comprising a Tin (Sn) species and a trace amount of a Polonium (Po) species;
creating a circuit between a filtering anode and a filtering cathode; and
reducing the Po species from the concentrate by plating the Po species upon the filtering cathode.

US Pat. No. 10,138,567

APPARATUS AND METHOD FOR IONIC LIQUID ELECTROPLATING

United Technologies Corpo...

1. A method for coating at least a first surface of a workpiece with a metallic coating, the method comprising:electrolytically etching a first portion of the workpiece in a container holding an ionic liquid plating solution, the etching step comprising subjecting the workpiece to an anodic potential and subjecting a counter electrode to a cathodic potential to remove at least a portion of an applied displacement layer, thereby (i) accumulating ionic byproducts of the removed portion of the displacement layer in the ionic liquid plating solution in the container and (ii) exposing and activating the first surface;
electrodepositing the metallic coating onto the exposed and activated portion of the first surface without removing the workpiece from the container or the ionic liquid plating solution, the electrodepositing step comprising subjecting the counter electrode to an anodic potential and subjecting the workpiece to a cathodic potential to deposit coating donor material from the counter electrode onto the surface to be coated; and
during at least one of the etching step and the electrodepositing step, fluidly communicating a portion of the ionic liquid plating solution through a porous scrubber disposed in the ionic liquid plating solution in the container between the workpiece and the counter electrode, the scrubber having a plurality of metallic outer surfaces in contact with the ionic liquid plating solution to capture at least some of the accumulated ionic byproducts of the removed portion of the displacement layer from the ionic liquid plating solution;
wherein a portion of the ionic byproducts adhere to the metallic outer surfaces of the scrubber during at least the etching mode, thereby regenerating the ionic liquid plating solution in situ by removing at least a portion of the ionic byproducts therefrom without removing the ionic liquid plating solution from the container.

US Pat. No. 10,138,561

CERIUM CITRATE, METHOD OF MAKING AND CORROSION INHIBITOR COMPRISING CERIUM CITRATE

UNITED TECHNOLOGIES CORPO...

1. A method of making cerium citrate comprising combining cerium carbonate and citric acid at a temperature of 60 to 90° C. for 5 to 7 hours in an inert atmosphere and cooling and reacting for 8 to 12 hours to produce cerium citrate and carbon dioxide.

US Pat. No. 10,138,557

METHOD FOR METALIZING POLYMER SUBSTRATE AND POLYMER ARTICLE PREPARED THEREOF

BYD Company Limited, She...

1. A method for metalizing a polymer substrate, comprising:providing a polymer substrate having a base polymer and at least one metal compound dispersed in the base polymer, the base polymer comprising a polymer, the at least one metal compound having a formula ABmOn, wherein A comprises at least one element selected from columns 8-11 of periodic table of elements, B comprises at least one element selected from columns 4, 6-8 and 13 of periodic table of elements, O is oxygen, and m is one of 1 and 2, n is one of 2, 3, and 4, and m irradiating a surface of the polymer substrate with an energy beam such that a water contact angle of the surface of the polymer substrate is at least 120°; and
performing chemical plating on the surface of the polymer substrate.

US Pat. No. 10,138,556

PLATING METHOD, PLATING APPARATUS, AND STORAGE MEDIUM

TOKYO ELECTRON LIMITED, ...

1. A plating method of performing an electroless plating process to a recess formed in a substrate, the plating method comprising:a loading process of loading the substrate in which the recess is formed into a casing;
a plating process of supplying a plating liquid to the substrate and forming a combined plating layer which is a barrier film or a seed film, on an inner surface of the recess; and
a burying process of burying a wiring material into the recess on which the combined plating layer has been formed,
wherein the plating process includes a first plating process of supplying a first plating liquid to the substrate and forming a first plating layer; and a second plating process of supplying a second plating liquid to the substrate and forming a second plating layer on the first plating layer, and
a concentration of an additive contained in the first plating liquid is different from a concentration of an additive contained in the second plating liquid,
a thickness of the first plating layer formed on the inner surface of the recess is greater at an upper portion of the recess than at a lower portion of the recess,
a thickness of the second plating layer formed on the inner surface of the recess is greater at the lower portion of the recess than at the upper portion of the recess, and
a thickness of the combined plating layer including the first layer and the second layer is uniform regardless of positions within the recess.

US Pat. No. 10,138,553

VACUUM TREATMENT APPARATUS

EVATEC AG, Trubbach (CH)...

1. A vacuum treatment apparatus comprising:a vacuum treatment chamber (13, 73) to perform a desired workpiece treatment of a workpiece and with a rigid wall;
a vacuum transport chamber (1, 61);
a handling opening common to said vacuum treatment chamber and to said vacuum transport chamber;
a workpiece transport (5, 65) for handling a workpiece from said vacuum transport chamber through said handling opening and into said vacuum treatment chamber, said transport being drivingly movable along a movement path (S) extending from said vacuum transport chamber through said handling opening and in said vacuum treatment chamber;
a workpiece support adapted to support a workpiece in said treatment chamber, said vacuum treatment chamber (13, 73) comprising a workpiece treatment compartment (13T, 75T) for a workpiece to which a surface of a workpiece to be treated on said workpiece support is exposed for treatment, said vacuum treatment compartment being located on one side of said movement path (S) in said vacuum treatment chamber and being equipped with units to perform the workpiece treatment and a pumping compartment (13P, 75P) opposite said workpiece treatment compartment (13T, 75T) with respect to said movement path (S) in said vacuum treatment chamber;
a pumping port arrangement for said workpiece treatment compartment, said pumping port arrangement consisting of at least one pumping port in said pumping compartment;
a controllable seal (17, 17a, 109, 79, 87, 83, 85) within said treatment chamber and controllably sealing off or freeing a first gas flow communication between said vacuum transport chamber (1, 61) and said pumping port (18, 101) through said handling opening and being constructed so as to separate a pumping area from an area of said vacuum treatment chamber with which said pumping port is in a second gas flow communication when said first gas flow communication is sealed off.

US Pat. No. 10,138,551

SUBSTRATE PROCESSING APPARATUSES AND SYSTEMS

GES Associates LLC, Phoe...

17. A system for processing one or more substrates, the system comprising:an outer chamber;
a process chamber disposed within the outer chamber;
a substrate support disposed in the process chamber to hold one or more substrates;
at least one electrical resistance heater comprising a sinusoidal heating element having a plurality of peaks disposed to delineate an outer radius and a plurality of troughs disposed to delineate an inner radius; a cross-section width of the sinusoidal heating element being a first function of a radial position and a cross-section thickness of the sinusoidal heating element being a second function of the radial position so that the sinusoidal heating element provides a constant heat flux at the radial position and forms a constant spacing between facing side surfaces of the sinusoidal heating element wherein the radial position is a value that ranges from the inner radius to the outer radius, the at least one electrical resistance heater comprising pyrolytic graphite electrical contacts and pyrolytic graphite electrical adapters press-fit coupled thereto and a thermally deposited silicon carbide overcoating, the at least one electrical resistance heater being disposed between the outer chamber and the process chamber so as to heat the substrate support;
at least one Coanda effect gas injector disposed proximate a peripheral edge of the substrate support so as to provide a Coanda effect gas flow over the surface of the substrate support, the at least one Coanda effect gas injector having a gas entry port, a plenum, a gas flow channel, and a gas exit port; the gas exit port being in fluid communication with the plenum via the gas flow channel, the gas entry port being in fluid communication with the plenum, the gas flow channel being formed by at least one convex surface of the Coanda effect gas injector so as to produce a Coanda effect gas flow;
at least one secondary gas injector disposed so as to provide a gas flow to the process chamber; and
a rotary coupling connected with the substrate support for rotating the substrate support;
wherein the cross-section thickness of the sinusoidal heating element is:
t=2?ri2Gti/(2?r2G?Sr)
 where
t is the cross-section thickness of the sinusoidal heating element,
r is the radial position,
? is the mathematical constant pi,
ri is the inner radius of the sinusoidal heating element,
ti is an initial trial thickness,
G is a geometry factor equaling an angular width of the sinusoidal heating element between the peaks and troughs divided by an angular size of the at least one electrical resistance heater, and
S is the constant spacing between facing side surfaces of the sinusoidal heating element;
wherein the cross-section width of the sinusoidal heating element is:
w=2?Gr?S
 where
w is the cross-section width of the sinusoidal heating element,
r is the radial position,
? is the mathematical constant pi,
G is a geometry factor equaling an angular width of the sinusoidal heating element between the peaks and troughs divided by an angular size of the at least one electrical resistance heater, and
S is the constant spacing between facing side surfaces of the sinusoidal heating element.

US Pat. No. 10,138,550

FILM DEPOSITION METHOD AND AN APPARATUS

TOSHIBA MEMORY CORPORATIO...

1. A film deposition method deposit a film in a groove, comprising:determining a thickness of a film to be deposited in the groove at several reference points comprising,
determining a solid angle for the several reference points on a side surface of the groove by a calculating device;
determining the thickness of the film to be formed at the several reference points in a reference deposition time based on a deposition model defining a predetermined correlation between the solid angle and the thickness of the film formed in the reference deposition time by the calculating device, the deposition time includes a first deposition time and a second deposition time after the first deposition time, wherein the thickness during the first deposition time is determined at a first reference point that lies in a first region extending from an upper edge of the groove in a downward direction by applying a first correlation and a second reference point that lies in a second region below the first region by applying a second correlation, and the thickness during the second deposition time is determined at a third reference point that lies in a third region extending from an upper edge of the film to be deposited on the groove during the first deposition time in the downward direction by applying a third correlation, the upper edge of the film being higher than the upper edge of the groove, and a fourth reference point that lies in a fourth region below the third region by applying a fourth correlation;
determining a shape of the film to be deposited in a region in which the several reference points lies based on the determined thickness by the calculating device; and
depositing the film based on the determined shape on the side surface of the groove by chemical vapor deposition.

US Pat. No. 10,138,548

FILM THICKNESS MEASURING DEVICE, POLISHING APPARATUS, FILM THICKNESS MEASURING METHOD AND POLISHING METHOD

EBARA CORPORATION, Tokyo...

8. A film thickness measuring method for measuring a film thickness of a polishing target by, when eddy current formable in the polishing target is detected as an impedance by an eddy current sensor, receiving an input of the impedance and determining the film thickness from the input impedance, wherein when respective axes of a coordinate system having two orthogonal coordinate axes are associated with a resistance component and a reactance component of the impedance respectively, a point on the coordinate system which corresponds to the impedance forms at least a part of a circle, andwherein the film thickness measuring method comprises:
a step of calculating a tangent or angular degree of an intersection angle between a first straight line connecting a first point corresponding to the impedance for a film thickness of zero and a second point corresponding to the impedance for a non-zero film thickness and a diameter of the circle which passes through the first point; and
a step of determining the film thickness from the tangent or the angular degree.

US Pat. No. 10,138,547

SUBSTRATE CARRYING APPARATUS AND SPUTTERING DEVICE COMPRISING THE SAME

BOE TECHNOLOGY GROUP CO.,...

1. An apparatus for carrying a substrate, comprising:a vertical bearing plate having a side surface as a bearing surface, the bearing surface being provided at left and right sides thereof with a plurality of positioning clips for positioning the substrate from left and right ends of the substrate; and
an upper holding base provided at an upside of the bearing surface, the upper holding base being provided with a plurality of holders for holding the substrate, each of the holders comprising:
a fixed splint provided at the upper holding base;
a moving splint for forming a clamp with the fixed splint;
a rotation arm having a driving end and a swing end, the rotation arm being hinged, at a point between the driving end and the swing end, to an upper end of the fixed splint, the swing end being fixedly connected with an upper end of the moving splint; and
a rotation driver connected with the driving end of the rotation arm, the rotation driver being configured to cause the clamp formed by the moving splint and the fixed splint to close by pushing the driving end, and to cause the clamp formed by the moving splint and the fixed splint to open by pulling the driving end.

US Pat. No. 10,138,546

APPARATUS AND METHOD TO COAT GLASS SUBSTRATES WITH ELECTROSTATIC CHUCK AND VAN DER WAALS FORCES

Corning Incorporated, Co...

1. A method of vacuum depositing a coating on a surface of a glass substrate, the method comprising:disposing a carrier and a glass substrate on an electrostatic chuck (ESC), such that the carrier is between the glass substrate and the ESC to form a chucking assembly, wherein the carrier comprises opposing first and second surfaces, and the glass substrate comprises opposing third and fourth surfaces, and further wherein at least one of the second surface and the third surface comprises a surface roughness Ra of from about 0.1 nm to less than 0.6 nm;
forming a Van der Waals bond between the second and third surfaces of the carrier and the glass substrate; and
vacuum depositing a coating on the glass substrate.

US Pat. No. 10,138,544

SPUTTERING TARGET

SOLERAS, LTD., Biddeford...

1. A method for casting a reactive material PVD target, the method comprising the steps of:providing a mold defining an opening, the mold having a closed bottom portion, and a mandrel surrounded by an outer mold shell, the mandrel being hollow and thus having an inner wall;
placing a reactive material ingot into a reservoir assembled with the mold so as to be enclosed and sealed, the reservoir located above the mold so that molten reactive material to be cast into the mold flows into a top portion of the mold from above, and the reservoir being directly connected and sealed to a top portion of the mold;
forming a vacuum or inert atmosphere and melting the reactive material ingot in the reservoir;
heating the mold to above a casting temperature and forming a vacuum or inert atmosphere therein;
introducing molten reactive material from the reservoir into the opening of the mold; and
cooling the mold to form the reactive material PVD target.

US Pat. No. 10,138,543

METHOD OF ANALYZING GROWTH OF TWO-DIMENSIONAL MATERIAL

Samsung Electronics Co., ...

1. A method of analyzing growth of a two-dimensional material, the method comprising:forming a two-dimensional material layer on a substrate, the two-dimensional material layer including defects;
depositing detection material layers on the defects, the detection material layers including a dielectric substance, the dielectric substance being an inorganic material that is a nitride,
wherein the nitride is one of AlN, Si3N4, and HfN4; and one of
capturing an image of the two-dimensional material layer on which the detection material layers are deposited and processing the captured image, or
obtaining map coordinates of the detection material layers and processing the obtained map coordinates.

US Pat. No. 10,138,541

METHOD FOR PRODUCING SUBSTRATE WITH TRANSPARENT ELECTRODE, AND SUBSTRATE WITH TRANSPARENT ELECTRODE

Kaneka Corporation, Osak...

1. A method for manufacturing a substrate with a transparent electrode in which a transparent electrode layer is provided on a transparent film substrate,the method comprising:
a deposition step of forming the transparent electrode layer on the transparent film substrate by a sputtering method, the transparent electrode layer being formed of indium tin oxide; and
a crystallization step of crystallizing the transparent electrode layer, wherein
in the deposition step, roll to roll sputtering deposition is performed using a sputtering target containing a sintered body of a solid dispersion of indium oxide and tin oxide while a sputtering gas containing argon and oxygen is introduced into a chamber,
an introduction rate Q of the sputtering gas introduced into the chamber is 200 sccm to 1500 sccm, and a pressure P in the chamber is 0.2 to 0.6 Pa, and
an effective exhaust rate S determined from the introduction rate Q of the sputtering gas and the pressure P in the chamber in accordance with the following formula is 1200 to 5000 (L/second):
S(L/second)=1.688×Q(sccm)/P(Pa).

US Pat. No. 10,138,537

7XXX SERIES ALUMINUM ALLOY MEMBER EXCELLENT IN STRESS CORROSION CRACKING RESISTANCE AND METHOD FOR MANUFACTURING THE SAME

Kobe Steel, Ltd., Kobe-s...

1. A member, comprising:a pair of flanges; and
a web connected to the flanges, a thickness of the web being from 1.5 to 4.0 mm,
wherein
the member is made of an aluminum alloy extrusion that comprises
Zn in a content of from 3.0 to 8.0 percent by mass,
Mg in a content of from 1.0 to 2.5 percent by mass,
Cu in a content of from 0.05 to 2.0 percent by mass,
Ti in a content of from 0.005 to 0.2 percent by mass,
at least one element selected from the group consisting of
Mn in a content of from 0.01 to 0.3 percent by mass,
Cr in a content of from 0.01 to 0.3 percent by mass and
Zr in a content of from 0.01 to 0.3 percent by mass and Al,
the member has a portion subjected to a reversion treatment and crushing in a direction perpendicular to an extrusion direction of the aluminum alloy extrusion and
the member satisfies conditions as follows:
1.5t?R?10t
Y??0.1X+1.4
Y=?sr/?0.2
X=[Mg]+[Zn]
where
R represents an inside bend radius of the web at the portion after said crushing;
t represents the thickness of the web;
?sr represents a tensile residual stress of the web at the portion;
?0.2 represents a 0.2% yield stress of the member;
[Mg] represents a content of Mg; and
[Zn] represents a content of Zn.

US Pat. No. 10,138,531

INDUCTION HARDENING CONTROL SYSTEM

NETUREN CO., LTD., Tokyo...

1. An induction hardening control system that is connected to an induction hardening apparatus configured so that a high-frequency inverter is connected to a capacitor and a heating coil and that controls an induction hardening to a work placed in the vicinity of the heating coil, comprising:a hardening control unit that controls the induction hardening apparatus based on setup conditions data regarding the induction hardening apparatus;
a hardening monitoring unit that measures, as measurement data, an electric quantity in an electric circuit configured to include the high-frequency inverter, the capacitor, and the heating coil to monitor an induction hardening status; and
a data collecting unit that collects data from various sensors in the induction hardening apparatus obtained when the work is subjected to the induction hardening by the induction hardening apparatus based on the setup conditions data outputted from the hardening control unit and that collects the measurement data from the hardening monitoring unit to store the data collected from the various sensors and the measurement data so that the data collected from the various sensors and the measurement data are associated to each other,
wherein the induction hardening apparatus has a current transformer which has a primary coil and a secondary coil, the primary coil being connected to the high frequency inverter via the capacitor, the secondary coil being connected to the heating coil,
wherein the hardening monitoring unit measures an output current from the high-frequency inverter or a voltage at the heating coil as the measurement data, the output current measured by a current sensor electrically connected to a wire between the high-frequency inverter and the capacitor, the voltage measured by a voltage sensor connected to the heating coil,
wherein the hardening monitoring unit further comprises a signal processing unit that rectifies the output current and the voltage to calculate a first effective value and a second effective value and removes noises by filters and a determination unit that determines whether the calculated first effective value and the calculated second effective value are within predetermined threshold values, and
wherein the setup conditions data is data for setting an output intensity and an output time from the high-frequency inverter in the induction hardening apparatus.

US Pat. No. 10,138,530

METHOD FOR PRODUCING HIGH-STRENGTH GALVANNEALED STEEL SHEETS

JFE STEEL CORPORATION, T...

1. A method for producing high-strength galvannealed steel sheets, the method comprising:subjecting a steel sheet to an oxidation treatment, the steel sheet comprising C: not more than 0.3%, by mass %, Si: 0.1 to 2.5%, by mass %, Mn: 0.5 to 3.0%, by mass %, and Fe and incidental impurities, the oxidation treatment including heating the steel sheet in (i) an upstream stage at a temperature in the range of 400° C. to 750° C. in an atmosphere having an O2 concentration of not less than 1000 ppm by volume and a H2O concentration of not less than 1000 ppm by volume and (ii) a downstream stage at a temperature in the range of 600° C. to 850° C. in an atmosphere having an O2 concentration of less than 1000 ppm by volume and a H2O concentration of not less than 1000 ppm by volume;
then subjecting the steel sheet to reducing annealing, the reducing annealing including heating the steel sheet at a temperature in the range of 650° C. to 900° C. in an atmosphere containing 5% to 30% of H2, by vol %, 500 ppm to 5000 ppm of H2O, by volume, and a balance of N2 and incidental impurities; and
thereafter subjecting the steel sheet to a hot-dip galvanizing treatment and to an alloying treatment, the alloying treatment including treating the steel sheet at a temperature T (° C.) satisfying the following relationship for 10 to 60 seconds:
?50 log([H2O])+650?T??40 log([H2O])+680
where [H2O] represents the H2O concentration by volume ppm during the reducing annealing.

US Pat. No. 10,138,528

METHOD AND SYSTEM FOR LASER HARDENING OF A SURFACE OF A WORKPIECE

1. Method of laser hardening of a surface of a journal of a crankshaft, said journal comprising a surface area to be hardened, said surface area extending in a first direction parallel with an axis of rotation of the crankshaft and in a second direction corresponding to a circumferential direction of the journal, said surface area comprising at least one more heat sensitive subarea and at least one less heat sensitive subarea, said at least one more heat sensitive subarea including an area adjacent to an oil lubrication hole of the crankshaft, the method comprising:projecting a laser beam from a laser source onto said surface area, so as to produce an effective laser spot on said surface area, the effective laser spot being formed by scanning the laser beam on said surface area such that the effective laser spot defines a region having a shape larger than the laser beam on said surface area, said effective laser spot extending, in said first direction, across the major part of said surface area to be hardened, wherein the effective laser spot extends, in said first direction across more than 50% of the surface of the journal;
moving the surface of the crankshaft in said circumferential direction relative to the laser source, so as to subsequently project the effective laser spot onto different portions of said surface area in the circumferential direction;
said effective laser spot featuring a two-dimensional energy distribution operative to induce hardening of the surface;
wherein the method comprises dynamically adapting while moving the surface of the crankshaft in said circumferential direction said energy distribution so that said energy distribution is different in said less heat sensitive subarea than in said more heat sensitive subarea including the area adjacent to an oil lubrication hole, so as to avoid overheating of said area adjacent to an oil lubrication hole.

US Pat. No. 10,138,519

UNIVERSAL SANGER SEQUENCING FROM NEXT-GEN SEQUENCING AMPLICONS

Quest Diagnostics Investm...

1. A composition comprising:a first oligonucleotide that comprises, in 5? to 3? order,
(a) a first region suitable for use as a Sanger sequencing primer;
(b) a spacer that is between about 5 and about 15 nucleotides long; and
(c) a third region suitable for use as a next generation sequencing (NGS) primer, and
a second oligonucleotide that comprises, in 5? to 3? order,
(a) a first region that is substantially identical to the third region of the first oligonucleotide; and
(b) a second region that is suitable for use as a polymerase chain reaction (PCR) primer to amplify a target nucleotide sequence,
wherein the third region of the first oligonucleotide and the first region of the second oligonucleotide have a melting temperature (Tm) that is at least about 5° C. higher than the Tm of the second region of the second oligonucleotide,
wherein the total length of the spacer and the first and second regions of the second oligonucleotide is at least about 45 nucleotides (nt) long,
wherein the third region of the first oligonucleotide and the first region of the second oligonucleotide are selected from Table 2, and
wherein the third region of the first oligonucleotide and the first region of the second oligonucleotide do not include any sequence that is specific to the target nucleotide sequence.

US Pat. No. 10,138,497

AGENTS FOR IMPROVED DELIVERY OF NUCLEIC ACIDS TO EUKARYOTIC CELLS

Molecular Transfer, Inc.,...

1. A compound having the structure (II):
wherein each R1 independently is C1-C23 alkyl, C1-C23 alkenyl, (CO)C1-C23 alkyl, or —(CO)C1-C23 alkenyl;
each R2 independently is C1-C6 alkyl, or C1-C6 alkenyl, optionally interrupted by O;
each R3 independently is H, C1-C6 alkyl, C1-C6 alkenyl, C2-C6 alkynyl, C3-C7 cycloalkyl, C3-C7 cycloalkyl-C1-C6 alkyl, C5-C7-cycloalkenyl, C5-C7-cycloalkenyl-C1-C6 alkyl, —(CH2)mNR6(CH2)nNHR7, —(CH2)2-6NHR7, —(CH2)3-6NHC(?NH)NH2, ((CH2)mOx)y(CH2)zOxR8, or —(CH2)0-3Het;
each R4 independently is H, C1-C6 alkyl, or C1-C6 alkenyl;
each R5 independently is H, an amine protecting group, —(CH2)mNR6(CH2)nNHR7, —(CH2)2-6NHR7, —(CH2)3-6NHC(NH)NH2, —(CO)C1-C23 alkyl, —(CO)C1-C23 alkenyl, or a peptide containing 1-20 amino acid residues;
each m independently is 2-5,
each n independently is 2-5,
each x independently is 0 or 1,
y is 0-2,
z is 1-6
R6 and R7 independently are H, an amine protecting group, —(CO)C1-C23 alkyl, or —(CO)C1-C23 alkenyl;
R8 is H, C1-C6 alkyl, or C1-C6 alkenyl
and
Het is a 5-7 membered monocyclic basic heterocycle, or an 8-11 membered bicyclic basic heterocycle.

US Pat. No. 10,138,478

ANTIBODY LIBRARIES

Adimab, LLC, Lebanon, NH...

1. A method of making a library comprising synthetic polynucleotides that encode an antibody heavy chain containing at least about 104 unique antibody CDRH3 amino acid sequences, wherein each of the polynucleotides encoding the at least about 104 unique antibody CDRH3 amino acid sequences has an antibody CDRH3 amino acid sequence represented by the following formula:[TN1]-[DH]-[N2]-[H3-JH],
the method comprising:
(a) providing a theoretical segment pool containing TN1, DH, N2, and H3-JH segments, wherein, the DH segments are provided according to the following steps:
(i) obtaining a set of polynucleotide sequences of human IGHD genes and alleles;
(ii) progressively deleting one or more nucleotide bases from the polynucleotide sequences of (i) on either or both of the 5? and 3? ends;
(iii) systematically adding 0, 1 and/or 2 or more nucleotides to the 5? and/or 3? ends of the polynucleotide sequences from (ii);
(iv) translating the polynucleotide sequences of (iii) and selecting unique amino acid sequences to thereby provide the DH theoretical segment pool;
(b) providing a reference set of preimmune CDRH3 sequences having sequence diversities and length diversities similar to naturally occurring human antibody sequences before these sequences have undergone negative selection and/or hypermutation;
(c) utilizing combinations of the TN1, DH, N2, and H3-JH segments contained in the theoretical segment pool of (a) to identify the closest match(es) to each CDRH3 sequence in the reference set of (b);
(d) selecting segments from the closest match(es) identified in step (c) for inclusion in a library comprising synthetic polynucleotides that encode an antibody heavy chain; and
(e) synthesizing the synthetic polynucleotides that encode an antibody heavy chain;
wherein the diversity of the polynucleotides encoding the at least about 104 unique antibody CDRH3 amino acid sequences is created by polynucleotides having CDRH3 sequences that are different from the CDRH3 sequences of other polynucleotides; and
wherein the antibody heavy chain is a variable domain with framework (FRM) and complementary determining regions (CDR) comprising FRMH1-CDRH1-FRMH2-CDRH2-FRMH3-CDRH3-FRMH4.

US Pat. No. 10,138,458

MAGNETIC LYSIS METHOD AND DEVICE

Akonni Biosystems, Inc., ...

1. A device for lysing cells, comprising:a chamber, wherein inside of the chamber contains a magnetic stir element and a plurality of beads, wherein the chamber is dimensioned to allow rotation of the magnetic stir element inside the chamber and wherein the chamber is placed on a surface; and
a magnet in the proximity of the chamber and not below the chamber, wherein the magnet is located above the bottom of the chamber and produces a varying magnetic field by rotating the magnet along an axis that is located above the bottom of the chamber and is parallel to the surface the chamber is placed on or the magnet is located on a side of the chamber, and produces a varying magnetic field by rotating the magnet along an axis that is located on the side of the chamber, wherein the axis passes through the center of the magnet, and wherein the chamber is in operational range of the varying magnetic field such that motions of the magnet stir element and the plurality of beads inside of the chamber are driven by the varying magnetic field.

US Pat. No. 10,138,455

INCUBATOR CHAMBER

1. An incubator chamber configured to provide an atmosphere-controlled environment, comprising:a base, a lid, and a clamp, wherein the base and lid define an interior space when coupled together;
wherein the base comprises a first flange comprising an indentation sized and dimensioned to receive a sealing ring;
wherein the base further comprises a gas distribution port coupled with a gas inlet and a gas outlet, and wherein the gas distribution port is fluidly coupled with a gas distribution portion having an upwardly slanted ramp, such that the gas distribution portion disrupts a flow of a gas from the gas inlet into the interior space;
first and second trays disposed within the interior space;
wherein the first tray comprises a bottom portion having a plurality of legs disposed about a perimeter of the first tray, wherein the legs extend downwardly from the bottom portion of the first tray, and wherein the plurality of legs are each sized to be placed between a pair of upwardly extending ribs of the base to prevent rotation of the first tray with respect to the base;
wherein the second tray comprises a bottom portion having a second plurality of legs disposed about a perimeter of the second tray, which are sized and dimensioned to mate with an upward projection of the first tray, such that the second tray is stably stacked on top of the first tray by the second plurality of legs;
wherein the lid comprises a second flange sized and dimensioned to mate with at least one of the first flange and the sealing ring of the base; and
wherein the clamp comprises (a) an inner perimeter cavity sized and dimensioned to concurrently receive at least a portion of the first flange and at least a portion of the second flange, and (b) a levered locking mechanism that is configured to tighten the clamp about the at least the portion of the first flange and the at least the portion of the second flange.

