US Pat. No. 10,655,488

GAS TURBINE TRANSITION SEAL WITH HOLE THROUGH SEAL PLATE IN GROOVE OF NOZZLE

Mitsubishi Hitachi Power ...

1. A gas turbine, comprising:a compressor that compresses air;
a combustor that burns the air compressed by the compressor with a fuel to thereby generate a combustion gas; and
a turbine driven by the combustion gas generated by the combustor;
the combustor including a transition piece that supplies the turbine with the combustion gas;
the turbine including:
a first turbine stage that includes a nozzle cascade and a blade cascade arranged in sequence along a turbine axial direction;
an inner nozzle end wall and an outer nozzle end wall that define respective inner and outer peripheries of an annular combustion gas flow passage in the nozzle cascade of the first turbine stage, the inner nozzle end wall and the outer nozzle end wall each having an anterior edge facing a posterior edge of the transition piece;
a first gap between the anterior edge of the inner nozzle end wall and the posterior edge of the transition piece, and a second gap between the anterior edge of the outer nozzle end wall and the posterior edge of the transition piece, and
at least one of a first seal member and a second seal member, wherein the first seal member seals the first gap and the second seal member seals the second gap,
wherein the transition piece has a first flange portion and a second flange portion that extend in a turbine radial direction, the first flange portion being disposed on an inner peripheral wall portion of a combustion gas outlet of the transition piece, and the second flange portion being disposed on an outer peripheral wall portion of the combustion gas outlet of the transition piece, the outer peripheral wall portion located radially outward, with respect to the longitudinal axis, of the inner peripheral wall portion,
wherein anterior edges of each of the inner nozzle end wall and the outer nozzle end wall each have a respective seal groove, each seal groove extending in the turbine axial direction,
wherein each seal groove includes a high temperature-side inner wall surface and a low temperature-side outer wall surface, wherein the high temperature-side inner wall surface of each seal groove is located closer to the annular combustion gas flow passage than the low temperature-side outer wall surface of the respective seal groove,
wherein the first and second seal members each include a hook portion and a seal plate portion, the hook portion of the first seal member embracing the first flange portion so as to slide in the turbine radial direction along the first flange portion and the seal plate portion of the first seal member being inserted in the seal groove of the inner nozzle end wall when the first gap is sealed by the first seal member, and the hook portion of the second seal member embracing the second flange portion so as to slide in the turbine radial direction along the second flange portion, the seal plate portion of the second seal member being inserted in the seal groove of the outer nozzle end wall when the second gap is sealed by the second seal member,
wherein the seal groove and the seal plate portion are configured to include:
a first surface contact region at which a first portion of the high temperature-side inner wall surface of the seal groove of the inner nozzle end wall and the seal plate portion of the first seal member are in surface contact with each other when the first gap is sealed by the first seal member,
a first non-contact region disposed closer to the transition piece than the first surface contact region, the first non-contact region having a third gap interposed between a second portion of the high temperature-side inner wall surface of the inner nozzle end wall and the seal plate portion of the first seal member, and
a first through hole provided through the seal plate portion of the first seal member opposite the second portion of the high temperature-side inner wall of the seal groove of the inner nozzle end wall, and wherein
the seal groove of the outer nozzle end wall and the seal plate portion of the second seal member are configured to include:
a second surface contact region at which a first portion of the high temperature-side inner wall surface of the seal groove of the outer nozzle end wall and the seal plate portion of the second seal member are in surface contact with each other,
a second non-contact region disposed closer to the transition piece than the second surface contact region, the second non-contact region having a fourth gap interposed between a second portion of the high temperature-side inner wall surface of the outer nozzle end wall and the seal plate portion of the second seal member, and
a second through hole provided through the seal plate portion of the second seal member opposite the second portion of the high temperature-side inner wall surface of the seal groove of the outer nozzle end wall.

US Pat. No. 10,655,487

PRESSURE BALANCED SECONDARY SEAL

Raytheon Technologies Cor...

1. A gas turbine engine ring seal assembly, comprising:an annular stator seal support that extends radially between a radial inner support side and a radial outer support side;
an annular stator seal housing that extends radially between a radial inner housing side and a radial outer housing side, the seal housing includes an annular housing sleeve and a housing flange, where the housing sleeve is arranged at an inner housing side and extends axially between a first housing end and a second housing end and includes a first axially extending housing sleeve surface;
an annular stator seal element that includes a first stator seal axially extending surface radially adjacent to the first axially extending housing sleeve surface and a second stator seal axially extending surface;
a secondary seal that includes a axially extending distal radial surface that contacts the second stator seal axially extending surface, a proximate radial surface, a first radially extending secondary seal sidewall surface, a second radially extending secondary seal sidewall surface and a third radially extending secondary seal sidewall surface;
where the annular stator seal support includes a channel radially distal the radial inner support side, the channel includes a first radially extending channel sidewall and second radially extending channel sidewall located axially forward of the first radially extending channel sidewall, and a third radially extending channel sidewall located axially behind the first radially extending channel sidewall,
where the first radially extending secondary seal sidewall surface contacts the first radially extending channel sidewall, and the second radially extending channel sidewall is axially spaced from the second radially extending secondary seal sidewall surface that is radially closer to the second stator seal axially extending surface than the first radially extending secondary seal sidewall surface.

US Pat. No. 10,655,484

OPTIMIZED AERODYNAMIC PROFILE FOR A TURBINE VANE, IN PARTICULAR FOR A NOZZLE OF THE FOURTH STAGE OF A TURBINE

SAFRAN AIRCRAFT ENGINES, ...

1. A turbine vane presenting an aerodynamic profile, the aerodynamic profile defining the turbine vane when cold and in a non-coated state, the aerodynamic profile being substantially identical to a nominal aerodynamic profile determined by Cartesian coordinates X,Y,Zadim given in Table 1, in which coordinate Zadim is a quotient D/H, where D is a distance of a point under consideration from a reference X,Y plane situated at a base of the nominal aerodynamic profile, and H is a height of said aerodynamic profile measured from said reference X,Y plane out to an end of the turbine vane, the measurements D and H being taken radially relative to an axis of the turbine vane, while coordinate X is measured in an axial direction of the turbine vane.

US Pat. No. 10,655,477

TURBINE COMPONENTS AND METHOD FOR FORMING TURBINE COMPONENTS

GENERAL ELECTRIC COMPANY,...

14. A method for forming a turbine component, comprising:integrally forming a single, continuous tapered portion of an impingement wall by an additive manufacturing technique and incorporating the impingement wall into a manifold, the impingement wall including a wall thickness and defining a plenum, the tapered portion tapering to a wall inflection and including a plurality of impingement apertures; and
disposing the impingement wall within a component wall, the component wall including a plurality of external apertures and defining a constrained portion, the wall inflection being disposed proximal to the constrained portion,
wherein disposing the impingement wall within the component wall defines a post-impingement cavity between the manifold and the component wall, the post-impingement cavity being arranged to receive a fluid from the plenum through the plurality of impingement apertures and exhaust the fluid through the plurality of external apertures, the post-impingement cavity including an enervated zone disposed between the tapered portion and the constrained portion, and
wherein:
forming the single, continuous tapered portion includes forming the wall inflection having an inflection radius measured on the inside of the wall inflection of less than 3 times the wall thickness of the impingement wall at the wall inflection; or
forming the single, continuous tapered portion includes forming the tapered portion having a consolidated portion in which the impingement wall extends across the plenum between the plenum and the wall inflection such that the consolidated portion includes an effective wall thickness greater than the wall thickness of the impingement wall outside of the consolidated portion, the wall thickness and the effective wall thickness being measured from an interior surface of the impingement wall to an exterior surface of the impingement wall in a direction normal to the interior surface of the impingement wall, and the plurality of impingement apertures being disposed in the consolidated portion.

US Pat. No. 10,655,476

GAS TURBINE ENGINES WITH AIRFOILS HAVING IMPROVED DUST TOLERANCE

HONEYWELL INTERNATIONAL I...

1. An airfoil for a gas turbine engine, comprising:a first side wall;
a second side wall joined to the first side wall at a leading edge and a trailing edge, the first and second side walls extending in a radial outward direction from a base coupled to an airfoil platform; and
an internal cooling system arranged within the first and second side walls configured to direct cooling air through and out of the airfoil, the internal cooling system including a first cooling circuit comprising:
an acceleration channel generally extending in a radial outward direction and receiving cooling air from a first source, wherein at least a first section of the acceleration channel decreases in cross-sectional area along the radial outward direction such that the cooling air is accelerated through the first section of the acceleration channel, the acceleration channel defined in a radial outward direction by a forward radial internal wall that extends radially from a chordwise wall, with a portion of the chordwise wall having a curved surface to transition from the forward radial internal wall to a trailing edge chamber;
the trailing edge chamber fluidly coupled to receive at least a portion of the cooling air from the acceleration channel and extending generally in a chordwise aft direction from the acceleration channel to the trailing edge; and
an aft radial internal wall extending between the acceleration channel and the trailing edge chamber, the aft radial internal wall cooperating with the forward radial internal wall to define the acceleration channel, the aft radial internal wall defining crossover passages that fluidly couple the acceleration channel to the trailing edge chamber, the aft radial internal wall extending from a chordwise orientation at a first end to a radial orientation at a second end, the first end spaced apart from an end of the forward radial internal wall to define an inlet for the acceleration channel and the second end spaced apart from the chordwise wall to form a slot interface between the acceleration channel and the trailing edge chamber.

US Pat. No. 10,655,475

GAS TURBINE ENGINE TURBINE COOLING SYSTEM

ROLLS-ROYCE PLC, London ...

1. A gas turbine engine comprising a turbine and a turbine cooling arrangement, the turbine comprising a turbine rotor surrounded by a static rotor track liner comprising a single piece annular component, and a nozzle guide vane downstream of the turbine rotor in a core main gas flow path, the turbine cooling arrangement comprising:a first cooling air duct configured to provide a cooling airflow to a rotor track liner cooling plenum that directly impinges on the rotor track liner;
a second cooling air duct configured to provide a cooling airflow to the nozzle guide vane;
a common manifold provided upstream in the cooling airflow of the first and second ducts, and configured to provide cooling air to the first and second ducts; and
a two-way valve configured to modulate air provided to the first and second ducts from the manifold, the valve being configured to operate in one of a first mode and a second mode,
wherein when the valve is operated in the first mode, air flow to the first duct is relatively high and airflow to the second duct is relatively low compared to where the valve is operated in the second mode,
the rotor track liner has an inner surface which directly opposes a tip of the turbine rotor,
the cooling airflow exiting the first cooling air duct impinges on the rotor track liner directly from the first cooling air duct to the rotor track liner,
the rotor track liner cooling plenum includes a cooling air exhaust outlet disposed at a trailing edge of the rotor track liner with respect to a main core gas flow through the gas turbine engine, and
the cooling air exhaust outlet is in fluid communication with a cooling air inlet of the nozzle guide vane.

US Pat. No. 10,655,471

TURBINE AND GAS TURBINE

MITSUBISHI HITACHI POWER ...

1. A turbine comprising:a rotor which is capable of rotating about an axis extending in an axial direction; and
a plurality of blades attached to the rotor, wherein:
the plurality of blades are arranged in a circumferential direction with respect to the axis,
each of the plurality of blades has a blade main body extending radially outward with respect to the axis,
the blade main body includes a leading edge, a trailing edge, a hub endwall, and a tip,
the leading edge extends in a radial direction with respect to the axis, and is an end of the blade main body on a first radial side of the blade main body,
the trailing edge extends in a radial direction with respect to the axis, and is separated from the leading edge in the axial direction,
the hub endwall extends in the axial direction, and is a most radially inward portion of the blade main body with respect to the axis,
the tip extends in the axial direction, and is a most radially outward portion of the blade main body with respect to the axis,
in the blade main body, between the hub endwall and the tip, a position spaced from the hub endwall toward the tip is a reference blade height,
a flow path, through which a gas can flow, is formed between a first blade main body and a second blade main body, the first blade main body is the blade main body of a first blade of the plurality of blades, and the second blade main body is the blade main body of a second blade of the plurality of blades that is adjacent to the first blade in the circumferential direction,
a width of the flow path between the hub end wall of the first blade main body and the hub end wall of the second blade main body decreases toward a minimum width from the leading edge of the first main body, and increases toward the trailing edge of the first main body from the minimum width,
the width of the flow path at the reference blade height of the first blade main body and the second blade main body decreases toward the trailing edge of the first main body from the leading edge of the first blade main body,
a position of the minimum value of the width of the flow path between the first blade main body and the second blade main body undergoes a transition to the trailing edges from the hub endwall of the first blade main body toward the tip, and
the position of the minimum width of the flow path between the first blade main body and the second blade main body at the reference blade height is at the trailing edge of the first blade main body.

US Pat. No. 10,655,470

IMPELLER AND ROTARY MACHINE

MITSUBISHI HEAVY INDUSTRI...

1. An impeller comprising:an impeller body forming a disk-like shape and having a boss hole section formed therein, a rotating shaft being fitted into the boss hole section; and
a plurality of blades provided on a front surface side of the impeller body so as to protrude from a hub surface of the impeller body,
wherein the impeller is formed of a plurality of resin members, which are engaged with each other and made of a resin,
wherein the plurality of blades is formed only on one of the plurality of resin members,
wherein the plurality of resin members includes
a first resin member including the blades, and
a second resin member including the hub surface that has the boss hole section formed therein, the second resin member covering a base end part of each of the blades from an outer peripheral side, and allowing each of the blades to penetrate the second resin member from an inner peripheral surface of the boss hole section to the hub surface and to protrude from the hub surface in a radial direction of the rotating shaft.

US Pat. No. 10,655,466

METHOD OF MONITORING OF HYDRAULIC FRACTURE CLOSURE STRESS WITH TRACERS (VARIANTS)

Schlumberger Technology C...

1. A method of determining the fracture closure pressure in a formation penetrated by a wellbore, wherein:the wellbore is provided;
the clean fracturing fluid is injected into the wellbore, thus creating at least one fracture in the formation;
the fracturing fluid is injected into at least one well, wherein the fracturing fluid comprises a mixture of a proppant and one or more groups of capsules, which comprises one or more capsules with a predetermined range of breaking strengths and that comprise a marker agent, which corresponds to each predetermined range of breaking strength values;
wherein the capsules from different groups comprise different marker agents;
wherein the capsules are designed to settle in the fracture and release the marker agent when the fracture closure pressure exceeds the predetermined range of breaking strength values caused by the fracture closure;
the marker agent production to the surface is provided;
the marker agent is detected at the surface; and
the fracture closure pressure is determined according to the detected marker agent based on the range of breaking strength values of a capsule in the corresponding group of capsules.

US Pat. No. 10,655,464

DEVICE COMPRISING MULTIPLE DETECTORS FOR DETECTING A FLOW OF GAS EXTRACTED FROM A DRILLING FLUID

SCHLUMBERGER TECHNOLOGY C...

1. A device for analyzing at least a flow of gas extracted from a drilling fluid used for drilling a wellbore, comprising:a chassis having at least:
a power supply system
a fluid distribution and regulation system,
a control module,
at least a first and second analysis module of different types, each comprising at least a detector for measuring at least a parameter representative of a content of at least a gas compound in the flow of gas,
wherein the chassis comprises a core connector having power, communication and fluid outputs, each of the analysis modules having a module connector complementary to the core connector, wherein the complementary core and module connectors are configured to form a removable connection, and
wherein the device is configured to obtain a measurement from the detector of the first analysis module when the first analysis module is connected to the chassis via the core connector and to obtain a measurement from the detector of the second analysis module when the second analysis module is connected to the chassis via the core connector,
wherein the control module of the chassis is configured to control the power delivered to the core connector and/or the flow of gas delivered to the core connector in function of the type of the analysis module connected to the core connector.

US Pat. No. 10,655,462

ACOUSTIC TOOL ECCENTERING CORRECTION

SCHLUMBERGER TECHNOLOGY C...

1. A method comprising:transmitting an acoustic signal from a downhole tool positioned within a wellbore;
measuring amplitudes and travel times of the acoustic signal received at different azimuthal locations of the downhole tool;
determining correction factors, each corresponding to a different one of the measured amplitudes, based on the travel times measured at each of the different azimuthal locations; and
determining corrected amplitudes each based on the corresponding measured amplitude and the corresponding correction factor,
wherein determining the correction factors is further based on at least one of a plurality of acoustic-error-related (AER) variables, and wherein the AER variables include at least:
azimuthal separation between:
a transmitter of the downhole tool that transmits the acoustic signal; and
at least one of a plurality of receivers of the downhole tool, wherein the receivers are each disposed at a corresponding one of the different azimuthal locations and generate signals indicative of the measured amplitudes and arrival times;
axial separation between the transmitter and at least one of the receivers;
diameter of the wellbore;
inner diameter of a casing of the wellbore;
outer diameter of the casing;
radial thickness of the casing;
radial thickness of cement substantially surrounding the casing within the wellbore;
composition of drilling mud substantially surrounding the downhole tool within the casing;
density of the drilling mud;
acoustic slowness of the drilling mud.

US Pat. No. 10,655,459

TUBULAR DEVICE WITH RADIOFREQUENCY COMMUNICATION FOR WELL HEAD

BAKER HUGHES, A GE COMPAN...

1. An element for a drill string, comprising:a body with an axisymmetric appearance; and
a communication device installed in the body, wherein the communication device comprises:
a set of antennae including a plurality of antennae distributed at a periphery of the body, about an axis of symmetry thereof, and configured to operate in transmission and in reception;
operating electronics configured to organize transfer of data, in transmission and in reception, in packets, wherein a size of the packets is based on a rate of rotation of the body;
an actuator configured to selectively connect the antennae of the set to the operating electronics;
an antenna monitor configured to regularly evaluate a reception quality parameter for at least one sub-assembly of the set of antennae, to repetitively select one or more antennae of the set as a function of reception quality parameters derived from the sub-assembly, and to command the actuator to connect the selected antenna or antennae to the operating electronics.

US Pat. No. 10,655,454

SUBSEA WELL EQUIPMENT LANDING INDICATOR AND LOCKING INDICATOR

AKER SOLUTIONS AS, Lysak...

1. A subsea well equipment landing body (1) comprising an indicator assembly configured to indicate landing of the landing body (1) or to indicate locking of the landing body (1), the indicator assembly comprisinga stem bore (7);
a sliding stem (11) within the stem bore, with a stem head (23) protruding beyond an external face of the landing body;
a stem channel (25) in the sliding stem, extending between the stem head and a stem channel mouth (27), and in fluid communication with the outside of the landing body;
a hydraulic channel (9) in the landing body (1), in fluid communication with the stem bore (7);wherein the stem channel mouth is positionable ina communicating position, in which there is fluid communication between the hydraulic channel (9) and the stem channel (25); and
a non-communicating position, in which there is no fluid communication between the hydraulic channel (9) and the stem channel (25).

US Pat. No. 10,655,451

METHODS AND SYSTEMS EMPLOYING A GRADIENT SENSOR ARRANGEMENT FOR RANGING

Halliburton Energy Servic...

1. A system that comprises:a gradient sensor arrangement deployed in a first borehole, the gradient sensor arrangement having a plurality of spaced sensors, wherein the plurality of spaced sensors are disposed radially from a longitudinal axis of a downhole tool;
an electromagnetic (EM) transmitter deployed in a second borehole;
a processor configured to determine a distance or direction of the EM transmitter relative to the gradient sensor arrangement based on EM field measurements collected by the gradient sensor arrangement in response to an EM field emitted by the EM transmitter; and
a directional drilling controller configured to update a trajectory for either the first borehole or the second borehole in response to the determined distance or direction.

US Pat. No. 10,655,450

IFR1 SURVEY METHODOLOGY

CONOCOPHILLIPS COMPANY, ...

1. A method of directional drilling, the method comprising:obtaining a single set of in-field referencing (IFR) values for a planned well, the single set of IFR values captured by measuring local geomagnetic field data at a single location in a mid-lateral section of the planned well;
generating an improved magnetic model by combining the single set of IFR values with a global magnetic model;
obtaining downhole magnetic field data, the downhole magnetic field data captured along a borehole using surveying instrumentation, the borehole being drilled for the planned well; and
determining an orientation of the borehole based on the downhole magnetic field data and the improved magnetic model.

US Pat. No. 10,655,448

DOWNHOLE CEMENT STRAIN GAUGE

Halliburton Energy Servic...

13. A method, comprising:positioning a casing within the wellbore, the casing having a data collection tool coupled thereto;
positioning a sensor in cement within the casing, wherein the sensor comprises a substrate, a strain-sensitive element disposed separate from the substrate and a transceiver coupled to the substrate and configured to communicate with the data collection tool; and
injecting the cement into the casing such that the sensor becomes disposed in an annulus of the wellbore.

US Pat. No. 10,655,446

SYSTEMS, APPARATUSES, AND METHODS FOR DOWNHOLE WATER SEPARATION

Saudi Arabian Oil Company...

1. A method comprising:positioning a water separation apparatus within a wellbore formed in an oil reservoir formation, wherein the water separation apparatus comprises:
a tubular housing extending from an enclosed first longitudinal housing end to an enclosed second longitudinal housing end along a central axis and defining a housing inner surface of a tubular cavity;
an extractor tube arranged within the tubular housing and extending through the first longitudinal housing end, from a first open end proximal the first longitudinal housing end to a second open end within the tubular cavity; and
at least one aperture defined radially though the tubular housing and the housing inner surface, defined longitudinally at a location between the first longitudinal housing end and the second open end, and formed to create a hydrocyclonic flow about the tubular cavity when a liquid flows into the tubular cavity through the aperture;
receiving within the water separation apparatus and through a first channel defined by the at least one aperture, the first channel defining a first longitudinal channel axis parallel to a first tangent line tangential to the tubular, a fluid mixture that comprises liquid water and liquid hydrocarbon moving in a linear flow along the first longitudinal channel axis from the oil reservoir formation to the wellbore and into the tubular cavity;
contacting the housing inner surface with the fluid mixture;
redirecting, by the housing inner surface, the flow away from the central axis and into the hydrocyclonic flow about the housing inner surface;
separating, by the hydrocyclonic flow, the liquid water from the liquid hydrocarbon;
drawing the separated liquid hydrocarbon into the extractor tube
conveying the separated liquid hydrocarbon through the second open end of the extractor tube toward the first open end of the extractor tube and further to a surface end of the wellbore;
conveying the separated liquid water through the enclosed second longitudinal housing end of the tubular housing in a downhole direction;
flowing the separated liquid water through a one-way valve at a packer in the wellbore to a chamber at a lower portion of the wellbore;
disposing a hydraulic propeller in the chamber;
agitating, via a hydraulic propeller disposed in the chamber, the separated liquid water in the chamber to cause debris in the chamber to become suspended in the separated liquid water; and
pumping a suspension of the separated liquid water and the debris uphole toward the surface end of the wellbore from the chamber.

US Pat. No. 10,655,442

METHOD FOR WELLBORE STIMULATION OPTIMIZATION

Schlumberger Technology C...

1. A method of performing a stimulation operation at a wellsite, the wellsite positioned about a subterranean formation having a wellbore therethrough and zones therealong, the method comprising:establishing at least one objective for stimulating production of reservoir fluid from the subterranean formation and into the wellbore, wherein the at least one objective is based on wellsite data, and wherein the at least one objective comprises optimizing one or more skin parameters;
identifying at least one constraint for the stimulating;
determining target distributions of stimulating fluid based on the at least one objective and the at least one constraint;
selecting operational parameters for the stimulating based on the at least one constraint and the target distributions;
performing the stimulation operation in the wellbore by placing a stimulating fluid along the zones, wherein the stimulation operation comprises performing a matrix stimulation treatment, wherein performing the stimulation operation comprises determining an apparent skin effect in real time;
monitoring the wellsite while performing the stimulation operation, wherein monitoring the wellsite comprises evaluating an efficiency of the matrix stimulation treatment; and
adjusting the stimulating fluid based on the monitoring, wherein the stimulating comprises matrix acidizing.

US Pat. No. 10,655,439

GAS LIFT METHOD AND APPARATUS

Weatherford U.K. Limited,...

23. A gas lift valve to inject a lift gas from an annulus of a wellbore into a production string, the gas lift valve comprising:a valve inlet for communicating with the lift gas in the annulus and a valve outlet for communicating with a production string;
a variable orifice positioned between the valve inlet and valve outlet; and
a controller configured to receive data associated with production pressure and control the variable orifice in accordance with said production pressure to control an injection flow rate of the lift gas from the annulus into the production string,
wherein the controller is configured to:
operate the variable orifice gas lift valve in a learning mode of operation to determine a setting of the variable orifice gas lift valve which provides a target production pressure or pressure condition, the pressure condition comprising a substantially minimum production pressure; and
operate the variable orifice gas lift valve in a subsequent operational mode of operation in which the variable orifice gas lift valve is set at a position previously determined during the learning mode of operation; and
wherein to determine the setting of the gas lift valve in the learning mode of operation, the controller is configured to at least one of:
determine the production pressure with the gas lift valve set at multiple positions, and then select the setting of the gas lift valve which provides the target production pressure or pressure condition; and
set the gas lift valve at different incremental positions between a fully closed state and a fully open state, and determine the valve position which provides a lowest or minimized production pressure.

US Pat. No. 10,655,437

BUOYANT SYSTEM AND METHOD WITH BUOYANT EXTENSION AND GUIDE TUBE

TECHNIP FRANCE, Courbevo...

1. A buoyant system configured to be detachable from an offshore floating platform, comprising:a buoyant extension having a buoyancy and configured to be detachably coupled with the offshore floating platform; and
a first guide tube coupled to the buoyant extension and configured to allow a rigid portion of a riser to pass through the guide tube alternatively between a first elevation below the offshore floating platform and a higher second elevation at the offshore floating platform and allow the rigid portion of the riser to descend to the first elevation below the offshore floating platform while sliding through the first guide tube on the buoyant extension.

US Pat. No. 10,655,435

SMART FRACTURING SYSTEM AND METHOD

U.S. Well Services, LLC, ...

13. A hydraulic fracturing method, comprising:performing one or more hydraulic fracturing operations at a hydraulic fracturing system, the hydraulic fracturing system comprising a plurality of pumps, a distribution system, and a wellhead;
measuring one or more operational parameters of the plurality of pumps, the distribution system, or the wellhead;
transmitting a first parameter of the one or more operational parameters from a first device of the plurality of pumps, the distribution system, or the wellhead to a second device of the plurality of the plurality of pumps, the distribution system, or the wellhead;
detecting that the first parameter is outside of an acceptable threshold;
generating automated instructions at the second device based at least in part on the first parameter; and
automatically adjusting one or more functions of the second device based on the automated instructions.

US Pat. No. 10,655,432

SELF-CLEANING SAND SCREEN

ENERCORP SAND SOLUTIONS I...

15. A method of removing sand from a screen disposed in a pressure vessel, the method comprising:causing a well fluid to flow into the pressure vessel, wherein the screen in the pressure vessel removes the sand from the well fluid, and wherein at least a portion of the sand that is removed from the well fluid at least partially obstructs one or more openings in the screen;
removing the sand from the screen using a cleaning assembly that is positioned at least partially between the pressure vessel and the screen;
rotating the screen about a central longitudinal axis that extends therethrough as the sand is removed from the screen, wherein rotating the screen comprises powering a power device positioned in the pressure vessel, such that the power device rotates the screen; and
moving the cleaning assembly, using a linear actuator positioned in the pressure vessel and adjacent to the power device, in a linear direction that is parallel to the central longitudinal axis of the screen.

US Pat. No. 10,655,429

THRU-TUBING RETRIEVABLE INTELLIGENT COMPLETION SYSTEM

Saudi Arabian Oil Company...

16. A method of completing a target zone of a wellbore of a well, the method comprising:passing a sub-surface completion unit (SCU) through production tubing disposed in a wellbore of a well;
passing the SCU though the wellbore of the well to a target zone of an open-holed portion of the wellbore;
deploying one or more SCU centralizers of the SCU to position the SCU in the target zone of the open-hole portion of the wellbore; and
deploying one or more SCU anchoring seals of the SCU to seal against a wall of the target zone of the open-hole portion of the wellbore to provide zonal isolation between regions in the wellbore, wherein at least one of the one or more SCU anchoring seals is non-retrievable; and
inflating the at least one of the one or more SCU anchoring seals that is non-retrievable with a hardening substance and detaching the at least one of the one or more SCU anchoring seals that is non-retrievable and inflated with a hardening substance from a body of the SCU and removing the body of the SCU from the target zone such that the at least one of the one or more SCU anchoring seals that is detachable and inflated with a hardening substance remain in the target zone.

US Pat. No. 10,655,428

FLOW CONTROL DEVICE

Weatherford Technology Ho...

1. A flow control apparatus, comprising:a housing having a bore extending and a port formed through a wall of the housing;
a port sleeve disposed in the housing and having a port in communication with the port of the housing;
a first sleeve releasably attached to the housing, wherein the first sleeve is movable from a first position preventing axial movement of the port sleeve relative to the housing to a second position allowing axial movement of the port sleeve relative to the housing; and
a second sleeve releasably attached to the port sleeve, wherein the second sleeve is movable from a first position blocking fluid communication through the port of housing and the port of the port sleeve to a second position allowing fluid communication through the ports.

US Pat. No. 10,655,418

SUBSEA LANDING STRING WITH AUTONOMOUS EMERGENCY SHUT-IN AND DISCONNECT

SCHLUMBERGER TECHNOLOGY C...

1. A system for use in a subsea well, comprising:a blowout preventer;
a landing string received in the blowout preventer, the landing string comprising a plurality of valves, a selective disconnect latch assembly, and a landing string instrumentation module, the latch assembly in a housing that selectively favors breaking induced by a vertical load over breaking due to non-vertical bending loads, the housing accommodating a weakened region of tailored susceptibility to breaking when a predetermined vertical load is applied thereto; and
a control system working in cooperation with the landing string instrumentation module to autonomously disconnect the landing string at the latch assembly and to block fluid flow above and below the latch assembly via closure of the plurality of valves upon the occurrence of a predetermined condition detected by the landing string instrumentation module.

US Pat. No. 10,655,413

DESTRUCTION MECHANISM FOR A DISSOLVABLE SEALING DEVICE

TCO AS, Tyssedal (NO)

1. A destruction mechanism for supporting and crushing a sealing device, wherein the sealing device comprises one or more glass layers positionable in a wellbore, the destruction mechanism comprising:an axially displaceable glass supporting sleeve arranged to support the one or more glass layers by a hydraulic fluid locked in a support chamber;
a relief chamber in communication with the support chamber;
a crusher device arranged to crush the one or more glass layers; and
wherein the glass supporting sleeve is arranged to be axially displaced together with the one or more glass layers when the hydraulic fluid is released from the support chamber into the relief chamber and where the crusher device is arranged to destruct the one or more glass layers.

US Pat. No. 10,655,412

ELECTRO-HYDRAULIC COMPLEX WITH A PLASMA DISCHARGER

ILMASONIC-SCIENCE LIMITED...

1. An electrohydraulic complex with a plasma discharger comprising a surface power supply and control unit, a downhole electrohydraulic device, electrodes, a metal wire feeding unit, characterized in thatthe downhole electrohydraulic device has a modular structure and consists of a boosting inverter unit, at least one block of capacitors and the plasma discharger,
wherein the plasma discharger consists of a housing with an internal cavity, with an upper part of the housing being connected to a coupling bushing, and a lower part of the housing being connected to a bearing sleeve;
the housing internal cavity contains a cylinder mounted on a middle part of the bearing sleeve, and the cylinder has a piston with a rod and a return spring;
the wire feeding unit is made in a form of a lever with a support platform and a wing with a spring, said wire feeding unit is mounted on an upper part of the piston, and directional notches are made on the support platform and on the wing on a side facing a wire;
four support rods are attached to the cylinder, which form an attaching unit of a coil;
holes are made in the bearing sleeve for fixation of positive and negative electrodes, said electrodes being insulated except for open areas configured for providing a plasma discharge;
an axial hole for the wire is made in the negative electrode;
a guide cone is mounted at a bottom of the bearing sleeve by means of racks;
the piston is made with at least one hole that equalizes pressure of a head-end volume and a well pressure.

US Pat. No. 10,655,411

DEGRADABLE, FRANGIBLE COMPONENTS OF DOWNHOLE TOOLS

Halliburton Energy Servic...

1. A method comprising:introducing a wellbore tool into a wellbore penetrating a subterranean formation, the wellbore tool comprising a frangible, degradable component, wherein the frangible, degradable component comprises, a degradable metal alloy selected from the group consisting of a magnesium alloy, an aluminum alloy, and any combination thereof; wherein the frangible, degradable component is a first frangible, degradable component and the wellbore tool further comprises a second frangible,degradable component, wherein the first frangible, degradable component and the second frangible, degradable component each compromise dissimilar metals that generate a galvanic coupling, wherein the first frangible, degradable component and the second frangible, degradable component are mechanically coupled with one another;
applying a shear stress to at least one of the first or second frangible, degradable component sufficient to break the frangible, degradable component, thereby producing pieces of the frangible, degradable component;
contacting the degradable metal alloy with an electrolyte; and
at least partially degrading the degradable metal alloy.

US Pat. No. 10,655,410

DUAL GRADIENT DRILLING SYSTEM AND METHOD

AMERIFORCE GROUP INC., H...

1. A dual gradient drilling system comprising:a subsea blowout preventer disposed above a wellhead, the subsea blowout preventer comprising a central lumen configured to provide access to a wellbore;
a lower section of a marine riser fluidly connected to the subsea blowout preventer;
a closed-hydraulic positive displacement subsea pump system fluidly connected to the lower section of the marine riser and disposed at a subsea depth from shallow to mid-riser depth or equivalent;
an independent mud return line fluidly connecting one or more pump heads of the closed-hydraulic positive displacement subsea pump system to a floating platform of a rig without use of an additional pump system; and
an annular sealing system disposed above the closed-hydraulic positive displacement subsea pump system,
wherein a pump speed of the closed-hydraulic positive displacement subsea pump system is adjusted to achieve a target amount of fluid mass in a fluidly connected system upstream of the closed-hydraulic positive displacement subsea pump to achieve a target inlet pressure of the closed-hydraulic positive displacement subsea pump.

US Pat. No. 10,655,409

SENSOR OPTIMIZATION FOR MUD CIRCULATION SYSTEMS

Halliburton Energy Servic...

1. A method comprising:circulating a mud through a mud circulation system that includes a plurality of sensors that include at least one of: a pressure sensor, a stroke counter, a flow sensor, a viscosity sensor, or density sensor; and
modeling the plurality of sensors using a state reduction approach adopted on a covariance matrix to extract one or more states of the mud circulation system corresponding to at least one selected from the group consisting of preferred locations, preferred sensory types, preferred sensor frequency resolution, and a combination thereof; and
providing a preferred sensor scheme for the mud circulation system based on the modeling of the plurality of sensors.

US Pat. No. 10,655,407

TUBULAR DELIVERY ARM FOR A DRILLING RIG

Schlumberger Technology C...

1. A tubular delivery arm (500) for a drilling rig (1), comprising:a dolly (510) vertically translatably connected to a mast (10) of the drilling rig (1);
an arm (532) rotatably and pivotally connected to the dolly (510) at its upper end;
a tubular clasp (550) pivotally connected to the arm (532) at its lower end, wherein the tubular delivery arm (500) is translatable along the mast (10) in non-conflicting passage of a top drive (200) connected to the same mast (10);
a grease dispenser extendably connected to a lower end of the arm; and
a grease supply line connected between the grease dispenser and a grease reservoir, wherein extension of the grease dispenser positions the grease dispenser at least partially inside of a box connection of a tubular stand secured by the tubular clasp, and wherein the grease dispenser delivers grease to an interior of the box connection.

US Pat. No. 10,655,406

HORIZONTAL CONNECTION SYSTEM FOR SUBSEA HUB CONNECTIONS

VETCO GRAY SCANDINAVIA AS...

1. A horizontal connection system for subsea connection of a first hub arranged at an end of a first tubular member to a second hub arranged at an end of a second tubular member, the horizontal connection system comprising:a first holding unit, wherein the first hub is fixed to the first holding unit;
a second holding unit, wherein the second hub is fixed to the second holding unit;
a clamp connector for connecting and securing the first hub to the second hub, the clamp connector being secured to the first holding unit; and
a heat bank for thermally insulating the clamp connector from ambient cold sea water, the heat bank comprising a casing which encloses an internal fluid chamber, wherein the fluid chamber is configured to accommodate a fluid having heat-storing capacity, and wherein the clamp connector is to be received in the fluid chamber with the fluid surrounding the clamp connector, the casing comprising a rear part which is secured to the first holding unit and a front part which is releasably connectable to the rear part,
wherein:
the front part of the casing is configured to be temporarily fixed to the rear part of the casing by connecting members extending between the front part and the rear part on the outside thereof;
the front part of the casing is provided with fastening members which are configured to come into engagement with associated fastening members on the second holding unit, to thereby allow the front part to be secured to the second holding unit, when the front part and the second holding unit are brought into contact with each other by an axial movement of the front part towards the second holding unit together with the rear part of the casing and the first holding unit or by an axial movement of the second holding unit towards the front part of the casing; and
the fastening members on the front part of the casing snap into locking engagement with the associated fastening members on the second holding unit when the front part and the second holding unit are brought into contact with each other.

US Pat. No. 10,655,405

METHOD AND APPARATUS FOR OPTIMIZING A WELL DRILLING OPERATION

Sun Energy Services, LLC,...

1. For completion of a non-conventional well, with perforated well casings in place within the wellbore and frac plugs separating segments of the well casing, a method of optimizing clean out of residual materials from the well casings to allow gas to flow from the well comprising the steps of:A) inserting a tubular string within an actual well casing and monitoring in real time actual tripping speed, actual string rotation speed, and actual surface torque imparted to the tubular string at a particular string depth;
B) for the given tubular string and for a predefined clean well casing based upon the actual well casing using mathematical modeling of the predefined clean well casing and a friction factor, generating a calculated value of surface torque at the particular string depth, the actual tripping speed, and at the actual rotation speed of the tubular string;
C) comparing an actual value of surface torque at the particular string depth to the calculated value of surface torque for the predefined clean well casing and a friction factor over a range of string depths; and
D) when the actual values of surface torque exceed the calculated values of surface torque for the predefined clean well casing and a friction factor over the range of string depths by a predetermined amount, then circulating the well to clean out the residual material.

US Pat. No. 10,655,402

ONE-CONNECTOR PENETRATOR SYSTEM ADAPTABLE TO ANY CABLES USED IN ARTIFICIAL LIFT SYSTEM

SCK Hydraulic Energy and ...

1. A one-connector penetrator system comprisingan enclosure having a hollowed interior; and
a plurality of seals housed within said enclosure, said plurality of seals capable of stabilizing a three-phase power cable in a fixed position, wherein said plurality of seals comprises
a first seal placed at a front-end portion of said enclosure;
a second seal placed within a middle portion of said enclosure; and
a third seal placed at a bottom portion of said enclosure;
further wherein said enclosure comprises
a penetrating mandrel at the top portion of said enclosure, the front-end portion of said penetrating mandrel houses a portion of said first seal;
a conic cone at the rear end portion of said enclosure, wherein said conic cone receives said three-phase power cable;
a crossover adapter that connects said penetrating mandrel with said conic cone;
a mandrel crossover that connects said penetrating mandrel with said crossover adapter, further wherein said second seal is placed within the interior walls of said mandrel crossover; and
a conic insurance adapter that connects said mandrel crossover, said crossover adapter and said conic cone together, further wherein said third seal is placed within the interior walls of said conic insurance adapter.

US Pat. No. 10,655,399

MAGNETIC POSITIONING OF REINFORCING PARTICLES WHEN FORMING METAL MATRIX COMPOSITES

Halliburton Energy Servic...

1. A method comprising:placing reinforcement materials within an infiltration chamber of a mold assembly, the reinforcement materials comprising magnetic reinforcing particles and non-magnetic reinforcing particles;
positioning one or more magnetic members relative to the mold assembly to selectively locate the magnetic reinforcing particles within the infiltration chamber with respect to the non-magnetic reinforcing particles; and
infiltrating the reinforcement materials with a binder material to form a hard composite after selectively locating the magnetic reinforcing particles within the infiltration chamber.

US Pat. No. 10,655,398

ATTACHMENT OF TSP DIAMOND RING USING BRAZING AND MECHANICAL LOCKING

Halliburton Energy Servic...

1. A polycrystalline diamond cutter for use in a drill bit, comprising:a substrate;
a non-leached polycrystalline diamond (PCD) table bonded to the substrate;
a leached polycrystalline diamond (PCD) table brazed to both the substrate and the non-leached PCD table and defining a cutting edge of the polycrystalline diamond cutter;
a first braze alloy located between the leached PCD table and the substrate; and
a second different braze alloy located between the leached PCD table and the non-leached PCD table.

US Pat. No. 10,655,397

MECHANICAL-INTERLOCKING REINFORCING PARTICLES FOR USE IN METAL MATRIX COMPOSITE TOOLS

Halliburton Energy Servic...

1. A metal matrix composite (MMC) tool for use in a wellbore, comprising:a bit body capable of being used in a wellbore, having a hard composite portion that includes reinforcing particles dispersed in a binder material, wherein at least some of the reinforcing particles comprise a monolithic particle structure including a core having irregular outer surface features integral with the core, the irregular outer surface features interlocked with neighboring reinforcing particles.

US Pat. No. 10,655,385

DUAL CORD OPERATING SYSTEM FOR AN ARCHITECTURAL COVERING

HUNTER DOUGLAS INC., Pea...

1. A covering for an architectural structure or feature, said covering comprising:a head rail;
a covering material depending from said head rail; and
an operating system comprising:
a first drive assembly operable to move said covering material between an extended configuration and a retracted configuration, said first drive assembly including a first pulley and a second pulley coupled to and driven by said first pulley; and
a second drive assembly including an operating wand having a longitudinal axis, said operating wand operable to move said covering material between a closed configuration and an open configuration;
wherein:
said first drive assembly comprises a cord loop including a first segment and a second segment, said first segment of said cord loop, said second segment of said cord loop, and said wand are all aligned with one another with said first segment of said cord loop positioned on a first side of said longitudinal axis of said operating wand and said second segment of said cord loop is positioned on a second, opposite side of said longitudinal axis of said operating wand; and
said first pulley including a longitudinal axis of rotation, said longitudinal axis of rotation of said first pulley is angled relative to a longitudinal axis of said operating wand.

US Pat. No. 10,655,379

OPENING AND CLOSING SYSTEM

MITSUI KINZOKU ACT CORPOR...

1. An opening and closing system, comprising:a drive unit configured to drive a closing openable member to be opened or closed, the closing openable member being provided in an opening portion of a vehicle;
an opening and closing control unit configured to control the drive unit to open or close the closing openable member;
an image capturing unit comprising a camera disposed on the closing opening member, the image capturing unit configured to capture an image of a periphery of the closing openable member;
a detecting unit configured to detect an obstacle proximate to the closing openable member based on the image captured by the image capturing unit, wherein the detecting comprises extracting an image from the captured image through image analysis and calculating a direction of and a distance to the obstacle relative to the image capturing unit; and
an identifying unit configured to identify whether the obstacle detected by the detecting unit is a human body,
wherein the opening and closing control unit is further configured to:
in response to the obstacle being detected by the detecting unit, control the identifying unit to identify whether the obstacle detected by the detecting unit is the human body;
in response to the detected obstacle being identified as the human body, stop the closing openable member before the closing openable member comes into contact with the obstacle; and
in response to the detected obstacle being identified as not the human body, move the closing openable member outwards by a predetermined angle.

US Pat. No. 10,655,355

DEVICE FOR FORMING POST SLEEVES AND RELATED METHODS

1. A method of forming a post sleeve to support a post in the ground, the method comprising:releasing a first portion of an end cap from a post sleeve cap, wherein a post sleeve sock is coupled to the first portion of the end cap;
releasing a second portion of the end cap from the post sleeve cap;
coupling the first portion of the end cap to the second portion of the end cap to form the end cap;
unfolding the post sleeve sock from within a post cavity of the post sleeve cap that is configured to form an upper portion of the post sleeve, the post sleeve sock being coupled to the post sleeve cap over a lower end of the post cavity;
inserting the post through the post sleeve cap and through the post sleeve sock;
positioning the post, the post sleeve sock and the post sleeve cap within a post hole in the ground;
filling the post hole with uncured concrete so the uncured concrete surrounds at least a portion of the post sleeve cap and at least a portion of the post sleeve sock that surrounds the post; and
allowing the uncured concrete to cure.

US Pat. No. 10,655,354

CUSTOM NUT SYSTEM AND METHOD OF ADAPTING NON-CONFORMING TOWER BASE

Sabre Communications Corp...

1. A method for anchoring a utility pole, comprising:measuring deviations in anchor thread dimensions from a standard anchor thread dimension in anchor posts protruding from a ground fixture;
selecting a number of anchor nuts from a set of non-standard thread dimensioned anchor nuts to correspond to the deviations in anchor thread dimensions; and
securing the utility pole to the ground fixture with the selected non-standard thread dimensioned anchor nuts.

US Pat. No. 10,655,347

CONCRETE FORMING SYSTEM

TGR Construction, Inc., ...

1. A concrete forming system, comprising:a first wall having a first end, a second end, an upper end and a lower end;
a second wall having a first end, a second end, an upper end and a lower end;
a cavity defined between the first wall and the second wall, wherein the cavity is adapted to receive a volume of concrete;
an opening formed within the upper ends of the first wall and second wall, wherein the opening is fluidly connected with the cavity, wherein the opening is adapted to receive the concrete; and
a first vehicle adapted to traverse a ground surface, wherein the first vehicle includes:
a first arm extending from the first vehicle, wherein the first arm retains the first wall in a desired position with respect to the second wall;
a first arm coupler connected between the first arm and the first wall;
a plurality of first wheels or a plurality of first tracks connected to a first motor; and
a first actuator connected between the first arm and the first arm coupler, wherein the first actuator is adapted to adjust the first wall with respect to the first arm.

US Pat. No. 10,655,342

WATER RESISTANT FLOORING UNDERLAYMENT

Maxxon Corporation, Hame...

1. A method of installing a flooring structure, the method comprising the steps of:providing an acoustic insulating layer over a sub-floor layer; and
providing an underlayment layer over the acoustic insulating layer, the underlayment layer comprising gypsum concrete including a mixture of alpha calcium sulfate hemihydrate and beta calcium sulfate hemihydrate and having a water-resistant, silane-based additive, wherein the underlayment layer comprises the gypsum concrete including the mixture of alpha calcium sulfate hemihydrate and beta calcium sulfate hemihydrate as between 90% and 95% by weight of the underlayment layer prior to providing the underlayment layer over the acoustic insulating layer, and wherein the water-resistant, silane-based additive comprises between 0.4% and 9% by weight of the underlayment layer prior to providing the underlayment layer over the acoustic insulating layer,
wherein the provided underlayment layer is adapted to directly receive a finished floor layer without a primer or sealer coat applied to the underlayment layer.

US Pat. No. 10,655,325

METHOD FOR MANUFACTURING A BALLAST MASS

SOLETANCHE FREYSSINET, R...

1. A method of producing a ballast weight for damping vibrations of a structure, the structure having a low point and a high point, the ballast weight comprised of ballast components including at least part of a ballast cable, the ballast cable having successive portions, the method comprising:connecting the ballast cable to a conveying device,
by means of the conveying device, moving successive portions of the ballast cable from the low point to the high point, and
forming the ballast weight from at least part of the successive portions of the ballast cable which have been conveyed to the high point.

US Pat. No. 10,655,319

DRAIN AUGER ENCASEMENT AND DRAIN AUGER INCLUDING THE SAME

19. An encasement for a drain auger, comprising:a chamber configured to receive the drain auger; and
an opening configured to permit insertion of the drain auger into the chamber,
wherein the chamber has at least one sloped wall configured to receive the drain auger and maintain the drain auger in an upright position,
wherein the at least one sloped wall defines an external cavity; and
wherein the at least one sloped wall further defines an exposed bottom platform under the external cavity.

US Pat. No. 10,655,318

STORMWATER DRAIN BAFFLE

UPONOR INFRA OY, Vantaa ...

1. A stormwater drain baffle to be disposed in a flow-through stormwater sump or chamber for baffling a stormwater flow-path, the baffle comprising:a first baffle portion and a second baffle portion, each of the first baffle portion and the second baffle portion including a plurality of openings;
the first and second baffle portions configured to be connected to each other, wherein the first and second baffle portions are disposed near to and in superposed relation to each other so that the first and second baffle portions overlap each other and are adjustably connected to each other for adjusting the width (Wtot) of the baffle;
wherein the first and second baffle portions of the baffle include a fixing member adapted for fixing the baffle to the inner sidewall of the sump or the chamber; and
wherein the first baffle portion has a first pair of horizontal stiffening members and the second baffle portion has a second pair of horizontal stiffening members, the distance between the first pair of stiffening members of the first baffle portion having a first dimension and the distance between the second pair of stiffening members of the second baffle portion having a second dimension, the first dimension being less than the second dimension.

US Pat. No. 10,655,313

GREY WATER TOILET

KOHLER CO., Kohler, WI (...

13. A grey water toilet configured to be in fluid communication with a drain pipe, the toilet comprising:a first compartment configured to hold a volume of fresh water;
a second compartment configured to hold a volume of grey water and fluidly separated from the first compartment to prohibit commingling between the fresh water and the grey water;
a pedestal configured to support the first and second compartments, the pedestal comprising:
a bowl having an inlet that is in fluid communication with the first compartment, such that the bowl is configured to receive fresh water; and
a passage having a first end in fluid communication with an outlet of the bowl, a second end configured to be in fluid communication with the drain pipe, a bottom surface defining an upper peak, and an inlet opening provided between the first end and the second end; and
a valve disposed between the inlet opening of the passage and an outlet of the second compartment;
wherein the passage is configured to receive grey water from the second compartment through the inlet opening during a flush cycle; and
wherein the inlet opening is provided at a location that is level with or below the upper peak.

US Pat. No. 10,655,312

AUTOMATIC TOILET PLUNGER

1. An automatic toilet plunger device comprising:a plunger body, the plunger body having a top end, a bottom end, and an inside, the plunger body being hollow and cylindrical;
a plunger head coupled to the plunger body, the plunger head being coupled to the bottom end of the plunger body;
a plunging actuator coupled to the plunger, the plunging actuator being coupled within the inside of the plunger body, the plunging actuator being in operational connection with the plunger head such that the plunging actuator is configured to cause the plunger head to clear a toilet when the plunger actuator is manipulated;
a plurality of controls coupled to the plunger body, the plurality of controls being in operational communication with the plunging means;
a power source coupled to the plunger body, the power source being in operational communication with, and providing power to, the plunging actuator; and
a pair of adjustable mounting arms coupled to the plunger body, the pair of adjustable mounting arms being configured to engage with a rim of the toilet.

US Pat. No. 10,655,308

MODULAR, ADAPTABLE AND EXPANDABLE BOOSTER PUMP SYSTEM

IDAC CORPORATION, Stroud...

1. A booster pump system for a piping system of the type having a suction manifold with a closed end section and a discharge manifold with a closed end section, said booster pump system comprising: a first pump module and a second pump module; said first pump module comprising at least a first suction manifold section having a first end with a connector and a second end with a connector, at least a first discharge manifold section having a first end with a connector and second end with a connector, and first and second pumps connected in parallel between said first suction manifold section and said first discharge manifold section; said a second pump module comprising at least a second suction manifold section having a first end with a connector and a second end with a connector, at least a second discharge manifold section having a first end with a connector and second end with a connector, and at least one pump connected between said second suction manifold section and said second discharge manifold section, wherein each of said ends of said first suction manifold section configured to be connected to one of said ends of said second suction manifold section or to the closed end section of the suction manifold, and each of said ends of said first discharge manifold section configured to be connected to one said ends of said second discharge manifold section or to the closed end section of the discharge manifold.

US Pat. No. 10,655,307

LOCK FOR A WEAR ASSEMBLY

ECSO Group LLC, Portland...

1. A wear member for ground-engaging equipment comprisinga wearable body having an internal surface facing a base on the equipment and an opposite external surface,
a hole extending from the external surface to the internal surface, and
a lock integrally mounted in the hole for movement between a locked position where the lock contacts the base to hold the wear member to the ground-engaging equipment and a release position where the lock releases the base, the lock having
a lock body having a bearing surface to releasably engage the base and a coupling structure to engage the wearable body,
a latch member movable relative to the lock body between a first position to engage the wearable body to hold the lock alternatively in the locked position and the release position, and a second position retracted from the first position, and an actuating member operative to move the latch member from the first position to the second position, and move the lock body relative to the wearable body.

US Pat. No. 10,655,301

AUTOMATED CONTROL OF DIPPER SWING FOR A SHOVEL

Joy Global Surface Mining...

1. A method of compensating swing control of a dipper of a shovel, the shovel including a swing motor, the method comprising:determining, by at least one processor, a current swing direction of the dipper;
determining, by the at least one processor, a direction of compensation opposite the current swing direction of the dipper;
monitoring, by the at least one processor, an acceleration of the dipper;
detecting, by the at least one processor, an impact of the dipper with an object when the monitored acceleration is within a determined range of acceleration values;
modifying, by the at least one processor, a swing torque value for the swing motor; and
applying, by the at least one processor, the modified swing torque value for the swing motor to slow a current swing speed of the dipper in response to detecting the impact of the dipper with the object.

US Pat. No. 10,655,259

QUILT STAMPS

1. A quilt stamp comprising:a transparent material having outer edges defining a shape, a stamping side and an adhering side opposite the stamping side, the adhering side forming an adhesive surface to enable the quilt stamp to be selectively adhered to a stamping block;
wherein the stamping side includes an outer ridge that extends along the outer edges and an inner ridge that is inwardly offset from and extends along the outer ridge.

US Pat. No. 10,655,249

CONTINUOUS MANUFACTURING SYSTEM FOR FIBER COMPONENTS

Amazon Technologies, Inc....

1. A method, comprising:weaving a fiber around a plurality of sections of an inner core from a first end to a second end of the inner core;
applying, using at least one of the inner core or a plurality of outer dies, pressure to the fiber around each of the plurality of sections in sequence from the first end to the second end; and
curing the fiber around each of the plurality of sections in sequence from the first end to the second end;
wherein each of the plurality of outer dies is formed to correspond to a respective section of the plurality of sections of the inner core.

US Pat. No. 10,655,244

GAN SUBSTRATE, METHOD FOR PRODUCING GAN SUBSTRATE, METHOD FOR PRODUCING GAN CRYSTAL, AND METHOD FOR MANUFACTURING SEMICONDUCTOR DEVICE

MITSUBISHI CHEMICAL CORPO...

1. A GaN substrate, comprising:a first main surface; and
a second main surface provided on an opposite side from the first main surface, wherein
an angle between a normal line of the first main surface and an m-axis is 0° to 20°, and
when the first main surface is divided into an outer peripheral portion measuring 3 mm or less from an edge and a central portion surrounded by the outer peripheral portion, and the central portion is divided into a plurality of square partitions each having a 5 mm side, at least one square region, which has a 100 ?m side and in which no dark spots are detected in a CL measurement, is observed within each of the partitions.

US Pat. No. 10,655,242

GROWING APPARATUS AND SINGLE-CRYSTAL INGOT GROWING METHOD USING THE SAME

SK SILTRON CO., LTD., Gu...

1. A single-crystal ingot growing method comprising:setting a location of an MGP (maximum gauss position) of a magnetic field such that the MGP is located above a surface of a melt;
setting a difference in intensity of the magnetic field between a center point of the melt and an edge point of the melt based on the set location of the MGP;
setting an intensity of the magnetic field that is applied to the melt based on the set difference in intensity of the magnetic field; and
growing a single-crystal ingot based on the set location of the MGP and the set intensity of the magnetic field,
wherein, in order to set a difference between a maximum value of an oxygen concentration and a minimum value of the oxygen concentration at an edge of a wafer manufactured using the grown single-crystal ingot to be less than 0.15 ppma, the magnetic field is a horizontal magnetic field, the MGP is located so as to be spaced apart from the surface of the melt by a distance ranging from +50 mm to +150 mm, and the difference in intensity of the magnetic field ranges from 420G to 500G.

US Pat. No. 10,655,241

ELECTRODE FOIL PRODUCTION METHOD AND CAPACITOR PRODUCTION METHOD

PANASONIC INTELLECTUAL PR...

1. A method for producing an electrode foil a capacitor, the method comprising:a first step of preparing the electrode foil produced by etching a part of a metal foil containing first metal by applying current between the metal foil and an electrode in etching liquid while a principal surface of the metal foil faces the electrode; and
a second step of forming a dielectric layer on the principal surface of the electrode foil, the principal surface being etched, and then causing the dielectric layer to contact with electrolyte, wherein:
in the first step, a masking member is disposed between the principal surface of the metal foil and the electrode so as to cover a partial region of the principal surface,
the masking member is an electric conductor, and
the masking member is electrically connected with the metal foil.

US Pat. No. 10,655,240

REMOVING BUBBLES FROM PLATING CELLS

LAM RESEARCH CORPORATION,...

1. An electroplating apparatus comprising:a chamber including an electrode arranged horizontally along a bottom portion of the chamber and an ionically resistive element with through holes arranged horizontally along a top portion of the chamber;
a membrane supported by a frame arranged between the electrode and the ionically resistive element;
one or more panels extending vertically and parallelly from the membrane to the ionically resistive element and extending linearly across the chamber, forming a plurality of regions between the membrane and the ionically resistive element;
a substrate holder arranged above the ionically resistive element to hold a first substrate with a treatable surface parallel to and facing the ionically resistive element;
a seal arranged between peripheries of the ionically resistive element and the substrate holder to prevent leakage of an electrolyte flowed laterally through a manifold between the treatable surface of the first substrate and a top surface of the ionically resistive element during electroplating, portions of the electrolyte descending from the manifold into the plurality of regions and ascending from the plurality of regions into the manifold via the through holes, forming air bubbles under the ionically resistive element and in a plurality of the through holes; and
a controller configured to:
place, in the substrate holder, a second substrate with a protuberance extending along a chord of the second substrate, the protuberance contacting the top surface of the ionically resistive element above a first region of the plurality of regions and arranged across the top surface of the ionically resistive element along one of the panels forming the first region; and
flow the electrolyte through the manifold, the electrolyte descending from the manifold into the first region via the through holes on a first side of the protuberance and ascending from the first region into the manifold via the through holes on a second side of the protuberance, forcing the air bubbles out from a portion of the ionically resistive element associated with the first region.

US Pat. No. 10,655,239

METHOD FOR PREPARING A COMPOSITE, COMPOSITE THUS OBTAINED AND USES THEREOF

UNIVERSITE DE TOURS, Tou...

1. A method for preparing a composite material comprising electrically conductive or semiconductive nano-objects of elongate shape and an electrically conductive polymer matrix,said method comprising:
(i) providing a carpet of electrically conductive or semiconductive nano-objects of elongate shape wherein the nano-objects are aligned in a vertical array; and
(ii) electrochemically depositing, via a solution containing monomer(s) precursor(s) of the electrically conductive polymer matrix, said electrically conductive polymer matrix on said carpet of electrically conductive or semiconductive nano-objects in pulsed galvanostatic mode, said pulsed galvanostatic mode comprising an electropolymerization technique with at least two successive applications of a constant current density for a period ton, separated by a rest period toff without the application of any current or voltage,
wherein the electrochemically depositing in the pulsed galvanostatic mode causes the electropolymerization of the matrix throughout an entire depth of the carpet without any modification of morphology of the carpet;
wherein in the pulsed galvanostatic mode the duration of each rest period (toff) is greater than the duration of each period of application of a constant current density (ton) by a factor of between 2 and 5.

US Pat. No. 10,655,233

ELECTROCHEMICAL AND PHOTOELECTROCHEMICAL OXIDATION OF 5-HYDROXYMETHYLFURFURAL TO 2,5-FURANDICARBOXYLIC ACID AND 2,5-DIFORMYLFURAN

Wisconsin Alumni Research...

1. A photoelectrochemical cell comprising:an anode in a single phase anode electrolyte solution comprising 5-hydroxymethylfurfural; and
a cathode in a cathode electrolyte solution;
wherein at least one of the anode and the cathode is a photoelectrode comprising a semiconductor.

US Pat. No. 10,655,230

COATED CUTTING TOOL

TUNGALOY CORPORATION, Iw...

1. A coated cutting tool comprising a substrate and a coating layer formed on a surface of the substrate, the coated cutting tool having a rake surface and a flank, in which the coating layer includes an ?-type aluminum oxide layer, wherein:the ?-type aluminum oxide layer has, on an opposite side to the substrate, a first interface, being the rake surface or a surface substantially parallel to the rake surface, a second interface, being the flank or a surface substantially parallel to the flank, and an intersecting edge between the first interface and the second interface; and
the ?-type aluminum oxide layer further satisfies conditions represented by formulae (1) and (2) below(1) A residual stress value ?r (unit: GPa) measured in the ?-type aluminum oxide layer increases continuously or stepwise as a measurement position becomes distant from the intersecting edge along the first interface with distances of 10 ?m, 50 ?m, 100 ?m, 150 ?m and 200 ?m; and(2) A residual stress value ?f (unit: GPa) measured in the ?-type aluminum oxide layer increases continuously or stepwise as a measurement position becomes distant from the intersecting edge along the second interface with distances of 10 ?m, 50 ?m, 100 ?m, 150 ?m and 200 ?m.