US Pat. No. 10,138,454

CULTURE CONTAINER

NISSHA PRINTING CO., LTD....

1. A culture container comprising:a transparent container main body having a recessed part configured to contain a culture solution, the recessed part including a bottom part and a tubular part;
a transparent presser member that is removably fitted onto an upper side of the recessed part, the presser member having
a lower-surface part that makes contact with an upper surface of the culture solution in a fitted state, in which the presser member is fitted to the container main body, to press the upper surface of the culture solution, and
a tubular part having a lower end connected an outer circumferential edge of the lower-surface part and an outer circumferential surface proximately opposing an inner circumferential surface of the tubular part of the recessed part, the tubular part opening upward to directly and entirely expose an upper surface of the lower-surface part outside of the culture container through an opening of the tubular part such that the culture solution is observable from the outside of the culture container through the lower-surface part in the fitted state; and
a bubble-discharge passage that is formed by the outer circumferential surface of the tubular part of the presser member and the inner circumferential surface of the tubular part of the recessed part, the outer circumferential surface of the tubular part of the presser member facing the inner circumferential surface of the tubular part of the recessed part, the bubble-discharge passage enabling discharge of bubbles in the culture solution to an exterior.

US Pat. No. 10,138,453

CELL CULTURE ARRAY SYSTEM FOR AUTOMATED ASSAYS AND METHODS OF OPERATION AND MANUFACTURE

EMD Millipore Corporation...

1. A microfluidic cell culture system integrated into a standard well plate, the microfluidic cell culture system comprising:a medium inlet reservoir fluidically connected to a plurality of microfluidic medium channels; a plurality of cell culture areas each located at an end of a cell culture channel;
said cell culture channel having a cell inlet opening fluidically connected to a cell inlet/medium outlet reservoir for introducing cells to said plurality of cell culture areas and for removing media;
a first well in communication with the medium inlet reservoir acting as a medium inlet; a second well in communication with the cell inlet/medium outlet reservoir acting as a cell inlet/medium outlet;
a third well acting as a viewing well for the plurality of cell culture areas;
a perfusion barrier between said plurality of cell culture areas and said plurality of microfluidic medium channels, said perfusion barrier containing a plurality of perfusion passages;
such that fluid introduced into said medium inlet reservoir must pass through said perfusion barrier before reaching said cell inlet/medium outlet reservoir; wherein a plurality of said perfusion passages are substantially narrower than cells to be cultured.

US Pat. No. 10,138,452

OBJECT-HOLDING DEVICE

YAMAHA HATSUDOKI KABUSHIK...

1. An object-holding device, comprising:a container configured to store a liquid and having an upper opening for charging an object into the stored liquid, and a bottom wall;
a plate having an upper surface and a lower surface and immersed into the liquid in a state in which the lower surface is spaced away from the bottom wall of the container, the plate including one or a plurality of holding portions arranged on the upper surface side and configured to carry the object, and a through hole formed at a position at which, the holding portion is arranged, and passing through the holding portion from the upper surface to the lower surface; and
a dispersing mechanism configured to form, in the through hole, a liquid flow which flows from the lower surface side toward the upper surface side to raise the object carried on the holding portion, wherein
the container includes:
a tubular inner peripheral wall including an upper end portion configured to define the upper opening, and a lower end portion configured to hold a peripheral edge of the plate;
a tubular outer peripheral wall including an upper edge portion continuously provided to the inner peripheral wall and a lower edge portion continuously provided to the bottom wall; and
a closed region that the inner peripheral wall, the outer peripheral wall, the bottom wall, and the plate form, and in a state in which the container stores the liquid so that a liquid surface of the liquid is positioned above the plate, the through hole is closed by the liquid retained on the plate such that the closed region becomes a sealed region; and
wherein
the dispersing mechanism forms the liquid flow by generating a pressurization force to the liquid surface in the closed region,
the closed region is formed with a space in which air is retained, and
the dispersing mechanism includes a pressure regulator configured to pressurize the space.

US Pat. No. 10,138,451

CELL CULTURE DISH SUPPORTING SIMULTANEOUSLY JUXTAPOSED AND SEPARATED CULTURES

1. A cell or tissue culture assembly for assessing signal communication of physically separated cell or tissue cultures, the cell or tissue culture assembly made of non media-permeable material and having a base and a plurality of separate juxtaposed side-by-side wells having common interior well walls preventing physical contact or movement of chemical factors between the separated cell or tissue cultures, the walls having different heights and defining an outer “surround” cell or tissue culture and one or more inner “center” cell or tissue cultures to enable contained cell or tissue communication between the well spaces, the wells configured to comprise two or more cell or tissue cultures, the wells permitting signal communication between the cells or tissues situated within said wells.

US Pat. No. 10,138,445

CLEANING PRODUCT

1. A cleaning product comprising a spray dispenser and a cleaning composition suitable for spraying, the composition housed in the spray dispenser wherein the composition comprises:i. about 5% to about 15% by weight of the composition of a surfactant system comprising:
ii. about 40% to about 90% by weight of the surfactant system of a non-ionic surfactant;
iii. about 10 to about 60% by weight of the surfactant system of a co-surfactant selected from anionic, amphoteric, zwitteronic and mixtures thereof;
iv. a glycol ether solvent selected from the group consisting of glycol ethers of Formula I: R 1O(R2O)nR3, Formula II: R4O(R5O)nR6 and mixtures thereof
wherein
R1 is a linear or branched C4, C5 or C6 alkyl or phenyl, R2 is ethyl or isopropyl,
R3 is hydrogen or methyl and n is 1, 2 or 3
R4 is n-propyl or isopropyl, R5 is isopropyl, R6 is hydrogen or methyl and n is 1, 2 or 3;
v. an alkanol amine; and
vi. bicarbonate.

US Pat. No. 10,138,437

WATER-SOLUBLE LUBRICANT OIL

SANYO CHEMICAL INDUSTRIES...

1. A water-soluble lubricating oil, comprising:a water-soluble base (A) comprising at least one polyether (A1),
a corrosion inhibitor (B), and
an antioxidant (C);
wherein the polyether (A1) comprises a polyether (A1-1) represented by formula (1),

wherein R1 is hydrogen or a hydrocarbon group having a valence of k and 1 to 12 carbon atoms; A1 is an ethylene group; R2 is hydrogen or a hydrocarbon group having 1 to 8 carbon atoms; k is an integer of 1 to 6; and j is an integer to allow the polyether (A1-1) to have a number average molecular weight of 62 to 8,000, and
wherein the corrosion inhibitor (B) comprises at least one corrosion inhibitor selected from the group consisting of a triethanolamine and a cyclohexylamine EO adduct,
wherein the water-soluble lubricating oil contains the polyether (A1) in an amount of 88.0 to 98.9% by weight, the corrosion inhibitor (B) in an amount of 1.0 to 10.0% by weight, and the antioxidant (C) in an amount of 0.1 to 2.0% by weight, based on the total weight of the polyether (A1), the corrosion inhibitor (B), and the antioxidant (C), and
wherein when the water-soluble lubricating oil is measured by a pendant-drop method using a 0.1% by weight aqueous solution of the water-soluble lubricating oil, the water-soluble lubricating oil has a surface tension of 31 mN/m or higher.

US Pat. No. 10,138,436

SYSTEM AND METHOD FOR CONVERTING FOOD WASTE INTO FUEL

KOREA INSTITUTE OF CIVIL ...

1. A system for converting food waste into a fuel product and a methane gas by thermally decomposing the food waste, comprising:a food waste storage tank in which food waste collected from a region is stored;
a plurality of solar concentrators configured to collect a sunlight and concentrate the sunlight on a plurality of predetermined region;
a plurality of thermal decomposition reactors, wherein each thermal decomposition reactor is disposed in a predetermined region on which the sunlight is concentrated by a corresponding solar concentrator of the plurality of solar concentrators and is configured to discharge the fuel product and the methane gas produced through thermal decomposition of the food waste;
a transferring device configured to transfer the food waste to the plurality of thermal decomposition reactors from the food waste storage tank, wherein a transfer speed of the transferring device is controllable to provide the food waste to each thermal decomposition reactor in an amount that can be treated by a single associated solar concentrator;
a controller, coupled to the solar concentrators, the thermal decomposition reactors, and the transferring device, wherein the controller is configured to control the transfer speed of the transferring device, a driving of the plurality of solar concentrators, and a thermal decomposition reaction in the plurality of thermal decomposition reactors;
a plurality of fermenters, wherein each fermenter is disposed in a region at a front end of a corresponding thermal decomposition reactor of the plurality of thermal decomposition reactors and is configured to temporarily contain and ferment the food waste transferred from the food waste storage tank before provision to the corresponding thermal decomposition reactor; and
a collecting duct configured to collect the methane gas generated from the plurality of thermal decomposition reactors, wherein the methane gas is separated and collected from the fuel product,
wherein the plurality of thermal decomposition reactors and the plurality of fermenters are formed to be sealed to remove an odor,
wherein each thermal decomposition reactor is configured to discharge the food waste thermally decomposed through the region in which the corresponding fermenter is disposed, so to provide thermal energy to ferment the food waste contained in the corresponding fermenter.

US Pat. No. 10,138,433

METHOD AND APPARATUS FOR PURIFYING A MIXTURE COMPRISING OIL AND WAX

Sulzer Chemtech AG, Wint...

1. A method for fractionating a crude mixture comprising at least one oil and at least one wax, which comprises the following steps:(a) mixing the crude mixture with a solvent to obtain a crude solvent-mixture,
(b) carrying out at least one crystallization stage with the solvent-mixture obtained in step (a) to prepare a first fraction containing dewaxed oil and a second fraction containing slack wax,
(c) carrying out at least one crystallization stage with the second fraction obtained in step (b) in a layer crystallizer, wherein to the second fraction prior to the crystallization in step (c) no solvent or at most 100% by weight of solvent relative to the weight of the second fraction are added, to prepare a third fraction containing hard wax having an oil content of at most 1.5% by weight and a fourth fraction containing soft wax having an oil content of more than 1.5% by weight and
(d) circulating at least a part of the fourth fraction into at least one of the at least one crystallization stage of step (b).

US Pat. No. 10,138,423

RESVERATROL-BASED FLAME RETARDANT MATERIALS

International Business Ma...

1. A process comprising forming a resveratrol-based flame retardant small molecule by chemically reacting a resveratrol molecule with a phosphonate molecule that includes a chloride group and a terminal functional group, the terminal functional group selected from the group consisting of: an epoxide group, a lactone group, an amine group, and a carboxyl group.

US Pat. No. 10,138,421

HOT MELT INTUMESCENT MATERIALS FOR FIRE PROTECTION

3M INNOVATIVE PROPERTIES ...

1. A free-standing solid intumescent material comprising:(a) 30 wt % or less, based on total weight of the intumescent material, of a hot melt thermoplastic or elastomeric resin, wherein the hot melt thermoplastic or elastomeric resin has
a Tm of 130° C. or lower;
a Tg of 130° C. or lower; and
a viscosity of 1000-100,000 poise at 100° C.-170° C. and 100-1,000,000 poise at 200° C.-300° C.;
(b) 0.5-50 wt % of a reinforcing material comprising fibers blended into the resin, the fibers having an aspect ratio of at least 100;
(c) 5-25 wt % of an inorganic filler; and
(d) an intumescent component comprising 5-20 wt % of a charring agent, 25-55 wt % of a charring catalyst, and 5-20 wt % of a blowing agent,
wherein the free-standing solid intumescent material is formed by a dry hot-melt process and is capable of acting as a fireproofing material.

US Pat. No. 10,138,419

NEAR-IR EMITTING CATIONIC SILVER CHALCOGENIDE QUANTUM DOTS

1. A near-IR emitting silver chalcogenide quantum dot with a mixed coating, wherein the silver chalcogenide comprises a silver cation source and a sulfide source, wherein the silver chalcogenide is cationic, wherein the silver chalcogenide is one or more selected from a group consisting of silver sulfide, silver selenide, and silver telluride; wherein the mixed coating comprises at least two types of coating materials, wherein both of the coating materials bind to a silver chalcogenide surface, and the first type of the coating material is a macromolecule selected from the group of polymers consisting of polyethyleneimine, poly dimethylaminoethyl methacrylate, poly amido amine dendrimer, dendrimers with amine end groups and chitosan, and the second type of the coating material is selected from the group consisting of thiolates, carboxylates and amines.

US Pat. No. 10,138,418

HYDRAULIC FRACTURING COMPOSITION, METHOD FOR MAKING AND USE OF SAME

BAKER HUGHES, A GE COMPAN...

1. A hydraulic fracturing composition comprising:a superabsorbent polymer in an expanded state and configured to break in response to contact with a breaker, the polymer having internal crosslinks derived from ethyleneglycol diacrylate, polyethyleneglycol diacrylate, trimethylopropane trimethacrylate, ethoxylated trimethylol triacrylate, ethoxylated pentaerythritol tetracrylate, or a combination comprising at least one of the foregoing but no intra-particle crosslinks; the superabsorbent polymer including a repeat unit derived from an acrylate, an acrylamide, a vinylpyrrolidone, a vinyl acetate, a 2-acrylamide-2-methylpropanesulfonic acid, an acrylic acid salt, or a combination thereof;
a plurality of proppant particles disposed in the superabsorbent polymer prior to release of the plurality of proppant particles from the superabsorbent polymer in response to breaking the superabsorbent polymer;
a fluid to expand the superabsorbent polymer into the expanded state; and
a breaker, the superabsorbent polymer and the breaker being selected such that the breaker reacts with the superabsorbent polymer to break a bond in a polymer chain of the super absorbent polymer, a bond in a crosslink of the superabsorbent polymer, a bond between the crosslink and the polymer chain, or a combination thereof.

US Pat. No. 10,138,413

PROMOTERS FOR PEROXIDES IN AQUEOUS TREATMENT FLUIDS

Arkema Inc., King of Pru...

1. An aqueous treatment fluid consisting essentially of:(a) a mixture or dispersion of water,
(b) viscosifying polymer which is water-soluble or water swellable polymer selected from the group consisting of:
(i) polysaccharides crosslinked with at least one crosslinker selected from the group consisting of borate, zirconium, aluminum, titanium, and chromium organometallic crosslinkers,
(ii) polysaccharides selected from the group consisting of guar gum, HPG (hydroxypropylguar), CMG (carboxymethylguar), CMHPG (carboxymethylhydroxypropylguar), and combinations thereof, and
(iii) underivatized guar, starches, cellulose, derivatized guars, polyacrylamides, polyacrylates, functionalized polyacrylamide polymers, acrylamide methyl propane sulfonic acid copolymers, polyvinyl alcohol, polyvinyl pyrrolidones, maleic anhydride methyl vinyl ether copolymers, polyethylene oxides and combinations thereof,
(c) at least one peroxide breaker selected from the group consisting of 2,5-dihydroperoxy-2,5-dimethylhexane; cumene hydroperoxide; t-butyl hydroperoxide; t-amyl hydroperoxide; t-octyl hydroperoxide; 1,1,3,3-tetramethylbutyl hydroperoxide; para-menthane hydroperoxide; diisopropylbenzene monohydroperoxide; diisopropylbenzene dihydroperoxide; 2,4-pentanedione peroxide; methyl ethyl ketone peroxide, methyl isobutyl ketone peroxide and combinations thereof,
(d) at least one promoter selected from the group consisting of thiosulfate salts, sulfite salts, bisulfite salts, erythorbate salts, isoascorbate salts, and combinations thereof, and optionally:
(e) at least one buffering agent or buffer system,
(f) at least one proppant, and/or
(g) one or more additives selected from the group consisting of surfactants and inert fillers,
wherein the aqueous treatment fluid is essentially free of added amine.

US Pat. No. 10,138,410

METHOD AND SYSTEM FOR THE ENHANCED RECOVERY OF OIL, USING WATER THAT HAS BEEN DEPLETED IN IONS USING MAGNETIC PARTICLES

1. A method for recovering crude oil from a hydrocarbon-bearing reservoir by water flooding, the method comprises the steps of:(i) providing a water source;
(ii) depleting one or more ions from the water source by contacting the water source with a superparamagnetic or paramagnetic particle capable of binding the one or more ions present in the water source thereby providing a capturing mixture;
(iii) removing the ions bound to the superparamagnetic or paramagnetic particles from the capturing mixture by applying a magnetic field thereby providing a depleted water;
(iv) pumping the depleted water into one or more connecting injection well(s) in an oil field thereby pushing the crude oil towards one or more production well(s); and
(v) recovering the crude oil from the one or more production well(s),
wherein the superparamagnetic or paramagnetic particles are functionalized with a moiety capable of specifically binding the one or more ions present in the water source; and
wherein the functionalization adapted to specifically bind the superparamagnetic or paramagnetic particles to the one or more ions consists of functionalization with an ion sequester selected from the group consisting of diamines, porphyrins, triazole-containing molecules, nucleic acids, RNA, DNA, EDTA, EGTA, DTPA and BAPTA.

US Pat. No. 10,138,401

METHOD OF BONDING TO FOIL

Rohm and Haas Company, C...

1. A waterborne adhesive composition comprising(i) an aqueous medium
(ii) one or more isocyanate compounds dispersed in said aqueous medium, and
(iii) one or more functional silane compounds dispersed in said aqueous medium,
wherein said isocyanate compound comprises a mixture of one or more hydrophilically modified isocyanate trimers and one or more urethane pre-polymers,
wherein the hydrophilically modified isocyanate trimers have the structure

wherein the three R groups are the same as each other, wherein the three R groups are aliphatic, and wherein G is an organic group that contains a hydrophilic group selected from the group consisting of hydrophilic alkylene oxide groups, anionic sulfate groups, and anionic carboxylate groups,
wherein the urethane pre-polymer is the reaction product of one or more polyisocyanates with one or more polyols or one or more polyamine or a mixture thereof, with a molar excess of polyisocyanates;
wherein said adhesive composition contains no colorant.

US Pat. No. 10,138,394

AIR-WATER BARRIER SILICONE COATINGS

CSL Silicones Inc., Guel...

1. A one-part room temperature vulcanizable (RTV) poly(diorganosiloxane) composition comprising:(a) about 10-70 wt % of a poly(diorganosiloxane) of Formula I:

wherein
R1 and R2 are each independently C1-8alkyl, C2-8alkenyl or C6-10aryl; and
n has an average value such that the viscosity of the poly(diorganosiloxane) of Formula I is from about 40,000-90,000 cP at 25° C.;
(b) about 5-40 wt % of a poly(diorganosiloxane) of Formula II:

 wherein
R3 and R4 are each independently C1-salkyl, C2-8alkenyl or C6-10aryl;
R5a, R5b, R5c, R5d, R5e and R5f are each independently C1-8alkyl, C2-8alkenyl or C6-10aryl; and
q has an average value such that the viscosity of the poly(diorganosiloxane) of Formula II is from about 500-50,000 cP at 25° C.;
(c) about 0.5-25 wt % of an amorphous silica reinforcing filler;
(d) about 2-15 wt % of at least one cross-linking agent of Formula III:
(X)4-m—Si—R6m  (III),
wherein
R6 is C1-8alkyl, C2-8alkenyl or C6-10aryl;
m is 0, 1 or 2; and
X is a hydrolysable ketoximino-containing group of Formula IV:

wherein R7a and R7b are each independently C1-8alkyl, C2-8alkenyl or C6-10aryl;
or
X is a hydrolysable group of Formula V:

wherein R8a, R8b and R8c are each independently H, C1-8alkyl, C2-8alkenyl or C6-10aryl;
(e) about 0.2-5 wt % of an adhesion agent of Formula VI:

wherein
R9 and R10 are each independently C1-8alkyl, C2-8alkenyl or C6-10aryl;
R11 is C1-10alkyl, C2-10alkenyl or C6-10aryl, optionally substituted with one or more organofunctional groups;
p is 0 or 1; and
(f) about 0.01-2 wt % of an organometallic condensation catalyst, wherein the metal of the organometallic condensation catalyst is selected from tin, titanium, zirconium, boron, zinc and bismuth; and
(g) about 1-40 wt % of a solvent,
wherein each alkyl, alkenyl and aryl group in the compounds of Formula I, II, III, IV, V and VI is optionally fluoro-substituted, and
wherein the composition has a viscosity suitable for application by spraying as a uniform and continuous film that produces a cured film that passes a crack bridging test performed according to ASTM C1305, and the composition has properties suitable for a silicone elastomeric air-water barrier coating for building materials.

US Pat. No. 10,138,392

NON-FLUORINATED URETHANE BASED COATINGS

THE CHEMOURS COMPANY FC, ...

1. A composition comprising an organic solution or aqueous dispersion of a compound having no unreacted isocyanate groups, said compound prepared by the process comprising:(i) reacting (a) at least one isocyanate group-containing compound selected from isocyanate, diisocyanate, polyisocyanate, or mixture thereof, and (b) at least one isocyanate-reactive compound selected from formula (Ia) or (Ib):

wherein each R is independently a —H; —R1; —C(O)R1; —(CH2CH2O)n(CH(CH3)CH2O)mR2;or —(CH2CH2O)n(CH(CH3)CH2)mC(O)R1;each n is independently 0 to 20;each m is independently 0 to 20;m+n is greater than 0;each R1 is independently a linear or branched alkyl group having 5 to 29 carbons optionally comprising at least 1 unsaturated bond;each R2 is independently —H, or a linear or branched alkyl group having 6 to 30 carbons optionally comprising at least 1 unsaturated bond;or a mixtures thereof,provided that when the compound is of Formula (Ia) then at least one of R or R2 is —H and at least two of R are chosen from —C(O)R1; —(CH2CH2O)n?(CH(CH3)CH2O)m?R2;or —(CH2CH2O)n?(CH(CH3)CH2O)m?C(O)R1;each R3 is independently a —H; —R1; —C(O)R1; —(CH2CH2O)n?(CH(CH3)CH2O)m?R2;or —(CH2CH2O)n?(CH(CH3)CH2)m?C(O)R1;each R4 is independently —H, a linear or branched alkyl group having 6 to 30 carbons optionally comprising at least 1 unsaturated bond, or combinations thereof; —(CH2CH2O)n?(CH(CH3)CH2O)m?R2;or —(CH2CH2O)n?(CH(CH3)CH2O)m?C(O)R1;each n? is independently 0 to 20;
each m? is independently 0 to 20;
m?+n? is greater than 0; and
provided when the compound is Formula (Ib), then the compound is mono-substituted, di-substituted, or tri-substituted with alkyl groups, and at least one R2, R3 or R4 is a —H.

US Pat. No. 10,138,387

ACTIVE ENERGY RAY CURABLE COMPOSITION, ACTIVE ENERGY RAY CURABLE INK, COMPOSITION STORED CONTAINER, TWO DIMENSIONAL OR THREE DIMENSIONAL IMAGE FORMING APPARATUS, IMAGE FORMING METHOD, CURED MATERIAL, AND PROCESSED PRODUCT

Ricoh Company, Ltd., Tok...

1. An active energy ray image forming apparatus comprising:a head;
a heating mechanism disposed inside the head; and
a storing part comprising an ink composition comprising a non-polymerizable synthetic resin and a mono-functional monomer comprising a single unsaturated ethylene double bond,
wherein
the heating mechanism is heated to 60° C. when ink is discharged, and
a viscosity at 25° C. of the ink composition is from 3 to 40 mPa·s,
wherein the following relations are satisfied:
?Tg=|Tgp?Tgm|?20° C., where Tgp represents a glass transition temperature of the non-polymerizable resin and Tgm represents a glass transition temperature of a homopolymer of the mono-functional monomer,
TgH?20 degrees C., where TgH represents the higher of Tgp and Tgm, and
TgL?0 degrees C., where TgL represents the lower of Tgp and Tgm.

US Pat. No. 10,138,373

FLEXIBLE POLYURETHANE AND POLYURETHANE/POLYORGANOSILOXANE FOAM MATERIALS THAT ABSORB IMPACT ENERGY

Virfex, LLC, West Wareha...

1. A polyurethane and polyorganosiloxane foam article comprising, at least one layer of cross-linked polyurethane/polyorganosiloxane foam including:a) a polyurethane formed by reacting an isocyanate and a polyol;
b) a polyorganosiloxane having at least one of a hydroxyl-reactive functional group and an isocyanate-reactive functional group, wherein the polyorganosiloxane has the formula,

wherein n=1000-5000, R2 and R3 are individually organic groups selected from methyl, ethyl, and phenyl, R1 is a terminal group selected from a trialkylsilyl group, and Ra is a hydroxy or amine group;
c) a polymerization catalyst;
d) a polymerization reaction initiator, said initiator being an isoprenoid compound; and
e) a polymerization reaction accelerator;
wherein the polyurethane and the polyorganosiloxane are cross-linked to one another.

US Pat. No. 10,138,369

POLYMER COMPOSITIONS AND METHODS

Saudi Aramco Technologies...

1. An epoxide CO2 copolymer composition comprising epoxide CO2 copolymer chains wherein:one or more chain ends of at least a portion of the epoxide CO2 copolymer chains within the epoxide CO2 copolymer composition have a formula:

where,
R1, R2, R3, and R4 are, at each occurrence in the polymer chain, independently selected from the group consisting of —H, fluorine, an optionally substituted C1-30 aliphatic group, and an optionally substituted C1-20 heteroaliphatic group, and an optionally substituted C6-10 aryl group, where any two or more of R1, R2, R3, and R4 may optionally be taken together with intervening atoms to form one or more optionally substituted rings optionally containing one or more heteroatoms and/or one or more sites of unsaturation;
—Q— is a bivalent or multivalent moiety;
each Z comprises an adhesion enhancing functional group independently selected from the group consisting of: silicon-containing functional groups, phosphorous-containing functional groups, —SO3H, —CO2H, and —N(R?)3+ where each R? is at each occurrence, independently selected from the group consisting of optionally substituted phenyl, and optionally substituted C1-12 aliphatic; and
? is an integer from 1 to 4 inclusive;
the epoxide CO2 copolymer composition is characterized in that, on average in the composition, the percentage of carbonate linkages in epoxide CO2 copolymer chains is 90% or greater;
the number average molecular weight of the epoxide CO2 copolymer composition is less than about 20,000 g/mol; and
further, wherein one or more chain ends of at least a portion of the epoxide CO2 copolymer chains within the epoxide CO2 copolymer composition have a formula:

where,
R1, R2, R3, and R4 are, at each occurrence in the polymer chain, independently selected from the group consisting of —H, fluorine, an optionally substituted C1-30 aliphatic group, and an optionally substituted C1-20 heteroaliphatic group, and an optionally substituted C6-10 aryl group, where any two or more of R1, R2, R3, and R4 may optionally be taken together with intervening atoms to form one or more optionally substituted rings optionally containing one or more heteroatoms and/or one or more sites of unsaturation.

US Pat. No. 10,138,366

WATER-IN-OIL POLYACRYLAMIDE-BASED MICROEMULSIONS AND RELATED METHODS

Exacto, Inc., Sharon, WI...

1. A water-in-oil microemulsion, comprising:a polyacrylamide;
a fatty acid comprising a tall oil fatty acid, oleic acid, or a combination of a tall oil fatty acid and oleic acid;
a surfactant;
an oil continuous phase comprising a methyl ester of cottonseed oil, canola oil, soybean oil, corn oil, palm kernel oil, coconut oil, or a combination thereof; and
an aqueous discontinuous phase in the oil continuous phase,
wherein the water-in-oil microemulsion contains 6 to 48 parts by weight of the polyacrylamide, 30 to 62 parts by weight of the fatty acid, and 20 to 44 parts by weight of the surfactant per 100 parts by weight of the polyacrylamide, the fatty acid, and the surfactant combined.

US Pat. No. 10,138,356

LIQUID COMPOSITION COMPRISING POLYMER CHAINS AND PARTICLES OF AN INORGANIC MATERIAL IN A LIQUID

NEDERLANDSE ORGANISATIE V...