US Pat. No. 10,655,228

ABUTMENT FOR A TUBULAR COMPONENT OVERLAID WITH A METALLIC COMPOSITE DEPOSIT AND METHOD FOR MAKING IT

VALLOUREC OIL AND GAS FRA...

1. An abutment for a tubular component, wherein the abutment is overlaid with a coating comprising a principal layer comprising a copper-nickel alloy and wherein the coating further comprises an underlay comprising a nickel-aluminium alloy wherein the coating further comprises an additional layer comprising a nickel-tungsten alloy, said additional layer being disposed on the principal layer.

US Pat. No. 10,655,227

STABLE ELECTROLESS COPPER PLATING COMPOSITIONS AND METHODS FOR ELECTROLESS PLATING COPPER ON SUBSTRATES

Rohm and Haas Electronic ...

1. An electroless copper plating composition comprising one or more sources of copper ions, one or more carboxymethyl-thio compounds having a formula:
wherein R is a moiety selected from the group consisting of pyridinyl and dicarboxyethyl, one or more complexing agents, one or more reducing agents, and, optionally, one or more pH adjusting agents, wherein a pH of the electroless copper plating composition is greater than 7.

US Pat. No. 10,655,225

SUBSTRATE PEDESTAL MODULE INCLUDING BACKSIDE GAS DELIVERY TUBE AND METHOD OF MAKING

Lam Research Corporation,...

12. A method of processing a semiconductor substrate in a semiconductor substrate processing apparatus for processing semiconductor substrates, the method comprising:placing a substrate into a vacuum chamber on a substrate pedestal, the substrate pedestal module including a platen made of ceramic material having an upper surface configured to support the substrate thereon during processing; a stem of the substrate pedestal being made of ceramic material having an upper stein flange that supports the platen, and a backside gas tube made of ceramic material that is located in an interior of the stem, the backside gas tube including an upper gas tube flange that is located between a lower surface of the platen and an upper surface of the upper stem flange, wherein the backside gas tube is in fluid communication with at least one backside gas passage of the platen and the backside gas tube is configured to supply a backside gas to a region below a lower surface of the substrate that is to be supported on the upper surface of the platen during processing, the vacuum chamber including a processing zone in which the substrate is processed;
supplying a process gas through a showerhead module into the vacuum chamber, the process gas supplied from a process gas source that is in fluid communication with the vacuum chamber;
supplying the process gas from the process gas source into the processing zone;
supplying at least one gas selected from a backside heat transfer gas and a purge gas through the backside gas tube to a region below a lower surface of a semiconductor substrate supported on the upper surface of the platen during processing, the backside gas tube including at least one opening in the upper gas tube flange such that at least one respective electrical connection can extend through the upper gas tube flange; and
processing the substrate that is supported on the upper surface of the platen.

US Pat. No. 10,655,223

ADVANCED COATING METHOD AND MATERIALS TO PREVENT HDP-CVD CHAMBER ARCING

Applied Materials, Inc., ...

1. A process chamber, comprising:a chamber body and a lid assembly defining a volume therein, the lid assembly disposed on the chamber body;
a gas inlet positioned to introduce gas into the volume;
a substrate support positioned in the volume; and
a ring shaped gas distributor positioned in the volume beneath the substrate support, the ring shaped gas distributor comprising:
a semi-toroidal shaped body; and
a plurality of gas distribution ports disposed on a first surface of the semi-toroidal shaped body.

US Pat. No. 10,655,221

METHOD FOR DEPOSITING OXIDE FILM BY THERMAL ALD AND PEALD

ASM IP Holding B.V., Alm...

1. A method for depositing an oxide film on a substrate by thermal ALD and PEALD, comprising:providing a substrate in a reaction chamber;
depositing a first oxide film on the substrate by thermal ALD without a plasma in the reaction chamber; and
without breaking a vacuum, continuously depositing a second oxide film on the first oxide film by PEALD in the reaction chamber,
wherein a cycle of the thermal ALD comprises feeding a precursor, a reactant, and a catalytic gas to the reaction chamber, wherein the catalytic gas is neither a precursor nor a reactant and catalyzes deposition of the first oxide film by increasing reactivity of the reactant and the precursor, and the catalytic gas is fed in a pulse, without overlapping the feeding of the precursor in a pulse, in the cycle to the reaction chamber where the reactant is present.

US Pat. No. 10,655,214

METHOD OF MAKING A TANTALUM SPUTTER TARGET AND SPUTTER TARGETS MADE THEREBY

Tosoh SMD, Inc., Grove C...

1. A method of making a BCC metal or BCC metal alloy sputter target comprising the steps ofa) providing an ingot, said ingot having a generally cylindrical configuration and having an x, y and z dimensional direction,
(b) compressing said ingot in at least two of said dimensional directions,
(c) cross rolling said ingot along at least one of said dimensional directions,
(d) cutting said ingot resulting from said step (c) perpendicular to a first of said dimensional directions and parallel to a second said dimensional directions to form at least a pair of target blanks, and
(e) cross rolling each of said target blanks.

US Pat. No. 10,655,212

SPUTTER TRAP HAVING MULTIMODAL PARTICLE SIZE DISTRIBUTION

Honeywell Internatonal In...

1. A sputtering target assembly comprising:a front surface;
a back surface opposite the front surface;
a sputtering target on at least a portion of the front surface;
a backing plate mounted to the sputtering target, the backing plate including a flange extending radially from the sputtering target; and
a sputter trap formed on at least a portion of a front surface of the flange, the sputtering trap including a plurality of particles and having a particle size distribution plot with at least two distinct normal distributions.

US Pat. No. 10,655,209

ELECTROMAGNETIC SHIELD

NORITAKE CO., LIMITED, A...

1. An electromagnetic shield in which an intermediate layer is formed on a glass substrate and an electroconductive layer of Al is formed on the intermediate layer, wherein the electromagnetic shield is characterized in that:after the intermediate layer and the electroconductive layer are formed by sputtering or vacuum deposition, openings in said intermediate layer and said electroconductive layer are formed by wet etching;
the intermediate layer is a layer that is black when seen from a side of the glass substrate;
the intermediate layer consists of a mixture of molybdenum and Al2O3,
the glass substrate is a soda lime glass substrate and a layer of indium tin oxide is formed on glass surfaces at said openings formed by wet etching and on surfaces of the electroconductive layer and the intermediate layer after said openings are formed by wet etching; and
when the electromagnetic shield is left to stand for 1000 hours at a temperature of 60° C. and a relative humidity of 95%, there will be no clouding in the glass surface.

US Pat. No. 10,655,208

SLIDING MEMBER AND PISTON RING

KABUSHIKI KAISHA RIKEN, ...

1. A sliding member used in the presence of a lubricating oil, the sliding member comprising:a base member;
a metal intermediate layer formed on a sliding surface side of the base member;
a layered carbon coating formed on the metal intermediate layer and having a first carbon coating and a second carbon coating layered alternately therein; and
a hard carbon coating formed on the layered carbon coating, the hard carbon coating having a Martens hardness of 6 GPa or more and 30 GPa or less;
wherein under bright-field observation with a transmission electron microscope, an image of the first carbon coating is brighter than an image of the second carbon coating;
wherein T2 is more than 10 nm and 1000 nm or less, and T1/T2 is 0.010 or more and 0.60 or less, where T1 is a thickness of the first carbon coating, and T2 is a thickness of the second carbon coating, and
wherein the hard carbon coating is in contact with the second carbon coating.

US Pat. No. 10,655,207

ATMOSPHERIC-PRESSURE ACETYLENE CARBURIZING FURNACE

Shanghai Yibai Industrial...

1. An atmospheric-pressure acetylene carburizing furnace, comprises:a reaction chamber,
an acetylene intake duct,
an exhaust gas duct,
a control and metering apparatus arranged on the acetylene intake duct,
an exhaust gas measurement apparatus arranged on the exhaust gas duct, and
a computer controller respectively connected to the control and metering apparatus and the exhaust gas measurement apparatus,
wherein after a set temperature is reached in the reaction chamber, the computer controller is configured to turn on the control and metering apparatus according to a set parameter to introduce acetylene into the reaction chamber,
the control and metering apparatus and the exhaust gas measurement apparatus are configured to send acetylene data and exhaust gas measurement data respectively to the computer controller in real time, and
the computer controller is configured to calculate a total amount of carbon in the furnace and an enrichment rate of a workpiece, and adjust an acetylene intake volume according to the calculation result until process requirements are met.

US Pat. No. 10,655,206

SURFACE TREATMENT METHOD OF CERAMIC POWDER USING MICROWAVE PLASMA FOR ENHANCING FLOWABILITY

SEWON HARDFACING CO., LTD...

1. A surface treatment method of a ceramic powder, comprising:generating microwave plasma at atmospheric pressure using microwaves under a flow of a swirl gas and a blow gas in a tubular reactor;
introducing a ceramic powder into the tubular reactor in which the microwave plasma is generated;
allowing gas ions to be evenly adsorbed to the ceramic powder in the microwave plasma; and
collecting and distributing the ceramic powder absorbing the gas ions,
wherein, in allowing gas ions to be evenly adsorbed to the ceramic powder in the microwave plasma, the ceramic powder spirally flows along a flow direction of a swirl gas in the microwave plasma to uniformly absorb the gas ions; and
wherein flowability of the ceramic powder absorbing the gas ions is enhanced compared to the ceramic powder before absorbing the gas ions.

US Pat. No. 10,655,202

METHOD FOR MANUFACTURING ALUMINUM ALLOY MEMBER AND ALUMINUM ALLOY MEMBER MANUFACTURED BY THE SAME

MITSUBISHI HEAVY INDUSTRI...

1. A method for manufacturing an aluminum alloy member comprising:a heating step of heating an aluminum (Al) alloy containing
magnesium (Mg) at 1.6% by mass or more and 2.6% by mass or less,
zinc (Zn) at 6.0% by mass or more and 7.0% by mass or less,
copper (Cu) or silver (Ag) at 0.5% by mass or less, wherein a total amount of copper (Cu) and silver (Ag) is 0.5% by mass or less,
titanium (Ti) at 0.01% by mass or more and 0.05% by mass or less, and
aluminum (Al) and inevitable impurities as a remainder
at a temperature range of 400° C. or higher and 500° C. or lower;
an extrusion step of hot-extruding the aluminum alloy at the temperature range,
a forming step to physically form the aluminum alloy extruded in the extrusion step into a desired shape at the temperature range; and
a cooling step to cool the formed aluminum alloy at a cooling speed of 4° C./sec or more and 8° C./sec or less to obtain the aluminum alloy member,
wherein, the forming step comprises at least one of bending, crushing, punching, or trimming the extruded aluminum alloy.

US Pat. No. 10,655,195

MARTENSITIC STAINLESS STEEL

JFE STEEL CORPORATION, C...

1. A cold rolled martensitic stainless steel sheet comprising a chemical composition consisting of, in mass %:C: 0.027% or more and less than 0.10%,
Si: 0.01% or more and 2.0% or less,
Mn: 0.01% or more and 3.0% or less,
P: 0.050% or less, S: 0.050% or less,
Cr: 10.0% or more and 16.0% or less,
Ni: 0.01% or more and 0.80% or less,
Al: 0.001% or more and 0.50% or less,
N: more than 0.050% and 0.163% or less,
B: 0.0002% or more and 0.0030% or less,
Nb: 0.002% or more and less than 0.05%,
V: 0.01% or more and 0.10% or less, and
optionally one or more selected from, in mass %:
Mo: 0.01% or more and 0.50% or less,
Co: 0.01% or more and 0.50% or less,
Ti: 0.01% or more and 0.50% or less,
Zr: 0.01% or more and 0.50% or less,
Ca: 0.0002% or more and 0.0100% or less, and
Mg: 0.0002% or more and 0.0100% or less, andsatisfying the following relational expressions (1) and (2), and the balance containing Fe and incidental impurities,5×C %?N %?C %  (1)
Nb %+V %?C %+N %  (2)wherein C %, N %, Nb %, and V % indicate respectively the contents of C, N, Nb, and V (mass %) in the steel, and wherein the cold rolled martensitic stainless steel sheet has a tensile strength of 1200 MPa or more, an elongation of 7.5% or more, and an ultimate deformability of 0.5 or more, and a structure of the cold rolled martensitic stainless steel sheet is martensite single phase.

US Pat. No. 10,655,192

HOT-ROLLED STEEL SHEET

NIPPON STEEL CORPORATION,...

1. A hot-rolled steel sheet comprising: by mass %,C: 0.02% to 0.20%;
Si: more than 0% to 0.15%;
Mn: 0.5% to 2.0%;
P: more than 0% to 0.10%;
S: more than 0% to 0.05%;
Cr: 0.05% to 0.5%;
Al: 0.01% to 0.5%;
N: more than 0% to 0.01%;
Ti: 0% to 0.20%;
Nb: 0% to 0.10%;
Cu: 0% to 2.0%;
Ni: 0% to 2.0%;
Mo: 0% to 1.0%;
V: 0% to 0.3%;
Mg: 0% to 0.01%;
Ca: 0% to 0.01%;
REM: 0% to 0.1%; and
B: 0% to 0.01%,
with a remainder consisting of Fe and impurities, in which amounts of Cr and Al added satisfy Expression (1) below,
wherein a metallographic structure has, by % by volume, a ferrite fraction of more than 90% and 98% or less, a martensite fraction of 2% to less than 10%, and, furthermore, a fraction of a residual structure made of one or more of pearlite, bainite, and residual austenite being less than 1%,
the ferrite has an average circle-equivalent diameter of 4 ?m or more and a maximum circle-equivalent diameter of 30 ?m or less, and the martensite has an average circle-equivalent diameter of 6 ?m or more and 10 ?m or less and a maximum circle-equivalent diameter of 20 ?m or less,
where a tensile strength is 590 MPa or more:
[Cr]×5+[Al]?0.50  Expression (1)
here, in Expression (1), [Cr] represents an amount of Cr (mass %), and [Al] represents an amount of Al (mass %).

US Pat. No. 10,655,191

DELIVERY DEVICE USABLE IN LASER PEENING OPERATION, AND ASSOCIATED METHOD

Westinghouse Electric Com...

1. A delivery device comprising:a housing having a hollow cavity formed therein;
an inlet in fluid communication with the cavity and structured to deliver a stream of a fluid to the cavity;
an outlet in fluid communication with the cavity and structured to deliver a flow of the fluid out of the cavity, the outlet comprising a straight section and further comprising at least one of a curved entryway and a tapered region situated upstream of the straight section; and
a delivery mechanism structured to deliver a beam of electromagnetic energy out of the outlet and within the flow, the delivery mechanism comprising a lens and a laser, the lens being structured to receive the beam from the laser and to direct the beam to a focal point.

US Pat. No. 10,655,186

POINT MUTATIONS IN TRK INHIBITOR-RESISTANT CANCER AND METHODS RELATING TO THE SAME

Loxo Oncology, Inc., Sta...

1. A method of treating a subject having a Trk-associated cancer, the method comprising:(a) administering one or more doses of a first Trk inhibitor to the subject for a period of time, wherein the first Trk inhibitor is (S)—N-(5-((R)-2-(2,5-difluorophenyl)pyrrolidin-1-yl)pyrazolo[1,5-a]pyrimidin-3-yl)-3-hydroxypyrrolidine-1-carboxamide sulfate or entrectinib (N-[5-(3,5-difluoro-benzyl)-1H-indazol-3-yl]-4-(4-methylpiperazin-1-yl)-2-(tetrahydro-pyran-4-ylamino)-benzamide); and
(b) after (a), administering a treatment comprising a second Trk inhibitor to the subject, wherein the second Trk inhibitor is (6R,15R)-9-fluoro-15-methyl-2,11,16,20,21,24-hexaazapentacyclo[16.5.2.02.6.07,12.021,25]pentacosa-1(24),7,9,11,18(25),19,22-heptaen-17-one;
wherein the Trk-associated cancer is resistant to the first Trk inhibitor; and
wherein the cancer is selected from the group consisting of: adenocarcinoma, adrenal gland cortical carcinoma, adrenal gland neuroblastoma, anus squamous cell carcinoma, appendix adenocarcinoma, bladder urothelial carcinoma, bile duct adenocarcinoma, bladder carcinoma, bladder urothelial carcinoma, bone chordoma, bone marrow leukemia lymphocytic chronic, bone marrow leukemia non-lymphocytic acute myelocytic, bone marrow lymph proliferative disease, bone marrow multiple myeloma, bone sarcoma, brain astrocytoma, brain glioblastoma, brain medulloblastoma, brain meningioma, brain oligodendroglioma, breast adenoid cystic carcinoma, breast carcinoma, breast ductal carcinoma in situ, breast invasive ductal carcinoma, breast invasive lobular carcinoma, breast metaplastic carcinoma, cervix neuroendocrine carcinoma, cervix squamous cell carcinoma, colon adenocarcinoma, colon carcinoid tumor, duodenum adenocarcinoma, endometrioid tumor, esophagus adenocarcinoma, eye intraocular melanoma, eye intraocular squamous cell carcinoma, eye lacrimal duct carcinoma, fallopian tube serous carcinoma, gallbladder adenocarcinoma, gallbladder glomus tumor, gastroesophageal junction adenocarcinoma, head and neck adenoid cystic carcinoma, head and neck carcinoma, head and neck neuroblastoma, head and neck squamous cell carcinoma, kidney chromophore carcinoma, kidney medullary carcinoma, kidney renal cell carcinoma, kidney renal papillary carcinoma, kidney sarcomatoid carcinoma, kidney urothelial carcinoma, leukemia lymphocytic, liver cholangiocarcinoma, liver hepatocellular carcinoma, lung adenocarcinoma, lung adenosquamous carcinoma, lung atypical carcinoid, lung carcinosarcoma, lung large cell neuroendocrine carcinoma, lung non-small cell lung carcinoma, lung sarcoma, lung sarcomatoid carcinoma, lung small cell carcinoma, lung small cell undifferentiated carcinoma, lung squamous cell carcinoma, lymph node lymphoma diffuse large B cell, lymph node lymphoma follicular lymphoma, lymph node lymphoma mediastinal B-cell, lymph node lymphoma plasmablastic lung adenocarcinoma, lymphoma follicular lymphoma, non-Hodgkin's lymphoma, nasopharynx and paranasal sinuses undifferentiated carcinoma, ovary carcinoma, ovary carcinosarcoma, ovary clear cell carcinoma, ovary epithelial carcinoma, ovary granulosa cell tumor, ovary serous carcinoma, pancreas carcinoma, pancreas ductal adenocarcinoma, pancreas neuroendocrine carcinoma, peritoneum mesothelioma, peritoneum serous carcinoma, placenta choriocarcinoma, pleura mesothelioma, prostate acinar adenocarcinoma, prostate carcinoma, rectum adenocarcinoma, rectum squamous cell carcinoma, skin adnexal carcinoma, skin basal cell carcinoma, skin melanoma, skin Merkel cell carcinoma, skin squamous cell carcinoma, small intestine adenocarcinoma, small intestine gastrointestinal stromal tumors (GISTs), soft tissue angiosarcoma, soft tissue Ewing sarcoma, soft tissue hemangioendothelioma, soft tissue inflammatory myofibroblastic tumor, soft tissue leiomyosarcoma, soft tissue liposarcoma, soft tissue neuroblastoma, soft tissue paraganglioma, soft tissue perivascular epitheliod cell tumor, soft tissue sarcoma, soft tissue synovial sarcoma, stomach adenocarcinoma, stomach adenocarcinoma diffuse-type, stomach adenocarcinoma intestinal type, stomach adenocarcinoma intestinal type, stomach leiomyosarcoma, thymus carcinoma, thymus thymoma lymphocytic, thyroid papillary carcinoma, unknown primary adenocarcinoma, unknown primary carcinoma, unknown primary malignant neoplasm, unknown primary melanoma, unknown primary sarcomatoid carcinoma, unknown primary squamous cell carcinoma, unknown undifferentiated neuroendocrine carcinoma, unknown primary undifferentiated small cell carcinoma, uterus carcinosarcoma, uterus endometrial adenocarcinoma, uterus endometrial adenocarcinoma endometrioid, uterus endometrial adenocarcinoma papillary serous, and uterus leiomyosarcoma.

US Pat. No. 10,655,174

TAGGED MULTI-NUCLEOTIDES USEFUL FOR NUCLEIC ACID SEQUENCING

Roche Sequencing Solution...

1. A compound comprising a single tag covalently linked to a plurality of nucleoside-5?-oligophosphate moieties, wherein the tag is a molecular moiety capable of entering into, becoming positioned in, being captured by, translocating through, and/or traversing a nanopore and producing a nanopore detectable signal, and each nucleoside-5?-oligophosphate moiety is capable of being a substrate for a polymerase, wherein the compound has structural formula (IIIa), (IIIb), or (IIIc):
wherein,
Base is selected from adenosine, cytidine, guanosine, thymidine, and uridine;
R is selected from H and OH;
n is from 1 to 4;
Linker is a linker comprising a covalently bonded chain of 2 to 100 atoms; and
Tag is a molecular moiety capable of producing a detectable signal.

US Pat. No. 10,655,164

SINGLE MOLECULE DNA SEQUENCING METHOD USING CONFINED NANO-FLUIDIC CHANNEL AND SUB-NANOMETER ELECTRODE GAP

SEAGATE TECHNOLOGY LLC, ...

1. A DNA sequencing device, comprising:a passage having a width and a length;
first and second electrodes exposed within the passage and being spaced apart vertically from each other to form an electrode gap, the electrode gap having a height between the first and second electrodes, the height being no greater than about 2 nm, the height of the gap being smaller than the width of the passage, the DNA sequencing device being operable to measure with the first and second electrodes a change in electronic signal in response to nucleotides of a DNA strand passing through the electrode gap.

US Pat. No. 10,655,157

MICROBIAL ANALYSIS

KRATOS ANALYTICAL LIMITED...

1. A method of analysing microbes, the method comprising;i) a single extraction step, comprising addition of an organic extraction composition to the microbes to provide extracted material comprising both lipids and proteins,
ii) a sample preparation step, comprising preparation of at least one MALDI sample of lipid analysis incorporating the extracted material and at least one MALDI sample for protein analysis incorporating the extracted material;
iii) a data gathering step, comprising performing MALDI-based mass spectrometry on the at least one MALDI sample for lipid analysis so as to obtain mass spectrometry data on the lipid composition of the microbes and on the at least one MALDI sample for protein analysis so as to obtain mass spectrometry data on the protein composition of the microbes; and
iv) a microbe identification step, comprising analysis of the mass spectrometry data to identify microbial strain.

US Pat. No. 10,655,148

COMPOSITIONS AND METHODS FOR HELPER STRAIN-MEDIATED FUNGAL GENOME MODIFICATION

DANISCO US INC, Palo Alt...

1. A method for homologous recombination of a donor DNA with a genomic locus in a Trichoderma sp. cell; the method comprising:(a) generating a heterokaryon between a helper Trichoderma species (sp.) strain and a target Trichoderma sp, strain, wherein the helper Trichoderma sp. strain comprises an expression construct that silences the non-homologous end joining (NHEJ) mechanism, wherein the expression construct silences one or more of: ku80, ku70 and liq 4:
(b) introducing a donor DNA into the heterokaryon, wherein the donor DNA comprises a region of homology to a genomic locus in the target strain sufficient for homologous recombination at the genomic locus;
(c) generating and plating spores from the heterokaryon cells of (b); and,
(d) identifying cells from the plated spores in which (i) the donor DNA has integrated into the genome by homologous recombination at the genomic locus, and (ii) the expression construct that silences the non-homologous end joining (NHEJ) mechanism is not present.

US Pat. No. 10,655,138

THERMOSTABLE RUBISCO ACTIVASE COMPLEXES

Macquarie University, (A...

10. A method of enhancing heat tolerance in a plant comprising introducing the isolated nucleic acid of claim 1 into a plant other than Oryza australiensis and expressing the Rubisco activase, wherein expression of the Rubisco activase in the plant enhances heat tolerance of the plant at 35° C. to 45° C. as compared to a control plant lacking said isolated nucleic acid.

US Pat. No. 10,655,127

RNA AMIDATES AND THIOAMIDATES FOR RNAI

Geron Corporation, Menlo...

1. A pharmaceutical composition comprising:(a) an isolated small interfering RNA (siRNA) comprising an oligonucleotide of 19 to 25 nucleotides in length that is complementary to a target nucleic acid sequence, wherein:
all of the nucleosides of the oligonucleotide are of the formula:

wherein each R1 is independently chosen from fluorine and OR2, R2 is chosen from hydrogen and lower alkyl, and B is chosen from purines, pyrimidines, and analogs thereof; and
at least one internucleoside linkage in the oligonucleotide is a ribo-N3??P5? phosphoramidate (NP) linkage; and
wherein the small interfering RNA is selected from a single-stranded antisense form, or a double-stranded form comprising both sense and antisense strands wherein at least one strand comprises the oligonucleotide; and
(b) a pharmaceutically acceptable carrier.

US Pat. No. 10,655,121

GALVANOTAXIS ASSAY FOR QUANTITATIVE ASSESSMENT OF METASTATIC POTENTIAL OF CANCER CELLS

Ohio State Innovation Fou...

1. A system for controlling metastasis comprised of:a function generator;
a first row of a plurality of assay wells;
a second row of a plurality of assay wells;
an electromagnetic coil operably connected to the function generator and placed in between the first and second rows of assay wells and adjacent to each of the plurality of assay wells, the electromagnetic coil having a first end and a second end and wherein the electromagnetic coil induces an electric field when a waveform is applied to the electromagnetic coil by the function generator;
a plurality of well inserts each having a porous membrane, wherein each of the plurality of well inserts are adapted for placement into one of the plurality of assay wells so that each of the assay wells are divided into a lower and upper compartment; and
wherein the waveform induces an electric field across each of the porous membranes of each of the well inserts when placed in each of the plurality of assay wells.

US Pat. No. 10,655,108

CELL-DERIVED VIRAL VACCINES WITH LOW LEVELS OF RESIDUAL CELL DNA

Seqirus UK Limited, Berk...

1. A method of preparing an influenza vaccine with less than 10 ng per 0.5 ml residual DNA fragments of less than 300 base pairs, wherein the vaccine is formulated in a sub-virion form comprising immunogenic proteins derived from an influenza virus propagated on a cell culture, comprising:(i) treating the influenza virus with an alkylating agent that inactivates the influenza virus and degrades residual functional cell culture DNA, wherein the degradation is performed at a temperature that degrades the residual functional cell culture DNA into fragments of less than 300 base pairs in length, and wherein the alkylating agent is ?-propiolactone (BPL);
(ii) disrupting or fragmenting the influenza virus from step (i) with a disrupting concentration of a splitting agent, wherein the splitting agent comprises cetyltrimethylammonium bromide (CTAB); and
(iii) isolating the immunogenic proteins.

US Pat. No. 10,655,104

METHOD FOR IN VIVO, EX VIVO AND IN VITRO REPAIR AND REGENERATION OF CARTILAGE AND COLLAGEN AND BONE REMODELING

The Board of Trustees of ...

1. A hydrostatic pressure vessel comprising human chondrocytes isolated from a human having osteoarthritis, wherein the chondrocytes are present within a scaffold.

US Pat. No. 10,655,102

IDENTIFICATION AND ISOLATION OF HUMAN CORNEAL ENDOTHELIAL CELLS (HCECS)

Emmetrope Ophthalmics LLC...

11. A composition comprising: (a) human corneal cells; (b) a first positive affinity reagent that selectively binds to human corneal endothelial cells relative to human corneal endothelial cells that have undergone a fibroblastic transformation, wherein said positive affinity reagent comprises an antibody that binds to CD56 surface protein, an antibody that binds to CD166 surface protein, an antibody that binds to CAR surface protein, or an antibody that binds to CD248 surface protein, and (c) a second positive affinity reagent that selectively binds to human corneal endothelial cells relative to human corneal endothelial cells that have undergone a fibroblastic transformation and selecting cells to which the second positive affinity reagent is bound, wherein the second positive affinity reagent differs from the first positive affinity reagent.

US Pat. No. 10,655,097

T-CELL CULTURE DOUBLE BAG ASSEMBLY

Saint-Gobain Performance ...

1. A bag comprising;a gas-permeable outer bag comprising an O2- and CO2-permeable porous film and having a fluid-accessible interior volume, the outer bag having a first port and a second port attached thereto, each of the first and second port providing a fluid connection to the interior volume of the outer bag; and
a gas-permeable, framed inner bag disposed within the outer bag, the inner bag having a fluid-accessible interior volume, the inner bag comprising a sheet of an O2- and CO2-permeable porous film having a third port attached thereto that passes through the interior volume of the outer bag to the inner bag, the framed inner bag being supported by a frame,
wherein
the inner bag is smaller in size in all dimensions than the outer bag, and is connected to the outer bag only through the third port, such that the inner bag is configured to be surrounded in all directions by media disposed in the interior volume of the outer bag,
the inner bag has a pore size that allows for movement of media between the inner bag and the outer bag,
the outer bag has a pore size sufficient to contain media within the outer bag, and
the pore size of the inner bag is larger than the pore size of the outer bag.

US Pat. No. 10,655,092

EXFOLIATING MINERAL SOAP

1. A solid exfoliating mineral soap comprising:a solidified cleansing surfactant base;
a first quantity of exfoliating agent;
a second quantity of exfoliating agent; and
a water soluble muscle relaxing agent;
the first quantity of exfoliating agent being uniformly dispersed throughout the cleansing surfactant base with a first concentration;
the second quantity of exfoliating agent being concentrated on a first external surface of the cleansing surfactant base with a second concentration;
the second concentration being larger than the first concentration so as to render the first quantity of exfoliating agent and the second quantity of exfoliating agent being conjointly dispersed throughout the cleansing surfactant base in a nonuniform manner;
the water soluble muscle relaxing agent being concentrated on a second external surface of the cleansing surfactant base, the first external surface and the second external surface being located opposite to each other; and
the water soluble muscle relaxing agent comprising magnesium chloride.