1. A liquid composition comprising polymer chains and particles of an inorganic material in a liquid, the polymer chains comprising a functional group, whereinthe polymer chains are linked to particles of the inorganic material by means of the functional group that is present in the polymer chains;
the functional group is selected from the group consisting of amine, epoxide, acid, anhydride, ammonium, carboxylate, sulfate, sulfonate, sulfinate, silane, phosphate, phosphonate, phosphinate, phosphite, phosphinite, sulfide, disulfide, maleic acid, phosphine, phosphine oxide, phosphonium, sulphonium, oxonium, and aldehyde;
the polymer chains have a number average molecular weight in the range of 500 to 100,000 Dalton;
the polymer used has a lower critical solution temperature in the range of ?20° C. to 100° C. in the liquid used;
the liquid composition exhibits thermo-induced gelation; and
the inorganic material is selected from the group consisting of minerals, silicates, metal oxides, clays, synthetic clays, and layered double hydroxides.

US Pat. No. 10,138,352

FLUOROELASTOMER COMPOSITION AND MOLDED ARTICLE

DAIKIN INDUSTRIES, LTD., ...

1. A fluoroelastomer composition comprising:a fluoroelastomer; and
at least one compound (a) selected from the group consisting of:
a compound (1) represented by the following formula (1):
wherein an aromatic ring may be substituted; anda compound (2) represented by the following formula (2):
wherein an aromatic ring may be substituted.

US Pat. No. 10,138,325

POLYPHENOLIC CONDENSATES AND EPOXY RESINS THEREOF

CHANG CHUN PLASTICS CO., ...

1. Polyphenolic condensates from aldehydes and phenolic compounds which comprise: an aldehyde-phenolic condensate having a range of weight average molecular weight (Mw), calculated as polystyrene and phenol, satisfying the expression, 1.3×[1×(Molecular weight of aldehydes)+2×(Molecular weight of phenolic compounds)?2×(Molecular weight of water)] to 1.5×[3×(Molecular weight of aldehydes)+3×(Molecular weight of phenolic compounds)?2×(Molecular weight of water)]; the Mw range takes about 35% to about 50% of overall Gel-Permeation Chromatography (GPC) integrated area at a detection wavelength of 254 nm; and a Gardner Index is not more than 13.

US Pat. No. 10,138,323

HIGHLY BRANCHED POLYMER AND DISPERSANT FOR CARBON NANOTUBES

NISSAN CHEMICAL INDUSTRIE...

1. A highly branched polymer characterized by comprising repeating units of formula (1) or formula (2) belowwhereinAr1 to Ar3 are each independently a divalent organic group of any one of formulas (3) to (7) below
in which R5 to R38 are each independently a hydrogen atom, a halogen atom, an alkyl group of 1 to 5 carbons which may have a branched structure, an alkoxy group of 1 to 5 carbons which may have a branched structure, or a carboxyl group, sulfo group, phosphoric acid group, phosphonic acid group or salt of any thereof;Z1 and Z2 are each independently a hydrogen atom, an alkyl group of 1 to 5 carbons which may have a branched structure, or a monovalent organic group of any one of formulas (8) to (11) below
in which R39 to R62 are each independently a hydrogen atom, a halogen atom, an alkyl group of 1 to 5 carbons which may have a branched structure, a haloalkyl group of 1 to 5 carbons which may have a branched structure, a phenyl group, OR63, COR63, NR63R64, COOR65 (R63 and R64 being each independently a hydrogen atom, an alkyl group of 1 to 5 carbons which may have a branched structure, a haloalkyl group of 1 to 5 carbons which may have a branched structure, or a phenyl group; and R65 being an alkyl group of 1 to 5 carbons which may have a branched structure, a haloalkyl group of 1 to 5 carbons which may have a branched structure, or a phenyl group), or a carboxyl group, sulfo group, phosphoric acid group, phosphonic acid group or salt of any thereof, with the proviso that Z1 and Z2 are not both alkyl groups; and R1 to R4 in formula (2) are each independently a hydrogen atom, a halogen atom, an alkyl group of 1 to 5 carbons which may have a branched structure, an alkoxy group of 1 to 5 carbons which may have a branched structure, or a carboxyl group, sulfo group, phosphoric acid group, phosphonic acid group or salt of any thereof;with the proviso that at least one type of acidic group selected from among carboxyl groups, sulfo groups, phosphoric acid groups, phosphonic acid groups, and salts thereof is present on at least one aromatic ring of the repeating unit of formula (1) or (2).

US Pat. No. 10,138,305

ATMOSPHERIC PRESSURE PLASMA PROCESSING OF POLYMERIC MATERIALS UTILIZING CLOSE PROXIMITY INDIRECT EXPOSURE

UT-Battelle, LLC, Oak Ri...

1. A plasma treatment apparatus comprising:a treatment chamber comprising: (i) an interior treatment volume having an entrance and exit for processing a workpiece and an asymmetrical electrode assembly for generating a plasma, and (ii) an intermediate heating volume for heating the interior treatment volume;
at least one process gas inlet into the interior treatment volume;
wherein the asymmetrical electrode assembly comprises at least two plasma-generating electrodes that are separated from each other and present on a surface of a dielectric barrier, and wherein the at least two plasma-generating electrodes differ in at least one of a width and a length dimension to provide an asymmetrical geometry of the plasma-generating electrodes.

US Pat. No. 10,138,274

CRYSTAL OF CYCLIC PEPTIDE COMPOUND, PREPARATION METHOD FOR SAME AND USES THEREOF

SHANGHAI TECHWELL BIOPHAR...

1. Crystal A of a cyclic peptide compound of formula I:
wherein said crystal A has characteristic peaks at the following 2? angles in the X-ray power diffraction pattern (XRPD): 3.6±0.2°, 6.4±0.2°, 6.8±0.2°, and 9.5±0.2°.

US Pat. No. 10,138,270

SYNTHETIC PEPTIDE AMIDES

Cara Therapeutics, Inc., ...

1. A method of treating a kappa opioid receptor-associated disease or condition in a mammal, wherein the kappa opioid receptor-associated disease or condition is a kappa opioid receptor-associated chronic kidney disease, the method comprising administering to the mammal a composition comprising an effective amount of a synthetic peptide amide having the formula:
or a stereoisomer, mixture of stereoisomers, pharmaceutically acceptable salt, hydrate, acid salt hydrate or N-oxide thereof;whereinXaa1 is selected from the group consisting of (A)(A?)D-Phe, (A)(A?)(?-Me)D-Phe, D-Tyr, D-Tic, D-tert-leucine, D-neopentylglycine, D-phenylglycine, D-homophenylalanine, and ?-(E)D-Ala, wherein each (A) and each (A?) are phenyl ring substituents independently selected from the group consisting of —H, —F, —Cl, —NO2, —CH3, —CF3, —CN, and —CONH2, and wherein each (E) is independently selected from the group consisting of cyclobutyl, cyclopentyl, cyclohexyl, pyridyl, thienyl and thiazolyl;
Xaa2 is selected from the group consisting of (A)(A?)D-Phe, 3,4-dichloro-D-Phe, (A)(A?)(?-Me) D-Phe, D-1Nal, D-2Nal, D-Tyr, (E)D-Ala and D-Trp;
Xaa3 is selected from the group consisting of D-Nle, D-Phe, (E)D-Ala, D-Leu, (?-Me)D-Leu, D-Hle, D-Val, and D-Met;
Xaa4 is selected from the group consisting of (B)2D-Arg, (B)2D-Nar, (B)2D-Har, ?-(B)D-Hlys, D-Dap, ?-(B)D-Lys, ?-(B)2-D-Lys, D-Amf, amidino-D-Amf, ?-(B)2D-Dbu, ?-(B)2?-(B?)D-Orn, D-2-amino-3(4-piperidyl) propionic acid, D-2-amino-3(2-amino-pyrrolidyl)propionic acid, D-?-amino-?-amidinopropionic acid, ?-amino-4-piperidineacetic acid, cis-?,4-diaminocyclohexane acetic acid, trans-?,4-diamino-cyclohexane acetic acid, cis-?-amino-4-methylaminocyclo-hexane acetic acid, trans-?-amino-4-methylaminocyclohexane acetic acid, ?-amino-1-amidino-4-piperidineacetic acid, cis-?-amino-4-guanidinocyclohexane acetic acid, and trans-?-amino-4-guanidino cyclohexane acetic acid, wherein each (B) is independently selected from the group consisting of H and C1-C4 alkyl, and (B?) is H or (?-Me);
W is selected from the group consisting of:
Null, provided that when W is null, Y is N;
—NH—(CH2)b— with b equal to zero, 1, 2, 3, 4, 5, or 6; and
—NH—(CH2)c—O— with c equal to 2, or 3, provided that Y is C;
the moiety

is an optionally substituted 4 to 8-membered heterocyclic ring moiety wherein all ring heteroatoms in said ring moiety are N; wherein Y and Z are each independently C or N; provided that when such ring moiety is a six, seven or eight-membered ring, Y and Z are separated by at least two ring atoms; and provided that when such ring moiety has a single ring heteroatom which is N, then such ring moiety is non-aromatic;
V is C1-C6 alkyl, and e is zero or 1, wherein when e is zero, then V is null and R1 and R2 are directly bonded to the same or different ring atoms;
wherein (i) R1 is selected from the group consisting of —H, —OH, halo, —CF3, —NH2, —COOH, C1-C6 alkyl, C1-C6 alkoxy, amidino, C1-C6 alkyl-substituted amidino, aryl, optionally substituted heterocyclyl, Pro-amide, Pro, Gly, Ala, Val, Leu, Ile, Lys, Arg, Orn, Ser, Thr, —CN, —CONH2, —COR?, —SO2R?, —CONR?R?, —NHCOR?, OR? and SO2NR?R?; wherein said optionally substituted heterocyclyl is optionally singly or doubly substituted with substituents independently selected from the group consisting of C1-C6 alkyl, C1-C6 alkoxy, oxo, —OH, —Cl, —F, —NH2, —NO2, —CN, —COOH, and amidino; wherein R? and R? are each independently —H, C1-C8 alkyl, aryl, or heterocyclyl or R? and R? are combined to form a 4- to 8-membered ring, which ring is optionally singly or doubly substituted with substituents independently selected from the group consisting of C1-C6 alkyl, -C1-C6 alkoxy, —OH, —Cl, —F, —NH2, —NO2, —CN, —COOH and amidino; and R2 is selected from the group consisting of —H, amidino, singly or doubly C1-C6 alkyl-substituted amidino, —CN, —CONH2, —CONR?R?, —NHCOR', —SO2NR?R? and —COOH; or
(ii) R1 and R2 taken together can form an optionally substituted 4- to 9-membered heterocyclic monocyclic or bicyclic ring moiety which is bonded to a single ring atom of the Y and Z-containing ring moiety; or
(iii) R1 and R2 taken together with a single ring atom of the Y and Z-containing ring moiety can form an optionally substituted 4- to 8-membered heterocyclic ring moiety to form a spiro structure; or
(iv) R1 and R2 taken together with two or more adjacent ring atoms of the Y and Z-containing ring moiety can form an optionally substituted 4- to 9-membered heterocyclic monocyclic or bicyclic ring moiety fused to the Y and Z-containing ring moiety;
wherein each of said optionally substituted 4-, 5-, 6,-, 7-, 8- and 9-membered heterocyclic ring moieties comprising R1 and R2 is optionally singly or doubly substituted with substituents independently selected from the group consisting of C1-C6 alkyl, C1—C6 alkoxy, optionally substituted phenyl, oxo, —OH, —Cl, —F, —NH2, —NO2, —CN, —COOH, and amidino;
provided that when the Y and Z-containing ring moiety is a six or seven membered ring having a single ring heteroatom and e is zero, then R1 is not —OH, and R1 and R2 are not both —H;
provided further that when the Y and Z-containing ring moiety is a six membered ring having two ring heteroatoms, both Y and Z are N and W is null, then —(V)eR1R2 is attached to a ring atom other than Z; and if e is zero, then R1 and R2 are not both —H; and
lastly, provided that when Xaa3 is D-Nle, then Xaa4 is not (B)2D-Arg, and when Xaa3 is D-Leu or (?Me)D-Leu, then Xaa4 is not ?—(B)2?—(B?)D-Orn.

US Pat. No. 10,138,267

BIOCONJUGATES OF HETEROCYCLIC COMPOUNDS

HUNAN SKYWORLD BIOTECHNOL...

1. A compound having the formula I
wherein A, B, C and D are N; and n=3-100.

US Pat. No. 10,138,260

COMPOUNDS OF PHOSPHINANES AND AZAPHOSPHINANES, A PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM

LES LABORATOIRES SERVIER,...

1. A compound of formula (I):
wherein:
Ak1 represents a C1-C6-alkyl chain;
X represents —(CH2)m—, —CH(R)—, —N(R)—, —CH2—N(R)—, —N(R)—CH2— or —CH2—N(R)—CH2—;
m represents 0 or an integer from 1 to 4;
R represents a hydrogen atom, C1-C6-alkyl, -Ak2-Ar1, -Ak2-Ar1-Ar2, -Ak2-Ar1-O—Ar2, -Ak2-cycloalkyl or -Ak2-OH;
Ak2 represents a linear or branched C1-C6-alkyl chain;
Ar1 and Ar2, which may be identical or different, each represent an aryl or heteroaryl group;
R1 and R2 each represent a hydrogen atom when X represents —(CH2)m—, —CH(R)—, —N(R)—, —CH2—N(R)— or —N(R)—CH2—,
or together form a bond when X represents —CH2—N(R)—CH2—;
R3 represents NH2, Cy-NH2, Cy-Ak3-NH2 or piperidin-4-yl;
Cy represents cycloalkyl, aryl or heteroaryl;
Ak3 represents a C1-C3-alkyl chain;
R4 and R5, which may be identical or different, each represent a hydrogen atom or a fluorine atom;
its optical isomers, and addition salts thereof with a pharmaceutically acceptable acid.

US Pat. No. 10,138,259

PROCESS FOR THE PREPARATION OF ACYLPHOSPHANES

ETH ZUERICH, Zurich (CH)...

1. A process for the preparation of compounds of formula (I):
wherein,
n is 1,
m is 1 or 2,
R1 is a substituent of formula (IIa)
—C(1)R62—C(2)H(Z)(R7)  (IIa)
wherein,
(1) and (2) indicate the numeration of the carbon atom, wherein C(1) is bound to the central phosphorous atom depicted in formula (I), and
Z is a substituent selected from the group consisting of —CN, —NO2, —(CO)H, —(CO)R8, —(CO)OH, —(CO)OR8, —(CO)NH2, —(CO)NH(R8), —(CO)N(R8)2, —(SO2)R8, —(PO)(R8)2, —(PO)(OR8)2, —(PO)(OR8)(R8) or heteroaryl
R6 and R7 each substituent independently is hydrogen, Z or R8 and
R8 independently of further substituents R8 which may be present in the substituent of formula (IIa) is alkyl, alkenyl or aryl or two substituents R8 irrespective of whether they are both part of a substituent Z or belong to different substituents selected from Z, R6 and R7 together are alkanediyl or alkenediyl or alternatively, where two substituents —(CO)R8 are present within the substituent of formulae (IIa) are together —O— or —NR4—,
wherein, the alkyl, alkenyl, aryl, alkanediyl and alkenediyl substituents are
either not, once, twice or more than twice interrupted by non-successive functional groups selected from the group consisting of:
—O—, —S—, —SO2—, —SO—, —SO2NR4—, NR4SO2—, —NR4—, —CO—, —O(CO)—, (CO)O—, —O(CO)O—, —NR4(CO)NR4—, NR4(CO)—, —(CO)NR4—, —NR4(CO)O—, —O(CO)NR4—, —Si(R5)2—, —OSi(R5)2—, —OSi(R5)2O—, —Si(R5)2O—,
and,
either not, additionally or alternatively either once, twice or more than twice interrupted by bivalent residues selected from the group consisting of heterocyclo-diyl, and aryldiyl,
and,
either not, additionally or alternatively either once, twice or more than twice substituted by substituents selected from the group consisting of:
oxo, hydroxy, halogen, cyano, azido, C6-C14-aryl, C1-C8-alkoxy, C1-C8-alkylthio, —SO3M, —COOM, PO3M2, —PO(N(R5)2)2, PO(OR5)2, —SO2N(R4)2, —N(R4)2, —N(R4)3+An?, —CO2N(R5)2, —COR4, —OCOR4, —NR4(CO)R5, —(CO)OR4, —NR4(CO)N(R4)2, —Si(OR)y(R5)3-y, —OSi(OR)y(R5)3-y with y=1, 2 or 3, or
or R1 is a substituent of formulae (IIb), (IIc) or (IId)
—C(1)R62—N(R8)2  (IIb)
—C(1)R62—NH(R8)  (IIc)
—(C(1)?O)—NHR8  (IId),
wherein,
(1) indicates the carbon atom bound to the central phosphorous atom depicted in formula (I), and
R2 and R3 are independently of each other aryl or heterocyclyl, alkyl or alkenyl,
wherein, the aforementioned alkyl and alkenyl substituents of R2 and R3 are
either not, once, twice or more than twice interrupted by non-successive functional groups selected from the group consisting of:
—O—, —NR4—, —CO—, —OCO—, —O(CO)O—, NR4(CO)—, —NR4(CO)O—, O(CO)NR4—, —NR4(CO)NR4—,
and,
either not, additionally or alternatively either once, twice or more than twice interrupted by bivalent residues selected from the group consisting of heterocyclo-diyl, and aryldiyl,
and
either not, additionally or alternatively either once, twice or more than twice substituted by substituents selected from the group consisting of:
oxo, hydroxyl, halogen, cyano, C6-C14-aryl; heterocyclyl, C1-C8-alkoxy, C1-C8-alkylthio, —COOM, —SO3M, —PO3M2, —SO2N(R4)2, —NR4SO2R5, —N(R4)2—, —N+(R4)3An?, —CO2N(R4)2, —COR4—, —OCOR5, —O(CO)OR5, NR4(CO)R4, —NR4(CO)OR4, O(CO)N(R4)2, —NR4(CO)N(R4)2,
wherein, in all formulae where used
R4 is independently selected from the group consisting of hydrogen, C1-C8-alkyl, C6-C14-aryl, and heterocyclyl or N(R4)2 as a whole is a N-containing heterocycle,
R5 is independently selected from the group consisting of C1-C8-alkyl, C6-C14-aryl, and heterocyclyl or N(R5)2 as a whole is a N-containing heterocycle,
M is hydrogen, or 1/q equivalent of an q-valent metal ion or is an ammonium ion or a guanidinium ion or a primary, secondary, tertiary or quarternary organic ammonium ion, and
An? is 1/p equivalent of a p-valent anion,
the process comprising at least the step of reacting compounds of formula (III):

with compounds of formulae (IVa), (IVb), (IVc) or (IVd),
R62C(1)=C(2)(Z)(R7)  (IVa),
R62C(1)?N+(R8)2An?  (IVb),
R62C(1)?NR8  (IVc),
R8—NCO  (IVd),
wherein, in formulae (III) and (IVa) to (IVf),
(1), (2), R2, R3, R6, R7, R8, n, m, An and Z have the same meaning as described for formulae (I) and (IIa) to (IId) above, and
wherein, in formula (II),
M2 is hydrogen, or 1/q equivalent of an q-valent metal ion or is an ammonium ion or a heterocycylium cation, a guanidinium ion or a primary, secondary, tertiary or quarternary organic ammonium ion, and
wherein the reaction if M2 is hydrogen is carried out in the presence of a base.

US Pat. No. 10,138,255

PIPERAZINE DERIVATIVES AS HIV PROTEASE INHIBITORS

1. A compound of structural Formula I:
or a pharmaceutically acceptable salt thereof, wherein:
X is O or CH2;
Ring A is

wherein * indicates the point of attachment to X* in Formula I and ** indicates the point of attachment to N** in Formula I;
one, two or three of Y1, y2, y3 and Y4 are N and the others are C(R);
HetAr is:
(a) a 5-membered (including the two carbons that are the points of attachment to X* and N** in Formula I) monocyclic heteroaromatic ring containing from 1 to 3 heteroatoms independently selected from N, O and S, or
(b) a 9-, 10- or 11-membered (including the two carbons that are the points of attachment to X* and N** in Formula I) bicyclic heteroaromatic ring system containing from 1 to 4 heteroatoms independently selected from N, O and S;
p is an integer selected from 1, 2 or 3;
R is independently selected at each occurrence from,
(a) —H,
(b) halo, —OH, —SH, —CN, —NO2, or —N(R3a)2,
(c) —C1-6alkyl unsubstituted or substituted with (i) 1 to 6 of —F, or (ii) —OH, —C(O)OC1-6alkyl, —O—C1-6alkyl or —O—C1-3 alkyl-phenyl,
(d) —OC1-6alkyl unsubstituted or substituted with (i) 1 to 6 of —F, or (ii) —OH, —C(O)OC1-6alkyl, —O—C1-6alkyl or —O—C1-3 alkyl-phenyl,
(e) —C1-6alkyl-O—C1-3alkyl unsubstituted or substituted with 1 to 6 of —F,
(f) —C(O)OC1-6alkyl unsubstituted or substituted with 1-6 of —F, or
(g) —C(O)C1-6alkyl unsubstituted or substituted with 1-6 of —F;
Z1 is

Ra and Rb are independently selected from —H and —C1-3alkyl;
Rc is —C1-3alkyl or —C3-6cycloalkyl and Rc is unsubstituted or substituted with 1-3 of —F;
Rd is —C1-6alkyl unsubstituted or substituted with 1-6 of —F or —C3-6cycloalkyl unsubstituted or substituted with 1-3 of —F;
m is the integer 1;
Z2 is —H or —NHR3;
R2a is
(a) —C1-6alkyl unsubstituted or substituted with one to four substituents independently selected at each occurrence from halo; —OH; —C1-6alkyl unsubstituted or substituted with 1-3 of —F; or —ORc;
(b) —C3-6cycloalkyl unsubstituted or substituted with one to four substituents independently selected at each occurrence from halo; —OH; —C1-6alkyl unsubstituted or substituted with 1-6 of —F; —C1-3alkyl —ORc; —ORd; —COOH; or —C(O)ORd;
(c) phenyl unsubstituted or substituted with one to four substituents independently selected at each occurrence from halo; —OH; —C1-6alkyl unsubstituted or substituted with 1-6 of —F; —C1-3alkyl-O—Rc; —ORd; —COOH; —C(O)ORd; or —C3-6cycloalkyl unsubstituted or substituted with 1-3 of —F;
wherein the tetrahydropyran is unsubstituted or substituted with one to four substituents independently selected at each occurrence from halo —OH; —C1-6alkyl unsubstituted or substituted with 1-6 of —F; or —OC1-6alkyl unsubstituted or substituted with 1-6 of —F;(e) pyridinyl unsubstituted or substituted with one to four substituents independently selected at each occurrence from
(i) halo, (ii) —OH,
(iii) —C1-6alkyl unsubstituted or substituted with (i) 1 to 6 of —F, or (ii) —OH, —C(O)OC1-6alkyl, —O—C1-6alkyl, or —O—C1-3 alkyl-phenyl,
(iv) —OC1-6alkyl unsubstituted or substituted with (i) 1 to 6 of —F, or (ii) —OH, —C(O)OC1-6alkyl, —O—C1-6alkyl, or —O—C1-3 alkyl-phenyl,
(v) —C1-6alkyl-O—C1-3alkyl unsubstituted or substituted with 1 to 6 of —F,
(vi) ?O (oxo),
(vii) —C(O)OC1-6alkyl optionally substituted with 1-6 of —F, or
(viii) —C(O)C1-6alkyl optionally substituted with 1-6 of —F;
(f) pyrimidinyl, unsubstituted or substituted with one to four substituents independently selected at each occurrence from
(i) halo, (ii) —OH,
(iii) —C1-6alkyl unsubstituted or substituted with (i) 1 to 6 of —F, or (ii) —OH, —C(O)OC1-6alkyl, —O—C1-6alkyl, or —O—C1-3 alkyl-phenyl,
(iv) —OC1-6alkyl unsubstituted or substituted with (i) 1 to 6 of —F, or (ii) —OH, —C(O)OC1-6alkyl, —O—C1-6alkyl, or —O—C1-3 alkyl-phenyl,
(v) —C1-6alkyl-O—C1-3alkyl unsubstituted or substituted with 1 to 6 of —F,
(vi) ?O (oxo),
(vii) —C(O)OC1-6alkyl optionally substituted with 1-6 of —F, or
(viii) —C(O)C1-6alkyl optionally substituted with 1-6 of —F;
unsubstituted or substituted with one to four substituents independently selected at each occurrence from halo; —OH; —C1-6alkyl unsubstituted or substituted with 1-6 of —F; —OC1-6alkyl unsubstituted or substituted with 1-6 of —F; or —C3-6cycloalkyl unsubstituted or substituted with 1-3 of —F;
(i) morpholinyl;
(j) piperidinyl, unsubstituted or substituted with one to four substituents independently selected at each occurrence from halo; —OH; —C1-6alkyl unsubstituted or substituted with 1-6 of —F;
—OC1-6alkyl unsubstituted or substituted with 1-6 of —F; or —C(O)OR1;
(k) pyrazinyl, unsubstituted or substituted with one to four substituents independently selected at each occurrence from halo; —OH; —C1-6alkyl unsubstituted or substituted with 1-6 of —F; —OC1-6alkyl unsubstituted or substituted with 1-6 of —F; or —C(O)OR1;
(l) thiazolyl, unsubstituted or substituted with one to three substituents independently selected at each occurrence from halo; —OH; —C1-6alkyl unsubstituted or substituted with 1-6 of —F; —OC1-6alkyl unsubstituted or substituted with 1-6 of —F; or —C(O)OR1;
(m) pyrazolyl, unsubstituted or substituted halo; —OH; —C1-6alkyl unsubstituted or substituted with 1-6 of —F; —OC1-6alkyl unsubstituted or substituted with 1-6 of —F; or —C(O)OR1; or

R1 is (i) —C1-6alkyl unsubstituted or substituted with 1-6 of —F, phenyl or —C3-6cycloalkyl, or (ii) —S(O)2—C1-6alkyl;
R2b is —H, —C1-6alkyl or —OC1-6alkyl, wherein each of —C1-6alkyl or —OC1-6alkyl is unsubstituted or substituted with 1 to 3 substituents independently selected from halo, —OH, or —OC1-6alkyl;
or R2a and R2b are joined together with the carbon to which they are both attached to form (a) —C3-6cycloalkyl, (b) piperidinyl, or (c) tetrahydro-(2H)-furanyl;
wherein each of cycloalkyl, piperidinyl and tetrahydro-(2H)-furan is unsubstituted or substituted with one to four substituents independently selected at each occurrence from halo;
—OH; —C1-6alkyl unsubstituted or substituted with 1-6 of —F; —OC1-6alkyl unsubstituted or substituted with 1-6 of —F; or —COOC1-3 alkyl unsubstituted or substituted with 1-6 of —F;
R3 and R3a are independently selected at each occurrence from
(a) —H,
(b) —C1-6alkyl unsubstituted or substituted with (i) 1 to 6 of —F, (ii) —OH, (iii) —C(O)OC1-3alkyl, (iv) —O—C1-3 alkyl, or (v) —O—C1-3 alkyl-phenyl,
(c) —C(O)OC1-6alkyl unsubstituted or substituted with (i) 1-6 of —F, (ii) —C3-6cycloalkyl or (iii) —NH2, or
(d) —C(O)C1-6alkyl unsubstituted or substituted with (i) 1-6 of —F, (ii) —C3-6cycloalkyl or (iii) —NH2;
n is an integer selected from 1, 2 or 3;
R4 is independently selected at each occurrence from:
(a) —H, —OH, halo, —CN, —C1-6alkyl, —O—C1-6alkyl, —C3-6cycloalkyl, —O—C3-6cycloalkyl, —C2-6alkenyl-SR5, —S—C3-6cycloalkyl, —SO2R5, —N(R5)2, —N(H)C(O)—C1-6alkyl, —C(O)OR5, —C(O)—C1-6alkyl, —C1-6haloalkyl, —O—C1-6haloalkyl, —S—C1-6haloalkyl, —NO2, —N(H)CH(O), —CH(O), —C(O)N(R5)2, —C(O)N(H)C(O)R5, or trimethylsilyl,
(b) phenyl, benzyl or phenoxy, each being unsubstituted or substituted with 1 to 5 substituents selected from halogen and, —OH, halo, —CN, —C1-6alkyl, —C1-6haloalkyl, —O—C1-6alkyl, —O—C1-6haloalkyl, —S—C1-6haloalkyl, —NO2, —SO2R5, —N(R5)2, —C(O)OR5, or —C(O)—C1-6alkyl, or
(c) HetA, —O-HetA or —CH2—HetA, optionally substituted with 1 to 5 substituents selected from halogen and C1-6alkyl;
wherein —C1-6 alkyl when present within any R4 group is unsubstituted or substituted with 1 to 6 substituents independently selected at each occurrence from:
-halo, —CF3, —CN, —NO2, —OH, —O—C1-6alkyl, —O—C1-6haloalkyl, —O—C3-6cycloalkyl, —SR5, —N(R5)2, —C(O)—C1-6alkyl, —C(O)OR5, or —SO2—C1-6alkyl;
R5 is independently selected at each occurrence from —H and C1-6alkyl; and
HetA is independently selected from (i) a 5- or 6-membered monocyclic heteroaromatic ring containing from 1 to 3 heteroatoms independently selected from N, O and S, or (ii) a 9-, 10- or 11-membered bicyclic fused heteroaromatic ring system containing from 1 to 4 heteroatoms independently selected from N, O and S.