US Pat. No. 10,655,091

THIOPHENE AZO DYES AND LAUNDRY CARE COMPOSITIONS CONTAINING THE SAME


US Pat. No. 10,655,087

POLISH REMOVER FORMULATIONS

1. A method for promoting the polish removing performance of a polish remover formulation, comprising including a blend comprising at least two glycerol ketal derivatives of formula I below:
wherein:
R1 and R2, independently from one another, are selected in the group consisting of: hydrogen or a linear or branched C1-C12 alkyl, a C4-C12 cycloalkyl or an aryl, and
R3 is H, a linear or branched alkyl, a cycloalkyl or a C(?O)R4 group, with R4 being a linear or branched C1-C4 alkyl or a C5-C6 cycloalkyl,
as solvent in the polish remover formulation, wherein the formulation also comprises water.

US Pat. No. 10,655,086

CATALYZED NON-STAINING HIGH ALKALINE CIP CLEANER

Ecolab USA Inc., Saint P...

1. A corrosion inhibiting and non-staining composition comprising:an alkali metal hydroxide alkalinity source, wherein the pH of a use solution of the composition is at least about 12;
from about 0.1 weight percent to about 50 weight percent of at least one chelant, wherein the at least one chelant is gluconic acid;
from about 0.001 weight percent to about 1 weight percent of a catalyst capable of decomposing an active oxygen source, wherein the catalyst is iron sulfate;a nonionic surfactant; andwater;wherein the composition is free of phosphates.

US Pat. No. 10,655,085

STEARYL AND LAURYL DIMONIUMHYDROXY ALKYL POLYGLUCOSIDES FOR ENHANCED FOOD SOIL REMOVAL

Ecolab USA Inc., Saint P...

1. A method of manufacturing a cleaning composition comprising:combining a primarily C12 quaternary functionalized alkyl polyglucoside selected from the group consisting of: stearyldimoniumhydroxypropyl laurylglucosides chloride and lauryldimoniumhydroxypropyl cocoglucosides chloride, with between about 4% and about 8% by weight of a water conditioning agent, and with water.

US Pat. No. 10,655,083

METHOD OF PROCESSING ETHANOL BYPRODUCTS AND RELATED SUBSYSTEMS

GS CLEANTECH CORPORATION,...

1. A method of recovering oil in a dry milling corn-to ethanol plant, the method comprising:dry milling corn at the ethanol manufacturing facility by converting starch in the corn to sugar;
fermenting the sugar to produce ethanol and whole stillage;
separating the whole stillage in a separator to produce a distillers wet grains and a thin stillage, wherein each of the distillers wet grains and the thin stillage contain corn oil;
evaporating the thin stillage in an evaporator in the ethanol manufacturing facility to remove water and form a concentrated byproduct, wherein the concentrated byproduct contains corn oil;.
centrifuging the concentrated byproduct in a centrifuge located downstream from the evaporator in the ethanol manufacturing facility to separate at least a portion of the corn oil from the concentrated byproduct, wherein the concentrated byproduct has a moisture content of greater than 60% and less than 85% by weight; and recovering the separated oil from the centrifuge.

US Pat. No. 10,655,080

CORN SYRUP, AN INVERSION AID FOR WATER-IN-OIL POLYMER EMULSIONS

Ecolab USA Inc., St. Pau...

1. A method of inverting a water-in-oil emulsion comprising contacting an aqueous liquid with water-in-oil emulsion comprising a polymer and from about 5 wt. % to about 25 wt. % corn syrup, whereby the water-in-oil emulsion inverts and releases the polymer and wherein the aqueous liquid comprises a high salinity brine.

US Pat. No. 10,655,079

LUBRICANT COMPOSITION

BASF SE, Ludwigshafen (D...

1. A lubricant composition comprising:a base oil present in an amount of greater than 70 parts by weight per 100 parts by weight of said lubricant composition; and
an antioxidant having the structure:

wherein each X is independently CH or N, so long wherein as at least one X is N;
wherein A is an electron donating group that:
(1) has an atom having at least one lone pair of electrons that is bonded directly to the aromatic ring; or
(2) is an aryl or alkyl group; and
wherein Z is chosen from a hydrogen atom and an electron donating group that has an atom having at least one lone pair of electrons that is bonded directly to the aromatic ring or is an aryl or alkyl group.

US Pat. No. 10,655,078

FATTY AMINE ETHOXYLATE IN POLYALKYLENE GLYCOL BASED ENGINE OILS

Dow Global Technologies L...

1. A composition comprising a polyalkylene glycol and a fatty amine ethoxylate, wherein the is at polyalkylene glycol is a butanol-initiated polyalkylene glycol and is at least 95 weight percent of the composition and the fatty amine ethoxylate having a non-cyclic structure of structure (I):where R is a linear, non-cyclic carbon-containing group with that is free of nitrogen, x and y are selected from a group consisting of zero and positive values provided that the sum of x and y are in a range of 8-20, and wherein the fatty amine ethoxylate is at least 4 weight percent relative to a combined weight of the polyalkylene glycol and a fatty amine ethoxylate.

US Pat. No. 10,655,066

OPTICAL ISOMER

DIC Corporation, Tokyo (...

1. An optical film,which comprises a structural unit derived from a compound represented by the following general formula (I-A-111), a structural unit derived from a compound represented by the following general formula (I-A-221), a structural unit derived from a compound represented by the following general formula (I-A-121), and a structural unit derived from a compound represented by the following general formula (I-A-211):

wherein P1 and P2 respectively represent a group selected from the formulae (P-1) to (P-3):
and A11, A12, and A21 each independently represent a 1,4-phenylene group or a 1,4-cyclohexylene group, wherein the group may be unsubstituted or substituted with one or more substituents L's, and L represents a fluorine atom, a chlorine atom, a bromine atom, an iodine atom, a pentafluorosulfuranyl group, a nitro group, a cyano group, an isocyano group, an amino group, a hydroxyl group, a mercapto group, a methylamino group, a dimethylamino group, a diethylamino group, a diisopropylamino group, a trimethylsilyl group, a dimethylsilyl group, a thioisocyano group, or a linear or branched alkyl group having 1 to 20 carbon atoms in which one —CH2— group or two or more —CH2— groups that are not adjacent to each other each may be independently substituted by —O—, —S—, —CO—, —COO—, —OCO—, —CO—S—, —S—CO—, —O—CO—O—, —CO—NH—, —NH—CO—, —CH?CH—COO—, —CH?CH—OCO—, —COO—CH?CH—, —OCO—CH?CH—, —CH?CH—, —CF?CF—, or —C?C—, and one or more of arbitrary hydrogen atoms in the alkyl group may be substituted by a fluorine atom, or L represents a group represented by the following formula (I-RL):wherein, PL represents a group selected from the above formulae (P-1) to (P-3), RSL represents a linear or branched alkyl group having 1 to 20 carbon atoms in which one —CH2— group or two or more —CH2— groups that are not adjacent to each other each may be independently substituted by —O—, —S—, —CO—, —COO—, —OCO—, —CO—S—, —S—CO—, —O—CO—O—, —CO—NH—, —NH—CO—, —CH?CH—COO—, —CH?CH—OCO—, —COO—CH?CH—, —OCO—CH?CH—, —CH?CH—, —CF?CF—, or —C?C—, and one or more of arbitrary hydrogen atoms in the alkyl group may be substituted by a fluorine atom or a chlorine atom, SpL represents an alkylene group having 1 to 20 carbon atoms, wherein plural SpL groups, if present, may be the same or different, XL represents —O—, —S—, —OCH2—, —CH2O—, —CO—, —COO—, —OCO—, —CO—S—, —S—CO—, —O—CO—O—, —CO—NH—, —NH—CO—, —SCH2—, —CH2S—, —CF2O—, —OCF2—, —CF2S—, —SCF2—, —CH?CH—COO—, —CH?CH—OCO—, —COO—CH?CH—, —OCO—CH?CH—, —COO—CH2CH2—, —OCO—CH2CH2—, —CH2CH2—COO—, —CH2CH2—OCO—, —COO—CH2—, —OCO—CH2—, —CH2—COO—, —CH2—OCO—, —CH?CH—, —CH?N—N?CH—, —CF?CF—, —C?C—, or a single bond, wherein plural XL groups, if present, may be the same or different, kL represents an integer of 0 to 10, and nL1 and nL2 each independently represent an integer of 0 to 8), wherein plural L groups, if present in the compound, may be the same or different, and Z11 and Z12 each independently represent —OCH2—, —CH2O—, —CH2CH2—, —COO—, —OCO—, —CO—NH—, —NH—CO—, —CH?CH—COO—, —CH?CH—OCO—, —COO—CH?CH—, —OCO—CH?CH—, —COO—CH2CH2—, —OCO—CH2CH2—, —CH2CH2—COO—, —CH2CH2—OCO—, or a single bond;
wherein P1 and P2 respectively represent the same meanings as in P1 and P2 in the general formula (I-A-111), and A11, A12, A21, Z11, and Z12 respectively represent the same meanings as in A11, A12, Z11, and Z12 in the general formula (I-A-111);

wherein P1 and P2 respectively represent the same meanings as in P1 and P2 the general formula (I-A-111), and A11, A12 and Z12 respectively represent the same meanings as in A11, A12, A21, Z11, and Z12 in the general formula (I-A-111); and

wherein P1 and P2 respectively represent the same meanings as in P1 and P2 in the general formula (I-A-111), and A11, A12, A21, Z11, and Z12 respectively represent the same meanings as in A11, A12, A21, Z11, and Z12 in the general formula (I-A-111).

US Pat. No. 10,655,062

HIGHLY VERTICAL DIELECTRIC LIQUID CRYSTAL COMPOSITION AND LIQUID CRYSTAL DISPLAY DEVICE

SHIJIAZHUANG CHENGZHI YON...

1. A liquid crystal composition comprising one or more of compounds represented by formulas I1 to I14; one or more of compounds represented by formulas II1 to II14; and one or more of compounds represented by formulas III1 to III5:
wherein:
R11 and R31 each independently represents an alkyl group having a carbon atom number of 1-6;
R21 each independently represents an alkyl group having a carbon atom number of 1-5; and
R51 and R61 each independently represents an alkyl group having a carbon atom number of 1-6, an alkoxy group having a carbon atom number of 1-6, an alkenyl group having a carbon atom number of 2-6 or an alkenoxy group having a carbon atom number of 3-6.

US Pat. No. 10,655,059

COMPOUND AND CONTRAST AGENT FOR OPTICAL IMAGING HAVING THE COMPOUND

Canon Kabushiki Kaisha, ...

1. A compound represented by any one of Formulae (I) to (III) and having a molecular weight of 1600 or more and 40000 or less;
wherein in Formulae (I) to (III) above, n and m each independently represent an integer of 12 or more, R101 to R112 each independently represent any one of a hydrogen atom, a halogen atom, an acetoxy group, an alkyl group having 1 to 18 carbon atoms, an alkyl ester group having 1 to 18 carbon atoms, and an alkylamide group having 1 to 18 carbon atoms,
R11 to R14 each independently represent an alkyl group having 1 to 18 carbon atoms or a fluorinated alkyl group having 1 to 18 carbon atoms,
L11 to L17 each independently represent substituted or unsubstituted methine and a substituent of methine is an alkyl group having 1-4 carbon atoms or a halogen atom, L11 and L13, L12 and L14, L13 and L15, and L14 and L16 may form a five-membered ring or a six-membered ring, A11 and A12 represent alkylene groups having 1 to 3 carbon atoms, A13 and A14 represent alkylene groups having 2 to 5 carbon atoms, Q11 and Q12 represent —CONH—, and B11 and B12 represent;

US Pat. No. 10,655,058

TREATMENT FLUIDS FOR STIMULATION OF SUBTERRANEAN FORMATIONS

Halliburton Energy Servic...

1. A method comprising:introducing a treatment fluid into a subterranean formation, the treatment fluid comprising a pseudo-crosslinking agent and an acidic viscoelastic surfactant (AVS) base fluid,
acidizing the subterranean formation with the treatment fluid to dissolve acid-soluble materials, wherein the acidizing is completed in a single stage; and
diverting the treatment fluid to untreated zones of the subterranean formation,
wherein the treatment fluid has a pH of less than 5,
wherein the AVS base fluid includes a zwitterionic viscoelastic surfactant, an acidic constituent, and a polar solvent, and
wherein the zwitterionic viscoelastic surfactant is present in an amount in a range of from about 0.001% to about 15% by weight of active surfactant of the AVS base fluid.

US Pat. No. 10,655,057

METHODS AND MATERIALS FOR TREATING SUBTERRANEAN FORMATIONS USING A THREE-PHASE EMULSION BASED FRACTURING FLUID

Saudi Arabian Oil Company...

1. An emulsion for hydraulic fracturing of a formation, the emulsion comprising:a first aqueous phase comprising a breaker and an ester;
a second aqueous phase comprising a fracturing fluid and a proppant; and
a hydrocarbon phase separating the first aqueous phase and second aqueous phase, wherein the emulsion is a solid-stabilized emulsion stabilized by a plurality of polylactate particles, wherein the emulsion has a viscosity of at least 19 centipoise (cP) and is intact for at least 6 hours at a temperature of 200° F.

US Pat. No. 10,655,056

GUANIDINE- OR GUANIDINIUM-CONTAINING COMPOUNDS FOR TREATMENT OF SUBTERRANEAN FORMATIONS

Halliburton Energy Servic...

1. A system comprising:a tubular disposed in a subterranean formation;
a composition comprising a clay or shale stabilizer comprising at least one of the following structures:
wherein the variable R8 is a (C2-C5) alkyl group; anda pump configured to pump the composition in the subterranean formation through the tubular.

US Pat. No. 10,655,055

WEAK GEL SYSTEM FOR CHEMICAL ENHANCED OIL RECOVERY

Ecolab USA Inc., St. Pau...

1. A method of increasing the sweep efficiency of a fluid flood of a subterranean hydrocarbon-bearing formation to enhance hydrocarbon recovery from the formation, the method comprising:introducing either a water soluble acrylamide polymer and a non-metallic organic crosslinking agent, or a crosslinkable acrylamide polymer, into an injection fluid entering a wellbore or the formation to form a crosslinked polymer in a high permeability zone existing within the formation;
discontinuing hydrocarbon production from the formation being treated for a time period sufficient to allow the viscosity of the crosslinked polymer within the high permeability zone to increase so that the crosslinked polymer remains fixed within the high permeability zone to divert fluid flow into unswept zones of the formation;
after the discontinuation step, introducing injection fluid into the formation being treated to flood the formation, mobilize the hydrocarbon and form a flood fluid containing a mobilized hydrocarbon; and
removing the flood fluid containing the mobilized hydrocarbon from the well as a produced fluid,
wherein the non-metallic organic crosslinking agent comprises a polymeric polyamine which is either (i) a reaction product of a polymerization mixture comprised of at least one monomer of Formula II or a salt thereof; or (ii) comprised of at least one structural unit of Formula IIA, wherein Formulae II and IIA have the following structures:

wherein:
R1 is hydrogen, a protecting group, or alkyl; and
R2, R3, R4, R5, R6 and R7 are each independently hydrogen, alkyl, or alkoxylalkyl; and
the crosslinkable acrylamide polymer comprising a reaction product of a polymerization mixture comprised of at least one acrylamide monomer and at least one monomer of the Formula II or a salt thereof.

US Pat. No. 10,655,053

METHODS AND COMPOSITIONS FOR DIVERSION DURING ENHANCED OIL RECOVERY

Saudi Arabian Oil Company...

1. A method for isolating a first region and a proximate second region of a subterranean formation, the method comprising:introducing an asphaltene composition into the first region of the subterranean formation, the asphaltene composition comprising asphaltene dissolved in a solvent, the solvent comprising an alkyl alcohol, an alkyl aromatic, and 40 to 85 wt. % chloroform based on a total weight of the solvent, in which:
the asphaltene composition has a weight ratio of solvent to asphaltene from 5:1 to 20:1, and
the solvent comprises from 5 to 50 wt. % alkyl aromatic based on a total weight of the solvent; and
after introducing the asphaltene composition, introducing an aqueous composition to the first region in order to precipitate the asphaltene in the first region, where the precipitated asphaltene forms a barrier that isolates the second region from at least a portion of the first region.

US Pat. No. 10,655,048

OIL WELL CEMENT SETTLEMENT STABILIZER FOR HIGH-TEMPERATURE CEMENTING OF OIL AND GAS WELLS AND PREPARATION METHOD THEREOF, AND CEMENT SLURRY

China University of Petro...

1. A well cementing cement slurry comprising an oil well cement settlement stabilizer, the oil well cement settlement stabilizer comprising a quaternary cement settlement stabilizer;wherein the quaternary cement settlement stabilizer contains structural units A represented by formula (I), structural units B represented by formula (II), structural units C represented by formula (III), and structural units D represented by formula (IV); wherein the molar ratio of the structural units A to the structural units B to the structural units C to the structural units D is x:y:z:q=1:(0.09-0.34):(0.28-0.36):(0.03-0.05);

wherein R1, R2, R3 and R8 are the same as or different from each other, and are H or C1-C4 substituted or unsubstituted alkyl respectively and independently;
wherein m is 15, 17, 19 or 21;
wherein based on the total weight of the well cementing cement slurry, a dose of the quaternary cement settlement stabilizer of an oil well is 0.4-0.8 wt %.

US Pat. No. 10,655,047

PLUGGING AND ABANDONING A WELL USING EXTENDED-LIFE CEMENT COMPOSITIONS

Halliburton Energy Servic...

1. A method of cementing comprising:providing an extended-life cement composition comprising calcium aluminate cement, water, and a cement set retarder, wherein the cement set retarder is present in an amount of about 0.01% to about 10% by weight of the extended-life cement composition;
storing the extended-life cement composition in a vessel for a time period of at least about 7 days or longer,
mixing the extended-life cement composition with a cement set activator to activate the extended-life cement composition;
introducing the activated extended-life cement composition into a wellbore; and
allowing the activated extended-life cement composition to set in the wellbore to form a plug in the wellbore that has a permeability of less than 0.1 millidarcy, the composition having a 7-day compressive strength of 4,000 psi or greater.

US Pat. No. 10,655,046

CEMENT HAVING CROSS-LINKED POLYMERS

SAUDI ARABIAN OIL COMPANY...

1. A cement composition for use in a wellbore comprising:a cement;
a calcium silicate in the cement; and
a polyaramide condensate compound that is cross-linked and formed from a trifunctional carboxylic acid and a diamine, where the polyaramide condensate compound comprises poly-(meta-phenylene trimesoylamide).

US Pat. No. 10,655,043

COMPOSITIONS AND METHODS FOR SERVICING SUBTERRANEAN WELLS

Schlumberger Technology C...

7. A method for cleaning a wellbore in a subterranean well that has been drilled with a water-base drilling fluid, comprising:(i) providing an aqueous treatment fluid comprising water and hydrophobic fibers;
(ii) circulating the treatment fluid in the wellbore; and
(iii) removing the treatment fluid from an interior of a casing and formation surfaces of the wellbore without use of a plug.

US Pat. No. 10,655,038

METHOD OF MAKING MAGNETIZABLE ABRASIVE PARTICLES

3M Innovative Properties ...

1. A method of making magnetizable abrasive particles, the method comprising sequentially:providing a slurry layer disposed on a releasable substrate, wherein the slurry layer has an exposed surface, and wherein the slurry layer comprises magnetic particles, a binder precursor, and a liquid vehicle;
electrostatically contacting abrasive particles with the slurry layer, wherein the abrasive particles are aligned substantially oriented perpendicular to the surface of the releasable substrate, and wherein the abrasive particles are partially embedded within the slurry layer;
at least partially removing the liquid vehicle from the slurry layer and converting the binder precursor into a binder to provide a magnetizable layer comprising the magnetic particles and the binder, wherein the abrasive particles are partially embedded in the magnetizable layer;
separating the magnetizable abrasive particles from the releasable substrate, wherein the magnetizable abrasive particles each respectively comprise a portion of the magnetizable layer is disposed on a portion of each of the abrasive particles.

US Pat. No. 10,655,036

ADHESIVE SHEET AND ADHESIVE SHEET PRODUCTION METHOD

LINTEC CORPORATION, Itab...

1. A pressure sensitive adhesive sheet, comprising:a substrate or a release material; and
a resin layer provided on the substrate or the release material and comprising a resin part (X) comprising a resin as a main component and a particle part (Y) consisting of fine particles having a mean particle size of 0.01 to 100 ?m,
wherein the fine particles comprise at least one selected from the group consisting of silica particles comprising 85 to 100% by mass of silica, metal oxide particles, and smectite particles,
at least a surface (?) of the resin layer on the side opposite to the side on which the substrate or the release material is provided has pressure sensitive adhesiveness,
a concave portion and a plurality of flat faces having an irregular shape exist in a region (Dc) surrounded by a circle having a diameter of 8 mm that is arbitrarily selected on the surface (?) of the resin layer,
the plurality of flat faces comprises a flat face (f1) having an area within which a region surrounded by a circle having a diameter of at least 100 ?m is selectable, and
with respect to at least one flat face (S) in the plurality of flat faces excluding flat faces having a cumulative relative frequency of 30% or less determined by adding relative frequency from the respective flat faces with a smaller area, when the region (Dc) containing one or more of the flat faces (S) is placed on an orthogonal coordinate system such that a direction orthogonal to the horizontal Feret's diameter direction is the vertical Feret's diameter direction, an rMAX value of the one or more of the flat faces (S) calculated from the following Operations (i) to (iii) is 0.60 or less:
Operation (i): with respect to all of the one or more of the flat faces (S) contained in the region (Dc), a ratio of an area of the flat face (S) to an area of a circumscribed rectangle of flat face (S) which circumscribes the flat face (S) by two pairs of straight lines parallel to the horizontal Feret's axis and the vertical Feret's axis [{area of flat face (S)}/{area of circumscribed rectangle of flat face (S)}] is calculated for every flat face (S), and r(0°) that is an average value of the obtained ratios is calculated;
Operation (ii): with respect to each of all of the one or more of the flat faces (S) in each region obtained by rotating the region (Dc) at ?, where ?=15°, 30°, 45°, 60°, 75°, or 90°, in the counterclockwise direction centering on, as a center of the rotation, the center of the circle of the region (Dc) used in the Operation (i) in the orthogonal coordinate system, a ratio of an area of the flat face (S) to an area of a circumscribed rectangle of flat face (S), which circumscribes the flat face (S) by two pairs of straight lines parallel to the horizontal Feret's axis and the vertical Feret's axis [{area of flat face (S)}/{area of circumscribed rectangle of flat face (S)}] is calculated for every flat face (S), and r(?) that is an average value of the obtained ratios is calculated with respect to every case at ?=15°, 30°, 45°, 60°, 75°, and 90°; and
Operation (iii): a maximum value of the seven values of r(?), where ?=0°, 15°, 30°, 45°, 60°, 75°, and 90°, as calculated in the Operations (i) and (ii) is defined as the rMAX value of the one or more of the flat faces (S).

US Pat. No. 10,655,035

OXIDIZING FLUID FOR THE CHEMICAL-MECHANICAL POLISHING OF CERAMIC MATERIALS

1. A fluid composition for chemical-mechanical polishing, comprising:a solvent;
0.5-5 wt % of a first oxidizing agent comprising an ion, salt, acid, or base of permanganate or Ce+4 and having an oxidation potential of 0.4 V or greater;
0.1-0.5 wt % of a second oxidizing agent comprising an ion, salt, acid, or base of persulfate and having a higher oxidation potential than the first oxidizing agent and 0.05-0.75 wt % of a multivalent cation component comprising Al+3, Fe+3, or Co+3.

US Pat. No. 10,655,030

WATER-BASED INK

KAO CORPORATION, Tokyo (...

1. An ink set for ink-jet printing comprising two or more kinds of water-based inks which are each constituted of a water-based ink comprising a pigment (A), a water-insoluble polymer (B), an organic solvent (C), a surfactant (D) and water, wherein pigment (A) in each kind of water-based ink differs in color from pigment (A) in every other kind of water-based ink in said ink set, in which:the pigment (A) is present in the water-based ink in the form of pigment-containing water-insoluble polymer particles;
the organic solvent (C) comprises at least a glycol ether (c-1) which has a viscosity of not less than 2.0 mPa·s and not more than 7.0 mPa·s as measured at 20° C. and a vapor pressure of not less than 0.01 hPa and not more than 7.0 hPa as measured at 20° C., and a content of a glycol ether having a viscosity of not less than 6.0 mPa·s as measured at 20° C. as a component of the glycol ether (c-1) in the water-based ink is not less than 0% by mass and not more than 5% by mass, a content of the organic solvent (C) in the water-based ink is not less than 25% by mass and not more than 45% by mass, a content of water in said water-based inks is 40% to 85% by mass, and a content of a high-boiling organic solvent having a boiling point of not lower than 250° C. in the water-based ink is not more than 5% by mass; and
the surfactant (D) comprises a silicone-based surfactant (d-1), and a content of the silicone-based surfactant (d-1) in the water-based ink is not less than 0.005% by mass and not more than 0.3% by mass, wherein a kinematic viscosity of the silicone-based surfactant (d-1) as measured at 25° C. is not less than 40 mm2/s and not more than 1000 mm2/s, and wherein a HLB value of the silicone-based surfactant (d-1) is not less than 2.0,
wherein the glycol ether (c-1) is at least one compound selected from the group consisting of ethylene glycol isopropyl ether, ethylene glycol propyl ether, diethylene glycol isopropyl ether and diethylene glycol isobutyl ether,
wherein the set consists of three of the water based inks, one of which contains yellow pigment, one of which contains magenta pigment, and one of which contains cyan pigment,
wherein water has a largest content among components of a medium contained in said water-based inks;
wherein the organic solvent (C) further comprises an organic solvent (c-2) other than the glycol ether (c-1), and the organic solvent (c-2) further comprises an alkanediol having not less than 2 and not more than 6 carbon atoms, and
wherein a content of the glycol ether (c-1) in the organic solvent (C) is not less than 30% by mass and not more than 90% by mass;
wherein the silicone-based surfactant (d-1) is a polyether-modified silicone-based surfactant represented by the following general formula (1):

wherein R1 is an alkyl group having 1 to 3 carbon atoms or a hydroxy group; R2 is an alkanediyl group having 2 to 5 carbon atoms: R3 is a hydrogen atom, an alkyl group having 1 to 3 carbon atoms or a hydroxy group; PO is a propyleneoxy group; EO is an ethyleneoxy group; a, b, m and n represent average molar numbers of addition of the respective constitutional units, and a is a number of 0 to 10, b is a number of 1 to 50, m is a number of 1 to 500 and n is a number of 1 to 50; and a plurality of the R1 groups may be the same or different from each other; and in the general formula (1), a, b, m and n have the following ranges:
[a+b] is not less than 5 and not more than 35,
[m/n] is not less than 3 and not more than 20, and
[a+b]/[m+n] is not less than 0.5 and not more than 6.

US Pat. No. 10,655,025

CURABLE UNSATURATED CRYSTALLINE POLYESTER POWDER AND METHODS OF MAKING THE SAME

XEROX CORPORATION, Norwa...

1. A process for making a composition comprising:providing an unsaturated polyester resin comprising:
an ethylenically unsaturated monomer having the formula I

wherein p and q are each independently 0 to 8, and z is 1 to 5,
a first diol monomer; and
a second diol monomer;
mixing and heating a mixture comprising the unsaturated polyester resin and an oil at a temperature above the melting point temperature (Tm) of the unsaturated polyester resin, and applying a pressure to the mixture to form a microparticle composite;
washing the microparticle composite with an organic solvent to reduce the amount of oil present in the microparticle composite;
adding a thermal initiator to the microparticle composite; and
removing the organic solvent to form the composition comprising microparticles with the thermal initiator on the surface of the microparticles.

US Pat. No. 10,655,024

FLEXIBLE, BIODEGRADABLE, AND BIOCOMPATIBLE SUPERCAPACITORS

Virginia Commonwealth Uni...

1. A supercapacitor, comprisinga flexible protein substrate,
at least two electrodes comprising a biocompatible conductive ink patterned on the flexible protein substrate, and
a biocompatible gel electrolyte connecting the at least two electrodes,
wherein each of the flexible protein substrate, the at least two electrodes, and the gel electrolyte are biodegradable.

US Pat. No. 10,655,020

CELLULAR GRAPHENE FILMS

The Regents of the Univer...

1. A reduced graphene oxide film comprising a continuous three-dimensional network of pores having a size of less than 1,000 nm, wherein the film has a density of at least about 0.1 g/cm3.

US Pat. No. 10,655,017

PYRIMIDOQUINAZOLINE PIGMENT, METHOD FOR MANUFACTURING PYRIMIDOQUINAZOLINE PIGMENT, AND PIGMENT COLORANT

1. A pyrimidoquinazoline pigment represented by following formula (1):wherein R1 and R2 in the formula (1) each independently represent a benzene ring or a naphthalene ring optionally having a substituent,wherein the optional substituent for each of the R1 and R2 in the formula (1) is at least one group each independently selected from the group consisting of methyl, t-butyl, phenyl, chloro, bromo, methoxy, phenoxy, and thiophenoxy.

US Pat. No. 10,655,013

BLOW-MOLDABLE POLYAMIDE COMPOSITIONS

BASF SE, Ludwigshafen (D...

1. A thermoplastic molding composition comprisingA) from 10 to 94% by weight of a polyamide,
B) from 10 to 25% by weight of an impact modifier selected from the group consisting of
a copolymer I of
B1) from 35 to 89.9% by weight of ethylene
B2) from 10 to 60% by weight of 1-octene or 1-butene or propylene or a mixture of these and
B3) from 0.05 to 5% by weight of functional monomers, where the functional monomers are selected from the group consisting of the carboxylic acid groups, carboxylic anhydride groups, carboxylic ester groups, carboxamide groups, carboximide groups, amino groups, hydroxy groups, epoxy groups, urethane groups, oxazoline groups, and mixtures thereof,
a copolymer II of
B1) from 50 to 98% by weight of ethylene
B4) from 2 to 50% by weight of acrylic acid or methacrylic acid, and
B5) optionally from 0 to 20% by weight of functional monomers selected from the group consisting of carboxylic anhydride groups, epoxy groups, and mixtures thereof,
or a mixture of copolymer I and copolymer II,
C) from 0.1 to 10% by weight of a copolymer of
C1) from 50 to 95% by weight of styrene or substituted styrenes of the general formula I or a mixture of these

in which R is an alkyl radical having from 1 to 8 carbon atoms or a hydrogen atom and R1 is an alkyl radical having from 1 to 8 carbon atoms and n has the value 0, 1, 2, or 3, and
C2) from 5 to 50% by weight of structural units derived from one or more dicarboxylic anhydrides,
D) from 0.001 to 20% by weight of iron powder wherein the C content of component D) is from 0.01 to 1.2 g/100 g when measured by a method based on ASTM E1019,
E) from 0.05 to 3% by weight of a copper-containing stabilizer,
F) from 100 ppm to 5% by weight of alkali metal salts or alkaline earth metal salts of oxo acids of phosphorus or a mixture of these,
G) from 0 to 2% by weight of a polyethyleneimine homo- or copolymer,
H) from 0 to 60% by weight of further additives selected from the group consisting of a fibrous filler, a particulate filler, a lubricant, a nigrosin, oxidation retarders, UV stabilizers, dyes, pigments, nucleating agents, heat stabilizers, flame retardants, mold release agents, and plasticizers,
wherein:
the total of the percentages by weight of A) to H) is 100%,
the molding composition exhibits a surface roughness of class 3 or class 4,
the molding composition is free of free of copolymers comprising ethylene and (meth)acrylate co-monomers, and
the molding composition is free of a sterically hindered phenol.