US Pat. No. 10,138,254

BICYCLIC COMPOUNDS AS PEST CONTROL AGENTS

BAYER CROPSCIENCE AKTIENG...

1. A compound of formula (I),
wherein
A is the (A-a) radical

wherein the broken line denotes the bond to the carbon atom of the bicyclic system of the formula (I),
G1 is C-B1,
B1 is hydrogen or fluorine,
B2 is hydrogen,
T is oxygen or an electron pair,
Q is sulphur,
R1 is hydrogen,
R2 is a B radical selected from the group consisting of

wherein the broken line denotes the bond to the carbon atom of the bicyclic system of the formula (I), or
R2 is a radical of formula

wherein the broken line denotes the bond to the carbon atom of the bicyclic system of the formula (I), or
R2 is a radical of formula

wherein the broken line denotes the bond to the carbon atom of the bicyclic system of the formula (I), in which
G2 is a radical selected from the group consisting of hydrogen, C1-C4-alkyl, halo-C1-C4-alkyl, C1-C4-alkoxy, halo-C1-C4-alkoxy, C1-C4-alkylthio and C1-C4-haloalkylthio,
and in the case that R2 is the radical of formula

R22 is the D radical

wherein
R is optionally mono-, di-, tri-, tetra- or penta-fluorine- or -chlorine-substituted C1-C4-alkyl,
W is a radical from the group of S, SO and SO2,
R23 is hydrogen or C1-C6-alkyl,and in the case that R2 is the radical of formula
R22 is phenyl which is optionally fluorine-, chlorine- or bromine-substituted, and
R23 is hydrogen or C1-C6-alkyl.

US Pat. No. 10,138,253

IMIDAZOPYRIDINE MACROCYCLES AS INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION

ViiV HEALTHCARE UK (NO.5)...

1. A compound of Formula I
wherein:
R1 is alkyl;
R2 is alkyl;
R3 is selected from hydrogen, cyano, halo, alkyl, hydroxyalkyl, alkoxyalkyl, (Ar1)alkyl, or alkenyl;
R4 is selected from hydrogen, halo, or alkyl;
R5 is piperidinyl substituted with 0-3 substituents selected from halo, alkyl, haloalkyl, hydroxy, alkoxy, and haloalkoxy;
Ar1 is selected from pyrazolyl or triazolyl;
X1 is phenyl substituted with 0-3 substituents selected from cyano, halo, alkyl, haloalkyl, alkoxy, and haloalkoxy;
X2 is phenyl substituted with 0-3 substituents selected from cyano, halo, alkyl, haloalkyl, alkoxy, and haloalkoxy;
X3 is —O—;
X4 is alkyleneoxyalkylene; and
X5 is —O—;
or a pharmaceutically acceptable salt thereof.

US Pat. No. 10,138,252

LACTONES

PURDUE RESEARCH FOUNDATIO...

1. A compound of formula II:
or any salt thereof, wherein
R1 is H, C1-C8 straight or branched alkyl, C3-C8 cycloalkyl, C6-C10 aryl, C4-C10 heteroaryl, hydroxyl, C1-C6 straight or branched alkoxyl, —C(X)—R10, —C(X)—OR11, —SO2R12, —C(X)NR13R14, or a nitrogen-protecting group, wherein the alkyl, aryl or heteroaryl is optionally substituted with one or more —NO2, halogen, CF3, or phenyl;
R2, R3, R, R5, R6, and R7 are independently H, C1-C8 straight or branched alkyl, C3-C8 cycloalkyl, C6-C10 aryl, C4-C10 heteroaryl, hydroxyl, halogen, or C1-C6 straight or branched alkoxyl, wherein the alkyl, aryl or heteroaryl is optionally substituted with one or more —NO2, halogen, CF3, or phenyl;
R8, R9 are independently H, C1-C8 straight or branched alkyl, C3-C8 cycloalkyl, C6-C10 aryl, C4-C10 heteroaryl, C1-C6 straight or branched alkoxyl, wherein R8, R9 may form a C3-C10 mono or bicyclic carbon ring or heterocyclic ring comprising N, O, or S, and when the heterocyclic formed by R8 and R9 has N, the N is optionally attached to C1-C8 straight or branched alkyl, C3-C8 cycloalkyl, C6-C10 aryl, C4-C10 heteroaryl, or a nitrogen-protecting group;
R10-R14 are independently H, C1-C8 straight or branched alkyl, C3-C8 cycloalkyl, C6-C10 aryl, C4-C10 heteroaryl, wherein the alkyl, aryl or heteroaryl is optionally substituted with one or more C1-C4 straight or branched alkyl, —NO2, halogen, or CF3, and
X is O or S.

US Pat. No. 10,138,250

SALT OF PYRROLO[2,3-D]PYRIMIDINE COMPOUND AND NOVEL POLYMORPH OF SALT

Crystal Pharmatech Co., L...

1. A crystalline mono-succinate Form I of compound I,
wherein the X-ray powder diffraction pattern of the crystalline Form I shows characteristic peaks at 2theta values of 20.6°±0.2°, 11.9°±0.2°, and 22.7°±0.2°.

US Pat. No. 10,138,248

SUBSTITUTED IMIDAZO[2,1-F][1,2,4]TRIAZINES, SUBSTITUTED IMIDAZO[1,2-A]PYRIDINES, SUBSTITUTED IMIDAZO[1,2-B]PYRIDAZINES AND SUBSTITUTED IMIDAZO[1,2-A]PYRAZINES AS PI3K-? INHIBITORS

Incyte Corporation, Wilm...

20. A pharmaceutical composition comprising a compound of claim 1, or a pharmaceutically acceptable salt or a tautomer thereof, and a pharmaceutically acceptable excipient or carrier.

US Pat. No. 10,138,247

7-(MORPHOLIN-4-YL)PYRAZOLE[1,5-A]PYRIMIDINE DERIVATIVES AS PI3 KINASE INHIBITORS

1. A compound of the general formula (I)
wherein:
Y represents —CH2- or >C?O;
R1 is selected from the group consisting of A1, A2 and A3:

R2 represents:
dioxothiomorpholino moiety B1;

piperazinyl moiety B2

wherein two carbon atoms of the piperazine ring can be optionally joined with methylene bridge —CH2— to form 2,5-diazabicyclic moiety, and R5 is selected from the group consisting of —SO2CH3; —C(O)—C1-C3-alkyl, —C(O)—C3-C5-cycloalkyl; phenyl substituted with —O—C1-C3 alkyl; and —CR6R7R8,
wherein R6, R7 and R8 independently represent hydrogen atom, CH3, cyclopropyl or CONH2, with the proviso that only one of R6, R7 and R8 can represent cyclopropyl or CONH2,
or one of R6, R7 and R8 represents hydrogen atom and remaining two of R6, R7 and R8 are joined together to form —(CH2)2, —(CH2)3, —(CH2)4, or —(CH2—O—CH2)— group;
azetidinyl moiety B3

wherein R9 is selected from the group consisting of morpholino, 2,6-dimethylomorpholino, 1,1-dioxothiomorpholino, 4,4-difluoropiperidynyl and 3-methoxyazetidin-1-yl; or
piperidinyl moiety B4

wherein R10 is selected from the group consisting of C1-C4 alkyl; C1-C4 alkyl substituted with OH; —COO(C1-C3 alkyl); —N(C1-C3 alkyl)2; —NHCONH—C1-C3-alkyl; —NHCONH—C1-C3-phenyl; piperazinyl; and piperazinyl substituted at the position 4 with C1-C3 alkyl;
R3 is selected from the group consisting of H, halogen, and C1-C4 alkyl;
R4 is selected from the group consisting of C1-C4 alkyl, C3-C4-cycloalkyl, C1-C4 alkyl substituted with C1-C4 alkoxy, and CHF2;
X1 and X2 have the following meanings:
(i) X1 represents CH and X2 represents CH or N;
(ii) X1 represents N and X2 represents CH, or
(iii) X1 represents CH and X2 represents C—O—CH3;
X3, X4, X5 and X6 have the following meanings:
(i) X3 represents N, X4 represents CH, X5 represents CH, and X6 represents CH;
(ii) X3 represents CH, X4 represents N, X5 represents CH, and X6 represents CH;
(iii) X3 represents CH, X4 represents CH, X5 represents N, and X6 represents CH;
(iv) X3 represents CH, X4 represents CH, X5 represents CH, and X6 represents CH or CF; or
(v) X3 represents CH, X4 represents CH, X5 represents CF, and X6 represents CH;
X7 represents CH or N;
wavy line indicates the point of attachment;
or pharmaceutically acceptable salts thereof.

US Pat. No. 10,138,245

FUSED TRIAZOLE DERIVATIVES AS PHOSPHODIESTERASE 10A INHIBITORS

1. A compound of the general formula (I)
wherein:
one of X1 and X2 represents N, and the other one of X1 and X2 represents —C(CH3);
A represents an unsubstituted or substituted 5-, 6- or 10-membered aryl or heteroaryl, and when substituted the substituent is selected from the group consisting of halogen, C1-C4-alkyl, CN, and —O—C1-C4-alkyl;
B is selected from the group consisting of B1 and B2 moieties:

R represents H or C1-C3 alkyl;
one of Z1, Z2 and Z3 represents —CR1—, and the others of Z1, Z2 and Z3 represent —CH—; or
one of Z1, Z2 and Z3 represents N, one of Z1, Z2 and Z3 represents —CH—, and one of Z1, Z2 and Z3 represents —CR1—;
R1 represents H, halogen atom, CN, or heterocycloalkyl;
n is 0 or 1;
and acid addition salts thereof.

US Pat. No. 10,138,242

PYRAZOLOPYRIDINE DERIVATIVES AND THEIR USE IN THERAPY

1. A compound selected from the group consisting of a pyrazolopyridine derivative having the general formula (Ia) or (Ib)and solvates, salts, complexes, polymorphs, crystalline forms, racemic mixtures, diastereomers, enantiomers, tautomers, isotopically labeled forms, prodrugs, and combinations thereof,wherein
R1 is selected from the group consisting of —H, alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, heterocyclyl, —S(O)1-2R11, —S(O)1-2OR11, —S(O)1-2N(R12)(R13), —C(?X)R11, and —C(?X)XR11, wherein each of the alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, and heterocyclyl groups is optionally substituted with one or more independently selected R30 or the alkyl group is substituted with one R31;
R2 is selected from the group consisting of —H, alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, heterocyclyl, —S(O)1-2R11, —S(O)1-2OR11, —S(O)1-2N(R12)(R13), —C(?X)R11, and —C(?X)XR11, wherein each of the alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, and heterocyclyl groups is optionally substituted with one or more independently selected R30 or the alkyl group is substituted with one R31;
R3 is selected from the group consisting of aryl, heteroaryl, cycloalkyl, and heterocyclyl, wherein each of the aryl, heteroaryl, cycloalkyl, and heterocyclyl groups is optionally substituted with one or more independently selected R30;
R4, R?4, R6, R?6, R7, and R?7 are independently selected from the group consisting of H, alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, heterocyclyl, halogen, —CN, azido, —NO2, —OR11, —N(R12)(R13), —N(R11)(OR11), —S(O)0-2R11, —S(O)1-2OR11, —OS(O)1-2R11, —OS(O)1-2OR11, —S(O)1-2N(R12)(R13), —OS(O)1-2N(R12)(R13), —N(R11)S(O)1-2R11, —NR11S(O)1-2OR11, —NR11S(O)1-2N(R12)(R13), —C(?X)R11, —C(?X)XR11, —XC(?X)R11, and —XC(?X)XR11, wherein each of the alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, and heterocyclyl groups is optionally substituted with one or more independently selected R30;
R5 is selected from the group consisting of aryl, heteroaryl, cycloalkyl, and heterocyclyl, wherein each of the aryl, heteroaryl, cycloalkyl, and heterocyclyl groups is optionally substituted with one or more independently selected R30;
L3 is —C(O)—N(R8)-(alkylene)-, wherein the alkylene group is optionally substituted with one or more independently selected R30;
L5 is —Y3-(alkylene)o-, wherein Y3 is selected from the group consisting of —C(?X)—, —S(O)1-2—, and —S(O)1-2N(R9)—; o is 0 or 1; and each of the alkylene groups is optionally substituted with one or more independently selected R30;
R8 is selected from the group consisting of —H, alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heteroaryl, heterocyclyl, —OR11, and —NHR20, wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heteroaryl, and heterocyclyl groups is optionally substituted with one or more independently selected R30, or R8 and R2 may join together with the atoms to which they are attached to form a ring which is optionally substituted with one or more independently selected R30 or R8 and R3 may join together with the atoms to which they are attached to form a polycyclic ring which is optionally substituted with one or more independently selected R30;
R9 is selected from the group consisting of —H, alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heteroaryl, heterocyclyl, —OR11, and —NHR20, wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heteroaryl, and heterocyclyl groups is optionally substituted with one or more independently selected R30;
R10 is selected from the group consisting of —H, alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heteroaryl, heterocyclyl, —OR11, and —NHR20, wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heteroaryl, and heterocyclyl groups is optionally substituted with one or more independently selected R30;
X is independently selected from O, S, and N(R14);
R11 is, in each case, selected from the group consisting of —H, alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heteroaryl, and heterocyclyl, wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heteroaryl, and heterocyclyl groups is optionally substituted with one or more independently selected R30;
R12 and R13 are, in each case, independently selected from the group consisting of —H, alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heteroaryl, and heterocyclyl, or R12 and R13 may join together with the nitrogen atom to which they are attached to form the group —N?CR15R16, wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heteroaryl, and heterocyclyl groups is optionally substituted with one or more independently selected R30;
R14 is independently selected from the group consisting of —H, alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heteroaryl, heterocyclyl, and —OR11, wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heteroaryl, and heterocyclyl groups is optionally substituted with one or more independently selected R30;
R15 and R16 are independently selected from the group consisting of —H, alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heteroaryl, heterocyclyl, and —NHyR202-y, or R15 and R16 may join together with the atom to which they are attached to form a ring which is optionally substituted with one or more independently selected R30, wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heteroaryl, and heterocyclyl groups is optionally substituted with one or more independently selected R30 ;
y is an integer from 0 to 2;
R20 is selected from the group consisting of alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heteroaryl, and heterocyclyl, wherein each of the alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heteroaryl, and heterocyclyl groups is optionally substituted with one or more independently selected R30;
R30 is a 1st level substituent and is, in each case, independently selected from the group consisting of alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, heterocyclyl, halogen, —CN, azido, —NO2, —OR71, —N(R72)(R73), —S(O)0-2R71, —S(O)1-2OR71, —OS(O)1-2R71, —OS(O)1-2OR71, —S(O)1-2N(R72)(R73), —OS(O)1-2N(R72)(R73), —N(R71)S(O)1-2R71, —NR71S(O)1-2OR71, —NR71S(O)1-2N(R72)(R73), —C(?X1)R71, —C(?X1)X1R71, —X1C(?X1)R71, and —X1C(?X1)X1R71, and/or any two R30 which are bound to the same carbon atom of a cycloalkyl or heterocyclyl group may join together to form ?X1, wherein each of the alkyl, alkenyl, alkynyl, aryl, heteroaryl, cycloalkyl, and heterocyclyl groups being a 1st level substituent is optionally substituted by one or more 2nd level substituents, wherein said 2nd level substituent is, in each case, independently selected from the group consisting of C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, 3- to 14-membered aryl, 3- to 14-membered heteroaryl, 3- to 14-membered cycloalkyl, 3- to 14-membered heterocyclyl, halogen, —CF3, —CN, azido, —NO2, —OR81, —N(R82)(R83), —S(O)0-2R81, —S(O)1-2OR81, —OS(O)1-2R81, —OS(O)1-2OR81, —S(O)1-2N(R82)(R83), —OS(O)1-2N(R82)(R83, —N(R81)S(O)1-2R81, —NR81S(O)1-2OR81, —NR81S(O)1-2N(R82)(R83), —C(?X2)R81, —C(?X2)X2R81, —X2C(?X2)R81, and —X2C(?X2)R81, and/or any two 2nd level substituents which are bound to the same carbon atom of a cycloalkyl or heterocyclyl group being a 1st level substituent may join together to form ?X2, wherein each of the C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, 3- to 14-membered aryl, 3- to 14-membered heteroaryl, 3- to 14-membered cycloalkyl, 3- to 14-membered heterocyclyl groups being a 2nd level substituent is optionally substituted with one or more 3rd level substituents, wherein said 3rd level substituent is, in each case, independently selected from the group consisting of C1-3 alkyl, halogen, —CF3, —CN, azido, —NO2, —OH, —O(C1-3 alkyl), —OCF3, —S(C1-3 alkyl), —NH2, —NH(C1-3 alkyl), —N(C1-3 alkyl2, —NHS(O)2(C1-3 alkyl), —S(O)2NH2-z(C1-3 alkyl)z, —C(?O)OH, —C(?O)O(C1-3 alkyl), —C(?O)NH2-z(C1-3 alkyl)z, —NHC(?O)(C1-3 alkyl), —NHC(?NH)NHz-2(C1-3 alkyl)z, and —N(C1-3 alkyl)C(?NH)NH2-z(C1-3 alkyl)z, wherein z is 0, 1, or 2 and C1-3 alkyl is methyl, ethyl, propyl or isopropyl, and/or any two 3rd level substituents which are bound to the same carbon atom of a 3- to 14-membered cycloalkyl or heterocyclyl group being a 2nd level substituent may join together to form ?O, ?S, ?NH, or ?N(C1-3 alkyl);
wherein
R71, R72, and R73 are independently selected from the group consisting of —H, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, 3- to 7-membered cycloalkyl, 5- or 6-membered aryl, 5- or 6-membered heteroaryl, and 3- to 7-membered heterocyclyl, wherein each of the C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, 3- to 7-membered cycloalkyl, 5- or 6-membered aryl, 5- or 6-membered heteroaryl, and 3- to 7-membered heterocyclyl groups is optionally substituted with one, two or three substituents selected from the group consisting of C1-3 alkyl, 3- to 7-membered cycloalkyl, 5- or 6-membered aryl, 5- or 6-membered heteroaryl, and 3- to 7-membered heterocyclyl, halogen, —CF3, —CN, azido, —NO2, —OH, —O(C1-3 alkyl), —OCF3, ?O, —S(C1-3 alkyl), —NH2, —NH(C1-3 alkyl), —N(C1-3 alkyl)2, —NHS(O)2(C1-3 alkyl), —S(O)2NH2-z(C1-3 alkyl)z, —C(?O)(C1-3 alkyl), —C(?O)OH, —C(?O)O(C1-3 alkyl), —C(?O)NH2-z(C1-3 alkyl)z, —NHC(?O)(C1-3 alkyl), —NHC(?NH)NHz-2(C1-3 alkyl)z, and —N(C1-3 alkyl)C(?NH)NH2-z(C1-3 alkyl)z, wherein z is 0, 1, or 2 and C1-3 alkyl is methyl, ethyl, propyl or isopropyl;
R81, R82, and R83 are independently selected from the group consisting of —H, C1-4 alkyl, C2-4 alkenyl, C2-4 alkynyl, 3- to 6-membered cycloalkyl, 5- or 6-membered aryl, 5- or 6-membered heteroaryl, and 3- to 6-membered heterocyclyl, wherein each of the C1-4alkyl, C2-4 alkenyl, C2-4 alkynyl, 3- to 6-membered cycloalkyl, 5- or 6-membered aryl, 5- or 6-membered heteroaryl, and 3- to 6-membered heterocyclyl groups is optionally substituted with one, two or three substituents selected from the group consisting of C1-3 alkyl, halogen, —CF3, —CN, azido, —NO2, —OH, —O(C1-3 alkyl), —OCF3, ?O, —S(C1-3 alkyl), —NH2, —NH(C1-3 alkyl), —N(C1-3 alkyl)2, —NHS(O)2(C1-3 alkyl), —S(O)2NH2-z(C1-3 alkyl)z, —C(?O)(C1-3 alkyl), —C(?O)OH, —C(?O)O(C1-3 alkyl), —C(?O)NH2-z(C1-3 alkyl)z, —NHC(?O)(C1-3 alkyl), —NHC(?NH)NHz-2(C1-3 alkyl)z, and —N(C1-3 alkyl)C(?NH)NH2-z(C1-3 alkyl)z, wherein z is 0, 1, or 2 and C1-3 alkyl is methyl, ethyl, propyl or isopropyl;
X1 and X2 are independently selected from O, S, and N(R81); and
R31 is —Y4—B or —B, wherein Y4 is selected from the group consisting of —X—, —C(?X)-(alkylene)p-, —C(?X)X-(alkylene)p-, —XC(?X)-(alkylene)p-, —XC(?X)X-(alkylene)p-, —[O—(C1-3 alkylene)]n, —[S—(C1-3 alkylene)]n, —[N(R10)—(C1-3alkylene)]n, —S(O)1-2-(alkylene)p-, —OS(O)1-2-(alkylene)p-, —OS(O)1-2-(alkylene)p-, —S(O)1-2N(R9)-(alkylene)p-, —OS(O)1-2N(R9)-(alkylene)p-, —N(R9)S(O)1-2-(alkylene)p-, —N(R9)S(O)1-2O-(alkylene)p-, and —N(R9)S(O)1-2N(R9)-(alkylene)p-, wherein p is 0 or 1; and B is a molecular probe.

US Pat. No. 10,138,241

SUBSTITUTED BENZAMIDES AS RIPK2 INHIBITORS

Boehringer Ingelheim Inte...

21. A compound selected from the group consisting of:
or the pharmaceutically acceptable salts thereof.

US Pat. No. 10,138,240

CRYSTAL OF 5-HYDROXY-4-(TRIFLUOROMETHYL)PYRAZOLOPYRIDINE DERIVATIVE

Daiichi Sankyo Company, L...

1. A crystal of a compound represented by formula (I) or a pharmacologically acceptable salt thereof:
wherein R1 represents a hydrogen atom or a hydroxy group, and R represents a 2-(trifluoromethyl)pyrimidin-5-yl group or a 5-(trifluoromethyl)pyrazin-2-yl group.

US Pat. No. 10,138,235

PYRAZOLOPYRIDINE DERIVATIVES, PREPARATION PROCESS THEREFOR AND THERAPEUTIC USE THEREOF

SANOFI, Paris (FR)

1. A compound of formula (I?) or (I?):
wherein
R1 is phenyl substituted with one or more substituents chosen from —CF3, cyano, —NR6R6?, —NR10R11 wherein R10 and R11 form, together with the nitrogen atom to which they are attached, a saturated or unsaturated heterocycle comprising one or more heteroatoms chosen from a nitrogen atom and an oxygen atom, optionally substituted with one or more substituents chosen from halogen and linear or branched alkyl, —CH2NR10R11 wherein R10 and R11 form, together with the nitrogen atom to which they are attached, a saturated or unsaturated heterocycle comprising one or more heteroatoms chosen from a nitrogen atom and an oxygen atom, —COR12 wherein R12 is hydroxyl or —NR6R6?, —CONR7R7? wherein R7 and R7? form, together with the nitrogen atom to which they are attached, a heterocycloalkyl comprising one or more heteroatoms chosen from a nitrogen atom and an oxygen atom, —(CH2)pNHSO2CH3 wherein p is 0 or 1, —OR13 wherein R13 is linear (C2-C3)alkyl, and (C3)alkyl,
or R1 is pyridyl optionally substituted with one or more substituents chosen from fluorine, —CF3, cyano, —NR6R6?, —NR10R11 wherein R10 and R11 form, together with the nitrogen atom to which they are attached, a saturated or unsaturated heterocycle comprising one or more heteroatoms chosen from a nitrogen atom and an oxygen atom, optionally substituted with one or more substituents chosen from halogen and linear or branched alkyl, —CH2NR10R11 wherein R10 and R11 form, together with the nitrogen atom to which they are attached, a saturated or unsaturated heterocycle comprising one or more heteroatoms chosen from a nitrogen atom and an oxygen atom, —COR12 wherein R12 is hydroxyl or —NR6R6?, —CONR7R7? wherein R7 and R7? form, together with the nitrogen atom to which they are attached, a heterocycloalkyl comprising one or more heteroatoms chosen from a nitrogen atom and an oxygen atom, —(CH2)pNHSO2CH3 wherein p is 0 or 1, —OR13 wherein R13 is linear (C1-C3)alkyl, and (C2-C3)alkyl,
or R1 is pyrazolyl optionally substituted with one or more substituents chosen from fluorine, —CF3, cyano, —NR6R6?, —NR10R11 wherein R10 and R11 form, together with the nitrogen atom to which they are attached, a saturated or unsaturated heterocycle comprising one or more heteroatoms chosen from a nitrogen atom and an oxygen atom, optionally substituted with one or more substituents chosen from halogen and linear or branched alkyl, —CH2NR10R11 wherein R10 and R11 form together with the nitrogen atom to which they are attached, a saturated or unsaturated heterocycle comprising one or more heteroatoms chosen from a nitrogen atom and an oxygen atom, —COR12 wherein R12 is hydroxyl or —NR6R6?, —CONR7R7? wherein R7 and R7? form, together with the nitrogen atom to which they are attached, a heterocycloalkyl comprising one or more heteroatoms chosen from a nitrogen atom and an oxygen atom, —(CH2)pNHSO2CH3 wherein p is 0 or 1, —OR13 wherein R13 is linear (C1-C3)alkyl, and (C3)alkyl,
or R1 is a bicyclic group of formula A:

wherein R8 and R9 form, together with the phenyl ring to which they are attached, a dihydrobenzimidazolonyl, indolyl, dihydrobenzoxazinyl, benzothiazolyl or benzimidazolyl, optionally substituted with one or more linear alkyl groups;
R2 is —CF3, —CHF2, or —CONHR5;
R3 is hydrogen, aryl optionally substituted with alkoxymethyl, or heteroaryl chosen from thienyl and pyridyl;
R4 is hydrogen, (C1)alkyl, linear (C3)alkyl, or linear (C1-C3)alkyl substituted with —NR6R6? or —NR7R7? wherein R7 and R7? form, together with the nitrogen atom to which they are attached, a heterocycloalkyl comprising one or more heteroatoms chosen from a nitrogen atom and an oxygen atom;
R5 is
hydrogen,
linear (C1-C3)alkyl optionally substituted with pyridyl, or
an aromatic group chosen from aryl and pyridyl; and
R6 and R6?, are independently hydrogen or a linear alkyl group, in the form of the base or of an acid-addition or base-addition salt.

US Pat. No. 10,138,233

IMIDAZOLE COMPOUNDS AS MODULATORS OF FSHR AND USES THEREOF

Merck Patent GmbH, Darms...

1. A compound of formula I,
X is CR2, or O;
Y is O, S, or NR;
Z is N;
each R is independently hydrogen, C1-6 aliphatic, C3-10 aryl, a 3-8 membered saturated or partially unsaturated carbocyclic ring, a 3-7 membered heterocylic ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur, or a 5-6 membered monocyclic heteroaryl ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur; each of which is optionally substituted; or
two R groups on the same atom are taken together with the atom to which they are attached to form a C3-10 aryl, a 3-8 membered saturated or partially unsaturated carbocyclic ring, a 3-7 membered heterocylic ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur, or a 5-6 membered monocyclic heteroaryl ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur; each of which is optionally substituted;
Ring A is a fused C3-10 aryl, a fused 3-8 membered saturated or partially unsaturated carbocyclic ring, a fused 3-7 membered heterocylic ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur, or a fused 5-6 membered monocyclic heteroaryl ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur;
R1 is —OR, —SR, —CN, —NO2, —SO2R, —SOR, —C(O)R, —CO2R, —C(O)N(R)2, —NRC(O)R, —NRC(O)N(R)2, —NRSO2R, or —N(R)2;
R2 is —R, -haloalkyl, —OR, —SR, —CN, —NO2, —SO2R, —SOR, —C(O)R, —CO2R, —C(O)N(R)2, —NRC(O)R, —NRC(O)N(R)2, —NRSO2R, or —N(R)2;
R3 is C1-6 aliphatic, C3-10 aryl, a 3-8 membered saturated or partially unsaturated carbocyclic ring, a 3-7 membered heterocylic ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur, or a 5-6 membered monocyclic heteroaryl ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur; each of which is optionally substituted; or R3 is halogen, -haloalkyl, —OR, —SR, —CN, —NO2, —SO2R, —SOR, —C(O)R, —CO2R, —C(O)N(R)2, —NRC(O)R, —NRC(O)N(R)2, —NRSO2R, or —N(R)2;
each R4 is independently —R, halogen, -haloalkyl, —OR, —SR, —CN, —NO2, —SO2R, —SOR, —C(O)R, —CO2R, —C(O)N(R)2, —NRC(O)R, —NRC(O)N(R)2, —NRSO2R, or —N(R)2;
R5 is C1-6 aliphatic, C3-10 aryl, a 3-8 membered saturated or partially unsaturated carbocyclic ring, a 3-7 membered heterocylic ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur, or a 5-6 membered monocyclic heteroaryl ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur; each of which is optionally substituted;
R6 is hydrogen, C1-6 aliphatic, C3-10 aryl, a 3-8 membered saturated or partially unsaturated carbocyclic ring, a 3-7 membered heterocylic ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur, or a 5-6 membered monocyclic heteroaryl ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur; each of which is optionally substituted;
or R5 and R6, together with the atom to which each is attached, form a 3-8 membered heterocylic ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur, or a 3-8 membered heteroaryl ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur; each of which is optionally substituted;
n is 0, 1, or 2; and
p is 1.

US Pat. No. 10,138,230

AUTOTAXIN INHIBITORS

Cancer Research Technolog...

1. A compound, or a pharmaceutically acceptable salt thereof, having the structural formula (I) shown below:
wherein:
R1 and R2 are independently selected from H, (1-8C)alkyl, (4-7C)cycloalkyl, 4-7 membered heterocyclyl, 5-6 membered heteroaryl, —S(O)yRa or C(O)Ra, wherein Ra is selected from H, (1-4C)alkyl or (1-4C)alkoxy, y is 0, 1 or 2, and wherein any (1-8C)alkyl, (4-7C)cycloalkyl, 4-7 membered heterocyclyl or 5-6 membered heteroaryl is optionally substituted by one or more substituents selected from oxo, (1-4C)alkyl, halo, cyano, nitro, hydroxyl, amino, (1-4C)haloalkyl, (1-4C)alkoxy, (1-4C)haloalkoxy, carboxyl, carbamoyl, sulphamoyl, NRbRc, ORb, C(O)Rb, C(O)ORb, OC(O)Rb, C(O)N(Rb)Rc, N(Rb)C(O)Rc, S(O)yRb (where y is 0, 1 or 2), SO2N(Rb)Rc, N(Rb)SO2Rc or (CH2)zNRbRc (where z is 1, 2 or 3), (4-6C)heterocycyl, 6 membered aryl or 5 or 6 membered heteroaryl, wherein Rb and Rc are each independently selected from H or (1-4C)alkyl; or
R1 and R2 are linked such that, together with the nitrogen atom to which they are attached, they form a 4 to 10 membered mono or bicyclic heterocyclic ring which is optionally substituted by one or more substituents selected from oxo, (1-4C)alkyl, halo, cyano, nitro, hydroxyl, amino, (1-4C)haloalkyl, (1-4C)alkoxy, (1-4C)haloalkoxy, carboxyl, carbamoyl, sulphamoyl, NRdRe, ORd, C(O)Rd, C(O)ORd, OC(O)Rd, C(O)N(Re)Rd, N(Re)C(O)Rd, S(O)yRd (where y is 0, 1 or 2), SO2N(Re)Rd, N(Re)SO2Rd or (CH2)zNRdRe (where z is 1, 2 or 3), (4-6C)heterocycyl, 6 membered aryl or 5 or 6 membered heteroaryl, wherein Rd and Re are each independently selected from H or (1-4C)alkyl;
L is a (1-3C)alkylene optionally substituted by fluoro, (1-2C)alkyl or oxo;
R4a, R4b, R4c and R4d are each independently selected from H, halo, (1-2C)alkyl, cyano, nitro, hydroxyl, amino, (1-2C)haloalkyl, (1-2C)alkoxy, or (1-2C)haloalkoxy;
A is C(?X) or CRfRg;
wherein X is O, NH or S; and
Rf and Rg are independently selected from H or (1-2C)alkyl;
Q is selected from —NH—S(O)y—, —S(O)y—NH—, —C(O)NRh—, —NRhC(O)—, —NRh—S(O)(NH)—, —S(O)(NH)—NRh—, —C(O)O—, —OC(O)—, —CH2CH2—, —CH2NRh— or —NRhCH2—, wherein y is 0, 1 or 2 and Rh is selected from H or (1-2C)alkyl;
HET is a 5 or 6 membered nitrogen containing heteroaryl optionally substituted with one or more substituents selected from H, (1-4C)alkyl, halo, cyano, nitro, hydroxyl, amino, (1-4C)haloalkyl, (1-4C)alkoxy, (1-4C)haloalkoxy, carboxyl, carbamoyl, amido or sulphamoyl;
W is either a group of the formula:
-Q1-Ri—
wherein:
Q1 is attached to HET and is —C(O)— or —CH2—; and
Ri is attached to R3 and is selected from —CHRj—, —NRj—, or —O—, wherein Rj is selected from H or (1-2C)alkyl;
or W is a group of the formula:
Rk-Q2-
wherein:
Q2 is attached to R3 and is selected from —C(O)— or —CH2—; and
Rk is attached to HET and is selected from CHRl, NRl, O or S(O)y, wherein y is 0, 1 or 2 and R is H or (1-4C)alkyl;
R3 is selected from (1-6C)alkyl, phenyl, (4-8C)carbocyclyl, heteroaryl or heterocyclyl, each of which is optionally substituted with one or more substituents selected from (1-4C)alkyl, halo, (1-4C)haloalkyl, (1-4C)alkoxy, (1-4C)haloalkoxy, (3-6C)cycloalkyl, (3-6C)cycloalkyl(1-2C)alkyl, (2-4C)alkenyl or (2-4C)alkynyl.

US Pat. No. 10,138,229

HETEROAROMATIC COMPOUNDS AS BTK INHIBITORS

Boehringer Ingelheim Inte...

1. A compound chosen from:or a pharmaceutically acceptable salt thereof.

US Pat. No. 10,138,227

HETEROARYL SUBSTITUTED PYRIDINES AND METHODS OF USE

Galapagos NV, Mechelen (...

1. A compound of Formula I, or a pharmaceutically acceptable salt thereof,whereinX1 and X2 are independently selected
H;
halo;
C1-4 alkyl optionally substituted with one or more independently selected halo;
C1-4 alkoxy optionally substituted with one or more independently selected
—OH;
C1-4 alkoxy; or
—NR8AR8B;
—NR9AR8B;
cyclopropyl optionally substituted with one or more independently selected R5 groups;
phenoxy optionally substituted with one or more independently selected R5 groups; or
phenyl optionally substituted with one or more independently selected R5 groups;
R1 is
C1-4 alkyl optionally substituted with one or more independently selected
—OH;
C1-4 alkoxy; or
4-6 membered monocyclic heterocycle comprising 1 or 2 heteroatoms independently selected from the group consisting of O, S, and N;
phenyl optionally substituted with one or more independently selected R4 groups;
N-linked 4-6 membered monocyclic heterocycle comprising 1, 2, or 3 heteroatoms independently selected from the group consisting of N, O, and S, wherein the monocyclic heterocycle is optionally substituted with one or more independently selected R5 groups;
N-linked 4-6 membered monocyclic heterocycle comprising 1, 2, or 3 heteroatoms independently selected from the group consisting of N, O, and S, fused to a phenyl, wherein the monocyclic heterocycle and the phenyl are optionally substituted with one or more independently selected R5 groups;
C3-7 cycloalkyl optionally substituted with one or more independently selected R5 groups; or
—NR6R7;
R2 is 5-6 membered monocyclic heteroaryl comprising 1, 2, or 3 heteroatoms independently selected from the group consisting of O, S, and N, wherein the monocyclic heteroaryl is optionally substituted with one or more independently selected R3 groups;
each R3 is independently selected from the group consisting of:
C1-4 alkyl optionally substituted with one or more independently selected
C3-7 cycloalkyl; wherein the C3-7 cycloalkyl is optionally substituted with one or more independently selected RA groups;
4-6 membered monocyclic heterocycle comprising 1 or 2 heteroatoms independently selected from the group consisting of O, S, and N; wherein the monocyclic heterocycle is optionally substituted with one or more independently selected RA groups;
phenyl; wherein the phenyl is optionally substituted with one or more independently selected RA groups;
C1-4 alkoxy optionally substituted with one or more independently selected C3-7 cycloalkyl, halo, or —OCH3;
—OR11
—OH;
halo;
—CN;
—OC(O)R10;
—OS (O)2OH;
—NHC(?S)R11; or
—OP(O)(OH)(OH);
—C(O)NH2;
phenyl; wherein the phenyl is optionally substituted with one or more independently selected RA groups;
5-6 membered monocyclic heteroaryl comprising 1, 2, or 3 heteroatoms independently selected from the group consisting of O, S, and N; wherein the monocyclic heteroaryl is optionally substituted with one or more independently selected RA groups;
C3-7 cycloalkyl; wherein the C3-7 cycloalkyl is optionally substituted with one or more independently selected RA groups; and
4-6 membered monocyclic heterocycle comprising 1 or 2 heteroatoms independently selected from the group consisting of O, S, and N; wherein the monocyclic heterocycle is optionally substituted with one or more independently selected RA groups;
each R4 is independently selected from the group consisting of:
halo;
C1-4 alkyl optionally substituted with one or more independently selected halo; and
C1-4 alkoxy optionally substituted with one or more independently selected halo;
each R5 is independently selected from the group consisting of:
—OH;
halo;
C1-4 alkyl optionally substituted with one or more independently selected C1-4 alkoxy, halo or —OH; and
C1-4 alkoxy optionally substituted with one or more independently selected halo;
R6 is H, C3-7 alkyl, or C3-7 cycloalkyl wherein the C3-7 cycloalkyl is optionally substituted with one or more independently selected R5 groups;
R7 is
C1-4 alkyl optionally substituted with one or more independently selected halo;
phenyl optionally substituted with one or more independently selected halo;
C1-4 alkyl optionally substituted with one or more independently selected halo; or
C1-4 alkoxy optionally substituted with one or more independently selected halo;
C1-4 alkoxy optionally substituted with one or more independently selected halo; or
4-6 membered monocyclic heterocycle comprising 1 or 2 heteroatoms independently selected from the group consisting of O, S, and N; wherein the monocyclic heterocycle is optionally substituted with one or more independently selected R5 groups;
each R8a and R8b is independently selected from the group consisting of
H; and
C1-4 alkyl;
R9a and R9b are independently selected from the group consisting of
H;
C1-4 alkyl; and
C3-7 cycloalkyl; and
each R10 is independently selected from the group consisting of
C1-6 alkyl; and
phenyl; wherein phenyl is optionally substituted with one or more independently selected RA groups;
each R11 is independently selected from the group consisting of
4-6 membered monocyclic heterocycle comprising 1 or 2 heteroatoms independently selected from the group consisting of O, S, and N; wherein the monocyclic heterocycle is optionally substituted with one or more independently selected RA groups;
5-6 membered monocyclic heteroaryl comprising 1, 2, or 3 heteroatoms independently selected from the group consisting of O, S, and N; wherein the monocyclic heteroaryl is optionally substituted with one or more independently selected RA groups;
C3-7 cycloalkyl; wherein the C3-7 cycloalkyl is optionally substituted with one or more independently selected RA groups; and
phenyl; wherein phenyl is optionally substituted with one or more independently selected RA groups; and
each RA is independently selected from the group consisting of
—CN,
halo;
C1-4 alkyl optionally substituted with one or more independently selected halo; and
C1-4 alkoxy optionally substituted with one or more independently selected halo.

US Pat. No. 10,138,225

AMIDE COMPOUNDS FOR TREATMENT OF MEDICAL DISORDERS

Achillion Pharmaceuticals...

1. A method for the treatment of a disorder mediated by complement factor D, comprising administering an effective amount to a host in need thereof a compound of Formula (I)or a pharmaceutically acceptable salt thereof, wherein:Q1 is C(R1R1?);
Q2 is C(R2R2?);
Q3 is C(R3R3?);
X1 is N and X2 is CH;
R1, R1?, R2, R2?, R3, and R3? are independently selected from hydrogen, halogen, hydroxyl, nitro, cyano, amino, C1-C6alkyl, C2-C6alkenyl, C2-C6alkynyl, C1-C6alkoxy, C2-C6alkynyl, C2-C6alkanoyl, C1-C6thioalkyl, hydroxyC1-C6alkyl, aminoC1-C6alkyl, —C0-C4alkylNR9R10, —C(O)OR9, —OC(O)R9, —NR9C(O)R10, —C(O)NR9R10, —OC(O)NR9R10, —NR9C(O)OR10, C1-C2haloalkyl, and C1-C2haloalkoxy;
R9 and R10 are independently selected from hydrogen, C1-C6alkyl, (C3-C7cycloalkyl)C0-C4alkyl, —C0-C4alkyl(C3-C7cycloalkyl), and —O—C0-C4alkyl(C3-C7cycloalkyl);
or R1 and R2 are linked to form a 3- to 6-membered carbocyclic or aryl ring;
or R2 and R3 are linked to form a 3- to 6-membered carbocyclic ring;
or R1 and R1?, or R2 and R2?, or R3 and R3? are linked to form a 3- to 6-membered carbocyclic spiro ring;
or R1 and R1?, or R2 and R2?, or R3 and R3? are linked to form a 3- to 6-membered heterocyclic spiro ring;
each of which ring is unsubstituted or substituted with one or more substituents independently selected from halogen, hydroxyl, cyano, —COOH, C1-C4alkyl, C2-C4alkenyl, C2-C4alkynyl, C1-C4alkoxy, C2-C4alkanoyl, hydroxyC1-C4alkyl, (mono- and di-C1-C4alkylamino)C0-C4alkyl, —C0-C4alkyl(C3-C7cycloalkyl), —O—C0-C4alkyl(C3-C7cycloalkyl), C1-C2haloalkyl, and C1-C2haloalkoxy;
or R1 and R1? or R2 and R2? are taken together to form a carbonyl group;
A is a group selected from:

R5 and R6 are independently selected from —CHO, —C(O)NH2, —C(O)NH(CH3), C2-C6alkanoyl, hydrogen, hydroxyl, halogen, cyano, nitro, —COOH, —SO2NH2, vinyl, C1-C6alkyl, C2-C6alkenyl, C1-C6alkoxy, —C0-C4alkyl(C3-C7cycloalkyl), —C(O)C0-C4alkyl(C3-C7cycloalkyl), —P(O)(OR9)2, —OC(O)R9, —C(O)OR9, —C(O)N(CH2CH2R9)(R10), —NR9C(O)R10, phenyl, and 5- to 6-membered heteroaryl;
R8 and R8? are independently selected from hydrogen, halogen, hydroxyl, C1-C6alkyl, —C0-C4alkyl(C3-C7cycloalkyl), C1-C6alkoxy, and (C1-C4alkylamino)C0-C2alkyl; or R8 and R8? are taken together to form an oxo group; or R8 and R8? can be taken together with the carbon that they are bonded to form a 3-membered carbocyclic ring;
X11 is N or CR11;
X12 is CR12;
X13 is CR13;
X14 is N or CR14;
one of R12 and R13 is selected from R31 and the other of R12 and R13 is selected from R32;
R31 is selected from hydrogen, halogen, hydroxyl, nitro, cyano, amino, —COOH, C1-C2haloalkyl, C1-C2haloalkoxy, C1-C6alkyl, —C0-C4alkyl(C3-C7cycloalkyl), C2-C6alkenyl, C2-C6alkanoyl, C1-C6alkoxy, C2-C6alkenyloxy, —C(O)OR9, C1-C6thioalkyl, —C0-C4alkylNR9R10, —C(O)NR9R10, —SO2R9, —SO2NR9R10, —OC(O)R9, and —C(NR9)NR9R10, each of which R31 other than hydrogen, halogen, hydroxyl, nitro, cyano, C1-C2haloalkyl, and C1-C2haloalkoxy is unsubstituted or substituted with one or more substituents independently selected from halogen, hydroxyl, nitro, cyano, amino, —COOH, —CONH2C1-C2haloalkyl, and C1-C2haloalkoxy, and each of which R31 is also optionally substituted with one substituent selected from phenyl and 4- to 7-membered heterocycle containing 1, 2, or 3 heteroatoms independently selected from N, O, and S; which phenyl or 4- to 7-membered heterocycle is unsubstituted or substituted with one or more substituents independently selected from halogen, hydroxyl, nitro, cyano, C1-C6alkyl, C2-C6alkenyl, C2-C6alkanoyl, C1-C6alkoxy, (mono- and di-C1-C6alkylamino)C0-C4alkyl, C1-C6alkylester, —C0-C4alkyl)(C3-C7cycloalkyl), C1-C2haloalkyl, and C1-C2haloalkoxy;
R32 is selected from —C(O)NR21SO2R22, —NR9C(O)OR10, —NR9C(O)OR23, —NR9C(O)R21, —NR9C(O)NR9R10, —NR9C(O)NR10R23, and —NR9C(O)NR24R25;
R11 and R14 are independently selected from hydrogen, halogen, hydroxyl, nitro, cyano, —O(PO)(OR9)2, —(PO)(OR9)2, C1-C6alkyl, C2-C6alkenyl, C2-C6alkynyl, C2-C6alkenyl(aryl), C2-C6alkenyl(cycloalkyl), C2-C6alkenyl(heterocycle), C2-C6alkenyl(heteroaryl), C2-C6alkynyl, C2-C6alkynyl(aryl), C2-C6alkynyl(cycloalkyl), C2-C6alkynyl(heterocycle), C2-C6alkynyl(heteroaryl), C2-C6alkanoyl, C1-C6alkoxy, C1-C6thioalkyl, —C0-C4alkyl(mono- and di-C1-C6alkylamino), —C0-C4alkyl(C3-C7cycloalkyl), —C0-C4alkoxy(C3-C7cycloalkyl), C1-C2haloalkyl, and C1-C2haloalkoxy;
R21 and R22 are independently selected from hydrogen, hydroxyl, cyano, amino, C1-C6alkyl, C1-C6haloalkyl, C1-C6alkoxy, (C3-C7cycloalkyl)C0-C4alkyl, (phenyl)C0-C4alkyl, —C1-C4alkylOC(O)OC1-C6alkyl, —C1-C4alkylOC(O)C1-C6alkyl, —C1-C4alkylC(O)OC1-C6alkyl, (4- to 7-membered heterocycloalkyl)C0-C4alkyl having 1, 2, or 3 heteroatoms independently selected from N, O, and S, and (5- or 6-membered unsaturated or aromatic heterocycle)C0-C4alkyl having 1, 2, or 3 heteroatoms independently selected from N, O, and S;
R23 is independently selected from C1-C6alkyl, C1-C6haloalkyl, (C3-C7cycloalkyl)C0-C4alkyl, (aryl)C0-C4alkyl, (4- to 7-membered heterocycloalkyl)C0-C4alkyl having 1, 2, or 3 heteroatoms independently selected from N, O, and S, and (5- or 6-membered unsaturated or aromatic heterocycle)C0-C4alkyl having 1, 2, or 3 heteroatoms independently selected from N, O, and S;
R24 and R25 are taken together with the nitrogen to which they are attached to form a 4- to 7-membered monocyclic heterocycloalkyl group, or a 6- to 10-membered bicyclic heterocyclic group having fused, spiro, or bridged rings and each R24 and R25;
L is

R17 is hydrogen, C1-C6alkyl, or —C0-C4alkyl(C3-C7cycloalkyl);
R18 and R18? are independently selected from hydrogen, halogen, hydroxymethyl, and methyl;
m is 0, 1, 2, or 3;
B is a monocyclic or bicyclic carbocyclic; a monocyclic or bicyclic carbocyclic-oxy group; a monocyclic, bicyclic, or tricyclic heterocyclic group having 1, 2, 3, or 4 heteroatoms independently selected from N, O, and S and from 4 to 7 ring atoms per ring; C2-C6alkenyl; C2-C6alkynyl; —(C0-C4alkyl)(aryl); —(C0-C4alkyl)(heteroaryl); or —(C0-C4alkyl)(biphenyl), and B is unsubstituted or substituted with one or more substituents independently selected from R33 and R34, and 0 or 1 substituents selected from R35 and R36;
R33 is selected from halogen, hydroxyl, —COOH, cyano, C1-C6alkyl, C2-C6alkanoyl, C1-C6alkoxy, —C0-C4alkylNR9R10, —SO2R9, C1-C2haloalkyl, and C1-C2haloalkoxy;
R34 is selected from nitro, C2-C6alkenyl, C2-C6alkynyl, C1-C6thioalkyl, -JC3-C7cycloalkyl, —B(OH)2, -JC(O)NR9R23, -JOSO2OR21, —C(O)(CH2)1-4S(O)R21, —O(CH2)1-4S(O)NR21R22, -JOP(O)(OR21)(OR22), -JP(O)(OR21)(OR22), -JOP(O)(OR21)R22, -JP(O)(OR21)R22, -JOP(O)R21R22, -JP(O)R21R22, -JSP(O)(OR21)(OR22), -JSP(O)(OR21)(R22), -JSP(O)(R21)(R22), -JNR9P(O)(NHR21)(NHR22), -JNR9P(O)(OR21)(NHR22), -JNR9P(O)(OR21)(OR22), -JC(S)R21, -JNR21SO2R22, -JNR9S(O)NR10R22, -JNR9SO2NR10R22, -JSO2NR9COR22, -JSO2NR9CONR21R22, -JNR21SO2R22, -JC(O)NR21SO2R22, -JC(NH2)NR22, -JC(NH2)NR9S(O)2R22, -JOC(O)NR21R22, -JNR21C(O)OR22, -JNR21OC(O)R22, —(CH2)1-4C(O)NR21R22, -JC(O)NR24R25, -JNR9C(O)R21, -JC(O)R21, -JNR9C(O)NR1R22, —CCR21, —(CH2)1-4OC(O)R21, and -JC(O)OR23; each of which R34 may be unsubstituted or substituted with one or more substituents independently selected from halogen, hydroxyl, nitro, cyano, amino, oxo, —B(OH)2, —Si(CH3)3, —COOH, —CONH2, —P(O)(OH)2, C1-C6alkyl, —C0-C4alkyl(C3-C7cycloalkyl), C1-C6alkoxy, —C0-C2alkyl(mono- and di-C1-C4alkylamino), C1-C6alkylester, C1-C4alkylamino, C1-C4hydroxylalkyl, C1-C2haloalkyl, and C1-C2haloalkoxy;
R35 is selected from naphthyl, naphthyloxy, indanyl, (4- to 7-membered heterocycloalkyl)C0-C4alkyl containing 1 or 2 heteroatoms selected from N, O, and S, and bicyclic heterocycle containing 1, 2, or 3 heteroatoms independently selected from N, O, and S, and containing 4- to 7-ring atoms in each ring; each of which R35 is unsubstituted or substituted with one or more substituents independently selected from halogen, hydroxyl, nitro, cyano, C1-C6alkyl, C2-C6alkenyl, C2-C6alkanoyl, C1-C6alkoxy, (mono- and di-C1-C6alkylamino)C0-C4alkyl, C1-C6alkylester, —C0-C4alkyl(C3-C7cycloalkyl), —SO2R9, C1-C2haloalkyl, and C1-C2haloalkoxy;
R36 is selected from tetrazolyl, (phenyl)C0-C2alkyl, (phenyl)C1-C2alkoxy, phenoxy, and 5- or 6-membered heteroaryl containing 1, 2, or 3 heteroatoms independently selected from N, O, B, and S, each of which R36 is unsubstituted or substituted with one or more substituents independently selected from halogen, hydroxyl, nitro, cyano, C1-C6alkyl, C2-C6alkenyl, C2-C6alkanoyl, C1-C6alkoxy, (mono- and di-C1-C6alkylamino)C0-C4alkyl, C1-C6alkylester, —C0-C4alkyl(C3-C7cycloalkyl), —SO2R9, —OSi(CH3)2C(CH3)3, —Si(CH3)2C(CH3)3, C1-C2haloalkyl, and C1-C2haloalkoxy; and
J is selected from a covalent bond, C1-C4alkylene, —OC1-C4alkylene, C2-C4alkenylene, and C2-C4alkynylene.

US Pat. No. 10,138,220

DIAMIDE COMPOUNDS HAVING MUSCARINIC RECEPTOR ANTAGONIS AND BETA2 ADRENERGIC RECEPTOR AGONIST ACTIVITY

Theravance Respiratory Co...

1. A pharmaceutical composition comprising an isotonic aqueous solution comprising from about 0.05 ?g/mL to about 10 mg/mL of a compound of formula I:
wherein
Y is a group of formula (a):

and Y is attached at the 3- or 4-position of the phenylene ring relative to the —CH2—(CR5R6)e— group;
X is selected from —C(O)NH— and —NHC(O)—;
Ar1 is selected from phen-1,3-ylene and phen-1,4-ylene, wherein the phenylene group is unsubstituted or substituted with 1 to 3 substituents selected independently from C1-3 alkyl, —O—(C1-3 alkyl) and halo;
each R1 is selected independently from C1-3 alkyl, —O—(C1-3 alkyl), hydroxyl and halo;
each R2 is selected independently from C1-3 alkyl, —O—(C1-3 alkyl) and halo;
each R3 is selected independently from C1-3 alkyl; or two R3 groups are joined to form C1-3 alkylene, C2-3 alkenylene or oxiran-2,3-diyl;
each R4 is selected independently from C1-3 alkyl, —O—(C1-3 alkyl) and halo;
R5 is selected from hydrogen, methyl and ethyl;
R6 is selected from hydrogen, methyl and ethyl;
Ra is selected from C1-6 alkyl;
a is 0, 1, 2 or 3;
b is 0, 1, 2 or 3;
c is 0, 1, 2, 3 or 4;
d is 0, 1, 2 or 3;
e is 0 or 1;
n is 0 or 1;
p is 0, 1, 2, 3, 4, 5 or 6; provided that when n is 0, p is 1, 2, 3, 4, 5 or 6;
q is 0, 1, 2, 3, 4, 5 or 6;
or a pharmaceutically acceptable salt thereof.

US Pat. No. 10,138,219

METHODS AND COMPOUNDS FOR RESTORING MUTANT P53 FUNCTION

PMV PHARMACEUTICALS, Cra...