US Pat. No. 10,655,012

PROCESS FOR THE PREPARATION OF POLYURETHANE SOLUTIONS BASED ON SILICON-POLYCARBONATE DIOLS

Aortech International plc...

1. A process for preparing a polyurethane solution comprising:(a) reacting a polycarbonate siloxane diol of formula I(a)
wherein R1, R2, R3, and R4 are methyl, R8 is ethyl, R9 is hexyl, R5 and R6 are propyl or butyl, R7 is O, n is 1, x is an integer of about 1-50, and z and y are integers of 0 or more, prepared by reaction of a carbonate source, with a bis(hydroxyC3-C4alkyl)(tetramethyldisiloxane), in the presence of an initiator catalyst; with a diisocyanate, to form a prepolymer;(b) stirring and heating the prepolymer to about 75-80° C.;
(c) chain extending the prepolymer by reaction with an alkylene diol, to yield a polyurethane;
(d) adding dimethylacetamide to the stirred, heated polyurethane to yield about a 15-50 wt-% solution, of said polyurethane; and
(e) cooling the solution to about 20-30° C., so as to yield a polyurethane solution having a viscosity in the range of about 1000-2000 mPas at about 17% solids.

US Pat. No. 10,655,007

POLYALKYLENE TEREPHTHALATE RESIN COMPOSITION

POLYPLASTICS CO., LTD., ...

1. An insert molded article obtained by performing insert molding using a polyalkylene terephthalate resin composition and an insert member comprising a metal or an inorganic solid, whereinthe polyalkylene terephthalate resin composition comprises (A) a polyalkylene terephthalate resin, and (B) an acrylic-based core-shell polymer which has an average particle size of 2 ?m or greater and in which an amount of a core layer component is at least 85% by mass but not more than 95% by mass relative to a total mass of the core layer component and a shell layer component, an amount of (B) the acrylic-based core-shell polymer is at least 10 parts by mass but not more than 30 parts by mass per 100 parts by mass of (A) the polyalkylene terephthalate resin,
the polyalkylene terephthalate resin composition further comprises (C) a filler in an amount of at least 10 parts by mass but not more than 100 parts by mass per 100 parts by mass of (A) the polyalkylene terephthalate resin,
(A) the polyalkylene terephthalate resin comprises a polybutylene terephthalate resin, the core layer component of (B) the acrylic-based core-shell polymer comprises a polymer formed using a C1 to C12 alkyl acrylate, the shell layer component of (B) the acrylic-based core-shell polymer comprises a polymer formed using a C1 to C20 alkyl methacrylate, and
the polyalkylene terephthalate resin composition is a composition wherein, when the following insert molded article A is produced, the insert molded article A satisfies the following heat shock resistance condition A, wherein
insert molded article A: an insert molded article into which an L-shaped iron plate with 21 mm in a width×90 mm×90 mm and a thickness of 1.6 mm is inserted, and in which a resin portion is an L-shaped plate with 25 mm in a width×70 mm×70 mm and a thickness of 3.6 mm, in which a minimum wall thickness in part of the resin portion is 1 mm, and
heat shock resistance condition A: in a heat shock resistance test using a thermal shock tester in which a process of performing heating at 140° C. for 1 hour and 30 minutes, subsequently lowering a temperature to ?40° C. and performing cooling for 1 hour and 30 minutes, and then raising a temperature back to 140° C. is deemed one cycle, a number of cycles performed before cracking appears in the molded article is at least 100, and
the insert member is a plate-like electrical connection conductor, and the insert member has a ratio of 12.5 or greater for a maximum width relative to a maximum thickness in a cross-section perpendicular to a lengthwise direction of a planar surface of the plate-like conductor.

US Pat. No. 10,655,006

BINDER-TREATED FIBROUS MATERIALS

CYTEC TECHNOLOGY CORP., ...

1. A fibrous material comprising a binder composition distributed therein or coated thereon,wherein said fibrous material is selected from: a woven or nonwoven fabric; a nonwoven layer of randomly arranged fibers, fiber tows, yarns, braids, textile tape suitable for automated fibre placement (AFP) and/or automated tape laying (ATL),
wherein said binder composition comprises:
(a) one or more multifunctional epoxy resins;
(b) at least one thermoplastic polymer that is soluble in one or more epoxy resins upon curing of the epoxy resin(s); and
(c) a nonionic surfactant which is a block copolymer comprising hydrophilic and hydrophobic blocks,
wherein the binder composition is present in an amount within the range of 1% to 20% by weight based on the total weight of the fibrous material, and the fibrous material is permeable to liquid resin, and
wherein the fibrous material is a dry, flexible material that is tack-free at room temperature (20° C.-25° C.).

US Pat. No. 10,655,004

ELECTROCHEMICAL SENSOR SYSTEM

Ascensia Diabetes Care Ho...

1. A method of determining an analyte concentration, the method comprising the acts of:placing a hydrogel composition on skin, the hydrogel composition comprising a first monomer, a second monomer, a cross-linking agent, and a solvent, the first monomer being selected from Formula I
wherein the combination of R and R1 is selected from 1 carbon to 5 carbon atoms such that a 3-7 member heterocyclic moiety is formed;the second monomer being selected from Formula IV, wherein Formula IV is
whereinR2 is selected from (C3-C7)cycloalkyl, wherein the cycloalkyl is optionally substituted with one or more substituents selected from alkyls, halos, haloalkyls, cycloalkyls, nitros, and cyanos;wherein the ratio of the first monomer to the second monomer is from about 20:80 to about 80:20;
providing a sensor, the hydrogel composition located generally between and coupling the skin and the sensor; and
sampling of the interstitial fluid to determine the analyte concentration using the sensor.

US Pat. No. 10,655,002

RESIN BLEND FOR MELTING PROCESS

LG CHEM, LTD., Seoul (KR...

1. A resin article comprising:a first resin; and
a second resin that is a (meth)acrylate-based resin to which at least one organic functional group selected from the group consisting of tertiary butyl group, isobutyl group, isobornyl group, cyclohexyl group, and phenyl group is introduced, that has a difference in melt viscosity from the first resin of 0.1 to 3000 pa*s at a shear rate of 100 to 1000 s?1 at a processing temperature of the resin blend, and that has a difference in glass transition temperature from the first resin of 10° C. to 100° C.,
wherein the first resin includes an acrylate-based resin,
wherein the resin article has a layer-separated structure in which the first resin is disposed inside of the layer-separated structure and the second resin is disposed on a surface of the layer-separated structure during melt processing under shear stress, and has an impact resistance of 6.7 to 8.8 kg*cm/cm in an IZOD ?? test and of 6.5 to 9.1 kg*cm/cm in an IZOD ¼? test measured according to ASTM D256, and a pencil hardness of 2H to 3H measured according to ASTM 3363-74.

US Pat. No. 10,654,991

GRANULAR MATERIAL, GRANULAR MATERIAL MANUFACTURING METHOD, THREE-DIMENSIONAL LAMINATED AND SHAPED MOLD MANUFACTURING APPARATUS, AND THREE-DIMENSIONAL LAMINATED AND SHAPED MOLD MANUFACTURING METHOD

TECHNOLOGY RESEARCH ASSOC...

1. A granular material for use in three-dimensional laminated mold shaping, comprising:(a) a mixed or coated material comprising a refractory granular raw material mixed with or coated with a first acid that, when printed with an organic binder, serves as a catalyst to activate and harden the organic binder to bind the granular material; and
(b) a hardening accelerator,
wherein the hardening accelerator is a second material that, when the mixed or coated material is printed with the organic binder, (i) undergoes a metathesis reaction to generate a second acid that catalyzes a hardening reaction of the organic binder; (ii) causes a hydration reaction with water generated during the hardening reaction to increase a rate of the hardening reaction, and (iii) absorbs moisture;
wherein the first acid contains at least one of sulfuric acid, phosphoric acid, and a sulfonic acid, and wherein the sulfonic acid contains at least one of p-toluenesulfonic acid, xylene sulfonic acid, benzene sulfonic acid, and methane sulfonic acid.

US Pat. No. 10,654,990

THERMAL STABILIZER COMPOSITION AND SYNTHETIC RESIN COMPOSITION COMPRISING SAME

ADEKA CORPORATION, Tokyo...

1. A thermal stabilizer composition, consisting of comprising:100 parts by mass of a phosphorus-based antioxidant having a phosphite structure;
0.01 to 5 parts by mass of a phenolic antioxidant; and
optionally, one or more resin additives,
wherein said phenolic antioxidant has a substructure represented by the following Formula (2?):

wherein, n represents an integer of 1 to 4;
when n is 1, X represents an alkyl group having 1 to 40 carbon atoms, an alkoxy group having 1 to 40 carbon atoms, an aryl group having 6 to 40 carbon atoms, an arylalkyl group having 7 to 40 carbon atoms or a combination thereof;
when n is 2, X represents an alkylidene group having 1 to 40 carbon atoms, an arylene group having 6 to 40 carbon atoms or a group represented by the following Formula (3):

wherein, R6 and R7 each independently represent an alkylidene group having 1 to 40 carbon atoms or an arylene group having 6 to 40 carbon atoms;
when n is 3, X represents an alkanetriyl group having 1 to 40 carbon atoms or a trivalent cyclic group having 6 to 40 carbon atoms,
when n is 4, X represents an alkanetetrayl group having 1 to 40 carbon atoms; and
wherein a methylene group in said alkyl group, alkoxy group, arylalkyl group, alkylidene group, alkanetriyl group and alkanetetrayl group is optionally substituted with >C?O, —O—, —S—, —CO—O—, —O—CO—, —O—CO—O—, —NR5—, a phosphine, a phosphinite, a phosphonite, a phosphite, a phosphorane, a phosphonate or a combination thereof and optionally branched, and R5 represents a hydrogen atom or an alkyl group having 1 to 4 carbon atoms,
wherein, in formula 2?, X forms a carbon-carbon bond with the phenyl group, and
wherein said phenolic antioxidant has a molecular weight in a range of 300 to 2,000,
wherein said phosphorus-based antioxidant is represented by Formula (4):

wherein, R8 and R9 each independently represent an alkyl group having 1 to 40 carbon atoms, R10 represents a direct bond, b is 1, and T represents an alkyl group having 1 to 40 carbon atoms; and
wherein the one or more resin additives are selected from the group consisting of thioether-based antioxidant, an ultraviolet absorber, a hindered amine-based light stabilizer, a nucleating agent, a flame retardant, a flame retardant aid, a lubricant, a filler, a metallic soap, a hydrotalcite, an antistatic agent, a pigment, a dye, and a combination thereof.

US Pat. No. 10,654,989

METHOD TO ENHANCE RELEASE OF POLYMERS FROM HOT METAL SURFACES

Rohm and Haas Company, C...

1. A method comprisingcontacting a polymer composition with a metal processing surface wherein the metal processing surface is at a temperature of equal to or greater than 90° C.,
wherein the polymer composition comprises one or more base polymers selected from the group consisting of polyvinyl halides, poly(meth)acrylics, polycarbonates, olefin-based polymers, and polystryrenes and a lubricant package which comprises at least one release agent of the following formulas
where R is an alkyl group having 6 or more carbon atoms, M is a metal or cation, and X may be absent or selected from the group consisting of aromatic groups and ester groups.

US Pat. No. 10,654,985

MICROPOROUS POLYMERIC COMPOSITION

COMMONWEALTH SCIENTIFIC A...

1. A microporous polymeric composition comprising 60% to 90% by weight of a matrix polymer selected from at least one of substituted polyacetylenes and polymers of intrinsic microporosity (PIMs) and having a fractional free volume of at least 0.1 and dispersed particles comprising 5% to 25% by weight of the microporous polymeric composition of hypercrosslinked polymer comprising optionally substituted aryl groups (Ar) covalently linked by methylene bridging groups (CH2) providing a link with repeating units —(Ar—CH2—Ar—CH2)n- wherein n is the number of repeating units.

US Pat. No. 10,654,983

POROUS FILM AND METHOD OF FORMING POROUS FILM

FUJI XEROX CO., LTD., To...

1. A porous film comprising:at least one porous polyimide film that includes a polyimide resin, an organic amine compound, and a resin other than a polyimide resin, and that does not include a polar aprotic solvent,
wherein a content of the organic amine compound is 0.001% by weight or higher with respect to a total weight of the porous polyimide film and
the shape of pores is substantially spherical.

US Pat. No. 10,654,979

AMPHIPHILIC GRAFT COPOLYMERS

Becton, Dickinson and Com...

1. A medical device formed from a blend comprising:a base polymeric formulation comprising at least a polymer or co-polymer of propylene; and
an additive comprising a polypropylene-poly(ethylene oxide)-poly(propylene oxide) amphiphilic graft copolymer (PPMA-g-PEO-PPO);
the PPMA-g-PEO-PPO being present in the blend in an amount in the range of about 0.01 to about 5.0% by weight of the blend;
wherein the PPMA-g-PEO-PPO is according to Formula (I):

wherein Me is CH3; the molar value of m is in the range from 5 to 25 mole percent; and
the molar value of n is in the range from 75 to 95 mole percent; the molar value of x is in the range from >0 to 40 propylene oxide units; and the molar value of y is in the range from >0 to 80 ethylene oxide units, and
wherein the medical device is in the form of tubing.

US Pat. No. 10,654,977

UNDERWATER SELF-HEALABLE MATERIALS, METHODS OF MAKING THEREOF, AND PRODUCTS COMPRISING SAME

CITY UNIVERSITY OF HONG K...

1. An intermediate compound of formula I,for use in manufacture of a self-healable, wherein n is from 4 to 24.

US Pat. No. 10,654,976

METHOD FOR PRODUCING A CROSS-LINKED SILOXANE NETWORK

1. A method for producing a cross-linked siloxane network, the method comprising the steps of:(a) providing a first part comprising (i) a first siloxane compound comprising at least one cyclic siloxane moiety and (ii) a second siloxane compound comprising a plurality of siloxane moieties, wherein 50 mol. % or more of the siloxane moieties in the second siloxane compound are selected from the group consisting of moieties of Formula (LXXX) and moieties of Formula (XC)
wherein R81, R82, and R91 are independently selected from the group consisting of haloalkyl groups, aralkyl groups, aryl groups, substituted aryl groups, heteroaryl groups, and substituted heteroaryl groups, wherein about 25 mol. % or more of the siloxane moieties in the second siloxane compound are moieties of Formula (XC), and wherein about 10 mol. % or more of silicon atoms in the second siloxane compound have one or more hydroxy groups covalently bound thereto; and wherein Formula (LXXX) constitutes a D unit and Formula (XC) constitutes a T unit;(b) providing a second part, the second part comprising a hydroxide salt;
(c) combining the first part and the second part to produce a reaction mixture;
(d) heating the reaction mixture to a temperature sufficient for the hydroxide salt to open the ring of the cyclic siloxane moiety; and
(e) maintaining the reaction mixture at an elevated temperature so that at least a portion of the opened cyclic siloxane moieties react to produce a cross-linked siloxane network.

US Pat. No. 10,654,971

AROMATIC POLYCARBONATE OLIGOMER SOLID

Honshu Chemical Industry ...

1. An aromatic polycarbonate oligomer solid comprising a repeating unit represented by the following general formula (1) and having a weight average molecular weight of 500 to 10000, a low molecular weight component of 5.0 area % or less as measured by high performance liquid chromatography, and a loose bulk density of 0.21 g/cm3 or more

US Pat. No. 10,654,970

CAMERA MODULE-USE LIQUID CRYSTALLINE POLYESTER RESIN COMPOSITION AND CAMERA MODULE-USE MOLDED PRODUCT FORMED THEREOF

Toray Industries, Inc., ...

1. A liquid crystalline polyester resin composition for use in camera modules, the resin composition comprising 20 to 45 parts by weight of spherical silica particles (B) having an average particle diameter of 15 ?m or more and less than 30 ?m in 100 parts by weight of a liquid crystalline polyester resin (A), wherein the liquid crystalline polyester resin (A) is composed of structural units (I), (II), (III), (IV) and (V), and wherein the content of structural unit (I) is from 65 to 80% by mole relative to the total content of structural units (I), (II) and (III), and the content of structural unit (II) is from 55 to 85% by mole relative to the total content of structural units (II) and (III), and the content of structural unit (IV) is from 50 to 95% by mole relative to the total content of structural units (IV) and (V)

US Pat. No. 10,654,969

THIN FILM AND METHOD FOR MANUFACTURING THE SAME AND COPPER CLAD LAMINATE

INDUSTRIAL TECHNOLOGY RES...

1. A thin film, comprising:a polymer formed by reacting (a) p-hydroxybenzoic acid, (b) 6-hydroxy 2-naphthoic acid and (c) branched-monomer,
wherein (c) branched-monomer is
or a combination thereof, wherein R is aryl group, heteroaryl group, or cycloalkyl group, and each of R1 is independently —OH, —NH2, or —COOH;wherein a molar ratio of (a) p-hydroxybenzoic acid over (b) 6-hydroxy 2-naphthoic acid is between 50:50 and 90:10;
wherein a molar ratio of (c) branched-monomer over the sum of (a) p-hydroxybenzoic acid and (b) 6-hydroxy 2-naphthoic acid is between 0.25:100 and 0.5:100; and
wherein the polymer has an inherent viscosity of 4 dL/g to 6 dL/g.

US Pat. No. 10,654,967

POLYMER COMPOUND AND LIGHT-EMITTING ELEMENT USING SAME

Sumitomo Chemical Company...

1. A polymer compound comprising a constitutional unit represented by the formula (1A) and a constitutional unit represented by the formula (2A):whereinRAm and RBm each independently represent a hydrogen atom, an alkyl group, a cycloalkyl group, an aryl group or a monovalent heterocyclic group, and these groups each optionally have a substituent, and when a plurality of RBm are present, they may be the same or different,
Ar1m and Ar2m each independently represent an arylene group or a divalent heterocyclic group, and these groups each optionally have a substituent, and A1m and RAm may be combined together to form a ring together with the nitrogen atom to which they are attached, and Ar2m and RBm may be combined together to form a ring together with the nitrogen atom to which they are attached,
ArM represents an aromatic hydrocarbon group or a heterocyclic group, and these groups each optionally have a substituent, and when a plurality of ArM are present, they may be the same or different,
m1, and m3 each independently represent an integer of 1 to 4,
m2 represents an integer of 0 to 5,
when a plurality of m2 and m3 are present, they may be the same or different at each occurrence,
LM represents an alkylene group, a cycloalkylene group, an arylene group, a divalent heterocyclic group, a group represented by —N(R?)—, an oxygen atom or a sulfur atom, and these groups each optionally have a substituent, and R? represents a hydrogen atom, an alkyl group, a cycloalkyl group, an aryl group or a monovalent heterocyclic group, and these groups each optionally have a substituent, and when a plurality of LM are present, they may be the same or different, and
XM represents a monovalent group containing a crosslinkable group represented by the formula (XL-9), the formula (XL-10), the formula (XL-11), the formula (XL-12), the formula (XL-13) or the formula (XL-16), and these groups each optionally have a substituent, and when a plurality of XM are present, they may be the same or different:
wherein * represents a binding site;andRAn and RBn each independently represent a hydrogen atom, an alkyl group, a cycloalkyl group, an aryl group or a monovalent heterocyclic group, and these groups each optionally have a substituent, and when a plurality of RBn are present, they may be the same or different,
Ar1n, Ar2n and ArLn each independently represent an arylene group or a divalent heterocyclic group, and these groups each optionally have a substituent, and Ar1n and RAn may be combined together to form a ring together with the nitrogen atom to which they are attached, Ar2n and RBn may be combined together to form a ring together with the nitrogen atom to which they are attached, and when a plurality ArLn is present, they may be the same or different at each occurrence,
ArN represents an aromatic hydrocarbon group or a heterocyclic group, and these groups each optionally have a substituent, and when a plurality of ArN are present, they may be the same or different,
n1 and n3 each independently represent an integer of 1 to 4,
n2 represents 1 or 2,
Ln represents an integer of 0 to 4,
LN represents an alkylene group, a cycloalkylene group, a divalent heterocyclic group, a group represented by —N(R?)—, an oxygen atom or a sulfur atom, and these groups each optionally have a substituent, and R? represents the same meaning as described above, and when a plurality of LN are present, they may be the same or different, and
XN represents a monovalent group containing a crosslinkable group represented by the formula (XL-1), the formula (XL-2), the formula (XL-3), the formula (XL-4), the formula (XL-5), the formula (XL-6), the formula (XL-7), the formula (XL-8), the formula (XL-14) or the formula (XL-15), and these groups each optionally have a substituent, and when a plurality of XN are present, they may be the same or different:
whereinnXL represents an integer of 0 to 5, and when a plurality of nXL are present, they may be the same or different,
RXL represents a methylene group, an oxygen atom or a sulfur atom, and when a plurality of RXL are present, they may be the same or different, and
* represents the same meaning as described above.

US Pat. No. 10,654,963

SOLID ELECTROLYTE COMPOSITION, BINDER FOR ALL-SOLID-STATE SECONDARY BATTERIES, AND ELECTRODE SHEET FOR BATTERIES AND ALL-SOLID-STATE SECONDARY BATTERY EACH USING SAID SOLID ELECTROLYTE COMPOSITION

FUJIFILM Corporation, To...

1. A solid electrolyte composition comprising:an inorganic solid electrolyte having conductivity of an ion of metal belong to Group 1 or 2 in the periodic table; and
a high polymer binder,
wherein the high polymer binder is formed of a polymer having a hard segment and a soft segment, and
wherein the hard segment forming the high polymer binder contains at least any one bond of an amide bond, an urea bond, an urethane bond, and an imide bond, and the polymer forming the high polymer binder has at least any one of repeating structures expressed by Formulae (II-1) to (II-5) of Group II below, as the soft segment,

in Formulae (II-1), and (II-3) to (II-5), R21 represents a hydrogen atom or an alkyl group, R22 represents a substituent group which contains a polyalkylene oxide chain, a polycarbonate chain, or a polyester chain and of which a weight average molecular weight is 200 to 200,000, R23 represents a linking group which contains a polyalkylene oxide chain, a polycarbonate chain, or a polyester chain and of which a weight average molecular weight is 200 to 200,000, and * represents a bonding position, and
in Formulae (II-2), R23 represents a linking group which contains a polycarbonate chain and of which a weight average molecular weight is 200 to 200,000, and * represents a bonding position.

US Pat. No. 10,654,960

DUAL-MECHANISM THICKENING AGENTS FOR HYDRAULIC FRACTURING FLUIDS

PILOT POLYMER TECHNOLOGIE...

1. A dual-mechanism thickening agent comprising a gel-forming star macromolecule, wherein the gel-forming star macromolecule is represented by Formula (I):
wherein:
Core represents a crosslinked polymeric segment;
P1 represents a hydrophobic polymeric segment comprised predominantly of repeat units of monomeric residues of polymerized hydrophobic monomers;
P2 represents a hydrophilic polymeric segment comprised predominantly of repeat units of monomeric residues of polymerized hydrophilic monomers;
P3 represents a hydrophilic polymeric segment comprised predominantly of repeat units of monomeric residues of polymerized hydrophilic monomers;
P4 represents a hydroxyl-containing segment (homopolymeric or copolymeric) comprised of repeat units of monomeric residues, where at least one of the monomeric residues or a plurality of the monomeric residues is a hydroxyl-containing monomeric residue, of polymerized monomers;
P5 represents a hydrophilic polymeric segment comprised predominantly of repeat units of monomeric residues of polymerized hydrophilic monomers;
q1 represents the number of repeat units in P1 and has a value between 1 and 50;
q2 represents the number of repeat units in P2 and has a value between 30 and 2000;
q3 represents the number of repeat units in P3 and has a value between 30 and 2000;
q4 represents the number of repeat units in P4 and has a value between 1 and 50;
q5 represents the number of repeat units in P5 and has a value between 30 and 2000;
r represents the number of polymeric arms covalently attached to the Core;
s represents the number of hydroxyl-containing arms covalently attached to the Core; and
t represents the number of hydrophobic-containing copolymeric arms covalently attached to the Core and has a value of 1 or more.

US Pat. No. 10,654,957

METHOD FOR MANUFACTURING COPOLYMER AND RUBBER COMPOSITION CONTAINING THE SAME

Korea Kumho Petrochemical...

1. A method of preparing a copolymer, the method comprising:(a) polymerizing an aromatic vinyl monomer and a conjugated diene-based monomer with a solvent, a first randomizing agent, and a catalyst to prepare a first copolymer including the aromatic vinyl monomer in an amount of 15 to 40 wt %; and
(b) reacting the first copolymer with one or more of a second randomizing agent different from the first randomizing agent and an additional aromatic vinyl monomer to prepare a second copolymer.

US Pat. No. 10,654,956

ETHYLENE ALPHA-OLEFIN COPOLYMERS AND METHODS

Equistar Chemicals, LP, ...

1. An ethylene alpha-olefin copolymer comprising:an ethylene monomer; and
an alpha-olefin monomer;
wherein the ethylene alpha-olefin copolymer comprises—
(i) a density of about 0.915 g/mL to about 0.918 g/mL,
(ii) a rheological polydispersity index greater than 0.8,
(iii) a melt index of about 0.4 dg/10 min to about 2.0 dg/10 min, and
(iv) a CEF T50 of 84° C. or less.

US Pat. No. 10,654,955

ETHYLENE-BASED POLYMERS COMPRISING UNITS DERIVED FROM CARBON MONOXIDE AND A RHEOLOGY MODIFYING AGENT

Dow Global Technologies L...

1. A composition comprising an ethylene-based polymer, comprising at least the following:A) a unit derived from Carbon Monoxide (CO); and
B) a unit derived from at least one Rheology Modifying Agent (RMA) selected from the following i) through vi):
i) RMA 1:

wherein, for RMA1, R1 is H or alkyl,
n is from 1 to 50,
R2 is selected from H or an alkyl,
R3 is selected from H or an alkyl;
ii) RMA2:

wherein, for RMA2, R4 and R5 are each independently H or an alkyl,
m is from 1 to 50;
iii) RMA3:

wherein, for RMA3, R6 and R9 are each independently H or an alkyl,
p is from 1 to 50;
R7 is selected from H or an alkyl,
R8 is selected from H or an alkyl;
iv) RMA4:

wherein R10 is hydrogen or an alkyl,
the notation “” is a hydrocarbon chain comprising from 2 to 50 carbon atoms, and wherein the hydrocarbon chain is linear, branched, or comprises a saturated hydrocarbon ring structure;
v) RMA5

wherein q is from 2 to 20; R11 is selected from H or alkyl; R12 is selected from H or alkyl; R13 is selected from H or alkyl; R14 is selected from H or alkyl; or
vi) any combination of i) through v).

US Pat. No. 10,654,952

NITROGEN TITANIUM COMPLEX, CATALYTIC SYSTEM COMPRISING SAID NITROGEN TITANIUM COMPLEX AND PROCESS FOR THE (CO)POLYMERIZATION OF CONJUGATED DIENES

Versalis S.P.A., San Don...

1. A nitrogen titanium complex having general formula (I):wherein:R1 represents a hydrogen atom; or is selected from linear or branched C1-C20 alkyl groups, optionally halogenated, cycloalkyl groups optionally substituted or aryl groups optionally substituted;
R2, R3, R4 and R5, identical or different, represent a hydrogen atom; or are selected from linear or branched C1-C20 alkyl groups, optionally halogenated, cycloalkyl groups optionally substituted, aryl groups optionally substituted, nitro groups, hydroxyl groups or amino groups;
Y represents a NH—R6 group wherein R6 represents a hydrogen atom, or is selected from linear or branched C1-C20 alkyl groups, optionally halogenated, cycloalkyl groups optionally substituted or aryl groups optionally substituted; or a N—R7 group wherein R7 is selected from linear or branched C1-C20 alkyl groups, optionally halogenated, cycloalkyl groups optionally substituted or aryl groups optionally substituted;
X1, X2, X3 and X4, identical or different, represent a halogen atom; or are selected from linear or branched C1-C20 alkyl groups, —OCOR8 groups or groups —OR8 wherein R8 is selected from linear or branched C1-C20 alkyl groups; or one of X1, X2 and X3 is selected from ethers; and
n is 1 in the case wherein Y represents a NH—R6 group wherein R6 has the same meanings reported above; or n is 0 in the case wherein Y represents a N—R7 group wherein R7 has the same meanings reported above, or n is 0 in the case wherein one of X1, X2 and X3 is selected from ethers.

US Pat. No. 10,654,950

VINYL CHLORIDE-BASED POLYMER, METHOD OF PREPARING THE SAME, AND PLASTISOL INCLUDING THE POLYMER

LG CHEM LTD., Seoul (KR)...

1. A vinyl chloride-based polymer, with a particle size distribution which represents a weight ratio of polymer particles belonging to a certain particle diameter range to total polymer particles,wherein 65 wt % to 80 wt % of the weight of the total polymer particles has a particle diameter of 0.1 ?m to 0.29 ?m,
wherein 20 wt % to 35 wt % of the weight of the total polymer particles has a particle diameter of 0.3 ?m to 3.0 ?m,
wherein the polymer particles having a particla diameter of 0.3 ?m to 3.0 ?m comprise polymer particles having a particle diameter of 1.0 ?m to 3.0 ?m, and
wherein the polymer has a peak particle diameter (Dp) of 0.17 ?m to 0.29 ?m.

US Pat. No. 10,654,946

CATALYST COMPONENTS FOR THE POLYMERIZATION OF OLEFINS

Basell Poliolefine Italia...

1. A solid catalyst component for the polymerization of olefins comprising:Mg, Ti and an electron donor of formula (I)
whereinR1 and R7 groups, equal to or different from each other, are selected from C1-C15 hydrocarbon groups,
R2 group is selected from C1-C10 hydrocarbon groups, and
R3 to R6 groups, independently, are selected from hydrogen or C1-C15 hydrocarbon groups which can be fused together to form one or more cycles.