1. A compound of the formula:wherein:Q1 is C1-alkylene; or a bond;
each R3 and R4 is independently, —C(O)R19, —C(O)OR19, —C(O)NR19R20, —SOR19, —SO2R19, alkyl, alkylene, alkenyl, alkenylene, alkynyl, aryl, heteroaryl, or heterocyclyl, each of which is independently substituted or -unsubstituted with a hydroxyl group, sulfhydryl group, halogen, amino group, nitro group, nitroso group, cyano group, azido group, sulfoxide group, sulfone group, sulfonamide group, carboxyl group, carboxaldehyde group, imine group, alkyl group, halo-alkyl group, alkenyl group, halo-alkenyl group, alkynyl group, halo-alkynyl group, alkoxy group, aryl group, aryloxy group, aralkyl group, arylalkoxy group, heterocyclyl group, acyl group, acyloxy group, carbamate group, amide group, ureido group, epoxy group, or an ester group; or hydrogen, or R3 and R4 together with the nitrogen atom to which R3 and R4 are bound form a ring, wherein the ring is substituted or unsubstituted with a hydroxyl group, sulfhydryl group, halogen, amino group, nitro group, nitroso group, cyano group, azido group, sulfoxide group, sulfone group, sulfonamide group, carboxyl group, carboxaldehyde group, imine group, alkyl group, halo-alkyl group, alkenyl group, halo-alkenyl group, alkynyl group, halo-alkynyl group, alkoxy group, aryl group, aryloxy group, aralkyl group, arylalkoxy group, heterocyclyl group, acyl group, acyloxy group, carbamate group, amide group, ureido group, epoxy group, or an ester group;
each R2, R13, R14, and R15, is independently —C(O)R21, —C(O)OR21, —C(O)NR21R22, —OR21, —SR21, —NR21R22, —NR21C(O)R22, —OC(O)R21, alkyl, alkenyl, alkynyl, aryl, heteroaryl, or heterocyclyl, each of which is independently substituted or -unsubstituted with a hydroxyl group, sulfhydryl group, halogen, amino group, nitro group, nitroso group, cyano group, azido group, sulfoxide group, sulfone group, sulfonamide group, carboxyl group, carboxaldehyde group, imine group, alkyl group, cycloalkyl group, halo-alkyl group, alkenyl group, halo-alkenyl group, alkynyl group, halo-alkynyl group, alkoxy group, aryl group, aryloxy group, aralkyl group, arylalkoxy group, heterocyclyl group, acyl group, acyloxy group, carbamate group, amide group, ureido group, epoxy group, or an ester group; or hydrogen or halogen;
R16 is hydrogen;
R17 is phenyl substituted or -unsubstituted with a hydroxyl group, sulfhydryl group, halogen, amino group, nitro group, nitroso group, cyano group, azido group, sulfoxide group, sulfone group, sulfonamide group, carboxyl group, carboxaldehyde group, imine group, alkyl group, cycloalkyl group, halo-alkyl group, alkenyl group, halo-alkenyl group, alkynyl group, halo-alkynyl group, alkoxy group, aryl group, aryloxy group, aralkyl group, arylalkoxy group, heterocyclyl group, acyl group, acyloxy group, carbamate group, amide group, ureido group, epoxy group, or an ester group;
each R19 and R20 is C(O)R23, —C(O)OR23, —C(O)NR23R24, —OR23, —SR23, —NR23R24, —NR23C(O)R24, —OC(O)R23, alkyl, alkenyl, alkynyl, aryl, heteroaryl, or heterocyclyl, each of which is independently substituted or unsubstituted with a hydroxyl group, sulfhydryl group, halogen, amino group, nitro group, nitroso group, cyano group, azido group, sulfoxide group, sulfone group, sulfonamide group, carboxyl group, carboxaldehyde group, imine group, alkyl group, halo-alkyl group, alkenyl group, halo-alkenyl group, alkynyl group, halo-alkynyl group, alkoxy group, aryl group, aryloxy group, aralkyl group, arylalkoxy group, heterocyclyl group, acyl group, acyloxy group, carbamate group, amide group, ureido group, epoxy group, or an ester group; or hydrogen or halogen; and
each R21, R22, R23, and R24 is independently alkyl, alkenyl, alkynyl, aryl, heteroaryl, or heterocyclyl, each of which is independently substituted or -unsubstituted with a hydroxyl group, sulfhydryl group, halogen, amino group, nitro group, nitroso group, cyano group, azido group, sulfoxide group, sulfone group, sulfonamide group, carboxyl group, carboxaldehyde group, imine group, alkyl group, halo-alkyl group, alkenyl group, halo-alkenyl group, alkynyl group, halo-alkynyl group, alkoxy group, aryl group, aryloxy group, aralkyl group, arylalkoxy group, heterocyclyl group, acyl group, acyloxy group, carbamate group, amide group, ureido group, epoxy group, or an ester group; or hydrogen;or a pharmaceutically-acceptable salt thereof.

US Pat. No. 10,138,208

PYRAZOLE DERIVATIVES AS INHIBITORS OF STAT3

Mayo Foundation for Medic...

1. A compound selected from:
or a pharmaceutically acceptable salt thereof.

US Pat. No. 10,138,200

PROCESS FOR PREPARING POLYOLS

Pivert S.A.S., Venette (...

1. A process for preparing polyols from a composition A, said composition A comprising one or more compounds of formula (I)
wherein
R1, R2, R3, R4, R5, R6 and R7 are, independently of one another, and for R3 and R7 independently for each of the n units, selected from the group consisting of H, —OR15, C1-C10 alkyl which is unsubstituted or substituted with one or more —OR15 groups, C6-C12 aryl which is unsubstituted or substituted with one or more —OR15 groups, or C3-C10 cycloalkyl which is unsubstituted or substituted with one or more —OR15 groups, and a group of formula (Ia)

R15 represents H or C1-C10 alkyl which is unsubstituted or substituted with one or more —OH groups;
a, b, x and y are independently of one another, independently for each group of formula (Ia), independently for each [(CH2)a—C?C—(CH2)b]r unit and independently for each [(CH2)x—C?C—(CH2)y]p unit, an integer between 0 and 20
r is an integer between 1 and 10
p is an integer between 1 and 10
n is an integer between 1 and 7;
said process comprising a step a) of placing together, with stirring and under an atmosphere of hydrogen and of carbon monoxide:
at least one precatalyst which is a complex comprising a transition metal chosen from column 9 of the periodic table,
a tertiary amine, or a non-quaternary ammonium salt thereof, of formula NR8R9R10 wherein R8, R9 and R10 represent, independently of one another, a C1-C10 alkyl, a C6-C12 aryl or a C3-C10 cycloalkyl, or R8 and R9 form, together with the nitrogen atom to which they are attached, a heterocycle comprising four, five or six ring members,
said composition A comprising said compound of formula (I).

US Pat. No. 10,138,195

ORGANIC COMPOUNDS

Givaudan, S.A., Vernier ...

1. A compound represented by formula I
wherein
R1 is —(CHR4)m—(CHR5)n—(CHR6)o—CHO, with R4, R5, R6 being independently selected from H or Me, and with m, n, o being independently selected from 0 and 1;
R2 is Me; and
R3 is a C3-C6 branched, linear or cyclic alk-2-enyl residue.

US Pat. No. 10,138,191

1-HALO-6,9-PENTADECADIENE AND METHOD FOR PRODUCING (7Z,10Z)-7,10-HEXADECADIENAL

SHIN-ETSU CHEMICAL CO., L...

1. A method for producing (7Z,10Z)-7,10-hexadecadienal of Formula (9):comprising steps of:subjecting a Grignard reagent formed from a (6Z,9Z)-1-halo-6,9-pentadecadiene of Formula (1-6Z9Z):

wherein X stands for a halogen atom,
 to a nucleophilic substitution reaction with an orthoformate ester of Formula (2):

wherein R may be same with or different from each other and stands for an alkyl group having from 1 to 6 carbon atoms,
 to obtain a (7Z,10Z)-1,1-dialkoxy-7,10-hexadecadiene of Formula (3):

wherein R may be same with or different from each other and stands for an alkyl group having from 1 to 6 carbon atoms; and
hydrolyzing the (7Z,10Z)-1,1-dialkoxy-7,10-hexadecadiene (3) to obtain the (7Z,10Z)-7,10-hexadecadienal (9).

US Pat. No. 10,138,188

CATALYST FOR PRODUCING METHANOL PRECURSOR, METHANOL PRECURSOR PRODUCED USING THE CATALYST AND METHANOL PRODUCED USING THE METHANOL PRECURSOR

Korea Institute of Scienc...

1. A method for producing a methanol precursor, comprising (A) mixing a catalyst with an acid solution and supplying methane gas at a pressure of 10 to 50 bar to the mixture, the catalyst being represented by Formula 1:
wherein X is selected from the group consisting of Cl, Br, I and F, and R and R? are the same as or different from each other and are each independently selected from the group consisting of a hydrogen atom, substituted or unsubstituted C1-C7 alkyl groups, substituted or unsubstituted C8-C30 alkyl groups, substituted or unsubstituted C6-C40 aryl groups, and substituted or unsubstituted C2-C30 heteroaryl groups; or
Formula 2:

wherein X? is selected from the group consisting of Cl, Br, I and F, and R? is selected from the group consisting of a hydrogen atom, substituted or unsubstituted C1-C7 alkyl groups, substituted or unsubstituted C8-C30 alkyl groups, substituted or unsubstituted C6-C40 aryl groups, and substituted or unsubstituted C2-C30 heteroaryl groups.

US Pat. No. 10,138,183

PROCESS AND COMPOSITION FOR INHIBITING THE POLYMERIZATION OF CYCLOPENTADIENE COMPOUNDS

Evonik Degussa GmbH, Ess...

1. A composition (AB), comprising:a cyclopentadiene compound (B), and
a compound (A) of structure (I):

wherein
R1 and R2 are each tert-butyl; and
R3 is —CN, —O—R10, or —R12, where R10 is methyl, ethyl, n-propyl, iso-propyl, n-butyl, n-pentyl, or n-hexyl and R12 is 2-furyl, 3-furyl, or phenyl.

US Pat. No. 10,138,182

OXYGEN TRANSFER AGENTS FOR THE OXIDATIVE DEHYDROGENATION OF HYDROCARBONS AND SYSTEMS AND PROCESSES USING THE SAME

Bio2Electric, LLC, Monmo...

1. An oxygen transfer agent for the oxidative dehydrogenation of unsaturated hydrocarbons, said oxygen transfer agent comprising:a mixed oxide which is Mg6MnO8, and
at least two promoters which include W and P.

US Pat. No. 10,138,178

OXIDATIVE CRACKING OF ALKANES WITH FLUIDIZED VANADIUM CATALYST

King Fahd University of P...

1. A method for the oxidative cracking of an alkane to produce one or more olefins comprising:flowing the alkane through a fluidized bed reactor comprising a catalyst chamber loaded with a catalyst at a temperature in the range of 450-700° C. to form the one or more olefins and a reduced catalyst, wherein the alkane is a C2-C8, straight chain linear alkane,
wherein the catalyst comprises:
a support material comprising alumina modified by cerium; and
a catalytic material comprising one or more vanadium oxides disposed on the support material;
wherein the catalyst comprises 1-15% of the one or more selected from the group consisting of V2O5, VO2, and V2O3 by weight relative to the total weight of the catalyst, and
wherein the catalyst comprises 0.05-1.0% of cerium by weight relative to the total weight of the catalyst.

US Pat. No. 10,138,174

MANUFACTURE OF ETHYLENE FROM ETHANOL

John E. Stauffer

1. A process for the synthesis of ethylene from substantially pure ethanol including the steps of carrying out two simultaneous reactions in the presence of a solid catalyst wherein the first reaction is(a) C2H5OH +HCl?C2H5Cl +H2O, and the second reaction is
(b) C2H5Cl?C2H4+HCl
(c) wherein the HCl produced in reaction (b) is consumed in reaction (a) and the HCl for reaction (a) is supplied by reaction (b),
and wherein said two simultaneous reactions take place in a reaction vessel containing the solid catalyst of an intimate admixture of activated carbon and silica alumina.

US Pat. No. 10,138,169

HIGHLY POROUS CERAMIC MATERIAL AND METHOD OF USING AND FORMING SAME

The Regents of the Univer...

1. A method of forming a porous ceramic material, the method comprising the steps of:providing polymer sacrificial substrate particles;
depositing ceramic material onto the polymer sacrificial substrate particles using atomic layer deposition techniques to form a continuous layer of the ceramic material overlying the polymer sacrificial substrate particles; and
exposing the polymer sacrificial substrate particles and the ceramic material to an environment to cause the polymer sacrificial substrate particles to disintegrate and thereby form a porous ceramic material,
wherein a surface area per weight of the ceramic material is greater after the step of exposing than the surface area per weight of the ceramic material prior to the step of exposing.

US Pat. No. 10,138,166

ALUMINA SINTERED BODY AND BASE SUBSTRATE FOR OPTICAL DEVICE

NGK Insulators, Ltd., Na...

1. An alumina sintered body having a surface with a degree of c-plane orientation of 90% or more as determined by Lotgering's method from an X-ray diffraction profile obtained by X-ray irradiation in a range of 2?=20° to 70°,having no pores when any cross-sectional surface is polished by ion milling and is examined under a scanning electron microscope at a magnification of 5,000 times,
having a total mass fraction of impurity elements other than Mg and C of 100 ppm or less, and
wherein the alumina sintered body contains 30 to 70 ppm by mass fraction of C.

US Pat. No. 10,138,152

LOCK RING MOUNTING ARRANGEMENT FOR BLOW HEADS

Emhart Glass S.A., Cham ...

1. A blow head mounting arrangement for use with a blow head arm onto which multiple blow heads will be installed, the blow head mounting arrangement comprising:a blow head having a first engagement member located on a top of the blow head, wherein the first engagement member comprises:
a blow head mounting element connected to the blow head by a blow head neck;
a second engagement member located under the blow head arm, wherein the second engagement member comprises:
a lock ring member having a hollow interior portion with a pair of opposed engagement flanges located at a bottom of the lock ring member and defining an opening therebetween;
wherein the first and second engagement members are respectively arranged and configured to allow the first engagement member of the blow head to be raised and admitted to or lowered and withdrawn from the second engagement member when the blow head is in a first rotational position with respect to the second engagement member; and
wherein the first and second engagement members are respectively arranged and configured to allow the first engagement member of the blow head to be locked in the second engagement member when the blow head is rotated from the first rotational position with respect to the second engagement member to a second rotational position with respect to the second engagement member while the first engagement member of the blow head is admitted to the second engagement member;
a spring-loaded retaining mechanism for removably maintaining the blow head in the second rotational position with respect to the second engagement member, wherein the retaining mechanism comprises:
a first retaining mechanism located in the blow head mounting element; and
a second retaining mechanism located in the lock ring member;
wherein the first retaining mechanism located in the blow head mounting element comprises:
a pair of locking flanges extending from opposite sides of the blow head mounting element; and
wherein the second retaining mechanism located in the lock ring member comprises:
a pair of detent recesses respectively located in the opposed engagement flanges in the lock ring member, the detent recesses being configured to engage the locking flanges when the blow head is in the second rotational position with respect to the second engagement member;
wherein the lock ring member comprises an upper lock ring member and a lower lock ring member defining the hollow interior portion therebetween, the opposed engagement flanges being located at a bottom of the lower lock ring member, and wherein the retaining mechanism additionally comprises:
a spring member biasing the upper lock ring member toward the opposed engagement flanges in the lower lock ring member; and
wherein the upper lock ring member includes a skirt bounding a receiving region of the hollow interior portion, the receiving region arranged such that the locking flanges of the blow head mounting element and the opposed engagement flanges located at the bottom of the lower lock ring member are received within the receiving region bounded by the upper lock ring member in the second rotational position, the opposed engagement flanges extending through notches formed in the skirt of the upper lock ring member to reach the receiving region.

US Pat. No. 10,138,150

METHODS AND SYSTEMS FOR TREATING VINASSE

WATER SOLUTIONS, INC., S...

1. A method for treating vinasse, the method comprising:obtaining a quantity of vinasse;
reacting the vinasse with persulfate to form an oxidized mixture;
reacting the oxidized mixture with peroxide to form a peroxide-treated mixture;
adjusting the pH of the peroxide-treated mixture to a pH value in the range from pH 6 to pH 7, to form a pH-adjusted mixture;
reacting the pH-adjusted mixture with an inorganic coagulant and a low molecular weight cationic polymer to form solid particles; and
removing the solid particles to yield a liquid fraction.

US Pat. No. 10,138,144

APPARATUS AND METHOD FOR THE SEAWATER PRE-TREATMENT FOR DESALINATING SEAWATER INTO FRESH WATER

1. A seawater pre-treatment method comprising:installing a plurality of water collection pipes at a predetermined depth from sea level, the water collection pipes being supported by a support part, each water collection pipe having a plurality of openings formed on a side portion thereof and being in fluid communication with a water collection tank which is configured to accommodate pre-treated water;
installing a plurality of filtration filters spacedly arranged from each other in a longitudinal direction of each of the plurality of water collection pipes, each filtration filter surrounding a water collection pipe, among the plurality of water collection pipes, the filter being in the form of a hollow cylinder, wherein each filtration filter comprises meshes, a size of the meshes being configured such that the filter does not allow impurities contained in seawater to pass through, but allows salt to pass through, and each filtration filter has a vertical side portion parallel to a vertical side portion of the water collection pipe, wherein the vertical side portion of the filtration filter directly contacts the seawater to be pre-treated;
sucking the pre-treated water from an inner part of the water collection tank using a water conveying pump in such a way that the seawater passes through the filtration filter by a difference in pressure between an inside and an outside of the filtration filter caused by the sucking the pre-treated water and flows into the water collection pipe and the water collection tank; and
removing the impurities attached to the outside of the filtration filters by raising or lowering a plurality of strainers along the filtration filters,
wherein each strainer of the strainers is in the form of a ring and is inserted into the outside of the each filtration filter, a connecting plate connects the strainers with each other, and a water pump is installed into the connecting plate to raise or lower the connecting plate by a driving force by jetting the seawater.

US Pat. No. 10,138,142

WASTEWATER TREATMENT SYSTEM AND METHOD

Eco Water Technologies Co...

1. A system for treating sanitary and municipal wastewater, comprising:a Richter-type separator including a first outlet port discharging a lighter-than-water solids stream, a second outlet port discharging a heavier-than-water solids stream, and a third outlet port discharging a partially-clarified water stream; and
the lighter-than-water solids stream and the heavier-than-water solids stream are combined together forming a combined stream.

US Pat. No. 10,138,141

METHOD AND DEVICE FOR BLOWING OFF GASEOUS CONTAMINANTS FROM CRUDE WATER IN THE PRODUCTION OF DRINKING WATER

MICRODROP AQUA APS, Faer...

1. A method for blowing off a gaseous contaminant from crude water in the production of drinking water, said method comprising the step ofintroducing the water containing the gaseous contaminant into the top of a shielded aerator, said aerator comprising means for forming drops at the initiation of the treatment process, and division means for causing division of said drops by contact therewith, said division means being arranged below the means for forming drops, wherein the division means for causing division of the drops comprise a plurality of tubular elements in the form of pipes having reticulate pipe walls, said tubular elements being placed in horizontal layers of plural parallel tubular elements stacked in such a way that the longitudinal axes of the tubular elements in one layer are angularly displaced in relation to the longitudinal axes of the tubular elements in the one or more adjacent layers;
letting the water pass through said aerator to the bottom thereof by the force of gravity; and
wherein air is introduced to the bottom of the aerator and is drawn to the top of the aerator and discharged together with blown-off contaminant by a pump at the top of the aerator,
and wherein bubble formation and horizontal redistribution of the water is brought about as the water passes through one or more perforated sheets, which are intercalated between a number of said horizontal layers of tubular elements.

US Pat. No. 10,138,138

SYSTEM AND METHOD OF GREYWATER RECOVERY AND REUSE

1. A control system for a greywater recovery and reuse system, said greywater recover and reuse system having a tank, a filter upstream of said tank, a return line from said tank to at least one toilet, a fresh water connection and a waste water outlet, said control system comprising:a. a controller;
b. a water level sensor for said tank connected to said controller;
c. a source of power for said controller;
d. at least one solenoid actuable by said controller;
e. a pump operatively connected to said controller;
f. a pressure sensor within said return line for sensing a need for greywater upon said at least one toilet being flushed, said pressure sensor being operatively connected to said pump; and
g. a timing means;
wherein said controller is programmed to:
i. calculate an average volume of water used for one toilet flush;
ii. use said calculated average volume of water to determine a minimum water level to be maintained in said tank; and
iii. add fresh water to said tank to raise said water level to said minimum water level if said water level in said tank drops below said minimum water level;
whereby said controller maintains sufficient water in said tank for one toilet flush.

US Pat. No. 10,138,137

WASHOUT PAN FOR THIXOTROPIC MATERIALS

1. A method for separating a thixotropic, cement-containing, settled slurry body from a washout pan of less than 300 but more than 100 gallons capacity, the method comprising:providing the washout pan comprising
a generally rectangular box shape, rotomolded of polymer to form an open top box with peripheral walls of from 9 to 15 inches high as measured from a top reinforcing rim plate to a bottom most surface, the washout pan having an overall wall thickness of from 0.15 to 0.75 inches;
the peripheral walls comprising a lifting section opposed to a bottom section and a right section opposed to a left section, where the lifting section comprises lifting flanges arranged symmetrically about a midline between the lifting section and the bottom section;
a first level support floor intersecting the peripheral walls at a substantial elevation from a set of second level support floors so that the settled slurry body covers both the first level support floor and the set of second level support floors, where nine openings are defined in the first level support floor, four corner openings being defined adjacent to corners of the peripheral walls, right and left openings defined respectively adjacent to the right and left sections, a first mass cavity opening being defined adjacent to the lifting section, a second mass cavity opening being defined in a center of the first level support floor, and a third mass cavity opening being defined adjacent to the bottom section, where the first, second and third mass cavity openings are symmetrically arranged about the midline and all the openings are spaced substantially away from each other so that the settled slurry body comprises a structurally connected mass during its separation from the washout pan; and
second level support walls extending down from all the openings to be sealed at second level support floors equidistant and parallel to the first level support floor;
setting the washout pan horizontally to be filled with the slurry body; and
lifting the washout pan to a vertical position by way of the lifting flanges, resulting in deformation of highest elevation second level support walls of containers formed about the first, second and third mass cavity openings and detachment of the slurry body from the washout pan.

US Pat. No. 10,138,136

LIQUID FILTER DEVICE

New Aqua, LLC, Avon, IN ...

1. A liquid filter device comprising:a hub including a base having a socket, and a plurality of members positioned to extend upwardly from an outer periphery of the base and form a plurality of respective slots therebetween;
a plurality of laterals having a first end and a second end, the first end of each of the laterals positioned in the respective slots and including a pair of opposing vertical slots slidably engaging the members of the hub to form a structure positionable in a tank, each of the laterals extending radially in different directions away from the hub such that the second ends are spaced away from the hub;
a conduit pilot mechanism engaged with the socket of the hub, and including a circumferential skirt engaged with upper surfaces of the first ends of the laterals to maintain the opposing vertical slots on the first ends of the laterals slidably engaged with the members of the hub, and a central aperture at a top of the conduit pilot mechanism for receiving a conduit; and
each of the laterals formed to include an internal cavity, the internal cavity formed with a first volume at the first end and a second volume between the first end and the second end, the second volume being larger than the first volume.

US Pat. No. 10,138,134

METHOD FOR FABRICATION OF SUPERLATTICES AND APERIODIC LAYERED STRUCTURES USING SOLUTION DEPOSITION

UChicago Argonne, LLC, C...

1. A method for forming inorganic structures, comprising:(a) transferring nanocrystals to a polar protic solvent using a chalcogenide precursor to produce a negatively-charged nanocrystal surface comprising negatively-charged chalcogen atoms bonded to metal atoms of the nanocrystal located on the nanocrystal surface;
(b) removing excess anions of the chalcogenide precursor;
(c) introducing a divalent metal salt to bind divalent metal cations to the negatively-charged chalcogen atoms bonded to the nanocrystal surface such that a metal chalcogenide monolayer is deposited on the nanocrystal surface; and
(d) removing excess divalent metal cations of the divalent metal salt.

US Pat. No. 10,138,133

PROCESS FOR PRODUCING AMMONIUM SULFATE CRYSTALS

CAP III B.V., Urmond (NL...

1. A continuous process for producing ammonium sulfate crystals, wherein the process comprises:i) feeding a solution of ammonium sulfate comprising impurities to a heat-integrated series of crystallization sections;
ii) crystallizing ammonium sulfate crystals from the solution of ammonium sulfate;
iii) purging a fraction of the solution of ammonium sulfate from each of the crystallization sections; and
iv) discharging ammonium sulfate crystals from each of the crystallization sections, wherein
the ammonium sulfate crystals discharged from each of the crystallization sections are not charged to another crystallization section, and wherein
the process further comprises:
heat-integrating the crystallization sections by steam, and
purging a fraction of the solution of ammonium sulfate from each crystallization section in the series to the next crystallization unit in the series, as defined by descending temperature of steam supply, with the exception that the fraction of the solution of ammonium sulfate purged from the final crystallization section in the series is discharged from the series.

US Pat. No. 10,138,132

SYNTHESIS OF MTW FRAMEWORK TYPE MOLECULAR SIEVES

Chevron U.S.A. Inc., San...

1. A method of synthesizing a molecular sieve of MTW framework type, the method comprising:(a) preparing a reaction mixture comprising:
(1) a source of silicon oxide;
(2) a source of an oxide of a trivalent element (X);
(3) a source of Group 1 or 2 metal (M);
(4) a structure directing agent (Q) comprising 1,1-diethyl-4-methylpiperidinium cations;
(5) hydroxide ions; and
(6) water; and
(b) subjecting the reaction mixture to crystallization condition sufficient to form crystals of the molecular sieve.

US Pat. No. 10,138,130

ULTRA DENSE AND ULTRA LOW POWER MICROHOTPLATES USING SILICA AEROGEL AND METHOD OF MAKING THE SAME

The University of Louisia...

1. A method of making silica aerogel thin and thick films comprising:a. mixing TEOS, ethanol, water and HCl with the molar ratio of approximately 1:4:2:4.3×10?4, respectively to form a first solution;
b. stirring said first solution;
c. adding 0.64 ml of 0.066 M NH4OH to create a second solution;
d. stirring said second solution to create a sol-gel mixture;
e. aspirating the sol-gel mixture with an aspirator at approximately 15% of gelation time;
f. spraying said sol-gel mixture into a column of ethanol to create an impregnated ethanol mixture;
g. aging said impregnated ethanol mixture at room temperature;
h. ultrasounding said impregnated ethanol mixture;
i. filtering said impregnated ethanol mixture resulting in a filtered impregnated ethanol mixture; and
j. spin coating said filtered impregnated ethanol mixture onto a wafer creating an aerogel layer.

US Pat. No. 10,138,125

ELECTRICALLY CONDUCTIVE THIN FILMS

SAMSUNG ELECTRONICS CO., ...

1. An electrically conductive thin film, comprising a plurality of nanosheets, wherein the plurality of nanosheets comprises:a compound represented by Chemical Formula 1 or Chemical Formula 2 and having a layered crystal structure
M1Te2  Chemical Formula 1
wherein M1 is zirconium, hafnium, vanadium, tantalum, or niobium; or
M2Se2  Chemical Formula 2
wherein M2 is vanadium or tantalum,
wherein the electrically conductive thin film has a thickness of less than or equal to about 20 nanometers,
wherein the electrically conductive thin film has a transmittance of greater than or equal to about 80% for light having a wavelength of about 550 nanometers, and
wherein the film has an electrical conductivity of greater than or equal to about 2200 Siemens per centimeter.

US Pat. No. 10,138,116

METHOD FOR INTEGRATING COMPLEMENTARY METAL-OXIDE-SEMICONDUCTOR (CMOS) DEVICES WITH MICROELECTROMECHANICAL SYSTEMS (MEMS) DEVICES USING A FLAT SURFACE ABOVE A SACRIFICIAL LAYER

Taiwan Semiconductor Manu...

1. An integrated circuit (IC) comprising:a semiconductor substrate;
a back-end-of-line (BEOL) interconnect structure over the semiconductor substrate, wherein the BEOL interconnect structure comprises wiring layers stacked in a dielectric region, and wherein an upper surface of the BEOL interconnect structure is planar or substantially planar; and
a microelectromechanical systems (MEMS) structure overlying and directly contacting the upper surface of the BEOL interconnect structure, wherein the MEMS structure comprises an electrode layer directly over a cavity, and further comprises a MEMS layer different in material than the electrode layer;
wherein the cavity is under the upper surface of the BEOL interconnect structure, between the MEMS structure and the BEOL interconnect structure, and wherein the dielectric region and/or the MEMS layer separate the electrode layer from the cavity.

US Pat. No. 10,138,113

ELECTRONIC VAPORISER SYSTEM

BEYOND TWENTY LTD., Lond...

1. An electronic cigarette vaporiser system that includes an electronic vaporiser, and the vaporiser has a square or rectangular cross-section and includes a long PCB inserted lengthwise into the vaporiser, in which the electronic vaporiser system includes:(i) a user-replaceable, e-liquid cartridge, which is not user-refillable and includes no heating element;
(ii) an e-liquid reservoir that is separate from the user-replaceable e-liquid cartridge;
(iii) an electric or electronic pump that is configured to withdraw e-liquid from the user-replaceable e-liquid cartridge and pump pressurised e-liquid to the e-liquid reservoir and
(iv) a heating element that is not in the user-replaceable e-liquid cartridge but is instead in, or in e-liquid communication with, the e-liquid reservoir.

US Pat. No. 10,138,110

ATTACHMENT AND SYSTEM FOR MIXING AND DISPENSING A CHEMICAL AND DILUENT

1. A system for mixing and dispensing cleaning solution, the system comprising:a body with a first flow passage extending between a diluent inlet and an outlet, and a second flow passage extending between a concentrate inlet and the first flow passage; and
a container for cleaning concentrate, the container including a container valve,
wherein moving the body axially toward the container to seat the body on the container opens the container valve for a flow of concentrate from the container to the first flow passage via the second flow passage,
wherein moving the body axially away from the container to unseat the body from the container closes the container valve to the flow of concentrate, and
wherein the container includes an oblong neck configured to engage the body to secure the container to the body.

US Pat. No. 10,138,107

FROZEN BEVERAGE DISPENSING MACHINES WITH MULTI-FLAVOR VALVES

Cornelius, Inc., Osseo, ...

1. A beverage machine comprising:a valve that receives a base fluid and dispenses a mixed beverage comprising the base fluid and an additive fluid, the valve having a perimetral surface that defines a bore through which the base fluid flows and a channel that surrounds the bore and through which the additive fluid flows to a plurality of ports defined in the perimetral surface through which the additive fluid is radially injected into the bore to thereby mix with the base fluid; and
an injector coupled to the valve and configured to inject the additive fluid into the channel such that the additive fluid flows through the channel and the plurality of ports to thereby mix into the base fluid to form the mixed beverage, wherein the injector has:
an injector axis along which the injector extends;
a surface centered about the injector axis and configured to radially inwardly direct the additive fluid toward the injector axis along which the additive fluid is injected into the channel; and
a manifold configured to receive a plurality of fluid components and dispense the plurality of fluid components, wherein the surface radially inwardly directs the plurality of fluid components toward the injector axis such that the plurality of fluid components mix and form the additive fluid.

US Pat. No. 10,138,106

APPARATUS AND METHOD FOR PRODUCING PLASTIC BOTTLES

KRONES AG, Neutraubling ...

1. An apparatus for producing plastic bottles, comprising at least three machines, the at least three machines comprising a blow molding machine, a labeling machine and at least one further treatment machine, wherein at least two transfer starwheels being arranged between the blow molding machine and the labeling machine with at least one of the transfer starwheels oriented to change pitch of the bottles upon engagement of the at least one of the transfer starwheels with the bottles, the transfer starwheels arranged in a sequence forming a meandering path leading from the blow molding machine to the labeling machine, the blow molding machine and the labeling machine being spaced from one another, and bloc-synchronized with one another, by the transfer starwheels and without buffers positioned between the blow molding machine and the labeling machine, the transfer starwheels forming functional separation points facilitating decoupling between the machines both during operation and for maintenance purposes, wherein decoupling is achieved by selectively deactivating a drive of one or more of the transfer starwheels, wherein the machines and the transfer starwheels are arranged in a way that a continuous neck handling plane is formed for different bottle sizes, and a cover enclosing one or more additional transfer starwheels, the cover providing an air lock that prevents contamination of air to which filler is exposed with glue-containing air from the labeling machine.

US Pat. No. 10,138,104

BELOW THE BEAD FOIL CUTTER

1. A device for cutting the foil on a bottle, comprising:a substantially U-shaped body, comprising:
first and second opposing arms, when in an upright state, the arms together defining a body top side and a body exterior side, each of the arms defining a bottom side;
a first neck protruding from the top side on the first arm and a second neck protruding from the top side on the second arm, wherein each of the necks has a circular sector shaped retaining lip that defines a neck interior space, the circular sector shaped retaining lips together forming a substantial portion of a circular shape; and
at least one cutting element on each of the bottom sides, wherein when a top of the bottle is received in both of the neck interior spaces so as to engage both of the retaining lips, both of the at least one cutting elements are configured to cut the foil of the bottle.

US Pat. No. 10,138,101

METHOD IN FORKLIFT TRUCK FOR DETERMINING A LOAD POSITION IN A LOAD RACK

1. A method in a forklift truck, for determining a load position in a load rack, the forklift truck including a camera movable with a load carrier, the method comprising the steps of:determining a reference position related to the camera of a first land mark located on a first height of the load rack based on the position of the first landmark in a first image captured by the camera;
altering a height of the load carrier to alter a position of the camera;
determining a second position related to the camera of a second land mark located on a second height of the load rack based on the position of the second landmark in a second image captured by the camera at a predetermined height;
determining the load position on the second height based on a comparison between the reference position and the second position; and
adjusting a position of the load carrier based upon the determined load position.

US Pat. No. 10,138,099

POWER WINCH HORIZONTAL-PUSH WINCH

Comeup Industries Inc., ...

1. A power winch horizontal-push winch, characterized in that the power winch supplies power from a power source and transmits the power to a cable wheel after a deceleration is made by a reducer, so that the cable wheel may be rotated in a forward or reverse direction to release or wind a cable wound around the cable wheel; a casing of the reducer has a binding groove formed thereon and an inner thread formed on an inner wall of the casing; the reducer includes an outer ring body having an insert hole formed on an outer surface of the reducer; the power winch includes a clutch, and positioning of a binding groove formed on the casing of the reducer may or may not be applied to the insert slot of the outer ring body, so that the power may or may not be transmitted from the reducer to the cable wheel; the clutch comprises an inner seat, a control plate, a wedge, an operating handle and a clutch lever, wherein the inner seat includes a cylindrical lower insert tube, a cylindrical upper insert tube, and a baffle with the middle in an outwardly extended angular form, and an outer wall of the lower insert tube has an outer thread, and the junction of the lower insert tube and the baffle has an O-ring, and the bottom end of the inner seat has an opening and a chamber formed deeply inside the opening, and the top end of the upper insert tube is passed to the outside to form an angular slot, and an upper sink socket is formed around the angular slot, and an upper ring groove and a lower ring groove are concavely formed on the outer surface of the inner seat, and the upper ring groove is provided for installing an O-ring; the control plate is in form of a round plate having a round bump at the bottom of the round plate, a circular penetrating hole penetrating through the middle of the round plate, and a plurality of corresponding elevating ribs is formed on the top side of the round plate and disposed on both sides of the penetrating hole; the wedge has a disc-shaped base, an angular slot penetrating the middle of the wedge, and a plurality of adjusting members in an arc shape and disposed at the bottom of the base, and the bottom surface of each adjusting member is divided into an oblique slope and a press-in slot, and the oblique slope descends gradually from the bottom surface of the base and passes through a boundary edge to enter into the press-in slot after reaching the bottom, and a spacing is formed between two adjusting members, and the spacing disposed at the edge of the base is the narrowest, so as to form a through hole, and the through hole has a width not smaller than the width of the elevating rib; the operating handle comprises a socket portion and a handle portion, and the bottom surface of the socket portion is inwardly hollow, and the hollow top forms a first accommodation space sufficient to accommodate the wedge, and the hollow middle section has a plurality of even accommodating slots, each accommodating slot is configured to be corresponsive to the center and arranged in a surrounding form, and the accommodating slot has a width sufficient to accommodate the elevating rib, and a hollow bottom of the accommodating slot is a second accommodation space, and the second accommodation space has a size sufficient to accommodate the control plate and the upper insert tube of the inner seat, and a plurality of screw holes are formed on a side wall proximate to the bottom for screwing and installing a positioning bolt; the handle portion is extended laterally from the socket portion to the outside to form a handle object provided for being held by a user's hand; the clutch lever has an insert member which can be accommodated in the chamber of the inner seat, and selectively controlled to pass downwardly out from the opening of the inner seat and insert into the insert slot of the outer ring body; the insert member has a polygonal prism coupled thereto, and the polygonal prism of the insert member has a shape matched with an angular slot of the inner seat and an angular slot of the wedge, and an outer surface of the polygonal prism of the insert member has a ring groove formed at a position proximate to the top, and the polygonal prism of the insert member is provided for sheathing and installing an elastic member, and the ring groove is provided for clamping and positioning a latch ring; during assembling, the elastic member of the clutch lever is sheathed and mounted on the polygonal prism, and the polygonal prism is passed from bottom to top and out from the angular slot of the inner seat, such that the insert member of the clutch lever enters into the chamber of the inner seat; and then the control plate is installed next to the top side of the top side of the upper insert tube of the inner seat, and the round bump at the bottom of the control plate enters and stays in the upper sink socket at the top side of the upper insert tube, and the polygonal prism of the clutch lever is passed out from the penetrating hole of the control plate; and then the wedge is installed next to the top side of the control plate, such that the two through holes of the wedge are disposed across an elevating rib, and the polygonal prism of the clutch lever is passed from bottom to top and out from the angular slot of the wedge, and then the latch ring is clamped in the groove of the polygonal prism; and then the outer thread of the lower insert tube of the inner seat is screwed and engaged with the inner thread of the binding groove of the casing of the reducer to abut the O-ring at the junction of the lower insert tube and the baffle, while the periphery of the bottom of the baffle abuts the sink socket at the outer periphery of the top side of the binding groove for positioning; and then the socket portion of the operating handle is sheathed on the wedge and the clutch lever, and the wedge and the top end of the clutch lever enter into the first accommodation space of the socket portion, and the elevating rib of the control plate enter into the plurality of accommodating slots for positioning, and the plate body of the control plate and the socket of the inner seat enter into the second accommodation space, while the inner wall of the socket portion abuts the O-ring sheathed on the upper ring groove of the upper socket, and the screw hole of the socket portion is aligned precisely with the lower ring groove of the upper socket, and then the positioning bolt is screwed into each screw hole, so that the rear end of the positioning bolt passes out from the screw hole and enters into the lower ring groove.

US Pat. No. 10,138,096

AUTOMATIC ERECTION OF A CRANE

1. A process for automatic movement of a boom system of a crane with at least two boom elements comprising a fly jib and a main boom, wherein the process includes the following steps:while controlling a drive of the main boom to move the main boom, measuring at least one control parameter; and
during the movement of the main boom, automatically actuating a drive of the fly jib depending on the control parameter measured,
wherein the automatic actuation of the drive of the fly jib during the movement of the main boom maintains the at least one measured control parameter within specific intervals or within one specific interval at least temporarily, and wherein the at least one measured control parameter includes one or more of a relative angle between the boom elements and a force carried by a guy of the fly jib.

US Pat. No. 10,138,093

PASSENGER CONVEYOR STEP FLOW ADJUSTING APPARATUS

MITSUBISHI ELECTRIC CORPO...

1. A passenger conveyor step flow adjusting apparatus in which:forward path driving rails are installed in a longitudinal direction of a main frame on an upper portion side inside said main frame so as to be supported on said main frame by means of rail supporting members so as to be spaced apart in a width direction of said main frame;
return path driving rails are installed in said longitudinal direction of said main frame on a lower portion side of each of said forward path driving rails that are spaced apart in said width direction of said main frame so as to be supported on said main frame by means of said rail supporting members so as to be spaced apart in a width direction of said main frame; and
a plurality of steps that are linked endlessly move cyclically through said main frame such that driving rollers roll on said forward path driving rails and said return path driving rails that are spaced apart in said width direction of said main frame,
wherein said passenger conveyor step flow adjusting apparatus comprises:
guiding pads that are disposed on two sides in a width direction of said steps, and that contact facing wall surfaces of said return path driving rails that are spaced apart in said width direction of said main frame, to suppress movement of said steps in said width direction; and
a return path driving rail position adjusting portion that adjusts a position of each of said return path driving rails that are spaced apart in said width direction of said main frame in said width direction relative to said rail supporting members,
wherein said return path driving rail position adjusting portion comprises:
a rail supporting block that is fixed to a lower surface of said return path driving rails;
a mounting plate that extends downward from said rail supporting block:
a position adjusting bolt that is fixed to said mounting plate; and
a pair of nuts that are screwed on an opposite side from said rail supporting member onto a shaft portion of said position adjusting bolt that passes through said rail supporting member, and that fix said mounting plate to said rail supporting member by fastening.

US Pat. No. 10,138,092

TRANSPORTATION ELEMENT FOR A PEOPLE CONVEYOR

OTIS ELEVATOR COMPANY, F...

1. A transportation element for a people conveyor, wherein the transportation element is configured to be moved in a conveying direction and comprises:an upper flange;
a lower flange;
an intermediate element extending between and connecting the lower flange and the upper flange; and
a tread, which is connected to, or formed integrally with, the upper flange;
wherein the intermediate element comprises a rectangular hollow web, the web extending basically perpendicularly to the planes spanned by the upper and lower flanges.

US Pat. No. 10,138,090

ELEVATOR CAR ROLLING SUPPRESSION DEVICE AND METHOD

FUJITEC CO., LTD., Hikon...

1. An elevator car rolling suppression device comprising:a drive unit attached to an elevator car provided to be elevatable within a shaft provided in a building, the drive unit being configured to press, against a guide rail, a guide unit provided to be movable along the guide rail extending in the vertical direction along the shaft, the guide unit being configured to restrict movement of the elevator car in the lateral direction orthogonal to the vertical direction;
a position detecting unit configured to detect a position of the elevator car in the vertical direction within the shaft;
a speed measuring unit configured to measure an elevation speed of the elevator car;
a storage unit configured to store in advance a plurality of elevation patterns in each of which at least one of the departure floor and the destination floor of the elevator car is different, and the elevation speed of the elevator car at a specific position in the vertical direction within the shaft is different, and further to store in advance the position of the elevator car in the vertical direction within the shaft and the acceleration in the lateral direction of the elevator car at the position of the elevator car for each of the plurality of elevation patterns in association with each other; and
a control unit configured to extract, based on the position of the elevator car detected by the position detecting unit and the elevation speed of the elevator car measured by the speed measuring unit, the elevation pattern from the storage unit, further extracts, based on the position of the elevator car detected by the position detecting unit and the extracted elevation pattern, the acceleration of the elevator car in the lateral direction stored in association with the stored position of the elevator car corresponding to the position of the elevator car detected by the position detecting unit from the storage unit, and controls the drive unit so as to adjust the pressing force of the guide unit against the guide rail to a pressing force that is derived based on the extracted acceleration in the lateral direction of the elevator car, in response to the detection of the position of the elevator car by the position detecting unit.

US Pat. No. 10,138,089

FLEXIBLE PRINTED CIRCUIT BOARD REEL DEVICE

YI CHEN CHEN, Taipei (TW...

1. A flexible printed circuit board real device, characterized in comprising a left housing, a right housing, a rotary sleeve, an upper spiral spring and a lower spiral spring, wherein the left housing and the right housing are caught with each other to form a housing, and the left housing and the right housing are respectively provided with a board outlet; an upper portion of the rotary sleeve is provided with an upper accommodating space and a lower portion of the rotary sleeve is provided with a lower accommodating space, and the upper spiral spring is disposed in the upper accommodating space and the lower spiral spring is disposed at the lower accommodating space; an upper portion of the housing is provided with an upper central shaft and an lower portion of the housing is provided with a lower central shaft, and the upper central shaft extends into the upper accommodating space of the rotary sleeve and catches the upper spiral spring and the lower central shaft extends into the lower accommodating space of the rotary sleeve and catches the lower spiral spring, whereby the rotary sleeve is rotatably disposed in the housing, and an outer surface of the rotary sleeve is provided with a protection sheet for catching the flexible printed circuit board.

US Pat. No. 10,138,088

IMAGE FORMING APPARATUS WITH A FINISHER TO APPLY A NOTE ONTO A PRINTED PAGE

KYOCERA DOCUMENT SOLUTION...

1. A finishing unit for applying a note onto a printed document that exits from an image forming apparatus, the finishing unit comprising:a note cutting unit for cutting a sheet of paper to a note of a desired size, wherein the note cutting unit includes a vertical paddle for keeping the paper in proper vertical orientation; and
a note pasting unit for applying the note onto the printed document that exits from the image forming apparatus.

US Pat. No. 10,138,087

DEVICE FOR CONTROLLING THE WEB TENSION IN A RUNNING MATERIAL WEB

1. A device for controlling axial forces acting upon a web which is unwound from a horizontal rotatable shaft and is led up to and wound onto a corresponding horizontal rotatable shaft, wherein the device comprises a first roller, which is rotatable about a first horizontal shaft, a second roller, which is rotatable about a second horizontal shaft, and a third roller, which is rotatable about a third horizontal shaft, wherein the third roller is placed between the first and second rollers and is movable along an arc-shaped motional path in the vertical plane between a lower position and an upper position in response to axial forces acting at any moment upon the web, wherein the web is intended to be led with one side in contact with the first and second rollers and with another side in contact with the third roller, wherein the third roller, in the upper position, is at a vertical distance above the first and second rollers to form an open horizontal passage through which the web can pass freely between the first and second rollers and the above-situated third roller, wherein the third roller is biased with a force which counters the motion of the third roller in the direction of the upper working position and which is less than an ultimate tensile strength of the web.

US Pat. No. 10,138,085

CLEAR CARD SENSORS

ZIH Corp., Lincolnshire,...

1. A media conveyance apparatus comprising:a first light sensor positioned on a first side of a media conveyance path, the first light sensor to generate a first signal indicative of a first amount of light received by the first light sensor;
a light source positioned on a second side of the media conveyance path;
a second light sensor positioned on the second side of the media conveyance path, wherein the second light sensor is to compensate for an environmental change by detecting a second amount of light transmitted by the light source regardless of the presence or absence of media along the media conveyance path, the first light sensor and the light source being positioned such that the media passes between the first light sensor and the light source along the media conveyance path; and
presence determination circuitry configured to:
compare the first signal to a second signal received from the second sensor;
detect a reflection loss based on the comparison of the first and second signals; and
if the reflection loss is detected based on the comparison of the first and second signals, generate a media present indication.

US Pat. No. 10,138,084

IMAGE FORMING APPARATUS AND GUIDANCE METHOD FOR PAPER FEEDING WORK

KABUSHIKI KAISHA TOSHIBA,...

1. An image forming apparatus comprising:an accommodation unit configured to accommodate both of a paper bundle and a packaging member therein in a state in which at least one of the paper bundle and the packaging member used to package the paper bundle satisfies predetermined conditions;
a notification unit configured to perform a notification of guidance on the predetermined conditions;
a first sensor configured to detect that the paper bundle is accommodated in the accommodation unit;
a roller configured to send a paper sheet included in the paper bundle;
a second sensor configured to detect a behavior of the paper sheet sent by the roller; and
a control unit configured to control the notification unit to perform a notification of the guidance when a behavior of the paper sheet is not detected by the second sensor if the first sensor detects that the paper bundle is accommodated in the accommodation unit, and the roller is driven; and
a restriction member configured to restrict movement of a leading end of the paper sheet,
wherein, if the roller is driven in a state in which movement of the leading end of the paper sheet is restricted by the restriction member, the control unit controls the notification unit to perform a notification of the guidance when bending of the paper sheet is not detected by the second sensor.

US Pat. No. 10,138,081

PAPER FEEDING ROLLER WITH PATTERN

KIANA ANALYTICS INC., Su...

1. A feeding roller having an external surface used for a document conveying apparatus comprising:a plurality of groove portions arranged with a regular interval in a width direction of the feeding roller and formed into the external surface of the feeding roller; and
a projection portion provided on the external surface between each pair of adjacent groove portions and formed in a single continuous portion from one edge to the other edge of the feeding roller in the width direction that scrapes off paper particles,
wherein the projection portion has a waveform shape extending in the width direction of the feeding roller and wherein the waveform shape is a trapezoid waveform shape in a view from an outer side in a radius direction of the feeding roller,
wherein a diameter of the external surface where a groove portion is formed is less than a diameter of the external surface where no groove portion and no projection portion are formed,
wherein a diameter of the external surface where a projection portion is formed is larger than said diameter of the external surface where no groove portion and no projection potion are formed, and
wherein each of the plurality of groove portions include a bottom portion formed by the external surface.

US Pat. No. 10,138,076

METHOD FOR RESIN DELIVERY INCLUDING METERING INTRODUCTION OF EXTERNAL AIR TO MAINTAIN DESIRED VACUUM LEVEL

1. Apparatus for pneumatically conveying granular plastic resin material out of a resin supply to at least one receiver, consisting of:a) a vacuum pump having a suction intake;
b) a first conduit connecting the resin supply to the receiver;
c) a second conduit connecting the receiver to the suction intake;
d) means for monitoring the level of vacuum being drawn by the vacuum pump at the suction inlet;
e) a valve responsive to the means for monitoring for supplying air to the conduit at a location proximate the resin supply in an amount to maintain a desired level of vacuum, at the vacuum pump suction inlet, drawn by the vacuum pump.

US Pat. No. 10,138,072

PRODUCT CONVEYING DEVICE

BOE TECHNOLOGY GROUP CO.,...

1. A conveyor comprising:a conveyor belt, a sensor and a controller,
wherein the sensor comprises a light ray generator and a light ray receiver each disposed at two opposing sides of an end of the conveyor belt and at least one baffle disposed between the light ray generator and the light ray receiver,
wherein a conveyed product impinges the at least one baffle when the conveyed product is conveyed to the vicinity of the end of the conveyor belt, the controller is connected with the light ray receiver for controlling the conveyor belt to stop moving in response to a signal fed back by the light ray receiver that the conveyed product has been conveyed to the end of the conveyor belt,
wherein the baffle has a light transmission hole to let the light ray emitted from the light ray generator pass through,
wherein a gap between a lower edge of the baffle and the conveyor belt is smaller than the thickness of the conveyed product; when the baffle is impinged by the conveyed product, the baffle will move along a conveying direction of the conveyor belt so as to block the light ray emitted from the light ray generator.

US Pat. No. 10,138,071

COUNTERWEIGHT STACKER

McCloskey International L...

1. A stacking system for conveying bulk material, including a conveyor frame designed to support a conveyor belt, the conveyor frame including forward and rear portions, a hopper designed to receive the bulk material, the hopper being mounted to the rear portion of the conveyor frame, an engine for providing power to the stacking system, a drive pulley for driving the belt, and an idler pulley disposed generally below the hopper, the improvement comprising:a counterweight disposed generally above the conveyor belt, immediately to the rear of the hopper.

US Pat. No. 10,138,070

FRICTION CONVEYING SYSTEM

Guangzhou MINO Automotive...

1. A friction conveying system, comprising:a friction driving unit, comprising:
a rotation driving component;
a first connecting rod;
a second connecting rod;
at least one first roller arranged on the first connecting rod; and
at least one second roller arranged on the second connecting rod;
a clamping unit, comprising a clamping driving component; and
a friction driving component;
wherein:
by the clamping driving component, the first connecting rod and the second connecting rod are moved towards each other, to cause the at least one first roller and the at least one second roller by circumferential surfaces thereof to clamp the friction driving component;
by the rotation driving component, the at least one first roller and/or the at least one second roller are rotated, to cause the friction driving component clamped therebetween to move, by means of frictional force;
the at least one first roller comprises a main driving roller and an auxiliary driving roller arranged on the first connecting rod in a conveying direction and driven by the rotation driving component to rotate synchronously; and
the at least one second roller comprises two driven rollers arranged on the second connecting rod in the conveying direction and corresponding to the main driving roller and the auxiliary driving roller respectively.

US Pat. No. 10,138,069

TAKE-UP MECHANISM FOR CONVEYOR SYSTEM

Joy Global Underground Mi...

1. A device for a tensioning mechanism of a conveyor system, the conveyor system including a continuous belt and a first carriage coupled to a drive unit and supported for movement, the device comprising:an anchor structure; and
a second carriage including at least one second roll for supporting a portion of the belt, the second carriage being securable to the anchor structure, a distance between the first carriage and the second carriage defining a take-up length,
when the second carriage is unsecured with respect to the anchor structure, a tension in the belt causes the second carriage to move relative to the anchor structure between a first position and at least one second position, movement of the second carriage modifying the take-up length.

US Pat. No. 10,138,068

POWERED ROLLER SYSTEMS AND METHODS

TECH-ROLL INC., Blaine, ...

1. A powered roller system comprising:a roller drum assembly comprising a drum member, a drum shaft, and a drum bearing assembly;
a motor comprising a support shaft and a drive shaft, where the drum bearing assembly is arranged to support the drum member on the support shaft;
a proximal support assembly for supporting the drum shaft, the proximal support assembly comprising
a support block defining center bore, first and second fluid bores, and first and second O-ring grooves;
first and second O-rings arranged within the first and second O-ring grooves, respectively, wherein
the first and second fluid bores extend between first and second fluid ports and first and second locations of the center bore;
the center bore is sized and dimensioned such that, with the support shaft is arranged within the center bore, the O-rings engage the support shaft to define a sealed area and the first and second locations are within the sealed area; and
a distal support assembly for supporting the drum shaft.

US Pat. No. 10,138,067

JACKLADDER FLIGHT MEMBER WITH REPLACEABLE OR ROTATABLE WEAR COMPONENT

CRUCIBLE, LLC, Birmingha...

1. A jackladder flight member assembly comprising:a) a base plate having a front surface, a rear surface, a top surface and a bottom surface;
b) at least one chain link connector coupled to the base plate;
c) at least one wear plate component wherein the wear plate component comprises a horizontal symmetric transverse cross section and is further configured to be coupled to the base plate at a zero degree rotation position and a one hundred eighty degree rotation position relative to a coupling means axis and wherein the transverse cross section of the wear plate component is generally C-shaped having a front surface plate, a top flange plate, and a bottom flange plate; and
d) the at least one wear plate component removably coupled to the base plate covering at least a portion of the front surface, top surface, and bottom surface of the base plate.

US Pat. No. 10,138,036

BEVERAGE CONTAINER SOUND DEVICE

1. A noise producing beverage container comprising:a container having a surface which includes an opening initially sealed with a tongue in the surface opening;
a pull tab disposed on the surface adjacent the tongue; and
a sound making device having a reed, the sound making device attached to the interior of the container adjacent the sealed opening, the tongue movable upon rotating the pull tab to contact the sound making device;
wherein the sealed opening is initially in a closed position and upon opening the sealed opening the tongue contacts a free end of the reed, bends the reed and releases the reed, the reed producing a percussion sound upon release.

US Pat. No. 10,138,033

SPOUT ASSEMBLY FOR A FLEXIBLE BAG

Scholle IPN Corporation, ...

1. A spout for a flexible bag comprising:a base flange having a top surface and a bottom surface opposite the top surface, at least one of the top surface and the bottom surface configured for coupling to a flexible bag;
a cylindrical upstand extending from the base flange away from the top surface of the base flange, the cylindrical upstand including a proximal end corresponding to the base flange, and a distal end spaced apart therefrom, the body including an inner surface and an outer surface, with the inner surface configured for placement in fluid communication with a cavity of the flexible bag;
a lower body flange spaced apart from each of the base flange and the distal end of the cylindrical upstand;
an upper body flange spaced apart from each of the lower body flange and the distal end of the cylindrical upstand; and
a dual lead thread extending along the outer surface of the cylindrical upstand between the proximal end and the distal end, the dual lead thread having a lower portion of a first threadform and a lower portion of a second threadform, each of the lower portions of the first and second threadforms positioned on opposing sides and each forming a partial thread, each of the lower portions of the first threadform and second threadform having a first end that extends outwardly from the cylindrical upstand between the distal end of the cylindrical upstand and the upper body flange, and with a second end that extends into and over the upper body flange.

US Pat. No. 10,138,032

FASTENER ASSEMBLY

1. A fastener assembly being disposed at a lateral edge of a container, comprising:a first fixing member disposed at the lateral edge of the container, and comprising two engaging ends;
two second fixing members disposed at the lateral edge of the container, and each comprising a fixing seat and a pivot ear, each of the fixing seats including a pivot recess and a restricting recess, each of the pivot ears including a pivot end and an engaging recess, the pivot ends of the pivot ears being pivoted in the pivot recesses of the fixing seats, respectively; and
a retaining member disposed at the lateral edge of the container, wherein the retaining member is provided with two restricting ribs on an inner surface thereof, and two push ribs at two ends thereof, the restricting ribs of the retaining member are restricted in the restricting recesses of the fixing seats, respectively, and the push ribs are abutted against the two pivot ears, so as to prevent the pivot ears from pivoting outward;
the container comprises an upper cover and a lower cover which are pivoted to each other by a pivot portion and capable of being closed and opened relative to each other, a receiving recess is formed at the lateral edge of the container, each of the upper and lower covers is provided with a receiving space, and the receiving spaces of the upper and lower covers are combined to form the receiving recess.