US Pat. No. 10,654,913

FIBRONECTIN TYPE III DOMAIN BASED SCAFFOLD COMPOSITIONS, METHODS AND USES

Janssen Biotech, Inc., H...

1. A library produced by a method of constructing a library of a protein scaffold based on a fibronectin type III (FN3) domain derived from a consensus sequence of an FN3 domain, comprising the steps of:providing a polypeptide derived from a consensus sequence of an FN3 domain having at least 90% identity to the amino acid sequence of SEQ ID NO:16; and
introducing diversity into copies of the polypeptide to form the protein scaffold library.

US Pat. No. 10,654,884

PURINE DERIVATIVES AS CD73 INHIBITORS FOR THE TREATMENT OF CANCER

Boehringer Ingelheim Inte...

1. A compound of Formula Ia:or a pharmaceutically acceptable salt thereof, wherein:Hy is selected from:

A is O, S, NRf, or CH2;
W is O or S;
X is C1-4 haloalkyl, —C(O)OR3, —C(O)NR4R5, —CH2OR3, —S(O)2R6, —P(O)(OR7)(OR8), or a 5-6 membered heteroaryl group optionally substituted with 1, 2, or 3 substituents independently selected from halo, CN, OH, C1-4 alkyl, C1-4 alkoxy, NH2, NH(C1-4 alkyl), N(C1-4 alkyl)2, C(O)(C1-4 alkyl), C(O)NH2, C(O)NH(C1-4 alkyl), C(O) N(C1-4 alkyl)2, C(O)OH, or C(O)O(C1-4 alkyl);
Y is H, Cy1, C1-4 alkyl, or —C(O)OR9, wherein said C1-4 alkyl is optionally substituted by 1, 2, or 3 substituents independently selected from Cy1, halo, C1-4 haloalkyl, CN, NO2, ORa1, SRa1, C(O)Rb1, C(O)NRc1Rd1, C(O)ORa1, OC(O)Rb1, OC(O)NRc1Rd1, NRc1Rd1, NRc1C(O)Rb1, NRc1C(O)ORa1, NRc1C(O)NRc1Rd1, NRc1S(O)Rb1, NRc1S(O)2Rb1, NRc1S(O)2NRc1Rd1, S(O)Rb1, S(O)NRc1Rd1, S(O)2Rb1, or S(O)2NRc1Rd1;
Z is —C(O)OR10 or —P(O)(OR11)(OR12);
R1 and R2 are both H;
R3 is H, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C6-10 aryl, C3-10 cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C6-10 aryl-C1-4 alkyl, C3-10 cycloalkyl-C1-4 alkyl, (5-10 membered heteroaryl)-C1-4 alkyl, and (4-10 membered heterocycloalkyl)-C1-4 alkyl, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C6-10 aryl, C3-10 cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C6-10 aryl-C1-4 alkyl, C3-10 cycloalkyl-C1-4 alkyl, (5-10 membered heteroaryl)-C1-4 alkyl, and (4-10 membered heterocycloalkyl)-C1-4 alkyl are each optionally substituted with 1, 2, 3, or 4 substituents independently selected from halo, C1-4 alkyl, C1-4 haloalkyl, CN, NO2, ORa2, SRa2, C(O)Rb2, C(O)NRc2Rd2, C(O)ORa2, OC(O)Rb2, OC(O)NRc2Rd2, NRc2Rd2, NRc2C(O)Rb2, NRc2C(O)ORa2, NRc2C(O)NRc2Rd2, NRc2S(O)Rb2, NRc2S(O)2Rb2 NRc2S(O)2NRc2Rd2, S(O)Rb2, S(O)NRc2Rd2, S(O)2Rb2, or S(O)2NRc2Rd2;
R4 and R5 are each independently selected from H, —NRARB, —ORC, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C6-10 aryl, C3-10 cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C6-10 aryl-C1-4 alkyl, C3-10 cycloalkyl-C1-4 alkyl, (5-10 membered heteroaryl)-C1-4 alkyl, or (4-10 membered heterocycloalkyl)-C1-4 alkyl, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C6-10 aryl, C3-10 cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C6-10 aryl-C1-4 alkyl, C3-10 cycloalkyl-C1-4 alkyl, (5-10 membered heteroaryl)-C1-4 alkyl, or (4-10 membered heterocycloalkyl)-C1-4 alkyl are each optionally substituted with 1, 2, 3, or 4 substituents independently selected from halo, C1-4 alkyl, C1-4 haloalkyl, CN, NO2, ORa3, SRa3, C(O)Rb3, C(O)NRc3Rd3, C(O)ORa3, OC(O)Rb3, OC(O)NRc3Rd3, NRc3Rd3, NRc3C(O)Rb3, NRc3C(O)OR, NRc3C(O)NRc3Rd3, NRc3S(O)Rb3, NRc3S(O)2Rb3, NRc3S(O)2NRc3Rd3, S(O)Rb3, S(O)NRc3Rd3, S(O)2Rb3, or S(O)2NRc3Rd3;
R6 is C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C6-10 aryl, C3-10 cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C6-10 aryl-C1-4 alkyl, C3-10 cycloalkyl-C1-4 alkyl, (5-10 membered heteroaryl)-C1-4 alkyl, or (4-10 membered heterocycloalkyl)-C1-4 alkyl;
R7 and R8 are each independently selected from H or C1-6 alkyl optionally substituted by 1, 2, or 3 substituents independently selected from halo, CN, OR4, SR4, C(O)Rb4, C(O)NRc4Rd4, C(O)ORa4, OC(O)Rb4, OC(O)NRc4Rd4, NRc4Rd4, NRc4C(O)Rb4, NRc4C(O)ORa4, NRc4C(O)NRc4Rd4, NRc4S(O)Rb4, NRc4S(O)2Rb4, NRc4S(O)2NRc4Rd4, S(O)Rb4, S(O)NRc4Rd4, S(O)2Rb4, or S(O)2NRc4Rd4;
R9 is H or C1-4 alkyl;
R10 is H, C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C1-6 haloalkyl, C6-10 aryl, C3-10 cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C6-10 aryl-C1-4 alkyl, C3-10 cycloalkyl-C1-4 alkyl, (5-10 membered heteroaryl)-C1-4 alkyl, or (4-10 membered heterocycloalkyl)-C1-4 alkyl, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C6-10 aryl, C3-10 cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C6-10 aryl-C1-4 alkyl, C3-10 cycloalkyl-C1-4 alkyl, (5-10 membered heteroaryl)-C1-4 alkyl, or (4-10 membered heterocycloalkyl)-C1-4 alkyl are each optionally substituted with 1, 2, 3, or 4 substituents independently selected from halo, C1-4 alkyl, C1-4 haloalkyl, CN, NO2, ORa5, SRa5, C(O)Rb5, C(O)NRc5Rd5, C(O)ORa5, OC(O)Rb5, OC(O)NRc5Rd5, NRc5Rd5 NRc5C(O)Rb5, NRc5C(O)ORa5, NRc5C(O)NRc5Rd5, NRc5S(O)Rb5, NRc5S(O)2Rb5, NRc5S(O)2NRc5Rd5, S(O)Rb5, S(O)NRc5Rd5, S(O)2Rb5, or S(O)2NRc5Rd5;
R11 and R12 are each independently selected from H or C1-6 alkyl optionally substituted by 1, 2, or 3 substituents independently selected from halo, CN, ORa6, SRa6, C(O)Rb6, C(O)NRc6Rd6, C(O)ORa6, OC(O)Rb6, OC(O)NRc6Rd6, NRc6Rd6, NRc6C(O)Rb6, NRc6C(O)ORa6, NRc6C(O)NRc6Rd6, NRc6S(O)Rb6, NRc6S(O)2Rb6, NRc6S(O)2NRc6Rd6, S(O)Rb6, S(O)NRc6Rd6, S(O)2Rb6, or S(O)2NRc6Rd6;
RA is H or C1-6 alkyl;
RB is C1-6 alkyl or —C(O)(C1-6 alkyl);
RC is H or C1-6 alkyl;
Ra is Cy2, H, halo, C1-4 alkyl, NRc7Rd7, or NRc7C(O)Rb7, wherein said C1-4 alkyl is optionally substituted by Cy2;
Rb is H or halo;
Rc is Cy2, halo, C1-4 alkyl, C1-4 haloalkyl, CN, ORa7, SRa7, C(O)Rb7, C(O)NRc7Rd7, C(O)ORa7, OC(O)Rb7, OC(O)NRc7Rd7, NRc7Rd7, NRc7C(O)Rb7, NRc7C(O)ORa7, NRc7C(O)NRc7Rd7, NRc7S(O)Rb7, NRc7S(O)2Rb7, NRc7S(O)2NRc7Rd7, S(O)Rb7, S(O)NRc7Rd7, S(O)2Rb7, or S(O)2NRc7Rd7, wherein said C1-4 alkyl is optionally substituted by 1, 2, or 3 substituents independently selected from Cy2, H, halo, C1-4 haloalkyl, CN, ORa7, SRa7, C(O)Rb7, C(O)NRc7Rd7, C(O)ORa7, OC(O)Rb7, OC(O)NRc7Rd7, NRc7Rd7, NRc7C(O)Rb7, NRc7C(O)ORa7, NRc7C(O)NRc7Rd7 NRc7S(O)Rb7, NRc7S(O)2Rb7, NRc7S(O)2NRc7Rd7, S(O)Rb7, S(O)NRc7Rd7, S(O)2Rb7, or S(O)2NRc7Rd7;
Rd is halo or CN;
Re selected from H, halo, or C1-4 alkyl;
Rf is H, C1-4 alkyl, or —C(O)(C1-4 alkyl);
each Cy1 and Cy2 are independently selected from C6-10 aryl, C3-10 cycloalkyl, 5-10 membered heteroaryl, or 4-10 membered heterocycloalkyl, each of which is substituted with 1, 2, 3, or 4 substituents independently selected from halo, C1-4 alkyl, C1-4 haloalkyl, C1-4 cyanoalkyl, CN, NO2, ORa8, SRa8, C(O)Rb8, C(O)NRc8Rd8, C(O)ORa8, OC(O)Rb8, OC(O)NRc8Rd8, NRc8Rd8, NRc8C(O)Rb8, NRc8C(O)ORa8, NRc8C(O)NRc8Rd8, NRc8S(O)Rb8, NRc8S(O)2Rb8, NRc8S(O)2NRc8Rd8, S(O)Rb8, S(O)NRc8Rd8, S(O)2Rb8, or S(O)2NRc8Rd8;
each Ra1, Rb1, Rc1, Rd1, Ra2, Rb2, Rc2, Rd2, Ra3, Rb3, Rc3, Rd3, Ra4, Rb4, Rc4, Rd4, Ra5, Rb5, Rc5, Rd5, Ra6, Rb6, Rc6, Rd6, Ra7, Rb7, Rc7, Rd7, Ra8, Rb8, Rc8, and Rd8 is independently selected from H, C1-6 alkyl, C1-4 haloalkyl, C2-6 alkenyl, C2-6 alkynyl, C6-10 aryl, C3-10 cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C6-10 aryl-C1-4 alkyl-, C3-10 cycloalkyl-C1-4 alkyl-, (5-10 membered heteroaryl)-C1-4 alkyl-, or (4-10 membered heterocycloalkyl)-C1-4 alkyl-, wherein said C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C6-10 aryl, C3-10 cycloalkyl, 5-10 membered heteroaryl, 4-10 membered heterocycloalkyl, C6-10 aryl-C1-4 alkyl-, C3-10 cycloalkyl-C1-4 alkyl-, (5-10 membered heteroaryl)-C1-4 alkyl-, and (4-10 membered heterocycloalkyl)-C1-4 alkyl- is optionally substituted with 1, 2, 3, 4, or 5 substituents independently selected from C1-4 alkyl, C1-4 haloalkyl, C1-4 cyanoalkyl, halo, CN, ORa9, SRa9, C(O)Rb9, C(O)NRc9Rd9, C(O)ORa9, OC(O)Rb9, OC(O)NRc9Rd9, NRc9Rd9, NRc9C(O)Rb9, NRc9C(O)NRc9Rd9, NRc9C(O)ORa9, S(O)Rb9, S(O)NRc9Rd9, S(O)2Rb9, NRc9S(O)2Rb9, NRc9S(O)2NRc9Rd9, or S(O)2NRc9Rd9;
or any Rc1 and Rd1 together with the N atom to which they are attached form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, or 3 substituents independently selected from C1-6 alkyl, C3-7 cycloalkyl, 4-7 membered heterocycloalkyl, C6-10 aryl, 5-6 membered heteroaryl, C1-6 haloalkyl, halo, CN, ORa9, SRa9, C(O)Rb9, C(O)NRc9Rd9, C(O)ORa9, OC(O)Rb9, OC(O)NRc9Rd9, NRc9Rd9, NRc9C(O)Rb9, NRc9C(O)NRc9Rd9, NRc9C(O)ORa9, S(O)Rb9, S(O)NRc9Rd9, S(O)2Rb9, NRc9S(O)2Rb9, NRc9S(O)2NRc9Rd9, or S(O)2NRc9Rd9, wherein said C1-6 alkyl, C3-7 cycloalkyl, 4-7 membered heterocycloalkyl, C6-10 aryl, and 5-6 membered heteroaryl are optionally substituted by 1, 2, or 3 substituents independently selected from halo, C1-4 alkyl, C1-4 haloalkyl, C1-4 cyanoalkyl, CN, ORa9, SRa9, C(O)Rb9, C(O)NRc9Rd9, C(O)ORa9, OC(O)Rb9, OC(O)NRc9Rd9, NRc9Rd9, NRc9C(O)Rb9, NRc9C(O)NRc9Rd9, NRc9C(O)ORa9, S(O)Rb9, S(O)NRc9Rd9, S(O)2Rb9, NRc9S(O)2Rb9, NRc9S(O)2NRc9Rd9, or S(O)2NRc9Rd9;
or any Rc2 and Rd2 together with the N atom to which they are attached form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, or 3 substituents independently selected from C1-6 alkyl, C3-7 cycloalkyl, 4-7 membered heterocycloalkyl, C6-10 aryl, 5-6 membered heteroaryl, C1-6 haloalkyl, halo, CN, ORa9, SRa9, C(O)Rb9, C(O)NRc9Rd9, C(O)ORa9, OC(O)Rb9, OC(O)NRc9Rd9, NRc9Rd9, NRc9C(O)Rb9, NRc9C(O)NRc9Rd9, NRc9C(O)ORa9, S(O)Rb9, S(O)NRc9Rd9, S(O)2Rb9, NRc9S(O)2Rb9, NRc9S(O)2NRc9Rd9, or S(O)2NRc9Rd9, wherein said C1-6 alkyl, C3-7 cycloalkyl, 4-7 membered heterocycloalkyl, C6-10 aryl, and 5-6 membered heteroaryl are optionally substituted by 1, 2, or 3 substituents independently selected from halo, C1-4 alkyl, C1-4 haloalkyl, C1-4 cyanoalkyl, CN, ORa9, SRa9, C(O)Rb9, C(O)NRc9Rd9, C(O)ORa9, OC(O)Rb9, OC(O)NRc9Rd9, NRc9Rd9, NRc9C(O)Rb9, NRc9C(O)NRc9Rd9, NRc9C(O)ORa9, S(O)Rb9, S(O)NRc9Rd9, S(O)2Rb9, NRc9S(O)2Rb9, NRc9S(O)2NRc9Rd9, or S(O)2NRc9Rd9;
or any Rc3 and Rd3 together with the N atom to which they are attached form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, or 3 substituents independently selected from C1-6 alkyl, C3-7 cycloalkyl, 4-7 membered heterocycloalkyl, C6-10 aryl, 5-6 membered heteroaryl, C1-6 haloalkyl, halo, CN, ORa9, SRa9, C(O)Rb9, C(O)NRc9Rd9, C(O)ORa9, OC(O)Rb9, OC(O)NRc9Rd9, NRc9Rd9, NRc9C(O)Rb9, NRc9C(O)NRc9Rd9, NRc9C(O)ORa9, S(O)Rb9, S(O)NRc9Rd9, S(O)2Rb9, NRc9S(O)2Rb9, NRc9S(O)2NRc9Rd9, or S(O)2NRc9Rd9, wherein said C1-6 alkyl, C3-7 cycloalkyl, 4-7 membered heterocycloalkyl, C6-10 aryl, and 5-6 membered heteroaryl are optionally substituted by 1, 2, or 3 substituents independently selected from halo, C1-4 alkyl, C1-4 haloalkyl, C1-4 cyanoalkyl, CN, ORa9, SRa9, C(O)Rb9, C(O)NRc9Rd9, C(O)ORa9, OC(O)Rb9, OC(O)NRc9Rd9, NRc9Rd9, NRc9C(O)Rb9, NRc9C(O)NRc9Rd9, NRc9C(O)ORa9, S(O)Rb9, S(O)NRc9Rd9, S(O)2Rb9, NRc9S(O)2Rb9, NRc9S(O)2NRc9Rd9, or S(O)2NRc9Rd9;
or any Rc4 and Rd4 together with the N atom to which they are attached form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, or 3 substituents independently selected from C1-6 alkyl, C3-7 cycloalkyl, 4-7 membered heterocycloalkyl, C6-10 aryl, 5-6 membered heteroaryl, C1-6 haloalkyl, halo, CN, ORa9, SRa9, C(O)Rb9, C(O)NRc9Rd9, C(O)ORa9, OC(O)Rb9, OC(O)NRc9Rd9, NRc9Rd9, NRc9C(O)Rb9, NRc9C(O)NRc9Rd9, NRc9C(O)ORa9, S(O)Rb9, S(O)NRc9Rd9, S(O)2Rb9, NRc9S(O)2Rb9, NRc9S(O)2NRc9Rd9, or S(O)2NRc9Rd9, wherein said C1-6 alkyl, C3-7 cycloalkyl, 4-7 membered heterocycloalkyl, C6-10 aryl, and 5-6 membered heteroaryl are optionally substituted by 1, 2, or 3 substituents independently selected from halo, C1-4 alkyl, C1-4 haloalkyl, C1-4 cyanoalkyl, CN, ORa9, SRa9, C(O)Rb9, C(O)NRc9Rd9, C(O)ORa9, OC(O)Rb9, OC(O)NRc9Rd9, NRc9Rd9, NRc9C(O)Rb9, NRc9C(O)NRc9Rd9, NRc9C(O)ORa9, S(O)Rb9, S(O)NRc9Rd9, S(O)2Rb9, NRc9S(O)2Rb9, NRc9S(O)2NRc9Rd9, or S(O)2NRc9Rd9;
or any Rc5 and Rd5 together with the N atom to which they are attached form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, or 3 substituents independently selected from C1-6 alkyl, C3-7 cycloalkyl, 4-7 membered heterocycloalkyl, C6-10 aryl, 5-6 membered heteroaryl, C1-6 haloalkyl, halo, CN, ORa9, SRa9, C(O)Rb9, C(O)NRc9Rd9, C(O)ORa9, OC(O)Rb9, OC(O)NRc9Rd9, NRc9Rd9, NRc9C(O)Rb9, NRc9C(O)NRc9Rd9, NRc9C(O)ORa9, S(O)Rb9, S(O)NRc9Rd9, S(O)2Rb9, NRc9S(O)2Rb9, NRc9S(O)2NRc9Rd9, or S(O)2NRc9Rd9, wherein said C1-6 alkyl, C3-7 cycloalkyl, 4-7 membered heterocycloalkyl, C6-10 aryl, and 5-6 membered heteroaryl are optionally substituted by 1, 2, or 3 substituents independently selected from halo, C1-4 alkyl, C1-4 haloalkyl, C1-4 cyanoalkyl, CN, ORa9, SRa9, C(O)Rb9, C(O)NRc9Rd9, C(O)ORa9, OC(O)Rb9, OC(O)NRc9Rd9, NRc9Rd9, NRc9C(O)Rb9, NRc9C(O)NRc9Rd9, NRc9C(O)ORa9, S(O)Rb9, S(O)NRc9Rd9, S(O)2Rb9, NRc9S(O)2Rb9, NRc9S(O)2NRc9Rd9, or S(O)2NRc9Rd9;
or any Rc6 and Rd6 together with the N atom to which they are attached form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, or 3 substituents independently selected from C1-6 alkyl, C3-7 cycloalkyl, 4-7 membered heterocycloalkyl, C6-10 aryl, 5-6 membered heteroaryl, C1-6 haloalkyl, halo, CN, ORa9, SRa9, C(O)Rb9, C(O)NRc9Rd9, C(O)ORa9, OC(O)Rb9, OC(O)NRc9Rd9, NRc9Rd9, NRc9C(O)Rb9, NRc9C(O)NRc9Rd9, NRc9C(O)ORa9, S(O)Rb9, S(O)NRc9Rd9, S(O)2Rb9, NRc9S(O)2Rb9, NRc9S(O)2NRc9Rd9, or S(O)2NRc9Rd9, wherein said C1-6 alkyl, C3-7 cycloalkyl, 4-7 membered heterocycloalkyl, C6-10 aryl, and 5-6 membered heteroaryl are optionally substituted by 1, 2, or 3 substituents independently selected from halo, C1-4 alkyl, C1-4 haloalkyl, C1-4 cyanoalkyl, CN, ORa9, SRa9, C(O)Rb9, C(O)NRc9Rd9, C(O)ORa9, OC(O)Rb9, OC(O)NRc9Rd9, NRc9Rd9, NRc9C(O)Rb9, NRc9C(O)NRc9Rd9, NRc9C(O)ORa9, S(O)Rb9, S(O)NRc9Rd9, S(O)2Rb9, NRc9S(O)2Rb9, NRc9S(O)2NRc9Rd9, or S(O)2NRc9Rd9;
or any Rc7 and Rd7 together with the N atom to which they are attached form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, or 3 substituents independently selected from C1-6 alkyl, C3-7 cycloalkyl, 4-7 membered heterocycloalkyl, C6-10 aryl, 5-6 membered heteroaryl, C1-6 haloalkyl, halo, CN, ORa9, SRa9, C(O)Rb9, C(O)NRc9Rd9, C(O)ORa9, OC(O)Rb9, OC(O)NRc9Rd9, NRc9Rd9, NRc9C(O)Rb9, NRc9C(O)NRc9Rd9, NRc9C(O)ORa9, S(O)Rb9, S(O)NRc9Rd9, S(O)2Rb9, NRc9S(O)2Rb9, NRc9S(O)2NRc9Rd9, or S(O)2NRc9Rd9, wherein said C1-6 alkyl, C3-7 cycloalkyl, 4-7 membered heterocycloalkyl, C6-10 aryl, and 5-6 membered heteroaryl are optionally substituted by 1, 2, or 3 substituents independently selected from halo, C1-4 alkyl, C1-4 haloalkyl, C1-4 cyanoalkyl, CN, ORa9, SRa9, C(O)Rb9, C(O)NRc9Rd9, C(O)ORa9, OC(O)Rb9, OC(O)NRc9Rd9, NRc9Rd9, NRc9C(O)Rb9, NRc9C(O)NRc9Rd9, NRc9C(O)ORa9, S(O)Rb9, S(O)NRc9Rd9, S(O)2Rb9, NRc9S(O)2Rb9, NRc9S(O)2NRc9Rd9, or S(O)2NRc9Rd9;
or any Rc8 and Rd8 together with the N atom to which they are attached form a 4-, 5-, 6-, or 7-membered heterocycloalkyl group optionally substituted with 1, 2, or 3 substituents independently selected from C1-6 alkyl, C3-7 cycloalkyl, 4-7 membered heterocycloalkyl, C6-10 aryl, 5-6 membered heteroaryl, C1-6 haloalkyl, halo, CN, ORa9, SRa9, C(O)Rb9, C(O)NRc9Rd9, C(O)ORa9, OC(O)Rb9, OC(O)NRc9Rd9, NRc9Rd9, NRc9C(O)Rb9, NRc9C(O)NRc9Rd9, NRc9C(O)ORa9, S(O)Rb9, S(O)NRc9Rd9, S(O)2Rb9, NRc9S(O)2Rb9, NRc9S(O)2NRc9Rd9, or S(O)2NRc9Rd9, wherein said C1-6 alkyl, C3-7 cycloalkyl, 4-7 membered heterocycloalkyl, C6-10 aryl, and 5-6 membered heteroaryl are optionally substituted by 1, 2, or 3 substituents independently selected from halo, C1-4 alkyl, C1-4 haloalkyl, C1-4 cyanoalkyl, CN, ORa9, SRa9, C(O)Rb9, C(O)NRc9Rd9, C(O)ORa9, OC(O)Rb9, OC(O)NRc9Rd9, NRc9Rd9, NRc9C(O)Rb9, NRc9C(O)NRc9Rd9, NRc9C(O)ORa9, S(O)Rb9, S(O)NRc9Rd9, S(O)2Rb9, NRc9S(O)2Rb9, NRc9S(O)2NRc9Rd9, or S(O)2NRc9Rd9; and
each Ra9, Rb9, Rc9, and Rd9 is independently selected from H, C1-4 alkyl, C1-4 haloalkyl, C2-4 alkenyl, and C2-4 alkynyl, wherein said C1-4 alkyl, C2-4 alkenyl, and C2-4 alkynyl, is optionally substituted with 1, 2, or 3 substituents independently selected from OH, CN, amino, halo, C1-4 alkyl, C1-4 alkoxy, C1-4 alkylthio, C1-4 alkylamino, di(C1-4 alkyl)amino, C1-4 haloalkyl, or C1-4 haloalkoxy.

US Pat. No. 10,654,883

INORGANIC SALTS OF NICOTINIC ACID MONONUCLEOTIDE AS ANTI-AGING AGENTS

Jumpstart Fertility Pty L...

1. A salt selected from the group consisting of:

US Pat. No. 10,654,882

NICOTINAMIDE MONONUCLEOTIDE DERIVATIVE AND SALT THEREOF, METHOD FOR PRODUCING SAME, TOPICAL SKIN PREPARATION, COSMETIC AND FOOD ADDITIVE

SHOWA DENKO K.K., Tokyo ...

1. A nicotinamide mononucleotide derivative, or salt thereof, which is a compound represented by general formula (1):
wherein, R1 and R2 respectively and independently represent a hydrogen atom or an acyl group having 3 to 30 carbon atoms, wherein the hydrocarbon group bound to the carbonyl carbon of the acyl group is a linear or branched, saturated or unsaturated hydrocarbon group, and at least one of R1 and R2 is an acyl group.

US Pat. No. 10,654,880

METHODS FOR PREPARATION OF GLYCOSPHINGOLIPIDS AND USES THEREOF

1. A method for preparing a chiral compound comprising an R-form or S-form of a compound of formula (5):
or a pharmaceutically acceptable salt thereof, via alpha-glycosylation, the method comprising reacting a compound of formula (6):

or pharmaceutically acceptable salt thereof,
wherein PG is a hydroxyl protecting group and LG is the following:

with a compound of formula (7):

or pharmaceutically acceptable salt thereof,
in the presence of Lewis acid, to obtain a compound of formula (5), or pharmaceutically acceptable salt thereof.

US Pat. No. 10,654,879

NICKEL-BASED CATALYSTS FOR C=O REDUCTION AND OXYGEN EVOLUTION

UNIVERSITY OF SOUTHERN CA...

1. A compound having formula I:
wherein:
M is a transition metal;
X1, X2 are each independently a counterion; and
R1, R2, R3 are each independently H, C1-6 alkyl, C6-15 aryl, or C6-15 heteroaryl.

US Pat. No. 10,654,876

TH-302 SOLID FORMS AND METHODS RELATED THERETO

Molecular Templates, Inc....

1. A process for preparing a compound of Formula V:
comprising
reacting a compound of Formula II with a reducing agent in a base followed by adding an acid to provide a compound of Formula III:

and
reacting a compound of Formula III with a trisubstituted phosphine, an oxidizing agent and a phosphorus containing compound having the formula IV:

to provide a compound of Formula V.

US Pat. No. 10,654,875

CELL-PENETRATING, GUANIDINIUM-RICH OLIGOPHOSPHOTRIESTERS FOR DRUG AND PROBE DELIVERY

The Board of Trustees of ...

1. A transporter compound of the formula:wherein:Z1 is a cargo moiety, a reactive functional group or a protected functional group;
L1 is an optional linker;
X is O, S or NH;
L2 is a linker;
Z2 is an guanidine group or a protected guanidine group;
R3 is H, an alkyl, a substituted alkyl, an acyl, a substituted acyl, an aryl, a substituted aryl, a heteroaryl or a substituted heteroaryl;
R1 and R2 are independently H, an alkyl or a substituted alkyl;each p is independently 1, 2 or 3; andm is between 2 and 50.

US Pat. No. 10,654,873

CYTOTOXIC AGENTS AND CONJUGATES THEREOF

POLYTHERICS LIMITED, Cam...

1. A compound of the general formula I or a salt thereof:
in which R represents a group —Y—OH, —Y—O—Rx, —Y—SH, —Y—S—Rx, —Y—S(O)2NH—Rx, —Y—NHS(O)2—Rx, —Y—C(O)H, —Y—CO2H, —Y—C(O)—Rx, —Y—C(O)NH—Rx, —Y—NHC(O)—Rx, —Y—NHRy, —Y—NRxRy, —Y—NRy—NHRz, —Y—CRy?NOH, —Y—C(NH2)?NOH, —Y—C(O)NH2, —Y—C(O)NH—NH2, or —Y—S(O)2NH2, in which either Y is not present or Y represents a C1-6alkylene, C2-6alkenylene, C2-6alkynylene or C1-6alkyleneoxy group which may be interrupted by an oxygen atom and/or which may optionally be substituted by —OH or —OC1-4alkyl, or Y represents a phenylene or C5-10heteroarylene group;
Rx represents a C1-6alkyl, C2-6alkenyl, C2-6alkynyl, phenyl, C5-10heteroaryl or benzyl group which is substituted by —OH, —SH, —NHRy, or —CO2H;
each of Ry and Rz independently represents a hydrogen atom, a C1-4alkyl group, phenyl, C5-10heteroaryl or a benzyl group;
X represents OH, OC1-4alkyl, SH, S1-4alkyl, or CN;
Ra represents a hydrogen atom or a C1-4alkyl group;
Rb represents hydrogen, OH, C1-4alkoxy or C1-4alkylC(O)O—;
Rc represents hydrogen, OH, C1-4alkoxy or C1-4alkylC(O)O—;
Rd represents a C1-4alkyl group;
each Re independently represents a halogen atom, an optionally substituted C1-6alkyl, C2-6alkenyl, C2-6alkynyl or C1-6alkoxy group each of which may be optionally interrupted by an oxygen atom, an optionally substituted phenyl or C5-10heteroaryl group, —OH, —CO2Rv, —C(O)NRvRw, —NRyC(O)Rw, NRvRw, —S(O)—Rv, S(O)2—Rv, —S(O)2NRvRw, a —CN group, or a —NO2 group; Rv and Rw are each independently selected from the group consisting of hydrogen, phenyl, benzyl, and an optionally substituted C1-6alkyl, C2-6alkenyl or C2-6alkynyl group each of which may be optionally interrupted by an oxygen atom; and n is 0, 1, 2, 3 or 4;
Rf represents a hydrogen atom or a C1-4alkyl group; and
Rg represents a hydrogen atom or an optionally substituted alkyl, cycloalkyl, alkenyl, alkynyl, aryl, or heteroaryl group.