US Pat. No. 10,138,029

CONTAINER LID HAVING MEASURING FUNCTION

7. A container lid having a measuring function, the container lid comprising:a valve body configured to be mounted on an entrance of a container, to have a through hole that communicates with an internal space of the container, and to have a valve that closes or opens the through hole; and
a cap configured to be screwed on the entrance of the container, and to have a connection part that is connected to or separated from a valve stem of the valve;
wherein the cap is placed in any one of: a first position where the valve opens the through hole in a state where the connection part has been connected to the valve stem; a second position where the valve closes the through hole in a state where the connection part has been connected to the valve stem; and a third position where the connection part is removed from the valve stem and also the cap is separated from the container in a state where the valve has closed the through hole, wherein:
the valve body comprises a bottom surface configured to form a valve seat, a valve guide formed to protrude from the bottom surface toward the entrance of the container, the through hole formed to pass through an area around the valve guide, and the valve inserted into the valve guide;
the valve body further comprises a cylindrical outer wall formed to extend from the bottom surface, and a second outer wall configured to form an annular space, open toward the bottom surface, at a lower end of the outer wall; and
an outer circumferential surface of the outer wall is provided with a first screw portion to which the cap is coupled, and an inner circumferential surface of the second outer wall is provided with a second screw portion to be engaged with the screw portion of the entrance of the container or a protrusion to be caught on a projection formed on the entrance of the container.

US Pat. No. 10,138,028

SELF-PRIMING-PUMP EQUIPPED PACKAGING BOTTLE

ANHUI JND PLASTIC PACKAGI...

1. A self-priming-pump-equipped packaging bottle, comprising: a tubular bottle body, a piston, an upper seal assembly, and a lower seal assembly; the piston being installed in a lower part of the tubular bottle body; the upper seal assembly being fixed in an upper part of the tubular bottle body; the lower seal assembly being fixed in a middle part of the tubular bottle body between the piston and the upper seal assembly; the upper seal assembly, the lower seal assembly and the tubular bottle body jointly forming a closed material-feeding chamber; and the lower seal assembly, the piston, and the tubular bottle body jointly forming a closed material-storing chamber;the lower seal assembly including a seal seat and an elastic sealing gasket, the seal seat having a through hole communicating the material-feeding chamber and the material-storing chamber, the elastic scaling gasket covering the through hole from a side corresponding to the material-feeding chamber; and the seed seat is in connection with the tubular bottle body; and
the upper seal assembly having an umbrella-shaped member, a hollow material-feeding column, a support post, and an end scaling cap; the end sealing cap being fixed inside the umbrella-shaped member through the support post; an outer wall of the hollow material-feeding column closely fitting the support post and extending inward from an opening at an upper end of the umbrella-shaped member; a bottom surface of the hollow material-feeding column, the support post, and the end sealing cap jointly forming a material outlet; and a lower end of the umbrella-shaped member being in interference fit with the seal seat; wherein the elastic sealing gasket includes a circular ring, a seal plate located at a center of the circular ring, and a connecting strip that connects the circular ring and the seal plate, in which the circular ring, the seal plate, and the connecting strip am integrated as a unit, and the seal plate is smaller than the circular ring in terms of thickness.

US Pat. No. 10,138,027

PLUG FOR BEVERAGE CONTAINER LID

StixToGo, Inc., Bothell,...

1. A beverage container packaging system, for temporarily sealing a drinking orifice in a lid of a beverage container, comprising:a beverage container having a rim around the bottom of the container, the rim creating a recessed area outside of the container and on the bottom of the container; and
a plug comprising
a body portion having an upper surface, a lower surface, and a cap portion disposed on the upper surface, the cap portion configured such that the cap portion's cross-sectional dimension exceeds the cross-sectional dimension of the body portion to provide a limit to the insertion of the plug into the orifice;
a first sidewall disposed between the upper surface and the lower surface of the body portion, and a second sidewall disposed between the upper surface and the lower surface of the body portion, the first and second sidewalls disposed on opposite sides of the body portion, the first sidewall having a first circumferential depression located in the sidewall; and
an elongate projection of uniform width extending from the lower surface to a length sized such that the plug fits inside the rim and within the recess of the beverage container.

US Pat. No. 10,138,026

RESEALABLE FLEXIBLE PACKAGE AND METHOD OF USING THE SAME

SONOCO DEVELOPMENT, INC.,...

1. A flexible package comprising:a first panel and a second panel that are formed by a flexible material, the first panel being attached to the second panel to form an interior cavity, between the first panel and second panel, in which content is stored; and
an activatable adhesive that is located on an exterior surface of the first panel or the second panel, the adhesive having an inactive state and an active state,
wherein the inactive state precludes the adhesive from bonding with a separate portion of the first or second panel,
wherein the active state is achieved by roughening, rubbing, heating, or scraping the adhesive and, when activated, enables the adhesive to bond with a separate portion of the first or second panel; and
a seal between the first panel and the second panel which defines an openable access point for the package,
wherein the activatable adhesive is disposed on an exterior of the first panel in the location of the seal, and
wherein when the package is in a resealed position, the activated adhesive is releasably bonded to an interior surface of the second panel.

US Pat. No. 10,138,017

LOADED PALLET CONTAINER

1. A loaded pallet container, comprising:a rectangular container body soleplate;
a front enclosure plate, a rear enclosure plate, a left enclosure plate, and a right enclosure plate, wherein the front enclosure plate, rear enclosure plate, left enclosure plate, and right enclosure plate are vertically disposed on the container body soleplate;
a rectangular accommodating cavity defined by the container body soleplate, the front enclosure plate, the rear enclosure plate, the left enclosure plate, and the right enclosure plate;
a cover being matched with and covering an upper opening of the accommodating cavity; and
a horizontal rotating shaft suspended on an outer wall surface of the rear enclosure plate close to the upper opening of the accommodating cavity,
wherein a horizontal long hole is provided on a left side surface and a right side surface of the cover corresponding to two ends of the horizontal rotating shaft, respectively, and the cover is rotationally connected to the horizontal rotating shaft through the horizontal long holes,
a bottom edge of each of the front enclosure plate and the rear enclosure plate horizontally extends outward to form a lower flange,
a bottom edge and two side edges of each of the left enclosure plate and the right enclosure plate horizontally extend outward to form a side enclosure plate lower flange and side enclosure plate side flanges, and
the lower flange is horizontally resisted against the side enclosure plate lower flange on a corresponding upper surface of the container body soleplate and kept in flexible connection thereto, and the side enclosure plate side flanges are horizontally resisted against corresponding inner side surfaces of the front enclosure plate and the rear enclosure plate and kept in flexible connection thereto.

US Pat. No. 10,138,015

METHOD FOR CONTROLLING A LABELING MACHINE, LABELING UNIT AND CONTAINER HANDLING SYSTEM

KHS GmbH, Dortmund (DE)

1. An apparatus comprising a labeling machine for applying labels onto containers in a container flow, said labeling machine comprising a label-strip feed, a retainer, a labeling unit, an active strip-store, a dancer roller, a first controllable drive, a second controllable drive, and a third controllable drive, wherein said labeling unit transfers a label to a container located at a labeling position of said labeling machine, wherein said active strip-store is disposed between said labeling unit and said label-strip feed, wherein said first, second, and third controllable drives are controllable independently of each other, wherein said retainer retains a label-strip roll, wherein said first drive controls operation of said label-strip feed, wherein said second drive controls operation of said labeling unit, and wherein said third drive controls operation of said dancer roller, wherein said labeling machine is a constituent of a block-form container handling system, wherein said active strip-store is configured to transition between a first operating mode and a second operating mode, wherein, in said block-form container handling system, containers are transported via a transport stretch into an container inlet of said labeling system in a container flow that defines a particular spacing interval between containers in said flow, wherein said first operating mode is a labeling mode during which containers present at said labeling position are labeled, wherein said second operating mode is a non-labeling mode in which no container is present at said labeling position, and wherein said active strip-store is configured to transition between said first and second operating modes in response to a control signal that is generated in response to detecting a forthcoming gap in said container flow.

US Pat. No. 10,138,007

UNIT AND METHOD FOR FILLING CONTAINING ELEMENTS OF SINGLE-USE CAPSULES FOR EXTRACTION OR INFUSION BEVERAGES

GIMA, S.P.A., Zola Predo...

1. A filling unit for filling containing elements (2) of single-use capsules (3) with a dose (33) of product for extraction or infusion beverages, comprising:a transport line (4) for transporting the containing elements (2) extending along a first movement path (P) and provided with a plurality of supporting seats (5) for the containing elements (2) arranged in succession along the first movement path (P);
a filling station (SR) for filling the above-mentioned containing elements (2) with a dose (33) of product;characterised in that the filling station (SR) comprises:at least one first containing seat (S1) designed to receive a dose (33) of product and movable along a second movement path (P1);
a forming substation (ST1) for forming the dose (33) inside the at least one first containing seat (S1), provided with a releasing device (6) for releasing a predetermined quantity of product forming the dose (33) inside the at least one first containing seat (S1);
at least one second containing seat (S2) designed to receive the dose (33) of product from the at least one first containing seat (S1) and movable along a third movement path (P2);
a transfer substation (ST2) for transferring the dose (33) of product from the at least one first containing seat (S1) to the at least one second containing seat (S2);
first devices (7) for moving the at least one first containing seat (S1) between the forming substation (ST1) and the transfer substation (ST2) and vice versa;
a release substation (ST3) for releasing the dose (33) of product from the at least one second containing seat (S2) to a containing element (2) transported by the transport line (4);
further second devices (8) for moving the at least one second containing seat (S2), designed to move the second containing seat (S2) along the third movement path (P2) from the transfer substation (ST2) to the release substation (ST3) and vice versa, the transfer substation (ST2) and the release substation (ST3) being positioned at a predetermined distance from one another along the third movement path (P2), the third movement path (P2) being parallel to the first movement path (P) of the transport line (4) at the release substation (ST3);wherein the at least one first containing seat (S1) is defined by lateral walls of a cavity (18) and by a bottom wall (F), the filling unit comprising, for each first containing seat (S1):a piston (13) movable between a lower position where it defines the bottom wall (F) of the at least one first containing seat (S1) and an upper position where it closes the top of the cavity (18);
means (14) for moving the piston (13), for moving the piston (13) between the lower and upper positions; andwherein the means (14) for moving the piston (13) are designed to position the piston (13) in a compacting position, which is intermediate between the lower position and the upper position, in a compacting region (R4), to compact the dose (33) of product; the filling unit further comprising a control and drive unit (15), connected to the means (14) for moving the piston (13) and configured for moving the piston (13) from the lower position to the upper position at the transfer substation (ST2) so as to transfer the dose (33) from the at least one first containing seat (S1) to the at least one second containing seat (S2).

US Pat. No. 10,138,004

FLYWHEEL DEVICE FOR POSITION STABILIZATION OF A SPACECRAFT

Rockwell Collins Deutschl...

1. A flywheel device for position stabilization of a spacecraft, the flywheel device comprising:a carrier;
a rotor;
a magnetic drive configured to drive the rotor rotatingly relative to the carrier; and
a roller bearing arranged between the rotor and the carrier,
wherein the magnetic drive is configured to generate a magnetic force between the rotor and the carrier for pre-stressing the roller bearing,
wherein an outer diameter of the rotor is at most 2.5 times a diameter of the roller bearing.

US Pat. No. 10,137,999

METHODS AND APPARATUS FOR DETECTING AIRFLOW CONTROL SURFACE SKEW CONDITIONS

The Boeing Company, Chic...

1. An apparatus comprising:an aircraft wing;
a support linkage;
a flap coupled to the aircraft wing via the support linkage;
a sensor coupled to the flap at a location proximate to the support linkage, the sensor configured to generate first vibration data for the location; and
a detector communicatively coupled to the sensor, the detector to:
identify a change in a rotational constraint of the flap relative to the support linkage based on a shift in a peak of the first vibration data relative to a peak of second vibration data; and
detect a skew condition of the flap based on the change.

US Pat. No. 10,137,993

MIXING BLEED AND RAM AIR USING AN AIR CYCLE MACHINE WITH TWO TURBINES

HAMILTON SUNDSTRAND CORPO...

1. An air cycle machine for an environmental control system for an aircraft, the air cycle machine comprising:a compressor configured to compress a first medium;
a turbine configured to receive second medium;
a mixing point downstream of the compressor and downstream of the turbine; and
a shaft mechanically coupling the compressor and the turbine;
a second turbine mounted on the shaft and configured to expand the first medium,
wherein the environmental control system comprises a fan driven by a third turbine driven by the second medium.

US Pat. No. 10,137,991

TRAY TABLE DEPLOYABLE FROM LOWER SEATBACK AREA

1. A passenger seat comprising:a tray table support bracket comprising:
at least one support arm haying a proximal end configured to hingedly couple to a passenger seatback, the at least one support arm operable to pivot between a stowed position in which a distal end of the at least one support arm is oriented to be substantially parallel to the seatback, and a deployed position in which the distal end of the at least one support aim is displaced away from the seatback,
a guide member extending between the distal end and the proximal end of the at least one support arm; and
a rocker actuator disposed at the distal end of the at least one support arm;
a tray table coupled to the tray table support bracket and configured to provide a substantially horizontal work surface when in a deployed state, the tray table comprising:
a hinge base portion in a slidable engagement relationship with the guide member and being rotatably coupled to the at least one support arm about a lateral axis of rotation when the hinge base is positioned proximate to the distal end of the at least one support arm, and
an extension portion configured to define a work surface, the extension portion being in a controlled slidable engagement relationship with the hinge base portion; and
a rocker latch pivotably coupled to the hinge base portion and operable to pivot between a locked position corresponding to a partially deployed state of the binge base portion and an unlocked position corresponding to a fully deployed state of the hinge base portion;
wherein the rocker actuator comprises a spring bias mechanism directed downward to engage a proximal end of the rocker latch in response to the hinge base portion rotating about the lateral axis of rotation toward the fully deployed state of the hinge base portion; and
wherein when in the locked position, a distal end of the rocker latch engages and retains the extension portion in a retracted position relative to the hinge base portion, and wherein when in the unlocked position, the distal end of the latch disengages the extension portion such that the extension portion is free to slide distally relative to the hinge base portion, the latch being configured to automatically unlock responsive to the hinge base portion rotating about the lateral axis of toward the fully deployed state.

US Pat. No. 10,137,989

CONSTRUCTION KIT AND METHOD FOR A HOUSING STRUCTURE OF A MONUMENT FOR A VEHICLE CABIN

Airbus Operations GmbH, ...

1. A vehicle cabin monument housing construction kit, the kit comprising:a plurality of integrally formed sandwich panels, each of the sandwich panels having a first and a second cover panel surrounding a core, and formed with panel connecting structures, each of the panel connecting structures formed as a plug region or as a mating plug region,
wherein the construction kit further comprises:
at least one fastening rail having a receiving space extending along the longitudinal direction of the at least one fastening rail, the receiving space being configured to receive and fasten mounting feet of fixing elements to the at least one fastening rail to fix the monument in position inside the cabin,
wherein the at least one fastening rail is formed with rail-to-panel connecting structures, each of the rail-to-panel connecting structures formed as a plug region or as a mating plug region, and
wherein the mating plug region of any of the sandwich panels and the at least one fastening rail is formed to be complementary to the plug region of any of the sandwich panels and the at least one fastening rail, and the plug region of any of the sandwich panels and the at least one fastening rail is formed to be complementary to the mating plug region of any of the sandwich panels and the at least one fastening rail, so that the at least one fastening rail is configured to be plugged together with at least one of the plurality of sandwich panels at least one of the plurality of sandwich panels with the plug region is configured to be plugged together with one of the plurality of sandwich panels with the mating plug region.

US Pat. No. 10,137,988

TOILET SYSTEM AND METHOD OF ASSEMBLING

The Boeing Company, Chic...

1. A toilet system comprising:a waste receptacle comprising an outlet configured to channel waste therethrough; and
a conveyor assembly comprising:
a housing that comprises an inlet and at least one outlet comprising a solid waste outlet and a liquid waste outlet, said inlet coupled in direct flow communication with said outlet of said waste receptacle such that both liquid waste and solid waste are received within said housing from said waste receptacle, said solid waste outlet positioned to receive solid waste transported by said transport mechanism, and said liquid waste outlet positioned to receive liquid waste separated from the solid waste; and
a transport mechanism positioned within said housing, said transport mechanism operable to actively transport the waste from said inlet towards said at least one outlet of said housing.

US Pat. No. 10,137,987

MOBILE GALLEY CART WITH HEATING, COOLING AND BRAKING FUNCTIONALITY

1. An aircraft galley cart, comprising:a housing comprising a bottom, a top, two side walls, a first end wall, and a second end wall;
a first handle assembly mounted to an upper end of the first end wall;
a second handle assembly mounted to an upper end of the second end wall, wherein each of the first handle assembly and the second handle assembly includes an articulating member that moves between a first position when the handle assembly is grasped by a user and a second position when the handle assembly is not being grasped by the user;
at least four wheels, wherein each wheel of the at least four wheels is mounted proximate to a respective corner of four corners of the bottom of the housing;
at least one braking assembly configured to selectively engage or disengage a wheel brake on one or more of the at least four wheels; and
a cabling assembly connecting each of the first handle assembly and the second handle assembly to the at least one braking assembly, wherein the cabling assembly is configured to disengage the at least one braking assembly upon actuation of the articulating member of either of the first handle and the second handle to the first position, and to engage the at least one braking assembly upon actuation of the articulating member of both the first handle assembly and the second handle assembly to the second position, wherein the cabling assembly comprises:
a first cable routed from one end of the first handle assembly, down a first side of the first end wall, along the bottom of the housing and communicatively connecting to the at least one braking assembly, and up a second side of the first end wall to a second end of the first handle assembly; and
a second cable routed from one end of the second handle assembly, down a first side of the second end wall, along the bottom of the housing and communicatively connecting to the at least one braking assembly, and up a second side of the second end wall to a second end of the second handle assembly;
wherein the at least one braking assembly is configured for independent actuation by the first handle assembly and the second handle assembly, wherein
the at least one braking assembly engages the wheel brake on the one or more of the at least four wheels when the respective articulating member of both the first handle assembly and the second handle assembly are simultaneously in the second position, and
the at least one braking assembly disengages the wheel brake on the one or more of the at least four wheels when the respective articulating member of either the first handle assembly or the second handle assembly is in the first position.

US Pat. No. 10,137,986

AIRLIFT PACKAGE PROTECTION AIRBAG CONTAINER

Amazon Technologies, Inc....

1. A container configured to protect an item during transport to a destination, the container comprising:an inflatable portion that includes inflatable sidewalls that connect an inflatable cover to an inflatable base, at least the inflatable sidewalls formed from an elongated tubular inflatable vessel arranged as a helix defining a non-pressurized internal cavity to secure the item therewithin, the elongated tubular inflatable vessel having a filling orifice to inflate the inflatable sidewalls, the inflatable cover, and the inflatable base with gas; and
two or more apertures through the inflatable cover that enable coupling arms to couple to the item in the non-pressurized internal cavity during transport while the elongated tubular inflatable vessel is inflated.

US Pat. No. 10,137,985

STEALTH AERIAL VEHICLE

Airbus Defence and Space ...

1. A method of operating an aerial vehicle, the method comprising the acts of:taking off the aerial vehicle in a second attitude in which a first side faces down, wherein the first side of the aerial vehicle has a landing gear bay, and wherein a second side of the aerial vehicle has no bays, has a smaller radar signature than the first side and is arranged opposite to the first side of the aerial vehicle;
retracting a landing gear into the landing gear bay that is arranged on the first side;
switching from the second attitude to a first attitude in which the second side faces in a direction of a threat during a portion of flight of the aerial vehicle;
switching from the first attitude to the second attitude in which the first side faces down;
extending the landing gear while the aerial vehicle is in the second attitude; and
landing the aerial vehicle in the second attitude in which the first side faces down.

US Pat. No. 10,137,984

SYSTEMS AND METHODS FOR OPERATING DRONES IN RESPONSE TO AN INCIDENT

State Farm Mutual Automob...

1. A response drone for detecting incidents within a coverage area including a plurality of zones, the response drone comprising a processor, a memory in communication with the processor, and a sensor, wherein the processor is programmed to:detect a triggering activity associated with a first zone of the plurality of zones;
determine a navigation path to the first zone;
travel to the first zone based upon the determined navigation path;
collect sensor data using the sensor at the first zone;
detect items located within the first zone and associate each of the detected items with an identifier and a location within the first zone;
compare the detected items to a virtual inventory stored in the memory of items within the first zone;
identify a difference between the detected items and the stored items of the virtual inventory;
tag a point of interest within the first zone based upon a stored location of the difference by associating an identifier and a location with the point of interest and storing the identifier and the location within the memory;
trigger an insurance event based upon the tagged point of interest; and
transmit an alert to a user computing device associated with a user to notify the user of the triggered insurance event, wherein the alert includes the collected sensor data with the tagged point of interest.

US Pat. No. 10,137,979

AIRCRAFT AND MISSILE FOREBODY FLOW CONTROL DEVICE AND METHOD OF CONTROLLING FLOW

Orbital Research Inc., C...

1. A method of stabilization and maneuvering a missile or aircraft comprising the steps ofa. estimating or determining side forces on a missile or an aircraft forebody based at least in part on a signal from at least one sensor; the missile or aircraft further comprising at least one deployable and retractable flow effector on the missile or aircraft forebody and a closed loop control system for controlling the at least one deployable and retractable flow effector at least in part by indirectly estimating or determining flow separation, or estimating or determining side forces on the forebody based on the signal from at least one sensor;
b. activating the at least one deployable and retractable flow effector to counteract or change the side forces by activation of the at least one deployable and retractable flow effector with the closed loop controller based on at least in part the signal of the at least one sensor;
c. re-estimating or determining side forces on the missile or aircraft forebody based at least in part on a signal from the at least one sensor; and
d. deactivating the at least one deployable and retractable flow effector by retracting the flow effector to a position at or beneath the surface of the missile or aircraft in response to reduced or changed side forces.

US Pat. No. 10,137,978

FOLDING WING TIP DEVICE WITH ROTATABLE LOCK

AIRBUS OPERATIONS LIMITED...

1. An aircraft, comprising:an aircraft wing, the aircraft wing comprising a fixed wing and a wing tip device at the tip thereof, wherein the wing tip device is configurable between:
(i) a locked flight configuration for use during flight and (ii) a ground configuration for use during ground-based operations, in which ground configuration the wing tip device is moved away from the locked flight configuration such that the span of the aircraft wing is reduced, the aircraft wing further comprising a locking mechanism for locking the wing tip device in the locked flight configuration, the locking mechanism having a longitudinal axis and comprising a first part associated with one of the fixed wing and the wing tip device, and a second part associated with the other of the fixed wing and wing tip device,
the locking mechanism having a locked configuration, in which the first part is received in the second part such that the first part is prevented from being withdrawn from the second part along the longitudinal axis of the locking mechanism, and an unlocked configuration, in which the first part is received in the second part such that the first part is free to be withdrawn from the second part along the longitudinal axis of the locking mechanism, wherein the locking mechanism is moved between the locked configuration and the unlocked configuration by rotation of at least one of the first part or second part around the longitudinal axis of the locking mechanism,
wherein the first part is a male locking pin having a longitudinal axis shared with the locking mechanism, with one or more flanges extending in a direction perpendicular to the longitudinal axis of the locking pin,
wherein the second part is a female receiving portion, with an opening aperture shaped to allow passage of the male locking pin in a longitudinal direction when the locking mechanism is in the unlocked configuration, and
wherein the female receiving portion comprises at least one internal receiving chamber, the receiving chamber arranged to receive a flange of the male locking pin and prevent longitudinal movement of the male locking pin when the locking mechanism is in the locked configuration.

US Pat. No. 10,137,974

MONUMENT FOR A CABIN OF A VEHICLE, AND FASTENING ARRANGEMENT

AIRBUS OPERATIONS GMBH, ...

1. A monument for a cabin of a vehicle, comprising:an outer housing side; and
a fastening rail for fastening connection elements in a longitudinal direction of the fastening rail in order to fix the monument in position inside the cabin,
the fastening rail having a receiving space extending in the longitudinal direction of the fastening rail, which space is designed to receive and fasten a plurality of mounting feet of the connection elements to the fastening rail, and being embedded in the outer housing side.

US Pat. No. 10,137,973

PROPULSION CONTROL SYSTEM AND METHOD FOR CONTROLLING A MARINE VESSEL

1. A propulsion control system for controlling a marine vessel comprising a propulsion unit set which in turn comprises at least four propulsion units, the marine vessel comprising a longitudinal centre line and a transversal line, the transversal line extending in a direction perpendicular to the longitudinal centre line and also extends through the steering axis of an aftmost of the propulsion units, the marine vessel comprising four quadrants defined by the longitudinal centre line and the transversal line, wherein a first and a second quadrant are located on the same side of the longitudinal centre line, the propulsion control system being adapted to receive an input command from a vessel steering control arrangement, wherein, if the input command is indicative of a combined sway and yaw motion being desired, the propulsion control system is adapted to control the propulsion unit set such that:each one of a first, a second, a third and a fourth propulsion unit of the propulsion unit set produces a thrust in a direction that forms an angle with the longitudinal centre line;
each one of the first, second and third propulsion unit of the propulsion unit set produces a thrust in a direction towards the first quadrant;
the fourth propulsion unit of the propulsion unit set produces a thrust in a direction towards the second quadrant, and
the magnitude of the thrust produced by each of the first and the fourth propulsion unit is greater than the magnitude of the thrust produced by each one of the second and the third propulsion unit.

US Pat. No. 10,137,969

FACE MASK WITH MOUNT FOR IMAGING DEVICE

Sport Dimension Inc., Ca...

1. An assembly, comprising:a mask having a frame that includes a right lens frame attached to a left lens frame by a bridge that supports a nosepiece, with a lens retained inside each of the right lens frame and the left lens frame, the frame further including a top surface and a connection region that is cut out from the top surface of the frame at the location of the bridge;
a support piece seated inside the connection region; and
a filler piece that is adapted to be seated inside the connection region and secured inside the connection region by the support piece, the filler piece having a top surface that is flush with the top surface of the frame when the filler piece is secured at the connection region; and
a mount piece having a bottom section, and a mount support extending vertically from the bottom section, with two or more engagement tabs and a retainer engagement tab provided on the mount support and spaced apart so as to define open transverse slots therebetween suitable for the insertion of a camera mount, wherein the bottom section is adapted to be seated inside the connection region and secured inside the connection region by the support piece when the mount piece is secured to the connection region.

US Pat. No. 10,137,966

SYSTEM AND METHOD FOR PROVIDING RECIRCULATION-BASED ALTERNATING BLOWDOWN SEA CHEST

12. A method for alternating recirculation-based blowdown of a sea chest comprising the steps of:selecting, by a user, a first mode of operation;
selecting, by the user, a time interval corresponding to the first mode;
initiating, utilizing a pump, suction to a sea chest system;
discharging fluid from a discharge port;
recirculating fluid from the discharge port to the sea chest system; and
switching, utilizing a processor, from the first mode to a second mode.

US Pat. No. 10,137,965

SNOWMOBILE WITH LEANING CAPABILITY AND IMPROVEMENTS THEREFOR

1. A rear snowmobile suspension, comprising:a torsion link structure;
a control arm pivotally connected to a first end of the torsion link structure;
a wheel assembly pivotally connected to a second end of the torsion link structure;
a first slide rail attached to the wheel assembly with a sliding mechanism;
further including a second slide rail attached to the wheel assembly opposite the first slide rail; and
a torsion tube disposed between the first slide rail and second slide rail, the torsion tube attached to the first slide rail, second slide rail, and control arm.

US Pat. No. 10,137,964

ELECTRICAL BICYCLE OPERATING SYSTEM, ELECTRICAL DERAILLEUR, AND ELECTRICAL SEATPOST ASSEMBLY

SHIMANO INC., Sakai (JP)...

17. An electrical bicycle operating system comprising:a first switch to generate a first transmission control signal;
a second switch to generate a second transmission control signal; and
a control unit to electrically operate at least one of an electrical bicycle seatpost assembly, an electrical suspension, and a driving unit configured to output an assist force when both the first switch and the second switch are operated concurrently, wherein
the control unit is configured to generate a third signal to operate the at least one of the electrical bicycle seatpost assembly, the electrical suspension, and the driving unit when the control unit receives both the first transmission control signal and the second transmission control signal during more than an operation time period.