US Pat. No. 10,654,868

DIHYDROPYRAZOLE AZEPINE COMPOUND SERVING AS AKT INHIBITOR

HARBIN ZHENBAO PHARMACEUT...

1. A compound of formula (I) or a pharmaceutically acceptable salt thereof,
wherein,
R1 is H, halogen, CN, CH3, CH2CH3, CF3, cyclopropyl, phenyl or pyridyl;
X is C or N;
Y is S, O, N or N(CH3);
Z is C(R21)(R22), C(?O), O or S;
W is C(R61)(R62) or C(?O);
is a five-membered heteroaryl;each of R21, R22, R61 and R62 is independently H, halogen, hydroxyl, amino or methoxy;
m is 0, 1 or 2;
R3 is phenyl or pyridyl, which is optionally substituted by 1, 2 or 3 R;
each of R4 and R5 is independently H or CH3;
R is F, Cl, CN or CF3.

US Pat. No. 10,654,867

HETEROARYL ESTROGEN RECEPTOR MODULATORS AND USES THEREOF

Genentech, Inc., South S...

1. A compound having the structure:
or a pharmaceutically acceptable salt thereof.

US Pat. No. 10,654,865

ENANTIOSELECTIVE SYNTHESES OF HETEROYOHIMBINE NATURAL PRODUCT INTERMEDIATES

NORTHWESTERN UNIVERSITY, ...

1. A method of preparing a cis-bicyclic dihydropyran compound, said method comprising:providing a hydroxy ester compound of a formula

dehydration and reprotection of said hydroxy ester compound to provide an alkene compound of a formula
andhydroboration of said alkene compound to promote formation of a lactone compound of a formula
andacylation of said lactone compound and subsequent treatment with an acid catalyst to provide a cis-bicyclic dihydropyran compound of a formula

US Pat. No. 10,654,864

MODIFIED CYTOTOXINS AND THEIR THERAPEUTIC USE

The Regents of the Univer...

1. A pharmaceutical composition comprising:a first compound, which is a compound of formula (I)
A1-X1X—2-A2  (I)wherein:A2 is a cytotoxic drug moiety, which has a molecular weight of no more than 1600 Da, wherein the cytotoxic drug moiety comprises an oxygen atom or an NH group through which it connects to —X2—X1-A1; and
—X2—X1-A1 is selected from the group consisting of: —C(?O)—(CH2)n1—C(?O)—OH; —C(?O)—(CH2)n1—C(?O)—OCH3; —C(?O)—(C1-6 alkylene)-C(?O)—O—(CH2)n2—C(?O)—OH; —C(?O)—(C1-6alkylene)-NH—C(?O)—(CH2)n1—C(?O)—OH; and —C(?O)—(C1-6 alkylene)-C(?O)—O—[(CH2)2—O-]n3(CH2)n2—C(?O)—OH; wherein n1 is an integer 12 to 24, n2 is an integer from 13 to 25, and n3 is an integer from 1 to 25; and
a protein, wherein the protein is human serum albumin or a protein whose sequence is at least 80% equivalent to that of human serum albumin.

US Pat. No. 10,654,861

FUSED PENTACYCLIC IMIDAZOLE DERIVATIVES AS MODULATORS OF TNF ACTIVITY

UCB Biopharma SRL, Bruss...

1. A compound of formula (I) or an N-oxide thereof, or a pharmaceutically acceptable salt thereof:whereinA represents N or C—R6;
B represents N or C—R7;
D represents N or C—R8;
Z represents methylene;
E represents a fused heteroaromatic ring system selected from the groups of formula (Ea), (Eb) and (Ec):
wherein the asterisks (*) represent the site of attachment of E to the remainder of the molecule;R1 represents hydrogen, halogen, cyano, trifluoromethyl, trifluoromethoxy, —ORa, —SRa, —SORa, —SO2Ra, —NRbRc, —NRcCORd, —NRcCO2Rd, —NHCONRbRc, —NRbSO2Re, —CORd, —CO2Rd, —CONRbRc, —SO2NRbRc, or —S(O)(N—Rb)Re; or R1 represents C1-6 alkyl, C3-7 cycloalkyl, C4-7 cycloalkenyl, aryl, aryl(C1-6)alkyl, C3-7 heterocycloalkyl, C3-7 heterocycloalkenyl, heteroaryl, heteroaryl(C1-6)alkyl, (C3-7)heterocycloalkyl(C1-6)alkyl-aryl-, (C3-7)heterocycloalkenyl-aryl-, (C3-7)cycloalkyl-heteroaryl-, (C3-7)cycloalkyl-(C1-6)alkyl-heteroaryl-, (C4-7)cycloalkenyl-heteroaryl-, (C4-9)bicycloalkyl-heteroaryl-, (C3-7)heterocycloalkyl-heteroaryl-, (C3-7)heterocycloalkyl(C1-6)alkyl-heteroaryl-, (C3-7)heterocycloalkenyl-heteroaryl-, (C4-9)heterobicycloalkyl-heteroaryl- or (C4-9)spiroheterocycloalkyl-heteroaryl-, any of which groups may be optionally substituted by one, two or three substituents independently selected from halogen, halo(C1-6)alkyl, cyano, cyano(C1-6)alkyl, nitro(C1-6)alkyl, C1-6 alkyl, phosphate(C1-6)alkyl, (C1-6)alkylphosphate(C1-6)alkyl, phosphate(C1-6)alkoxy(C1-6)alkyl, sulphate(C1-6)alkyl, difluoromethyl, trifluoromethyl, trifluoroethyl, C2-6 alkenyl, hydroxy, hydroxy(C1-6)alkyl, C1-6 6 alkoxy, (C1-6)alkoxy(C1-6)-alkyl, trifluoroethoxy, carboxy(C3-7)cycloalkyloxy, C1-6 alkylthio, C1-6 alkylsulphonyl,(C1-6)alkylsulphonyl(C1-6)alkyl, oxo, amino, amino(C1-6)alkyl, C1-6 alkylamino, di(C1-6)-alkylamino, di(C1-6)alkylamino(C1-6)alkyl, (C1-6)alkoxy(C1-6)alkylamino, N—[(C1-6)alkyl]-N-[hydroxy(C1-6)alkyl]amino, (C2-6)alkylcarbonylamino(C1-6)alkyl, (C2-6)alkoxycarbonyl-amino(C1-6)alkyl, C1-6 alkylsulphinylamino, C1-6 alkylsulphonylamino, N—[(C1-6)alkyl]-N—[(C1-6)alkylsulphonyl]amino, bis[(C1-6)alkylsulphonyl]amino, (C1-6)alkylsulphonylamino-(C1-6)alkyl, N—[(C1-6)alkyl]-N-[carboxy(C1-6)alkyl]amino, carboxy(C3-7)cycloalkylamino, carboxy(C3-7)cycloalkyl(C1-6)alkylamino, imino, formyl, C2-6 alkylcarbonyl, (C2-6)alkyl-carbonyloxy(C1-6)alkyl, carboxy, carboxy(C1-6)alkyl, C2-6 alkoxycarbonyl, C2-6 alkoxy-carbonyl(C1-6)alkyl, morpholinyl(C1-6)alkoxycarbonyl, C2-6 alkoxycarbonylmethylidenyl, aminocarbonyl, aminosulphonyl, (C1-6)alkylsulphoximinyl and [(C1-6)alkyl][N—(C1-6)-alkyl]sulphoximinyl;R2 represents hydrogen, halogen, cyano, nitro, hydroxy, trifluoromethyl, trifluoromethoxy or —ORa; or R2 represents C1-6 alkyl or heteroaryl, either of which groups may be optionally substituted by one, two or three substituents independently selected from hydroxy(C1-6)alkyl and C2-6 alkoxycarbonyl;
R3 and R4 independently represent hydrogen, halogen or trifluoromethyl; or C1-6 alkyl;
R5 represents hydrogen, halogen, hydroxy, cyano, trifluoromethyl, difluoromethoxy, trifluoromethoxy, —ORa or C1-6 alkylsulphonyl; or R5 represents C1-6 alkyl;
R6, R7 and R8 independently represent hydrogen, halogen, trifluoromethyl, C1-6 alkyl or C1-6 alkoxy;
R12 represents hydrogen or C1-6 alkyl;
Ra represents C1-6 alkyl, C3-7 cycloalkyl, aryl, aryl(C1-6)alkyl, C3-7 heterocycloalkyl, heteroaryl or heteroaryl(C1-6)alkyl, any of which groups may be optionally substituted by one or more substituents selected from C1-6 alkoxy and oxo;
Rb represents hydrogen or trifluoromethyl; or C1-6 alkyl, C3-7 cycloalkyl, C3-7 cycloalkyl(C1-6)alkyl, aryl, aryl(C1-6)alkyl, C3-7 heterocycloalkyl, C3-7 heterocycloalkyl(C1-6)alkyl, heteroaryl or heteroaryl(C1-6)alkyl, any of which groups may be optionally substituted by one or more substituents selected from C1-6 alkoxy, C1-6 alkylthio, C1-6 alkylsulphinyl, C1-6 alkylsulphonyl, hydroxy, cyano, C2-6 alkoxycarbonyl, 6)alkylamino and C2-6 alkoxycarbonylamino;
Rc represents hydrogen or trifluoromethyl; or C1-6 alkyl, C3-7 cycloalkyl, C3-7 cycloalkyl(C1-6)alkyl, aryl, aryl(C1-6)alkyl, C3-7 heterocycloalkyl, C3-7 heterocycloalkyl(C1-6)alkyl, heteroaryl or heteroaryl(C1-6)alkyl, any of which groups may be optionally substituted by one or more substituents selected from C2-6 alkylcarbonyl and C2-6 alkoxycarbonyl; or
Rb and Rc, when taken together with the nitrogen atom to which they are both attached, represent a heterocyclic moiety selected from azetidin-1-yl, pyrrolidin-1-yl, oxazolidin-3-yl, isoxazolidin-2-yl, thiazolidin-3-yl, isothiazolidin-2-yl, piperidin-1-yl, morpholin-4-yl, thiomorpholin-4-yl, piperazin-1-yl, homopiperidin-1-yl, homomorpholin-4-yl, homopiperazin-1-yl, (imino)(oxo)thiazinan-4-yl, (oxo)thiazinan-4-yl and (dioxo)-thiazinan-4-yl, any of which groups may be optionally substituted by one or more substituents selected from C1-6 alkyl, C1-6 alkylsulphonyl, hydroxy, hydroxy(C1-6)alkyl, amino(C1-6)alkyl, cyano, oxo, C2-6 alkylcarbonyl, carboxy, C2-6 alkoxycarbonyl, amino, C2-6 alkylcarbonyl-amino, C2-6 alkylcarbonylamino(C1-6)alkyl, C2-6 alkoxycarbonylamino, C1-6 alkyl-sulphonylamino and aminocarbonyl;
Rd represents hydrogen; or Rd represents C1-6 alkyl, C3-7 cycloalkyl, aryl, C3-7 heterocycloalkyl or heteroaryl, any of which groups may be optionally substituted by one or more substituents selected from halogen, C1-6 alkyl, C1-6 alkoxy, oxo, C2-6 alkylcarbonyloxy and di(C1-6)alkylamino;
Re represents C1-6 alkyl, aryl or heteroaryl, any of which groups may be optionally substituted by C1-6 alkyl; and
Rf and Rg independently represent hydrogen or C1-6 alkyl.

US Pat. No. 10,654,860

TRICYCLIC RHO KINASE INHIBITORS

Bristol-Myers Squibb Comp...

1. A compound according to formula (I):
or a stereoisomer, tautomer, pharmaceutically acceptable salt thereof, wherein
X is independently selected from —CR3R4—, —O—, and NR5a;
Y is independently selected from —CR2 and N;
Z is independently selected from —NR5C(O)NR5(CR6R7)q—R8, —NR5C(O)(CR6R7)q—R8, —C(O)NR5(CR6R7)q—R8,

--- is an optional bond;
L is independently selected from —(CR6R7)q—, —NR5a(CR6R7)q—, and —O(CR6R7)q—;
R1 is independently selected from H, F, Cl, Br, CN, NRaRa, —OC1-4 alkyl substituted with 0-3 Re, C1-4 alkyl substituted with 0-3 Re, and —(CH2)rORb;
R2 is independently selected from H, F, Cl, Br, CN, NRaRa, —OC1-4 alkyl substituted with 0-3 Re, C1-4 alkyl substituted with 0-3 Re, —(CH2)rORb;
R3 and R4 are independently selected from H and C1-4 alkyl substituted with 0-3 Re;
R5 is independently selected from H and C1-4 alkyl;
R5a is independently selected from H and C1-4 alkyl;
R6 and R7 are independently selected from H, C1-4alkyl substituted with 0-4 Re, —(CH2)rORb, —(CH2)rS(O)pRc, —(CH2)rC(?O)Rb, —(CH2)rNRaRa, —(CH2)rC(?O)(CH2)rNRaRa, —(CH2)rNRaC(?O)Rb, —(CH2)rNRaC(?O)ORb, —(CH2)rOC(?O)NRaRa, —(CH2)rNRaC(?O)NRaRa, —(CH2)rC(?O)ORb, —(CH2)rS(O)pNRaRa, —(CH2)rNRaS(O)pNRaRa, —(CH2)rNRaS(O)pRc, (CH2)r—C3-6 carbocyclyl substituted with 0-3 Re, and —(CH2)r-heterocyclyl substituted with 0-3 Re;
is independently selected from carbocyclyl and heterocyclyl;R8 is selected from C3-10carbocyclyl and heterocyclyl, each substituted with 1-5 R9;
R9 is independently selected from H, F, Cl, Br, C1-4alkyl substituted with 0-5 Re, C2-4alkenyl substituted with 0-5 Re, C2-4alkynyl substituted with 0-5 Re, ?O, nitro, —(CHRd)rS(O)pRc, —(CHRd)rS(O)pNRaRa, —(CHRd)rNRaS(O)pRc, —(CHRd)rORb, —(CHRd)rCN, —(CHRd)rNRaRa, —(CHRd)rNRaC(?O)Rb, —(CHRd)rNRaC(?O)NRaRa, —(CHRd)rC(?O)ORb, —(CHRd)rC(?O)Rb, —(CHRd)r OC(?O)Rb, —(CHRd)rC(?O)NRaRa, —(CHRd)r-cycloalkyl, —(CHRd)r-heterocyclyl, —(CHRd)r-aryl, and —(CHRd)r-heteroaryl, wherein said alkyl, cycloalkyl, heterocyclyl, aryl, or heteroaryl is substituted with 0-4 Re;
alternatively, two adjacent R9 groups are combined to form a carbocyclic or heterocyclic ring comprising carbon atoms and 1-3 hetero atoms selected from N, O, and S(O)p, wherein the carbocyclic and heterocyclic rings are substituted with 0-4 Re;
R10 is independently selected from H, ?O, C1-4alkyl substituted with 0-4 Re, —(CH2)rORb, C(?O)Rb, and —C(?O)ORb;
Ra, at each occurrence, is independently selected from H, C1-6 alkyl substituted with 0-5 Re, C2-6alkenyl substituted with 0-5 Re, C2-6alkynyl substituted with 0-5 Re, —(CH2)r—C3-10carbocyclyl substituted with 0-5 Re, and —(CH2)r-heterocyclyl substituted with 0-5 Re; or Ra and Ra together with the nitrogen atom to which they are both attached form a heterocyclic ring substituted with 0-5 Re;
Rb, at each occurrence, is independently selected from H, C1-6 alkyl substituted with 0-5 Re, C2-6 alkenyl substituted with 0-5 Re, C2-6 alkynyl substituted with 0-5 Re, —(CH2)r—C3-10carbocyclyl substituted with 0-5 Re, and —(CH2)r-heterocyclyl substituted with 0-5 Re;
Rc, at each occurrence, is independently selected from C1-6 alkyl substituted with 0-5 Re, C2-6alkenyl substituted with 0-5 Re, C2-6alkynyl substituted with 0-5 Re, C3-6carbocyclyl, and heterocyclyl;
Rd, at each occurrence, is independently selected from H and C1-4alkyl substituted with 0-5 Re;
Re, at each occurrence, is independently selected from C1-6 alkyl (optionally substituted with F, Cl, and Br, OH), C2-6 alkenyl, C2-6 alkynyl, —(CH2)r—C3-10 carbocyclyl, —(CH2)r-heterocyclyl, F, Cl, Br, CN, NO2, ?O, CO2H, CO2C1-6 alkyl, —(CH2)rOC1-5 alkyl, —(CH2)rOH, —(CH2)rNRfRf, —(CH2)rNRfRfC(?O) C1-4alkyl, —C(?O)NRfRf, —C(?O)Rf, S(O)pNRfRf, —NRfRfS(O)pC1-4alkyl, and S(O)pC1-4alkyl;
Rf, at each occurrence, is independently selected from H, F, Cl, Br, C1-5alkyl, C3-6 cycloalkyl; or Rf and Rf together with the nitrogen atom to which they are both attached form a heterocyclic ring;
p, at each occurrence, is independently selected from zero, 1, and 2;
q, at each occurrence, is independently selected from zero, 1, 2, and 3; and
r, at each occurrence, is independently selected from zero, 1, 2, 3, and 4.

US Pat. No. 10,654,858

TRICYCLIC COMPOUNDS HAVING CYTOSTATIC AND/OR CYTOTOXIC ACTIVITY AND METHODS OF USE THEREOF

Duquesne University Of Th...

1. A method of inhibiting receptor tyrosine kinase(s), dihydrofolate reductase, thymidylate synthase and/or dihydroorotate dehydrogenase activity in an animal or human in need thereof, comprising administering to said animal or human a therapeutically effective amount in unit dosage form of a compound of formula II:
wherein both B and C rings may be completely or partially saturated or unsaturated with respect to bond 4b-8a, 5-6 and 7-8; the C ring is a carbon atom containing ring that may have one of the carbon atoms at either the Q5, Q6, Q7, or Q8 position replaced with a[n] N or substituted N depending on the saturation level of the C ring, and the substitution may be all of R1, R2 and R3;
X and/or Y=NH, O, S, CH2; P=(a) NR4, except that when P=NH and X is NH then R1 is not a phenyl moiety or a phenyl moiety having a halogen substitution, (b) O, except that when P=O and X is NH then R1 is not a phenyl moiety or a phenyl moiety having a halogen substitution, (c) S, except that when P=S and X is NH then R1 is not a phenyl moiety or a phenyl moiety having a halogen substitution, or (d) CR4R5 when the C ring has an N or a substituted N depending on the saturation level of the C ring and the substitution may be all of R1, R2, and R3; wherein R4 and R5=lower alkyl, alkene, alkyne, and all of R1 and R2;
R1 is H, alkyl, a cycloalkyl having 6 or less carbons, alkene, alkyne, aryl, heteroaryl, substituted aryl, substituted heteroaryl, alkylaryl, alkylheteroaryl, substituted alkylaryl or alkylheteroaryl and R2 is H, alkyl, a cycloalkyl having 6 or less carbons, alkene, alkyne, aryl, heteroaryl, substituted aryl, substituted heteroaryl, alkylaryl, alkylheteroaryl, substituted alkylaryl or alkylheteroaryl;
Z=S, O, NR6, S—CH2, CH2—S, O—CHR6, CHR6—O, NR6—CH2, CH2—NR6, CHR6—NR7 or CR6R7, wherein R6 and/or R7=H or a lower alkyl, alkene or alkyne having 6 or less C atoms;
wherein Z may be attached to the C ring at positions Q5, Q6, Q7 or Q8 and may be attached to more than one of said positions Q5, Q6, Q7, or Q8 on the ring wherein Z may be the same or different;
wherein Z may be zero and R3 may be directly attached to the C-ring at positions Q5, Q6, Q7, and/or Q8;
R3=H, alkyl, cycloalkyl, aryl, heteroaryl, substituted aryl, substituted heteroaryl, alkylaryl, alkylheteroaryl and substituted saturated or unsaturated alkylheteroaryl and alkylheterocyclic, alkylaryl, p-, m-, o-benzoyl-L-glutamate or 2,5-, 2,4-thienoyl-L-glutamate when the benzene and thiophene ring may or may not have additional substitutions including F, mono-, bi- and tricyclic aryl, heteroaryl or combinations thereof, ring substitutions including biphenyl, bipyridyl or a phenyl-pyridyl or a fused moiety including a quinoline or naphthyl including substituted systems including a 2-chloro,4-biphenyl and tricyclic and substituted tricyclic systems.

US Pat. No. 10,654,855

PROTEIN KINASE B INHIBITORS

AstraZeneca AB, Sodertal...

1. A method of treating breast cancer, comprising: administering to a person in need thereof a therapeutically effective amount of a compound of Formula (I), or a pharmaceutically acceptable salt thereof:
wherein:
Y represents N;
Z1-Z2 represents a group selected from C(R6)?CH; where
R6 represents hydrogen, fluoro, chloro, bromo, cyano, methyl, ethyl, difluoromethyl, trifluoromethyl or cyclopropyl;
n is 0, 1 or 2;
R1 represents C1-4alkyl, C2-4alkenyl, C2-4alkynyl, C1-4alkoxy, C1-4alkoxyC1-4alkyl, fluoroC1-4alkyl, aminoC1-4alkyl, hydroxyC1-4alkyl, cyano, cyanoC1-4alkyl, C3-6cycloalkyl, —(CH2)pNHCOCH3, —(CH2)pNHSO2CH3, —(CH2)pNHCONH2, —(CH2)pNHCONR2R3, —(CH2)pNR2R3, —(CH2)pSO2NH2, —(CH2)pSO2NR2R3, —(CH2)pCONH2, —(CH2)pCONR2R3 or —(CH2)p—R7; where
p is 0, 1, 2 or 3;
R2 represents hydrogen or C1-3alkyl;
R3 represents C1-3alkyl; and
R7 represents phenyl;
R7 represents a 5 or 6 membered monocyclic heteroaryl ring which comprises 1, 2 or 3 heteroatoms selected from O, N or S; or
R7 represents a monocyclic 4, 5, or 6 membered heterocyclic ring which comprises 1, 2 or 3 heteroatoms selected from O, N or S;
wherein R7 is optionally substituted by 1 or 2 substituents selected from C1-4alkyl, trifluoromethyl, C1-4alkoxy, fluoro, chloro, bromo, and cyano;
R4 represents hydrogen, fluoro, chloro, bromo, cyano or trifluoromethyl; and
R5 represents hydrogen, fluoro, chloro or bromo.

US Pat. No. 10,654,850

PYRIDAZINONES AND METHODS OF USE THEREOF

Goldfinch Bio, Inc., Cam...

1. A compound represented by:or a pharmaceutically acceptable salt thereof.

US Pat. No. 10,654,848

NEUTROPHIL INFLAMMATION INHIBITOR AND USES THEREOF

Chang Gung University of ...

1. A compound of formula (I), a salt, or a solvate thereof:
wherein,
X is N or O;
R1 is alkyl or nil, in which R1 is nil when X is O, and R1 is alkyl when X is N;
R2, R3, R4, and R5 are independently H, hydroxyl, sulfhydryl, halogen, alkyl, haloalkyl, —OR6, —SR6, —(C?O)R6, or —COOH; and
R6 is alkyl or haloalykl.

US Pat. No. 10,654,846

AUTOTAXIN INHIBITORY COMPOUNDS

Cancer Research Technolog...

1. A compound which is:N—[(S)-1-(4-chloro-phenyl)-ethyl]-3-[3-(4-trifluoromethoxy-benzyl)-3H-imidazo[4,5-b]pyridin-2-yl]-propionamide,

or a pharmaceutically acceptable salt or solvate thereof.

US Pat. No. 10,654,845

2-(HET)ARYL-SUBSTITUTED FUSED BICYCLIC HETEROCYCLE DERIVATIVES AS PESTICIDES

BAYER CROPSCIENCE AKTIENG...

1. A compound of formula (I)whereinA1 represents nitrogen,
A2 represents N—R5,
A4 represents C—H,
R1 represents methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl or tert-butyl,
R2a represents hydrogen,
R2b represents a group selected from
—C(?O)—R8 (Q1), where R8 represents methoxy or ethoxy,
—C(?O)—NR11R12 (Q3), where R11 represents hydrogen or methyl and R12 represents hydrogen, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, tert-butyl or cyclopropyl,
—C(?S)—NR11R12 (Q4), where R11 represents hydrogen or methyl and R12 represents methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, tert-butyl or cyclopropyl,
—S(O)m—R13 (Q5), where m represents 0, 1 or 2 and R13 represents methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, tert-butyl, phenyl or benzyl,
—S?O(?NH)—R13 (Q6), where R13 represents methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl or tert-butyl,
—S(?N—CN)—R13 (Q8), where R13 represents methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl or tert-butyl,
—S(O)2—NR11R12 (Q9), where R11 represents hydrogen, methyl, ethyl, n-propyl, isopropyl or cyclopropyl and R12 represents hydrogen, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, tert-butyl or cyclopropyl,
—NR11R12 (Q10), where R11 represents hydrogen, methyl, ethyl, n-propyl, isopropyl or cyclopropyl and R12 represents hydrogen, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, tert-butyl or cyclopropyl,
—NR11—NR11R12 (Q11), where R11 represents hydrogen, methyl, ethyl, n-propyl, isopropyl, cyclopropyl or COmethyl (acetyl) and R12 represents hydrogen, methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, tert-butyl, cyclopropyl or COmethyl (acetyl),
—NR11—C(?O)—R8 (Q12), where R11 represents hydrogen or methyl and R8 represents methyl, ethyl, n-propyl, isopropyl (where R8 represents methyl, ethyl, n-propyl, or isopropyl only if R11 does not represent hydrogen), trifluoromethyl, CHF2, CF2CF3, CF2CHF2, CH2OCH3, CH2SCH3, CH2OC2H5, CH2SOCH3, CH2SO2CH3, CH(CH3)CH2SCH3, CH(CH3)CH2SOCH3, CH(CH3)CH2SO2CH3, C2H4OC2H5, C2H4S C2H5, C2H4OC2H5, C2H4SOC2H5, C2H4SO2C2H5, CH(CH3)CH2SC2H5, CH(CH3)CH2SOC2H5, CH(CH3)CH2SO2C2H5, cyclopropyl, cyclopropylmethyl (—CH2-cyclopropyl), phenyl, benzyl,

NR11—C(?S)—R8 (Q13), where R8 represents methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, tert-butyl or cyclopropyl and R11 represents hydrogen, methyl, ethyl, n-propyl, isopropyl or cyclopropyl,
—NR11—S(O)2—R13 (Q14), where R11 represents hydrogen, methyl, ethyl, n-propyl, isopropyl, methylsulphonyl or cyclopropyl and R13 represents methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, tert-butyl, cyclopropyl or trifluoromethyl, and
—O—R13 (Q17), where R13 represents trifluoromethyl-1H-pyrazol-5-yl

with the proviso that if R2b represents Q5, Q6, Q8 or Q9, then n represents 2,
R3 represents fluoromethyl, difluoromethyl, trifluoromethyl, fluoroethyl, difluoroethyl, trifluoroethyl, tetrafluoroethyl or pentafluoroethyl,
R5 represents methyl, ethyl or isopropyl, and
n is 0, 1 or 2.

US Pat. No. 10,654,844

DUAL MECHANISM INHIBITORS FOR THE TREATMENT OF DISEASE

Aerie Pharmaceuticals, In...

1. A pharmaceutically acceptable salt of

US Pat. No. 10,654,841

PROCESSES WITH TERMINAL TRANSFERASE, AMINOXY NUCLEOSIDE TRIPHOSPHATES, AND NUCLEOBASE ANALOGS

1. A process for synthesizing an oligonucleotide that has a 3?-ONH2 moiety instead of a 3?-OH moiety, said process comprising contacting an oligodeoxyribonucleotide in an aqueous buffered solution with terminal deoxynucleotide transferase and a nucleoside triphosphate having the structure:
or one of its ionized forms, wherein B is a heterocycle selected from the group consisting of

wherein Su indicates the point of attachment of the heterocycle to the sugar, and
wherein said solution contains less than 1 micromolar hydroxylamine.

US Pat. No. 10,654,836

PYRIMIDINE DERIVATIVE, METHOD FOR PREPARING SAME AND USE THEREOF IN MEDICINE

Zhejiang Hisun Pharmaceut...

1. A compound represented by formula (I) or a stereoisomer, tautomer thereof or a pharmaceutically acceptable salt thereof:
wherein:
each of R1 is independently selected from alkyl, halogen, alkoxy, cycloalkyl, heterocyclyl, aryl, heteroaryl, —NR7R8, —C(O)NR7R8, —C(O)R9, —C(O)OR9 or —NR7C(O)R8, wherein the alkyl, alkoxy, cycloalkyl, heterocyclyl, aryl or heteroaryl is optionally further substituted by one or more substituents selected from the group consisting of hydroxyl, halogen, nitro, cyano, alkyl, alkoxy, cycloalkyl, heterocyclyl, aryl, heteroaryl, —NR7R8, —C(O)NR7R8, —C(O)R9, —C(O)OR9 and —NR7C(O)R8;
R2 is selected from:
—NR4C(O)CR5?CHR6 or —NR4C(O)C?CR5;
R3 is a spiroheterocyclyl, wherein the spiroheterocyclyl is optionally further substituted by one or more substituents selected from the group consisting of hydroxyl, halogen, nitro, cyano, alkyl, alkoxy, cycloalkyl, heterocyclyl, aryl, heteroaryl, haloalkoxy, —NR7R8, —C(O)NR7R8, —C(O)R9, —C(O)OR9 and —NR7C(O)R8;
each of R4 is independently selected from hydrogen or alkyl, wherein the alkyl is optionally further substituted by one or more substituents selected from the group consisting of hydroxy, halogen, nitro, cyano, alkyl, alkoxy, cycloalkyl, heterocyclyl, aryl, heteroaryl, haloalkoxy, —NR7R8, —C(O)NR7R8, —C(O)R9, —C(O)OR9 and —NR7C(O)R8;
R5 and R6 are each independently selected from hydrogen, alkyl or halogen, wherein the alkyl is optionally further substituted by one or more substituents selected from the group consisting of hydroxy, halogen, nitro, cyano, alkyl, alkoxy, cycloalkyl, heterocyclyl, aryl, heteroaryl, haloalkoxy, —NR7R8, —C(O)NR7R8, —C(O)R9, —C(O)OR9 and —NR7C(O)R8;
R7, R8 and R9 are each independently selected from hydrogen, alkyl, cycloalkyl, heterocyclyl, aryl or heteroaryl, wherein the alkyl, cycloalkyl, heterocyclyl, aryl or heteroaryl is optionally further substituted by one or more substituents selected from the group consisting of hydroxy, halogen, nitro, cyano, alkyl, alkoxy, cycloalkyl, heterocyclyl, aryl, heteroaryl, —NR10R11, —C(O)NR10R11, —C(O)R12, —C(O)OR12 and —NR10C(O)R11;
alternatively, R7 and R8 together with the N atom to which they are attached form a 4 to 8 membered heterocyclyl, wherein the 4 to 8 membered heterocyclic ring contains one or more N, O, S(O)n atoms, and the 4 to 8 membered heterocyclic ring is further substituted by one or more substituents selected from the group consisting of hydroxy, halogen, nitro, cyano, alkyl, alkoxy, cycloalkyl, heterocyclyl, aryl, heteroaryl, ?O, —NR10R11, —C(O)NR11R11, —C(O)R12, —C(O)OR12 and —NR10C(O)R11;
R10, R11 and R12 are each independently selected from hydrogen, alkyl, cycloalkyl, heterocyclyl, aryl or heteroaryl, wherein the alkyl, cycloalkyl, heterocyclyl, aryl or heteroaryl are optionally further substituted by one or more substituents selected from the group consisting of hydroxy, halogen, nitro, cyano, alkyl, alkoxy, cycloalkyl, heterocyclyl, aryl, heteroaryl, carboxylic acid or carboxylate;
m is 1, 2, 3 or 4; and
n is 0, 1, or 2.

US Pat. No. 10,654,834

NON-SYSTEMIC TGR5 AGONISTS

Venenum Biodesign, LLC, ...

1. A compound of formula (I)
or a pharmaceutically acceptable salt thereof, wherein:
each R1 is independently CN, C1-6alkyl, pyridyl, or C1-6alkoxy, wherein alkyl group is optionally further substituted with 1-4 halogen;
m is 0, 1, 2 or 3;
R2 is C1-6alkyl or H, wherein alkyl group is optionally further substituted with 1-4 halogen;
X is CH or N;
P is CH or N;
L1, L2 and L3 are each independently absent,

wherein N is optionally further substituted with C1-3alkyl;
n1, n2, n3 and n4 are each independently 0, 1, 2, 3, 4 or 5, and when L1 is absent, n2 is 0, when L2 is absent, n3 is 0, when L3 is absent, n4 is 0, with the proviso that when L1, L2 and L3 are all absent, n1 cannot be 0;
each R is independently H, OH, NH2, COOH, C1-6alkylCOOH, COOC1-6alkyl, C1-6 alkylOH or C1-6 alkylNHC(NH)NH2;
T is

CN, OH, NH2 or OCH3, wherein N is optionally further substituted with C1-3 alkyl;
R3 and R4 are each independently H, OH, halogen, N(CH3)2 or NH2; and
n is 0, 1 or 2.

US Pat. No. 10,654,833

ASK1 ISOINDOLIN-1-ONE INHIBITORS AND METHODS OF USE THEREOF

Hepatikos Therapeutics, L...

1. A compound, or a pharmaceutically acceptable salt thereof, of Formula I:
wherein:
Ring A is selected from the group consisting of aryl, heteroaryl, 5-6-membered heterocyclyl, and 4-6-membered carbocyclyl;
R1 is selected from the group consisting of —(C1-6 alkylene)pCO2R20, —O(C1-6 alkylene)pCO2R20, —(C1-6 alkylene)p(carbocyclylene)CO2R20, —O(C1-6 alkylene)p(carbocyclylene)CO2R20, unsubstituted —(C2-9 alkenyl), unsubstituted —(C2-9 alkynyl), unsubstituted —(C1-9 haloalkyl), —(C1-6 alkylene)carbocyclyl optionally substituted with 1-10 R4, —(C1-6 alkylene)pheterocyclyl optionally substituted with 1-10 R5, —(C1-6 alkylene)paryl optionally substituted with 1-5 R6, —(C1-6 alkylene)pheteroaryl optionally substituted with 1-5 R7, —(C1-6 alkylene)pOR8, —(C1-6 alkylene)pSR8, —(C1-6 alkylene)pS(?O)R9, —(C1-6 alkylene)pSO2R10 , —(C1-6 alkylene)pN(R11)SO2R12, —(C1-6 alkylene)pSO2N(R13)2, —(C1-6 alkylene)pN(R14)2, —(C1-6 alkylene)pN(R11)C(?O)N(R15)2, —(C1-6 alkylene)pNR11C(?O)OR16, —(C1-6 alkylene)pC(?O)N(R17)2, —(C1-6 alkylene)pN(R11)C(?O)R18, and —(C1-6 alkylene)pOC(?O)N(R19)2; wherein each —(C1-4 alkylene) is, independently, optionally substituted with one or more substituents as defined anywhere herein; wherein each (carbocyclylene) is, independently, optionally substituted with one or more substituents as defined anywhere herein; wherein each CO2R20 can be replaced with a carbocyclic acid bioisostere thereof;
R2 is selected from the group consisting of halide, Me, OMe, CN, —SO2R10, —N(R14)2, —(C1-4 alkylene)pOH; wherein —(C1-4 alkylene) of —(C1-4 alkylene)pOH is optionally substituted with one or more OH;
alternatively, an adjacent R1 and R2 are taken together with the atoms to which they are attached to form a ring which is selected from the group consisting of

R3 is selected from the group consisting of unsubstituted —(C1-9 alkyl), unsubstituted —(C2-9 alkenyl), unsubstituted —(C2-9 alkynyl), unsubstituted —(C1-9 haloalkyl), —(C1-4 alkylene)OR21, and —(C1-4 alkylene)pcarbocyclyl optionally substituted with one or more halides; wherein each —(C1-4 alkylene) is, independently, optionally substituted with one or more halides;
each R4 is selected from the group consisting of halide, unsubstituted —(C1-6 alkyl), unsubstituted —(C2-6 alkenyl), unsubstituted —(C2-6 alkynyl), unsubstituted —(C1-6 haloalkyl), —OH, —N(R23)2, —CN, and —OMe;
each R5 is selected from the group consisting of halide, unsubstituted —(C1-6 alkyl), unsubstituted —(C2-6 alkenyl), unsubstituted —(C2-6 alkynyl), unsubstituted —(C1-6 haloalkyl), —OH, —N(R23)2, —CN, and —OMe;
each R6 is selected from the group consisting of halide, unsubstituted —(C1-6 alkyl), unsubstituted —(C2-6 alkenyl), unsubstituted —(C2-6 alkynyl), unsubstituted —(C1-6 haloalkyl), —OH, —N(R23)2, —CN, and —OMe;
each R7 is selected from the group consisting of halide, unsubstituted —(C1-6 alkyl), unsubstituted —(C2-6 alkenyl), unsubstituted —(C2-6 alkynyl), unsubstituted —(C1-6 haloalkyl), —OH, —N(R23)2, —CN, and —OMe;
R8 is selected from the group consisting of H, unsubstituted —(C3-6 alkyl), unsubstituted —(C2-6 alkenyl), unsubstituted —(C2-6 alkynyl), unsubstituted —(C1-6 haloalkyl), —(C1-3 alkylene)pcarbocyclyl optionally substituted with one of more halides and/or unsubstituted —(C1-6 alkyl), —(C1-3 alkylene)pheterocyclyl optionally substituted with one of more halides and/or unsubstituted —(C1-6 alkyl), —(C1-3 alkylene)paryl optionally substituted with one of more halides and/or unsubstituted —(C1-6 alkyl), and —(C1-3 alkylene)pheteroaryl optionally substituted with one of more halides and/or unsubstituted —(C1-6 alkyl); wherein each —(C1-4 alkylene) is, independently, optionally substituted with one or more halides;
R9 is selected from the group consisting of unsubstituted —(C1-6 alkyl), unsubstituted —(C2-6 alkenyl), unsubstituted —(C2-6 alkynyl), unsubstituted —(C1-6 haloalkyl), —(C1-3 alkylene)pcarbocyclyl optionally substituted with one of more halides and/or unsubstituted —(C1-6 alkyl), —(C1-3 alkylene)pheterocyclyl optionally substituted with one of more halides and/or unsubstituted —(C1-6 alkyl), —(C1-3 alkylene)paryl optionally substituted with one of more halides and/or unsubstituted —(C1-6 alkyl), and —(C1-3 alkylene)pheteroaryl optionally substituted with one of more halides and/or unsubstituted —(C1-6 alkyl); wherein each —(C1-4 alkylene) is, independently, optionally substituted with one or more halides;
R10 is selected from the group consisting of unsubstituted —(C1-6 alkyl), unsubstituted —(C2-6 alkenyl), unsubstituted —(C2-6 alkynyl), unsubstituted —(C1-6 haloalkyl), —(C1-3 alkylene)pcarbocyclyl optionally substituted with one of more halides and/or unsubstituted —(C1-6 alkyl), —(C1-3 alkylene)pheterocyclyl optionally substituted with one of more halides and/or unsubstituted —(C1-6 alkyl), —(C1-3 alkylene)paryl optionally substituted with one of more halides and/or unsubstituted —(C1-6 alkyl), and —(C1-3 alkylene)pheteroaryl optionally substituted with one of more halides and/or unsubstituted —(C1-6 alkyl); wherein each —(C1-4 alkylene) is, independently, optionally substituted with one or more halides;
each R11 is selected from the group consisting of H, unsubstituted —(C1-6 alkyl), unsubstituted —(C2-6 alkenyl), unsubstituted —(C2-6 alkynyl), and unsubstituted —(C1-6 haloalkyl);
R12 is selected from the group consisting of unsubstituted —(C1-6 alkyl), unsubstituted —(C2-6 alkenyl), unsubstituted —(C2-6 alkynyl), unsubstituted —(C1-6 haloalkyl), —(C1-3 alkylene)pcarbocyclyl optionally substituted with one of more halides and/or unsubstituted —(C1-6 alkyl), —(C1-3 alkylene)pheterocyclyl optionally substituted with one of more halides and/or unsubstituted —(C1-6 alkyl), —(C1-3 alkylene)paryl optionally substituted with one of more halides and/or unsubstituted —(C1-6 alkyl), and —(C1-3 alkylene)pheteroaryl optionally substituted with one of more halides and/or unsubstituted —(C1-6 alkyl); wherein each —(C1-4 alkylene) is, independently, optionally substituted with one or more halides;
each R13 is selected from the group consisting of H, unsubstituted —(C1-6 alkyl), unsubstituted —(C2-6 alkenyl), unsubstituted —(C2-6 alkynyl), unsubstituted —(C1-6 haloalkyl), —(C1-3 alkylene)pcarbocyclyl optionally substituted with one of more halides and/or unsubstituted —(C1-6 alkyl), —(C1-3 alkylene)pheterocyclyl optionally substituted with one of more halides and/or unsubstituted —(C1-6 alkyl), —(C1-3 alkylene)paryl optionally substituted with one of more halides and/or unsubstituted —(C1-6 alkyl), and —(C1-3 alkylene)pheteroaryl optionally substituted with one of more halides and/or unsubstituted —(C1-6 alkyl); wherein each —(C1-4 alkylene) is, independently, optionally substituted with one or more halides;
each R14 is selected from the group consisting of H, unsubstituted —(C1-6 alkyl), unsubstituted —(C2-6 alkenyl), unsubstituted —(C2-6 alkynyl), unsubstituted —(C1-6 haloalkyl), —(C1-3 alkylene)pcarbocyclyl optionally substituted with one of more halides and/or unsubstituted —(C1-6 alkyl), —(C1-3 alkylene)pheterocyclyl optionally substituted with one of more halides and/or unsubstituted —(C1-6 alkyl), —(C1-3 alkylene)paryl optionally substituted with one of more halides and/or unsubstituted —(C1-6 alkyl), and —(C1-3 alkylene)pheteroaryl optionally substituted with one of more halides and/or unsubstituted —(C1-6 alkyl); wherein each —(C1-4 alkylene) is, independently, optionally substituted with one or more halides;
each R15 is selected from the group consisting of H, unsubstituted —(C1-6 alkyl), unsubstituted —(C2-6 alkenyl), unsubstituted —(C2-6 alkynyl), unsubstituted —(C1-6 haloalkyl), —(C1-3 alkylene)pcarbocyclyl optionally substituted with one of more halides and/or unsubstituted —(C1-6 alkyl), —(C1-3 alkylene)pheterocyclyl optionally substituted with one of more halides and/or unsubstituted —(C1-6 alkyl), —(C1-3 alkylene)paryl optionally substituted with one of more halides and/or unsubstituted —(C1-6 alkyl), and —(C1-3 alkylene)pheteroaryl optionally substituted with one of more halides and/or unsubstituted —(C1-6 alkyl); wherein each —(C1-4 alkylene) is, independently, optionally substituted with one or more halides;
R16 is selected from the group consisting of unsubstituted —(C1-6 alkyl), unsubstituted —(C2-6 alkenyl), unsubstituted —(C2-6 alkynyl), unsubstituted —(C1-6 haloalkyl), —(C1-3 alkylene)pcarbocyclyl optionally substituted with one of more halides and/or unsubstituted —(C1-6 alkyl), —(C1-3 alkylene)pheterocyclyl optionally substituted with one of more halides and/or unsubstituted —(C1-6 alkyl), —(C1-3 alkylene)paryl optionally substituted with one of more halides and/or unsubstituted —(C1-6 alkyl), and —(C1-3 alkylene)pheteroaryl optionally substituted with one of more halides and/or unsubstituted —(C1-6 alkyl); wherein each —(C1-4 alkylene) is, independently, optionally substituted with one or more halides;
each R17 is selected from the group consisting of H, unsubstituted —(C1-6 alkyl), unsubstituted —(C2-6 alkenyl), unsubstituted —(C2-6 alkynyl), unsubstituted —(C1-6 haloalkyl), —(C1-3 alkylene)pcarbocyclyl optionally substituted with one of more halides and/or unsubstituted —(C1-6 alkyl), —(C1-3 alkylene)pheterocyclyl optionally substituted with one of more halides and/or unsubstituted —(C1-6 alkyl), —(C1-3 alkylene)paryl optionally substituted with one of more halides and/or unsubstituted —(C1-6 alkyl), and —(C1-3 alkylene)pheteroaryl optionally substituted with one of more halides and/or unsubstituted —(C1-6 alkyl); wherein each —(C1-4 alkylene) is, independently, optionally substituted with one or more halides;
R18 is selected from the group consisting of unsubstituted —(C1-6 alkyl), unsubstituted —(C2-6 alkenyl), unsubstituted —(C2-6 alkynyl), unsubstituted —(C1-6 haloalkyl), —(C1-3 alkylene)pcarbocyclyl optionally substituted with one of more halides and/or unsubstituted —(C1-6 alkyl), —(C1-3 alkylene)pheterocyclyl optionally substituted with one of more halides and/or unsubstituted —(C1-6 alkyl), —(C1-3 alkylene)paryl optionally substituted with one of more halides and/or unsubstituted —(C1-6 alkyl), and —(C1-3 alkylene)pheteroaryl optionally substituted with one of more halides and/or unsubstituted —(C1-6 alkyl); wherein each —(C1-4 alkylene) is, independently, optionally substituted with one or more halides;
each R19 is selected from the group consisting of H, unsubstituted —(C1-6 alkyl), unsubstituted —(C2-6 alkenyl), unsubstituted —(C2-6 alkynyl), unsubstituted —(C1-6 haloalkyl), —(C1-3 alkylene)pcarbocyclyl optionally substituted with one of more halides and/or unsubstituted —(C1-6 alkyl), —(C1-3 alkylene)pheterocyclyl optionally substituted with one of more halides and/or unsubstituted —(C1-6 alkyl), —(C1-3 alkylene)paryl optionally substituted with one of more halides and/or unsubstituted —(C1-6 alkyl), and —(C1-3 alkylene)pheteroaryl optionally substituted with one of more halides and/or unsubstituted —(C1-6 alkyl); wherein each —(C1-4 alkylene) is, independently, optionally substituted with one or more halides;
R20 is selected from the group consisting of H, unsubstituted —(C1-6 alkyl), unsubstituted —(C2-6 alkenyl), unsubstituted —(C2-6 alkynyl), unsubstituted —(C1-6 haloalkyl), —(C1-3 alkylene)pcarbocyclyl optionally substituted with one of more halides and/or unsubstituted —(C1-6 alkyl), —(C1-3 alkylene)pheterocyclyl optionally substituted with one of more halides and/or unsubstituted —(C1-6 alkyl), —(C1-3 alkylene)paryl optionally substituted with one of more halides and/or unsubstituted —(C1-6 alkyl), and —(C1-3 alkylene)pheteroaryl optionally substituted with one of more halides and/or unsubstituted —(C1-6 alkyl); wherein each —(C1-4 alkylene) is, independently, optionally substituted with one or more halides;
R21 is selected from the group consisting of H, unsubstituted —(C1-5 alkyl), unsubstituted —(C2-5 alkenyl), unsubstituted —(C2-5 alkynyl), and unsubstituted —(C1-5 haloalkyl);
each n is independently 0 to 5; and
each p is independently 0 or 1.

US Pat. No. 10,654,828

INDOLE DERIVATIVES AND USES THEREOF

NOVARTIS AG, Basel (CH)

1. A compound of formula (I) or a pharmaceutically acceptable salt thereof:wherein:L is absent, O, S, NHCO or CONH;
X is CH or N;
R1 is H, C1-4alkyl, C1-4haloalkyl, or 3-6 membered cycloalkyl;
R2 is H, —OH, halo, —CN, nitro, C1-4alkoxy, C1-4alkyl, C1-4alkoxy-C1-4alkyl, C1-4haloalkyl, C1-4hydroxyalkyl, a 5-10 membered heterocyclyl optionally substituted with 1-3 C1-4alkyl groups, —(CH2)n-(6 or 10 membered aryl optionally substituted with 1-3 C1-4alkyl groups), or —(CH2)n-(5-10 membered heteroaryl optionally substituted with 1-3 C1-4alkyl groups);
R3 is H, halo, —OH, C1-4alkyl, C1-4alkoxy, C1-4haloalkyl or C1-4 haloalkoxy;
R4 is a substituted C2-4alkynyl, a substituted or unsubstituted 5-10 membered heterocyclyl, a substituted or unsubstituted 5-10 membered heteroaryl, a substituted or unsubstituted 5-10 membered fused heterocyclyl-aryl, a substituted or unsubstituted 5-10 membered fused heterocyclyl-heteroaryl, or a substituted or unsubstituted 6 or 10 membered aryl, wherein when R4 is substituted, R4 is substituted with 1-3 substituents independently selected from halo, —OH, oxo (?O), —CN, nitro, C1-4alkyl, —C1-4alkyl-(3-6 membered cycloalkyl), C1-4alkoxy, —SO2—C1-4alkyl, —SO2—C1-4hydroxyalkyl, —SO2—C1-4alkyl-NR5R6, —NHSO2—C1-4alkyl, C1-4hydroxyalkyl, —SO2NR5R6, —CO—C1-4hydroxyalkyl, —CONR5R6, —CO—C1-4alkyl-NR5R6, —CO—NH—C1-4alkyl-NR5R6,—NR5R6, —C1-4alkyl-NR5R6 and —CO—C1-4alkyl;
R5 and R6 are each, independently, selected from H, C1-4alkyl, C1-4hydroxyalkyl, —CO—C1-4alkyl and -(4-10 membered heterocyclyl)-C1-4alkyl; or R5 and R6, together with the nitrogen atom to which they are attached, form a 5-7 membered heterocyclyl optionally substituted with 1-3 C1-4alkyl groups; and
n is 0 or 1.

US Pat. No. 10,654,826

1,3,5-TRIAZINE DERIVATIVE AND METHOD OF USING SAME

Chia Tai Tianqing Pharmac...

7. A pharmaceutical composition, comprising the compound according to claim 1, or a pharmaceutically acceptable salt or hydrate thereof, and one or more pharmaceutically acceptable carriers or excipients.

US Pat. No. 10,654,825

PROCESSES FOR MAKING TRIAZOLO[4,5D] PYRAMIDINE DERIVATIVES AND INTERMEDIATES THEREOF

CORVUS PHARMACEUTICALS, I...

1. A method of isolating a precipitate of the formula (I):comprising the steps of:(a) reacting a compound of the formula:

with a compound of the formula:
in the presence of a base;wherein,
X1 and X2 are independently halo, and
wherein R is —(CRaRb)—O—R2;
Ra is H or alkyl;
Rb is H or alkyl; or Ra and Rb together with the atom to which they are attached form a 3 to 8 membered saturated or partially saturated hydrocarbon ring or form a 4 to 8 membered saturated or partially saturated heterocylic ring comprising a ring member selected from O, N(R3) and S;
R2 is H, alkyl, cycloalkyl or heterocycloalkyl, wherein said alkyl or cycloalkyl may optionally be substituted with halo, alkoxy or heterocycloalkyl;
R3 is H or alkyl;
wherein, heteroaryl is a 5 or 6 membered aromatic ring, comprising one or two ring members selected from N, N(R4), S and O;
alkyl (or the alkyl group of the alkoxy group) is a linear or branched saturated hydrocarbon containing up to 10 carbon atoms;
heterocycloalkyl is a C-linked or N-linked 3 to 10 membered non-aromatic, monocyclic ring, wherein said heterocycloalkyl ring comprises 1, 2 or 3 ring members independently selected from N, N(R4), S(O)q and O;
R4 is H or alkyl; and
q is 0, 1 or 2; and
(b) isolating the precipitate of formula (I).

US Pat. No. 10,654,824

2-AZABICYCLO[3.1.0]HEXAN-3-ONE DERIVATIVES AND METHODS OF USE

Genentech, Inc., South S...

18. A pharmaceutical composition comprising a compound of claim 1, or a stereoisomer, tautomer, solvate or prodrug thereof, or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, diluent or excipient.

US Pat. No. 10,654,818

FURANE DERIVATIVES AS INHIBITORS OF ATAD2

BAYER PHARMA AKTIENGESELL...

1. A compound of general formula I
in which
R1 represents a benzyl group wherein the ?-position is substituted by one methyl group of R configuration or two methyl groups, and the 4-position may be substituted by a methyl group, a halogen atom, a 4-trifluoromethyl group,
R2 represents a C1-6-alkyl group,
a C1-6-hydroxyalkyl group,
a —C1-3-alkylen-O—(C1-6-alkyl) group,
a —C1-6-aminoalkyl group,
a —C1-3-alkylen-N—(C1-6-alkyl)2 group,
a —C1-3-alkylen-NH—(C1-6-alkyl) group,
a —C1-3-alkylen-NH—(C1-4-alkyl)-OH group,
a —C1-3-alkylen-NH—(C3-7-cycloalkyl)-NH2 group,
a —C1-3-alkylen-NH—C1-4-alkylen-heterocycloalkyl group which is optionally substituted with C1-3-alkyl,
a —C1-3-alkylen-NH-heterocycloalkyl group which is optionally substituted independently from each occurrence one or more times with C1-4-alkyl, halogen, benzyl, C(O)R7,
a —C1-3-alkylen-NH—(C1-3-alkylen)-phenyl group,
a —C1-3-alkylen-NH—C(O)(C1-4-alkyl) group,
a —C1-3-alkylen-NH—C(O)—C1-4-alkylen-heterocycloalkyl group,
a —C1-3-alkylen-NH—C1-3-alkylen-C(O)-heterocycloalkyl group,
a —C1-3-alkylen-NH—C(O)-heterocycloalkyl group,
a —C1-3-alkylen-NH—S(O)2-(C1-4-alkyl) group,
a —C1-3-alkylen-(4-cyano-phenyl) group, a —C1-3-alkylen-C(O)—NH—(C1-6-alkyl) group,
a —C1-3-alkylen-C(O)—NH—(C1-4-alkyl)-OH group,
a —C1-3-alkylen-C(O)—NR8R9 group,
a —C1-3-alkylen-C(O)—R7 group,
a —C1-3-alkylen-C(O)-heterocycloalkyl group which is optionally substituted with C1-3-alkyl,
a —C1-3-alkylen-heterocycloalkyl group which is optionally one or more times substituted with C1-3-alkyl,
a C(O)R7 group,
a —C(O)—NR8R9 group,
a C(O)—NH—(C3-7-cycloalkyl)-NH2 group,
a —C(O)—NH-heterocycloalkyl group which is optionally substituted with C1-3-alkyl, a heteroaryl group,
R3 a —C1-3-alkylen-phenyl group which is independently from each occurrence optionally substituted 1 to 3 times with a substituent selected from the group cyano, halogen, C1-3-alkyl, C1-3-alkoxy, amino, C(O)R7, C(O)NR8R9,
a —C1-4-alkylen-heteroaryl group, or
R2 and R3 together with the carbon atom to which they are attached form the following 6-membered ring whereby the star * indicates the carbon atoms which are attached to said carbon atom of absolute configuration R

R4 represents a hydrogen atom, a methyl group, a chlorine atom,
R5 represents a hydrogen atom or a halogen atom,
R6 represents a hydrogen atom, a halogen atom, a hydroxy group, a C1-3 alkoxy group, or a cyano group,
R7 represents a —O—C1-4-alkyl group,
R8, R9, represents, independently for each occurrence, a hydrogen atom or a C1-4-alkyl group, or the salts thereof, the solvates thereof or the solvates of the salts thereof,
with the proviso that the following compounds
2-Chlor-N-[(2R)-1-(4-cyanphenyl)-4-(methylamino)-4-oxobutan-2-yl]-5-[5-({[(1R)-1-(4-methylphenyl)ethyl]amino}methyl)-2-furyl]benzamide
N-[(2R)-1-(4-cyanophenyl)-4-(methylamino)-4-oxobutan-2-yl]-2-fluoro-5-[5-({[(1R)-1-(4-methylphenyl)ethyl]amino}methyl)-2-furyl]benzamide
2-chloro-N-[(2R)-1-(4-fluorophenyl)-4-(methylamino)-4-oxobutan-2-yl]-5-[5-({[(1R)-1-(4-methylphenyl)ethyl]amino}methyl)-2-furyl]benzamide
N-[(2R)-1-(4-cyanophenyl)-4-(methylamino)-4-oxobutan-2-yl]-2-methyl-5-[5-({[(1R)-1-(4-methylphenyl)ethyl]amino}methyl)-2-furyl]benzamide
2-chloro-N-[(2R)-1-(4-cyanophenyl)-4-(methylamino)-4-oxobutan-2-yl]-5-[5-({[(1R)-1-(4-fluorophenyl)ethyl]amino}methyl)-2-furyl]benzamide
are excluded.

US Pat. No. 10,654,817

ORGANO-1-OXA-4-AZONIUM CYCLOHEXANE COMPOUNDS

1. A morpholinium compound comprising a 1-oxa-4-azonium cyclohexane salt having a structure of:
wherein R1-R8 are independently selected from H or an alkyl group having the formula CnH2n+1, R9 is C2H5, where n is in the range from 1 to 4, X is halide or hydroxide, the total number of C atoms in the molecule is in the range of 11 to 24, and R10 is an alkyl group having the formula CmH2m, where m is in the range from 3 to 8 and is connected to the 4 and 4? N atoms at positions x and y of the alkyl chain where x and y are independently selected from 1 to m; with the proviso that: when R1-R8 are H, R9 is C2H5, R10 is C6H12, x is 1, and y is 6, X is hydroxide.

US Pat. No. 10,654,815

UREA COMPOUND AND PREPARATION METHOD AND APPLICATION THEREOF

SHENZHEN CHIPSCREEN BIOSC...

1. A compound of Formula I,or a prodrug, a stereoisomer, and a pharmaceutically acceptable salt or a hydrate thereof; wherein,R1 is one or more substituents independently selected from the group consisting of H, C1-C4 alkyl, CN, halogen, NH2, COOH, C1-C4 alkylamino, C1-C4 alkyloxy, C1-C4 haloalkyl and Ar1, which substituents are the same or different;
wherein,
Ar1 is selected from the group consisting of
wherein,R4 is one or more substituents independently selected from the group consisting of H, C1-C4 alkyl, CN, halogen, NH2, COOH, C1-C4 alkylamino, C1-C4 alkyloxy and C1-C4 haloalkyl, which substituents are the same or different;
i is an integer from 1 to 5;
Z is selected from the group consisting of C, NH, O, C(O), S, S(O) and S(O)2;
R2 is selected from the group consisting of H, C1-C4 alkyl, —CH2—(CH2)k—CN and —(CH2)k—Ar2;
wherein,
k is an integer from 0 to 6;
Ar2 is selected from

wherein,
R5 is one or more substituents independently selected from the group consisting of H, C1-C4 alkyl, CN, halogen, NH2, COOH, C1-C4 alkylamino, C1-C4 alkyloxy and Ci-C4 haloalkyl, which substituents are the same or different;
v is an integer from 1 to 5;
R3 is one or more substituents independently selected from the group consisting of H, C1-C4 alkyl, CN, halogen, C1-C4 alkyloxy and C1-C4 haloalkyl, which substituents are the same or different;
X is selected from C and N;
Y is selected from NH, O, S, S(O) and S(O)2;
A is selected from the group consisting of
or A is a side chain of an amino acid selected from the group consisting of Gly, Ala, Ser, Lys, Arg, Thr, Asn, Gln, Phe or Gluor A is a side chain of an amino acid selected from the group consisting of Gly, Ala, Ser, Lys, Arg, Thr, Asn, Gln, Phe and Glu, which is substituted with R6
wherein,
R6 is one or more substituents independently selected from the group consisting of H, C1-C4 alkyl, C1-C4 alkylcarbonyl, alkenylcarbonyl and C1-C4 alkylamino C1-C4 alkyl C1-C4 alkenylcarbonyl, which substituents are the same or different;
het is selected from saturated or aromatic heterocycles, morpholine, N-methylpiperazine, tetrahydropyrrole, pyridine, thiophene, thiazole, triazole and tetrazole;
w is an integer from 0 to 2;
m is an integer from 1 to 5;
n is an integer from 1 to 3;
p is independently an integer from 0 to 2; and
q is an integer from 0 to 2.